[{"acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"file_date_updated":"2026-02-17T10:16:57Z","corr_author":"1","citation":{"short":"L.M. Becker, P. Schanda, (2025).","chicago":"Becker, Lea Marie, and Paul Schanda. “Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20641.","ista":"Becker LM, Schanda P. 2025. Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes’, Institute of Science and Technology Austria, 10.15479/AT-ISTA-20641.","apa":"Becker, L. M., & Schanda, P. (2025). Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20641","ieee":"L. M. Becker and P. Schanda, “Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2025.","ama":"Becker LM, Schanda P. Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” 2025. doi:10.15479/AT-ISTA-20641","mla":"Becker, Lea Marie, and Paul Schanda. Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20641."},"status":"public","year":"2025","date_published":"2025-11-18T00:00:00Z","has_accepted_license":"1","author":[{"last_name":"Becker","first_name":"Lea Marie","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","full_name":"Becker, Lea Marie","orcid":"0000-0002-6401-5151"},{"last_name":"Schanda","first_name":"Paul","orcid":"0000-0002-9350-7606","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul"}],"file":[{"access_level":"open_access","date_updated":"2026-02-17T10:16:57Z","file_id":"20643","date_created":"2025-11-13T09:38:35Z","file_name":"Research_Data.zip","file_size":1806589513,"creator":"lbecker","checksum":"a73a0550c644957e7f62241e239d3a1d","content_type":"application/zip","relation":"main_file"},{"relation":"table_of_contents","content_type":"application/pdf","checksum":"7176b257f753c213a0460ee06f802363","creator":"lbecker","file_size":191376,"file_name":"README.pdf","date_created":"2025-11-17T11:54:17Z","file_id":"20652","date_updated":"2026-02-17T10:16:57Z","access_level":"open_access"}],"abstract":[{"lang":"eng","text":"Protein conformational energy landscapes are shaped not only by intramolecular interactions but also by their environment. In protein crystals and protein-protein complexes, intermolecular contacts alter this energy landscape, but the exact nature of this alteration is difficult to decipher. Understanding how the crystal lattice affects protein dynamics is crucial for crystallography-based studies of motion, yet its influence on collective motions remains unclear. Aromatic ring flips in the hydrophobic core represent sensitive probes of such dynamics. Here, we compare the kinetics of aromatic ring flips in the protein GB1 in crystals, in complex with its binding partner IgG, and in solution, combining advanced isotope labeling with quantitative NMR methods. We show that rings in the core flip nearly a thousand times less frequently in crystals than in solution. Enhanced-sampling molecular dynamics simulations, based on a new crystal structure, reproduce these elevated barriers and reveal how the crystal restrains motions. "}],"oa":1,"publisher":"Institute of Science and Technology Austria","related_material":{"record":[{"relation":"later_version","id":"21145","status":"public"}]},"title":"Data for \"Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes\"","acknowledgement":"We thank Nikolai R. Skrynnikov and Olga O. Lebedenko (St. Petersburg) for insightful discussions and for performing exploratory MD simulations. We are grateful to Tobias Schubeis (Lyon) for advice with GB1 crystallization, and Rebecca Schmid for initial crystallization trials.\r\nWe thank Sebastian Falkner for assistance with constructing the structural model of the IgG:GB1 complex.\r\nThis research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank Petra Rovó and Margarita Valhondo Falcón for excellent support of the NMR facility.\r\nLea M. Becker is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (grant no. PR10660EAW01). Christophe Chipot acknowledges the European Research Council (grant project 101097272 ``MilliInMicro'') and the Métropole du Grand Nancy (grant project ``ARC''). BM07-FIP2 is supported by the French ANR PIA3 (France 2030) EquipEx+ project MAGNIFIX under grant agreement ANR-21-ESRE-0011.","date_created":"2025-11-13T09:29:58Z","date_updated":"2026-06-10T08:25:17Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)"},"day":"18","doi":"10.15479/AT-ISTA-20641","_id":"20641","project":[{"grant_number":"26777","name":"Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches","_id":"7be609c4-9f16-11ee-852c-85015ce2b9b0"}],"contributor":[{"contributor_type":"researcher","first_name":"Haohao ","last_name":"Fu"},{"last_name":"Tatman","id":"71cda2f3-e604-11ee-a1df-da10587eda3f","first_name":"Benjamin","contributor_type":"researcher"},{"contributor_type":"researcher","first_name":"Matthias","last_name":"Dreydoppel"},{"contributor_type":"researcher","first_name":"Anna","id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471","last_name":"Kapitonova"},{"contributor_type":"researcher","first_name":"Daniel","orcid":"0000-0001-7597-043X","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","last_name":"Balazs"},{"contributor_type":"researcher","first_name":"Ulrich","last_name":"Weininger"},{"first_name":"Sylvain","last_name":"Engilberge","contributor_type":"researcher"},{"first_name":"Christophe","last_name":"Chipot","contributor_type":"researcher"}],"department":[{"_id":"GradSch"},{"_id":"PaSc"}],"ddc":["572"],"article_processing_charge":"No","month":"11","type":"research_data","oa_version":"Published Version"},{"publisher":"Institute of Science and Technology Austria","article_processing_charge":"No","file":[{"content_type":"application/octet-stream","relation":"main_file","checksum":"a2ef61aa9fb5313c7d426913eb0482c0","creator":"pschanda","file_name":"README","file_size":1160,"success":1,"date_created":"2025-07-03T10:30:14Z","file_id":"19960","access_level":"open_access","date_updated":"2025-07-03T10:30:14Z"},{"file_size":128597184,"file_name":"data_Arg_MASNMR_Rohden.zip","creator":"pschanda","checksum":"8fb77b96d0fcc95c9903005652207a8c","relation":"main_file","content_type":"application/zip","date_updated":"2025-07-03T10:30:55Z","access_level":"open_access","success":1,"date_created":"2025-07-03T10:30:55Z","file_id":"19961"},{"creator":"pschanda","file_name":"20240903_ubi_DN_Argd1C13_2D_spectra.tar.xz","file_size":4766564,"relation":"main_file","content_type":"application/x-xz","checksum":"a60cc16d20b089c4bef94040a99cfba5","date_updated":"2025-08-14T07:06:58Z","access_level":"open_access","file_id":"20172","date_created":"2025-08-14T07:06:58Z","success":1}],"abstract":[{"lang":"eng","text":"The specific introduction of 1H-13C or 1H-15N moieties into otherwise deuterated proteins holds great potential for high-resolution solution and magic-angle spinning (MAS) NMR studies of protein structure and dynamics. Arginine residues play key roles for example at active sites of enzymes. Taking advantage of a chemically synthesized Arg with a 13C-1H2 group in an otherwise deuterated backbone, we demonstrate here the usefulness of proton-detected arginine MAS NMR approaches to probe arginine dynamics. In experiments on crystalline ubiquitin and the 134 kDa tetrameric enzyme malate dehydrogenase we detected a wide range of motions, from sites that are rigid on time scales of at least tens of milliseconds to residues undergoing predominantly nanosecond motions. Spin-relaxation and dipolar-coupling measurements enabled quantitative determination of these dynamics. We observed microsecond dynamics of residue Arg54 in crystalline ubiquitin, whose backbone is known to sample different β-turn conformations on this time scale. The labeling scheme and experiments presented here expand the toolkit for high-resolution proton-detected MAS NMR"}],"department":[{"_id":"PaSc"}],"oa":1,"ddc":["572"],"user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","date_updated":"2026-06-10T08:20:38Z","type":"research_data","title":"Arginine Dynamics Probed by Magic-Angle Spinning NMR with a Specific Isotope-Labeling Scheme","related_material":{"record":[{"id":"20258","relation":"used_in_publication","status":"public"}]},"month":"07","date_created":"2025-07-03T04:21:37Z","oa_version":"Published Version","citation":{"short":"P. Schanda, (2025).","chicago":"Schanda, Paul. “Arginine Dynamics Probed by Magic-Angle Spinning NMR with a Specific Isotope-Labeling Scheme.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19956.","apa":"Schanda, P. (2025). Arginine Dynamics Probed by Magic-Angle Spinning NMR with a Specific Isotope-Labeling Scheme. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19956","ama":"Schanda P. Arginine Dynamics Probed by Magic-Angle Spinning NMR with a Specific Isotope-Labeling Scheme. 2025. doi:10.15479/AT-ISTA-19956","ieee":"P. Schanda, “Arginine Dynamics Probed by Magic-Angle Spinning NMR with a Specific Isotope-Labeling Scheme.” Institute of Science and Technology Austria, 2025.","ista":"Schanda P. 2025. Arginine Dynamics Probed by Magic-Angle Spinning NMR with a Specific Isotope-Labeling Scheme, Institute of Science and Technology Austria, 10.15479/AT-ISTA-19956.","mla":"Schanda, Paul. Arginine Dynamics Probed by Magic-Angle Spinning NMR with a Specific Isotope-Labeling Scheme. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19956."},"corr_author":"1","file_date_updated":"2025-08-14T07:06:58Z","_id":"19956","year":"2025","project":[{"name":"AlloSpace. The emergence and mechanisms of allostery","grant_number":"I05812","_id":"eb9c82eb-77a9-11ec-83b8-aadd536561cf"}],"date_published":"2025-07-03T00:00:00Z","status":"public","day":"03","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)"},"doi":"10.15479/AT-ISTA-19956","acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"author":[{"first_name":"Paul","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","last_name":"Schanda"}],"has_accepted_license":"1","contributor":[{"first_name":"Darja","last_name":"Rohden","contributor_type":"researcher"},{"contributor_type":"researcher","last_name":"Napoli","first_name":"Federico"},{"contributor_type":"researcher","first_name":"Ben","last_name":"Tatman"},{"contributor_type":"researcher","last_name":"Schanda","first_name":"Paul"}]},{"date_created":"2025-12-10T23:40:14Z","oa_version":"Published Version","month":"12","keyword":["Schizophora","sex chromosomes","sex-chromosome turnover","Diptera","genomic features","out-of-X movement."],"type":"research_data","title":"Causes and consequences of sex-chromosome turnovers in Diptera","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","date_updated":"2026-06-10T08:27:48Z","oa":1,"file":[{"access_level":"open_access","date_updated":"2025-12-11T10:47:15Z","file_id":"20799","date_created":"2025-12-11T10:47:15Z","success":1,"creator":"llayanaf","file_name":"Perl_scripts.zip","file_size":4575,"content_type":"application/zip","relation":"main_file","checksum":"251e7aab01917c2ad2fbccf465492ea1"},{"content_type":"application/zip","relation":"main_file","checksum":"daf1c03149dd170b14e5c8e109ee3c77","creator":"llayanaf","file_size":19052849,"file_name":"Supplementary_Datasets.zip","file_id":"20800","success":1,"date_created":"2025-12-11T10:52:17Z","date_updated":"2025-12-11T10:52:17Z","access_level":"open_access"},{"checksum":"658d6e95a361b0a3db058b7b4e1733d4","relation":"main_file","content_type":"application/zip","file_size":566476,"file_name":"Supplementary_Tables.zip","creator":"llayanaf","date_created":"2025-12-11T10:52:11Z","success":1,"file_id":"20801","date_updated":"2025-12-11T10:52:11Z","access_level":"open_access"},{"success":1,"file_id":"20802","date_created":"2025-12-11T11:00:53Z","date_updated":"2025-12-11T11:00:53Z","access_level":"open_access","checksum":"2a2b92eb9fade0015719190596a8c5b7","content_type":"text/plain","relation":"main_file","file_name":"README.txt","file_size":1204,"creator":"llayanaf"}],"department":[{"_id":"BeVi"}],"abstract":[{"lang":"eng","text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analysed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on the F element (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male-achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes."}],"article_processing_charge":"No","publisher":"Institute of Science and Technology Austria","has_accepted_license":"1","author":[{"last_name":"Layana Franco","first_name":"Lorena Alexandra","orcid":"0000-0002-1253-6297","full_name":"Layana Franco, Lorena Alexandra","id":"02814589-eb8f-11eb-b029-a70074f3f18f"},{"orcid":"0000-0002-9752-7380","full_name":"Toups, Melissa A","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","first_name":"Melissa A","last_name":"Toups"},{"first_name":"Beatriz","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso"}],"acknowledged_ssus":[{"_id":"ScienComp"}],"doi":"10.15479/AT-ISTA-20780","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"status":"public","year":"2025","_id":"20780","date_published":"2025-12-01T00:00:00Z","corr_author":"1","file_date_updated":"2025-12-11T11:00:53Z","citation":{"short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, (2025).","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20780.","ista":"Layana Franco LA, Toups MA, Vicoso B. 2025. Causes and consequences of sex-chromosome turnovers in Diptera, Institute of Science and Technology Austria, 10.15479/AT-ISTA-20780.","ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Causes and consequences of sex-chromosome turnovers in Diptera.” Institute of Science and Technology Austria, 2025.","ama":"Layana Franco LA, Toups MA, Vicoso B. Causes and consequences of sex-chromosome turnovers in Diptera. 2025. doi:10.15479/AT-ISTA-20780","apa":"Layana Franco, L. A., Toups, M. A., & Vicoso, B. (2025). Causes and consequences of sex-chromosome turnovers in Diptera. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20780","mla":"Layana Franco, Lorena Alexandra, et al. Causes and Consequences of Sex-Chromosome Turnovers in Diptera. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20780."}},{"oa":1,"abstract":[{"text":"Persistent revivals recently observed in Rydberg atom simulators have challenged our understanding of thermalization and attracted much interest to the concept of quantum many-body scars (QMBSs). QMBSs are non-thermal highly excited eigenstates that coexist with typical eigenstates in the spectrum of many-body Hamiltonians, and have since been reported in multiple theoretical models, including the so-called PXP model, approximately realized by Rydberg simulators. At the same time, questions of how common QMBSs are and in what models they are physically realized remain open. In this Letter, we demonstrate that QMBSs exist in a broader family of models that includes and generalizes PXP to longer-range constraints and states with different periodicity. We show that in each model, multiple QMBS families can be found. Each of them relies on a different approximate algebra, leading to oscillatory dynamics in all cases. However, in contrast to the PXP model, their observation requires launching dynamics from weakly entangled initial states rather than from a product state. QMBSs reported here may be experimentally probed using Rydberg atom simulator in the regime of longer-range Rydberg blockades.","lang":"eng"}],"file":[{"creator":"dernst","file_name":"2025_PhysReviewLetters_Kerschbaumer.pdf","file_size":1028993,"content_type":"application/pdf","relation":"main_file","checksum":"b7f581291e20f152d0efc64727314ca2","date_updated":"2025-05-12T07:33:38Z","access_level":"open_access","success":1,"date_created":"2025-05-12T07:33:38Z","file_id":"19677"}],"OA_place":"publisher","ec_funded":1,"publisher":"American Physical Society","date_created":"2025-05-11T22:02:38Z","acknowledgement":"The authors are grateful to Zlatko Papić, Dolev Bluvstein, Nishad Maskara, Marcello Dalmonte, Thomas Iadecola, and Johannes Feldmeier for insightful discussions. A. K., M. L., and M. S. acknowledge support by the European Research Council under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899). J.-Y. D. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 101034413.","title":"Quantum many-body scars beyond the PXP model in Rydberg simulators","related_material":{"link":[{"relation":"press_release","description":"News on ISTA website","url":"https://ista.ac.at/en/news/a-sky-full-of-quantum-scars/"}],"record":[{"status":"public","relation":"research_data","id":"19623"}]},"publication":"Physical Review Letters","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","pmid":1,"arxiv":1,"date_updated":"2026-06-10T08:40:51Z","quality_controlled":"1","language":[{"iso":"eng"}],"external_id":{"pmid":["40344113"],"arxiv":["2410.18913"],"isi":["001480669300011"]},"date_published":"2025-04-22T00:00:00Z","year":"2025","publication_status":"published","status":"public","file_date_updated":"2025-05-12T07:33:38Z","citation":{"chicago":"Kerschbaumer, Aron, Marko Ljubotina, Maksym Serbyn, and Jean-Yves Marc Desaules. “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” Physical Review Letters. American Physical Society, 2025. https://doi.org/10.1103/PhysRevLett.134.160401.","short":"A. Kerschbaumer, M. Ljubotina, M. Serbyn, J.-Y.M. Desaules, Physical Review Letters 134 (2025).","mla":"Kerschbaumer, Aron, et al. “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” Physical Review Letters, vol. 134, no. 16, 160401, American Physical Society, 2025, doi:10.1103/PhysRevLett.134.160401.","apa":"Kerschbaumer, A., Ljubotina, M., Serbyn, M., & Desaules, J.-Y. M. (2025). Quantum many-body scars beyond the PXP model in Rydberg simulators. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.134.160401","ieee":"A. Kerschbaumer, M. Ljubotina, M. Serbyn, and J.-Y. M. Desaules, “Quantum many-body scars beyond the PXP model in Rydberg simulators,” Physical Review Letters, vol. 134, no. 16. American Physical Society, 2025.","ama":"Kerschbaumer A, Ljubotina M, Serbyn M, Desaules J-YM. Quantum many-body scars beyond the PXP model in Rydberg simulators. Physical Review Letters. 2025;134(16). doi:10.1103/PhysRevLett.134.160401","ista":"Kerschbaumer A, Ljubotina M, Serbyn M, Desaules J-YM. 2025. Quantum many-body scars beyond the PXP model in Rydberg simulators. Physical Review Letters. 134(16), 160401."},"OA_type":"hybrid","has_accepted_license":"1","intvolume":" 134","issue":"16","author":[{"first_name":"Aron","full_name":"Kerschbaumer, Aron","id":"ade85a9c-3200-11ee-973b-91c1eb240410","orcid":"0009-0002-2370-8661","last_name":"Kerschbaumer"},{"full_name":"Ljubotina, Marko","id":"F75EE9BE-5C90-11EA-905D-16643DDC885E","orcid":"0000-0003-0038-7068","first_name":"Marko","last_name":"Ljubotina"},{"first_name":"Maksym","full_name":"Serbyn, Maksym","orcid":"0000-0002-2399-5827","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","last_name":"Serbyn"},{"first_name":"Jean-Yves Marc","full_name":"Desaules, Jean-Yves Marc","id":"6c292945-a610-11ed-9eec-c3be1ad62a80","orcid":"0000-0002-3749-6375","last_name":"Desaules"}],"scopus_import":"1","ddc":["530"],"isi":1,"department":[{"_id":"MaSe"}],"article_processing_charge":"Yes (via OA deal)","oa_version":"Published Version","type":"journal_article","month":"04","publication_identifier":{"eissn":["1079-7114"],"issn":["0031-9007"]},"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"doi":"10.1103/PhysRevLett.134.160401","day":"22","_id":"19664","project":[{"call_identifier":"H2020","_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control","grant_number":"850899"},{"call_identifier":"H2020","grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"}],"volume":134,"article_type":"original","article_number":"160401"},{"publisher":"American Chemical Society","PlanS_conform":"1","OA_place":"publisher","abstract":[{"text":"Microsecond-to-millisecond motions are instrumental for many biomolecular functions, including enzymatic activity and ligand binding. Bloch-McConnell Relaxation Dispersion (BMRD) Nuclear Magnetic Resonance (NMR) spectroscopy is a key technique for studying these dynamic processes. While BMRD experiments are routinely used to probe protein motions in solution, the experiment is more demanding in the solid state, where dipolar couplings complicate the spin dynamics. It is believed that high deuteration levels are required and sufficient to obtain accurate and quantitative data. Here we show that even under fast magic-angle spinning and high levels of deuteration artifactual “bumps” in 15N R1ρ BMRD profiles are common. The origin of these artifacts is identified as a second-order three-spin Mixed Rotational and Rotary Resonance (MIRROR) recoupling condition. These artifacts are found to be a significant confounding factor for the accurate quantification of microsecond protein dynamics using BMRD in the solid state. We show that the application of low-power continuous wave (CW) decoupling simultaneously with the 15N spin-lock leads to the suppression of these conditions and enables quantitative measurements of microsecond exchange in the solid state. Remarkably, the application of decoupling allows the measurement of accurate BMRD even in fully protonated proteins at 100 kHz MAS, thus extending the scope of μs dynamics measurements in MAS NMR.","lang":"eng"}],"file":[{"success":1,"file_id":"20337","date_created":"2025-09-10T07:53:10Z","access_level":"open_access","date_updated":"2025-09-10T07:53:10Z","checksum":"b350d56ddddefea96cebd62c277c0ff5","relation":"main_file","content_type":"application/pdf","file_name":"2025_JACS_Tatman.pdf","file_size":5235353,"creator":"dernst"}],"oa":1,"date_updated":"2026-06-10T08:33:41Z","pmid":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication":"Journal of the American Chemical Society","related_material":{"record":[{"relation":"used_in_publication","id":"19696","status":"public"}]},"title":"Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR","acknowledgement":"The authors thank Alexey Krushelnitsky for useful discussions. C.P.J. thanks NSF (MCB-2303862) and NIH (R35GM156238 and S10OD012303) for funding. This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities.","date_created":"2025-09-10T05:37:19Z","file_date_updated":"2025-09-10T07:53:10Z","corr_author":"1","OA_type":"hybrid","citation":{"short":"B. Tatman, V. Sridharan, M. Uttarkabat, C.P. Jaroniec, M. Ernst, P. Rovo, P. Schanda, Journal of the American Chemical Society 147 (2025) 29315–29326.","chicago":"Tatman, Benjamin, Vidhyalakshmi Sridharan, Motilal Uttarkabat, Christopher P. Jaroniec, Matthias Ernst, Petra Rovo, and Paul Schanda. “Bumps on the Road: The Way to Clean Relaxation Dispersion Magic-Angle Spinning NMR.” Journal of the American Chemical Society. American Chemical Society, 2025. https://doi.org/10.1021/jacs.5c09057.","ista":"Tatman B, Sridharan V, Uttarkabat M, Jaroniec CP, Ernst M, Rovo P, Schanda P. 2025. Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR. Journal of the American Chemical Society. 147(32), 29315–29326.","apa":"Tatman, B., Sridharan, V., Uttarkabat, M., Jaroniec, C. P., Ernst, M., Rovo, P., & Schanda, P. (2025). Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR. Journal of the American Chemical Society. American Chemical Society. https://doi.org/10.1021/jacs.5c09057","ieee":"B. Tatman et al., “Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR,” Journal of the American Chemical Society, vol. 147, no. 32. American Chemical Society, pp. 29315–29326, 2025.","ama":"Tatman B, Sridharan V, Uttarkabat M, et al. Bumps on the road: The way to clean relaxation dispersion magic-angle spinning NMR. Journal of the American Chemical Society. 2025;147(32):29315-29326. doi:10.1021/jacs.5c09057","mla":"Tatman, Benjamin, et al. “Bumps on the Road: The Way to Clean Relaxation Dispersion Magic-Angle Spinning NMR.” Journal of the American Chemical Society, vol. 147, no. 32, American Chemical Society, 2025, pp. 29315–26, doi:10.1021/jacs.5c09057."},"publication_status":"published","status":"public","year":"2025","date_published":"2025-08-01T00:00:00Z","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"external_id":{"isi":["001542746200001"],"pmid":["40748291"]},"quality_controlled":"1","author":[{"last_name":"Tatman","id":"71cda2f3-e604-11ee-a1df-da10587eda3f","full_name":"Tatman, Benjamin","first_name":"Benjamin"},{"last_name":"Sridharan","full_name":"Sridharan, Vidhyalakshmi","first_name":"Vidhyalakshmi"},{"first_name":"Motilal","full_name":"Uttarkabat, Motilal","last_name":"Uttarkabat"},{"last_name":"Jaroniec","first_name":"Christopher P.","full_name":"Jaroniec, Christopher P."},{"full_name":"Ernst, Matthias","first_name":"Matthias","last_name":"Ernst"},{"last_name":"Rovo","first_name":"Petra","orcid":"0000-0001-8729-7326","full_name":"Rovo, Petra","id":"c316e53f-b965-11eb-b128-bb26acc59c00"},{"last_name":"Schanda","first_name":"Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606"}],"issue":"32","intvolume":" 147","has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","page":"29315-29326","department":[{"_id":"PaSc"},{"_id":"NMR"}],"isi":1,"ddc":["540"],"scopus_import":"1","month":"08","type":"journal_article","oa_version":"Published Version","volume":147,"_id":"20321","doi":"10.1021/jacs.5c09057","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"day":"01","publication_identifier":{"issn":["0002-7863"],"eissn":["1520-5126"]},"article_type":"original"},{"article_type":"original","_id":"20664","project":[{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"volume":6,"doi":"10.5194/mr-6-243-2025","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"day":"10","publication_identifier":{"eissn":["2699-0016"]},"type":"journal_article","month":"11","oa_version":"Published Version","APC_amount":"1260 EUR","DOAJ_listed":"1","article_processing_charge":"Yes","department":[{"_id":"JoFi"},{"_id":"GaTk"},{"_id":"JoCs"},{"_id":"EvBe"},{"_id":"TaHa"},{"_id":"GradSch"},{"_id":"GeKa"},{"_id":"PaSc"}],"page":"243-256","scopus_import":"1","ddc":["000"],"author":[{"last_name":"Kapoor","id":"84b9700b-15b2-11ec-abd3-831089e67615","full_name":"Kapoor, Lucky","orcid":"0000-0001-8319-2148","first_name":"Lucky"},{"first_name":"Natalia","full_name":"Ruzickova, Natalia","id":"D2761128-D73D-11E9-A1BF-BA0DE6697425","last_name":"Ruzickova"},{"full_name":"Zivadinovic, Predrag","id":"68AA0E5A-AFDA-11E9-9994-141DE6697425","first_name":"Predrag","last_name":"Zivadinovic"},{"last_name":"Leitner","id":"4c665ce3-0016-11ec-bea0-e44de7a4fa3d","full_name":"Leitner, Valentin","first_name":"Valentin"},{"last_name":"Sisak","first_name":"Maria A","full_name":"Sisak, Maria A","id":"44A03D04-AEA4-11E9-B225-EA2DE6697425"},{"last_name":"Mweka","first_name":"Cecelia N","full_name":"Mweka, Cecelia N","id":"2a69ab4b-896a-11ed-bdf8-cb8641cf2b21"},{"full_name":"Dobbelaere, Jeroen A","id":"c15a5412-de82-11ed-b809-8dc1aa996e40","first_name":"Jeroen A","last_name":"Dobbelaere"},{"first_name":"Georgios","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","full_name":"Katsaros, Georgios","orcid":"0000-0001-8342-202X","last_name":"Katsaros"},{"first_name":"Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606","last_name":"Schanda"}],"intvolume":" 6","issue":"2","has_accepted_license":"1","citation":{"mla":"Kapoor, Lucky, et al. “Quantifying the Carbon Footprint of Conference Travel: The Case of NMR Meetings.” Magnetic Resonance, vol. 6, no. 2, Copernicus Publications, 2025, pp. 243–56, doi:10.5194/mr-6-243-2025.","ama":"Kapoor L, Ruzickova N, Zivadinovic P, et al. Quantifying the carbon footprint of conference travel: The case of NMR meetings. Magnetic Resonance. 2025;6(2):243-256. doi:10.5194/mr-6-243-2025","apa":"Kapoor, L., Ruzickova, N., Zivadinovic, P., Leitner, V., Sisak, M. A., Mweka, C. N., … Schanda, P. (2025). Quantifying the carbon footprint of conference travel: The case of NMR meetings. Magnetic Resonance. Copernicus Publications. https://doi.org/10.5194/mr-6-243-2025","ieee":"L. Kapoor et al., “Quantifying the carbon footprint of conference travel: The case of NMR meetings,” Magnetic Resonance, vol. 6, no. 2. Copernicus Publications, pp. 243–256, 2025.","ista":"Kapoor L, Ruzickova N, Zivadinovic P, Leitner V, Sisak MA, Mweka CN, Dobbelaere JA, Katsaros G, Schanda P. 2025. Quantifying the carbon footprint of conference travel: The case of NMR meetings. Magnetic Resonance. 6(2), 243–256.","chicago":"Kapoor, Lucky, Natalia Ruzickova, Predrag Zivadinovic, Valentin Leitner, Maria A Sisak, Cecelia N Mweka, Jeroen A Dobbelaere, Georgios Katsaros, and Paul Schanda. “Quantifying the Carbon Footprint of Conference Travel: The Case of NMR Meetings.” Magnetic Resonance. Copernicus Publications, 2025. https://doi.org/10.5194/mr-6-243-2025.","short":"L. Kapoor, N. Ruzickova, P. Zivadinovic, V. Leitner, M.A. Sisak, C.N. Mweka, J.A. Dobbelaere, G. Katsaros, P. Schanda, Magnetic Resonance 6 (2025) 243–256."},"file_date_updated":"2025-11-24T08:25:19Z","OA_type":"gold","corr_author":"1","date_published":"2025-11-10T00:00:00Z","year":"2025","status":"public","publication_status":"published","language":[{"iso":"eng"}],"quality_controlled":"1","date_updated":"2026-06-10T08:45:11Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Quantifying the carbon footprint of conference travel: The case of NMR meetings","publication":"Magnetic Resonance","related_material":{"record":[{"status":"public","relation":"research_data","id":"20242"}],"link":[{"relation":"research_data","description":"News on ISTA website","url":"https://ista.ac.at/en/news/carbon-footprint-of-conference-travel/"}]},"date_created":"2025-11-23T23:01:39Z","acknowledgement":"First and foremost, we are grateful to the conference organizers who have provided data, either in the form of tables or by pointing us to abstract books. We thank the reviewers and the handling editor (Gottfried Otting) for the careful reading and suggestions. This project emerged from an interactive course about energy and climate, held at IST Austria by Jeroen Dobbelaere, Georgios Katsaros and Paul Schanda. We are grateful to ISTA's Graduate School for enabling this interdisciplinary course and to all participating students. We thank the following persons for discussions and/or comments about the manuscript: Helene Van Melckebeke, Mei Hong, Jeff Hoch, Gottfried Otting and Matthias Ernst. For the preparation of the manuscript, AI tools have been used, namely for finding relevant literature (ChatGPT) and for correcting the text (Writefull, within Overleaf LaTeX).","publisher":"Copernicus Publications","OA_place":"publisher","abstract":[{"lang":"eng","text":"Conference travel contributes to the climate footprint of academic research. Here, we provide a quantitative estimate of the carbon emissions associated with conference attendance by analyzing travel data from participants of 10 international conferences in the field of magnetic resonance, namely EUROMAR, ENC and ICMRBS. We find that attending a EUROMAR conference produces, on average, more than 1 t CO2 eq.. For the analyzed conferences outside Europe, the corresponding value is about 2–3 times higher, on average, with intercontinental trips amounting to up to 5 t. We compare these conference-related emissions to other activities associated with research and show that conference travel is a substantial portion of the total climate footprint of a researcher in magnetic resonance. We explore several strategies to reduce these emissions, including the impact of selecting conference venues more strategically and the possibility of decentralized conferences. Through a detailed comparison of train versus air travel – accounting for both direct and infrastructure-related emissions – we demonstrate that train travel offers considerable carbon savings. These data may provide a basis for strategic choices of future conferences in the field and for individuals deciding on their conference attendance."}],"file":[{"file_id":"20672","success":1,"date_created":"2025-11-24T08:25:19Z","access_level":"open_access","date_updated":"2025-11-24T08:25:19Z","checksum":"c63dd47b0e77f9451821436bb77d27c9","relation":"main_file","content_type":"application/pdf","file_name":"2025_MagneticResonance_Kapoor.pdf","file_size":3081399,"creator":"dernst"}],"PlanS_conform":"1","oa":1},{"ec_funded":1,"publisher":"Institute of Science and Technology Austria","oa":1,"abstract":[{"lang":"eng","text":"Persistent revivals recently observed in Rydberg atom simulators have challenged our understanding of thermalization and attracted much interest to the concept of quantum many-body scars (QMBSs). QMBSs are non-thermal highly excited eigenstates that coexist with typical eigenstates in the spectrum of many-body Hamiltonians, and have since been reported in multiple theoretical models, including the so-called PXP model, approximately realized by Rydberg simulators. At the same time, questions of how common QMBSs are and in what models they are physically realized remain open. In this Letter, we demonstrate that QMBSs exist in a broader family of models that includes and generalizes PXP to longer-range constraints and states with different periodicity. We show that in each model, multiple QMBS families can be found. Each of them relies on a different approximate 𝔰𝔲(2) algebra, leading to oscillatory dynamics in all cases. However, in contrast to the PXP model, their observation requires launching dynamics from weakly entangled initial states rather than from a product state. QMBSs reported here may be experimentally probed using Rydberg atom simulator in the regime of longer-range Rydberg blockades."}],"file":[{"success":1,"date_created":"2025-05-05T07:14:17Z","file_id":"19646","access_level":"open_access","date_updated":"2025-05-05T07:14:17Z","checksum":"d073314c4dc95d93feaadbff188ce4a1","relation":"main_file","content_type":"application/zip","file_name":"Data+Code.zip","file_size":583478621,"creator":"jdesaule"},{"date_updated":"2025-05-05T07:13:46Z","access_level":"open_access","success":1,"date_created":"2025-05-05T07:13:46Z","file_id":"19647","file_size":15856,"file_name":"readme.txt","creator":"jdesaule","checksum":"d386a2364fb1147ef6dad30ad029c080","content_type":"text/plain","relation":"main_file"}],"date_updated":"2026-06-10T08:40:52Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","date_created":"2025-04-24T19:58:46Z","acknowledgement":"The authors are grateful to Zlatko Papić, Dolev Bluvstein, Nishad Maskara, Marcello Dalmonte, Thomas Iadecola, and Johannes Feldmeier for insightful discussions. A. K., M. L., and M. S. acknowledge support by the European Research Council under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899). J.-Y. D. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 101034413.","title":"Research Data for \"Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators\"","related_material":{"record":[{"relation":"used_in_publication","id":"19664","status":"public"}]},"keyword":["quantum many-body scars","non-equilibrium physics","Rydberg atoms"],"year":"2025","date_published":"2025-04-24T00:00:00Z","status":"public","file_date_updated":"2025-05-05T07:14:17Z","corr_author":"1","citation":{"ama":"Desaules J-YM. Research Data for “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” 2025. doi:10.15479/AT:ISTA:19623","ieee":"J.-Y. M. Desaules, “Research Data for ‘Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.’” Institute of Science and Technology Austria, 2025.","apa":"Desaules, J.-Y. M. (2025). Research Data for “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:19623","ista":"Desaules J-YM. 2025. Research Data for ‘Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:19623.","mla":"Desaules, Jean-Yves Marc. Research Data for “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” Institute of Science and Technology Austria, 2025, doi:10.15479/AT:ISTA:19623.","short":"J.-Y.M. Desaules, (2025).","chicago":"Desaules, Jean-Yves Marc. “Research Data for ‘Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.’” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT:ISTA:19623."},"acknowledged_ssus":[{"_id":"ScienComp"}],"author":[{"full_name":"Desaules, Jean-Yves Marc","id":"6c292945-a610-11ed-9eec-c3be1ad62a80","orcid":"0000-0002-3749-6375","first_name":"Jean-Yves Marc","last_name":"Desaules"}],"has_accepted_license":"1","article_processing_charge":"No","ddc":["530"],"department":[{"_id":"MaSe"}],"oa_version":"Published Version","type":"research_data","month":"04","project":[{"call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program"},{"grant_number":"850899","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control","_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","call_identifier":"H2020"}],"_id":"19623","day":"24","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)"},"doi":"10.15479/AT:ISTA:19623","contributor":[{"first_name":"Aron","id":"ade85a9c-3200-11ee-973b-91c1eb240410","last_name":"Kerschbaumer","contributor_type":"researcher"},{"last_name":"Ljubotina","first_name":"Marko","contributor_type":"researcher"},{"contributor_type":"researcher","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2399-5827","first_name":"Maksym","last_name":"Serbyn"},{"first_name":"Jean-Yves Marc","orcid":"0000-0002-3749-6375","id":"6c292945-a610-11ed-9eec-c3be1ad62a80","last_name":"Desaules","contributor_type":"researcher"}]},{"author":[{"last_name":"Agafonova","id":"09501ff6-dca7-11ea-a8ae-b3e0b9166e80","orcid":"0000-0003-0582-2946","full_name":"Agafonova, Sofya","first_name":"Sofya"}],"has_accepted_license":"1","contributor":[{"first_name":"Pere","last_name":"Rosello"},{"first_name":"Manuel","last_name":"Mekonnen"},{"id":"4C02D85E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2031-204X","first_name":"Onur","last_name":"Hosten","contributor_type":"supervisor"}],"citation":{"mla":"Agafonova, Sofia. Research Data for: “One-Milligram Torsional Pendulum toward Experiments at the Quantum-Gravity Interface.” Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20842.","ista":"Agafonova S. 2025. Research Data for: ‘One-milligram torsional pendulum toward experiments at the quantum-gravity interface’, Institute of Science and Technology Austria, 10.15479/AT-ISTA-20842.","apa":"Agafonova, S. (2025). Research Data for: “One-milligram torsional pendulum toward experiments at the quantum-gravity interface.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20842","ieee":"S. Agafonova, “Research Data for: ‘One-milligram torsional pendulum toward experiments at the quantum-gravity interface.’” Institute of Science and Technology Austria, 2025.","ama":"Agafonova S. Research Data for: “One-milligram torsional pendulum toward experiments at the quantum-gravity interface.” 2025. doi:10.15479/AT-ISTA-20842","chicago":"Agafonova, Sofia. “Research Data for: ‘One-Milligram Torsional Pendulum toward Experiments at the Quantum-Gravity Interface.’” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20842.","short":"S. Agafonova, (2025)."},"corr_author":"1","file_date_updated":"2025-12-22T13:51:09Z","status":"public","_id":"20842","date_published":"2025-12-22T00:00:00Z","year":"2025","project":[{"grant_number":"101087907","name":"A quantum hybrid of atoms and milligram-scale pendulums: towards gravitational quantum mechanics","_id":"bdb2a702-d553-11ed-ba76-f12e3e5a3bc6"}],"doi":"10.15479/AT-ISTA-20842","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"day":"22","date_updated":"2026-06-10T08:36:07Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","month":"12","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"20840"}]},"type":"research_data","title":"Research Data for: 'One-milligram torsional pendulum toward experiments at the quantum-gravity interface'","oa_version":"Published Version","date_created":"2025-12-21T14:23:50Z","publisher":"Institute of Science and Technology Austria","article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"OnHo"}],"file":[{"checksum":"7af34e4226a00cdcb7f154272050e217","relation":"main_file","content_type":"application/x-zip-compressed","file_size":146656591,"file_name":"AllData.zip","creator":"sagafono","date_created":"2025-12-22T13:45:30Z","file_id":"20854","success":1,"access_level":"open_access","date_updated":"2025-12-22T13:45:30Z"},{"date_updated":"2025-12-22T13:45:33Z","access_level":"open_access","success":1,"date_created":"2025-12-22T13:45:33Z","file_id":"20855","creator":"sagafono","file_name":"SourceData.zip","file_size":93470129,"content_type":"application/x-zip-compressed","relation":"main_file","checksum":"71806a2ef9fb26ad7b78e04c6754ee4e"},{"date_created":"2025-12-22T13:51:09Z","file_id":"20856","success":1,"date_updated":"2025-12-22T13:51:09Z","access_level":"open_access","relation":"main_file","content_type":"text/plain","checksum":"08facd1b4a102f83e4d99d48a85b258d","creator":"sagafono","file_size":461,"file_name":"readme.txt"}],"abstract":[{"lang":"eng","text":"Probing the possibility of entanglement generation through gravity offers a path to tackle the question of whether gravitational fields possess a quantum mechanical nature. A potential realization necessitates systems with low-frequency dynamics at an optimal mass scale, for which the microgram-to-milligram range is a strong contender. Here, after refining a figure-of-merit for the problem, we present a 1-milligram torsional pendulum operating at 18 Hz. We demonstrate laser cooling its motion from room temperature to 240~microkelvins, surpassing by over 20-fold the coldest motions attained for oscillators ranging from micrograms to kilograms. We quantify and contrast the utility of the current approach with other platforms. The achieved performance and large improvement potential highlight milligram-scale torsional pendulums as a powerful platform for precision measurements relevant to future studies at the quantum-gravity interface."}],"oa":1},{"status":"public","date_published":"2025-09-01T00:00:00Z","_id":"20242","year":"2025","file_date_updated":"2025-09-01T11:05:27Z","corr_author":"1","citation":{"short":"P. Schanda, (2025).","chicago":"Schanda, Paul. “Data of: ‘Quantifying the Carbon Footprint of Conference Travel: The Case of NMR Meetings.’” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20242.","ieee":"P. Schanda, “Data of: ‘Quantifying the carbon footprint of conference travel: the case of NMR meetings.’” Institute of Science and Technology Austria, 2025.","apa":"Schanda, P. (2025). Data of: “Quantifying the carbon footprint of conference travel: the case of NMR meetings.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20242","ama":"Schanda P. Data of: “Quantifying the carbon footprint of conference travel: the case of NMR meetings.” 2025. doi:10.15479/AT-ISTA-20242","ista":"Schanda P. 2025. Data of: ‘Quantifying the carbon footprint of conference travel: the case of NMR meetings’, Institute of Science and Technology Austria, 10.15479/AT-ISTA-20242.","mla":"Schanda, Paul. 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Meyling for the fungal strain, and the ISTA Social Immunity team, Jonghyun Park and Yuko Ulrich for ant collection. We also thank the Social Immunity team, in particular David Moreno Martínez, Tanvi Madaan, Wilfrid Jean Louis and Jessica Kirchner, for experimental and molecular support, as well as Friedrich Fochler for technical support with the chemical analysis, and the ISTA Lab Support Facility, including the mass spectrometry unit, for general and chemical laboratory support. We further thank Marco Ribezzi for advice on 13C calculations and Ernst Pittenauer for discussion of the chemical data, Chris Pull and Michael Sixt for project discussion and the Social Immunity team for comments on the manuscript. The study was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation Programme (No. 771402; EPIDEMICSonCHIP) to SC. ","title":"Altruistic disease signalling in ant colonies","keyword":["host-parasite interactions","social insects","social immunity","chemical communication","cooperation"],"related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"18892"}]},"project":[{"call_identifier":"H2020","_id":"2649B4DE-B435-11E9-9278-68D0E5697425","grant_number":"771402","name":"Epidemics in ant societies on a chip"}],"_id":"20471","day":"16","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"doi":"10.15479/AT-ISTA-20471","contributor":[{"id":"31B4E2D0-F248-11E8-B48F-1D18A9856A87","first_name":"Erika","last_name":"Dawson"},{"first_name":"Michaela","id":"953894f3-25bd-11ec-8556-f70a9d38ef60","last_name":"Hönigsberger"},{"last_name":"Kampleitner","first_name":"Niklas","id":"2AC57FAC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","last_name":"Grasse"},{"id":"85f0e6d3-06b3-11ec-8982-8c5049fa4455","first_name":"Lukas","last_name":"Lindorfer"},{"last_name":"Robb","first_name":"Jennifer","id":"7bc2734a-e2c6-11ea-9824-a2ed5f0662a8"},{"id":"0344bfb9-3feb-11ee-87e9-c27edc800bcd","first_name":"Farnaz","last_name":"Beikzadeh Abbasi"},{"last_name":"Strahodinsky","id":"979E35EE-C996-11E9-8C7C-CF13E6697425","first_name":"Florian"},{"first_name":"Hanna","id":"8fc5c6f6-5903-11ec-abad-c83f046253e7","last_name":"Leitner"},{"id":"876b6b34-8ff4-11ec-97c9-8d95a7aae416","first_name":"Harikrishnan","last_name":"Rajendran"},{"last_name":"Schmitt","first_name":"Thomas"},{"last_name":"Cremer","first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868"}],"article_processing_charge":"No","ddc":["570"],"department":[{"_id":"SyCr"}],"oa_version":"Published Version","type":"research_data","month":"10"},{"article_processing_charge":"No","ddc":["539","570"],"department":[{"_id":"GradSch"},{"_id":"EdHa"},{"_id":"MiSi"},{"_id":"NanoFab"},{"_id":"AnSa"}],"oa_version":"Preprint","month":"09","type":"preprint","project":[{"name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces","grant_number":"101071793","_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd"},{"grant_number":"26360","name":"Motile active matter models of migrating cells and chiral filaments","_id":"34d75525-11ca-11ed-8bc3-89b6307fee9d"}],"_id":"21427","day":"25","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"doi":"10.1101/2025.05.20.655037","publisher":"bioRxiv","oa":1,"OA_place":"repository","abstract":[{"lang":"eng","text":"While tumor malignancy has been extensively studied under the prism of genetic and epigenetic heterogeneity, tumor cell states also critically depend on reciprocal interactions with the microenvironment. This raises the hitherto untested possibility that heterogeneity of the untransformed tumor stroma can actively fuel malignant progression. As biological heterogeneity is inherently difficult to control, we adopted a reductionist approach and let tumor cells invade micro-engineered environments harboring obstacles with precision-controlled geometry. We find that not only the presence of obstacles, but more surprisingly their spatial disorder, causes a drastic shift from a collective to a single-cell mode of invasion – comparable in strength to cadherin loss. Combining live-imaging and perturbation experiments with minimal biophysical modeling, we demonstrate that cell detachments result both from local geometrical constraints and a global integration of spatial disorder over time. We show that different types of microenvironments map onto different universality classes of invasion dynamics - homogeneous substrates follow Kardar–Parisi–Zhang (KPZ) scaling, while disordered ones exhibit exponents consistent with KPZ with quenched disorder (KPZq). Our findings highlight generic physical principles for how the mode of cancer cell invasion depends on environmental heterogeneity, with potential implications to understand tumor evolution in vivo."}],"date_updated":"2026-06-10T09:41:11Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.05.20.655037"}],"acknowledgement":"European Research Council, https://ror.org/0472cxd90, 101071793\r\nAustrian Academy of Sciences, 26360","date_created":"2026-03-11T08:40:06Z","related_material":{"record":[{"relation":"dissertation_contains","id":"21423","status":"public"},{"status":"public","relation":"research_data","id":"21439"}]},"title":"Substrate heterogeneity promotes cancer cell dissemination through interface roughening","publication_status":"draft","status":"public","date_published":"2025-09-25T00:00:00Z","year":"2025","corr_author":"1","citation":{"mla":"Dunajova, Zuzana, et al. Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening. bioRxiv, doi:10.1101/2025.05.20.655037.","ista":"Dunajova Z, Tasciyan S, Majek J, Merrin J, Sahai E, Sixt MK, Hannezo EB. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. 10.1101/2025.05.20.655037.","ieee":"Z. Dunajova et al., “Substrate heterogeneity promotes cancer cell dissemination through interface roughening.” bioRxiv.","apa":"Dunajova, Z., Tasciyan, S., Majek, J., Merrin, J., Sahai, E., Sixt, M. K., & Hannezo, E. B. (n.d.). Substrate heterogeneity promotes cancer cell dissemination through interface roughening. bioRxiv. https://doi.org/10.1101/2025.05.20.655037","ama":"Dunajova Z, Tasciyan S, Majek J, et al. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. doi:10.1101/2025.05.20.655037","chicago":"Dunajova, Zuzana, Saren Tasciyan, Juraj Majek, Jack Merrin, Erik Sahai, Michael K Sixt, and Edouard B Hannezo. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” bioRxiv, n.d. https://doi.org/10.1101/2025.05.20.655037.","short":"Z. Dunajova, S. Tasciyan, J. Majek, J. Merrin, E. Sahai, M.K. Sixt, E.B. Hannezo, (n.d.)."},"language":[{"iso":"eng"}],"author":[{"first_name":"Zuzana","id":"4B39F286-F248-11E8-B48F-1D18A9856A87","full_name":"Dunajova, Zuzana","last_name":"Dunajova"},{"first_name":"Saren","full_name":"Tasciyan, Saren","id":"4323B49C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1671-393X","last_name":"Tasciyan"},{"first_name":"Juraj","full_name":"Majek, Juraj","id":"3e6d9473-f38e-11ec-8ae0-c4e05a8aa9e1","last_name":"Majek"},{"last_name":"Merrin","orcid":"0000-0001-5145-4609","id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack","first_name":"Jack"},{"first_name":"Erik","full_name":"Sahai, Erik","last_name":"Sahai"},{"last_name":"Sixt","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","first_name":"Michael K"},{"last_name":"Hannezo","first_name":"Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561"}],"has_accepted_license":"1"},{"publisher":"American Physical Society","PlanS_conform":"1","abstract":[{"lang":"eng","text":"Superconductor–semiconductor hybrid systems play a crucial role in realizing nanoscale quantum devices, including hybrid qubits, Majorana bound states, and Kitaev chains. For such hybrid devices, subgap states play a prominent role in their operation. In this paper, we study these subgap states via Coulomb and tunneling spectroscopy through a superconducting island defined in a semiconductor nanowire fully coated by a superconductor. We systematically explore regimes ranging from an almost decoupled island to the open configuration. In the weak-coupling regime, the experimental observations are very similar in the absence of a magnetic field and when one flux quantum pierces the superconducting shell. Conversely, in the strong-coupling regime, significant distinctions emerge between the two cases. We attribute this distinct behavior to the existence of subgap states at one flux quantum, which become observable only for sufficiently strong coupling to the leads. We support our interpretation using a simple model to describe transport through the island. Our study highlights the importance of studying a broad range of tunnel couplings for understanding the rich physics of hybrid devices."}],"file":[{"file_size":1977581,"file_name":"2025_PhysReviewResearch_Valentini.pdf","creator":"dernst","checksum":"535351066e9c900340ef014893a09ac8","relation":"main_file","content_type":"application/pdf","date_updated":"2025-04-22T09:00:08Z","access_level":"open_access","success":1,"file_id":"19604","date_created":"2025-04-22T09:00:08Z"}],"OA_place":"publisher","oa":1,"date_updated":"2026-06-11T09:13:12Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Physical Review Research","title":"Subgap transport in superconductor-semiconductor hybrid islands: Weak and strong coupling regimes","acknowledgement":"This research was supported by the Scientific Service Units of ISTA, through resources provided by the MIBA Machine Shop and the Nanofabrication facility. This research and related results were made possible with the support of the FWF Project with DOI10.55776/F86. We acknowledge support from the European Research Council under the European Unions Horizon 2020 research and innovation programme under Grant Agreement No. 856526, the Swedish Research Council under Grant Agreement No. 2020-03412, the Spanish Comunidad de Madrid (CM) “Talento Program” (Project No. 2022-T1/IND-24070), the Spanish Ministry of Science, innovation, and Universities through Grant PID2022-140552NA-I00 and NanoLund.","date_created":"2025-04-20T22:01:28Z","citation":{"mla":"Valentini, Marco, et al. “Subgap Transport in Superconductor-Semiconductor Hybrid Islands: Weak and Strong Coupling Regimes.” Physical Review Research, vol. 7, no. 2, 023022, American Physical Society, 2025, doi:10.1103/PhysRevResearch.7.023022.","ama":"Valentini M, Souto RS, Borovkov M, et al. Subgap transport in superconductor-semiconductor hybrid islands: Weak and strong coupling regimes. Physical Review Research. 2025;7(2). doi:10.1103/PhysRevResearch.7.023022","apa":"Valentini, M., Souto, R. S., Borovkov, M., Krogstrup, P., Meir, Y., Leijnse, M., … Katsaros, G. (2025). Subgap transport in superconductor-semiconductor hybrid islands: Weak and strong coupling regimes. Physical Review Research. American Physical Society. https://doi.org/10.1103/PhysRevResearch.7.023022","ieee":"M. Valentini et al., “Subgap transport in superconductor-semiconductor hybrid islands: Weak and strong coupling regimes,” Physical Review Research, vol. 7, no. 2. American Physical Society, 2025.","ista":"Valentini M, Souto RS, Borovkov M, Krogstrup P, Meir Y, Leijnse M, Danon J, Katsaros G. 2025. Subgap transport in superconductor-semiconductor hybrid islands: Weak and strong coupling regimes. Physical Review Research. 7(2), 023022.","chicago":"Valentini, Marco, Rubén Seoane Souto, Maksim Borovkov, Peter Krogstrup, Yigal Meir, Martin Leijnse, Jeroen Danon, and Georgios Katsaros. “Subgap Transport in Superconductor-Semiconductor Hybrid Islands: Weak and Strong Coupling Regimes.” Physical Review Research. American Physical Society, 2025. https://doi.org/10.1103/PhysRevResearch.7.023022.","short":"M. Valentini, R.S. Souto, M. Borovkov, P. Krogstrup, Y. Meir, M. Leijnse, J. Danon, G. Katsaros, Physical Review Research 7 (2025)."},"file_date_updated":"2025-04-22T09:00:08Z","corr_author":"1","OA_type":"hybrid","publication_status":"published","status":"public","date_published":"2025-04-01T00:00:00Z","year":"2025","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"language":[{"iso":"eng"}],"quality_controlled":"1","author":[{"full_name":"Valentini, Marco","id":"C0BB2FAC-D767-11E9-B658-BC13E6697425","first_name":"Marco","last_name":"Valentini"},{"full_name":"Souto, Rubén Seoane","first_name":"Rubén Seoane","last_name":"Souto"},{"last_name":"Borovkov","full_name":"Borovkov, Maksim","id":"1fd0975f-8b61-11ed-b69e-d149334f28c5","first_name":"Maksim"},{"full_name":"Krogstrup, Peter","first_name":"Peter","last_name":"Krogstrup"},{"last_name":"Meir","full_name":"Meir, Yigal","first_name":"Yigal"},{"full_name":"Leijnse, Martin","first_name":"Martin","last_name":"Leijnse"},{"last_name":"Danon","first_name":"Jeroen","full_name":"Danon, Jeroen"},{"first_name":"Georgios","orcid":"0000-0001-8342-202X","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","full_name":"Katsaros, Georgios","last_name":"Katsaros"}],"issue":"2","intvolume":" 7","has_accepted_license":"1","article_processing_charge":"Yes","department":[{"_id":"GeKa"}],"ddc":["530"],"scopus_import":"1","month":"04","type":"journal_article","DOAJ_listed":"1","oa_version":"Published Version","APC_amount":"3036,92 EUR","volume":7,"_id":"19597","project":[{"name":"Center for Correlated Quantum Materials and Solid State Quantum Systems: Conventional and unconventional topological superconductors","grant_number":"F8606","_id":"34a66131-11ca-11ed-8bc3-a31681c6b03e"}],"day":"01","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"doi":"10.1103/PhysRevResearch.7.023022","publication_identifier":{"issn":["2643-1564"]},"article_number":"023022","article_type":"original"},{"article_number":"pgaf252","article_type":"original","volume":4,"_id":"20254","project":[{"grant_number":"863818","name":"Formal Methods for Stochastic Models: Algorithms and Applications","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020"}],"publication_identifier":{"eissn":["2752-6542"]},"doi":"10.1093/pnasnexus/pgaf252","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"day":"01","DOAJ_listed":"1","oa_version":"Published Version","APC_amount":"4493,27 EUR","month":"08","type":"journal_article","article_processing_charge":"Yes","ddc":["000"],"scopus_import":"1","department":[{"_id":"KrCh"}],"issue":"8","intvolume":" 4","author":[{"full_name":"Brewster, David A.","first_name":"David A.","last_name":"Brewster"},{"first_name":"Jakub","orcid":"0000-0002-1419-3267","full_name":"Svoboda, Jakub","id":"130759D2-D7DD-11E9-87D2-DE0DE6697425","last_name":"Svoboda"},{"full_name":"Roscow, Dylan","first_name":"Dylan","last_name":"Roscow"},{"last_name":"Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X"},{"full_name":"Tkadlec, Josef","orcid":"0000-0002-1097-9684","id":"3F24CCC8-F248-11E8-B48F-1D18A9856A87","first_name":"Josef","last_name":"Tkadlec"},{"last_name":"Nowak","full_name":"Nowak, Martin A.","first_name":"Martin A."}],"has_accepted_license":"1","publication_status":"published","status":"public","date_published":"2025-08-01T00:00:00Z","year":"2025","citation":{"mla":"Brewster, David A., et al. “Maintaining Diversity in Structured Populations.” PNAS Nexus, vol. 4, no. 8, pgaf252, Oxford University Press, 2025, doi:10.1093/pnasnexus/pgaf252.","ama":"Brewster DA, Svoboda J, Roscow D, Chatterjee K, Tkadlec J, Nowak MA. Maintaining diversity in structured populations. PNAS Nexus. 2025;4(8). doi:10.1093/pnasnexus/pgaf252","apa":"Brewster, D. A., Svoboda, J., Roscow, D., Chatterjee, K., Tkadlec, J., & Nowak, M. A. (2025). Maintaining diversity in structured populations. PNAS Nexus. Oxford University Press. https://doi.org/10.1093/pnasnexus/pgaf252","ieee":"D. A. Brewster, J. Svoboda, D. Roscow, K. Chatterjee, J. Tkadlec, and M. A. Nowak, “Maintaining diversity in structured populations,” PNAS Nexus, vol. 4, no. 8. Oxford University Press, 2025.","ista":"Brewster DA, Svoboda J, Roscow D, Chatterjee K, Tkadlec J, Nowak MA. 2025. Maintaining diversity in structured populations. PNAS Nexus. 4(8), pgaf252.","chicago":"Brewster, David A., Jakub Svoboda, Dylan Roscow, Krishnendu Chatterjee, Josef Tkadlec, and Martin A. Nowak. “Maintaining Diversity in Structured Populations.” PNAS Nexus. Oxford University Press, 2025. https://doi.org/10.1093/pnasnexus/pgaf252.","short":"D.A. Brewster, J. Svoboda, D. Roscow, K. Chatterjee, J. Tkadlec, M.A. Nowak, PNAS Nexus 4 (2025)."},"file_date_updated":"2025-09-03T06:20:08Z","OA_type":"gold","quality_controlled":"1","external_id":{"arxiv":["2503.09841"]},"language":[{"iso":"eng"}],"arxiv":1,"date_updated":"2026-06-11T09:11:17Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"J.S. and K.C. were supported by the European Research Council CoG 863818 (ForM-SMArt) and Austrian Science Fund 10.55776/COE12. J.T. was supported by GAČR grant 25-17377S and by Charles Univ. projects UNCE 24/SCI/008 and PRIMUS 24/SCI/012.","date_created":"2025-08-31T22:01:32Z","publication":"PNAS Nexus","title":"Maintaining diversity in structured populations","ec_funded":1,"publisher":"Oxford University Press","oa":1,"PlanS_conform":"1","abstract":[{"lang":"eng","text":"We examine population structures for their ability to maintain diversity in neutral evolution. We use the general framework of evolutionary graph theory and consider birth–death (bd) and death–birth (db) updating. The population is of size N. Initially all individuals represent different types. The basic question is: what is the time TN until one type takes over the population? This time is known as consensus time in computer science and as total coalescent time in evolutionary biology. For the complete graph, it is known that TN is quadratic in N for db and bd. For the cycle, we prove that TN is cubic in N for db and bd. For the star, we prove that TN is cubic for bd and quasilinear (N log N) for db. For the double star, we show that TN is quartic for bd. We derive upper and lower bounds for all undirected graphs for bd and db. We also show the Pareto front of graphs (of size N = 8) that maintain diversity the longest for bd and db. Further, we show that some graphs that quickly homogenize can maintain high levels of diversity longer than graphs that slowly homogenize. For directed graphs, we give simple contracting star-like structures that have superexponential time scales for maintaining diversity."}],"file":[{"file_size":1086419,"file_name":"2025_PNASNexus_Brewster.pdf","creator":"dernst","checksum":"8a5e82c6f842e3220ec96028c9374b69","relation":"main_file","content_type":"application/pdf","access_level":"open_access","date_updated":"2025-09-03T06:20:08Z","success":1,"date_created":"2025-09-03T06:20:08Z","file_id":"20280"}],"OA_place":"publisher"},{"oa_version":"Preprint","date_created":"2026-01-20T10:12:21Z","acknowledgement":"Y. B. B. and L. F. were funded by the Independent Research Fund Denmark, grant\r\nnumber 1026-00037. T. H. was partially supported by the European Research Council\r\n(ERC) Horizon 2020, grant number 788183.","type":"preprint","title":"Identifying cobordisms using kernel persistence","publication":"arXiv","month":"05","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2505.17858","open_access":"1"}],"date_updated":"2026-06-11T11:51:13Z","arxiv":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"OA_place":"repository","department":[{"_id":"HeEd"}],"abstract":[{"lang":"eng","text":"Motivated by applications in chemistry, we give a homlogical definition of tunnels, or more generally cobordisms, connecting disjoint parts of a cell complex. For a filtered complex, this defines a persistence module. We give a method for identifying birth and death times using kernel persistence and a matrix reduction algorithm for pairing birth and death times."}],"ec_funded":1,"article_processing_charge":"No","article_number":"2505.17858","author":[{"last_name":"Bleile","first_name":"Yossi","orcid":"0000-0002-4861-9174","id":"920a7385-7995-11ef-9bfd-8c434cd8f3c2","full_name":"Bleile, Yossi"},{"last_name":"Fajstrup","first_name":"Lisbeth","full_name":"Fajstrup, Lisbeth"},{"last_name":"Heiss","id":"4879BB4E-F248-11E8-B48F-1D18A9856A87","full_name":"Heiss, Teresa","orcid":"0000-0002-1780-2689","first_name":"Teresa"},{"last_name":"Svane","first_name":"Anne Marie","full_name":"Svane, Anne Marie"},{"last_name":"Sørensen","first_name":"Søren Strandskov","full_name":"Sørensen, Søren Strandskov"}],"day":"23","doi":"10.48550/arXiv.2505.17858","language":[{"iso":"eng"}],"external_id":{"arxiv":["2505.17858"]},"_id":"21016","project":[{"call_identifier":"H2020","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","grant_number":"788183","name":"Alpha Shape Theory Extended"}],"date_published":"2025-05-23T00:00:00Z","year":"2025","status":"public","publication_status":"submitted","citation":{"short":"Y. Bokor Bleile, L. Fajstrup, T. Heiss, A.M. Svane, S.S. Sørensen, ArXiv (n.d.).","chicago":"Bokor Bleile, Yossi, Lisbeth Fajstrup, Teresa Heiss, Anne Marie Svane, and Søren Strandskov Sørensen. “Identifying Cobordisms Using Kernel Persistence.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2505.17858.","apa":"Bokor Bleile, Y., Fajstrup, L., Heiss, T., Svane, A. M., & Sørensen, S. S. (n.d.). Identifying cobordisms using kernel persistence. arXiv. https://doi.org/10.48550/arXiv.2505.17858","ieee":"Y. Bokor Bleile, L. Fajstrup, T. Heiss, A. M. Svane, and S. S. Sørensen, “Identifying cobordisms using kernel persistence,” arXiv. .","ama":"Bokor Bleile Y, Fajstrup L, Heiss T, Svane AM, Sørensen SS. Identifying cobordisms using kernel persistence. arXiv. doi:10.48550/arXiv.2505.17858","ista":"Bokor Bleile Y, Fajstrup L, Heiss T, Svane AM, Sørensen SS. Identifying cobordisms using kernel persistence. arXiv, 2505.17858.","mla":"Bokor Bleile, Yossi, et al. “Identifying Cobordisms Using Kernel Persistence.” ArXiv, 2505.17858, doi:10.48550/arXiv.2505.17858."}},{"page":"1630-1654","department":[{"_id":"VlKo"},{"_id":"GradSch"}],"article_processing_charge":"No","month":"09","type":"journal_article","oa_version":"Preprint","doi":"10.1137/24m1664691","day":"01","publication_identifier":{"issn":["1052-6234"],"eissn":["1095-7189"]},"volume":35,"_id":"21144","article_type":"original","OA_place":"repository","abstract":[{"lang":"eng","text":"This paper deals with the algorithmic aspects of solving feasibility problems of semidefinite programming (SDP), aka linear matrix inequalities (LMIs). Since in some SDP instances all feasible solutions have irrational entries, numerical solvers that work with rational numbers can only find an approximate solution. We study the following question: Is it possible to certify feasibility of a given SDP using an approximate solution that is sufficiently close to some exact solution? Existing approaches make the assumption that there exist rational feasible solutions (and use techniques such as rounding and lattice reduction algorithms). We propose an alternative approach that does not need this assumption. More specifically, we show how to construct a system of polynomial equations whose set of real solutions is guaranteed to have an isolated correct solution (assuming that the target exact solution is maximum-rank). This allows, in particular, for us to use algorithms from real algebraic geometry for solving systems of polynomial equations, yielding a hybrid (or symbolic-numerical) method for SDPs. We experimentally compare it with a pure symbolic method in [D. Henrion, S. Naldi, and M. Safey El Din, SIAM J. Optim., 26 (2016), pp. 2512–2539]; the hybrid method was able to certify feasibility of many SDP instances on which the aforementioned paper failed. Our approach may have further applications, such as refining an approximate solution using methods of numerical algebraic geometry for systems of polynomial equations."}],"oa":1,"publisher":"Society for Industrial and Applied Mathematics","publication":"SIAM Journal on Optimization","related_material":{"record":[{"id":"21957","relation":"dissertation_contains","status":"public"}]},"title":"Certifying solutions of degenerate semidefinite programs","date_created":"2026-02-05T13:33:05Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2405.13625"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-06-12T10:36:59Z","arxiv":1,"language":[{"iso":"eng"}],"external_id":{"arxiv":["2405.13625"]},"quality_controlled":"1","citation":{"short":"V. Kolmogorov, S. Naldi, J. Zapata, SIAM Journal on Optimization 35 (2025) 1630–1654.","chicago":"Kolmogorov, Vladimir, Simone Naldi, and Jeferson Zapata. “Certifying Solutions of Degenerate Semidefinite Programs.” SIAM Journal on Optimization. Society for Industrial and Applied Mathematics, 2025. https://doi.org/10.1137/24m1664691.","apa":"Kolmogorov, V., Naldi, S., & Zapata, J. (2025). Certifying solutions of degenerate semidefinite programs. SIAM Journal on Optimization. Society for Industrial and Applied Mathematics. https://doi.org/10.1137/24m1664691","ieee":"V. Kolmogorov, S. Naldi, and J. Zapata, “Certifying solutions of degenerate semidefinite programs,” SIAM Journal on Optimization, vol. 35, no. 3. Society for Industrial and Applied Mathematics, pp. 1630–1654, 2025.","ama":"Kolmogorov V, Naldi S, Zapata J. Certifying solutions of degenerate semidefinite programs. SIAM Journal on Optimization. 2025;35(3):1630-1654. doi:10.1137/24m1664691","ista":"Kolmogorov V, Naldi S, Zapata J. 2025. Certifying solutions of degenerate semidefinite programs. SIAM Journal on Optimization. 35(3), 1630–1654.","mla":"Kolmogorov, Vladimir, et al. “Certifying Solutions of Degenerate Semidefinite Programs.” SIAM Journal on Optimization, vol. 35, no. 3, Society for Industrial and Applied Mathematics, 2025, pp. 1630–54, doi:10.1137/24m1664691."},"OA_type":"green","publication_status":"published","status":"public","date_published":"2025-09-01T00:00:00Z","year":"2025","author":[{"last_name":"Kolmogorov","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","full_name":"Kolmogorov, Vladimir","first_name":"Vladimir"},{"last_name":"Naldi","full_name":"Naldi, Simone","first_name":"Simone"},{"id":"00223538-AF8F-11E9-A4C7-F729E6697425","full_name":"Zapata, Jeferson","first_name":"Jeferson","last_name":"Zapata"}],"issue":"3","intvolume":" 35"},{"degree_awarded":"PhD","publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-20777","day":"11","_id":"20777","project":[{"_id":"eb943429-77a9-11ec-83b8-9f471cdf5c67","name":"Functional Advantages of Critical Brain Dynamics","grant_number":"M03318"}],"supervisor":[{"orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","last_name":"Csicsvari"}],"oa_version":"Published Version","type":"dissertation","month":"12","ddc":["570","539","571"],"department":[{"_id":"GradSch"},{"_id":"JoCs"}],"page":"104","article_processing_charge":"No","has_accepted_license":"1","author":[{"last_name":"Zivadinovic","first_name":"Predrag","id":"68AA0E5A-AFDA-11E9-9994-141DE6697425","full_name":"Zivadinovic, Predrag"}],"language":[{"iso":"eng"}],"date_published":"2025-12-11T00:00:00Z","year":"2025","status":"public","publication_status":"published","citation":{"ista":"Zivadinovic P. 2025. Scale-free activity as a basis for spatial learning and memory in the brain. Institute of Science and Technology Austria.","ieee":"P. Zivadinovic, “Scale-free activity as a basis for spatial learning and memory in the brain,” Institute of Science and Technology Austria, 2025.","ama":"Zivadinovic P. Scale-free activity as a basis for spatial learning and memory in the brain. 2025. doi:10.15479/AT-ISTA-20777","apa":"Zivadinovic, P. (2025). Scale-free activity as a basis for spatial learning and memory in the brain. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20777","mla":"Zivadinovic, Predrag. Scale-Free Activity as a Basis for Spatial Learning and Memory in the Brain. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20777.","short":"P. Zivadinovic, Scale-Free Activity as a Basis for Spatial Learning and Memory in the Brain, Institute of Science and Technology Austria, 2025.","chicago":"Zivadinovic, Predrag. “Scale-Free Activity as a Basis for Spatial Learning and Memory in the Brain.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20777."},"corr_author":"1","alternative_title":["ISTA Thesis"],"file_date_updated":"2026-06-11T22:30:02Z","date_created":"2025-12-10T19:37:41Z","acknowledgement":"My work has been funded through the project \"Functional Advantages of Critical Brain\r\nDynamics\" of the ISTA interdisciplinary fund and through the FWF.\r\n","title":"Scale-free activity as a basis for spatial learning and memory in the brain","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-06-11T22:30:03Z","oa":1,"OA_place":"publisher","file":[{"creator":"pzivadin","file_name":"2025_Zivadinovic_Predrag_PhD_thesis.pdf","file_size":8105379,"relation":"main_file","content_type":"application/pdf","checksum":"aae9d1ed53f7b67f75e289c26a02b72f","embargo":"2026-06-11","date_updated":"2026-06-11T22:30:02Z","access_level":"open_access","file_id":"20778","date_created":"2025-12-10T19:28:20Z"},{"embargo_to":"open_access","checksum":"8a08a3804ce7d9d625fdf1631113da8c","content_type":"application/zip","relation":"source_file","file_name":"2025_Zivadinovic_Predrag_PhD_thesis_source.zip","file_size":8512240,"creator":"pzivadin","file_id":"20779","date_created":"2025-12-10T19:28:10Z","access_level":"closed","date_updated":"2026-06-11T22:30:02Z"}],"publisher":"Institute of Science and Technology Austria"},{"oa_version":"Published Version","month":"05","type":"dissertation","ddc":["570"],"page":"133","department":[{"_id":"MiSi"},{"_id":"GradSch"}],"article_processing_charge":"No","degree_awarded":"PhD","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-058-9"]},"day":"27","doi":"10.15479/AT-ISTA-19745","supervisor":[{"last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K"}],"project":[{"call_identifier":"H2020","grant_number":"665385","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","_id":"265E2996-B435-11E9-9278-68D0E5697425","name":"Nano-Analytics of Cellular Systems","grant_number":"W01250-B20"}],"_id":"19745","acknowledgement":"This project has received funding from the Austrian Science Fund (FWF) via the doctorate\r\ncollege DK NanoCell and from the European Union’s Horizon 2020 research and innovation\r\nprogramme under the Marie Skłodowska-Curie Grant Agreement No. 665385.\r\n","date_created":"2025-05-26T08:49:00Z","related_material":{"record":[{"relation":"part_of_dissertation","id":"14274","status":"public"}]},"title":"Adaptive strategies of dendritic cell migration in response to environmental cues","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-04-07T12:38:44Z","oa":1,"OA_place":"publisher","OA_embargo":"6","abstract":[{"text":"Cell migration is a crucial process in animal development and maintenance. It is incredibly\r\nheterogeneous, with different cell types utilizing fundamentally distinct migration strategies.\r\nThe strategies also depend on the cellular microenvironment, where cells can switch between\r\nmigration modes as they encounter new environmental cues. In this thesis, we investigated\r\nhow dendritic cells adapt their migration strategy when encountering geometrically,\r\nmechanically and chemically distinct environments.\r\nWhen dendritic cells are embedded in a homogeneous fibrous network, they migrate in a fast\r\nand directional amoeboid manner. In this migration strategy, extracellular proteolysis and\r\nintegrin-mediated adhesions are dispensable. Instead, the cells use topography of the\r\nenvironment to propel their cell body forward. To migrate efficiently in the maze of different\r\npore sizes, they position the nucleus ahead of the microtubule organizing center (MTOC) and\r\nuse it to gauge the pores to identify the path of least resistance. Our aim was to identify\r\nwhether dendritic cells adapt their migration strategy when encountering asymmetrical\r\ntransitions into much denser environments with limited choice of large pores. In such invasive\r\ntransitions it is unclear if the cells can cross tight pores without the use of adhesions and\r\nextracellular proteolysis and whether they maintain the nucleus in the cell front.\r\nUsing various cell migration assays such as fibrous 3D collagen gels, geometrically defined\r\nmicrochannels with constrictions and simplistic under agarose migration assay, we provide\r\na comprehensive characterization of invasive migration of dendritic cells. We show that\r\nduring invasion the cells stall and stretch, reflecting the difficulty to translocate the bulky cell\r\nbody into the dense environment. In collagen gels, we show that dendritic cells can invade\r\nwithout proteolysis and adhesions. Instead, they utilize contractility, which can lead to largescale collagen compressions. During invasion, the nucleus stalls at tight constrictions, leading\r\nto a transient organelle reorientation. To resolve the stalling, upregulated rear contractility is\r\nrequired. This contractile force is simultaneously necessary for reverting the nucleus back to\r\nthe cell front after invasion and maintaining this positioning during permissive migration.\r\nA functional role of the reorientation was uncovered in the first collaboration project.\r\nA prominent central actin pool was identified around the MTOC, especially pronounced in\r\ndense and compressive environments. The actin pool was shown to generate pushing forces\r\nto dilate the space for cell translocation. These forces are only necessary in non-permissive\r\nenvironments, where the nucleus reorients to the cell rear, allowing the actin pool to\r\ngenerate space. In permissive environments where space generation is dispensable, the\r\nMTOC is located behind the nucleus and the actin cloud has reduced intensity, allowing more\r\nactin to be incorporated into the lamellipodium, speeding up migration.\r\nIn the second collaboration project, we investigated the effects of distinct chemical\r\nenvironments on dendritic cell migration. The strikingly persistent migration of these cells\r\nwas explained by their ability to modulate and even self-generate chemokine gradients. This\r\nallows the cells to migrate faster and more persistent in uniform chemokine fields compared\r\nto imposed chemokine gradients. The chemokine receptor CCR7 was identified as a crucial\r\nplayer in this process, both sensing the signal and internalizing the chemokine to create a sink.","lang":"eng"}],"file":[{"checksum":"1a2d1525d19347fbb879ef57c02951bf","embargo_to":"open_access","relation":"source_file","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"NikolaCanigova_Thesis_final.docx","file_size":103879193,"creator":"cchlebak","date_created":"2025-05-28T07:38:17Z","file_id":"19748","access_level":"closed","date_updated":"2025-11-27T23:30:02Z"},{"relation":"main_file","content_type":"application/pdf","checksum":"c1d8f9a40a8e19fcf895373f4b773a46","creator":"cchlebak","file_name":"NikolaCanigova_Thesis_final_PDFA2a_fixed.pdf","file_size":194530600,"date_created":"2025-05-28T07:39:53Z","file_id":"19749","embargo":"2025-11-27","access_level":"open_access","date_updated":"2025-11-27T23:30:02Z"}],"ec_funded":1,"publisher":"Institute of Science and Technology Austria","has_accepted_license":"1","author":[{"full_name":"Canigova, Nikola","orcid":"0000-0002-8518-5926","id":"3795523E-F248-11E8-B48F-1D18A9856A87","first_name":"Nikola","last_name":"Canigova"}],"language":[{"iso":"eng"}],"publication_status":"published","status":"public","date_published":"2025-05-27T00:00:00Z","year":"2025","citation":{"short":"N. Canigova, Adaptive Strategies of Dendritic Cell Migration in Response to Environmental Cues, Institute of Science and Technology Austria, 2025.","chicago":"Canigova, Nikola. “Adaptive Strategies of Dendritic Cell Migration in Response to Environmental Cues.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19745.","ista":"Canigova N. 2025. Adaptive strategies of dendritic cell migration in response to environmental cues. Institute of Science and Technology Austria.","ieee":"N. Canigova, “Adaptive strategies of dendritic cell migration in response to environmental cues,” Institute of Science and Technology Austria, 2025.","ama":"Canigova N. Adaptive strategies of dendritic cell migration in response to environmental cues. 2025. doi:10.15479/AT-ISTA-19745","apa":"Canigova, N. (2025). Adaptive strategies of dendritic cell migration in response to environmental cues. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19745","mla":"Canigova, Nikola. Adaptive Strategies of Dendritic Cell Migration in Response to Environmental Cues. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19745."},"file_date_updated":"2025-11-27T23:30:02Z","corr_author":"1","alternative_title":["ISTA Thesis"]},{"abstract":[{"lang":"eng","text":"Gene expression is crucial for cell differentiation, development and survival of\r\norganisms. It consists of several steps, starting with transcription that is mediated by\r\nRNA polymerases. These are protein machineries transcribing and producing different\r\ntypes of RNAs. Although, the individual steps of transcription by RNA polymerase II\r\n(Pol II) as well as the structure of Pol II has been extensively studied, surprisingly,\r\nthere is still little known about its regulation and assembly in cytoplasm. Among the\r\nproteins that are important in biogenesis of Pol II are RNA polymerase II associating\r\nproteins (RPAP) and small GPN-loop GTPases (GPN). Both of these protein groups\r\nwere shown to take essential part in assembly of Pol II.\r\nThe aim of this project was to deepen our knowledge in regulation of Pol II in\r\nthe cytoplasm as well as the proteins involved in this process. Techniques of structural\r\nbiology, biochemistry and cell biology were employed to study and characterize cytoplasmic Pol II and its interacting partners.\r\nThis study shows for the first time the structure of cytoplasmic Pol II at high\r\nresolution. The structure also reveals proteins interacting with Pol II in cytoplasm,\r\nnamely GDOWN1, RPAP2. Comparing the structure of cytoplasmic Pol II with transcribing Pol II revealed striking difference in clamp region that is not in closed state.\r\nFurthermore, GDOWN1 and RPAP2 make steric clashes with various transcription\r\nfactors bound to Pol II during different stages of transcription. Even though GPN1 and\r\nGPN3 proteins were not resolved in the cytoplasmic Pol II structure, they are part of\r\nthe complex and their interaction with Pol II was confirmed in vitro. RPAP2 stabilizes\r\nthese proteins on Pol II and several experiments suggest that they interact with the\r\nclamp region. In addition, GDOWN1, RPAP2 and GPNs might keep clamp in open or\r\npartially open state. Based on these results I propose a novel model of regulation of\r\nPol II in cytoplasm. GDOWN1, RPAP2, GPN1 and GPN3 bind to Pol II in cytoplasm\r\nand doing so they can prevent pre-mature binding of DNA or RNA and different transcription factors to Pol II in cytoplasm or before engaging in transcription nucleus.\r\nThis research contributes to the current knowledge of molecular mechanisms\r\nof Pol II regulation in cytoplasm."}],"file":[{"embargo_to":"open_access","checksum":"b7ddf424ffe95f8c767c53c8bb62d4f3","relation":"source_file","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"PhD_Thesis_Hlavata_final_submission.docx","file_size":23506747,"creator":"ahlavata","file_id":"19448","date_created":"2025-03-24T12:48:36Z","date_updated":"2026-03-20T23:30:04Z","access_level":"closed"},{"creator":"ahlavata","file_name":"PhD_Thesis_Hlavata_final_submission_update.pdf","file_size":9478591,"relation":"main_file","content_type":"application/pdf","checksum":"6c5a59c9bac467c3d0b3ffb8ea6d9fd4","embargo":"2026-03-20","date_updated":"2026-03-20T23:30:04Z","access_level":"open_access","file_id":"19449","date_created":"2025-03-24T12:51:10Z"}],"OA_place":"publisher","oa":1,"publisher":"Institute of Science and Technology Austria","title":"Regulation of Cytoplasmic RNA Polymerase II","acknowledgement":"I would also like to acknowledge the ISTA Facilities: Lab Support Facility, Protein Services and Electron Microscopy Facility (EMF) and Scientific Computing. EMF for their support during data collections and troubleshooting, especially Valentin. Scientific Computing for solving quickly any issues related with cluster.","date_created":"2025-03-20T12:52:47Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-04-07T11:46:32Z","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"EM-Fac"},{"_id":"ScienComp"}],"language":[{"iso":"eng"}],"file_date_updated":"2026-03-20T23:30:04Z","citation":{"short":"A. Hlavata, Regulation of Cytoplasmic RNA Polymerase II, Institute of Science and Technology Austria, 2025.","chicago":"Hlavata, Annamaria. “Regulation of Cytoplasmic RNA Polymerase II.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/10.15479/AT-ISTA-19431.","ista":"Hlavata A. 2025. Regulation of Cytoplasmic RNA Polymerase II. Institute of Science and Technology Austria.","apa":"Hlavata, A. (2025). Regulation of Cytoplasmic RNA Polymerase II. Institute of Science and Technology Austria. https://doi.org/10.15479/10.15479/AT-ISTA-19431","ama":"Hlavata A. Regulation of Cytoplasmic RNA Polymerase II. 2025. doi:10.15479/10.15479/AT-ISTA-19431","ieee":"A. Hlavata, “Regulation of Cytoplasmic RNA Polymerase II,” Institute of Science and Technology Austria, 2025.","mla":"Hlavata, Annamaria. Regulation of Cytoplasmic RNA Polymerase II. Institute of Science and Technology Austria, 2025, doi:10.15479/10.15479/AT-ISTA-19431."},"corr_author":"1","alternative_title":["ISTA Thesis"],"publication_status":"published","status":"public","year":"2025","date_published":"2025-03-20T00:00:00Z","has_accepted_license":"1","author":[{"id":"36062FEC-F248-11E8-B48F-1D18A9856A87","full_name":"Hlavata, Annamaria","first_name":"Annamaria","last_name":"Hlavata"}],"page":"83","department":[{"_id":"GradSch"},{"_id":"CaBe"}],"ddc":["572"],"article_processing_charge":"No","month":"03","type":"dissertation","oa_version":"Published Version","day":"20","doi":"10.15479/10.15479/AT-ISTA-19431","publication_identifier":{"eissn":["2663-337X"],"isbn":["978-3-99078-055-8"]},"supervisor":[{"first_name":"Carrie A","full_name":"Bernecky, Carrie A","orcid":"0000-0003-0893-7036","id":"2CB9DFE2-F248-11E8-B48F-1D18A9856A87","last_name":"Bernecky"}],"_id":"19431","degree_awarded":"PhD"}]