[{"intvolume":" 12","ddc":["540"],"date_updated":"2026-05-12T06:50:12Z","OA_type":"closed access","type":"journal_article","scopus_import":"1","date_created":"2026-05-06T10:43:33Z","publication":"Journal of Materials Chemistry C","oa_version":"None","status":"public","abstract":[{"lang":"eng","text":"Light-responsive liquid crystal elastomer networks (LCNs) have received significant interest due to their potential application in soft robotics and shape-morphing devices. Here, we present a systematic examination of light-responsive LCNs prepared using a catalyst-free Diels–Alder cycloaddition and a new azobenzene functionalized monomer for main-chain incorporation. The networks have robust mechanical stiffness that can be reversibly modulated by 1 GPa by turning the UV light on and off. This study highlights the contribution of photothermal softening to reversibly control rheological properties of the newly developed LCNs and demonstrates the ability to tune the modulus on demand. We believe this work will guide future developments of light-responsive LCNs based on the newly developed Diels–Alder cycloaddition."}],"language":[{"iso":"eng"}],"article_type":"original","citation":{"chicago":"Park, Minwook, Jesus Guillen Campos, Friedrich J Stricker, and Javier Read de Alaniz. “Photo-Responsive Diels-Alder Based Azobenzene-Functionalized Main-Chain Liquid Crystal Networks.” Journal of Materials Chemistry C. Royal Society of Chemistry, 2024. https://doi.org/10.1039/d4tc01281j.","short":"M. Park, J. Guillen Campos, F.J. Stricker, J. Read de Alaniz, Journal of Materials Chemistry C 12 (2024) 11976–11981.","mla":"Park, Minwook, et al. “Photo-Responsive Diels-Alder Based Azobenzene-Functionalized Main-Chain Liquid Crystal Networks.” Journal of Materials Chemistry C, vol. 12, no. 31, Royal Society of Chemistry, 2024, pp. 11976–81, doi:10.1039/d4tc01281j.","ama":"Park M, Guillen Campos J, Stricker FJ, Read de Alaniz J. Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks. Journal of Materials Chemistry C. 2024;12(31):11976-11981. doi:10.1039/d4tc01281j","ista":"Park M, Guillen Campos J, Stricker FJ, Read de Alaniz J. 2024. Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks. Journal of Materials Chemistry C. 12(31), 11976–11981.","ieee":"M. Park, J. Guillen Campos, F. J. Stricker, and J. Read de Alaniz, “Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks,” Journal of Materials Chemistry C, vol. 12, no. 31. Royal Society of Chemistry, pp. 11976–11981, 2024.","apa":"Park, M., Guillen Campos, J., Stricker, F. J., & Read de Alaniz, J. (2024). Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks. Journal of Materials Chemistry C. Royal Society of Chemistry. https://doi.org/10.1039/d4tc01281j"},"year":"2024","publication_status":"published","volume":12,"issue":"31","month":"07","author":[{"last_name":"Park","first_name":"Minwook","full_name":"Park, Minwook"},{"last_name":"Guillen Campos","first_name":"Jesus","full_name":"Guillen Campos, Jesus"},{"last_name":"Stricker","first_name":"Friedrich J","id":"7aca2cfc-46cf-11f0-abd3-8c96b5186745","full_name":"Stricker, Friedrich J"},{"full_name":"Read de Alaniz, Javier","last_name":"Read de Alaniz","first_name":"Javier"}],"page":"11976-11981","extern":"1","doi":"10.1039/d4tc01281j","publisher":"Royal Society of Chemistry","_id":"21806","quality_controlled":"1","date_published":"2024-07-10T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks","day":"10","article_processing_charge":"No","publication_identifier":{"eissn":["2050-7534"],"issnl":["2050-7526"]}},{"article_processing_charge":"No","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"day":"06","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Programming liquid crystal elastomers for multistep ambidirectional deformability","quality_controlled":"1","_id":"21817","date_published":"2024-12-06T00:00:00Z","doi":"10.1126/science.adq6434","publisher":"American Association for the Advancement of Science","extern":"1","pmid":1,"page":"1161-1168","author":[{"first_name":"Yuxing","last_name":"Yao","full_name":"Yao, Yuxing"},{"full_name":"Wilborn, Atalaya Milan","last_name":"Wilborn","first_name":"Atalaya Milan"},{"full_name":"Lemaire, Baptiste","last_name":"Lemaire","first_name":"Baptiste"},{"first_name":"Foteini","last_name":"Trigka","full_name":"Trigka, Foteini"},{"full_name":"Stricker, Friedrich J","id":"7aca2cfc-46cf-11f0-abd3-8c96b5186745","last_name":"Stricker","first_name":"Friedrich J"},{"last_name":"Weible","first_name":"Alan H.","full_name":"Weible, Alan H."},{"first_name":"Shucong","last_name":"Li","full_name":"Li, Shucong"},{"full_name":"Bennett, Robert K. A.","first_name":"Robert K. A.","last_name":"Bennett"},{"last_name":"Cheung","first_name":"Tung Chun","full_name":"Cheung, Tung Chun"},{"first_name":"Alison","last_name":"Grinthal","full_name":"Grinthal, Alison"},{"first_name":"Mikhail","last_name":"Zhernenkov","full_name":"Zhernenkov, Mikhail"},{"full_name":"Freychet, Guillaume","first_name":"Guillaume","last_name":"Freychet"},{"first_name":"Patryk","last_name":"Wąsik","full_name":"Wąsik, Patryk"},{"first_name":"Boris","last_name":"Kozinsky","full_name":"Kozinsky, Boris"},{"full_name":"Lerch, Michael M.","first_name":"Michael M.","last_name":"Lerch"},{"full_name":"Wang, Xiaoguang","first_name":"Xiaoguang","last_name":"Wang"},{"last_name":"Aizenberg","first_name":"Joanna","full_name":"Aizenberg, Joanna"}],"issue":"6726","volume":386,"month":"12","year":"2024","publication_status":"published","article_type":"original","citation":{"chicago":"Yao, Yuxing, Atalaya Milan Wilborn, Baptiste Lemaire, Foteini Trigka, Friedrich J Stricker, Alan H. Weible, Shucong Li, et al. “Programming Liquid Crystal Elastomers for Multistep Ambidirectional Deformability.” Science. American Association for the Advancement of Science, 2024. https://doi.org/10.1126/science.adq6434.","ama":"Yao Y, Wilborn AM, Lemaire B, et al. Programming liquid crystal elastomers for multistep ambidirectional deformability. Science. 2024;386(6726):1161-1168. doi:10.1126/science.adq6434","ista":"Yao Y, Wilborn AM, Lemaire B, Trigka F, Stricker FJ, Weible AH, Li S, Bennett RKA, Cheung TC, Grinthal A, Zhernenkov M, Freychet G, Wąsik P, Kozinsky B, Lerch MM, Wang X, Aizenberg J. 2024. Programming liquid crystal elastomers for multistep ambidirectional deformability. Science. 386(6726), 1161–1168.","ieee":"Y. Yao et al., “Programming liquid crystal elastomers for multistep ambidirectional deformability,” Science, vol. 386, no. 6726. American Association for the Advancement of Science, pp. 1161–1168, 2024.","apa":"Yao, Y., Wilborn, A. M., Lemaire, B., Trigka, F., Stricker, F. J., Weible, A. H., … Aizenberg, J. (2024). Programming liquid crystal elastomers for multistep ambidirectional deformability. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.adq6434","short":"Y. Yao, A.M. Wilborn, B. Lemaire, F. Trigka, F.J. Stricker, A.H. Weible, S. Li, R.K.A. Bennett, T.C. Cheung, A. Grinthal, M. Zhernenkov, G. Freychet, P. Wąsik, B. Kozinsky, M.M. Lerch, X. Wang, J. Aizenberg, Science 386 (2024) 1161–1168.","mla":"Yao, Yuxing, et al. “Programming Liquid Crystal Elastomers for Multistep Ambidirectional Deformability.” Science, vol. 386, no. 6726, American Association for the Advancement of Science, 2024, pp. 1161–68, doi:10.1126/science.adq6434."},"language":[{"iso":"eng"}],"oa_version":"None","scopus_import":"1","publication":"Science","date_created":"2026-05-06T10:54:51Z","type":"journal_article","abstract":[{"lang":"eng","text":"Ambidirectionality, which is the ability of structural elements to move beyond a reference state in two opposite directions, is common in nature. However, conventional soft materials are typically limited to a single, unidirectional deformation unless complex hybrid constructs are used. We exploited the combination of mesogen self-assembly, polymer chain elasticity, and polymerization-induced stress to design liquid crystalline elastomers that exhibit two mesophases: chevron smectic C (cSmC) and smectic A (SmA). Inducing the cSmC-SmA–isotropic phase transition led to an unusual inversion of the strain field in the microstructure, resulting in opposite deformation modes (e.g., consecutive shrinkage or expansion and right-handed or left-handed twisting and tilting in opposite directions) and high-frequency nonmonotonic oscillations. This ambidirectional movement is scalable and can be used to generate Gaussian transformations at the macroscale."}],"status":"public","external_id":{"pmid":["39636998"]},"OA_type":"closed access","intvolume":" 386","date_updated":"2026-05-12T09:48:12Z","ddc":["540"]},{"article_number":"107604","_id":"21913","quality_controlled":"1","date_published":"2024-09-01T00:00:00Z","extern":"1","publisher":"Elsevier","acknowledgement":"We would like to acknowledge Elliot Dean and Christina Freeman for technical assistance with recombinant protein expression in insect cells and members of the Marmorstein laboratory for many discussions related to this work. Schematic Figures were created with BioRender.com.","doi":"10.1016/j.jbc.2024.107604","PlanS_conform":"1","publication_identifier":{"eissn":["1083-351X"],"issn":["0021-9258"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"Yes","oa":1,"title":"HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"01","abstract":[{"text":"The HIRA histone chaperone complex is comprised of four protein subunits: HIRA, UBN1, CABIN1, and transiently associated ASF1a. All four subunits have been demonstrated to play a role in the deposition of the histone variant H3.3 onto areas of actively transcribed euchromatin in cells. The mechanism by which these subunits function together to drive histone deposition has remained poorly understood. Here we present biochemical and biophysical data supporting a model whereby ASF1a delivers histone H3.3/H4 dimers to the HIRA complex, H3.3/H4 tetramerization drives the association of two HIRA/UBN1 complexes, and the affinity of the histones for DNA drives release of ASF1a and subsequent histone deposition. These findings have implications for understanding how other histone chaperone complexes may mediate histone deposition.","lang":"eng"}],"has_accepted_license":"1","status":"public","external_id":{"pmid":["39059488"]},"publication":"Journal of Biological Chemistry","oa_version":"Published Version","date_created":"2026-05-24T08:25:45Z","type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1016/j.jbc.2024.107604","open_access":"1"}],"citation":{"chicago":"Vogt, Austin, Mary Szurgot, Lauren Gardner, David C. Schultz, and Ronen Marmorstein. “HIRA Complex Deposition of Histone H3.3 Is Driven by Histone Tetramerization and Histone-DNA Binding.” Journal of Biological Chemistry. Elsevier, 2024. https://doi.org/10.1016/j.jbc.2024.107604.","mla":"Vogt, Austin, et al. “HIRA Complex Deposition of Histone H3.3 Is Driven by Histone Tetramerization and Histone-DNA Binding.” Journal of Biological Chemistry, vol. 300, no. 9, 107604, Elsevier, 2024, doi:10.1016/j.jbc.2024.107604.","short":"A. Vogt, M. Szurgot, L. Gardner, D.C. Schultz, R. Marmorstein, Journal of Biological Chemistry 300 (2024).","apa":"Vogt, A., Szurgot, M., Gardner, L., Schultz, D. C., & Marmorstein, R. (2024). HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding. Journal of Biological Chemistry. Elsevier. https://doi.org/10.1016/j.jbc.2024.107604","ista":"Vogt A, Szurgot M, Gardner L, Schultz DC, Marmorstein R. 2024. HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding. Journal of Biological Chemistry. 300(9), 107604.","ieee":"A. Vogt, M. Szurgot, L. Gardner, D. C. Schultz, and R. Marmorstein, “HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding,” Journal of Biological Chemistry, vol. 300, no. 9. Elsevier, 2024.","ama":"Vogt A, Szurgot M, Gardner L, Schultz DC, Marmorstein R. HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding. Journal of Biological Chemistry. 2024;300(9). doi:10.1016/j.jbc.2024.107604"},"article_type":"original","DOAJ_listed":"1","language":[{"iso":"eng"}],"date_updated":"2026-06-02T14:52:50Z","ddc":["572"],"OA_place":"publisher","intvolume":" 300","OA_type":"gold","author":[{"last_name":"Vogt","first_name":"Austin","full_name":"Vogt, Austin"},{"last_name":"Szurgot","first_name":"Mary","full_name":"Szurgot, Mary"},{"full_name":"Gardner, Lauren","id":"f9dedd98-6d15-11f0-88a5-a7b4143fdec5","last_name":"Gardner","orcid":"0009-0000-5733-1546","first_name":"Lauren"},{"last_name":"Schultz","first_name":"David C.","full_name":"Schultz, David C."},{"full_name":"Marmorstein, Ronen","first_name":"Ronen","last_name":"Marmorstein"}],"pmid":1,"publication_status":"published","year":"2024","month":"09","issue":"9","volume":300},{"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"21918"}]},"day":"18","department":[{"_id":"NiBa"},{"_id":"JaMa"}],"month":"10","year":"2024","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publication_status":"draft","oa":1,"title":"Genealogies under purifying selection","article_processing_charge":"No","tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"author":[{"id":"4E6DC800-AE37-11E9-AC72-31CAE5697425","full_name":"Khudiakova, Kseniia","first_name":"Kseniia","orcid":"0000-0002-6246-1465","last_name":"Khudiakova"},{"full_name":"Boenkost, Florin","last_name":"Boenkost","first_name":"Florin"},{"full_name":"Tourniaire, Julie N","id":"5dc06dd8-8e51-11ec-9170-8d9c450cc216","last_name":"Tourniaire","first_name":"Julie N"}],"OA_type":"green","acknowledgement":"This work was supported by the Austrian Academy of Science, DOC fellowship No 26293 (K.K.) and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034413 (J.T.). Simulations were performed on the ISTA High-performance Computing Cluster.","project":[{"grant_number":"26293","name":"The impact of deleterious mutations on small populations","_id":"34d33d68-11ca-11ed-8bc3-ec13763c0ca8"},{"grant_number":"101034413","call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program"}],"doi":"10.1101/2024.10.15.618444","date_updated":"2026-06-12T12:43:34Z","_id":"21967","date_published":"2024-10-18T00:00:00Z","ec_funded":1,"citation":{"ista":"Khudiakova K, Boenkost F, Tourniaire JN. Genealogies under purifying selection. bioRxiv, 10.1101/2024.10.15.618444.","ieee":"K. Khudiakova, F. Boenkost, and J. N. Tourniaire, “Genealogies under purifying selection,” bioRxiv. .","ama":"Khudiakova K, Boenkost F, Tourniaire JN. Genealogies under purifying selection. bioRxiv. doi:10.1101/2024.10.15.618444","apa":"Khudiakova, K., Boenkost, F., & Tourniaire, J. N. (n.d.). Genealogies under purifying selection. bioRxiv. https://doi.org/10.1101/2024.10.15.618444","short":"K. Khudiakova, F. Boenkost, J.N. Tourniaire, BioRxiv (n.d.).","mla":"Khudiakova, Kseniia, et al. “Genealogies under Purifying Selection.” BioRxiv, doi:10.1101/2024.10.15.618444.","chicago":"Khudiakova, Kseniia, Florin Boenkost, and Julie N Tourniaire. “Genealogies under Purifying Selection.” BioRxiv, n.d. https://doi.org/10.1101/2024.10.15.618444."},"language":[{"iso":"eng"}],"date_created":"2026-06-09T12:14:08Z","publication":"bioRxiv","oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2024.10.15.618444"}],"corr_author":"1","type":"preprint","abstract":[{"text":"Selection against deleterious mutations, called purifying selection, plays a central role in evolution and acts in all populations. It is known that the genetic patterns observed in genomic regions undergoing purifying selection differ from those resulting from neutral evolution. However, a comprehensive understanding of the underlying mechanisms shaping those patterns is still lacking.\r\n\r\nIn the present work, we use simulations combined with a genealogical approach to identify the effect of purifying selection on the ancestry and thus on the genetic diversity. Our analysis relies on the postulate that the genealogy belongs to the universality class of Beta-coalescents. Under this assumption, we derive statistics measuring the distortion of the genealogy. This approach allows us to consider a wide range of regimes (i.e. arbitrary selection and mutation strengths) and uncover a rich phase diagram. We find that, for strong selection, the limiting genealogy is given by Kingman’s coalescent on a polynomial timescale. As selection gets weaker, Muller’s ratchet starts operating, setting off the emergence of multiple mergers in the genealogical structures. Our results show that while multiple-merger coalescents are often interpreted as the signature of selective sweeps in rapidly adapting populations, these structures can also appear in the context of Muller’s ratchet.","lang":"eng"}],"status":"public"},{"month":"09","related_material":{"record":[{"id":"6647","status":"public","relation":"earlier_version"}]},"volume":72,"publication_status":"published","year":"2024","page":"831-848","author":[{"last_name":"Fulek","first_name":"Radoslav","orcid":"0000-0001-8485-1774","id":"39F3FFE4-F248-11E8-B48F-1D18A9856A87","full_name":"Fulek, Radoslav"},{"last_name":"Gärtner","first_name":"Bernd","full_name":"Gärtner, Bernd"},{"full_name":"Kupavskii, Andrey","last_name":"Kupavskii","first_name":"Andrey"},{"full_name":"Valtr, Pavel","first_name":"Pavel","last_name":"Valtr"},{"id":"36690CA2-F248-11E8-B48F-1D18A9856A87","full_name":"Wagner, Uli","first_name":"Uli","orcid":"0000-0002-1494-0568","last_name":"Wagner"}],"project":[{"grant_number":"M02281","call_identifier":"FWF","_id":"261FA626-B435-11E9-9278-68D0E5697425","name":"Eliminating intersections in drawings of graphs"}],"OA_type":"green","date_updated":"2025-04-14T13:52:36Z","arxiv":1,"intvolume":" 72","OA_place":"repository","citation":{"apa":"Fulek, R., Gärtner, B., Kupavskii, A., Valtr, P., & Wagner, U. (2024). The crossing Tverberg theorem. Discrete and Computational Geometry. Springer Nature. https://doi.org/10.1007/s00454-023-00532-x","ama":"Fulek R, Gärtner B, Kupavskii A, Valtr P, Wagner U. The crossing Tverberg theorem. Discrete and Computational Geometry. 2024;72:831-848. doi:10.1007/s00454-023-00532-x","ista":"Fulek R, Gärtner B, Kupavskii A, Valtr P, Wagner U. 2024. The crossing Tverberg theorem. Discrete and Computational Geometry. 72, 831–848.","ieee":"R. Fulek, B. Gärtner, A. Kupavskii, P. Valtr, and U. Wagner, “The crossing Tverberg theorem,” Discrete and Computational Geometry, vol. 72. Springer Nature, pp. 831–848, 2024.","mla":"Fulek, Radoslav, et al. “The Crossing Tverberg Theorem.” Discrete and Computational Geometry, vol. 72, Springer Nature, 2024, pp. 831–48, doi:10.1007/s00454-023-00532-x.","short":"R. Fulek, B. Gärtner, A. Kupavskii, P. Valtr, U. Wagner, Discrete and Computational Geometry 72 (2024) 831–848.","chicago":"Fulek, Radoslav, Bernd Gärtner, Andrey Kupavskii, Pavel Valtr, and Uli Wagner. “The Crossing Tverberg Theorem.” Discrete and Computational Geometry. Springer Nature, 2024. https://doi.org/10.1007/s00454-023-00532-x."},"article_type":"original","language":[{"iso":"eng"}],"abstract":[{"text":"The Tverberg theorem is one of the cornerstones of discrete geometry. It states that, given a set X of at least (d+1)(r−1)+1 points in Rd, one can find a partition X=X1∪⋯∪Xr of X, such that the convex hulls of the Xi, i=1,…,r, all share a common point. In this paper, we prove a trengthening of this theorem that guarantees a partition which, in addition to the above, has the property that the boundaries of full-dimensional convex hulls have pairwise nonempty intersections. Possible generalizations and algorithmic aspects are also discussed. As a concrete application, we show that any n points in the plane in general position span ⌊n/3⌋ vertex-disjoint triangles that are pairwise crossing, meaning that their boundaries have pairwise nonempty intersections; this number is clearly best possible. A previous result of Álvarez-Rebollar et al. guarantees ⌊n/6⌋pairwise crossing triangles. Our result generalizes to a result about simplices in Rd, d≥2.","lang":"eng"}],"status":"public","external_id":{"arxiv":["1812.04911"],"isi":["001038546500001"]},"scopus_import":"1","oa_version":"Preprint","date_created":"2023-08-06T22:01:12Z","publication":"Discrete and Computational Geometry","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1812.04911"}],"type":"journal_article","department":[{"_id":"UlWa"}],"day":"01","oa":1,"title":"The crossing Tverberg theorem","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0179-5376"],"eissn":["1432-0444"]},"article_processing_charge":"No","publisher":"Springer Nature","isi":1,"acknowledgement":"Part of the research leading to this paper was done during the 16th Gremo Workshop on Open Problems (GWOP), Waltensburg, Switzerland, June 12–16, 2018. We thank Patrick Schnider for suggesting the problem, and Stefan Felsner, Malte Milatz, and Emo Welzl for fruitful discussions during the workshop. We also thank Stefan Felsner and Manfred Scheucher for finding, communicating the example from Sect. 3.3, and the kind permission to include their visualization of the point set. We thank Dömötör Pálvölgyi, the SoCG reviewers, and DCG reviewers for various helpful comments.\r\nR. Fulek gratefully acknowledges support from Austrian Science Fund (FWF), Project M2281-N35. A. Kupavskii was supported by the Advanced Postdoc.Mobility Grant no. P300P2_177839 of the Swiss National Science Foundation. Research by P. Valtr was supported by the Grant no. 18-19158 S of the Czech Science Foundation (GAČR).","doi":"10.1007/s00454-023-00532-x","quality_controlled":"1","_id":"13974","date_published":"2024-09-01T00:00:00Z"},{"day":"01","department":[{"_id":"LaEr"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"Spectrum of Lévy–Khintchine random laplacian matrices","article_processing_charge":"Yes (via OA deal)","publication_identifier":{"eissn":["1572-9230"],"issn":["0894-9840"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"isi":1,"file":[{"file_size":555070,"date_updated":"2024-07-22T09:41:21Z","file_id":"17300","file_name":"2024_JourTheorProbab_Campbell.pdf","checksum":"f7793d313104c70422140c5e6494c779","success":1,"access_level":"open_access","relation":"main_file","creator":"dernst","date_created":"2024-07-22T09:41:21Z","content_type":"application/pdf"}],"doi":"10.1007/s10959-023-01275-4","acknowledgement":"The first author thanks Yizhe Zhu for pointing out reference [30]. We thank David Renfrew for comments on an earlier draft. We thank the anonymous referee for a careful reading and helpful comments.\r\nOpen access funding provided by Institute of Science and Technology (IST Austria).","publisher":"Springer Nature","quality_controlled":"1","_id":"13975","date_published":"2024-03-01T00:00:00Z","volume":37,"month":"03","year":"2024","publication_status":"published","file_date_updated":"2024-07-22T09:41:21Z","page":"933-973","author":[{"full_name":"Campbell, Andrew J","id":"582b06a9-1f1c-11ee-b076-82ffce00dde4","last_name":"Campbell","first_name":"Andrew J"},{"first_name":"Sean","last_name":"O’Rourke","full_name":"O’Rourke, Sean"}],"intvolume":" 37","date_updated":"2024-07-22T09:41:42Z","ddc":["510"],"arxiv":1,"citation":{"apa":"Campbell, A. J., & O’Rourke, S. (2024). Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. Springer Nature. https://doi.org/10.1007/s10959-023-01275-4","ama":"Campbell AJ, O’Rourke S. Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. 2024;37:933-973. doi:10.1007/s10959-023-01275-4","ista":"Campbell AJ, O’Rourke S. 2024. Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. 37, 933–973.","ieee":"A. J. Campbell and S. O’Rourke, “Spectrum of Lévy–Khintchine random laplacian matrices,” Journal of Theoretical Probability, vol. 37. Springer Nature, pp. 933–973, 2024.","mla":"Campbell, Andrew J., and Sean O’Rourke. “Spectrum of Lévy–Khintchine Random Laplacian Matrices.” Journal of Theoretical Probability, vol. 37, Springer Nature, 2024, pp. 933–73, doi:10.1007/s10959-023-01275-4.","short":"A.J. Campbell, S. O’Rourke, Journal of Theoretical Probability 37 (2024) 933–973.","chicago":"Campbell, Andrew J, and Sean O’Rourke. “Spectrum of Lévy–Khintchine Random Laplacian Matrices.” Journal of Theoretical Probability. Springer Nature, 2024. https://doi.org/10.1007/s10959-023-01275-4."},"article_type":"original","language":[{"iso":"eng"}],"oa_version":"Published Version","publication":"Journal of Theoretical Probability","date_created":"2023-08-06T22:01:13Z","scopus_import":"1","corr_author":"1","type":"journal_article","abstract":[{"text":"We consider the spectrum of random Laplacian matrices of the form Ln=An−Dn where An\r\n is a real symmetric random matrix and Dn is a diagonal matrix whose entries are equal to the corresponding row sums of An. If An is a Wigner matrix with entries in the domain of attraction of a Gaussian distribution, the empirical spectral measure of Ln is known to converge to the free convolution of a semicircle distribution and a standard real Gaussian distribution. We consider real symmetric random matrices An with independent entries (up to symmetry) whose row sums converge to a purely non-Gaussian infinitely divisible distribution, which fall into the class of Lévy–Khintchine random matrices first introduced by Jung [Trans Am Math Soc, 370, (2018)]. Our main result shows that the empirical spectral measure of Ln converges almost surely to a deterministic limit. A key step in the proof is to use the purely non-Gaussian nature of the row sums to build a random operator to which Ln converges in an appropriate sense. This operator leads to a recursive distributional equation uniquely describing the Stieltjes transform of the limiting empirical spectral measure.","lang":"eng"}],"has_accepted_license":"1","status":"public","external_id":{"arxiv":["2210.07927"],"isi":["001038341000001"]}},{"citation":{"chicago":"Lao, Dong, Zhengyang Hu, Francesco Locatello, Yanchao Yang, and Stefano Soatto. “Divided Attention: Unsupervised Multi-Object Discovery with Contextually Separated Slots.” In 1st Conference on Parsimony and Learning, 2024.","ieee":"D. Lao, Z. Hu, F. Locatello, Y. Yang, and S. Soatto, “Divided attention: Unsupervised multi-object discovery with contextually separated slots,” in 1st Conference on Parsimony and Learning, Hong Kong, China, 2024.","ista":"Lao D, Hu Z, Locatello F, Yang Y, Soatto S. 2024. Divided attention: Unsupervised multi-object discovery with contextually separated slots. 1st Conference on Parsimony and Learning. CPAL: Conference on Parsimony and Learning.","ama":"Lao D, Hu Z, Locatello F, Yang Y, Soatto S. Divided attention: Unsupervised multi-object discovery with contextually separated slots. In: 1st Conference on Parsimony and Learning. ; 2024.","apa":"Lao, D., Hu, Z., Locatello, F., Yang, Y., & Soatto, S. (2024). Divided attention: Unsupervised multi-object discovery with contextually separated slots. In 1st Conference on Parsimony and Learning. Hong Kong, China.","short":"D. Lao, Z. Hu, F. Locatello, Y. Yang, S. Soatto, in:, 1st Conference on Parsimony and Learning, 2024.","mla":"Lao, Dong, et al. “Divided Attention: Unsupervised Multi-Object Discovery with Contextually Separated Slots.” 1st Conference on Parsimony and Learning, 2024."},"language":[{"iso":"eng"}],"date_published":"2024-01-03T00:00:00Z","_id":"14213","quality_controlled":"1","abstract":[{"text":"We introduce a method to segment the visual field into independently moving regions, trained with no ground truth or supervision. It consists of an adversarial conditional encoder-decoder architecture based on Slot Attention, modified to use the image as context to decode optical flow without attempting to reconstruct the image itself. In the resulting multi-modal representation, one modality (flow) feeds the encoder to produce separate latent codes (slots), whereas the other modality (image) conditions the decoder to generate the first (flow) from the slots. This design frees the representation from having to encode complex nuisance variability in the image due to, for instance, illumination and reflectance properties of the scene. Since customary autoencoding based on minimizing the reconstruction error does not preclude the entire flow from being encoded into a single slot, we modify the loss to an adversarial criterion based on Contextual Information Separation. The resulting min-max optimization fosters the separation of objects and their assignment to different attention slots, leading to Divided Attention, or DivA. DivA outperforms recent unsupervised multi-object motion segmentation methods while tripling run-time speed up to 104FPS and reducing the performance gap from supervised methods to 12% or less. DivA can handle different numbers of objects and different image sizes at training and test time, is invariant to permutation of object labels, and does not require explicit regularization.","lang":"eng"}],"external_id":{"arxiv":["2304.01430"]},"has_accepted_license":"1","status":"public","oa_version":"Published Version","publication":"1st Conference on Parsimony and Learning","date_created":"2023-08-22T14:19:59Z","type":"conference","file":[{"access_level":"open_access","relation":"main_file","creator":"dernst","content_type":"application/pdf","date_created":"2024-02-12T08:40:36Z","file_size":8038511,"date_updated":"2024-02-12T08:40:36Z","file_name":"2024_CPAL_Lao.pdf","file_id":"14978","success":1,"checksum":"8fad894c34f1b3d5a14fb8ffb12f7277"}],"date_updated":"2024-02-12T08:56:23Z","conference":{"name":"CPAL: Conference on Parsimony and Learning","end_date":"2024-01-03","location":"Hong Kong, China","start_date":"2024-01-03"},"arxiv":1,"ddc":["000"],"article_processing_charge":"No","author":[{"full_name":"Lao, Dong","last_name":"Lao","first_name":"Dong"},{"first_name":"Zhengyang","last_name":"Hu","full_name":"Hu, Zhengyang"},{"id":"26cfd52f-2483-11ee-8040-88983bcc06d4","full_name":"Locatello, Francesco","last_name":"Locatello","first_name":"Francesco","orcid":"0000-0002-4850-0683"},{"first_name":"Yanchao","last_name":"Yang","full_name":"Yang, Yanchao"},{"full_name":"Soatto, Stefano","first_name":"Stefano","last_name":"Soatto"}],"month":"01","department":[{"_id":"FrLo"}],"day":"03","oa":1,"publication_status":"published","file_date_updated":"2024-02-12T08:40:36Z","title":"Divided attention: Unsupervised multi-object discovery with contextually separated slots","year":"2024","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"author":[{"id":"19BDF720-25A0-11EA-AC6E-928F3DDC885E","full_name":"Tang, Han","first_name":"Han","orcid":"0000-0001-6152-6637","last_name":"Tang"},{"last_name":"Lu","first_name":"KJ","full_name":"Lu, KJ"},{"first_name":"Y","last_name":"Zhang","full_name":"Zhang, Y"},{"full_name":"Cheng, YL","first_name":"YL","last_name":"Cheng"},{"full_name":"Tu, SL","first_name":"SL","last_name":"Tu"},{"full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jiří"}],"pmid":1,"year":"2024","publication_status":"published","file_date_updated":"2024-01-30T12:59:57Z","volume":5,"issue":"1","month":"01","type":"journal_article","corr_author":"1","scopus_import":"1","oa_version":"Published Version","date_created":"2023-09-01T11:32:02Z","publication":"Plant Communications","has_accepted_license":"1","status":"public","external_id":{"pmid":["37528584"],"isi":["001158054500001"]},"abstract":[{"lang":"eng","text":"The phytohormone auxin and its directional transport through tissues play a fundamental role in development of higher plants. This polar auxin transport predominantly relies on PIN-FORMED (PIN) auxin exporters. Hence, PIN polarization is crucial for development, but its evolution during the rise of morphological complexity in land plants remains unclear. Here, we performed a cross-species investigation by observing the trafficking and localization of endogenous and exogenous PINs in two bryophytes, Physcomitrium patens and Marchantia polymorpha, and in the flowering plant Arabidopsis thaliana. We confirmed that the GFP fusion did not compromise the auxin export function of all examined PINs by using radioactive auxin export assay and by observing the phenotypic changes in transgenic bryophytes. Endogenous PINs polarize to filamentous apices, while exogenous Arabidopsis PINs distribute symmetrically on the membrane in both bryophytes. In Arabidopsis root epidermis, bryophytic PINs show no defined polarity. Pharmacological interference revealed a strong cytoskeleton dependence of bryophytic but not Arabidopsis PIN polarization. The divergence of PIN polarization and trafficking is also observed within the bryophyte clade and between tissues of individual species. These results collectively reveal a divergence of PIN trafficking and polarity mechanisms throughout land plant evolution and a co-evolution of PIN sequence-based and cell-based polarity mechanisms."}],"language":[{"iso":"eng"}],"citation":{"chicago":"Tang, Han, KJ Lu, Y Zhang, YL Cheng, SL Tu, and Jiří Friml. “Divergence of Trafficking and Polarization Mechanisms for PIN Auxin Transporters during Land Plant Evolution.” Plant Communications. Elsevier, 2024. https://doi.org/10.1016/j.xplc.2023.100669.","mla":"Tang, Han, et al. “Divergence of Trafficking and Polarization Mechanisms for PIN Auxin Transporters during Land Plant Evolution.” Plant Communications, vol. 5, no. 1, 100669, Elsevier, 2024, doi:10.1016/j.xplc.2023.100669.","short":"H. Tang, K. Lu, Y. Zhang, Y. Cheng, S. Tu, J. Friml, Plant Communications 5 (2024).","apa":"Tang, H., Lu, K., Zhang, Y., Cheng, Y., Tu, S., & Friml, J. (2024). Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution. Plant Communications. Elsevier. https://doi.org/10.1016/j.xplc.2023.100669","ista":"Tang H, Lu K, Zhang Y, Cheng Y, Tu S, Friml J. 2024. Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution. Plant Communications. 5(1), 100669.","ama":"Tang H, Lu K, Zhang Y, Cheng Y, Tu S, Friml J. Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution. Plant Communications. 2024;5(1). doi:10.1016/j.xplc.2023.100669","ieee":"H. Tang, K. Lu, Y. Zhang, Y. Cheng, S. Tu, and J. Friml, “Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution,” Plant Communications, vol. 5, no. 1. Elsevier, 2024."},"DOAJ_listed":"1","article_type":"original","ec_funded":1,"OA_place":"publisher","intvolume":" 5","ddc":["580"],"date_updated":"2025-08-05T13:27:26Z","OA_type":"gold","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985"}],"article_processing_charge":"Yes","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["2590-3462"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution","oa":1,"day":"08","department":[{"_id":"JiFr"}],"quality_controlled":"1","_id":"14251","date_published":"2024-01-08T00:00:00Z","article_number":"100669","isi":1,"file":[{"file_size":2825565,"checksum":"edbc44c6d4a394d2bf70f92fdbb08f0a","success":1,"date_updated":"2024-01-30T12:59:57Z","file_id":"14911","file_name":"2023_PlantCommunications_Tang.pdf","relation":"main_file","creator":"dernst","access_level":"open_access","date_created":"2024-01-30T12:59:57Z","content_type":"application/pdf"}],"acknowledgement":"This work was supported by the ERC grant (PR1023ERC02) to H. T. and J. F., and by the ministry of science and technology (grant number 110-2636-B-005-001) to K. J. L.","doi":"10.1016/j.xplc.2023.100669","publisher":"Elsevier"},{"year":"2024","publication_status":"published","file_date_updated":"2025-01-09T07:48:01Z","related_material":{"link":[{"url":"https://github.com/danzllab/CATS","relation":"software"}],"record":[{"status":"deleted","id":"18660","relation":"dissertation_contains"},{"id":"13126","status":"public","relation":"research_data"},{"status":"public","id":"18674","relation":"dissertation_contains"}]},"volume":42,"month":"07","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"E-Lib"}],"author":[{"orcid":"0000-0003-3862-1235","first_name":"Julia M","last_name":"Michalska","full_name":"Michalska, Julia M","id":"443DB6DE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Julia","last_name":"Lyudchik","full_name":"Lyudchik, Julia","id":"46E28B80-F248-11E8-B48F-1D18A9856A87"},{"id":"39BDC62C-F248-11E8-B48F-1D18A9856A87","full_name":"Velicky, Philipp","last_name":"Velicky","first_name":"Philipp","orcid":"0000-0002-2340-7431"},{"last_name":"Korinkova","first_name":"Hana","id":"ee3cb6ca-ec98-11ea-ae11-ff703e2254ed","full_name":"Korinkova, Hana"},{"orcid":"0000-0002-8698-3823","first_name":"Jake","last_name":"Watson","full_name":"Watson, Jake","id":"63836096-4690-11EA-BD4E-32803DDC885E"},{"last_name":"Cenameri","first_name":"Alban","id":"9ac8f577-2357-11eb-997a-e566c5550886","full_name":"Cenameri, Alban"},{"full_name":"Sommer, Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","last_name":"Sommer","orcid":"0000-0003-1216-9105","first_name":"Christoph M"},{"orcid":"0000-0002-3183-8207","first_name":"Nicole","last_name":"Amberg","full_name":"Amberg, Nicole","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87"},{"id":"41CB84B2-F248-11E8-B48F-1D18A9856A87","full_name":"Venturino, Alessandro","last_name":"Venturino","first_name":"Alessandro","orcid":"0000-0003-2356-9403"},{"last_name":"Roessler","first_name":"Karl","full_name":"Roessler, Karl"},{"full_name":"Czech, Thomas","first_name":"Thomas","last_name":"Czech"},{"last_name":"Höftberger","first_name":"Romana","full_name":"Höftberger, Romana"},{"first_name":"Sandra","orcid":"0000-0001-8635-0877","last_name":"Siegert","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","full_name":"Siegert, Sandra"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","first_name":"Gaia","orcid":"0000-0002-7673-7178","last_name":"Novarino"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","first_name":"Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas"},{"last_name":"Danzl","orcid":"0000-0001-8559-3973","first_name":"Johann G","full_name":"Danzl, Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87"}],"pmid":1,"page":"1051-1064","OA_place":"publisher","intvolume":" 42","date_updated":"2026-04-14T08:34:35Z","ddc":["570"],"project":[{"_id":"265CB4D0-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Optical control of synaptic function via adhesion molecules","grant_number":"I03600"},{"grant_number":"W1232","name":"Molecular Drug Targets","_id":"2548AE96-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"grant_number":"Z00312","name":"Synaptic communication in neuronal microcircuits","call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425"},{"name":"High content imaging to decode human immune cell interactions in health and allergic disease","_id":"23889792-32DE-11EA-91FC-C7463DDC885E","grant_number":"LS18-022"},{"_id":"25444568-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","grant_number":"715508"},{"grant_number":"692692","call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"},{"grant_number":"101026635","call_identifier":"H2020","name":"Synaptic computations of the hippocampal CA3 circuitry","_id":"fc2be41b-9c52-11eb-aca3-faa90aa144e9"}],"OA_type":"hybrid","publication":"Nature Biotechnology","scopus_import":"1","date_created":"2023-09-03T22:01:15Z","oa_version":"Published Version","type":"journal_article","corr_author":"1","abstract":[{"lang":"eng","text":"Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease."}],"status":"public","external_id":{"isi":["001065254200001"],"pmid":["37653226"]},"has_accepted_license":"1","ec_funded":1,"article_type":"original","citation":{"chicago":"Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake Watson, Alban Cenameri, Christoph M Sommer, et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” Nature Biotechnology. Springer Nature, 2024. https://doi.org/10.1038/s41587-023-01911-8.","ista":"Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer CM, Amberg N, Venturino A, Roessler K, Czech T, Höftberger R, Siegert S, Novarino G, Jonas PM, Danzl JG. 2024. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 42, 1051–1064.","ieee":"J. M. Michalska et al., “Imaging brain tissue architecture across millimeter to nanometer scales,” Nature Biotechnology, vol. 42. Springer Nature, pp. 1051–1064, 2024.","ama":"Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 2024;42:1051-1064. doi:10.1038/s41587-023-01911-8","apa":"Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri, A., … Danzl, J. G. (2024). Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. Springer Nature. https://doi.org/10.1038/s41587-023-01911-8","short":"J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri, C.M. Sommer, N. Amberg, A. Venturino, K. Roessler, T. Czech, R. Höftberger, S. Siegert, G. Novarino, P.M. Jonas, J.G. Danzl, Nature Biotechnology 42 (2024) 1051–1064.","mla":"Michalska, Julia M., et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” Nature Biotechnology, vol. 42, Springer Nature, 2024, pp. 1051–64, doi:10.1038/s41587-023-01911-8."},"language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"Imaging brain tissue architecture across millimeter to nanometer scales","day":"01","department":[{"_id":"SaSi"},{"_id":"GaNo"},{"_id":"PeJo"},{"_id":"JoDa"},{"_id":"Bio"},{"_id":"RySh"}],"article_processing_charge":"Yes (in subscription journal)","publication_identifier":{"issn":["1087-0156"],"eissn":["1546-1696"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"isi":1,"doi":"10.1038/s41587-023-01911-8","acknowledgement":"We thank J. Vorlaufer, N. Agudelo-Dueñas, W. Jahr and A. Wartak for microscope maintenance and troubleshooting; C. Kreuzinger, A. Freeman and I. Erber for technical assistance; and M. Tomschik for support with obtaining human samples. We gratefully acknowledge E. Miguel for setting up webKnossos and M. Šuplata for computational support and hardware control. We are grateful to R. Shigemoto and B. Bickel for generous support and M. Sixt and S. Boyd (Stanford University) for discussions and critical reading of the paper. PSD95-HaloTag mice were kindly provided by S. Grant (University of Edinburgh). We acknowledge expert support by Institute of Science and Technology Austria’s scientific computing, imaging and optics, preclinical and lab support facilities and by the Miba machine shop and library. We gratefully acknowledge funding by the following sources: Austrian Science Fund (FWF) grant I3600-B27 (J.G.D.); Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and J.M.M.); Austrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award (P.J.); Austrian Science Fund (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27 (R.H.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 715508 – REVERSEAUTISM (G.N.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 692692 – GIANTSYN (P.J.); Marie Skłodowska-Curie Actions Fellowship GA no. 665385 under the EU Horizon 2020 program (J.M.M. and J.L.); and Marie Skłodowska-Curie Actions Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.).","file":[{"date_created":"2025-01-09T07:48:01Z","content_type":"application/pdf","access_level":"open_access","creator":"dernst","relation":"main_file","file_id":"18784","file_name":"2024_NatureBiotech_Michalska.pdf","date_updated":"2025-01-09T07:48:01Z","checksum":"57d5fafb16f02dcb9f7dddb1bd7e2a71","success":1,"file_size":26065165}],"publisher":"Springer Nature","_id":"14257","quality_controlled":"1","date_published":"2024-07-01T00:00:00Z"},{"month":"07","volume":72,"publication_status":"published","file_date_updated":"2024-07-22T09:43:19Z","year":"2024","page":"29-48","pmid":1,"author":[{"last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Garber","first_name":"Alexey","full_name":"Garber, Alexey"},{"full_name":"Ghafari, Mohadese","last_name":"Ghafari","first_name":"Mohadese"},{"last_name":"Heiss","orcid":"0000-0002-1780-2689","first_name":"Teresa","full_name":"Heiss, Teresa","id":"4879BB4E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Saghafian, Morteza","id":"f86f7148-b140-11ec-9577-95435b8df824","first_name":"Morteza","last_name":"Saghafian"}],"project":[{"name":"Alpha Shape Theory Extended","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"788183"},{"grant_number":"Z00342","call_identifier":"FWF","name":"Mathematics, Computer Science","_id":"268116B8-B435-11E9-9278-68D0E5697425"},{"grant_number":"I02979-N35","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","name":"Persistence and stability of geometric complexes","call_identifier":"FWF"}],"date_updated":"2025-04-23T08:41:59Z","arxiv":1,"ddc":["510"],"intvolume":" 72","article_type":"original","citation":{"chicago":"Edelsbrunner, Herbert, Alexey Garber, Mohadese Ghafari, Teresa Heiss, and Morteza Saghafian. “On Angles in Higher Order Brillouin Tessellations and Related Tilings in the Plane.” Discrete and Computational Geometry. Springer Nature, 2024. https://doi.org/10.1007/s00454-023-00566-1.","mla":"Edelsbrunner, Herbert, et al. “On Angles in Higher Order Brillouin Tessellations and Related Tilings in the Plane.” Discrete and Computational Geometry, vol. 72, Springer Nature, 2024, pp. 29–48, doi:10.1007/s00454-023-00566-1.","short":"H. Edelsbrunner, A. Garber, M. Ghafari, T. Heiss, M. Saghafian, Discrete and Computational Geometry 72 (2024) 29–48.","apa":"Edelsbrunner, H., Garber, A., Ghafari, M., Heiss, T., & Saghafian, M. (2024). On angles in higher order Brillouin tessellations and related tilings in the plane. Discrete and Computational Geometry. Springer Nature. https://doi.org/10.1007/s00454-023-00566-1","ama":"Edelsbrunner H, Garber A, Ghafari M, Heiss T, Saghafian M. On angles in higher order Brillouin tessellations and related tilings in the plane. Discrete and Computational Geometry. 2024;72:29-48. doi:10.1007/s00454-023-00566-1","ieee":"H. Edelsbrunner, A. Garber, M. Ghafari, T. Heiss, and M. Saghafian, “On angles in higher order Brillouin tessellations and related tilings in the plane,” Discrete and Computational Geometry, vol. 72. Springer Nature, pp. 29–48, 2024.","ista":"Edelsbrunner H, Garber A, Ghafari M, Heiss T, Saghafian M. 2024. On angles in higher order Brillouin tessellations and related tilings in the plane. Discrete and Computational Geometry. 72, 29–48."},"ec_funded":1,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"For a locally finite set in R2, the order-k Brillouin tessellations form an infinite sequence of convex face-to-face tilings of the plane. If the set is coarsely dense and generic, then the corresponding infinite sequences of minimum and maximum angles are both monotonic in k. As an example, a stationary Poisson point process in R2 is locally finite, coarsely dense, and generic with probability one. For such a set, the distributions of angles in the Voronoi tessellations, Delaunay mosaics, and Brillouin tessellations are independent of the order and can be derived from the formula for angles in order-1 Delaunay mosaics given by Miles (Math. Biosci. 6, 85–127 (1970))."}],"has_accepted_license":"1","external_id":{"arxiv":["2204.01076"],"isi":["001060727600004"],"pmid":["39610762"]},"status":"public","scopus_import":"1","oa_version":"Published Version","date_created":"2023-09-17T22:01:10Z","publication":"Discrete and Computational Geometry","type":"journal_article","corr_author":"1","department":[{"_id":"HeEd"}],"day":"01","oa":1,"title":"On angles in higher order Brillouin tessellations and related tilings in the plane","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1432-0444"],"issn":["0179-5376"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"Yes (via OA deal)","publisher":"Springer Nature","isi":1,"file":[{"file_size":892019,"file_name":"2024_DiscreteComputGeom_Edelsbrunner.pdf","file_id":"17301","date_updated":"2024-07-22T09:43:19Z","success":1,"checksum":"b207b4e00f904e8ea8a30e24f0251f79","access_level":"open_access","creator":"dernst","relation":"main_file","date_created":"2024-07-22T09:43:19Z","content_type":"application/pdf"}],"doi":"10.1007/s00454-023-00566-1","acknowledgement":"Work by all authors but A. Garber is supported by the European Research Council (ERC), Grant No. 788183, by the Wittgenstein Prize, Austrian Science Fund (FWF), Grant No. Z 342-N31, and by the DFG Collaborative Research Center TRR 109, Austrian Science Fund (FWF), Grant No. I 02979-N35. Work by A. Garber is partially supported by the Alexander von Humboldt Foundation.","quality_controlled":"1","_id":"14345","date_published":"2024-07-01T00:00:00Z"},{"department":[{"_id":"ToHe"}],"day":"01","title":"Symbolic control for stochastic systems via finite parity games","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["1751-570X"]},"article_processing_charge":"Yes (in subscription journal)","publisher":"Elsevier","acknowledgement":"We thank Daniel Hausmann and Nir Piterman for their valuable comments on an earlier version of the manuscript of our other paper [22] where we present, among other things, the parity fixpoint for 2 1/2-player games (for a slightly more general class of games) with a different and indirect proof of correctness. Based on their comments we observed that, unlike the other fixpoints that we present in [22], the parity fixpoint does not follow the exact same structure as its counterpart for 2-player games, which we also use int his paper.\r\nWe also thank Thejaswini Raghavan for observing that our symbolic parity fixpoint algorithm can be solved in quasi-polynomial time using recent improved algorithms for solving \r\n-calculus expressions. This significantly improved the complexity bounds of our algorithm in this paper.\r\nThe work of R. Majumdar and A.-K. Schmuck are partially supported by DFG, Germany project 389792660 TRR 248–CPEC. A.-K. Schmuck is additionally funded through DFG, Germany project (SCHM 3541/1-1). K. Mallik is supported by the ERC project ERC-2020-AdG 101020093. S. Soudjani is supported by the following projects: EPSRC EP/V043676/1, EIC 101070802, and ERC 101089047.","isi":1,"doi":"10.1016/j.nahs.2023.101430","file":[{"date_created":"2024-07-16T10:26:41Z","content_type":"application/pdf","relation":"main_file","creator":"dernst","access_level":"open_access","success":1,"checksum":"4eab70274d1004ea411f7f0e74c033ac","date_updated":"2024-07-16T10:26:41Z","file_id":"17258","file_name":"2024_NonlinearAnalysis_Majumdar.pdf","file_size":1787569}],"article_number":"101430","quality_controlled":"1","_id":"14400","date_published":"2024-02-01T00:00:00Z","month":"02","volume":51,"issue":"2","publication_status":"published","file_date_updated":"2024-07-16T10:26:41Z","year":"2024","author":[{"first_name":"Rupak","last_name":"Majumdar","full_name":"Majumdar, Rupak"},{"id":"0834ff3c-6d72-11ec-94e0-b5b0a4fb8598","full_name":"Mallik, Kaushik","first_name":"Kaushik","orcid":"0000-0001-9864-7475","last_name":"Mallik"},{"last_name":"Schmuck","first_name":"Anne Kathrin","full_name":"Schmuck, Anne Kathrin"},{"full_name":"Soudjani, Sadegh","first_name":"Sadegh","last_name":"Soudjani"}],"project":[{"_id":"62781420-2b32-11ec-9570-8d9b63373d4d","call_identifier":"H2020","name":"Vigilant Algorithmic Monitoring of Software","grant_number":"101020093"}],"arxiv":1,"ddc":["000"],"date_updated":"2025-04-14T07:55:55Z","intvolume":" 51","language":[{"iso":"eng"}],"citation":{"apa":"Majumdar, R., Mallik, K., Schmuck, A. K., & Soudjani, S. (2024). Symbolic control for stochastic systems via finite parity games. Nonlinear Analysis: Hybrid Systems. Elsevier. https://doi.org/10.1016/j.nahs.2023.101430","ieee":"R. Majumdar, K. Mallik, A. K. Schmuck, and S. Soudjani, “Symbolic control for stochastic systems via finite parity games,” Nonlinear Analysis: Hybrid Systems, vol. 51, no. 2. Elsevier, 2024.","ama":"Majumdar R, Mallik K, Schmuck AK, Soudjani S. Symbolic control for stochastic systems via finite parity games. Nonlinear Analysis: Hybrid Systems. 2024;51(2). doi:10.1016/j.nahs.2023.101430","ista":"Majumdar R, Mallik K, Schmuck AK, Soudjani S. 2024. Symbolic control for stochastic systems via finite parity games. Nonlinear Analysis: Hybrid Systems. 51(2), 101430.","mla":"Majumdar, Rupak, et al. “Symbolic Control for Stochastic Systems via Finite Parity Games.” Nonlinear Analysis: Hybrid Systems, vol. 51, no. 2, 101430, Elsevier, 2024, doi:10.1016/j.nahs.2023.101430.","short":"R. Majumdar, K. Mallik, A.K. Schmuck, S. Soudjani, Nonlinear Analysis: Hybrid Systems 51 (2024).","chicago":"Majumdar, Rupak, Kaushik Mallik, Anne Kathrin Schmuck, and Sadegh Soudjani. “Symbolic Control for Stochastic Systems via Finite Parity Games.” Nonlinear Analysis: Hybrid Systems. Elsevier, 2024. https://doi.org/10.1016/j.nahs.2023.101430."},"article_type":"original","ec_funded":1,"status":"public","external_id":{"isi":["001093188100001"],"arxiv":["2101.00834"]},"has_accepted_license":"1","abstract":[{"lang":"eng","text":"We consider the problem of computing the maximal probability of satisfying an \r\n-regular specification for stochastic, continuous-state, nonlinear systems evolving in discrete time. The problem reduces, after automata-theoretic constructions, to finding the maximal probability of satisfying a parity condition on a (possibly hybrid) state space. While characterizing the exact satisfaction probability is open, we show that a lower bound on this probability can be obtained by (I) computing an under-approximation of the qualitative winning region, i.e., states from which the parity condition can be enforced almost surely, and (II) computing the maximal probability of reaching this qualitative winning region.\r\nThe heart of our approach is a technique to symbolically compute the under-approximation of the qualitative winning region in step (I) via a finite-state abstraction of the original system as a \r\n-player parity game. Our abstraction procedure uses only the support of the probabilistic evolution; it does not use precise numerical transition probabilities. We prove that the winning set in the abstract -player game induces an under-approximation of the qualitative winning region in the original synthesis problem, along with a policy to solve it. By combining these contributions with (a) a symbolic fixpoint algorithm to solve \r\n-player games and (b) existing techniques for reachability policy synthesis in stochastic nonlinear systems, we get an abstraction-based algorithm for finding a lower bound on the maximal satisfaction probability.\r\nWe have implemented the abstraction-based algorithm in Mascot-SDS, where we combined the outlined abstraction step with our tool Genie (Majumdar et al., 2023) that solves \r\n-player parity games (through a reduction to Rabin games) more efficiently than existing algorithms. We evaluated our implementation on the nonlinear model of a perturbed bistable switch from the literature. We show empirically that the lower bound on the winning region computed by our approach is precise, by comparing against an over-approximation of the qualitative winning region. Moreover, our implementation outperforms a recently proposed tool for solving this problem by a large margin."}],"type":"journal_article","corr_author":"1","scopus_import":"1","date_created":"2023-10-08T22:01:15Z","oa_version":"Published Version","publication":"Nonlinear Analysis: Hybrid Systems"},{"year":"2024","publication_status":"published","volume":188,"month":"04","author":[{"orcid":"0000-0002-4901-7992","first_name":"Giorgio","last_name":"Cipolloni","full_name":"Cipolloni, Giorgio","id":"42198EFA-F248-11E8-B48F-1D18A9856A87"},{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","last_name":"Erdös","first_name":"László","orcid":"0000-0001-5366-9603"},{"orcid":"0000-0002-2904-1856","first_name":"Dominik J","last_name":"Schröder","full_name":"Schröder, Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87"}],"page":"1131-1182","intvolume":" 188","arxiv":1,"date_updated":"2025-08-05T13:28:15Z","project":[{"name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331"}],"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2210.12060","open_access":"1"}],"type":"journal_article","oa_version":"Preprint","scopus_import":"1","publication":"Probability Theory and Related Fields","date_created":"2023-10-08T22:01:17Z","external_id":{"isi":["001118972500001"],"arxiv":["2210.12060"]},"status":"public","abstract":[{"text":"We prove that the mesoscopic linear statistics ∑if(na(σi−z0)) of the eigenvalues {σi}i of large n×n non-Hermitian random matrices with complex centred i.i.d. entries are asymptotically Gaussian for any H20-functions f around any point z0 in the bulk of the spectrum on any mesoscopic scale 0Probability Theory and Related Fields. Springer Nature, 2024. https://doi.org/10.1007/s00440-023-01229-1.","apa":"Cipolloni, G., Erdös, L., & Schröder, D. J. (2024). Mesoscopic central limit theorem for non-Hermitian random matrices. Probability Theory and Related Fields. Springer Nature. https://doi.org/10.1007/s00440-023-01229-1","ista":"Cipolloni G, Erdös L, Schröder DJ. 2024. Mesoscopic central limit theorem for non-Hermitian random matrices. Probability Theory and Related Fields. 188, 1131–1182.","ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “Mesoscopic central limit theorem for non-Hermitian random matrices,” Probability Theory and Related Fields, vol. 188. Springer Nature, pp. 1131–1182, 2024.","ama":"Cipolloni G, Erdös L, Schröder DJ. Mesoscopic central limit theorem for non-Hermitian random matrices. Probability Theory and Related Fields. 2024;188:1131-1182. doi:10.1007/s00440-023-01229-1","mla":"Cipolloni, Giorgio, et al. “Mesoscopic Central Limit Theorem for Non-Hermitian Random Matrices.” Probability Theory and Related Fields, vol. 188, Springer Nature, 2024, pp. 1131–82, doi:10.1007/s00440-023-01229-1.","short":"G. Cipolloni, L. Erdös, D.J. Schröder, Probability Theory and Related Fields 188 (2024) 1131–1182."},"ec_funded":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Mesoscopic central limit theorem for non-Hermitian random matrices","oa":1,"day":"01","department":[{"_id":"LaEr"}],"article_processing_charge":"No","publication_identifier":{"issn":["0178-8051"],"eissn":["1432-2064"]},"isi":1,"acknowledgement":"The authors are grateful to Joscha Henheik for his help with the formulas in Appendix B.\r\nLászló Erdős supported by ERC Advanced Grant “RMTBeyond” No. 101020331. Dominik Schröder supported by the SNSF Ambizione Grant PZ00P2 209089.","doi":"10.1007/s00440-023-01229-1","publisher":"Springer Nature","date_published":"2024-04-01T00:00:00Z","_id":"14408","quality_controlled":"1"},{"intvolume":" 36","date_updated":"2025-04-15T06:36:40Z","project":[{"name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery","_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A"}],"scopus_import":"1","date_created":"2023-10-17T10:53:56Z","oa_version":"None","publication":"Advanced Materials","type":"journal_article","abstract":[{"text":"Low‐cost, safe, and environmental‐friendly rechargeable aqueous zinc‐ion batteries (ZIBs) are promising as next‐generation energy storage devices for wearable electronics among other applications. However, sluggish ionic transport kinetics and the unstable electrode structure during ionic insertion/extraction hampers their deployment. Herein, we propose a new cathode material based on a layered metal chalcogenide (LMC), bismuth telluride (Bi2Te3), coated with polypyrrole (PPy). Taking advantage of the PPy coating, the Bi2Te3@PPy composite presents strong ionic absorption affinity, high oxidation resistance, and high structural stability. The ZIBs based on Bi2Te3@PPy cathodes exhibit high capacities and ultra‐long lifespans of over 5000 cycles. They also present outstanding stability even under bending. In addition, we analyze here the reaction mechanism using in situ X‐ray diffraction, X‐ray photoelectron spectroscopy, and computational tools and demonstrate that, in the aqueous system, Zn2+ is not inserted into the cathode as previously assumed. In contrast, proton charge storage dominates the process. Overall, this work not only shows the great potential of LMCs as ZIBs cathode materials and the advantages of PPy coating, but also clarifies the charge/discharge mechanism in rechargeable ZIBs based on LMCs.","lang":"eng"}],"status":"public","external_id":{"isi":["001085681000001"],"pmid":["37555532"]},"article_type":"original","citation":{"mla":"Zeng, Guifang, et al. “A Layered Bi2Te3@PPy Cathode for Aqueous Zinc Ion Batteries: Mechanism and Application in Printed Flexible Batteries.” Advanced Materials, vol. 36, no. 1, 2305128, Wiley, 2024, doi:10.1002/adma.202305128.","short":"G. Zeng, Q. Sun, S. Horta, S. Wang, X. Lu, C. Zhang, J. Li, J. Li, L. Ci, Y. Tian, M. Ibáñez, A. Cabot, Advanced Materials 36 (2024).","apa":"Zeng, G., Sun, Q., Horta, S., Wang, S., Lu, X., Zhang, C., … Cabot, A. (2024). A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries. Advanced Materials. Wiley. https://doi.org/10.1002/adma.202305128","ama":"Zeng G, Sun Q, Horta S, et al. A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries. Advanced Materials. 2024;36(1). doi:10.1002/adma.202305128","ista":"Zeng G, Sun Q, Horta S, Wang S, Lu X, Zhang C, Li J, Li J, Ci L, Tian Y, Ibáñez M, Cabot A. 2024. A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries. Advanced Materials. 36(1), 2305128.","ieee":"G. Zeng et al., “A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries,” Advanced Materials, vol. 36, no. 1. Wiley, 2024.","chicago":"Zeng, Guifang, Qing Sun, Sharona Horta, Shang Wang, Xuan Lu, Chaoyue Zhang, Jing Li, et al. “A Layered Bi2Te3@PPy Cathode for Aqueous Zinc Ion Batteries: Mechanism and Application in Printed Flexible Batteries.” Advanced Materials. Wiley, 2024. https://doi.org/10.1002/adma.202305128."},"language":[{"iso":"eng"}],"year":"2024","publication_status":"published","issue":"1","volume":36,"month":"01","acknowledged_ssus":[{"_id":"EM-Fac"}],"author":[{"last_name":"Zeng","first_name":"Guifang","full_name":"Zeng, Guifang"},{"last_name":"Sun","first_name":"Qing","full_name":"Sun, Qing"},{"first_name":"Sharona","last_name":"Horta","id":"03a7e858-01b1-11ec-8b71-99ae6c4a05bc","full_name":"Horta, Sharona"},{"first_name":"Shang","last_name":"Wang","full_name":"Wang, Shang"},{"last_name":"Lu","first_name":"Xuan","full_name":"Lu, Xuan"},{"first_name":"Chaoyue","last_name":"Zhang","full_name":"Zhang, Chaoyue"},{"first_name":"Jing","last_name":"Li","full_name":"Li, Jing"},{"full_name":"Li, Junshan","last_name":"Li","first_name":"Junshan"},{"last_name":"Ci","first_name":"Lijie","full_name":"Ci, Lijie"},{"first_name":"Yanhong","last_name":"Tian","full_name":"Tian, Yanhong"},{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","full_name":"Ibáñez, Maria","last_name":"Ibáñez","first_name":"Maria","orcid":"0000-0001-5013-2843"},{"full_name":"Cabot, Andreu","last_name":"Cabot","first_name":"Andreu"}],"pmid":1,"doi":"10.1002/adma.202305128","isi":1,"acknowledgement":"G.Z. and Q.S. contributed equally to this work. This work was supported by the National Natural Science Foundation of China (52105329, 52175300) and the Heilongjiang Provincial Natural Science Foundation of China (LH2022E059). G.Z., X.L., and C.Z. thank the China Scholarship Council (CSC) for the scholarship support. This research was supported by the Scientific Service Units of ISTA through resources provided by the Electron Microscopy Facility. S.H. and M.I. acknowledge funding by ISTA and Werner Siemens.","publisher":"Wiley","_id":"14435","date_published":"2024-01-04T00:00:00Z","quality_controlled":"1","article_number":"2305128","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries","keyword":["Mechanical Engineering","Mechanics of Materials","General Materials Science"],"day":"04","department":[{"_id":"MaIb"}],"article_processing_charge":"No","publication_identifier":{"eissn":["1521-4095"],"issn":["0935-9648"]}},{"author":[{"full_name":"Bieleszová, Kristýna","last_name":"Bieleszová","first_name":"Kristýna"},{"full_name":"Hladík, Pavel","first_name":"Pavel","last_name":"Hladík"},{"first_name":"Martin","last_name":"Kubala","full_name":"Kubala, Martin"},{"full_name":"Napier, Richard","last_name":"Napier","first_name":"Richard"},{"full_name":"Brunoni, Federica","last_name":"Brunoni","first_name":"Federica"},{"full_name":"Gelová, Zuzana","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","last_name":"Gelová","orcid":"0000-0003-4783-1752","first_name":"Zuzana"},{"id":"7c417475-8972-11ed-ae7b-8b674ca26986","full_name":"Fiedler, Lukas","first_name":"Lukas","last_name":"Fiedler"},{"last_name":"Kulich","first_name":"Ivan","id":"57a1567c-8314-11eb-9063-c9ddc3451a54","full_name":"Kulich, Ivan"},{"last_name":"Strnad","first_name":"Miroslav","full_name":"Strnad, Miroslav"},{"last_name":"Doležal","first_name":"Karel","full_name":"Doležal, Karel"},{"full_name":"Novák, Ondřej","first_name":"Ondřej","last_name":"Novák"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml"},{"full_name":"Žukauskaitė, Asta","last_name":"Žukauskaitė","first_name":"Asta"}],"page":"589-602","year":"2024","publication_status":"published","file_date_updated":"2024-07-16T08:13:24Z","volume":102,"month":"04","type":"journal_article","scopus_import":"1","oa_version":"Published Version","publication":"Plant Growth Regulation","date_created":"2023-10-22T22:01:15Z","external_id":{"isi":["001084334300001"]},"status":"public","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Auxin belongs among major phytohormones and governs multiple aspects of plant growth and development. The establishment of auxin concentration gradients, determines, among other processes, plant organ positioning and growth responses to environmental stimuli.\r\nHerein we report the synthesis of new NBD- or DNS-labelled IAA derivatives and the elucidation of their biological activity, fluorescence properties and subcellular accumulation patterns in planta. These novel compounds did not show auxin-like activity, but instead antagonized physiological auxin effects. The DNS-labelled derivatives FL5 and FL6 showed strong anti-auxin activity in roots and hypocotyls, which also occurred at the level of gene transcription as confirmed by quantitative PCR analysis. The auxin antagonism of our derivatives was further demonstrated in vitro using an SPR-based binding assay. The NBD-labelled compound FL4 with the best fluorescence properties proved to be unsuitable to study auxin accumulation patterns in planta. On the other hand, the strongest anti-auxin activity possessing compounds FL5 and FL6 could be useful to study binding mechanisms to auxin receptors and for manipulations of auxin-regulated processes."}],"language":[{"iso":"eng"}],"article_type":"original","citation":{"ista":"Bieleszová K, Hladík P, Kubala M, Napier R, Brunoni F, Gelová Z, Fiedler L, Kulich I, Strnad M, Doležal K, Novák O, Friml J, Žukauskaitė A. 2024. New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana. Plant Growth Regulation. 102, 589–602.","ama":"Bieleszová K, Hladík P, Kubala M, et al. New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana. Plant Growth Regulation. 2024;102:589-602. doi:10.1007/s10725-023-01083-0","ieee":"K. Bieleszová et al., “New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana,” Plant Growth Regulation, vol. 102. Springer Nature, pp. 589–602, 2024.","apa":"Bieleszová, K., Hladík, P., Kubala, M., Napier, R., Brunoni, F., Gelová, Z., … Žukauskaitė, A. (2024). New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana. Plant Growth Regulation. Springer Nature. https://doi.org/10.1007/s10725-023-01083-0","short":"K. Bieleszová, P. Hladík, M. Kubala, R. Napier, F. Brunoni, Z. Gelová, L. Fiedler, I. Kulich, M. Strnad, K. Doležal, O. Novák, J. Friml, A. Žukauskaitė, Plant Growth Regulation 102 (2024) 589–602.","mla":"Bieleszová, Kristýna, et al. “New Fluorescent Auxin Derivatives: Anti-Auxin Activity and Accumulation Patterns in Arabidopsis Thaliana.” Plant Growth Regulation, vol. 102, Springer Nature, 2024, pp. 589–602, doi:10.1007/s10725-023-01083-0.","chicago":"Bieleszová, Kristýna, Pavel Hladík, Martin Kubala, Richard Napier, Federica Brunoni, Zuzana Gelová, Lukas Fiedler, et al. “New Fluorescent Auxin Derivatives: Anti-Auxin Activity and Accumulation Patterns in Arabidopsis Thaliana.” Plant Growth Regulation. Springer Nature, 2024. https://doi.org/10.1007/s10725-023-01083-0."},"intvolume":" 102","ddc":["580"],"date_updated":"2024-07-16T08:13:39Z","article_processing_charge":"Yes (via OA deal)","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["0167-6903"],"eissn":["1573-5087"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana","oa":1,"day":"01","department":[{"_id":"JiFr"}],"_id":"14447","quality_controlled":"1","date_published":"2024-04-01T00:00:00Z","isi":1,"file":[{"access_level":"open_access","creator":"dernst","relation":"main_file","content_type":"application/pdf","date_created":"2024-07-16T08:13:24Z","file_size":2847929,"file_id":"17252","file_name":"2024_PlantGrowthReg_Bieleszova.pdf","date_updated":"2024-07-16T08:13:24Z","success":1,"checksum":"e63271b1d57c1f03c1d993fd62cba59c"}],"acknowledgement":"The authors would like to thank Karolína Kubiasová and Iñigo Saiz-Fernández for valuable scientific discussions. Open access publishing supported by the National Technical Library in Prague. This work was supported by the Palacký University Olomouc Young Researcher Grant Competition (JG_2020_002), by the Internal Grant Agency of Palacký University Olomouc (IGA_PrF_2023_016, IGA_PrF_2023_031), by the Ministry of Education, Youth and Sports of the Czech Republic through the European Regional Development Fund-Project Plants as a tool for sustainable global development (CZ.02.1.01/0.0/0.0/16_019/0000827) and the project Support of mobility at Palacký University Olomouc II. (CZ.02.2.69/0.0/0.0/18_053/0016919). The Biacore T200 SPR instrument was provided by the WISB Research Technology Facility within the School of Life Sciences, University of Warwick.","doi":"10.1007/s10725-023-01083-0","publisher":"Springer Nature"},{"volume":36,"issue":"2","month":"01","year":"2024","file_date_updated":"2024-07-16T08:08:54Z","publication_status":"published","pmid":1,"page":"617-637","author":[{"last_name":"Cornalba","orcid":"0000-0002-6269-5149","first_name":"Federico","full_name":"Cornalba, Federico","id":"2CEB641C-A400-11E9-A717-D712E6697425"},{"full_name":"Disselkamp, Constantin","first_name":"Constantin","last_name":"Disselkamp"},{"first_name":"Davide","last_name":"Scassola","full_name":"Scassola, Davide"},{"first_name":"Christopher","last_name":"Helf","full_name":"Helf, Christopher"}],"project":[{"_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","name":"Taming Complexity in Partial Differential Systems","grant_number":"F6504"},{"grant_number":"754411","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships"}],"intvolume":" 36","arxiv":1,"ddc":["000"],"date_updated":"2025-04-23T07:39:14Z","language":[{"iso":"eng"}],"citation":{"ista":"Cornalba F, Disselkamp C, Scassola D, Helf C. 2024. Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading. Neural Computing and Applications. 36(2), 617–637.","ieee":"F. Cornalba, C. Disselkamp, D. Scassola, and C. Helf, “Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading,” Neural Computing and Applications, vol. 36, no. 2. Springer Nature, pp. 617–637, 2024.","ama":"Cornalba F, Disselkamp C, Scassola D, Helf C. Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading. Neural Computing and Applications. 2024;36(2):617-637. doi:10.1007/s00521-023-09033-7","apa":"Cornalba, F., Disselkamp, C., Scassola, D., & Helf, C. (2024). Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading. Neural Computing and Applications. Springer Nature. https://doi.org/10.1007/s00521-023-09033-7","short":"F. Cornalba, C. Disselkamp, D. Scassola, C. Helf, Neural Computing and Applications 36 (2024) 617–637.","mla":"Cornalba, Federico, et al. “Multi-Objective Reward Generalization: Improving Performance of Deep Reinforcement Learning for Applications in Single-Asset Trading.” Neural Computing and Applications, vol. 36, no. 2, Springer Nature, 2024, pp. 617–37, doi:10.1007/s00521-023-09033-7.","chicago":"Cornalba, Federico, Constantin Disselkamp, Davide Scassola, and Christopher Helf. “Multi-Objective Reward Generalization: Improving Performance of Deep Reinforcement Learning for Applications in Single-Asset Trading.” Neural Computing and Applications. Springer Nature, 2024. https://doi.org/10.1007/s00521-023-09033-7."},"article_type":"original","ec_funded":1,"corr_author":"1","type":"journal_article","scopus_import":"1","date_created":"2023-10-22T22:01:16Z","oa_version":"Published Version","publication":"Neural Computing and Applications","external_id":{"arxiv":["2203.04579"],"pmid":["38187995"]},"has_accepted_license":"1","status":"public","abstract":[{"text":"We investigate the potential of Multi-Objective, Deep Reinforcement Learning for stock and cryptocurrency single-asset trading: in particular, we consider a Multi-Objective algorithm which generalizes the reward functions and discount factor (i.e., these components are not specified a priori, but incorporated in the learning process). Firstly, using several important assets (BTCUSD, ETHUSDT, XRPUSDT, AAPL, SPY, NIFTY50), we verify the reward generalization property of the proposed Multi-Objective algorithm, and provide preliminary statistical evidence showing increased predictive stability over the corresponding Single-Objective strategy. Secondly, we show that the Multi-Objective algorithm has a clear edge over the corresponding Single-Objective strategy when the reward mechanism is sparse (i.e., when non-null feedback is infrequent over time). Finally, we discuss the generalization properties with respect to the discount factor. The entirety of our code is provided in open-source format.","lang":"eng"}],"day":"01","department":[{"_id":"JuFi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading","oa":1,"article_processing_charge":"Yes (via OA deal)","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["1433-3058"],"issn":["0941-0643"]},"doi":"10.1007/s00521-023-09033-7","acknowledgement":"Open access funding provided by Università degli Studi di Trieste within the CRUI-CARE Agreement. Funding was provided by Austrian Science Fund (Grant No. F65), Horizon 2020 (Grant No. 754411) and Österreichische Forschungsförderungsgesellschaft.","file":[{"content_type":"application/pdf","date_created":"2024-07-16T08:08:54Z","relation":"main_file","creator":"dernst","access_level":"open_access","success":1,"checksum":"04573d8e74c6119b97c2ca0a984e19a1","date_updated":"2024-07-16T08:08:54Z","file_id":"17251","file_name":"2024_NeuralCompApplications_Cornalba.pdf","file_size":4412285}],"publisher":"Springer Nature","_id":"14451","date_published":"2024-01-01T00:00:00Z","quality_controlled":"1"},{"author":[{"first_name":"James","last_name":"Reeve","full_name":"Reeve, James"},{"full_name":"Butlin, Roger K.","last_name":"Butlin","first_name":"Roger K."},{"full_name":"Koch, Eva L.","first_name":"Eva L.","last_name":"Koch"},{"full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","first_name":"Sean","last_name":"Stankowski"},{"last_name":"Faria","first_name":"Rui","full_name":"Faria, Rui"}],"pmid":1,"publication_status":"published","file_date_updated":"2025-01-09T07:52:12Z","year":"2024","month":"12","issue":"24","volume":33,"abstract":[{"text":"Inversions are thought to play a key role in adaptation and speciation, suppressing recombination between diverging populations. Genes influencing adaptive traits cluster in inversions, and changes in inversion frequencies are associated with environmental differences. However, in many organisms, it is unclear if inversions are geographically and taxonomically widespread. The intertidal snail, Littorina saxatilis, is one such example. Strong associations between putative polymorphic inversions and phenotypic differences have been demonstrated between two ecotypes of L. saxatilis in Sweden and inferred elsewhere, but no direct evidence for inversion polymorphism currently exists across the species range. Using whole genome data from 107 snails, most inversion polymorphisms were found to be widespread across the species range. The frequencies of some inversion arrangements were significantly different among ecotypes, suggesting a parallel adaptive role. Many inversions were also polymorphic in the sister species, L. arcana, hinting at an ancient origin.","lang":"eng"}],"status":"public","external_id":{"pmid":["37843465"],"isi":["001085119000001"]},"has_accepted_license":"1","publication":"Molecular Ecology","date_created":"2023-10-29T23:01:17Z","scopus_import":"1","oa_version":"Published Version","type":"journal_article","article_type":"original","citation":{"chicago":"Reeve, James, Roger K. Butlin, Eva L. Koch, Sean Stankowski, and Rui Faria. “Chromosomal Inversion Polymorphisms Are Widespread across the Species Ranges of Rough Periwinkles (Littorina Saxatilis and L. Arcana).” Molecular Ecology. Wiley, 2024. https://doi.org/10.1111/mec.17160.","mla":"Reeve, James, et al. “Chromosomal Inversion Polymorphisms Are Widespread across the Species Ranges of Rough Periwinkles (Littorina Saxatilis and L. Arcana).” Molecular Ecology, vol. 33, no. 24, e17160, Wiley, 2024, doi:10.1111/mec.17160.","short":"J. Reeve, R.K. Butlin, E.L. Koch, S. Stankowski, R. Faria, Molecular Ecology 33 (2024).","apa":"Reeve, J., Butlin, R. K., Koch, E. L., Stankowski, S., & Faria, R. (2024). Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana). Molecular Ecology. Wiley. https://doi.org/10.1111/mec.17160","ieee":"J. Reeve, R. K. Butlin, E. L. Koch, S. Stankowski, and R. Faria, “Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana),” Molecular Ecology, vol. 33, no. 24. Wiley, 2024.","ama":"Reeve J, Butlin RK, Koch EL, Stankowski S, Faria R. Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana). Molecular Ecology. 2024;33(24). doi:10.1111/mec.17160","ista":"Reeve J, Butlin RK, Koch EL, Stankowski S, Faria R. 2024. Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana). Molecular Ecology. 33(24), e17160."},"language":[{"iso":"eng"}],"date_updated":"2025-01-09T07:53:18Z","ddc":["570"],"OA_place":"publisher","intvolume":" 33","OA_type":"hybrid","publication_identifier":{"eissn":["1365-294X"],"issn":["0962-1083"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"Yes (in subscription journal)","oa":1,"title":"Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana)","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"NiBa"}],"day":"01","article_number":"e17160","_id":"14463","date_published":"2024-12-01T00:00:00Z","quality_controlled":"1","publisher":"Wiley","file":[{"creator":"dernst","relation":"main_file","access_level":"open_access","date_created":"2025-01-09T07:52:12Z","content_type":"application/pdf","file_size":6228700,"success":1,"checksum":"686576036663f489c2d079df3079d126","file_id":"18785","file_name":"2024_MolecularEcology_Reeve.pdf","date_updated":"2025-01-09T07:52:12Z"}],"isi":1,"acknowledgement":"We would like to thank members of the Littorina team for their advice and feedback during this project. In particular, we thank Alan Le Moan, who inspired us to look at heterozygosity differences to identify inversions, and Katherine Hearn for helping with the PCA scripts. We thank Edinburgh Genomics for library preparation and sequencing. Sample collections, sequencing and data preparation were supported by the European Research Council (ERC-2015-AdG-693030- BARRIERS) and the Natural Environment Research Council (NE/P001610/1). The analysis was supported by the Swedish Research Council (vetenskaprådet; 2018-03695_VR) and the Portuguese Foundation for Science and Technology (Fundación para a Ciência e Tecnologia) through a research project (PTDC/BIA-EVL/1614/2021) and CEEC contract (2020.00275.CEECIND).","doi":"10.1111/mec.17160"},{"OA_place":"publisher","intvolume":" 121","date_updated":"2025-08-05T13:30:51Z","ddc":["570"],"OA_type":"hybrid","project":[{"grant_number":"771402","call_identifier":"H2020","name":"Epidemics in ant societies on a chip","_id":"2649B4DE-B435-11E9-9278-68D0E5697425"}],"publication":"Proceedings of the National Academy of Sciences of the United States of America","scopus_import":"1","date_created":"2023-10-31T13:30:00Z","oa_version":"Published Version","type":"journal_article","corr_author":"1","abstract":[{"text":"Entire chromosomes are typically only transmitted vertically from one generation to the next. The horizontal transfer of such chromosomes has long been considered improbable, yet gained recent support in several pathogenic fungi where it may affect the fitness or host specificity. To date, it is unknown how these transfers occur, how common they are and whether they can occur between different species. In this study, we show multiple independent instances of horizontal transfers of the same accessory chromosome between two distinct strains of the asexual entomopathogenic fungusMetarhizium robertsiiduring experimental co-infection of its insect host, the Argentine ant. Notably, only the one chromosome – but no other – was transferred from the donor to the recipient strain. The recipient strain, now harboring the accessory chromosome, exhibited a competitive advantage under certain host conditions. By phylogenetic analysis we further demonstrate that the same accessory chromosome was horizontally transferred in a natural environment betweenM. robertsiiand another congeneric insect pathogen,M. guizhouense. Hence horizontal chromosome transfer is not limited to the observed frequent events within species during experimental infections but also occurs naturally across species. The transferred accessory chromosome contains genes that might be involved in its preferential horizontal transfer, encoding putative histones and histone-modifying enzymes, but also putative virulence factors that may support its establishment. Our study reveals that both intra- and interspecies horizontal transfer of entire chromosomes is more frequent than previously assumed, likely representing a not uncommon mechanism for gene exchange.Significance StatementThe enormous success of bacterial pathogens has been attributed to their ability to exchange genetic material between one another. Similarly, in eukaryotes, horizontal transfer of genetic material allowed the spread of virulence factors across species. The horizontal transfer of whole chromosomes could be an important pathway for such exchange of genetic material, but little is known about the origin of transferable chromosomes and how frequently they are exchanged. Here, we show that the transfer of accessory chromosomes - chromosomes that are non-essential but may provide fitness benefits - is common during fungal co-infections and is even possible between distant pathogenic species, highlighting the importance of horizontal gene transfer via chromosome transfer also for the evolution and function of eukaryotic pathogens.","lang":"eng"}],"external_id":{"isi":["001207630200005"],"pmid":["38442176"]},"status":"public","has_accepted_license":"1","article_type":"original","citation":{"mla":"Habig, Michael, et al. “Frequent Horizontal Chromosome Transfer between Asexual Fungal Insect Pathogens.” Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 11, e2316284121, National Academy of Sciences, 2024, doi:10.1073/pnas.2316284121.","short":"M. Habig, A.V. Grasse, J. Müller, E.H. Stukenbrock, H. Leitner, S. Cremer, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).","apa":"Habig, M., Grasse, A. V., Müller, J., Stukenbrock, E. H., Leitner, H., & Cremer, S. (2024). Frequent horizontal chromosome transfer between asexual fungal insect pathogens. Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences. https://doi.org/10.1073/pnas.2316284121","ieee":"M. Habig, A. V. Grasse, J. Müller, E. H. Stukenbrock, H. Leitner, and S. Cremer, “Frequent horizontal chromosome transfer between asexual fungal insect pathogens,” Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 11. National Academy of Sciences, 2024.","ista":"Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. 2024. Frequent horizontal chromosome transfer between asexual fungal insect pathogens. Proceedings of the National Academy of Sciences of the United States of America. 121(11), e2316284121.","ama":"Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. Frequent horizontal chromosome transfer between asexual fungal insect pathogens. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(11). doi:10.1073/pnas.2316284121","chicago":"Habig, Michael, Anna V Grasse, Judith Müller, Eva H. Stukenbrock, Hanna Leitner, and Sylvia Cremer. “Frequent Horizontal Chromosome Transfer between Asexual Fungal Insect Pathogens.” Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 2024. https://doi.org/10.1073/pnas.2316284121."},"ec_funded":1,"language":[{"iso":"eng"}],"year":"2024","file_date_updated":"2024-03-19T09:02:57Z","publication_status":"published","issue":"11","volume":121,"month":"03","author":[{"full_name":"Habig, Michael","first_name":"Michael","last_name":"Habig"},{"first_name":"Anna V","last_name":"Grasse","full_name":"Grasse, Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Müller, Judith","first_name":"Judith","last_name":"Müller"},{"full_name":"Stukenbrock, Eva H.","last_name":"Stukenbrock","first_name":"Eva H."},{"full_name":"Leitner, Hanna","id":"8fc5c6f6-5903-11ec-abad-c83f046253e7","last_name":"Leitner","first_name":"Hanna"},{"full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","orcid":"0000-0002-2193-3868","first_name":"Sylvia"}],"pmid":1,"isi":1,"doi":"10.1073/pnas.2316284121","acknowledgement":"We thank Bernhardt Steinwender, Jorgen Eilenberg, and Nicolai V. Meyling for the fungal strains. We further thank Chengshu Wang for providing the short sequencing reads for M. guizhouense ARESF977 he used for his published genome assembly, and Kristian Ullrich for help in the bioinformatics analysis for methylation pattern in Nanopore reads, and the VBC and the Max Planck Society for the use of their sequencing centers. We thank Barbara Milutinović and Hinrich Schulenburg for discussion, and Tal Dagan and Jens Rolff for comments on a previous version of the manuscript. Fig. 1A was created with BioRender.com. This study received funding by the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (No. 771402; EPIDEMICSonCHIP) to S.C. and by the German Research Foundation (DFG grant HA9263/1-1) to M.H.","file":[{"relation":"main_file","creator":"dernst","access_level":"open_access","date_created":"2024-03-19T09:02:57Z","content_type":"application/pdf","file_size":5750361,"success":1,"checksum":"f5e871db617b682edc71fcd08670dc81","date_updated":"2024-03-19T09:02:57Z","file_name":"2024_PNAS_Habig.pdf","file_id":"15124"}],"publisher":"National Academy of Sciences","quality_controlled":"1","_id":"14478","date_published":"2024-03-12T00:00:00Z","article_number":"e2316284121","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"Frequent horizontal chromosome transfer between asexual fungal insect pathogens","day":"12","department":[{"_id":"SyCr"}],"article_processing_charge":"Yes (in subscription journal)","APC_amount":"3040,36 EUR","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"}},{"type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2023.10.26.564092"}],"publication":"Current Biology","scopus_import":"1","date_created":"2023-10-31T13:30:20Z","oa_version":"Preprint","status":"public","external_id":{"pmid":["38307022"],"isi":["001195884300001"]},"abstract":[{"lang":"eng","text":"In animals, parasitic infections impose significant fitness costs.1,2,3,4,5,6 Infected animals can alter their feeding behavior to resist infection,7,8,9,10,11,12 but parasites can manipulate animal foraging behavior to their own benefits.13,14,15,16 How nutrition influences host-parasite interactions is not well understood, as studies have mainly focused on the host and less on the parasite.9,12,17,18,19,20,21,22,23 We used the nutritional geometry framework24 to investigate the role of amino acids (AA) and carbohydrates (C) in a host-parasite system: the Argentine ant, Linepithema humile, and the entomopathogenic fungus, Metarhizium brunneum. First, using 18 diets varying in AA:C composition, we established that the fungus performed best on the high-amino-acid diet 1:4. Second, we found that the fungus reached this optimal diet when given various diet pairings, revealing its ability to cope with nutritional challenges. Third, we showed that the optimal fungal diet reduced the lifespan of healthy ants when compared with a high-carbohydrate diet but had no effect on infected ants. Fourth, we revealed that infected ant colonies, given a choice between the optimal fungal diet and a high-carbohydrate diet, chose the optimal fungal diet, whereas healthy colonies avoided it. Lastly, by disentangling fungal infection from host immune response, we demonstrated that infected ants foraged on the optimal fungal diet in response to immune activation and not as a result of parasite manipulation. Therefore, we revealed that infected ant colonies chose a diet that is costly for survival in the long term but beneficial in the short term—a form of collective self-medication."}],"language":[{"iso":"eng"}],"citation":{"short":"E. Csata, A. Perez-Escudero, E. Laury, H. Leitner, G. Latil, J. Heinze, S. Simpson, S. Cremer, A. Dussutour, Current Biology 34 (2024) 902–909.e6.","mla":"Csata, Eniko, et al. “Fungal Infection Alters Collective Nutritional Intake of Ant Colonies.” Current Biology, vol. 34, no. 4, Elsevier, 2024, p. 902–909.e6, doi:10.1016/j.cub.2024.01.017.","ista":"Csata E, Perez-Escudero A, Laury E, Leitner H, Latil G, Heinze J, Simpson S, Cremer S, Dussutour A. 2024. Fungal infection alters collective nutritional intake of ant colonies. Current Biology. 34(4), 902–909.e6.","ama":"Csata E, Perez-Escudero A, Laury E, et al. Fungal infection alters collective nutritional intake of ant colonies. Current Biology. 2024;34(4):902-909.e6. doi:10.1016/j.cub.2024.01.017","ieee":"E. Csata et al., “Fungal infection alters collective nutritional intake of ant colonies,” Current Biology, vol. 34, no. 4. Elsevier, p. 902–909.e6, 2024.","apa":"Csata, E., Perez-Escudero, A., Laury, E., Leitner, H., Latil, G., Heinze, J., … Dussutour, A. (2024). Fungal infection alters collective nutritional intake of ant colonies. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2024.01.017","chicago":"Csata, Eniko, Alfonso Perez-Escudero, Emmanuel Laury, Hanna Leitner, Gerard Latil, Juerge Heinze, Stephen Simpson, Sylvia Cremer, and Audrey Dussutour. “Fungal Infection Alters Collective Nutritional Intake of Ant Colonies.” Current Biology. Elsevier, 2024. https://doi.org/10.1016/j.cub.2024.01.017."},"article_type":"original","intvolume":" 34","date_updated":"2025-08-05T13:29:38Z","author":[{"first_name":"Eniko","last_name":"Csata","full_name":"Csata, Eniko"},{"full_name":"Perez-Escudero, Alfonso","last_name":"Perez-Escudero","first_name":"Alfonso"},{"last_name":"Laury","first_name":"Emmanuel","full_name":"Laury, Emmanuel"},{"id":"8fc5c6f6-5903-11ec-abad-c83f046253e7","full_name":"Leitner, Hanna","last_name":"Leitner","first_name":"Hanna"},{"full_name":"Latil, Gerard","first_name":"Gerard","last_name":"Latil"},{"first_name":"Juerge","last_name":"Heinze","full_name":"Heinze, Juerge"},{"last_name":"Simpson","first_name":"Stephen","full_name":"Simpson, Stephen"},{"last_name":"Cremer","orcid":"0000-0002-2193-3868","first_name":"Sylvia","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Dussutour, Audrey","last_name":"Dussutour","first_name":"Audrey"}],"pmid":1,"page":"902-909.e6","year":"2024","publication_status":"published","volume":34,"issue":"4","month":"02","date_published":"2024-02-26T00:00:00Z","_id":"14479","quality_controlled":"1","doi":"10.1016/j.cub.2024.01.017","isi":1,"acknowledgement":"We are sincerely grateful to the referees for their valuable comments and suggestions, which helped us to improve the paper. We are thankful to Jorgen Eilenberg and Nicolai V. Meyling for the fungal strain, to Simon Tragust, Abel Bernadou, and Brian Lazarro for insightful discussions, to Iago Sanmartín-Villar, Léa Briard, Céline Maitrel, and Nolwenn Rissen for their help with the experiments. Furthermore, we thank Anna V. Grasse for help with the immune gene expression analyses. We thank Sergio Ibarra for creating the graphical abstract. E.C. was supported by a Fyssen Foundation grant and the Alexander von Humboldt Foundation. A.D. was supported by the CNRS.","publisher":"Elsevier","article_processing_charge":"No","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Fungal infection alters collective nutritional intake of ant colonies","oa":1,"day":"26","department":[{"_id":"SyCr"}]},{"volume":132,"month":"04","year":"2024","file_date_updated":"2024-07-22T11:07:14Z","publication_status":"published","pmid":1,"page":"1148-1166","author":[{"full_name":"Rao, Pramod","first_name":"Pramod","last_name":"Rao"},{"last_name":"Mallikarjun","first_name":"B. R.","full_name":"Mallikarjun, B. R."},{"last_name":"Fox","first_name":"Gereon","full_name":"Fox, Gereon"},{"full_name":"Weyrich, Tim","first_name":"Tim","last_name":"Weyrich"},{"last_name":"Bickel","first_name":"Bernd","orcid":"0000-0001-6511-9385","id":"49876194-F248-11E8-B48F-1D18A9856A87","full_name":"Bickel, Bernd"},{"last_name":"Pfister","first_name":"Hanspeter","full_name":"Pfister, Hanspeter"},{"full_name":"Matusik, Wojciech","last_name":"Matusik","first_name":"Wojciech"},{"last_name":"Zhan","first_name":"Fangneng","full_name":"Zhan, Fangneng"},{"last_name":"Tewari","first_name":"Ayush","full_name":"Tewari, Ayush"},{"full_name":"Theobalt, Christian","first_name":"Christian","last_name":"Theobalt"},{"full_name":"Elgharib, Mohamed","last_name":"Elgharib","first_name":"Mohamed"}],"intvolume":" 132","ddc":["000"],"date_updated":"2025-08-05T13:28:58Z","language":[{"iso":"eng"}],"article_type":"original","citation":{"chicago":"Rao, Pramod, B. R. Mallikarjun, Gereon Fox, Tim Weyrich, Bernd Bickel, Hanspeter Pfister, Wojciech Matusik, et al. “A Deeper Analysis of Volumetric Relightiable Faces.” International Journal of Computer Vision. Springer Nature, 2024. https://doi.org/10.1007/s11263-023-01899-3.","apa":"Rao, P., Mallikarjun, B. R., Fox, G., Weyrich, T., Bickel, B., Pfister, H., … Elgharib, M. (2024). A deeper analysis of volumetric relightiable faces. International Journal of Computer Vision. Springer Nature. https://doi.org/10.1007/s11263-023-01899-3","ieee":"P. Rao et al., “A deeper analysis of volumetric relightiable faces,” International Journal of Computer Vision, vol. 132. Springer Nature, pp. 1148–1166, 2024.","ista":"Rao P, Mallikarjun BR, Fox G, Weyrich T, Bickel B, Pfister H, Matusik W, Zhan F, Tewari A, Theobalt C, Elgharib M. 2024. A deeper analysis of volumetric relightiable faces. International Journal of Computer Vision. 132, 1148–1166.","ama":"Rao P, Mallikarjun BR, Fox G, et al. A deeper analysis of volumetric relightiable faces. International Journal of Computer Vision. 2024;132:1148-1166. doi:10.1007/s11263-023-01899-3","mla":"Rao, Pramod, et al. “A Deeper Analysis of Volumetric Relightiable Faces.” International Journal of Computer Vision, vol. 132, Springer Nature, 2024, pp. 1148–66, doi:10.1007/s11263-023-01899-3.","short":"P. Rao, B.R. Mallikarjun, G. Fox, T. Weyrich, B. Bickel, H. Pfister, W. Matusik, F. Zhan, A. Tewari, C. Theobalt, M. Elgharib, International Journal of Computer Vision 132 (2024) 1148–1166."},"type":"journal_article","scopus_import":"1","publication":"International Journal of Computer Vision","date_created":"2023-11-05T23:00:54Z","oa_version":"Published Version","has_accepted_license":"1","status":"public","external_id":{"pmid":["38549787"],"isi":["001091935600002"]},"abstract":[{"text":"Portrait viewpoint and illumination editing is an important problem with several applications in VR/AR, movies, and photography. Comprehensive knowledge of geometry and illumination is critical for obtaining photorealistic results. Current methods are unable to explicitly model in 3D while handling both viewpoint and illumination editing from a single image. In this paper, we propose VoRF, a novel approach that can take even a single portrait image as input and relight human heads under novel illuminations that can be viewed from arbitrary viewpoints. VoRF represents a human head as a continuous volumetric field and learns a prior model of human heads using a coordinate-based MLP with individual latent spaces for identity and illumination. The prior model is learned in an auto-decoder manner over a diverse class of head shapes and appearances, allowing VoRF to generalize to novel test identities from a single input image. Additionally, VoRF has a reflectance MLP that uses the intermediate features of the prior model for rendering One-Light-at-A-Time (OLAT) images under novel views. We synthesize novel illuminations by combining these OLAT images with target environment maps. Qualitative and quantitative evaluations demonstrate the effectiveness of VoRF for relighting and novel view synthesis, even when applied to unseen subjects under uncontrolled illumination. This work is an extension of Rao et al. (VoRF: Volumetric Relightable Faces 2022). We provide extensive evaluation and ablative studies of our model and also provide an application, where any face can be relighted using textual input.","lang":"eng"}],"day":"01","department":[{"_id":"BeBi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"A deeper analysis of volumetric relightiable faces","oa":1,"article_processing_charge":"Yes (via OA deal)","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["1573-1405"],"issn":["0920-5691"]},"acknowledgement":"Open Access funding enabled and organized by Projekt DEAL.","file":[{"file_name":"2024_IJCV_Rao.pdf","file_id":"17304","date_updated":"2024-07-22T11:07:14Z","checksum":"5eef1d920f6fe700d7856098000d05f1","success":1,"file_size":9942520,"date_created":"2024-07-22T11:07:14Z","content_type":"application/pdf","access_level":"open_access","creator":"dernst","relation":"main_file"}],"isi":1,"doi":"10.1007/s11263-023-01899-3","publisher":"Springer Nature","_id":"14488","date_published":"2024-04-01T00:00:00Z","quality_controlled":"1"},{"month":"04","issue":"4","volume":147,"publication_status":"published","file_date_updated":"2024-07-16T08:22:13Z","year":"2024","page":"1436-1456","pmid":1,"author":[{"full_name":"Kaiyrzhanov, Rauan","first_name":"Rauan","last_name":"Kaiyrzhanov"},{"full_name":"Rad, Aboulfazl","last_name":"Rad","first_name":"Aboulfazl"},{"last_name":"Lin","first_name":"Sheng-Jia","full_name":"Lin, Sheng-Jia"},{"first_name":"Aida","last_name":"Bertoli-Avella","full_name":"Bertoli-Avella, Aida"},{"full_name":"Kallemeijn, Wouter 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147","citation":{"ista":"Kaiyrzhanov R, Rad A, Lin S-J, Bertoli-Avella A, Kallemeijn WW, Godwin A, Zaki MS, Huang K, Lau T, Petree C, Efthymiou S, Ghayoor Karimiani E, Hempel M, Normand EA, Rudnik-Schöneborn S, Schatz UA, Baggelaar MP, Ilyas M, Sultan T, Alvi JR, Ganieva M, Fowler B, Aanicai R, Akay Tayfun G, Al Saman A, Alswaid A, Amiri N, Asilova N, Shotelersuk V, Yeetong P, Azam M, Babaei M, Bahrami Monajemi G, Mohammadi P, Samie S, Banu SH, Basto JP, Kortüm F, Bauer M, Bauer P, Beetz C, Garshasbi M, Hameed Issa A, Eyaid W, Ahmed H, Hashemi N, Hassanpour K, Herman I, Ibrohimov S, Abdul-Majeed BA, Imdad M, Isrofilov M, Kaiyal Q, Khan S, Kirmse B, Koster J, Lourenço CM, Mitani T, Moldovan O, Murphy D, Najafi M, Pehlivan D, Rocha ME, Salpietro V, Schmidts M, Shalata A, Mahroum M, Talbeya JK, Taylor RW, Vazquez D, Vetro A, Waterham HR, Zaman M, Schrader TA, Chung WK, Guerrini R, Lupski JR, Gleeson J, Suri M, Jamshidi Y, Bhatia KP, Vona B, Schrader M, Severino M, Guille M, Tate EW, Varshney GK, Houlden H, Maroofian R. 2024. Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. Brain. 147(4), 1436–1456.","ieee":"R. Kaiyrzhanov et al., “Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders,” Brain, vol. 147, no. 4. Oxford University Press, pp. 1436–1456, 2024.","ama":"Kaiyrzhanov R, Rad A, Lin S-J, et al. Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. Brain. 2024;147(4):1436-1456. doi:10.1093/brain/awad380","apa":"Kaiyrzhanov, R., Rad, A., Lin, S.-J., Bertoli-Avella, A., Kallemeijn, W. W., Godwin, A., … Maroofian, R. (2024). Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. Brain. Oxford University Press. https://doi.org/10.1093/brain/awad380","short":"R. Kaiyrzhanov, A. Rad, S.-J. Lin, A. Bertoli-Avella, W.W. Kallemeijn, A. Godwin, M.S. Zaki, K. Huang, T. Lau, C. Petree, S. Efthymiou, E. Ghayoor Karimiani, M. Hempel, E.A. Normand, S. Rudnik-Schöneborn, U.A. Schatz, M.P. Baggelaar, M. Ilyas, T. Sultan, J.R. Alvi, M. Ganieva, B. Fowler, R. Aanicai, G. Akay Tayfun, A. Al Saman, A. Alswaid, N. Amiri, N. Asilova, V. Shotelersuk, P. Yeetong, M. Azam, M. Babaei, G. Bahrami Monajemi, P. Mohammadi, S. Samie, S.H. Banu, J.P. Basto, F. Kortüm, M. Bauer, P. Bauer, C. Beetz, M. Garshasbi, A. Hameed Issa, W. Eyaid, H. Ahmed, N. Hashemi, K. Hassanpour, I. Herman, S. Ibrohimov, B.A. Abdul-Majeed, M. Imdad, M. Isrofilov, Q. Kaiyal, S. Khan, B. Kirmse, J. Koster, C.M. Lourenço, T. Mitani, O. Moldovan, D. Murphy, M. Najafi, D. Pehlivan, M.E. Rocha, V. Salpietro, M. Schmidts, A. Shalata, M. Mahroum, J.K. Talbeya, R.W. Taylor, D. Vazquez, A. Vetro, H.R. Waterham, M. Zaman, T.A. Schrader, W.K. Chung, R. Guerrini, J.R. Lupski, J. Gleeson, M. Suri, Y. Jamshidi, K.P. Bhatia, B. Vona, M. Schrader, M. Severino, M. Guille, E.W. Tate, G.K. Varshney, H. Houlden, R. Maroofian, Brain 147 (2024) 1436–1456.","mla":"Kaiyrzhanov, Rauan, et al. “Bi-Allelic ACBD6 Variants Lead to a Neurodevelopmental Syndrome with Progressive and Complex Movement Disorders.” Brain, vol. 147, no. 4, Oxford University Press, 2024, pp. 1436–56, doi:10.1093/brain/awad380.","chicago":"Kaiyrzhanov, Rauan, Aboulfazl Rad, Sheng-Jia Lin, Aida Bertoli-Avella, Wouter W Kallemeijn, Annie Godwin, Maha S Zaki, et al. “Bi-Allelic ACBD6 Variants Lead to a Neurodevelopmental Syndrome with Progressive and Complex Movement Disorders.” Brain. Oxford University Press, 2024. https://doi.org/10.1093/brain/awad380."},"article_type":"original","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed, plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function in cells is still unclear, as is the consequence of ACBD6 defects on human pathophysiology. Utilizing exome sequencing and extensive international data sharing efforts, we identified 45 affected individuals from 28 unrelated families (consanguinity 93%) with bi-allelic pathogenic, predominantly loss-of-function (18/20) variants in ACBD6. We generated zebrafish and Xenopus tropicalis acbd6 knockouts by CRISPR/Cas9 and characterized the role of ACBD6 on protein N-myristoylation with YnMyr chemical proteomics in the model organisms and human cells, with the latter also being subjected further to ACBD6 peroxisomal localization studies. The affected individuals (23 males and 22 females), with ages ranging from 1 to 50 years old, typically present with a complex and progressive disease involving moderate-to-severe global developmental delay/intellectual disability (100%) with significant expressive language impairment (98%), movement disorders (97%), facial dysmorphism (95%), and mild cerebellar ataxia (85%) associated with gait impairment (94%), limb spasticity/hypertonia (76%), oculomotor (71%) and behavioural abnormalities (65%), overweight (59%), microcephaly (39%) and epilepsy (33%). The most conspicuous and common movement disorder was dystonia (94%), frequently leading to early-onset progressive postural deformities (97%), limb dystonia (55%), and cervical dystonia (31%). A jerky tremor in the upper limbs (63%), a mild head tremor (59%), parkinsonism/hypokinesia developing with advancing age (32%), and simple motor and vocal tics were among other frequent movement disorders. Midline brain malformations including corpus callosum abnormalities (70%), hypoplasia/agenesis of the anterior commissure (66%), short midbrain and small inferior cerebellar vermis (38% each), as well as hypertrophy of the clava (24%) were common neuroimaging findings. acbd6-deficient zebrafish and Xenopus models effectively recapitulated many clinical phenotypes reported in patients including movement disorders, progressive neuromotor impairment, seizures, microcephaly, craniofacial dysmorphism, and midbrain defects accompanied by developmental delay with increased mortality over time. Unlike ACBD5, ACBD6 did not show a peroxisomal localisation and ACBD6-deficiency was not associated with altered peroxisomal parameters in patient fibroblasts. Significant differences in YnMyr-labelling were observed for 68 co- and 18 post-translationally N-myristoylated proteins in patient-derived fibroblasts. N-Myristoylation was similarly affected in acbd6-deficient zebrafish and Xenopus tropicalis models, including Fus, Marcks, and Chchd-related proteins implicated in neurological diseases. The present study provides evidence that bi-allelic pathogenic variants in ACBD6 lead to a distinct neurodevelopmental syndrome accompanied by complex and progressive cognitive and movement disorders."}],"external_id":{"pmid":["37951597"]},"status":"public","has_accepted_license":"1","oa_version":"Submitted Version","date_created":"2023-11-16T12:36:51Z","scopus_import":"1","publication":"Brain","type":"journal_article","department":[{"_id":"GradSch"}],"keyword":["Neurology (clinical)"],"day":"01","oa":1,"title":"Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1460-2156"],"issn":["0006-8950"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"No","publisher":"Oxford University Press","file":[{"file_size":2641456,"file_id":"17254","file_name":"2024_Brain_Kaiyrzhanov.pdf","date_updated":"2024-07-16T08:22:13Z","checksum":"0ee7a8ab9300225d60968f7a3e3cfa0d","success":1,"access_level":"open_access","creator":"dernst","relation":"main_file","content_type":"application/pdf","date_created":"2024-07-16T08:22:13Z"}],"doi":"10.1093/brain/awad380","extern":"1","quality_controlled":"1","_id":"14543","date_published":"2024-04-01T00:00:00Z"}]