[{"month":"01","quality_controlled":0,"publication_status":"published","publist_id":"4250","day":"01","_id":"2647","date_published":"2005-01-01T00:00:00Z","doi":"10.1016/j.neuroscience.2004.09.042","volume":130,"title":"Glutamate and GABA receptor signalling in the developing brain","publication":"Neuroscience","status":"public","issue":"3","date_created":"2018-12-11T11:58:51Z","extern":1,"intvolume":"       130","publisher":"Elsevier","author":[{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"López-Bendito, Guillermina","first_name":"Guillermina","last_name":"López Bendito"}],"year":"2005","abstract":[{"lang":"eng","text":"Our understanding of the role played by neurotransmitter receptors in the developing brain has advanced in recent years. The major excitatory and inhibitory neurotransmitters in the brain, glutamate and GABA, activate both ionotropic (ligand-gated ion channels) and metabotropic (G protein-coupled) receptors, and are generally associated with neuronal communication in the mature brain. However, before the emergence of their role in neurotransmission in adulthood, they also act to influence earlier developmental events, some of which occur prior to synapse formation: such as proliferation, migration, differentiation or survival processes during neural development. To fulfill these actions in the constructing of the nervous system, different types of glutamate and GABA receptors need to be expressed both at the right time and at the right place. The identification by molecular cloning of 16 ionotropic glutamate receptor subunits, eight metabotropic glutamate receptor subtypes, 21 ionotropic and two metabotropic GABA receptor subunits, some of which exist in alternatively splice variants, has enriched our appreciation of how molecular diversity leads to functional diversity in the brain. It now appears that many different types of glutamate and GABA receptor subunits have prominent expression in the embryonic and/or postnatal brain, whereas others are mainly present in the adult brain. Although the significance of this differential expression of subunits is not fully understood, it appears that the change in subunit composition is essential for normal development in particular brain regions. This review focuses on emerging information relating to the expression and role of glutamatergic and GABAergic neurotransmitter receptors during prenatal and postnatal development."}],"date_updated":"2020-07-14T12:45:44Z","type":"review","citation":{"mla":"Luján, Rafael, et al. “Glutamate and GABA Receptor Signalling in the Developing Brain.” <i>Neuroscience</i>, vol. 130, no. 3, Elsevier, 2005, pp. 567–80, doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2004.09.042\">10.1016/j.neuroscience.2004.09.042</a>.","ista":"Luján R, Shigemoto R, López Bendito G. 2005. Glutamate and GABA receptor signalling in the developing brain. Neuroscience. 130(3), 567–580.","ieee":"R. Luján, R. Shigemoto, and G. López Bendito, “Glutamate and GABA receptor signalling in the developing brain,” <i>Neuroscience</i>, vol. 130, no. 3. Elsevier, pp. 567–580, 2005.","chicago":"Luján, Rafael, Ryuichi Shigemoto, and Guillermina López Bendito. “Glutamate and GABA Receptor Signalling in the Developing Brain.” <i>Neuroscience</i>. Elsevier, 2005. <a href=\"https://doi.org/10.1016/j.neuroscience.2004.09.042\">https://doi.org/10.1016/j.neuroscience.2004.09.042</a>.","apa":"Luján, R., Shigemoto, R., &#38; López Bendito, G. (2005). Glutamate and GABA receptor signalling in the developing brain. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuroscience.2004.09.042\">https://doi.org/10.1016/j.neuroscience.2004.09.042</a>","short":"R. Luján, R. Shigemoto, G. López Bendito, Neuroscience 130 (2005) 567–580.","ama":"Luján R, Shigemoto R, López Bendito G. Glutamate and GABA receptor signalling in the developing brain. <i>Neuroscience</i>. 2005;130(3):567-580. doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2004.09.042\">10.1016/j.neuroscience.2004.09.042</a>"},"page":"567 - 580"},{"publication_status":"published","publist_id":"4248","quality_controlled":0,"month":"04","day":"01","doi":"10.1111/j.1460-9568.2005.04043.x","_id":"2648","date_published":"2005-04-01T00:00:00Z","status":"public","publication":"European Journal of Neuroscience","title":"Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum","volume":21,"issue":"8","date_created":"2018-12-11T11:58:52Z","extern":1,"abstract":[{"text":"Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are involved in the control of neuronal excitability and plasticity. In this study, we used immunoblotting and immunohistochemical techniques to reveal the developmental expression and subcellular distribution of the HCN1 subunit in the cerebellar cortex. During postnatal development, the spatio-temporal expression of HCN1 correlated well with the morphological events occurring during the ontogenesis of cerebellar interneurons. Using immunoblotting techniques, HCN1 was weakly detected during the first postnatal week and continued to increase throughout postnatal development, peaking at postnatal day (P)15. At the light-microscopic level, HCN1 immunoreactivity was very weak until P7 whereas from P10-12 to adulthood it was strongly detected in the lower third of the molecular layer and in the Purkinje cell layer. HCN1 was present in axons running through the molecular layer and in the pericellular basket around Purkinje cells at P12, but in the periaxonal plexus (the pinceau) surrounding their initial segment only after P15. Using immunofluorescence, HCN1 colocalized with GAD65 and synaptophysin, demonstrating that the subunit was present in inhibitory axons and axon terminals. At the electron-microscopic level, in adulthood, HCN1 immunoparticles were detected at postsynaptic sites in basket and Purkinje cells but most immunoparticles were found at presynaptic sites in basket cell axons and in terminals. In the axon terminals, the distribution of HCN1 was relatively uniform along the extrasynaptic plasma membrane; this was confirmed using quantitative techniques. The present findings suggest that HCN1 channels may provide a significant route for modulating co-ordinated cerebellar synaptic transmission through basket cells.","lang":"eng"}],"type":"journal_article","date_updated":"2021-01-12T06:58:48Z","year":"2005","author":[{"last_name":"Luján","first_name":"Rafael","full_name":"Luján, Rafael"},{"last_name":"Albasanz","full_name":"Albasanz, José L","first_name":"José"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"José","full_name":"Juíz, José M","last_name":"Juíz"}],"publisher":"Wiley-Blackwell","intvolume":"        21","page":"2073 - 2082","citation":{"chicago":"Luján, Rafael, José Albasanz, Ryuichi Shigemoto, and José Juíz. “Preferential Localization of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel Subunit HCN1 in Basket Cell Terminals of the Rat Cerebellum.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2005. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04043.x\">https://doi.org/10.1111/j.1460-9568.2005.04043.x</a>.","ieee":"R. Luján, J. Albasanz, R. Shigemoto, and J. Juíz, “Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum,” <i>European Journal of Neuroscience</i>, vol. 21, no. 8. Wiley-Blackwell, pp. 2073–2082, 2005.","ista":"Luján R, Albasanz J, Shigemoto R, Juíz J. 2005. Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. European Journal of Neuroscience. 21(8), 2073–2082.","mla":"Luján, Rafael, et al. “Preferential Localization of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel Subunit HCN1 in Basket Cell Terminals of the Rat Cerebellum.” <i>European Journal of Neuroscience</i>, vol. 21, no. 8, Wiley-Blackwell, 2005, pp. 2073–82, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04043.x\">10.1111/j.1460-9568.2005.04043.x</a>.","ama":"Luján R, Albasanz J, Shigemoto R, Juíz J. Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. <i>European Journal of Neuroscience</i>. 2005;21(8):2073-2082. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04043.x\">10.1111/j.1460-9568.2005.04043.x</a>","short":"R. Luján, J. Albasanz, R. Shigemoto, J. Juíz, European Journal of Neuroscience 21 (2005) 2073–2082.","apa":"Luján, R., Albasanz, J., Shigemoto, R., &#38; Juíz, J. (2005). Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04043.x\">https://doi.org/10.1111/j.1460-9568.2005.04043.x</a>"}},{"publist_id":"4249","publication_status":"published","quality_controlled":0,"month":"01","day":"26","doi":"10.1523/JNEUROSCI.4256-04.2005","date_published":"2005-01-26T00:00:00Z","_id":"2649","status":"public","title":"Number and density of AMPA receptors in single synapses in immature cerebellum","publication":"Journal of Neuroscience","volume":25,"issue":"4","date_created":"2018-12-11T11:58:52Z","extern":1,"date_updated":"2021-01-12T06:58:48Z","type":"journal_article","abstract":[{"lang":"eng","text":"The number of ionotropic receptors in synapses is an essential factor for determining the efficacy of fast transmission. We estimated the number of functional AMPA receptors at single postsynaptic sites by a combination of two-photon uncaging of glutamate and the nonstationary fluctuation analysis in immature rat Purkinje cells (PCs), which receive a single type of excitatory input from climbing fibers. Areas of postsynaptic membrane specialization at the recorded synapses were measured by reconstruction of serial ultrathin sections. The number of functional AMPA receptors was proportional to the synaptic area with a density of ∼ 1280 receptors/μm 2. Moreover, highly sensitive freeze-fracture replica labeling revealed a homogeneous density of immunogold particles for AMPA receptors in synaptic sites (910 ± 36 particles/μm 2) and much lower density in extrasynaptic sites (19 ± 2 particles/μm 2) in the immature PCs. Our results indicate that in this developing synapse, the efficacy of transmission is determined by the synaptic area."}],"year":"2005","author":[{"last_name":"Tanaka","first_name":"Junichi","full_name":"Tanaka, Junichi"},{"last_name":"Matsuzaki","full_name":"Matsuzaki, Masanori","first_name":"Masanori"},{"full_name":"Tarusawa, Etsuko","first_name":"Etsuko","last_name":"Tarusawa"},{"full_name":"Momiyama, Akiko","first_name":"Akiko","last_name":"Momiyama"},{"last_name":"Molnár","first_name":"Elek","full_name":"Molnár, Elek"},{"last_name":"Kasai","first_name":"Haruo","full_name":"Kasai, Haruo"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"}],"publisher":"Society for Neuroscience","intvolume":"        25","page":"799 - 807","citation":{"ama":"Tanaka J, Matsuzaki M, Tarusawa E, et al. Number and density of AMPA receptors in single synapses in immature cerebellum. <i>Journal of Neuroscience</i>. 2005;25(4):799-807. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.4256-04.2005\">10.1523/JNEUROSCI.4256-04.2005</a>","short":"J. Tanaka, M. Matsuzaki, E. Tarusawa, A. Momiyama, E. Molnár, H. Kasai, R. Shigemoto, Journal of Neuroscience 25 (2005) 799–807.","apa":"Tanaka, J., Matsuzaki, M., Tarusawa, E., Momiyama, A., Molnár, E., Kasai, H., &#38; Shigemoto, R. (2005). Number and density of AMPA receptors in single synapses in immature cerebellum. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.4256-04.2005\">https://doi.org/10.1523/JNEUROSCI.4256-04.2005</a>","ieee":"J. Tanaka <i>et al.</i>, “Number and density of AMPA receptors in single synapses in immature cerebellum,” <i>Journal of Neuroscience</i>, vol. 25, no. 4. Society for Neuroscience, pp. 799–807, 2005.","chicago":"Tanaka, Junichi, Masanori Matsuzaki, Etsuko Tarusawa, Akiko Momiyama, Elek Molnár, Haruo Kasai, and Ryuichi Shigemoto. “Number and Density of AMPA Receptors in Single Synapses in Immature Cerebellum.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2005. <a href=\"https://doi.org/10.1523/JNEUROSCI.4256-04.2005\">https://doi.org/10.1523/JNEUROSCI.4256-04.2005</a>.","mla":"Tanaka, Junichi, et al. “Number and Density of AMPA Receptors in Single Synapses in Immature Cerebellum.” <i>Journal of Neuroscience</i>, vol. 25, no. 4, Society for Neuroscience, 2005, pp. 799–807, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.4256-04.2005\">10.1523/JNEUROSCI.4256-04.2005</a>.","ista":"Tanaka J, Matsuzaki M, Tarusawa E, Momiyama A, Molnár E, Kasai H, Shigemoto R. 2005. Number and density of AMPA receptors in single synapses in immature cerebellum. Journal of Neuroscience. 25(4), 799–807."}},{"intvolume":"        21","publisher":"Wiley-Blackwell","author":[{"first_name":"Gábor","full_name":"Nyíri, Gábor","last_name":"Nyíri"},{"last_name":"Szabadits","first_name":"Eszter","full_name":"Szabadits, Eszter"},{"last_name":"Cserép","first_name":"Csaba","full_name":"Cserép, Csaba"},{"full_name":"Mackie, Ken P","first_name":"Ken","last_name":"Mackie"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Freund","first_name":"Tamás","full_name":"Freund, Tamás F"}],"year":"2005","type":"journal_article","abstract":[{"text":"Septohippocampal cholinergic neurons play key roles in learning and memory processes, and in the generation of hippocampal theta rhythm. The range of receptors for endogenous modulators expressed on these neurons is unclear. Here we describe GABAB 1a/b receptor (GABABR) and type 1 cannabinoid receptor (CB1R) expression in rat septal cholinergic [i.e. choline acetyltransferase (ChAT)-positive] cells. Using double immunofluorescent staining, we found that almost two-thirds of the cholinergic cells in the rat medial septum were GABABR positive, and that these cells had significantly larger somata than did GABABR-negative cholinergic neurons. We detected CB1R labelling in somata after axonal protein transport was blocked by colchicine. In these animals about one-third of the cholinergic cells were CB1R positive. These cells again had larger somata than CB1R-negative cholinergic neurons. The analyses confirmed that the size of GABABR-positive and CB 1R-positive cholinergic cells were alike, and all CB 1R-positive cholinergic cells were GABABR positive as well. CB1R-positive cells were invariably ChAT positive. All retrogradely labelled septohippocampal cholinergic cells were positive for GABABR and at least half of them also for CB1R. These data shed light on the existence of at least two cholinergic cell types in the medial septum: one expresses GABABR and CB1R, has large somata and projects to the hippocampus, whereas the other is negative for GABABR and CB1R and has smaller somata. The results also suggest that cholinergic transmission in the hippocampus is fine-tuned by endocannabinoid signalling.","lang":"eng"}],"date_updated":"2021-01-12T06:58:49Z","citation":{"apa":"Nyíri, G., Szabadits, E., Cserép, C., Mackie, K., Shigemoto, R., &#38; Freund, T. (2005). GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04146.x\">https://doi.org/10.1111/j.1460-9568.2005.04146.x</a>","ama":"Nyíri G, Szabadits E, Cserép C, Mackie K, Shigemoto R, Freund T. GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons. <i>European Journal of Neuroscience</i>. 2005;21(11):3034-3042. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04146.x\">10.1111/j.1460-9568.2005.04146.x</a>","short":"G. Nyíri, E. Szabadits, C. Cserép, K. Mackie, R. Shigemoto, T. Freund, European Journal of Neuroscience 21 (2005) 3034–3042.","ieee":"G. Nyíri, E. Szabadits, C. Cserép, K. Mackie, R. Shigemoto, and T. Freund, “GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons,” <i>European Journal of Neuroscience</i>, vol. 21, no. 11. Wiley-Blackwell, pp. 3034–3042, 2005.","chicago":"Nyíri, Gábor, Eszter Szabadits, Csaba Cserép, Ken Mackie, Ryuichi Shigemoto, and Tamás Freund. “GABAB and CB1 Cannabinoid Receptor Expression Identifies Two Types of Septal Cholinergic Neurons.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2005. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04146.x\">https://doi.org/10.1111/j.1460-9568.2005.04146.x</a>.","ista":"Nyíri G, Szabadits E, Cserép C, Mackie K, Shigemoto R, Freund T. 2005. GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons. European Journal of Neuroscience. 21(11), 3034–3042.","mla":"Nyíri, Gábor, et al. “GABAB and CB1 Cannabinoid Receptor Expression Identifies Two Types of Septal Cholinergic Neurons.” <i>European Journal of Neuroscience</i>, vol. 21, no. 11, Wiley-Blackwell, 2005, pp. 3034–42, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04146.x\">10.1111/j.1460-9568.2005.04146.x</a>."},"page":"3034 - 3042","issue":"11","date_created":"2018-12-11T11:58:52Z","extern":1,"_id":"2650","date_published":"2005-06-01T00:00:00Z","doi":"10.1111/j.1460-9568.2005.04146.x","volume":21,"publication":"European Journal of Neuroscience","title":"GABAB and CB1 cannabinoid receptor expression identifies two types of septal cholinergic neurons","status":"public","month":"06","quality_controlled":0,"publication_status":"published","publist_id":"4247","day":"01"},{"intvolume":"        26","publisher":"American Society of Andrology","year":"2005","author":[{"first_name":"Kiyoto","full_name":"Kanbara, Kiyoto","last_name":"Kanbara"},{"first_name":"Keiko","full_name":"Okamoto, Keiko","last_name":"Okamoto"},{"first_name":"Sakashi","full_name":"Nomura, Sakashi","last_name":"Nomura"},{"last_name":"Kaneko","full_name":"Kaneko, Takeshi","first_name":"Takeshi"},{"first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"last_name":"Azuma","first_name":"Haruhito","full_name":"Azuma, Haruhito"},{"last_name":"Katsuoka","full_name":"Katsuoka, Yoji","first_name":"Yoji"},{"first_name":"Masahiko","full_name":"Watanabe, Masahiko","last_name":"Watanabe"}],"date_updated":"2021-01-12T06:58:50Z","type":"journal_article","abstract":[{"lang":"eng","text":"The GABAergic system, a major inhibitory regulator in the central nervous system, may also play important roles in peripheral nonneuronal tissues and cells. Recent studies showed that GABAB receptor is expressed in testis and sperm. To understand the role of the GABAergic system in spermiogenesis, we examined cellular localization of GABA and GABAB receptor subunits in rat spermatids by immunocytochemistry. Immunoreactivity for GABA was detected around acrosomal granules of spermatids during the Golgi and cap phases. GABAB(1) immunoreactivity was observed in the acrosomal vesicle of spermatids in Golgi phase, and during cap phase, this reactivity expanded to the entire region of the acrosome covering the nuclear membrane. The level of reactivity decreased gradually with maturation of spermatids. In contrast, GABAB(2) immunoreactivity was not observed in spermatids during Golgi phase but was detected in the equatorial region during cap phase. Both GABA immunoreactivity and GABAB(2) immunoreactivity were transferred to the residual cytoplasm during the release of spermatozoa. Electron microscopic immunocytochemistry revealed that, during cap phase, GABA and GABAB(1) were distributed within the whole acrosomal vesicle but not in the acrosomal granule. GABAB(2) immunoreactivity was observed in the narrow space between the inner acrosomal and nuclear membrane and was limited to the equatorial region of the spermatid head. These results indicate that the GABAergic system might be involved in regulation of spermiogenesis."}],"citation":{"mla":"Kanbara, Kiyoto, et al. “Cellular Localization of GABA and GABAB Receptor Subunit Proteins during Spermiogenesis in Rat Testis.” <i>Journal of Andrology</i>, vol. 26, no. 4, American Society of Andrology, 2005, pp. 485–93, doi:<a href=\"https://doi.org/10.2164/jandrol.04185\">10.2164/jandrol.04185</a>.","ista":"Kanbara K, Okamoto K, Nomura S, Kaneko T, Shigemoto R, Azuma H, Katsuoka Y, Watanabe M. 2005. Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis. Journal of Andrology. 26(4), 485–493.","ieee":"K. Kanbara <i>et al.</i>, “Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis,” <i>Journal of Andrology</i>, vol. 26, no. 4. American Society of Andrology, pp. 485–493, 2005.","chicago":"Kanbara, Kiyoto, Keiko Okamoto, Sakashi Nomura, Takeshi Kaneko, Ryuichi Shigemoto, Haruhito Azuma, Yoji Katsuoka, and Masahiko Watanabe. “Cellular Localization of GABA and GABAB Receptor Subunit Proteins during Spermiogenesis in Rat Testis.” <i>Journal of Andrology</i>. American Society of Andrology, 2005. <a href=\"https://doi.org/10.2164/jandrol.04185\">https://doi.org/10.2164/jandrol.04185</a>.","apa":"Kanbara, K., Okamoto, K., Nomura, S., Kaneko, T., Shigemoto, R., Azuma, H., … Watanabe, M. (2005). Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis. <i>Journal of Andrology</i>. American Society of Andrology. <a href=\"https://doi.org/10.2164/jandrol.04185\">https://doi.org/10.2164/jandrol.04185</a>","short":"K. Kanbara, K. Okamoto, S. Nomura, T. Kaneko, R. Shigemoto, H. Azuma, Y. Katsuoka, M. Watanabe, Journal of Andrology 26 (2005) 485–493.","ama":"Kanbara K, Okamoto K, Nomura S, et al. Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis. <i>Journal of Andrology</i>. 2005;26(4):485-493. doi:<a href=\"https://doi.org/10.2164/jandrol.04185\">10.2164/jandrol.04185</a>"},"page":"485 - 493","issue":"4","date_created":"2018-12-11T11:58:52Z","extern":1,"_id":"2651","date_published":"2005-07-01T00:00:00Z","doi":"10.2164/jandrol.04185","volume":26,"title":"Cellular localization of GABA and GABAB receptor subunit proteins during spermiogenesis in rat testis","publication":"Journal of Andrology","status":"public","month":"07","quality_controlled":0,"publication_status":"published","publist_id":"4246","day":"01"},{"title":"Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area","publication":"Journal of Neuroscience","volume":25,"status":"public","doi":"10.1523/JNEUROSCI.1135-05.2005","_id":"2652","date_published":"2005-07-20T00:00:00Z","day":"20","quality_controlled":0,"month":"07","publist_id":"4245","publication_status":"published","citation":{"apa":"Price, C., Cauli, B., Kovács, E., Kulik, Á., Lambolez, B., Shigemoto, R., &#38; Capogna, M. (2005). Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.1135-05.2005\">https://doi.org/10.1523/JNEUROSCI.1135-05.2005</a>","ama":"Price C, Cauli B, Kovács E, et al. Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. <i>Journal of Neuroscience</i>. 2005;25(29):6775-6786. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1135-05.2005\">10.1523/JNEUROSCI.1135-05.2005</a>","short":"C. Price, B. Cauli, E. Kovács, Á. Kulik, B. Lambolez, R. Shigemoto, M. Capogna, Journal of Neuroscience 25 (2005) 6775–6786.","ieee":"C. Price <i>et al.</i>, “Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area,” <i>Journal of Neuroscience</i>, vol. 25, no. 29. Society for Neuroscience, pp. 6775–6786, 2005.","chicago":"Price, Christopher, Bruno Cauli, Endre Kovács, Ákos Kulik, Bertrand Lambolez, Ryuichi Shigemoto, and Marco Capogna. “Neurogliaform Neurons Form a Novel Inhibitory Network in the Hippocampal CA1 Area.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2005. <a href=\"https://doi.org/10.1523/JNEUROSCI.1135-05.2005\">https://doi.org/10.1523/JNEUROSCI.1135-05.2005</a>.","ista":"Price C, Cauli B, Kovács E, Kulik Á, Lambolez B, Shigemoto R, Capogna M. 2005. Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area. Journal of Neuroscience. 25(29), 6775–6786.","mla":"Price, Christopher, et al. “Neurogliaform Neurons Form a Novel Inhibitory Network in the Hippocampal CA1 Area.” <i>Journal of Neuroscience</i>, vol. 25, no. 29, Society for Neuroscience, 2005, pp. 6775–86, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1135-05.2005\">10.1523/JNEUROSCI.1135-05.2005</a>."},"page":"6775 - 6786","publisher":"Society for Neuroscience","intvolume":"        25","abstract":[{"lang":"eng","text":"We studied neurogliaform neurons in the stratum lacunosum moleculare of the CA1 hippocampal area. These interneurons have short stellate dendrites and an extensive axonal arbor mainly located in the stratum lacunosum moleculare. Single-cell reverse transcription-PCR showed that these neurons were GABAergic and that the majority expressed mRNA for neuropeptide Y. Most neurogliaform neurons tested were immunoreactive for α-actinin-2, and many stratum lacunosum moleculare interneurons coexpressed α-actinin-2 and neuropeptide Y. Neurogliaform neurons received monosynaptic, DNQX-sensitive excitatory input from the perforant path, and 40 Hz stimulation of this input evoked EPSCs displaying either depression or initial facilitation, followed by depression. Paired recordings performed between neurogliaform neurons showed that 85% of pairs were electrically connected and 70% were also connected via GABAergic synapses. Injection of sine waveforms into neurons during paired recordings resulted in transmission of the waveforms through the electrical synapse. Unitary IPSCs recorded from neurogliaform pairs readily fatigued, had a slow decay, and had a strong depression of the synaptic response at a 5 Hz stimulation frequency that was antagonized by the GABA B antagonist (2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl) phosphinic acid (CGP55845). The amplitude of the first IPSC during the 5 Hz stimulation was also increased by CGP55845, suggesting a tonic inhibition of synaptic transmission. A small unitary GABA B-mediated IPSC could also be detected, providing the first evidence for such a component between GABAergic interneurons. Electron microscopic localization of the GABA B1 subunit at neurogliaform synapses revealed the protein in both presynaptic and postsynaptic membranes. Our data disclose a novel interneuronal network well suited for modulating the flow of information between the entorhinal cortex and CA1 hippocampus."}],"date_updated":"2021-01-12T06:58:50Z","type":"journal_article","author":[{"full_name":"Price, Christopher J","first_name":"Christopher","last_name":"Price"},{"first_name":"Bruno","full_name":"Cauli, Bruno","last_name":"Cauli"},{"last_name":"Kovács","full_name":"Kovács, Endre R","first_name":"Endre"},{"last_name":"Kulik","full_name":"Kulik, Ákos","first_name":"Ákos"},{"first_name":"Bertrand","full_name":"Lambolez, Bertrand","last_name":"Lambolez"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto"},{"last_name":"Capogna","first_name":"Marco","full_name":"Capogna,Marco"}],"year":"2005","extern":1,"date_created":"2018-12-11T11:58:53Z","issue":"29"},{"doi":"10.1002/cne.20633","date_published":"2005-08-22T00:00:00Z","_id":"2653","publication":"Journal of Comparative Neurology","title":"Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling","volume":489,"status":"public","quality_controlled":0,"month":"08","publication_status":"published","publist_id":"4244","day":"22","publisher":"Wiley-Blackwell","intvolume":"       489","date_updated":"2021-01-12T06:58:50Z","abstract":[{"text":"Synaptic vesicle release occurs at a specialized membrane domain known as the presynaptic active zone (AZ). Several membrane proteins are involved in the vesicle release processes such as docking, priming, and exocytotic fusion. Cytomatrix at the active zone (CAZ) proteins are structural components of the AZ and are highly concentrated in it. Localization of other release-related proteins including target soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (t-SNARE) proteins, however, has not been well demonstrated in the AZ. Here, we used sodium dodecyl sulfate-digested freeze-fracture replica labeling (SDS-FRL) to analyze quantitatively the distribution of CAZ and t-SNARE proteins in the hippocampal CA3 area. The AZ in replicated membrane was identified by immunolabeling for CAZ proteins (CAZ-associated structural protein [CAST] and Bassoon). Clusters of immunogold particles for these proteins were found on the P-face of presynaptic terminals of the mossy fiber and associational/commissural (AJC) fiber. Co-labeling with CAST revealed distribution of the t-SNARE proteins syntaxin and synaptosomal-associated protein of 25 kDa (SNAP-25) in the AZ as well as in the extrasynaptic membrane surrounding the AZ (SZ). Quantitative analysis demonstrated that the density of immunoparticles for CAST in the AZ was more than 100 times higher than in the SZ, whereas that for syntaxin and SNAP-25 was not significantly different between the AZ and SZ in both the A/C and mossy fiber terminals. These results support the involvement of the t-SNARE proteins in exocytotic fusion in the AZ and the role of CAST in specialization of the membrane domain for the AZ.","lang":"eng"}],"type":"journal_article","author":[{"last_name":"Hagiwara","full_name":"Hagiwara, Akari","first_name":"Akari"},{"last_name":"Fukazawa","full_name":"Fukazawa, Yugo","first_name":"Yugo"},{"full_name":"Deguchi-Tawarada, Maki","first_name":"Maki","last_name":"Deguchi Tawarada"},{"first_name":"Toshihisa","full_name":"Ohtsuka, Toshihisa","last_name":"Ohtsuka"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"}],"year":"2005","citation":{"mla":"Hagiwara, Akari, et al. “Differential Distribution of Release-Related Proteins in the Hippocampal CA3 Area as Revealed by Freeze-Fracture Replica Labeling.” <i>Journal of Comparative Neurology</i>, vol. 489, no. 2, Wiley-Blackwell, 2005, pp. 195–216, doi:<a href=\"https://doi.org/10.1002/cne.20633\">10.1002/cne.20633</a>.","ista":"Hagiwara A, Fukazawa Y, Deguchi Tawarada M, Ohtsuka T, Shigemoto R. 2005. Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling. Journal of Comparative Neurology. 489(2), 195–216.","ieee":"A. Hagiwara, Y. Fukazawa, M. Deguchi Tawarada, T. Ohtsuka, and R. Shigemoto, “Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling,” <i>Journal of Comparative Neurology</i>, vol. 489, no. 2. Wiley-Blackwell, pp. 195–216, 2005.","chicago":"Hagiwara, Akari, Yugo Fukazawa, Maki Deguchi Tawarada, Toshihisa Ohtsuka, and Ryuichi Shigemoto. “Differential Distribution of Release-Related Proteins in the Hippocampal CA3 Area as Revealed by Freeze-Fracture Replica Labeling.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2005. <a href=\"https://doi.org/10.1002/cne.20633\">https://doi.org/10.1002/cne.20633</a>.","apa":"Hagiwara, A., Fukazawa, Y., Deguchi Tawarada, M., Ohtsuka, T., &#38; Shigemoto, R. (2005). Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.20633\">https://doi.org/10.1002/cne.20633</a>","short":"A. Hagiwara, Y. Fukazawa, M. Deguchi Tawarada, T. Ohtsuka, R. Shigemoto, Journal of Comparative Neurology 489 (2005) 195–216.","ama":"Hagiwara A, Fukazawa Y, Deguchi Tawarada M, Ohtsuka T, Shigemoto R. Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling. <i>Journal of Comparative Neurology</i>. 2005;489(2):195-216. doi:<a href=\"https://doi.org/10.1002/cne.20633\">10.1002/cne.20633</a>"},"page":"195 - 216","issue":"2","extern":1,"date_created":"2018-12-11T11:58:53Z"},{"status":"public","volume":25,"publication":"Journal of Neuroscience","title":" Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus","date_published":"2005-11-09T00:00:00Z","_id":"2654","doi":"10.1523/JNEUROSCI.2547-05.2005","day":"09","publication_status":"published","publist_id":"4242","month":"11","quality_controlled":0,"page":"10520 - 10536","citation":{"apa":"Ferraguti, F., Klausberger, T., Cobden, P., Baude, A., Roberts, J., Szűcs, P., … Dalezios, Y. (2005).  Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.2547-05.2005\">https://doi.org/10.1523/JNEUROSCI.2547-05.2005</a>","ama":"Ferraguti F, Klausberger T, Cobden P, et al.  Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. <i>Journal of Neuroscience</i>. 2005;25(45):10520-10536. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2547-05.2005\">10.1523/JNEUROSCI.2547-05.2005</a>","short":"F. Ferraguti, T. Klausberger, P. Cobden, A. Baude, J. Roberts, P. Szűcs, A. Kinoshita, R. Shigemoto, P. Somogyi, Y. Dalezios, Journal of Neuroscience 25 (2005) 10520–10536.","ieee":"F. Ferraguti <i>et al.</i>, “ Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus,” <i>Journal of Neuroscience</i>, vol. 25, no. 45. Society for Neuroscience, pp. 10520–10536, 2005.","chicago":"Ferraguti, Francesco, Thomas Klausberger, Philip Cobden, Agnès Baude, John Roberts, Péter Szűcs, Ayae Kinoshita, Ryuichi Shigemoto, Péter Somogyi, and Yannis Dalezios. “ Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2005. <a href=\"https://doi.org/10.1523/JNEUROSCI.2547-05.2005\">https://doi.org/10.1523/JNEUROSCI.2547-05.2005</a>.","mla":"Ferraguti, Francesco, et al. “ Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus.” <i>Journal of Neuroscience</i>, vol. 25, no. 45, Society for Neuroscience, 2005, pp. 10520–36, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2547-05.2005\">10.1523/JNEUROSCI.2547-05.2005</a>.","ista":"Ferraguti F, Klausberger T, Cobden P, Baude A, Roberts J, Szűcs P, Kinoshita A, Shigemoto R, Somogyi P, Dalezios Y. 2005.  Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. Journal of Neuroscience. 25(45), 10520–10536."},"year":"2005","author":[{"full_name":"Ferraguti, Francesco","first_name":"Francesco","last_name":"Ferraguti"},{"full_name":"Klausberger,Thomas","first_name":"Thomas","last_name":"Klausberger"},{"full_name":"Cobden, Philip M","first_name":"Philip","last_name":"Cobden"},{"last_name":"Baude","full_name":"Baude, Agnès","first_name":"Agnès"},{"first_name":"John","full_name":"Roberts, John D","last_name":"Roberts"},{"last_name":"Szűcs","full_name":"Szűcs, Péter","first_name":"Péter"},{"last_name":"Kinoshita","first_name":"Ayae","full_name":"Kinoshita, Ayae"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Somogyi, Péter","first_name":"Péter","last_name":"Somogyi"},{"first_name":"Yannis","full_name":"Dalezios, Yannis","last_name":"Dalezios"}],"abstract":[{"text":"Presynaptic metabotropic glutamate receptors (mGluRs) show a highly selective expression and subcellular location in nerve terminals modulating neurotransmitter release. We have demonstrated that alternatively spliced variants of mGluR8, mGluR8a and mGluR8b, have an overlapping distribution in the hippocampus, and besides perforant path terminals, they are expressed in the presynaptic active zone of boutons making synapses selectively with several types of GABAergic interneurons, primarily in the stratum oriens. Boutons labeled for mGluR8 formed either type I or type II synapses, and the latter were GABAergic. Some mGluR8-positive boutons also expressed mGluR7 or vasoactive intestinal polypeptide. Interneurons strongly immunopositive for the muscarinic M2 or the mGlu1 receptors were the primary targets of mGluR8-containing terminals in the stratum oriens, but only neurochemically distinct subsets were innervated by mGluR8-enriched terminals. The majority of M2-positive neurons were mGluR8 innervated, but a minority, which expresses somatostatin, was not. Rare neurons coexpressing calretinin and M2 were consistently targeted by mGluR8-positive boutons. In vivo recording and labeling of an mGluR8-decorated and strongly M2-positive interneuron revealed a trilaminar cell with complex spike bursts during theta oscillations and strong discharge during sharp wave/ripple events. The trilaminar cell had a large projection from the CA1 area to the subiculum and a preferential innervation of interneurons in the CA1 area in addition to pyramidal cell somata and dendrites. The postsynaptic interneuron type-specific expression of the high-efficacy presynaptic mGluR8 in both putative glutamatergic and in identified GABAergic terminals predicts a role in adjusting the activity of interneurons depending on the level of network activity.","lang":"eng"}],"type":"journal_article","date_updated":"2021-01-12T06:58:51Z","intvolume":"        25","publisher":"Society for Neuroscience","extern":1,"date_created":"2018-12-11T11:58:53Z","issue":"45"},{"publication_status":"published","publist_id":"4243","quality_controlled":0,"month":"10","day":"05","doi":"10.1523/JNEUROSCI.2134-05.2005","_id":"2655","date_published":"2005-10-05T00:00:00Z","status":"public","publication":"Journal of Neuroscience","title":"Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice","volume":25,"issue":"40","date_created":"2018-12-11T11:58:54Z","extern":1,"date_updated":"2021-01-12T06:58:51Z","type":"journal_article","abstract":[{"lang":"eng","text":"Input-dependent left-right asymmetry of NMDA receptor ε2 (NR2B) subunit allocation was discovered in hippocampal Schaffer collateral (Sch) and commissural fiber pyramidal cell synapses (Kawakami et al., 2003). To investigate whether this asymmetrical ε2 allocation is also related to the types of the postsynaptic cells, we compared postembedding immunogold labeling for ε2 in left and right Sch synapses on pyramidal cells and interneurons. To facilitate the detection of ε2 density difference, we used ε1 (NR2A) knock-out (KO) mice, which have a simplified NMDA receptor subunit composition. The labeling density for ε2 but not ζ1 (NR1) and subtype 2/3 glutamate receptor (GluR2/3) in Sch-CA1 pyramidal cell synapses was significantly different between the left and right hippocampus with opposite directions in strata oriens and radiatum; the left to right ratio of ε2 labeling density was 1:1.50 in stratum oriens and 1.44:1 in stratum radiatum. No significant difference, however, was detected in CA1 stratum radiatum between the left and right Sch-GluR4-positive (mostly parvalbumin-positive) and Sch-GluR4-negative interneuron synapses. Consistent with the anatomical asymmetry, the amplitude ratio of NMDA EPSCs to non-NMDA EPSCs in pyramidal cells was approximately two times larger in right than left stratum radiatum and vice versa in stratum oriens of ε1 KO mice. Moreover, the amplitude of long-term potentiation in the Sch-CA1 synapses of left stratum radiatum was significantly larger than that in the right corresponding synapses. These results indicate that the asymmetry of ε2 distribution is target cell specific, resulting in the left-right difference in NMDA receptor content and plasticity in Sch-CA1 pyramidal cell synapses in ε1 KO mice."}],"author":[{"first_name":"Yue","full_name":"Wu, Yue","last_name":"Wu"},{"last_name":"Kawakami","first_name":"Ryosuke","full_name":"Kawakami, Ryosuke"},{"last_name":"Shinohara","full_name":"Shinohara, Yoshiaki","first_name":"Yoshiaki"},{"full_name":"Fukaya, Masahiro","first_name":"Masahiro","last_name":"Fukaya"},{"last_name":"Sakimura","first_name":"Kenji","full_name":"Sakimura, Kenji"},{"last_name":"Mishina","full_name":"Mishina, Masayoshi","first_name":"Masayoshi"},{"last_name":"Watanabe","first_name":"Masahiko","full_name":"Watanabe, Masahiko"},{"last_name":"Ito","first_name":"Isao","full_name":"Ito, Isao"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"year":"2005","publisher":"Society for Neuroscience","intvolume":"        25","page":"9213 - 9226","citation":{"apa":"Wu, Y., Kawakami, R., Shinohara, Y., Fukaya, M., Sakimura, K., Mishina, M., … Shigemoto, R. (2005). Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.2134-05.2005\">https://doi.org/10.1523/JNEUROSCI.2134-05.2005</a>","short":"Y. Wu, R. Kawakami, Y. Shinohara, M. Fukaya, K. Sakimura, M. Mishina, M. Watanabe, I. Ito, R. Shigemoto, Journal of Neuroscience 25 (2005) 9213–9226.","ama":"Wu Y, Kawakami R, Shinohara Y, et al. Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice. <i>Journal of Neuroscience</i>. 2005;25(40):9213-9226. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2134-05.2005\">10.1523/JNEUROSCI.2134-05.2005</a>","ista":"Wu Y, Kawakami R, Shinohara Y, Fukaya M, Sakimura K, Mishina M, Watanabe M, Ito I, Shigemoto R. 2005. Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice. Journal of Neuroscience. 25(40), 9213–9226.","mla":"Wu, Yue, et al. “Target-Cell-Specific Left-Right Asymmetry of NMDA Receptor Content in Schaffer Collateral Synapses in Ε1/NR2A Knock-out Mice.” <i>Journal of Neuroscience</i>, vol. 25, no. 40, Society for Neuroscience, 2005, pp. 9213–26, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2134-05.2005\">10.1523/JNEUROSCI.2134-05.2005</a>.","ieee":"Y. Wu <i>et al.</i>, “Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1/NR2A knock-out mice,” <i>Journal of Neuroscience</i>, vol. 25, no. 40. Society for Neuroscience, pp. 9213–9226, 2005.","chicago":"Wu, Yue, Ryosuke Kawakami, Yoshiaki Shinohara, Masahiro Fukaya, Kenji Sakimura, Masayoshi Mishina, Masahiko Watanabe, Isao Ito, and Ryuichi Shigemoto. “Target-Cell-Specific Left-Right Asymmetry of NMDA Receptor Content in Schaffer Collateral Synapses in Ε1/NR2A Knock-out Mice.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2005. <a href=\"https://doi.org/10.1523/JNEUROSCI.2134-05.2005\">https://doi.org/10.1523/JNEUROSCI.2134-05.2005</a>."}},{"citation":{"apa":"Feng, Y., Li, Y., Wang, W., Wu, S., Chen, T., Shigemoto, R., &#38; Mizuno, N. (2005). Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">https://doi.org/10.1016/j.neulet.2005.06.068</a>","short":"Y. Feng, Y. Li, W. Wang, S. Wu, T. Chen, R. Shigemoto, N. Mizuno, Neuroscience Letters 388 (2005) 144–148.","ama":"Feng Y, Li Y, Wang W, et al. Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat. <i>Neuroscience Letters</i>. 2005;388(3):144-148. doi:<a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">10.1016/j.neulet.2005.06.068</a>","mla":"Feng, Yu, et al. “Morphological Evidence for GABA/Glycine-Cocontaining Terminals in Synaptic Contact with Neurokinin-1 Receptor-Expressing Neurons in the Sacral Dorsal Commissural Nucleus of the Rat.” <i>Neuroscience Letters</i>, vol. 388, no. 3, Elsevier, 2005, pp. 144–48, doi:<a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">10.1016/j.neulet.2005.06.068</a>.","ista":"Feng Y, Li Y, Wang W, Wu S, Chen T, Shigemoto R, Mizuno N. 2005. Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat. Neuroscience Letters. 388(3), 144–148.","ieee":"Y. Feng <i>et al.</i>, “Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat,” <i>Neuroscience Letters</i>, vol. 388, no. 3. Elsevier, pp. 144–148, 2005.","chicago":"Feng, Yu, Yun Li, Wen Wang, Sheng Wu, Tao Chen, Ryuichi Shigemoto, and Noboru Mizuno. “Morphological Evidence for GABA/Glycine-Cocontaining Terminals in Synaptic Contact with Neurokinin-1 Receptor-Expressing Neurons in the Sacral Dorsal Commissural Nucleus of the Rat.” <i>Neuroscience Letters</i>. Elsevier, 2005. <a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">https://doi.org/10.1016/j.neulet.2005.06.068</a>."},"page":"144 - 148","intvolume":"       388","publisher":"Elsevier","year":"2005","author":[{"last_name":"Feng","full_name":"Feng, Yu-Peng","first_name":"Yu"},{"last_name":"Li","full_name":"Li, Yun-Qing","first_name":"Yun"},{"last_name":"Wang","first_name":"Wen","full_name":"Wang, Wen"},{"last_name":"Wu","first_name":"Sheng","full_name":"Wu, Sheng-Xi"},{"first_name":"Tao","full_name":"Chen, Tao","last_name":"Chen"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi"},{"last_name":"Mizuno","first_name":"Noboru","full_name":"Mizuno, Noboru"}],"date_updated":"2021-01-12T06:58:51Z","type":"journal_article","abstract":[{"lang":"eng","text":"Previous studies have shown that neurons in the sacral dorsal commissural nucleus (SDCN) express neurokinin-1 receptor (NK1R) and can be modulated by the co-release of GABA and glycine (Gly) from single presynaptic terminal. These results raise the possibility that GABA/Gly-cocontaining terminals might make synaptic contacts with NK1R-expressing neurons in the SDCN. In order to provide morphological evidence for this hypothesis, the triple-immunohistochemical studies were performed in the SDCN. Triple-immunofluorescence histochemical study showed that some axon terminals in close association with NK1R-immunopositive (NK1R-ip) neurons in the SDCN were immunopositive for both glutamic acid decarboxylase (GAD) and glycine transporter 2 (GlyT2). In electron microscopic dual- and triple-immunohistochemistry for GAD/GlyT2, GAD/NK1R, GlyT2/NK1R, or GAD/GlyT2/NK1R also revealed dually labeled (GAD/GlyT2-ip) synaptic terminals upon SDCN neurons, as well as GAD- and/or GlyT2-ip axon terminals in synaptic contact with NK1R-ip SDCN neurons. These results suggested that some synaptic terminals upon NK1R-expressing SDCN neurons co-released both GABA and Gly."}],"date_created":"2018-12-11T11:58:54Z","extern":1,"issue":"3","volume":388,"publication":"Neuroscience Letters","title":"Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat","status":"public","date_published":"2005-11-18T00:00:00Z","_id":"2656","doi":"10.1016/j.neulet.2005.06.068","day":"18","month":"11","quality_controlled":0,"publication_status":"published","publist_id":"4241"},{"title":"Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys","publication":"European Journal of Neuroscience","volume":22,"status":"public","doi":"10.1111/j.1460-9568.2005.04488.x","_id":"2658","date_published":"2005-12-01T00:00:00Z","day":"01","quality_controlled":0,"month":"12","publication_status":"published","publist_id":"4240","citation":{"ista":"Kaneda K, Tachibana Y, Imanishi M, Kita H, Shigemoto R, Nambu A, Takada M. 2005. Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys. European Journal of Neuroscience. 22(12), 3241–3254.","mla":"Kaneda, Katsuyuki, et al. “Down-Regulation of Metabotropic Glutamate Receptor 1α in Globus Pallidus and Substantia Nigra of Parkinsonian Monkeys.” <i>European Journal of Neuroscience</i>, vol. 22, no. 12, Wiley-Blackwell, 2005, pp. 3241–54, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04488.x\">10.1111/j.1460-9568.2005.04488.x</a>.","ieee":"K. Kaneda <i>et al.</i>, “Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys,” <i>European Journal of Neuroscience</i>, vol. 22, no. 12. Wiley-Blackwell, pp. 3241–3254, 2005.","chicago":"Kaneda, Katsuyuki, Yoshihisa Tachibana, Michiko Imanishi, Hitoshi Kita, Ryuichi Shigemoto, Atsushi Nambu, and Masahiko Takada. “Down-Regulation of Metabotropic Glutamate Receptor 1α in Globus Pallidus and Substantia Nigra of Parkinsonian Monkeys.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2005. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04488.x\">https://doi.org/10.1111/j.1460-9568.2005.04488.x</a>.","apa":"Kaneda, K., Tachibana, Y., Imanishi, M., Kita, H., Shigemoto, R., Nambu, A., &#38; Takada, M. (2005). Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2005.04488.x\">https://doi.org/10.1111/j.1460-9568.2005.04488.x</a>","short":"K. Kaneda, Y. Tachibana, M. Imanishi, H. Kita, R. Shigemoto, A. Nambu, M. Takada, European Journal of Neuroscience 22 (2005) 3241–3254.","ama":"Kaneda K, Tachibana Y, Imanishi M, et al. Down-regulation of metabotropic glutamate receptor 1α in globus pallidus and substantia nigra of parkinsonian monkeys. <i>European Journal of Neuroscience</i>. 2005;22(12):3241-3254. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2005.04488.x\">10.1111/j.1460-9568.2005.04488.x</a>"},"page":"3241 - 3254","publisher":"Wiley-Blackwell","intvolume":"        22","abstract":[{"lang":"eng","text":"Enhanced glutamatergic neurotransmission via the subthalamopallidal or subthalamonigral projection seems crucial for developing parkinsonian motor signs. In the present study, the possible changes in the expression of metabotropic glutamate receptors (mGluRs) were examined in the basal ganglia of a primate model for Parkinson's disease. When the patterns of immunohistochemical localization of mGluRs in monkeys administered systemically with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were analysed in comparison with normal controls, we found that expression of mGluR1α, but not of other subtypes, was significantly reduced in the internal and external segments of the globus pallidus and the substantia nigra pars reticulata. To elucidate the functional role of mGluR1 in the control of pallidal neuron activity, extracellular unit recordings combined with intrapallidal microinjections of mGluR1-related agents were then performed in normal and parkinsonian monkeys. In normal awake conditions, the spontaneous firing rates of neurons in the pallidal complex were increased by DHPG, a selective agonist of group I mGluRs, whereas they were decreased by AIDA, a selective antagonist of group I mGluRs, or LY367385, a selective antagonist of mGluR1. These electrophysiological data strongly indicate that the excitatory mechanism of pallidal neurons by glutamate is mediated at least partly through mGluR1. The effects of the mGluR1-related agents on neuronal firing in the internal pallidal segment became rather obscure after MPTP treatment. Our results suggest that the specific down-regulation of pallidal and nigral mGluR1 ot in the parkinsonian state may exert a compensatory action to reverse the overactivity of the subthalamic nucleus-derived glutamatergic input that is generated in the disease."}],"date_updated":"2021-01-12T06:58:52Z","type":"journal_article","author":[{"last_name":"Kaneda","full_name":"Kaneda, Katsuyuki","first_name":"Katsuyuki"},{"full_name":"Tachibana, Yoshihisa","first_name":"Yoshihisa","last_name":"Tachibana"},{"last_name":"Imanishi","full_name":"Imanishi, Michiko","first_name":"Michiko"},{"first_name":"Hitoshi","full_name":"Kita, Hitoshi","last_name":"Kita"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"first_name":"Atsushi","full_name":"Nambu, Atsushi","last_name":"Nambu"},{"last_name":"Takada","first_name":"Masahiko","full_name":"Takada, Masahiko"}],"year":"2005","extern":1,"date_created":"2018-12-11T11:58:55Z","issue":"12"},{"citation":{"ama":"Erdös L, Hasler D, Solovej J. Existence of the D0-D4 bound state: A detailed proof. <i>Annales Henri Poincare</i>. 2005;6(2):247-267. doi:<a href=\"https://doi.org/10.1007/s00023-005-0205-0\">10.1007/s00023-005-0205-0</a>","short":"L. Erdös, D. Hasler, J. Solovej, Annales Henri Poincare 6 (2005) 247–267.","apa":"Erdös, L., Hasler, D., &#38; Solovej, J. (2005). Existence of the D0-D4 bound state: A detailed proof. <i>Annales Henri Poincare</i>. Birkhäuser. <a href=\"https://doi.org/10.1007/s00023-005-0205-0\">https://doi.org/10.1007/s00023-005-0205-0</a>","ieee":"L. Erdös, D. Hasler, and J. Solovej, “Existence of the D0-D4 bound state: A detailed proof,” <i>Annales Henri Poincare</i>, vol. 6, no. 2. Birkhäuser, pp. 247–267, 2005.","chicago":"Erdös, László, David Hasler, and Jan Solovej. “Existence of the D0-D4 Bound State: A Detailed Proof.” <i>Annales Henri Poincare</i>. Birkhäuser, 2005. <a href=\"https://doi.org/10.1007/s00023-005-0205-0\">https://doi.org/10.1007/s00023-005-0205-0</a>.","mla":"Erdös, László, et al. “Existence of the D0-D4 Bound State: A Detailed Proof.” <i>Annales Henri Poincare</i>, vol. 6, no. 2, Birkhäuser, 2005, pp. 247–67, doi:<a href=\"https://doi.org/10.1007/s00023-005-0205-0\">10.1007/s00023-005-0205-0</a>.","ista":"Erdös L, Hasler D, Solovej J. 2005. Existence of the D0-D4 bound state: A detailed proof. Annales Henri Poincare. 6(2), 247–267."},"page":"247 - 267","intvolume":"         6","publisher":"Birkhäuser","author":[{"orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László","full_name":"László Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hasler","full_name":"Hasler, David G","first_name":"David"},{"first_name":"Jan","full_name":"Solovej, Jan P","last_name":"Solovej"}],"year":"2005","abstract":[{"text":"We consider the supersymmetric quantum mechanical system which is obtained by dimensionally reducing d = 6, N = 1 supersymmetric gauge theory with gauge group U(1) and a single charged hypermultiplet. Using the deformation method and ideas introduced by Porrati and Rozenberg [1], we present a detailed proof of the existence of a normalizable ground state for this system.","lang":"eng"}],"date_updated":"2021-01-12T06:59:24Z","type":"journal_article","date_created":"2018-12-11T11:59:22Z","extern":1,"issue":"2","volume":6,"title":"Existence of the D0-D4 bound state: A detailed proof","publication":"Annales Henri Poincare","status":"public","_id":"2743","date_published":"2005-04-01T00:00:00Z","doi":"10.1007/s00023-005-0205-0","day":"01","month":"04","quality_controlled":0,"publication_status":"published","publist_id":"4149"},{"citation":{"ista":"Eng D, Erdös L. 2005. The linear Boltzmann equation as the low density limit of a random Schrödinger equation. Reviews in Mathematical Physics. 17(6), 669–743.","mla":"Eng, David, and László Erdös. “The Linear Boltzmann Equation as the Low Density Limit of a Random Schrödinger Equation.” <i>Reviews in Mathematical Physics</i>, vol. 17, no. 6, World Scientific Publishing, 2005, pp. 669–743, doi:<a href=\"https://doi.org/10.1142/S0129055X0500242X\">10.1142/S0129055X0500242X</a>.","chicago":"Eng, David, and László Erdös. “The Linear Boltzmann Equation as the Low Density Limit of a Random Schrödinger Equation.” <i>Reviews in Mathematical Physics</i>. World Scientific Publishing, 2005. <a href=\"https://doi.org/10.1142/S0129055X0500242X\">https://doi.org/10.1142/S0129055X0500242X</a>.","ieee":"D. Eng and L. Erdös, “The linear Boltzmann equation as the low density limit of a random Schrödinger equation,” <i>Reviews in Mathematical Physics</i>, vol. 17, no. 6. World Scientific Publishing, pp. 669–743, 2005.","apa":"Eng, D., &#38; Erdös, L. (2005). The linear Boltzmann equation as the low density limit of a random Schrödinger equation. <i>Reviews in Mathematical Physics</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/S0129055X0500242X\">https://doi.org/10.1142/S0129055X0500242X</a>","short":"D. Eng, L. Erdös, Reviews in Mathematical Physics 17 (2005) 669–743.","ama":"Eng D, Erdös L. The linear Boltzmann equation as the low density limit of a random Schrödinger equation. <i>Reviews in Mathematical Physics</i>. 2005;17(6):669-743. doi:<a href=\"https://doi.org/10.1142/S0129055X0500242X\">10.1142/S0129055X0500242X</a>"},"page":"669 - 743","intvolume":"        17","publisher":"World Scientific Publishing","author":[{"last_name":"Eng","first_name":"David","full_name":"Eng, David"},{"last_name":"Erdös","orcid":"0000-0001-5366-9603","first_name":"László","full_name":"László Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"}],"year":"2005","type":"journal_article","date_updated":"2021-01-12T06:59:25Z","abstract":[{"text":"We study the long time evolution of a quantum particle interacting with a random potential in the Boltzmann-Grad low density limit. We prove that the phase space density of the quantum evolution defined through the Husimi function converges weakly to a linear Boltzmann equation. The Boltzmann collision kernel is given by the full quantum scattering cross-section of the obstacle potential.","lang":"eng"}],"date_created":"2018-12-11T11:59:22Z","extern":1,"issue":"6","volume":17,"title":"The linear Boltzmann equation as the low density limit of a random Schrödinger equation","publication":"Reviews in Mathematical Physics","status":"public","date_published":"2005-07-01T00:00:00Z","_id":"2744","doi":"10.1142/S0129055X0500242X","day":"01","month":"07","quality_controlled":0,"publication_status":"published","publist_id":"4148"},{"_id":"2788","date_published":"2005-11-17T00:00:00Z","doi":"10.1103/PhysRevLett.95.214502","volume":95,"publication":"Physical Review Letters","title":"Turbulence regeneration in pipe flow at moderate reynolds numbers","status":"public","month":"11","quality_controlled":0,"publist_id":"4101","publication_status":"published","day":"17","intvolume":"        95","publisher":"American Physical Society","year":"2005","author":[{"orcid":"0000-0003-2057-2754","last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87","first_name":"Björn","full_name":"Björn Hof"},{"last_name":"Van Doorne","first_name":"Casimir","full_name":"van Doorne, Casimir W"},{"last_name":"Westerweel","first_name":"Jerry","full_name":"Westerweel, Jerry"},{"full_name":"Nieuwstadt, Frans T","first_name":"Frans","last_name":"Nieuwstadt"}],"abstract":[{"lang":"eng","text":"We present the results of an experimental investigation into the nature and structure of turbulent pipe flow at moderate Reynolds numbers. A turbulence regeneration mechanism is identified which sustains a symmetric traveling wave within the flow. The periodicity of the mechanism allows comparison to the wavelength of numerically observed exact traveling wave solutions and close agreement is found. The advection speed of the upstream turbulence laminar interface in the experimental flow is observed to form a lower bound on the phase velocities of the exact traveling wave solutions. Overall our observations suggest that the dynamics of the turbulent flow at moderate Reynolds numbers are governed by unstable nonlinear traveling waves."}],"date_updated":"2021-01-12T06:59:43Z","type":"journal_article","citation":{"ieee":"B. Hof, C. Van Doorne, J. Westerweel, and F. Nieuwstadt, “Turbulence regeneration in pipe flow at moderate reynolds numbers,” <i>Physical Review Letters</i>, vol. 95, no. 21. American Physical Society, 2005.","chicago":"Hof, Björn, Casimir Van Doorne, Jerry Westerweel, and Frans Nieuwstadt. “Turbulence Regeneration in Pipe Flow at Moderate Reynolds Numbers.” <i>Physical Review Letters</i>. American Physical Society, 2005. <a href=\"https://doi.org/10.1103/PhysRevLett.95.214502\">https://doi.org/10.1103/PhysRevLett.95.214502</a>.","ista":"Hof B, Van Doorne C, Westerweel J, Nieuwstadt F. 2005. Turbulence regeneration in pipe flow at moderate reynolds numbers. Physical Review Letters. 95(21).","mla":"Hof, Björn, et al. “Turbulence Regeneration in Pipe Flow at Moderate Reynolds Numbers.” <i>Physical Review Letters</i>, vol. 95, no. 21, American Physical Society, 2005, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.95.214502\">10.1103/PhysRevLett.95.214502</a>.","apa":"Hof, B., Van Doorne, C., Westerweel, J., &#38; Nieuwstadt, F. (2005). Turbulence regeneration in pipe flow at moderate reynolds numbers. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.95.214502\">https://doi.org/10.1103/PhysRevLett.95.214502</a>","ama":"Hof B, Van Doorne C, Westerweel J, Nieuwstadt F. Turbulence regeneration in pipe flow at moderate reynolds numbers. <i>Physical Review Letters</i>. 2005;95(21). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.95.214502\">10.1103/PhysRevLett.95.214502</a>","short":"B. Hof, C. Van Doorne, J. Westerweel, F. Nieuwstadt, Physical Review Letters 95 (2005)."},"issue":"21","date_created":"2018-12-11T11:59:36Z","extern":1},{"page":"221 - 231","citation":{"ista":"Hof B. 2005. Transition to turbulence in pipe flow. Fluid Mechanics and its Applications. 77, 221–231.","mla":"Hof, Björn. “Transition to Turbulence in Pipe Flow.” <i>Fluid Mechanics and Its Applications</i>, vol. 77, Springer, 2005, pp. 221–31, doi:<a href=\"https://doi.org/10.1007/1-4020-4049-0_12\">10.1007/1-4020-4049-0_12</a>.","ieee":"B. Hof, “Transition to turbulence in pipe flow,” <i>Fluid Mechanics and its Applications</i>, vol. 77. Springer, pp. 221–231, 2005.","chicago":"Hof, Björn. “Transition to Turbulence in Pipe Flow.” <i>Fluid Mechanics and Its Applications</i>. Springer, 2005. <a href=\"https://doi.org/10.1007/1-4020-4049-0_12\">https://doi.org/10.1007/1-4020-4049-0_12</a>.","short":"B. Hof, Fluid Mechanics and Its Applications 77 (2005) 221–231.","ama":"Hof B. Transition to turbulence in pipe flow. <i>Fluid Mechanics and its Applications</i>. 2005;77:221-231. doi:<a href=\"https://doi.org/10.1007/1-4020-4049-0_12\">10.1007/1-4020-4049-0_12</a>","apa":"Hof, B. (2005). Transition to turbulence in pipe flow. <i>Fluid Mechanics and Its Applications</i>. Springer. <a href=\"https://doi.org/10.1007/1-4020-4049-0_12\">https://doi.org/10.1007/1-4020-4049-0_12</a>"},"type":"journal_article","abstract":[{"text":"Transitional pipe flow is investigated in two different experimental set-ups. In the first the stability threshold and the initial growth of localized perturbations are studied. Good agreement is found with an earlier investigation of the transition threshold. The measurement technique applied in the last part of this study allows the reconstruction of the streamwise vorticity in a turbulent puff.","lang":"eng"}],"date_updated":"2021-01-12T06:59:43Z","year":"2005","author":[{"full_name":"Björn Hof","first_name":"Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","last_name":"Hof","orcid":"0000-0003-2057-2754"}],"publisher":"Springer","intvolume":"        77","date_created":"2018-12-11T11:59:36Z","extern":1,"status":"public","title":"Transition to turbulence in pipe flow","publication":"Fluid Mechanics and its Applications","volume":77,"doi":"10.1007/1-4020-4049-0_12","date_published":"2005-09-19T00:00:00Z","_id":"2789","day":"19","publist_id":"4100","publication_status":"published","quality_controlled":0,"month":"09"},{"extern":1,"date_created":"2018-12-11T11:59:37Z","page":"193 - 201","citation":{"ama":"Hof B, Juel A, Mullin T. Magnetohydrodynamic damping of oscillations in low-Prandtl-number convection. <i>Journal of Fluid Mechanics</i>. 2005;545:193-201. doi:<a href=\"https://doi.org/10.1017/S0022112005006762\">10.1017/S0022112005006762</a>","short":"B. Hof, A. Juel, T. Mullin, Journal of Fluid Mechanics 545 (2005) 193–201.","apa":"Hof, B., Juel, A., &#38; Mullin, T. (2005). Magnetohydrodynamic damping of oscillations in low-Prandtl-number convection. <i>Journal of Fluid Mechanics</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0022112005006762\">https://doi.org/10.1017/S0022112005006762</a>","ieee":"B. Hof, A. Juel, and T. Mullin, “Magnetohydrodynamic damping of oscillations in low-Prandtl-number convection,” <i>Journal of Fluid Mechanics</i>, vol. 545. Cambridge University Press, pp. 193–201, 2005.","chicago":"Hof, Björn, Anne Juel, and Tom Mullin. “Magnetohydrodynamic Damping of Oscillations in Low-Prandtl-Number Convection.” <i>Journal of Fluid Mechanics</i>. Cambridge University Press, 2005. <a href=\"https://doi.org/10.1017/S0022112005006762\">https://doi.org/10.1017/S0022112005006762</a>.","ista":"Hof B, Juel A, Mullin T. 2005. Magnetohydrodynamic damping of oscillations in low-Prandtl-number convection. Journal of Fluid Mechanics. 545, 193–201.","mla":"Hof, Björn, et al. “Magnetohydrodynamic Damping of Oscillations in Low-Prandtl-Number Convection.” <i>Journal of Fluid Mechanics</i>, vol. 545, Cambridge University Press, 2005, pp. 193–201, doi:<a href=\"https://doi.org/10.1017/S0022112005006762\">10.1017/S0022112005006762</a>."},"author":[{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Björn Hof","first_name":"Björn","last_name":"Hof","orcid":"0000-0003-2057-2754"},{"last_name":"Juel","first_name":"Anne","full_name":"Juel, Anne"},{"full_name":"Mullin, Tom P","first_name":"Tom","last_name":"Mullin"}],"year":"2005","date_updated":"2021-01-12T06:59:44Z","type":"journal_article","abstract":[{"text":"We present the results of an experimental investigation of the effect of a magnetic field on the stability of convection in a liquid metal. A rectangular container of gallium is subjected to a horizontal temperature gradient and a uniform magnetic field is applied separately in three directions. The magnetic field suppresses the oscillation most effectively when it is applied in the vertical direction and is least efficient when applied in the direction of the temperature gradient. The critical temperature difference required for the onset of oscillations is found to scale exponentially with the magnitude of the magnetic field for all three orientations. Comparisons are made with available theory and qualitative differences are discussed.","lang":"eng"}],"intvolume":"       545","publisher":"Cambridge University Press","day":"25","publist_id":"4099","publication_status":"published","month":"12","quality_controlled":0,"status":"public","volume":545,"publication":"Journal of Fluid Mechanics","title":"Magnetohydrodynamic damping of oscillations in low-Prandtl-number convection","date_published":"2005-12-25T00:00:00Z","_id":"2790","doi":"10.1017/S0022112005006762"},{"issue":"10","extern":1,"date_created":"2018-12-11T12:00:01Z","intvolume":"        24","publisher":"Wiley-Blackwell","year":"2005","author":[{"last_name":"Weijers","first_name":"Dolf","full_name":"Weijers, Dolf"},{"first_name":"Eva","full_name":"Eva Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","last_name":"Benková"},{"last_name":"Jäger","full_name":"Jäger, Katja E","first_name":"Katja"},{"last_name":"Schlereth","first_name":"Alexandra","full_name":"Schlereth, Alexandra"},{"first_name":"Thorsten","full_name":"Hamann, Thorsten","last_name":"Hamann"},{"last_name":"Kientz","first_name":"Marika","full_name":"Kientz, Marika"},{"last_name":"Wilmoth","first_name":"Jill","full_name":"Wilmoth, Jill C"},{"full_name":"Reed, Jason W","first_name":"Jason","last_name":"Reed"},{"first_name":"Gerd","full_name":"Jürgens, Gerd","last_name":"Jürgens"}],"type":"journal_article","date_updated":"2021-01-12T07:00:22Z","abstract":[{"text":"The plant hormone auxin elicits many specific context-dependent developmental responses. Auxin promotes degradation of Aux/IAA proteins that prevent transcription factors of the auxin response factor (ARF) family from regulating auxin-responsive target genes. Aux/IAAs and ARFs are represented by large gene families in Arabidopsis. Here we show that stabilization of BDL/IAA12 or its sister protein IAA13 prevents MP/ARF5-dependent embryonic root formation whereas stabilized SHY2/IAA3 interferes with seedling growth. Although both bdl and shy2-2 proteins inhibited MP/ARF5-dependent reporter gene activation, shy2-2 was much less efficient than bdl to interfere with embryonic root initiation when expressed from the BDL promoter. Similarly, MP was much more efficient than ARF16 in this process. When expressed from the SHY2 promoter, both shy2-2 and bdl inhibited cell elongation and auxin-induced gene expression in the seedling hypocotyl. By contrast, gravitropism and auxin-induced gene expression in the root, which were promoted by functionally redundant NPH4/ARF7 and ARF19 proteins, were inhibited by shy2-2, but not by bdl protein. Our results suggest that auxin signals are converted into specific responses by matching pairs of coexpressed ARF and Aux/IAA proteins.","lang":"eng"}],"citation":{"short":"D. Weijers, E. Benková, K. Jäger, A. Schlereth, T. Hamann, M. Kientz, J. Wilmoth, J. Reed, G. Jürgens, EMBO Journal 24 (2005) 1874–1885.","ama":"Weijers D, Benková E, Jäger K, et al. Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators. <i>EMBO Journal</i>. 2005;24(10):1874-1885. doi:<a href=\"https://doi.org/10.1038/sj.emboj.7600659\">10.1038/sj.emboj.7600659</a>","apa":"Weijers, D., Benková, E., Jäger, K., Schlereth, A., Hamann, T., Kientz, M., … Jürgens, G. (2005). Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators. <i>EMBO Journal</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1038/sj.emboj.7600659\">https://doi.org/10.1038/sj.emboj.7600659</a>","mla":"Weijers, Dolf, et al. “Developmental Specificity of Auxin Response by Pairs of ARF and Aux/IAA Transcriptional Regulators.” <i>EMBO Journal</i>, vol. 24, no. 10, Wiley-Blackwell, 2005, pp. 1874–85, doi:<a href=\"https://doi.org/10.1038/sj.emboj.7600659\">10.1038/sj.emboj.7600659</a>.","ista":"Weijers D, Benková E, Jäger K, Schlereth A, Hamann T, Kientz M, Wilmoth J, Reed J, Jürgens G. 2005. Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators. EMBO Journal. 24(10), 1874–1885.","ieee":"D. Weijers <i>et al.</i>, “Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators,” <i>EMBO Journal</i>, vol. 24, no. 10. Wiley-Blackwell, pp. 1874–1885, 2005.","chicago":"Weijers, Dolf, Eva Benková, Katja Jäger, Alexandra Schlereth, Thorsten Hamann, Marika Kientz, Jill Wilmoth, Jason Reed, and Gerd Jürgens. “Developmental Specificity of Auxin Response by Pairs of ARF and Aux/IAA Transcriptional Regulators.” <i>EMBO Journal</i>. Wiley-Blackwell, 2005. <a href=\"https://doi.org/10.1038/sj.emboj.7600659\">https://doi.org/10.1038/sj.emboj.7600659</a>."},"page":"1874 - 1885","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142592/","open_access":"1"}],"month":"05","quality_controlled":0,"publication_status":"published","publist_id":"3918","day":"18","_id":"2867","date_published":"2005-05-18T00:00:00Z","oa":1,"doi":"10.1038/sj.emboj.7600659","volume":24,"title":"Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators","publication":"EMBO Journal","status":"public"},{"publist_id":"3863","publication_status":"published","month":"12","quality_controlled":0,"day":"01","_id":"2895","date_published":"2005-12-01T00:00:00Z","doi":"10.1016/j.cam.2004.10.025","acknowledgement":"The work was financially supported by Fundação para a Ciência e Tecnologia: grants  P/BIA/10094/1998,  POCTI/36413/99,  and  POCTI/MGI/46477/2002; and fellowships to JF (Praxis/BCC/18972/98), JS (BD/13546/97), KL (SFRH/BPD+/1157/2002), DM (SFRH/BD/2960/2000) and TP (SFRH/BD/10550/2002).","status":"public","volume":184,"title":"Immunological self tolerance: Lessons from mathematical modeling","publication":"Journal of Computational and Applied Mathematics","issue":"1","extern":1,"date_created":"2018-12-11T12:00:12Z","year":"2005","author":[{"last_name":"Carneiro","full_name":"Carneiro, Jorge","first_name":"Jorge"},{"first_name":"Tiago","full_name":"Tiago Paixao","id":"2C5658E6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2361-3953","last_name":"Paixao"},{"full_name":"Milutinovic, Dejan","first_name":"Dejan","last_name":"Milutinovic"},{"last_name":"Sousa","full_name":"Sousa, João","first_name":"João"},{"first_name":"Kalet","full_name":"Leon, Kalet","last_name":"Leon"},{"last_name":"Gardner","full_name":"Gardner, Rui","first_name":"Rui"},{"full_name":"Faro, Jose","first_name":"Jose","last_name":"Faro"}],"type":"journal_article","date_updated":"2021-01-12T07:00:32Z","abstract":[{"lang":"eng","text":"One of the fundamental properties of the immune system is its capacity to avoid autoimmune diseases. The mechanism underlying this process, known as self-tolerance, is hitherto unresolved but seems to involve the control of clonal expansion of autoreactive lymphocytes. This article reviews mathematical modeling of self-tolerance, addressing two specific hypotheses. The first hypothesis posits that self-tolerance is mediated by tuning of activation thresholds, which makes autoreactive T lymphocytes reversibly &quot;anergic&quot; and unable to proliferate. The second hypothesis posits that the proliferation of autoreactive T lymphocytes is instead controlled by specific regulatory T lymphocytes. Models representing the population dynamics of autoreactive T lymphocytes according to these two hypotheses were derived. For each model we identified how cell density affects tolerance, and predicted the corresponding phase spaces and bifurcations. We show that the simple induction of proliferative anergy, as modeled here, has a density dependence that is only partially compatible with adoptive transfers of tolerance, and that the models of tolerance mediated by specific regulatory T cells are closer to the observations."}],"intvolume":"       184","publisher":"Elsevier","page":"77 - 100","citation":{"ama":"Carneiro J, Paixao T, Milutinovic D, et al. Immunological self tolerance: Lessons from mathematical modeling. <i>Journal of Computational and Applied Mathematics</i>. 2005;184(1):77-100. doi:<a href=\"https://doi.org/10.1016/j.cam.2004.10.025\">10.1016/j.cam.2004.10.025</a>","short":"J. Carneiro, T. Paixao, D. Milutinovic, J. Sousa, K. Leon, R. Gardner, J. Faro, Journal of Computational and Applied Mathematics 184 (2005) 77–100.","apa":"Carneiro, J., Paixao, T., Milutinovic, D., Sousa, J., Leon, K., Gardner, R., &#38; Faro, J. (2005). Immunological self tolerance: Lessons from mathematical modeling. <i>Journal of Computational and Applied Mathematics</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cam.2004.10.025\">https://doi.org/10.1016/j.cam.2004.10.025</a>","chicago":"Carneiro, Jorge, Tiago Paixao, Dejan Milutinovic, João Sousa, Kalet Leon, Rui Gardner, and Jose Faro. “Immunological Self Tolerance: Lessons from Mathematical Modeling.” <i>Journal of Computational and Applied Mathematics</i>. Elsevier, 2005. <a href=\"https://doi.org/10.1016/j.cam.2004.10.025\">https://doi.org/10.1016/j.cam.2004.10.025</a>.","ieee":"J. Carneiro <i>et al.</i>, “Immunological self tolerance: Lessons from mathematical modeling,” <i>Journal of Computational and Applied Mathematics</i>, vol. 184, no. 1. Elsevier, pp. 77–100, 2005.","ista":"Carneiro J, Paixao T, Milutinovic D, Sousa J, Leon K, Gardner R, Faro J. 2005. Immunological self tolerance: Lessons from mathematical modeling. Journal of Computational and Applied Mathematics. 184(1), 77–100.","mla":"Carneiro, Jorge, et al. “Immunological Self Tolerance: Lessons from Mathematical Modeling.” <i>Journal of Computational and Applied Mathematics</i>, vol. 184, no. 1, Elsevier, 2005, pp. 77–100, doi:<a href=\"https://doi.org/10.1016/j.cam.2004.10.025\">10.1016/j.cam.2004.10.025</a>."}},{"publisher":"Springer","oa_version":"None","intvolume":"       226","type":"journal_article","abstract":[{"text":"In plants, cell polarity is an issue more recurring than in other systems, because plants, due to their adaptive and flexible development, often change cell polarity postembryonically according to intrinsic cues and demands of the environment. Recent findings on the directional movement of the plant signalling molecule auxin provide a unique connection between individual cell polarity and the establishment of polarity at the tissue, organ, and whole-plant levels. Decisions about the subcellular polar targeting of PIN auxin transport components determine the direction of auxin flow between cells and consequently mediate multiple developmental events. In addition, mutations or chemical interference with PIN-based auxin transport result in abnormal cell divisions. Thus, the complicated links between cell polarity establishment, auxin transport, cytoskeleton, and oriented cell divisions now begin to emerge. Here we review the available literature on the issues of cell polarity in both plants and animals to extend our understanding on the generation, maintenance, and transmission of cell polarity in plants.","lang":"eng"}],"date_updated":"2021-01-12T07:40:22Z","year":"2005","author":[{"first_name":"Pankaj","full_name":"Dhonukshe, Pankaj","last_name":"Dhonukshe"},{"last_name":"Kleine Vehn","full_name":"Kleine Vehn, Jürgen","first_name":"Jürgen"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","first_name":"Jirí"}],"citation":{"mla":"Dhonukshe, Pankaj, et al. “Cell Polarity, Auxin Transport and Cytoskeleton Mediated Division Planes: Who Comes First?” <i>Protoplasma</i>, vol. 226, no. 1–2, Springer, 2005, pp. 67–73, doi:<a href=\"https://doi.org/10.1007/s00709-005-0104-8\">10.1007/s00709-005-0104-8</a>.","ista":"Dhonukshe P, Kleine Vehn J, Friml J. 2005. Cell polarity, auxin transport and cytoskeleton mediated division planes: Who comes first? Protoplasma. 226(1–2), 67–73.","ieee":"P. Dhonukshe, J. Kleine Vehn, and J. Friml, “Cell polarity, auxin transport and cytoskeleton mediated division planes: Who comes first?,” <i>Protoplasma</i>, vol. 226, no. 1–2. Springer, pp. 67–73, 2005.","chicago":"Dhonukshe, Pankaj, Jürgen Kleine Vehn, and Jiří Friml. “Cell Polarity, Auxin Transport and Cytoskeleton Mediated Division Planes: Who Comes First?” <i>Protoplasma</i>. Springer, 2005. <a href=\"https://doi.org/10.1007/s00709-005-0104-8\">https://doi.org/10.1007/s00709-005-0104-8</a>.","apa":"Dhonukshe, P., Kleine Vehn, J., &#38; Friml, J. (2005). Cell polarity, auxin transport and cytoskeleton mediated division planes: Who comes first? <i>Protoplasma</i>. Springer. <a href=\"https://doi.org/10.1007/s00709-005-0104-8\">https://doi.org/10.1007/s00709-005-0104-8</a>","short":"P. Dhonukshe, J. Kleine Vehn, J. Friml, Protoplasma 226 (2005) 67–73.","ama":"Dhonukshe P, Kleine Vehn J, Friml J. Cell polarity, auxin transport and cytoskeleton mediated division planes: Who comes first? <i>Protoplasma</i>. 2005;226(1-2):67-73. doi:<a href=\"https://doi.org/10.1007/s00709-005-0104-8\">10.1007/s00709-005-0104-8</a>"},"page":"67 - 73","issue":"1-2","date_created":"2018-12-11T12:00:47Z","extern":"1","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","doi":"10.1007/s00709-005-0104-8","date_published":"2005-10-01T00:00:00Z","_id":"3000","publication":"Protoplasma","title":"Cell polarity, auxin transport and cytoskeleton mediated division planes: Who comes first?","volume":226,"status":"public","language":[{"iso":"eng"}],"quality_controlled":"1","month":"10","publist_id":"3701","publication_status":"published","day":"01"},{"issue":"7046","extern":1,"date_created":"2018-12-11T12:00:47Z","intvolume":"       435","publisher":"Nature Publishing Group","year":"2005","author":[{"first_name":"Tomasz","full_name":"Paciorek, Tomasz","last_name":"Paciorek"},{"last_name":"Zažímalová","first_name":"Eva","full_name":"Zažímalová, Eva"},{"last_name":"Ruthardt","full_name":"Ruthardt, Nadia","first_name":"Nadia"},{"last_name":"Petrášek","first_name":"Jan","full_name":"Petrášek, Jan"},{"last_name":"Stierhof","first_name":"York","full_name":"Stierhof, York-Dieter"},{"full_name":"Kleine-Vehn, Jürgen","first_name":"Jürgen","last_name":"Kleine Vehn"},{"full_name":"Morris, David A","first_name":"David","last_name":"Morris"},{"last_name":"Emans","full_name":"Emans, Neil","first_name":"Neil"},{"last_name":"Jürgens","full_name":"Jürgens, Gerd","first_name":"Gerd"},{"first_name":"Niko","full_name":"Geldner, Niko","last_name":"Geldner"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí","full_name":"Jirí Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2021-01-12T07:40:23Z","abstract":[{"lang":"eng","text":"One of the mechanisms by which signalling molecules regulate cellular behaviour is modulating subcellular protein translocation. This mode of regulation is often based on specialized vesicle trafficking, termed constitutive cycling, which consists of repeated internalization and recycling of proteins to and from the plasma membrane. No such mechanism of hormone action has been shown in plants although several proteins, including the PIN auxin efflux facilitators, exhibit constitutive cycling. Here we show that a major regulator of plant development, auxin, inhibits endocytosis. This effect is specific to biologically active auxins and requires activity of the Calossin-like protein BIG. By inhibiting the internalization step of PIN constitutive cycling, auxin increases levels of PINs at the plasma membrane. Concomitantly, auxin promotes its own efflux from cells by a vesicle-trafficking-dependent mechanism. Furthermore, asymmetric auxin translocation during gravitropism is correlated with decreased PIN internalization. Our data imply a previously undescribed mode of plant hormone action: by modulating PIN protein trafficking, auxin regulates PIN abundance and activity at the cell surface, providing a mechanism for the feedback regulation of auxin transport."}],"type":"journal_article","citation":{"mla":"Paciorek, Tomasz, et al. “Auxin Inhibits Endocytosis and Promotes Its Own Efflux from Cells.” <i>Nature</i>, vol. 435, no. 7046, Nature Publishing Group, 2005, pp. 1251–56, doi:<a href=\"https://doi.org/10.1038/nature03633\">10.1038/nature03633</a>.","ista":"Paciorek T, Zažímalová E, Ruthardt N, Petrášek J, Stierhof Y, Kleine Vehn J, Morris D, Emans N, Jürgens G, Geldner N, Friml J. 2005. Auxin inhibits endocytosis and promotes its own efflux from cells. Nature. 435(7046), 1251–1256.","chicago":"Paciorek, Tomasz, Eva Zažímalová, Nadia Ruthardt, Jan Petrášek, York Stierhof, Jürgen Kleine Vehn, David Morris, et al. “Auxin Inhibits Endocytosis and Promotes Its Own Efflux from Cells.” <i>Nature</i>. Nature Publishing Group, 2005. <a href=\"https://doi.org/10.1038/nature03633\">https://doi.org/10.1038/nature03633</a>.","ieee":"T. Paciorek <i>et al.</i>, “Auxin inhibits endocytosis and promotes its own efflux from cells,” <i>Nature</i>, vol. 435, no. 7046. Nature Publishing Group, pp. 1251–1256, 2005.","apa":"Paciorek, T., Zažímalová, E., Ruthardt, N., Petrášek, J., Stierhof, Y., Kleine Vehn, J., … Friml, J. (2005). Auxin inhibits endocytosis and promotes its own efflux from cells. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature03633\">https://doi.org/10.1038/nature03633</a>","short":"T. Paciorek, E. Zažímalová, N. Ruthardt, J. Petrášek, Y. Stierhof, J. Kleine Vehn, D. Morris, N. Emans, G. Jürgens, N. Geldner, J. Friml, Nature 435 (2005) 1251–1256.","ama":"Paciorek T, Zažímalová E, Ruthardt N, et al. Auxin inhibits endocytosis and promotes its own efflux from cells. <i>Nature</i>. 2005;435(7046):1251-1256. doi:<a href=\"https://doi.org/10.1038/nature03633\">10.1038/nature03633</a>"},"page":"1251 - 1256","month":"06","quality_controlled":0,"publication_status":"published","publist_id":"3702","day":"30","_id":"3001","date_published":"2005-06-30T00:00:00Z","doi":"10.1038/nature03633","volume":435,"title":"Auxin inhibits endocytosis and promotes its own efflux from cells","publication":"Nature","status":"public"}]