@unpublished{21696, abstract = {We demonstrate an integrated photonic circuit based on feed forward photonic meshes that can be programmed and reconfigured to perform arbitrary spectral filter functions. We investigate a subset of the available filter functions, demonstrating that a N = 4 input triangular mesh with M = 3 layers may be operated via self-configuration algorithms to filter M arbitrary wavelengths from a given input spectrum. The tunable nature of the architecture enables preconfigured filter functions to be swept in the spectral domain continuously over the free spectral range of the device. This removes any strict requirements between the design parameters of the architecture and the center wavelength of a desired filter function. With this architecture, we experimentally demonstrate arbitrary wavelength rejection filters with contrasts as deep as 40 dB. Further, by intentionally selecting the center wavelengths of each filter function to lie along a wavelength grid we demonstrate deep wavelength division demultiplexing (DWDM) with inter-channel crosstalk between -25 dB and -40 dB. Unlike typical DWDM systems, in this architecture the center wavelength of each channel is not fixed at fabrication and instead may be swept or reordered arbitrarily. This device demonstrates advantages over typical methods for DWDM, Raman spectroscopy, and correlation spectroscopy as well as other applications.}, author = {Valdez, Carson G. and Kroo, Anne R. and Vlk, Marek and Roques-Carmes, Charles and Fan, Shanhui and Miller, David A. B. and Solgaard, Olav}, booktitle = {arXiv}, title = {{Programmable optical filters based on feed-forward photonic meshes}}, doi = {10.48550/arXiv.2509.12059}, year = {2025}, } @unpublished{21697, abstract = {Integrated multimode quantum optics is a promising platform for scalable continuous-variable quantum technologies leveraging multimode squeezing in both the spatial and spectral domains. However, on-chip measurement, routing and processing the relevant ``supermodes'' over which the squeezing resource is distributed still scales quadratically with the number of modes $N$, causing rapid increase in photonic circuit size and number of required measurements. Here, we introduce a variational scheme, relying on self-configuring photonic networks (SCN) that learns and extracts the most-squeezed supermodes sequentially, reducing both the circuit size and the experimental overhead. Using homodyne measurement as a cost function, a sparse SCN discovers the $l\ll N$ most significant supermodes using $O(lN)$ physical elements and optimization steps. We analyze and numerically simulate these architectures for both real-space and frequency-domain implementations, showing a fidelity close to unity between the learned circuit and the supermode decomposition, even in the presence of optical losses and detection noise. In the frequency domain, we show that circuit size can be further reduced by using inverse-designed surrogate networks, which emulate the layers learned thus far. Using two different frequency encoding schemes -- uniformly- and non-uniformly-spaced frequency bins -- we reduce an entire network (learning all $N$ supermodes) to $O(N)$ and even $O(1)$ modulated cavities. Our results point toward chip-scale, resource-efficient quantum processing units and demultiplexers for continuous variable processing in multimode quantum optics, with applications ranging from quantum communication, metrology, and computation.}, author = {Karnieli, Aviv and Mor, Paul-Alexis and Roques-Carmes, Charles and Lustig, Eran and Sloan, Jamison and Vučković, Jelena and Miller, David A. B. and Fan, Shanhui}, booktitle = {arXiv}, title = {{Variational processing of multimode squeezed light}}, doi = {10.48550/arXiv.2509.16753}, year = {2025}, } @article{21706, abstract = {Consider a quadratic polynomial Q(ξ1, . . . , ξn) of independent Rademacher random variables ξ1, . . . , ξn. To what extent can Q(ξ1, . . . , ξn) concentrate on a single value? This quadratic version of the classical Littlewood–Offord problem was popularised by Costello, Tao and Vu in their study of symmetric random matrices. In this paper, we obtain an essentially optimal bound for this problem, as conjectured by Nguyen and Vu. Specifically, if Q(ξ1, . . . , ξn) ‘robustly depends on at least m of the ξi’ in the sense that there is no way to pin down the value of Q(ξ1, . . . , ξn) by fixing values for fewer than m of the variables ξi, then we have Pr[Q(ξ1, . . . , ξn) = 0] ≤ O(1/√m). This also implies a similar result in the case where ξ1, . . . , ξn have arbitrary distributions. Our proof combines a number of ideas that may be of independent interest, including an inductive decoupling scheme that reduces quadratic anticoncentration problems to high-dimensional linear anticoncentration problems. Also, one application of our main result is the resolution of a conjecture of Alon, Hefetz, Krivelevich and Tyomkyn related to graph inducibility. }, author = {Kwan, Matthew Alan and Sauermann, Lisa}, issn = {1570-5846}, journal = {Compositio Mathematica}, number = {12}, pages = {3089--3139}, publisher = {Cambridge University Press}, title = {{Resolution of the quadratic Littlewood–Offord problem}}, doi = {10.1112/S0010437X25102789}, volume = {161}, year = {2025}, } @article{21724, abstract = {The next generation of weak-gravitational-lensing surveys has the potential to place stringent constraints on cosmological parameters. However, their analysis is limited by systematics such as the intrinsic alignments of galaxies, which alter weak-lensing convergence and can lead to biases in cosmological parameter estimations. For the first time, in this work, we investigate the impact of intrinsic alignments on non-Gaussian statistics of the weak-lensing field using galaxy shapes derived from the IllustrisTNG hydrodynamical simulation. We create two catalogs of ray-traced convergence maps: one that includes the measured intrinsic shape of each galaxy and another where all galaxies are randomly rotated to eliminate intrinsic alignments. We compare a range of weak-lensing statistics between the two catalogs, including the shear–shear correlation function, the map-level angular power spectrum, one-point, peak count, and minimum distribution functions, and Minkowski functionals. For each statistic, we assess the level of statistical distinguishability between catalogs for a set of future survey angular areas. Our results reveal strong small-scale correlation in the alignment of galaxies and statistically significant boosts in weak-lensing convergence in both positive and negative directions for high-significance peaks and minima, respectively. We note that our analysis is at a fixed number density of ˜ 5 arcmin^-2, drawn from a single realization of initial conditions, and does not include observational uncertainties or supersample covariance contributions. Weak-lensing analyses utilizing non-Gaussian statistics must account for intrinsic alignments to avoid significantly compromised cosmological inferences.}, author = {Lee, Max E. and Haiman, Zoltán and Pandey, Shivam and Genel, Shy}, issn = {1538-4357}, journal = {The Astrophysical Journal}, number = {1}, publisher = {IOP Publishing}, title = {{The effect of intrinsic alignments on weak-lensing statistics in hydrodynamical simulations}}, doi = {10.3847/1538-4357/ae1ca7}, volume = {996}, year = {2025}, } @article{21727, abstract = {We present a comprehensive analysis of the MIRI Extremely Red Object Virgil, a Lyα emitter at zspec = 6.6379 ± 0.0035 with the photometric properties of a Little Red Dot. Leveraging new JWST/MIRI imaging from the MIDIS and PAHSPECS programs, we confirm Virgil’s extraordinary nature among galaxies in JADES/GOODS-South, exhibiting a strikingly red NIRCam-to-MIRI color (F444W–F1500W = 2.84 ± 0.04 mag). Deep NIRSpec/PRISM spectroscopy from the OASIS program offers key insights into the host galaxy, revealing properties of an average star-forming galaxy during Cosmic Reionization, such as a subsolar metallicity, low-to-moderate dust content, and a relatively high ionization parameter and electron temperature. By estimating the star formation rate of Virgil from UV and Hα, we find evidence that the galaxy is either entering or fading out of a bursty episode. Although line-ratio diagnostics employed at high z would classify Virgil as an active galactic nucleus (AGN), this classification becomes ambiguous once redshift evolution is considered. Nonetheless, Virgil occupies the same parameter space as recently confirmed AGNs at similar redshifts. The new deep MIRI data at 15 μm reinforce the AGN nature of Virgil, as inferred from multiple spectral energy distribution (SED) fitting codes. Virgil’s rising infrared SED and UV excess resemble those of Dust-Obscured Galaxies (DOGs) studied with Spitzer at Cosmic Noon, particularly blue-excess HotDOGs. Our results highlight the need for a multiwavelength approach incorporating MIRI to uncover such extreme sources at z ≳ 6 and to shed light on the interplay between galaxy evolution and early black hole growth during Cosmic Reionization.}, author = {Rinaldi, Pierluigi and Pérez-González, Pablo G. and Rieke, George H. and Lyu, Jianwei and D’Eugenio, Francesco and Wu, Zihao and Carniani, Stefano and Looser, Tobias J. and Shivaei, Irene and Boogaard, Leindert A. and Diaz-Santos, Tanio and Colina, Luis and Östlin, Göran and Alberts, Stacey and Álvarez-Márquez, Javier and Annuziatella, Marianna and Aravena, Manuel and Bhatawdekar, Rachana and Bunker, Andrew J. and Caputi, Karina I. and Charlot, Stéphane and Crespo Gómez, Alejandro and Curti, Mirko and Eckart, Andreas and Gillman, Steven and Hainline, Kevin and Kumari, Nimisha and Hjorth, Jens and Iani, Edoardo and Inami, Hanae and Ji, Zhiyuan and Johnson, Benjamin D. and Jones, Gareth C. and Labiano, Álvaro and Maiolino, Roberto and Melinder, Jens and Moutard, Thibaud and Peissker, Florian and Rieke, Marcia and Robertson, Brant and Scholtz, Jan and Tacchella, Sandro and Van Der Werf, Paul P. and Walter, Fabian and Williams, Christina C. and Willott, Chris and Witstok, Joris and Übler, Hannah and Zhu, Yongda}, issn = {1538-4357}, journal = {The Astrophysical Journal}, number = {1}, publisher = {IOP Publishing}, title = {{Deciphering the nature of Virgil: An obscured active galactic nucleus lurking within an apparently normal Lyα emitter during cosmic reionization}}, doi = {10.3847/1538-4357/ae089c}, volume = {994}, year = {2025}, } @inproceedings{21885, abstract = {Symbolic datatypes have proved to be central for automated reasoning about dynamical systems. In its basic form, a symbolic datatype for a class of dynamical systems supports the representation of state and transition sets, boolean operations and emptiness checks on such sets, and the transformation of a state set by a transition set. Successful examples of symbolic datatypes include BDDs and SAT for reasoning about finitestate systems, as well as polyhedra and SMT for reasoning about discrete dynamical systems over multidimensional realvalued state spaces. Most automated verification engines are based on such symbolic datatypes.}, author = {Henzinger, Thomas A}, booktitle = {Proceedings of the 27th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing}, issn = {2470-881X}, location = {Timisoara, Romania}, publisher = {IEEE}, title = {{Neural Certificates}}, doi = {10.1109/SYNASC69064.2025.00008}, year = {2025}, } @article{21912, abstract = {The mammalian fatty acid synthase (FASN) enzyme is a dynamic multienzyme that belongs to the megasynthase family. In mammals, a single gene encodes six catalytically active domains and a flexibly tethered acyl carrier protein (ACP) domain that shuttles intermediates between active sites for fatty acid biosynthesis1. FASN is an essential enzyme in mammalian development through the role that fatty acids have in membrane formation, energy storage, cell signalling and protein modifications. Thus, FASN is a promising target for treatment of a large variety of diseases including cancer, metabolic dysfunction-associated fatty liver disease, and viral and parasite infections2,3. The multi-faceted mechanism of FASN and the dynamic nature of the protein, in particular of the ACP, have made it challenging to understand at the molecular level. Here we report cryo-electron microscopy structures of human FASN in a multitude of conformational states with NADPH and NADP+ plus acetoacetyl-CoA present, including structures with the ACP stalled at the dehydratase (DH) and enoyl-reductase (ER) domains. We show that FASN activity in vitro and de novo lipogenesis in cells is inhibited by mutations at the ACP–DH and ACP–ER interfaces. Together, these studies provide new molecular insights into the dynamic nature of FASN and the ACP shuttling mechanism, with implications for developing improved FASN-targeted therapeutics.}, author = {Schultz, Kollin and Costa-Pinheiro, Pedro and Gardner, Lauren and Pinheiro, Laura V. and Ramirez-Solis, Julio and Gardner, Sarah M. and Wellen, Kathryn E. and Marmorstein, Ronen}, issn = {1476-4687}, journal = {Nature}, number = {8062}, pages = {520--528}, publisher = {Springer Nature}, title = {{Snapshots of acyl carrier protein shuttling in human fatty acid synthase}}, doi = {10.1038/s41586-025-08587-x}, volume = {641}, year = {2025}, } @unpublished{21920, abstract = {Vertebrates display remarkable diversity of sensorimotor behaviors, each adapted to distinct ecological and survival demands. This diversity raises fundamental questions about the evolutionary origin of motor control: do conserved spinal circuits underlie these behaviors, and how have they diverged across species. Recent studies detail spinal cell-type architecture in mammals but comparable, high-resolution atlases of the non-mammalian spinal cord are lacking. Here, we compare spinal cord cell types between fish, frogs, mice and humans, spanning ∼450 million years of evolution. Across species, we define highly conserved programs of cell type specification that segregate spinal neurons into nearly identical cardinal classes during development. This contrasts with adult stages, when spinal cell-type composition selectively diverges for excitatory neuron subpopulations. Using spatial transcriptomics, we localize this species divergence to the superficial, dorsal spinal cord, where variant neuropeptide expression defines mammalian-specific cell types. The most dorsal spinal cord thus emerges as a recently evolved hub for sensory integration in mammals, a neospinal cord analogous to the neocortex.}, author = {Ignatyev, Yuri and Papadopoulos, Stavros and Soretić, Mateja and Yeung, Jake and Lin, Tzi-Yang and Tanaka, Elly M and Peshkin, Leonid and Levine, Ariel J and Gabitto, Mariano I and Sweeney, Lora Beatrice Jaeger}, booktitle = {bioRxiv}, title = {{Innovations in spinal cord cell type heterogeneity across vertebrate evolution}}, doi = {10.1101/2025.10.09.680955}, year = {2025}, } @article{14647, abstract = {In the developing vertebrate central nervous system, neurons and glia typically arise sequentially from common progenitors. Here, we report that the transcription factor Forkhead Box G1 (Foxg1) regulates gliogenesis in the mouse neocortex via distinct cell-autonomous roles in progenitors and postmitotic neurons that regulate different aspects of the gliogenic FGF signalling pathway. We demonstrate that loss of Foxg1 in cortical progenitors at neurogenic stages causes premature astrogliogenesis. We identify a novel FOXG1 target, the pro-gliogenic FGF pathway component Fgfr3, which is suppressed by FOXG1 cell-autonomously to maintain neurogenesis. Furthermore, FOXG1 can also suppress premature astrogliogenesis triggered by the augmentation of FGF signalling. We identify a second novel function of FOXG1 in regulating the expression of gliogenic cues in newborn neocortical upper-layer neurons. Loss of FOXG1 in postmitotic neurons non-autonomously enhances gliogenesis in the progenitors via FGF signalling. These results fit well with the model that newborn neurons secrete cues that trigger progenitors to produce the next wave of cell types, astrocytes. If FGF signalling is attenuated in Foxg1 null progenitors, they progress to oligodendrocyte production. Therefore, loss of FOXG1 transitions the progenitor to a gliogenic state, producing either astrocytes or oligodendrocytes depending on FGF signalling levels. Our results uncover how FOXG1 integrates extrinsic signalling via the FGF pathway to regulate the sequential generation of neurons, astrocytes, and oligodendrocytes in the cerebral cortex. }, author = {Bose, Mahima and Suresh, Varun and Mishra, Urvi and Talwar, Ishita and Yadav, Anuradha and Biswas, Shiona and Hippenmeyer, Simon and Tole, Shubha}, issn = {2050-084X}, journal = {eLife}, publisher = {eLife Sciences Publications}, title = {{Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signalling pathway}}, doi = {10.7554/elife.101851.3}, volume = {13}, year = {2025}, } @article{15121, abstract = {We present an auction algorithm using multiplicative instead of constant weight updates to compute a (1-E)-approximate maximum weight matching (MWM) in a bipartite graph with n vertices and m edges in time 0(mE-1), beating the running time of the fastest known approximation algorithm of Duan and Pettie [JACM ’14] that runs in 0(mE-1 log E-1). Our algorithm is very simple and it can be extended to give a dynamic data structure that maintains a (1-E)-approximate maximum weight matching under (1) one-sided vertex deletions (with incident edges) and (2) one-sided vertex insertions (with incident edges sorted by weight) to the other side. The total time time used is 0(mE-1), where m is the sum of the number of initially existing and inserted edges.}, author = {Zheng, Da Wei and Henzinger, Monika H}, issn = {1436-4646}, journal = {Mathematical Programming}, pages = {881--894}, publisher = {Springer Nature}, title = {{Multiplicative auction algorithm for approximate maximum weight bipartite matching}}, doi = {10.1007/s10107-024-02066-3}, volume = {210}, year = {2025}, } @article{15128, abstract = {We prove a universal mesoscopic central limit theorem for linear eigenvalue statistics of a Wigner-type matrix inside the bulk of the spectrum with compactly supported twice continuously differentiable test functions. The main novel ingredient is an optimal local law for the two-point function $T(z,\zeta)$ and a general class of related quantities involving two resolvents at nearby spectral parameters.}, author = {Riabov, Volodymyr}, issn = {0246-0203}, journal = {Annales de l'institut Henri Poincare (B) Probability and Statistics}, number = {1}, pages = {129--154}, publisher = {Institute of Mathematical Statistics}, title = {{Mesoscopic eigenvalue statistics for Wigner-type matrices}}, doi = {10.1214/23-AIHP1438}, volume = {61}, year = {2025}, } @article{17094, abstract = {Contract-based design is a promising methodology for taming the complexity of developing sophisticated systems. A formal contract distinguishes between assumptions, which are constraints that the designer of a component puts on the environments in which the component can be used safely, and guarantees, which are promises that the designer asks from the team that implements the component. A theory of formal contracts can be formalized as an interface theory, which supports the composition and refinement of both assumptions and guarantees. Although there is a rich landscape of contract-based design methods that address functional and extra-functional properties, we present the first interface theory designed to ensure system-wide security properties. Our framework provides a refinement relation and a composition operation that support both incremental design and independent implementability. We develop our theory for both stateless and stateful interfaces. Additionally, we introduce information-flow contracts where assumptions and guarantees are sets of flow relations. We use these contracts to illustrate how to enrich information-flow interfaces with a semantic view. We illustrate the applicability of our framework with two examples inspired by the automotive domain.}, author = {Bartocci, Ezio and Ferrere, Thomas and Henzinger, Thomas A and Nickovic, Dejan and Oliveira da Costa, Ana}, issn = {1572-8102}, journal = {Formal Methods in System Design}, pages = {3--48}, publisher = {Springer Nature}, title = {{Information-flow interfaces}}, doi = {10.1007/s10703-024-00447-0}, volume = {66}, year = {2025}, } @article{18478, abstract = {For a given graph G=(V,E), we define its \emph{nth subdivision} as the graph obtained from G by replacing every edge by a path of length n. We also define the \emph{mth power} of G as the graph on vertex set V where we connect every pair of vertices at distance at most m in G. In this paper, we study the chromatic number of powers of subdivisions of graphs and resolve the case m=n asymptotically. In particular, our result confirms a conjecture of Mozafari-Nia and Iradmusa in the case m=n=3 in a strong sense.}, author = {Anastos, Michael and Boyadzhiyska, Simona and Rathke, Silas and Rué, Juanjo}, issn = {0166-218X}, journal = {Discrete Applied Mathematics}, pages = {506--511}, publisher = {Elsevier}, title = {{On the chromatic number of powers of subdivisions of graphs}}, doi = {10.1016/j.dam.2024.10.002}, volume = {360}, year = {2025}, } @article{18529, abstract = {Temporal networks are obtained from time-dependent interactions among individuals, whereas the interactions can be emails, phone calls, face-to-face meetings, or work collaboration. In this article, a temporal game framework is established, in which interactions among rational individuals are embedded into two-player games in a time-dependent manner. This allows studying the time-dependent complexity and variability of interactions, and the way they affect prosocial behaviors. Based on this simple mathematical model, it is found that the level of cooperation is promoted when the time of collaboration is equally limited for every individual. This observation is confirmed by a series of systematic human experiments on over 1,400 subjects, forming a foundation for comprehensively describing human temporal interactions in collaboration. The research results reveal an important incentive for human cooperation, leading to a better understanding of a fascinating aspect of human nature in society.}, author = {Zhang, Yichao and Wang, Jiasheng and Wen, Guanghui and Guan, Jihong and Zhou, Shuigeng and Chen, Guanrong and Chatterjee, Krishnendu and Perc, Matjaz}, issn = {2327-4697}, journal = {IEEE Transactions on Network Science and Engineering}, number = {1}, pages = {4--12}, publisher = {IEEE}, title = {{Limitation of time promotes cooperation in structured collaboration systems}}, doi = {10.1109/TNSE.2024.3481434}, volume = {12}, year = {2025}, } @article{18558, abstract = {The current investigation presents a facile and cost-effective sol-gel approach for the synthesis of phase-pure multiferroic bismuth ferrite (BiFeO3) nanoparticles (BFO NPs) by using propylene glycol as a complexing agent, intended for use as a photocatalyst to efficiently degrade organic dyes in aqueous solutions under natural sunlight. Characterization techniques, including thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD), elucidated a plausible reaction pathway for the formation of phase-pure BFO NPs. Rietveld refinement of the XRD data, in conjunction with transmission electron microscopy (TEM) and Raman spectroscopy, confirmed the synthesis of single-phase BFO NPs at 400 °C, displaying a space group of R3c and an average crystallite size of 25 nm. UV–visible diffuse reflectance spectroscopy revealed an absorption cut-off wavelength near 590 nm, corresponding to a band gap of 2.08 eV, indicating the capability of BFO NPs to absorb visible light within the 400–590 nm range. BFO NPs have shown efficient and rapid photocatalytic degradation of methylene blue (MB) in acidic, neutral, and basic pH conditions under natural sunlight. This is attributed to the intrinsic ferroelectric and ferromagnetic ordering present in synthesized BFO NPs which facilitates the separation and migration of photoinduced charges through band bending phenomena at the interface.}, author = {Verma, Madhu and Kumar, Ajay and Thakur, Vijay Kumar and Maurya, Akanksha and Kumar, Sachin and Singh, Saurabh and Srivastav, Simant Kumar}, issn = {1573-4846}, journal = {Journal of Sol-Gel Science and Technology}, pages = {356--373}, publisher = {Springer Nature}, title = {{Efficient and rapid sunlight-driven photocatalytic degradation of methylene blue dye using multiferroic BiFeO3 nanoparticles}}, doi = {10.1007/s10971-024-06607-2}, volume = {113}, year = {2025}, } @article{18580, abstract = {Motivated by the study of recurrent orbits and dynamics within a Morse set of a Morse decomposition we introduce the concept of Morse predecomposition of an isolated invariant set within the setting of both combinatorial and classical dynamical systems. While Morse decomposition summarizes solely the gradient part of a dynamical system, the developed generalization extends to the recurrent component as well. In particular, a chain recurrent set, which is indecomposable in terms of Morse decomposition, can be represented more finely in the Morse predecomposition framework. This generalization is achieved by forgoing the poset structure inherent to Morse decomposition and relaxing the notion of connection between Morse sets (elements of Morse decomposition) in favor of what we term ’links’. We prove that a Morse decomposition is a special case of Morse predecomposition indexed by a poset. Additionally, we show how a Morse predecomposition may be condensed back to retrieve a Morse decomposition.}, author = {Lipiński, Michał and Mischaikow, Konstantin and Mrozek, Marian}, issn = {1662-3592}, journal = {Qualitative Theory of Dynamical Systems}, number = {1}, publisher = {Springer Nature}, title = {{Morse predecomposition of an invariant set}}, doi = {10.1007/s12346-024-01144-3}, volume = {24}, year = {2025}, } @article{18619, abstract = {Brassinosteroids (BRs) are steroidal phytohormones indispensable for plant growth, development, and responses to environmental stresses. The export of bioactive BRs to the apoplast is essential for BR signalling initiation, which requires binding of BR molecule to the extracellular domains of the plasma membrane-localized receptor complex. We have previously shown that the Arabidopsis thaliana ATP-binding cassette (ABC) transporter, ABCB19, functions as a BR exporter, and together with its close homologue, ABCB1, positively regulate BR signalling. Here, we demonstrate that ABCB1 is another BR transporter. The ATP hydrolysis activity of ABCB1 was stimulated by bioactive BRs, and its transport activity was confirmed in proteoliposomes and protoplasts. Structures of ABCB1 in substrate-unbound (apo), brassinolide (BL)-bound, and ATP plus BL-bound states were determined. In the BL-bound structure, BL was bound to the hydrophobic cavity formed by the transmembrane domain, and triggered local conformational changes. Together, our data provide additional insights into the ABC transporter-mediated BR export.}, author = {Wei, H and Zhu, H and Ying, W and Janssens, H and Kvasnica, M and Winne, JM and Gao, Y and Friml, Jiří and Ma, Q and Tan, S and Liu, X and Russinova, E and Sun, L}, issn = {2590-3462}, journal = {Plant Communications}, number = {1}, publisher = {Elsevier}, title = {{Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1}}, doi = {10.1016/j.xplc.2024.101181}, volume = {6}, year = {2025}, } @article{18626, abstract = {The local angle property of the (order-1) Delaunay triangulations of a generic set in R2 asserts that the sum of two angles opposite a common edge is less than π. This paper extends this property to higher order and uses it to generalize two classic properties from order-1 to order-2: (1) among the complete level-2 hypertriangulations of a generic point set in R2, the order-2 Delaunay triangulation lexicographically maximizes the sorted angle vector; (2) among the maximal level-2 hypertriangulations of a generic point set in R2, the order-2 Delaunay triangulation is the only one that has the local angle property. We also use our method of establishing (2) to give a new short proof of the angle vector optimality for the (order-1) Delaunay triangulation. For order-1, both properties have been instrumental in numerous applications of Delaunay triangulations, and we expect that their generalization will make order-2 Delaunay triangulations more attractive to applications as well.}, author = {Edelsbrunner, Herbert and Garber, Alexey and Saghafian, Morteza}, issn = {1090-2082}, journal = {Advances in Mathematics}, publisher = {Elsevier}, title = {{Order-2 Delaunay triangulations optimize angles}}, doi = {10.1016/j.aim.2024.110055}, volume = {461}, year = {2025}, } @article{18631, abstract = {Within the established framework of structure formation, galaxies start as systems of low stellar mass and gradually grow into far more massive galaxies. The existence of massive galaxies in the first billion years of the Universe, as suggested by recent observations, seems to challenge this model, as such galaxies would require highly efficient conversion of baryons into stars. An even greater challenge in this epoch is the existence of massive galaxies that have already ceased forming stars. However, robust detections of early massive quiescent galaxies have been challenging due to the coarse wavelength sampling of photometric surveys. Here we report the spectroscopic confirmation with the James Webb Space Telescope of the quiescent galaxy RUBIES-EGS-QG-1 at redshift z = 4.90, 1.2 billion years after the Big Bang. Deep stellar absorption features in the spectrum reveal that the stellar mass of the galaxy of 1011 M⊙ formed in a short 200 Myr burst of star formation, after which star formation activity dropped rapidly and persistently. According to current galaxy formation models, systems with such rapid stellar mass growth and early quenching are too rare to plausibly occur in the small area probed spectroscopically with JWST. Instead, the discovery of RUBIES-EGS-QG-1 implies that early massive quiescent galaxies can be quenched earlier or exhaust gas available for star formation more efficiently than assumed at present.}, author = {De Graaff, Anna and Setton, David J. and Brammer, Gabriel and Cutler, Sam and Suess, Katherine A. and Labbé, Ivo and Leja, Joel and Weibel, Andrea and Maseda, Michael V. and Whitaker, Katherine E. and Bezanson, Rachel and Boogaard, Leindert A. and Cleri, Nikko J. and De Lucia, Gabriella and Franx, Marijn and Greene, Jenny E. and Hirschmann, Michaela and Matthee, Jorryt J and Mcconachie, Ian and Naidu, Rohan P. and Oesch, Pascal A. and Price, Sedona H. and Rix, Hans Walter and Valentino, Francesco and Wang, Bingjie and Williams, Christina C.}, issn = {2397-3366}, journal = {Nature Astronomy}, pages = {280--292}, publisher = {Springer Nature}, title = {{Efficient formation of a massive quiescent galaxy at redshift 4.9}}, doi = {10.1038/s41550-024-02424-3}, volume = {9}, year = {2025}, } @article{18632, abstract = {For an arbitrary dimension (Formula presented.), we study: the polyharmonic Gaussian field (Formula presented.) on the discrete torus (Formula presented.), that is the random field whose law on (Formula presented.) given by (Formula presented.) where (Formula presented.) is the Lebesgue measure and (Formula presented.) is the discrete Laplacian; the associated discrete Liouville quantum gravity (LQG) measure associated with it, that is, the random measure on (Formula presented.) (Formula presented.) where (Formula presented.) is a regularity parameter. As (Formula presented.), we prove convergence of the fields (Formula presented.) to the polyharmonic Gaussian field (Formula presented.) on the continuous torus (Formula presented.), as well as convergence of the random measures (Formula presented.) to the LQG measure (Formula presented.) on (Formula presented.), for all (Formula presented.). }, author = {Dello Schiavo, Lorenzo and Herry, Ronan and Kopfer, Eva and Sturm, Karl Theodor}, issn = {1522-2616}, journal = {Mathematische Nachrichten}, number = {1}, pages = {244--281}, publisher = {Wiley}, title = {{Polyharmonic fields and Liouville quantum gravity measures on tori of arbitrary dimension: From discrete to continuous}}, doi = {10.1002/mana.202400169}, volume = {298}, year = {2025}, }