[{"date_updated":"2025-09-04T11:29:46Z","intvolume":"       674","status":"public","external_id":{"isi":["001127429000001"]},"abstract":[{"text":"In order to demonstrate the stability of newly proposed iridium-based Ir2Cr(In,Sn) and IrRhCr(In,Sn) heusler alloys, we present ab-initio analysis of these alloys by examining various properties to prove their stability. The stability of these alloys can be inferred from different cohesive and formation energies as well as positive phonon frequencies. Their electronic structure results indicate that they are semi-metals in nature. The magnetic moments are computed using the Slater-Pauling formula and exhibit a high value, with the Cr atom contributing the most in all alloys. Mulliken’s charge analysis results show that our alloys contain a range of linkages, mainly ionic and covalent ones. The ductility and mechanical stability of these alloys are confirmed by elastic constants viz. Poisson’s ratio, Pugh’s ratio, and many different types of elastic moduli.","lang":"eng"}],"type":"journal_article","publication":"Physica B: Condensed Matter","scopus_import":"1","date_created":"2023-12-10T23:00:56Z","oa_version":"None","language":[{"iso":"eng"}],"citation":{"mla":"Gupta, Shyam Lal, et al. “Ab-Initio Stability of Iridium Based Newly Proposed Full and Quaternary Heusler Alloys.” <i>Physica B: Condensed Matter</i>, vol. 674, no. 2, 415539, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.physb.2023.415539\">10.1016/j.physb.2023.415539</a>.","short":"S.L. Gupta, S. Singh, S. Kumar, U. Anupam, S.S. Thakur, A. Kumar, S. Panwar, D. Diwaker, Physica B: Condensed Matter 674 (2024).","apa":"Gupta, S. L., Singh, S., Kumar, S., Anupam, U., Thakur, S. S., Kumar, A., … Diwaker, D. (2024). Ab-initio stability of Iridium based newly proposed full and quaternary heusler alloys. <i>Physica B: Condensed Matter</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.physb.2023.415539\">https://doi.org/10.1016/j.physb.2023.415539</a>","ama":"Gupta SL, Singh S, Kumar S, et al. Ab-initio stability of Iridium based newly proposed full and quaternary heusler alloys. <i>Physica B: Condensed Matter</i>. 2024;674(2). doi:<a href=\"https://doi.org/10.1016/j.physb.2023.415539\">10.1016/j.physb.2023.415539</a>","ista":"Gupta SL, Singh S, Kumar S, Anupam U, Thakur SS, Kumar A, Panwar S, Diwaker D. 2024. Ab-initio stability of Iridium based newly proposed full and quaternary heusler alloys. Physica B: Condensed Matter. 674(2), 415539.","ieee":"S. L. Gupta <i>et al.</i>, “Ab-initio stability of Iridium based newly proposed full and quaternary heusler alloys,” <i>Physica B: Condensed Matter</i>, vol. 674, no. 2. Elsevier, 2024.","chicago":"Gupta, Shyam Lal, Saurabh Singh, Sumit Kumar, Unknown Anupam, Samjeet Singh Thakur, Ashish Kumar, Sanjay Panwar, and D. Diwaker. “Ab-Initio Stability of Iridium Based Newly Proposed Full and Quaternary Heusler Alloys.” <i>Physica B: Condensed Matter</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.physb.2023.415539\">https://doi.org/10.1016/j.physb.2023.415539</a>."},"article_type":"original","publication_status":"published","year":"2024","month":"02","volume":674,"issue":"2","author":[{"last_name":"Gupta","first_name":"Shyam Lal","full_name":"Gupta, Shyam Lal"},{"full_name":"Singh, Saurabh","id":"12d625da-9cb3-11ed-9667-af09d37d3f0a","last_name":"Singh","orcid":"0000-0003-2209-5269","first_name":"Saurabh"},{"first_name":"Sumit","last_name":"Kumar","full_name":"Kumar, Sumit"},{"full_name":"Anupam, Unknown","first_name":"Unknown","last_name":"Anupam"},{"full_name":"Thakur, Samjeet Singh","first_name":"Samjeet Singh","last_name":"Thakur"},{"last_name":"Kumar","first_name":"Ashish","full_name":"Kumar, Ashish"},{"full_name":"Panwar, Sanjay","first_name":"Sanjay","last_name":"Panwar"},{"full_name":"Diwaker, D.","first_name":"D.","last_name":"Diwaker"}],"publisher":"Elsevier","doi":"10.1016/j.physb.2023.415539","isi":1,"article_number":"415539","_id":"14652","date_published":"2024-02-01T00:00:00Z","quality_controlled":"1","title":"Ab-initio stability of Iridium based newly proposed full and quaternary heusler alloys","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"MaIb"}],"day":"01","publication_identifier":{"issn":["0921-4526"]},"article_processing_charge":"No"},{"language":[{"iso":"eng"}],"citation":{"chicago":"Kluibenschedl, Florian, Anna Ploner, Christina Meisenbichler, Robert Konrat, and Thomas Müller. “Advanced Motion Tracking for Interactive Mass Spectrometry Imaging (IMSI).” <i>International Journal of Mass Spectrometry</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">https://doi.org/10.1016/j.ijms.2023.117168</a>.","apa":"Kluibenschedl, F., Ploner, A., Meisenbichler, C., Konrat, R., &#38; Müller, T. (2024). Advanced motion tracking for interactive mass spectrometry imaging (IMSI). <i>International Journal of Mass Spectrometry</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">https://doi.org/10.1016/j.ijms.2023.117168</a>","ieee":"F. Kluibenschedl, A. Ploner, C. Meisenbichler, R. Konrat, and T. Müller, “Advanced motion tracking for interactive mass spectrometry imaging (IMSI),” <i>International Journal of Mass Spectrometry</i>, vol. 495. Elsevier, 2024.","ista":"Kluibenschedl F, Ploner A, Meisenbichler C, Konrat R, Müller T. 2024. Advanced motion tracking for interactive mass spectrometry imaging (IMSI). International Journal of Mass Spectrometry. 495, 117168.","ama":"Kluibenschedl F, Ploner A, Meisenbichler C, Konrat R, Müller T. Advanced motion tracking for interactive mass spectrometry imaging (IMSI). <i>International Journal of Mass Spectrometry</i>. 2024;495. doi:<a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">10.1016/j.ijms.2023.117168</a>","mla":"Kluibenschedl, Florian, et al. “Advanced Motion Tracking for Interactive Mass Spectrometry Imaging (IMSI).” <i>International Journal of Mass Spectrometry</i>, vol. 495, 117168, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.ijms.2023.117168\">10.1016/j.ijms.2023.117168</a>.","short":"F. Kluibenschedl, A. Ploner, C. Meisenbichler, R. Konrat, T. Müller, International Journal of Mass Spectrometry 495 (2024)."},"article_type":"original","type":"journal_article","oa_version":"Published Version","date_created":"2023-12-10T23:00:57Z","scopus_import":"1","publication":"International Journal of Mass Spectrometry","external_id":{"isi":["001125054400001"]},"has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"Mass spectrometry imaging (MSI) is a powerful analytical technique for the two-dimensional (2D) localization of chemicals on surfaces. Conventional MSI experiments require to predefine the surface of interest based on photographic or microscopic images. Typically, these boundaries can no longer be changed or adjusted once the experiment has been started. In terms of a more interactive approach we recently developed a pen-like ionization interface which is directly connected to the mass spectrometer. The device allows the user to ionize chemicals by desorption electrospray ionization (DESI) and to freely move the interface over a surface of interest. A mini camera, which is mounted on the tip of the pen, magnifies the desorption area and enables a simple positioning of the pen. The combination of optical data from the camera module and chemical data obtained by mass analysis facilitates a novel type of imaging experiment: interactive mass spectrometry imaging (IMSI). For this application, we present a novel approach for a robust, optical flow-based motion detection. While the live video stream from the camera is used to track the pen's motion across the surface a post-acquisition algorithm correlates the coordinates of the pen trajectory with respective mass spectra obtained from a simultaneous mass spectrometric data acquisition. This algorithm is no longer dependent on a single, manually applied optical marker on the sample surface, which has to be visible on all video frames throughout the analysis. The advanced DESI-IMSI method was successfully tested on inkjet-printed letters as well as mouse brain tissue samples. Validation of the results was done by comparing DESI-IMSI with standard DESI-MSI data."}],"intvolume":"       495","ddc":["540"],"date_updated":"2025-09-04T11:30:59Z","author":[{"full_name":"Kluibenschedl, Florian","id":"7499e70e-eb2c-11ec-b98b-f925648bc9d9","first_name":"Florian","last_name":"Kluibenschedl"},{"full_name":"Ploner, Anna","first_name":"Anna","last_name":"Ploner"},{"last_name":"Meisenbichler","first_name":"Christina","full_name":"Meisenbichler, Christina"},{"first_name":"Robert","last_name":"Konrat","full_name":"Konrat, Robert"},{"full_name":"Müller, Thomas","first_name":"Thomas","last_name":"Müller"}],"volume":495,"month":"01","year":"2024","file_date_updated":"2024-07-16T08:27:34Z","publication_status":"published","date_published":"2024-01-01T00:00:00Z","_id":"14653","quality_controlled":"1","article_number":"117168","isi":1,"doi":"10.1016/j.ijms.2023.117168","acknowledgement":"We would like to thank Marco Sealey Cardona, PhD for help with the mouse brain samples and acknowledge the financial support by 1669 Förderkreis of the University of Innsbruck, Austria Wirtschaftsservice (AWS), D. Swarovski KG and Tyrolean Science Fund (TWF).","file":[{"access_level":"open_access","relation":"main_file","creator":"dernst","content_type":"application/pdf","date_created":"2024-07-16T08:27:34Z","file_size":3003139,"date_updated":"2024-07-16T08:27:34Z","file_id":"17256","file_name":"2024_IJMS_Kluibenschedl.pdf","success":1,"checksum":"6c5eb6dc07af70a59251d2c6fed38894"}],"publisher":"Elsevier","article_processing_charge":"Yes (in subscription journal)","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["1387-3806"]},"day":"01","department":[{"_id":"GradSch"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Advanced motion tracking for interactive mass spectrometry imaging (IMSI)","oa":1},{"date_published":"2024-02-01T00:00:00Z","_id":"14660","quality_controlled":"1","publisher":"London Mathematical Society","isi":1,"acknowledgement":"M.N. was supported by the János Bolyai Scholarship of the Hungarian Academy of Sciences aswell as the National Research, Development and Innovation Fund (NRDI) grants K119670 andK131529, and the ÚNKP-22-5 New National Excellence Program of the Ministry for Innovationand Technology from the source of the NRDI as well as the ELTE TKP 2021-NKTA-62 fundingscheme","doi":"10.1112/blms.12965","file":[{"success":1,"checksum":"30ea0694757bc668cf7cd15ae357b35e","date_updated":"2024-07-16T10:35:10Z","file_id":"17259","file_name":"2024_BulletinLondonMathSoc_Ivanov.pdf","file_size":111756,"date_created":"2024-07-16T10:35:10Z","content_type":"application/pdf","relation":"main_file","creator":"dernst","access_level":"open_access"}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["0024-6093"],"eissn":["1469-2120"]},"article_processing_charge":"Yes (via OA deal)","title":"Quantitative Steinitz theorem: A polynomial bound","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"UlWa"}],"day":"01","has_accepted_license":"1","status":"public","external_id":{"isi":["001113277100001"],"arxiv":["2212.04308"]},"abstract":[{"text":"The classical Steinitz theorem states that if the origin belongs to the interior of the convex hull of a set 𝑆⊂ℝ𝑑, then there are at most 2𝑑 points of 𝑆 whose convex hull contains the origin in the interior. Bárány, Katchalski,and Pach proved the following quantitative version of Steinitz’s theorem. Let 𝑄 be a convex polytope in ℝ𝑑 containing the standard Euclidean unit ball 𝐁𝑑. Then there exist at most 2𝑑 vertices of 𝑄 whose convex hull 𝑄′ satisfies 𝑟𝐁𝑑⊂𝑄′ with 𝑟⩾𝑑−2𝑑. They conjectured that 𝑟⩾𝑐𝑑−1∕2 holds with a universal constant 𝑐>0. We prove 𝑟⩾15𝑑2, the first polynomial lower bound on 𝑟. Furthermore, we show that 𝑟 is not greater than 2/√𝑑.","lang":"eng"}],"type":"journal_article","corr_author":"1","oa_version":"Published Version","scopus_import":"1","publication":"Bulletin of the London Mathematical Society","date_created":"2023-12-10T23:00:58Z","language":[{"iso":"eng"}],"article_type":"original","citation":{"ama":"Ivanov G, Naszódi M. Quantitative Steinitz theorem: A polynomial bound. <i>Bulletin of the London Mathematical Society</i>. 2024;56(2):796-802. doi:<a href=\"https://doi.org/10.1112/blms.12965\">10.1112/blms.12965</a>","ista":"Ivanov G, Naszódi M. 2024. Quantitative Steinitz theorem: A polynomial bound. Bulletin of the London Mathematical Society. 56(2), 796–802.","ieee":"G. Ivanov and M. Naszódi, “Quantitative Steinitz theorem: A polynomial bound,” <i>Bulletin of the London Mathematical Society</i>, vol. 56, no. 2. London Mathematical Society, pp. 796–802, 2024.","apa":"Ivanov, G., &#38; Naszódi, M. (2024). Quantitative Steinitz theorem: A polynomial bound. <i>Bulletin of the London Mathematical Society</i>. London Mathematical Society. <a href=\"https://doi.org/10.1112/blms.12965\">https://doi.org/10.1112/blms.12965</a>","short":"G. Ivanov, M. Naszódi, Bulletin of the London Mathematical Society 56 (2024) 796–802.","mla":"Ivanov, Grigory, and Márton Naszódi. “Quantitative Steinitz Theorem: A Polynomial Bound.” <i>Bulletin of the London Mathematical Society</i>, vol. 56, no. 2, London Mathematical Society, 2024, pp. 796–802, doi:<a href=\"https://doi.org/10.1112/blms.12965\">10.1112/blms.12965</a>.","chicago":"Ivanov, Grigory, and Márton Naszódi. “Quantitative Steinitz Theorem: A Polynomial Bound.” <i>Bulletin of the London Mathematical Society</i>. London Mathematical Society, 2024. <a href=\"https://doi.org/10.1112/blms.12965\">https://doi.org/10.1112/blms.12965</a>."},"arxiv":1,"ddc":["510"],"date_updated":"2025-09-04T11:31:49Z","intvolume":"        56","author":[{"full_name":"Ivanov, Grigory","id":"87744F66-5C6F-11EA-AFE0-D16B3DDC885E","last_name":"Ivanov","first_name":"Grigory"},{"last_name":"Naszódi","first_name":"Márton","full_name":"Naszódi, Márton"}],"page":"796-802","publication_status":"published","file_date_updated":"2024-07-16T10:35:10Z","year":"2024","month":"02","volume":56,"issue":"2"},{"publisher":"IEEE","acknowledgement":"The work of Yihan Zhang was supported by the European Union’s Horizon 2020 Research and Innovation Programme under Grant 682203-ERC-[Inf-Speed-Tradeoff]. The work of Shashank Vatedka was supported in part by the Core Research Grant from the Science and\r\nEngineering Research Board, India, under Grant CRG/2022/004464; and in\r\npart by the Department of Science and Technology (DST), India, under Grant\r\nDST/INT/RUS/RSF/P-41/2020 (TPN No. 65025).","isi":1,"doi":"10.1109/TIT.2023.3334032","_id":"14665","quality_controlled":"1","date_published":"2024-02-01T00:00:00Z","title":"Multiple packing: Lower bounds via error exponents","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"MaMo"}],"day":"01","publication_identifier":{"eissn":["1557-9654"],"issn":["0018-9448"]},"article_processing_charge":"No","arxiv":1,"date_updated":"2025-09-04T11:32:49Z","intvolume":"        70","status":"public","external_id":{"isi":["001166812100008"],"arxiv":["2211.04408"]},"abstract":[{"text":"We derive lower bounds on the maximal rates for multiple packings in high-dimensional Euclidean spaces. For any N > 0 and L ∈ Z ≥2 , a multiple packing is a set C of points in R n such that any point in R n lies in the intersection of at most L - 1 balls of radius √ nN around points in C . This is a natural generalization of the sphere packing problem. We study the multiple packing problem for both bounded point sets whose points have norm at most √ nP for some constant P > 0, and unbounded point sets whose points are allowed to be anywhere in R n . Given a well-known connection with coding theory, multiple packings can be viewed as the Euclidean analog of list-decodable codes, which are well-studied over finite fields. We derive the best known lower bounds on the optimal multiple packing density. This is accomplished by establishing an inequality which relates the list-decoding error exponent for additive white Gaussian noise channels, a quantity of average-case nature, to the list-decoding radius, a quantity of worst-case nature. We also derive novel bounds on the list-decoding error exponent for infinite constellations and closed-form expressions for the list-decoding error exponents for the power-constrained AWGN channel, which may be of independent interest beyond multiple packing.","lang":"eng"}],"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2211.04408","open_access":"1"}],"corr_author":"1","type":"journal_article","publication":"IEEE Transactions on Information Theory","scopus_import":"1","oa_version":"Preprint","date_created":"2023-12-10T23:01:00Z","language":[{"iso":"eng"}],"citation":{"chicago":"Zhang, Yihan, and Shashank Vatedka. “Multiple Packing: Lower Bounds via Error Exponents.” <i>IEEE Transactions on Information Theory</i>. IEEE, 2024. <a href=\"https://doi.org/10.1109/TIT.2023.3334032\">https://doi.org/10.1109/TIT.2023.3334032</a>.","apa":"Zhang, Y., &#38; Vatedka, S. (2024). Multiple packing: Lower bounds via error exponents. <i>IEEE Transactions on Information Theory</i>. IEEE. <a href=\"https://doi.org/10.1109/TIT.2023.3334032\">https://doi.org/10.1109/TIT.2023.3334032</a>","ama":"Zhang Y, Vatedka S. Multiple packing: Lower bounds via error exponents. <i>IEEE Transactions on Information Theory</i>. 2024;70(2):1008-1039. doi:<a href=\"https://doi.org/10.1109/TIT.2023.3334032\">10.1109/TIT.2023.3334032</a>","ista":"Zhang Y, Vatedka S. 2024. Multiple packing: Lower bounds via error exponents. IEEE Transactions on Information Theory. 70(2), 1008–1039.","ieee":"Y. Zhang and S. Vatedka, “Multiple packing: Lower bounds via error exponents,” <i>IEEE Transactions on Information Theory</i>, vol. 70, no. 2. IEEE, pp. 1008–1039, 2024.","mla":"Zhang, Yihan, and Shashank Vatedka. “Multiple Packing: Lower Bounds via Error Exponents.” <i>IEEE Transactions on Information Theory</i>, vol. 70, no. 2, IEEE, 2024, pp. 1008–39, doi:<a href=\"https://doi.org/10.1109/TIT.2023.3334032\">10.1109/TIT.2023.3334032</a>.","short":"Y. Zhang, S. Vatedka, IEEE Transactions on Information Theory 70 (2024) 1008–1039."},"article_type":"original","publication_status":"published","year":"2024","month":"02","volume":70,"issue":"2","author":[{"id":"2ce5da42-b2ea-11eb-bba5-9f264e9d002c","full_name":"Zhang, Yihan","last_name":"Zhang","first_name":"Yihan","orcid":"0000-0002-6465-6258"},{"first_name":"Shashank","last_name":"Vatedka","full_name":"Vatedka, Shashank"}],"page":"1008-1039"},{"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["2666-1667"]},"article_processing_charge":"Yes (in subscription journal)","department":[{"_id":"SiHi"}],"day":"15","keyword":["General Immunology and Microbiology","General Biochemistry","Genetics and Molecular Biology","General Neuroscience"],"title":"Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_number":"102771","date_published":"2024-03-15T00:00:00Z","_id":"14683","quality_controlled":"1","publisher":"Elsevier","doi":"10.1016/j.xpro.2023.102771","file":[{"access_level":"open_access","relation":"main_file","creator":"dernst","date_created":"2024-07-16T11:50:03Z","content_type":"application/pdf","file_size":8871807,"date_updated":"2024-07-16T11:50:03Z","file_id":"17260","file_name":"2024_STARProtoc_Amberg.pdf","checksum":"3f0ee62e04bf5a44b45b035662826e95","success":1}],"acknowledgement":"This research was supported by the Scientific Service Units (SSU) at IST Austria through resources provided by the Imaging & Optics Facility (IOF) and Preclinical Facilities (PCF). N.A. received support from FWF Firnberg-Programme (T 1031). G.C. received support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 754411 as an ISTplus postdoctoral fellow. This work was also supported by IST Austria institutional funds, FWF SFB F78 to S.H., and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 725780 LinPro) to S.H.","pmid":1,"author":[{"id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","full_name":"Amberg, Nicole","last_name":"Amberg","first_name":"Nicole","orcid":"0000-0002-3183-8207"},{"full_name":"Cheung, Giselle T","id":"471195F6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8457-2572","first_name":"Giselle T","last_name":"Cheung"},{"last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","first_name":"Simon","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"month":"03","volume":5,"issue":"1","file_date_updated":"2024-07-16T11:50:03Z","publication_status":"published","year":"2024","language":[{"iso":"eng"}],"citation":{"mla":"Amberg, Nicole, et al. “Protocol for Sorting Cells from Mouse Brains Labeled with Mosaic Analysis with Double Markers by Flow Cytometry.” <i>STAR Protocols</i>, vol. 5, no. 1, 102771, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102771\">10.1016/j.xpro.2023.102771</a>.","short":"N. Amberg, G.T. Cheung, S. Hippenmeyer, STAR Protocols 5 (2024).","apa":"Amberg, N., Cheung, G. T., &#38; Hippenmeyer, S. (2024). Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry. <i>STAR Protocols</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xpro.2023.102771\">https://doi.org/10.1016/j.xpro.2023.102771</a>","ista":"Amberg N, Cheung GT, Hippenmeyer S. 2024. Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry. STAR Protocols. 5(1), 102771.","ama":"Amberg N, Cheung GT, Hippenmeyer S. Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry. <i>STAR Protocols</i>. 2024;5(1). doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102771\">10.1016/j.xpro.2023.102771</a>","ieee":"N. Amberg, G. T. Cheung, and S. Hippenmeyer, “Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry,” <i>STAR Protocols</i>, vol. 5, no. 1. Elsevier, 2024.","chicago":"Amberg, Nicole, Giselle T Cheung, and Simon Hippenmeyer. “Protocol for Sorting Cells from Mouse Brains Labeled with Mosaic Analysis with Double Markers by Flow Cytometry.” <i>STAR Protocols</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.xpro.2023.102771\">https://doi.org/10.1016/j.xpro.2023.102771</a>."},"article_type":"review","ec_funded":1,"external_id":{"pmid":["38070137"]},"status":"public","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Mosaic analysis with double markers (MADM) technology enables the generation of genetic mosaic tissue in mice and high-resolution phenotyping at the individual cell level. Here, we present a protocol for isolating MADM-labeled cells with high yield for downstream molecular analyses using fluorescence-activated cell sorting (FACS). We describe steps for generating MADM-labeled mice, perfusion, single-cell suspension, and debris removal. We then detail procedures for cell sorting by FACS and downstream analysis. This protocol is suitable for embryonic to adult mice.\r\nFor complete details on the use and execution of this protocol, please refer to Contreras et al. (2021).1"}],"type":"journal_article","corr_author":"1","publication":"STAR Protocols","scopus_import":"1","date_created":"2023-12-13T11:48:05Z","oa_version":"Published Version","project":[{"grant_number":"T01031","call_identifier":"FWF","name":"Role of Eed in neural stem cell lineage progression","_id":"268F8446-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411"},{"grant_number":"F7805","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression","_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E"},{"grant_number":"725780","call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development"}],"ddc":["570"],"date_updated":"2025-04-15T08:23:06Z","intvolume":"         5"},{"title":"Towards practical metal–oxygen batteries: General discussion","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"StFr"}],"day":"29","keyword":["Physical and Theoretical Chemistry"],"publication_identifier":{"eissn":["1364-5498"],"issn":["1359-6640"]},"article_processing_charge":"No","publisher":"Royal Society of Chemistry","isi":1,"doi":"10.1039/d3fd90062b","_id":"14701","date_published":"2024-01-29T00:00:00Z","quality_controlled":"1","publication_status":"published","year":"2024","month":"01","volume":248,"author":[{"last_name":"Archer","first_name":"Lynden A.","full_name":"Archer, Lynden A."},{"full_name":"Bruce, Peter G.","first_name":"Peter G.","last_name":"Bruce"},{"last_name":"Calvo","first_name":"Ernesto J.","full_name":"Calvo, Ernesto J."},{"full_name":"Dewar, Daniel","last_name":"Dewar","first_name":"Daniel"},{"full_name":"Ellison, James H. J.","first_name":"James H. J.","last_name":"Ellison"},{"full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","orcid":"0000-0003-2902-5319","first_name":"Stefan Alexander","last_name":"Freunberger"},{"last_name":"Gao","first_name":"Xiangwen","full_name":"Gao, Xiangwen"},{"full_name":"Hardwick, Laurence J.","first_name":"Laurence J.","last_name":"Hardwick"},{"last_name":"Horwitz","first_name":"Gabriela","full_name":"Horwitz, Gabriela"},{"last_name":"Janek","first_name":"Jürgen","full_name":"Janek, Jürgen"},{"first_name":"Lee R.","last_name":"Johnson","full_name":"Johnson, Lee R."},{"full_name":"Jordan, Jack W.","last_name":"Jordan","first_name":"Jack W."},{"first_name":"Shoichi","last_name":"Matsuda","full_name":"Matsuda, Shoichi"},{"first_name":"Svetlana","last_name":"Menkin","full_name":"Menkin, Svetlana"},{"last_name":"Mondal","first_name":"Soumyadip","full_name":"Mondal, Soumyadip","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48"},{"first_name":"Qianyuan","last_name":"Qiu","full_name":"Qiu, Qianyuan"},{"last_name":"Samarakoon","first_name":"Thukshan","full_name":"Samarakoon, Thukshan"},{"full_name":"Temprano, Israel","first_name":"Israel","last_name":"Temprano"},{"full_name":"Uosaki, Kohei","last_name":"Uosaki","first_name":"Kohei"},{"full_name":"Vailaya, Ganesh","last_name":"Vailaya","first_name":"Ganesh"},{"last_name":"Wachsman","first_name":"Eric D.","full_name":"Wachsman, Eric D."},{"full_name":"Wu, Yiying","first_name":"Yiying","last_name":"Wu"},{"full_name":"Ye, Shen","last_name":"Ye","first_name":"Shen"}],"page":"392-411","pmid":1,"date_updated":"2025-09-04T11:34:30Z","intvolume":"       248","status":"public","external_id":{"pmid":["38112202"],"isi":["001130090400001"]},"type":"journal_article","oa_version":"None","publication":"Faraday Discussions","scopus_import":"1","date_created":"2023-12-20T10:48:09Z","language":[{"iso":"eng"}],"citation":{"chicago":"Archer, Lynden A., Peter G. Bruce, Ernesto J. Calvo, Daniel Dewar, James H. J. Ellison, Stefan Alexander Freunberger, Xiangwen Gao, et al. “Towards Practical Metal–Oxygen Batteries: General Discussion.” <i>Faraday Discussions</i>. Royal Society of Chemistry, 2024. <a href=\"https://doi.org/10.1039/d3fd90062b\">https://doi.org/10.1039/d3fd90062b</a>.","short":"L.A. Archer, P.G. Bruce, E.J. Calvo, D. Dewar, J.H.J. Ellison, S.A. Freunberger, X. Gao, L.J. Hardwick, G. Horwitz, J. Janek, L.R. Johnson, J.W. Jordan, S. Matsuda, S. Menkin, S. Mondal, Q. Qiu, T. Samarakoon, I. Temprano, K. Uosaki, G. Vailaya, E.D. Wachsman, Y. Wu, S. Ye, Faraday Discussions 248 (2024) 392–411.","mla":"Archer, Lynden A., et al. “Towards Practical Metal–Oxygen Batteries: General Discussion.” <i>Faraday Discussions</i>, vol. 248, Royal Society of Chemistry, 2024, pp. 392–411, doi:<a href=\"https://doi.org/10.1039/d3fd90062b\">10.1039/d3fd90062b</a>.","ieee":"L. A. Archer <i>et al.</i>, “Towards practical metal–oxygen batteries: General discussion,” <i>Faraday Discussions</i>, vol. 248. Royal Society of Chemistry, pp. 392–411, 2024.","ista":"Archer LA, Bruce PG, Calvo EJ, Dewar D, Ellison JHJ, Freunberger SA, Gao X, Hardwick LJ, Horwitz G, Janek J, Johnson LR, Jordan JW, Matsuda S, Menkin S, Mondal S, Qiu Q, Samarakoon T, Temprano I, Uosaki K, Vailaya G, Wachsman ED, Wu Y, Ye S. 2024. Towards practical metal–oxygen batteries: General discussion. Faraday Discussions. 248, 392–411.","ama":"Archer LA, Bruce PG, Calvo EJ, et al. Towards practical metal–oxygen batteries: General discussion. <i>Faraday Discussions</i>. 2024;248:392-411. doi:<a href=\"https://doi.org/10.1039/d3fd90062b\">10.1039/d3fd90062b</a>","apa":"Archer, L. A., Bruce, P. G., Calvo, E. J., Dewar, D., Ellison, J. H. J., Freunberger, S. A., … Ye, S. (2024). Towards practical metal–oxygen batteries: General discussion. <i>Faraday Discussions</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d3fd90062b\">https://doi.org/10.1039/d3fd90062b</a>"},"article_type":"letter_note"},{"article_processing_charge":"No","publication_identifier":{"eissn":["1364-5498"],"issn":["1359-6640"]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Materials for stable metal–oxygen battery cathodes: general discussion","day":"29","keyword":["Physical and Theoretical Chemistry"],"department":[{"_id":"StFr"}],"_id":"14702","date_published":"2024-01-29T00:00:00Z","quality_controlled":"1","isi":1,"doi":"10.1039/d3fd90059b","publisher":"Royal Society of Chemistry","author":[{"full_name":"Attard, Gary A.","last_name":"Attard","first_name":"Gary A."},{"full_name":"Calvo, Ernesto J.","first_name":"Ernesto J.","last_name":"Calvo"},{"full_name":"Curtiss, Larry A.","last_name":"Curtiss","first_name":"Larry A."},{"last_name":"Dewar","first_name":"Daniel","full_name":"Dewar, Daniel"},{"last_name":"Ellison","first_name":"James H. J.","full_name":"Ellison, James H. J."},{"full_name":"Gao, Xiangwen","first_name":"Xiangwen","last_name":"Gao"},{"first_name":"Clare P.","last_name":"Grey","full_name":"Grey, Clare P."},{"last_name":"Hardwick","first_name":"Laurence J.","full_name":"Hardwick, Laurence J."},{"first_name":"Gabriela","last_name":"Horwitz","full_name":"Horwitz, Gabriela"},{"last_name":"Janek","first_name":"Juergen","full_name":"Janek, Juergen"},{"first_name":"Lee R.","last_name":"Johnson","full_name":"Johnson, Lee R."},{"full_name":"Jordan, Jack W.","last_name":"Jordan","first_name":"Jack W."},{"last_name":"Matsuda","first_name":"Shoichi","full_name":"Matsuda, Shoichi"},{"last_name":"Mondal","first_name":"Soumyadip","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48","full_name":"Mondal, Soumyadip"},{"full_name":"Neale, Alex R.","last_name":"Neale","first_name":"Alex R."},{"first_name":"Nagore","last_name":"Ortiz-Vitoriano","full_name":"Ortiz-Vitoriano, Nagore"},{"full_name":"Temprano, Israel","last_name":"Temprano","first_name":"Israel"},{"first_name":"Ganesh","last_name":"Vailaya","full_name":"Vailaya, Ganesh"},{"first_name":"Eric D.","last_name":"Wachsman","full_name":"Wachsman, Eric D."},{"last_name":"Wang","first_name":"Hsien-Hau","full_name":"Wang, Hsien-Hau"},{"last_name":"Wu","first_name":"Yiying","full_name":"Wu, Yiying"},{"full_name":"Ye, Shen","last_name":"Ye","first_name":"Shen"}],"pmid":1,"page":"75-88","year":"2024","publication_status":"published","volume":248,"month":"01","type":"journal_article","scopus_import":"1","publication":"Faraday Discussions","date_created":"2023-12-20T10:49:43Z","oa_version":"None","status":"public","external_id":{"pmid":["38109098"],"isi":["001130029600001"]},"language":[{"iso":"eng"}],"citation":{"chicago":"Attard, Gary A., Ernesto J. Calvo, Larry A. Curtiss, Daniel Dewar, James H. J. Ellison, Xiangwen Gao, Clare P. Grey, et al. “Materials for Stable Metal–Oxygen Battery Cathodes: General Discussion.” <i>Faraday Discussions</i>. Royal Society of Chemistry, 2024. <a href=\"https://doi.org/10.1039/d3fd90059b\">https://doi.org/10.1039/d3fd90059b</a>.","ieee":"G. A. Attard <i>et al.</i>, “Materials for stable metal–oxygen battery cathodes: general discussion,” <i>Faraday Discussions</i>, vol. 248. Royal Society of Chemistry, pp. 75–88, 2024.","ista":"Attard GA, Calvo EJ, Curtiss LA, Dewar D, Ellison JHJ, Gao X, Grey CP, Hardwick LJ, Horwitz G, Janek J, Johnson LR, Jordan JW, Matsuda S, Mondal S, Neale AR, Ortiz-Vitoriano N, Temprano I, Vailaya G, Wachsman ED, Wang H-H, Wu Y, Ye S. 2024. Materials for stable metal–oxygen battery cathodes: general discussion. Faraday Discussions. 248, 75–88.","ama":"Attard GA, Calvo EJ, Curtiss LA, et al. Materials for stable metal–oxygen battery cathodes: general discussion. <i>Faraday Discussions</i>. 2024;248:75-88. doi:<a href=\"https://doi.org/10.1039/d3fd90059b\">10.1039/d3fd90059b</a>","apa":"Attard, G. A., Calvo, E. J., Curtiss, L. A., Dewar, D., Ellison, J. H. J., Gao, X., … Ye, S. (2024). Materials for stable metal–oxygen battery cathodes: general discussion. <i>Faraday Discussions</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d3fd90059b\">https://doi.org/10.1039/d3fd90059b</a>","short":"G.A. Attard, E.J. Calvo, L.A. Curtiss, D. Dewar, J.H.J. Ellison, X. Gao, C.P. Grey, L.J. Hardwick, G. Horwitz, J. Janek, L.R. Johnson, J.W. Jordan, S. Matsuda, S. Mondal, A.R. Neale, N. Ortiz-Vitoriano, I. Temprano, G. Vailaya, E.D. Wachsman, H.-H. Wang, Y. Wu, S. Ye, Faraday Discussions 248 (2024) 75–88.","mla":"Attard, Gary A., et al. “Materials for Stable Metal–Oxygen Battery Cathodes: General Discussion.” <i>Faraday Discussions</i>, vol. 248, Royal Society of Chemistry, 2024, pp. 75–88, doi:<a href=\"https://doi.org/10.1039/d3fd90059b\">10.1039/d3fd90059b</a>."},"article_type":"letter_note","intvolume":"       248","date_updated":"2025-09-04T11:35:09Z"},{"ddc":["576"],"date_updated":"2025-09-04T12:05:42Z","publisher":"Institute of Science and Technology Austria","project":[{"name":"The highjacking of meiosis for asexual reproduction","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","grant_number":"F8810"}],"file":[{"access_level":"open_access","relation":"main_file","creator":"melkrewi","content_type":"text/plain","date_created":"2023-12-22T13:54:21Z","file_size":847,"date_updated":"2023-12-22T13:54:21Z","file_name":"readme.txt.txt","file_id":"14707","success":1,"checksum":"bdaf1392867786634ec5466d528c36ca"},{"file_id":"14708","file_name":"data_artemia_franciscana_genome.zip","date_updated":"2023-12-22T14:14:06Z","checksum":"973e1cbdab923a71709782177980829f","success":1,"file_size":343632753,"date_created":"2023-12-22T14:14:06Z","content_type":"application/x-zip-compressed","access_level":"open_access","creator":"melkrewi","relation":"main_file"}],"doi":"10.15479/AT:ISTA:14705","status":"public","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Since the commercialization of brine shrimp (genus Artemia) in the 1950s, this lineage, and in particular the model species Artemia franciscana, has been the subject of extensive research. However, our understanding of the genetic mechanisms underlying various aspects of their reproductive biology, including sex determination, are still lacking. This is partly due to the scarcity of genomic resources for Artemia species and crustaceans in general. Here, we present a chromosome-level genome assembly of Artemia franciscana (Kellogg 1906), from the Great Salt Lake, USA. The genome is 1GB, and the majority of the genome (81%) is scaffolded into 21 linkage groups using a previously published high-density linkage map. We performed coverage and FST analyses using male and female genomic and transcriptomic reads to quantify the extent of differentiation between the Z and W chromosomes. Additionally, we quantified the expression levels in male and female heads and gonads and found further evidence for dosage compensation in this species."}],"type":"research_data","corr_author":"1","oa_version":"Published Version","date_created":"2023-12-22T13:40:48Z","citation":{"chicago":"Elkrewi, Marwan N. “Data from ‘Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex-Chromosome Differentiation.’” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:14705\">https://doi.org/10.15479/AT:ISTA:14705</a>.","mla":"Elkrewi, Marwan N. <i>Data from “Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex-Chromosome Differentiation.”</i> Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14705\">10.15479/AT:ISTA:14705</a>.","short":"M.N. Elkrewi, (2024).","apa":"Elkrewi, M. N. (2024). Data from “Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:14705\">https://doi.org/10.15479/AT:ISTA:14705</a>","ista":"Elkrewi MN. 2024. Data from ‘Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:14705\">10.15479/AT:ISTA:14705</a>.","ama":"Elkrewi MN. Data from “Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.” 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14705\">10.15479/AT:ISTA:14705</a>","ieee":"M. N. Elkrewi, “Data from ‘Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.’” Institute of Science and Technology Austria, 2024."},"date_published":"2024-01-02T00:00:00Z","_id":"14705","contributor":[{"last_name":"Bett","first_name":"Vincent K","id":"57854184-AAE0-11E9-8D04-98D6E5697425","contributor_type":"researcher"},{"id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","contributor_type":"project_member","last_name":"Macon","first_name":"Ariana"},{"contributor_type":"supervisor","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","first_name":"Beatriz","last_name":"Vicoso"},{"id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","contributor_type":"researcher","last_name":"Elkrewi","first_name":"Marwan N","orcid":"0000-0002-5328-7231"}],"title":"Data from \"Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation\"","oa":1,"file_date_updated":"2023-12-22T14:14:06Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2024","month":"01","department":[{"_id":"GradSch"},{"_id":"BeVi"}],"keyword":["sex chromosome evolution","genome assembly","dosage compensation"],"day":"02","related_material":{"record":[{"status":"public","id":"15009","relation":"used_in_publication"}]},"author":[{"full_name":"Elkrewi, Marwan N","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","last_name":"Elkrewi","orcid":"0000-0002-5328-7231","first_name":"Marwan N"}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"No"},{"day":"19","department":[{"_id":"NiBa"},{"_id":"GradSch"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Local adaptation, genetic load and extinction in metapopulations","oa":1,"article_processing_charge":"No","tmp":{"short":"CC BY-NC-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"publication_identifier":{"issn":["2663-337X"]},"file":[{"date_updated":"2024-01-03T18:30:13Z","file_id":"14730","file_name":"FinalSubmission_Thesis_OLUSANYA.zip","checksum":"de179b1c6758f182ff0c70d8b38c1501","file_size":16986244,"content_type":"application/zip","date_created":"2024-01-03T18:30:13Z","access_level":"closed","relation":"source_file","creator":"oolusany"},{"access_level":"open_access","relation":"main_file","creator":"oolusany","content_type":"application/pdf","date_created":"2024-01-03T18:31:34Z","file_size":6460403,"date_updated":"2024-01-03T18:31:34Z","file_name":"FinalSubmission2_Thesis_OLUSANYA.pdf","file_id":"14731","success":1,"checksum":"0e331585e3cd4823320aab4e69e64ccf"}],"doi":"10.15479/at:ista:14711","publisher":"Institute of Science and Technology Austria","degree_awarded":"PhD","_id":"14711","date_published":"2024-01-19T00:00:00Z","supervisor":[{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H"},{"full_name":"Polechova, Jitka","first_name":"Jitka","last_name":"Polechova"},{"first_name":"Himani","last_name":"Sachdeva","full_name":"Sachdeva, Himani"}],"related_material":{"record":[{"relation":"part_of_dissertation","id":"10787","status":"public"},{"status":"public","id":"10658","relation":"part_of_dissertation"},{"id":"14732","status":"public","relation":"part_of_dissertation"}]},"month":"01","year":"2024","file_date_updated":"2024-01-03T18:31:34Z","publication_status":"published","page":"183","alternative_title":["ISTA Thesis"],"author":[{"first_name":"Oluwafunmilola O","orcid":"0000-0003-1971-8314","last_name":"Olusanya","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","full_name":"Olusanya, Oluwafunmilola O"}],"acknowledged_ssus":[{"_id":"SSU"}],"project":[{"name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"665385"},{"grant_number":"P32896","name":"Causes and consequences of population fragmentation","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"},{"name":"Polygenic Adaptation in a Metapopulation","_id":"34c872fe-11ca-11ed-8bc3-8534b82131e6","grant_number":"26380"}],"OA_place":"publisher","ddc":["576"],"date_updated":"2026-04-07T12:54:29Z","language":[{"iso":"eng"}],"citation":{"chicago":"Olusanya, Oluwafunmilola O. “Local Adaptation, Genetic Load and Extinction in Metapopulations.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:14711\">https://doi.org/10.15479/at:ista:14711</a>.","short":"O.O. Olusanya, Local Adaptation, Genetic Load and Extinction in Metapopulations, Institute of Science and Technology Austria, 2024.","mla":"Olusanya, Oluwafunmilola O. <i>Local Adaptation, Genetic Load and Extinction in Metapopulations</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:14711\">10.15479/at:ista:14711</a>.","ista":"Olusanya OO. 2024. Local adaptation, genetic load and extinction in metapopulations. Institute of Science and Technology Austria.","ieee":"O. O. Olusanya, “Local adaptation, genetic load and extinction in metapopulations,” Institute of Science and Technology Austria, 2024.","ama":"Olusanya OO. Local adaptation, genetic load and extinction in metapopulations. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:14711\">10.15479/at:ista:14711</a>","apa":"Olusanya, O. O. (2024). <i>Local adaptation, genetic load and extinction in metapopulations</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:14711\">https://doi.org/10.15479/at:ista:14711</a>"},"ec_funded":1,"type":"dissertation","corr_author":"1","date_created":"2023-12-26T22:49:53Z","oa_version":"Published Version","status":"public","has_accepted_license":"1","abstract":[{"text":"In nature, different species find their niche in a range of environments, each with its unique characteristics. While some thrive in uniform (homogeneous) landscapes where environmental conditions stay relatively consistent across space, others traverse the complexities of spatially heterogeneous terrains. Comprehending how species are distributed and how they interact within these landscapes holds the key to gaining insights into their evolutionary dynamics while also informing conservation and management strategies.\r\n\r\nFor species inhabiting heterogeneous landscapes, when the rate of dispersal is low compared to spatial fluctuations in selection pressure, localized adaptations may emerge. Such adaptation in response to varying selection strengths plays an important role in the persistence of populations in our rapidly changing world. Hence, species in nature are continuously in a struggle to adapt to local environmental conditions, to ensure their continued survival. Natural populations can often adapt in time scales short enough for evolutionary changes to influence ecological dynamics and vice versa, thereby creating a feedback between evolution and demography. The analysis of this feedback and the relative contributions of gene flow, demography, drift, and natural selection to genetic variation and differentiation has remained a recurring theme in evolutionary biology. Nevertheless, the effective role of these forces in maintaining variation and shaping patterns of diversity is not fully understood. Even in homogeneous environments devoid of local adaptations, such understanding remains elusive. Understanding this feedback is crucial, for example in determining the conditions under which extinction risk can be mitigated in peripheral populations subject to deleterious mutation accumulation at the edges of species’ ranges\r\nas well as in highly fragmented populations.\r\n\r\nIn this thesis we explore both uniform and spatially heterogeneous metapopulations, investigating and providing theoretical insights into the dynamics of local adaptation in the latter and examining the dynamics of load and extinction as well as the impact of joint ecological and evolutionary (eco-evolutionary) dynamics in the former. The thesis is divided into 5 chapters.\r\n\r\nChapter 1 provides a general introduction into the subject matter, clarifying concepts and ideas used throughout the thesis. In chapter 2, we explore how fast a species distributed across a heterogeneous landscape adapts to changing conditions marked by alterations in carrying capacity, selection pressure, and migration rate.\r\n\r\nIn chapter 3, we investigate how migration selection and drift influences adaptation and the maintenance of variation in a metapopulation with three habitats, an extension of previous models of adaptation in two habitats. We further develop analytical approximations for the critical threshold required for polymorphism to persist.\r\n\r\nThe focus of chapter 4 of the thesis is on understanding the interplay between ecology and evolution as coupled processes. We investigate how eco-evolutionary feedback between migration, selection, drift, and demography influences eco-evolutionary outcomes in marginal populations subject to deleterious mutation accumulation. Using simulations as well as theoretical approximations of the coupled dynamics of population size and allele frequency, we analyze how gene flow from a large mainland source influences genetic load and population size on an island (i.e., in a marginal population) under genetically realistic assumptions. Analyses of this sort are important because small isolated populations, are repeatedly affected by complex interactions between ecological and evolutionary processes, which can lead to their death. Understanding these interactions can therefore provide an insight into the conditions under which extinction risk can be mitigated in peripheral populations thus, contributing to conservation and restoration efforts.\r\n\r\nChapter 5 extends the analysis in chapter 4 to consider the dynamics of load (due to deleterious mutation accumulation) and extinction risk in a metapopulation. We explore the role of gene flow, selection, and dominance on load and extinction risk and further pinpoint critical thresholds required for metapopulation persistence.\r\n\r\nOverall this research contributes to our understanding of ecological and evolutionary mechanisms that shape species’ persistence in fragmented landscapes, a crucial foundation for successful conservation efforts and biodiversity management.","lang":"eng"}]},{"_id":"14726","quality_controlled":"1","date_published":"2024-05-01T00:00:00Z","article_number":"koad324","doi":"10.1093/plcell/koad324","publisher":"Oxford University Press","extern":"1","article_processing_charge":"No","publication_identifier":{"eissn":["1532-298X"],"issn":["1040-4651"]},"tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"keyword":["Cell Biology","Plant Science"],"day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize","citation":{"chicago":"Zhou, Liang-Zi, Lele Wang, Xia Chen, Zengxiang Ge, Julia Mergner, Xingli Li, Bernhard Küster, Gernot Längst, Li-Jia Qu, and Thomas Dresselhaus. “The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize.” <i>The Plant Cell</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/plcell/koad324\">https://doi.org/10.1093/plcell/koad324</a>.","apa":"Zhou, L.-Z., Wang, L., Chen, X., Ge, Z., Mergner, J., Li, X., … Dresselhaus, T. (2024). The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. <i>The Plant Cell</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/plcell/koad324\">https://doi.org/10.1093/plcell/koad324</a>","ieee":"L.-Z. Zhou <i>et al.</i>, “The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize,” <i>The Plant Cell</i>, vol. 36, no. 5. Oxford University Press, 2024.","ista":"Zhou L-Z, Wang L, Chen X, Ge Z, Mergner J, Li X, Küster B, Längst G, Qu L-J, Dresselhaus T. 2024. The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. The Plant Cell. 36(5), koad324.","ama":"Zhou L-Z, Wang L, Chen X, et al. The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. <i>The Plant Cell</i>. 2024;36(5). doi:<a href=\"https://doi.org/10.1093/plcell/koad324\">10.1093/plcell/koad324</a>","mla":"Zhou, Liang-Zi, et al. “The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize.” <i>The Plant Cell</i>, vol. 36, no. 5, koad324, Oxford University Press, 2024, doi:<a href=\"https://doi.org/10.1093/plcell/koad324\">10.1093/plcell/koad324</a>.","short":"L.-Z. Zhou, L. Wang, X. Chen, Z. Ge, J. Mergner, X. Li, B. Küster, G. Längst, L.-J. Qu, T. Dresselhaus, The Plant Cell 36 (2024)."},"article_type":"original","language":[{"iso":"eng"}],"publication":"The Plant Cell","date_created":"2024-01-02T11:19:37Z","scopus_import":"1","oa_version":"Published Version","main_file_link":[{"url":"https://doi.org/10.1093/plcell/koad324","open_access":"1"}],"type":"journal_article","abstract":[{"text":"Autocrine signaling pathways regulated by RAPID ALKALINIZATION FACTORs (RALFs) control cell wall integrity during pollen tube germination and growth in Arabidopsis (Arabidopsis thaliana). To investigate the role of pollen-specific RALFs in another plant species, we combined gene expression data with phylogenetic and biochemical studies to identify candidate orthologs in maize (Zea mays). We show that Clade IB ZmRALF2/3 mutations, but not Clade III ZmRALF1/5 mutations, cause cell wall instability in the sub-apical region of the growing pollen tube. ZmRALF2/3 are mainly located in the cell wall and are partially able to complement the pollen germination defect of their Arabidopsis orthologs AtRALF4/19. Mutations in ZmRALF2/3 compromise pectin distribution patterns leading to altered cell wall organization and thickness culminating in pollen tube burst. Clade IB, but not Clade III ZmRALFs, strongly interact as ligands with the pollen-specific Catharanthus roseus RLK1-like (CrRLK1L) receptor kinases Zea mays FERONIA-like (ZmFERL) 4/7/9, LORELEI-like glycosylphosphatidylinositol-anchor (LLG) proteins Zea mays LLG 1 and 2 (ZmLLG1/2) and Zea mays pollen extension-like (PEX) cell wall proteins ZmPEX2/4. Notably, ZmFERL4 outcompetes ZmLLG2 and ZmPEX2 outcompetes ZmFERL4 for ZmRALF2 binding. Based on these data, we suggest that Clade IB RALFs act in a dual role as cell wall components and extracellular sensors to regulate cell wall integrity and thickness during pollen tube growth in maize and probably other plants.","lang":"eng"}],"external_id":{"pmid":["38142229"]},"has_accepted_license":"1","status":"public","intvolume":"        36","date_updated":"2024-07-16T11:18:46Z","ddc":["580"],"pmid":1,"author":[{"first_name":"Liang-Zi","last_name":"Zhou","full_name":"Zhou, Liang-Zi"},{"full_name":"Wang, Lele","first_name":"Lele","last_name":"Wang"},{"last_name":"Chen","first_name":"Xia","full_name":"Chen, Xia"},{"first_name":"Zengxiang","orcid":"0000-0001-9381-3577","last_name":"Ge","id":"f43371a3-09ff-11eb-8013-bd0c6a2f6de8","full_name":"Ge, Zengxiang"},{"full_name":"Mergner, Julia","first_name":"Julia","last_name":"Mergner"},{"full_name":"Li, Xingli","first_name":"Xingli","last_name":"Li"},{"last_name":"Küster","first_name":"Bernhard","full_name":"Küster, Bernhard"},{"full_name":"Längst, Gernot","last_name":"Längst","first_name":"Gernot"},{"full_name":"Qu, Li-Jia","first_name":"Li-Jia","last_name":"Qu"},{"first_name":"Thomas","last_name":"Dresselhaus","full_name":"Dresselhaus, Thomas"}],"issue":"5","volume":36,"month":"05","year":"2024","publication_status":"published"},{"department":[{"_id":"StFr"}],"keyword":["Electrical and Electronic Engineering","Materials Chemistry","Electrochemistry","Energy Engineering and Power Technology","Chemical Engineering (miscellaneous)"],"day":"22","title":"Exploring the landscape of heterocyclic quinones for redox flow batteries","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["2574-0962"]},"article_processing_charge":"Yes (in subscription journal)","publisher":"American Chemical Society","isi":1,"doi":"10.1021/acsaem.3c02223","file":[{"file_size":5607177,"file_id":"17262","file_name":"2024_ACSAppElecMaterials_Jethwa.pdf","date_updated":"2024-07-16T11:59:24Z","success":1,"checksum":"2841e86a041d249ac0df2531b7f9aec1","access_level":"open_access","creator":"dernst","relation":"main_file","date_created":"2024-07-16T11:59:24Z","content_type":"application/pdf"}],"_id":"14733","date_published":"2024-01-22T00:00:00Z","quality_controlled":"1","month":"01","volume":7,"issue":"2","publication_status":"published","file_date_updated":"2024-07-16T11:59:24Z","year":"2024","page":"414-426","pmid":1,"author":[{"last_name":"Jethwa","first_name":"Rajesh B","orcid":"0000-0002-0404-4356","id":"4cc538d5-803f-11ed-ab7e-8139573aad8f","full_name":"Jethwa, Rajesh B"},{"first_name":"Dominic","last_name":"Hey","full_name":"Hey, Dominic"},{"full_name":"Kerber, Rachel N.","first_name":"Rachel N.","last_name":"Kerber"},{"first_name":"Andrew D.","last_name":"Bond","full_name":"Bond, Andrew D."},{"first_name":"Dominic S.","last_name":"Wright","full_name":"Wright, Dominic S."},{"first_name":"Clare P.","last_name":"Grey","full_name":"Grey, Clare P."}],"project":[{"call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413"}],"ddc":["540"],"date_updated":"2025-09-04T11:36:32Z","intvolume":"         7","language":[{"iso":"eng"}],"ec_funded":1,"citation":{"ama":"Jethwa RB, Hey D, Kerber RN, Bond AD, Wright DS, Grey CP. Exploring the landscape of heterocyclic quinones for redox flow batteries. <i>ACS Applied Energy Materials</i>. 2024;7(2):414-426. doi:<a href=\"https://doi.org/10.1021/acsaem.3c02223\">10.1021/acsaem.3c02223</a>","ieee":"R. B. Jethwa, D. Hey, R. N. Kerber, A. D. Bond, D. S. Wright, and C. P. Grey, “Exploring the landscape of heterocyclic quinones for redox flow batteries,” <i>ACS Applied Energy Materials</i>, vol. 7, no. 2. American Chemical Society, pp. 414–426, 2024.","ista":"Jethwa RB, Hey D, Kerber RN, Bond AD, Wright DS, Grey CP. 2024. Exploring the landscape of heterocyclic quinones for redox flow batteries. ACS Applied Energy Materials. 7(2), 414–426.","apa":"Jethwa, R. B., Hey, D., Kerber, R. N., Bond, A. D., Wright, D. S., &#38; Grey, C. P. (2024). Exploring the landscape of heterocyclic quinones for redox flow batteries. <i>ACS Applied Energy Materials</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsaem.3c02223\">https://doi.org/10.1021/acsaem.3c02223</a>","short":"R.B. Jethwa, D. Hey, R.N. Kerber, A.D. Bond, D.S. Wright, C.P. Grey, ACS Applied Energy Materials 7 (2024) 414–426.","mla":"Jethwa, Rajesh B., et al. “Exploring the Landscape of Heterocyclic Quinones for Redox Flow Batteries.” <i>ACS Applied Energy Materials</i>, vol. 7, no. 2, American Chemical Society, 2024, pp. 414–26, doi:<a href=\"https://doi.org/10.1021/acsaem.3c02223\">10.1021/acsaem.3c02223</a>.","chicago":"Jethwa, Rajesh B, Dominic Hey, Rachel N. Kerber, Andrew D. Bond, Dominic S. Wright, and Clare P. Grey. “Exploring the Landscape of Heterocyclic Quinones for Redox Flow Batteries.” <i>ACS Applied Energy Materials</i>. American Chemical Society, 2024. <a href=\"https://doi.org/10.1021/acsaem.3c02223\">https://doi.org/10.1021/acsaem.3c02223</a>."},"article_type":"original","external_id":{"isi":["001146733200001"],"pmid":["38273966"]},"status":"public","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Redox flow batteries (RFBs) rely on the development of cheap, highly soluble, and high-energy-density electrolytes. Several candidate quinones have already been investigated in the literature as two-electron anolytes or catholytes, benefiting from fast kinetics, high tunability, and low cost. Here, an investigation of nitrogen-rich fused heteroaromatic quinones was carried out to explore avenues for electrolyte development. These quinones were synthesized and screened by using electrochemical techniques. The most promising candidate, 4,8-dioxo-4,8-dihydrobenzo[1,2-d:4,5-d′]bis([1,2,3]triazole)-1,5-diide (−0.68 V(SHE)), was tested in both an asymmetric and symmetric full-cell setup resulting in capacity fade rates of 0.35% per cycle and 0.0124% per cycle, respectively. In situ ultraviolet-visible spectroscopy (UV–Vis), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR) spectroscopies were used to investigate the electrochemical stability of the charged species during operation. UV–Vis spectroscopy, supported by density functional theory (DFT) modeling, reaffirmed that the two-step charging mechanism observed during battery operation consisted of two, single-electron transfers. The radical concentration during battery operation and the degree of delocalization of the unpaired electron were quantified with NMR and EPR spectroscopy."}],"type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1021/acsaem.3c02223","open_access":"1"}],"publication":"ACS Applied Energy Materials","scopus_import":"1","date_created":"2024-01-05T09:20:48Z","oa_version":"Published Version"},{"date_published":"2024-08-01T00:00:00Z","_id":"14734","quality_controlled":"1","article_number":"2301377","doi":"10.1002/smtd.202301377","isi":1,"acknowledgement":"Y.L. acknowledges funding from the National Natural Science Foundation of China (NSFC) (Grants No. 22209034), the Innovation and Entrepreneurship Project of Overseas Returnees in Anhui Province (Grant No. 2022LCX002). K.H.L. acknowledges financial support from the National Natural Science Foundation of China (NSFC) (Grant No. 22208293). M.I. acknowledges financial support from ISTA and the Werner Siemens Foundation.","publisher":"Wiley","article_processing_charge":"No","publication_identifier":{"eissn":["2366-9608"]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4","day":"01","department":[{"_id":"MaIb"}],"oa_version":"None","scopus_import":"1","publication":"Small Methods","date_created":"2024-01-07T23:00:51Z","type":"journal_article","abstract":[{"text":"Developing cost-effective and high-performance thermoelectric (TE) materials to assemble efficient TE devices presents a multitude of challenges and opportunities. Cu3SbSe4 is a promising p-type TE material based on relatively earth abundant elements. However, the challenge lies in its poor electrical conductivity. Herein, an efficient and scalable solution-based approach is developed to synthesize high-quality Cu3SbSe4 nanocrystals doped with Pb at the Sb site. After ligand displacement and annealing treatments, the dried powders are consolidated into dense pellets, and their TE properties are investigated. Pb doping effectively increases the charge carrier concentration, resulting in a significant increase in electrical conductivity, while the Seebeck coefficients remain consistently high. The calculated band structure shows that Pb doping induces band convergence, thereby increasing the effective mass. Furthermore, the large ionic radius of Pb2+ results in the generation of additional point and plane defects and interphases, dramatically enhancing phonon scattering, which significantly decreases the lattice thermal conductivity at high temperatures. Overall, a maximum figure of merit (zTmax) ≈ 0.85 at 653 K is obtained in Cu3Sb0.97Pb0.03Se4. This represents a 1.6-fold increase compared to the undoped sample and exceeds most doped Cu3SbSe4-based materials produced by solid-state, demonstrating advantages of versatility and cost-effectiveness using a solution-based technology.","lang":"eng"}],"status":"public","external_id":{"pmid":["38152986"],"isi":["001133369800001"]},"article_type":"original","citation":{"apa":"Wan, S., Xiao, S., Li, M., Wang, X., Lim, K. H., Hong, M., … Liu, Y. (2024). Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4. <i>Small Methods</i>. Wiley. <a href=\"https://doi.org/10.1002/smtd.202301377\">https://doi.org/10.1002/smtd.202301377</a>","ista":"Wan S, Xiao S, Li M, Wang X, Lim KH, Hong M, Ibáñez M, Cabot A, Liu Y. 2024. Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4. Small Methods. 8(8), 2301377.","ama":"Wan S, Xiao S, Li M, et al. Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4. <i>Small Methods</i>. 2024;8(8). doi:<a href=\"https://doi.org/10.1002/smtd.202301377\">10.1002/smtd.202301377</a>","ieee":"S. Wan <i>et al.</i>, “Band engineering through Pb-doping of nanocrystal building blocks to enhance thermoelectric performance in Cu3SbSe4,” <i>Small Methods</i>, vol. 8, no. 8. Wiley, 2024.","mla":"Wan, Shanhong, et al. “Band Engineering through Pb-Doping of Nanocrystal Building Blocks to Enhance Thermoelectric Performance in Cu3SbSe4.” <i>Small Methods</i>, vol. 8, no. 8, 2301377, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/smtd.202301377\">10.1002/smtd.202301377</a>.","short":"S. Wan, S. Xiao, M. Li, X. Wang, K.H. Lim, M. Hong, M. Ibáñez, A. Cabot, Y. Liu, Small Methods 8 (2024).","chicago":"Wan, Shanhong, Shanshan Xiao, Mingquan Li, Xin Wang, Khak Ho Lim, Min Hong, Maria Ibáñez, Andreu Cabot, and Yu Liu. “Band Engineering through Pb-Doping of Nanocrystal Building Blocks to Enhance Thermoelectric Performance in Cu3SbSe4.” <i>Small Methods</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/smtd.202301377\">https://doi.org/10.1002/smtd.202301377</a>."},"language":[{"iso":"eng"}],"intvolume":"         8","date_updated":"2025-09-04T11:37:19Z","project":[{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"}],"OA_type":"closed access","author":[{"first_name":"Shanhong","last_name":"Wan","full_name":"Wan, Shanhong"},{"full_name":"Xiao, Shanshan","first_name":"Shanshan","last_name":"Xiao"},{"full_name":"Li, Mingquan","last_name":"Li","first_name":"Mingquan"},{"full_name":"Wang, Xin","last_name":"Wang","first_name":"Xin"},{"full_name":"Lim, Khak Ho","first_name":"Khak Ho","last_name":"Lim"},{"first_name":"Min","last_name":"Hong","full_name":"Hong, Min"},{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","full_name":"Ibáñez, Maria","first_name":"Maria","orcid":"0000-0001-5013-2843","last_name":"Ibáñez"},{"full_name":"Cabot, Andreu","first_name":"Andreu","last_name":"Cabot"},{"full_name":"Liu, Yu","id":"2A70014E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7313-6740","first_name":"Yu","last_name":"Liu"}],"pmid":1,"year":"2024","publication_status":"published","issue":"8","volume":8,"month":"08"},{"quality_controlled":"1","_id":"14769","date_published":"2024-01-04T00:00:00Z","conference":{"start_date":"2024-01-07","location":"Alexandria, VA, United States","end_date":"2024-01-08","name":"ALENEX: Workshop on Algorithm Engineering and Experiments"},"publisher":"Society for Industrial and Applied Mathematics","acknowledgement":"This   project   has   received   funding   from   the   Euro-pean  Research  Council  (ERC)  under  the  EuropeanUnion’s  Horizon  2020  research  and  innovation  programme  (Grant  agreement  No.   101019564  “The  De-sign  of  Modern  Fully  Dynamic  Data  Structures  (Mo-DynStruct)”  and  the  Austrian  Science  Fund  (FWF)project Z 422-N, project “Static and Dynamic Hierar-chical  Graph  Decompositions”,  I  5982-N,  and  project“Fast  Algorithms  for  a  Reactive  Network  Layer  (Re-actNet)”, P 33775-N, with additional funding from thenetidee SCIENCE Stiftung, 2020–2024.D.  Sauplic  has  received  funding  from  the  Euro-pean  Union’s  Horizon  2020  research  and  innovation programme under the Marie Sklodowska-Curie    grant    agreementNo 101034413.","doi":"10.1137/1.9781611977929.17","publication_identifier":{"eisbn":["9781611977929"]},"article_processing_charge":"No","title":"Experimental evaluation of fully dynamic k-means via coresets","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MoHe"}],"day":"04","external_id":{"arxiv":["2310.18034"]},"status":"public","abstract":[{"text":"For a set of points in Rd, the Euclidean k-means problems consists of finding k centers such that the sum of distances squared from each data point to its closest center is minimized. Coresets are one the main tools developed recently to solve this problem in a big data context. They allow to compress the initial dataset while preserving its structure: running any algorithm on the coreset provides a guarantee almost equivalent to running it on the full data. In this work, we study coresets in a fully-dynamic setting: points are added and deleted with the goal to efficiently maintain a coreset with which a k-means solution can be computed. Based on an algorithm from Henzinger and Kale [ESA'20], we present an efficient and practical implementation of a fully dynamic coreset algorithm, that improves the running time by up to a factor of 20 compared to our non-optimized implementation of the algorithm by Henzinger and Kale, without sacrificing more than 7% on the quality of the k-means solution.","lang":"eng"}],"type":"conference","corr_author":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2310.18034"}],"date_created":"2024-01-09T16:22:47Z","publication":"2024 Proceedings of the Symposium on Algorithm Engineering and Experiments","oa_version":"Preprint","scopus_import":"1","language":[{"iso":"eng"}],"citation":{"chicago":"Henzinger, Monika, David Saulpic, and Leonhard Sidl. “Experimental Evaluation of Fully Dynamic K-Means via Coresets.” In <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>, 220–33. Society for Industrial and Applied Mathematics, 2024. <a href=\"https://doi.org/10.1137/1.9781611977929.17\">https://doi.org/10.1137/1.9781611977929.17</a>.","apa":"Henzinger, M., Saulpic, D., &#38; Sidl, L. (2024). Experimental evaluation of fully dynamic k-means via coresets. In <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i> (pp. 220–233). Alexandria, VA, United States: Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/1.9781611977929.17\">https://doi.org/10.1137/1.9781611977929.17</a>","ista":"Henzinger M, Saulpic D, Sidl L. 2024. Experimental evaluation of fully dynamic k-means via coresets. 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments. ALENEX: Workshop on Algorithm Engineering and Experiments, 220–233.","ieee":"M. Henzinger, D. Saulpic, and L. Sidl, “Experimental evaluation of fully dynamic k-means via coresets,” in <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>, Alexandria, VA, United States, 2024, pp. 220–233.","ama":"Henzinger M, Saulpic D, Sidl L. Experimental evaluation of fully dynamic k-means via coresets. In: <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>. Society for Industrial and Applied Mathematics; 2024:220-233. doi:<a href=\"https://doi.org/10.1137/1.9781611977929.17\">10.1137/1.9781611977929.17</a>","mla":"Henzinger, Monika, et al. “Experimental Evaluation of Fully Dynamic K-Means via Coresets.” <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>, Society for Industrial and Applied Mathematics, 2024, pp. 220–33, doi:<a href=\"https://doi.org/10.1137/1.9781611977929.17\">10.1137/1.9781611977929.17</a>.","short":"M. Henzinger, D. Saulpic, L. Sidl, in:, 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments, Society for Industrial and Applied Mathematics, 2024, pp. 220–233."},"ec_funded":1,"arxiv":1,"date_updated":"2025-04-14T13:50:50Z","project":[{"grant_number":"101019564","_id":"bd9ca328-d553-11ed-ba76-dc4f890cfe62","name":"The design and evaluation of modern fully dynamic data structures","call_identifier":"H2020"},{"grant_number":"Z00422","name":"Efficient algorithms","_id":"34def286-11ca-11ed-8bc3-da5948e1613c"},{"grant_number":"I05982","_id":"bda196b2-d553-11ed-ba76-8e8ee6c21103","name":"Static and Dynamic Hierarchical Graph Decompositions"},{"name":"Fast Algorithms for a Reactive Network Layer","_id":"bd9e3a2e-d553-11ed-ba76-8aa684ce17fe","grant_number":"P33775"},{"call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413"}],"author":[{"last_name":"Henzinger","first_name":"Monika H","orcid":"0000-0002-5008-6530","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","full_name":"Henzinger, Monika H"},{"id":"f8e48cf0-b0ff-11ed-b0e9-b4c35598f964","full_name":"Saulpic, David","last_name":"Saulpic","first_name":"David"},{"id":"8b563fd0-b441-11ee-9101-a3891c61efa6","full_name":"Sidl, Leonhard","first_name":"Leonhard","last_name":"Sidl"}],"page":"220-233","publication_status":"published","year":"2024","month":"01"},{"_id":"14794","date_published":"2024-03-15T00:00:00Z","quality_controlled":"1","article_number":"102795","doi":"10.1016/j.xpro.2023.102795","acknowledgement":"We thank Florian Pauler for discussion and his expert technical support. This research was supported by the Scientific Service Units (SSU) at IST Austria through resources provided by the Imaging and Optics Facility (IOF) and Preclinical Facility (PCF). A.H.H. was a recipient of a DOC Fellowship (24812) of the Austrian Academy of Sciences.","file":[{"relation":"main_file","creator":"dernst","access_level":"open_access","date_created":"2024-07-16T12:04:46Z","content_type":"application/pdf","file_size":3758943,"success":1,"checksum":"4644d537451c5c114a9d7c7829b65bba","date_updated":"2024-07-16T12:04:46Z","file_name":"2024_STARProtoc_Hansen.pdf","file_id":"17264"}],"publisher":"Elsevier","article_processing_charge":"Yes","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["2666-1667"]},"day":"15","department":[{"_id":"SiHi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers","oa":1,"language":[{"iso":"eng"}],"article_type":"review","citation":{"mla":"Hansen, Andi H., and Simon Hippenmeyer. “Time-Lapse Imaging of Cortical Projection Neuron Migration in Mice Using Mosaic Analysis with Double Markers.” <i>STAR Protocols</i>, vol. 5, no. 1, 102795, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">10.1016/j.xpro.2023.102795</a>.","short":"A.H. Hansen, S. Hippenmeyer, STAR Protocols 5 (2024).","apa":"Hansen, A. H., &#38; Hippenmeyer, S. (2024). Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. <i>STAR Protocols</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">https://doi.org/10.1016/j.xpro.2023.102795</a>","ista":"Hansen AH, Hippenmeyer S. 2024. Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. STAR Protocols. 5(1), 102795.","ieee":"A. H. Hansen and S. Hippenmeyer, “Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers,” <i>STAR Protocols</i>, vol. 5, no. 1. Elsevier, 2024.","ama":"Hansen AH, Hippenmeyer S. Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. <i>STAR Protocols</i>. 2024;5(1). doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">10.1016/j.xpro.2023.102795</a>","chicago":"Hansen, Andi H, and Simon Hippenmeyer. “Time-Lapse Imaging of Cortical Projection Neuron Migration in Mice Using Mosaic Analysis with Double Markers.” <i>STAR Protocols</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">https://doi.org/10.1016/j.xpro.2023.102795</a>."},"type":"journal_article","corr_author":"1","publication":"STAR Protocols","scopus_import":"1","date_created":"2024-01-14T23:00:56Z","oa_version":"Published Version","external_id":{"pmid":["38165800"]},"status":"public","has_accepted_license":"1","abstract":[{"text":"Mosaic analysis with double markers (MADM) technology enables the sparse labeling of genetically defined neurons. We present a protocol for time-lapse imaging of cortical projection neuron migration in mice using MADM. We describe steps for the isolation, culturing, and 4D imaging of neuronal dynamics in MADM-labeled brain tissue. While this protocol is compatible with other single-cell labeling methods, the MADM approach provides a genetic platform for the functional assessment of cell-autonomous candidate gene function and the relative contribution of non-cell-autonomous effects.\r\n\r\nFor complete details on the use and execution of this protocol, please refer to Hansen et al. (2022),1 Contreras et al. (2021),2 and Amberg and Hippenmeyer (2021).3","lang":"eng"}],"project":[{"_id":"2625A13E-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of radial neuronal migration","grant_number":"24812"}],"intvolume":"         5","ddc":["570"],"date_updated":"2025-04-15T07:32:40Z","pmid":1,"author":[{"last_name":"Hansen","first_name":"Andi H","full_name":"Hansen, Andi H","id":"38853E16-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","first_name":"Simon"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"volume":5,"issue":"1","related_material":{"link":[{"url":"http://github.com/hippenmeyerlab","relation":"software"}]},"month":"03","year":"2024","publication_status":"published","file_date_updated":"2024-07-16T12:04:46Z"},{"volume":34,"issue":"1","month":"01","year":"2024","file_date_updated":"2024-01-16T10:53:31Z","publication_status":"published","pmid":1,"page":"171-182.e8","author":[{"last_name":"Arslan","first_name":"Feyza N","orcid":"0000-0001-5809-9566","id":"49DA7910-F248-11E8-B48F-1D18A9856A87","full_name":"Arslan, Feyza N"},{"last_name":"Hannezo","orcid":"0000-0001-6005-1561","first_name":"Edouard B","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Merrin","orcid":"0000-0001-5145-4609","first_name":"Jack","full_name":"Merrin, Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-7309-9724","first_name":"Martin","last_name":"Loose","full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"project":[{"grant_number":"742573","call_identifier":"H2020","_id":"260F1432-B435-11E9-9278-68D0E5697425","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation"}],"intvolume":"        34","ddc":["570"],"date_updated":"2025-09-04T11:39:10Z","language":[{"iso":"eng"}],"article_type":"original","citation":{"apa":"Arslan, F. N., Hannezo, E. B., Merrin, J., Loose, M., &#38; Heisenberg, C.-P. J. (2024). Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">https://doi.org/10.1016/j.cub.2023.11.067</a>","ieee":"F. N. Arslan, E. B. Hannezo, J. Merrin, M. Loose, and C.-P. J. Heisenberg, “Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts,” <i>Current Biology</i>, vol. 34, no. 1. Elsevier, p. 171–182.e8, 2024.","ista":"Arslan FN, Hannezo EB, Merrin J, Loose M, Heisenberg C-PJ. 2024. Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. Current Biology. 34(1), 171–182.e8.","ama":"Arslan FN, Hannezo EB, Merrin J, Loose M, Heisenberg C-PJ. Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. <i>Current Biology</i>. 2024;34(1):171-182.e8. doi:<a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">10.1016/j.cub.2023.11.067</a>","mla":"Arslan, Feyza N., et al. “Adhesion-Induced Cortical Flows Pattern E-Cadherin-Mediated Cell Contacts.” <i>Current Biology</i>, vol. 34, no. 1, Elsevier, 2024, p. 171–182.e8, doi:<a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">10.1016/j.cub.2023.11.067</a>.","short":"F.N. Arslan, E.B. Hannezo, J. Merrin, M. Loose, C.-P.J. Heisenberg, Current Biology 34 (2024) 171–182.e8.","chicago":"Arslan, Feyza N, Edouard B Hannezo, Jack Merrin, Martin Loose, and Carl-Philipp J Heisenberg. “Adhesion-Induced Cortical Flows Pattern E-Cadherin-Mediated Cell Contacts.” <i>Current Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">https://doi.org/10.1016/j.cub.2023.11.067</a>."},"ec_funded":1,"type":"journal_article","corr_author":"1","date_created":"2024-01-14T23:00:56Z","publication":"Current Biology","scopus_import":"1","oa_version":"Published Version","external_id":{"isi":["001154500400001"],"pmid":["38134934"]},"has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"Metazoan development relies on the formation and remodeling of cell-cell contacts. Dynamic reorganization of adhesion receptors and the actomyosin cell cortex in space and time plays a central role in cell-cell contact formation and maturation. Nevertheless, how this process is mechanistically achieved when new contacts are formed remains unclear. Here, by building a biomimetic assay composed of progenitor cells adhering to supported lipid bilayers functionalized with E-cadherin ectodomains, we show that cortical F-actin flows, driven by the depletion of myosin-2 at the cell contact center, mediate the dynamic reorganization of adhesion receptors and cell cortex at the contact. E-cadherin-dependent downregulation of the small GTPase RhoA at the forming contact leads to both a depletion of myosin-2 and a decrease of F-actin at the contact center. At the contact rim, in contrast, myosin-2 becomes enriched by the retraction of bleb-like protrusions, resulting in a cortical tension gradient from the contact rim to its center. This tension gradient, in turn, triggers centrifugal F-actin flows, leading to further accumulation of F-actin at the contact rim and the progressive redistribution of E-cadherin from the contact center to the rim. Eventually, this combination of actomyosin downregulation and flows at the contact determines the characteristic molecular organization, with E-cadherin and F-actin accumulating at the contact rim, where they are needed to mechanically link the contractile cortices of the adhering cells."}],"day":"08","department":[{"_id":"CaHe"},{"_id":"EdHa"},{"_id":"MaLo"},{"_id":"NanoFab"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts","oa":1,"article_processing_charge":"Yes (via OA deal)","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"acknowledgement":"We are grateful to Edwin Munro for their feedback and help with the single particle analysis. We thank members of the Heisenberg and Loose labs for their help and feedback on the manuscript, notably Xin Tong for making the PCS2-mCherry-AHPH plasmid. Finally, we thank the Aquatics and Imaging & Optics facilities of ISTA for their continuous support, especially Yann Cesbron for assistance with the laser cutter. This work was supported by an ERC\r\nAdvanced Grant (MECSPEC) to C.-P.H.","file":[{"file_size":5183861,"file_id":"14813","file_name":"2024_CurrentBiology_Arslan.pdf","date_updated":"2024-01-16T10:53:31Z","checksum":"51220b76d72a614208f84bdbfbaf9b72","success":1,"access_level":"open_access","creator":"dernst","relation":"main_file","date_created":"2024-01-16T10:53:31Z","content_type":"application/pdf"}],"doi":"10.1016/j.cub.2023.11.067","isi":1,"publisher":"Elsevier","date_published":"2024-01-08T00:00:00Z","_id":"14795","quality_controlled":"1"},{"page":"485-541","author":[{"id":"fea1b376-906f-11eb-847d-b2c0cf46455b","full_name":"Clozeau, Nicolas","first_name":"Nicolas","last_name":"Clozeau"},{"first_name":"Francesco","last_name":"Mattesini","full_name":"Mattesini, Francesco"}],"month":"10","volume":190,"file_date_updated":"2025-01-09T08:10:54Z","publication_status":"published","year":"2024","ec_funded":1,"article_type":"original","citation":{"ama":"Clozeau N, Mattesini F. Annealed quantitative estimates for the quadratic 2D-discrete random matching problem. <i>Probability Theory and Related Fields</i>. 2024;190:485-541. doi:<a href=\"https://doi.org/10.1007/s00440-023-01254-0\">10.1007/s00440-023-01254-0</a>","ieee":"N. Clozeau and F. Mattesini, “Annealed quantitative estimates for the quadratic 2D-discrete random matching problem,” <i>Probability Theory and Related Fields</i>, vol. 190. Springer Nature, pp. 485–541, 2024.","ista":"Clozeau N, Mattesini F. 2024. Annealed quantitative estimates for the quadratic 2D-discrete random matching problem. Probability Theory and Related Fields. 190, 485–541.","apa":"Clozeau, N., &#38; Mattesini, F. (2024). Annealed quantitative estimates for the quadratic 2D-discrete random matching problem. <i>Probability Theory and Related Fields</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00440-023-01254-0\">https://doi.org/10.1007/s00440-023-01254-0</a>","short":"N. Clozeau, F. Mattesini, Probability Theory and Related Fields 190 (2024) 485–541.","mla":"Clozeau, Nicolas, and Francesco Mattesini. “Annealed Quantitative Estimates for the Quadratic 2D-Discrete Random Matching Problem.” <i>Probability Theory and Related Fields</i>, vol. 190, Springer Nature, 2024, pp. 485–541, doi:<a href=\"https://doi.org/10.1007/s00440-023-01254-0\">10.1007/s00440-023-01254-0</a>.","chicago":"Clozeau, Nicolas, and Francesco Mattesini. “Annealed Quantitative Estimates for the Quadratic 2D-Discrete Random Matching Problem.” <i>Probability Theory and Related Fields</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s00440-023-01254-0\">https://doi.org/10.1007/s00440-023-01254-0</a>."},"language":[{"iso":"eng"}],"abstract":[{"text":"We study a random matching problem on closed compact  2 -dimensional Riemannian manifolds (with respect to the squared Riemannian distance), with samples of random points whose common law is absolutely continuous with respect to the volume measure with strictly positive and bounded density. We show that given two sequences of numbers  n  and  m=m(n)  of points, asymptotically equivalent as  n  goes to infinity, the optimal transport plan between the two empirical measures  μn  and  νm  is quantitatively well-approximated by  (Id,exp(∇hn))#μn  where  hn  solves a linear elliptic PDE obtained by a regularized first-order linearization of the Monge-Ampère equation. This is obtained in the case of samples of correlated random points for which a stretched exponential decay of the  α -mixing coefficient holds and for a class of discrete-time Markov chains having a unique absolutely continuous invariant measure with respect to the volume measure.","lang":"eng"}],"has_accepted_license":"1","status":"public","external_id":{"arxiv":["2303.00353"],"isi":["001136206200002"]},"date_created":"2024-01-14T23:00:57Z","oa_version":"Published Version","publication":"Probability Theory and Related Fields","scopus_import":"1","type":"journal_article","corr_author":"1","OA_type":"hybrid","project":[{"grant_number":"948819","name":"Bridging Scales in Random Materials","call_identifier":"H2020","_id":"0aa76401-070f-11eb-9043-b5bb049fa26d"}],"date_updated":"2025-09-04T11:43:43Z","ddc":["510"],"arxiv":1,"intvolume":"       190","OA_place":"publisher","publication_identifier":{"eissn":["1432-2064"],"issn":["0178-8051"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"Yes (in subscription journal)","department":[{"_id":"JuFi"}],"day":"01","oa":1,"title":"Annealed quantitative estimates for the quadratic 2D-discrete random matching problem","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"14797","quality_controlled":"1","date_published":"2024-10-01T00:00:00Z","publisher":"Springer Nature","acknowledgement":"NC has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No 948819).\r\nFM is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through the SPP 2265 Random Geometric Systems. FM has been funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2044 -390685587, Mathematics Münster: Dynamics–Geometry–Structure. FM has been funded by the Max Planck Institute for Mathematics in the Sciences.","doi":"10.1007/s00440-023-01254-0","isi":1,"file":[{"file_name":"2024_ProbTheoryRelatFields_Clozeau.pdf","file_id":"18788","date_updated":"2025-01-09T08:10:54Z","checksum":"34f44cad6a210ff66791ee37e590af2c","success":1,"file_size":880117,"content_type":"application/pdf","date_created":"2025-01-09T08:10:54Z","access_level":"open_access","creator":"dernst","relation":"main_file"}]},{"intvolume":"       989","ddc":["000"],"date_updated":"2025-12-02T14:02:37Z","project":[{"grant_number":"863818","name":"Formal Methods for Stochastic Models: Algorithms and Applications","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020"}],"corr_author":"1","type":"journal_article","publication":"Theoretical Computer Science","scopus_import":"1","oa_version":"Published Version","date_created":"2024-01-16T13:40:41Z","has_accepted_license":"1","status":"public","external_id":{"isi":["001168211400001"]},"abstract":[{"text":"We consider a natural problem dealing with weighted packet selection across a rechargeable link, which e.g., finds applications in cryptocurrency networks. The capacity of a link (u, v) is determined by how many nodes u and v allocate for this link. Specifically, the input is a finite ordered sequence of packets that arrive in both directions along a link. Given (u, v) and a packet of weight x going from u to v, node u can either accept or reject the packet. If u accepts the packet, the capacity on link (u, v) decreases by x. Correspondingly, v's capacity on \r\n increases by x. If a node rejects the packet, this will entail a cost affinely linear in the weight of the packet. A link is “rechargeable” in the sense that the total capacity of the link has to remain constant, but the allocation of capacity at the ends of the link can depend arbitrarily on the nodes' decisions. The goal is to minimise the sum of the capacity injected into the link and the cost of rejecting packets. We show that the problem is NP-hard, but can be approximated efficiently with a ratio of (1+E) . (1+3)  for some arbitrary E>0.","lang":"eng"}],"language":[{"iso":"eng"}],"citation":{"chicago":"Schmid, Stefan, Jakub Svoboda, and Michelle X Yeo. “Weighted Packet Selection for Rechargeable Links in Cryptocurrency Networks: Complexity and Approximation.” <i>Theoretical Computer Science</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.tcs.2023.114353\">https://doi.org/10.1016/j.tcs.2023.114353</a>.","apa":"Schmid, S., Svoboda, J., &#38; Yeo, M. X. (2024). Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation. <i>Theoretical Computer Science</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tcs.2023.114353\">https://doi.org/10.1016/j.tcs.2023.114353</a>","ama":"Schmid S, Svoboda J, Yeo MX. Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation. <i>Theoretical Computer Science</i>. 2024;989. doi:<a href=\"https://doi.org/10.1016/j.tcs.2023.114353\">10.1016/j.tcs.2023.114353</a>","ista":"Schmid S, Svoboda J, Yeo MX. 2024. Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation. Theoretical Computer Science. 989, 114353.","ieee":"S. Schmid, J. Svoboda, and M. X. Yeo, “Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation,” <i>Theoretical Computer Science</i>, vol. 989. Elsevier, 2024.","mla":"Schmid, Stefan, et al. “Weighted Packet Selection for Rechargeable Links in Cryptocurrency Networks: Complexity and Approximation.” <i>Theoretical Computer Science</i>, vol. 989, 114353, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.tcs.2023.114353\">10.1016/j.tcs.2023.114353</a>.","short":"S. Schmid, J. Svoboda, M.X. Yeo, Theoretical Computer Science 989 (2024)."},"article_type":"original","ec_funded":1,"year":"2024","file_date_updated":"2024-07-16T12:02:25Z","publication_status":"published","volume":989,"related_material":{"record":[{"relation":"earlier_version","id":"19985","status":"public"}]},"month":"03","author":[{"full_name":"Schmid, Stefan","last_name":"Schmid","first_name":"Stefan"},{"id":"130759D2-D7DD-11E9-87D2-DE0DE6697425","full_name":"Svoboda, Jakub","first_name":"Jakub","orcid":"0000-0002-1419-3267","last_name":"Svoboda"},{"orcid":"0009-0001-3676-4809","first_name":"Michelle X","last_name":"Yeo","full_name":"Yeo, Michelle X","id":"2D82B818-F248-11E8-B48F-1D18A9856A87"}],"doi":"10.1016/j.tcs.2023.114353","file":[{"relation":"main_file","creator":"dernst","access_level":"open_access","date_created":"2024-07-16T12:02:25Z","content_type":"application/pdf","file_size":603570,"success":1,"checksum":"efd5b7e738bf845312ba53889a3e13e4","date_updated":"2024-07-16T12:02:25Z","file_id":"17263","file_name":"2024_TheorComputerScience_Schmid.pdf"}],"acknowledgement":"We thank Mahsa Bastankhah and Mohammad Ali Maddah-Ali for fruitful discussions about different variants of the problem. This work is supported by the European Research Council (ERC) Consolidator Project 864228 (AdjustNet), 2020-2025, the ERC CoG 863818 (ForM-SMArt), and the German Research Foundation (DFG) grant 470029389 (FlexNets), 2021-2024.","isi":1,"publisher":"Elsevier","quality_controlled":"1","_id":"14820","date_published":"2024-03-21T00:00:00Z","article_number":"114353","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Weighted packet selection for rechargeable links in cryptocurrency networks: Complexity and approximation","oa":1,"keyword":["General Computer Science","Theoretical Computer Science"],"day":"21","department":[{"_id":"KrCh"},{"_id":"KrPi"}],"article_processing_charge":"Yes (via OA deal)","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["0304-3975"]}},{"publication":"ACS Applied Energy Materials","date_created":"2024-01-17T12:48:35Z","oa_version":"None","scopus_import":"1","corr_author":"1","type":"journal_article","abstract":[{"lang":"eng","text":"Production of hydrogen at large scale requires development of non-noble, inexpensive, and high-performing catalysts for constructing water-splitting devices. Herein, we report the synthesis of Zn-doped NiO heterostructure (ZnNiO) catalysts at room temperature via a coprecipitation method followed by drying (at 80 °C, 6 h) and calcination at an elevated temperature of 400 °C for 5 h under three distinct conditions, namely, air, N2, and vacuum. The vacuum-synthesized catalyst demonstrates a low overpotential of 88 mV at −10 mA cm–2 and a small Tafel slope of 73 mV dec–1 suggesting relatively higher charge transfer kinetics for hydrogen evolution reactions (HER) compared with the specimens synthesized under N2 or O2 atmosphere. It also demonstrates an oxygen evolution (OER) overpotential of 260 mV at 10 mA cm–2 with a low Tafel slope of 63 mV dec–1. In a full-cell water-splitting device, the vacuum-synthesized ZnNiO heterostructure demonstrates a cell voltage of 1.94 V at 50 mA cm–2 and shows remarkable stability over 24 h at a high current density of 100 mA cm–2. It is also demonstrated in this study that Zn-doping, surface, and interface engineering in transition-metal oxides play a crucial role in efficient electrocatalytic water splitting. Also, the results obtained from density functional theory (DFT + U = 0–8 eV), where U is the on-site Coulomb repulsion parameter also known as Hubbard U, based electronic structure calculations confirm that Zn doping constructively modifies the electronic structure, in both the valence band and the conduction band, and found to be suitable in tailoring the carrier’s effective masses of electrons and holes. The decrease in electron’s effective masses together with large differences between the effective masses of electrons and holes is noticed, which is found to be mainly responsible for achieving the best water-splitting performance from a 9% Zn-doped NiO sample prepared under vacuum."}],"external_id":{"isi":["001138342900001"]},"status":"public","article_type":"original","citation":{"short":"G.K. Kiran, S. Singh, N. Mahato, T.V.M. Sreekanth, G.R. Dillip, K. Yoo, J. Kim, ACS Applied Energy Materials 7 (2024) 214–229.","mla":"Kiran, Gundegowda Kalligowdanadoddi, et al. “Interface Engineering Modulation Combined with Electronic Structure Modification of Zn-Doped NiO Heterostructure for Efficient Water-Splitting Activity.” <i>ACS Applied Energy Materials</i>, vol. 7, no. 1, American Chemical Society, 2024, pp. 214–29, doi:<a href=\"https://doi.org/10.1021/acsaem.3c02519\">10.1021/acsaem.3c02519</a>.","ama":"Kiran GK, Singh S, Mahato N, et al. Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity. <i>ACS Applied Energy Materials</i>. 2024;7(1):214-229. doi:<a href=\"https://doi.org/10.1021/acsaem.3c02519\">10.1021/acsaem.3c02519</a>","ista":"Kiran GK, Singh S, Mahato N, Sreekanth TVM, Dillip GR, Yoo K, Kim J. 2024. Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity. ACS Applied Energy Materials. 7(1), 214–229.","ieee":"G. K. Kiran <i>et al.</i>, “Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity,” <i>ACS Applied Energy Materials</i>, vol. 7, no. 1. American Chemical Society, pp. 214–229, 2024.","apa":"Kiran, G. K., Singh, S., Mahato, N., Sreekanth, T. V. M., Dillip, G. R., Yoo, K., &#38; Kim, J. (2024). Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity. <i>ACS Applied Energy Materials</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsaem.3c02519\">https://doi.org/10.1021/acsaem.3c02519</a>","chicago":"Kiran, Gundegowda Kalligowdanadoddi, Saurabh Singh, Neelima Mahato, Thupakula Venkata Madhukar Sreekanth, Gowra Raghupathy Dillip, Kisoo Yoo, and Jonghoon Kim. “Interface Engineering Modulation Combined with Electronic Structure Modification of Zn-Doped NiO Heterostructure for Efficient Water-Splitting Activity.” <i>ACS Applied Energy Materials</i>. American Chemical Society, 2024. <a href=\"https://doi.org/10.1021/acsaem.3c02519\">https://doi.org/10.1021/acsaem.3c02519</a>."},"language":[{"iso":"eng"}],"intvolume":"         7","date_updated":"2024-10-09T21:07:53Z","author":[{"full_name":"Kiran, Gundegowda Kalligowdanadoddi","first_name":"Gundegowda Kalligowdanadoddi","last_name":"Kiran"},{"last_name":"Singh","first_name":"Saurabh","orcid":"0000-0003-2209-5269","id":"12d625da-9cb3-11ed-9667-af09d37d3f0a","full_name":"Singh, Saurabh"},{"full_name":"Mahato, Neelima","last_name":"Mahato","first_name":"Neelima"},{"first_name":"Thupakula Venkata Madhukar","last_name":"Sreekanth","full_name":"Sreekanth, Thupakula Venkata Madhukar"},{"last_name":"Dillip","first_name":"Gowra Raghupathy","full_name":"Dillip, Gowra Raghupathy"},{"last_name":"Yoo","first_name":"Kisoo","full_name":"Yoo, Kisoo"},{"full_name":"Kim, Jonghoon","first_name":"Jonghoon","last_name":"Kim"}],"page":"214-229","year":"2024","publication_status":"published","issue":"1","volume":7,"month":"01","_id":"14828","quality_controlled":"1","date_published":"2024-01-08T00:00:00Z","doi":"10.1021/acsaem.3c02519","acknowledgement":"This work was supported by the Technology Innovation Program (20011622, Development of Battery System Applied High-Efficiency Heat Control Polymer and Part Component) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). Author acknowledge to Prof. Tsunehiro Takeuchi from Toyota Technological Institute, Nagoya, Japan for the support of computational resources.","isi":1,"publisher":"American Chemical Society","article_processing_charge":"No","publication_identifier":{"issn":["2574-0962"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity","day":"08","keyword":["Electrical and Electronic Engineering","Materials Chemistry","Electrochemistry","Energy Engineering and Power Technology","Chemical Engineering (miscellaneous)"],"department":[{"_id":"MaIb"}]},{"type":"journal_article","corr_author":"1","publication":"European Journal of Cell Biology","scopus_import":"1","date_created":"2024-01-18T08:16:43Z","oa_version":"Published Version","external_id":{"pmid":["38218128"],"isi":["001166216800001"]},"has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"Bacteria divide by binary fission. The protein machine responsible for this process is the divisome, a transient assembly of more than 30 proteins in and on the surface of the cytoplasmic membrane. Together, they constrict the cell envelope and remodel the peptidoglycan layer to eventually split the cell into two. For Escherichia coli, most molecular players involved in this process have probably been identified, but obtaining the quantitative information needed for a mechanistic understanding can often not be achieved from experiments in vivo alone. Since the discovery of the Z-ring more than 30 years ago, in vitro reconstitution experiments have been crucial to shed light on molecular processes normally hidden in the complex environment of the living cell. In this review, we summarize how rebuilding the divisome from purified components – or at least parts of it - have been instrumental to obtain the detailed mechanistic understanding of the bacterial cell division machinery that we have today."}],"language":[{"iso":"eng"}],"article_type":"review","citation":{"apa":"Radler, P., &#38; Loose, M. (2024). A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches. <i>European Journal of Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ejcb.2023.151380\">https://doi.org/10.1016/j.ejcb.2023.151380</a>","ieee":"P. Radler and M. Loose, “A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches,” <i>European Journal of Cell Biology</i>, vol. 103, no. 1. Elsevier, 2024.","ista":"Radler P, Loose M. 2024. A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches. European Journal of Cell Biology. 103(1), 151380.","ama":"Radler P, Loose M. A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches. <i>European Journal of Cell Biology</i>. 2024;103(1). doi:<a href=\"https://doi.org/10.1016/j.ejcb.2023.151380\">10.1016/j.ejcb.2023.151380</a>","mla":"Radler, Philipp, and Martin Loose. “A Dynamic Duo: Understanding the Roles of FtsZ and FtsA for Escherichia Coli Cell Division through in Vitro Approaches.” <i>European Journal of Cell Biology</i>, vol. 103, no. 1, 151380, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.ejcb.2023.151380\">10.1016/j.ejcb.2023.151380</a>.","short":"P. Radler, M. Loose, European Journal of Cell Biology 103 (2024).","chicago":"Radler, Philipp, and Martin Loose. “A Dynamic Duo: Understanding the Roles of FtsZ and FtsA for Escherichia Coli Cell Division through in Vitro Approaches.” <i>European Journal of Cell Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.ejcb.2023.151380\">https://doi.org/10.1016/j.ejcb.2023.151380</a>."},"intvolume":"       103","ddc":["570"],"date_updated":"2025-09-04T11:45:31Z","project":[{"grant_number":"P34607","_id":"fc38323b-9c52-11eb-aca3-ff8afb4a011d","name":"In vitro reconstitution of bacterial cell division"}],"author":[{"full_name":"Radler, Philipp","id":"40136C2A-F248-11E8-B48F-1D18A9856A87","last_name":"Radler","orcid":"0000-0001-9198-2182 ","first_name":"Philipp"},{"id":"462D4284-F248-11E8-B48F-1D18A9856A87","full_name":"Loose, Martin","last_name":"Loose","first_name":"Martin","orcid":"0000-0001-7309-9724"}],"pmid":1,"year":"2024","file_date_updated":"2024-07-16T12:07:20Z","publication_status":"published","volume":103,"issue":"1","month":"03","date_published":"2024-03-01T00:00:00Z","_id":"14834","quality_controlled":"1","article_number":"151380","isi":1,"file":[{"file_size":9995304,"file_id":"17265","file_name":"2024_EJCB_Radler.pdf","date_updated":"2024-07-16T12:07:20Z","checksum":"5d170abbc87585205c010657e4552360","success":1,"access_level":"open_access","creator":"dernst","relation":"main_file","content_type":"application/pdf","date_created":"2024-07-16T12:07:20Z"}],"acknowledgement":"We acknowledge members of the Loose laboratory at ISTA for helpful discussions—in particular M. Kojic for his insightful comments. This work was supported by the Austrian Science Fund (FWF P34607) to M.L.","doi":"10.1016/j.ejcb.2023.151380","publisher":"Elsevier","article_processing_charge":"Yes","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["0171-9335"]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches","oa":1,"day":"01","keyword":["Cell Biology","General Medicine","Histology","Pathology and Forensic Medicine"],"department":[{"_id":"MaLo"}]},{"tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"publication_identifier":{"eissn":["1091-6490"]},"article_processing_charge":"Yes (in subscription journal)","department":[{"_id":"TiVo"}],"day":"16","title":"A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_number":"e2307776121","quality_controlled":"1","_id":"14841","date_published":"2024-01-16T00:00:00Z","publisher":"National Academy of Sciences","file":[{"checksum":"f498c643be81895dd3a69ee90115a782","success":1,"date_updated":"2025-04-23T13:51:16Z","file_name":"2024_PNAS_Clatot.pdf","file_id":"19613","file_size":3060109,"date_created":"2025-04-23T13:51:16Z","content_type":"application/pdf","relation":"main_file","creator":"dernst","access_level":"open_access"}],"isi":1,"acknowledgement":"This work was supported by an ERC Consolidator Grant (SYNAPSEEK) to T.P.V., the NOMIS Foundation through the NOMIS Fellowships program at IST Austria to C.B.C., a Jefferson Synaptic Biology Center Pilot Project Grant to M.C., NIH NINDS U54 NS108874 (PI, Alfred L. George), and NIH NINDS R01 NS122887 to E.M.G. The computations were enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC) at the PDC Center for High-Performance Computing, KTH Royal Institute of Technology, partially funded by the Swedish Research Council through grant agreement no. 2018-05973. We thank Akshay Sridhar for the fruitful discussion of the project.","doi":"10.1073/pnas.2307776121","pmid":1,"author":[{"first_name":"Jerome","last_name":"Clatot","full_name":"Clatot, Jerome"},{"first_name":"Christopher","orcid":"0000-0002-4809-5059","last_name":"Currin","id":"e8321fc5-3091-11eb-8a53-83f309a11ac9","full_name":"Currin, Christopher"},{"full_name":"Liang, Qiansheng","last_name":"Liang","first_name":"Qiansheng"},{"full_name":"Pipatpolkai, Tanadet","first_name":"Tanadet","last_name":"Pipatpolkai"},{"last_name":"Massey","first_name":"Shavonne L.","full_name":"Massey, Shavonne L."},{"last_name":"Helbig","first_name":"Ingo","full_name":"Helbig, Ingo"},{"full_name":"Delemotte, Lucie","last_name":"Delemotte","first_name":"Lucie"},{"last_name":"Vogels","first_name":"Tim P","orcid":"0000-0003-3295-6181","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","full_name":"Vogels, Tim P"},{"first_name":"Manuel","last_name":"Covarrubias","full_name":"Covarrubias, Manuel"},{"first_name":"Ethan M.","last_name":"Goldberg","full_name":"Goldberg, Ethan M."}],"month":"01","volume":121,"issue":"3","related_material":{"link":[{"relation":"software","url":"https://github.com/ChrisCurrin/pv-kcnc2 "}]},"file_date_updated":"2025-04-23T13:51:16Z","publication_status":"published","year":"2024","language":[{"iso":"eng"}],"ec_funded":1,"article_type":"original","citation":{"short":"J. Clatot, C. Currin, Q. Liang, T. Pipatpolkai, S.L. Massey, I. Helbig, L. Delemotte, T.P. Vogels, M. Covarrubias, E.M. Goldberg, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).","mla":"Clatot, Jerome, et al. “A Structurally Precise Mechanism Links an Epilepsy-Associated KCNC2 Potassium Channel Mutation to Interneuron Dysfunction.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 3, e2307776121, National Academy of Sciences, 2024, doi:<a href=\"https://doi.org/10.1073/pnas.2307776121\">10.1073/pnas.2307776121</a>.","ama":"Clatot J, Currin C, Liang Q, et al. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2024;121(3). doi:<a href=\"https://doi.org/10.1073/pnas.2307776121\">10.1073/pnas.2307776121</a>","ieee":"J. Clatot <i>et al.</i>, “A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 3. National Academy of Sciences, 2024.","ista":"Clatot J, Currin C, Liang Q, Pipatpolkai T, Massey SL, Helbig I, Delemotte L, Vogels TP, Covarrubias M, Goldberg EM. 2024. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 121(3), e2307776121.","apa":"Clatot, J., Currin, C., Liang, Q., Pipatpolkai, T., Massey, S. L., Helbig, I., … Goldberg, E. M. (2024). A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2307776121\">https://doi.org/10.1073/pnas.2307776121</a>","chicago":"Clatot, Jerome, Christopher Currin, Qiansheng Liang, Tanadet Pipatpolkai, Shavonne L. Massey, Ingo Helbig, Lucie Delemotte, Tim P Vogels, Manuel Covarrubias, and Ethan M. Goldberg. “A Structurally Precise Mechanism Links an Epilepsy-Associated KCNC2 Potassium Channel Mutation to Interneuron Dysfunction.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2024. <a href=\"https://doi.org/10.1073/pnas.2307776121\">https://doi.org/10.1073/pnas.2307776121</a>."},"has_accepted_license":"1","external_id":{"isi":["001167401000001"],"pmid":["38194456"]},"status":"public","abstract":[{"lang":"eng","text":"De novo heterozygous variants in KCNC2 encoding the voltage-gated potassium (K+) channel subunit Kv3.2 are a recently described cause of developmental and epileptic encephalopathy (DEE). A de novo variant in KCNC2 c.374G > A (p.Cys125Tyr) was identified via exome sequencing in a patient with DEE. Relative to wild-type Kv3.2, Kv3.2-p.Cys125Tyr induces K+ currents exhibiting a large hyperpolarizing shift in the voltage dependence of activation, accelerated activation, and delayed deactivation consistent with a relative stabilization of the open conformation, along with increased current density. Leveraging the cryogenic electron microscopy (cryo-EM) structure of Kv3.1, molecular dynamic simulations suggest that a strong π-π stacking interaction between the variant Tyr125 and Tyr156 in the α-6 helix of the T1 domain promotes a relative stabilization of the open conformation of the channel, which underlies the observed gain of function. A multicompartment computational model of a Kv3-expressing parvalbumin-positive cerebral cortex fast-spiking γ-aminobutyric acidergic (GABAergic) interneuron (PV-IN) demonstrates how the Kv3.2-Cys125Tyr variant impairs neuronal excitability and dysregulates inhibition in cerebral cortex circuits to explain the resulting epilepsy."}],"type":"journal_article","oa_version":"Published Version","scopus_import":"1","date_created":"2024-01-21T23:00:56Z","publication":"Proceedings of the National Academy of Sciences of the United States of America","OA_type":"hybrid","project":[{"grant_number":"819603","name":"Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning.","call_identifier":"H2020","_id":"0aacfa84-070f-11eb-9043-d7eb2c709234"}],"ddc":["570"],"date_updated":"2025-09-04T11:47:47Z","intvolume":"       121","OA_place":"publisher"}]