[{"author":[{"last_name":"Herdina","first_name":"Anna Nele","full_name":"Herdina, Anna Nele"},{"full_name":"Bozdogan, Anil","first_name":"Anil","last_name":"Bozdogan"},{"full_name":"Aspermair, Patrik","first_name":"Patrik","last_name":"Aspermair"},{"full_name":"Dostalek, Jakub","last_name":"Dostalek","first_name":"Jakub"},{"full_name":"Klausberger, Miriam","first_name":"Miriam","last_name":"Klausberger"},{"full_name":"Lingg, Nico","first_name":"Nico","last_name":"Lingg"},{"first_name":"Monika","last_name":"Cserjan-Puschmann","full_name":"Cserjan-Puschmann, Monika"},{"last_name":"Aguilar","first_name":"Patricia Pereira","full_name":"Aguilar, Patricia Pereira"},{"full_name":"Auer, Simone","first_name":"Simone","last_name":"Auer"},{"last_name":"Demirtas","first_name":"Halil","full_name":"Demirtas, Halil"},{"last_name":"Andersson","first_name":"Jakob","id":"3a5f4167-9bd9-11ed-bd12-a1446d38776f","full_name":"Andersson, Jakob"},{"first_name":"Felix","last_name":"Lötsch","full_name":"Lötsch, Felix"},{"last_name":"Holzer","first_name":"Barbara","full_name":"Holzer, Barbara"},{"full_name":"Steinrigl, Adi","first_name":"Adi","last_name":"Steinrigl"},{"full_name":"Thalhammer, Florian","last_name":"Thalhammer","first_name":"Florian"},{"full_name":"Schellnegger, Julia","first_name":"Julia","last_name":"Schellnegger"},{"first_name":"Monika","last_name":"Breuer","full_name":"Breuer, Monika"},{"first_name":"Wolfgang","last_name":"Knoll","full_name":"Knoll, Wolfgang"},{"first_name":"Robert","last_name":"Strassl","full_name":"Strassl, Robert"}],"oa_version":"Published Version","article_number":"116807","citation":{"apa":"Herdina, A. N., Bozdogan, A., Aspermair, P., Dostalek, J., Klausberger, M., Lingg, N., … Strassl, R. (2025). Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements. <i>Biosensors and Bioelectronics</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.bios.2024.116807\">https://doi.org/10.1016/j.bios.2024.116807</a>","ama":"Herdina AN, Bozdogan A, Aspermair P, et al. Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements. <i>Biosensors and Bioelectronics</i>. 2025;267. doi:<a href=\"https://doi.org/10.1016/j.bios.2024.116807\">10.1016/j.bios.2024.116807</a>","chicago":"Herdina, Anna Nele, Anil Bozdogan, Patrik Aspermair, Jakub Dostalek, Miriam Klausberger, Nico Lingg, Monika Cserjan-Puschmann, et al. “Bridging Basic Science and Applied Diagnostics: Comprehensive Viral Diagnostics Enabled by Graphene-Based Electronic Biosensor Technology Advancements.” <i>Biosensors and Bioelectronics</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.bios.2024.116807\">https://doi.org/10.1016/j.bios.2024.116807</a>.","ista":"Herdina AN, Bozdogan A, Aspermair P, Dostalek J, Klausberger M, Lingg N, Cserjan-Puschmann M, Aguilar PP, Auer S, Demirtas H, Andersson J, Lötsch F, Holzer B, Steinrigl A, Thalhammer F, Schellnegger J, Breuer M, Knoll W, Strassl R. 2025. Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements. Biosensors and Bioelectronics. 267, 116807.","mla":"Herdina, Anna Nele, et al. “Bridging Basic Science and Applied Diagnostics: Comprehensive Viral Diagnostics Enabled by Graphene-Based Electronic Biosensor Technology Advancements.” <i>Biosensors and Bioelectronics</i>, vol. 267, 116807, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.bios.2024.116807\">10.1016/j.bios.2024.116807</a>.","ieee":"A. N. Herdina <i>et al.</i>, “Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements,” <i>Biosensors and Bioelectronics</i>, vol. 267. Elsevier, 2025.","short":"A.N. Herdina, A. Bozdogan, P. Aspermair, J. Dostalek, M. Klausberger, N. Lingg, M. Cserjan-Puschmann, P.P. Aguilar, S. Auer, H. Demirtas, J. Andersson, F. Lötsch, B. Holzer, A. Steinrigl, F. Thalhammer, J. Schellnegger, M. Breuer, W. Knoll, R. Strassl, Biosensors and Bioelectronics 267 (2025)."},"abstract":[{"text":"This study presents a graphene field-effect transistor (gFET) biosensor with dual detection capabilities for SARS-CoV-2: one RNA detection assay to confirm viral positivity and the other for nucleocapsid (N-)protein detection as a proxy for infectiousness of the patient. This technology can be rapidly adapted to emerging infectious diseases, making an essential tool to contain future pandemics. To detect viral RNA, the highly conserved E-gene of the virus was targeted, allowing for the determination of SARS-CoV-2 presence or absence using nasopharyngeal swab samples. For N-protein detection, specific antibodies were used. Tested on 213 clinical nasopharyngeal samples, the gFET biosensor showed good correlation with RT-PCR cycle threshold values, proving its high sensitivity in detecting SARS-CoV-2 RNA. Specificity was confirmed using 21 pre-pandemic samples positive for other respiratory viruses. The gFET biosensor had a limit of detection (LOD) for N-protein of 0.9 pM, establishing a foundation for the development of a sensitive tool for monitoring active viral infection. Results of gFET based N-protein detection corresponded to the results of virus culture in all 16 available clinical samples and thus it also proved its capability to serve as a proxy for infectivity. Overall, these findings support the potential of the gFET biosensor as a point-of-care device for rapid diagnosis of SARS-CoV-2 infection and indirect assessment of infectiousness in patients, providing additional information for clinical and public health decision-making.","lang":"eng"}],"type":"journal_article","publication_identifier":{"issn":["0956-5663"],"eissn":["1873-4235"]},"date_updated":"2025-02-27T12:34:07Z","year":"2025","title":"Bridging basic science and applied diagnostics: Comprehensive viral diagnostics enabled by graphene-based electronic biosensor technology advancements","file_date_updated":"2025-01-13T11:14:32Z","has_accepted_license":"1","volume":267,"date_published":"2025-01-01T00:00:00Z","article_type":"original","language":[{"iso":"eng"}],"scopus_import":"1","doi":"10.1016/j.bios.2024.116807","month":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"day":"01","date_created":"2024-10-06T22:01:11Z","pmid":1,"publication_status":"published","intvolume":"       267","department":[{"_id":"LeSa"}],"publisher":"Elsevier","oa":1,"file":[{"content_type":"application/pdf","date_updated":"2025-01-13T11:14:32Z","access_level":"open_access","file_id":"18843","relation":"main_file","creator":"dernst","success":1,"checksum":"208ac27dab27af792d198fcb74af8756","date_created":"2025-01-13T11:14:32Z","file_size":4135372,"file_name":"2025_BiosensorsBioelectronics_Herdina.pdf"}],"OA_place":"publisher","status":"public","publication":"Biosensors and Bioelectronics","quality_controlled":"1","external_id":{"pmid":["39341071"],"isi":["001328413700001"]},"ddc":["570"],"isi":1,"article_processing_charge":"Yes (in subscription journal)","_id":"18170","OA_type":"hybrid","acknowledgement":"This research was funded in whole by the Austrian Science Fund (FWF) [P 35103-B, Grant-DOI: 10.55776/P35103]. For open access purposes, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission. We would like to thank Olfert Landt for advice on ssDNA probe design; Rui Qiang Chen, Jennifer Stock, and Christine Wukotitsch for their excellent support with ONT sequencing; Christoph Köppl and Andreas Fischer for excellent support in recombinant N protein expression and purification; and the whole team at the division of clinical virology for their support with standard diagnostics."},{"page":"615-637","publisher":"Mathematical Sciences Publishers","oa":1,"OA_place":"repository","status":"public","publication":"Pure and Applied Analysis","das_tickbox":"1","external_id":{"arxiv":["2411.05300"]},"quality_controlled":"1","OA_type":"green","_id":"22021","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2411.05300"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"3","day":"18","date_created":"2026-06-19T07:30:23Z","mathsc":["35Q53","35Q55","37K10"],"publication_status":"published","intvolume":"         7","date_published":"2025-06-18T00:00:00Z","volume":7,"article_type":"original","language":[{"iso":"eng"}],"extern":"1","scopus_import":"1","month":"06","doi":"10.2140/paa.2025.7.615","author":[{"full_name":"Haque, Saikatul","last_name":"Haque","first_name":"Saikatul"},{"full_name":"Killip, Rowan","last_name":"Killip","first_name":"Rowan"},{"last_name":"Visan","first_name":"Monica","id":"056daca0-b8d1-11f0-964f-f91054abf8ca","full_name":"Visan, Monica"},{"last_name":"Zhang","first_name":"Yunfeng","full_name":"Zhang, Yunfeng"}],"oa_version":"Preprint","citation":{"apa":"Haque, S., Killip, R., Vişan, M., &#38; Zhang, Y. (2025).  Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces. <i>Pure and Applied Analysis</i>. Mathematical Sciences Publishers. <a href=\"https://doi.org/10.2140/paa.2025.7.615\">https://doi.org/10.2140/paa.2025.7.615</a>","ama":"Haque S, Killip R, Vişan M, Zhang Y.  Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces. <i>Pure and Applied Analysis</i>. 2025;7(3):615-637. doi:<a href=\"https://doi.org/10.2140/paa.2025.7.615\">10.2140/paa.2025.7.615</a>","ista":"Haque S, Killip R, Vişan M, Zhang Y. 2025.  Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces. Pure and Applied Analysis. 7(3), 615–637.","chicago":"Haque, Saikatul, Rowan Killip, Monica Vişan, and Yunfeng Zhang. “ Global Well-Posedness and Equicontinuity for Modified Korteweg–de Vries Equations in Modulation Spaces.” <i>Pure and Applied Analysis</i>. Mathematical Sciences Publishers, 2025. <a href=\"https://doi.org/10.2140/paa.2025.7.615\">https://doi.org/10.2140/paa.2025.7.615</a>.","ieee":"S. Haque, R. Killip, M. Vişan, and Y. Zhang, “ Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces,” <i>Pure and Applied Analysis</i>, vol. 7, no. 3. Mathematical Sciences Publishers, pp. 615–637, 2025.","mla":"Haque, Saikatul, et al. “ Global Well-Posedness and Equicontinuity for Modified Korteweg–de Vries Equations in Modulation Spaces.” <i>Pure and Applied Analysis</i>, vol. 7, no. 3, Mathematical Sciences Publishers, 2025, pp. 615–37, doi:<a href=\"https://doi.org/10.2140/paa.2025.7.615\">10.2140/paa.2025.7.615</a>.","short":"S. Haque, R. Killip, M. Vişan, Y. Zhang, Pure and Applied Analysis 7 (2025) 615–637."},"abstract":[{"text":"We establish global well-posedness for both the defocusing and\r\nfocusing complex-valued modified Korteweg–de Vries equations on the real line\r\nin modulation spaces Ms,2p (R), for all 1 \u0014 p < 1 and 0 \u0014 s < 3/2 − 1/p. We\r\nwill also show that such solutions admit global-in-time bounds in these spaces\r\nand that equicontinuous sets of initial data lead to equicontinuous ensembles\r\nof orbits. Indeed, such information forms a crucial part of our well-posedness\r\nargument.","lang":"eng"}],"arxiv":1,"type":"journal_article","publication_identifier":{"eissn":["2578-5885"],"issn":["2578-5893"]},"date_updated":"2026-06-24T13:22:40Z","year":"2025","title":" Global well-posedness and equicontinuity for modified Korteweg–de Vries equations in modulation spaces"},{"oa_version":"Preprint","author":[{"full_name":"Hu, Nicholas","last_name":"Hu","first_name":"Nicholas"},{"last_name":"Killip","first_name":"Rowan","full_name":"Killip, Rowan"},{"id":"056daca0-b8d1-11f0-964f-f91054abf8ca","full_name":"Visan, Monica","last_name":"Visan","first_name":"Monica"}],"citation":{"apa":"Hu, N., Killip, R., &#38; Vişan, M. (2025). Deconvolutional determination of the nonlinearity in a semilinear wave equation. <i>Pure and Applied Analysis</i>. Mathematical Sciences Publishers. <a href=\"https://doi.org/10.2140/paa.2025.7.1\">https://doi.org/10.2140/paa.2025.7.1</a>","ama":"Hu N, Killip R, Vişan M. Deconvolutional determination of the nonlinearity in a semilinear wave equation. <i>Pure and Applied Analysis</i>. 2025;7(1):1-17. doi:<a href=\"https://doi.org/10.2140/paa.2025.7.1\">10.2140/paa.2025.7.1</a>","ista":"Hu N, Killip R, Vişan M. 2025. Deconvolutional determination of the nonlinearity in a semilinear wave equation. Pure and Applied Analysis. 7(1), 1–17.","chicago":"Hu, Nicholas, Rowan Killip, and Monica Vişan. “Deconvolutional Determination of the Nonlinearity in a Semilinear Wave Equation.” <i>Pure and Applied Analysis</i>. Mathematical Sciences Publishers, 2025. <a href=\"https://doi.org/10.2140/paa.2025.7.1\">https://doi.org/10.2140/paa.2025.7.1</a>.","ieee":"N. Hu, R. Killip, and M. Vişan, “Deconvolutional determination of the nonlinearity in a semilinear wave equation,” <i>Pure and Applied Analysis</i>, vol. 7, no. 1. Mathematical Sciences Publishers, pp. 1–17, 2025.","mla":"Hu, Nicholas, et al. “Deconvolutional Determination of the Nonlinearity in a Semilinear Wave Equation.” <i>Pure and Applied Analysis</i>, vol. 7, no. 1, Mathematical Sciences Publishers, 2025, pp. 1–17, doi:<a href=\"https://doi.org/10.2140/paa.2025.7.1\">10.2140/paa.2025.7.1</a>.","short":"N. Hu, R. Killip, M. Vişan, Pure and Applied Analysis 7 (2025) 1–17."},"abstract":[{"text":"We demonstrate that in three space dimensions, the scattering behaviour of semilinear wave equations with quintic-type nonlinearities uniquely determines the nonlinearity. The nonlinearity is permitted to depend on both space and time.","lang":"eng"}],"date_updated":"2026-06-24T13:24:38Z","arxiv":1,"type":"journal_article","publication_identifier":{"issn":["2578-5893"],"eissn":["2578-5885"]},"title":"Deconvolutional determination of the nonlinearity in a semilinear wave equation","year":"2025","date_published":"2025-01-22T00:00:00Z","volume":7,"language":[{"iso":"eng"}],"extern":"1","article_type":"original","scopus_import":"1","month":"01","doi":"10.2140/paa.2025.7.1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2307.00829","open_access":"1"}],"day":"22","date_created":"2026-06-19T07:36:00Z","issue":"1","mathsc":["35L70","35P25","35R30"],"intvolume":"         7","keyword":["dispersive equations","nonlinear wave equation","semilinear wave equation","scattering","inverse scattering","deconvolution"],"publication_status":"published","oa":1,"page":"1-17","publisher":"Mathematical Sciences Publishers","status":"public","publication":"Pure and Applied Analysis","OA_place":"repository","quality_controlled":"1","external_id":{"arxiv":["2307.00829"]},"OA_type":"green","_id":"22027","article_processing_charge":"No"},{"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2402.03218","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"1","day":"01","date_created":"2026-06-19T07:47:06Z","publication_status":"published","intvolume":"        38","publisher":"IOP Publishing","oa":1,"OA_place":"repository","status":"public","publication":"Nonlinearity","das_tickbox":"1","quality_controlled":"1","external_id":{"arxiv":["2402.03218"]},"OA_type":"green","_id":"22044","article_processing_charge":"No","author":[{"last_name":"Killip","first_name":"Rowan","full_name":"Killip, Rowan"},{"full_name":"Murphy, Jason","first_name":"Jason","last_name":"Murphy"},{"last_name":"Visan","first_name":"Monica","id":"056daca0-b8d1-11f0-964f-f91054abf8ca","full_name":"Visan, Monica"}],"oa_version":"Preprint","article_number":"015021","citation":{"chicago":"Killip, Rowan, Jason Murphy, and Monica Vişan. “Determination of Schrödinger Nonlinearities from the Scattering Map.” <i>Nonlinearity</i>. IOP Publishing, 2025. <a href=\"https://doi.org/10.1088/1361-6544/ada1bf\">https://doi.org/10.1088/1361-6544/ada1bf</a>.","ista":"Killip R, Murphy J, Vişan M. 2025. Determination of Schrödinger nonlinearities from the scattering map. Nonlinearity. 38(1), 015021.","ieee":"R. Killip, J. Murphy, and M. Vişan, “Determination of Schrödinger nonlinearities from the scattering map,” <i>Nonlinearity</i>, vol. 38, no. 1. IOP Publishing, 2025.","mla":"Killip, Rowan, et al. “Determination of Schrödinger Nonlinearities from the Scattering Map.” <i>Nonlinearity</i>, vol. 38, no. 1, 015021, IOP Publishing, 2025, doi:<a href=\"https://doi.org/10.1088/1361-6544/ada1bf\">10.1088/1361-6544/ada1bf</a>.","short":"R. Killip, J. Murphy, M. Vişan, Nonlinearity 38 (2025).","apa":"Killip, R., Murphy, J., &#38; Vişan, M. (2025). Determination of Schrödinger nonlinearities from the scattering map. <i>Nonlinearity</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1361-6544/ada1bf\">https://doi.org/10.1088/1361-6544/ada1bf</a>","ama":"Killip R, Murphy J, Vişan M. Determination of Schrödinger nonlinearities from the scattering map. <i>Nonlinearity</i>. 2025;38(1). doi:<a href=\"https://doi.org/10.1088/1361-6544/ada1bf\">10.1088/1361-6544/ada1bf</a>"},"abstract":[{"lang":"eng","text":"We prove that the small-data scattering map uniquely determines the nonlinearity for a wide class of gauge-invariant, intercritical nonlinear Schrödinger equations. We use the Born approximation to reduce the analysis to a deconvolution problem involving the distribution function for linear Schrödinger solutions. We then solve this deconvolution problem using the Beurling–Lax Theorem."}],"arxiv":1,"type":"journal_article","publication_identifier":{"eissn":["1361-6544"],"issn":["0951-7715"]},"date_updated":"2026-06-25T07:46:14Z","year":"2025","title":"Determination of Schrödinger nonlinearities from the scattering map","volume":38,"date_published":"2025-01-01T00:00:00Z","article_type":"original","language":[{"iso":"eng"}],"extern":"1","scopus_import":"1","doi":"10.1088/1361-6544/ada1bf","month":"01"},{"volume":45,"date_published":"2025-03-01T00:00:00Z","extern":"1","language":[{"iso":"eng"}],"article_type":"original","scopus_import":"1","month":"03","doi":"10.3934/dcds.2024114","oa_version":"Preprint","author":[{"last_name":"Killip","first_name":"Rowan","full_name":"Killip, Rowan"},{"first_name":"Zhimeng","last_name":"Ouyang","full_name":"Ouyang, Zhimeng"},{"first_name":"Monica","last_name":"Visan","full_name":"Visan, Monica","id":"056daca0-b8d1-11f0-964f-f91054abf8ca"},{"first_name":"Lei","last_name":"Wu","full_name":"Wu, Lei"}],"abstract":[{"lang":"eng","text":"For slowly-varying initial data, solutions to the Ablowitz–Ladik system have been proven to converge to solutions of the cubic Schrödinger equation. In this paper we show that in the continuum limit, solutions to the Ablowitz–Ladik system with H^1 initial data may also converge to solutions of the modified Korteweg–de Vries equation. To exhibit this new limiting behavior, it suffices that the initial data is supported near the inflection points of the dispersion relation associated with the Ablowitz–Ladik system.\r\n\r\nOur arguments employ harmonic analysis tools, Strichartz estimates, and the conservation of mass and energy. Correspondingly, they are applicable beyond the completely integrable models of greatest interest to us."}],"citation":{"apa":"Killip, R., Ouyang, Z., Vişan, M., &#38; Wu, L. (2025). The modified Korteweg–de Vries limit of the Ablowitz–Ladik system. <i>Discrete and Continuous Dynamical Systems</i>. American Institute of Mathematical Sciences. <a href=\"https://doi.org/10.3934/dcds.2024114\">https://doi.org/10.3934/dcds.2024114</a>","ama":"Killip R, Ouyang Z, Vişan M, Wu L. The modified Korteweg–de Vries limit of the Ablowitz–Ladik system. <i>Discrete and Continuous Dynamical Systems</i>. 2025;45(3):821-846. doi:<a href=\"https://doi.org/10.3934/dcds.2024114\">10.3934/dcds.2024114</a>","ista":"Killip R, Ouyang Z, Vişan M, Wu L. 2025. The modified Korteweg–de Vries limit of the Ablowitz–Ladik system. Discrete and Continuous Dynamical Systems. 45(3), 821–846.","chicago":"Killip, Rowan, Zhimeng Ouyang, Monica Vişan, and Lei Wu. “The Modified Korteweg–de Vries Limit of the Ablowitz–Ladik System.” <i>Discrete and Continuous Dynamical Systems</i>. American Institute of Mathematical Sciences, 2025. <a href=\"https://doi.org/10.3934/dcds.2024114\">https://doi.org/10.3934/dcds.2024114</a>.","mla":"Killip, Rowan, et al. “The Modified Korteweg–de Vries Limit of the Ablowitz–Ladik System.” <i>Discrete and Continuous Dynamical Systems</i>, vol. 45, no. 3, American Institute of Mathematical Sciences, 2025, pp. 821–46, doi:<a href=\"https://doi.org/10.3934/dcds.2024114\">10.3934/dcds.2024114</a>.","ieee":"R. Killip, Z. Ouyang, M. Vişan, and L. Wu, “The modified Korteweg–de Vries limit of the Ablowitz–Ladik system,” <i>Discrete and Continuous Dynamical Systems</i>, vol. 45, no. 3. American Institute of Mathematical Sciences, pp. 821–846, 2025.","short":"R. Killip, Z. Ouyang, M. Vişan, L. Wu, Discrete and Continuous Dynamical Systems 45 (2025) 821–846."},"date_updated":"2026-06-30T07:34:20Z","publication_identifier":{"issn":["1078-0947"],"eissn":["1553-5231"]},"arxiv":1,"type":"journal_article","title":"The modified Korteweg–de Vries limit of the Ablowitz–Ladik system","year":"2025","oa":1,"publisher":"American Institute of Mathematical Sciences","page":"821-846","publication":"Discrete and Continuous Dynamical Systems","status":"public","OA_place":"repository","ddc":["500"],"quality_controlled":"1","external_id":{"arxiv":["2404.02366"]},"das_tickbox":"1","OA_type":"green","_id":"22069","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2404.02366"}],"date_created":"2026-06-19T08:20:28Z","day":"01","issue":"3","mathsc":["37J70","37K10","37K60","35Q53","35Q55"],"intvolume":"        45","publication_status":"published"},{"das_tickbox":"1","quality_controlled":"1","external_id":{"arxiv":["2405.01246"]},"_id":"22083","article_processing_charge":"No","OA_type":"green","publisher":"IOP Publishing","oa":1,"OA_place":"repository","publication":"Nonlinearity","status":"public","publication_status":"published","intvolume":"        38","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2405.01246"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"9","date_created":"2026-06-19T08:27:54Z","day":"15","scopus_import":"1","doi":"10.1088/1361-6544/ae022e","month":"09","volume":38,"date_published":"2025-09-15T00:00:00Z","article_type":"original","extern":"1","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1361-6544"],"issn":["0951-7715"]},"arxiv":1,"type":"journal_article","date_updated":"2026-07-01T07:17:44Z","year":"2025","title":"The nonlinear Schrödinger equation with sprinkled nonlinearity","author":[{"full_name":"Harrop-Griffiths, Benjamin","last_name":"Harrop-Griffiths","first_name":"Benjamin"},{"full_name":"Killip, Rowan","first_name":"Rowan","last_name":"Killip"},{"last_name":"Visan","first_name":"Monica","id":"056daca0-b8d1-11f0-964f-f91054abf8ca","full_name":"Visan, Monica"}],"oa_version":"Preprint","abstract":[{"text":"We prove global well-posedness for the cubic nonlinear Schrödinger equation with nonlinearity concentrated on a homogeneous Poisson process.","lang":"eng"}],"citation":{"ama":"Harrop-Griffiths B, Killip R, Vişan M. The nonlinear Schrödinger equation with sprinkled nonlinearity. <i>Nonlinearity</i>. 2025;38(9). doi:<a href=\"https://doi.org/10.1088/1361-6544/ae022e\">10.1088/1361-6544/ae022e</a>","apa":"Harrop-Griffiths, B., Killip, R., &#38; Vişan, M. (2025). The nonlinear Schrödinger equation with sprinkled nonlinearity. <i>Nonlinearity</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1361-6544/ae022e\">https://doi.org/10.1088/1361-6544/ae022e</a>","short":"B. Harrop-Griffiths, R. Killip, M. Vişan, Nonlinearity 38 (2025).","ista":"Harrop-Griffiths B, Killip R, Vişan M. 2025. The nonlinear Schrödinger equation with sprinkled nonlinearity. Nonlinearity. 38(9), 095020.","chicago":"Harrop-Griffiths, Benjamin, Rowan Killip, and Monica Vişan. “The Nonlinear Schrödinger Equation with Sprinkled Nonlinearity.” <i>Nonlinearity</i>. IOP Publishing, 2025. <a href=\"https://doi.org/10.1088/1361-6544/ae022e\">https://doi.org/10.1088/1361-6544/ae022e</a>.","mla":"Harrop-Griffiths, Benjamin, et al. “The Nonlinear Schrödinger Equation with Sprinkled Nonlinearity.” <i>Nonlinearity</i>, vol. 38, no. 9, 095020, IOP Publishing, 2025, doi:<a href=\"https://doi.org/10.1088/1361-6544/ae022e\">10.1088/1361-6544/ae022e</a>.","ieee":"B. Harrop-Griffiths, R. Killip, and M. Vişan, “The nonlinear Schrödinger equation with sprinkled nonlinearity,” <i>Nonlinearity</i>, vol. 38, no. 9. IOP Publishing, 2025."},"article_number":"095020"},{"date_published":"2025-05-14T00:00:00Z","oa":1,"publisher":"European Geosciences Union","has_accepted_license":"1","department":[{"_id":"FrPe"},{"_id":"GradSch"}],"publication":"EGU General Assembly 2025","status":"public","language":[{"iso":"eng"}],"OA_place":"publisher","ddc":["550"],"_id":"22120","article_processing_charge":"No","doi":"10.5194/egusphere-egu25-17446","OA_type":"gold","month":"05","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","conference":{"name":"EGU General Assembly","end_date":"2025-05-02","start_date":"2025-04-27","location":"Vienna, Austria & Virtual"},"oa_version":"Published Version","author":[{"last_name":"Muñoz Hermosilla","orcid":"0000-0002-1990-8508","first_name":"José M","id":"e1037a6d-646e-11ef-b402-e0ed9ab0901e","full_name":"Muñoz Hermosilla, José M"},{"first_name":"Evan","last_name":"Miles","full_name":"Miles, Evan"},{"full_name":"McCarthy, Michael","id":"22a2674a-61ce-11ee-94b5-d18813baf16f","first_name":"Michael","last_name":"McCarthy"},{"full_name":"Hardmeier, Florian","last_name":"Hardmeier","first_name":"Florian"},{"last_name":"Melo Velasco","first_name":"Juan Vicente","id":"2611dec0-b9c6-11ed-9bea-a81c2b17a549","full_name":"Melo Velasco, Juan Vicente"},{"first_name":"Guillaume","last_name":"Jouvet","full_name":"Jouvet, Guillaume"},{"first_name":"Francesca","orcid":"0000-0002-5554-8087","last_name":"Pellicciotti","full_name":"Pellicciotti, Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5194/egusphere-egu25-17446"}],"date_created":"2026-06-22T12:17:47Z","day":"14","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_number":"EGU25-17446","citation":{"short":"J.M. Muñoz Hermosilla, E. Miles, M. McCarthy, F. Hardmeier, J.V. Melo Velasco, G. Jouvet, F. Pellicciotti, in:, EGU General Assembly 2025, European Geosciences Union, 2025.","ista":"Muñoz Hermosilla JM, Miles E, McCarthy M, Hardmeier F, Melo Velasco JV, Jouvet G, Pellicciotti F. 2025. Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier. EGU General Assembly 2025. EGU General Assembly, EGU25-17446.","chicago":"Muñoz Hermosilla, José M, Evan Miles, Michael McCarthy, Florian Hardmeier, Juan Vicente Melo Velasco, Guillaume Jouvet, and Francesca Pellicciotti. “Towards Reconstructing Debris Supply to Reproduce the Historic Changes in Debris Extent at a Swiss Glacier.” In <i>EGU General Assembly 2025</i>. European Geosciences Union, 2025. <a href=\"https://doi.org/10.5194/egusphere-egu25-17446\">https://doi.org/10.5194/egusphere-egu25-17446</a>.","ieee":"J. M. Muñoz Hermosilla <i>et al.</i>, “Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier,” in <i>EGU General Assembly 2025</i>, Vienna, Austria &#38; Virtual, 2025.","mla":"Muñoz Hermosilla, José M., et al. “Towards Reconstructing Debris Supply to Reproduce the Historic Changes in Debris Extent at a Swiss Glacier.” <i>EGU General Assembly 2025</i>, EGU25-17446, European Geosciences Union, 2025, doi:<a href=\"https://doi.org/10.5194/egusphere-egu25-17446\">10.5194/egusphere-egu25-17446</a>.","ama":"Muñoz Hermosilla JM, Miles E, McCarthy M, et al. Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier. In: <i>EGU General Assembly 2025</i>. European Geosciences Union; 2025. doi:<a href=\"https://doi.org/10.5194/egusphere-egu25-17446\">10.5194/egusphere-egu25-17446</a>","apa":"Muñoz Hermosilla, J. M., Miles, E., McCarthy, M., Hardmeier, F., Melo Velasco, J. V., Jouvet, G., &#38; Pellicciotti, F. (2025). Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier. In <i>EGU General Assembly 2025</i>. Vienna, Austria &#38; Virtual: European Geosciences Union. <a href=\"https://doi.org/10.5194/egusphere-egu25-17446\">https://doi.org/10.5194/egusphere-egu25-17446</a>"},"date_updated":"2026-07-02T06:41:43Z","type":"conference_abstract","title":"Towards reconstructing debris supply to reproduce the historic changes in debris extent at a Swiss glacier","publication_status":"published","year":"2025"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://doi.org/10.4171/JEMS/1692","open_access":"1"}],"date_created":"2026-02-17T07:41:59Z","day":"02","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"DOAJ_listed":"1","publication_status":"epub_ahead","oa":1,"department":[{"_id":"MaKw"}],"publisher":"EMS Press","status":"public","publication":"Journal of the European Mathematical Society","OA_place":"publisher","quality_controlled":"1","external_id":{"arxiv":["2303.05435"]},"ddc":["510"],"das_tickbox":"1","acknowledgement":"We would like to thank Noga Alon for suggesting that our main result gives\r\na linear-time algorithm for computing the rank. We also thank the referees for a number of thoughtful comments and suggestions. Glasgow was supported by NSF graduate research fellowship program award DGE1656518. Kwan was supported by ERC Starting Grant “RANDSTRUCT” No. 101076777. Sah and Sawhney were supported by NSF Graduate Research Fellowship Program DGE-1745302.\r\n","_id":"21263","article_processing_charge":"No","OA_type":"diamond","oa_version":"Published Version","author":[{"first_name":"Margalit","last_name":"Glasgow","full_name":"Glasgow, Margalit"},{"id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","full_name":"Kwan, Matthew Alan","last_name":"Kwan","orcid":"0000-0002-4003-7567","first_name":"Matthew Alan"},{"last_name":"Sah","first_name":"Ashwin","full_name":"Sah, Ashwin"},{"full_name":"Sawhney, Mehtaab","last_name":"Sawhney","first_name":"Mehtaab"}],"citation":{"apa":"Glasgow, M., Kwan, M. A., Sah, A., &#38; Sawhney, M. (2025). The exact rank of sparse random graphs. <i>Journal of the European Mathematical Society</i>. EMS Press. <a href=\"https://doi.org/10.4171/jems/1692\">https://doi.org/10.4171/jems/1692</a>","ama":"Glasgow M, Kwan MA, Sah A, Sawhney M. The exact rank of sparse random graphs. <i>Journal of the European Mathematical Society</i>. 2025. doi:<a href=\"https://doi.org/10.4171/jems/1692\">10.4171/jems/1692</a>","chicago":"Glasgow, Margalit, Matthew Alan Kwan, Ashwin Sah, and Mehtaab Sawhney. “The Exact Rank of Sparse Random Graphs.” <i>Journal of the European Mathematical Society</i>. EMS Press, 2025. <a href=\"https://doi.org/10.4171/jems/1692\">https://doi.org/10.4171/jems/1692</a>.","ista":"Glasgow M, Kwan MA, Sah A, Sawhney M. 2025. The exact rank of sparse random graphs. Journal of the European Mathematical Society.","ieee":"M. Glasgow, M. A. Kwan, A. Sah, and M. Sawhney, “The exact rank of sparse random graphs,” <i>Journal of the European Mathematical Society</i>. EMS Press, 2025.","mla":"Glasgow, Margalit, et al. “The Exact Rank of Sparse Random Graphs.” <i>Journal of the European Mathematical Society</i>, EMS Press, 2025, doi:<a href=\"https://doi.org/10.4171/jems/1692\">10.4171/jems/1692</a>.","short":"M. Glasgow, M.A. Kwan, A. Sah, M. Sawhney, Journal of the European Mathematical Society (2025)."},"abstract":[{"lang":"eng","text":"Two landmark results in combinatorial random matrix theory, due to Komlós and Costello–Tao–Vu, show that discrete random matrices and symmetric discrete random matrices are typically nonsingular. In particular, in the language of graph theory, when p is a fixed constant, the biadjacency matrix of a random Erdős–Rényi bipartite graph G(n,n,p) and the adjacency matrix of an Erdős–Rényi random graph G(n,p) are both nonsingular with high probability. However, very sparse random graphs (i.e., where p is allowed to decay rapidly with n) are typically singular, due to the presence of “local” dependencies such as isolated vertices and pairs of degree-1 vertices with the same neighbour. In this paper, we give a combinatorial description of the rank of a sparse random graph G(n,n,c/n) or G(n,c/n) in terms of such local dependencies, for all constants c=e (and we present some evidence that the situation is very different for c=e). This gives an essentially complete answer to a question raised by Vu (2014). As applications of our main theorem and its proof, we also determine the asymptotic singularity probability of the 2-core of a sparse random graph, we show that the rank of a sparse random graph is extremely well approximated by its matching number, and we deduce a central limit theorem for the rank of G(n,c/n)."}],"date_updated":"2026-07-06T11:51:31Z","type":"journal_article","arxiv":1,"publication_identifier":{"issn":["1435-9855"],"eissn":["1435-9863"]},"title":"The exact rank of sparse random graphs","year":"2025","PlanS_conform":"1","date_published":"2025-09-02T00:00:00Z","corr_author":"1","project":[{"name":"Randomness and structure in combinatorics","grant_number":"101076777","_id":"bd95085b-d553-11ed-ba76-e55d3349be45"}],"has_accepted_license":"1","language":[{"iso":"eng"}],"article_type":"original","doi":"10.4171/jems/1692","month":"09"},{"department":[{"_id":"GradSch"},{"_id":"EdHa"},{"_id":"MiSi"},{"_id":"NanoFab"},{"_id":"AnSa"}],"oa":1,"OA_place":"repository","publication":"bioRxiv","status":"public","das_tickbox":"1","ddc":["539","570"],"article_processing_charge":"No","_id":"21427","acknowledgement":"European Research Council, https://ror.org/0472cxd90, 101071793\r\nAustrian Academy of Sciences, 26360","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.05.20.655037"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"day":"25","date_created":"2026-03-11T08:40:06Z","publication_status":"draft","has_accepted_license":"1","project":[{"_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd","grant_number":"101071793","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces"},{"_id":"34d75525-11ca-11ed-8bc3-89b6307fee9d","grant_number":"26360","name":"Motile active matter models of migrating cells and chiral filaments"}],"corr_author":"1","date_published":"2025-09-25T00:00:00Z","language":[{"iso":"eng"}],"doi":"10.1101/2025.05.20.655037","month":"09","author":[{"first_name":"Zuzana","last_name":"Dunajova","full_name":"Dunajova, Zuzana","id":"4B39F286-F248-11E8-B48F-1D18A9856A87"},{"id":"4323B49C-F248-11E8-B48F-1D18A9856A87","full_name":"Tasciyan, Saren","last_name":"Tasciyan","first_name":"Saren","orcid":"0000-0003-1671-393X"},{"last_name":"Majek","first_name":"Juraj","id":"3e6d9473-f38e-11ec-8ae0-c4e05a8aa9e1","full_name":"Majek, Juraj"},{"last_name":"Merrin","first_name":"Jack","orcid":"0000-0001-5145-4609","id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack"},{"full_name":"Sahai, Erik","first_name":"Erik","last_name":"Sahai"},{"last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K"},{"orcid":"0000-0001-6005-1561","first_name":"Edouard B","last_name":"Hannezo","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"oa_version":"Preprint","abstract":[{"text":"While tumor malignancy has been extensively studied under the prism of genetic and epigenetic heterogeneity, tumor cell states also critically depend on reciprocal interactions with the microenvironment. This raises the hitherto untested possibility that heterogeneity of the untransformed tumor stroma can actively fuel malignant progression. As biological heterogeneity is inherently difficult to control, we adopted a reductionist approach and let tumor cells invade micro-engineered environments harboring obstacles with precision-controlled geometry. We find that not only the presence of obstacles, but more surprisingly their spatial disorder, causes a drastic shift from a collective to a single-cell mode of invasion – comparable in strength to cadherin loss. Combining live-imaging and perturbation experiments with minimal biophysical modeling, we demonstrate that cell detachments result both from local geometrical constraints and a global integration of spatial disorder over time. We show that different types of microenvironments map onto different universality classes of invasion dynamics - homogeneous substrates follow Kardar–Parisi–Zhang (KPZ) scaling, while disordered ones exhibit exponents consistent with KPZ with quenched disorder (KPZq). Our findings highlight generic physical principles for how the mode of cancer cell invasion depends on environmental heterogeneity, with potential implications to understand tumor evolution in vivo.","lang":"eng"}],"citation":{"ama":"Dunajova Z, Tasciyan S, Majek J, et al. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2025.05.20.655037\">10.1101/2025.05.20.655037</a>","apa":"Dunajova, Z., Tasciyan, S., Majek, J., Merrin, J., Sahai, E., Sixt, M. K., &#38; Hannezo, E. B. (n.d.). Substrate heterogeneity promotes cancer cell dissemination through interface roughening. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2025.05.20.655037\">https://doi.org/10.1101/2025.05.20.655037</a>","short":"Z. Dunajova, S. Tasciyan, J. Majek, J. Merrin, E. Sahai, M.K. Sixt, E.B. Hannezo, BioRxiv (n.d.).","ieee":"Z. Dunajova <i>et al.</i>, “Substrate heterogeneity promotes cancer cell dissemination through interface roughening,” <i>bioRxiv</i>. .","mla":"Dunajova, Zuzana, et al. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2025.05.20.655037\">10.1101/2025.05.20.655037</a>.","chicago":"Dunajova, Zuzana, Saren Tasciyan, Juraj Majek, Jack Merrin, Erik Sahai, Michael K Sixt, and Edouard B Hannezo. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2025.05.20.655037\">https://doi.org/10.1101/2025.05.20.655037</a>.","ista":"Dunajova Z, Tasciyan S, Majek J, Merrin J, Sahai E, Sixt MK, Hannezo EB. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. bioRxiv, <a href=\"https://doi.org/10.1101/2025.05.20.655037\">10.1101/2025.05.20.655037</a>."},"type":"preprint","date_updated":"2026-07-06T12:38:17Z","year":"2025","related_material":{"record":[{"id":"21423","relation":"dissertation_contains","status":"public"},{"status":"public","relation":"research_data","id":"21439"}]},"title":"Substrate heterogeneity promotes cancer cell dissemination through interface roughening"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"issue":"22","date_created":"2025-11-19T09:44:31Z","day":"30","pmid":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"publication_status":"published","intvolume":"       188","department":[{"_id":"JiFr"},{"_id":"XiFe"}],"page":"6138-6150.e17","publisher":"Elsevier","file":[{"success":1,"date_created":"2025-11-24T10:55:18Z","file_size":17825465,"checksum":"8ac396a0806ad7f2e4e7a0c1eed712ce","file_name":"2025_Cell_Rodriguez.pdf","date_updated":"2025-11-24T10:55:18Z","content_type":"application/pdf","access_level":"open_access","creator":"dernst","file_id":"20679","relation":"main_file"}],"oa":1,"OA_place":"publisher","status":"public","publication":"Cell","quality_controlled":"1","external_id":{"pmid":["41043433"],"isi":["001616077900005"]},"ddc":["580"],"isi":1,"article_processing_charge":"Yes (via OA deal)","_id":"20656","OA_type":"hybrid","acknowledgement":"We gratefully acknowledge Tongda Xu for experimental, material, and conceptual support. We thank William Gray for providing material, Nataliia Gnyliukh and Ema Cervenova for help with manuscript preparation, and Julia Schmid for help with cloning. We thank Dolf Weijers, Mark Roosjen, and Andre Kuhn for discussions and support with phospho-proteomic analyses. We thank the Bioimaging and Life Science facilities at the Institute of Science and Technology Austria (ISTA) for their excellent service and assistance. The research leading to these results has received funding from the European Union (ERC, CYNIPS, 101142681) and Austrian Science Fund (FWF; I 6123-B) to J.F., and Y.J. was funded by ERC no. 3363360-APPL under FP/2007-2013. L.R. was supported by the FP7-PEOPLE-2011-COFUND ISTFELLOW program (IC1023FELL01) and the European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 985-2016). S.T. was supported by the National Natural Science Foundation of China (32321001, 32570366). The work of J.H. was supported by the project JG_2024_003 implemented within the Palacký University Young Researcher Grant.","author":[{"id":"3922B506-F248-11E8-B48F-1D18A9856A87","full_name":"Rodriguez Solovey, Lesia","last_name":"Rodriguez Solovey","orcid":"0000-0002-7244-7237","first_name":"Lesia"},{"id":"7c417475-8972-11ed-ae7b-8b674ca26986","full_name":"Fiedler, Lukas","last_name":"Fiedler","first_name":"Lukas"},{"first_name":"Minxia","last_name":"Zou","full_name":"Zou, Minxia","id":"5c243f41-03f3-11ec-841c-96faf48a7ef9"},{"first_name":"Caterina","last_name":"Giannini","full_name":"Giannini, Caterina","id":"e3fdddd5-f6e0-11ea-865d-ca99ee6367f4"},{"id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","full_name":"Monzer, Aline","last_name":"Monzer","first_name":"Aline"},{"last_name":"Vladimirtsev","first_name":"Dmitrii","id":"60466724-5355-11ee-ae5a-fa55e8f99c3d","full_name":"Vladimirtsev, Dmitrii"},{"id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae","full_name":"Randuch, Marek","last_name":"Randuch","first_name":"Marek"},{"last_name":"Yu","first_name":"Yongfan","full_name":"Yu, Yongfan"},{"full_name":"Gelová, Zuzana","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","orcid":"0000-0003-4783-1752","first_name":"Zuzana","last_name":"Gelová"},{"full_name":"Verstraeten, Inge","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7241-2328","first_name":"Inge","last_name":"Verstraeten"},{"last_name":"Hajny","orcid":"0000-0003-2140-7195","first_name":"Jakub","id":"4800CC20-F248-11E8-B48F-1D18A9856A87","full_name":"Hajny, Jakub"},{"last_name":"Chen","first_name":"Meng","full_name":"Chen, Meng"},{"last_name":"Tan","orcid":"0000-0002-0471-8285","first_name":"Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","full_name":"Tan, Shutang"},{"last_name":"Hörmayer","orcid":"0000-0001-8295-2926","first_name":"Lukas","id":"2EEE7A2A-F248-11E8-B48F-1D18A9856A87","full_name":"Hörmayer, Lukas"},{"first_name":"Lanxin","orcid":"0000-0002-5607-272X","last_name":"Li","full_name":"Li, Lanxin","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Maria Mar","last_name":"Marques-Bueno","full_name":"Marques-Bueno, Maria Mar"},{"first_name":"Zainab","last_name":"Quddoos","full_name":"Quddoos, Zainab","id":"32ff3c64-04a0-11f0-a50f-d0c45bfac466"},{"id":"34F1AF46-F248-11E8-B48F-1D18A9856A87","full_name":"Molnar, Gergely","last_name":"Molnar","first_name":"Gergely"},{"first_name":"Ivan","last_name":"Kulich","full_name":"Kulich, Ivan","id":"57a1567c-8314-11eb-9063-c9ddc3451a54"},{"last_name":"Jaillais","first_name":"Yvon","full_name":"Jaillais, Yvon"},{"first_name":"Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"oa_version":"Published Version","citation":{"ista":"Rodriguez Solovey L, Fiedler L, Zou M, Giannini C, Monzer A, Vladimirtsev D, Randuch M, Yu Y, Gelová Z, Verstraeten I, Hajny J, Chen M, Tan S, Hörmayer L, Li L, Marques-Bueno MM, Quddoos Z, Molnar G, Kulich I, Jaillais Y, Friml J. 2025. ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. 188(22), 6138–6150.e17.","chicago":"Rodriguez Solovey, Lesia, Lukas Fiedler, Minxia Zou, Caterina Giannini, Aline Monzer, Dmitrii Vladimirtsev, Marek Randuch, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” <i>Cell</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.cell.2025.08.026\">https://doi.org/10.1016/j.cell.2025.08.026</a>.","ieee":"L. Rodriguez Solovey <i>et al.</i>, “ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism,” <i>Cell</i>, vol. 188, no. 22. Elsevier, p. 6138–6150.e17, 2025.","mla":"Rodriguez Solovey, Lesia, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” <i>Cell</i>, vol. 188, no. 22, Elsevier, 2025, p. 6138–6150.e17, doi:<a href=\"https://doi.org/10.1016/j.cell.2025.08.026\">10.1016/j.cell.2025.08.026</a>.","short":"L. Rodriguez Solovey, L. Fiedler, M. Zou, C. Giannini, A. Monzer, D. Vladimirtsev, M. Randuch, Y. Yu, Z. Gelová, I. Verstraeten, J. Hajny, M. Chen, S. Tan, L. Hörmayer, L. Li, M.M. Marques-Bueno, Z. Quddoos, G. Molnar, I. Kulich, Y. Jaillais, J. Friml, Cell 188 (2025) 6138–6150.e17.","apa":"Rodriguez Solovey, L., Fiedler, L., Zou, M., Giannini, C., Monzer, A., Vladimirtsev, D., … Friml, J. (2025). ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2025.08.026\">https://doi.org/10.1016/j.cell.2025.08.026</a>","ama":"Rodriguez Solovey L, Fiedler L, Zou M, et al. ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. <i>Cell</i>. 2025;188(22):6138-6150.e17. doi:<a href=\"https://doi.org/10.1016/j.cell.2025.08.026\">10.1016/j.cell.2025.08.026</a>"},"abstract":[{"text":"Phytohormone auxin and its directional transport mediate much of the remarkably plastic development of higher plants. Positive feedback between auxin signaling and transport is a prerequisite for (1) self-organizing processes, including vascular tissue formation, and (2) directional growth responses such as gravitropism. Here, we identify a mechanism by which auxin signaling directly targets PIN auxin transporters. Via the cell-surface AUXIN-BINDING PROTEIN1 (ABP1)-TRANSMEMBRANE KINASE 1 (TMK1) receptor module, auxin rapidly induces phosphorylation and thus stabilization of PIN2. Following gravistimulation, initial auxin asymmetry activates autophosphorylation of the TMK1 kinase. This induces TMK1 interaction with and phosphorylation of PIN2, stabilizing PIN2 at the lower root side, thus reinforcing asymmetric auxin flow for root bending. Upstream of TMK1 in this regulation, ABP1 acts redundantly with the root-expressed ABP1-LIKE 3 (ABL3) auxin receptor. Such positive feedback between cell-surface auxin signaling and PIN-mediated polar auxin transport is fundamental for robust root gravitropism and presumably for other self-organizing developmental phenomena.","lang":"eng"}],"type":"journal_article","publication_identifier":{"issn":["0092-8674"]},"date_updated":"2026-07-06T12:51:13Z","year":"2025","title":"ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism","related_material":{"record":[{"id":"19399","relation":"earlier_version","status":"public"}]},"corr_author":"1","file_date_updated":"2025-11-24T10:55:18Z","project":[{"name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681","_id":"8f347782-16d5-11f0-9cad-8c19706ee739"},{"name":"Peptide receptors for auxin canalization in Arabidopsis","grant_number":"I06123","_id":"bd76d395-d553-11ed-ba76-f678c14f9033"},{"_id":"26060676-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 985-2016","name":"Cell surface receptor complexes for auxin signaling in plants"},{"name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","call_identifier":"FP7"}],"has_accepted_license":"1","ec_funded":1,"PlanS_conform":"1","volume":188,"date_published":"2025-10-30T00:00:00Z","article_type":"original","language":[{"iso":"eng"}],"doi":"10.1016/j.cell.2025.08.026","month":"10"},{"title":"ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism","related_material":{"record":[{"relation":"later_version","status":"public","id":"20656"},{"relation":"dissertation_contains","status":"public","id":"19395"},{"id":"20364","relation":"dissertation_contains","status":"public"}]},"year":"2025","date_updated":"2026-07-06T12:51:14Z","type":"preprint","citation":{"short":"L. Rodriguez Solovey, L. Fiedler, M. Zou, C. Giannini, A. Monzer, D. Vladimirtsev, M. Randuch, Y. Yu, Z. Gelová, I. Verstraeten, J. Hajny, M. Chen, S. Tan, L. Hörmayer, L. Li, M.M. Marques-Bueno, Z. Quddoos, G. Molnar, T. Xu, I. Kulich, Y. Jaillais, J. Friml, BioRxiv (n.d.).","chicago":"Rodriguez Solovey, Lesia, Lukas Fiedler, Minxia Zou, Caterina Giannini, Aline Monzer, Dmitrii Vladimirtsev, Marek Randuch, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Directly Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2022.11.30.518503\">https://doi.org/10.1101/2022.11.30.518503</a>.","ista":"Rodriguez Solovey L, Fiedler L, Zou M, Giannini C, Monzer A, Vladimirtsev D, Randuch M, Yu Y, Gelová Z, Verstraeten I, Hajny J, Chen M, Tan S, Hörmayer L, Li L, Marques-Bueno MM, Quddoos Z, Molnar G, Xu T, Kulich I, Jaillais Y, Friml J. ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism. bioRxiv, <a href=\"https://doi.org/10.1101/2022.11.30.518503\">10.1101/2022.11.30.518503</a>.","mla":"Rodriguez Solovey, Lesia, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Directly Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2022.11.30.518503\">10.1101/2022.11.30.518503</a>.","ieee":"L. Rodriguez Solovey <i>et al.</i>, “ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism,” <i>bioRxiv</i>. .","ama":"Rodriguez Solovey L, Fiedler L, Zou M, et al. ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2022.11.30.518503\">10.1101/2022.11.30.518503</a>","apa":"Rodriguez Solovey, L., Fiedler, L., Zou, M., Giannini, C., Monzer, A., Vladimirtsev, D., … Friml, J. (n.d.). ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2022.11.30.518503\">https://doi.org/10.1101/2022.11.30.518503</a>"},"abstract":[{"lang":"eng","text":"Phytohormone auxin and its directional transport mediate much of the remarkably plastic development of higher plants. Positive feedback between auxin signaling and transport is a key prerequisite for (i) self-organizing processes including vascular tissue formation and (ii) directional growth responses such as gravitropism. Here we identify a mechanism, by which auxin signaling directly targets PIN auxin transporters. Via the cell-surface ABP1-TMK1 receptor module, auxin rapidly induces phosphorylation and thus stabilization of PIN2. Following gravistimulation, initial auxin asymmetry activates autophosphorylation of the TMK1 kinase. This induces TMK1 interaction with and phosphorylation of PIN2, stabilizing PIN2 at the lower root side, thus reinforcing asymmetric auxin flow for root bending. Upstream of TMK1 in this regulation, ABP1 acts redundantly with the root-expressed ABP1-LIKE auxin receptor ABL3. Such positive feedback between cell-surface auxin signaling and PIN-mediated polar auxin transport is fundamental for robust root gravitropism and presumably also for other self-organizing developmental phenomena."}],"oa_version":"Published Version","author":[{"id":"3922B506-F248-11E8-B48F-1D18A9856A87","full_name":"Rodriguez Solovey, Lesia","last_name":"Rodriguez Solovey","orcid":"0000-0002-7244-7237","first_name":"Lesia"},{"id":"7c417475-8972-11ed-ae7b-8b674ca26986","full_name":"Fiedler, Lukas","last_name":"Fiedler","first_name":"Lukas"},{"first_name":"Minxia","last_name":"Zou","full_name":"Zou, Minxia","id":"5c243f41-03f3-11ec-841c-96faf48a7ef9"},{"last_name":"Giannini","first_name":"Caterina","id":"e3fdddd5-f6e0-11ea-865d-ca99ee6367f4","full_name":"Giannini, Caterina"},{"id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","full_name":"Monzer, Aline","last_name":"Monzer","first_name":"Aline"},{"last_name":"Vladimirtsev","first_name":"Dmitrii","id":"60466724-5355-11ee-ae5a-fa55e8f99c3d","full_name":"Vladimirtsev, Dmitrii"},{"id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae","full_name":"Randuch, Marek","last_name":"Randuch","first_name":"Marek"},{"full_name":"Yu, Yongfan","last_name":"Yu","first_name":"Yongfan"},{"id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","full_name":"Gelová, Zuzana","last_name":"Gelová","first_name":"Zuzana","orcid":"0000-0003-4783-1752"},{"last_name":"Verstraeten","orcid":"0000-0001-7241-2328","first_name":"Inge","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87","full_name":"Verstraeten, Inge"},{"full_name":"Hajny, Jakub","id":"4800CC20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2140-7195","first_name":"Jakub","last_name":"Hajny"},{"full_name":"Chen, Meng","first_name":"Meng","last_name":"Chen"},{"first_name":"Shutang","orcid":"0000-0002-0471-8285","last_name":"Tan","full_name":"Tan, Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hörmayer, Lukas","id":"2EEE7A2A-F248-11E8-B48F-1D18A9856A87","first_name":"Lukas","orcid":"0000-0001-8295-2926","last_name":"Hörmayer"},{"last_name":"Li","orcid":"0000-0002-5607-272X","first_name":"Lanxin","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","full_name":"Li, Lanxin"},{"full_name":"Marques-Bueno, Maria Mar","last_name":"Marques-Bueno","first_name":"Maria Mar"},{"first_name":"Zainab","last_name":"Quddoos","full_name":"Quddoos, Zainab","id":"32ff3c64-04a0-11f0-a50f-d0c45bfac466"},{"first_name":"Gergely","last_name":"Molnar","full_name":"Molnar, Gergely","id":"34F1AF46-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Tongda","last_name":"Xu","full_name":"Xu, Tongda"},{"id":"57a1567c-8314-11eb-9063-c9ddc3451a54","full_name":"Kulich, Ivan","last_name":"Kulich","first_name":"Ivan"},{"last_name":"Jaillais","first_name":"Yvon","full_name":"Jaillais, Yvon"},{"full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml"}],"doi":"10.1101/2022.11.30.518503","month":"02","language":[{"iso":"eng"}],"ec_funded":1,"date_published":"2025-02-20T00:00:00Z","corr_author":"1","project":[{"call_identifier":"H2020","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985"},{"call_identifier":"FWF","name":"Molecular mechanisms of endocytic cargo recognition in plants","_id":"26538374-B435-11E9-9278-68D0E5697425","grant_number":"I03630"},{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"},{"name":"Cell surface receptor complexes for auxin signaling in plants","_id":"26060676-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 985-2016"}],"publication_status":"draft","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"day":"20","date_created":"2025-03-13T08:36:48Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://doi.org/10.1101/2022.11.30.518503","open_access":"1"}],"acknowledgement":"We thank W. Gray for providing material; N. Gnyliukh and E. Cervenova for help with manuscript preparation; J. Schmid for help with cloning. We thank Dolf Weijers, Mark Roosjen, and Andre Kuhn for discussions and support with phospho-proteomic analyses. We thank the Bioimaging and Life Science facilities at ISTA for their excellent service and assistance. The research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program grant agreement No 742985 and Austrian Science Fund (FWF): I3630-775 B25 to J.F; National Natural Science Foundation of China (Grant 32130010, 31422008), start-up funds from FAFU to T.X., Y.J. was funded by ERC no. 3363360-APPL under FP/2007-2013. L.R. was supported by FP7-PEOPLE-2011-COFUND ISTFELLOW program (IC1023FELL01) and the European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 985- 2016). S.T. was supported by the National Natural Science Foundation of China (32321001).","article_processing_charge":"No","_id":"19399","OA_type":"green","ddc":["580"],"das_tickbox":"1","status":"public","publication":"bioRxiv","OA_place":"repository","oa":1,"department":[{"_id":"JiFr"},{"_id":"XiFe"}]},{"acknowledgement":"Plant Facility,\r\nProtein Service Facility","article_processing_charge":"No","_id":"20364","ddc":["580"],"status":"public","alternative_title":["ISTA Thesis"],"OA_place":"publisher","file":[{"embargo_to":"open_access","file_name":"2025_Giannini_Caterina_Thesis...pdf","date_created":"2025-09-24T14:46:34Z","file_size":14278965,"checksum":"536ba1701453b0b2346be14c046b2911","access_level":"closed","date_updated":"2025-09-30T14:31:29Z","content_type":"application/pdf","creator":"cgiannin","file_id":"20390","relation":"main_file","embargo":"2026-09-30"},{"file_name":"2025_Giannini_Caterina_Thesis...docx","checksum":"192f55262f2da2ea0a59d9c23a1b8573","date_created":"2025-09-24T14:46:35Z","file_size":24499022,"relation":"source_file","file_id":"20391","creator":"cgiannin","access_level":"closed","date_updated":"2025-09-24T14:46:35Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document"}],"supervisor":[{"full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","first_name":"Jiří","last_name":"Friml"}],"department":[{"_id":"GradSch"},{"_id":"JiFr"},{"_id":"MaLo"}],"page":"151","publisher":"Institute of Science and Technology Austria","publication_status":"published","keyword":["Auxin Signaling","Plant Development"],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"day":"19","date_created":"2025-09-19T12:23:38Z","degree_awarded":"PhD","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","month":"09","doi":"10.15479/AT-ISTA-20364","language":[{"iso":"eng"}],"date_published":"2025-09-19T00:00:00Z","corr_author":"1","file_date_updated":"2025-09-30T14:31:29Z","has_accepted_license":"1","title":"Nuclear and cell surface auxin signaling in A. thaliana developmental transitions","related_material":{"record":[{"id":"12291","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"19399"}]},"year":"2025","date_updated":"2026-07-06T12:51:13Z","type":"dissertation","publication_identifier":{"issn":["2663-337X"]},"citation":{"apa":"Giannini, C. (2025). <i>Nuclear and cell surface auxin signaling in A. thaliana developmental transitions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20364\">https://doi.org/10.15479/AT-ISTA-20364</a>","ama":"Giannini C. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20364\">10.15479/AT-ISTA-20364</a>","chicago":"Giannini, Caterina. “Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20364\">https://doi.org/10.15479/AT-ISTA-20364</a>.","ista":"Giannini C. 2025. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. Institute of Science and Technology Austria.","ieee":"C. Giannini, “Nuclear and cell surface auxin signaling in A. thaliana developmental transitions,” Institute of Science and Technology Austria, 2025.","mla":"Giannini, Caterina. <i>Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20364\">10.15479/AT-ISTA-20364</a>.","short":"C. Giannini, Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions, Institute of Science and Technology Austria, 2025."},"oa_version":"Published Version","author":[{"last_name":"Giannini","first_name":"Caterina","id":"e3fdddd5-f6e0-11ea-865d-ca99ee6367f4","full_name":"Giannini, Caterina"}]},{"degree_awarded":"PhD","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_created":"2025-10-10T14:58:30Z","day":"12","tmp":{"name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","short":"CC BY-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","image":"/images/cc_by_sa.png"},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"publication_status":"published","file":[{"file_size":6846189,"date_created":"2025-10-28T13:10:08Z","checksum":"2892f04d4a5c18677871c3e06ac1244a","file_name":"Thesis_PDFA_.pdf","success":1,"creator":"snaik","relation":"main_file","file_id":"20567","date_updated":"2025-10-28T13:10:08Z","content_type":"application/pdf","access_level":"open_access"},{"file_name":"Thesis.zip","checksum":"15934d4465cd0e9b7c32678da9a33a2f","file_size":8839300,"date_created":"2025-10-28T13:10:26Z","access_level":"open_access","content_type":"application/zip","date_updated":"2025-10-28T13:10:26Z","file_id":"20568","relation":"source_file","creator":"snaik"}],"oa":1,"supervisor":[{"full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","last_name":"Heisenberg"},{"last_name":"Hannezo","first_name":"Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B"}],"department":[{"_id":"GradSch"},{"_id":"CaHe"},{"_id":"EdHa"}],"page":"105","publisher":"Institute of Science and Technology Austria","status":"public","alternative_title":["ISTA Thesis"],"OA_place":"publisher","ddc":["596","597","532"],"acknowledgement":"I would also like to thank the LSF and Cryo facility at ISTA, which have been helpful in my\r\nexperiments. I would also like to acknowledge FWF, grant DOI 10.55776/PAT5044023 and JKU Nanocell grant DOI \r\n10.55776/W1250 for providing funding for my PhD research. EMBO and FWF for providing funding for travel grants to attend conferences.","article_processing_charge":"No","_id":"20441","oa_version":"Published Version","author":[{"id":"2C0B105C-F248-11E8-B48F-1D18A9856A87","full_name":"Naik, Suyash","last_name":"Naik","orcid":"0000-0001-8421-5508","first_name":"Suyash"}],"citation":{"ama":"Naik S. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20441\">10.15479/AT-ISTA-20441</a>","apa":"Naik, S. (2025). <i>Keratins act as global coordinators of tissue spreading through mechanosensitive feedback</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20441\">https://doi.org/10.15479/AT-ISTA-20441</a>","short":"S. Naik, Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback, Institute of Science and Technology Austria, 2025.","ieee":"S. Naik, “Keratins act as global coordinators of tissue spreading through mechanosensitive feedback,” Institute of Science and Technology Austria, 2025.","mla":"Naik, Suyash. <i>Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20441\">10.15479/AT-ISTA-20441</a>.","chicago":"Naik, Suyash. “Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20441\">https://doi.org/10.15479/AT-ISTA-20441</a>.","ista":"Naik S. 2025. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. Institute of Science and Technology Austria."},"abstract":[{"text":"Epithelial spreading plays a pivotal role in the development of organisms especially those\r\nsuch as zebrafish which require the epithelial enveloping layer (EVL) to spread to cover the\r\nsubstantial yolk surface during gastrulation. Epiboly requires the transition of the epithelium\r\nwith cuboidal cells to form a thin, flat squamous epithelial sheet. During this transition, the\r\ncells show tissue-scale mechanosensation with mechanisms such as direct mechanical control\r\nover the axis of cell division.\r\nCytoskeletal intermediate filaments play a crucial role in vertebrate cells, not only facilitating\r\nmechanical stability but also helping facilitate the mechanosensitive response of the cell.\r\nMechanosenstivity displayed by intermediate filaments is due not just to their interesting\r\nphysical properties but also to their interactions with other cytoskeletal elements such as actin\r\nand microtubules. Keratin is the predominant intermediate filament expressed in the EVL.\r\nIt expresses concomitantly with the gastrulation movements of the developing embryo. Our\r\nwork focuses on understanding the role and dynamics of the keratin cytoskeletal network in\r\nmodulating the physical aspects of EVL spreading. We demonstrated with the combination of\r\nphysical characterisation and manipulations of the EVL, utilising a variety of biophysical tools\r\nand microscopy, the mechanistic role of keratin in tissue spreading.\r\nGenerating novel genetic morphants and mutants, we probe the effect that the loss of the\r\nkeratin network has on the physiology of the epithelium and the developing embryo. We\r\nshow that the changing organisation of the keratin network is important for changing EVL\r\nphysical properties as the stress imposed on the EVL increases during epiboly. By modelling\r\nthe epithelium, we study how the mechanical heterogeneity in an epithelium can feed back into\r\na mechanical loop to the maturation of the keratin network and hence affect the mechanics\r\nof the epithelium. However, unlike what would be predicted by the effect of intermediate\r\nfilaments in acting as a security belt and increasing the resistance of the epithelium, we observe\r\nthat loss of keratin leads to a delay in the EVL movement. Using both local aspirations of the\r\nYSL and EVL ablations, we demonstrate the mechanistic facilitation of actin mechanosensation\r\nin a keratin-dependent manner.\r\nFurthermore, using chemical inhibitors of microtubule polymerisation, we provide insight into\r\nthe mechanisms underlying the organisation and distribution of keratin. Interestingly, the\r\nphenotype observed upon this loss of microtubules shows that keratins interact with the nucleus\r\nthrough microtubular interactions. Together with these diverse observations, we describe\r\nthe mechanosensory feedback between resilience and that is critical for uniform and robust\r\nspreading of the epithelium.","lang":"eng"}],"date_updated":"2026-07-06T12:51:41Z","type":"dissertation","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-069-5"]},"title":"Keratins act as global coordinators of tissue spreading through mechanosensitive feedback","related_material":{"record":[{"id":"20465","status":"public","relation":"part_of_dissertation"}]},"year":"2025","date_published":"2025-10-12T00:00:00Z","corr_author":"1","project":[{"name":"Keratins in epithelial tissue spreading","grant_number":"PAT 5044023","_id":"8f060199-16d5-11f0-9cad-f3253b266c46"},{"call_identifier":"FWF","_id":"25AA5F24-B435-11E9-9278-68D0E5697425","grant_number":"W 1250-B20","name":"Nano-Analytics of Cellular Systems"}],"file_date_updated":"2025-10-28T13:10:26Z","has_accepted_license":"1","language":[{"iso":"eng"}],"license":"https://creativecommons.org/licenses/by-sa/4.0/","month":"10","doi":"10.15479/AT-ISTA-20441"},{"title":"Cell-Surface Auxin Signaling: Linking molecular pathways to plant development","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"12291"},{"relation":"part_of_dissertation","status":"public","id":"14826"},{"id":"19399","relation":"part_of_dissertation","status":"public"},{"id":"19398","status":"public","relation":"part_of_dissertation"}]},"year":"2025","date_updated":"2026-07-06T12:52:09Z","type":"dissertation","publication_identifier":{"eissn":["2663-337X"],"eisbn":["978-3-99078-054-1"]},"citation":{"ama":"Monzer A. Cell-Surface Auxin Signaling: Linking molecular pathways to plant development. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19395\">10.15479/AT-ISTA-19395</a>","apa":"Monzer, A. (2025). <i>Cell-Surface Auxin Signaling: Linking molecular pathways to plant development</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19395\">https://doi.org/10.15479/AT-ISTA-19395</a>","short":"A. Monzer, Cell-Surface Auxin Signaling: Linking Molecular Pathways to Plant Development, Institute of Science and Technology Austria, 2025.","ista":"Monzer A. 2025. Cell-Surface Auxin Signaling: Linking molecular pathways to plant development. Institute of Science and Technology Austria.","chicago":"Monzer, Aline. “Cell-Surface Auxin Signaling: Linking Molecular Pathways to Plant Development.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19395\">https://doi.org/10.15479/AT-ISTA-19395</a>.","mla":"Monzer, Aline. <i>Cell-Surface Auxin Signaling: Linking Molecular Pathways to Plant Development</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19395\">10.15479/AT-ISTA-19395</a>.","ieee":"A. Monzer, “Cell-Surface Auxin Signaling: Linking molecular pathways to plant development,” Institute of Science and Technology Austria, 2025."},"abstract":[{"text":"Plant growth and development rely significantly on phytohormones, with auxin serving as a master regulator, orchestrating processes from embryogenesis to organogenesis, vascular patterning, and environmental adaptation. Since its conceptual proposition by Charles Darwin in 1880 as an endogenous chemical signal influencing phototropism in grass, auxin has captivated scientists seeking to understand how such a small molecule exerts a profound influence on plant development.\r\nOne particularly fascinating aspect of auxin function is its ability to self-organize its transport. Through a feedback mechanism between auxin perception and directional transport—primarily mediated by PIN auxin transporters—auxin establishes narrow transport channels. This phenomenon, known as auxin canalization, is fundamental to vascular formation, regeneration, and other key developmental processes. Despite advances in our understanding, driven by experimental studies and computational models, auxin canalization remains an enigma, with many unanswered questions.\r\nLike other hormones, auxin functions through intricate signaling pathways. It operates through at least two distinct signaling mechanisms: the well-characterized canonical pathway and the less understood non-canonical pathway. While significant progress has been made in elucidating the canonical pathway, the non-canonical mechanisms remain less defined and require further investigation.\r\nIn this study, we revisit the non-canonical auxin signaling pathway mediated by the cell-surface complex Auxin Binding Protein 1-Transmembrane Kinase 1 (ABP1-TMK1), with a particular focus on its downstream phosphorylation events. We reveal that this auxin-mediated phosphorylation is conserved across the green lineage, underscoring its fundamental role in plant development. We explore key phosphorylation targets, particularly PIN2, which is essential for root gravitropism. To further understand TMK1’s role in diverse developmental processes, we identified and investigated its interactors as potential co-receptors or regulatory components within its signaling network.\r\nGiven the previously established role of ABP1-TMK1 in auxin canalization, we sought to further investigate this process and identified several TMK1 interactors also involved in this intricate mechanism.\r\nThese findings provide new insights into the complex regulation of auxin canalization, highlighting a broader and more interconnected signaling framework than previously understood.","lang":"eng"}],"oa_version":"Published Version","author":[{"last_name":"Monzer","first_name":"Aline","id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","full_name":"Monzer, Aline"}],"doi":"10.15479/AT-ISTA-19395","month":"03","language":[{"iso":"eng"}],"date_published":"2025-03-13T00:00:00Z","corr_author":"1","file_date_updated":"2025-04-01T07:55:27Z","has_accepted_license":"1","publication_status":"published","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"day":"13","date_created":"2025-03-12T14:25:42Z","degree_awarded":"PhD","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","acknowledgement":"I would like to acknowledge the facilities at ISTA, particularly LSF, IOF, and, of course, the plant facility, for providing the necessary resources for my research.","article_processing_charge":"No","_id":"19395","ddc":["580"],"alternative_title":["ISTA Thesis"],"status":"public","OA_place":"publisher","file":[{"access_level":"open_access","date_updated":"2025-03-12T14:14:49Z","content_type":"application/pdf","creator":"amonzer","relation":"main_file","file_id":"19396","success":1,"file_name":"Final Thesis Aline Monzer.pdf","file_size":13119670,"date_created":"2025-03-12T14:14:49Z","checksum":"9a3dd03bb4ec6b9907a325c3c4e8a1d7"},{"date_created":"2025-03-12T14:15:19Z","file_size":13774837,"checksum":"a353ce1ee2eabce37bca35499e76dbf1","file_name":"Thesis Aline.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_updated":"2025-04-01T07:55:27Z","access_level":"closed","creator":"amonzer","file_id":"19397","relation":"source_file"}],"oa":1,"supervisor":[{"first_name":"Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"department":[{"_id":"GradSch"},{"_id":"JiFr"}],"page":"160","publisher":"Institute of Science and Technology Austria"},{"year":"2025","title":"TMK interacting network of receptor like kinases for auxin canalization and beyond","related_material":{"record":[{"id":"19395","relation":"dissertation_contains","status":"public"}]},"type":"preprint","date_updated":"2026-07-06T12:52:09Z","citation":{"short":"A. Monzer, E. Mazur, L. Rodriguez Solovey, M.C. Gallei, M. Zou, M. Smejkal, E. Cervenova, J. Friml, BioRxiv (n.d.).","chicago":"Monzer, Aline, Ewa Mazur, Lesia Rodriguez Solovey, Michelle C Gallei, Minxia Zou, Michael Smejkal, Ema Cervenova, and Jiří Friml. “TMK Interacting Network of Receptor like Kinases for Auxin Canalization and Beyond.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2025.02.28.640727\">https://doi.org/10.1101/2025.02.28.640727</a>.","ista":"Monzer A, Mazur E, Rodriguez Solovey L, Gallei MC, Zou M, Smejkal M, Cervenova E, Friml J. TMK interacting network of receptor like kinases for auxin canalization and beyond. bioRxiv, <a href=\"https://doi.org/10.1101/2025.02.28.640727\">10.1101/2025.02.28.640727</a>.","mla":"Monzer, Aline, et al. “TMK Interacting Network of Receptor like Kinases for Auxin Canalization and Beyond.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2025.02.28.640727\">10.1101/2025.02.28.640727</a>.","ieee":"A. Monzer <i>et al.</i>, “TMK interacting network of receptor like kinases for auxin canalization and beyond,” <i>bioRxiv</i>. .","ama":"Monzer A, Mazur E, Rodriguez Solovey L, et al. TMK interacting network of receptor like kinases for auxin canalization and beyond. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2025.02.28.640727\">10.1101/2025.02.28.640727</a>","apa":"Monzer, A., Mazur, E., Rodriguez Solovey, L., Gallei, M. C., Zou, M., Smejkal, M., … Friml, J. (n.d.). TMK interacting network of receptor like kinases for auxin canalization and beyond. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2025.02.28.640727\">https://doi.org/10.1101/2025.02.28.640727</a>"},"abstract":[{"lang":"eng","text":"Receptor-like kinases (RLKs), particularly the Transmembrane Kinase (TMK) family, play essential roles in signaling and development, with TMKs being key components of auxin perception and downstream phosphorylation events. While TMKs’ involvement in auxin canalization, a process essential for vasculature formation and regeneration, has been established, nonetheless, the additional signaling and regulatory partners remain poorly understood. In this study, we identify and characterize seven leucine-rich repeat RLKs (TINT1–TINT7) as novel interactors of TMK1, revealing their diverse evolutionary, structural, and functional characteristics. Our results show that TINTs interact with TMK1 and highlight their roles in regulating various developmental processes. Majority of TINTs contributes, together with TMK1, to auxin canalization, with TINT5 linking TMK1 to other canalization component CAMEL. Beyond canalization, we also establish the role of TINT-TMK1 interactions in processes such as stomatal movement and the hypocotyl’s gravitropic response. These findings suggest that TINTs, through their interaction with TMK1, are integral components of various signaling networks, contributing to both auxin canalization and broader plant development."}],"author":[{"last_name":"Monzer","first_name":"Aline","id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","full_name":"Monzer, Aline"},{"last_name":"Mazur","first_name":"Ewa","full_name":"Mazur, Ewa"},{"last_name":"Rodriguez Solovey","first_name":"Lesia","orcid":"0000-0002-7244-7237","id":"3922B506-F248-11E8-B48F-1D18A9856A87","full_name":"Rodriguez Solovey, Lesia"},{"id":"35A03822-F248-11E8-B48F-1D18A9856A87","full_name":"Gallei, Michelle C","last_name":"Gallei","first_name":"Michelle C","orcid":"0000-0003-1286-7368"},{"full_name":"Zou, Minxia","id":"5c243f41-03f3-11ec-841c-96faf48a7ef9","first_name":"Minxia","last_name":"Zou"},{"full_name":"Smejkal, Michael","id":"79a5a1be-04a3-11f0-ba18-a1730e0b58e9","first_name":"Michael","last_name":"Smejkal"},{"first_name":"Ema","last_name":"Cervenova","full_name":"Cervenova, Ema","id":"9f185b95-04a3-11f0-8245-f5e32eeb470f"},{"last_name":"Friml","first_name":"Jiří","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří"}],"oa_version":"Published Version","month":"03","doi":"10.1101/2025.02.28.640727","language":[{"iso":"eng"}],"corr_author":"1","has_accepted_license":"1","date_published":"2025-03-02T00:00:00Z","publication_status":"draft","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"date_created":"2025-03-12T14:28:53Z","day":"02","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.02.28.640727"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"19398","article_processing_charge":"No","OA_type":"green","acknowledgement":"We deeply appreciate M. Wrzaczek’s constructive input and insightful discussions, which significantly enriched this work. We thank L. Fiedler for helping with the heat map and for the discussions. We also thank the facilities at ISTA, the imaging and optics (IOF) and Lab Support (LSF) facilities for their service and assistance.","das_tickbox":"1","ddc":["580"],"OA_place":"repository","status":"public","publication":"bioRxiv","department":[{"_id":"GradSch"},{"_id":"JiFr"},{"_id":"EvBe"}],"oa":1},{"publication_status":"published","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"day":"04","date_created":"2025-04-04T07:48:24Z","degree_awarded":"PhD","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"19478","article_processing_charge":"No","acknowledgement":"This project was funded by the European Research Council Advanced Grant (ETAP-742985),\r\nEuropean Research Council (ERC; 101142681 CYNIPS), Austrian Science Fund (FWF; P\r\n37051-B).","ddc":["580"],"OA_place":"publisher","status":"public","alternative_title":["ISTA Thesis"],"department":[{"_id":"GradSch"},{"_id":"JiFr"}],"page":"118","publisher":"Institute of Science and Technology Austria","file":[{"access_level":"closed","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_updated":"2025-04-08T08:22:37Z","creator":"hchen","file_id":"19526","relation":"source_file","file_name":"Thesis_0403_Huihuang.docx","date_created":"2025-04-08T08:00:07Z","file_size":16344814,"checksum":"b154973663a1bba505683faab7ae5ead"},{"embargo_to":"local","date_created":"2025-04-08T08:00:06Z","file_size":8482147,"checksum":"0099565f024388830c125ec17375c1a0","file_name":"Thesis_0406_PDFA_Huihuang_1.pdf","content_type":"application/pdf","date_updated":"2025-04-09T13:53:38Z","access_level":"closed","embargo":"2026-10-08","creator":"hchen","relation":"main_file","file_id":"19527"}],"supervisor":[{"orcid":"0000-0002-8302-7596","first_name":"Jiří","last_name":"Friml","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"year":"2025","title":"The cAMP second messenger in auxin signalling","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"19421"},{"id":"13212","relation":"part_of_dissertation","status":"public"}]},"type":"dissertation","publication_identifier":{"issn":["2663-337X"]},"date_updated":"2026-07-06T12:58:58Z","citation":{"ama":"Chen H. The cAMP second messenger in auxin signalling. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19478\">10.15479/AT-ISTA-19478</a>","apa":"Chen, H. (2025). <i>The cAMP second messenger in auxin signalling</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19478\">https://doi.org/10.15479/AT-ISTA-19478</a>","short":"H. Chen, The CAMP Second Messenger in Auxin Signalling, Institute of Science and Technology Austria, 2025.","mla":"Chen, Huihuang. <i>The CAMP Second Messenger in Auxin Signalling</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19478\">10.15479/AT-ISTA-19478</a>.","ieee":"H. Chen, “The cAMP second messenger in auxin signalling,” Institute of Science and Technology Austria, 2025.","chicago":"Chen, Huihuang. “The CAMP Second Messenger in Auxin Signalling.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19478\">https://doi.org/10.15479/AT-ISTA-19478</a>.","ista":"Chen H. 2025. The cAMP second messenger in auxin signalling. Institute of Science and Technology Austria."},"author":[{"full_name":"Chen, Huihuang","id":"83c96512-15b2-11ec-abd3-b7eede36184f","first_name":"Huihuang","last_name":"Chen"}],"oa_version":"Published Version","month":"04","doi":"10.15479/AT-ISTA-19478","language":[{"iso":"eng"}],"corr_author":"1","file_date_updated":"2025-04-09T13:53:38Z","has_accepted_license":"1","project":[{"call_identifier":"H2020","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","name":"Tracing Evolution of Auxin Transport and Polarity in Plants"},{"name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors","grant_number":"P37051","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6"},{"name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681","_id":"8f347782-16d5-11f0-9cad-8c19706ee739"}],"ec_funded":1,"date_published":"2025-04-04T00:00:00Z"},{"author":[{"orcid":"0000-0003-2027-5549","first_name":"Charlotte","last_name":"Hoffmann","full_name":"Hoffmann, Charlotte","id":"0f78d746-dc7d-11ea-9b2f-83f92091afe7"}],"oa_version":"Published Version","citation":{"short":"C. Hoffmann, Theory and Applications of Verifiable Delay Functions, Institute of Science and Technology Austria, 2025.","chicago":"Hoffmann, Charlotte. “Theory and Applications of Verifiable Delay Functions.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20920\">https://doi.org/10.15479/AT-ISTA-20920</a>.","ista":"Hoffmann C. 2025. Theory and applications of verifiable delay functions. Institute of Science and Technology Austria.","ieee":"C. Hoffmann, “Theory and applications of verifiable delay functions,” Institute of Science and Technology Austria, 2025.","mla":"Hoffmann, Charlotte. <i>Theory and Applications of Verifiable Delay Functions</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20920\">10.15479/AT-ISTA-20920</a>.","ama":"Hoffmann C. Theory and applications of verifiable delay functions. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20920\">10.15479/AT-ISTA-20920</a>","apa":"Hoffmann, C. (2025). <i>Theory and applications of verifiable delay functions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20920\">https://doi.org/10.15479/AT-ISTA-20920</a>"},"abstract":[{"text":"Verifiable Delay Functions (VDFs) introduced by Boneh et al. (CRYPTO'18) are functions that require a prescribed number of sequential steps T to evaluate, yet their output can be verified in time much faster than T. Since their introduction, VDFs have gained a lot of attention due to their applications in blockchain protocols, randomness beacons, timestamping and deniability. This thesis explores the theory and applications of VDFs, focusing on enhancing their soundness, efficiency and practicality.\r\n\r\nThe only practical VDFs known to date are based on repeated squaring in hidden order groups. Consider the function VDF(x,T)=x^(2^T).\r\nThe iterated squaring assumption states that, for a random group element x, the result of VDF cannot be computed significantly faster than performing T sequential squarings if the group order is unknown. To make the result verifiable a prover can compute a proof of exponentiation (PoE) \\pi. Given \\pi, the output of VDF can be verified in time much less than T.\r\n\r\nWe first present new constructions of statistically sound proofs of exponentiation, which are an important building block in the construction of SNARKs (Succinct Non-Interactive Argument of Knowledge). Statistical soundness means that the proofs remain secure against computationally unbounded adversaries, in particular, it remains secure even when the group order is known. We thereby address limitations in previous PoE protocols which either required (non-standard) hardness assumptions or a lot of parallel repetitions. Our construction significantly reduces the proof size of statistically sound PoEs that allow for a structured exponent, which leads to better efficiency of SNARKs and other applications.\r\n\r\nSecondly, we introduce improved batching techniques for PoEs, which allow multiple proofs to be aggregated and verified with minimal overhead. These protocols optimize communication and computation complexity in large-scale blockchain environments and enable scalable remote benchmarking of parallel computation resources.\r\n\r\nWe then construct VDFs with enhanced properties such as zero-knowledge and watermarkability. It was shown by Arun, Bonneau and Clark (ASIACRYPT'22) that these features enable new cryptographic primitives called short-lived proofs and signatures. The validity of such proofs and signatures expires after a predefined amount of time T, i.e., they are deniable after time T. Our constructions improve upon the constructions by Arun, Bonneau and Clark in several dimensions (faster forging times, arguably weaker assumptions).\r\n\r\nFinally, we apply PoEs in the realm of primality testing, providing cryptographically sound proofs of non-primality for large Proth numbers. This work gives a surprising application of VDFs in the area of computational number theory.\r\n\r\nTogether, our contributions advance both the theoretical foundations and the real-world usability of VDFs in general and in particular of PoEs, making them more adaptable and secure for current and emerging cryptographic applications.","lang":"eng"}],"type":"dissertation","publication_identifier":{"issn":["2663-337X"]},"date_updated":"2026-07-06T13:15:27Z","year":"2025","title":"Theory and applications of verifiable delay functions","related_material":{"record":[{"id":"13143","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"12176"},{"id":"20556","relation":"earlier_version","status":"public"},{"id":"19778","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"20701"}]},"corr_author":"1","file_date_updated":"2026-01-02T10:39:26Z","has_accepted_license":"1","date_published":"2025-12-31T00:00:00Z","language":[{"iso":"eng"}],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","month":"12","doi":"10.15479/AT-ISTA-20920","degree_awarded":"PhD","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","tmp":{"image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"date_created":"2026-01-02T10:46:47Z","day":"31","publication_status":"published","department":[{"_id":"GradSch"},{"_id":"KrPi"}],"page":"116","publisher":"Institute of Science and Technology Austria","file":[{"creator":"choffman","file_id":"20921","relation":"source_file","content_type":"application/x-zip-compressed","date_updated":"2026-01-02T10:39:16Z","access_level":"closed","file_size":8355494,"date_created":"2026-01-02T10:39:16Z","checksum":"8a099fbf54963bd0be38f7ce73658682","file_name":"2025_Hoffmann_Charlotte_Source.zip"},{"file_size":2258804,"date_created":"2026-01-02T10:39:26Z","checksum":"9521c07bfb2bb5b14a49c09fcfc96474","file_name":"2025_Hoffmann_Charlotte_Thesis.pdf","success":1,"creator":"choffman","file_id":"20922","relation":"main_file","date_updated":"2026-01-02T10:39:26Z","content_type":"application/pdf","access_level":"open_access"}],"oa":1,"supervisor":[{"last_name":"Pietrzak","first_name":"Krzysztof Z","orcid":"0000-0002-9139-1654","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","full_name":"Pietrzak, Krzysztof Z"}],"OA_place":"publisher","alternative_title":["ISTA Thesis"],"status":"public","ddc":["004"],"article_processing_charge":"No","_id":"20920"},{"publication_status":"published","date_created":"2025-10-27T14:16:56Z","day":"31","tmp":{"image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","degree_awarded":"PhD","_id":"20556","article_processing_charge":"No","ddc":["004"],"status":"public","alternative_title":["ISTA Thesis"],"OA_place":"publisher","supervisor":[{"first_name":"Krzysztof Z","orcid":"0000-0002-9139-1654","last_name":"Pietrzak","full_name":"Pietrzak, Krzysztof Z","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87"}],"file":[{"checksum":"1fffa4e2c33dd0b9f883d615504a2858","date_created":"2025-10-28T14:33:03Z","file_size":2259304,"file_name":"2025_Hoffmann_Charlotte_Thesis.pdf","date_updated":"2026-01-08T14:11:39Z","content_type":"application/pdf","access_level":"closed","relation":"main_file","file_id":"20573","creator":"choffman"},{"file_name":"2025_Hoffmann_Charlotte_Source.zip","file_size":9987633,"date_created":"2025-10-28T14:35:06Z","checksum":"076ea98a1f0a86c3bbc990b6b9460dc2","access_level":"closed","content_type":"application/x-zip-compressed","date_updated":"2025-11-11T09:34:54Z","creator":"choffman","file_id":"20574","relation":"source_file"}],"publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"KrPi"}],"page":"116","related_material":{"record":[{"id":"13143","relation":"part_of_dissertation","status":"public"},{"id":"12176","relation":"part_of_dissertation","status":"public"},{"id":"20920","status":"public","relation":"later_version"},{"relation":"part_of_dissertation","status":"public","id":"19778"},{"status":"public","relation":"part_of_dissertation","id":"20701"}]},"title":"Theory and applications of verifiable delay functions","year":"2025","date_updated":"2026-07-06T13:15:27Z","publication_identifier":{"issn":["2663-337X"]},"type":"dissertation","abstract":[{"lang":"eng","text":"Verifiable Delay Functions (VDFs) introduced by Boneh et al. (CRYPTO'18) are functions that require a prescribed number of sequential steps T to evaluate, yet their output can be verified in time much faster than T. Since their introduction, VDFs have gained a lot of attention due to their applications in blockchain protocols, randomness beacons, timestamping and deniability. This thesis explores the theory and applications of VDFs, focusing on enhancing their soundness, efficiency and practicality.\r\n\r\nThe only practical VDFs known to date are based on repeated squaring in hidden order groups. Consider the function VDF(x,T)=x^(2^T).\r\nThe iterated squaring assumption states that, for a random group element x, the result of VDF cannot be computed significantly faster than performing T sequential squarings if the group order is unknown. To make the result verifiable a prover can compute a proof of exponentiation (PoE) \\pi. Given \\pi, the output of VDF can be verified in time much less than T.\r\n\r\nWe first present new constructions of statistically sound proofs of exponentiation, which are an important building block in the construction of SNARKs (Succinct Non-Interactive Argument of Knowledge). Statistical soundness means that the proofs remain secure against computationally unbounded adversaries, in particular, it remains secure even when the group order is known. We thereby address limitations in previous PoE protocols which either required (non-standard) hardness assumptions or a lot of parallel repetitions. Our construction significantly reduces the proof size of statistically sound PoEs that allow for a structured exponent, which leads to better efficiency of SNARKs and other applications.\r\n\r\nSecondly, we introduce improved batching techniques for PoEs, which allow multiple proofs to be aggregated and verified with minimal overhead. These protocols optimize communication and computation complexity in large-scale blockchain environments and enable scalable remote benchmarking of parallel computation resources.\r\n\r\nWe then construct VDFs with enhanced properties such as zero-knowledge and watermarkability. It was shown by Arun, Bonneau and Clark (ASIACRYPT'22) that these features enable new cryptographic primitives called short-lived proofs and signatures. The validity of such proofs and signatures expires after a predefined amount of time T, i.e., they are deniable after time T. Our constructions improve upon the constructions by Arun, Bonneau and Clark in several dimensions (faster forging times, arguably weaker assumptions).\r\n\r\nFinally, we apply PoEs in the realm of primality testing, providing cryptographically sound proofs of non-primality for large Proth numbers. This work gives a surprising application of VDFs in the area of computational number theory.\r\n\r\nTogether, our contributions advance both the theoretical foundations and the real-world usability of VDFs in general and in particular of PoEs, making them more adaptable and secure for current and emerging cryptographic applications."}],"citation":{"mla":"Hoffmann, Charlotte. <i>Theory and Applications of Verifiable Delay Functions</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20556\">10.15479/AT-ISTA-20556</a>.","ieee":"C. Hoffmann, “Theory and applications of verifiable delay functions,” Institute of Science and Technology Austria, 2025.","chicago":"Hoffmann, Charlotte. “Theory and Applications of Verifiable Delay Functions.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20556\">https://doi.org/10.15479/AT-ISTA-20556</a>.","ista":"Hoffmann C. 2025. Theory and applications of verifiable delay functions. Institute of Science and Technology Austria.","short":"C. Hoffmann, Theory and Applications of Verifiable Delay Functions, Institute of Science and Technology Austria, 2025.","apa":"Hoffmann, C. (2025). <i>Theory and applications of verifiable delay functions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20556\">https://doi.org/10.15479/AT-ISTA-20556</a>","ama":"Hoffmann C. Theory and applications of verifiable delay functions. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20556\">10.15479/AT-ISTA-20556</a>"},"oa_version":"Published Version","author":[{"last_name":"Hoffmann","first_name":"Charlotte","orcid":"0000-0003-2027-5549","id":"0f78d746-dc7d-11ea-9b2f-83f92091afe7","full_name":"Hoffmann, Charlotte"}],"month":"10","doi":"10.15479/AT-ISTA-20556","language":[{"iso":"eng"}],"date_published":"2025-10-31T00:00:00Z","file_date_updated":"2026-01-08T14:11:39Z","has_accepted_license":"1","corr_author":"1"},{"date_updated":"2026-07-06T13:37:21Z","arxiv":1,"type":"journal_article","publication_identifier":{"eissn":["1945-743X"],"issn":["0022-040X"]},"title":"A new varifold solution concept for mean curvature flow: Convergence of  the Allen-Cahn equation and weak-strong uniqueness","year":"2025","oa_version":"Preprint","author":[{"full_name":"Hensel, Sebastian","id":"4D23B7DA-F248-11E8-B48F-1D18A9856A87","first_name":"Sebastian","orcid":"0000-0001-7252-8072","last_name":"Hensel"},{"full_name":"Laux, Tim","first_name":"Tim","last_name":"Laux"}],"citation":{"ama":"Hensel S, Laux T. A new varifold solution concept for mean curvature flow: Convergence of  the Allen-Cahn equation and weak-strong uniqueness. <i>Journal of Differential Geometry</i>. 2025;130:209-268. doi:<a href=\"https://doi.org/10.4310/jdg/1747065796\">10.4310/jdg/1747065796</a>","apa":"Hensel, S., &#38; Laux, T. (2025). A new varifold solution concept for mean curvature flow: Convergence of  the Allen-Cahn equation and weak-strong uniqueness. <i>Journal of Differential Geometry</i>. International Press of Boston. <a href=\"https://doi.org/10.4310/jdg/1747065796\">https://doi.org/10.4310/jdg/1747065796</a>","short":"S. Hensel, T. Laux, Journal of Differential Geometry 130 (2025) 209–268.","mla":"Hensel, Sebastian, and Tim Laux. “A New Varifold Solution Concept for Mean Curvature Flow: Convergence of  the Allen-Cahn Equation and Weak-Strong Uniqueness.” <i>Journal of Differential Geometry</i>, vol. 130, International Press of Boston, 2025, pp. 209–68, doi:<a href=\"https://doi.org/10.4310/jdg/1747065796\">10.4310/jdg/1747065796</a>.","ieee":"S. Hensel and T. Laux, “A new varifold solution concept for mean curvature flow: Convergence of  the Allen-Cahn equation and weak-strong uniqueness,” <i>Journal of Differential Geometry</i>, vol. 130. International Press of Boston, pp. 209–268, 2025.","ista":"Hensel S, Laux T. 2025. A new varifold solution concept for mean curvature flow: Convergence of  the Allen-Cahn equation and weak-strong uniqueness. Journal of Differential Geometry. 130, 209–268.","chicago":"Hensel, Sebastian, and Tim Laux. “A New Varifold Solution Concept for Mean Curvature Flow: Convergence of  the Allen-Cahn Equation and Weak-Strong Uniqueness.” <i>Journal of Differential Geometry</i>. International Press of Boston, 2025. <a href=\"https://doi.org/10.4310/jdg/1747065796\">https://doi.org/10.4310/jdg/1747065796</a>."},"abstract":[{"text":"We propose a new weak solution concept for (two-phase) mean curvature flow which enjoys both (unconditional) existence and (weak-strong) uniqueness properties. These solutions are evolving varifolds, just as in Brakke's formulation, but are coupled to the phase volumes by a simple transport equation. First, we show that, in the exact same setup as in Ilmanen's proof [J. Differential Geom. 38, 417-461, (1993)], any limit point of solutions to the Allen-Cahn equation is a varifold solution in our sense. Second, we prove that any calibrated flow in the sense of Fischer et al. [arXiv:2003.05478] - and hence any classical solution to mean curvature flow-is unique in the class of our new varifold solutions. This is in sharp contrast to the case of Brakke flows, which a priori may disappear at any given time and are therefore fatally non-unique. Finally, we propose an extension of the solution concept to the multi-phase case which is at least guaranteed to satisfy a weak-strong uniqueness principle.","lang":"eng"}],"scopus_import":"1","month":"05","doi":"10.4310/jdg/1747065796","ec_funded":1,"volume":130,"date_published":"2025-05-01T00:00:00Z","corr_author":"1","project":[{"call_identifier":"H2020","_id":"0aa76401-070f-11eb-9043-b5bb049fa26d","grant_number":"948819","name":"Bridging Scales in Random Materials"}],"language":[{"iso":"eng"}],"article_type":"original","intvolume":"       130","publication_status":"published","keyword":["Mean curvature flow","gradient flows","varifolds","weak solutions","weak-strong uniqueness","calibrated geometry","gradient-flow calibrations"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2109.04233"}],"day":"01","date_created":"2021-09-13T12:17:10Z","external_id":{"arxiv":["2109.04233"]},"quality_controlled":"1","das_tickbox":"1","acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 948819), and from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2047/1 – 390685813. The content of this paper was developed and parts of it were written during a visit of the first author to the Hausdorff Center of Mathematics (HCM), University of Bonn. The hospitality and the support of HCM are gratefully acknowledged.","_id":"10011","OA_type":"green","article_processing_charge":"No","oa":1,"department":[{"_id":"JuFi"}],"page":"209-268","publisher":"International Press of Boston","status":"public","publication":"Journal of Differential Geometry","OA_place":"repository"},{"language":[{"iso":"eng"}],"has_accepted_license":"1","project":[{"name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","call_identifier":"H2020"}],"file_date_updated":"2025-11-24T07:44:08Z","corr_author":"1","cryptoeprintid":1,"date_published":"2025-01-01T00:00:00Z","ec_funded":1,"month":"01","scopus_import":"1","abstract":[{"lang":"eng","text":"The Message Layer Security (MLS) protocol has recently been standardized by the IETF. MLS is a scalable secure group messaging protocol expected to run more efficiently compared to the Signal protocol at scale, while offering a similar level of strong security. Even though MLS has undergone extensive examination by researchers, the majority of the works have focused on confidentiality.\r\n\r\nIn this work, we focus on the authenticity of the application messages exchanged in MLS. Currently, MLS authenticates every application message with an EdDSA signature and while manageable, the overhead is greatly amplified in the post-quantum setting as the NIST-recommended Dilithium signature results in a 40x increase in size. We view this as an invitation to explore new authentication modes that can be used instead. We start by taking a systematic view on how application messages are authenticated in MLS and categorize authenticity into four different security notions. We then propose several authentication modes, offering a range of different efficiency and security profiles. For instance, in one of our modes, COSMOS++, we replace signatures with one-time tokens and a MAC tag, offering roughly a 75x savings in the post-quantum communication overhead. While this comes at the cost of weakening security compared to the authentication mode used by MLS, the lower communication overhead seems to make it a worthwhile trade-off with security."}],"citation":{"mla":"Hashimoto, Keitaro, et al. “Exploring How to Authenticate Application Messages in MLS: More Efficient, Post-Quantum, and Anonymous Blocklistable.” <i>34th Usenix Security Symposium</i>, Usenix Association, 2025, pp. 6699–716.","ieee":"K. Hashimoto, S. Katsumata, and G. Pascual Perez, “Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable,” in <i>34th Usenix Security Symposium</i>, Seattle, WA, USA, 2025, pp. 6699–6716.","chicago":"Hashimoto, Keitaro, Shuichi Katsumata, and Guillermo Pascual Perez. “Exploring How to Authenticate Application Messages in MLS: More Efficient, Post-Quantum, and Anonymous Blocklistable.” In <i>34th Usenix Security Symposium</i>, 6699–6716. Usenix Association, 2025.","ista":"Hashimoto K, Katsumata S, Pascual Perez G. 2025. Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable. 34th Usenix Security Symposium. USENIX: Security Symposium, 6699–6716.","short":"K. Hashimoto, S. Katsumata, G. Pascual Perez, in:, 34th Usenix Security Symposium, Usenix Association, 2025, pp. 6699–6716.","apa":"Hashimoto, K., Katsumata, S., &#38; Pascual Perez, G. (2025). Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable. In <i>34th Usenix Security Symposium</i> (pp. 6699–6716). Seattle, WA, USA: Usenix Association.","ama":"Hashimoto K, Katsumata S, Pascual Perez G. Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable. In: <i>34th Usenix Security Symposium</i>. Usenix Association; 2025:6699-6716."},"author":[{"full_name":"Hashimoto, Keitaro","first_name":"Keitaro","last_name":"Hashimoto"},{"full_name":"Katsumata, Shuichi","last_name":"Katsumata","first_name":"Shuichi"},{"orcid":"0000-0001-8630-415X","first_name":"Guillermo","last_name":"Pascual Perez","full_name":"Pascual Perez, Guillermo","id":"2D7ABD02-F248-11E8-B48F-1D18A9856A87"}],"conference":{"name":"USENIX: Security Symposium","end_date":"2025-08-15","start_date":"2025-08-13","location":"Seattle, WA, USA"},"oa_version":"Published Version","year":"2025","title":"Exploring how to authenticate application messages in MLS: More efficient, post-quantum, and anonymous blocklistable","publication_identifier":{"isbn":["9781939133526"]},"type":"conference","date_updated":"2026-07-07T06:02:03Z","OA_place":"publisher","publication":"34th Usenix Security Symposium","status":"public","publisher":"Usenix Association","page":"6699-6716","file":[{"success":1,"checksum":"fcfe8851aeb751af98c0b1335a0ef149","file_size":710733,"date_created":"2025-11-24T07:44:08Z","file_name":"2025_Usenix_Hashimoto.pdf","date_updated":"2025-11-24T07:44:08Z","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_id":"20671","creator":"dernst"}],"oa":1,"_id":"20668","OA_type":"diamond","article_processing_charge":"No","acknowledgement":"This research was partially supported by JST CREST JPMJCR22M1, Japan and funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No.665385.","das_tickbox":"1","ddc":["000"],"external_id":{"cryptoeprintid":["2025/426"]},"quality_controlled":"1","date_created":"2025-11-23T23:01:40Z","day":"01","main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2025/426"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published"}]