@article{20963, abstract = {In all domains of life, tRNAs mediate the transfer of genetic information from mRNAs to proteins. As their depletion suppresses translation and, consequently, viral replication, tRNAs represent long-standing and increasingly recognized targets of innate immunity1,2,3,4,5. Here we report Cas12a3 effector nucleases from type V CRISPR–Cas adaptive immune systems in bacteria that preferentially cleave tRNAs after recognition of target RNA. Cas12a3 orthologues belong to one of two previously unreported nuclease clades that exhibit RNA-mediated cleavage of non-target RNA, and are distinct from all other known type V systems. Through cell-based and biochemical assays and direct RNA sequencing, we demonstrate that recognition of a complementary target RNA by the CRISPR RNA triggers Cas12a3 to cleave the conserved 5′-CCA-3′ tail of diverse tRNAs to drive growth arrest and anti-phage defence. Cryogenic electron microscopy structures further revealed a distinct tRNA-loading domain that positions the tRNA tail in the RuvC active site of the nuclease. By designing synthetic reporters that mimic the tRNA acceptor stem and tail, we expanded the capacity of current CRISPR-based diagnostics for multiplexed RNA detection. Overall, these findings reveal widespread tRNA inactivation as a previously unrecognized CRISPR-based immune strategy that broadens the application space of the existing CRISPR toolbox.}, author = {Dmytrenko, Oleg and Yuan, Biao and Crosby, Kadin T. and Krebel, Max and Chen, Xiye and Nowak, Jakub S. and Chramiec-Głąbik, Andrzej and Filani, Bamidele and Gribling-Burrer, Anne-Sophie and van der Toorn, Wiep and von Kleist, Max and Achmedov, Tatjana and Smyth, Redmond P. and Glatt, Sebastian and Bravo, Jack Peter Kelly and Heinz, Dirk W. and Jackson, Ryan N. and Beisel, Chase L.}, issn = {1476-4687}, journal = {Nature}, publisher = {Springer Nature}, title = {{RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity}}, doi = {10.1038/s41586-025-09852-9}, year = {2026}, } @article{20971, abstract = {Mountain glaciers are among the natural systems most vulnerable to climate change. However, their interactions with the atmosphere are complex and not fully understood. These interactions can trigger rapid adjustments and climate feedbacks that either amplify or attenuate atmospheric signals, influencing both glacier response and large-scale atmospheric circulation. Observing this functional coupling in nature is challenging because the key processes occur over a wide range of spatial and temporal scales. However, recent advances in observational techniques and modeling have provided new insights into these interactions. In this review, we summarize the current state of knowledge on glacier-atmosphere interactions in high-mountain regions at different scales, and highlight recent advances in observational and numerical modeling. We also highlight important knowledge gaps and outline future research directions to improve the prediction of glacier change in a warming world.}, author = {Sauter, T. and Brock, B. W. and Collier, E. and Goger, B. and Groos, A. R. and Haualand, K. F. and Mott, R. and Nicholson, L. and Prinz, R. and Shaw, Thomas and Stiperski, I. and Georgi, A. and Haugeneder, M. and Mandal, A. and Reynolds, D. and Saigger, M. and Sicart, J. E. and Voordendag, A.}, issn = {1944-9208}, journal = {Reviews of Geophysics}, number = {1}, title = {{Glacier-atmosphere interactions and feedbacks in high-mountain regions - A review}}, doi = {10.1029/2024RG000869}, volume = {64}, year = {2026}, } @article{20972, abstract = {Small amounts of stress are thought to have beneficial effects. A new study reports a mechanism by which the psychedelic drug, psilocybin, causes acute release of stress hormones, despite its known long-term anti-anxiety effects.}, author = {Kücükdereli, Hakan and Douglass, Amelia May Barnett}, issn = {1879-0445}, journal = {Current Biology}, number = {1}, pages = {R27--R29}, publisher = {Elsevier}, title = {{Neuroscience: What doesn’t kill you makes you stronger}}, doi = {10.1016/j.cub.2025.11.056}, volume = {36}, year = {2026}, } @article{20974, abstract = {Thus far, Lyman-α damping wings towards quasars have been used to probe the global ionization state of the foreground intergalactic medium (IGM). A new parametrization has demonstrated that the damping wing signature also carries local information about the distribution of neutral hydrogen (H I) in front of the quasar before it started shining. Leveraging a recently introduced Bayesian JAX-based Hamiltonian Monte Carlo inference framework, we derive constraints on the Lorentzian-weighted H I column density NDW H I , the quasar’s distance rpatch to the first neutral patch, and its lifetime tQ based on James Webb Space Telescope (JWST) Near Infrared Spectrograph (NIRSpec) spectra of the two z ∼ 7.5 quasars J1007+2115 and J1342+0928. After folding in model-dependent topology information, we find that J1007+2115 (and J1342+0928) is most likely to reside in a (xH1)= 0.32+0.22 −0.20 (0.58+0.23 −0.23) neutral IGM while shining for a remarkably short lifetime of log10 tQ/yr = 4.14+0.74 −0.18 (an intermediate lifetime of 5.64+0.25 −0.43) along a sightline with log10 NDW H I /cm−2 = 19.70+0.35 −0.86 (20.24+0.25 −0.22) and rpatch = 28.9+54.0 −14.4 cMpc (10.9+5.6−5.9 cMpc). In light of the potential presence of local absorbers in the foreground of J1342+0928 as has been recently suggested, we also demonstrate how the Lorentzian-weighted column density NDW H I provides a natural means for quantifying their contribution to the observed damping wing signal.}, author = {Kist, Timo and Hennawi, Joseph F. and Davies, Frederick B. and Bañados, Eduardo and Bosman, Sarah E.I. and Cai, Zheng and Eilers, Anna Christina and Fan, Xiaohui and Haiman, Zoltán and Jun, Hyunsung D. and Liu, Yichen and Yang, Jinyi and Wang, Feige}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {3}, publisher = {Oxford University Press}, title = {{First constraints on the local ionization topology in front of two quasars at z ∼ 7.5}}, doi = {10.1093/mnras/staf2219}, volume = {545}, year = {2026}, } @article{20975, abstract = {Galaxy clusters are the most massive, gravitationally bound structures in the Universe. They emerged through hierarchical structure formation of large-scale dark matter and baryon overdensities. Early galaxy ‘proto-clusters’ are believed to have substantially contributed to the cosmic star-formation rate density and served as ‘hotspots’ for the reionization of the intergalactic medium. Our understanding of the formation of these structures at the earliest cosmic epochs is, however, limited to sparse observations of their galaxy members or is based on phenomenological models and cosmological simulations. Here we report the detection of a large and coherent structure of neutral atomic hydrogen gas (H i) extending from a galaxy proto-cluster at redshift z = 5.4, one billion years after the Big Bang. The presence of this H i gas is revealed by strong damped Lyman-α absorption features observed in several background-galaxy spectra. Although the sight lines overall probe a large range in H i column densities, NHI = 1020 cm−2 to 1023.5 cm−2, they are similar across nearby sight lines, demonstrating that they probe the same dense neutral gas. This observation of a dense large-scale overdensity of cold neutral gas challenges current cosmological simulations and has strong implications for the reionization topology of the Universe.}, author = {Heintz, Kasper E. and Bennett, Jake S. and Oesch, Pascal A. and Sneppen, Albert and Rennehan, Douglas and Pollock, Clara L. and Witstok, Joris and Smit, Renske and Vejlgaard, Simone and Terp, Chamilla and Koca, Umran S. and Brammer, Gabriel B. and Finlator, Kristian and Hayes, Matthew J. and Sijacki, Debora and Naidu, Rohan P. and Matthee, Jorryt J and Valentino, Francesco and Tanvir, Nial R. and Jakobsson, Páll and Laursen, Peter and Watson, Darach J. and Davé, Romeel and Keating, Laura C. and Covelo-Paz, Alba}, issn = {2397-3366}, journal = {Nature Astronomy}, publisher = {Springer Nature}, title = {{A dense web of neutral gas in a galaxy proto-cluster post-reionization}}, doi = {10.1038/s41550-025-02745-x}, year = {2026}, } @article{20980, abstract = {Morse decompositions partition the flows in a vector field into equivalent structures. Given such a decomposition, one can define a further summary of its flow structure by what is called a connection matrix. These matrices, a generalization of Morse boundary operators from classical Morse theory, capture the connections made by the flows among the critical structures—such as attractors, repellers, and orbits—in a vector field. Recently, in the context of combinatorial dynamics, an efficient persistence-like algorithm to compute connection matrices has been proposed in Dey, Lipiński, Mrozek, and Slechta [SIAM J. Appl. Dyn. Syst., 23 (2024), pp. 81–97]. We show that, actually, the classical persistence algorithm with exhaustive reduction retrieves connection matrices, both simplifying the algorithm of Dey et al. and bringing the theory of persistence closer to combinatorial dynamical systems. We supplement this main result with an observation: the concept of persistence as defined for scalar fields naturally adapts to Morse decompositions whose Morse sets are filtered with a Lyapunov function. We conclude by presenting preliminary experimental results.}, author = {Dey, Tamal K. and Haas, Andrew and Lipiński, Michał}, issn = {1536-0040}, journal = {SIAM Journal on Applied Dynamical Systems}, number = {1}, pages = {108--130}, publisher = {Society for Industrial & Applied Mathematics}, title = {{Computing a connection matrix and persistence efficiently from a morse decomposition}}, doi = {10.1137/25m1739406}, volume = {25}, year = {2026}, } @article{20986, abstract = {During complex vocal interactions, different features of acoustic stimuli are integrated to produce appropriate vocal responses,1 such as copying sounds during vocal matching behavior in some animals.2,3,4,5,6,7,8,9,10,11,12 However, little is known about the interplay and possible trade-offs between the different temporal and spectral acoustic features during these vocal exchanges.2,13,14 Nightingales can flexibly match the pitch of their tonal “whistle songs” in real time during counter-singing duels.15,16 Here, we show that the syllable duration of whistle playbacks could alter the song responses of wild nightingales, causing their whistle duration distribution to shift toward the presented stimulus duration. When exposed to whistle playbacks featuring unnatural combinations of pitch and duration, nightingales demonstrate a flexible trade-off between pitch matching and temporal imitation, yet they are constrained by their vocal repertoire. They selectively adapted their vocal responses to approximate these novel stimuli, aligning them with their natural whistle repertoire. We developed a computational model of nightingale whistle-matching behavior that revealed a hierarchical organization of acoustic feature production. During whistle matching, the feature integration process is constrained by the duration of syllables, and pitch matching follows within this temporal framework, forcing a trade-off between the two features. Our findings reveal a complex interplay between the spectral and temporal domains that shapes song-matching behavior.}, author = {Calderon Garcia, Juan Sebastian and Costalunga, Giacomo and Vogels, Tim P and Vallentin, Daniela}, issn = {1879-0445}, journal = {Current Biology}, publisher = {Elsevier}, title = {{Interplay between syllable duration and pitch during whistle matching in wild nightingales}}, doi = {10.1016/j.cub.2025.12.025}, year = {2026}, } @article{21001, abstract = {Copper chalcogenides offer high charge mobility and low lattice thermal conductivity but suffer from structural instability due to dynamic Cu+ migration. Here, we report a colloidal hot-injection synthesis of ternary cesium copper selenide (CsCu5Se3) nanocrystals (NCs), achieving precise control over phase, size, and morphology through tailored precursor-ligand modulation. This strategy enabled systematic exploration of stable and metastable Cs–Cu–Se phases and mechanistic investigation of nucleation and growth, providing insight into phase modulation and dimensional control at the nanoscale. CsCu5Se3 NCs exhibit low lattice thermal conductivity (∼0.5 Wm–1K–1) and an experimental zT of 0.27 at 718 K. Complementary first-principles calculations, consistent with experimental electronic and optical responses, predict a zT of 1.05 at 1000 K. These findings elucidate the formation dynamics of CsCu5Se3 and establish ABZ (A = alkali, B = metal, Z = chalcogen) NCs as tunable platforms for advanced functional applications.}, author = {Patil, Niraj Nitish and Wu, Ruiqi and Fiedler, Christine and Kapuria, Nilotpal and Nan, Bingfei and Navita, Navita and Cabot, Andreu and Ibáñez, Maria and Ryan, Kevin M. and Ganose, Alex M. and Singh, Shalini}, issn = {2380-8195}, journal = {ACS Energy Letters}, number = {1}, pages = {481--488}, publisher = {American Chemical Society}, title = {{Layered alkali-copper selenides: Deciphering thermoelectric properties and reaction pathways for nanostructuring β-CsCu5Se3}}, doi = {10.1021/acsenergylett.5c02909}, volume = {11}, year = {2026}, } @article{21002, abstract = {The Davenport–Heilbronn method is a version of the circle method that was developed for studying Diophantine inequalities in the paper (Davenport and Heilbronn, J. Lond. Math. Soc. (1) 21 (1946), 185–193). We discuss the main ideas in the paper, together with an account of the development of the subject in the intervening 80 years.}, author = {Browning, Timothy D}, issn = {1469-7750}, journal = {Journal of the London Mathematical Society}, number = {1}, publisher = {Wiley}, title = {{The Davenport–Heilbronn method: 80 years on}}, doi = {10.1112/jlms.70371}, volume = {113}, year = {2026}, } @article{21008, abstract = {C(sp2)–heteroatom couplings operating via NiI/NiIII catalysis have emerged as an alternative to canonical Pd0/PdII systems that require complex ligand architectures. Despite intensive research efforts during the past decade, catalytic methods employing this approach are still mostly confined to activated starting materials and require high catalyst loadings due to the low catalytic activity of NiI and undesired catalyst deactivation events. This article highlights recent advances in the field toward solving these long-standing challenges. We survey strategies that streamline the generation of catalytically competent NiI species from bench-stable NiII precatalysts, and discuss mechanistic studies that shed light on deactivation pathways and the rate-determining oxidative addition of aryl halides. In the final section, we highlight recently developed synthetic methodologies, which provide evidence that limitations can indeed be addressed by working at elevated temperatures, employing alternative electrophiles, harnessing the benefits of additives, or fine-tuning the metal’s reactivity through the ligand field.}, author = {Bena, Aleksander and Pieber, Bartholomäus}, issn = {2155-5435}, journal = {ACS Catalysis}, number = {2}, pages = {866--881}, publisher = {American Chemical Society}, title = {{Advances in NiI/NiIII-catalyzed C(sp2)–heteroatom cross-couplings}}, doi = {10.1021/acscatal.5c07964}, volume = {16}, year = {2026}, } @article{21012, abstract = {In certifiable machine learning, AI systems produce not only results but also verifiable certificates that the results can be trusted.}, author = {Barrett, Clark and Henzinger, Thomas A and Seshia, Sanjit A.}, issn = {1557-7317}, journal = {Communications of the ACM}, number = {1}, pages = {66--75}, publisher = {Association for Computing Machinery}, title = {{Certificates in AI: Learn but verify}}, doi = {10.1145/3737447}, volume = {69}, year = {2026}, } @article{21013, abstract = {We have addressed convective self‐aggregation (CSA) in steady and oscillating sea surface temperature (SST) and solar radiation (SOLIN) cloud‐resolving model simulations in a non‐rotating radiative‐convective equilibrium (RCE) framework. Our experiment designs are motivated by land‐ocean heterogeneity of atmospheric convection. The steady and oscillating forcings are idealizations of ocean and land conditions, respectively, based on their differences in heat capacities. In both kinds of simulations, the diurnal mean SST and SOLIN are the same, and both SST and SOLIN are only varied in time (i.e., they are spatially homogeneous at any given time). We find that diurnally oscillating forcing accelerates CSA. Stronger long‐wave cooling in dry regions at night and during the warm SST phase (late afternoon) both allow the long‐wave feedback, known to favor aggregation, to intensify compared to steady forcing simulations. In addition to the long‐wave, reduced short‐wave warming in dry regions (during the day) further enhances radiative cooling there compared to moist regions. Overall, the radiative cooling is enhanced in dry regions compared to neighboring moist convective regions. A dry subsidence is driven by this net radiative (short‐wave plus long‐wave) cooling, consistent with earlier work on CSA. Stronger radiative cooling allows stronger subsidence which allows low‐level circulation to more efficiently transport moisture and energy up‐gradient, driving convection to aggregate faster. We also note a sensitivity of our experimental setup to initial conditions, more so at warmer SST. This stochastic behavior might be critical in reconciling the differences of opinion regarding the response of convection aggregation to oscillating SST forcing.}, author = {GOSWAMI, BIDYUT B and Lu, Ziyin and Muller, Caroline J}, issn = {1942-2466}, journal = {Journal of Advances in Modeling Earth Systems}, number = {1}, publisher = {Wiley}, title = {{Convective self‐aggregation in diurnally oscillating sea surface temperature and solar forcing experiments}}, doi = {10.1029/2024ms004576}, volume = {18}, year = {2026}, } @article{21018, abstract = {In this paper, we review recent results on stability and instability in logarithmic Sobolev inequalities, with a particular emphasis on strong norms. We consider several versions of these inequalities on the Euclidean space, for the Lebesgue and the Gaussian measures, and discuss their differences in terms of moments and stability. We give new and direct proofs, as well as examples and discuss the stability of a logarithmic uncertainty principle. Although we do not cover all aspects of the topic, we hope to contribute to establishing the state of the art.}, author = {Brigati, Giovanni and Dolbeault, Jean and Simonov, Nikita}, issn = {2730-9657}, journal = {La Matematica}, publisher = {Springer Nature}, title = {{Logarithmic Sobolev Inequalities: A review on stability and instability results}}, doi = {10.1007/s44007-025-00180-y}, volume = {5}, year = {2026}, } @article{21035, abstract = {According to the scientific consensus, tropical convection must decrease with global warming. This decrease is manifested by a decrease of the mass transported in the upward branch of the atmospheric overturning circulation – the convective mass flux – and a connected decrease of high clouds in the tropics, with implications for climate sensitivity. By using kilometer-scale simulations in radiative-convective equilibrium and a convective tracking algorithm, we show that no such decrease occurs in storms when taken individually and that the mass transport per storm increases instead. Storms can achieve this result by aggregating more surface of the convective cores – the inner part of the storm doing the vertical transport – so that the decrease of tropical convection is actually explained by a decrease in the total number of storms. There is little variation of the mean pressure velocity in the cores of the storms, a robust finding of this study. This remarkable invariance of the mean pressure velocity points to an emerging property of convection that should receive more attention in future studies.}, author = {Bolot, Maximilien and Roca, Rémy and Fiolleau, Thomas and Muller, Caroline J}, issn = {2397-3722}, journal = {npj Climate and Atmospheric Science}, publisher = {Springer Nature}, title = {{No decrease of tropical convection in individual deep convective systems with global warming}}, doi = {10.1038/s41612-025-01285-5}, volume = {9}, year = {2026}, } @article{21036, abstract = {Forests under livestock grazing sustain important ecosystem services but face potential trade-offs between production and ecological integrity. While the effects of grazing on individual forest attributes are well documented, their integrated consequences remain poorly understood, particularly in temperate forest ecosystems. We evaluated the combined influence of livestock grazing intensity and canopy cover on individual attributes and ecosystem multifunctionality in native Nothofagus forests of Tierra del Fuego, Argentina. Across eight ranches spanning two agroecological regions (Ecotone and Mountain Range), we quantified forest regeneration, understorey richness and biomass, and soil properties, integrating them into a multifunctionality index. Using generalized linear mixed models, we found strong context-dependence: in the Mountain Range, higher grazing intensity reduced seedling and sapling density, organic matter content, coarse woody debris, and overall multifunctionality. In the Ecotone, these effects of livestock use intensity were attenuated, and canopy cover diminished sapling density and multifunctionality, but moderate cover enhanced understorey. Our results extend multifunctionality research from grazed grasslands to grazed temperate forests and show that ecological responses and trade-offs vary across landscape units. We conclude that the Mountain Range is more vulnerable to grazing, requiring stricter management, whereas the Ecotone retains greater capacity to sustain multifunctionality under controlled livestock use intensity. These findings underscore the importance of region-specific silvopastoral strategies that reconcile food production with forest conservation in southern Patagonia and comparable temperate forest landscapes worldwide.}, author = {Rodríguez, Paula and Cruz Alonso, Verónica and Romano, Silvina and Bustamante, Gimena and Soler Schaller, Rosina Matilde}, issn = {0167-8809}, journal = {Agriculture, Ecosystems and Environment}, publisher = {Elsevier}, title = {{Context-dependent effects of livestock grazing on forest attributes and ecosystem multifunctionality in Nothofagus forests}}, doi = {10.1016/j.agee.2026.110219}, volume = {400}, year = {2026}, } @article{21037, abstract = {The oxygen reduction reaction (ORR) remains a critical bottleneck in fuel cells and metal-air batteries due to the lack of highly efficient electrocatalysts. Here, we report a simple strategy for synthesizing a palladium-based heterostructured electrocatalyst supported on a carbon nitride matrix (PdH-Pd@CN), which exhibits remarkable ORR activity with a half-wave potential of 0.91 V and excellent durability in 0.1 M KOH. Within the heterostructure, hydrogen intercalation expands the Pd lattice, while interstitial hydrogen doping facilitates charge transfer from Pd to H owing to their electronegativity difference. These synergistic effects modulate the electronic structure, thereby enhancing both activity and stability. When employed in Zn-air batteries, PdH-Pd@CN delivers a maximum power density of 176 mW cm− (Liu et al., 2025) and capacity of 805 mAh g− (Sun et al., 2021) Zn. These findings demonstrate the strong potential of PdH-Pd@CN as an efficient ORR electrocatalyst for next-generation metal-air batteries and related energy technologies.}, author = {Shi, Changwei and Horta, Sharona and Ibáñez, Maria and Kallio, Tanja and Martínez-Alanis, Paulina R. and Wang, Xiang and Cabot, Andreu}, issn = {0009-2509}, journal = {Chemical Engineering Science}, publisher = {Elsevier}, title = {{Hydrogen induced palladium-based heterojunction electrocatalysts to enhance the oxygen reduction reaction performance}}, doi = {10.1016/j.ces.2026.123348}, volume = {324}, year = {2026}, } @article{21038, abstract = {Little Red Dots (LRDs) are compact sources at z > 5 discovered through James Webb Space Telescope spectroscopy. Their spectra exhibit broad Balmer emission lines (>~1000 km s^−1), alongside absorption features and a pronounced Balmer break – evidence for a dense, neutral hydrogen medium, in which the n = 2 state is significantly populated. When interpreted as arising from active galactic nucleus broad-line regions, inferred black hole masses from local scaling relations exceed expectations given their stellar masses, challenging models of early black hole–galaxy co-evolution. However, radiative transfer effects in dense media may also impact the formation of hydrogen emission lines. We model three scattering processes shaping hydrogen line profiles: resonance scattering by hydrogen in the n = 2 state, Raman scattering of ultraviolet (UV) radiation by ground-state hydrogen, and Thomson scattering by free electrons. Using 3D Monte Carlo radiative transfer simulations, we examine their imprint on line shapes and ratios. Resonance scattering produces strong deviations from Case B flux ratios, clear differences between Hα and Hβ, and encodes gas kinematics in line profiles but cannot broaden Hβ due to conversion to Paα. While Raman scattering can yield broad wings, scattering of the UV continuum is disfavoured given the absence of strong full width at half-maximum variations across transitions. Raman scattering of higher Lyman-series emission can produce Hα/Hβ wing width ratios of >~1.28, agreeing with observations. Thomson scattering can reproduce the observed >~ 1000 km s^−1 wings under plausible conditions – e.g. Te ∼ 10^4 K and Ne ∼ 10^24 cm^−2 – and lead to black hole mass overestimates by factors 10. Our results provide a framework for interpreting hydrogen lines in LRDs and similar systems.}, author = {Chang, Seok Jun and Gronke, Max and Matthee, Jorryt J and Mason, Charlotte}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {4}, publisher = {Oxford University Press}, title = {{Impact of resonance, Raman, and Thomson scattering on hydrogen line formation in Little Red Dots}}, doi = {10.1093/mnras/staf2131}, volume = {545}, year = {2026}, } @article{21039, abstract = {Cellular plasticity, the ability of a differentiated cell to adopt another phenotypic identity, is restricted under basal conditions, but can be elicited upon damage. However, the molecular mechanism enabling such plasticity remains largely unexplored. Here, we report damage-induced cellular plasticity of secretory enteroendocrine cells (EEs) in the adult Drosophila midgut. Ionizing radiation induces EE fate conversion and activates stress-responsive programs in EE lineages, accompanied by the induction of the stress-inducible transcription factor Xrp1 and the cytokine gene upd3. Xrp1 and upd3 are both necessary for radiation-induced EE plasticity. Under basal conditions, EE-specific Xrp1 overexpression triggers ectopic expression of progenitor-specific genes, which is necessary for Xrp1 to drive EE plasticity. Our work identifies Xrp1 as a crucial regulator that coordinates damage-induced signaling and transcriptional reprogramming, enabling the reactivation of cellular plasticity in differentiated cells.}, author = {Qian, Qingyin and Nagai, Hiroki and Sanaki, Yuya and Hayashi, Makoto and Kimura, Kenichi and Nakajima, Yu Ichiro and Niwa, Ryusuke}, issn = {1477-9129}, journal = {Development}, number = {2}, publisher = {The Company of Biologists}, title = {{Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut}}, doi = {10.1242/dev.205225}, volume = {153}, year = {2026}, } @article{21040, abstract = {Formation during the first cycles of Li-rich layered oxide (LRLO) cathode materials consolidates the interphase and leads to structural changes that are decisive for long-term cyclability. However, the nature and effect of the changes are material-dependent and unknown for the important class of Co-free, Ni-poor LRLOs. Here, we analyze the processes during the tailored formation procedure of a typical class member, Li1.28Ni0.15Mn0.57O2, and demonstrate that it remarkably changes lattice composition and structure as a prerequisite for stable cycling. We combine electrochemistry, operando mass spectrometry, X-ray diffraction, and X-ray absorption spectroscopy with density functional theory simulations. Activation most prominently compresses the layer spacing along the c-axis and increases reversible structural breathing. The large capacity of ∼250 mAh g–1 originates from the Ni2+/Ni4+ and O2–/O– redox couples. Electron exchange during O-redox is smeared over the entire anionic sublattice rather than localized on specific oxygen atomic sites. This redox mechanism is reversible without detrimental oxygen evolution, avoiding continued degradation common in conventional LRLOs. Sequential Ni- and O-redox during activation irreversibly distorts the coordination of the redox-inactive Mn4+ centers. This structural evolution of the MnO6 octahedra appears to enable the superior electrochemical performance of this LRLO phase. These findings define an activation pathway for the important class of Co-free, Ni-poor LRLOs, offering potential guidance for the rational design of high-performance, more sustainable cathode materials.}, author = {Busato, Matteo and Tuccillo, Mariarosaria and Celeste, Arcangelo and Tofoni, Alessandro and Silvestri, Laura and D’Angelo, Paola and Freunberger, Stefan Alexander and Brutti, Sergio}, issn = {2574-0962}, journal = {ACS Applied Energy Materials}, number = {1}, pages = {686--697}, publisher = {American Chemical Society}, title = {{Structural rearrangements of a Cobalt-free Lithium-rich layered oxide cathode during formation}}, doi = {10.1021/acsaem.5c03511}, volume = {9}, year = {2026}, } @article{21041, abstract = {It is common for programmers to assemble their programs from a combination of trusted and untrusted components. In this context, a trusted program component is said to be robustly safe if it behaves safely when linked against arbitrary untrusted code. Prior work has shown how various encapsulation mechanisms (in both high- and low-level languages) can be used to protect code so that it is robustly safe, but none of the existing work has explored how robust safety can be achieved in a patently unsafe language like C. In this paper, we show how to bring robust safety to a simple yet representative C-like language we call Rec. Although Rec (like C) is inherently ”dangerous” and thus not robustly safe, we can ”save” Rec programs via compilation to Cap, a CHERI-like capability machine. To formalize the benefits of such a hardening compiler, we develop Reckon, a separation logic for verifying robust safety of Rec programs. Reckon is not sound under Rec’s unsafe, C-like semantics, but it is sound when Rec programs are hardened via compilation and linked against untrusted code running on Cap. As a crucial step in proving soundness of Reckon, we introduce a novel technique of semantic back-translation, which we formalize by building on the DimSum framework for multi-language semantics. All our results are mechanized in the Rocq prover.}, author = {Mück, Niklas and Georges, Aïna Linn and Dreyer, Derek and Garg, Deepak and Sammler, Michael Joachim}, issn = {2475-1421}, journal = {Proceedings of the ACM on Programming Languages}, pages = {1153--1182}, publisher = {Association for Computing Machinery}, title = {{Endangered by the language but saved by the compiler: Robust safety via semantic back-translation}}, doi = {10.1145/3776682}, volume = {10}, year = {2026}, }