[{"acknowledgement":"The authors thank Ms. Katrin Muck for her guidance related to the use of HPC. The MC\r\ncomputer simulation results presented here were enabled via a generous share of CPU time, offered by the Vienna Scientific Cluster (VSC) under Project No. 71263. A. J. A. gratefully acknowledges support from the EPSRC under Grant No. EP/P015689/1. This research was funded in part by the Austrian Science Fund (FWF) [Grant DOI: 10.55776/PIN8759524], gratefully acknowledged by G. K .","has_accepted_license":"1","file":[{"date_created":"2026-04-28T06:58:40Z","relation":"main_file","access_level":"open_access","checksum":"8ffb139122a185fcddbe6a9c901a287c","file_size":4336488,"success":1,"file_name":"2026_PhysicalReviewLetters_Wassermair.pdf","file_id":"21769","date_updated":"2026-04-28T06:58:40Z","creator":"dernst","content_type":"application/pdf"}],"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","author":[{"id":"23d132c4-4e98-11ef-b275-9e8d4cd8c917","full_name":"Wassermair, Michael","orcid":"0009-0003-6339-4051","last_name":"Wassermair","first_name":"Michael"},{"last_name":"Kahl","first_name":"Gerhard","full_name":"Kahl, Gerhard"},{"full_name":"Roth, Roland","first_name":"Roland","last_name":"Roth"},{"full_name":"Archer, Andrew J.","last_name":"Archer","first_name":"Andrew J."}],"arxiv":1,"external_id":{"arxiv":["2603.18918"]},"issue":"14","intvolume":" 136","publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"_id":"21764","quality_controlled":"1","date_published":"2026-04-10T00:00:00Z","status":"public","month":"04","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"department":[{"_id":"AnSa"},{"_id":"GradSch"}],"date_created":"2026-04-26T22:01:47Z","publisher":"American Physical Society","citation":{"ista":"Wassermair M, Kahl G, Roth R, Archer AJ. 2026. Navigating complex phase diagrams in soft matter systems. Physical Review Letters. 136(14), 148203.","short":"M. Wassermair, G. Kahl, R. Roth, A.J. Archer, Physical Review Letters 136 (2026).","mla":"Wassermair, Michael, et al. “Navigating Complex Phase Diagrams in Soft Matter Systems.” Physical Review Letters, vol. 136, no. 14, 148203, American Physical Society, 2026, doi:10.1103/nbvt-fgjy.","chicago":"Wassermair, Michael, Gerhard Kahl, Roland Roth, and Andrew J. Archer. “Navigating Complex Phase Diagrams in Soft Matter Systems.” Physical Review Letters. American Physical Society, 2026. https://doi.org/10.1103/nbvt-fgjy.","ama":"Wassermair M, Kahl G, Roth R, Archer AJ. Navigating complex phase diagrams in soft matter systems. Physical Review Letters. 2026;136(14). doi:10.1103/nbvt-fgjy","ieee":"M. Wassermair, G. Kahl, R. Roth, and A. J. Archer, “Navigating complex phase diagrams in soft matter systems,” Physical Review Letters, vol. 136, no. 14. American Physical Society, 2026.","apa":"Wassermair, M., Kahl, G., Roth, R., & Archer, A. J. (2026). Navigating complex phase diagrams in soft matter systems. Physical Review Letters. American Physical Society. https://doi.org/10.1103/nbvt-fgjy"},"language":[{"iso":"eng"}],"article_number":"148203","abstract":[{"text":"Colloidal fluids can exhibit complex phase behavior and determining phase diagrams via experiments or computer simulations can be laborious. We demonstrate that the dispersion relation ω(k), obtained from dynamical density functional theory for the uniform density system, is a highly versatile tool for predicting where in the phase diagram complex crystals form. The sign of ω(k) determines whether density modes with wave number k grow or decay over time. We demonstrate the predictive power by investigating the complex phase behavior of particles interacting via core-shoulder pair potentials. With complementary Monte Carlo simulations, we show that regions of the phase diagram where ωðkÞ has one or several unstable (growing) wave numbers are also where crystalline phases occur. Going further, by tuning these\r\nunstable wave numbers via the interaction-potential and state-point parameters, we design systems with quasicrystals in the phase diagram. We identify a system with a certain shoulder range exhibiting at least ten different phases. Our general approach accelerates considerably the mapping of complex phase diagrams, crucial for the design of new materials.","lang":"eng"}],"OA_type":"hybrid","day":"10","oa":1,"title":"Navigating complex phase diagrams in soft matter systems","volume":136,"year":"2026","doi":"10.1103/nbvt-fgjy","publication_status":"published","file_date_updated":"2026-04-28T06:58:40Z","ddc":["530"],"scopus_import":"1","PlanS_conform":"1","date_updated":"2026-04-28T07:03:48Z","publication":"Physical Review Letters","type":"journal_article","license":"https://creativecommons.org/licenses/by/4.0/","article_processing_charge":"Yes (in subscription journal)","article_type":"original"},{"OA_type":"closed access","day":"01","year":"2026","volume":10,"title":"Particle size scaling of non-Gaussian granular charge distributions","language":[{"iso":"eng"}],"article_number":"045604","abstract":[{"lang":"eng","text":"Dielectric particles of the same material exchange electrical charge during collisions or sliding contacts, yet the underlying charge-exchange mechanism is still not understood. The fact that particles can become highly charged as a result of this effect has significant consequences for many settings, both in nature and industry, such as thunderstorms, volcanic eruptions, particle aggregation during meteorite and planet formation, and the clogging of industrial granular systems. Toward understanding these systems, great efforts have been made to develop precise in situ measurements for particle charge, e.g., to determine ensemble charge distributions or measure exchange during individual contacts. Here, we present experimental results concerning the particle size scaling of the stationary-state charge distributions of oxide particles in the sub-millimeter range. We measure the charge distributions for large ensembles of monodisperse ZrO2:SiO2 composite spheres, ranging from 172 to 545µm in diameter. These distributions are non-Gaussian and collapse to a single master curve when plotted as functions of the surface charge density Σ=𝑞/4𝜋𝑅2. X-ray fluorescence and atomic force microscopy measurements show that the differences in the measured charge distributions are not due to variations in chemical composition or surface roughness, but rather to size alone. Our findings provide constraints on microscopic models for charge exchange, namely that they should lead to steady-state distributions that are non-Gaussian and scale in a specific way with particle size."}],"doi":"10.1103/qw6t-xqdw","publication_status":"published","publication":"Physical Review Materials","type":"journal_article","date_updated":"2026-04-28T07:13:56Z","scopus_import":"1","article_processing_charge":"No","article_type":"original","acknowledgement":"This research was supported by ANID Grants QUIMAL No. 160001, FONDECYT No. 1221597, and FONDEQUIP No. EQM190177. The authors thank Rodrigo Espinoza for the EDS-SEM measurements and Domingo Jullian for fruitful discussions. We also acknowledge the technical assistance of Ricardo Silva and Andrés Espinosa at DFI, FCFM, Universidad de Chile.","author":[{"first_name":"Macarena","last_name":"Lara","full_name":"Lara, Macarena"},{"first_name":"Marcos","last_name":"Flores","full_name":"Flores, Marcos"},{"first_name":"Gustavo","last_name":"Castillo","full_name":"Castillo, Gustavo"},{"first_name":"Santiago","last_name":"Tassara","full_name":"Tassara, Santiago"},{"last_name":"Waitukaitis","first_name":"Scott R","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2299-3176","full_name":"Waitukaitis, Scott R"},{"full_name":"Mujica, Nicolás","last_name":"Mujica","first_name":"Nicolás"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"None","quality_controlled":"1","date_published":"2026-04-01T00:00:00Z","_id":"21765","intvolume":" 10","issue":"4","publication_identifier":{"eissn":["2475-9953"]},"date_created":"2026-04-26T22:01:47Z","department":[{"_id":"ScWa"}],"publisher":"American Physical Society","citation":{"ista":"Lara M, Flores M, Castillo G, Tassara S, Waitukaitis SR, Mujica N. 2026. Particle size scaling of non-Gaussian granular charge distributions. Physical Review Materials. 10(4), 045604.","short":"M. Lara, M. Flores, G. Castillo, S. Tassara, S.R. Waitukaitis, N. Mujica, Physical Review Materials 10 (2026).","mla":"Lara, Macarena, et al. “Particle Size Scaling of Non-Gaussian Granular Charge Distributions.” Physical Review Materials, vol. 10, no. 4, 045604, American Physical Society, 2026, doi:10.1103/qw6t-xqdw.","chicago":"Lara, Macarena, Marcos Flores, Gustavo Castillo, Santiago Tassara, Scott R Waitukaitis, and Nicolás Mujica. “Particle Size Scaling of Non-Gaussian Granular Charge Distributions.” Physical Review Materials. American Physical Society, 2026. https://doi.org/10.1103/qw6t-xqdw.","ama":"Lara M, Flores M, Castillo G, Tassara S, Waitukaitis SR, Mujica N. Particle size scaling of non-Gaussian granular charge distributions. Physical Review Materials. 2026;10(4). doi:10.1103/qw6t-xqdw","ieee":"M. Lara, M. Flores, G. Castillo, S. Tassara, S. R. Waitukaitis, and N. Mujica, “Particle size scaling of non-Gaussian granular charge distributions,” Physical Review Materials, vol. 10, no. 4. American Physical Society, 2026.","apa":"Lara, M., Flores, M., Castillo, G., Tassara, S., Waitukaitis, S. R., & Mujica, N. (2026). Particle size scaling of non-Gaussian granular charge distributions. Physical Review Materials. American Physical Society. https://doi.org/10.1103/qw6t-xqdw"},"month":"04","status":"public"},{"oa_version":"Published Version","related_material":{"record":[{"id":"17361","status":"public","relation":"earlier_version"}]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","author":[{"last_name":"Bauer","first_name":"Martin","full_name":"Bauer, Martin"},{"last_name":"Ishida","first_name":"Sadashige","id":"6F7C4B96-A8E9-11E9-A7CA-09ECE5697425","orcid":"0000-0002-3121-3100","full_name":"Ishida, Sadashige"},{"last_name":"Michor","first_name":"Peter W.","full_name":"Michor, Peter W."}],"external_id":{"arxiv":["2407.19908"]},"arxiv":1,"has_accepted_license":"1","acknowledgement":"The authors are grateful to Boris Khesin for valuable comments on the MW symplectic structure and S. Ishida thanks Albert Chern for insightful discussions on space curves and Chris Wojtan for his continuous support. M. Bauer was partially supported by NSF grant DMS-1953244 and by the Binational Science Foundation (BSF). S. Ishida was partially supported by ERC Consolidator Grant 101045083 “CoDiNA” funded by the European Research Council. Some figures were generated by the software Houdini and its education license was provided by SideFX. Open access funding provided by University of Vienna.","file":[{"file_name":"2026_JourNonlinearScience_Bauer.pdf","success":1,"checksum":"760de2631b6fd7d57bcd5115ed36c0a2","file_size":1108518,"date_created":"2026-04-28T09:55:32Z","access_level":"open_access","relation":"main_file","creator":"dernst","content_type":"application/pdf","date_updated":"2026-04-28T09:55:32Z","file_id":"21770"}],"status":"public","month":"04","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_created":"2026-04-16T07:29:17Z","department":[{"_id":"GradSch"},{"_id":"ChWo"}],"citation":{"ieee":"M. Bauer, S. Ishida, and P. W. Michor, “Symplectic structures on the space of space curves,” Journal of Nonlinear Science, vol. 36, no. 2. Springer Nature, 2026.","ama":"Bauer M, Ishida S, Michor PW. Symplectic structures on the space of space curves. Journal of Nonlinear Science. 2026;36(2). doi:10.1007/s00332-026-10266-8","apa":"Bauer, M., Ishida, S., & Michor, P. W. (2026). Symplectic structures on the space of space curves. Journal of Nonlinear Science. Springer Nature. https://doi.org/10.1007/s00332-026-10266-8","mla":"Bauer, Martin, et al. “Symplectic Structures on the Space of Space Curves.” Journal of Nonlinear Science, vol. 36, no. 2, 45, Springer Nature, 2026, doi:10.1007/s00332-026-10266-8.","short":"M. Bauer, S. Ishida, P.W. Michor, Journal of Nonlinear Science 36 (2026).","ista":"Bauer M, Ishida S, Michor PW. 2026. Symplectic structures on the space of space curves. Journal of Nonlinear Science. 36(2), 45.","chicago":"Bauer, Martin, Sadashige Ishida, and Peter W. Michor. “Symplectic Structures on the Space of Space Curves.” Journal of Nonlinear Science. Springer Nature, 2026. https://doi.org/10.1007/s00332-026-10266-8."},"publisher":"Springer Nature","intvolume":" 36","issue":"2","publication_identifier":{"issn":["0938-8974"],"eissn":["1432-1467"]},"_id":"21743","quality_controlled":"1","project":[{"name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088","grant_number":"101045083"}],"date_published":"2026-04-15T00:00:00Z","doi":"10.1007/s00332-026-10266-8","publication_status":"published","file_date_updated":"2026-04-28T09:55:32Z","article_number":"45","language":[{"iso":"eng"}],"abstract":[{"text":"We present symplectic structures on the shape space of unparameterized space curves that generalize the classical Marsden–Weinstein structure. Our method integrates the Liouville 1-form of the Marsden–Weinstein structure with Riemannian structures that have been introduced in mathematical shape analysis. We also derive Hamiltonian vector fields for several classical Hamiltonian functions with respect to these new symplectic structures.","lang":"eng"}],"OA_type":"hybrid","day":"15","oa":1,"volume":36,"title":"Symplectic structures on the space of space curves","year":"2026","article_processing_charge":"Yes (via OA deal)","article_type":"original","ddc":["510"],"scopus_import":"1","date_updated":"2026-04-28T09:59:01Z","PlanS_conform":"1","type":"journal_article","publication":"Journal of Nonlinear Science"},{"oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"repository","author":[{"last_name":"Chern","first_name":"Albert","full_name":"Chern, Albert"},{"first_name":"Sadashige","last_name":"Ishida","full_name":"Ishida, Sadashige","id":"6F7C4B96-A8E9-11E9-A7CA-09ECE5697425","orcid":"0000-0002-3121-3100"}],"external_id":{"arxiv":["2602.09958"]},"arxiv":1,"keyword":["l’Hopital theorem","complex functions"],"acknowledgement":"This project was funded in part by the European Research Council (ERC Consolidator Grant 101045083 CoDiNA) and the National Science Foundation CAREER Award 2239062.\r\n","has_accepted_license":"1","file":[{"file_size":867109,"checksum":"6a76591c723d3e949ad5afa9f7dbb2ee","success":1,"file_name":"2026_arXiv_2602.09958.pdf","date_created":"2026-04-28T10:53:27Z","relation":"main_file","access_level":"open_access","creator":"dernst","content_type":"application/pdf","date_updated":"2026-04-28T10:53:27Z","file_id":"21771"}],"status":"public","month":"02","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"department":[{"_id":"GradSch"},{"_id":"ChWo"}],"date_created":"2026-04-15T16:28:24Z","citation":{"chicago":"Chern, Albert, and Sadashige Ishida. “L’Hopital Rules for Complex-Valued Functions in Higher Dimensions.” ArXiv, n.d. https://doi.org/10.48550/ARXIV.2602.09958.","ista":"Chern A, Ishida S. L’Hopital rules for complex-valued functions in higher dimensions. arXiv, 2602.09958.","short":"A. Chern, S. Ishida, ArXiv (n.d.).","mla":"Chern, Albert, and Sadashige Ishida. “L’Hopital Rules for Complex-Valued Functions in Higher Dimensions.” ArXiv, 2602.09958, doi:10.48550/ARXIV.2602.09958.","apa":"Chern, A., & Ishida, S. (n.d.). L’Hopital rules for complex-valued functions in higher dimensions. arXiv. https://doi.org/10.48550/ARXIV.2602.09958","ama":"Chern A, Ishida S. L’Hopital rules for complex-valued functions in higher dimensions. arXiv. doi:10.48550/ARXIV.2602.09958","ieee":"A. Chern and S. Ishida, “L’Hopital rules for complex-valued functions in higher dimensions,” arXiv. ."},"_id":"21737","project":[{"grant_number":"101045083","name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088"}],"date_published":"2026-02-10T00:00:00Z","doi":"10.48550/ARXIV.2602.09958","publication_status":"submitted","file_date_updated":"2026-04-28T10:53:27Z","language":[{"iso":"eng"}],"article_number":"2602.09958","corr_author":"1","abstract":[{"lang":"eng","text":"In calculus, l'Hopital's rule provides a simple way to evaluate the limits of quotient functions when both the numerator and denominator vanish. But what happens when we move beyond real functions on a real interval? In this article, we study when the quotient of two complex-valued functions in higher dimension can be defined continuously at the points where both functions vanish. Surprisingly, the answer is far subtler than in the real-valued setting. We provide a complete characterization for the continuity of the quotient function. We also point out why extending this result to smoother quotients remains an intriguing challenge."}],"day":"10","OA_type":"green","oa":1,"title":"L'Hopital rules for complex-valued functions in higher dimensions","year":"2026","article_processing_charge":"No","ddc":["510"],"date_updated":"2026-04-28T10:56:30Z","type":"preprint","publication":"arXiv"},{"main_file_link":[{"url":"https://doi.org/10.1177/00236772251400976","open_access":"1"}],"publication_status":"epub_ahead","doi":"10.1177/00236772251400976","title":"Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science","year":"2026","OA_type":"hybrid","day":"14","oa":1,"abstract":[{"text":"The involvement of non-scientific staff in discussions about animal welfare and scientific quality is essential for biomedical research progress. In this study, we developed a survey to collect the self-perception of animal care staff (ACS) and laboratory technicians about their involvement in scientific planning and conduct. Participants were contacted to complete an anonymous online questionnaire. We obtained 850 responses, mainly from Europe: 564 from ACS and 286 from laboratory technicians. Job satisfaction was assessed as positive by ACS and laboratory technicians despite the low frequency of culture of care activities and mental health meetings. Both groups expressed their desire to be trained in research planning and conduct; however, regular training was not reported. In addition, the inability to act on animal welfare concerns owing to experimental reasons was reported by both groups. Over half of the participants felt valued and appreciated by the lead scientists or animal facility manager; however, it is not clear how they are acknowledged, as their names on the authors list or in the manuscript acknowledgments are barely included. Our results indicated that involvement of ACS and laboratory technicians in planning and conducting studies would improve their understanding of how experiments are done, and therefore communication processes, work satisfaction, animal welfare, and scientific quality. Finally, we provided recommendations to improve the engagement of ACS and laboratory technicians in discussions about animal research planning and conduct.","lang":"eng"},{"text":"La participation de personnel non-scientifique aux discussions sur le bien-être animal et la qualité scientifique est essentielle aux progrès la recherche biomédicale. Dans cette étude, nous avons développé une enquête pour recueillir l'auto-perception du personnel chargé des soins prodigués aux animaux (PCSA) et des techniciens de laboratoire (TL) sur leur implication dans la planification et la conduite scientifiques. Les participants ont été contactés pour remplir un questionnaire anonyme en ligne. Nous avons obtenu 850 réponses, principalement en Europe : 564 provenant de PCSA et 286 de TL. La satisfaction au travail a été évaluée comme positive par le PCSA et les TL malgré la faible fréquence d’activités sur la culture des soins et de réunions concernant la santé mentale. Bien que les deux groupes aient exprimé leur désir d'être formés à la planification et à la conduite de la recherche, aucune formation réelle régulière n'a été signalée. De plus, l'incapacité d'agir sur les préoccupations relatives au bien-être animal pour des raisons expérimentales a été signalée par les deux groupes. Plus de la moitié des participants se sont sentis valorisés et appréciés par les scientifiques principaux ou le gestionnaire de l’installation animale mais on ne sait pas clairement comment ils sont reconnus, car leurs noms sur la liste des auteurs ou dans les remerciements sont à peine inclus dans la documentation. Nos résultats ont indiqué que la participation du PCSA et des TL à la planification et à la conduite des études améliorerait leur compréhension de la façon dont les expériences sont effectuées et, par conséquent, les processus de communication, leur satisfaction au travail ainsi que le bien-être animal et la qualité scientifique. Enfin, nous avons formulé des recommandations pour améliorer la participation du PCSA et des TL aux discussions sur la planification et la conduite de la recherche animale.","lang":"fre"},{"text":"Die Einbeziehung von nichtwissenschaftlichem Personal in Diskussionen über Tierschutz und wissenschaftliche Qualität ist für Fortschritte in biomedizinischer Forschung von entscheidender Bedeutung. In dieser Studie haben wir eine Umfrage entwickelt, um die Selbsteinschätzung von Tierpflegern (ACS) und Labortechnikern (LT) hinsichtlich ihrer Beteiligung an der wissenschaftlichen Planung und Durchführung zu erfassen. Die Teilnehmer wurden gebeten, einen anonymen Online-Fragebogen auszufüllen. Wir erhielten 850 Rückmeldungen, hauptsächlich aus Europa: 564 von ACS und 286 von LT. Die Arbeitszufriedenheit wurde von ACS und LT trotz der geringen Häufigkeit von Pflegeaktivitäten und Treffen zum Thema psychische Gesundheit als positiv bewertet. Beide Gruppen äußerten den Wunsch, in der Forschungsplanung und -durchführung geschult zu werden, doch regelmäßig stattfindende Schulungen wurden nicht berichtet. Außerdem wurde von beiden Gruppen vermeldet, dass sie aus versuchstechnischen Gründen nicht in der Lage waren, auf Tierschutzbedenken zu reagieren. Über die Hälfte der Teilnehmer fühlte sich von den leitenden Wissenschaftlern oder dem Leiter der Tierhaltungseinrichtung geschätzt und anerkannt; es ist jedoch unklar, inwiefern sie wirklich gewürdigt werden, da ihre Namen kaum in der Autorenliste oder in den Danksagungen des Manuskripts aufgeführt sind. Unsere Ergebnisse deuteten darauf hin, dass die Einbeziehung von ACS und LT in die Planung und Durchführung von Studien ihr Verständnis für die Durchführung von Experimenten verbessern würde – und damit auch Kommunikationsprozesse, Arbeitszufriedenheit, Tierwohl und wissenschaftliche Qualität. Abschließend gaben wir Empfehlungen zur Verbesserung der Einbeziehung von ACS und LT in Diskussionen über die Planung und Durchführung von Tierversuchen.","lang":"ger"},{"lang":"spa","text":"La participación del personal no científico en los debates sobre el bienestar animal y la calidad científica es fundamental para el avance de la investigación biomédica. En este estudio, desarrollamos una encuesta para recoger la autopercepción del personal encargado del cuidado de los animales (ACS) y de los técnicos de laboratorio (LT) sobre su implicación en la planificación y la realización científicas. Se contactó con los participantes para que cumplimentaran un cuestionario anónimo en línea. Obtuvimos 850 respuestas, principalmente de Europa: 564 de ACS y 286 de LT. La satisfacción laboral fue evaluada como positiva por ACS y técnicos de laboratorio a pesar de la baja frecuencia de actividades de cultura del cuidado y reuniones sobre bienestar mental. Ambos grupos expresaron su deseo de recibir formación en planificación y realización de investigaciones, sin embargo, no se informó sobre una formación regular. Asimismo, ambos grupos señalaron la incapacidad de actuar ante las preocupaciones sobre el bienestar animal por motivos experimentales. Más de la mitad de los participantes se sintieron valorados y apreciados por los científicos principales o el responsable de las instalaciones de animales; sin embargo, no está claro cómo se les reconoce, ya que apenas se incluyen sus nombres en la lista de autores o en los agradecimientos del manuscrito. Nuestros resultados indicaron que la participación de los ACS y los LT en la planificación y realización de los estudios mejoraría su comprensión de cómo se hacen los experimentos y, por tanto, los procesos de comunicación, la satisfacción laboral, el bienestar animal y la calidad científica. Finalmente, proporcionamos recomendaciones para mejorar el compromiso de la AEC y la LT en los debates sobre la planificación y la realización de investigaciones con animales."}],"language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"Yes (in subscription journal)","date_updated":"2026-04-28T12:22:17Z","type":"journal_article","publication":"Laboratory Animals","scopus_import":"1","author":[{"first_name":"Fernando","last_name":"Gonzalez-Uarquin","full_name":"Gonzalez-Uarquin, Fernando"},{"last_name":"Jirkof","first_name":"Paulin","full_name":"Jirkof, Paulin"},{"full_name":"Bert, Bettina","first_name":"Bettina","last_name":"Bert"},{"full_name":"Hawkins, Penny","last_name":"Hawkins","first_name":"Penny"},{"full_name":"Angelovski, Ljupco","first_name":"Ljupco","last_name":"Angelovski"},{"full_name":"Baumgart, Jan","last_name":"Baumgart","first_name":"Jan"},{"full_name":"Baumgart, Nadine","last_name":"Baumgart","first_name":"Nadine"},{"first_name":"Özge S.","last_name":"Cevik","full_name":"Cevik, Özge S."},{"last_name":"Franco","first_name":"Nuno H.","full_name":"Franco, Nuno H."},{"first_name":"Erdal","last_name":"Horata","full_name":"Horata, Erdal"},{"full_name":"Kaura, Rohish","first_name":"Rohish","last_name":"Kaura"},{"full_name":"Neuhaus, Winfried","first_name":"Winfried","last_name":"Neuhaus"},{"last_name":"Riso","first_name":"Brigida","full_name":"Riso, Brigida"},{"first_name":"Adrian J.","last_name":"Smith","full_name":"Smith, Adrian J."},{"full_name":"Sotiropoulos, Athanassia","first_name":"Athanassia","last_name":"Sotiropoulos"},{"last_name":"Vitale","first_name":"Augusto","full_name":"Vitale, Augusto"},{"full_name":"Schober, Sophie","id":"80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8","last_name":"Schober","first_name":"Sophie"}],"OA_place":"publisher","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We deeply acknowledge all the animal care staff and laboratory technicians who participated in this study! We acknowledge Working Groups 1 and 4 from COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by COST (European Cooperation in Science and Technology) for their feedback and support. We also acknowledge Aoife Milford for her comments and contributions to the final draft of the manuscript.\r\nThis publication was based on work from the COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by COST (European Cooperation in Science and Technology).","publisher":"SAGE Publications","citation":{"mla":"Gonzalez-Uarquin, Fernando, et al. “Building Bridges: Involvement of Animal Care Staff and Laboratory Technicians in Experimental Planning and Conduct of Animal Studies for Better Job Satisfaction and Science.” Laboratory Animals, SAGE Publications, 2026, doi:10.1177/00236772251400976.","short":"F. Gonzalez-Uarquin, P. Jirkof, B. Bert, P. Hawkins, L. Angelovski, J. Baumgart, N. Baumgart, Ö.S. Cevik, N.H. Franco, E. Horata, R. Kaura, W. Neuhaus, B. Riso, A.J. Smith, A. Sotiropoulos, A. Vitale, S. Schober, Laboratory Animals (2026).","ista":"Gonzalez-Uarquin F, Jirkof P, Bert B, Hawkins P, Angelovski L, Baumgart J, Baumgart N, Cevik ÖS, Franco NH, Horata E, Kaura R, Neuhaus W, Riso B, Smith AJ, Sotiropoulos A, Vitale A, Schober S. 2026. Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science. Laboratory Animals.","chicago":"Gonzalez-Uarquin, Fernando, Paulin Jirkof, Bettina Bert, Penny Hawkins, Ljupco Angelovski, Jan Baumgart, Nadine Baumgart, et al. “Building Bridges: Involvement of Animal Care Staff and Laboratory Technicians in Experimental Planning and Conduct of Animal Studies for Better Job Satisfaction and Science.” Laboratory Animals. SAGE Publications, 2026. https://doi.org/10.1177/00236772251400976.","ieee":"F. Gonzalez-Uarquin et al., “Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science,” Laboratory Animals. SAGE Publications, 2026.","ama":"Gonzalez-Uarquin F, Jirkof P, Bert B, et al. Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science. Laboratory Animals. 2026. doi:10.1177/00236772251400976","apa":"Gonzalez-Uarquin, F., Jirkof, P., Bert, B., Hawkins, P., Angelovski, L., Baumgart, J., … Schober, S. (2026). Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science. Laboratory Animals. SAGE Publications. https://doi.org/10.1177/00236772251400976"},"date_created":"2026-04-26T22:01:47Z","department":[{"_id":"PreCl"}],"status":"public","month":"04","date_published":"2026-04-14T00:00:00Z","quality_controlled":"1","publication_identifier":{"eissn":["1758-1117"],"issn":["0023-6772"]},"_id":"21767"},{"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","month":"02","publisher":"EDP Sciences","citation":{"ieee":"A.-A. Cristea et al., “A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant,” Astronomy & Astrophysics, vol. 706. EDP Sciences, 2026.","apa":"Cristea, A.-A., Caiazzo, I., Cunningham, T., Raymond, J. C., Vennes, S., Kawka, A., … Bellm, E. C. (2026). A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202556432","ama":"Cristea A-A, Caiazzo I, Cunningham T, et al. A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant. Astronomy & Astrophysics. 2026;706. doi:10.1051/0004-6361/202556432","chicago":"Cristea, Andrei-Alexandru, Ilaria Caiazzo, Tim Cunningham, John C. Raymond, Stephane Vennes, Adela Kawka, Aayush A Desai, et al. “A Half Ring of Ionized Circumstellar Material Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202556432.","ista":"Cristea A-A, Caiazzo I, Cunningham T, Raymond JC, Vennes S, Kawka A, Desai AA, Miller DR, Hermes JJ, Fuller J, Heyl J, van Roestel J, Burdge KB, Rodriguez AC, Pelisoli I, Gänsicke BT, Szkody P, Kenyon SJ, Vanderbosch Z, Drake A, Ferrario L, Wickramasinghe D, Karambelkar VR, Justham S, Pakmor R, El-Badry K, Prince T, Kulkarni SR, Graham MJ, Masci FJ, Groom SL, Purdum J, Dekany R, Bellm EC. 2026. A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant. Astronomy & Astrophysics. 706, A188.","mla":"Cristea, Andrei-Alexandru, et al. “A Half Ring of Ionized Circumstellar Material Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” Astronomy & Astrophysics, vol. 706, A188, EDP Sciences, 2026, doi:10.1051/0004-6361/202556432.","short":"A.-A. Cristea, I. Caiazzo, T. Cunningham, J.C. Raymond, S. Vennes, A. Kawka, A.A. Desai, D.R. Miller, J.J. Hermes, J. Fuller, J. Heyl, J. van Roestel, K.B. Burdge, A.C. Rodriguez, I. Pelisoli, B.T. Gänsicke, P. Szkody, S.J. Kenyon, Z. Vanderbosch, A. Drake, L. Ferrario, D. Wickramasinghe, V.R. Karambelkar, S. Justham, R. Pakmor, K. El-Badry, T. Prince, S.R. Kulkarni, M.J. Graham, F.J. Masci, S.L. Groom, J. Purdum, R. Dekany, E.C. Bellm, Astronomy & Astrophysics 706 (2026)."},"department":[{"_id":"IlCa"},{"_id":"GradSch"}],"date_created":"2026-02-17T08:12:05Z","publication_identifier":{"issn":["0004-6361"],"eissn":["1432-0746"]},"intvolume":" 706","_id":"21274","date_published":"2026-02-10T00:00:00Z","quality_controlled":"1","related_material":{"link":[{"description":"News on ISTA website","relation":"press_release","url":"https://ista.ac.at/en/news/twos-company-new-class-of-star-remnants/"}]},"oa_version":"Published Version","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","author":[{"first_name":"Andrei-Alexandru","last_name":"Cristea","id":"4d500bea-31f8-11ee-a48d-d4904fb363c7","full_name":"Cristea, Andrei-Alexandru"},{"first_name":"Ilaria","last_name":"Caiazzo","full_name":"Caiazzo, Ilaria","orcid":"0000-0002-4770-5388","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d"},{"full_name":"Cunningham, Tim","last_name":"Cunningham","first_name":"Tim"},{"full_name":"Raymond, John C.","last_name":"Raymond","first_name":"John C."},{"full_name":"Vennes, Stephane","first_name":"Stephane","last_name":"Vennes"},{"first_name":"Adela","last_name":"Kawka","full_name":"Kawka, Adela"},{"last_name":"Desai","first_name":"Aayush A","id":"502cfd30-32c1-11ee-a9a4-d8dad5c6739e","full_name":"Desai, Aayush A"},{"first_name":"David R.","last_name":"Miller","full_name":"Miller, David R."},{"first_name":"J. J.","last_name":"Hermes","full_name":"Hermes, J. J."},{"full_name":"Fuller, Jim","first_name":"Jim","last_name":"Fuller"},{"last_name":"Heyl","first_name":"Jeremy","full_name":"Heyl, Jeremy"},{"full_name":"van Roestel, Jan","last_name":"van Roestel","first_name":"Jan"},{"last_name":"Burdge","first_name":"Kevin B.","full_name":"Burdge, Kevin B."},{"full_name":"Rodriguez, Antonio C.","first_name":"Antonio C.","last_name":"Rodriguez"},{"full_name":"Pelisoli, Ingrid","last_name":"Pelisoli","first_name":"Ingrid"},{"full_name":"Gänsicke, Boris T.","last_name":"Gänsicke","first_name":"Boris T."},{"first_name":"Paula","last_name":"Szkody","full_name":"Szkody, Paula"},{"full_name":"Kenyon, Scott J.","first_name":"Scott J.","last_name":"Kenyon"},{"first_name":"Zach","last_name":"Vanderbosch","full_name":"Vanderbosch, Zach"},{"full_name":"Drake, Andrew","first_name":"Andrew","last_name":"Drake"},{"first_name":"Lilia","last_name":"Ferrario","full_name":"Ferrario, Lilia"},{"full_name":"Wickramasinghe, Dayal","last_name":"Wickramasinghe","first_name":"Dayal"},{"full_name":"Karambelkar, Viraj R.","last_name":"Karambelkar","first_name":"Viraj R."},{"last_name":"Justham","first_name":"Stephen","full_name":"Justham, Stephen"},{"last_name":"Pakmor","first_name":"Ruediger","full_name":"Pakmor, Ruediger"},{"last_name":"El-Badry","first_name":"Kareem","full_name":"El-Badry, Kareem"},{"full_name":"Prince, Thomas","last_name":"Prince","first_name":"Thomas"},{"full_name":"Kulkarni, S. R.","last_name":"Kulkarni","first_name":"S. R."},{"last_name":"Graham","first_name":"Matthew J.","full_name":"Graham, Matthew J."},{"last_name":"Masci","first_name":"Frank J.","full_name":"Masci, Frank J."},{"full_name":"Groom, Steven L.","first_name":"Steven L.","last_name":"Groom"},{"last_name":"Purdum","first_name":"Josiah","full_name":"Purdum, Josiah"},{"full_name":"Dekany, Richard","first_name":"Richard","last_name":"Dekany"},{"full_name":"Bellm, Eric C.","last_name":"Bellm","first_name":"Eric C."}],"DOAJ_listed":"1","OA_place":"publisher","has_accepted_license":"1","acknowledgement":"We thank Lynne Hillenbrand and Soumyadeep Bhattacharjee for helpful discussions, and Kishalay De for his help with the WIRC\r\nreduction pipeline. IC was supported by NASA through grants from the Space\r\nTelescope Science Institute, under NASA contracts NASA.22K1813, NAS5-\r\n26555 and NAS5-03127. TC was supported by NASA through the NASA Hubble\r\nFellowship grant HST-HF2-51527.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research\r\nin Astronomy, Inc., for NASA, under contract NAS5-26555. This project has\r\nreceived funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 101020057). This work was based on observations obtained with the\r\nSamuel Oschin Telescope 48-inch and the 60-inch Telescope at the Palomar\r\nObservatory as part of the Zwicky Transient Facility project. ZTF is supported\r\nby the National Science Foundation under Grants No. AST-1440341, AST2034437, and currently Award #2407588. ZTF receives additional funding from\r\nthe ZTF partnership. Current members include Caltech, USA; Caltech/IPAC,\r\nUSA; University of Maryland, USA; University of California, Berkeley, USA;\r\nUniversity of Wisconsin at Milwaukee, USA; Cornell University, USA; Drexel\r\nUniversity, USA; University of North Carolina at Chapel Hill, USA; Institute\r\nof Science and Technology, Austria; National Central University, Taiwan, and\r\nOKC, University of Stockholm, Sweden. Operations are conducted by Caltech’s\r\nOptical Observatory (COO), Caltech/IPAC, and the University of Washington at\r\nSeattle, USA. This work has made use of data from the European Space Agency\r\n(ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by\r\nthe Gaia Data Processing and Analysis Consortium (DPAC, https://www.\r\ncosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. The Pan-STARRS1 Surveys (PS1)\r\nand the PS1 public science archive have been made possible through contributions by the Institute for Astronomy, the University of Hawaii, the PanSTARRS Project Office, the Max-Planck Society and its participating institutes, the Max Planck Institute for Astronomy, Heidelberg and the Max Planck\r\nInstitute for Extraterrestrial Physics, Garching, The Johns Hopkins University,\r\nDurham University, the University of Edinburgh, the Queen’s University Belfast,\r\nthe Harvard-Smithsonian Center for Astrophysics, the Las Cumbres Observatory Global Telescope Network Incorporated, the National Central University of Taiwan, the Space Telescope Science Institute, the National Aeronautics and Space Administration under Grant No. NNX08AR22G issued through\r\nthe Planetary Science Division of the NASA Science Mission Directorate, the\r\nNational Science Foundation Grant No. AST–1238877, the University of Maryland, Eotvos Lorand University (ELTE), the Los Alamos National Laboratory,\r\nand the Gordon and Betty Moore Foundation. This work made use of Astropy\r\n(http://www.astropy.org): a community-developed core Python package\r\nand an ecosystem of tools and resources for astronomy (Astropy Collaboration\r\n2013, 2018, 2022).","file":[{"date_updated":"2026-02-23T12:04:37Z","file_id":"21350","content_type":"application/pdf","creator":"dernst","relation":"main_file","access_level":"open_access","date_created":"2026-02-23T12:04:37Z","file_size":5352853,"checksum":"229b688e6e78cab5bb8e2bac366d1575","success":1,"file_name":"2026_AstronomyAstrophysics_Cristea.pdf"}],"article_type":"original","article_processing_charge":"Yes","ddc":["520"],"PlanS_conform":"1","date_updated":"2026-04-28T12:01:21Z","publication":"Astronomy & Astrophysics","type":"journal_article","publication_status":"published","doi":"10.1051/0004-6361/202556432","file_date_updated":"2026-02-23T12:04:37Z","corr_author":"1","abstract":[{"text":"Many white dwarfs are observed in compact double white dwarf binaries, and through the emission of gravitational waves, a large fraction are destined to merge. The merger remnants that do not explode in a Type Ia supernova are expected to initially be rapidly rotating and highly magnetized. In this work, we present our discovery of the variable white dwarf ZTF J200832.79+444939.67, hereafter ZTF J2008+4449, as a likely merger remnant showing signs of circumstellar material without a stellar or substellar companion. The nature of ZTF J2008+4449 as a merger remnant is supported by its physical properties: it is hot (35 500 ± 300 K) and massive (1.12 ± 0.03 M\r\n ⊙\r\n ), rapidly rotating with a period of ≈6.6 minutes, and likely possesses exceptionally strong magnetic fields (∼400−600 MG) at its surface. Remarkably, we detect a significant period derivative of (1.80 ± 0.09)×10\r\n −12\r\n s/s, indicating that the white dwarf is spinning down, and a soft X-ray emission that is inconsistent with photospheric emission. As the presence of a mass-transferring stellar or brown dwarf companion is excluded by infrared photometry, the detected spin-down and X-ray emission could be tell-tale signs of a magnetically driven wind or of interaction with circumstellar material, possibly originating from the fallback of gravitationally bound merger ejecta or from the tidal disruption of a planetary object. We also detect Balmer emission, which requires the presence of ionized hydrogen in the vicinity of the white dwarf, showing Doppler shifts as high as ≈2000 km s\r\n −1\r\n . The unusual variability of the Balmer emission on the spin period of the white dwarf is consistent with the trapping of a half ring of ionized gas in the magnetosphere of the white dwarf.\r\n ","lang":"eng"}],"article_number":"A188","language":[{"iso":"eng"}],"title":"A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant","volume":706,"year":"2026","day":"10","OA_type":"gold","oa":1},{"file":[{"file_name":"2026_Nature_Grosjean.pdf","success":1,"checksum":"dafef9ed575b44be4263e948a47ae056","file_size":12245694,"date_created":"2026-03-24T06:57:08Z","access_level":"open_access","relation":"main_file","creator":"dernst","content_type":"application/pdf","date_updated":"2026-03-24T06:57:08Z","file_id":"21494"}],"acknowledgement":"This project has received support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 949120) and from the Marie Skłodowska-Curie programme (grant agreement no. 754411). We acknowledge the state of Lower Austria and the European Regional Development Fund under grant no. WST3-F-542638/004-2021. N.M. acknowledges support from grant Fondecyt 1221597. G.G. is a Serra Húnter fellow. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing facility and Lab Support Facility. We thank the Modic group for the use of the Laue camera, T. Zauner for the photography of the experimental set-up and R. Möller for insightful discussions. Open access funding provided by Institute of Science and Technology (IST Austria).","has_accepted_license":"1","external_id":{"pmid":["41851325"]},"author":[{"last_name":"Grosjean","first_name":"Galien M","id":"0C5FDA4A-9CF6-11E9-8939-FF05E6697425","full_name":"Grosjean, Galien M","orcid":"0000-0001-5154-417X"},{"first_name":"Markus","last_name":"Ostermann","full_name":"Ostermann, Markus"},{"first_name":"Markus","last_name":"Sauer","full_name":"Sauer, Markus"},{"full_name":"Hahn, Michael","first_name":"Michael","last_name":"Hahn"},{"first_name":"Christian M.","last_name":"Pichler","full_name":"Pichler, Christian M."},{"last_name":"Fahrnberger","first_name":"Florian","full_name":"Fahrnberger, Florian"},{"full_name":"Pertl, Felix","id":"6313aec0-15b2-11ec-abd3-ed67d16139af","orcid":"0000-0003-0463-5794","last_name":"Pertl","first_name":"Felix"},{"orcid":"0000-0001-7597-043X","full_name":"Balazs, Daniel","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","last_name":"Balazs","first_name":"Daniel"},{"first_name":"Mason M.","last_name":"Link","full_name":"Link, Mason M."},{"full_name":"Kim, Seong H.","last_name":"Kim","first_name":"Seong H."},{"full_name":"Schrader, Devin L.","last_name":"Schrader","first_name":"Devin L."},{"last_name":"Blanco","first_name":"Adriana","full_name":"Blanco, Adriana"},{"first_name":"Francisco","last_name":"Gracia","full_name":"Gracia, Francisco"},{"first_name":"Nicolás","last_name":"Mujica","full_name":"Mujica, Nicolás"},{"first_name":"Scott R","last_name":"Waitukaitis","orcid":"0000-0002-2299-3176","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","full_name":"Waitukaitis, Scott R"}],"pmid":1,"OA_place":"publisher","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","related_material":{"link":[{"description":"News on ISTA website","relation":"press_release","url":"https://ista.ac.at/en/news/colliding-dust-and-the-sparks-of-creation/"}]},"oa_version":"Published Version","date_published":"2026-03-18T00:00:00Z","quality_controlled":"1","project":[{"name":"Tribocharge: a multi-scale approach to an enduring problem in physics","_id":"0aa60e99-070f-11eb-9043-a6de6bdc3afa","call_identifier":"H2020","grant_number":"949120"},{"grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"_id":"21485","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"issue":"8106","intvolume":" 651","citation":{"chicago":"Grosjean, Galien M, Markus Ostermann, Markus Sauer, Michael Hahn, Christian M. Pichler, Florian Fahrnberger, Felix Pertl, et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-025-10088-w.","ista":"Grosjean GM, Ostermann M, Sauer M, Hahn M, Pichler CM, Fahrnberger F, Pertl F, Balazs D, Link MM, Kim SH, Schrader DL, Blanco A, Gracia F, Mujica N, Waitukaitis SR. 2026. Adventitious carbon breaks symmetry in oxide contact electrification. Nature. 651(8106), 626–631.","short":"G.M. Grosjean, M. Ostermann, M. Sauer, M. Hahn, C.M. Pichler, F. Fahrnberger, F. Pertl, D. Balazs, M.M. Link, S.H. Kim, D.L. Schrader, A. Blanco, F. Gracia, N. Mujica, S.R. Waitukaitis, Nature 651 (2026) 626–631.","mla":"Grosjean, Galien M., et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” Nature, vol. 651, no. 8106, Springer Nature, 2026, pp. 626–31, doi:10.1038/s41586-025-10088-w.","ama":"Grosjean GM, Ostermann M, Sauer M, et al. Adventitious carbon breaks symmetry in oxide contact electrification. Nature. 2026;651(8106):626-631. doi:10.1038/s41586-025-10088-w","ieee":"G. M. Grosjean et al., “Adventitious carbon breaks symmetry in oxide contact electrification,” Nature, vol. 651, no. 8106. Springer Nature, pp. 626–631, 2026.","apa":"Grosjean, G. M., Ostermann, M., Sauer, M., Hahn, M., Pichler, C. M., Fahrnberger, F., … Waitukaitis, S. R. (2026). Adventitious carbon breaks symmetry in oxide contact electrification. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-10088-w"},"publisher":"Springer Nature","department":[{"_id":"ScWa"},{"_id":"GradSch"},{"_id":"LifeSc"}],"date_created":"2026-03-23T15:04:00Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"page":"626-631","month":"03","status":"public","year":"2026","volume":651,"title":"Adventitious carbon breaks symmetry in oxide contact electrification","oa":1,"OA_type":"hybrid","day":"18","corr_author":"1","abstract":[{"lang":"eng","text":"Insulating oxides are among the most abundant solid materials in the universe1,2,3. Of the many ways in which they influence natural phenomena, perhaps the most consequential is their capacity to transfer electrical charge during contact4,5,6,7,8,9,10—which occurs even between samples of the same oxide—yet the symmetry-breaking parameter that causes this remains unidentified11,12. Here we show that adventitious carbonaceous molecules adsorbed from the environment are the symmetry-breaking factor in same-material oxide contact electrification (CE). We use acoustic levitation to measure charge exchange between a sphere and a plate composed of identical amorphous silicon dioxide (SiO2). Although charging polarity is random for co-prepared samples, we control it with baking or plasma treatment. Observing the charge-exchange relaxation afterwards, we see dynamics over a timescale of hours and connect this directly to the presence of adventitious carbon with time-of-flight mass spectrometry, low-energy ion scattering and infrared spectroscopy. Going further, we confirm that adventitious carbon can even determine charge exchange among different oxides. Our results identify the symmetry-breaking parameter that causes insulating oxides to exchange charge in settings ranging from desert sands4 to volcanic plumes5,6, while simultaneously highlighting an overlooked factor in CE more broadly."}],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"language":[{"iso":"eng"}],"ec_funded":1,"file_date_updated":"2026-03-24T06:57:08Z","publication_status":"published","doi":"10.1038/s41586-025-10088-w","publication":"Nature","type":"journal_article","date_updated":"2026-04-28T12:06:01Z","PlanS_conform":"1","ddc":["540"],"article_type":"original","article_processing_charge":"Yes (via OA deal)"},{"related_material":{"link":[{"url":"https://ista.ac.at/en/news/geometry-shapes-life/","relation":"research_data","description":"News on ISTA website"}]},"oa_version":"Published Version","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oaworkid":1,"OA_place":"publisher","author":[{"first_name":"Nikhil","last_name":"Mishra","id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","orcid":"0000-0002-6425-5788","full_name":"Mishra, Nikhil"},{"last_name":"Li","first_name":"Yuting I","full_name":"Li, Yuting I","id":"ee7a5ca8-8b71-11ed-b662-b3341c05b7eb"},{"orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","first_name":"Edouard B","last_name":"Hannezo"},{"first_name":"Carl-Philipp J","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"}],"external_id":{"oaworkid":["W7118187193"]},"acknowledgement":"We thank N. Petridou (EMBL) for sharing results before publication. N.M. was supported by funding from the European Union’s Horizon 2020 programme under the Marie Skłodowska-Curie COFUND Actions ISTplus grant agreement number 754411. Y.I.L. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement number 101034413. The research was supported by funding to C.-P.H. from the NOMIS Foundation, Project ID 1.844. We would like to thank past and present members of the Heisenberg and Hannezo groups for discussions, particularly S. Shamipour, V. Doddihal, M. Jovic, N. Hino, F. N. Arslan, R. Kobylinska and C. Camelo for feedback on the draft manuscript. This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria through resources provided by the Aquatics Facility, Imaging & Optics Facility (IOF), Scientific Computing (SciComp) facility and Lab Support Facility (LSF). Open access funding provided by Institute of Science and Technology (IST Austria).","has_accepted_license":"1","file":[{"checksum":"0ab7ac2fbcb61a364dba57152db64ed7","success":1,"file_size":7335694,"file_name":"2026_NaturePhysics_Mishra.pdf","date_created":"2026-01-21T08:21:11Z","relation":"main_file","access_level":"open_access","creator":"dernst","content_type":"application/pdf","file_id":"21026","date_updated":"2026-01-21T08:21:11Z"}],"status":"public","month":"01","page":"139-150","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_created":"2026-01-20T10:12:19Z","department":[{"_id":"EdHa"},{"_id":"CaHe"}],"citation":{"ista":"Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. 2026. Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo. Nature Physics. 22, 139–150.","mla":"Mishra, Nikhil, et al. “Geometry-Driven Asymmetric Cell Divisions Pattern Cell Cycles and Zygotic Genome Activation in the Zebrafish Embryo.” Nature Physics, vol. 22, Springer Nature, 2026, pp. 139–50, doi:10.1038/s41567-025-03122-1.","short":"N. Mishra, Y.I. Li, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 22 (2026) 139–150.","chicago":"Mishra, Nikhil, Yuting I Li, Edouard B Hannezo, and Carl-Philipp J Heisenberg. “Geometry-Driven Asymmetric Cell Divisions Pattern Cell Cycles and Zygotic Genome Activation in the Zebrafish Embryo.” Nature Physics. Springer Nature, 2026. https://doi.org/10.1038/s41567-025-03122-1.","apa":"Mishra, N., Li, Y. I., Hannezo, E. B., & Heisenberg, C.-P. J. (2026). Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-025-03122-1","ieee":"N. Mishra, Y. I. Li, E. B. Hannezo, and C.-P. J. Heisenberg, “Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo,” Nature Physics, vol. 22. Springer Nature, pp. 139–150, 2026.","ama":"Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo. Nature Physics. 2026;22:139-150. doi:10.1038/s41567-025-03122-1"},"publisher":"Springer Nature","intvolume":" 22","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"],"issnl":[" 1745-2473"]},"_id":"21015","quality_controlled":"1","project":[{"name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411"},{"grant_number":"101034413","call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program"},{"name":"Cytoplasmic self-organization into cell-like compartments as a common guiding principle in early animal development","_id":"917c023a-16d5-11f0-9cad-eb5cafc52090"}],"date_published":"2026-01-05T00:00:00Z","doi":"10.1038/s41567-025-03122-1","publication_status":"published","file_date_updated":"2026-01-21T08:21:11Z","ec_funded":1,"language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"corr_author":"1","abstract":[{"lang":"eng","text":"Early embryo geometry is one of the most invariant species-specific traits, yet its role in ensuring developmental reproducibility and robustness remains underexplored. Here we show that in zebrafish, the geometry of the fertilized egg—specifically its curvature and volume—serves as a critical initial condition triggering a cascade of events that influence development. The embryo geometry guides patterned asymmetric cell divisions in the blastoderm, generating radial gradients of cell volume and nucleocytoplasmic ratio. These gradients generate mitotic phase waves, with the nucleocytoplasmic ratio determining individual cell cycle periods independently of other cells. We demonstrate that reducing cell autonomy reshapes these waves, emphasizing the instructive role of geometry-derived volume patterns in setting the intrinsic period of the cell cycle oscillator. In addition to organizing cell cycles, early embryo geometry spatially patterns zygotic genome activation at the midblastula transition, a key step in establishing embryonic autonomy. Disrupting the embryo shape alters the zygotic genome activation pattern and causes ectopic germ layer specification, underscoring the developmental significance of geometry. Together, our findings reveal a symmetry-breaking function of early embryo geometry in coordinating cell cycle and transcriptional patterning."}],"OA_type":"hybrid","day":"05","oa":1,"title":"Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo","volume":22,"year":"2026","article_processing_charge":"Yes (via OA deal)","article_type":"original","ddc":["570"],"scopus_import":"1","date_updated":"2026-04-28T12:55:30Z","PlanS_conform":"1","publication":"Nature Physics","type":"journal_article"},{"file":[{"file_id":"21390","date_updated":"2026-03-02T14:27:56Z","content_type":"application/pdf","creator":"dernst","relation":"main_file","access_level":"open_access","date_created":"2026-03-02T14:27:56Z","success":1,"file_size":2570918,"checksum":"dd7a98de892d0b5abefca7e290ca0f77","file_name":"2026_NatureComm_Rak.pdf"}],"acknowledgement":"We are grateful to A. G. Volosniev for the valuable discussions. We thank D. Milius for the assistance with microscopy. D. R. would like to thank F. Filakovský and T. Čuchráč for the valuable discussions. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF) and the Miba Machine Shop Facility (MS).","has_accepted_license":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","related_material":{"link":[{"url":"https://ista.ac.at/en/news/explaining-next-generation-solar-cells/","relation":"press_release","description":"News on ISTA website"}]},"oa_version":"Published Version","DOAJ_listed":"1","external_id":{"pmid":["41698893"]},"pmid":1,"author":[{"last_name":"Rak","first_name":"Dmytro","full_name":"Rak, Dmytro","id":"70313b46-47c2-11ec-9e88-cd79101918fe"},{"first_name":"Dusan","last_name":"Lorenc","id":"40D8A3E6-F248-11E8-B48F-1D18A9856A87","full_name":"Lorenc, Dusan"},{"id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","full_name":"Balazs, Daniel","orcid":"0000-0001-7597-043X","last_name":"Balazs","first_name":"Daniel"},{"last_name":"Zhumekenov","first_name":"Ayan A.","full_name":"Zhumekenov, Ayan A."},{"first_name":"Osman M.","last_name":"Bakr","full_name":"Bakr, Osman M."},{"last_name":"Alpichshev","first_name":"Zhanybek","full_name":"Alpichshev, Zhanybek","id":"45E67A2A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7183-5203"}],"OA_place":"publisher","_id":"21382","publication_identifier":{"eissn":["2041-1723"]},"intvolume":" 17","date_published":"2026-02-16T00:00:00Z","quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"month":"02","status":"public","citation":{"ista":"Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. 2026. Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. 17, 946.","short":"D. Rak, D. Lorenc, D. Balazs, A.A. Zhumekenov, O.M. Bakr, Z. Alpichshev, Nature Communications 17 (2026).","mla":"Rak, Dmytro, et al. “Flexoelectric Domain Walls Enable Charge Separation and Transport in Cubic Perovskites.” Nature Communications, vol. 17, 946, Springer Nature, 2026, doi:10.1038/s41467-026-68660-5.","chicago":"Rak, Dmytro, Dusan Lorenc, Daniel Balazs, Ayan A. Zhumekenov, Osman M. Bakr, and Zhanybek Alpichshev. “Flexoelectric Domain Walls Enable Charge Separation and Transport in Cubic Perovskites.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-68660-5.","ieee":"D. Rak, D. Lorenc, D. Balazs, A. A. Zhumekenov, O. M. Bakr, and Z. Alpichshev, “Flexoelectric domain walls enable charge separation and transport in cubic perovskites,” Nature Communications, vol. 17. Springer Nature, 2026.","ama":"Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. 2026;17. doi:10.1038/s41467-026-68660-5","apa":"Rak, D., Lorenc, D., Balazs, D., Zhumekenov, A. A., Bakr, O. M., & Alpichshev, Z. (2026). Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-68660-5"},"publisher":"Springer Nature","date_created":"2026-03-02T10:06:58Z","department":[{"_id":"ZhAl"},{"_id":"LifeSc"}],"corr_author":"1","abstract":[{"lang":"eng","text":"The exceptional energy-harvesting efficiency of lead-halide perovskites arises from unusually long photocarrier diffusion lengths and recombination lifetimes that persist even in defect-rich, solution-grown samples. Paradoxically, perovskites are also known for having very short exciton decay times. Here, we resolve this apparent contradiction by showing that key optoelectronic properties of perovskites can be explained by localized flexoelectric polarization confined to interfaces between domains of spontaneous strain. Using birefringence imaging, electrochemical staining, and zero-bias photocurrent measurements, we visualize the domain structure and directly probe the associated internal fields in nominally cubic single crystals of methylammonium lead bromide. We demonstrate that localized flexoelectric fields spatially separate electrons and holes to opposite sides of domain walls, exponentially suppressing recombination. Domain walls thus act as efficient mesoscopic transport channels for long-lived photocarriers, microscopically linking structural heterogeneity to charge transport and offering mechanistically informed design principles for perovskite solar-energy technologies."}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"M-Shop"}],"language":[{"iso":"eng"}],"article_number":"946","year":"2026","volume":17,"title":"Flexoelectric domain walls enable charge separation and transport in cubic perovskites","oa":1,"day":"16","OA_type":"gold","publication_status":"published","doi":"10.1038/s41467-026-68660-5","file_date_updated":"2026-03-02T14:27:56Z","scopus_import":"1","ddc":["530"],"publication":"Nature Communications","type":"journal_article","PlanS_conform":"1","date_updated":"2026-04-28T12:12:46Z","article_type":"original","article_processing_charge":"Yes"},{"title":"Joint modeling of whole-genome sequencing data for human height via approximate message passing","year":"2026","day":"18","OA_type":"gold","oa":1,"abstract":[{"text":"Human height is a model for the genetic analysis of complex traits, and recent studies suggest the presence of thousands of common genetic variant associations and hundreds of low-frequency/rare variants. Here, we develop a new algorithmic paradigm based on approximate message passing (genomic vector approximate message passing [gVAMP]) for identifying DNA sequence variants associated with complex traits and common diseases in large-scale whole-genome sequencing (WGS) data. We show that gVAMP accurately localizes associations to variants with the correct frequency and position in the DNA, outperforming existing fine-mapping methods in selecting the appropriate genetic variants within WGS data. We then apply gVAMP to jointly model the relationship of tens of millions of WGS variants with human height in hundreds of thousands of UK Biobank individuals. We identify 59 rare variants and gene burden scores alongside many hundreds of DNA regions containing common variant associations and show that understanding the genetic basis of complex traits will require the joint analysis of hundreds of millions of variables measured on millions of people. The polygenic risk scores obtained from gVAMP have high accuracy (including a prediction accuracy of ∼46% for human height) and outperform current methods for downstream tasks such as mixed linear model association testing across 13 UK Biobank traits. In conclusion, gVAMP offers a scalable foundation for a wider range of analyses in WGS data.","lang":"eng"}],"corr_author":"1","language":[{"iso":"eng"}],"article_number":"101162","main_file_link":[{"url":"https://doi.org/10.1016/j.xgen.2026.101162","open_access":"1"}],"publication_status":"epub_ahead","doi":"10.1016/j.xgen.2026.101162","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","date_updated":"2026-04-28T12:08:37Z","type":"journal_article","publication":"Cell Genomics","ddc":["000","570"],"article_type":"original","article_processing_charge":"Yes","acknowledgement":"We thank Malgorzata Borczyk for creating the gene burden scores. We thank Robin Beaumont, Amedeo Roberto Esposito, Gareth Hawkes, Philip Schniter, Matthew Stephens, Pragya Sur, Peter Visscher, Michael Weedon, and Harry Wright for providing valuable suggestions and comments on earlier versions of the work. This project was funded by a Lopez-Loreta Prize to M.M., an SNSF Eccellenza Grant to M.R.R. (PCEGP3-181181), an ERC Starting Grant to M.M. (INF2, project number 101161364), and core funding from ISTA. High-performance computing was supported by the Scientific Service Units (SSU) of ISTA through resources provided by Scientific Computing (SciComp). We would like to acknowledge the participants and investigators of the UK Biobank study. We gratefully acknowledge the All of Us participants for their contributions, without whom this research would not have been possible. We also thank the National Institutes of Health All of Us Research Program for making available the participant data (and/or samples and/or cohort) examined in this study.","has_accepted_license":"1","author":[{"id":"0b77531d-dbcd-11ea-9d1d-a8eee0bf3830","full_name":"Depope, Al","first_name":"Al","last_name":"Depope"},{"full_name":"Bajzik, Jakub","id":"b995e25b-8c4b-11ed-a6d8-f71b7bcd6122","first_name":"Jakub","last_name":"Bajzik"},{"full_name":"Mondelli, Marco","id":"27EB676C-8706-11E9-9510-7717E6697425","orcid":"0000-0002-3242-7020","last_name":"Mondelli","first_name":"Marco"},{"first_name":"Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"}],"DOAJ_listed":"1","OA_place":"publisher","related_material":{"link":[{"relation":"press_release","description":"News on ISTA website","url":"https://ista.ac.at/en/news/big-data-and-human-height/"}]},"oa_version":"Published Version","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2026-02-18T00:00:00Z","project":[{"name":"Prix Lopez-Loretta 2019 - Marco Mondelli","_id":"059876FA-7A3F-11EA-A408-12923DDC885E"},{"grant_number":"101161364","_id":"911e6d1f-16d5-11f0-9cad-c5c68c6a1cdf","name":"Inference in High Dimensions: Light-speed Algorithms and Information Limits"},{"grant_number":"PCEGP3_181181","name":"Improving estimation and prediction of common complex disease risk","_id":"9B8D11D6-BA93-11EA-9121-9846C619BF3A"}],"quality_controlled":"1","publication_identifier":{"eissn":["2666-979X"]},"_id":"21488","citation":{"chicago":"Depope, Al, Jakub Bajzik, Marco Mondelli, and Matthew Richard Robinson. “Joint Modeling of Whole-Genome Sequencing Data for Human Height via Approximate Message Passing.” Cell Genomics. Elsevier, 2026. https://doi.org/10.1016/j.xgen.2026.101162.","short":"A. Depope, J. Bajzik, M. Mondelli, M.R. Robinson, Cell Genomics (2026).","mla":"Depope, Al, et al. “Joint Modeling of Whole-Genome Sequencing Data for Human Height via Approximate Message Passing.” Cell Genomics, 101162, Elsevier, 2026, doi:10.1016/j.xgen.2026.101162.","ista":"Depope A, Bajzik J, Mondelli M, Robinson MR. 2026. Joint modeling of whole-genome sequencing data for human height via approximate message passing. Cell Genomics., 101162.","apa":"Depope, A., Bajzik, J., Mondelli, M., & Robinson, M. R. (2026). Joint modeling of whole-genome sequencing data for human height via approximate message passing. Cell Genomics. Elsevier. https://doi.org/10.1016/j.xgen.2026.101162","ama":"Depope A, Bajzik J, Mondelli M, Robinson MR. Joint modeling of whole-genome sequencing data for human height via approximate message passing. Cell Genomics. 2026. doi:10.1016/j.xgen.2026.101162","ieee":"A. Depope, J. Bajzik, M. Mondelli, and M. R. Robinson, “Joint modeling of whole-genome sequencing data for human height via approximate message passing,” Cell Genomics. Elsevier, 2026."},"publisher":"Elsevier","date_created":"2026-03-23T15:10:03Z","department":[{"_id":"MaMo"},{"_id":"MaRo"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)"},"status":"public","month":"02"},{"scopus_import":"1","date_updated":"2026-04-28T12:41:00Z","type":"journal_article","publication":"Current Opinion in Genetics and Development","article_processing_charge":"Yes (via OA deal)","article_type":"review","language":[{"iso":"eng"}],"article_number":"102472","corr_author":"1","abstract":[{"text":"Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target genes. Decades-long efforts yielded TF-DNA interaction models that predict how strongly an individual TF binds arbitrary DNA sequences and how individual binding events on the CRE combine to affect gene expression. These insights can be synthesized into a global, biophysically realistic, and quantitative genotype-phenotype (GP) map for gene regulation, a ‘holy grail’ for the application of evolutionary theory. A global map provides a rare opportunity to simulate the long-term evolution of regulatory sequences and pose several fundamental questions: How long does it take to evolve CREs de novo? How many non-trivial regulatory functions exist in sequence space? How connected are they? For which regulatory architecture is CRE evolution most rapid and evolvable? In this article, the second of a two-part series, we review the application of evolutionary concepts — epistasis, robustness, evolvability, tunability, plasticity, and bet-hedging — to the evolution of gene regulatory sequences. We then evaluate the potential for a unifying theory for the evolution of regulatory sequences and identify key open challenges.","lang":"eng"}],"OA_type":"hybrid","day":"15","oa":1,"volume":98,"title":"Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges","year":"2026","doi":"10.1016/j.gde.2026.102472","publication_status":"epub_ahead","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.gde.2026.102472"}],"publication_identifier":{"issn":["0959-437X"],"eissn":["1879-0380"]},"intvolume":" 98","_id":"21759","quality_controlled":"1","project":[{"name":"Understanding the evolution of continuous genomes","_id":"bd6958e0-d553-11ed-ba76-86eba6a76c00","grant_number":"101055327"}],"date_published":"2026-04-15T00:00:00Z","status":"public","month":"04","date_created":"2026-04-26T22:01:46Z","department":[{"_id":"GaTk"},{"_id":"NiBa"}],"citation":{"ama":"Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current Opinion in Genetics and Development. 2026;98. doi:10.1016/j.gde.2026.102472","apa":"Mascolo, E., Körei, R. E., Borst, N. O., Barton, N. H., Crocker, J., & Tkačik, G. (2026). Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current Opinion in Genetics and Development. Elsevier. https://doi.org/10.1016/j.gde.2026.102472","ieee":"E. Mascolo, R. E. Körei, N. O. Borst, N. H. Barton, J. Crocker, and G. Tkačik, “Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges,” Current Opinion in Genetics and Development, vol. 98. Elsevier, 2026.","chicago":"Mascolo, Elia, Reka E Körei, Noa O. Borst, Nicholas H Barton, Justin Crocker, and Gašper Tkačik. “Long-Term Evolution of Regulatory DNA Sequences. Part 2: Theory and Future Challenges.” Current Opinion in Genetics and Development. Elsevier, 2026. https://doi.org/10.1016/j.gde.2026.102472.","ista":"Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. 2026. Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current Opinion in Genetics and Development. 98, 102472.","short":"E. Mascolo, R.E. Körei, N.O. Borst, N.H. Barton, J. Crocker, G. Tkačik, Current Opinion in Genetics and Development 98 (2026).","mla":"Mascolo, Elia, et al. “Long-Term Evolution of Regulatory DNA Sequences. Part 2: Theory and Future Challenges.” Current Opinion in Genetics and Development, vol. 98, 102472, Elsevier, 2026, doi:10.1016/j.gde.2026.102472."},"publisher":"Elsevier","acknowledgement":"We thank Calin Guet and Santiago Herrera-Álvarez for essential contributions to this manuscript.\r\nE.M. acknowledges support from the APART-USA fellowship, jointly funded by the Austrian Academy of Sciences (ÖAW) and the Institute of Science and Technology Austria (ISTA). N.B. acknowledges funding from the ERC Advanced Grant 101055327 “HaplotypeStructure”.\r\nThis study was also supported by the European Molecular Biology Laboratory (N.O.B., J.C.).","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","author":[{"orcid":"0000-0003-2977-7844","full_name":"Mascolo, Elia","id":"776a6ed0-a053-11f0-8635-80b95e0e0d53","first_name":"Elia","last_name":"Mascolo"},{"full_name":"Körei, Reka E","id":"50FDE43E-AA30-11E9-A72B-8A12E6697425","first_name":"Reka E","last_name":"Körei"},{"last_name":"Borst","first_name":"Noa O.","full_name":"Borst, Noa O."},{"first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Crocker, Justin","first_name":"Justin","last_name":"Crocker"},{"id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6699-1455","full_name":"Tkačik, Gašper","first_name":"Gašper","last_name":"Tkačik"}]},{"scopus_import":"1","ddc":["510"],"license":"https://creativecommons.org/licenses/by-nc/4.0/","publication":"Annales Fennici Mathematici","type":"journal_article","date_updated":"2026-04-28T12:06:00Z","article_type":"original","article_processing_charge":"Yes (in subscription journal)","abstract":[{"lang":"eng","text":"We provide a new characterisation of the decades old open problem of extending bilipschitz mappings given on a Euclidean separated net. In particular, this allows for the complete positive solution of the open problem in dimension two. Along the way, we develop a set of tools for bilipschitz extensions of mappings between subsets of Euclidean spaces."}],"corr_author":"1","language":[{"iso":"eng"}],"year":"2026","volume":51,"title":"Extending bilipschitz mappings between separated nets","oa":1,"OA_type":"hybrid","day":"17","publication_status":"published","doi":"10.54330/afm.181562","file_date_updated":"2026-04-28T12:03:13Z","_id":"21766","issue":"1","publication_identifier":{"issn":["2737-0690"],"eissn":["2737-114X"]},"intvolume":" 51","date_published":"2026-04-17T00:00:00Z","project":[{"name":"Spectra and topology of graphs and of simplicial complexes","_id":"fc35eaa2-9c52-11eb-aca3-88501ab155e9","grant_number":"M03100"}],"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"page":"237-260","month":"04","status":"public","publisher":"Finnish Mathematical Society","citation":{"ama":"Dymond M, Kaluza V. Extending bilipschitz mappings between separated nets. Annales Fennici Mathematici. 2026;51(1):237-260. doi:10.54330/afm.181562","apa":"Dymond, M., & Kaluza, V. (2026). Extending bilipschitz mappings between separated nets. Annales Fennici Mathematici. Finnish Mathematical Society. https://doi.org/10.54330/afm.181562","ieee":"M. Dymond and V. Kaluza, “Extending bilipschitz mappings between separated nets,” Annales Fennici Mathematici, vol. 51, no. 1. Finnish Mathematical Society, pp. 237–260, 2026.","mla":"Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between Separated Nets.” Annales Fennici Mathematici, vol. 51, no. 1, Finnish Mathematical Society, 2026, pp. 237–60, doi:10.54330/afm.181562.","short":"M. Dymond, V. Kaluza, Annales Fennici Mathematici 51 (2026) 237–260.","ista":"Dymond M, Kaluza V. 2026. Extending bilipschitz mappings between separated nets. Annales Fennici Mathematici. 51(1), 237–260.","chicago":"Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between Separated Nets.” Annales Fennici Mathematici. Finnish Mathematical Society, 2026. https://doi.org/10.54330/afm.181562."},"department":[{"_id":"UlWa"}],"date_created":"2026-04-26T22:01:47Z","file":[{"file_size":342082,"checksum":"442023926a3803d5d6ca8db8dbc4af1c","success":1,"file_name":"2026_AnnalesFenniciMath_Dymond.pdf","relation":"main_file","access_level":"open_access","date_created":"2026-04-28T12:03:13Z","content_type":"application/pdf","creator":"dernst","file_id":"21772","date_updated":"2026-04-28T12:03:13Z"}],"acknowledgement":"The present work developed from a research visit of M.D. to V.K. at IST Austria, funded by\r\na London Mathematical Society Research in Pairs grant. This work was done while V.K. was fully funded by the Austria Science Fund (FWF) [M 3100-N].","has_accepted_license":"1","keyword":["Lipschitz","bilipschitz","extension","separated net."],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","external_id":{"arxiv":["2507.22007"]},"arxiv":1,"author":[{"full_name":"Dymond, Michael","first_name":"Michael","last_name":"Dymond"},{"orcid":"0000-0002-2512-8698","full_name":"Kaluza, Vojtech","id":"21AE5134-9EAC-11EA-BEA2-D7BD3DDC885E","first_name":"Vojtech","last_name":"Kaluza"}],"OA_place":"publisher"},{"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","month":"01","citation":{"ama":"Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. A polyhedral structure controls programmable self-assembly. Nature Physics. 2026. doi:10.1038/s41567-025-03120-3","apa":"Hübl, M., Videbæk, T. E., Hayakawa, D., Rogers, W. B., & Goodrich, C. P. (2026). A polyhedral structure controls programmable self-assembly. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-025-03120-3","ieee":"M. Hübl, T. E. Videbæk, D. Hayakawa, W. B. Rogers, and C. P. Goodrich, “A polyhedral structure controls programmable self-assembly,” Nature Physics. Springer Nature, 2026.","ista":"Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. 2026. A polyhedral structure controls programmable self-assembly. Nature Physics.","mla":"Hübl, Maximilian, et al. “A Polyhedral Structure Controls Programmable Self-Assembly.” Nature Physics, Springer Nature, 2026, doi:10.1038/s41567-025-03120-3.","short":"M. Hübl, T.E. Videbæk, D. Hayakawa, W.B. Rogers, C.P. Goodrich, Nature Physics (2026).","chicago":"Hübl, Maximilian, Thomas E. Videbæk, Daichi Hayakawa, W. Benjamin Rogers, and Carl Peter Goodrich. “A Polyhedral Structure Controls Programmable Self-Assembly.” Nature Physics. Springer Nature, 2026. https://doi.org/10.1038/s41567-025-03120-3."},"publisher":"Springer Nature","department":[{"_id":"CaGo"},{"_id":"GradSch"}],"date_created":"2026-01-20T10:02:19Z","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"_id":"21006","date_published":"2026-01-08T00:00:00Z","quality_controlled":"1","project":[{"name":"Dynamically reconfigurable self-assembly with triangular DNA-origami bricks","_id":"8dd93da8-16d5-11f0-9cad-d2c70200d9a5","grant_number":"FTI23-G-011"}],"oa_version":"Published Version","related_material":{"link":[{"relation":"press_release","description":"News on ISTA website","url":"https://ista.ac.at/en/news/behind-natures-blueprints/"}]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","author":[{"first_name":"Maximilian","last_name":"Hübl","full_name":"Hübl, Maximilian","id":"5eb8629e-15b2-11ec-abd3-e6f3e5e01f32"},{"full_name":"Videbæk, Thomas E.","last_name":"Videbæk","first_name":"Thomas E."},{"last_name":"Hayakawa","first_name":"Daichi","full_name":"Hayakawa, Daichi"},{"full_name":"Rogers, W. Benjamin","last_name":"Rogers","first_name":"W. Benjamin"},{"last_name":"Goodrich","first_name":"Carl Peter","orcid":"0000-0002-1307-5074","full_name":"Goodrich, Carl Peter","id":"EB352CD2-F68A-11E9-89C5-A432E6697425"}],"OA_place":"publisher","acknowledgement":"We thank B. Isaac and A. Tiano for their technical support with the electron microscopy and S. Waitukaitis for helpful comments on the manuscript. The TEM images were prepared and imaged at the Brandeis Electron Microscopy facility. This work was supported by the Gesellschaft für Forschungsförderung Niederösterreich under project FTI23-G-011 (M.C.H. and C.P.G.), the Brandeis University Materials Research Science and Engineering Center (MRSEC) under grant number NSF DMR-2011846 (T.E.V., D.H. and W.B.R.) and the Smith Family Foundation (W.B.R.). Open access funding provided by Institute of Science and Technology (IST Austria).","has_accepted_license":"1","article_type":"original","article_processing_charge":"Yes (via OA deal)","ddc":["570","540"],"scopus_import":"1","date_updated":"2026-04-28T11:56:45Z","PlanS_conform":"1","publication":"Nature Physics","type":"journal_article","publication_status":"epub_ahead","doi":"10.1038/s41567-025-03120-3","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41567-025-03120-3"}],"abstract":[{"text":"Modern experimental methods in programmable self-assembly make it possible to precisely design particle concentrations, shapes and interactions. However, more physical insight is needed before we can take full advantage of this vast design space to assemble nanostructures with complex form and function. Here we show how a substantial part of this design space can be quickly and comprehensively understood by identifying a class of thermodynamic constraints that act on it. These thermodynamic constraints form a high-dimensional convex polyhedron that determines which nanostructures can be assembled at high equilibrium yield and reveals limitations that govern the coexistence of structures. We validate our predictions through detailed, quantitative assembly experiments of nanoscale particles synthesized using DNA origami. Our results uncover physical relationships underpinning many-component programmable self-assembly in equilibrium and form the basis for robust inverse design, applicable to various systems from biological protein complexes to synthetic nanomachines.","lang":"eng"}],"corr_author":"1","language":[{"iso":"eng"}],"title":"A polyhedral structure controls programmable self-assembly","year":"2026","OA_type":"hybrid","day":"08","oa":1},{"article_type":"original","article_processing_charge":"Yes","ddc":["520"],"scopus_import":"1","date_updated":"2026-04-28T13:08:39Z","PlanS_conform":"1","type":"journal_article","publication":"The Astrophysical Journal","publication_status":"published","doi":"10.3847/1538-4357/ae56ff","ec_funded":1,"file_date_updated":"2026-04-28T13:06:00Z","abstract":[{"text":"3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua and 2I/Borisov. Its unusually high excess velocity and active cometary nature make it a key probe of the Galactic population of icy planetesimals. Understanding its origin requires its past trajectory through the Galaxy to be traced and the possible role of stellar encounters to be assessed, both as a potential origin and a perturber to its orbit. We integrated the orbit of 3I/ATLAS backward in time for 10 Myr, together with a sample of Gaia DR3 stars with high-quality astrometry and radial velocities, to identify close passages within 2 pc. We identify 93 nominal encounters, 62 of which are significant at the 2σ level. However, none of these encounters produced any meaningful perturbation. The strongest perturber Gaia DR3 6863591389529611264 at 0.30 pc and with a relative velocity of 35 km s−1, imparted only a velocity change of ∣Δv∣ ≃ 5 × 10−4 km s−1 to the orbit of 3I/ATLAS. Our results indicate that no stellar flybys within the past 10 Myr and 500 pc contained in Gaia DR3 can account for the present trajectory of 3I/ATLAS or be associated with its origin. We further show that 3I/ATLAS is kinematically consistent with a thin-disk population, despite its large peculiar velocity.","lang":"eng"}],"language":[{"iso":"eng"}],"article_number":"146","title":"3I/ATLAS: In search of the witnesses to its voyage","volume":1001,"year":"2026","OA_type":"gold","day":"20","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","month":"04","citation":{"apa":"Pérez-Couto, X., Torres Rodriguez, S., Villaver, E., Mustill, A. J., & Manteiga, M. (2026). 3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae56ff","ama":"Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal. 2026;1001(2). doi:10.3847/1538-4357/ae56ff","ieee":"X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A. J. Mustill, and M. Manteiga, “3I/ATLAS: In search of the witnesses to its voyage,” The Astrophysical Journal, vol. 1001, no. 2. IOP Publishing, 2026.","chicago":"Pérez-Couto, X., Santiago Torres Rodriguez, E. Villaver, A. J. Mustill, and M. Manteiga. “3I/ATLAS: In Search of the Witnesses to Its Voyage.” The Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae56ff.","short":"X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A.J. Mustill, M. Manteiga, The Astrophysical Journal 1001 (2026).","mla":"Pérez-Couto, X., et al. “3I/ATLAS: In Search of the Witnesses to Its Voyage.” The Astrophysical Journal, vol. 1001, no. 2, 146, IOP Publishing, 2026, doi:10.3847/1538-4357/ae56ff.","ista":"Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 2026. 3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal. 1001(2), 146."},"publisher":"IOP Publishing","department":[{"_id":"LiBu"}],"date_created":"2026-04-26T22:01:46Z","issue":"2","publication_identifier":{"eissn":["1538-4357"],"issn":["0004-637X"]},"intvolume":" 1001","_id":"21760","date_published":"2026-04-20T00:00:00Z","quality_controlled":"1","project":[{"call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413"}],"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Pérez-Couto, X.","last_name":"Pérez-Couto","first_name":"X."},{"first_name":"Santiago","last_name":"Torres Rodriguez","orcid":"0000-0002-3150-8988","full_name":"Torres Rodriguez, Santiago","id":"a8df4360-4328-11ee-8f1a-e502d0c83fc2"},{"last_name":"Villaver","first_name":"E.","full_name":"Villaver, E."},{"first_name":"A. J.","last_name":"Mustill","full_name":"Mustill, A. J."},{"full_name":"Manteiga, M.","first_name":"M.","last_name":"Manteiga"}],"arxiv":1,"external_id":{"arxiv":["2509.07678"]},"DOAJ_listed":"1","OA_place":"publisher","has_accepted_license":"1","acknowledgement":"We thank the anonymous referee for a careful reading of the manuscript and for constructive comments that improved the paper. X.P.C. and S.T. thank J.L. Gragera-Más and Ylva Götberg for their valuable feedback and comments. X.P.C. acknowledges financial support from the Spanish National Programme for the Promotion of Talent and its Employability grant PRE2022-104959 cofunded by the European Social Fund. S.T. acknowledges the funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 101034413. E.V. acknowledges support from the DISCOBOLO project funded by the Spanish Ministerio de Ciencia, Innovación y Universidades under grant PID2021-127289NB-I00. A.J.M. acknowledges support from the Swedish National Space Agency (Career grant 2023-00146). X.P.C. and M.M. acknowledge support from the Spanish Ministerio de Ciencia, Innovaciòn y Universidades under grants PID2021122842OB-C22 and PID2024-157964OB-C22; from the Xunta de Galicia and the European Union (FEDER Galicia 2021-2027 Program) Ref. ED431B 2024/21, ED431B 2024/02, and CITIC ED431G 2023/01. This work has made use of data from the European Space Agency (ESA) Gaia mission and processed by the Gaia Data Processing and Analysis Consortium (DPAC). Funding for the DPAC has been provided by national institutions, particularly the institutions participating in the Gaia Multilateral Agreement.","file":[{"content_type":"application/pdf","creator":"dernst","file_id":"21773","date_updated":"2026-04-28T13:06:00Z","file_size":2905627,"checksum":"c3daf49261a9933c079854c38eec316f","success":1,"file_name":"2026_AstrophysicalJournal_PerezCouto.pdf","relation":"main_file","access_level":"open_access","date_created":"2026-04-28T13:06:00Z"}]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","OA_place":"publisher","external_id":{"pmid":["41881011"]},"author":[{"full_name":"Perez Verdugo, Fernanda L","id":"4ecec223-9070-11ef-a0a9-bc76077bea8d","first_name":"Fernanda L","last_name":"Perez Verdugo"},{"last_name":"Maniou","first_name":"Eirini","full_name":"Maniou, Eirini"},{"full_name":"Galea, Gabriel L.","first_name":"Gabriel L.","last_name":"Galea"},{"last_name":"Banerjee","first_name":"Shiladitya","full_name":"Banerjee, Shiladitya"}],"pmid":1,"file":[{"success":1,"checksum":"80ae45457b4682c50c84f54de15aa9a8","file_size":13402043,"file_name":"2026_CurrentBiology_PerezVerdugo.pdf","date_created":"2026-04-28T13:13:40Z","relation":"main_file","access_level":"open_access","creator":"dernst","content_type":"application/pdf","date_updated":"2026-04-28T13:13:40Z","file_id":"21774"}],"acknowledgement":"S.B. acknowledges support from the National Institutes of Health (NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G. acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society (RG\\R2\\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028. F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros).","has_accepted_license":"1","month":"04","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)"},"page":"1903-1917.e5","date_created":"2026-04-26T22:01:46Z","department":[{"_id":"AnSa"}],"publisher":"Elsevier","citation":{"chicago":"Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology. Elsevier, 2026. https://doi.org/10.1016/j.cub.2026.02.068.","short":"F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36 (2026) 1903–1917.e5.","mla":"Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology, vol. 36, no. 8, Elsevier, 2026, p. 1903–1917.e5, doi:10.1016/j.cub.2026.02.068.","ista":"Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 36(8), 1903–1917.e5.","ama":"Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 2026;36(8):1903-1917.e5. doi:10.1016/j.cub.2026.02.068","ieee":"F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,” Current Biology, vol. 36, no. 8. Elsevier, p. 1903–1917.e5, 2026.","apa":"Perez Verdugo, F. L., Maniou, E., Galea, G. L., & Banerjee, S. (2026). Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2026.02.068"},"_id":"21761","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"issue":"8","intvolume":" 36","quality_controlled":"1","date_published":"2026-04-20T00:00:00Z","doi":"10.1016/j.cub.2026.02.068","publication_status":"published","file_date_updated":"2026-04-28T13:13:40Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Neural tube closure is a critical morphogenetic process in vertebrate development, and failure to close cranial regions such as the hindbrain neuropore (HNP) leads to severe congenital malformations. While mechanical forces such as actomyosin purse-string contraction and directional cell crawling have been implicated in driving HNP closure, how these forces organize local cell shape and motion to produce large-scale tissue remodeling remains poorly understood. Using live and fixed imaging of mouse embryos combined with cell-based biophysical modeling, we show that these force-generating mechanisms are insufficient to explain the reproducible patterns of cell elongation and nematic alignment observed at the HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization are required to generate these patterns and promote midline cell motion. Our model captures key features of cell shape dynamics and emergent nematic order, which we confirm experimentally, including the alignment of actin fibers with cell shape and enhanced midline cell speed. Comparative analysis with chick embryos, which lack supracellular purse strings, supports a conserved link between tension generation and cellular patterning. These findings establish a physical framework connecting force generation, cell shape anisotropy, and tissue morphodynamics during epithelial gap closure."}],"oa":1,"day":"20","OA_type":"hybrid","year":"2026","title":"Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis","volume":36,"article_processing_charge":"Yes (in subscription journal)","article_type":"original","scopus_import":"1","ddc":["570"],"publication":"Current Biology","type":"journal_article","date_updated":"2026-04-28T13:15:42Z"},{"external_id":{"pmid":["41990175"]},"pmid":1,"author":[{"first_name":"Benjamin L","last_name":"Springstein","id":"b4eb62ef-ac72-11ed-9503-ed3b4d66c083","orcid":"0000-0002-3461-5391","full_name":"Springstein, Benjamin L"},{"full_name":"Javoor, Manjunath","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","orcid":"0000-0003-2311-2112","last_name":"Javoor","first_name":"Manjunath"},{"last_name":"Megrian","first_name":"Daniela","full_name":"Megrian, Daniela"},{"first_name":"Roman","last_name":"Hajdu","full_name":"Hajdu, Roman","id":"ffab949d-133f-11ed-8f02-94de21ace503"},{"full_name":"Hanke, Dustin M.","first_name":"Dustin M.","last_name":"Hanke"},{"full_name":"Zens, Bettina","id":"45FD126C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9561-1239","last_name":"Zens","first_name":"Bettina"},{"first_name":"Gregor L.","last_name":"Weiss","full_name":"Weiss, Gregor L."},{"full_name":"Schur, Florian Km","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4790-8078","first_name":"Florian Km","last_name":"Schur"},{"last_name":"Loose","first_name":"Martin","orcid":"0000-0001-7309-9724","id":"462D4284-F248-11E8-B48F-1D18A9856A87","full_name":"Loose, Martin"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"None","acknowledgement":"We thank all members of the Loose lab at ISTA for helpful discussions; M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University) for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work was funded by the European Union’s Horizon 2020 research and innovation program (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques et Letitia Lopez-Loreta Foundation (G.L.W.).","citation":{"ieee":"B. L. Springstein et al., “Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape,” Science, vol. 392, no. 6795. AAAS, 2026.","ama":"Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 2026;392(6795). doi:10.1126/science.aea6343","apa":"Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens, B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. AAAS. https://doi.org/10.1126/science.aea6343","short":"B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L. Weiss, F.K. Schur, M. Loose, Science 392 (2026).","mla":"Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” Science, vol. 392, no. 6795, eaea6343, AAAS, 2026, doi:10.1126/science.aea6343.","ista":"Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL, Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 392(6795), eaea6343.","chicago":"Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu, Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” Science. AAAS, 2026. https://doi.org/10.1126/science.aea6343."},"publisher":"AAAS","department":[{"_id":"MaLo"},{"_id":"FlSc"},{"_id":"GradSch"},{"_id":"EM-Fac"}],"date_created":"2026-04-26T22:01:46Z","month":"04","status":"public","date_published":"2026-04-16T00:00:00Z","project":[{"grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020"},{"grant_number":"101076260","name":"A molecular atlas of Actin filament IDentities in the cell motility machinery","_id":"bd980d18-d553-11ed-ba76-ceaa645c97eb"}],"quality_controlled":"1","_id":"21762","issue":"6795","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"intvolume":" 392","ec_funded":1,"publication_status":"published","doi":"10.1126/science.aea6343","year":"2026","volume":392,"title":"Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape","day":"16","OA_type":"closed access","abstract":[{"lang":"eng","text":"Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal system named CorMR with a function in cell shape control rather than DNA segregation. Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed that CorM formed dynamically unstable, antiparallel double-stranded filaments that were recruited to the membrane by CorR through an amphipathic helix conserved in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which excluded them from the poles and division plane. Comparative genomics indicated that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity, highlighting the evolutionary plasticity of cytoskeletal systems in bacteria."}],"corr_author":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"language":[{"iso":"eng"}],"article_number":"eaea6343","article_type":"original","article_processing_charge":"No","publication":"Science","type":"journal_article","date_updated":"2026-04-28T13:29:05Z","scopus_import":"1"},{"_id":"21755","publication_identifier":{"issn":["0094-8276"],"eissn":["1944-8007"]},"issue":"8","intvolume":" 53","project":[{"grant_number":"101034413","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"}],"quality_controlled":"1","date_published":"2026-04-28T00:00:00Z","month":"04","status":"public","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_created":"2026-04-21T06:04:41Z","department":[{"_id":"CaMu"}],"citation":{"chicago":"Biagioli, Giovanni, Giulio Mandorli, Lilli Johanna Freischem, Alejandro Casallas Garcia, and Adrian Mark Tompkins. “Spatial Patterns of Shallow Clouds: Challenging the Concept of Defined Regimes.” Geophysical Research Letters. Wiley, 2026. https://doi.org/10.1029/2025gl119921.","ista":"Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. 2026. Spatial patterns of shallow clouds: Challenging the concept of defined regimes. Geophysical Research Letters. 53(8), e2025GL119921.","short":"G. Biagioli, G. Mandorli, L.J. Freischem, A. Casallas Garcia, A.M. Tompkins, Geophysical Research Letters 53 (2026).","mla":"Biagioli, Giovanni, et al. “Spatial Patterns of Shallow Clouds: Challenging the Concept of Defined Regimes.” Geophysical Research Letters, vol. 53, no. 8, e2025GL119921, Wiley, 2026, doi:10.1029/2025gl119921.","apa":"Biagioli, G., Mandorli, G., Freischem, L. J., Casallas Garcia, A., & Tompkins, A. M. (2026). Spatial patterns of shallow clouds: Challenging the concept of defined regimes. Geophysical Research Letters. Wiley. https://doi.org/10.1029/2025gl119921","ama":"Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. Spatial patterns of shallow clouds: Challenging the concept of defined regimes. Geophysical Research Letters. 2026;53(8). doi:10.1029/2025gl119921","ieee":"G. Biagioli, G. Mandorli, L. J. Freischem, A. Casallas Garcia, and A. M. Tompkins, “Spatial patterns of shallow clouds: Challenging the concept of defined regimes,” Geophysical Research Letters, vol. 53, no. 8. Wiley, 2026."},"publisher":"Wiley","file":[{"file_id":"21756","date_updated":"2026-04-21T06:07:22Z","content_type":"application/pdf","creator":"acasalla","relation":"main_file","access_level":"open_access","date_created":"2026-04-21T06:07:22Z","success":1,"checksum":"2cd4ae120b14b244f5b2f50eaae0efc1","file_size":1544417,"file_name":"Gio_Casallas_2026.pdf"}],"has_accepted_license":"1","acknowledgement":"GB was supported by an ICTP Postdoctoral Research Fellowship Agreement. GM was supported by the CNRS. AC was supported by the European Union's Horizon 2020 research and innovation programme Marie Sklodowska-Curie Grant agreement No 101034413. LJF acknowledges funding from the NERC Doctoral Training Partnership in Environmental Research Grant NE/S007474/1. We thank three anonymous reviewers and Jiawei Bao for their insightful comments, which greatly improved this manuscript.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","OA_place":"publisher","DOAJ_listed":"1","author":[{"full_name":"Biagioli, Giovanni","last_name":"Biagioli","first_name":"Giovanni"},{"full_name":"Mandorli, Giulio","last_name":"Mandorli","first_name":"Giulio"},{"full_name":"Freischem, Lilli Johanna","last_name":"Freischem","first_name":"Lilli Johanna"},{"first_name":"Alejandro","last_name":"Casallas Garcia","full_name":"Casallas Garcia, Alejandro","id":"92081129-2d75-11ef-a48d-b04dd7a2385a","orcid":"0000-0002-1988-5035"},{"full_name":"Tompkins, Adrian Mark","last_name":"Tompkins","first_name":"Adrian Mark"}],"scopus_import":"1","ddc":["550"],"publication":"Geophysical Research Letters","type":"journal_article","PlanS_conform":"1","date_updated":"2026-04-28T13:35:53Z","article_processing_charge":"Yes","article_type":"original","language":[{"iso":"eng"}],"article_number":"e2025GL119921","abstract":[{"text":"Tropical shallow clouds are a major source of uncertainty in Earth's climate sensitivity, especially through their spatial arrangement, which global climate models do not represent. Efforts to understand their organization have partly relied on classifying observed scenes, identifying four patterns as archetypal regimes. Here we analyze geostationary satellite imagery of the western tropical Atlantic using the L‐function, a tool based on point pattern theory that quantifies cloud organization across spatial scales. Classical examples of the four patterns show distinct L‐function fingerprints, revealing their characteristic clustering and regularity scales and aiding physical interpretation. Yet, when evaluating many scenes at fixed spatial scales, the L‐function distribution lacks the distinct modes expected from discrete regimes. This is corroborated by analyses of other organization indices employing diverse approaches, from inter‐cloud nearest‐neighbor distances to fractal analysis. Implications for the parameterization of mesoscale cloud organization in climate models are discussed.","lang":"eng"}],"oa":1,"day":"28","OA_type":"gold","year":"2026","title":"Spatial patterns of shallow clouds: Challenging the concept of defined regimes","volume":53,"doi":"10.1029/2025gl119921","publication_status":"published","file_date_updated":"2026-04-21T06:07:22Z","ec_funded":1},{"scopus_import":"1","ddc":["570"],"type":"journal_article","publication":"Seminars in Cell and Developmental Biology","PlanS_conform":"1","date_updated":"2026-04-28T14:11:13Z","article_processing_charge":"Yes (in subscription journal)","article_type":"review","language":[{"iso":"eng"}],"article_number":"103670","abstract":[{"text":"Epithelial tissues function as multicellular communities that preserve tissue integrity while adapting to diverse environmental stresses by altering cell behaviors. A striking manifestation of such adaptability is cell plasticity, the ability of differentiated cells to revert to stem-like states or adopt alternative fates. Once considered rare and confined to highly regenerative species, cell plasticity is now recognized across the metazoan tree. In early-branching animals such as sponges and cnidarians, transdifferentiation and dedifferentiation are integral to life-cycle transitions and regeneration, whereas in more complex organisms, these processes typically emerge under stress, including stem cell loss or environmental perturbations. Here, we examine epithelial cell plasticity through evolutionary, cellular, and molecular perspectives. Focusing on the intestinal epithelium, we explore findings from mammalian and Drosophila models showing that progenitors and even terminally differentiated cells can dedifferentiate in response to external stimuli that disrupt homeostasis, such as pathogen infection and nutrient fluctuations. We further discuss conserved mechanisms involving intercellular signaling (e.g., Notch, EGFR, and JAK-STAT) and chromatin states primed for reprogramming, modulated by metabolic cues. Together, these insights position cell plasticity as an ancient environmental adaptation strategy, shaped by conserved molecular toolkits and refined by species- and cell lineage-specific innovations.","lang":"eng"}],"corr_author":"1","oa":1,"OA_type":"hybrid","day":"01","year":"2026","volume":"179-180","title":"Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms","doi":"10.1016/j.semcdb.2026.103670","publication_status":"published","file_date_updated":"2026-04-28T13:58:47Z","_id":"21752","publication_identifier":{"eissn":["1096-3634"],"issn":["1084-9521"]},"quality_controlled":"1","date_published":"2026-05-01T00:00:00Z","month":"05","status":"public","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"department":[{"_id":"XiFe"}],"date_created":"2026-04-19T22:07:49Z","citation":{"short":"H. NAGAI, Y.I. Nakajima, Seminars in Cell and Developmental Biology 179–180 (2026).","mla":"NAGAI, HIROKI, and Yu Ichiro Nakajima. “Epithelial Cell Plasticity in Metazoans: Evolutionary Insights into Roles and Mechanisms.” Seminars in Cell and Developmental Biology, vol. 179–180, 103670, Elsevier, 2026, doi:10.1016/j.semcdb.2026.103670.","ista":"NAGAI H, Nakajima YI. 2026. Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms. Seminars in Cell and Developmental Biology. 179–180, 103670.","chicago":"NAGAI, HIROKI, and Yu Ichiro Nakajima. “Epithelial Cell Plasticity in Metazoans: Evolutionary Insights into Roles and Mechanisms.” Seminars in Cell and Developmental Biology. Elsevier, 2026. https://doi.org/10.1016/j.semcdb.2026.103670.","ama":"NAGAI H, Nakajima YI. Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms. Seminars in Cell and Developmental Biology. 2026;179-180. doi:10.1016/j.semcdb.2026.103670","apa":"NAGAI, H., & Nakajima, Y. I. (2026). Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms. Seminars in Cell and Developmental Biology. Elsevier. https://doi.org/10.1016/j.semcdb.2026.103670","ieee":"H. NAGAI and Y. I. Nakajima, “Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms,” Seminars in Cell and Developmental Biology, vol. 179–180. Elsevier, 2026."},"publisher":"Elsevier","file":[{"creator":"dernst","content_type":"application/pdf","date_updated":"2026-04-28T13:58:47Z","file_id":"21775","file_name":"2026_SeminarsCellDevBiology_Nagai.pdf","file_size":1306613,"checksum":"0a0929a045d0cbd964297768833c14ae","success":1,"date_created":"2026-04-28T13:58:47Z","access_level":"open_access","relation":"main_file"}],"acknowledgement":"This work was supported by JSPS/MEXT KAKENHI (grant numbers JP22J01430 to H.N., JP23H04696, JP23K24025, JP25H02543, JP25K02406 to Y.N.), JST FOREST Program JPMJFR233E (Y.N.), The Cell Science Research Foundation (Y.N.), and Takeda Science Foundation (Y.N.).","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","OA_place":"publisher","author":[{"full_name":"Nagai, Hiroki","id":"608df3e6-e2ab-11ed-8890-c9318cec7da4","orcid":"0000-0003-1671-9434","last_name":"Nagai","first_name":"Hiroki"},{"full_name":"Nakajima, Yu Ichiro","first_name":"Yu Ichiro","last_name":"Nakajima"}]},{"volume":1000,"title":"An eclipsing 8.56 minutes orbital period mass-transferring binary","year":"2026","day":"01","OA_type":"gold","oa":1,"abstract":[{"text":"We report the discovery of ATLAS J101342.5−451656.8 (hereafter ATLAS J1013−4516), an 8.56 minute orbital-period mass-transferring AM Canum Venaticorum (AM CVn) binary with a mean Gaia magnitude of G = 19.51, identified via periodic variability in light curves from the Asteroid Terrestrial-impact Last Alert System (ATLAS) of Gaia white dwarf candidates. Follow-up with the Large Lenslet Array Magellan Spectrograph shows a helium-dominated accretion disk, and high-speed ULTRACAM photometry reveals pronounced primary and secondary eclipses. We construct a decade-long timing baseline leveraging light curves from the ATLAS and Gaia surveys, as well as the high-speed imagers ULTRACAM on the New Energy Telescope and proto-Lightspeed on the Magellan Clay telescope. From this timing baseline, we measure an orbital period derivative of P 1.60 0.07 10 = ± × 12 s s−1. Interpreted in the context of stable mass transfer, the magnitude and sign of P indicate that the orbital evolution is governed by the interplay between gravitationalwave-driven angular-momentum losses and mass transfer, directly probing the donor’s structural response to mass loss. We constrain the accretor and donor mass based on stable mass-transfer arguments assuming angularmomentum loss dominated by gravitational-wave emission, allowing us to infer the characteristic gravitational\r\nwave strain of the binary for future space-based GW observatories such as the Laser Interferometer Space Antenna (LISA). We predict a characteristic strain corresponding to a 4 yr LISA signal-to-noise ratio ≳10, establishing ATLAS J1013−4516 as a strong prospective LISA source that will probe long-term orbital evolution in the mass-transferring regime.","lang":"eng"}],"language":[{"iso":"eng"}],"article_number":"237","file_date_updated":"2026-05-04T06:36:00Z","publication_status":"published","doi":"10.3847/1538-4357/ae4871","date_updated":"2026-05-04T06:37:12Z","type":"journal_article","publication":"The Astrophysical Journal","ddc":["520"],"scopus_import":"1","article_type":"original","article_processing_charge":"Yes","acknowledgement":"This work has made use of data from the Asteroid Terrestrial-impact Last Alert System (ATLAS) project. The Asteroid Terrestrial-impact Last Alert System (ATLAS) project is primarily funded to search for near-Earth asteroids through NASA grants NN12AR55G, 80NSSC18K0284, and 80NSSC18K1575; byproducts of the NEO search include images and catalogs from the survey area. This work was partially funded by Kepler/K2 grant J1944/80NSSC19K0112 and HST GO-15889 and STFC grants ST/T000198/1 and ST/S006109/1. The ATLAS science products have been made possible through the contributions of the University of Hawaii Institute for Astronomy, the Queen’s University Belfast, the Space Telescope Science Institute, the South African Astronomical Observatory, and the Millennium Institute of Astrophysics (MAS), Chile. VSD and ULTRACAM are supported by STFC grant ST/Z000033/1. J.G.M. gratefully acknowledges support from the Heising-Simons Foundation and the Pappalardo family through the MIT Pappalardo Fellowship in Physics.","has_accepted_license":"1","file":[{"date_created":"2026-05-04T06:36:00Z","access_level":"open_access","relation":"main_file","file_name":"2026_AstrophysicalJournal_Chickles.pdf","checksum":"c8f64a78f36224d8e0ea1f324e43e389","success":1,"file_size":1225916,"date_updated":"2026-05-04T06:36:00Z","file_id":"21782","creator":"dernst","content_type":"application/pdf"}],"author":[{"full_name":"Chickles, Emma T.","last_name":"Chickles","first_name":"Emma T."},{"full_name":"Chakraborty, Joheen","last_name":"Chakraborty","first_name":"Joheen"},{"first_name":"Kevin B.","last_name":"Burdge","full_name":"Burdge, Kevin B."},{"last_name":"Dhillon","first_name":"Vik S.","full_name":"Dhillon, Vik S."},{"full_name":"Draghis, Paul","first_name":"Paul","last_name":"Draghis"},{"first_name":"Kareem","last_name":"El-Badry","full_name":"El-Badry, Kareem"},{"full_name":"Green, Matthew J.","last_name":"Green","first_name":"Matthew J."},{"first_name":"Aaron","last_name":"Householder","full_name":"Householder, Aaron"},{"first_name":"Sarah","last_name":"Hughes","full_name":"Hughes, Sarah"},{"first_name":"Christopher","last_name":"Layden","full_name":"Layden, Christopher"},{"full_name":"Littlefair, Stuart P.","first_name":"Stuart P.","last_name":"Littlefair"},{"first_name":"James","last_name":"Munday","full_name":"Munday, James"},{"last_name":"Pelisoli","first_name":"Ingrid","full_name":"Pelisoli, Ingrid"},{"full_name":"Redden, Maya S.","last_name":"Redden","first_name":"Maya S."},{"full_name":"Tonry, John","first_name":"John","last_name":"Tonry"},{"last_name":"van Roestel","first_name":"Joannes C","id":"4d122fc8-6083-11f0-87a5-97d68b860333","full_name":"van Roestel, Joannes C"},{"last_name":"Angile","first_name":"Francesco Elio","full_name":"Angile, Francesco Elio"},{"full_name":"Brown, Alex J.","last_name":"Brown","first_name":"Alex J."},{"last_name":"Segura","first_name":"Noel Castro","full_name":"Segura, Noel Castro"},{"full_name":"Dinsmore, Jack","first_name":"Jack","last_name":"Dinsmore"},{"first_name":"Martin","last_name":"Dyer","full_name":"Dyer, Martin"},{"last_name":"Furesz","first_name":"Gabor","full_name":"Furesz, Gabor"},{"last_name":"Gabutti","first_name":"Michelle","full_name":"Gabutti, Michelle"},{"first_name":"James","last_name":"Garbutt","full_name":"Garbutt, James"},{"full_name":"García-Mejía, Juliana","last_name":"García-Mejía","first_name":"Juliana"},{"full_name":"Jarvis, Daniel","first_name":"Daniel","last_name":"Jarvis"},{"full_name":"Kennedy, Mark R.","last_name":"Kennedy","first_name":"Mark R."},{"full_name":"Kerry, Paul","first_name":"Paul","last_name":"Kerry"},{"first_name":"James","last_name":"Mccormac","full_name":"Mccormac, James"},{"full_name":"Mo, Geoffrey","last_name":"Mo","first_name":"Geoffrey"},{"full_name":"Osip, Dave","last_name":"Osip","first_name":"Dave"},{"first_name":"Steven","last_name":"Parsons","full_name":"Parsons, Steven"},{"full_name":"Pike, Eleanor","last_name":"Pike","first_name":"Eleanor"},{"full_name":"Piotrowski, John J.","last_name":"Piotrowski","first_name":"John J."},{"first_name":"Roger W.","last_name":"Romani","full_name":"Romani, Roger W."},{"full_name":"Sahman, David","first_name":"David","last_name":"Sahman"},{"last_name":"Simcoe","first_name":"Rob","full_name":"Simcoe, Rob"}],"DOAJ_listed":"1","arxiv":1,"external_id":{"arxiv":["2601.07925"]},"OA_place":"publisher","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2026-04-01T00:00:00Z","quality_controlled":"1","issue":"2","intvolume":" 1000","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"_id":"21705","citation":{"chicago":"Chickles, Emma T., Joheen Chakraborty, Kevin B. Burdge, Vik S. Dhillon, Paul Draghis, Kareem El-Badry, Matthew J. Green, et al. “An Eclipsing 8.56 Minutes Orbital Period Mass-Transferring Binary.” The Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae4871.","short":"E.T. Chickles, J. Chakraborty, K.B. Burdge, V.S. Dhillon, P. Draghis, K. El-Badry, M.J. Green, A. Householder, S. Hughes, C. Layden, S.P. Littlefair, J. Munday, I. Pelisoli, M.S. Redden, J. Tonry, J.C. van Roestel, F.E. Angile, A.J. Brown, N.C. Segura, J. Dinsmore, M. Dyer, G. Furesz, M. Gabutti, J. Garbutt, J. García-Mejía, D. Jarvis, M.R. Kennedy, P. Kerry, J. Mccormac, G. Mo, D. Osip, S. Parsons, E. Pike, J.J. Piotrowski, R.W. Romani, D. Sahman, R. Simcoe, The Astrophysical Journal 1000 (2026).","mla":"Chickles, Emma T., et al. “An Eclipsing 8.56 Minutes Orbital Period Mass-Transferring Binary.” The Astrophysical Journal, vol. 1000, no. 2, 237, IOP Publishing, 2026, doi:10.3847/1538-4357/ae4871.","ista":"Chickles ET, Chakraborty J, Burdge KB, Dhillon VS, Draghis P, El-Badry K, Green MJ, Householder A, Hughes S, Layden C, Littlefair SP, Munday J, Pelisoli I, Redden MS, Tonry J, van Roestel JC, Angile FE, Brown AJ, Segura NC, Dinsmore J, Dyer M, Furesz G, Gabutti M, Garbutt J, García-Mejía J, Jarvis D, Kennedy MR, Kerry P, Mccormac J, Mo G, Osip D, Parsons S, Pike E, Piotrowski JJ, Romani RW, Sahman D, Simcoe R. 2026. An eclipsing 8.56 minutes orbital period mass-transferring binary. The Astrophysical Journal. 1000(2), 237.","apa":"Chickles, E. T., Chakraborty, J., Burdge, K. B., Dhillon, V. S., Draghis, P., El-Badry, K., … Simcoe, R. (2026). An eclipsing 8.56 minutes orbital period mass-transferring binary. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae4871","ieee":"E. T. Chickles et al., “An eclipsing 8.56 minutes orbital period mass-transferring binary,” The Astrophysical Journal, vol. 1000, no. 2. IOP Publishing, 2026.","ama":"Chickles ET, Chakraborty J, Burdge KB, et al. An eclipsing 8.56 minutes orbital period mass-transferring binary. The Astrophysical Journal. 2026;1000(2). doi:10.3847/1538-4357/ae4871"},"publisher":"IOP Publishing","date_created":"2026-04-12T22:01:47Z","department":[{"_id":"IlCa"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","month":"04"},{"acknowledgement":"We would like to thank the anonymous reviewer for their constructive comments, which improved the final manuscript.\r\n\r\nWe thank Bernd Husemann for his critical contributions to the NIRSpec Wide GTO survey, and in particular his help in selecting high-priority X-ray-luminous targets.\r\n\r\nR.E.H. acknowledges support by the German Aerospace Center (DLR) and the Federal Ministry for Economic Affairs and Energy (BMWi) through program 50OR2403 “RUBIES.” A.d.G. acknowledges support from a Clay Fellowship awarded by the Smithsonian Astrophysical Observatory. A.J.B. acknowledges funding from the “FirstGalaxies” Advanced grant from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No. 789056). R.P.N. thanks Neil Pappalardo and Jane Pappalardo for their generous support of the MIT Pappalardo Fellowships in Physics. Support for this work was provided by the Brinson Foundation through a Brinson Prize Fellowship grant. H.Ü. acknowledges funding by the European Union (ERC APEX, 101164796). Views and opinions expressed are, however, those of the authors only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. G.V. acknowledges support from European Union’s HE ERC Starting grant No. 101040227—WINGS. B.W. acknowledges support provided by NASA through Hubble Fellowship grant HST-HF2-51592.001 awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, In., for NASA, under the contract NAS 5-26555.\r\n\r\nThe data products presented herein were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN).\r\n\r\nThis work is based in part on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs Nos. GTO-1213. The data described here may be obtained from the MAST archive at DOI: 10.17909/qffz-b324.\r\n\r\nThis Letter employs a list of Chandra datasets, obtained by the Chandra X-ray Observatory, contained in DOI: 10.25574/cdc.540.\r\n\r\nThis work is based on observations taken by the 3D-HST Treasury Program (GO 12177 and 12328) with the NASA/ESA HST, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.\r\n\r\nThis work makes use of color palettes created by Martin Krzywinski designed for colorblindness. The color palettes and more information can be found at http://mkweb.bcgsc.ca/colorblind/.\r\n\r\nFacilities: CXO - Chandra X-ray Observatory satellite (ACIS), HST - Hubble Space Telescope satellite (ACS, WFC3) - , CFHT - Canada-France-Hawaii Telescope (WIRCam), JWST - James Webb Space Telescope (NIRSpec), Spitzer - Spitzer Space Telescope satellite (IRAC, MIPS) - , JCMT - James Clerk Maxwell Telescope (SCUBA).\r\n\r\nSoftware: Astropy (Astropy Collaboration et al. 2013, 2018, 2022), dust_attenuation, dust_extinction (K. Gordon 2024), jax (J. Bradbury et al. 2018), LaTeX (L. Lamport 1994), Matplotlib (J. D. Hunter 2007), NumPy (T. E. Oliphant 2006; S. van der Walt et al. 2011; C. R. Harris et al. 2020), NumPyro (D. Phan et al. 2019), scipy (P. Virtanen et al. 2020), sedpy (B. Johnson & J. Leja 2017), specutils (Astropy-Specutils Development Team 2019), unite (R. E. Hviding 2025).","has_accepted_license":"1","file":[{"success":1,"checksum":"1be4f361bf59aa08b8c98ed4f475a463","file_size":2821786,"file_name":"2026_AstrophysicalJourLetters_Hviding.pdf","relation":"main_file","access_level":"open_access","date_created":"2026-05-04T07:11:37Z","content_type":"application/pdf","creator":"dernst","date_updated":"2026-05-04T07:11:37Z","file_id":"21784"}],"author":[{"full_name":"Hviding, Raphael E.","last_name":"Hviding","first_name":"Raphael E."},{"full_name":"De Graaff, Anna","last_name":"De Graaff","first_name":"Anna"},{"full_name":"Liu, Hanpu","last_name":"Liu","first_name":"Hanpu"},{"full_name":"Goulding, Andy D.","last_name":"Goulding","first_name":"Andy D."},{"last_name":"Ma","first_name":"Yilun","full_name":"Ma, Yilun"},{"last_name":"Greene","first_name":"Jenny E.","full_name":"Greene, Jenny E."},{"full_name":"Boogaard, Leindert A.","last_name":"Boogaard","first_name":"Leindert A."},{"first_name":"Andrew J.","last_name":"Bunker","full_name":"Bunker, Andrew J."},{"full_name":"Cleri, Nikko J.","last_name":"Cleri","first_name":"Nikko J."},{"first_name":"Marijn","last_name":"Franx","full_name":"Franx, Marijn"},{"first_name":"Michaela","last_name":"Hirschmann","full_name":"Hirschmann, Michaela"},{"last_name":"Leja","first_name":"Joel","full_name":"Leja, Joel"},{"last_name":"Matthee","first_name":"Jorryt J","full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"full_name":"Naidu, Rohan P.","first_name":"Rohan P.","last_name":"Naidu"},{"first_name":"David J.","last_name":"Setton","full_name":"Setton, David J."},{"full_name":"Übler, Hannah","first_name":"Hannah","last_name":"Übler"},{"first_name":"Giacomo","last_name":"Venturi","full_name":"Venturi, Giacomo"},{"full_name":"Wang, Bingjie","last_name":"Wang","first_name":"Bingjie"}],"external_id":{"arxiv":["2601.09778"]},"arxiv":1,"DOAJ_listed":"1","OA_place":"publisher","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2026-03-20T00:00:00Z","quality_controlled":"1","issue":"1","publication_identifier":{"eissn":["2041-8213"],"issn":["2041-8205"]},"intvolume":" 1000","_id":"21709","citation":{"chicago":"Hviding, Raphael E., Anna De Graaff, Hanpu Liu, Andy D. Goulding, Yilun Ma, Jenny E. Greene, Leindert A. Boogaard, et al. “The X-Ray Dot: Exotic Dust or a Late-Stage Little Red Dot?” The Astrophysical Journal Letters. IOP Publishing, 2026. https://doi.org/10.3847/2041-8213/ae4c88.","ista":"Hviding RE, De Graaff A, Liu H, Goulding AD, Ma Y, Greene JE, Boogaard LA, Bunker AJ, Cleri NJ, Franx M, Hirschmann M, Leja J, Matthee JJ, Naidu RP, Setton DJ, Übler H, Venturi G, Wang B. 2026. The X-ray dot: Exotic dust or a late-stage Little Red Dot? The Astrophysical Journal Letters. 1000(1), L18.","short":"R.E. Hviding, A. De Graaff, H. Liu, A.D. Goulding, Y. Ma, J.E. Greene, L.A. Boogaard, A.J. Bunker, N.J. Cleri, M. Franx, M. Hirschmann, J. Leja, J.J. Matthee, R.P. Naidu, D.J. Setton, H. Übler, G. Venturi, B. Wang, The Astrophysical Journal Letters 1000 (2026).","mla":"Hviding, Raphael E., et al. “The X-Ray Dot: Exotic Dust or a Late-Stage Little Red Dot?” The Astrophysical Journal Letters, vol. 1000, no. 1, L18, IOP Publishing, 2026, doi:10.3847/2041-8213/ae4c88.","ieee":"R. E. Hviding et al., “The X-ray dot: Exotic dust or a late-stage Little Red Dot?,” The Astrophysical Journal Letters, vol. 1000, no. 1. IOP Publishing, 2026.","ama":"Hviding RE, De Graaff A, Liu H, et al. The X-ray dot: Exotic dust or a late-stage Little Red Dot? The Astrophysical Journal Letters. 2026;1000(1). doi:10.3847/2041-8213/ae4c88","apa":"Hviding, R. E., De Graaff, A., Liu, H., Goulding, A. D., Ma, Y., Greene, J. E., … Wang, B. (2026). The X-ray dot: Exotic dust or a late-stage Little Red Dot? The Astrophysical Journal Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ae4c88"},"publisher":"IOP Publishing","department":[{"_id":"JoMa"}],"date_created":"2026-04-12T22:01:48Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","month":"03","volume":1000,"title":"The X-ray dot: Exotic dust or a late-stage Little Red Dot?","year":"2026","OA_type":"gold","day":"20","oa":1,"abstract":[{"lang":"eng","text":"JWST’s “little red dots” (LRDs) are increasingly interpreted as active galactic nuclei (AGN) obscured by dense thermalized gas rather than dust as evidenced by their X-ray weakness, blackbody-like continua, and Balmer line profiles. Key questions are how LRDs connect to standard UV-luminous AGN, whether transitional phases exist, and whether they are observable. We present the “X-ray dot” (XRD), a compact source at z = 3.28 observed by the NIRSpec Wide Guaranteed Time Observation survey. The XRD exhibits LRD hallmarks: a blackbody-like (Teff ≃ 6400 K) red continuum, a faint but blue rest-UV excess, falling mid-IR emission, and broad Balmer lines (FWHM ∼ 2700–3200 km s−1). Unlike LRDs, however, it is remarkably X-ray luminous (L2−10 keV = 1044.18 erg s−1) and has a continuum inflection that is blueward of the Balmer limit. We find that the red rest-optical and blue mid-IR continuum cannot be reproduced by standard dust-attenuated AGN models without invoking extremely steep extinction curves, nor can the weak mid-IR emission be reconciled with well-established X-ray–torus scaling relations. We therefore consider an alternative scenario: the XRD may be an LRD in transition, where the gas envelope dominates the optical continuum but optically thin sight lines allow X-rays to escape. The XRD may thus provide a physical link between LRDs and standard AGN, offering direct evidence that LRDs are powered by supermassive black holes and providing insight into their accretion properties."}],"article_number":"L18","language":[{"iso":"eng"}],"file_date_updated":"2026-05-04T07:11:37Z","publication_status":"published","doi":"10.3847/2041-8213/ae4c88","date_updated":"2026-05-04T07:13:07Z","type":"journal_article","publication":"The Astrophysical Journal Letters","ddc":["520"],"scopus_import":"1","article_type":"original","article_processing_charge":"Yes"}]