@article{23027,
  abstract     = {Kinetic constraints are generally expected to slow down dynamics in many-body systems, obstructing or even
completely suppressing transport of conserved charges. Here, we show how gauge theories can defy this wisdom
by yielding constrained models with faster-than-diffusive dynamics. We first show how, upon integrating out
the gauge fields, one-dimensional U(1) lattice gauge theories are exactly mapped onto XX models with nonlocal
constraints. This class of kinetically constrained models interpolates between free theories and highly constrained
local fermionic models. We find that energy transport is superdiffusive over a broad parameter regime. Even
more drastically, spin transport exhibits ballistic behavior, albeit with anomalous finite-volume properties as a
consequence of gauge invariance. Our findings are relevant to current efforts in quantum simulations of gauge theory dynamics and anomalous hydrodynamics in closed quantum many-body systems.},
  author       = {Bhakuni, Devendra Singh and Verdel, Roberto and Desaules, Jean-Yves Marc and Serbyn, Maksym and Ljubotina, Marko and Dalmonte, Marcello},
  issn         = {2469-9969},
  journal      = {Physical Review B},
  number       = {14},
  publisher    = {American Physical Society},
  title        = {{Anomalously fast transport in nonintegrable lattice gauge theories}},
  doi          = {10.1103/3371-88bl},
  volume       = {114},
  year         = {2026},
}

@unpublished{23011,
  abstract     = {Alternative splicing represents a major source of potential evolutionary novelty in protein sequence. Despite this, relatively few studies have investigated the functional impacts of human-specific alternative splicing. Here, we analyze RNA-sequencing data from nine iPSC-derived cell types and identify dozens of human transcriptomic conserved deletions (htCONDELs): evolutionary divergence in splicing that leads to the partial or full removal of conserved protein-coding sequence from the human transcriptome. We investigated one example in detail: an htCONDEL in the gene
HMMR
                  , which encodes a centrosomal protein that binds microtubules and regulates mitosis. We found that this htCONDEL, which produces a human-specific isoform lacking a conserved microtubule-binding domain, enables cells to flexibly divide with a broader range of mitotic spindle orientations
      in vitro
                  . Introducing the human
                  HMMR
                  isoform into mice similarly alters the orientation of cell division in the developing neocortex and increases the production of outer radial glia-like cells, the expansion of which played an essential role in increasing human brain size. Combined with previous work implicating the same
                 HMMR
                  isoform in carcinoma progression, our results suggest that evolution of
HMMR
                  splicing in humans increased plasticity in cell division, potentially leading to tradeoffs between advantageous effects on brain development and deleterious effects on cancer risk later in life.},
  author       = {Starr, Alexander L. and Villalba Requena, Ana and Rever, Jenna and Chen, Yuwei and Pauler, Florian and Magtanong, Leslie and Maxwell, Christopher A. and Hippenmeyer, Simon and Fraser, Hunter B.},
  booktitle    = {bioRxiv},
  title        = {{A human transcriptomic deletion links cortical expansion and cancer}},
  doi          = {10.64898/2026.09.16.752114},
  year         = {2026},
}

@article{23003,
  abstract     = {The peripheral neural pathways that relay oral and post-ingestive chemo- and mechanosensory signals to the brain during food consumption are increasingly well understood. Far less is known about how these and other body signals are integrated and organized in the brainstem lateral parabrachial nucleus (LPBN), a key interoceptive sensory hub. We established methods for dense calcium imaging of 100s of neurons from mouse LPBN. Food consumption drove a seconds-long wave of activity across LPBN, with dynamics mirroring the movement of food through the upper gastrointestinal tract as observed using X-ray videofluoroscopy. By imaging the same neurons across days, we found that spatially clustered subsets of neurons encoded oral signals, stomach filling, visceral malaise, arousal, and/or body movement. Moreover, only certain subsets were modulated by cortical input. Together, these experiments establish a platform for understanding how peripheral and central interoceptive signals are integrated in the brainstem to guide behavior.},
  author       = {Essner, Rachel A. and Ruda, Kiersten and Choh, Hannah J. and Kücükdereli, Hakan and Amsalem, Oren and Edelhaus, Julia and Chahyadinata, Gracesenia and Grødem, Sverre and Lensjø, Kristian K. and Lever, Teresa E. and Andermann, Mark L.},
  issn         = {1097-4199},
  journal      = {Neuron},
  publisher    = {Cell Press},
  title        = {{Brainstem sensing of multiple body signals during food consumption}},
  doi          = {10.1016/j.neuron.2026.08.015},
  year         = {2026},
}

@article{23000,
  abstract     = {Ancient viral warfare could be at the root of modern class 1 CRISPR bacterial defense systems},
  author       = {Bravo, Jack Peter Kelly},
  issn         = {1095-9203},
  journal      = {Science},
  number       = {6817},
  pages        = {1187--1188},
  publisher    = {AAAS},
  title        = {{A viral origin for RNA-guided immunity}},
  doi          = {10.1126/science.ael0758},
  volume       = {393},
  year         = {2026},
}

@article{23043,
  abstract     = {Mendelian randomization, the standard instrument variable causal-inference approach for genomics, can be severely biased by inadequate selection of appropriate instrument variables and horizontal pleiotropy. We introduce Causal Inference GWAS, a graphical approach that selects genetic instruments from summary statistics controlling for linkage and pleiotropy, accommodates rare variants and binary outcomes, distinguishes direct from indirect risk factors in high dimensions, and flags latent confounding. Applied to 9 risk factors, 4 metabolic disease outcomes, and 8.4M variants across 458,747 UK Biobank individuals, our method runs in 20 minutes, identifying only 696 genome-wide valid instruments. We replicate nearly all previously reported risk factor-outcome paths, but find that most are indistinguishable from unmeasured confounding. This suggests robust biobank causal inference will require longitudinal and family data to resolve temporal precedence from reverse causation. Our approach offers a principled first step toward screening genuine causal signal from phenotypic correlation in biobank data.},
  author       = {Machnik, Nick N and Mahmoudi, Seyed Mahdi and Borczyk, Malgorzata and Krätschmer, Ilse and Bauer, Markus J. and Robinson, Matthew Richard},
  issn         = {2041-1723},
  journal      = {Nature Communications},
  publisher    = {Springer Nature},
  title        = {{Causal inference for multiple risk factors and diseases from genomics data}},
  doi          = {10.1038/s41467-026-76877-7},
  volume       = {17},
  year         = {2026},
}

@inproceedings{22007,
  abstract     = {Truncation of cryptographic outputs is a technique that was recently introduced in Baldimtsi et al. [Foteini Baldimtsi et al., 2022]. The general idea is to try out many inputs to some cryptographic algorithm until the output (e.g. a public-key or some hash value) falls into some sparse set and thus can be compressed: by trying out an expected 2^k different inputs one will find an output that starts with k zeros.
Using such truncation one can for example save substantial gas fees on Blockchains where storing values is very expensive. While [Foteini Baldimtsi et al., 2022] show that truncation preserves the security of the underlying primitive, they only consider a setting without preprocessing. In this work we show that lower bounds on the time-space tradeoff for inverting random functions and permutations also hold with truncation, except for parameters ranges where the bound fails to hold for "trivial" reasons.
Concretely, it’s known that any algorithm that inverts a random function or permutation with range N making T queries and using S bits of auxiliary input must satisfy S⋅ T ≥ Nlog N. This lower bound no longer holds in the truncated setting where one must only invert a challenge from a range of size N/2^k, as now one can simply save the replies to all N/2^k challenges, which requires S = log N⋅ N /2^k bits and allows to invert with T = 1 query.
We show that with truncation, whenever S is somewhat smaller than the log N⋅ N /2^k bits required to store the entire truncated function table, the known S⋅ T ≥ Nlog N lower bound applies.},
  author       = {Pietrzak, Krzysztof Z and Wang, Pengxiang},
  booktitle    = {6th Conference on Information-Theoretic Cryptography},
  isbn         = {9783959773850},
  issn         = {1868-8969},
  keywords     = {Time-Space Lower Bounds, Blockchains},
  location     = {Santa Barbara, CA, United States},
  publisher    = {Schloss Dagstuhl - Leibniz-Zentrum für Informatik},
  title        = {{Time-space tradeoffs of truncation with preprocessing}},
  doi          = {10.4230/LIPIcs.ITC.2025.4},
  volume       = {343},
  year         = {2025},
}

@article{22032,
  abstract     = {We prove that the focusing and defocusing continuum Calogero–Moser models are well-posed in the scaling-critical space L^2+(R). In the focusing case, this requires solutions to have mass less than that of the soliton.},
  author       = {Killip, Rowan and Laurens, Thierry and Visan, Monica},
  issn         = {2692-3688},
  journal      = {Communications of the American Mathematical Society},
  number       = {7},
  pages        = {284--320},
  publisher    = {American Mathematical Society},
  title        = {{Scaling-critical well-posedness for continuum Calogero–Moser models on the line}},
  doi          = {10.1090/cams/48},
  volume       = {5},
  year         = {2025},
}

@article{22036,
  abstract     = {We prove dispersive decay, pointwise in time, for solutions to the mass-critical nonlinear Schrödinger equation in spatial dimensions d= 1, 2, 3.},
  author       = {Fan, Chenjie and Killip, Rowan and Visan, Monica and Zhao, Zehua},
  issn         = {1432-1823},
  journal      = {Mathematische Zeitschrift},
  publisher    = {Springer Nature},
  title        = {{Dispersive decay for the mass-critical nonlinear Schrödinger equation}},
  doi          = {10.1007/s00209-025-03821-8},
  volume       = {311},
  year         = {2025},
}

@inproceedings{20820,
  abstract     = {The high computational costs of large language models (LLMs) have led to a flurry of research on LLM compression, via methods such as quantization, sparsification, or structured pruning. A new frontier in this area is given by dynamic, non-uniform compression methods, which adjust the compression levels (e.g., sparsity) per-block or even per-layer in order to minimize accuracy loss, while guaranteeing a global compression threshold. Yet, current methods rely on estimating the "importance" of a given layer, implicitly assuming that layers contribute independently to the overall compression error. We begin from the motivating observation that this independence assumption does not generally hold for LLM compression: pruning a model further may even significantly recover performance. To address this, we propose EvoPress, a novel evolutionary framework for dynamic LLM compression. By formulating dynamic compression as a general optimization problem, EvoPress identifies optimal compression profiles in a highly efficient manner, and generalizes across diverse models and compression techniques. Via EvoPress, we achieve state-of-the-art performance for dynamic compression of Llama, Mistral, and Phi models, setting new benchmarks for structural pruning (block/layer dropping), unstructured sparsity, and quantization with dynamic bitwidths.},
  author       = {Sieberling, Oliver and Kuznedelev, Denis and Kurtic, Eldar and Alistarh, Dan-Adrian},
  booktitle    = {42nd International Conference on Machine Learning},
  issn         = {2640-3498},
  location     = {Vancouver, Canada},
  pages        = {55556--55590},
  publisher    = {ML Research Press},
  title        = {{EvoPress: Accurate dynamic model compression via evolutionary search}},
  volume       = {267},
  year         = {2025},
}

@inproceedings{20821,
  abstract     = {Modern deep neural networks exhibit heterogeneity across numerous layers of various types such as residuals, multi-head attention, etc., due to varying structures (dimensions, activation functions, etc.), distinct representation characteristics, which impact predictions. We develop a general layer-wise quantization framework with tight variance and code-length bounds, adapting to the heterogeneities over the course of training. We then apply a new layer-wise quantization technique within distributed variational inequalities (VIs), proposing a novel Quantized Optimistic Dual Averaging (QODA) algorithm with adaptive learning rates, which achieves competitive convergence rates for monotone VIs. We empirically show that QODA achieves up to a 150% speedup over the baselines in end-to-end training time for training Wasserstein GAN on 12+GPUs.},
  author       = {Nguyen, Anh Duc and Markov, Ilia and Wu, Frank Zhengqing and Ramezani-Kebrya, Ali and Antonakopoulos, Kimon and Alistarh, Dan-Adrian and Cevher, Volkan},
  booktitle    = {42nd International Conference on Machine Learning},
  issn         = {2640-3498},
  location     = {Vancouver, Canada},
  pages        = {46026--46072},
  publisher    = {ML Research Press},
  title        = {{Layer-wise quantization for quantized optimistic dual averaging}},
  volume       = {267},
  year         = {2025},
}

@article{20839,
  abstract     = {For every couple of Hausdorff functions ψ and φ verifying some mild assumptions, there exists a compact subset K of the Baire space such that the φ-Hausdorff measure and the ψ-packing measure on K are both finite and positive. Such examples are then embedded in any infinite dimensional Banach space to answer positively a question of Fan on the existence of metric spaces with arbitrary scales.},
  author       = {Helfter, Mathieu},
  issn         = {2308-1317},
  journal      = {Journal of Fractal Geometry},
  publisher    = {EMS Press},
  title        = {{Sets with arbitrary Hausdorff and packing scales in infinite dimensional Banach spaces}},
  doi          = {10.4171/jfg/177},
  year         = {2025},
}

@misc{20842,
  abstract     = {Probing the possibility of entanglement generation through gravity offers a path to tackle the question of whether gravitational fields possess a quantum mechanical nature. A potential realization necessitates systems with low-frequency dynamics at an optimal mass scale, for which the microgram-to-milligram range is a strong contender. Here, after refining a figure-of-merit for the problem, we present a 1-milligram torsional pendulum operating at 18 Hz. We demonstrate laser cooling its motion from room temperature to 240~microkelvins, surpassing by over 20-fold the coldest motions attained for oscillators ranging from micrograms to kilograms. We quantify and contrast the utility of the current approach with other platforms. The achieved performance and large improvement potential highlight milligram-scale torsional pendulums as a powerful platform for precision measurements relevant to future studies at the quantum-gravity interface.},
  author       = {Agafonova, Sofya},
  publisher    = {Institute of Science and Technology Austria},
  title        = {{Research Data for: 'One-milligram torsional pendulum toward experiments at the quantum-gravity interface'}},
  doi          = {10.15479/AT-ISTA-20842},
  year         = {2025},
}

@inproceedings{20845,
  abstract     = {We develop new attacks against the Evasive LWE family of assumptions, in both the public and private-coin regime. To the best of our knowledge, ours are the first attacks against Evasive LWE in the public-coin regime, for any instantiation from the family. Our attacks are summarized below.

Public-Coin Attacks.
1.The recent work by Hseih, Lin and Luo [17] constructed the first Attribute Based Encryption (ABE) for unbounded depth circuits by relying on the “circular” evasive LWE assumption. This assumption has been popularly considered as a safe, public-coin instance of Evasive LWE in contrast to its “private-coin” cousins (for instance, see [10, 11]).
We provide the first attack against this assumption, challenging the widely held belief that this is a public-coin assumption.
2. We demonstrate a counter-example against vanilla public-coin evasive LWE by Wee [26] in an unnatural parameter regime. Our attack crucially relies on the error in the pre-condition being larger than the error in the post-condition, necessitating a refinement of the assumption.

Private-Coin Attacks.
1. The recent work by Agrawal, Kumari and Yamada [2] constructed the first functional encryption scheme for pseudorandom functionalities (PRFE) and extended this to obfuscation for pseudorandom functionalities (PRIO) [4] by relying on private-coin evasive LWE. We provide a new attack against the assumption stated in the first posting of their work (subsequently refined to avoid these attacks).
2. The recent work by Branco et al. [8] (concurrently to [4]) provides a construction of obfuscation for pseudorandom functionalities by relying on private-coin evasive LWE. We provide a new attack against their stated assumption.
3. Branco et al. [8] showed that there exist contrived, “self-referential” classes of pseudorandom functionalities for which pseudorandom obfuscation cannot exist. We extend their techniques to develop an analogous result for pseudorandom functional encryption.

While Evasive LWE was developed to specifically avoid “zeroizing attacks”, our work shows that in certain settings, such attacks can still apply.},
  author       = {Agrawal, Shweta and Modi, Anuja and Yadav, Anshu and Yamada, Shota},
  booktitle    = {23rd International Conference on Theory of Cryptography},
  isbn         = {9783032122926},
  issn         = {1611-3349},
  location     = {Aarhus, Denmark},
  pages        = {259--290},
  publisher    = {Springer Nature},
  title        = {{Zeroizing attacks against evasive and circular evasive LWE}},
  doi          = {10.1007/978-3-032-12293-3_9},
  volume       = {16269},
  year         = {2025},
}

@inproceedings{20846,
  abstract     = {CVRFs are PRFs that unify the properties of verifiable and constrained PRFs. Since they were introduced concurrently by Fuchsbauer and Chandran-Raghuraman-Vinayagamurthy in 2014, it has been an open problem to construct CVRFs without using heavy machinery such as multilinear maps, obfuscation or functional encryption.
We solve this problem by constructing a prefix-constrained verifiable PRF that does not rely on the aforementioned assumptions. Essentially, our construction is a verifiable version of the Goldreich-Goldwasser-Micali PRF. To achieve verifiability we leverage degree-2 algebraic PRGs and bilinear groups. In short, proofs consist of intermediate values of the Goldreich-Goldwasser-Micali PRF raised to the exponents of group elements. These outputs can be verified using pairings since the underlying PRG is of degree 2.
We prove the selective security of our construction under the Decisional Square Diffie-Hellman (DSDH) assumption and a new assumption, which we dub recursive Decisional Diffie-Hellman (recursive DDH).
We prove the soundness of recursive DDH in the generic group model assuming the hardness of the Multivariate Quadratic (MQ) problem and a new variant thereof, which we call MQ+.
Last, in terms of applications, we observe that our CVRF is also an exponent (C)VRF in the plain model. Exponent VRFs were recently introduced by Boneh et al. (Eurocrypt’25) with various applications to threshold cryptography in mind. In addition to that, we give further applications for prefix-CVRFs in the blockchain setting, namely, stake-pooling and compressible randomness beacons.},
  author       = {Brandt, Nicholas and Cueto Noval, Miguel and Günther, Christoph Ullrich and Ünal, Akin and Wohnig, Stella},
  booktitle    = {23rd International Conference on Theory of Cryptography},
  isbn         = {9783032122896},
  issn         = {1611-3349},
  location     = {Aarhus, Denmark},
  pages        = {478--511},
  publisher    = {Springer Nature},
  title        = {{Constrained verifiable random functions without obfuscation and friends}},
  doi          = {10.1007/978-3-032-12290-2_16},
  volume       = {16271},
  year         = {2025},
}

@article{20847,
  abstract     = {We report on an experimental active matter system with motion restricted to four cardinal directions. Our particles are magnetite-doped colloidal spheres driven by the Quincke electrorotational instability. The absence of a magnetic field (|𝑩|=0) leads to circular trajectories interspersed with short spontaneous runs. Intermediate fields (|𝑩|≲20mT) linearize the motion along the axis perpendicular to 𝑩. At high magnetic fields, we observe the surprising emergence of a second, distinct linearization along the axis parallel to 𝑩. With numerical simulations, we show that this behavior can be explained by anisotropic magnetic susceptibility.},
  author       = {Fitzgerald, Eavan and Clavaud, Cécile and Das, Debasish and Lenton, Isaac C and Waitukaitis, Scott R},
  issn         = {2470-0053},
  journal      = {Physical Review E},
  number       = {6},
  publisher    = {American Physical Society},
  title        = {{Rolling at right angles: Magnetic anisotropy enables dual-anisotropic active matter}},
  doi          = {10.1103/1ss8-31rb},
  volume       = {112},
  year         = {2025},
}

@article{20848,
  abstract     = {Genetic variation that influences complex disease susceptibility is introduced into the population by mutation and removed by natural selection and genetic drift. This mutation–selection–drift balance (MSDB) shapes the prevalence of a disease and its genetic architecture. To date, however, MSDB has been modeled only for monogenic (Mendelian) diseases. Here, we develop an MSDB model for complex disease susceptibility: we assume that genotype relates to disease risk according to the canonical liability threshold model and that the selection on variants affecting risk stems from the fitness cost of the disease. We focus on diseases that are highly polygenic, entail a substantial fitness cost, and are neither extremely common in the population nor exceedingly rare. The comparison of model predictions with genome-wide association studies and other observations in humans indicates that common genetic variation affecting complex disease susceptibility is little affected by directional selection and instead shaped by pleiotropic stabilizing selection on other traits. In turn, directional selection may exert a more substantial effect on rare, large-effect variants. Our results also suggest that current estimates of disease heritability are likely biased. The model thus provides a better understanding of the evolutionary processes that shape the architecture and prevalence of complex diseases.},
  author       = {Berg, Jeremy J. and Li, Xinyi and Riall, Kellen and Hayward, Laura and Sella, Guy},
  issn         = {1943-2631},
  journal      = {Genetics},
  number       = {4},
  publisher    = {Oxford University Press},
  title        = {{Mutation–selection–drift balance models of complex diseases}},
  doi          = {10.1093/genetics/iyaf220},
  volume       = {231},
  year         = {2025},
}

@article{20864,
  abstract     = {Studies of the distant Universe are providing key insights into our understanding of the formation of galaxies. The advent of the James Webb Space Telescope (JWST) has significantly enhanced our observational capabilities, leading to an expanded redshift frontier, providing unprecedented detail in the characterisation of early galaxies and enabling the discovery of new populations of accreting black holes. This review aims to provide an introduction to the basic processes and components that shape the observed spectra of galaxies, with a focus on their relevance to techniques with which high-redshift galaxies are selected. The review further introduces specific topics that have attracted significant attention in recent literature, including the discovery of highly efficient galaxy formation in the early Universe, the relation between galaxies and the process of reionization, new insights into the formation of the first stars and the enrichment of interstellar gas with heavy elements, and breakthroughs in our understanding of the origins of supermassive black holes.},
  author       = {Matthee, Jorryt J},
  issn         = {1366-5812},
  journal      = {Contemporary Physics},
  number       = {1-4},
  pages        = {116--151},
  publisher    = {Taylor & Francis},
  title        = {{JWST provides a new view of cosmic dawn: Latest developments in studies of early galaxies}},
  doi          = {10.1080/00107514.2025.2586370},
  volume       = {66},
  year         = {2025},
}

@article{20866,
  abstract     = {In this work, we present hypernode automata as a specification formalism for hyperproperties of systems whose executions may be misaligned among themselves, such as concurrent systems. These automata consist of nodes labeled with hypernode logic formulas and transitions marked with synchronizing actions. Hypernode logic formulas establish relations between sequences of variable values among different system executions. This logic enables both synchronous and asynchronous analysis of traces. In its asynchronous view on execution traces, hypernode formulas establish relations on the order of value changes for each variable without correlating their timing. In both views, the analysis of different execution traces is synchronized through the transitions of hypernode automata. By combining logic’s declarative nature with automata’s procedural power, hypernode automata seamlessly integrate asynchronicity requirements at the node level with synchronicity between node transitions. We show that the model-checking problem for hypernode automata is decidable for specifications where each node specifies either a synchronous or an asynchronous requirement for the system’s executions, but not both.},
  author       = {Bartocci, Ezio and Chalupa, Marek and Henzinger, Thomas A and Nickovic, Dejan and Oliveira da Costa, Ana},
  issn         = {1432-0525},
  journal      = {Acta Informatica},
  number       = {4},
  publisher    = {Springer Nature},
  title        = {{Hypernode automata}},
  doi          = {10.1007/s00236-025-00509-8},
  volume       = {62},
  year         = {2025},
}

@article{20867,
  abstract     = {We discuss the embeddability of subspaces of the Gromov–Hausdorff space, which consists of isometry classes of compact metric spaces endowed with the Gromov–Hausdorff distance, into Hilbert spaces. These embeddings are particularly valuable for applications to topological data analysis. We prove that its subspace consisting of metric spaces with at most n points has asymptotic dimension n(n−1)∕2. Thus, there exists a coarse embedding of that space into a Hilbert space. On the contrary, if the number of points is not bounded, then the subspace cannot be coarsely embedded into any uniformly convex Banach space and so, in particular, into any Hilbert space. Furthermore, we prove that, even if we restrict to finite metric spaces whose diameter is bounded by some constant, the subspace still cannot be bi-Lipschitz embedded into any finite-dimensional Hilbert space. We obtain both nonembeddability results by finding obstructions to coarse and bi-Lipschitz embeddings in families of isometry classes of finite subsets of the real line endowed with the Euclidean–Hausdorff distance.},
  author       = {Zava, Nicolò},
  issn         = {1472-2739},
  journal      = {Algebraic & Geometric Topology},
  number       = {8},
  pages        = {5153--5174},
  publisher    = {Mathematical Sciences Publishers},
  title        = {{Coarse and bi-Lipschitz embeddability of subspaces of the Gromov–Hausdorff space into Hilbert spaces}},
  doi          = {10.2140/agt.2025.25.5153},
  volume       = {25},
  year         = {2025},
}

@article{20868,
  abstract     = {Residents of low-latitude megacities face growing vulnerability to humid-heat stress under urbanization and global warming, yet limited research has assessed the morbidity burden of mental and behavioral disorders (MBDs) linked to humid-heat exposures in these cities. Here we quantify the hospital admissions of MBDs in Shanghai, a megacity of over 25 million inhabitants, attributable to humid heat, and project future burdens under various greenhouse gas (GHG)-emission and population scenarios. Humid heat drives a higher morbidity burden than high temperature alone, especially in humid-heat nights. Without population change, the humid-heat-related morbidity burden of MBDs would increase by 68.2% (95% empirical confidence interval 56.7%–81.6%) under the highest-GHG-emission scenario by the 2090s, while 8,465 (95% empirical confidence interval 6,928–10,053) cases would be avoided by reducing emissions to the lowest pathway. With projected population decline, the attributable hospital admissions will decrease toward century’s end. These findings highlight the benefit of GHG mitigation in reducing the growing MBD risks posed by extreme humid heat.},
  author       = {Liang, Chen and Yuan, Jiacan and Zhang, Renhe and Tang, Xu and Schumann, Gunter and Hitchen, Esther and Polemiti, Elli and Serin, Emin and Kebir, Hedi and Lett, Tristram A. and Vaidya, Nilakshi and Roy, Jean-Charles and Walter, Henrik and Heinz, Andreas and Ralser, Markus and Twardziok, Sven and Eils, Roland and Jentsch, Marcel and Taron, Ulrike-Helene and Schütz, Tatjana and Schepanski, Kerstin and Banaschewski, Tobias and Neidhart, Maja and Meyer-Lindenberg, Andreas and Tost, Heike and Holz, Nathalie and Schwarz, Emanuel and Stringaris, Argyris and Christmann, Nina and Janson, Karina and Nees, Frauke and Neidhart, Maja and Seefried, Beke and Aden, Rieke and Andreassen, Ole A. and Westlye, Lars T. and van der Meer, Dennis and Fernández-Cabello, Sara and Kjelkenes, Rikka and Ask, Helga and Rapp, Michael and Tschorn, Mira and Böttger, Sarah Jane and Marquand, Andre and Bernas, Antoine and Novarino, Gaia and Slater, Mel and Gallego, Jaime and Pastor, Álvaro and Feixas, Guillem and Eiroa-Orosa, Francisco José and Nöthen, Markus M. and Forstner, Andreas J. and Claus, Isabelle and Mathey, Carina and Heilmann-Heimbach, Stefanie and Hoffmann, Per and Miller, Abigail and Sommer, Peter and Schmitt, Karen and Wilbertz, Johannes and Patraskaki, Myrto and Jirsa, Viktor and Petkoski, Spase and Athanasiadis, Anastasios-Polykarpos and Spanlang, Bernhard and Pearmund, Charlie and Hese, Sören and Renner, Paul and Jia, Tianye and Chang, Xiao and Dai, Yuxiang and Xia, Yunman and Li, Yuzhu and Zhang, Yanqing and Calhoun, Vince and Thompson, Paul and Clinton, Nicholas and Desrivières, Sylvane and Agunbiade, Kofoworola and Yu, Xinyang and Zhang, Zuo and Chen, Di and Young, Allan H. and Schwalber, Ameli and Köhler, Vanessa and Stahl, Bernd and Ogoh, George and Schikowski, Tamara and Brandlistuen, Ragnhild},
  issn         = {2731-6076},
  journal      = {Nature Mental Health},
  number       = {12},
  pages        = {1532--1544},
  publisher    = {Springer Nature},
  title        = {{Projecting the morbidity burden of mental and behavioral disorders associated with increasing humid heat in Shanghai}},
  doi          = {10.1038/s44220-025-00519-y},
  volume       = {3},
  year         = {2025},
}