@article{3261, abstract = {Cells in a developing embryo have no direct way of "measuring" their physical position. Through a variety of processes, however, the expression levels of multiple genes come to be correlated with position, and these expression levels thus form a code for "positional information." We show how to measure this information, in bits, using the gap genes in the Drosophila embryo as an example. Individual genes carry nearly two bits of information, twice as much as expected if the expression patterns consisted only of on/off domains separated by sharp boundaries. Taken together, four gap genes carry enough information to define a cell's location with an error bar of ~1% along the anterior-posterior axis of the embryo. This precision is nearly enough for each cell to have a unique identity, which is the maximum information the system can use, and is nearly constant along the length of the embryo. We argue that this constancy is a signature of optimality in the transmission of information from primary morphogen inputs to the output of the gap gene network.}, author = {Dubuis, Julien and Tkacik, Gasper and Wieschaus, Eric and Gregor, Thomas and Bialek, William}, journal = {PNAS}, number = {41}, pages = {16301 -- 16308}, publisher = {National Academy of Sciences}, title = {{Positional information, in bits}}, doi = {10.1073/pnas.1315642110}, volume = {110}, year = {2013}, } @article{331, abstract = {We report a procedure to prepare highly monodisperse copper telluride nanocubes, nanoplates, and nanorods. The procedure is based on the reaction of a copper salt with trioctylphosphine telluride in the presence of lithium bis(trimethylsilyl)amide and oleylamine. CuTe nanocrystals display a strong near-infrared optical absorption associated with localized surface plasmon resonances. We exploit this plasmon resonance for the design of surface-enhanced Raman scattering sensors for unconventional optical probes. Furthermore, we also report here our preliminary analysis of the use of CuTe nanocrystals as cytotoxic and photothermal agents.}, author = {Li, Wenhua and Zamani, Reza and Rivera Gil, Pilar and Pelaz, Beatriz and Ibáñez, Maria and Cadavid, Doris and Shavel, Alexey and Alvarez Puebla, Ramon and Parak, Wolfgang and Arbiol, Jordi and Cabot, Andreu}, journal = {Journal of the American Chemical Society}, number = {19}, pages = {7098 -- 7101}, publisher = {ACS}, title = {{CuTe nanocrystals: Shape and size control, plasmonic properties, and use as SERS probes and photothermal agents}}, doi = {10.1021/ja401428e}, volume = {135}, year = {2013}, } @misc{3321, author = {Quadrianto, Novi and Lampert, Christoph}, booktitle = {Encyclopedia of Systems Biology}, editor = {Dubitzky, Werner and Wolkenhauer, Olaf and Cho, Kwang and Yokota, Hiroki}, pages = {1069 -- 1069}, publisher = {Springer}, title = {{Kernel based learning}}, doi = {10.1007/978-1-4419-9863-7_604}, volume = {3}, year = {2013}, } @article{342, abstract = {Morphology is a key parameter in the design of novel nanocrystals and nanomaterials with controlled functional properties. Here, we demonstrate the potential of foreign metal ions to tune the morphology of colloidal semiconductor nanoparticles. We illustrate the underlying mechanism by preparing copper selenide nanocubes in the presence of Al ions. We further characterize the plasmonic properties of the obtained nanocrystals and demonstrate their potential as a platform to produce cubic nanoparticles with different composition by cation exchange. © 2013 American Chemical Society.}, author = {Li, Wenhua and Zamani, Reza and Ibáñez, Maria and Cadavid, Doris and Shavel, Alexey and Morante, Joan and Arbiol, Jordi and Cabot, Andreu}, journal = {Journal of the American Chemical Society}, number = {12}, pages = {4664 -- 4667}, publisher = {American Chemical Society}, title = {{Metal ions to control the morphology of semiconductor nanoparticles: Copper selenide nanocubes}}, doi = {10.1021/ja400472m}, volume = {135}, year = {2013}, } @article{343, abstract = {The bottom-up assembly of nanocrystals provides access to a three-dimensional composition control at the nanoscale not attainable by any other technology. In particular, colloidal nanoheterostructures, with intrinsic multiphase organization, are especially appealing building blocks for the bottom-up production of nanocomposites. In the present work, we use PbTe-PbS as the model material system and thermoelectricity as the paradigmatic application to investigate the potential of the bottom-up assembly of core-shell nanoparticles to produce functional nanocomposites. With this goal in mind, a rapid, high-yield and scalable colloidal synthetic route to prepare grams of PbTe@PbS core-shell nanoparticles with unprecedented narrow size distributions and exceptional composition control is detailed. PbTe@PbS nanoparticles were used as building blocks for the bottom-up production of PbTe-PbS nanocomposites with tuned composition. In such PbTe-PbS nanocomposites, synergistic nanocrystal doping effects result in up to 10-fold higher electrical conductivities than in pure PbTe and PbS nanomaterials. At the same time, the acoustic impedance mismatch between PbTe and PbS phases and a partial phase alloying provide PbTe-PbS nanocomposites with strongly reduced thermal conductivities. As a result, record thermoelectric figures of merit (ZT) of ∼1.1 were obtained from undoped PbTe and PbS phases at 710 K. These high ZT values prove the potential of the proposed processes to produce efficient functional nanomaterials with programmable properties. © 2013 American Chemical Society.}, author = {Ibáñez, Maria and Zamani, Reza and Gorsse, Stéphane and Fan, Jiandong and Ortega, Silvia and Cadavid, Doris and Morante, Joan and Arbiol, Jordi and Cabot, Andreu}, journal = {ACS Nano}, number = {3}, pages = {2573 -- 2586}, publisher = {American Chemical Society}, title = {{Core shell nanoparticles as building blocks for the bottom-up production of functional nanocomposites: PbTe PbS thermoelectric properties}}, doi = {10.1021/nn305971v}, volume = {7}, year = {2013}, } @article{344, abstract = {Copper-based selenides are attracting increasing interest due to their outstanding optoelectronic and thermoelectric properties. Herein a novel colloidal synthetic route to prepare Cu2SnSe3 nanocrystals with controlled size, shape and composition is presented. The high yield of the developed procedure allowed its up-scaling to the production of grams of colloidal Cu2SnSe3 nanocrystals. These nanocrystals were used as building blocks for the production of Cu2SnSe3 bulk nanostructured materials by spark plasma sintering. The thermoelectric properties of the prepared nanocrystalline Cu2SnSe3 pellets were characterized in the temperature range from 300 to 720 K. The obtained results show the bottom-up production of nanocrystalline materials from solution-processed nanocrystals to be a potentially advantageous alternative to conventional methods of production of efficient thermoelectric materials.}, author = {Ibáñez, Maria and Cadavid, Doris and Anselmi Tamburini, Umberto and Zamani, Reza and Gorsse, Stéphane and Li, Wenhua and López, Antonio and Morante, Joan and Arbiol, Jordi and Cabot, Andreu}, journal = {Journal of Materials Chemistry A}, number = {4}, pages = {1421 -- 1426}, publisher = {Royal Society of Chemistry}, title = {{Colloidal synthesis and thermoelectric properties of Cu 2SnSe3 nanocrystals}}, doi = {10.1039/C2TA00419D}, volume = {1}, year = {2013}, } @article{351, abstract = {A multistrategy approach to overcome the main challenges of nanoparticle-based solution-processed Cu2ZnSnSe4 thin film solar cells is presented. We developed an efficient ligand exchange strategy, using an antimony salt, to displace organic ligands from the surface of Cu 2ZnSnS4 nanoparticles. An automated pulsed spray-deposition system was used to deposit the nanoparticles into homogeneous and crack-free films with controlled thickness. After annealing the film in a Se-rich atmosphere, carbon-free and crystalline Cu2ZnSnSe4 absorber layers were obtained. Not only was crystallization promoted by the complete removal of organics, but also Sb itself played a critical role. The Sb-assisted crystal growth is associated with the formation of a Sb-based compound at the grain boundaries, which locally reduces the melting point, thus promoting the film diffusion-limited crystallization. }, author = {Carrete, Alex and Shavel, Alexey and Fontané, Xavier and Montserrat, Joana and Fan, Jiandong and Ibáñez, Maria and Saucedo, Edgardo and Pérez Rodríguez, Alejandro and Cabot, Andreu}, journal = {Journal of the American Chemical Society}, number = {43}, pages = {15982 -- 15985}, publisher = {American Chemical Society}, title = {{Antimony-based ligand exchange to promote crystallization in spray-deposited Cu2ZnSnSe4 solar cells}}, doi = {10.1021/ja4068639}, volume = {135}, year = {2013}, } @article{352, abstract = {The presence of organic ligands on the surface of colloidal nanoparticles strongly limits their performance in technological applications where charge carrier transfer/transport plays an important role. We use metal salts, matched with the nanoparticle composition, to eliminate the surface organic ligands without introducing extrinsic impurities in the final nanomaterial. The potential of the simple, general and scalable processes presented here is demonstrated by characterizing the thermoelectric properties of nanostructured Ag2Te produced by the bottom up assembly of Ag2Te nanocrystals. A 6-fold increase of the thermoelectric figure of merit of Ag2Te was obtained when organic ligands were displaced by AgNO3. The same procedure can enhance the performance of nanocrystals and nanocrystal-based devices in a broad range of applications, from photovoltaics and thermoelectrics to catalysis.}, author = {Cadavid, Doris and Ibáñez, Maria and Shavel, Alexey and Durá, Oscar and López De La Torre, Marco and Cabot, Andreu}, journal = {Journal of Materials Chemistry A}, number = {15}, pages = {4864 -- 4870}, publisher = {Royal Society of Chemistry}, title = {{Organic ligand displacement by metal salts to enhance nanoparticle functionality: Thermoelectric properties of Ag inf 2 inf Te}}, doi = {10.1039/C3TA01455J}, volume = {1}, year = {2013}, } @article{376, abstract = {The compositional versatility of I2–II–IV–VI4 tetrahedrally-coordinated compounds allows for accommodating their functional properties to numerous technological applications. Among them, Cu2ZnSnSe4 is an emerging photovoltaic material and Cu2CdSnSe4 displays excellent thermoelectric properties. The third compound of this family, Cu2HgSnSe4, remains relatively unexplored. Herein, a synthetic route to produce Cu2HgSnSe4 nanoparticles with narrow size distribution and controlled composition is presented. Cu2HgSnSe4 nanoparticles were subsequently used as building blocks to produce bulk nanocrystalline materials, whose thermoelectric properties were analyzed. A very preliminary adjustment of the material composition yielded Seebeck coefficients up to 160 μV K−1, electrical conductivities close to 104 S m−1 and thermal conductivities down to 0.5 W m−1 K−1.}, author = {Li, Wenhua and Ibáñez, Maria and Zamani, Reza and García Castelló, Nuria and Stéphane, Grosse and Cadavid, Doris and Prades, Joan and Arbiol, Jordi and Cabot, Andreu}, journal = {CrystEngComm}, pages = {8966 -- 8971}, publisher = {Royal Society of Chemistry}, title = {{Cu2HgSnSe4 nanoparticles: synthesis and thermoelectric properties}}, doi = {10.1039/C3CE41583J}, volume = {44}, year = {2013}, } @article{378, abstract = {Until recently, to prepare nanocrystals of a new material, scientists searched their shelves for the appropriate molecular precursors, surfactants, and solvents. They then optimized the reaction conditions for the atoms to self-assemble into monodisperse nanocrystals (1). This approach is being replaced by a simpler strategy, in which preformed nanocrystals serve as templates to produce nanoparticles with a different composition through chemical transformation. On page 964 of this issue, Oh et al. (2) report a powerful mechanism that allows the composition of oxide nanoparticles to be transformed in solution and at low temperatures.}, author = {Ibáñez, Maria and Cabot, Andreu}, journal = {Science}, number = {6135}, pages = {935 -- 936}, publisher = {American Association for the Advancement of Science}, title = {{All change for nanocrystals}}, doi = {10.1126/science.1239221}, volume = {340}, year = {2013}, } @article{1726, abstract = {The development of a functional tissue requires coordination of the amplification of progenitors and their differentiation into specific cell types. The molecular basis for this coordination during myotome ontogeny is not well understood. Dermomytome progenitors that colonize the myotome first acquire myocyte identity and subsequently proliferate as Pax7-expressing progenitors before undergoing terminal differentiation. We show that the dynamics of sonic hedgehog (Shh) signaling is crucial for this transition in both avian and mouse embryos. Initially, Shh ligand emanating from notochord/floor plate reaches the dermomyotome, where it both maintains the proliferation of dermomyotome cells and promotes myogenic differentiation of progenitors that colonized the myotome. Interfering with Shh signaling at this stage produces small myotomes and accumulation of Pax7-expressing progenitors. An in vivo reporter of Shh activity combined with mouse genetics revealed the existence of both activator and repressor Shh activities operating on distinct subsets of cells during the epaxial myotomal maturation. In contrast to observations in mice, in avians Shh promotes the differentiation of both epaxial and hypaxial myotome domains. Subsequently, myogenic progenitors become refractory to Shh; this is likely to occur at the level of, or upstream of, smoothened signaling. The end of responsiveness to Shh coincides with, and is thus likely to enable, the transition into the growth phase of the myotome.}, author = {Kahane, Nitza and Ribes, Vanessa and Anna Kicheva and Briscoe, James and Kalcheim, Chaya}, journal = {Development}, number = {8}, pages = {1740 -- 1750}, publisher = {Company of Biologists}, title = {{The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling}}, doi = {10.1242/dev.092726}, volume = {140}, year = {2013}, } @article{1727, abstract = {Cells at different positions in a developing tissue receive different concentrations of signaling molecules, called morphogens, and this influences their cell fate. Morphogen concentration gradients have been proposed to control patterning as well as growth in many developing tissues. Some outstanding questions about tissue patterning by morphogen gradients are the following: What are the mechanisms that regulate gradient formation and shape? Is the positional information encoded in the gradient sufficiently precise to determine the positions of target gene domain boundaries? What are the temporal dynamics of gradients and how do they relate to patterning and growth? These questions are inherently quantitative in nature and addressing them requires measuring morphogen concentrations in cells, levels of downstream signaling activity, and kinetics of morphogen transport. Here we first present methods for quantifying morphogen gradient shape in which the measurements can be calibrated to reflect actual morphogen concentrations. We then discuss using fluorescence recovery after photobleaching to study the kinetics of morphogen transport at the tissue level. Finally, we present particle tracking as a method to study morphogen intracellular trafficking.}, author = {Anna Kicheva and Holtzer, Laurent and Wartlick, Ortrud and Schmidt, Thomas S and González-Gaitán, Marcos A}, journal = {Cold Spring Harbor Protocols}, number = {5}, pages = {387 -- 403}, publisher = {Cold Spring Harbor Laboratory Press}, title = {{Quantitative imaging of morphogen gradients in drosophila imaginal discs}}, doi = {10.1101/pdb.top074237}, volume = {8}, year = {2013}, } @article{1759, abstract = {We report an electric-field-induced giant modulation of the hole g factor in SiGe nanocrystals. The observed effect is ascribed to a so-far overlooked contribution to the g factor that stems from the mixing between heavy- and light-hole wave functions. We show that the relative displacement between the confined heavy- and light-hole states, occurring upon application of the electric field, alters their mixing strength leading to a strong nonmonotonic modulation of the g factor.}, author = {Ares, Natalia and Golovach, Vitaly N and Georgios Katsaros and Stoffel, Mathieu and Fournel, Frank and Glazman, Leonid I and Schmidt, Oliver G and De Franceschi, Silvano}, journal = {Physical Review Letters}, number = {4}, publisher = {American Physical Society}, title = {{Nature of tunable hole g factors in quantum dots}}, doi = {10.1103/PhysRevLett.110.046602}, volume = {110}, year = {2013}, } @article{1760, abstract = {We report on hole g-factor measurements in three terminal SiGe self-assembled quantum dot devices with a top gate electrode positioned very close to the nanostructure. Measurements of both the perpendicular as well as the parallel g-factor reveal significant changes for a small modulation of the top gate voltage. From the observed modulations, we estimate that, for realistic experimental conditions, hole spins can be electrically manipulated with Rabi frequencies in the order of 100 MHz. This work emphasises the potential of hole-based nano-devices for efficient spin manipulation by means of the g-tensor modulation technique.}, author = {Ares, Natalia and Georgios Katsaros and Golovach, Vitaly N and Zhang, Jianjun and Prager, Aaron A and Glazman, Leonid I and Schmidt, Oliver G and De Franceschi, Silvano}, journal = {Applied Physics Letters}, number = {26}, publisher = {American Institute of Physics}, title = {{SiGe quantum dots for fast hole spin Rabi oscillations}}, doi = {10.1063/1.4858959}, volume = {103}, year = {2013}, } @article{17624, abstract = {A near-equal-mass binary black hole (BH) can clear a central cavity in a circumbinary accretion disc; however, previous works have revealed accretion streams entering this cavity. Here we use 2D hydrodynamical simulations to study the accretion streams and their periodic behaviour. In particular, we perform a suite of simulations, covering different binary mass ratios q = M2/M1 in the range 0.003 ≤ q ≤ 1. In each case, we follow the system for several thousand binary orbits, until it relaxes to a stable accretion pattern. We find the following results: (i) the binary is efficient in maintaining a low-density cavity. However, the time-averaged mass accretion rate into the cavity, through narrow coherent accretion streams, is suppressed by at most a factor of a few compared to a disc with a single BH with the same mass; (ii) for q ≳ 0.05, the accretion rate is strongly modulated by the binary, and depending on the precise value of q, the power spectrum of the accretion rate shows either one, two or three distinct periods; and (iii) for q ≲ 0.05, the accretion rate becomes steady, with no time variations. Most binaries produced in galactic mergers are expected to have q ≳ 0.05. If the luminosity of these binaries tracks their accretion rate, then a periodogram of their light curve could help in their identification, and to constrain their mass ratio and disc properties.}, author = {D'Orazio, Daniel J. and Haiman, Zoltán and MacFadyen, Andrew}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {4}, pages = {2997--3020}, publisher = {Oxford University Press}, title = {{Accretion into the central cavity of a circumbinary disc}}, doi = {10.1093/mnras/stt1787}, volume = {436}, year = {2013}, } @article{17631, abstract = {We propose a novel use of high-redshift galaxies, discovered in deep Hubble Space Telescope (HST) fields around strong lensing clusters. These fields probe small comoving volumes (∼103 Mpc3) at high magnification (μ ≳ 10) and can detect otherwise inaccessible ultra-faint galaxies. Even a few galaxies found in such small volumes require a very high number density of collapsed dark matter (DM) haloes. This implies significant primordial power on small scales, allowing these observations to rule out popular alternatives to standard cold dark matter (CDM) models, such as warm dark matter (WDM). In this work, we analytically compute WDM halo mass functions at z = 10, including the effects of both particle free-streaming and residual velocity dispersion. We show that the two z ≈ 10 galaxies already detected by the Cluster Lensing And Supernova survey with Hubble (CLASH) survey are sufficient to constrain the WDM particle mass to mx > 1 (0.9) keV at 68 per cent (95 per cent) confidence limit (for a thermal relic relativistic at decoupling). This limit depends only on the WDM halo mass function and, unlike previous constraints on mx, is independent of any astrophysical modelling. The forthcoming HST Frontier Fields can significantly tighten these constraints.}, author = {Pacucci, Fabio and Mesinger, Andrei and Haiman, Zoltán}, issn = {1745-3933}, journal = {Monthly Notices of the Royal Astronomical Society: Letters}, number = {1}, pages = {L53--L57}, publisher = {Oxford University Press}, title = {{Focusing on warm dark matter with lensed high-redshift galaxies}}, doi = {10.1093/mnrasl/slt093}, volume = {435}, year = {2013}, } @article{17638, abstract = {Pulsar timing arrays (PTAs) may eventually be able to detect not only the stochastic gravitational-wave (GW) background of SMBH binaries, but also individual, particularly massive binaries whose signals stick out above the background. In this contribution, we discuss the possibility of identifying and studying such 'resolved' binaries through their electromagnetic emission. The host galaxies of such binaries are themselves expected to be also very massive and rare, so that out to redshifts z ≈ 0.2 a unique massive galaxy may be identified as the host. At higher redshifts, the PTA error boxes are larger and may contain as many as several hundred massive-galaxy interlopers. In this case, the true counterpart may be identified, if it is accreting gas efficiently, as an active galactic nucleus (AGN) with a peculiar spectrum and variable emission features. Specifically, the binary's tidal torques expel the gas from the inner part of the accretion disc, making it unusually dim in x-ray and UV bands and in broad optical emission lines. The tails of the broad wings of any FeKα emission line may also be 'clipped' and missing. The binary's orbital motion, as well as the gas motions it induces, may trigger quasiperiodic variations. These include coherent flux variability, such as luminous, multi-wavelength flares, as well as Doppler shifts of broad emission lines and 'see-saw' oscillations in the FeKα line. Additional features, such as evidence for a recent major merger or dual collimated jets, could also corroborate the counterpart. These properties would make resolved PTA sources stand out among AGN with similar overall luminosities and allow their identification.}, author = {Tanaka, Takamitsu L and Haiman, Zoltán}, issn = {0264-9381}, journal = {Classical and Quantum Gravity}, number = {22}, publisher = {IOP Publishing}, title = {{Electromagnetic signatures of supermassive black hole binaries resolved by PTAs}}, doi = {10.1088/0264-9381/30/22/224012}, volume = {30}, year = {2013}, } @article{17646, abstract = {Structures in Warm Dark Matter (WDM) models are exponentially suppressed below a certain scale, characterized by the dark matter particle mass, mx. Since structures form hierarchically, the presence of collapsed objects at high-redshifts can set strong lower limits on mx. We place robust constraints on mx using recent results from the {\it Swift} database of high-redshift gamma-ray bursts (GRBs). We parameterize the redshift evolution of the ratio between the cosmic GRB rate and star formation rate (SFR) as ∝(1+z)α, thereby allowing astrophysical uncertainties to partially mimic the cosmological suppression of structures in WDM models. Using a maximum likelihood estimator on two different z>4 GRB subsamples (including two bursts at z>8), we constrain mx≳1.6-1.8 keV at 95% C.L., when marginalized over a flat prior in α. We further estimate that 5 years of a SVOM-like mission would tighten these constraints to mx≳2.3 keV. Our results show that GRBs are a powerful probe of high-redshift structures, providing robust and competitive constraints on mx.}, author = {de Souza, R. S. and Mesinger, A. and Ferrara, A. and Haiman, Zoltán and Perna, R. and Yoshida, N.}, issn = {0035-8711}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {4}, pages = {3218--3227}, publisher = {Oxford University Press}, title = {{Constraints on warm dark matter models from high-redshift long gamma-ray bursts}}, doi = {10.1093/mnras/stt674}, volume = {432}, year = {2013}, } @article{17653, abstract = {Observations of quasars at redshifts z > 6 reveal that 10^9 Msol supermassive black holes (SMBHs) had already formed when the Universe was < 0.9 Gyr old. One hypothesis for the origins of these SMBHs is that they grew from the remnants of the first generation of massive stars, which formed in low-mass (~ 10^5 to 10^6 Msol) dark matter minihaloes at z > 20. This is the regime where baryonic streaming motions--the relative velocities of baryons with respect to dark matter in the early Universe--most strongly inhibit star formation by suppressing gas infall and cooling. We investigate the impact of this effect on the growth of the first SMBHs using a suite of high-fidelity, ellipsoidal-collapse Monte Carlo merger-tree simulations. We find that the suppression of seed BH formation by the streaming motions significantly reduces the number density of the most massive BHs at z > 15, but the residual effect at lower redshifts is essentially negligible. The streaming motions can reduce by a factor of few the number density of the most luminous quasars at z ~ 10-11, where such objects could be detected by the James Webb Space Telescope. We conclude, with minor theoretical caveats, that baryonic streaming motions are unlikely to pose a significant additional obstacle to the formation of the observed high-redshift quasar SMBHs. Nor do they appreciably affect the heating and reionization histories of the Universe or the merger rates of nuclear BHs in the mass and redshift ranges of interest for proposed gravitational-wave detectors.}, author = {Tanaka, Takamitsu L. and Li, Miao and Haiman, Zoltán}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {4}, pages = {3559--3567}, publisher = {Oxford University Press}, title = {{The effect of baryonic streaming motions on the formation of the first supermassive black holes}}, doi = {10.1093/mnras/stt1553}, volume = {435}, year = {2013}, } @article{17657, abstract = {We present observations of a luminous galaxy at z = 6.573—the end of the reionization epoch—which has been spectroscopically confirmed twice. The first spectroscopic confirmation comes from slitless Hubble Space Telescope Advanced Camera for Surveys grism spectra from the PEARS survey (Probing Evolution And Reionization Spectroscopically), which show a dramatic continuum break in the spectrum at rest frame 1216 Å. The second confirmation is done with Keck + DEIMOS. The continuum is not clearly detected with ground-based spectra, but high wavelength resolution enables the Lyα emission line profile to be determined. We compare the line profile to composite line profiles at z = 4.5. The Lyα line profile shows no signature of a damping wing attenuation, confirming that the intergalactic gas is ionized at z = 6.57. Spectra of Lyman breaks at yet higher redshifts will be possible using comparably deep observations with IR-sensitive grisms, even at redshifts where Lyα is too attenuated by the neutral intergalactic medium to be detectable using traditional spectroscopy from the ground.}, author = {Rhoads, James E. and Malhotra, Sangeeta and Stern, Daniel and Dickinson, Mark and Pirzkal, Norbert and Spinrad, Hyron and Reddy, Naveen and Hathi, Nimish and Grogin, Norman and Koekemoer, Anton and Peth, Michael A. and Cohen, Seth and Zheng, Zhenya and Budavari, Tamas and Ferreras, Ignacio and Gardner, Jonathan P. and Gronwall, Caryl and Haiman, Zoltán and Kümmel, Martin and Meurer, Gerhardt and Moustakas, Leonidas and Panagia, Nino and Pasquali, Anna and Sahu, Kailash and di Serego Alighieri, Sperello and Somerville, Rachel and Straughn, Amber and Walsh, Jeremy and Windhorst, Rogier and Xu, Chun and Yan, Haojing}, issn = {0004-637X}, journal = {The Astrophysical Journal}, number = {1}, publisher = {American Astronomical Society}, title = {{A Lyman break galaxy in the epoch of reionization from hubble space telescope grism spectroscopy}}, doi = {10.1088/0004-637x/773/1/32}, volume = {773}, year = {2013}, }