@article{22052,
  abstract     = {We consider the focusing cubic nonlinear Schrödinger equation (NLS) in the exterior Ω of a smooth, compact, strictly convex obstacle in three dimensions. We prove that the threshold for global existence and scattering is the same as for the problem posed on Euclidean space. Specifically, we prove that if E(u0)M(u0)<E(Q)M(Q) and ||u0||2||u0||2<\|\nabla Q||2||Q||2, the corresponding solution to the initial value problem with Dirichlet boundary conditions exists globally and scatters to linear evolutions asymptotically in the future and in the past. Here, Q(x) denotes the ground state for the focusing cubic NLS in ℝ3. },
  author       = {Killip, Rowan and Visan, Monica and Zhang, Xiaoyi},
  issn         = {1687-1197},
  journal      = {Applied Mathematics Research eXpress},
  number       = {1},
  pages        = {146--180},
  publisher    = {Oxford University Press},
  title        = {{The focusing cubic NLS on exterior domains in three dimensions}},
  doi          = {10.1093/amrx/abv012},
  volume       = {2016},
  year         = {2016},
}

@article{1100,
  abstract     = {During metazoan development, the temporal pattern of morphogen signaling is critical for organizing cell fates in space and time. Yet, tools for temporally controlling morphogen signaling within the embryo are still scarce. Here, we developed a photoactivatable Nodal receptor to determine how the temporal pattern of Nodal signaling affects cell fate specification during zebrafish gastrulation. By using this receptor to manipulate the duration of Nodal signaling in vivo by light, we show that extended Nodal signaling within the organizer promotes prechordal plate specification and suppresses endoderm differentiation. Endoderm differentiation is suppressed by extended Nodal signaling inducing expression of the transcriptional repressor goosecoid (gsc) in prechordal plate progenitors, which in turn restrains Nodal signaling from upregulating the endoderm differentiation gene sox17 within these cells. Thus, optogenetic manipulation of Nodal signaling identifies a critical role of Nodal signaling duration for organizer cell fate specification during gastrulation.},
  author       = {Sako, Keisuke and Pradhan, Saurabh and Barone, Vanessa and Inglés Prieto, Álvaro and Mueller, Patrick and Ruprecht, Verena and Capek, Daniel and Galande, Sanjeev and Janovjak, Harald L and Heisenberg, Carl-Philipp J},
  journal      = {Cell Reports},
  number       = {3},
  pages        = {866 -- 877},
  publisher    = {Cell Press},
  title        = {{Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation}},
  doi          = {10.1016/j.celrep.2016.06.036},
  volume       = {16},
  year         = {2016},
}

@article{1321,
  abstract     = {Most migrating cells extrude their front by the force of actin polymerization. Polymerization requires an initial nucleation step, which is mediated by factors establishing either parallel filaments in the case of filopodia or branched filaments that form the branched lamellipodial network. Branches are considered essential for regular cell motility and are initiated by the Arp2/3 complex, which in turn is activated by nucleation-promoting factors of the WASP and WAVE families. Here we employed rapid amoeboid crawling leukocytes and found that deletion of the WAVE complex eliminated actin branching and thus lamellipodia formation. The cells were left with parallel filaments at the leading edge, which translated, depending on the differentiation status of the cell, into a unipolar pointed cell shape or cells with multiple filopodia. Remarkably, unipolar cells migrated with increased speed and enormous directional persistence, while they were unable to turn towards chemotactic gradients. Cells with multiple filopodia retained chemotactic activity but their migration was progressively impaired with increasing geometrical complexity of the extracellular environment. These findings establish that diversified leading edge protrusions serve as explorative structures while they slow down actual locomotion.},
  author       = {Leithner, Alexander F and Eichner, Alexander and Müller, Jan and Reversat, Anne and Brown, Markus and Schwarz, Jan and Merrin, Jack and De Gorter, David and Schur, Florian and Bayerl, Jonathan and De Vries, Ingrid and Wieser, Stefan and Hauschild, Robert and Lai, Frank and Moser, Markus and Kerjaschki, Dontscho and Rottner, Klemens and Small, Victor and Stradal, Theresia and Sixt, Michael K},
  journal      = {Nature Cell Biology},
  pages        = {1253 -- 1259},
  publisher    = {Nature Publishing Group},
  title        = {{Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes}},
  doi          = {10.1038/ncb3426},
  volume       = {18},
  year         = {2016},
}

@article{1183,
  abstract     = {Autism spectrum disorders (ASD) are a group of genetic disorders often overlapping with other neurological conditions. We previously described abnormalities in the branched-chain amino acid (BCAA) catabolic pathway as a cause of ASD. Here, we show that the solute carrier transporter 7a5 (SLC7A5), a large neutral amino acid transporter localized at the blood brain barrier (BBB), has an essential role in maintaining normal levels of brain BCAAs. In mice, deletion of Slc7a5 from the endothelial cells of the BBB leads to atypical brain amino acid profile, abnormal mRNA translation, and severe neurological abnormalities. Furthermore, we identified several patients with autistic traits and motor delay carrying deleterious homozygous mutations in the SLC7A5 gene. Finally, we demonstrate that BCAA intracerebroventricular administration ameliorates abnormal behaviors in adult mutant mice. Our data elucidate a neurological syndrome defined by SLC7A5 mutations and support an essential role for the BCAA in human brain function.},
  author       = {Tarlungeanu, Dora-Clara and Deliu, Elena and Dotter, Christoph and Kara, Majdi and Janiesch, Philipp and Scalise, Mariafrancesca and Galluccio, Michele and Tesulov, Mateja and Morelli, Emanuela and Sönmez, Fatma and Bilgüvar, Kaya and Ohgaki, Ryuichi and Kanai, Yoshikatsu and Johansen, Anide and Esharif, Seham and Ben Omran, Tawfeg and Topcu, Meral and Schlessinger, Avner and Indiveri, Cesare and Duncan, Kent and Caglayan, Ahmet and Günel, Murat and Gleeson, Joseph and Novarino, Gaia},
  journal      = {Cell},
  number       = {6},
  pages        = {1481 -- 1494},
  publisher    = {Cell Press},
  title        = {{Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder}},
  doi          = {10.1016/j.cell.2016.11.013},
  volume       = {167},
  year         = {2016},
}

@inproceedings{1437,
  abstract     = {We study algorithmic questions for concurrent systems where the transitions are labeled from a complete, closed semiring, and path properties are algebraic with semiring operations. The algebraic path properties can model dataflow analysis problems, the shortest path problem, and many other natural problems that arise in program analysis. We consider that each component of the concurrent system is a graph with constant treewidth, a property satisfied by the controlflow graphs of most programs. We allow for multiple possible queries, which arise naturally in demand driven dataflow analysis. The study of multiple queries allows us to consider the tradeoff between the resource usage of the one-time preprocessing and for each individual query. The traditional approach constructs the product graph of all components and applies the best-known graph algorithm on the product. In this approach, even the answer to a single query requires the transitive closure (i.e., the results of all possible queries), which provides no room for tradeoff between preprocessing and query time. Our main contributions are algorithms that significantly improve the worst-case running time of the traditional approach, and provide various tradeoffs depending on the number of queries. For example, in a concurrent system of two components, the traditional approach requires hexic time in the worst case for answering one query as well as computing the transitive closure, whereas we show that with one-time preprocessing in almost cubic time, each subsequent query can be answered in at most linear time, and even the transitive closure can be computed in almost quartic time. Furthermore, we establish conditional optimality results showing that the worst-case running time of our algorithms cannot be improved without achieving major breakthroughs in graph algorithms (i.e., improving the worst-case bound for the shortest path problem in general graphs). Preliminary experimental results show that our algorithms perform favorably on several benchmarks.},
  author       = {Chatterjee, Krishnendu and Goharshady, Amir and Ibsen-Jensen, Rasmus and Pavlogiannis, Andreas},
  location     = {St. Petersburg, FL, USA},
  pages        = {733 -- 747},
  publisher    = {ACM},
  title        = {{Algorithms for algebraic path properties in concurrent systems of constant treewidth components}},
  doi          = {10.1145/2837614.2837624},
  volume       = {20-22},
  year         = {2016},
}

@inproceedings{1386,
  abstract     = {We consider nondeterministic probabilistic programs with the most basic liveness property of termination. We present efficient methods for termination analysis of nondeterministic probabilistic programs with polynomial guards and assignments. Our approach is through synthesis of polynomial ranking supermartingales, that on one hand significantly generalizes linear ranking supermartingales and on the other hand is a counterpart of polynomial ranking-functions for proving termination of nonprobabilistic programs. The approach synthesizes polynomial ranking-supermartingales through Positivstellensatz's, yielding an efficient method which is not only sound, but also semi-complete over a large subclass of programs. We show experimental results to demonstrate that our approach can handle several classical programs with complex polynomial guards and assignments, and can synthesize efficient quadratic ranking-supermartingales when a linear one does not exist even for simple affine programs.},
  author       = {Chatterjee, Krishnendu and Fu, Hongfei and Goharshady, Amir},
  location     = {Toronto, Canada},
  pages        = {3 -- 22},
  publisher    = {Springer},
  title        = {{Termination analysis of probabilistic programs through Positivstellensatz's}},
  doi          = {10.1007/978-3-319-41528-4_1},
  volume       = {9779},
  year         = {2016},
}

@article{1106,
  abstract     = {Circumferential skin creases Kunze type (CSC-KT) is a specific congenital entity with an unknown genetic cause. The disease phenotype comprises characteristic circumferential skin creases accompanied by intellectual disability, a cleft palate, short stature, and dysmorphic features. Here, we report that mutations in either MAPRE2 or TUBB underlie the genetic origin of this syndrome. MAPRE2 encodes a member of the microtubule end-binding family of proteins that bind to the guanosine triphosphate cap at growing microtubule plus ends, and TUBB encodes a β-tubulin isotype that is expressed abundantly in the developing brain. Functional analyses of the TUBB mutants show multiple defects in the chaperone-dependent tubulin heterodimer folding and assembly pathway that leads to a compromised yield of native heterodimers. The TUBB mutations also have an impact on microtubule dynamics. For MAPRE2, we show that the mutations result in enhanced MAPRE2 binding to microtubules, implying an increased dwell time at microtubule plus ends. Further, in vivo analysis of MAPRE2 mutations in a zebrafish model of craniofacial development shows that the variants most likely perturb the patterning of branchial arches, either through excessive activity (under a recessive paradigm) or through haploinsufficiency (dominant de novo paradigm). Taken together, our data add CSC-KT to the growing list of tubulinopathies and highlight how multiple inheritance paradigms can affect dosage-sensitive biological systems so as to result in the same clinical defect.},
  author       = {Isrie, Mala and Breuss, Martin and Tian, Guoling and Hansen, Andi H and Cristofoli, Francesca and Morandell, Jasmin and Kupchinsky, Zachari A and Sifrim, Alejandro and Rodriguez Rodriguez, Celia and Dapena, Elena P and Doonanco, Kurston and Leonard, Norma and Tinsa, Faten and Moortgat, Stéphanie and Ulucan, Hakan and Koparir, Erkan and Karaca, Ender and Katsanis, Nicholas and Marton, Valeria and Vermeesch, Joris R and Davis, Erica E and Cowan, Nicholas J and Keays, David and Van Esch, Hilde},
  journal      = {The American Journal of Human Genetics},
  number       = {6},
  pages        = {790 -- 800},
  publisher    = {Cell Press},
  title        = {{Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type}},
  doi          = {10.1016/j.ajhg.2015.10.014},
  volume       = {97},
  year         = {2015},
}

@article{11073,
  abstract     = {Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.},
  author       = {Hatch, Emily M. and HETZER, Martin W},
  issn         = {0092-8674},
  journal      = {Cell},
  keywords     = {General Biochemistry, Genetics and Molecular Biology},
  number       = {7},
  pages        = {1502--1504},
  publisher    = {Elsevier},
  title        = {{Linking micronuclei to chromosome fragmentation}},
  doi          = {10.1016/j.cell.2015.06.005},
  volume       = {161},
  year         = {2015},
}

@article{11074,
  author       = {Hatch, Emily M. and HETZER, Martin W},
  issn         = {0960-9822},
  journal      = {Current Biology},
  keywords     = {General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology},
  number       = {10},
  pages        = {PR397--R399},
  publisher    = {Elsevier},
  title        = {{Chromothripsis}},
  doi          = {10.1016/j.cub.2015.02.033},
  volume       = {25},
  year         = {2015},
}

@article{11075,
  abstract     = {Previously, we identified the nucleoporin gp210/Nup210 as a critical regulator of muscle and neuronal differentiation, but how this nucleoporin exerts its function and whether it modulates nuclear pore complex (NPC) activity remain unknown. Here, we show that gp210/Nup210 mediates muscle cell differentiation in vitro via its conserved N-terminal domain that extends into the perinuclear space. Removal of the C-terminal domain, which partially mislocalizes gp210/Nup210 away from NPCs, efficiently rescues the differentiation defect caused by the knockdown of endogenous gp210/Nup210. Unexpectedly, a gp210/Nup210 mutant lacking the NPC-targeting transmembrane and C-terminal domains is sufficient for C2C12 myoblast differentiation. We demonstrate that the endoplasmic reticulum (ER) stress-specific caspase cascade is exacerbated during Nup210 depletion and that blocking ER stress-mediated apoptosis rescues differentiation of Nup210-deficient cells. Our results suggest that the role of gp210/Nup210 in cell differentiation is mediated by its large luminal domain, which can act independently of NPC association and appears to play a pivotal role in the maintenance of nuclear envelope/ER homeostasis.},
  author       = {Gomez-Cavazos, J. Sebastian and HETZER, Martin W},
  issn         = {1540-8140},
  journal      = {Journal of Cell Biology},
  keywords     = {Cell Biology},
  number       = {6},
  pages        = {671--681},
  publisher    = {Rockefeller University Press},
  title        = {{The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis}},
  doi          = {10.1083/jcb.201410047},
  volume       = {208},
  year         = {2015},
}

@article{11076,
  abstract     = {Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation.},
  author       = {Ibarra, Arkaitz and HETZER, Martin W},
  issn         = {1549-5477},
  journal      = {Genes & Development},
  keywords     = {Developmental Biology, Genetics},
  number       = {4},
  pages        = {337--349},
  publisher    = {Cold Spring Harbor Laboratory},
  title        = {{Nuclear pore proteins and the control of genome functions}},
  doi          = {10.1101/gad.256495.114},
  volume       = {29},
  year         = {2015},
}

@article{11077,
  abstract     = {Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channels that mediate nuclear transport across the nuclear envelope. Recent evidence suggests that several Nups have additional roles in controlling the activation and silencing of developmental genes; however, the mechanistic details of these functions remain poorly understood. Here, we show that depletion of Nup153 in mouse embryonic stem cells (mESCs) causes the derepression of developmental genes and induction of early differentiation. This loss of stem cell identity is not associated with defects in the nuclear import of key pluripotency factors. Rather, Nup153 binds around the transcriptional start site (TSS) of developmental genes and mediates the recruitment of the polycomb-repressive complex 1 (PRC1) to a subset of its target loci. Our results demonstrate a chromatin-associated role of Nup153 in maintaining stem cell pluripotency by functioning in mammalian epigenetic gene silencing.},
  author       = {Jacinto, Filipe V. and Benner, Chris and HETZER, Martin W},
  issn         = {1549-5477},
  journal      = {Genes & Development},
  keywords     = {Developmental Biology, Genetics},
  number       = {12},
  pages        = {1224--1238},
  publisher    = {Cold Spring Harbor Laboratory},
  title        = {{The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing}},
  doi          = {10.1101/gad.260919.115},
  volume       = {29},
  year         = {2015},
}

@article{11078,
  abstract     = {Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old animals. The majority are a consequence of altered translation output, that is, the combined effect of changes in transcript abundance and translation efficiency. In addition, we identify 130 proteins whose overall abundance remains unchanged but whose sub-cellular localization, phosphorylation state, or splice-form varies. While some protein-level differences appear to be a generic property of the rats’ chronological age, the majority are specific to one organ. These may be a consequence of the organ’s physiology or the chronological age of the cells within the tissue. Taken together, our study provides an initial view of the proteome at the molecular, sub-cellular, and organ level in young and old rats.},
  author       = {Ori, Alessandro and Toyama, Brandon H. and Harris, Michael S. and Bock, Thomas and Iskar, Murat and Bork, Peer and Ingolia, Nicholas T. and HETZER, Martin W and Beck, Martin},
  issn         = {2405-4712},
  journal      = {Cell Systems},
  keywords     = {Cell Biology, Histology, Pathology and Forensic Medicine},
  number       = {3},
  pages        = {P224--237},
  publisher    = {Elsevier},
  title        = {{Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats}},
  doi          = {10.1016/j.cels.2015.08.012},
  volume       = {1},
  year         = {2015},
}

@article{11079,
  abstract     = {Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad range of ages, either by iPSC-based reprogramming and differentiation or by direct conversion into induced neurons (iNs). While iPSCs and derived neurons did not retain aging-associated gene signatures, iNs displayed age-specific transcriptional profiles and revealed age-associated decreases in the nuclear transport receptor RanBP17. We detected an age-dependent loss of nucleocytoplasmic compartmentalization (NCC) in donor fibroblasts and corresponding iNs and found that reduced RanBP17 impaired NCC in young cells, while iPSC rejuvenation restored NCC in aged cells. These results show that iNs retain important aging-related signatures, thus allowing modeling of the aging process in vitro, and they identify impaired NCC as an important factor in human aging.},
  author       = {Mertens, Jerome and Paquola, Apuã C.M. and Ku, Manching and Hatch, Emily and Böhnke, Lena and Ladjevardi, Shauheen and McGrath, Sean and Campbell, Benjamin and Lee, Hyungjun and Herdy, Joseph R. and Gonçalves, J. Tiago and Toda, Tomohisa and Kim, Yongsung and Winkler, Jürgen and Yao, Jun and HETZER, Martin W and Gage, Fred H.},
  issn         = {1934-5909},
  journal      = {Cell Stem Cell},
  keywords     = {Cell Biology, Genetics, Molecular Medicine},
  number       = {6},
  pages        = {705--718},
  publisher    = {Elsevier},
  title        = {{Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects}},
  doi          = {10.1016/j.stem.2015.09.001},
  volume       = {17},
  year         = {2015},
}

@article{11519,
  abstract     = {Faint Lyα emitters become increasingly rarer toward the reionization epoch (z ∼ 6–7). However, observations from a very large (∼5 deg2) Lyα narrow-band survey at z = 6.6 show that this is not the case for the most luminous emitters, capable of ionizing their own local bubbles. Here we present follow-up observations of the two most luminous Lyα candidates in the COSMOS field: “MASOSA” and “CR7.” We used X-SHOOTER, SINFONI, and FORS2 on the Very Large Telescope, and DEIMOS on Keck, to confirm both candidates beyond any doubt. We find redshifts of z = 6.541 and z = 6.604 for “MASOSA” and “CR7,” respectively. MASOSA has a strong detection in Lyα with a line width of 386 ± 30 km s−1 (FWHM) and with very high EW0 (>200 Å), but undetected in the continuum, implying very low stellar mass and a likely young, metal-poor stellar population. “CR7,” with an observed Lyα luminosity of 1043.92±0.05 erg s−1 is the most luminous Lyα emitter ever found at z > 6 and is spatially extended (∼16 kpc). “CR7” reveals a narrow Lyα line with 266 ± 15 km s−1 FWHM, being detected in the near-infrared (NIR) (rest-frame UV; β = −2.3 ± 0.1) and in IRAC/Spitzer. We detect a narrow He II 1640 Å emission line (6σ, FWHM = 130 ± 30 km s−1 ) in CR7 which can explain the clear excess seen in the J-band photometry (EW0 ∼ 80 Å). We find no other emission lines from the UV to the NIR in our X-SHOOTER spectra (He II/O III] 1663 Å > 3 and He II/C III] 1908 Å > 2.5). We conclude that CR7 is best explained by a combination of a PopIII-like population, which dominates the rest-frame UV and the nebular emission, and a more normal stellar population, which presumably dominates the mass. Hubble Space Telescope/WFC3 observations show that the light is indeed spatially separated between a very blue component, coincident with Lyα and He II emission, and two red components (∼5 kpc away), which dominate the mass. Our findings are consistent with theoretical predictions of a PopIII wave, with PopIII star formation migrating away from the original sites of star formation.},
  author       = {Sobral, David and Matthee, Jorryt J and Darvish, Behnam and Schaerer, Daniel and Mobasher, Bahram and Röttgering, Huub and Santos, Sérgio and Hemmati, Shoubaneh},
  issn         = {1538-4357},
  journal      = {The Astrophysical Journal},
  keywords     = {Space and Planetary Science, Astronomy and Astrophysics, dark ages, reionization, first stars – early universe – galaxies: evolution},
  number       = {2},
  pages        = {139},
  publisher    = {IOP Publishing},
  title        = {{Evidence for PopIII-like stellar populations in the most luminous Lyα emitters at the epoch of reionisation: Spectroscopic confirmation}},
  doi          = {10.1088/0004-637X/808/2/139},
  volume       = {808},
  year         = {2015},
}

@article{11579,
  abstract     = {CR7 is the brightest z = 6.6 Ly α emitter (LAE) known to date, and spectroscopic follow-up by Sobral et al. suggests that CR7 might host Population (Pop) III stars. We examine this interpretation using cosmological hydrodynamical simulations. Several simulated galaxies show the same ‘Pop III wave’ pattern observed in CR7. However, to reproduce the extreme CR7 Ly α/He II1640 line luminosities (⁠Lα/HeII⁠) a top-heavy initial mass function and a massive ( ≳ 107 M⊙) Pop III burst with age ≲ 2 Myr are required. Assuming that the observed properties of Ly α and He II emission are typical for Pop III, we predict that in the COSMOS/UDS/SA22 fields, 14 out of the 30 LAEs at z = 6.6 with Lα > 1043.3 erg s−1 should also host Pop III stars producing an observable LHeII≳1042.7ergs−1⁠. As an alternate explanation, we explore the possibility that CR7 is instead powered by accretion on to a direct collapse black hole. Our model predicts Lα, LHeII⁠, and X-ray luminosities that are in agreement with the observations. In any case, the observed properties of CR7 indicate that this galaxy is most likely powered by sources formed from pristine gas. We propose that further X-ray observations can distinguish between the two above scenarios.},
  author       = {Pallottini, A. and Ferrara, A. and Pacucci, F. and Gallerani, S. and Salvadori, S. and Schneider, R. and Schaerer, D. and Sobral, D. and Matthee, Jorryt J},
  issn         = {1365-2966},
  journal      = {Monthly Notices of the Royal Astronomical Society},
  keywords     = {Space and Planetary Science, Astronomy and Astrophysics, black hole physics, stars: Population III, galaxies: high-redshift},
  number       = {3},
  pages        = {2465--2470},
  publisher    = {Oxford University Press},
  title        = {{The brightest Lyα emitter: Pop III or black hole?}},
  doi          = {10.1093/mnras/stv1795},
  volume       = {453},
  year         = {2015},
}

@article{11580,
  abstract     = {We present results from the largest contiguous narrow-band survey in the near-infrared. We have used the wide-field infrared camera/Canada–France–Hawaii Telescope and the lowOH2 filter (1.187 ± 0.005 μm) to survey ≈10 deg2 of contiguous extragalactic sky in the SA22 field. A total of ∼6000 candidate emission-line galaxies are found. We use deep ugrizJK data to obtain robust photometric redshifts. We combine our data with the High-redshift(Z) Emission Line Survey (HiZELS), explore spectroscopic surveys (VVDS, VIPERS) and obtain our own spectroscopic follow-up with KMOS, FMOS and MOSFIRE to derive large samples of high-redshift emission-line selected galaxies: 3471 Hα emitters at z = 0.8, 1343 [O III] + Hβ emitters at z = 1.4 and 572 [O II] emitters at z = 2.2. We probe comoving volumes of >106 Mpc3 and find significant overdensities, including an 8.5σ (spectroscopically confirmed) overdensity of Hα emitters at z = 0.81. We derive Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4, 2.2, respectively, and present implications for future surveys such as Euclid. Our uniquely large volumes/areas allow us to subdivide the samples in thousands of randomized combinations of areas and provide a robust empirical measurement of sample/cosmic variance. We show that surveys for star-forming/emission-line galaxies at a depth similar to ours can only overcome cosmic-variance (errors <10 per cent) if they are based on volumes >5 × 105 Mpc3; errors on L* and ϕ* due to sample (cosmic) variance on surveys probing ∼104 and ∼105 Mpc3 are typically very high: ∼300 and ∼40–60 per cent, respectively.},
  author       = {Sobral, D. and Matthee, Jorryt J and Best, P. N. and Smail, I. and Khostovan, A. A. and Milvang-Jensen, B. and Kim, J.-W. and Stott, J. and Calhau, J. and Nayyeri, H. and Mobasher, B.},
  issn         = {1365-2966},
  journal      = {Monthly Notices of the Royal Astronomical Society},
  keywords     = {Space and Planetary Science, Astronomy and Astrophysics, galaxies: evolution, galaxies: formation, galaxies: luminosity function, mass function, cosmology: observations, early Universe, large-scale structure of Universe},
  number       = {3},
  pages        = {2303--2323},
  publisher    = {Oxford University Press},
  title        = {{CF-HiZELS, an ∼10 deg2 emission-line survey with spectroscopic follow-up: Hα, [O III] + Hβ and [O II] luminosity functions at z = 0.8, 1.4 and 2.2 }},
  doi          = {10.1093/mnras/stv1076},
  volume       = {451},
  year         = {2015},
}

@article{11581,
  abstract     = {Using wide-field narrow-band surveys, we provide a new measurement of the z = 6.6 Lymanα emitter (LAE) luminosity function (LF), which constraints the bright end for the first time. We use a combination of archival narrow-band NB921 data in UDS and new NB921 measurements in SA22 and COSMOS/UltraVISTA, all observed with the Subaru telescope, with a total area of ∼5 deg2. We exclude lower redshift interlopers by using broad-band optical and near-infrared photometry and also exclude three supernovae with data split over multiple epochs. Combining the UDS and COSMOS samples, we find no evolution of the bright end of the Lyα LF between z = 5.7 and 6.6, which is supported by spectroscopic follow-up, and conclude that sources with Himiko-like luminosity are not as rare as previously thought, with number densities of ∼1.5 × 10−5 Mpc−3. Combined with our wide-field SA22 measurements, our results indicate a non-Schechter-like bright end of the LF at z = 6.6 and a different evolution of observed faint and bright LAEs, overcoming cosmic variance. This differential evolution is also seen in the spectroscopic follow-up of UV-selected galaxies and is now also confirmed for LAEs, and we argue that it may be an effect of reionization. Using a toy model, we show that such differential evolution of the LF is expected, since brighter sources are able to ionize their surroundings earlier, such that Lyα photons are able to escape. Our targets are excellent candidates for detailed follow-up studies and provide the possibility to give a unique view on the earliest stages in the formation of galaxies and reionization process.},
  author       = {Matthee, Jorryt J and Sobral, David and Santos, Sérgio and Röttgering, Huub and Darvish, Behnam and Mobasher, Bahram},
  issn         = {1365-2966},
  journal      = {Monthly Notices of the Royal Astronomical Society},
  keywords     = {Space and Planetary Science, Astronomy and Astrophysics},
  number       = {1},
  pages        = {400--417},
  publisher    = {Oxford University Press},
  title        = {{Identification of the brightest Lyα emitters at z = 6.6: implications for the evolution of the luminosity function in the reionization era}},
  doi          = {10.1093/mnras/stv947},
  volume       = {451},
  year         = {2015},
}

@article{11668,
  abstract     = {We study multiple keyword sponsored search auctions with budgets. Each keyword has multiple ad slots with a click-through rate. The bidders have additive valuations, which are linear in the click-through rates, and budgets, which are restricting their overall payments. Additionally, the number of slots per keyword assigned to a bidder is bounded.

We show the following results: (1) We give the first mechanism for multiple keywords, where click-through rates differ among slots. Our mechanism is incentive compatible in expectation, individually rational in expectation, and Pareto optimal. (2) We study the combinatorial setting, where each bidder is only interested in a subset of the keywords. We give an incentive compatible, individually rational, Pareto-optimal, and deterministic mechanism for identical click-through rates. (3) We give an impossibility result for incentive compatible, individually rational, Pareto-optimal, and deterministic mechanisms for bidders with diminishing marginal valuations.},
  author       = {Colini-Baldeschi, Riccardo and Leonardi, Stefano and Henzinger, Monika H and Starnberger, Martin},
  issn         = {2167-8383},
  journal      = {ACM Transactions on Economics and Computation},
  keywords     = {Algorithms, Economics, Clinching ascending auction, auctions with budgets, Sponsored search auctions},
  number       = {1},
  publisher    = {Association for Computing Machinery},
  title        = {{On multiple keyword sponsored search auctions with budgets}},
  doi          = {10.1145/2818357},
  volume       = {4},
  year         = {2015},
}

@article{11669,
  abstract     = {We study individual rational, Pareto-optimal, and incentive compatible mechanisms for auctions with heterogeneous items and budget limits. We consider settings with multiunit demand and additive valuations. For single-dimensional valuations we prove a positive result for randomized mechanisms, and a negative result for deterministic mechanisms. While the positive result allows for private budgets, the negative result is for public budgets. For multidimensional valuations and public budgets we prove an impossibility result that applies to deterministic and randomized mechanisms. Taken together this shows the power of randomization in certain settings with heterogeneous items, but it also shows its limitations.},
  author       = {Dütting, Paul and Henzinger, Monika H and Starnberger, Martin},
  issn         = {2167-8383},
  journal      = {ACM Transactions on Economics and Computation},
  keywords     = {Algorithmic game theory, auction theory, Clinching auction, Pareto optimality, Budget limits},
  number       = {1},
  publisher    = {Association for Computing Machinery},
  title        = {{Auctions for heterogeneous items and budget limits}},
  doi          = {10.1145/2818351},
  volume       = {4},
  year         = {2015},
}