[{"year":"2006","month":"03","publication_status":"published","quality_controlled":0,"day":"15","type":"conference","acknowledgement":"This research was supported in part by the AFOSR MURI grant F49620-00-1-0327 and the NSF ITR grant CCR-0225610.","abstract":[{"lang":"eng","text":"Games on graphs with ω-regular objectives provide a model for the control and synthesis of reactive systems. Every ω-regular objective can be decomposed into a safety part and a liveness part. The liveness part ensures that something good happens “eventually.” Two main strengths of the classical, infinite-limit formulation of liveness are robustness (independence from the granularity of transitions) and simplicity (abstraction of complicated time bounds). However, the classical liveness formulation suffers from the drawback that the time until something good happens may be unbounded. A stronger formulation of liveness, so-called finitary liveness, overcomes this drawback, while still retaining robustness and simplicity. Finitary liveness requires that there exists an unknown, fixed bound b such that something good happens within b transitions. While for one-shot liveness (reachability) objectives, classical and finitary liveness coincide, for repeated liveness (Büchi) objectives, the finitary formulation is strictly stronger. In this work we study games with finitary parity and Streett (fairness) objectives. We prove the determinacy of these games, present algorithms for solving these games, and characterize the memory requirements of winning strategies. Our algorithms can be used, for example, for synthesizing controllers that do not let the response time of a system increase without bound."}],"extern":1,"date_created":"2018-12-11T12:09:22Z","alternative_title":["LNCS"],"status":"public","title":"Finitary winning in omega-regular games","doi":"10.1007/11691372_17","citation":{"ama":"Chatterjee K, Henzinger TA. Finitary winning in omega-regular games. In: Vol 3920. Springer; 2006:257-271. doi:<a href=\"https://doi.org/10.1007/11691372_17\">10.1007/11691372_17</a>","ista":"Chatterjee K, Henzinger TA. 2006. Finitary winning in omega-regular games. TACAS: Tools and Algorithms for the Construction and Analysis of Systems, LNCS, vol. 3920, 257–271.","short":"K. Chatterjee, T.A. Henzinger, in:, Springer, 2006, pp. 257–271.","ieee":"K. Chatterjee and T. A. Henzinger, “Finitary winning in omega-regular games,” presented at the TACAS: Tools and Algorithms for the Construction and Analysis of Systems, 2006, vol. 3920, pp. 257–271.","apa":"Chatterjee, K., &#38; Henzinger, T. A. (2006). Finitary winning in omega-regular games (Vol. 3920, pp. 257–271). Presented at the TACAS: Tools and Algorithms for the Construction and Analysis of Systems, Springer. <a href=\"https://doi.org/10.1007/11691372_17\">https://doi.org/10.1007/11691372_17</a>","mla":"Chatterjee, Krishnendu, and Thomas A. Henzinger. <i>Finitary Winning in Omega-Regular Games</i>. Vol. 3920, Springer, 2006, pp. 257–71, doi:<a href=\"https://doi.org/10.1007/11691372_17\">10.1007/11691372_17</a>.","chicago":"Chatterjee, Krishnendu, and Thomas A Henzinger. “Finitary Winning in Omega-Regular Games,” 3920:257–71. Springer, 2006. <a href=\"https://doi.org/10.1007/11691372_17\">https://doi.org/10.1007/11691372_17</a>."},"_id":"4539","date_updated":"2021-01-12T07:59:32Z","publist_id":"183","volume":3920,"publisher":"Springer","author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","last_name":"Chatterjee","full_name":"Krishnendu Chatterjee","first_name":"Krishnendu"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000−0002−2985−7724","last_name":"Henzinger","full_name":"Thomas Henzinger","first_name":"Thomas A"}],"page":"257 - 271","conference":{"name":"TACAS: Tools and Algorithms for the Construction and Analysis of Systems"},"date_published":"2006-03-15T00:00:00Z","intvolume":"      3920"},{"extern":1,"date_created":"2018-12-11T12:09:26Z","publication_status":"published","year":"2006","month":"09","day":"01","quality_controlled":0,"abstract":[{"lang":"eng","text":"We present a compositional theory of system verification, where specifications assign real-numbered costs to systems. These costs can express a wide variety of quantitative system properties, such as resource consumption, price, or a measure of how well a system satisfies its specification. The theory supports the composition of systems and specifications, and the hiding of variables. Boolean refinement relations are replaced by real-numbered distances between descriptions of a system at different levels of detail. We show that the classical Boolean rules for compositional reasoning have quantitative counterparts in our setting. While our general theory allows costs to be specified by arbitrary cost functions, we also consider a class of linear cost functions, which give rise to an instance of our framework where all operations are computable in polynomial time."}],"acknowledgement":"Supported in part by the NSF grants CCR-0234690, CCR-0208875, and CCR-0225610; by the NSF grant CCR-0132780 and ARP grant SC20051123.","type":"conference","publist_id":"163","date_updated":"2021-01-12T07:59:37Z","publisher":"IEEE","date_published":"2006-09-01T00:00:00Z","conference":{"name":"QEST: Quantitative Evaluation of Systems"},"page":"179 - 188","author":[{"orcid":"0000-0002-4561-241X","last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","full_name":"Krishnendu Chatterjee"},{"last_name":"De Alfaro","first_name":"Luca","full_name":"de Alfaro, Luca"},{"last_name":"Faella","full_name":"Faella, Marco","first_name":"Marco"},{"orcid":"0000−0002−2985−7724","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","full_name":"Thomas Henzinger"},{"first_name":"Ritankar","full_name":"Majumdar, Ritankar S","last_name":"Majumdar"},{"first_name":"Mariëlle","full_name":"Stoelinga, Mariëlle","last_name":"Stoelinga"}],"title":"Compositional quantitative reasoning","status":"public","_id":"4549","doi":"10.1109/QEST.2006.11","citation":{"apa":"Chatterjee, K., De Alfaro, L., Faella, M., Henzinger, T. A., Majumdar, R., &#38; Stoelinga, M. (2006). Compositional quantitative reasoning (pp. 179–188). Presented at the QEST: Quantitative Evaluation of Systems, IEEE. <a href=\"https://doi.org/10.1109/QEST.2006.11\">https://doi.org/10.1109/QEST.2006.11</a>","mla":"Chatterjee, Krishnendu, et al. <i>Compositional Quantitative Reasoning</i>. IEEE, 2006, pp. 179–88, doi:<a href=\"https://doi.org/10.1109/QEST.2006.11\">10.1109/QEST.2006.11</a>.","chicago":"Chatterjee, Krishnendu, Luca De Alfaro, Marco Faella, Thomas A Henzinger, Ritankar Majumdar, and Mariëlle Stoelinga. “Compositional Quantitative Reasoning,” 179–88. IEEE, 2006. <a href=\"https://doi.org/10.1109/QEST.2006.11\">https://doi.org/10.1109/QEST.2006.11</a>.","short":"K. Chatterjee, L. De Alfaro, M. Faella, T.A. Henzinger, R. Majumdar, M. Stoelinga, in:, IEEE, 2006, pp. 179–188.","ieee":"K. Chatterjee, L. De Alfaro, M. Faella, T. A. Henzinger, R. Majumdar, and M. Stoelinga, “Compositional quantitative reasoning,” presented at the QEST: Quantitative Evaluation of Systems, 2006, pp. 179–188.","ama":"Chatterjee K, De Alfaro L, Faella M, Henzinger TA, Majumdar R, Stoelinga M. Compositional quantitative reasoning. In: IEEE; 2006:179-188. doi:<a href=\"https://doi.org/10.1109/QEST.2006.11\">10.1109/QEST.2006.11</a>","ista":"Chatterjee K, De Alfaro L, Faella M, Henzinger TA, Majumdar R, Stoelinga M. 2006. Compositional quantitative reasoning. QEST: Quantitative Evaluation of Systems, 179–188."}},{"volume":365,"publist_id":"164","date_updated":"2021-01-12T07:59:38Z","publisher":"Elsevier","date_published":"2006-08-07T00:00:00Z","author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","full_name":"Krishnendu Chatterjee","first_name":"Krishnendu"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","orcid":"0000−0002−2985−7724","full_name":"Thomas Henzinger","first_name":"Thomas A"},{"last_name":"Jurdziński","first_name":"Marcin","full_name":"Jurdziński, Marcin"}],"page":"67 - 82","intvolume":"       365","title":"Games with secure equilibria","status":"public","publication":"Theoretical Computer Science","_id":"4550","doi":"10.1016/j.tcs.2006.07.032","citation":{"apa":"Chatterjee, K., Henzinger, T. A., &#38; Jurdziński, M. (2006). Games with secure equilibria. <i>Theoretical Computer Science</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tcs.2006.07.032\">https://doi.org/10.1016/j.tcs.2006.07.032</a>","chicago":"Chatterjee, Krishnendu, Thomas A Henzinger, and Marcin Jurdziński. “Games with Secure Equilibria.” <i>Theoretical Computer Science</i>. Elsevier, 2006. <a href=\"https://doi.org/10.1016/j.tcs.2006.07.032\">https://doi.org/10.1016/j.tcs.2006.07.032</a>.","mla":"Chatterjee, Krishnendu, et al. “Games with Secure Equilibria.” <i>Theoretical Computer Science</i>, vol. 365, no. 1–2, Elsevier, 2006, pp. 67–82, doi:<a href=\"https://doi.org/10.1016/j.tcs.2006.07.032\">10.1016/j.tcs.2006.07.032</a>.","short":"K. Chatterjee, T.A. Henzinger, M. Jurdziński, Theoretical Computer Science 365 (2006) 67–82.","ieee":"K. Chatterjee, T. A. Henzinger, and M. Jurdziński, “Games with secure equilibria,” <i>Theoretical Computer Science</i>, vol. 365, no. 1–2. Elsevier, pp. 67–82, 2006.","ama":"Chatterjee K, Henzinger TA, Jurdziński M. Games with secure equilibria. <i>Theoretical Computer Science</i>. 2006;365(1-2):67-82. doi:<a href=\"https://doi.org/10.1016/j.tcs.2006.07.032\">10.1016/j.tcs.2006.07.032</a>","ista":"Chatterjee K, Henzinger TA, Jurdziński M. 2006. Games with secure equilibria. Theoretical Computer Science. 365(1–2), 67–82."},"issue":"1-2","extern":1,"date_created":"2018-12-11T12:09:26Z","publication_status":"published","year":"2006","month":"08","day":"07","quality_controlled":0,"abstract":[{"lang":"eng","text":"In 2-player non-zero-sum games, Nash equilibria capture the options for rational behavior if each player attempts to maximize her payoff. In contrast to classical game theory, we consider lexicographic objectives: first, each player tries to maximize her own payoff, and then, the player tries to minimize the opponent's payoff. Such objectives arise naturally in the verification of systems with multiple components. There, instead of proving that each component satisfies its specification no matter how the other components behave, it sometimes suffices to prove that each component satisfies its specification provided that the other components satisfy their specifications. We say that a Nash equilibrium is secure if it is an equilibrium with respect to the lexicographic objectives of both players. We prove that in graph games with Borel winning conditions, which include the games that arise in verification, there may be several Nash equilibria, but there is always a unique maximal payoff profile of a secure equilibrium. We show how this equilibrium can be computed in the case of ω-regular winning conditions, and we characterize the memory requirements of strategies that achieve the equilibrium."}],"type":"journal_article"},{"publisher":"Springer","volume":3884,"publist_id":"161","date_updated":"2021-01-12T07:59:38Z","intvolume":"      3884","date_published":"2006-02-14T00:00:00Z","conference":{"name":"STACS: Theoretical Aspects of Computer Science"},"author":[{"full_name":"Krishnendu Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","orcid":"0000-0002-4561-241X"},{"full_name":"Majumdar, Ritankar S","first_name":"Ritankar","last_name":"Majumdar"},{"orcid":"0000−0002−2985−7724","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","full_name":"Thomas Henzinger"}],"page":"325 - 336","title":"Markov decision processes with multiple objectives","status":"public","alternative_title":["LNCS"],"_id":"4551","citation":{"chicago":"Chatterjee, Krishnendu, Ritankar Majumdar, and Thomas A Henzinger. “Markov Decision Processes with Multiple Objectives,” 3884:325–36. Springer, 2006. <a href=\"https://doi.org/10.1007/11672142_26\">https://doi.org/10.1007/11672142_26</a>.","mla":"Chatterjee, Krishnendu, et al. <i>Markov Decision Processes with Multiple Objectives</i>. Vol. 3884, Springer, 2006, pp. 325–36, doi:<a href=\"https://doi.org/10.1007/11672142_26\">10.1007/11672142_26</a>.","apa":"Chatterjee, K., Majumdar, R., &#38; Henzinger, T. A. (2006). Markov decision processes with multiple objectives (Vol. 3884, pp. 325–336). Presented at the STACS: Theoretical Aspects of Computer Science, Springer. <a href=\"https://doi.org/10.1007/11672142_26\">https://doi.org/10.1007/11672142_26</a>","ieee":"K. Chatterjee, R. Majumdar, and T. A. Henzinger, “Markov decision processes with multiple objectives,” presented at the STACS: Theoretical Aspects of Computer Science, 2006, vol. 3884, pp. 325–336.","short":"K. Chatterjee, R. Majumdar, T.A. Henzinger, in:, Springer, 2006, pp. 325–336.","ista":"Chatterjee K, Majumdar R, Henzinger TA. 2006. Markov decision processes with multiple objectives. STACS: Theoretical Aspects of Computer Science, LNCS, vol. 3884, 325–336.","ama":"Chatterjee K, Majumdar R, Henzinger TA. Markov decision processes with multiple objectives. In: Vol 3884. Springer; 2006:325-336. doi:<a href=\"https://doi.org/10.1007/11672142_26\">10.1007/11672142_26</a>"},"doi":"10.1007/11672142_26","extern":1,"date_created":"2018-12-11T12:09:26Z","publication_status":"published","month":"02","year":"2006","acknowledgement":"This research was supported in part by the AFOSR MURI grant F49620-00-1-0327, and the NSF grants CCR-0225610, CCR-0234690, and CCR-0427202.","abstract":[{"lang":"eng","text":"We consider Markov decision processes (MDPs) with multiple discounted reward objectives. Such MDPs occur in design problems where one wishes to simultaneously optimize several criteria, for example, latency and power. The possible trade-offs between the different objectives are characterized by the Pareto curve. We show that every Pareto-optimal point can be achieved by a memoryless strategy; however, unlike in the single-objective case, the memoryless strategy may require randomization. Moreover, we show that the Pareto curve can be approximated in polynomial time in the size of the MDP. Additionally, we study the problem if a given value vector is realizable by any strategy, and show that it can be decided in polynomial time; but the question whether it is realizable by a deterministic memoryless strategy is NP-complete. These results provide efficient algorithms for design exploration in MDP models with multiple objectives.\nThis research was supported in part by the AFOSR MURI grant F49620-00-1-0327, and the NSF grants CCR-0225610, CCR-0234690, and CCR-0427202. "}],"type":"conference","day":"14","quality_controlled":0},{"date_created":"2018-12-11T12:09:26Z","extern":1,"type":"conference","abstract":[{"lang":"eng","text":"A concurrent reachability game is a two-player game played on a graph: at each state, the players simultaneously and independently select moves; the two moves determine jointly a probability distribution over the successor states. The objective for player 1 consists in reaching a set of target states; the objective for player 2 is to prevent this, so that the game is zero-sum. Our contributions are two-fold. First, we present a simple proof of the fact that in concurrent reachability games, for all epsilon &gt; 0, memoryless epsilon-optimal strategies exist. A memoryless strategy is independent of the history of plays, and an epsilon-optimal strategy achieves the objective with probability within epsilon of the value of the game. In contrast to previous proofs of this fact, which rely on the limit behavior of discounted games using advanced Puisieux series analysis, our proof is elementary and combinatorial. Second, we present a strategy-improvement (a.k.a. policy-iteration) algorithm for concurrent games with reachability objectives."}],"quality_controlled":0,"day":"01","year":"2006","month":"01","publication_status":"published","page":"291 - 300","conference":{"name":"QEST: Quantitative Evaluation of Systems"},"author":[{"first_name":"Krishnendu","full_name":"Krishnendu Chatterjee","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Luca","full_name":"de Alfaro, Luca","last_name":"De Alfaro"},{"last_name":"Henzinger","orcid":"0000−0002−2985−7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","full_name":"Thomas Henzinger"}],"date_published":"2006-01-01T00:00:00Z","publisher":"IEEE","date_updated":"2021-01-12T07:59:39Z","publist_id":"162","doi":"10.1109/QEST.2006.48","citation":{"mla":"Chatterjee, Krishnendu, et al. <i>Strategy Improvement for Concurrent Reachability Games</i>. IEEE, 2006, pp. 291–300, doi:<a href=\"https://doi.org/10.1109/QEST.2006.48\">10.1109/QEST.2006.48</a>.","chicago":"Chatterjee, Krishnendu, Luca De Alfaro, and Thomas A Henzinger. “Strategy Improvement for Concurrent Reachability Games,” 291–300. IEEE, 2006. <a href=\"https://doi.org/10.1109/QEST.2006.48\">https://doi.org/10.1109/QEST.2006.48</a>.","apa":"Chatterjee, K., De Alfaro, L., &#38; Henzinger, T. A. (2006). Strategy improvement for concurrent reachability games (pp. 291–300). Presented at the QEST: Quantitative Evaluation of Systems, IEEE. <a href=\"https://doi.org/10.1109/QEST.2006.48\">https://doi.org/10.1109/QEST.2006.48</a>","ista":"Chatterjee K, De Alfaro L, Henzinger TA. 2006. Strategy improvement for concurrent reachability games. QEST: Quantitative Evaluation of Systems, 291–300.","ama":"Chatterjee K, De Alfaro L, Henzinger TA. Strategy improvement for concurrent reachability games. In: IEEE; 2006:291-300. doi:<a href=\"https://doi.org/10.1109/QEST.2006.48\">10.1109/QEST.2006.48</a>","ieee":"K. Chatterjee, L. De Alfaro, and T. A. Henzinger, “Strategy improvement for concurrent reachability games,” presented at the QEST: Quantitative Evaluation of Systems, 2006, pp. 291–300.","short":"K. Chatterjee, L. De Alfaro, T.A. Henzinger, in:, IEEE, 2006, pp. 291–300."},"_id":"4552","status":"public","title":"Strategy improvement for concurrent reachability games"},{"quality_controlled":0,"day":"08","type":"conference","abstract":[{"text":"Many software model checkers are based on predicate abstraction. If the verification goal depends on pointer structures, the approach does not work well, because it is difficult to find adequate predicate abstractions for the heap. In contrast, shape analysis, which uses graph-based heap abstractions, can provide a compact representation of recursive data structures. We integrate shape analysis into the software model checker Blast. Because shape analysis is expensive, we do not apply it globally. Instead, we ensure that, like predicates, shape graphs are computed and stored locally, only where necessary for proving the verification goal. To achieve this, we extend lazy abstraction refinement, which so far has been used only for predicate abstractions, to three-valued logical structures. This approach does not only increase the precision of model checking, but it also increases the efficiency of shape analysis. We implemented the technique by extending Blast with calls to Tvla.","lang":"eng"}],"year":"2006","month":"08","publication_status":"published","date_created":"2018-12-11T12:09:33Z","extern":1,"citation":{"apa":"Beyer, D., Henzinger, T. A., &#38; Théoduloz, G. (2006). Lazy shape analysis (Vol. 4144, pp. 532–546). Presented at the CAV: Computer Aided Verification, Springer. <a href=\"https://doi.org/10.1007/11817963_48\">https://doi.org/10.1007/11817963_48</a>","mla":"Beyer, Dirk, et al. <i>Lazy Shape Analysis</i>. Vol. 4144, Springer, 2006, pp. 532–46, doi:<a href=\"https://doi.org/10.1007/11817963_48\">10.1007/11817963_48</a>.","chicago":"Beyer, Dirk, Thomas A Henzinger, and Grégory Théoduloz. “Lazy Shape Analysis,” 4144:532–46. Springer, 2006. <a href=\"https://doi.org/10.1007/11817963_48\">https://doi.org/10.1007/11817963_48</a>.","short":"D. Beyer, T.A. Henzinger, G. Théoduloz, in:, Springer, 2006, pp. 532–546.","ieee":"D. Beyer, T. A. Henzinger, and G. Théoduloz, “Lazy shape analysis,” presented at the CAV: Computer Aided Verification, 2006, vol. 4144, pp. 532–546.","ama":"Beyer D, Henzinger TA, Théoduloz G. Lazy shape analysis. In: Vol 4144. Springer; 2006:532-546. doi:<a href=\"https://doi.org/10.1007/11817963_48\">10.1007/11817963_48</a>","ista":"Beyer D, Henzinger TA, Théoduloz G. 2006. Lazy shape analysis. CAV: Computer Aided Verification, LNCS, vol. 4144, 532–546."},"doi":"10.1007/11817963_48","_id":"4574","alternative_title":["LNCS"],"status":"public","title":"Lazy shape analysis","conference":{"name":"CAV: Computer Aided Verification"},"page":"532 - 546","author":[{"last_name":"Beyer","first_name":"Dirk","full_name":"Beyer, Dirk"},{"full_name":"Thomas Henzinger","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","orcid":"0000−0002−2985−7724"},{"last_name":"Théoduloz","first_name":"Grégory","full_name":"Théoduloz, Grégory"}],"date_published":"2006-08-08T00:00:00Z","intvolume":"      4144","date_updated":"2021-01-12T07:59:49Z","volume":4144,"publist_id":"133","publisher":"Springer"},{"month":"09","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2005","publication_status":"published","keyword":["Hyperlink Analysis","World Wide Web"],"quality_controlled":"1","day":"06","publication_identifier":{"isbn":["9781595931689"]},"type":"conference","abstract":[{"text":"We give a short survey of the use of hyperlink analysis in web search engine ranking and sketch other applications of hyperlink analysis in the web space.","lang":"eng"}],"oa_version":"None","extern":"1","date_created":"2022-07-29T10:47:23Z","scopus_import":"1","status":"public","title":"Hyperlink analysis on the world wide web","citation":{"ieee":"M. Henzinger, “Hyperlink analysis on the world wide web,” in <i>Proceedings of the 16th ACM conference on Hypertext and hypermedia</i>, Salzburg, Austria, 2005, pp. 1–3.","short":"M. Henzinger, in:, Proceedings of the 16th ACM Conference on Hypertext and Hypermedia, Association for Computing Machinery, 2005, pp. 1–3.","ista":"Henzinger M. 2005. Hyperlink analysis on the world wide web. Proceedings of the 16th ACM conference on Hypertext and hypermedia. HYPERTEXT: Conference on Hypertext and Hypermedia, 1–3.","ama":"Henzinger M. Hyperlink analysis on the world wide web. In: <i>Proceedings of the 16th ACM Conference on Hypertext and Hypermedia</i>. Association for Computing Machinery; 2005:1-3. doi:<a href=\"https://doi.org/10.1145/1083356.1083357\">10.1145/1083356.1083357</a>","chicago":"Henzinger, Monika. “Hyperlink Analysis on the World Wide Web.” In <i>Proceedings of the 16th ACM Conference on Hypertext and Hypermedia</i>, 1–3. Association for Computing Machinery, 2005. <a href=\"https://doi.org/10.1145/1083356.1083357\">https://doi.org/10.1145/1083356.1083357</a>.","mla":"Henzinger, Monika. “Hyperlink Analysis on the World Wide Web.” <i>Proceedings of the 16th ACM Conference on Hypertext and Hypermedia</i>, Association for Computing Machinery, 2005, pp. 1–3, doi:<a href=\"https://doi.org/10.1145/1083356.1083357\">10.1145/1083356.1083357</a>.","apa":"Henzinger, M. (2005). Hyperlink analysis on the world wide web. In <i>Proceedings of the 16th ACM conference on Hypertext and hypermedia</i> (pp. 1–3). Salzburg, Austria: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/1083356.1083357\">https://doi.org/10.1145/1083356.1083357</a>"},"doi":"10.1145/1083356.1083357","_id":"11698","publication":"Proceedings of the 16th ACM conference on Hypertext and hypermedia","date_updated":"2024-11-06T08:13:46Z","language":[{"iso":"eng"}],"article_processing_charge":"No","publisher":"Association for Computing Machinery","page":"1-3","conference":{"start_date":"2005-09-06","end_date":"2005-09-09","location":"Salzburg, Austria","name":"HYPERTEXT: Conference on Hypertext and Hypermedia"},"author":[{"full_name":"Henzinger, Monika H","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","last_name":"Henzinger","orcid":"0000-0002-5008-6530"}],"date_published":"2005-09-06T00:00:00Z"},{"article_type":"original","oa":1,"volume":55,"date_updated":"2024-11-06T08:12:50Z","intvolume":"        55","title":"An online throughput-competitive algorithm for multicast routing and admission control","status":"public","publication":"Journal of Algorithms","citation":{"apa":"Goel, A., Henzinger, M., &#38; Plotkin, S. (2005). An online throughput-competitive algorithm for multicast routing and admission control. <i>Journal of Algorithms</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jalgor.2004.11.001\">https://doi.org/10.1016/j.jalgor.2004.11.001</a>","chicago":"Goel, Ashish, Monika Henzinger, and Serge Plotkin. “An Online Throughput-Competitive Algorithm for Multicast Routing and Admission Control.” <i>Journal of Algorithms</i>. Elsevier, 2005. <a href=\"https://doi.org/10.1016/j.jalgor.2004.11.001\">https://doi.org/10.1016/j.jalgor.2004.11.001</a>.","mla":"Goel, Ashish, et al. “An Online Throughput-Competitive Algorithm for Multicast Routing and Admission Control.” <i>Journal of Algorithms</i>, vol. 55, no. 1, Elsevier, 2005, pp. 1–20, doi:<a href=\"https://doi.org/10.1016/j.jalgor.2004.11.001\">10.1016/j.jalgor.2004.11.001</a>.","short":"A. Goel, M. Henzinger, S. Plotkin, Journal of Algorithms 55 (2005) 1–20.","ieee":"A. Goel, M. Henzinger, and S. Plotkin, “An online throughput-competitive algorithm for multicast routing and admission control,” <i>Journal of Algorithms</i>, vol. 55, no. 1. Elsevier, pp. 1–20, 2005.","ama":"Goel A, Henzinger M, Plotkin S. An online throughput-competitive algorithm for multicast routing and admission control. <i>Journal of Algorithms</i>. 2005;55(1):1-20. doi:<a href=\"https://doi.org/10.1016/j.jalgor.2004.11.001\">10.1016/j.jalgor.2004.11.001</a>","ista":"Goel A, Henzinger M, Plotkin S. 2005. An online throughput-competitive algorithm for multicast routing and admission control. Journal of Algorithms. 55(1), 1–20."},"doi":"10.1016/j.jalgor.2004.11.001","oa_version":"Published Version","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"04","year":"2005","abstract":[{"lang":"eng","text":"We present the first polylog-competitive online algorithm for the general multicast admission control and routing problem in the throughput model. The ratio of the number of requests accepted by the optimum offline algorithm to the expected number of requests accepted by our algorithm is O((log n + log log M)(log n + log M) log n), where M is the number of multicast groups and n is the number of nodes in the graph. We show that this is close to optimum by presenting an\r\nΩ(log n log M) lower bound on this ratio for any randomized online algorithm against an oblivious adversary, when M is much larger than the link capacities. Our lower bound applies even in the restricted case where the link capacities are much larger than bandwidth requested by a single multicast. We also present a simple proof showing that it is impossible to be competitive against an adaptive online adversary.\r\nAs in the previous online routing algorithms, our algorithm uses edge-costs when deciding on which is the best path to use. In contrast to the previous competitive algorithms in the throughput model, our cost is not a direct function of the edge load. The new cost definition allows us to decouple the effects of routing and admission decisions of different multicast groups."}],"related_material":{"record":[{"relation":"earlier_version","id":"11926","status":"public"}]},"type":"journal_article","day":"01","quality_controlled":"1","publisher":"Elsevier","article_processing_charge":"No","language":[{"iso":"eng"}],"date_published":"2005-04-01T00:00:00Z","author":[{"last_name":"Goel","first_name":"Ashish","full_name":"Goel, Ashish"},{"full_name":"Henzinger, Monika H","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","orcid":"0000-0002-5008-6530","last_name":"Henzinger"},{"first_name":"Serge","full_name":"Plotkin, Serge","last_name":"Plotkin"}],"page":"1-20","scopus_import":"1","_id":"11763","extern":"1","issue":"1","date_created":"2022-08-08T12:03:00Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.jalgor.2004.11.001"}],"publication_identifier":{"issn":["0196-6774"]}},{"type":"journal_article","related_material":{"record":[{"status":"public","relation":"earlier_version","id":"11860"}]},"abstract":[{"text":"Many daily activities present information in the form of a stream of text, and often people can benefit from additional information on the topic discussed. TV broadcast news can be treated as one such stream of text; in this paper we discuss finding news articles on the web that are relevant to news currently being broadcast.\r\n\r\nWe evaluated a variety of algorithms for this problem, looking at the impact of inverse document frequency, stemming, compounds, history, and query length on the relevance and coverage of news articles returned in real time during a broadcast. We also evaluated several postprocessing techniques for improving the precision, including reranking using additional terms, reranking by document similarity, and filtering on document similarity. For the best algorithm, 84–91% of the articles found were relevant, with at least 64% of the articles being on the exact topic of the broadcast. In addition, a relevant article was found for at least 70% of the topics.","lang":"eng"}],"quality_controlled":"1","day":"01","year":"2005","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"06","publication_status":"published","oa_version":"None","doi":"10.1007/s11280-004-4870-6","citation":{"ieee":"M. Henzinger, B.-W. Chang, B. Milch, and S. Brin, “Query-free news search,” <i>World Wide Web</i>, vol. 8, no. 2. Springer Nature, pp. 101–126, 2005.","short":"M. Henzinger, B.-W. Chang, B. Milch, S. Brin, World Wide Web 8 (2005) 101–126.","ista":"Henzinger M, Chang B-W, Milch B, Brin S. 2005. Query-free news search. World Wide Web. 8(2), 101–126.","ama":"Henzinger M, Chang B-W, Milch B, Brin S. Query-free news search. <i>World Wide Web</i>. 2005;8(2):101-126. doi:<a href=\"https://doi.org/10.1007/s11280-004-4870-6\">10.1007/s11280-004-4870-6</a>","mla":"Henzinger, Monika, et al. “Query-Free News Search.” <i>World Wide Web</i>, vol. 8, no. 2, Springer Nature, 2005, pp. 101–26, doi:<a href=\"https://doi.org/10.1007/s11280-004-4870-6\">10.1007/s11280-004-4870-6</a>.","chicago":"Henzinger, Monika, Bay-Wei Chang, Brian Milch, and Sergey Brin. “Query-Free News Search.” <i>World Wide Web</i>. Springer Nature, 2005. <a href=\"https://doi.org/10.1007/s11280-004-4870-6\">https://doi.org/10.1007/s11280-004-4870-6</a>.","apa":"Henzinger, M., Chang, B.-W., Milch, B., &#38; Brin, S. (2005). Query-free news search. <i>World Wide Web</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11280-004-4870-6\">https://doi.org/10.1007/s11280-004-4870-6</a>"},"publication":"World Wide Web","status":"public","title":"Query-free news search","intvolume":"         8","article_type":"original","date_updated":"2024-11-06T12:24:36Z","volume":8,"publication_identifier":{"issn":["1386-145X"],"eissn":["1573-1413"]},"date_created":"2022-08-17T11:16:56Z","extern":"1","issue":"2","_id":"11904","scopus_import":"1","page":"101-126","author":[{"id":"540c9bbd-f2de-11ec-812d-d04a5be85630","orcid":"0000-0002-5008-6530","last_name":"Henzinger","full_name":"Henzinger, Monika H","first_name":"Monika H"},{"first_name":"Bay-Wei","full_name":"Chang, Bay-Wei","last_name":"Chang"},{"first_name":"Brian","full_name":"Milch, Brian","last_name":"Milch"},{"last_name":"Brin","first_name":"Sergey","full_name":"Brin, Sergey"}],"date_published":"2005-06-01T00:00:00Z","article_processing_charge":"No","language":[{"iso":"eng"}],"publisher":"Springer Nature"},{"month":"01","year":"2005","publication_status":"published","quality_controlled":0,"day":"01","type":"review","abstract":[{"text":"Our understanding of the role played by neurotransmitter receptors in the developing brain has advanced in recent years. The major excitatory and inhibitory neurotransmitters in the brain, glutamate and GABA, activate both ionotropic (ligand-gated ion channels) and metabotropic (G protein-coupled) receptors, and are generally associated with neuronal communication in the mature brain. However, before the emergence of their role in neurotransmission in adulthood, they also act to influence earlier developmental events, some of which occur prior to synapse formation: such as proliferation, migration, differentiation or survival processes during neural development. To fulfill these actions in the constructing of the nervous system, different types of glutamate and GABA receptors need to be expressed both at the right time and at the right place. The identification by molecular cloning of 16 ionotropic glutamate receptor subunits, eight metabotropic glutamate receptor subtypes, 21 ionotropic and two metabotropic GABA receptor subunits, some of which exist in alternatively splice variants, has enriched our appreciation of how molecular diversity leads to functional diversity in the brain. It now appears that many different types of glutamate and GABA receptor subunits have prominent expression in the embryonic and/or postnatal brain, whereas others are mainly present in the adult brain. Although the significance of this differential expression of subunits is not fully understood, it appears that the change in subunit composition is essential for normal development in particular brain regions. This review focuses on emerging information relating to the expression and role of glutamatergic and GABAergic neurotransmitter receptors during prenatal and postnatal development.","lang":"eng"}],"issue":"3","extern":1,"date_created":"2018-12-11T11:58:51Z","status":"public","title":"Glutamate and GABA receptor signalling in the developing brain","citation":{"ista":"Luján R, Shigemoto R, López Bendito G. 2005. Glutamate and GABA receptor signalling in the developing brain. Neuroscience. 130(3), 567–580.","ama":"Luján R, Shigemoto R, López Bendito G. Glutamate and GABA receptor signalling in the developing brain. <i>Neuroscience</i>. 2005;130(3):567-580. doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2004.09.042\">10.1016/j.neuroscience.2004.09.042</a>","ieee":"R. Luján, R. Shigemoto, and G. López Bendito, “Glutamate and GABA receptor signalling in the developing brain,” <i>Neuroscience</i>, vol. 130, no. 3. Elsevier, pp. 567–580, 2005.","short":"R. Luján, R. Shigemoto, G. López Bendito, Neuroscience 130 (2005) 567–580.","mla":"Luján, Rafael, et al. “Glutamate and GABA Receptor Signalling in the Developing Brain.” <i>Neuroscience</i>, vol. 130, no. 3, Elsevier, 2005, pp. 567–80, doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2004.09.042\">10.1016/j.neuroscience.2004.09.042</a>.","chicago":"Luján, Rafael, Ryuichi Shigemoto, and Guillermina López Bendito. “Glutamate and GABA Receptor Signalling in the Developing Brain.” <i>Neuroscience</i>. Elsevier, 2005. <a href=\"https://doi.org/10.1016/j.neuroscience.2004.09.042\">https://doi.org/10.1016/j.neuroscience.2004.09.042</a>.","apa":"Luján, R., Shigemoto, R., &#38; López Bendito, G. (2005). Glutamate and GABA receptor signalling in the developing brain. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuroscience.2004.09.042\">https://doi.org/10.1016/j.neuroscience.2004.09.042</a>"},"doi":"10.1016/j.neuroscience.2004.09.042","_id":"2647","publication":"Neuroscience","date_updated":"2020-07-14T12:45:44Z","volume":130,"publist_id":"4250","publisher":"Elsevier","author":[{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"López-Bendito, Guillermina","first_name":"Guillermina","last_name":"López Bendito"}],"page":"567 - 580","date_published":"2005-01-01T00:00:00Z","intvolume":"       130"},{"extern":1,"issue":"8","date_created":"2018-12-11T11:58:52Z","publication_status":"published","month":"04","year":"2005","abstract":[{"lang":"eng","text":"Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are involved in the control of neuronal excitability and plasticity. In this study, we used immunoblotting and immunohistochemical techniques to reveal the developmental expression and subcellular distribution of the HCN1 subunit in the cerebellar cortex. During postnatal development, the spatio-temporal expression of HCN1 correlated well with the morphological events occurring during the ontogenesis of cerebellar interneurons. Using immunoblotting techniques, HCN1 was weakly detected during the first postnatal week and continued to increase throughout postnatal development, peaking at postnatal day (P)15. At the light-microscopic level, HCN1 immunoreactivity was very weak until P7 whereas from P10-12 to adulthood it was strongly detected in the lower third of the molecular layer and in the Purkinje cell layer. HCN1 was present in axons running through the molecular layer and in the pericellular basket around Purkinje cells at P12, but in the periaxonal plexus (the pinceau) surrounding their initial segment only after P15. Using immunofluorescence, HCN1 colocalized with GAD65 and synaptophysin, demonstrating that the subunit was present in inhibitory axons and axon terminals. At the electron-microscopic level, in adulthood, HCN1 immunoparticles were detected at postsynaptic sites in basket and Purkinje cells but most immunoparticles were found at presynaptic sites in basket cell axons and in terminals. In the axon terminals, the distribution of HCN1 was relatively uniform along the extrasynaptic plasma membrane; this was confirmed using quantitative techniques. The present findings suggest that HCN1 channels may provide a significant route for modulating co-ordinated cerebellar synaptic transmission through basket cells."}],"type":"journal_article","day":"01","quality_controlled":0,"publisher":"Wiley-Blackwell","publist_id":"4248","volume":21,"date_updated":"2021-01-12T06:58:48Z","intvolume":"        21","date_published":"2005-04-01T00:00:00Z","page":"2073 - 2082","author":[{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"first_name":"José","full_name":"Albasanz, José L","last_name":"Albasanz"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Juíz","full_name":"Juíz, José M","first_name":"José"}],"title":"Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum","status":"public","_id":"2648","publication":"European Journal of Neuroscience","citation":{"ieee":"R. Luján, J. Albasanz, R. Shigemoto, and J. Juíz, “Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum,” <i>European Journal of Neuroscience</i>, vol. 21, no. 8. Wiley-Blackwell, pp. 2073–2082, 2005.","short":"R. Luján, J. Albasanz, R. Shigemoto, J. Juíz, European Journal of Neuroscience 21 (2005) 2073–2082.","ista":"Luján R, Albasanz J, Shigemoto R, Juíz J. 2005. Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. European Journal of Neuroscience. 21(8), 2073–2082.","ama":"Luján R, Albasanz J, Shigemoto R, Juíz J. Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. <i>European Journal of Neuroscience</i>. 2005;21(8):2073-2082. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04043.x\">10.1111/j.1460-9568.2005.04043.x</a>","chicago":"Luján, Rafael, José Albasanz, Ryuichi Shigemoto, and José Juíz. “Preferential Localization of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel Subunit HCN1 in Basket Cell Terminals of the Rat Cerebellum.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2005. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04043.x\">https://doi.org/10.1111/j.1460-9568.2005.04043.x</a>.","mla":"Luján, Rafael, et al. “Preferential Localization of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel Subunit HCN1 in Basket Cell Terminals of the Rat Cerebellum.” <i>European Journal of Neuroscience</i>, vol. 21, no. 8, Wiley-Blackwell, 2005, pp. 2073–82, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04043.x\">10.1111/j.1460-9568.2005.04043.x</a>.","apa":"Luján, R., Albasanz, J., Shigemoto, R., &#38; Juíz, J. (2005). Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04043.x\">https://doi.org/10.1111/j.1460-9568.2005.04043.x</a>"},"doi":"10.1111/j.1460-9568.2005.04043.x"},{"title":"Number and density of AMPA receptors in single synapses in immature cerebellum","status":"public","_id":"2649","publication":"Journal of Neuroscience","citation":{"ama":"Tanaka J, Matsuzaki M, Tarusawa E, et al. Number and density of AMPA receptors in single synapses in immature cerebellum. <i>Journal of Neuroscience</i>. 2005;25(4):799-807. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.4256-04.2005\">10.1523/JNEUROSCI.4256-04.2005</a>","ista":"Tanaka J, Matsuzaki M, Tarusawa E, Momiyama A, Molnár E, Kasai H, Shigemoto R. 2005. Number and density of AMPA receptors in single synapses in immature cerebellum. Journal of Neuroscience. 25(4), 799–807.","short":"J. Tanaka, M. Matsuzaki, E. Tarusawa, A. Momiyama, E. Molnár, H. Kasai, R. Shigemoto, Journal of Neuroscience 25 (2005) 799–807.","ieee":"J. Tanaka <i>et al.</i>, “Number and density of AMPA receptors in single synapses in immature cerebellum,” <i>Journal of Neuroscience</i>, vol. 25, no. 4. Society for Neuroscience, pp. 799–807, 2005.","apa":"Tanaka, J., Matsuzaki, M., Tarusawa, E., Momiyama, A., Molnár, E., Kasai, H., &#38; Shigemoto, R. (2005). Number and density of AMPA receptors in single synapses in immature cerebellum. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.4256-04.2005\">https://doi.org/10.1523/JNEUROSCI.4256-04.2005</a>","chicago":"Tanaka, Junichi, Masanori Matsuzaki, Etsuko Tarusawa, Akiko Momiyama, Elek Molnár, Haruo Kasai, and Ryuichi Shigemoto. “Number and Density of AMPA Receptors in Single Synapses in Immature Cerebellum.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2005. <a href=\"https://doi.org/10.1523/JNEUROSCI.4256-04.2005\">https://doi.org/10.1523/JNEUROSCI.4256-04.2005</a>.","mla":"Tanaka, Junichi, et al. “Number and Density of AMPA Receptors in Single Synapses in Immature Cerebellum.” <i>Journal of Neuroscience</i>, vol. 25, no. 4, Society for Neuroscience, 2005, pp. 799–807, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.4256-04.2005\">10.1523/JNEUROSCI.4256-04.2005</a>."},"doi":"10.1523/JNEUROSCI.4256-04.2005","publisher":"Society for Neuroscience","publist_id":"4249","volume":25,"date_updated":"2021-01-12T06:58:48Z","intvolume":"        25","date_published":"2005-01-26T00:00:00Z","author":[{"last_name":"Tanaka","first_name":"Junichi","full_name":"Tanaka, Junichi"},{"first_name":"Masanori","full_name":"Matsuzaki, Masanori","last_name":"Matsuzaki"},{"first_name":"Etsuko","full_name":"Tarusawa, Etsuko","last_name":"Tarusawa"},{"last_name":"Momiyama","full_name":"Momiyama, Akiko","first_name":"Akiko"},{"full_name":"Molnár, Elek","first_name":"Elek","last_name":"Molnár"},{"last_name":"Kasai","first_name":"Haruo","full_name":"Kasai, Haruo"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"page":"799 - 807","publication_status":"published","month":"01","year":"2005","abstract":[{"lang":"eng","text":"The number of ionotropic receptors in synapses is an essential factor for determining the efficacy of fast transmission. We estimated the number of functional AMPA receptors at single postsynaptic sites by a combination of two-photon uncaging of glutamate and the nonstationary fluctuation analysis in immature rat Purkinje cells (PCs), which receive a single type of excitatory input from climbing fibers. Areas of postsynaptic membrane specialization at the recorded synapses were measured by reconstruction of serial ultrathin sections. The number of functional AMPA receptors was proportional to the synaptic area with a density of ∼ 1280 receptors/μm 2. Moreover, highly sensitive freeze-fracture replica labeling revealed a homogeneous density of immunogold particles for AMPA receptors in synaptic sites (910 ± 36 particles/μm 2) and much lower density in extrasynaptic sites (19 ± 2 particles/μm 2) in the immature PCs. Our results indicate that in this developing synapse, the efficacy of transmission is determined by the synaptic area."}],"type":"journal_article","day":"26","quality_controlled":0,"extern":1,"issue":"4","date_created":"2018-12-11T11:58:52Z"},{"citation":{"chicago":"Nyíri, Gábor, Eszter Szabadits, Csaba Cserép, Ken Mackie, Ryuichi Shigemoto, and Tamás Freund. “GABAB and CB1 Cannabinoid Receptor Expression Identifies Two Types of Septal Cholinergic Neurons.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2005. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04146.x\">https://doi.org/10.1111/j.1460-9568.2005.04146.x</a>.","mla":"Nyíri, Gábor, et al. “GABAB and CB1 Cannabinoid Receptor Expression Identifies Two Types of Septal Cholinergic Neurons.” <i>European Journal of Neuroscience</i>, vol. 21, no. 11, Wiley-Blackwell, 2005, pp. 3034–42, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04146.x\">10.1111/j.1460-9568.2005.04146.x</a>.","apa":"Nyíri, G., Szabadits, E., Cserép, C., Mackie, K., Shigemoto, R., &#38; Freund, T. (2005). GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04146.x\">https://doi.org/10.1111/j.1460-9568.2005.04146.x</a>","ieee":"G. Nyíri, E. Szabadits, C. Cserép, K. Mackie, R. Shigemoto, and T. Freund, “GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons,” <i>European Journal of Neuroscience</i>, vol. 21, no. 11. Wiley-Blackwell, pp. 3034–3042, 2005.","short":"G. Nyíri, E. Szabadits, C. Cserép, K. Mackie, R. Shigemoto, T. Freund, European Journal of Neuroscience 21 (2005) 3034–3042.","ista":"Nyíri G, Szabadits E, Cserép C, Mackie K, Shigemoto R, Freund T. 2005. GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons. European Journal of Neuroscience. 21(11), 3034–3042.","ama":"Nyíri G, Szabadits E, Cserép C, Mackie K, Shigemoto R, Freund T. GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons. <i>European Journal of Neuroscience</i>. 2005;21(11):3034-3042. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04146.x\">10.1111/j.1460-9568.2005.04146.x</a>"},"doi":"10.1111/j.1460-9568.2005.04146.x","publication":"European Journal of Neuroscience","_id":"2650","status":"public","title":"GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons","page":"3034 - 3042","author":[{"last_name":"Nyíri","full_name":"Nyíri, Gábor","first_name":"Gábor"},{"first_name":"Eszter","full_name":"Szabadits, Eszter","last_name":"Szabadits"},{"last_name":"Cserép","full_name":"Cserép, Csaba","first_name":"Csaba"},{"last_name":"Mackie","first_name":"Ken","full_name":"Mackie, Ken P"},{"full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"full_name":"Freund, Tamás F","first_name":"Tamás","last_name":"Freund"}],"date_published":"2005-06-01T00:00:00Z","intvolume":"        21","date_updated":"2021-01-12T06:58:49Z","publist_id":"4247","volume":21,"publisher":"Wiley-Blackwell","quality_controlled":0,"day":"01","type":"journal_article","abstract":[{"text":"Septohippocampal cholinergic neurons play key roles in learning and memory processes, and in the generation of hippocampal theta rhythm. The range of receptors for endogenous modulators expressed on these neurons is unclear. Here we describe GABAB 1a/b receptor (GABABR) and type 1 cannabinoid receptor (CB1R) expression in rat septal cholinergic [i.e. choline acetyltransferase (ChAT)-positive] cells. Using double immunofluorescent staining, we found that almost two-thirds of the cholinergic cells in the rat medial septum were GABABR positive, and that these cells had significantly larger somata than did GABABR-negative cholinergic neurons. We detected CB1R labelling in somata after axonal protein transport was blocked by colchicine. In these animals about one-third of the cholinergic cells were CB1R positive. These cells again had larger somata than CB1R-negative cholinergic neurons. The analyses confirmed that the size of GABABR-positive and CB 1R-positive cholinergic cells were alike, and all CB 1R-positive cholinergic cells were GABABR positive as well. CB1R-positive cells were invariably ChAT positive. All retrogradely labelled septohippocampal cholinergic cells were positive for GABABR and at least half of them also for CB1R. These data shed light on the existence of at least two cholinergic cell types in the medial septum: one expresses GABABR and CB1R, has large somata and projects to the hippocampus, whereas the other is negative for GABABR and CB1R and has smaller somata. The results also suggest that cholinergic transmission in the hippocampus is fine-tuned by endocannabinoid signalling.","lang":"eng"}],"year":"2005","month":"06","publication_status":"published","date_created":"2018-12-11T11:58:52Z","issue":"11","extern":1},{"title":"Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis","status":"public","_id":"2651","publication":"Journal of Andrology","citation":{"chicago":"Kanbara, Kiyoto, Keiko Okamoto, Sakashi Nomura, Takeshi Kaneko, Ryuichi Shigemoto, Haruhito Azuma, Yoji Katsuoka, and Masahiko Watanabe. “Cellular Localization of GABA and GABAB Receptor Subunit Proteins during Spermiogenesis in Rat Testis.” <i>Journal of Andrology</i>. American Society of Andrology, 2005. <a href=\"https://doi.org/10.2164/jandrol.04185\">https://doi.org/10.2164/jandrol.04185</a>.","mla":"Kanbara, Kiyoto, et al. “Cellular Localization of GABA and GABAB Receptor Subunit Proteins during Spermiogenesis in Rat Testis.” <i>Journal of Andrology</i>, vol. 26, no. 4, American Society of Andrology, 2005, pp. 485–93, doi:<a href=\"https://doi.org/10.2164/jandrol.04185\">10.2164/jandrol.04185</a>.","apa":"Kanbara, K., Okamoto, K., Nomura, S., Kaneko, T., Shigemoto, R., Azuma, H., … Watanabe, M. (2005). Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis. <i>Journal of Andrology</i>. American Society of Andrology. <a href=\"https://doi.org/10.2164/jandrol.04185\">https://doi.org/10.2164/jandrol.04185</a>","ieee":"K. Kanbara <i>et al.</i>, “Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis,” <i>Journal of Andrology</i>, vol. 26, no. 4. American Society of Andrology, pp. 485–493, 2005.","short":"K. Kanbara, K. Okamoto, S. Nomura, T. Kaneko, R. Shigemoto, H. Azuma, Y. Katsuoka, M. Watanabe, Journal of Andrology 26 (2005) 485–493.","ista":"Kanbara K, Okamoto K, Nomura S, Kaneko T, Shigemoto R, Azuma H, Katsuoka Y, Watanabe M. 2005. Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis. Journal of Andrology. 26(4), 485–493.","ama":"Kanbara K, Okamoto K, Nomura S, et al. Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis. <i>Journal of Andrology</i>. 2005;26(4):485-493. doi:<a href=\"https://doi.org/10.2164/jandrol.04185\">10.2164/jandrol.04185</a>"},"doi":"10.2164/jandrol.04185","publisher":"American Society of Andrology","publist_id":"4246","volume":26,"date_updated":"2021-01-12T06:58:50Z","intvolume":"        26","date_published":"2005-07-01T00:00:00Z","page":"485 - 493","author":[{"full_name":"Kanbara, Kiyoto","first_name":"Kiyoto","last_name":"Kanbara"},{"full_name":"Okamoto, Keiko","first_name":"Keiko","last_name":"Okamoto"},{"last_name":"Nomura","first_name":"Sakashi","full_name":"Nomura, Sakashi"},{"last_name":"Kaneko","first_name":"Takeshi","full_name":"Kaneko, Takeshi"},{"full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"last_name":"Azuma","first_name":"Haruhito","full_name":"Azuma, Haruhito"},{"last_name":"Katsuoka","first_name":"Yoji","full_name":"Katsuoka, Yoji"},{"last_name":"Watanabe","full_name":"Watanabe, Masahiko","first_name":"Masahiko"}],"publication_status":"published","month":"07","year":"2005","abstract":[{"text":"The GABAergic system, a major inhibitory regulator in the central nervous system, may also play important roles in peripheral nonneuronal tissues and cells. Recent studies showed that GABAB receptor is expressed in testis and sperm. To understand the role of the GABAergic system in spermiogenesis, we examined cellular localization of GABA and GABAB receptor subunits in rat spermatids by immunocytochemistry. Immunoreactivity for GABA was detected around acrosomal granules of spermatids during the Golgi and cap phases. GABAB(1) immunoreactivity was observed in the acrosomal vesicle of spermatids in Golgi phase, and during cap phase, this reactivity expanded to the entire region of the acrosome covering the nuclear membrane. The level of reactivity decreased gradually with maturation of spermatids. In contrast, GABAB(2) immunoreactivity was not observed in spermatids during Golgi phase but was detected in the equatorial region during cap phase. Both GABA immunoreactivity and GABAB(2) immunoreactivity were transferred to the residual cytoplasm during the release of spermatozoa. Electron microscopic immunocytochemistry revealed that, during cap phase, GABA and GABAB(1) were distributed within the whole acrosomal vesicle but not in the acrosomal granule. GABAB(2) immunoreactivity was observed in the narrow space between the inner acrosomal and nuclear membrane and was limited to the equatorial region of the spermatid head. These results indicate that the GABAergic system might be involved in regulation of spermiogenesis.","lang":"eng"}],"type":"journal_article","day":"01","quality_controlled":0,"extern":1,"issue":"4","date_created":"2018-12-11T11:58:52Z"},{"doi":"10.1523/JNEUROSCI.1135-05.2005","citation":{"apa":"Price, C., Cauli, B., Kovács, E., Kulik, Á., Lambolez, B., Shigemoto, R., &#38; Capogna, M. (2005). Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.1135-05.2005\">https://doi.org/10.1523/JNEUROSCI.1135-05.2005</a>","chicago":"Price, Christopher, Bruno Cauli, Endre Kovács, Ákos Kulik, Bertrand Lambolez, Ryuichi Shigemoto, and Marco Capogna. “Neurogliaform Neurons Form a Novel Inhibitory Network in the Hippocampal CA1 Area.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2005. <a href=\"https://doi.org/10.1523/JNEUROSCI.1135-05.2005\">https://doi.org/10.1523/JNEUROSCI.1135-05.2005</a>.","mla":"Price, Christopher, et al. “Neurogliaform Neurons Form a Novel Inhibitory Network in the Hippocampal CA1 Area.” <i>Journal of Neuroscience</i>, vol. 25, no. 29, Society for Neuroscience, 2005, pp. 6775–86, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1135-05.2005\">10.1523/JNEUROSCI.1135-05.2005</a>.","short":"C. Price, B. Cauli, E. Kovács, Á. Kulik, B. Lambolez, R. Shigemoto, M. Capogna, Journal of Neuroscience 25 (2005) 6775–6786.","ieee":"C. Price <i>et al.</i>, “Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area,” <i>Journal of Neuroscience</i>, vol. 25, no. 29. Society for Neuroscience, pp. 6775–6786, 2005.","ama":"Price C, Cauli B, Kovács E, et al. Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. <i>Journal of Neuroscience</i>. 2005;25(29):6775-6786. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1135-05.2005\">10.1523/JNEUROSCI.1135-05.2005</a>","ista":"Price C, Cauli B, Kovács E, Kulik Á, Lambolez B, Shigemoto R, Capogna M. 2005. Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. Journal of Neuroscience. 25(29), 6775–6786."},"publication":"Journal of Neuroscience","_id":"2652","status":"public","title":"Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area","page":"6775 - 6786","author":[{"first_name":"Christopher","full_name":"Price, Christopher J","last_name":"Price"},{"last_name":"Cauli","first_name":"Bruno","full_name":"Cauli, Bruno"},{"last_name":"Kovács","first_name":"Endre","full_name":"Kovács, Endre R"},{"full_name":"Kulik, Ákos","first_name":"Ákos","last_name":"Kulik"},{"full_name":"Lambolez, Bertrand","first_name":"Bertrand","last_name":"Lambolez"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi"},{"last_name":"Capogna","full_name":"Capogna,Marco","first_name":"Marco"}],"date_published":"2005-07-20T00:00:00Z","intvolume":"        25","date_updated":"2021-01-12T06:58:50Z","publist_id":"4245","volume":25,"publisher":"Society for Neuroscience","quality_controlled":0,"day":"20","type":"journal_article","abstract":[{"lang":"eng","text":"We studied neurogliaform neurons in the stratum lacunosum moleculare of the CA1 hippocampal area. These interneurons have short stellate dendrites and an extensive axonal arbor mainly located in the stratum lacunosum moleculare. Single-cell reverse transcription-PCR showed that these neurons were GABAergic and that the majority expressed mRNA for neuropeptide Y. Most neurogliaform neurons tested were immunoreactive for α-actinin-2, and many stratum lacunosum moleculare interneurons coexpressed α-actinin-2 and neuropeptide Y. Neurogliaform neurons received monosynaptic, DNQX-sensitive excitatory input from the perforant path, and 40 Hz stimulation of this input evoked EPSCs displaying either depression or initial facilitation, followed by depression. Paired recordings performed between neurogliaform neurons showed that 85% of pairs were electrically connected and 70% were also connected via GABAergic synapses. Injection of sine waveforms into neurons during paired recordings resulted in transmission of the waveforms through the electrical synapse. Unitary IPSCs recorded from neurogliaform pairs readily fatigued, had a slow decay, and had a strong depression of the synaptic response at a 5 Hz stimulation frequency that was antagonized by the GABA B antagonist (2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl) phosphinic acid (CGP55845). The amplitude of the first IPSC during the 5 Hz stimulation was also increased by CGP55845, suggesting a tonic inhibition of synaptic transmission. A small unitary GABA B-mediated IPSC could also be detected, providing the first evidence for such a component between GABAergic interneurons. Electron microscopic localization of the GABA B1 subunit at neurogliaform synapses revealed the protein in both presynaptic and postsynaptic membranes. Our data disclose a novel interneuronal network well suited for modulating the flow of information between the entorhinal cortex and CA1 hippocampus."}],"month":"07","year":"2005","publication_status":"published","date_created":"2018-12-11T11:58:53Z","issue":"29","extern":1},{"title":"Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling","status":"public","_id":"2653","publication":"Journal of Comparative Neurology","citation":{"chicago":"Hagiwara, Akari, Yugo Fukazawa, Maki Deguchi Tawarada, Toshihisa Ohtsuka, and Ryuichi Shigemoto. “Differential Distribution of Release-Related Proteins in the Hippocampal CA3 Area as Revealed by Freeze-Fracture Replica Labeling.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2005. <a href=\"https://doi.org/10.1002/cne.20633\">https://doi.org/10.1002/cne.20633</a>.","mla":"Hagiwara, Akari, et al. “Differential Distribution of Release-Related Proteins in the Hippocampal CA3 Area as Revealed by Freeze-Fracture Replica Labeling.” <i>Journal of Comparative Neurology</i>, vol. 489, no. 2, Wiley-Blackwell, 2005, pp. 195–216, doi:<a href=\"https://doi.org/10.1002/cne.20633\">10.1002/cne.20633</a>.","apa":"Hagiwara, A., Fukazawa, Y., Deguchi Tawarada, M., Ohtsuka, T., &#38; Shigemoto, R. (2005). Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.20633\">https://doi.org/10.1002/cne.20633</a>","ieee":"A. Hagiwara, Y. Fukazawa, M. Deguchi Tawarada, T. Ohtsuka, and R. Shigemoto, “Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling,” <i>Journal of Comparative Neurology</i>, vol. 489, no. 2. Wiley-Blackwell, pp. 195–216, 2005.","short":"A. Hagiwara, Y. Fukazawa, M. Deguchi Tawarada, T. Ohtsuka, R. Shigemoto, Journal of Comparative Neurology 489 (2005) 195–216.","ista":"Hagiwara A, Fukazawa Y, Deguchi Tawarada M, Ohtsuka T, Shigemoto R. 2005. Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling. Journal of Comparative Neurology. 489(2), 195–216.","ama":"Hagiwara A, Fukazawa Y, Deguchi Tawarada M, Ohtsuka T, Shigemoto R. Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling. <i>Journal of Comparative Neurology</i>. 2005;489(2):195-216. doi:<a href=\"https://doi.org/10.1002/cne.20633\">10.1002/cne.20633</a>"},"doi":"10.1002/cne.20633","volume":489,"publist_id":"4244","date_updated":"2021-01-12T06:58:50Z","publisher":"Wiley-Blackwell","date_published":"2005-08-22T00:00:00Z","author":[{"full_name":"Hagiwara, Akari","first_name":"Akari","last_name":"Hagiwara"},{"last_name":"Fukazawa","first_name":"Yugo","full_name":"Fukazawa, Yugo"},{"first_name":"Maki","full_name":"Deguchi-Tawarada, Maki","last_name":"Deguchi Tawarada"},{"full_name":"Ohtsuka, Toshihisa","first_name":"Toshihisa","last_name":"Ohtsuka"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"page":"195 - 216","intvolume":"       489","publication_status":"published","year":"2005","month":"08","day":"22","quality_controlled":0,"abstract":[{"text":"Synaptic vesicle release occurs at a specialized membrane domain known as the presynaptic active zone (AZ). Several membrane proteins are involved in the vesicle release processes such as docking, priming, and exocytotic fusion. Cytomatrix at the active zone (CAZ) proteins are structural components of the AZ and are highly concentrated in it. Localization of other release-related proteins including target soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (t-SNARE) proteins, however, has not been well demonstrated in the AZ. Here, we used sodium dodecyl sulfate-digested freeze-fracture replica labeling (SDS-FRL) to analyze quantitatively the distribution of CAZ and t-SNARE proteins in the hippocampal CA3 area. The AZ in replicated membrane was identified by immunolabeling for CAZ proteins (CAZ-associated structural protein [CAST] and Bassoon). Clusters of immunogold particles for these proteins were found on the P-face of presynaptic terminals of the mossy fiber and associational/commissural (AJC) fiber. Co-labeling with CAST revealed distribution of the t-SNARE proteins syntaxin and synaptosomal-associated protein of 25 kDa (SNAP-25) in the AZ as well as in the extrasynaptic membrane surrounding the AZ (SZ). Quantitative analysis demonstrated that the density of immunoparticles for CAST in the AZ was more than 100 times higher than in the SZ, whereas that for syntaxin and SNAP-25 was not significantly different between the AZ and SZ in both the A/C and mossy fiber terminals. These results support the involvement of the t-SNARE proteins in exocytotic fusion in the AZ and the role of CAST in specialization of the membrane domain for the AZ.","lang":"eng"}],"type":"journal_article","issue":"2","extern":1,"date_created":"2018-12-11T11:58:53Z"},{"date_created":"2018-12-11T11:58:53Z","extern":1,"issue":"45","abstract":[{"lang":"eng","text":"Presynaptic metabotropic glutamate receptors (mGluRs) show a highly selective expression and subcellular location in nerve terminals modulating neurotransmitter release. We have demonstrated that alternatively spliced variants of mGluR8, mGluR8a and mGluR8b, have an overlapping distribution in the hippocampus, and besides perforant path terminals, they are expressed in the presynaptic active zone of boutons making synapses selectively with several types of GABAergic interneurons, primarily in the stratum oriens. Boutons labeled for mGluR8 formed either type I or type II synapses, and the latter were GABAergic. Some mGluR8-positive boutons also expressed mGluR7 or vasoactive intestinal polypeptide. Interneurons strongly immunopositive for the muscarinic M2 or the mGlu1 receptors were the primary targets of mGluR8-containing terminals in the stratum oriens, but only neurochemically distinct subsets were innervated by mGluR8-enriched terminals. The majority of M2-positive neurons were mGluR8 innervated, but a minority, which expresses somatostatin, was not. Rare neurons coexpressing calretinin and M2 were consistently targeted by mGluR8-positive boutons. In vivo recording and labeling of an mGluR8-decorated and strongly M2-positive interneuron revealed a trilaminar cell with complex spike bursts during theta oscillations and strong discharge during sharp wave/ripple events. The trilaminar cell had a large projection from the CA1 area to the subiculum and a preferential innervation of interneurons in the CA1 area in addition to pyramidal cell somata and dendrites. The postsynaptic interneuron type-specific expression of the high-efficacy presynaptic mGluR8 in both putative glutamatergic and in identified GABAergic terminals predicts a role in adjusting the activity of interneurons depending on the level of network activity."}],"type":"journal_article","day":"09","quality_controlled":0,"publication_status":"published","month":"11","year":"2005","intvolume":"        25","date_published":"2005-11-09T00:00:00Z","page":"10520 - 10536","author":[{"first_name":"Francesco","full_name":"Ferraguti, Francesco","last_name":"Ferraguti"},{"first_name":"Thomas","full_name":"Klausberger,Thomas","last_name":"Klausberger"},{"full_name":"Cobden, Philip M","first_name":"Philip","last_name":"Cobden"},{"full_name":"Baude, Agnès","first_name":"Agnès","last_name":"Baude"},{"last_name":"Roberts","first_name":"John","full_name":"Roberts, John D"},{"last_name":"Szűcs","full_name":"Szűcs, Péter","first_name":"Péter"},{"first_name":"Ayae","full_name":"Kinoshita, Ayae","last_name":"Kinoshita"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi"},{"full_name":"Somogyi, Péter","first_name":"Péter","last_name":"Somogyi"},{"last_name":"Dalezios","first_name":"Yannis","full_name":"Dalezios, Yannis"}],"publisher":"Society for Neuroscience","publist_id":"4242","volume":25,"date_updated":"2021-01-12T06:58:51Z","publication":"Journal of Neuroscience","_id":"2654","doi":"10.1523/JNEUROSCI.2547-05.2005","citation":{"ama":"Ferraguti F, Klausberger T, Cobden P, et al.  Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. <i>Journal of Neuroscience</i>. 2005;25(45):10520-10536. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2547-05.2005\">10.1523/JNEUROSCI.2547-05.2005</a>","ista":"Ferraguti F, Klausberger T, Cobden P, Baude A, Roberts J, Szűcs P, Kinoshita A, Shigemoto R, Somogyi P, Dalezios Y. 2005.  Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. Journal of Neuroscience. 25(45), 10520–10536.","short":"F. Ferraguti, T. Klausberger, P. Cobden, A. Baude, J. Roberts, P. Szűcs, A. Kinoshita, R. Shigemoto, P. Somogyi, Y. Dalezios, Journal of Neuroscience 25 (2005) 10520–10536.","ieee":"F. Ferraguti <i>et al.</i>, “ Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus,” <i>Journal of Neuroscience</i>, vol. 25, no. 45. Society for Neuroscience, pp. 10520–10536, 2005.","apa":"Ferraguti, F., Klausberger, T., Cobden, P., Baude, A., Roberts, J., Szűcs, P., … Dalezios, Y. (2005).  Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.2547-05.2005\">https://doi.org/10.1523/JNEUROSCI.2547-05.2005</a>","mla":"Ferraguti, Francesco, et al. “ Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus.” <i>Journal of Neuroscience</i>, vol. 25, no. 45, Society for Neuroscience, 2005, pp. 10520–36, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2547-05.2005\">10.1523/JNEUROSCI.2547-05.2005</a>.","chicago":"Ferraguti, Francesco, Thomas Klausberger, Philip Cobden, Agnès Baude, John Roberts, Péter Szűcs, Ayae Kinoshita, Ryuichi Shigemoto, Péter Somogyi, and Yannis Dalezios. “ Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2005. <a href=\"https://doi.org/10.1523/JNEUROSCI.2547-05.2005\">https://doi.org/10.1523/JNEUROSCI.2547-05.2005</a>."},"title":" Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus","status":"public"},{"publication_status":"published","year":"2005","month":"10","day":"05","quality_controlled":0,"abstract":[{"lang":"eng","text":"Input-dependent left-right asymmetry of NMDA receptor ε2 (NR2B) subunit allocation was discovered in hippocampal Schaffer collateral (Sch) and commissural fiber pyramidal cell synapses (Kawakami et al., 2003). To investigate whether this asymmetrical ε2 allocation is also related to the types of the postsynaptic cells, we compared postembedding immunogold labeling for ε2 in left and right Sch synapses on pyramidal cells and interneurons. To facilitate the detection of ε2 density difference, we used ε1 (NR2A) knock-out (KO) mice, which have a simplified NMDA receptor subunit composition. The labeling density for ε2 but not ζ1 (NR1) and subtype 2/3 glutamate receptor (GluR2/3) in Sch-CA1 pyramidal cell synapses was significantly different between the left and right hippocampus with opposite directions in strata oriens and radiatum; the left to right ratio of ε2 labeling density was 1:1.50 in stratum oriens and 1.44:1 in stratum radiatum. No significant difference, however, was detected in CA1 stratum radiatum between the left and right Sch-GluR4-positive (mostly parvalbumin-positive) and Sch-GluR4-negative interneuron synapses. Consistent with the anatomical asymmetry, the amplitude ratio of NMDA EPSCs to non-NMDA EPSCs in pyramidal cells was approximately two times larger in right than left stratum radiatum and vice versa in stratum oriens of ε1 KO mice. Moreover, the amplitude of long-term potentiation in the Sch-CA1 synapses of left stratum radiatum was significantly larger than that in the right corresponding synapses. These results indicate that the asymmetry of ε2 distribution is target cell specific, resulting in the left-right difference in NMDA receptor content and plasticity in Sch-CA1 pyramidal cell synapses in ε1 KO mice."}],"type":"journal_article","issue":"40","extern":1,"date_created":"2018-12-11T11:58:54Z","title":"Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice","status":"public","_id":"2655","publication":"Journal of Neuroscience","doi":"10.1523/JNEUROSCI.2134-05.2005","citation":{"apa":"Wu, Y., Kawakami, R., Shinohara, Y., Fukaya, M., Sakimura, K., Mishina, M., … Shigemoto, R. (2005). Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.2134-05.2005\">https://doi.org/10.1523/JNEUROSCI.2134-05.2005</a>","chicago":"Wu, Yue, Ryosuke Kawakami, Yoshiaki Shinohara, Masahiro Fukaya, Kenji Sakimura, Masayoshi Mishina, Masahiko Watanabe, Isao Ito, and Ryuichi Shigemoto. “Target-Cell-Specific Left-Right Asymmetry of NMDA Receptor Content in Schaffer Collateral Synapses in Ε1/NR2A Knock-out Mice.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2005. <a href=\"https://doi.org/10.1523/JNEUROSCI.2134-05.2005\">https://doi.org/10.1523/JNEUROSCI.2134-05.2005</a>.","mla":"Wu, Yue, et al. “Target-Cell-Specific Left-Right Asymmetry of NMDA Receptor Content in Schaffer Collateral Synapses in Ε1/NR2A Knock-out Mice.” <i>Journal of Neuroscience</i>, vol. 25, no. 40, Society for Neuroscience, 2005, pp. 9213–26, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2134-05.2005\">10.1523/JNEUROSCI.2134-05.2005</a>.","short":"Y. Wu, R. Kawakami, Y. Shinohara, M. Fukaya, K. Sakimura, M. Mishina, M. Watanabe, I. Ito, R. Shigemoto, Journal of Neuroscience 25 (2005) 9213–9226.","ieee":"Y. Wu <i>et al.</i>, “Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice,” <i>Journal of Neuroscience</i>, vol. 25, no. 40. Society for Neuroscience, pp. 9213–9226, 2005.","ama":"Wu Y, Kawakami R, Shinohara Y, et al. Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice. <i>Journal of Neuroscience</i>. 2005;25(40):9213-9226. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2134-05.2005\">10.1523/JNEUROSCI.2134-05.2005</a>","ista":"Wu Y, Kawakami R, Shinohara Y, Fukaya M, Sakimura K, Mishina M, Watanabe M, Ito I, Shigemoto R. 2005. Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice. Journal of Neuroscience. 25(40), 9213–9226."},"volume":25,"publist_id":"4243","date_updated":"2021-01-12T06:58:51Z","publisher":"Society for Neuroscience","date_published":"2005-10-05T00:00:00Z","author":[{"full_name":"Wu, Yue","first_name":"Yue","last_name":"Wu"},{"last_name":"Kawakami","first_name":"Ryosuke","full_name":"Kawakami, Ryosuke"},{"first_name":"Yoshiaki","full_name":"Shinohara, Yoshiaki","last_name":"Shinohara"},{"full_name":"Fukaya, Masahiro","first_name":"Masahiro","last_name":"Fukaya"},{"first_name":"Kenji","full_name":"Sakimura, Kenji","last_name":"Sakimura"},{"last_name":"Mishina","first_name":"Masayoshi","full_name":"Mishina, Masayoshi"},{"full_name":"Watanabe, Masahiko","first_name":"Masahiko","last_name":"Watanabe"},{"first_name":"Isao","full_name":"Ito, Isao","last_name":"Ito"},{"full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"}],"page":"9213 - 9226","intvolume":"        25"},{"issue":"3","extern":1,"date_created":"2018-12-11T11:58:54Z","publication_status":"published","month":"11","year":"2005","day":"18","quality_controlled":0,"abstract":[{"lang":"eng","text":"Previous studies have shown that neurons in the sacral dorsal commissural nucleus (SDCN) express neurokinin-1 receptor (NK1R) and can be modulated by the co-release of GABA and glycine (Gly) from single presynaptic terminal. These results raise the possibility that GABA/Gly-cocontaining terminals might make synaptic contacts with NK1R-expressing neurons in the SDCN. In order to provide morphological evidence for this hypothesis, the triple-immunohistochemical studies were performed in the SDCN. Triple-immunofluorescence histochemical study showed that some axon terminals in close association with NK1R-immunopositive (NK1R-ip) neurons in the SDCN were immunopositive for both glutamic acid decarboxylase (GAD) and glycine transporter 2 (GlyT2). In electron microscopic dual- and triple-immunohistochemistry for GAD/GlyT2, GAD/NK1R, GlyT2/NK1R, or GAD/GlyT2/NK1R also revealed dually labeled (GAD/GlyT2-ip) synaptic terminals upon SDCN neurons, as well as GAD- and/or GlyT2-ip axon terminals in synaptic contact with NK1R-ip SDCN neurons. These results suggested that some synaptic terminals upon NK1R-expressing SDCN neurons co-released both GABA and Gly."}],"type":"journal_article","volume":388,"publist_id":"4241","date_updated":"2021-01-12T06:58:51Z","publisher":"Elsevier","date_published":"2005-11-18T00:00:00Z","author":[{"full_name":"Feng, Yu-Peng","first_name":"Yu","last_name":"Feng"},{"last_name":"Li","full_name":"Li, Yun-Qing","first_name":"Yun"},{"last_name":"Wang","first_name":"Wen","full_name":"Wang, Wen"},{"first_name":"Sheng","full_name":"Wu, Sheng-Xi","last_name":"Wu"},{"first_name":"Tao","full_name":"Chen, Tao","last_name":"Chen"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"}],"page":"144 - 148","intvolume":"       388","title":"Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat","status":"public","publication":"Neuroscience Letters","_id":"2656","doi":"10.1016/j.neulet.2005.06.068","citation":{"apa":"Feng, Y., Li, Y., Wang, W., Wu, S., Chen, T., Shigemoto, R., &#38; Mizuno, N. (2005). Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">https://doi.org/10.1016/j.neulet.2005.06.068</a>","chicago":"Feng, Yu, Yun Li, Wen Wang, Sheng Wu, Tao Chen, Ryuichi Shigemoto, and Noboru Mizuno. “Morphological Evidence for GABA/Glycine-Cocontaining Terminals in Synaptic Contact with Neurokinin-1 Receptor-Expressing Neurons in the Sacral Dorsal Commissural Nucleus of the Rat.” <i>Neuroscience Letters</i>. Elsevier, 2005. <a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">https://doi.org/10.1016/j.neulet.2005.06.068</a>.","mla":"Feng, Yu, et al. “Morphological Evidence for GABA/Glycine-Cocontaining Terminals in Synaptic Contact with Neurokinin-1 Receptor-Expressing Neurons in the Sacral Dorsal Commissural Nucleus of the Rat.” <i>Neuroscience Letters</i>, vol. 388, no. 3, Elsevier, 2005, pp. 144–48, doi:<a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">10.1016/j.neulet.2005.06.068</a>.","short":"Y. Feng, Y. Li, W. Wang, S. Wu, T. Chen, R. Shigemoto, N. Mizuno, Neuroscience Letters 388 (2005) 144–148.","ieee":"Y. Feng <i>et al.</i>, “Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat,” <i>Neuroscience Letters</i>, vol. 388, no. 3. Elsevier, pp. 144–148, 2005.","ama":"Feng Y, Li Y, Wang W, et al. Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat. <i>Neuroscience Letters</i>. 2005;388(3):144-148. doi:<a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">10.1016/j.neulet.2005.06.068</a>","ista":"Feng Y, Li Y, Wang W, Wu S, Chen T, Shigemoto R, Mizuno N. 2005. Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat. Neuroscience Letters. 388(3), 144–148."}},{"publisher":"Wiley-Blackwell","publist_id":"4240","volume":22,"date_updated":"2021-01-12T06:58:52Z","intvolume":"        22","date_published":"2005-12-01T00:00:00Z","page":"3241 - 3254","author":[{"full_name":"Kaneda, Katsuyuki","first_name":"Katsuyuki","last_name":"Kaneda"},{"full_name":"Tachibana, Yoshihisa","first_name":"Yoshihisa","last_name":"Tachibana"},{"first_name":"Michiko","full_name":"Imanishi, Michiko","last_name":"Imanishi"},{"first_name":"Hitoshi","full_name":"Kita, Hitoshi","last_name":"Kita"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi"},{"first_name":"Atsushi","full_name":"Nambu, Atsushi","last_name":"Nambu"},{"first_name":"Masahiko","full_name":"Takada, Masahiko","last_name":"Takada"}],"title":"Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys","status":"public","publication":"European Journal of Neuroscience","_id":"2658","doi":"10.1111/j.1460-9568.2005.04488.x","citation":{"apa":"Kaneda, K., Tachibana, Y., Imanishi, M., Kita, H., Shigemoto, R., Nambu, A., &#38; Takada, M. (2005). Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04488.x\">https://doi.org/10.1111/j.1460-9568.2005.04488.x</a>","mla":"Kaneda, Katsuyuki, et al. “Down-Regulation of Metabotropic Glutamate Receptor 1α in Globus Pallidus and Substantia Nigra of Parkinsonian Monkeys.” <i>European Journal of Neuroscience</i>, vol. 22, no. 12, Wiley-Blackwell, 2005, pp. 3241–54, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04488.x\">10.1111/j.1460-9568.2005.04488.x</a>.","chicago":"Kaneda, Katsuyuki, Yoshihisa Tachibana, Michiko Imanishi, Hitoshi Kita, Ryuichi Shigemoto, Atsushi Nambu, and Masahiko Takada. “Down-Regulation of Metabotropic Glutamate Receptor 1α in Globus Pallidus and Substantia Nigra of Parkinsonian Monkeys.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2005. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04488.x\">https://doi.org/10.1111/j.1460-9568.2005.04488.x</a>.","short":"K. Kaneda, Y. Tachibana, M. Imanishi, H. Kita, R. Shigemoto, A. Nambu, M. Takada, European Journal of Neuroscience 22 (2005) 3241–3254.","ieee":"K. Kaneda <i>et al.</i>, “Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys,” <i>European Journal of Neuroscience</i>, vol. 22, no. 12. Wiley-Blackwell, pp. 3241–3254, 2005.","ama":"Kaneda K, Tachibana Y, Imanishi M, et al. Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys. <i>European Journal of Neuroscience</i>. 2005;22(12):3241-3254. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04488.x\">10.1111/j.1460-9568.2005.04488.x</a>","ista":"Kaneda K, Tachibana Y, Imanishi M, Kita H, Shigemoto R, Nambu A, Takada M. 2005. Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys. European Journal of Neuroscience. 22(12), 3241–3254."},"extern":1,"issue":"12","date_created":"2018-12-11T11:58:55Z","publication_status":"published","year":"2005","month":"12","abstract":[{"text":"Enhanced glutamatergic neurotransmission via the subthalamopallidal or subthalamonigral projection seems crucial for developing parkinsonian motor signs. In the present study, the possible changes in the expression of metabotropic glutamate receptors (mGluRs) were examined in the basal ganglia of a primate model for Parkinson's disease. When the patterns of immunohistochemical localization of mGluRs in monkeys administered systemically with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were analysed in comparison with normal controls, we found that expression of mGluR1α, but not of other subtypes, was significantly reduced in the internal and external segments of the globus pallidus and the substantia nigra pars reticulata. To elucidate the functional role of mGluR1 in the control of pallidal neuron activity, extracellular unit recordings combined with intrapallidal microinjections of mGluR1-related agents were then performed in normal and parkinsonian monkeys. In normal awake conditions, the spontaneous firing rates of neurons in the pallidal complex were increased by DHPG, a selective agonist of group I mGluRs, whereas they were decreased by AIDA, a selective antagonist of group I mGluRs, or LY367385, a selective antagonist of mGluR1. These electrophysiological data strongly indicate that the excitatory mechanism of pallidal neurons by glutamate is mediated at least partly through mGluR1. The effects of the mGluR1-related agents on neuronal firing in the internal pallidal segment became rather obscure after MPTP treatment. Our results suggest that the specific down-regulation of pallidal and nigral mGluR1 ot in the parkinsonian state may exert a compensatory action to reverse the overactivity of the subthalamic nucleus-derived glutamatergic input that is generated in the disease.","lang":"eng"}],"type":"journal_article","day":"01","quality_controlled":0}]