[{"day":"22","article_number":"2409.14299","date_updated":"2026-04-13T10:49:12Z","_id":"21685","date_created":"2026-04-09T09:10:41Z","abstract":[{"lang":"eng","text":"Nonlinear optics has become the workhorse for countless applications in classical and quantum optics, from optical bistability to single photon pair generation. However, the intrinsic weakness of optical nonlinearity has meant that large input powers and weak output powers are often a necessity in nonlinear frequency conversion. Here, motivated by recent advances in using non-Hermitian photonics and gain/loss engineering to enable non-reciprocal light transport, we explore how the interplay between non-Hermiticity and optical nonlinearity leads to a fundamentally new regime of nonlinear frequency conversion. We show how non-Hermitian coupling between discrete frequency modes can result in non-reciprocal flow of energy in the frequency dimension, closely resembling the non-Hermitian skin effect (NHSE). Applying our theory to a multimode nonlinear cavity supporting cascaded nonlinear processes, we create an asymmetric infrared (IR) comb that features a ``skin'' frequency mode populated with efficiency exceeding 85\\%. Furthermore, we demonstrate how three-wave mixing processes in the non-reciprocal infrared comb we generate enables terahertz (THz) generation exceeding the Manley-Rowe limit. We then show how the non-reciprocal frequency conversion is robust against cavity defects and disorder that cause random fluctuations in the dissipation rate for different modes. Moreover, in certain regimes, the nonlinear, non-Hermitian system supports stable limit cycles that can enable multimode pulsing with picosecond pulse widths and GHz repetition rates. Finally, we explore how the system can be applied to generate simultaneous IR and THz frequency combs, potentially unlocking novel applications in spectroscopy and metrology."}],"scopus_import":"1","extern":"1","month":"09","language":[{"iso":"eng"}],"oa_version":"Preprint","OA_place":"repository","publication":"arXiv","external_id":{"arxiv":["2409.14299"]},"status":"public","oa":1,"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2409.14299","open_access":"1"}],"article_processing_charge":"No","arxiv":1,"citation":{"mla":"Pontula, Sahil, et al. “Non-Reciprocal Frequency Conversion in a Multimode Nonlinear System.” <i>ArXiv</i>, 2409.14299, doi:<a href=\"https://doi.org/10.48550/arXiv.2409.14299\">10.48550/arXiv.2409.14299</a>.","ama":"Pontula S, Vaidya S, Roques-Carmes C, Uddin SZ, Soljacic M, Salamin Y. Non-reciprocal frequency conversion in a multimode nonlinear system. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2409.14299\">10.48550/arXiv.2409.14299</a>","ista":"Pontula S, Vaidya S, Roques-Carmes C, Uddin SZ, Soljacic M, Salamin Y. Non-reciprocal frequency conversion in a multimode nonlinear system. arXiv, 2409.14299.","ieee":"S. Pontula, S. Vaidya, C. Roques-Carmes, S. Z. Uddin, M. Soljacic, and Y. Salamin, “Non-reciprocal frequency conversion in a multimode nonlinear system,” <i>arXiv</i>. .","chicago":"Pontula, Sahil, Sachin Vaidya, Charles Roques-Carmes, Shiekh Zia Uddin, Marin Soljacic, and Yannick Salamin. “Non-Reciprocal Frequency Conversion in a Multimode Nonlinear System.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2409.14299\">https://doi.org/10.48550/arXiv.2409.14299</a>.","apa":"Pontula, S., Vaidya, S., Roques-Carmes, C., Uddin, S. Z., Soljacic, M., &#38; Salamin, Y. (n.d.). Non-reciprocal frequency conversion in a multimode nonlinear system. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2409.14299\">https://doi.org/10.48550/arXiv.2409.14299</a>","short":"S. Pontula, S. Vaidya, C. Roques-Carmes, S.Z. Uddin, M. Soljacic, Y. Salamin, ArXiv (n.d.)."},"date_published":"2024-09-22T00:00:00Z","author":[{"last_name":"Pontula","first_name":"Sahil","full_name":"Pontula, Sahil"},{"full_name":"Vaidya, Sachin","last_name":"Vaidya","first_name":"Sachin"},{"first_name":"Charles","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","last_name":"Roques-Carmes","full_name":"Roques-Carmes, Charles"},{"full_name":"Uddin, Shiekh Zia","last_name":"Uddin","first_name":"Shiekh Zia"},{"full_name":"Soljacic, Marin","last_name":"Soljacic","first_name":"Marin"},{"last_name":"Salamin","first_name":"Yannick","full_name":"Salamin, Yannick"}],"publication_status":"submitted","type":"preprint","title":"Non-reciprocal frequency conversion in a multimode nonlinear system","doi":"10.48550/arXiv.2409.14299","fulldoi":"https://doi.org/10.48550/arXiv.2409.14299","OA_type":"green","year":"2024","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2409.17002"}],"oa":1,"article_processing_charge":"No","citation":{"ieee":"O. Y. Long <i>et al.</i>, “Nonreciprocal scintillation using one-dimensional magneto-optical photonic crystals,” <i>arXiv</i>. .","ista":"Long OY, Pajovic S, Roques-Carmes C, Tsurimaki Y, Rivera N, Soljačić M, Boriskina SV, Fan S. Nonreciprocal scintillation using one-dimensional magneto-optical photonic crystals. arXiv, 2409.17002.","ama":"Long OY, Pajovic S, Roques-Carmes C, et al. Nonreciprocal scintillation using one-dimensional magneto-optical photonic crystals. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2409.17002\">10.48550/arXiv.2409.17002</a>","mla":"Long, Olivia Y., et al. “Nonreciprocal Scintillation Using One-Dimensional Magneto-Optical Photonic Crystals.” <i>ArXiv</i>, 2409.17002, doi:<a href=\"https://doi.org/10.48550/arXiv.2409.17002\">10.48550/arXiv.2409.17002</a>.","short":"O.Y. Long, S. Pajovic, C. Roques-Carmes, Y. Tsurimaki, N. Rivera, M. Soljačić, S.V. Boriskina, S. Fan, ArXiv (n.d.).","chicago":"Long, Olivia Y., Simo Pajovic, Charles Roques-Carmes, Yoichiro Tsurimaki, Nicholas Rivera, Marin Soljačić, Svetlana V. Boriskina, and Shanhui Fan. “Nonreciprocal Scintillation Using One-Dimensional Magneto-Optical Photonic Crystals.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2409.17002\">https://doi.org/10.48550/arXiv.2409.17002</a>.","apa":"Long, O. Y., Pajovic, S., Roques-Carmes, C., Tsurimaki, Y., Rivera, N., Soljačić, M., … Fan, S. (n.d.). Nonreciprocal scintillation using one-dimensional magneto-optical photonic crystals. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2409.17002\">https://doi.org/10.48550/arXiv.2409.17002</a>"},"arxiv":1,"OA_place":"repository","external_id":{"arxiv":["2409.17002"]},"publication":"arXiv","status":"public","oa_version":"Preprint","extern":"1","month":"09","language":[{"iso":"eng"}],"scopus_import":"1","abstract":[{"text":"Scintillation describes the conversion of high-energy particles into light in transparent media and finds diverse applications such as high-energy particle detection and industrial and medical imaging. This process operates on multiple timescales, with the final radiative step consisting of spontaneous emission, which can be modeled within the framework of quasi-equilibrium fluctuational electrodynamics. Scintillation can therefore be controlled and enhanced via nanophotonic effects, which has been proposed and experimentally demonstrated. Such designs have thus far obeyed Lorentz reciprocity, meaning there is a direct equivalence between scintillation emission and absorption by the scintillator. However, scintillators that do not obey Lorentz reciprocity have not been explored, even though they represent a novel platform for probing emission which is both nonequilibrium and nonreciprocal in nature. In this work, we propose to harness nonreciprocity to achieve directional control of scintillation emission, granting an additional degree of control over scintillation. Such directionality of light output is important in improving collection efficiencies along the directions where detectors are located. We present the design of a nonreciprocal scintillator using a one-dimensional magnetophotonic crystal in the Voigt configuration. Our work demonstrates the potential of controlling nonequilibrium emission such as scintillation by breaking reciprocity and expands the space of nanophotonic design for achieving such control.","lang":"eng"}],"date_created":"2026-04-09T09:10:41Z","article_number":"2409.17002","day":"25","date_updated":"2026-04-13T10:48:09Z","_id":"21686","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"green","fulldoi":"https://doi.org/10.48550/arXiv.2409.17002","year":"2024","title":"Nonreciprocal scintillation using one-dimensional magneto-optical photonic crystals","doi":"10.48550/arXiv.2409.17002","type":"preprint","author":[{"last_name":"Long","first_name":"Olivia Y.","full_name":"Long, Olivia Y."},{"full_name":"Pajovic, Simo","last_name":"Pajovic","first_name":"Simo"},{"last_name":"Roques-Carmes","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","first_name":"Charles","full_name":"Roques-Carmes, Charles"},{"last_name":"Tsurimaki","first_name":"Yoichiro","full_name":"Tsurimaki, Yoichiro"},{"full_name":"Rivera, Nicholas","first_name":"Nicholas","last_name":"Rivera"},{"full_name":"Soljačić, Marin","last_name":"Soljačić","first_name":"Marin"},{"first_name":"Svetlana V.","last_name":"Boriskina","full_name":"Boriskina, Svetlana V."},{"first_name":"Shanhui","last_name":"Fan","full_name":"Fan, Shanhui"}],"date_published":"2024-09-25T00:00:00Z","publication_status":"submitted"},{"type":"preprint","title":"Computational metaoptics for imaging","doi":"10.48550/arXiv.2411.09133","publication_status":"submitted","author":[{"full_name":"Roques-Carmes, Charles","first_name":"Charles","last_name":"Roques-Carmes","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82"},{"last_name":"Wang","first_name":"Kai","full_name":"Wang, Kai"},{"first_name":"Yuanmu","last_name":"Yang","full_name":"Yang, Yuanmu"},{"first_name":"Arka","last_name":"Majumdar","full_name":"Majumdar, Arka"},{"last_name":"Lin","first_name":"Zin","full_name":"Lin, Zin"}],"date_published":"2024-11-14T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"green","fulldoi":"https://doi.org/10.48550/arXiv.2411.09133","year":"2024","day":"14","article_number":"2411.09133","_id":"21689","date_updated":"2026-04-13T09:53:49Z","scopus_import":"1","abstract":[{"text":"Metasurfaces -- ultrathin structures composed of subwavelength optical elements -- have revolutionized light manipulation by enabling precise control over electromagnetic waves' amplitude, phase, polarization, and spectral properties. Concurrently, computational imaging leverages algorithms to reconstruct images from optically processed signals, overcoming limitations of traditional imaging systems. This review explores the synergistic integration of metaoptics and computational imaging, \"computational metaoptics,\" which combines the physical wavefront shaping ability of metasurfaces with advanced computational algorithms to enhance imaging performance beyond conventional limits. We discuss how computational metaoptics addresses the inherent limitations of single-layer metasurfaces in achieving multifunctionality without compromising efficiency. By treating metasurfaces as physical preconditioners and co-designing them with reconstruction algorithms through end-to-end (inverse) design, it is possible to jointly optimize the optical hardware and computational software. This holistic approach allows for the automatic discovery of optimal metasurface designs and reconstruction methods that significantly improve imaging capabilities. Advanced applications enabled by computational metaoptics are highlighted, including phase imaging and quantum state measurement, which benefit from the metasurfaces' ability to manipulate complex light fields and the computational algorithms' capacity to reconstruct high-dimensional information. We also examine performance evaluation challenges, emphasizing the need for new metrics that account for the combined optical and computational nature of these systems. Finally, we identify new frontiers in computational metaoptics which point toward a future where computational metaoptics may play a central role in advancing imaging science and technology.","lang":"eng"}],"date_created":"2026-04-09T09:10:41Z","OA_place":"repository","external_id":{"arxiv":["2411.09133"]},"publication":"arXiv","status":"public","oa":1,"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2411.09133","open_access":"1"}],"article_processing_charge":"No","citation":{"short":"C. Roques-Carmes, K. Wang, Y. Yang, A. Majumdar, Z. Lin, ArXiv (n.d.).","chicago":"Roques-Carmes, Charles, Kai Wang, Yuanmu Yang, Arka Majumdar, and Zin Lin. “Computational Metaoptics for Imaging.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2411.09133\">https://doi.org/10.48550/arXiv.2411.09133</a>.","apa":"Roques-Carmes, C., Wang, K., Yang, Y., Majumdar, A., &#38; Lin, Z. (n.d.). Computational metaoptics for imaging. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2411.09133\">https://doi.org/10.48550/arXiv.2411.09133</a>","ieee":"C. Roques-Carmes, K. Wang, Y. Yang, A. Majumdar, and Z. Lin, “Computational metaoptics for imaging,” <i>arXiv</i>. .","ama":"Roques-Carmes C, Wang K, Yang Y, Majumdar A, Lin Z. Computational metaoptics for imaging. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2411.09133\">10.48550/arXiv.2411.09133</a>","ista":"Roques-Carmes C, Wang K, Yang Y, Majumdar A, Lin Z. Computational metaoptics for imaging. arXiv, 2411.09133.","mla":"Roques-Carmes, Charles, et al. “Computational Metaoptics for Imaging.” <i>ArXiv</i>, 2411.09133, doi:<a href=\"https://doi.org/10.48550/arXiv.2411.09133\">10.48550/arXiv.2411.09133</a>."},"arxiv":1,"extern":"1","month":"11","language":[{"iso":"eng"}],"oa_version":"Preprint"},{"year":"2024","fulldoi":"https://doi.org/10.48550/arXiv.2412.02887","OA_type":"green","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2024-12-03T00:00:00Z","publication_status":"submitted","author":[{"full_name":"Gu, Alex","last_name":"Gu","first_name":"Alex"},{"full_name":"Sloan, Jamison","last_name":"Sloan","first_name":"Jamison"},{"id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","last_name":"Roques-Carmes","first_name":"Charles","full_name":"Roques-Carmes, Charles"},{"last_name":"Choi","first_name":"Seou","full_name":"Choi, Seou"},{"full_name":"Rosenthal, Eric I.","first_name":"Eric I.","last_name":"Rosenthal"},{"full_name":"Horodynski, Michael","first_name":"Michael","last_name":"Horodynski"},{"first_name":"Yannick","last_name":"Salamin","full_name":"Salamin, Yannick"},{"full_name":"Vučković, Jelena","last_name":"Vučković","first_name":"Jelena"},{"first_name":"Marin","last_name":"Soljačić","full_name":"Soljačić, Marin"}],"type":"preprint","doi":"10.48550/arXiv.2412.02887","title":"Quantum sensitivity of parametric oscillators","language":[{"iso":"eng"}],"month":"12","extern":"1","oa_version":"Preprint","status":"public","publication":"arXiv","OA_place":"repository","external_id":{"arxiv":["2412.02887"]},"citation":{"apa":"Gu, A., Sloan, J., Roques-Carmes, C., Choi, S., Rosenthal, E. I., Horodynski, M., … Soljačić, M. (n.d.). Quantum sensitivity of parametric oscillators. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2412.02887\">https://doi.org/10.48550/arXiv.2412.02887</a>","chicago":"Gu, Alex, Jamison Sloan, Charles Roques-Carmes, Seou Choi, Eric I. Rosenthal, Michael Horodynski, Yannick Salamin, Jelena Vučković, and Marin Soljačić. “Quantum Sensitivity of Parametric Oscillators.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2412.02887\">https://doi.org/10.48550/arXiv.2412.02887</a>.","short":"A. Gu, J. Sloan, C. Roques-Carmes, S. Choi, E.I. Rosenthal, M. Horodynski, Y. Salamin, J. Vučković, M. Soljačić, ArXiv (n.d.).","mla":"Gu, Alex, et al. “Quantum Sensitivity of Parametric Oscillators.” <i>ArXiv</i>, :2412.02887, doi:<a href=\"https://doi.org/10.48550/arXiv.2412.02887\">10.48550/arXiv.2412.02887</a>.","ama":"Gu A, Sloan J, Roques-Carmes C, et al. Quantum sensitivity of parametric oscillators. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2412.02887\">10.48550/arXiv.2412.02887</a>","ista":"Gu A, Sloan J, Roques-Carmes C, Choi S, Rosenthal EI, Horodynski M, Salamin Y, Vučković J, Soljačić M. Quantum sensitivity of parametric oscillators. arXiv, :2412.02887.","ieee":"A. Gu <i>et al.</i>, “Quantum sensitivity of parametric oscillators,” <i>arXiv</i>. ."},"arxiv":1,"article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2412.02887"}],"oa":1,"_id":"21690","date_updated":"2026-04-13T09:52:34Z","article_number":":2412.02887","day":"03","date_created":"2026-04-09T09:10:41Z","scopus_import":"1","abstract":[{"lang":"eng","text":"Many quantum systems exhibit high sensitivity to their initial conditions, where microscopic quantum fluctuations can significantly influence macroscopic observables. Understanding how quantum states may influence the behavior of nonlinear dynamic systems may open new avenues in controlling light-matter interactions. To explore this issue, we analyze the sensitivity of a fundamental quantum optical process - parametric oscillation - to quantum initializations. Focusing on optical parametric oscillators (OPOs), we demonstrate that the quantum statistics of arbitrary initial states are imprinted in the early-stage dynamics and can persist in the steady-state probabilities. We derive the \"quantum sensitivity\" of parametric oscillators, linking the initial quantum state to the system's steady-state outcomes, highlighting how losses and parametric gain govern the system's quantum sensitivity. Moreover, we show that these findings extend beyond OPOs to a broader class of nonlinear systems, including Josephson junction based superconducting circuits. Our work opens the way to a new class of experiments that can test the sensitivity of macroscopic systems to quantum initial conditions and offers a pathway for controlling systems with quantum degrees of freedom."}]},{"month":"12","language":[{"iso":"eng"}],"extern":"1","oa_version":"Preprint","status":"public","publication":"arXiv","OA_place":"repository","external_id":{"arxiv":["2412.15068"]},"citation":{"mla":"Lê, Trung Kiên, et al. “Cavity Quantum Electrodynamics in Finite-Bandwidth Squeezed Reservoir.” <i>ArXiv</i>, 2412.15068, doi:<a href=\"https://doi.org/10.48550/arXiv.2412.15068\">10.48550/arXiv.2412.15068</a>.","ama":"Lê TK, Lukin DM, Roques-Carmes C, et al. Cavity quantum electrodynamics in finite-bandwidth squeezed reservoir. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2412.15068\">10.48550/arXiv.2412.15068</a>","ista":"Lê TK, Lukin DM, Roques-Carmes C, Karnieli A, Lustig E, Guidry MA, Fan S, Vučković J. Cavity quantum electrodynamics in finite-bandwidth squeezed reservoir. arXiv, 2412.15068.","ieee":"T. K. Lê <i>et al.</i>, “Cavity quantum electrodynamics in finite-bandwidth squeezed reservoir,” <i>arXiv</i>. .","apa":"Lê, T. K., Lukin, D. M., Roques-Carmes, C., Karnieli, A., Lustig, E., Guidry, M. A., … Vučković, J. (n.d.). Cavity quantum electrodynamics in finite-bandwidth squeezed reservoir. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2412.15068\">https://doi.org/10.48550/arXiv.2412.15068</a>","chicago":"Lê, Trung Kiên, Daniil M. Lukin, Charles Roques-Carmes, Aviv Karnieli, Eran Lustig, Melissa A. Guidry, Shanhui Fan, and Jelena Vučković. “Cavity Quantum Electrodynamics in Finite-Bandwidth Squeezed Reservoir.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2412.15068\">https://doi.org/10.48550/arXiv.2412.15068</a>.","short":"T.K. Lê, D.M. Lukin, C. Roques-Carmes, A. Karnieli, E. Lustig, M.A. Guidry, S. Fan, J. Vučković, ArXiv (n.d.)."},"article_processing_charge":"No","arxiv":1,"oa":1,"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2412.15068","open_access":"1"}],"_id":"21691","date_updated":"2026-04-13T09:50:09Z","day":"19","article_number":"2412.15068","scopus_import":"1","abstract":[{"text":"Light-matter interaction with squeezed vacuum has received much interest for the ability to enhance the native interaction strength between an atom and a photon with a reservoir assumed to have an infinite bandwidth. Here, we study a model of parametrically driven cavity quantum electrodynamics (cavity QED) for enhancing light-matter interaction while subjected to a finite-bandwidth squeezed vacuum drive. Our method is capable of unveiling the effect of relative bandwidth as well as squeezing required to observe the anticipated anti-crossing spectrum and enhanced cooperativity without the ideal squeezed bath assumption. Furthermore, we analyze the practicality of said models when including intrinsic photon loss due to resonators imperfection. With these results, we outline the requirements for experimentally implementing an effectively squeezed bath in solid-state platforms such as InAs quantum dot cavity QED such that \\textit{in situ} control and enhancement of light-matter interaction could be realized.","lang":"eng"}],"date_created":"2026-04-09T09:10:41Z","year":"2024","OA_type":"green","fulldoi":"https://doi.org/10.48550/arXiv.2412.15068","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"submitted","author":[{"full_name":"Lê, Trung Kiên","last_name":"Lê","first_name":"Trung Kiên"},{"full_name":"Lukin, Daniil M.","first_name":"Daniil M.","last_name":"Lukin"},{"first_name":"Charles","last_name":"Roques-Carmes","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","full_name":"Roques-Carmes, Charles"},{"full_name":"Karnieli, Aviv","last_name":"Karnieli","first_name":"Aviv"},{"first_name":"Eran","last_name":"Lustig","full_name":"Lustig, Eran"},{"full_name":"Guidry, Melissa A.","first_name":"Melissa A.","last_name":"Guidry"},{"full_name":"Fan, Shanhui","last_name":"Fan","first_name":"Shanhui"},{"full_name":"Vučković, Jelena","last_name":"Vučković","first_name":"Jelena"}],"date_published":"2024-12-19T00:00:00Z","type":"preprint","doi":"10.48550/arXiv.2412.15068","title":"Cavity quantum electrodynamics in finite-bandwidth squeezed reservoir"},{"doi":"10.48550/arXiv.2412.21101","title":"Superfluorescent scintillation from coupled perovskite quantum dots","type":"preprint","author":[{"full_name":"Katznelson, Shaul","first_name":"Shaul","last_name":"Katznelson"},{"first_name":"Shai","last_name":"Levy","full_name":"Levy, Shai"},{"full_name":"Gorlach, Alexey","first_name":"Alexey","last_name":"Gorlach"},{"last_name":"Regev","first_name":"Nathan","full_name":"Regev, Nathan"},{"first_name":"Michael","last_name":"Birk","full_name":"Birk, Michael"},{"first_name":"Chen","last_name":"Mechel","full_name":"Mechel, Chen"},{"first_name":"Offek","last_name":"Tziperman","full_name":"Tziperman, Offek"},{"first_name":"Roman","last_name":"Schuetz","full_name":"Schuetz, Roman"},{"last_name":"Strassberg","first_name":"Rotem","full_name":"Strassberg, Rotem"},{"last_name":"Dosovitsky","first_name":"Georgy","full_name":"Dosovitsky, Georgy"},{"last_name":"Roques-Carmes","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","first_name":"Charles","full_name":"Roques-Carmes, Charles"},{"full_name":"Bekenstein, Yehonadav","first_name":"Yehonadav","last_name":"Bekenstein"},{"first_name":"Ido","last_name":"Kaminer","full_name":"Kaminer, Ido"}],"date_published":"2024-12-30T00:00:00Z","publication_status":"submitted","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2024","fulldoi":"https://doi.org/10.48550/arXiv.2412.21101","OA_type":"green","abstract":[{"lang":"eng","text":"Scintillation, the process of converting high-energy radiation to detectable visible light, is pivotal in advanced technologies spanning from medical diagnostics to fundamental scientific research. Despite significant advancements toward faster and more efficient scintillators, there remains a fundamental limit arising from the intrinsic properties of scintillating materials. The scintillation process culminates in spontaneous emission of visible light, which is restricted in rate by the oscillator strength of individual emission centers. Here, we observe a novel collective emission phenomenon under X-ray excitation, breaking this limit and accelerating the emission. Our observation reveals that strong interactions between simultaneously excited coupled perovskite quantum dots can create collective radioluminescence. This effect is characterized by a spectral shift and an enhanced rate of emission, with an average lifetime of 230 ps, 14 times faster than their room temperature spontaneous emission. It has been established that such quantum dots exhibit superfluorescence under UV excitation. However, X-ray superfluorescence is inherently different, as each high-energy photon creates multiple synchronized excitation events, triggered by a photoelectron and resulting in even faster emission rates, a larger spectral shift, and a broader spectrum. This observation is consistent with a quantum-optical analysis explaining both the UV-driven and X-ray-driven effects. We use a Hanbury-Brown-Twiss g^(2) (τ) setup to analyze the temperature-dependent temporal response of these scintillators. Collective radioluminescence breaks the limit of scintillation lifetime based on spontaneous emission and could dramatically improve time-of-flight detector performance, introducing quantum enhancements to scintillation science."}],"date_created":"2026-04-09T09:10:41Z","scopus_import":"1","date_updated":"2026-04-13T09:48:01Z","_id":"21692","day":"30","article_number":"2412.21101","citation":{"chicago":"Katznelson, Shaul, Shai Levy, Alexey Gorlach, Nathan Regev, Michael Birk, Chen Mechel, Offek Tziperman, et al. “Superfluorescent Scintillation from Coupled Perovskite Quantum Dots.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2412.21101\">https://doi.org/10.48550/arXiv.2412.21101</a>.","apa":"Katznelson, S., Levy, S., Gorlach, A., Regev, N., Birk, M., Mechel, C., … Kaminer, I. (n.d.). Superfluorescent scintillation from coupled perovskite quantum dots. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2412.21101\">https://doi.org/10.48550/arXiv.2412.21101</a>","short":"S. Katznelson, S. Levy, A. Gorlach, N. Regev, M. Birk, C. Mechel, O. Tziperman, R. Schuetz, R. Strassberg, G. Dosovitsky, C. Roques-Carmes, Y. Bekenstein, I. Kaminer, ArXiv (n.d.).","mla":"Katznelson, Shaul, et al. “Superfluorescent Scintillation from Coupled Perovskite Quantum Dots.” <i>ArXiv</i>, 2412.21101, doi:<a href=\"https://doi.org/10.48550/arXiv.2412.21101\">10.48550/arXiv.2412.21101</a>.","ista":"Katznelson S, Levy S, Gorlach A, Regev N, Birk M, Mechel C, Tziperman O, Schuetz R, Strassberg R, Dosovitsky G, Roques-Carmes C, Bekenstein Y, Kaminer I. Superfluorescent scintillation from coupled perovskite quantum dots. arXiv, 2412.21101.","ama":"Katznelson S, Levy S, Gorlach A, et al. Superfluorescent scintillation from coupled perovskite quantum dots. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2412.21101\">10.48550/arXiv.2412.21101</a>","ieee":"S. Katznelson <i>et al.</i>, “Superfluorescent scintillation from coupled perovskite quantum dots,” <i>arXiv</i>. ."},"article_processing_charge":"No","arxiv":1,"oa":1,"main_file_link":[{"url":" https://doi.org/10.48550/arXiv.2412.21101","open_access":"1"}],"status":"public","OA_place":"repository","publication":"arXiv","external_id":{"arxiv":["2412.21101"]},"oa_version":"Preprint","month":"12","language":[{"iso":"eng"}],"extern":"1"},{"title":"Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks","doi":"10.1039/d4tc01281j","date_published":"2024-07-10T00:00:00Z","author":[{"first_name":"Minwook","last_name":"Park","full_name":"Park, Minwook"},{"first_name":"Jesus","last_name":"Guillen Campos","full_name":"Guillen Campos, Jesus"},{"full_name":"Stricker, Friedrich J","id":"7aca2cfc-46cf-11f0-abd3-8c96b5186745","last_name":"Stricker","first_name":"Friedrich J"},{"full_name":"Read de Alaniz, Javier","first_name":"Javier","last_name":"Read de Alaniz"}],"publication_status":"published","page":"11976-11981","OA_type":"closed access","intvolume":"        12","date_created":"2026-05-06T10:43:33Z","quality_controlled":"1","date_updated":"2026-05-12T06:50:12Z","_id":"21806","citation":{"chicago":"Park, Minwook, Jesus Guillen Campos, Friedrich J Stricker, and Javier Read de Alaniz. “Photo-Responsive Diels-Alder Based Azobenzene-Functionalized Main-Chain Liquid Crystal Networks.” <i>Journal of Materials Chemistry C</i>. Royal Society of Chemistry, 2024. <a href=\"https://doi.org/10.1039/d4tc01281j\">https://doi.org/10.1039/d4tc01281j</a>.","apa":"Park, M., Guillen Campos, J., Stricker, F. J., &#38; Read de Alaniz, J. (2024). Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks. <i>Journal of Materials Chemistry C</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d4tc01281j\">https://doi.org/10.1039/d4tc01281j</a>","short":"M. Park, J. Guillen Campos, F.J. Stricker, J. Read de Alaniz, Journal of Materials Chemistry C 12 (2024) 11976–11981.","mla":"Park, Minwook, et al. “Photo-Responsive Diels-Alder Based Azobenzene-Functionalized Main-Chain Liquid Crystal Networks.” <i>Journal of Materials Chemistry C</i>, vol. 12, no. 31, Royal Society of Chemistry, 2024, pp. 11976–81, doi:<a href=\"https://doi.org/10.1039/d4tc01281j\">10.1039/d4tc01281j</a>.","ama":"Park M, Guillen Campos J, Stricker FJ, Read de Alaniz J. Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks. <i>Journal of Materials Chemistry C</i>. 2024;12(31):11976-11981. doi:<a href=\"https://doi.org/10.1039/d4tc01281j\">10.1039/d4tc01281j</a>","ista":"Park M, Guillen Campos J, Stricker FJ, Read de Alaniz J. 2024. Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks. Journal of Materials Chemistry C. 12(31), 11976–11981.","ieee":"M. Park, J. Guillen Campos, F. J. Stricker, and J. Read de Alaniz, “Photo-responsive Diels-Alder based azobenzene-functionalized main-chain liquid crystal networks,” <i>Journal of Materials Chemistry C</i>, vol. 12, no. 31. Royal Society of Chemistry, pp. 11976–11981, 2024."},"status":"public","oa_version":"None","extern":"1","language":[{"iso":"eng"}],"type":"journal_article","article_type":"original","issue":"31","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","fulldoi":"https://doi.org/10.1039/d4tc01281j","year":"2024","publication_identifier":{"eissn":["2050-7534"],"issnl":["2050-7526"]},"scopus_import":"1","abstract":[{"lang":"eng","text":"Light-responsive liquid crystal elastomer networks (LCNs) have received significant interest due to their potential application in soft robotics and shape-morphing devices. Here, we present a systematic examination of light-responsive LCNs prepared using a catalyst-free Diels–Alder cycloaddition and a new azobenzene functionalized monomer for main-chain incorporation. The networks have robust mechanical stiffness that can be reversibly modulated by 1 GPa by turning the UV light on and off. This study highlights the contribution of photothermal softening to reversibly control rheological properties of the newly developed LCNs and demonstrates the ability to tune the modulus on demand. We believe this work will guide future developments of light-responsive LCNs based on the newly developed Diels–Alder cycloaddition."}],"day":"10","volume":12,"ddc":["540"],"publisher":"Royal Society of Chemistry","article_processing_charge":"No","publication":"Journal of Materials Chemistry C","month":"07"},{"extern":"1","language":[{"iso":"eng"}],"oa_version":"None","status":"public","citation":{"short":"Y. Yao, A.M. Wilborn, B. Lemaire, F. Trigka, F.J. Stricker, A.H. Weible, S. Li, R.K.A. Bennett, T.C. Cheung, A. Grinthal, M. Zhernenkov, G. Freychet, P. Wąsik, B. Kozinsky, M.M. Lerch, X. Wang, J. Aizenberg, Science 386 (2024) 1161–1168.","chicago":"Yao, Yuxing, Atalaya Milan Wilborn, Baptiste Lemaire, Foteini Trigka, Friedrich J Stricker, Alan H. Weible, Shucong Li, et al. “Programming Liquid Crystal Elastomers for Multistep Ambidirectional Deformability.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.adq6434\">https://doi.org/10.1126/science.adq6434</a>.","apa":"Yao, Y., Wilborn, A. M., Lemaire, B., Trigka, F., Stricker, F. J., Weible, A. H., … Aizenberg, J. (2024). Programming liquid crystal elastomers for multistep ambidirectional deformability. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adq6434\">https://doi.org/10.1126/science.adq6434</a>","ieee":"Y. Yao <i>et al.</i>, “Programming liquid crystal elastomers for multistep ambidirectional deformability,” <i>Science</i>, vol. 386, no. 6726. American Association for the Advancement of Science, pp. 1161–1168, 2024.","ama":"Yao Y, Wilborn AM, Lemaire B, et al. Programming liquid crystal elastomers for multistep ambidirectional deformability. <i>Science</i>. 2024;386(6726):1161-1168. doi:<a href=\"https://doi.org/10.1126/science.adq6434\">10.1126/science.adq6434</a>","ista":"Yao Y, Wilborn AM, Lemaire B, Trigka F, Stricker FJ, Weible AH, Li S, Bennett RKA, Cheung TC, Grinthal A, Zhernenkov M, Freychet G, Wąsik P, Kozinsky B, Lerch MM, Wang X, Aizenberg J. 2024. Programming liquid crystal elastomers for multistep ambidirectional deformability. Science. 386(6726), 1161–1168.","mla":"Yao, Yuxing, et al. “Programming Liquid Crystal Elastomers for Multistep Ambidirectional Deformability.” <i>Science</i>, vol. 386, no. 6726, American Association for the Advancement of Science, 2024, pp. 1161–68, doi:<a href=\"https://doi.org/10.1126/science.adq6434\">10.1126/science.adq6434</a>."},"quality_controlled":"1","_id":"21817","date_updated":"2026-05-12T09:48:12Z","intvolume":"       386","date_created":"2026-05-06T10:54:51Z","OA_type":"closed access","date_published":"2024-12-06T00:00:00Z","publication_status":"published","pmid":1,"author":[{"full_name":"Yao, Yuxing","last_name":"Yao","first_name":"Yuxing"},{"full_name":"Wilborn, Atalaya Milan","last_name":"Wilborn","first_name":"Atalaya Milan"},{"last_name":"Lemaire","first_name":"Baptiste","full_name":"Lemaire, Baptiste"},{"full_name":"Trigka, Foteini","last_name":"Trigka","first_name":"Foteini"},{"first_name":"Friedrich J","id":"7aca2cfc-46cf-11f0-abd3-8c96b5186745","last_name":"Stricker","full_name":"Stricker, Friedrich J"},{"full_name":"Weible, Alan H.","last_name":"Weible","first_name":"Alan H."},{"last_name":"Li","first_name":"Shucong","full_name":"Li, Shucong"},{"full_name":"Bennett, Robert K. A.","last_name":"Bennett","first_name":"Robert K. A."},{"full_name":"Cheung, Tung Chun","first_name":"Tung Chun","last_name":"Cheung"},{"full_name":"Grinthal, Alison","last_name":"Grinthal","first_name":"Alison"},{"full_name":"Zhernenkov, Mikhail","last_name":"Zhernenkov","first_name":"Mikhail"},{"full_name":"Freychet, Guillaume","first_name":"Guillaume","last_name":"Freychet"},{"first_name":"Patryk","last_name":"Wąsik","full_name":"Wąsik, Patryk"},{"first_name":"Boris","last_name":"Kozinsky","full_name":"Kozinsky, Boris"},{"full_name":"Lerch, Michael M.","last_name":"Lerch","first_name":"Michael M."},{"last_name":"Wang","first_name":"Xiaoguang","full_name":"Wang, Xiaoguang"},{"first_name":"Joanna","last_name":"Aizenberg","full_name":"Aizenberg, Joanna"}],"page":"1161-1168","title":"Programming liquid crystal elastomers for multistep ambidirectional deformability","doi":"10.1126/science.adq6434","month":"12","publication":"Science","external_id":{"pmid":["39636998"]},"article_processing_charge":"No","publisher":"American Association for the Advancement of Science","ddc":["540"],"day":"06","volume":386,"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"abstract":[{"lang":"eng","text":"Ambidirectionality, which is the ability of structural elements to move beyond a reference state in two opposite directions, is common in nature. However, conventional soft materials are typically limited to a single, unidirectional deformation unless complex hybrid constructs are used. We exploited the combination of mesogen self-assembly, polymer chain elasticity, and polymerization-induced stress to design liquid crystalline elastomers that exhibit two mesophases: chevron smectic C (cSmC) and smectic A (SmA). Inducing the cSmC-SmA–isotropic phase transition led to an unusual inversion of the strain field in the microstructure, resulting in opposite deformation modes (e.g., consecutive shrinkage or expansion and right-handed or left-handed twisting and tilting in opposite directions) and high-frequency nonmonotonic oscillations. This ambidirectional movement is scalable and can be used to generate Gaussian transformations at the macroscale."}],"scopus_import":"1","fulldoi":"https://doi.org/10.1126/science.adq6434","year":"2024","issue":"6726","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_type":"original","type":"journal_article"},{"date_created":"2026-05-24T08:25:45Z","intvolume":"       300","_id":"21913","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_updated":"2026-06-02T14:52:50Z","quality_controlled":"1","article_number":"107604","citation":{"short":"A. Vogt, M. Szurgot, L. Gardner, D.C. Schultz, R. Marmorstein, Journal of Biological Chemistry 300 (2024).","chicago":"Vogt, Austin, Mary Szurgot, Lauren Gardner, David C. Schultz, and Ronen Marmorstein. “HIRA Complex Deposition of Histone H3.3 Is Driven by Histone Tetramerization and Histone-DNA Binding.” <i>Journal of Biological Chemistry</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.jbc.2024.107604\">https://doi.org/10.1016/j.jbc.2024.107604</a>.","apa":"Vogt, A., Szurgot, M., Gardner, L., Schultz, D. C., &#38; Marmorstein, R. (2024). HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding. <i>Journal of Biological Chemistry</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jbc.2024.107604\">https://doi.org/10.1016/j.jbc.2024.107604</a>","ieee":"A. Vogt, M. Szurgot, L. Gardner, D. C. Schultz, and R. Marmorstein, “HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding,” <i>Journal of Biological Chemistry</i>, vol. 300, no. 9. Elsevier, 2024.","ista":"Vogt A, Szurgot M, Gardner L, Schultz DC, Marmorstein R. 2024. HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding. Journal of Biological Chemistry. 300(9), 107604.","ama":"Vogt A, Szurgot M, Gardner L, Schultz DC, Marmorstein R. HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding. <i>Journal of Biological Chemistry</i>. 2024;300(9). doi:<a href=\"https://doi.org/10.1016/j.jbc.2024.107604\">10.1016/j.jbc.2024.107604</a>","mla":"Vogt, Austin, et al. “HIRA Complex Deposition of Histone H3.3 Is Driven by Histone Tetramerization and Histone-DNA Binding.” <i>Journal of Biological Chemistry</i>, vol. 300, no. 9, 107604, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.jbc.2024.107604\">10.1016/j.jbc.2024.107604</a>."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.jbc.2024.107604"}],"status":"public","oa_version":"Published Version","language":[{"iso":"eng"}],"extern":"1","doi":"10.1016/j.jbc.2024.107604","title":"HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding","pmid":1,"publication_status":"published","author":[{"full_name":"Vogt, Austin","last_name":"Vogt","first_name":"Austin"},{"full_name":"Szurgot, Mary","last_name":"Szurgot","first_name":"Mary"},{"last_name":"Gardner","orcid":"0009-0000-5733-1546","id":"f9dedd98-6d15-11f0-88a5-a7b4143fdec5","first_name":"Lauren","full_name":"Gardner, Lauren"},{"full_name":"Schultz, David C.","last_name":"Schultz","first_name":"David C."},{"last_name":"Marmorstein","first_name":"Ronen","full_name":"Marmorstein, Ronen"}],"date_published":"2024-09-01T00:00:00Z","OA_type":"gold","abstract":[{"lang":"eng","text":"The HIRA histone chaperone complex is comprised of four protein subunits: HIRA, UBN1, CABIN1, and transiently associated ASF1a. All four subunits have been demonstrated to play a role in the deposition of the histone variant H3.3 onto areas of actively transcribed euchromatin in cells. The mechanism by which these subunits function together to drive histone deposition has remained poorly understood. Here we present biochemical and biophysical data supporting a model whereby ASF1a delivers histone H3.3/H4 dimers to the HIRA complex, H3.3/H4 tetramerization drives the association of two HIRA/UBN1 complexes, and the affinity of the histones for DNA drives release of ASF1a and subsequent histone deposition. These findings have implications for understanding how other histone chaperone complexes may mediate histone deposition."}],"publication_identifier":{"issn":["0021-9258"],"eissn":["1083-351X"]},"volume":300,"day":"01","has_accepted_license":"1","ddc":["572"],"acknowledgement":"We would like to acknowledge Elliot Dean and Christina Freeman for technical assistance with recombinant protein expression in insect cells and members of the Marmorstein laboratory for many discussions related to this work. Schematic Figures were created with BioRender.com.","publisher":"Elsevier","article_processing_charge":"Yes","DOAJ_listed":"1","oa":1,"OA_place":"publisher","publication":"Journal of Biological Chemistry","external_id":{"pmid":["39059488"]},"month":"09","type":"journal_article","PlanS_conform":"1","article_type":"original","issue":"9","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2024","fulldoi":"https://doi.org/10.1016/j.jbc.2024.107604"},{"year":"2024","project":[{"name":"The impact of deleterious mutations on small populations","_id":"34d33d68-11ca-11ed-8bc3-ec13763c0ca8","grant_number":"26293"},{"grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program"}],"fulldoi":"https://doi.org/10.1101/2024.10.15.618444","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","type":"preprint","month":"10","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"21918"}]},"publication":"bioRxiv","article_processing_charge":"No","oa":1,"corr_author":"1","acknowledgement":"This work was supported by the Austrian Academy of Science, DOC fellowship No 26293 (K.K.) and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034413 (J.T.). Simulations were performed on the ISTA High-performance Computing Cluster.","day":"18","abstract":[{"text":"Selection against deleterious mutations, called purifying selection, plays a central role in evolution and acts in all populations. It is known that the genetic patterns observed in genomic regions undergoing purifying selection differ from those resulting from neutral evolution. However, a comprehensive understanding of the underlying mechanisms shaping those patterns is still lacking.\r\n\r\nIn the present work, we use simulations combined with a genealogical approach to identify the effect of purifying selection on the ancestry and thus on the genetic diversity. Our analysis relies on the postulate that the genealogy belongs to the universality class of Beta-coalescents. Under this assumption, we derive statistics measuring the distortion of the genealogy. This approach allows us to consider a wide range of regimes (i.e. arbitrary selection and mutation strengths) and uncover a rich phase diagram. We find that, for strong selection, the limiting genealogy is given by Kingman’s coalescent on a polynomial timescale. As selection gets weaker, Muller’s ratchet starts operating, setting off the emergence of multiple mergers in the genealogical structures. Our results show that while multiple-merger coalescents are often interpreted as the signature of selective sweeps in rapidly adapting populations, these structures can also appear in the context of Muller’s ratchet.","lang":"eng"}],"OA_type":"green","publication_status":"draft","author":[{"full_name":"Khudiakova, Kseniia","first_name":"Kseniia","last_name":"Khudiakova","orcid":"0000-0002-6246-1465","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425"},{"last_name":"Boenkost","first_name":"Florin","full_name":"Boenkost, Florin"},{"id":"5dc06dd8-8e51-11ec-9170-8d9c450cc216","last_name":"Tourniaire","first_name":"Julie N","full_name":"Tourniaire, Julie N"}],"date_published":"2024-10-18T00:00:00Z","doi":"10.1101/2024.10.15.618444","title":"Genealogies under purifying selection","language":[{"iso":"eng"}],"oa_version":"Preprint","ec_funded":1,"status":"public","citation":{"mla":"Khudiakova, Kseniia, et al. “Genealogies under Purifying Selection.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2024.10.15.618444\">10.1101/2024.10.15.618444</a>.","ista":"Khudiakova K, Boenkost F, Tourniaire JN. Genealogies under purifying selection. bioRxiv, <a href=\"https://doi.org/10.1101/2024.10.15.618444\">10.1101/2024.10.15.618444</a>.","ama":"Khudiakova K, Boenkost F, Tourniaire JN. Genealogies under purifying selection. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2024.10.15.618444\">10.1101/2024.10.15.618444</a>","ieee":"K. Khudiakova, F. Boenkost, and J. N. Tourniaire, “Genealogies under purifying selection,” <i>bioRxiv</i>. .","chicago":"Khudiakova, Kseniia, Florin Boenkost, and Julie N Tourniaire. “Genealogies under Purifying Selection.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2024.10.15.618444\">https://doi.org/10.1101/2024.10.15.618444</a>.","apa":"Khudiakova, K., Boenkost, F., &#38; Tourniaire, J. N. (n.d.). Genealogies under purifying selection. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2024.10.15.618444\">https://doi.org/10.1101/2024.10.15.618444</a>","short":"K. Khudiakova, F. Boenkost, J.N. Tourniaire, BioRxiv (n.d.)."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2024.10.15.618444"}],"department":[{"_id":"NiBa"},{"_id":"JaMa"}],"date_updated":"2026-06-12T12:43:34Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"_id":"21967","date_created":"2026-06-09T12:14:08Z"},{"doi":"10.1093/brain/awad380","title":"Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders","file_date_updated":"2024-07-16T08:22:13Z","page":"1436-1456","publication_status":"published","pmid":1,"date_published":"2024-04-01T00:00:00Z","author":[{"last_name":"Kaiyrzhanov","first_name":"Rauan","full_name":"Kaiyrzhanov, Rauan"},{"full_name":"Rad, Aboulfazl","first_name":"Aboulfazl","last_name":"Rad"},{"full_name":"Lin, Sheng-Jia","first_name":"Sheng-Jia","last_name":"Lin"},{"last_name":"Bertoli-Avella","first_name":"Aida","full_name":"Bertoli-Avella, Aida"},{"full_name":"Kallemeijn, Wouter W","last_name":"Kallemeijn","first_name":"Wouter W"},{"full_name":"Godwin, Annie","first_name":"Annie","last_name":"Godwin"},{"full_name":"Zaki, Maha S","first_name":"Maha S","last_name":"Zaki"},{"full_name":"Huang, Kevin","id":"3b3d2888-1ff6-11ee-9fa6-8f209ca91fe3","orcid":"0000-0002-2512-7812","last_name":"Huang","first_name":"Kevin"},{"full_name":"Lau, Tracy","first_name":"Tracy","last_name":"Lau"},{"last_name":"Petree","first_name":"Cassidy","full_name":"Petree, Cassidy"},{"full_name":"Efthymiou, Stephanie","last_name":"Efthymiou","first_name":"Stephanie"},{"full_name":"Ghayoor Karimiani, Ehsan","last_name":"Ghayoor Karimiani","first_name":"Ehsan"},{"full_name":"Hempel, Maja","last_name":"Hempel","first_name":"Maja"},{"full_name":"Normand, Elizabeth A","first_name":"Elizabeth A","last_name":"Normand"},{"full_name":"Rudnik-Schöneborn, Sabine","last_name":"Rudnik-Schöneborn","first_name":"Sabine"},{"first_name":"Ulrich A","last_name":"Schatz","full_name":"Schatz, Ulrich A"},{"full_name":"Baggelaar, Marc P","last_name":"Baggelaar","first_name":"Marc P"},{"full_name":"Ilyas, Muhammad","last_name":"Ilyas","first_name":"Muhammad"},{"full_name":"Sultan, Tipu","first_name":"Tipu","last_name":"Sultan"},{"full_name":"Alvi, Javeria Raza","first_name":"Javeria Raza","last_name":"Alvi"},{"last_name":"Ganieva","first_name":"Manizha","full_name":"Ganieva, Manizha"},{"full_name":"Fowler, Ben","last_name":"Fowler","first_name":"Ben"},{"full_name":"Aanicai, Ruxandra","first_name":"Ruxandra","last_name":"Aanicai"},{"full_name":"Akay Tayfun, Gulsen","first_name":"Gulsen","last_name":"Akay Tayfun"},{"last_name":"Al Saman","first_name":"Abdulaziz","full_name":"Al Saman, Abdulaziz"},{"first_name":"Abdulrahman","last_name":"Alswaid","full_name":"Alswaid, 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Mislen","first_name":"Mislen","last_name":"Bauer"},{"first_name":"Peter","last_name":"Bauer","full_name":"Bauer, Peter"},{"full_name":"Beetz, Christian","last_name":"Beetz","first_name":"Christian"},{"full_name":"Garshasbi, Masoud","last_name":"Garshasbi","first_name":"Masoud"},{"full_name":"Hameed Issa, Awatif","last_name":"Hameed Issa","first_name":"Awatif"},{"full_name":"Eyaid, Wafaa","first_name":"Wafaa","last_name":"Eyaid"},{"full_name":"Ahmed, Hind","first_name":"Hind","last_name":"Ahmed"},{"first_name":"Narges","last_name":"Hashemi","full_name":"Hashemi, Narges"},{"first_name":"Kazem","last_name":"Hassanpour","full_name":"Hassanpour, Kazem"},{"first_name":"Isabella","last_name":"Herman","full_name":"Herman, Isabella"},{"full_name":"Ibrohimov, Sherozjon","first_name":"Sherozjon","last_name":"Ibrohimov"},{"full_name":"Abdul-Majeed, Ban A","first_name":"Ban A","last_name":"Abdul-Majeed"},{"last_name":"Imdad","first_name":"Maria","full_name":"Imdad, Maria"},{"last_name":"Isrofilov","first_name":"Maksudjon","full_name":"Isrofilov, Maksudjon"},{"last_name":"Kaiyal","first_name":"Qassem","full_name":"Kaiyal, Qassem"},{"full_name":"Khan, Suliman","first_name":"Suliman","last_name":"Khan"},{"full_name":"Kirmse, Brian","last_name":"Kirmse","first_name":"Brian"},{"full_name":"Koster, Janet","last_name":"Koster","first_name":"Janet"},{"full_name":"Lourenço, Charles Marques","first_name":"Charles Marques","last_name":"Lourenço"},{"full_name":"Mitani, Tadahiro","first_name":"Tadahiro","last_name":"Mitani"},{"last_name":"Moldovan","first_name":"Oana","full_name":"Moldovan, Oana"},{"first_name":"David","last_name":"Murphy","full_name":"Murphy, David"},{"full_name":"Najafi, Maryam","last_name":"Najafi","first_name":"Maryam"},{"full_name":"Pehlivan, Davut","last_name":"Pehlivan","first_name":"Davut"},{"full_name":"Rocha, Maria Eugenia","first_name":"Maria Eugenia","last_name":"Rocha"},{"full_name":"Salpietro, Vincenzo","last_name":"Salpietro","first_name":"Vincenzo"},{"full_name":"Schmidts, Miriam","first_name":"Miriam","last_name":"Schmidts"},{"first_name":"Adel","last_name":"Shalata","full_name":"Shalata, Adel"},{"last_name":"Mahroum","first_name":"Mohammad","full_name":"Mahroum, Mohammad"},{"full_name":"Talbeya, Jawabreh Kassem","last_name":"Talbeya","first_name":"Jawabreh Kassem"},{"full_name":"Taylor, Robert W","last_name":"Taylor","first_name":"Robert W"},{"last_name":"Vazquez","first_name":"Dayana","full_name":"Vazquez, Dayana"},{"full_name":"Vetro, Annalisa","first_name":"Annalisa","last_name":"Vetro"},{"last_name":"Waterham","first_name":"Hans R","full_name":"Waterham, Hans R"},{"full_name":"Zaman, Mashaya","first_name":"Mashaya","last_name":"Zaman"},{"last_name":"Schrader","first_name":"Tina A","full_name":"Schrader, Tina A"},{"last_name":"Chung","first_name":"Wendy K","full_name":"Chung, Wendy K"},{"first_name":"Renzo","last_name":"Guerrini","full_name":"Guerrini, Renzo"},{"full_name":"Lupski, James R","first_name":"James R","last_name":"Lupski"},{"first_name":"Joseph","last_name":"Gleeson","full_name":"Gleeson, Joseph"},{"last_name":"Suri","first_name":"Mohnish","full_name":"Suri, Mohnish"},{"full_name":"Jamshidi, Yalda","last_name":"Jamshidi","first_name":"Yalda"},{"full_name":"Bhatia, Kailash P","first_name":"Kailash P","last_name":"Bhatia"},{"full_name":"Vona, Barbara","last_name":"Vona","first_name":"Barbara"},{"full_name":"Schrader, Michael","first_name":"Michael","last_name":"Schrader"},{"full_name":"Severino, Mariasavina","first_name":"Mariasavina","last_name":"Severino"},{"first_name":"Matthew","last_name":"Guille","full_name":"Guille, Matthew"},{"first_name":"Edward W","last_name":"Tate","full_name":"Tate, Edward W"},{"full_name":"Varshney, Gaurav K","first_name":"Gaurav K","last_name":"Varshney"},{"full_name":"Houlden, Henry","first_name":"Henry","last_name":"Houlden"},{"last_name":"Maroofian","first_name":"Reza","full_name":"Maroofian, Reza"}],"file":[{"date_created":"2024-07-16T08:22:13Z","success":1,"creator":"dernst","checksum":"0ee7a8ab9300225d60968f7a3e3cfa0d","date_updated":"2024-07-16T08:22:13Z","relation":"main_file","content_type":"application/pdf","file_size":2641456,"file_id":"17254","access_level":"open_access","file_name":"2024_Brain_Kaiyrzhanov.pdf"}],"keyword":["Neurology (clinical)"],"date_created":"2023-11-16T12:36:51Z","intvolume":"       147","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_updated":"2024-07-16T08:23:24Z","_id":"14543","quality_controlled":"1","citation":{"short":"R. Kaiyrzhanov, A. Rad, S.-J. Lin, A. Bertoli-Avella, W.W. Kallemeijn, A. Godwin, M.S. Zaki, K. Huang, T. Lau, C. Petree, S. Efthymiou, E. Ghayoor Karimiani, M. Hempel, E.A. Normand, S. Rudnik-Schöneborn, U.A. Schatz, M.P. Baggelaar, M. Ilyas, T. Sultan, J.R. Alvi, M. Ganieva, B. Fowler, R. Aanicai, G. Akay Tayfun, A. Al Saman, A. Alswaid, N. Amiri, N. Asilova, V. Shotelersuk, P. Yeetong, M. Azam, M. Babaei, G. Bahrami Monajemi, P. Mohammadi, S. Samie, S.H. Banu, J.P. Basto, F. Kortüm, M. Bauer, P. Bauer, C. Beetz, M. Garshasbi, A. Hameed Issa, W. Eyaid, H. Ahmed, N. Hashemi, K. Hassanpour, I. Herman, S. Ibrohimov, B.A. Abdul-Majeed, M. Imdad, M. Isrofilov, Q. Kaiyal, S. Khan, B. Kirmse, J. Koster, C.M. Lourenço, T. Mitani, O. Moldovan, D. Murphy, M. Najafi, D. Pehlivan, M.E. Rocha, V. Salpietro, M. Schmidts, A. Shalata, M. Mahroum, J.K. Talbeya, R.W. Taylor, D. Vazquez, A. Vetro, H.R. Waterham, M. Zaman, T.A. Schrader, W.K. Chung, R. Guerrini, J.R. Lupski, J. Gleeson, M. Suri, Y. Jamshidi, K.P. Bhatia, B. Vona, M. Schrader, M. Severino, M. Guille, E.W. Tate, G.K. Varshney, H. Houlden, R. Maroofian, Brain 147 (2024) 1436–1456.","chicago":"Kaiyrzhanov, Rauan, Aboulfazl Rad, Sheng-Jia Lin, Aida Bertoli-Avella, Wouter W Kallemeijn, Annie Godwin, Maha S Zaki, et al. “Bi-Allelic ACBD6 Variants Lead to a Neurodevelopmental Syndrome with Progressive and Complex Movement Disorders.” <i>Brain</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/brain/awad380\">https://doi.org/10.1093/brain/awad380</a>.","apa":"Kaiyrzhanov, R., Rad, A., Lin, S.-J., Bertoli-Avella, A., Kallemeijn, W. W., Godwin, A., … Maroofian, R. (2024). Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. <i>Brain</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/brain/awad380\">https://doi.org/10.1093/brain/awad380</a>","ieee":"R. Kaiyrzhanov <i>et al.</i>, “Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders,” <i>Brain</i>, vol. 147, no. 4. Oxford University Press, pp. 1436–1456, 2024.","ista":"Kaiyrzhanov R, Rad A, Lin S-J, Bertoli-Avella A, Kallemeijn WW, Godwin A, Zaki MS, Huang K, Lau T, Petree C, Efthymiou S, Ghayoor Karimiani E, Hempel M, Normand EA, Rudnik-Schöneborn S, Schatz UA, Baggelaar MP, Ilyas M, Sultan T, Alvi JR, Ganieva M, Fowler B, Aanicai R, Akay Tayfun G, Al Saman A, Alswaid A, Amiri N, Asilova N, Shotelersuk V, Yeetong P, Azam M, Babaei M, Bahrami Monajemi G, Mohammadi P, Samie S, Banu SH, Basto JP, Kortüm F, Bauer M, Bauer P, Beetz C, Garshasbi M, Hameed Issa A, Eyaid W, Ahmed H, Hashemi N, Hassanpour K, Herman I, Ibrohimov S, Abdul-Majeed BA, Imdad M, Isrofilov M, Kaiyal Q, Khan S, Kirmse B, Koster J, Lourenço CM, Mitani T, Moldovan O, Murphy D, Najafi M, Pehlivan D, Rocha ME, Salpietro V, Schmidts M, Shalata A, Mahroum M, Talbeya JK, Taylor RW, Vazquez D, Vetro A, Waterham HR, Zaman M, Schrader TA, Chung WK, Guerrini R, Lupski JR, Gleeson J, Suri M, Jamshidi Y, Bhatia KP, Vona B, Schrader M, Severino M, Guille M, Tate EW, Varshney GK, Houlden H, Maroofian R. 2024. Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. Brain. 147(4), 1436–1456.","ama":"Kaiyrzhanov R, Rad A, Lin S-J, et al. Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. <i>Brain</i>. 2024;147(4):1436-1456. doi:<a href=\"https://doi.org/10.1093/brain/awad380\">10.1093/brain/awad380</a>","mla":"Kaiyrzhanov, Rauan, et al. “Bi-Allelic ACBD6 Variants Lead to a Neurodevelopmental Syndrome with Progressive and Complex Movement Disorders.” <i>Brain</i>, vol. 147, no. 4, Oxford University Press, 2024, pp. 1436–56, doi:<a href=\"https://doi.org/10.1093/brain/awad380\">10.1093/brain/awad380</a>."},"department":[{"_id":"GradSch"}],"status":"public","oa_version":"Submitted Version","language":[{"iso":"eng"}],"extern":"1","type":"journal_article","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"4","year":"2024","fulldoi":"https://doi.org/10.1093/brain/awad380","scopus_import":"1","abstract":[{"text":"The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed, plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function in cells is still unclear, as is the consequence of ACBD6 defects on human pathophysiology. Utilizing exome sequencing and extensive international data sharing efforts, we identified 45 affected individuals from 28 unrelated families (consanguinity 93%) with bi-allelic pathogenic, predominantly loss-of-function (18/20) variants in ACBD6. We generated zebrafish and Xenopus tropicalis acbd6 knockouts by CRISPR/Cas9 and characterized the role of ACBD6 on protein N-myristoylation with YnMyr chemical proteomics in the model organisms and human cells, with the latter also being subjected further to ACBD6 peroxisomal localization studies. The affected individuals (23 males and 22 females), with ages ranging from 1 to 50 years old, typically present with a complex and progressive disease involving moderate-to-severe global developmental delay/intellectual disability (100%) with significant expressive language impairment (98%), movement disorders (97%), facial dysmorphism (95%), and mild cerebellar ataxia (85%) associated with gait impairment (94%), limb spasticity/hypertonia (76%), oculomotor (71%) and behavioural abnormalities (65%), overweight (59%), microcephaly (39%) and epilepsy (33%). The most conspicuous and common movement disorder was dystonia (94%), frequently leading to early-onset progressive postural deformities (97%), limb dystonia (55%), and cervical dystonia (31%). A jerky tremor in the upper limbs (63%), a mild head tremor (59%), parkinsonism/hypokinesia developing with advancing age (32%), and simple motor and vocal tics were among other frequent movement disorders. Midline brain malformations including corpus callosum abnormalities (70%), hypoplasia/agenesis of the anterior commissure (66%), short midbrain and small inferior cerebellar vermis (38% each), as well as hypertrophy of the clava (24%) were common neuroimaging findings. acbd6-deficient zebrafish and Xenopus models effectively recapitulated many clinical phenotypes reported in patients including movement disorders, progressive neuromotor impairment, seizures, microcephaly, craniofacial dysmorphism, and midbrain defects accompanied by developmental delay with increased mortality over time. Unlike ACBD5, ACBD6 did not show a peroxisomal localisation and ACBD6-deficiency was not associated with altered peroxisomal parameters in patient fibroblasts. Significant differences in YnMyr-labelling were observed for 68 co- and 18 post-translationally N-myristoylated proteins in patient-derived fibroblasts. N-Myristoylation was similarly affected in acbd6-deficient zebrafish and Xenopus tropicalis models, including Fus, Marcks, and Chchd-related proteins implicated in neurological diseases. The present study provides evidence that bi-allelic pathogenic variants in ACBD6 lead to a distinct neurodevelopmental syndrome accompanied by complex and progressive cognitive and movement disorders.","lang":"eng"}],"publication_identifier":{"issn":["0006-8950"],"eissn":["1460-2156"]},"volume":147,"day":"01","has_accepted_license":"1","ddc":["570"],"publisher":"Oxford University Press","article_processing_charge":"No","oa":1,"publication":"Brain","external_id":{"pmid":["37951597"]},"month":"04"},{"day":"01","volume":36,"publication_identifier":{"eissn":["1532-298X"],"issn":["1040-4651"]},"scopus_import":"1","abstract":[{"lang":"eng","text":"Autocrine signaling pathways regulated by RAPID ALKALINIZATION FACTORs (RALFs) control cell wall integrity during pollen tube germination and growth in Arabidopsis (Arabidopsis thaliana). To investigate the role of pollen-specific RALFs in another plant species, we combined gene expression data with phylogenetic and biochemical studies to identify candidate orthologs in maize (Zea mays). We show that Clade IB ZmRALF2/3 mutations, but not Clade III ZmRALF1/5 mutations, cause cell wall instability in the sub-apical region of the growing pollen tube. ZmRALF2/3 are mainly located in the cell wall and are partially able to complement the pollen germination defect of their Arabidopsis orthologs AtRALF4/19. Mutations in ZmRALF2/3 compromise pectin distribution patterns leading to altered cell wall organization and thickness culminating in pollen tube burst. Clade IB, but not Clade III ZmRALFs, strongly interact as ligands with the pollen-specific Catharanthus roseus RLK1-like (CrRLK1L) receptor kinases Zea mays FERONIA-like (ZmFERL) 4/7/9, LORELEI-like glycosylphosphatidylinositol-anchor (LLG) proteins Zea mays LLG 1 and 2 (ZmLLG1/2) and Zea mays pollen extension-like (PEX) cell wall proteins ZmPEX2/4. Notably, ZmFERL4 outcompetes ZmLLG2 and ZmPEX2 outcompetes ZmFERL4 for ZmRALF2 binding. Based on these data, we suggest that Clade IB RALFs act in a dual role as cell wall components and extracellular sensors to regulate cell wall integrity and thickness during pollen tube growth in maize and probably other plants."}],"publisher":"Oxford University Press","ddc":["580"],"has_accepted_license":"1","external_id":{"pmid":["38142229"]},"publication":"The Plant Cell","oa":1,"article_processing_charge":"No","month":"05","type":"journal_article","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"5","fulldoi":"https://doi.org/10.1093/plcell/koad324","year":"2024","article_number":"koad324","quality_controlled":"1","_id":"14726","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"date_updated":"2024-07-16T11:18:46Z","intvolume":"        36","date_created":"2024-01-02T11:19:37Z","status":"public","main_file_link":[{"url":"https://doi.org/10.1093/plcell/koad324","open_access":"1"}],"citation":{"ista":"Zhou L-Z, Wang L, Chen X, Ge Z, Mergner J, Li X, Küster B, Längst G, Qu L-J, Dresselhaus T. 2024. The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. The Plant Cell. 36(5), koad324.","ama":"Zhou L-Z, Wang L, Chen X, et al. The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. <i>The Plant Cell</i>. 2024;36(5). doi:<a href=\"https://doi.org/10.1093/plcell/koad324\">10.1093/plcell/koad324</a>","mla":"Zhou, Liang-Zi, et al. “The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize.” <i>The Plant Cell</i>, vol. 36, no. 5, koad324, Oxford University Press, 2024, doi:<a href=\"https://doi.org/10.1093/plcell/koad324\">10.1093/plcell/koad324</a>.","ieee":"L.-Z. Zhou <i>et al.</i>, “The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize,” <i>The Plant Cell</i>, vol. 36, no. 5. Oxford University Press, 2024.","chicago":"Zhou, Liang-Zi, Lele Wang, Xia Chen, Zengxiang Ge, Julia Mergner, Xingli Li, Bernhard Küster, Gernot Längst, Li-Jia Qu, and Thomas Dresselhaus. “The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize.” <i>The Plant Cell</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/plcell/koad324\">https://doi.org/10.1093/plcell/koad324</a>.","apa":"Zhou, L.-Z., Wang, L., Chen, X., Ge, Z., Mergner, J., Li, X., … Dresselhaus, T. (2024). The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize. <i>The Plant Cell</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/plcell/koad324\">https://doi.org/10.1093/plcell/koad324</a>","short":"L.-Z. Zhou, L. Wang, X. Chen, Z. Ge, J. Mergner, X. Li, B. Küster, G. Längst, L.-J. Qu, T. Dresselhaus, The Plant Cell 36 (2024)."},"extern":"1","language":[{"iso":"eng"}],"oa_version":"Published Version","title":"The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize","doi":"10.1093/plcell/koad324","keyword":["Cell Biology","Plant Science"],"author":[{"full_name":"Zhou, Liang-Zi","first_name":"Liang-Zi","last_name":"Zhou"},{"first_name":"Lele","last_name":"Wang","full_name":"Wang, Lele"},{"last_name":"Chen","first_name":"Xia","full_name":"Chen, Xia"},{"last_name":"Ge","orcid":"0000-0001-9381-3577","id":"f43371a3-09ff-11eb-8013-bd0c6a2f6de8","first_name":"Zengxiang","full_name":"Ge, Zengxiang"},{"full_name":"Mergner, Julia","first_name":"Julia","last_name":"Mergner"},{"last_name":"Li","first_name":"Xingli","full_name":"Li, Xingli"},{"last_name":"Küster","first_name":"Bernhard","full_name":"Küster, Bernhard"},{"first_name":"Gernot","last_name":"Längst","full_name":"Längst, Gernot"},{"full_name":"Qu, Li-Jia","last_name":"Qu","first_name":"Li-Jia"},{"full_name":"Dresselhaus, Thomas","last_name":"Dresselhaus","first_name":"Thomas"}],"date_published":"2024-05-01T00:00:00Z","publication_status":"published","pmid":1},{"publisher":"Oxford University Press","publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]},"scopus_import":"1","abstract":[{"lang":"eng","text":"Cataclysmic variables (CVs) that have evolved past the period minimum during their lifetimes are predicted to be systems with a brown dwarf donor. While population synthesis models predict that around 40–70 per cent of the Galactic CVs are post-period minimum systems referred to as ‘period bouncers’, only a few dozen confirmed systems are known. We report the study and characterization of a new eclipsing CV, SRGeJ041130.3+685350 (SRGeJ0411), discovered from a joint SRG/eROSITA and ZTF programme. The optical spectrum of SRGeJ0411 shows prominent hydrogen and helium emission lines, typical for CVs. We obtained optical high-speed photometry to confirm the eclipse of SRGeJ0411 and determine the orbital period to be Porb ≈ 97.530 min. The spectral energy distribution suggests that the donor has an effective temperature of ≲ 1800 K. We constrain the donor mass with the period–density relationship for Roche lobe-filling stars and find that Mdonor ≲ 0.04 M⊙. The binary parameters are consistent with evolutionary models for post-period minimum CVs, suggesting that SRGeJ0411 is a new period bouncer. The optical emission lines of SRGeJ0411 are single-peaked despite the system being eclipsing, which is typically only seen due to stream-fed accretion in polars. X-ray spectroscopy hints that the white dwarf in SRGeJ0411 could be magnetic, but verifying the magnetic nature of SRGeJ0411 requires further investigation. The lack of optical outbursts has made SRGeJ0411 elusive in previous surveys, and joint X-ray and optical surveys highlight the potential for discovering similar systems in the near future."}],"day":"04","volume":528,"month":"01","oa":1,"arxiv":1,"article_processing_charge":"No","external_id":{"arxiv":["2401.04178"]},"publication":"Monthly Notices of the Royal Astronomical Society","article_type":"original","type":"journal_article","fulldoi":"https://doi.org/10.1093/mnras/stae012","year":"2024","issue":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"       528","date_created":"2024-03-26T09:43:55Z","quality_controlled":"1","_id":"15189","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_updated":"2024-04-02T06:50:01Z","oa_version":"Published Version","extern":"1","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1093/mnras/stae012","open_access":"1"}],"citation":{"ama":"Galiullin I, Rodriguez AC, Kulkarni SR, et al. A joint SRG/eROSITA + ZTF search: Discovery of a 97-min period eclipsing cataclysmic variable with evidence of a brown dwarf secondary. <i>Monthly Notices of the Royal Astronomical Society</i>. 2024;528(1):676-692. doi:<a href=\"https://doi.org/10.1093/mnras/stae012\">10.1093/mnras/stae012</a>","ista":"Galiullin I, Rodriguez AC, Kulkarni SR, Sunyaev R, Gilfanov M, Bikmaev I, Yungelson L, van Roestel J, Gänsicke BT, Khamitov I, Szkody P, El-Badry K, Suslikov M, Prince TA, Buntov M, Caiazzo I, Gorbachev M, Graham MJ, Gumerov R, Irtuganov E, Laher RR, Medvedev P, Riddle R, Rusholme B, Sakhibullin N, Sklyanov A, Vanderbosch ZP. 2024. A joint SRG/eROSITA + ZTF search: Discovery of a 97-min period eclipsing cataclysmic variable with evidence of a brown dwarf secondary. Monthly Notices of the Royal Astronomical Society. 528(1), 676–692.","mla":"Galiullin, Ilkham, et al. “A Joint SRG/EROSITA + ZTF Search: Discovery of a 97-Min Period Eclipsing Cataclysmic Variable with Evidence of a Brown Dwarf Secondary.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 528, no. 1, Oxford University Press, 2024, pp. 676–92, doi:<a href=\"https://doi.org/10.1093/mnras/stae012\">10.1093/mnras/stae012</a>.","ieee":"I. Galiullin <i>et al.</i>, “A joint SRG/eROSITA + ZTF search: Discovery of a 97-min period eclipsing cataclysmic variable with evidence of a brown dwarf secondary,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 528, no. 1. Oxford University Press, pp. 676–692, 2024.","chicago":"Galiullin, Ilkham, Antonio C Rodriguez, Shrinivas R Kulkarni, Rashid Sunyaev, Marat Gilfanov, Ilfan Bikmaev, Lev Yungelson, et al. “A Joint SRG/EROSITA + ZTF Search: Discovery of a 97-Min Period Eclipsing Cataclysmic Variable with Evidence of a Brown Dwarf Secondary.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/mnras/stae012\">https://doi.org/10.1093/mnras/stae012</a>.","apa":"Galiullin, I., Rodriguez, A. C., Kulkarni, S. R., Sunyaev, R., Gilfanov, M., Bikmaev, I., … Vanderbosch, Z. P. (2024). A joint SRG/eROSITA + ZTF search: Discovery of a 97-min period eclipsing cataclysmic variable with evidence of a brown dwarf secondary. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stae012\">https://doi.org/10.1093/mnras/stae012</a>","short":"I. Galiullin, A.C. Rodriguez, S.R. Kulkarni, R. Sunyaev, M. Gilfanov, I. Bikmaev, L. Yungelson, J. van Roestel, B.T. Gänsicke, I. Khamitov, P. Szkody, K. El-Badry, M. Suslikov, T.A. Prince, M. Buntov, I. Caiazzo, M. Gorbachev, M.J. Graham, R. Gumerov, E. Irtuganov, R.R. Laher, P. Medvedev, R. Riddle, B. Rusholme, N. Sakhibullin, A. Sklyanov, Z.P. Vanderbosch, Monthly Notices of the Royal Astronomical Society 528 (2024) 676–692."},"status":"public","publication_status":"published","date_published":"2024-01-04T00:00:00Z","author":[{"full_name":"Galiullin, Ilkham","last_name":"Galiullin","first_name":"Ilkham"},{"last_name":"Rodriguez","first_name":"Antonio C","full_name":"Rodriguez, Antonio C"},{"first_name":"Shrinivas R","last_name":"Kulkarni","full_name":"Kulkarni, Shrinivas R"},{"first_name":"Rashid","last_name":"Sunyaev","full_name":"Sunyaev, Rashid"},{"full_name":"Gilfanov, Marat","last_name":"Gilfanov","first_name":"Marat"},{"first_name":"Ilfan","last_name":"Bikmaev","full_name":"Bikmaev, Ilfan"},{"last_name":"Yungelson","first_name":"Lev","full_name":"Yungelson, Lev"},{"full_name":"van Roestel, Jan","first_name":"Jan","last_name":"van Roestel"},{"full_name":"Gänsicke, Boris T","last_name":"Gänsicke","first_name":"Boris T"},{"full_name":"Khamitov, Irek","first_name":"Irek","last_name":"Khamitov"},{"last_name":"Szkody","first_name":"Paula","full_name":"Szkody, Paula"},{"last_name":"El-Badry","first_name":"Kareem","full_name":"El-Badry, Kareem"},{"last_name":"Suslikov","first_name":"Mikhail","full_name":"Suslikov, Mikhail"},{"full_name":"Prince, Thomas A","first_name":"Thomas A","last_name":"Prince"},{"last_name":"Buntov","first_name":"Mikhail","full_name":"Buntov, Mikhail"},{"full_name":"Caiazzo, Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","last_name":"Caiazzo","orcid":"0000-0002-4770-5388","first_name":"Ilaria"},{"last_name":"Gorbachev","first_name":"Mark","full_name":"Gorbachev, Mark"},{"first_name":"Matthew J","last_name":"Graham","full_name":"Graham, Matthew J"},{"last_name":"Gumerov","first_name":"Rustam","full_name":"Gumerov, Rustam"},{"last_name":"Irtuganov","first_name":"Eldar","full_name":"Irtuganov, Eldar"},{"full_name":"Laher, Russ R","first_name":"Russ R","last_name":"Laher"},{"full_name":"Medvedev, Pavel","first_name":"Pavel","last_name":"Medvedev"},{"full_name":"Riddle, Reed","last_name":"Riddle","first_name":"Reed"},{"last_name":"Rusholme","first_name":"Ben","full_name":"Rusholme, Ben"},{"first_name":"Nail","last_name":"Sakhibullin","full_name":"Sakhibullin, Nail"},{"full_name":"Sklyanov, Alexander","first_name":"Alexander","last_name":"Sklyanov"},{"full_name":"Vanderbosch, Zachary P","first_name":"Zachary P","last_name":"Vanderbosch"}],"page":"676-692","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"title":"A joint SRG/eROSITA + ZTF search: Discovery of a 97-min period eclipsing cataclysmic variable with evidence of a brown dwarf secondary","doi":"10.1093/mnras/stae012"},{"publisher":"American Astronomical Society","day":"22","volume":961,"publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"abstract":[{"text":"Despite their shared origin, members of globular clusters display star-to-star variations in composition. The observed pattern of element abundances is unique to these stellar environments and cannot be fully explained by any proposed mechanism. It remains unclear whether stars form with chemical heterogeneity or inherit it from interactions with other members. These scenarios may be differentiated by the dependence of chemical spread on stellar mass; however, obtaining a sufficiently large mass baseline requires abundance measurements on the lower main sequence, which is too faint for spectroscopy even in the nearest globular clusters. We developed a stellar modeling method to obtain precise chemical abundances for stars near the end of the main sequence from multiband photometry, and we applied it to the globular cluster 47 Tucanae. The computational efficiency is attained by matching chemical elements to the model components that are most sensitive to their abundance. We determined [O/Fe] for ∼5000 members below the main-sequence knee at the level of accuracy, comparable to the spectroscopic measurements of evolved members in the literature. The inferred distribution disfavors stellar interactions as the origin of chemical spread; however, an accurate theory of accretion is required to draw a more definitive conclusion. We anticipate that future observations of 47 Tucanae with the James Webb Space Telescope will extend the mass baseline of our analysis into the substellar regime. Therefore, we present predicted color–magnitude diagrams and mass–magnitude relations for the brown dwarf members of 47 Tucanae.","lang":"eng"}],"scopus_import":"1","month":"01","publication":"The Astrophysical Journal","external_id":{"arxiv":["2310.11800"]},"oa":1,"article_processing_charge":"No","arxiv":1,"article_type":"original","type":"journal_article","fulldoi":"https://doi.org/10.3847/1538-4357/ad08bf","year":"2024","issue":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_number":"139","quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_updated":"2024-04-02T06:52:43Z","_id":"15191","intvolume":"       961","date_created":"2024-03-26T09:44:50Z","extern":"1","language":[{"iso":"eng"}],"oa_version":"Published Version","status":"public","main_file_link":[{"url":"https://doi.org/10.3847/1538-4357/ad08bf","open_access":"1"}],"citation":{"ieee":"R. Gerasimov <i>et al.</i>, “Exploring the chemistry and mass function of the globular cluster 47 Tucanae with new theoretical color–magnitude diagrams,” <i>The Astrophysical Journal</i>, vol. 961, no. 1. American Astronomical Society, 2024.","ama":"Gerasimov R, Burgasser AJ, Caiazzo I, et al. Exploring the chemistry and mass function of the globular cluster 47 Tucanae with new theoretical color–magnitude diagrams. <i>The Astrophysical Journal</i>. 2024;961(1). doi:<a href=\"https://doi.org/10.3847/1538-4357/ad08bf\">10.3847/1538-4357/ad08bf</a>","ista":"Gerasimov R, Burgasser AJ, Caiazzo I, Homeier D, Richer HB, Correnti M, Heyl J. 2024. Exploring the chemistry and mass function of the globular cluster 47 Tucanae with new theoretical color–magnitude diagrams. The Astrophysical Journal. 961(1), 139.","mla":"Gerasimov, Roman, et al. “Exploring the Chemistry and Mass Function of the Globular Cluster 47 Tucanae with New Theoretical Color–Magnitude Diagrams.” <i>The Astrophysical Journal</i>, vol. 961, no. 1, 139, American Astronomical Society, 2024, doi:<a href=\"https://doi.org/10.3847/1538-4357/ad08bf\">10.3847/1538-4357/ad08bf</a>.","short":"R. Gerasimov, A.J. Burgasser, I. Caiazzo, D. Homeier, H.B. Richer, M. Correnti, J. Heyl, The Astrophysical Journal 961 (2024).","chicago":"Gerasimov, Roman, Adam J. Burgasser, Ilaria Caiazzo, Derek Homeier, Harvey B. Richer, Matteo Correnti, and Jeremy Heyl. “Exploring the Chemistry and Mass Function of the Globular Cluster 47 Tucanae with New Theoretical Color–Magnitude Diagrams.” <i>The Astrophysical Journal</i>. American Astronomical Society, 2024. <a href=\"https://doi.org/10.3847/1538-4357/ad08bf\">https://doi.org/10.3847/1538-4357/ad08bf</a>.","apa":"Gerasimov, R., Burgasser, A. J., Caiazzo, I., Homeier, D., Richer, H. B., Correnti, M., &#38; Heyl, J. (2024). Exploring the chemistry and mass function of the globular cluster 47 Tucanae with new theoretical color–magnitude diagrams. <i>The Astrophysical Journal</i>. American Astronomical Society. <a href=\"https://doi.org/10.3847/1538-4357/ad08bf\">https://doi.org/10.3847/1538-4357/ad08bf</a>"},"keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"author":[{"last_name":"Gerasimov","first_name":"Roman","full_name":"Gerasimov, Roman"},{"full_name":"Burgasser, Adam J.","first_name":"Adam J.","last_name":"Burgasser"},{"full_name":"Caiazzo, Ilaria","first_name":"Ilaria","orcid":"0000-0002-4770-5388","last_name":"Caiazzo","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d"},{"last_name":"Homeier","first_name":"Derek","full_name":"Homeier, Derek"},{"full_name":"Richer, Harvey B.","last_name":"Richer","first_name":"Harvey B."},{"full_name":"Correnti, Matteo","first_name":"Matteo","last_name":"Correnti"},{"full_name":"Heyl, Jeremy","last_name":"Heyl","first_name":"Jeremy"}],"publication_status":"published","date_published":"2024-01-22T00:00:00Z","title":"Exploring the chemistry and mass function of the globular cluster 47 Tucanae with new theoretical color–magnitude diagrams","doi":"10.3847/1538-4357/ad08bf"},{"OA_type":"hybrid","file":[{"content_type":"application/pdf","file_size":775825,"relation":"main_file","checksum":"dc8be74156657e8aab12a9d613233ee3","date_updated":"2025-01-09T09:31:05Z","creator":"dernst","success":1,"date_created":"2025-01-09T09:31:05Z","file_name":"2024_BioEssays_Stockwell.pdf","access_level":"open_access","file_id":"18801"}],"pmid":1,"publication_status":"published","author":[{"full_name":"Stockwell, Imogen","first_name":"Imogen","last_name":"Stockwell"},{"full_name":"Watson, Jake","first_name":"Jake","orcid":"0000-0002-8698-3823","last_name":"Watson","id":"63836096-4690-11EA-BD4E-32803DDC885E"},{"full_name":"Greger, Ingo H.","last_name":"Greger","first_name":"Ingo H."}],"date_published":"2024-07-01T00:00:00Z","isi":1,"file_date_updated":"2025-01-09T09:31:05Z","title":"Tuning synaptic strength by regulation of AMPA glutamate receptor localization","doi":"10.1002/bies.202400006","oa_version":"Published Version","language":[{"iso":"eng"}],"department":[{"_id":"PeJo"}],"citation":{"mla":"Stockwell, Imogen, et al. “Tuning Synaptic Strength by Regulation of AMPA Glutamate Receptor Localization.” <i>BioEssays</i>, vol. 46, no. 7, 2400006, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/bies.202400006\">10.1002/bies.202400006</a>.","ama":"Stockwell I, Watson J, Greger IH. Tuning synaptic strength by regulation of AMPA glutamate receptor localization. <i>BioEssays</i>. 2024;46(7). doi:<a href=\"https://doi.org/10.1002/bies.202400006\">10.1002/bies.202400006</a>","ista":"Stockwell I, Watson J, Greger IH. 2024. Tuning synaptic strength by regulation of AMPA glutamate receptor localization. BioEssays. 46(7), 2400006.","ieee":"I. Stockwell, J. Watson, and I. H. Greger, “Tuning synaptic strength by regulation of AMPA glutamate receptor localization,” <i>BioEssays</i>, vol. 46, no. 7. Wiley, 2024.","chicago":"Stockwell, Imogen, Jake Watson, and Ingo H. Greger. “Tuning Synaptic Strength by Regulation of AMPA Glutamate Receptor Localization.” <i>BioEssays</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/bies.202400006\">https://doi.org/10.1002/bies.202400006</a>.","apa":"Stockwell, I., Watson, J., &#38; Greger, I. H. (2024). Tuning synaptic strength by regulation of AMPA glutamate receptor localization. <i>BioEssays</i>. Wiley. <a href=\"https://doi.org/10.1002/bies.202400006\">https://doi.org/10.1002/bies.202400006</a>","short":"I. Stockwell, J. Watson, I.H. Greger, BioEssays 46 (2024)."},"status":"public","intvolume":"        46","date_created":"2024-05-12T22:01:02Z","quality_controlled":"1","article_number":" 2400006","date_updated":"2025-09-08T07:25:02Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"_id":"15379","fulldoi":"https://doi.org/10.1002/bies.202400006","year":"2024","issue":"7","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_type":"review","type":"journal_article","month":"07","oa":1,"article_processing_charge":"Yes (in subscription journal)","OA_place":"publisher","publication":"BioEssays","external_id":{"isi":["001214545700001"],"pmid":["38693811"]},"acknowledgement":"The authors thank Alexander Scrutton and James M. Krieger for comments on the manuscript. The authors also acknowledge Shraddha Nayak for help with Figure 1B design. This work was supported by grants from the Medical Research Council (MC_U105174197), the BBSRC (BB/N002113/1), and the Wellcome Trust (223194/Z/21/Z) to IHG.","has_accepted_license":"1","ddc":["570"],"publisher":"Wiley","publication_identifier":{"eissn":["1521-1878"],"issn":["0265-9247"]},"abstract":[{"lang":"eng","text":"Long-term potentiation (LTP) of excitatory synapses is a leading model to explain the concept of information storage in the brain. Multiple mechanisms contribute to LTP, but central amongst them is an increased sensitivity of the postsynaptic membrane to neurotransmitter release. This sensitivity is predominantly determined by the abundance and localization of AMPA-type glutamate receptors (AMPARs). A combination of AMPAR structural data, super-resolution imaging of excitatory synapses, and an abundance of electrophysiological studies are providing an ever-clearer picture of how AMPARs are recruited and organized at synaptic junctions. Here, we review the latest insights into this process, and discuss how both cytoplasmic and extracellular receptor elements cooperate to tune the AMPAR response at the hippocampal CA1 synapse."}],"scopus_import":"1","day":"01","volume":46},{"type":"research_data","file_date_updated":"2024-05-22T12:17:10Z","title":"Raw data to \"MAS NMR experiments of corynebacterial cell walls: complementary 1H- and CPMAS CryoProbe-enhanced 13C-detected experiments\"","doi":"10.15479/AT:ISTA:17042","keyword":["nuclear magnetic resonance","NMR","cellwall","structural biology","spectroscopy"],"file":[{"content_type":"text/plain","file_size":2132,"relation":"main_file","date_updated":"2024-05-22T12:05:13Z","checksum":"eb55f0988342d927702353b75e07edfa","creator":"pschanda","date_created":"2024-05-22T12:05:13Z","success":1,"file_name":"Read_me.txt","access_level":"open_access","file_id":"17043"},{"file_id":"17044","access_level":"open_access","file_name":"raw_data_CryoMAS_cyronebacteria.zip","creator":"pschanda","success":1,"date_created":"2024-05-22T12:17:10Z","relation":"main_file","checksum":"3393592acaf5ee1e032052c236780914","date_updated":"2024-05-22T12:17:10Z","content_type":"application/zip","file_size":755704888}],"date_published":"2024-05-22T00:00:00Z","author":[{"first_name":"Paul","last_name":"Schanda","orcid":"0000-0002-9350-7606","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","fulldoi":"https://doi.org/10.15479/AT:ISTA:17042","year":"2024","day":"22","_id":"17042","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"date_updated":"2025-09-09T12:01:41Z","abstract":[{"text":"Bacterial cell walls are gigadalton-large cross-linked polymers with a wide range of motional amplitudes, including rather rigid as well as highly flexible parts. Magic-angle spinning NMR is a powerful method to obtain atomic-level information about intact cell walls. Here we investigate sensitivity and information content of different homonuclear 13C-13C and heteronuclear H-N, H-C and N-C correlation experiments. We demonstrate that a CPMAS CryoProbe yields ca. 8-fold increased signal-to-noise over a room-temperature probe, or a ca. 3-4-fold larger per-mass sensitivity. The increased sensitivity allowed to obtain high-resolution spectra even on intact bacteria. Moreover, we compare resolution and sensitivity of 1H MAS experiments obtained at 100 kHz vs. 55 kHz. Our study provides useful hints for choosing experiments to extract atomic-level details on cell-wall samples. ","lang":"eng"}],"date_created":"2024-05-22T12:04:54Z","corr_author":"1","publisher":"Institute of Science and Technology Austria","ddc":["570"],"has_accepted_license":"1","status":"public","oa":1,"department":[{"_id":"PaSc"}],"citation":{"short":"P. Schanda, (2024).","chicago":"Schanda, Paul. “Raw Data to ‘MAS NMR Experiments of Corynebacterial Cell Walls: Complementary 1H- and CPMAS CryoProbe-Enhanced 13C-Detected Experiments.’” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:17042\">https://doi.org/10.15479/AT:ISTA:17042</a>.","apa":"Schanda, P. (2024). Raw data to “MAS NMR experiments of corynebacterial cell walls: complementary 1H- and CPMAS CryoProbe-enhanced 13C-detected experiments.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:17042\">https://doi.org/10.15479/AT:ISTA:17042</a>","ieee":"P. Schanda, “Raw data to ‘MAS NMR experiments of corynebacterial cell walls: complementary 1H- and CPMAS CryoProbe-enhanced 13C-detected experiments.’” Institute of Science and Technology Austria, 2024.","mla":"Schanda, Paul. <i>Raw Data to “MAS NMR Experiments of Corynebacterial Cell Walls: Complementary 1H- and CPMAS CryoProbe-Enhanced 13C-Detected Experiments.”</i> Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:17042\">10.15479/AT:ISTA:17042</a>.","ista":"Schanda P. 2024. Raw data to ‘MAS NMR experiments of corynebacterial cell walls: complementary 1H- and CPMAS CryoProbe-enhanced 13C-detected experiments’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:17042\">10.15479/AT:ISTA:17042</a>.","ama":"Schanda P. Raw data to “MAS NMR experiments of corynebacterial cell walls: complementary 1H- and CPMAS CryoProbe-enhanced 13C-detected experiments.” 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:17042\">10.15479/AT:ISTA:17042</a>"},"article_processing_charge":"No","related_material":{"record":[{"id":"17291","status":"public","relation":"used_in_publication"}]},"contributor":[{"contributor_type":"data_collector","first_name":"Alicia","last_name":"Vallet"},{"first_name":"Isabel ","last_name":"Ayala","contributor_type":"data_collector"},{"first_name":"Barbara","last_name":"Perrone","contributor_type":"data_collector"},{"contributor_type":"data_collector","first_name":"Alia","last_name":"Hassan"},{"contributor_type":"data_collector","last_name":"Bougault","first_name":"Catherine"}],"month":"05","oa_version":"Published Version"},{"intvolume":"       123","date_created":"2024-06-04T06:41:03Z","quality_controlled":"1","_id":"17111","date_updated":"2025-01-13T11:03:41Z","oa_version":"None","extern":"1","language":[{"iso":"eng"}],"citation":{"apa":"Kamatar, A., Bravo, J. P. K., Yuan, F., Wang, L., Lafer, E. M., Taylor, D. W., … Parekh, S. H. (2024). Lipid droplets as substrates for protein phase separation. <i>Biophysical Journal</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.bpj.2024.03.015\">https://doi.org/10.1016/j.bpj.2024.03.015</a>","chicago":"Kamatar, Advika, Jack Peter Kelly Bravo, Feng Yuan, Liping Wang, Eileen M. Lafer, David W. Taylor, Jeanne C. Stachowiak, and Sapun H. Parekh. “Lipid Droplets as Substrates for Protein Phase Separation.” <i>Biophysical Journal</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.bpj.2024.03.015\">https://doi.org/10.1016/j.bpj.2024.03.015</a>.","short":"A. Kamatar, J.P.K. Bravo, F. Yuan, L. Wang, E.M. Lafer, D.W. Taylor, J.C. Stachowiak, S.H. Parekh, Biophysical Journal 123 (2024) 1494–1507.","mla":"Kamatar, Advika, et al. “Lipid Droplets as Substrates for Protein Phase Separation.” <i>Biophysical Journal</i>, vol. 123, no. 11, Elsevier, 2024, pp. 1494–507, doi:<a href=\"https://doi.org/10.1016/j.bpj.2024.03.015\">10.1016/j.bpj.2024.03.015</a>.","ista":"Kamatar A, Bravo JPK, Yuan F, Wang L, Lafer EM, Taylor DW, Stachowiak JC, Parekh SH. 2024. Lipid droplets as substrates for protein phase separation. Biophysical Journal. 123(11), 1494–1507.","ama":"Kamatar A, Bravo JPK, Yuan F, et al. Lipid droplets as substrates for protein phase separation. <i>Biophysical Journal</i>. 2024;123(11):1494-1507. doi:<a href=\"https://doi.org/10.1016/j.bpj.2024.03.015\">10.1016/j.bpj.2024.03.015</a>","ieee":"A. Kamatar <i>et al.</i>, “Lipid droplets as substrates for protein phase separation,” <i>Biophysical Journal</i>, vol. 123, no. 11. Elsevier, pp. 1494–1507, 2024."},"status":"public","pmid":1,"date_published":"2024-06-04T00:00:00Z","publication_status":"published","author":[{"first_name":"Advika","last_name":"Kamatar","full_name":"Kamatar, Advika"},{"full_name":"Bravo, Jack Peter Kelly","first_name":"Jack Peter Kelly","last_name":"Bravo","orcid":"0000-0003-0456-0753","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e"},{"first_name":"Feng","last_name":"Yuan","full_name":"Yuan, Feng"},{"last_name":"Wang","first_name":"Liping","full_name":"Wang, Liping"},{"full_name":"Lafer, Eileen M.","first_name":"Eileen M.","last_name":"Lafer"},{"first_name":"David W.","last_name":"Taylor","full_name":"Taylor, David W."},{"last_name":"Stachowiak","first_name":"Jeanne C.","full_name":"Stachowiak, Jeanne C."},{"first_name":"Sapun H.","last_name":"Parekh","full_name":"Parekh, Sapun H."}],"page":"1494-1507","title":"Lipid droplets as substrates for protein phase separation","doi":"10.1016/j.bpj.2024.03.015","publisher":"Elsevier","publication_identifier":{"issn":["0006-3495"]},"abstract":[{"text":"Membrane-associated protein phase separation plays critical roles in cell biology, driving essential cellular phenomena from immune signaling to membrane traffic. Importantly, by reducing dimensionality from three to two dimensions, lipid bilayers can nucleate phase separation at far lower concentrations compared with those required for phase separation in solution. How might other intracellular lipid substrates, such as lipid droplets, contribute to nucleation of phase separation? Distinct from bilayer membranes, lipid droplets consist of a phospholipid monolayer surrounding a core of neutral lipids, and they are energy storage organelles that protect cells from lipotoxicity and oxidative stress. Here, we show that intrinsically disordered proteins can undergo phase separation on the surface of synthetic and cell-derived lipid droplets. Specifically, we find that the model disordered domains FUS LC and LAF-1 RGG separate into protein-rich and protein-depleted phases on the surfaces of lipid droplets. Owing to the hydrophobic nature of interactions between FUS LC proteins, increasing ionic strength drives an increase in its phase separation on droplet surfaces. The opposite is true for LAF-1 RGG, owing to the electrostatic nature of its interprotein interactions. In both cases, protein-rich phases on the surfaces of synthetic and cell-derived lipid droplets demonstrate molecular mobility indicative of a liquid-like state. Our results show that lipid droplets can nucleate protein condensates, suggesting that protein phase separation could be key in organizing biological processes involving lipid droplets.","lang":"eng"}],"scopus_import":"1","day":"04","volume":123,"month":"06","article_processing_charge":"No","publication":"Biophysical Journal","external_id":{"pmid":["38462838"]},"article_type":"original","type":"journal_article","fulldoi":"https://doi.org/10.1016/j.bpj.2024.03.015","year":"2024","issue":"11","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"article_type":"original","type":"journal_article","year":"2024","fulldoi":"https://doi.org/10.1126/science.adk0378","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"6682","acknowledgement":"We thank R. Fregoso Ocampo for assistance with negative-stain EM imaging. This work was funded by Dutch Research Council (NWO) VIDI grant VI.Vidi.203.074 (R.H.J.S.), NWO Spinoza grant SPI 93-537 (J.v.d.O.), European Research Council (ERC) Advanced grant ERC-AdG-834279 (J.v.d.O.), ERC CoG grant 817834 (T.J.G.E.), NWO VICI grant VI.C.192.016 (T.J.G.E.), Volkswagen Foundation grant 96725 (T.J.G.E.), National Institute of General Medical Sciences of the National Institutes of Health grant R35GM138348 (D.W.T.), Welch Foundation research grant F-1938 (D.W.T.), a Robert J. Kleberg, Jr. And Helen C. Kleberg Foundation medical research grant (D.W.T.), and American Cancer Society Research Scholar grant RSG-21-050-01-DMC (D.W.T.).","publisher":"American Association for the Advancement of Science","abstract":[{"text":"The generation of cyclic oligoadenylates and subsequent allosteric activation of proteins that carry sensory domains is a distinctive feature of type III CRISPR-Cas systems. In this work, we characterize a set of associated genes of a type III-B system from Haliangium ochraceum that contains two caspase-like proteases, SAVED-CHAT and PCaspase (prokaryotic caspase), co-opted from a cyclic oligonucleotide–based antiphage signaling system (CBASS). Cyclic tri–adenosine monophosphate (AMP)–induced oligomerization of SAVED-CHAT activates proteolytic activity of the CHAT domains, which specifically cleave and activate PCaspase. Subsequently, activated PCaspase cleaves a multitude of proteins, which results in a strong interference phenotype in vivo in Escherichia coli. Taken together, our findings reveal how a CRISPR-Cas–based detection of a target RNA triggers a cascade of caspase-associated proteolytic activities.","lang":"eng"}],"scopus_import":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"volume":383,"day":"01","month":"02","article_processing_charge":"No","oa":1,"publication":"Science","external_id":{"pmid":["38301007"]},"OA_place":"repository","page":"512-519","pmid":1,"date_published":"2024-02-01T00:00:00Z","author":[{"full_name":"Steens, Jurre A.","first_name":"Jurre A.","last_name":"Steens"},{"full_name":"Bravo, Jack Peter Kelly","first_name":"Jack Peter Kelly","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","orcid":"0000-0003-0456-0753","last_name":"Bravo"},{"first_name":"Carl Raymund P.","last_name":"Salazar","full_name":"Salazar, Carl Raymund P."},{"first_name":"Caglar","last_name":"Yildiz","full_name":"Yildiz, Caglar"},{"last_name":"Amieiro","first_name":"Afonso M.","full_name":"Amieiro, Afonso M."},{"full_name":"Köstlbacher, Stephan","first_name":"Stephan","last_name":"Köstlbacher"},{"last_name":"Prinsen","first_name":"Stijn H.P.","full_name":"Prinsen, Stijn H.P."},{"full_name":"Patinios, Constantinos","last_name":"Patinios","first_name":"Constantinos"},{"last_name":"Bardis","first_name":"Andreas","full_name":"Bardis, Andreas"},{"full_name":"Barendregt, Arjan","first_name":"Arjan","last_name":"Barendregt"},{"full_name":"Scheltema, Richard A.","last_name":"Scheltema","first_name":"Richard A."},{"last_name":"Ettema","first_name":"Thijs J.G.","full_name":"Ettema, Thijs J.G."},{"full_name":"van der Oost, John","last_name":"van der Oost","first_name":"John"},{"full_name":"Taylor, David W.","last_name":"Taylor","first_name":"David W."},{"full_name":"Staals, Raymond H.J.","last_name":"Staals","first_name":"Raymond H.J."}],"publication_status":"published","doi":"10.1126/science.adk0378","title":"Type III-B CRISPR-Cas cascade of proteolytic cleavages","OA_type":"green","date_created":"2024-06-04T06:41:26Z","intvolume":"       383","_id":"17112","date_updated":"2025-09-24T08:31:45Z","quality_controlled":"1","oa_version":"Preprint","language":[{"iso":"eng"}],"extern":"1","citation":{"ista":"Steens JA, Bravo JPK, Salazar CRP, Yildiz C, Amieiro AM, Köstlbacher S, Prinsen SHP, Patinios C, Bardis A, Barendregt A, Scheltema RA, Ettema TJG, van der Oost J, Taylor DW, Staals RHJ. 2024. Type III-B CRISPR-Cas cascade of proteolytic cleavages. Science. 383(6682), 512–519.","ama":"Steens JA, Bravo JPK, Salazar CRP, et al. Type III-B CRISPR-Cas cascade of proteolytic cleavages. <i>Science</i>. 2024;383(6682):512-519. doi:<a href=\"https://doi.org/10.1126/science.adk0378\">10.1126/science.adk0378</a>","mla":"Steens, Jurre A., et al. “Type III-B CRISPR-Cas Cascade of Proteolytic Cleavages.” <i>Science</i>, vol. 383, no. 6682, American Association for the Advancement of Science, 2024, pp. 512–19, doi:<a href=\"https://doi.org/10.1126/science.adk0378\">10.1126/science.adk0378</a>.","ieee":"J. A. Steens <i>et al.</i>, “Type III-B CRISPR-Cas cascade of proteolytic cleavages,” <i>Science</i>, vol. 383, no. 6682. American Association for the Advancement of Science, pp. 512–519, 2024.","chicago":"Steens, Jurre A., Jack Peter Kelly Bravo, Carl Raymund P. Salazar, Caglar Yildiz, Afonso M. Amieiro, Stephan Köstlbacher, Stijn H.P. Prinsen, et al. “Type III-B CRISPR-Cas Cascade of Proteolytic Cleavages.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.adk0378\">https://doi.org/10.1126/science.adk0378</a>.","apa":"Steens, J. A., Bravo, J. P. K., Salazar, C. R. P., Yildiz, C., Amieiro, A. M., Köstlbacher, S., … Staals, R. H. J. (2024). Type III-B CRISPR-Cas cascade of proteolytic cleavages. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adk0378\">https://doi.org/10.1126/science.adk0378</a>","short":"J.A. Steens, J.P.K. Bravo, C.R.P. Salazar, C. Yildiz, A.M. Amieiro, S. Köstlbacher, S.H.P. Prinsen, C. Patinios, A. Bardis, A. Barendregt, R.A. Scheltema, T.J.G. Ettema, J. van der Oost, D.W. Taylor, R.H.J. Staals, Science 383 (2024) 512–519."},"main_file_link":[{"url":"https://doi.org/10.1101/2023.06.23.546230","open_access":"1"}],"status":"public"},{"oa_version":"Published Version","extern":"1","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1038/s41467-024-47830-3","open_access":"1"}],"citation":{"ieee":"G. N. Hibshman <i>et al.</i>, “Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9,” <i>Nature Communications</i>, vol. 15. Springer Nature, 2024.","ista":"Hibshman GN, Bravo JPK, Hooper MM, Dangerfield TL, Zhang H, Finkelstein IJ, Johnson KA, Taylor DW. 2024. Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nature Communications. 15, 3663.","ama":"Hibshman GN, Bravo JPK, Hooper MM, et al. Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. <i>Nature Communications</i>. 2024;15. doi:<a href=\"https://doi.org/10.1038/s41467-024-47830-3\">10.1038/s41467-024-47830-3</a>","mla":"Hibshman, Grace N., et al. “Unraveling the Mechanisms of PAMless DNA Interrogation by SpRY-Cas9.” <i>Nature Communications</i>, vol. 15, 3663, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1038/s41467-024-47830-3\">10.1038/s41467-024-47830-3</a>.","short":"G.N. Hibshman, J.P.K. Bravo, M.M. Hooper, T.L. Dangerfield, H. Zhang, I.J. Finkelstein, K.A. Johnson, D.W. Taylor, Nature Communications 15 (2024).","apa":"Hibshman, G. N., Bravo, J. P. K., Hooper, M. M., Dangerfield, T. L., Zhang, H., Finkelstein, I. J., … Taylor, D. W. (2024). Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-024-47830-3\">https://doi.org/10.1038/s41467-024-47830-3</a>","chicago":"Hibshman, Grace N., Jack Peter Kelly Bravo, Matthew M. Hooper, Tyler L. Dangerfield, Hongshan Zhang, Ilya J. Finkelstein, Kenneth A. Johnson, and David W. Taylor. “Unraveling the Mechanisms of PAMless DNA Interrogation by SpRY-Cas9.” <i>Nature Communications</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41467-024-47830-3\">https://doi.org/10.1038/s41467-024-47830-3</a>."},"status":"public","intvolume":"        15","date_created":"2024-06-04T06:42:07Z","quality_controlled":"1","article_number":"3663","_id":"17113","date_updated":"2024-10-14T12:34:26Z","pmid":1,"publication_status":"published","date_published":"2024-04-30T00:00:00Z","author":[{"first_name":"Grace N.","last_name":"Hibshman","full_name":"Hibshman, Grace N."},{"full_name":"Bravo, Jack Peter Kelly","first_name":"Jack Peter Kelly","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","last_name":"Bravo","orcid":"0000-0003-0456-0753"},{"full_name":"Hooper, Matthew M.","last_name":"Hooper","first_name":"Matthew M."},{"last_name":"Dangerfield","first_name":"Tyler L.","full_name":"Dangerfield, Tyler L."},{"first_name":"Hongshan","last_name":"Zhang","full_name":"Zhang, Hongshan"},{"last_name":"Finkelstein","first_name":"Ilya J.","full_name":"Finkelstein, Ilya J."},{"full_name":"Johnson, Kenneth A.","last_name":"Johnson","first_name":"Kenneth A."},{"last_name":"Taylor","first_name":"David W.","full_name":"Taylor, David W."}],"title":"Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9","doi":"10.1038/s41467-024-47830-3","month":"04","oa":1,"article_processing_charge":"Yes","publication":"Nature Communications","external_id":{"pmid":["38688943"]},"publisher":"Springer Nature","publication_identifier":{"issn":["2041-1723"]},"scopus_import":"1","abstract":[{"lang":"eng","text":"CRISPR-Cas9 is a powerful tool for genome editing, but the strict requirement for an NGG protospacer-adjacent motif (PAM) sequence immediately next to the DNA target limits the number of editable genes. Recently developed Cas9 variants have been engineered with relaxed PAM requirements, including SpG-Cas9 (SpG) and the nearly PAM-less SpRY-Cas9 (SpRY). However, the molecular mechanisms of how SpRY recognizes all potential PAM sequences remains unclear. Here, we combine structural and biochemical approaches to determine how SpRY interrogates DNA and recognizes target sites. Divergent PAM sequences can be accommodated through conformational flexibility within the PAM-interacting region, which facilitates tight binding to off-target DNA sequences. Nuclease activation occurs ~1000-fold slower than for <jats:italic>Streptococcus pyogenes</jats:italic> Cas9, enabling us to directly visualize multiple on-pathway intermediate states. Experiments with SpG position it as an intermediate enzyme between Cas9 and SpRY. Our findings shed light on the molecular mechanisms of PAMless genome editing."}],"day":"30","volume":15,"fulldoi":"https://doi.org/10.1038/s41467-024-47830-3","year":"2024","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","type":"journal_article"},{"article_type":"original","type":"journal_article","year":"2024","fulldoi":"https://doi.org/10.1038/s41467-024-47506-y","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","abstract":[{"text":"CRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR RNA-guided surveillance complexes to target complementary RNA or DNA for destruction<jats:sup>1–5</jats:sup>. Target RNA cleavage at regular intervals is characteristic of type III effector complexes<jats:sup>6–8</jats:sup>. Here, we determine the structures of the <jats:italic>Synechocystis</jats:italic> type III-Dv complex, an apparent evolutionary intermediate from multi-protein to single-protein type III effectors<jats:sup>9,10</jats:sup>, in pre- and post-cleavage states. The structures show how multi-subunit fusion proteins in the effector are tethered together in an unusual arrangement to assemble into an active and programmable RNA endonuclease and how the effector utilizes a distinct mechanism for target RNA seeding from other type III effectors. Using structural, biochemical, and quantum/classical molecular dynamics simulation, we study the structure and dynamics of the three catalytic sites, where a 2′-OH of the ribose on the target RNA acts as a nucleophile for in line self-cleavage of the upstream scissile phosphate. Strikingly, the arrangement at the catalytic residues of most type III complexes resembles the active site of ribozymes, including the hammerhead, pistol, and Varkud satellite ribozymes. Our work provides detailed molecular insight into the mechanisms of RNA targeting and cleavage by an important intermediate in the evolution of type III effector complexes.","lang":"eng"}],"scopus_import":"1","publication_identifier":{"issn":["2041-1723"]},"volume":15,"day":"18","month":"04","article_processing_charge":"Yes","oa":1,"external_id":{"pmid":["38637512"]},"publication":"Nature Communications","date_published":"2024-04-18T00:00:00Z","pmid":1,"publication_status":"published","author":[{"full_name":"Schwartz, Evan A.","last_name":"Schwartz","first_name":"Evan A."},{"last_name":"Bravo","orcid":"0000-0003-0456-0753","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","first_name":"Jack Peter Kelly","full_name":"Bravo, Jack Peter Kelly"},{"full_name":"Ahsan, Mohd","first_name":"Mohd","last_name":"Ahsan"},{"first_name":"Luis A.","last_name":"Macias","full_name":"Macias, Luis A."},{"full_name":"McCafferty, Caitlyn L.","last_name":"McCafferty","first_name":"Caitlyn L."},{"full_name":"Dangerfield, Tyler L.","first_name":"Tyler L.","last_name":"Dangerfield"},{"full_name":"Walker, Jada N.","last_name":"Walker","first_name":"Jada N."},{"last_name":"Brodbelt","first_name":"Jennifer S.","full_name":"Brodbelt, Jennifer S."},{"last_name":"Palermo","first_name":"Giulia","full_name":"Palermo, Giulia"},{"last_name":"Fineran","first_name":"Peter C.","full_name":"Fineran, Peter C."},{"full_name":"Fagerlund, Robert D.","first_name":"Robert D.","last_name":"Fagerlund"},{"last_name":"Taylor","first_name":"David W.","full_name":"Taylor, David W."}],"doi":"10.1038/s41467-024-47506-y","title":"RNA targeting and cleavage by the type III-Dv CRISPR effector complex","date_created":"2024-06-04T06:43:02Z","intvolume":"        15","_id":"17114","date_updated":"2024-06-04T07:05:26Z","article_number":"3324","quality_controlled":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"extern":"1","citation":{"ieee":"E. A. Schwartz <i>et al.</i>, “RNA targeting and cleavage by the type III-Dv CRISPR effector complex,” <i>Nature Communications</i>, vol. 15. Springer Nature, 2024.","mla":"Schwartz, Evan A., et al. “RNA Targeting and Cleavage by the Type III-Dv CRISPR Effector Complex.” <i>Nature Communications</i>, vol. 15, 3324, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1038/s41467-024-47506-y\">10.1038/s41467-024-47506-y</a>.","ama":"Schwartz EA, Bravo JPK, Ahsan M, et al. RNA targeting and cleavage by the type III-Dv CRISPR effector complex. <i>Nature Communications</i>. 2024;15. doi:<a href=\"https://doi.org/10.1038/s41467-024-47506-y\">10.1038/s41467-024-47506-y</a>","ista":"Schwartz EA, Bravo JPK, Ahsan M, Macias LA, McCafferty CL, Dangerfield TL, Walker JN, Brodbelt JS, Palermo G, Fineran PC, Fagerlund RD, Taylor DW. 2024. RNA targeting and cleavage by the type III-Dv CRISPR effector complex. Nature Communications. 15, 3324.","short":"E.A. Schwartz, J.P.K. Bravo, M. Ahsan, L.A. Macias, C.L. McCafferty, T.L. Dangerfield, J.N. Walker, J.S. Brodbelt, G. Palermo, P.C. Fineran, R.D. Fagerlund, D.W. Taylor, Nature Communications 15 (2024).","apa":"Schwartz, E. A., Bravo, J. P. K., Ahsan, M., Macias, L. A., McCafferty, C. L., Dangerfield, T. L., … Taylor, D. W. (2024). RNA targeting and cleavage by the type III-Dv CRISPR effector complex. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-024-47506-y\">https://doi.org/10.1038/s41467-024-47506-y</a>","chicago":"Schwartz, Evan A., Jack Peter Kelly Bravo, Mohd Ahsan, Luis A. Macias, Caitlyn L. McCafferty, Tyler L. Dangerfield, Jada N. Walker, et al. “RNA Targeting and Cleavage by the Type III-Dv CRISPR Effector Complex.” <i>Nature Communications</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41467-024-47506-y\">https://doi.org/10.1038/s41467-024-47506-y</a>."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-024-47506-y"}],"status":"public"}]