[{"article_number":"102472","department":[{"_id":"GaTk"},{"_id":"NiBa"}],"date_created":"2026-04-26T22:01:46Z","corr_author":"1","date_updated":"2026-04-28T12:41:00Z","OA_place":"publisher","publication_identifier":{"issn":["0959-437X"],"eissn":["1879-0380"]},"intvolume":"        98","quality_controlled":"1","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1016/j.gde.2026.102472","open_access":"1"}],"publication":"Current Opinion in Genetics and Development","type":"journal_article","doi":"10.1016/j.gde.2026.102472","day":"15","publisher":"Elsevier","volume":98,"citation":{"short":"E. Mascolo, R.E. Körei, N.O. Borst, N.H. Barton, J. Crocker, G. Tkačik, Current Opinion in Genetics and Development 98 (2026).","ieee":"E. Mascolo, R. E. Körei, N. O. Borst, N. H. Barton, J. Crocker, and G. Tkačik, “Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges,” <i>Current Opinion in Genetics and Development</i>, vol. 98. Elsevier, 2026.","apa":"Mascolo, E., Körei, R. E., Borst, N. O., Barton, N. H., Crocker, J., &#38; Tkačik, G. (2026). Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges. <i>Current Opinion in Genetics and Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.gde.2026.102472\">https://doi.org/10.1016/j.gde.2026.102472</a>","mla":"Mascolo, Elia, et al. “Long-Term Evolution of Regulatory DNA Sequences. Part 2: Theory and Future Challenges.” <i>Current Opinion in Genetics and Development</i>, vol. 98, 102472, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.gde.2026.102472\">10.1016/j.gde.2026.102472</a>.","ista":"Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. 2026. Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges. Current Opinion in Genetics and Development. 98, 102472.","ama":"Mascolo E, Körei RE, Borst NO, Barton NH, Crocker J, Tkačik G. Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges. <i>Current Opinion in Genetics and Development</i>. 2026;98. doi:<a href=\"https://doi.org/10.1016/j.gde.2026.102472\">10.1016/j.gde.2026.102472</a>","chicago":"Mascolo, Elia, Reka E Körei, Noa O. Borst, Nicholas H Barton, Justin Crocker, and Gašper Tkačik. “Long-Term Evolution of Regulatory DNA Sequences. Part 2: Theory and Future Challenges.” <i>Current Opinion in Genetics and Development</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.gde.2026.102472\">https://doi.org/10.1016/j.gde.2026.102472</a>."},"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Elia","full_name":"Mascolo, Elia","id":"776a6ed0-a053-11f0-8635-80b95e0e0d53","last_name":"Mascolo","orcid":"0000-0003-2977-7844"},{"first_name":"Reka E","full_name":"Körei, Reka E","id":"50FDE43E-AA30-11E9-A72B-8A12E6697425","last_name":"Körei"},{"last_name":"Borst","full_name":"Borst, Noa O.","first_name":"Noa O."},{"last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"},{"last_name":"Crocker","first_name":"Justin","full_name":"Crocker, Justin"},{"first_name":"Gašper","full_name":"Tkačik, Gašper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","last_name":"Tkačik","orcid":"0000-0002-6699-1455"}],"project":[{"_id":"bd6958e0-d553-11ed-ba76-86eba6a76c00","grant_number":"101055327","name":"Understanding the evolution of continuous genomes"}],"article_type":"review","publication_status":"epub_ahead","acknowledgement":"We thank Calin Guet and Santiago Herrera-Álvarez for essential contributions to this manuscript.\r\nE.M. acknowledges support from the APART-USA fellowship, jointly funded by the Austrian Academy of Sciences (ÖAW) and the Institute of Science and Technology Austria (ISTA). N.B. acknowledges funding from the ERC Advanced Grant 101055327 “HaplotypeStructure”.\r\nThis study was also supported by the European Molecular Biology Laboratory (N.O.B., J.C.).","OA_type":"hybrid","status":"public","scopus_import":"1","abstract":[{"text":"Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target genes. Decades-long efforts yielded TF-DNA interaction models that predict how strongly an individual TF binds arbitrary DNA sequences and how individual binding events on the CRE combine to affect gene expression. These insights can be synthesized into a global, biophysically realistic, and quantitative genotype-phenotype (GP) map for gene regulation, a ‘holy grail’ for the application of evolutionary theory. A global map provides a rare opportunity to simulate the long-term evolution of regulatory sequences and pose several fundamental questions: How long does it take to evolve CREs de novo? How many non-trivial regulatory functions exist in sequence space? How connected are they? For which regulatory architecture is CRE evolution most rapid and evolvable? In this article, the second of a two-part series, we review the application of evolutionary concepts — epistasis, robustness, evolvability, tunability, plasticity, and bet-hedging — to the evolution of gene regulatory sequences. We then evaluate the potential for a unifying theory for the evolution of regulatory sequences and identify key open challenges.","lang":"eng"}],"date_published":"2026-04-15T00:00:00Z","month":"04","article_processing_charge":"Yes (via OA deal)","title":"Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges","oa_version":"Published Version","year":"2026","_id":"21759"},{"title":"Extending bilipschitz mappings between separated nets","keyword":["Lipschitz","bilipschitz","extension","separated net."],"year":"2026","_id":"21766","issue":"1","oa_version":"Published Version","month":"04","article_processing_charge":"Yes (in subscription journal)","OA_type":"hybrid","acknowledgement":"The present work developed from a research visit of M.D. to V.K. at IST Austria, funded by\r\na London Mathematical Society Research in Pairs grant. This work was done while V.K. was fully funded by the Austria Science Fund (FWF) [M 3100-N].","ddc":["510"],"arxiv":1,"date_published":"2026-04-17T00:00:00Z","scopus_import":"1","abstract":[{"text":"We provide a new characterisation of the decades old open problem of extending bilipschitz mappings given on a Euclidean separated net. In particular, this allows for the complete positive solution of the open problem in dimension two. Along the way, we develop a set of tools for bilipschitz extensions of mappings between subsets of Euclidean spaces.","lang":"eng"}],"status":"public","file":[{"date_updated":"2026-04-28T12:03:13Z","file_name":"2026_AnnalesFenniciMath_Dymond.pdf","checksum":"442023926a3803d5d6ca8db8dbc4af1c","success":1,"relation":"main_file","file_size":342082,"file_id":"21772","access_level":"open_access","creator":"dernst","date_created":"2026-04-28T12:03:13Z","content_type":"application/pdf"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"project":[{"grant_number":"M03100","_id":"fc35eaa2-9c52-11eb-aca3-88501ab155e9","name":"Spectra and topology of graphs and of simplicial complexes"}],"publication_status":"published","article_type":"original","author":[{"first_name":"Michael","full_name":"Dymond, Michael","last_name":"Dymond"},{"first_name":"Vojtech","id":"21AE5134-9EAC-11EA-BEA2-D7BD3DDC885E","full_name":"Kaluza, Vojtech","last_name":"Kaluza","orcid":"0000-0002-2512-8698"}],"page":"237-260","publisher":"Finnish Mathematical Society","day":"17","doi":"10.54330/afm.181562","type":"journal_article","citation":{"apa":"Dymond, M., &#38; Kaluza, V. (2026). Extending bilipschitz mappings between separated nets. <i>Annales Fennici Mathematici</i>. Finnish Mathematical Society. <a href=\"https://doi.org/10.54330/afm.181562\">https://doi.org/10.54330/afm.181562</a>","ista":"Dymond M, Kaluza V. 2026. Extending bilipschitz mappings between separated nets. Annales Fennici Mathematici. 51(1), 237–260.","mla":"Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between Separated Nets.” <i>Annales Fennici Mathematici</i>, vol. 51, no. 1, Finnish Mathematical Society, 2026, pp. 237–60, doi:<a href=\"https://doi.org/10.54330/afm.181562\">10.54330/afm.181562</a>.","ieee":"M. Dymond and V. Kaluza, “Extending bilipschitz mappings between separated nets,” <i>Annales Fennici Mathematici</i>, vol. 51, no. 1. Finnish Mathematical Society, pp. 237–260, 2026.","short":"M. Dymond, V. Kaluza, Annales Fennici Mathematici 51 (2026) 237–260.","chicago":"Dymond, Michael, and Vojtech Kaluza. “Extending Bilipschitz Mappings between Separated Nets.” <i>Annales Fennici Mathematici</i>. Finnish Mathematical Society, 2026. <a href=\"https://doi.org/10.54330/afm.181562\">https://doi.org/10.54330/afm.181562</a>.","ama":"Dymond M, Kaluza V. Extending bilipschitz mappings between separated nets. <i>Annales Fennici Mathematici</i>. 2026;51(1):237-260. doi:<a href=\"https://doi.org/10.54330/afm.181562\">10.54330/afm.181562</a>"},"volume":51,"publication":"Annales Fennici Mathematici","date_updated":"2026-04-28T12:06:00Z","has_accepted_license":"1","OA_place":"publisher","external_id":{"arxiv":["2507.22007"]},"corr_author":"1","intvolume":"        51","quality_controlled":"1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["2737-0690"],"eissn":["2737-114X"]},"tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"date_created":"2026-04-26T22:01:47Z","file_date_updated":"2026-04-28T12:03:13Z","department":[{"_id":"UlWa"}]},{"PlanS_conform":"1","department":[{"_id":"CaGo"},{"_id":"GradSch"}],"date_created":"2026-01-20T10:02:19Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"quality_controlled":"1","language":[{"iso":"eng"}],"corr_author":"1","has_accepted_license":"1","OA_place":"publisher","date_updated":"2026-04-28T11:56:45Z","publication":"Nature Physics","main_file_link":[{"url":"https://doi.org/10.1038/s41567-025-03120-3","open_access":"1"}],"citation":{"short":"M. Hübl, T.E. Videbæk, D. Hayakawa, W.B. Rogers, C.P. Goodrich, Nature Physics (2026).","ieee":"M. Hübl, T. E. Videbæk, D. Hayakawa, W. B. Rogers, and C. P. Goodrich, “A polyhedral structure controls programmable self-assembly,” <i>Nature Physics</i>. Springer Nature, 2026.","apa":"Hübl, M., Videbæk, T. E., Hayakawa, D., Rogers, W. B., &#38; Goodrich, C. P. (2026). A polyhedral structure controls programmable self-assembly. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-025-03120-3\">https://doi.org/10.1038/s41567-025-03120-3</a>","mla":"Hübl, Maximilian, et al. “A Polyhedral Structure Controls Programmable Self-Assembly.” <i>Nature Physics</i>, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41567-025-03120-3\">10.1038/s41567-025-03120-3</a>.","ista":"Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. 2026. A polyhedral structure controls programmable self-assembly. Nature Physics.","ama":"Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. A polyhedral structure controls programmable self-assembly. <i>Nature Physics</i>. 2026. doi:<a href=\"https://doi.org/10.1038/s41567-025-03120-3\">10.1038/s41567-025-03120-3</a>","chicago":"Hübl, Maximilian, Thomas E. Videbæk, Daichi Hayakawa, W. Benjamin Rogers, and Carl Peter Goodrich. “A Polyhedral Structure Controls Programmable Self-Assembly.” <i>Nature Physics</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41567-025-03120-3\">https://doi.org/10.1038/s41567-025-03120-3</a>."},"type":"journal_article","related_material":{"link":[{"url":"https://ista.ac.at/en/news/behind-natures-blueprints/","relation":"press_release","description":"News on ISTA website"}]},"doi":"10.1038/s41567-025-03120-3","day":"08","publisher":"Springer Nature","author":[{"last_name":"Hübl","first_name":"Maximilian","full_name":"Hübl, Maximilian","id":"5eb8629e-15b2-11ec-abd3-e6f3e5e01f32"},{"last_name":"Videbæk","full_name":"Videbæk, Thomas E.","first_name":"Thomas E."},{"last_name":"Hayakawa","full_name":"Hayakawa, Daichi","first_name":"Daichi"},{"full_name":"Rogers, W. Benjamin","first_name":"W. Benjamin","last_name":"Rogers"},{"last_name":"Goodrich","orcid":"0000-0002-1307-5074","first_name":"Carl Peter","full_name":"Goodrich, Carl Peter","id":"EB352CD2-F68A-11E9-89C5-A432E6697425"}],"publication_status":"epub_ahead","article_type":"original","project":[{"grant_number":"FTI23-G-011","_id":"8dd93da8-16d5-11f0-9cad-d2c70200d9a5","name":"Dynamically reconfigurable self-assembly with triangular DNA-origami bricks"}],"oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","status":"public","scopus_import":"1","date_published":"2026-01-08T00:00:00Z","abstract":[{"lang":"eng","text":"Modern experimental methods in programmable self-assembly make it possible to precisely design particle concentrations, shapes and interactions. However, more physical insight is needed before we can take full advantage of this vast design space to assemble nanostructures with complex form and function. Here we show how a substantial part of this design space can be quickly and comprehensively understood by identifying a class of thermodynamic constraints that act on it. These thermodynamic constraints form a high-dimensional convex polyhedron that determines which nanostructures can be assembled at high equilibrium yield and reveals limitations that govern the coexistence of structures. We validate our predictions through detailed, quantitative assembly experiments of nanoscale particles synthesized using DNA origami. Our results uncover physical relationships underpinning many-component programmable self-assembly in equilibrium and form the basis for robust inverse design, applicable to various systems from biological protein complexes to synthetic nanomachines."}],"ddc":["570","540"],"acknowledgement":"We thank B. Isaac and A. Tiano for their technical support with the electron microscopy and S. Waitukaitis for helpful comments on the manuscript. The TEM images were prepared and imaged at the Brandeis Electron Microscopy facility. This work was supported by the Gesellschaft für Forschungsförderung Niederösterreich under project FTI23-G-011 (M.C.H. and C.P.G.), the Brandeis University Materials Research Science and Engineering Center (MRSEC) under grant number NSF DMR-2011846 (T.E.V., D.H. and W.B.R.) and the Smith Family Foundation (W.B.R.). Open access funding provided by Institute of Science and Technology (IST Austria).","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","month":"01","oa_version":"Published Version","_id":"21006","year":"2026","title":"A polyhedral structure controls programmable self-assembly"},{"external_id":{"arxiv":["2509.07678"]},"has_accepted_license":"1","OA_place":"publisher","date_updated":"2026-04-28T13:08:39Z","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"      1001","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"LiBu"}],"PlanS_conform":"1","article_number":"146","date_created":"2026-04-26T22:01:46Z","file_date_updated":"2026-04-28T13:06:00Z","type":"journal_article","ec_funded":1,"doi":"10.3847/1538-4357/ae56ff","publisher":"IOP Publishing","day":"20","volume":1001,"citation":{"short":"X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A.J. Mustill, M. Manteiga, The Astrophysical Journal 1001 (2026).","ieee":"X. Pérez-Couto, S. Torres Rodriguez, E. Villaver, A. J. Mustill, and M. Manteiga, “3I/ATLAS: In search of the witnesses to its voyage,” <i>The Astrophysical Journal</i>, vol. 1001, no. 2. IOP Publishing, 2026.","apa":"Pérez-Couto, X., Torres Rodriguez, S., Villaver, E., Mustill, A. J., &#38; Manteiga, M. (2026). 3I/ATLAS: In search of the witnesses to its voyage. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ae56ff\">https://doi.org/10.3847/1538-4357/ae56ff</a>","ista":"Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 2026. 3I/ATLAS: In search of the witnesses to its voyage. The Astrophysical Journal. 1001(2), 146.","mla":"Pérez-Couto, X., et al. “3I/ATLAS: In Search of the Witnesses to Its Voyage.” <i>The Astrophysical Journal</i>, vol. 1001, no. 2, 146, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/1538-4357/ae56ff\">10.3847/1538-4357/ae56ff</a>.","ama":"Pérez-Couto X, Torres Rodriguez S, Villaver E, Mustill AJ, Manteiga M. 3I/ATLAS: In search of the witnesses to its voyage. <i>The Astrophysical Journal</i>. 2026;1001(2). doi:<a href=\"https://doi.org/10.3847/1538-4357/ae56ff\">10.3847/1538-4357/ae56ff</a>","chicago":"Pérez-Couto, X., Santiago Torres Rodriguez, E. Villaver, A. J. Mustill, and M. Manteiga. “3I/ATLAS: In Search of the Witnesses to Its Voyage.” <i>The Astrophysical Journal</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/1538-4357/ae56ff\">https://doi.org/10.3847/1538-4357/ae56ff</a>."},"DOAJ_listed":"1","publication":"The Astrophysical Journal","ddc":["520"],"arxiv":1,"acknowledgement":"We thank the anonymous referee for a careful reading of the manuscript and for constructive comments that improved the paper. X.P.C. and S.T. thank J.L. Gragera-Más and Ylva Götberg for their valuable feedback and comments. X.P.C. acknowledges financial support from the Spanish National Programme for the Promotion of Talent and its Employability grant PRE2022-104959 cofunded by the European Social Fund. S.T. acknowledges the funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 101034413. E.V. acknowledges support from the DISCOBOLO project funded by the Spanish Ministerio de Ciencia, Innovación y Universidades under grant PID2021-127289NB-I00. A.J.M. acknowledges support from the Swedish National Space Agency (Career grant 2023-00146). X.P.C. and M.M. acknowledge support from the Spanish Ministerio de Ciencia, Innovaciòn y Universidades under grants PID2021122842OB-C22 and PID2024-157964OB-C22; from the Xunta de Galicia and the European Union (FEDER Galicia 2021-2027 Program) Ref. ED431B 2024/21, ED431B 2024/02, and CITIC ED431G 2023/01. This work has made use of data from the European Space Agency (ESA) Gaia mission and processed by the Gaia Data Processing and Analysis Consortium (DPAC). Funding for the DPAC has been provided by national institutions, particularly the institutions participating in the Gaia Multilateral Agreement.","OA_type":"gold","status":"public","date_published":"2026-04-20T00:00:00Z","abstract":[{"text":"3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua and 2I/Borisov. Its unusually high excess velocity and active cometary nature make it a key probe of the Galactic population of icy planetesimals. Understanding its origin requires its past trajectory through the Galaxy to be traced and the possible role of stellar encounters to be assessed, both as a potential origin and a perturber to its orbit. We integrated the orbit of 3I/ATLAS backward in time for 10 Myr, together with a sample of Gaia DR3 stars with high-quality astrometry and radial velocities, to identify close passages within 2 pc. We identify 93 nominal encounters, 62 of which are significant at the 2σ level. However, none of these encounters produced any meaningful perturbation. The strongest perturber Gaia DR3 6863591389529611264 at 0.30 pc and with a relative velocity of 35 km s−1, imparted only a velocity change of ∣Δv∣  ≃  5  ×  10−4 km s−1 to the orbit of 3I/ATLAS. Our results indicate that no stellar flybys within the past 10 Myr and 500 pc contained in Gaia DR3 can account for the present trajectory of 3I/ATLAS or be associated with its origin. We further show that 3I/ATLAS is kinematically consistent with a thin-disk population, despite its large peculiar velocity.","lang":"eng"}],"scopus_import":"1","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"content_type":"application/pdf","creator":"dernst","date_created":"2026-04-28T13:06:00Z","access_level":"open_access","file_id":"21773","relation":"main_file","file_size":2905627,"success":1,"checksum":"c3daf49261a9933c079854c38eec316f","file_name":"2026_AstrophysicalJournal_PerezCouto.pdf","date_updated":"2026-04-28T13:06:00Z"}],"author":[{"full_name":"Pérez-Couto, X.","first_name":"X.","last_name":"Pérez-Couto"},{"orcid":"0000-0002-3150-8988","last_name":"Torres Rodriguez","first_name":"Santiago","full_name":"Torres Rodriguez, Santiago","id":"a8df4360-4328-11ee-8f1a-e502d0c83fc2"},{"last_name":"Villaver","first_name":"E.","full_name":"Villaver, E."},{"first_name":"A. J.","full_name":"Mustill, A. J.","last_name":"Mustill"},{"last_name":"Manteiga","full_name":"Manteiga, M.","first_name":"M."}],"publication_status":"published","article_type":"original","project":[{"grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020"}],"title":"3I/ATLAS: In search of the witnesses to its voyage","oa_version":"Published Version","_id":"21760","issue":"2","year":"2026","month":"04","article_processing_charge":"Yes"},{"intvolume":"        36","quality_controlled":"1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0960-9822"],"eissn":["1879-0445"]},"date_updated":"2026-04-28T13:15:42Z","has_accepted_license":"1","OA_place":"publisher","external_id":{"pmid":["41881011"]},"date_created":"2026-04-26T22:01:46Z","file_date_updated":"2026-04-28T13:13:40Z","department":[{"_id":"AnSa"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"citation":{"short":"F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36 (2026) 1903–1917.e5.","mla":"Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” <i>Current Biology</i>, vol. 36, no. 8, Elsevier, 2026, p. 1903–1917.e5, doi:<a href=\"https://doi.org/10.1016/j.cub.2026.02.068\">10.1016/j.cub.2026.02.068</a>.","apa":"Perez Verdugo, F. L., Maniou, E., Galea, G. L., &#38; Banerjee, S. (2026). Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2026.02.068\">https://doi.org/10.1016/j.cub.2026.02.068</a>","ista":"Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 36(8), 1903–1917.e5.","ieee":"F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,” <i>Current Biology</i>, vol. 36, no. 8. Elsevier, p. 1903–1917.e5, 2026.","ama":"Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. <i>Current Biology</i>. 2026;36(8):1903-1917.e5. doi:<a href=\"https://doi.org/10.1016/j.cub.2026.02.068\">10.1016/j.cub.2026.02.068</a>","chicago":"Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” <i>Current Biology</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.cub.2026.02.068\">https://doi.org/10.1016/j.cub.2026.02.068</a>."},"volume":36,"page":"1903-1917.e5","doi":"10.1016/j.cub.2026.02.068","day":"20","publisher":"Elsevier","type":"journal_article","publication":"Current Biology","scopus_import":"1","date_published":"2026-04-20T00:00:00Z","abstract":[{"text":"Neural tube closure is a critical morphogenetic process in vertebrate development, and failure to close cranial regions such as the hindbrain neuropore (HNP) leads to severe congenital malformations. While mechanical forces such as actomyosin purse-string contraction and directional cell crawling have been implicated in driving HNP closure, how these forces organize local cell shape and motion to produce large-scale tissue remodeling remains poorly understood. Using live and fixed imaging of mouse embryos combined with cell-based biophysical modeling, we show that these force-generating mechanisms are insufficient to explain the reproducible patterns of cell elongation and nematic alignment observed at the HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization are required to generate these patterns and promote midline cell motion. Our model captures key features of cell shape dynamics and emergent nematic order, which we confirm experimentally, including the alignment of actin fibers with cell shape and enhanced midline cell speed. Comparative analysis with chick embryos, which lack supracellular purse strings, supports a conserved link between tension generation and cellular patterning. These findings establish a physical framework connecting force generation, cell shape anisotropy, and tissue morphodynamics during epithelial gap closure.","lang":"eng"}],"status":"public","OA_type":"hybrid","acknowledgement":"S.B. acknowledges support from the National Institutes of Health (NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G. acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society (RG\\R2\\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028. F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros).","ddc":["570"],"publication_status":"published","article_type":"original","author":[{"full_name":"Perez Verdugo, Fernanda L","id":"4ecec223-9070-11ef-a0a9-bc76077bea8d","first_name":"Fernanda L","last_name":"Perez Verdugo"},{"full_name":"Maniou, Eirini","first_name":"Eirini","last_name":"Maniou"},{"last_name":"Galea","full_name":"Galea, Gabriel L.","first_name":"Gabriel L."},{"full_name":"Banerjee, Shiladitya","first_name":"Shiladitya","last_name":"Banerjee"}],"file":[{"file_id":"21774","relation":"main_file","file_size":13402043,"content_type":"application/pdf","date_created":"2026-04-28T13:13:40Z","creator":"dernst","access_level":"open_access","file_name":"2026_CurrentBiology_PerezVerdugo.pdf","date_updated":"2026-04-28T13:13:40Z","success":1,"checksum":"80ae45457b4682c50c84f54de15aa9a8"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"year":"2026","issue":"8","_id":"21761","oa_version":"Published Version","title":"Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis","article_processing_charge":"Yes (in subscription journal)","pmid":1,"month":"04"},{"title":"Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape","_id":"21762","issue":"6795","year":"2026","oa_version":"None","pmid":1,"month":"04","article_processing_charge":"No","OA_type":"closed access","acknowledgement":"We thank all members of the Loose lab at ISTA for helpful discussions; M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University) for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work was funded by the European Union’s Horizon 2020 research and innovation program (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques et Letitia Lopez-Loreta Foundation (G.L.W.).","abstract":[{"lang":"eng","text":"Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal system named CorMR with a function in cell shape control rather than DNA segregation. Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed that CorM formed dynamically unstable, antiparallel double-stranded filaments that were recruited to the membrane by CorR through an amphipathic helix conserved in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which excluded them from the poles and division plane. Comparative genomics indicated that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity, highlighting the evolutionary plasticity of cytoskeletal systems in bacteria."}],"scopus_import":"1","date_published":"2026-04-16T00:00:00Z","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","publication_status":"published","project":[{"call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"},{"grant_number":"101076260","_id":"bd980d18-d553-11ed-ba76-ceaa645c97eb","name":"A molecular atlas of Actin filament IDentities in the cell motility machinery"}],"author":[{"first_name":"Benjamin L","full_name":"Springstein, Benjamin L","id":"b4eb62ef-ac72-11ed-9503-ed3b4d66c083","orcid":"0000-0002-3461-5391","last_name":"Springstein"},{"last_name":"Javoor","orcid":"0000-0003-2311-2112","full_name":"Javoor, Manjunath","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","first_name":"Manjunath"},{"full_name":"Megrian, Daniela","first_name":"Daniela","last_name":"Megrian"},{"last_name":"Hajdu","full_name":"Hajdu, Roman","id":"ffab949d-133f-11ed-8f02-94de21ace503","first_name":"Roman"},{"last_name":"Hanke","full_name":"Hanke, Dustin M.","first_name":"Dustin M."},{"full_name":"Zens, Bettina","id":"45FD126C-F248-11E8-B48F-1D18A9856A87","first_name":"Bettina","orcid":"0000-0002-9561-1239","last_name":"Zens"},{"full_name":"Weiss, Gregor L.","first_name":"Gregor L.","last_name":"Weiss"},{"first_name":"Florian Km","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","full_name":"Schur, Florian Km","last_name":"Schur","orcid":"0000-0003-4790-8078"},{"last_name":"Loose","orcid":"0000-0001-7309-9724","full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","first_name":"Martin"}],"publisher":"AAAS","doi":"10.1126/science.aea6343","day":"16","type":"journal_article","ec_funded":1,"citation":{"short":"B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L. Weiss, F.K. Schur, M. Loose, Science 392 (2026).","ieee":"B. L. Springstein <i>et al.</i>, “Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape,” <i>Science</i>, vol. 392, no. 6795. AAAS, 2026.","mla":"Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” <i>Science</i>, vol. 392, no. 6795, eaea6343, AAAS, 2026, doi:<a href=\"https://doi.org/10.1126/science.aea6343\">10.1126/science.aea6343</a>.","ista":"Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL, Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 392(6795), eaea6343.","apa":"Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens, B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aea6343\">https://doi.org/10.1126/science.aea6343</a>","ama":"Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. <i>Science</i>. 2026;392(6795). doi:<a href=\"https://doi.org/10.1126/science.aea6343\">10.1126/science.aea6343</a>","chicago":"Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu, Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” <i>Science</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/science.aea6343\">https://doi.org/10.1126/science.aea6343</a>."},"volume":392,"publication":"Science","date_updated":"2026-04-28T13:29:05Z","corr_author":"1","external_id":{"pmid":["41990175"]},"quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"       392","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"date_created":"2026-04-26T22:01:46Z","department":[{"_id":"MaLo"},{"_id":"FlSc"},{"_id":"GradSch"},{"_id":"EM-Fac"}],"article_number":"eaea6343"},{"publication":"Geophysical Research Letters","type":"journal_article","ec_funded":1,"doi":"10.1029/2025gl119921","day":"28","publisher":"Wiley","volume":53,"citation":{"chicago":"Biagioli, Giovanni, Giulio Mandorli, Lilli Johanna Freischem, Alejandro Casallas Garcia, and Adrian Mark Tompkins. “Spatial Patterns of Shallow Clouds: Challenging the Concept of Defined Regimes.” <i>Geophysical Research Letters</i>. Wiley, 2026. <a href=\"https://doi.org/10.1029/2025gl119921\">https://doi.org/10.1029/2025gl119921</a>.","ama":"Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. Spatial patterns of shallow clouds: Challenging the concept of defined regimes. <i>Geophysical Research Letters</i>. 2026;53(8). doi:<a href=\"https://doi.org/10.1029/2025gl119921\">10.1029/2025gl119921</a>","apa":"Biagioli, G., Mandorli, G., Freischem, L. J., Casallas Garcia, A., &#38; Tompkins, A. M. (2026). Spatial patterns of shallow clouds: Challenging the concept of defined regimes. <i>Geophysical Research Letters</i>. Wiley. <a href=\"https://doi.org/10.1029/2025gl119921\">https://doi.org/10.1029/2025gl119921</a>","ista":"Biagioli G, Mandorli G, Freischem LJ, Casallas Garcia A, Tompkins AM. 2026. Spatial patterns of shallow clouds: Challenging the concept of defined regimes. Geophysical Research Letters. 53(8), e2025GL119921.","mla":"Biagioli, Giovanni, et al. “Spatial Patterns of Shallow Clouds: Challenging the Concept of Defined Regimes.” <i>Geophysical Research Letters</i>, vol. 53, no. 8, e2025GL119921, Wiley, 2026, doi:<a href=\"https://doi.org/10.1029/2025gl119921\">10.1029/2025gl119921</a>.","ieee":"G. Biagioli, G. Mandorli, L. J. Freischem, A. Casallas Garcia, and A. M. Tompkins, “Spatial patterns of shallow clouds: Challenging the concept of defined regimes,” <i>Geophysical Research Letters</i>, vol. 53, no. 8. Wiley, 2026.","short":"G. Biagioli, G. Mandorli, L.J. Freischem, A. Casallas Garcia, A.M. Tompkins, Geophysical Research Letters 53 (2026)."},"DOAJ_listed":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"CaMu"}],"PlanS_conform":"1","article_number":"e2025GL119921","file_date_updated":"2026-04-21T06:07:22Z","date_created":"2026-04-21T06:04:41Z","has_accepted_license":"1","OA_place":"publisher","date_updated":"2026-04-28T13:35:53Z","publication_identifier":{"issn":["0094-8276"],"eissn":["1944-8007"]},"quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"        53","month":"04","article_processing_charge":"Yes","title":"Spatial patterns of shallow clouds: Challenging the concept of defined regimes","oa_version":"Published Version","_id":"21755","issue":"8","year":"2026","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"content_type":"application/pdf","access_level":"open_access","creator":"acasalla","date_created":"2026-04-21T06:07:22Z","file_id":"21756","relation":"main_file","file_size":1544417,"success":1,"checksum":"2cd4ae120b14b244f5b2f50eaae0efc1","date_updated":"2026-04-21T06:07:22Z","file_name":"Gio_Casallas_2026.pdf"}],"author":[{"last_name":"Biagioli","first_name":"Giovanni","full_name":"Biagioli, Giovanni"},{"full_name":"Mandorli, Giulio","first_name":"Giulio","last_name":"Mandorli"},{"last_name":"Freischem","full_name":"Freischem, Lilli Johanna","first_name":"Lilli Johanna"},{"last_name":"Casallas Garcia","orcid":"0000-0002-1988-5035","full_name":"Casallas Garcia, Alejandro","id":"92081129-2d75-11ef-a48d-b04dd7a2385a","first_name":"Alejandro"},{"full_name":"Tompkins, Adrian Mark","first_name":"Adrian Mark","last_name":"Tompkins"}],"article_type":"original","publication_status":"published","project":[{"name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413"}],"ddc":["550"],"acknowledgement":"GB was supported by an ICTP Postdoctoral Research Fellowship Agreement. GM was supported by the CNRS. AC was supported by the European Union's Horizon 2020 research and innovation programme Marie Sklodowska-Curie Grant agreement No 101034413. LJF acknowledges funding from the NERC Doctoral Training Partnership in Environmental Research Grant NE/S007474/1. We thank three anonymous reviewers and Jiawei Bao for their insightful comments, which greatly improved this manuscript.","OA_type":"gold","status":"public","scopus_import":"1","date_published":"2026-04-28T00:00:00Z","abstract":[{"lang":"eng","text":"Tropical shallow clouds are a major source of uncertainty in Earth's climate sensitivity, especially through their spatial arrangement, which global climate models do not represent. Efforts to understand their organization have partly relied on classifying observed scenes, identifying four patterns as archetypal regimes. Here we analyze geostationary satellite imagery of the western tropical Atlantic using the L‐function, a tool based on point pattern theory that quantifies cloud organization across spatial scales. Classical examples of the four patterns show distinct L‐function fingerprints, revealing their characteristic clustering and regularity scales and aiding physical interpretation. Yet, when evaluating many scenes at fixed spatial scales, the L‐function distribution lacks the distinct modes expected from discrete regimes. This is corroborated by analyses of other organization indices employing diverse approaches, from inter‐cloud nearest‐neighbor distances to fractal analysis. Implications for the parameterization of mesoscale cloud organization in climate models are discussed."}]},{"corr_author":"1","date_updated":"2026-04-28T14:11:13Z","has_accepted_license":"1","OA_place":"publisher","publication_identifier":{"eissn":["1096-3634"],"issn":["1084-9521"]},"quality_controlled":"1","language":[{"iso":"eng"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_number":"103670","PlanS_conform":"1","department":[{"_id":"XiFe"}],"file_date_updated":"2026-04-28T13:58:47Z","date_created":"2026-04-19T22:07:49Z","type":"journal_article","day":"01","doi":"10.1016/j.semcdb.2026.103670","publisher":"Elsevier","volume":"179-180","citation":{"short":"H. NAGAI, Y.I. Nakajima, Seminars in Cell and Developmental Biology 179–180 (2026).","apa":"NAGAI, H., &#38; Nakajima, Y. I. (2026). Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms. <i>Seminars in Cell and Developmental Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.semcdb.2026.103670\">https://doi.org/10.1016/j.semcdb.2026.103670</a>","ista":"NAGAI H, Nakajima YI. 2026. Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms. Seminars in Cell and Developmental Biology. 179–180, 103670.","mla":"NAGAI, HIROKI, and Yu Ichiro Nakajima. “Epithelial Cell Plasticity in Metazoans: Evolutionary Insights into Roles and Mechanisms.” <i>Seminars in Cell and Developmental Biology</i>, vol. 179–180, 103670, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.semcdb.2026.103670\">10.1016/j.semcdb.2026.103670</a>.","ieee":"H. NAGAI and Y. I. Nakajima, “Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms,” <i>Seminars in Cell and Developmental Biology</i>, vol. 179–180. Elsevier, 2026.","ama":"NAGAI H, Nakajima YI. Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms. <i>Seminars in Cell and Developmental Biology</i>. 2026;179-180. doi:<a href=\"https://doi.org/10.1016/j.semcdb.2026.103670\">10.1016/j.semcdb.2026.103670</a>","chicago":"NAGAI, HIROKI, and Yu Ichiro Nakajima. “Epithelial Cell Plasticity in Metazoans: Evolutionary Insights into Roles and Mechanisms.” <i>Seminars in Cell and Developmental Biology</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.semcdb.2026.103670\">https://doi.org/10.1016/j.semcdb.2026.103670</a>."},"publication":"Seminars in Cell and Developmental Biology","acknowledgement":"This work was supported by JSPS/MEXT KAKENHI (grant numbers JP22J01430 to H.N., JP23H04696, JP23K24025, JP25H02543, JP25K02406 to Y.N.), JST FOREST Program JPMJFR233E (Y.N.), The Cell Science Research Foundation (Y.N.), and Takeda Science Foundation (Y.N.).","ddc":["570"],"OA_type":"hybrid","status":"public","scopus_import":"1","abstract":[{"lang":"eng","text":"Epithelial tissues function as multicellular communities that preserve tissue integrity while adapting to diverse environmental stresses by altering cell behaviors. A striking manifestation of such adaptability is cell plasticity, the ability of differentiated cells to revert to stem-like states or adopt alternative fates. Once considered rare and confined to highly regenerative species, cell plasticity is now recognized across the metazoan tree. In early-branching animals such as sponges and cnidarians, transdifferentiation and dedifferentiation are integral to life-cycle transitions and regeneration, whereas in more complex organisms, these processes typically emerge under stress, including stem cell loss or environmental perturbations. Here, we examine epithelial cell plasticity through evolutionary, cellular, and molecular perspectives. Focusing on the intestinal epithelium, we explore findings from mammalian and Drosophila models showing that progenitors and even terminally differentiated cells can dedifferentiate in response to external stimuli that disrupt homeostasis, such as pathogen infection and nutrient fluctuations. We further discuss conserved mechanisms involving intercellular signaling (e.g., Notch, EGFR, and JAK-STAT) and chromatin states primed for reprogramming, modulated by metabolic cues. Together, these insights position cell plasticity as an ancient environmental adaptation strategy, shaped by conserved molecular toolkits and refined by species- and cell lineage-specific innovations."}],"date_published":"2026-05-01T00:00:00Z","oa":1,"file":[{"date_updated":"2026-04-28T13:58:47Z","file_name":"2026_SeminarsCellDevBiology_Nagai.pdf","checksum":"0a0929a045d0cbd964297768833c14ae","success":1,"file_size":1306613,"relation":"main_file","file_id":"21775","access_level":"open_access","date_created":"2026-04-28T13:58:47Z","creator":"dernst","content_type":"application/pdf"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Nagai","orcid":"0000-0003-1671-9434","first_name":"Hiroki","full_name":"Nagai, Hiroki","id":"608df3e6-e2ab-11ed-8890-c9318cec7da4"},{"first_name":"Yu Ichiro","full_name":"Nakajima, Yu Ichiro","last_name":"Nakajima"}],"article_type":"review","publication_status":"published","title":"Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms","oa_version":"Published Version","year":"2026","_id":"21752","month":"05","article_processing_charge":"Yes (in subscription journal)"},{"date_updated":"2026-05-04T06:37:12Z","has_accepted_license":"1","OA_place":"publisher","external_id":{"arxiv":["2601.07925"]},"intvolume":"      1000","quality_controlled":"1","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1538-4357"],"issn":["0004-637X"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2026-04-12T22:01:47Z","file_date_updated":"2026-05-04T06:36:00Z","article_number":"237","department":[{"_id":"IlCa"}],"publisher":"IOP Publishing","day":"01","doi":"10.3847/1538-4357/ae4871","type":"journal_article","citation":{"apa":"Chickles, E. T., Chakraborty, J., Burdge, K. B., Dhillon, V. S., Draghis, P., El-Badry, K., … Simcoe, R. (2026). An eclipsing 8.56 minutes orbital period mass-transferring binary. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ae4871\">https://doi.org/10.3847/1538-4357/ae4871</a>","mla":"Chickles, Emma T., et al. “An Eclipsing 8.56 Minutes Orbital Period Mass-Transferring Binary.” <i>The Astrophysical Journal</i>, vol. 1000, no. 2, 237, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/1538-4357/ae4871\">10.3847/1538-4357/ae4871</a>.","ista":"Chickles ET, Chakraborty J, Burdge KB, Dhillon VS, Draghis P, El-Badry K, Green MJ, Householder A, Hughes S, Layden C, Littlefair SP, Munday J, Pelisoli I, Redden MS, Tonry J, van Roestel JC, Angile FE, Brown AJ, Segura NC, Dinsmore J, Dyer M, Furesz G, Gabutti M, Garbutt J, García-Mejía J, Jarvis D, Kennedy MR, Kerry P, Mccormac J, Mo G, Osip D, Parsons S, Pike E, Piotrowski JJ, Romani RW, Sahman D, Simcoe R. 2026. An eclipsing 8.56 minutes orbital period mass-transferring binary. The Astrophysical Journal. 1000(2), 237.","ieee":"E. T. Chickles <i>et al.</i>, “An eclipsing 8.56 minutes orbital period mass-transferring binary,” <i>The Astrophysical Journal</i>, vol. 1000, no. 2. IOP Publishing, 2026.","short":"E.T. Chickles, J. Chakraborty, K.B. Burdge, V.S. Dhillon, P. Draghis, K. El-Badry, M.J. Green, A. Householder, S. Hughes, C. Layden, S.P. Littlefair, J. Munday, I. Pelisoli, M.S. Redden, J. Tonry, J.C. van Roestel, F.E. Angile, A.J. Brown, N.C. Segura, J. Dinsmore, M. Dyer, G. Furesz, M. Gabutti, J. Garbutt, J. García-Mejía, D. Jarvis, M.R. Kennedy, P. Kerry, J. Mccormac, G. Mo, D. Osip, S. Parsons, E. Pike, J.J. Piotrowski, R.W. Romani, D. Sahman, R. Simcoe, The Astrophysical Journal 1000 (2026).","chicago":"Chickles, Emma T., Joheen Chakraborty, Kevin B. Burdge, Vik S. Dhillon, Paul Draghis, Kareem El-Badry, Matthew J. Green, et al. “An Eclipsing 8.56 Minutes Orbital Period Mass-Transferring Binary.” <i>The Astrophysical Journal</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/1538-4357/ae4871\">https://doi.org/10.3847/1538-4357/ae4871</a>.","ama":"Chickles ET, Chakraborty J, Burdge KB, et al. An eclipsing 8.56 minutes orbital period mass-transferring binary. <i>The Astrophysical Journal</i>. 2026;1000(2). doi:<a href=\"https://doi.org/10.3847/1538-4357/ae4871\">10.3847/1538-4357/ae4871</a>"},"DOAJ_listed":"1","volume":1000,"publication":"The Astrophysical Journal","OA_type":"gold","acknowledgement":"This work has made use of data from the Asteroid Terrestrial-impact Last Alert System (ATLAS) project. The Asteroid Terrestrial-impact Last Alert System (ATLAS) project is primarily funded to search for near-Earth asteroids through NASA grants NN12AR55G, 80NSSC18K0284, and 80NSSC18K1575; byproducts of the NEO search include images and catalogs from the survey area. This work was partially funded by Kepler/K2 grant J1944/80NSSC19K0112 and HST GO-15889 and STFC grants ST/T000198/1 and ST/S006109/1. The ATLAS science products have been made possible through the contributions of the University of Hawaii Institute for Astronomy, the Queen’s University Belfast, the Space Telescope Science Institute, the South African Astronomical Observatory, and the Millennium Institute of Astrophysics (MAS), Chile. VSD and ULTRACAM are supported by STFC grant ST/Z000033/1. J.G.M. gratefully acknowledges support from the Heising-Simons Foundation and the Pappalardo family through the MIT Pappalardo Fellowship in Physics.","ddc":["520"],"arxiv":1,"date_published":"2026-04-01T00:00:00Z","abstract":[{"lang":"eng","text":"We report the discovery of ATLAS J101342.5−451656.8 (hereafter ATLAS J1013−4516), an 8.56 minute orbital-period mass-transferring AM Canum Venaticorum (AM CVn) binary with a mean Gaia magnitude of G = 19.51, identified via periodic variability in light curves from the Asteroid Terrestrial-impact Last Alert System (ATLAS) of Gaia white dwarf candidates. Follow-up with the Large Lenslet Array Magellan Spectrograph shows a helium-dominated accretion disk, and high-speed ULTRACAM photometry reveals pronounced primary and secondary eclipses. We construct a decade-long timing baseline leveraging light curves from the ATLAS and Gaia surveys, as well as the high-speed imagers ULTRACAM on the New Energy Telescope and proto-Lightspeed on the Magellan Clay telescope. From this timing baseline, we measure an orbital period derivative of P 1.60 0.07 10 = ± × 12 s s−1. Interpreted in the context of stable mass transfer, the magnitude and sign of P indicate that the orbital evolution is governed by the interplay between gravitationalwave-driven angular-momentum losses and mass transfer, directly probing the donor’s structural response to mass loss. We constrain the accretor and donor mass based on stable mass-transfer arguments assuming angularmomentum loss dominated by gravitational-wave emission, allowing us to infer the characteristic gravitational\r\nwave strain of the binary for future space-based GW observatories such as the Laser Interferometer Space Antenna (LISA). We predict a characteristic strain corresponding to a 4 yr LISA signal-to-noise ratio ≳10, establishing ATLAS J1013−4516 as a strong prospective LISA source that will probe long-term orbital evolution in the mass-transferring regime."}],"scopus_import":"1","status":"public","file":[{"success":1,"checksum":"c8f64a78f36224d8e0ea1f324e43e389","file_name":"2026_AstrophysicalJournal_Chickles.pdf","date_updated":"2026-05-04T06:36:00Z","content_type":"application/pdf","date_created":"2026-05-04T06:36:00Z","creator":"dernst","access_level":"open_access","file_id":"21782","relation":"main_file","file_size":1225916}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"article_type":"original","publication_status":"published","author":[{"first_name":"Emma T.","full_name":"Chickles, Emma T.","last_name":"Chickles"},{"last_name":"Chakraborty","first_name":"Joheen","full_name":"Chakraborty, Joheen"},{"last_name":"Burdge","full_name":"Burdge, Kevin B.","first_name":"Kevin B."},{"last_name":"Dhillon","full_name":"Dhillon, Vik S.","first_name":"Vik S."},{"last_name":"Draghis","full_name":"Draghis, Paul","first_name":"Paul"},{"first_name":"Kareem","full_name":"El-Badry, Kareem","last_name":"El-Badry"},{"last_name":"Green","full_name":"Green, Matthew J.","first_name":"Matthew J."},{"full_name":"Householder, Aaron","first_name":"Aaron","last_name":"Householder"},{"last_name":"Hughes","full_name":"Hughes, Sarah","first_name":"Sarah"},{"full_name":"Layden, Christopher","first_name":"Christopher","last_name":"Layden"},{"full_name":"Littlefair, Stuart P.","first_name":"Stuart P.","last_name":"Littlefair"},{"last_name":"Munday","full_name":"Munday, James","first_name":"James"},{"full_name":"Pelisoli, Ingrid","first_name":"Ingrid","last_name":"Pelisoli"},{"last_name":"Redden","first_name":"Maya S.","full_name":"Redden, Maya S."},{"full_name":"Tonry, John","first_name":"John","last_name":"Tonry"},{"first_name":"Joannes C","id":"4d122fc8-6083-11f0-87a5-97d68b860333","full_name":"van Roestel, Joannes C","last_name":"van Roestel"},{"full_name":"Angile, Francesco Elio","first_name":"Francesco Elio","last_name":"Angile"},{"last_name":"Brown","first_name":"Alex J.","full_name":"Brown, Alex J."},{"last_name":"Segura","full_name":"Segura, Noel Castro","first_name":"Noel Castro"},{"last_name":"Dinsmore","full_name":"Dinsmore, Jack","first_name":"Jack"},{"first_name":"Martin","full_name":"Dyer, Martin","last_name":"Dyer"},{"full_name":"Furesz, Gabor","first_name":"Gabor","last_name":"Furesz"},{"full_name":"Gabutti, Michelle","first_name":"Michelle","last_name":"Gabutti"},{"last_name":"Garbutt","full_name":"Garbutt, James","first_name":"James"},{"first_name":"Juliana","full_name":"García-Mejía, Juliana","last_name":"García-Mejía"},{"first_name":"Daniel","full_name":"Jarvis, Daniel","last_name":"Jarvis"},{"last_name":"Kennedy","full_name":"Kennedy, Mark R.","first_name":"Mark R."},{"full_name":"Kerry, Paul","first_name":"Paul","last_name":"Kerry"},{"last_name":"Mccormac","first_name":"James","full_name":"Mccormac, James"},{"first_name":"Geoffrey","full_name":"Mo, Geoffrey","last_name":"Mo"},{"last_name":"Osip","first_name":"Dave","full_name":"Osip, Dave"},{"last_name":"Parsons","first_name":"Steven","full_name":"Parsons, Steven"},{"last_name":"Pike","first_name":"Eleanor","full_name":"Pike, Eleanor"},{"first_name":"John J.","full_name":"Piotrowski, John J.","last_name":"Piotrowski"},{"last_name":"Romani","first_name":"Roger W.","full_name":"Romani, Roger W."},{"full_name":"Sahman, David","first_name":"David","last_name":"Sahman"},{"full_name":"Simcoe, Rob","first_name":"Rob","last_name":"Simcoe"}],"title":"An eclipsing 8.56 minutes orbital period mass-transferring binary","year":"2026","issue":"2","_id":"21705","oa_version":"Published Version","month":"04","article_processing_charge":"Yes"},{"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_number":"L18","department":[{"_id":"JoMa"}],"date_created":"2026-04-12T22:01:48Z","file_date_updated":"2026-05-04T07:11:37Z","external_id":{"arxiv":["2601.09778"]},"date_updated":"2026-05-04T07:13:07Z","OA_place":"publisher","has_accepted_license":"1","publication_identifier":{"issn":["2041-8205"],"eissn":["2041-8213"]},"intvolume":"      1000","language":[{"iso":"eng"}],"quality_controlled":"1","publication":"The Astrophysical Journal Letters","type":"journal_article","doi":"10.3847/2041-8213/ae4c88","publisher":"IOP Publishing","day":"20","volume":1000,"DOAJ_listed":"1","citation":{"ama":"Hviding RE, De Graaff A, Liu H, et al. The X-ray dot: Exotic dust or a late-stage Little Red Dot? <i>The Astrophysical Journal Letters</i>. 2026;1000(1). doi:<a href=\"https://doi.org/10.3847/2041-8213/ae4c88\">10.3847/2041-8213/ae4c88</a>","chicago":"Hviding, Raphael E., Anna De Graaff, Hanpu Liu, Andy D. Goulding, Yilun Ma, Jenny E. Greene, Leindert A. Boogaard, et al. “The X-Ray Dot: Exotic Dust or a Late-Stage Little Red Dot?” <i>The Astrophysical Journal Letters</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/2041-8213/ae4c88\">https://doi.org/10.3847/2041-8213/ae4c88</a>.","short":"R.E. Hviding, A. De Graaff, H. Liu, A.D. Goulding, Y. Ma, J.E. Greene, L.A. Boogaard, A.J. Bunker, N.J. Cleri, M. Franx, M. Hirschmann, J. Leja, J.J. Matthee, R.P. Naidu, D.J. Setton, H. Übler, G. Venturi, B. Wang, The Astrophysical Journal Letters 1000 (2026).","ieee":"R. E. Hviding <i>et al.</i>, “The X-ray dot: Exotic dust or a late-stage Little Red Dot?,” <i>The Astrophysical Journal Letters</i>, vol. 1000, no. 1. IOP Publishing, 2026.","apa":"Hviding, R. E., De Graaff, A., Liu, H., Goulding, A. D., Ma, Y., Greene, J. E., … Wang, B. (2026). The X-ray dot: Exotic dust or a late-stage Little Red Dot? <i>The Astrophysical Journal Letters</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/2041-8213/ae4c88\">https://doi.org/10.3847/2041-8213/ae4c88</a>","mla":"Hviding, Raphael E., et al. “The X-Ray Dot: Exotic Dust or a Late-Stage Little Red Dot?” <i>The Astrophysical Journal Letters</i>, vol. 1000, no. 1, L18, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/2041-8213/ae4c88\">10.3847/2041-8213/ae4c88</a>.","ista":"Hviding RE, De Graaff A, Liu H, Goulding AD, Ma Y, Greene JE, Boogaard LA, Bunker AJ, Cleri NJ, Franx M, Hirschmann M, Leja J, Matthee JJ, Naidu RP, Setton DJ, Übler H, Venturi G, Wang B. 2026. The X-ray dot: Exotic dust or a late-stage Little Red Dot? The Astrophysical Journal Letters. 1000(1), L18."},"oa":1,"file":[{"file_id":"21784","relation":"main_file","file_size":2821786,"content_type":"application/pdf","creator":"dernst","date_created":"2026-05-04T07:11:37Z","access_level":"open_access","file_name":"2026_AstrophysicalJourLetters_Hviding.pdf","date_updated":"2026-05-04T07:11:37Z","success":1,"checksum":"1be4f361bf59aa08b8c98ed4f475a463"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Hviding","full_name":"Hviding, Raphael E.","first_name":"Raphael E."},{"first_name":"Anna","full_name":"De Graaff, Anna","last_name":"De Graaff"},{"full_name":"Liu, Hanpu","first_name":"Hanpu","last_name":"Liu"},{"full_name":"Goulding, Andy D.","first_name":"Andy D.","last_name":"Goulding"},{"first_name":"Yilun","full_name":"Ma, Yilun","last_name":"Ma"},{"full_name":"Greene, Jenny E.","first_name":"Jenny E.","last_name":"Greene"},{"last_name":"Boogaard","first_name":"Leindert A.","full_name":"Boogaard, Leindert A."},{"first_name":"Andrew J.","full_name":"Bunker, Andrew J.","last_name":"Bunker"},{"last_name":"Cleri","first_name":"Nikko J.","full_name":"Cleri, Nikko J."},{"first_name":"Marijn","full_name":"Franx, Marijn","last_name":"Franx"},{"first_name":"Michaela","full_name":"Hirschmann, Michaela","last_name":"Hirschmann"},{"last_name":"Leja","first_name":"Joel","full_name":"Leja, Joel"},{"last_name":"Matthee","orcid":"0000-0003-2871-127X","id":"7439a258-f3c0-11ec-9501-9df22fe06720","full_name":"Matthee, Jorryt J","first_name":"Jorryt J"},{"first_name":"Rohan P.","full_name":"Naidu, Rohan P.","last_name":"Naidu"},{"full_name":"Setton, David J.","first_name":"David J.","last_name":"Setton"},{"last_name":"Übler","first_name":"Hannah","full_name":"Übler, Hannah"},{"full_name":"Venturi, Giacomo","first_name":"Giacomo","last_name":"Venturi"},{"last_name":"Wang","first_name":"Bingjie","full_name":"Wang, Bingjie"}],"publication_status":"published","article_type":"original","acknowledgement":"We would like to thank the anonymous reviewer for their constructive comments, which improved the final manuscript.\r\n\r\nWe thank Bernd Husemann for his critical contributions to the NIRSpec Wide GTO survey, and in particular his help in selecting high-priority X-ray-luminous targets.\r\n\r\nR.E.H. acknowledges support by the German Aerospace Center (DLR) and the Federal Ministry for Economic Affairs and Energy (BMWi) through program 50OR2403 “RUBIES.” A.d.G. acknowledges support from a Clay Fellowship awarded by the Smithsonian Astrophysical Observatory. A.J.B. acknowledges funding from the “FirstGalaxies” Advanced grant from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No. 789056). R.P.N. thanks Neil Pappalardo and Jane Pappalardo for their generous support of the MIT Pappalardo Fellowships in Physics. Support for this work was provided by the Brinson Foundation through a Brinson Prize Fellowship grant. H.Ü. acknowledges funding by the European Union (ERC APEX, 101164796). Views and opinions expressed are, however, those of the authors only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. G.V. acknowledges support from European Union’s HE ERC Starting grant No. 101040227—WINGS. B.W. acknowledges support provided by NASA through Hubble Fellowship grant HST-HF2-51592.001 awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, In., for NASA, under the contract NAS 5-26555.\r\n\r\nThe data products presented herein were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN).\r\n\r\nThis work is based in part on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs Nos. GTO-1213. The data described here may be obtained from the MAST archive at DOI: 10.17909/qffz-b324.\r\n\r\nThis Letter employs a list of Chandra datasets, obtained by the Chandra X-ray Observatory, contained in DOI: 10.25574/cdc.540.\r\n\r\nThis work is based on observations taken by the 3D-HST Treasury Program (GO 12177 and 12328) with the NASA/ESA HST, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.\r\n\r\nThis work makes use of color palettes created by Martin Krzywinski designed for colorblindness. The color palettes and more information can be found at http://mkweb.bcgsc.ca/colorblind/.\r\n\r\nFacilities: CXO - Chandra X-ray Observatory satellite (ACIS), HST - Hubble Space Telescope satellite (ACS, WFC3) - , CFHT - Canada-France-Hawaii Telescope (WIRCam), JWST - James Webb Space Telescope (NIRSpec), Spitzer - Spitzer Space Telescope satellite (IRAC, MIPS) - , JCMT - James Clerk Maxwell Telescope (SCUBA).\r\n\r\nSoftware: Astropy (Astropy Collaboration et al. 2013, 2018, 2022), dust_attenuation, dust_extinction (K. Gordon 2024), jax (J. Bradbury et al. 2018), LaTeX (L. Lamport 1994), Matplotlib (J. D. Hunter 2007), NumPy (T. E. Oliphant 2006; S. van der Walt et al. 2011; C. R. Harris et al. 2020), NumPyro (D. Phan et al. 2019), scipy (P. Virtanen et al. 2020), sedpy (B. Johnson & J. Leja 2017), specutils (Astropy-Specutils Development Team 2019), unite (R. E. Hviding 2025).","arxiv":1,"ddc":["520"],"OA_type":"gold","status":"public","abstract":[{"lang":"eng","text":"JWST’s “little red dots” (LRDs) are increasingly interpreted as active galactic nuclei (AGN) obscured by dense thermalized gas rather than dust as evidenced by their X-ray weakness, blackbody-like continua, and Balmer line profiles. Key questions are how LRDs connect to standard UV-luminous AGN, whether transitional phases exist, and whether they are observable. We present the “X-ray dot” (XRD), a compact source at z = 3.28 observed by the NIRSpec Wide Guaranteed Time Observation survey. The XRD exhibits LRD hallmarks: a blackbody-like (Teff ≃ 6400 K) red continuum, a faint but blue rest-UV excess, falling mid-IR emission, and broad Balmer lines (FWHM ∼ 2700–3200 km s−1). Unlike LRDs, however, it is remarkably X-ray luminous (L2−10 keV = 1044.18 erg s−1) and has a continuum inflection that is blueward of the Balmer limit. We find that the red rest-optical and blue mid-IR continuum cannot be reproduced by standard dust-attenuated AGN models without invoking extremely steep extinction curves, nor can the weak mid-IR emission be reconciled with well-established X-ray–torus scaling relations. We therefore consider an alternative scenario: the XRD may be an LRD in transition, where the gas envelope dominates the optical continuum but optically thin sight lines allow X-rays to escape. The XRD may thus provide a physical link between LRDs and standard AGN, offering direct evidence that LRDs are powered by supermassive black holes and providing insight into their accretion properties."}],"date_published":"2026-03-20T00:00:00Z","scopus_import":"1","month":"03","article_processing_charge":"Yes","title":"The X-ray dot: Exotic dust or a late-stage Little Red Dot?","oa_version":"Published Version","year":"2026","issue":"1","_id":"21709"},{"abstract":[{"text":"How functional protein sequences are distributed in sequence space is fundamentally important for evolutionary theory and protein design, particularly if a large diversity of protein functions are hidden in evolutionarily unexplored areas of the sequence space. However, this question is understudied in part because experimental and computational studies use extant sequences as a starting point to study sequence space. Here, we study whether extant sequences are representative of the entire functional sequence space. Across thousands of protein families from vertebrates and bacteria we calculate the dimensionality and the volume of sequence space occupied by extant homologs. We find that the observed dimensionality and volume of extant sequence space are minuscule, many orders of magnitude smaller than what we estimated using a model of protein evolution. Simulating sequence evolution we then quantify the impact of phylogeny, selection, and epistasis on restricting the evolutionary exploration of sequence space. We find that sequence evolution from a single common ancestor, or a single point of origin in sequence space, is by far the largest limiting factor that reduces the dimensionality and volume of extant sequence space. These results indicate that there are vast areas of functional sequence space that have not been explored in evolution because of the excessive restrictions on natural exploration of the protein sequence space imposed by the point of origin effect. We suggest that protein design methods that rely on extant sequences may be limited in their ability to discover truly novel functions.","lang":"eng"}],"date_published":"2026-04-07T00:00:00Z","scopus_import":"1","status":"public","OA_type":"hybrid","ddc":["570"],"acknowledgement":"We thank Olga Kalinina for feedback on our manuscript, Vsevolod Kuksin for fruitful discussions and Lev Tsarin for participation in the design of our models. This work was supported by Japan Science and Technology Agency as part of Adopting Sustainable Partnerships for Innovative Research Ecosystem, Grant No. JPMJAP24B2 (F.A.K. and L.H.I.), and Fonds Zur Förderung der Wissenschaftlichen Forschung Grant ESP253-B (O.O.B.)","publication_status":"published","article_type":"original","author":[{"last_name":"Isakova","full_name":"Isakova, Lada H.","first_name":"Lada H."},{"first_name":"Elizaveta","id":"57a170da-dc96-11ea-b7c8-ab3565071bf7","full_name":"Streltsova, Elizaveta","last_name":"Streltsova"},{"first_name":"Olga","full_name":"Bochkareva, Olga","id":"C4558D3C-6102-11E9-A62E-F418E6697425","orcid":"0000-0003-1006-6639","last_name":"Bochkareva"},{"last_name":"Vlasov","first_name":"Peter K.","full_name":"Vlasov, Peter K."},{"last_name":"Kondrashov","orcid":"0000-0001-8243-4694","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","full_name":"Kondrashov, Fyodor","first_name":"Fyodor"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"date_created":"2026-05-04T06:46:31Z","creator":"dernst","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_size":3355016,"file_id":"21783","checksum":"11b7a13a359e302498b2367906093a6b","success":1,"file_name":"2026_PNAS_Isakova.pdf","date_updated":"2026-05-04T06:46:31Z"}],"oa":1,"issue":"14","_id":"21704","year":"2026","oa_version":"Published Version","title":"Descent from a common ancestor restricts exploration of protein sequence space","article_processing_charge":"Yes (in subscription journal)","pmid":1,"month":"04","quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"       123","publication_identifier":{"eissn":["1091-6490"]},"OA_place":"publisher","has_accepted_license":"1","date_updated":"2026-05-04T06:57:31Z","external_id":{"pmid":["41915737"]},"date_created":"2026-04-12T22:01:47Z","file_date_updated":"2026-05-04T06:46:31Z","department":[{"_id":"UlWa"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"citation":{"ama":"Isakova LH, Streltsova E, Bochkareva O, Vlasov PK, Kondrashov F. Descent from a common ancestor restricts exploration of protein sequence space. <i>Proceedings of the National Academy of Sciences</i>. 2026;123(14):e2532018123. doi:<a href=\"https://doi.org/10.1073/pnas.2532018123\">10.1073/pnas.2532018123</a>","chicago":"Isakova, Lada H., Elizaveta Streltsova, Olga Bochkareva, Peter K. Vlasov, and Fyodor Kondrashov. “Descent from a Common Ancestor Restricts Exploration of Protein Sequence Space.” <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences, 2026. <a href=\"https://doi.org/10.1073/pnas.2532018123\">https://doi.org/10.1073/pnas.2532018123</a>.","short":"L.H. Isakova, E. Streltsova, O. Bochkareva, P.K. Vlasov, F. Kondrashov, Proceedings of the National Academy of Sciences 123 (2026) e2532018123.","ieee":"L. H. Isakova, E. Streltsova, O. Bochkareva, P. K. Vlasov, and F. Kondrashov, “Descent from a common ancestor restricts exploration of protein sequence space,” <i>Proceedings of the National Academy of Sciences</i>, vol. 123, no. 14. National Academy of Sciences, p. e2532018123, 2026.","mla":"Isakova, Lada H., et al. “Descent from a Common Ancestor Restricts Exploration of Protein Sequence Space.” <i>Proceedings of the National Academy of Sciences</i>, vol. 123, no. 14, National Academy of Sciences, 2026, p. e2532018123, doi:<a href=\"https://doi.org/10.1073/pnas.2532018123\">10.1073/pnas.2532018123</a>.","ista":"Isakova LH, Streltsova E, Bochkareva O, Vlasov PK, Kondrashov F. 2026. Descent from a common ancestor restricts exploration of protein sequence space. Proceedings of the National Academy of Sciences. 123(14), e2532018123.","apa":"Isakova, L. H., Streltsova, E., Bochkareva, O., Vlasov, P. K., &#38; Kondrashov, F. (2026). Descent from a common ancestor restricts exploration of protein sequence space. <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2532018123\">https://doi.org/10.1073/pnas.2532018123</a>"},"volume":123,"doi":"10.1073/pnas.2532018123","publisher":"National Academy of Sciences","day":"07","page":"e2532018123","type":"journal_article","publication":"Proceedings of the National Academy of Sciences"},{"publication_status":"published","article_type":"original","author":[{"last_name":"Mohanty","full_name":"Mohanty, Litan Kumar","first_name":"Litan Kumar"},{"last_name":"Gantayat","first_name":"Prateek","id":"02734268-3e8d-11ef-80a1-cec4a088d004","full_name":"Gantayat, Prateek"},{"last_name":"Dixit","full_name":"Dixit, Ankur","first_name":"Ankur"},{"first_name":"Manik","full_name":"Das Adhikari, Manik","last_name":"Das Adhikari"},{"first_name":"Rahul","full_name":"Biswas, Rahul","last_name":"Biswas"},{"full_name":"Singh, Vivek Kumar","first_name":"Vivek Kumar","last_name":"Singh"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"success":1,"checksum":"cf13f61c38609ce6518d74562319c35f","file_name":"2026_ScienceAdv_Mohanty.pdf","date_updated":"2026-05-04T07:24:59Z","content_type":"application/pdf","creator":"dernst","date_created":"2026-05-04T07:24:59Z","access_level":"open_access","file_id":"21785","relation":"main_file","file_size":17406006}],"oa":1,"abstract":[{"text":"On October 4, 2023, a proglacial lake named the South Lhonak lake was the source of a catastrophic Glacier Lake Outburst Flood (GLOF) in the Teesta river basin area, resulting in 24 fatalities and leaving over 70 persons missing. The GLOF also destroyed 13 bridges and a major hydropower plant in the Chungthang region. Over 60,000 individuals in four districts of Sikkim were impacted by this GLOF event. This study examines the factors that led to the GLOF event. Our study shows that the cause of this GLOF was initiated by a landslide, that dumped a substantial amount (~ 38.31 million m3) of debris into the South Lhonak Lake. Furthermore, the glacier that was connected to the lake, lost a big chunk of ice mass (~ 7 million m3) due to calving. The combination of these two processes led to the collapse of the left lateral moraine that consequently generated flood waves which breached the terminal moraine dam of the lake. We recommend monitoring land subsidence and calving events for large proglacial lakes to prevent the disastrous consequences of such GLOFs in the future.","lang":"eng"}],"scopus_import":"1","date_published":"2026-03-24T00:00:00Z","status":"public","OA_type":"gold","ddc":["550"],"acknowledgement":"This work was carried out independently without the support of any funding agency or sponsors. The authors thank the SARPROZ team for providing an evaluation license for the MTInSAR processing software.","article_processing_charge":"Yes","pmid":1,"month":"03","_id":"21708","year":"2026","oa_version":"Published Version","title":"Sequence of events that led to the South Lhonak lake outburst flood in Sikkim, India","file_date_updated":"2026-05-04T07:24:59Z","date_created":"2026-04-12T22:01:48Z","department":[{"_id":"FrPe"}],"article_number":"9741","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"        16","publication_identifier":{"eissn":["2045-2322"]},"has_accepted_license":"1","OA_place":"publisher","date_updated":"2026-05-04T07:54:53Z","corr_author":"1","external_id":{"pmid":["41876546"]},"publication":"Scientific Reports","DOAJ_listed":"1","citation":{"short":"L.K. Mohanty, P. GANTAYAT, A. Dixit, M. Das Adhikari, R. Biswas, V.K. Singh, Scientific Reports 16 (2026).","ieee":"L. K. Mohanty, P. GANTAYAT, A. Dixit, M. Das Adhikari, R. Biswas, and V. K. Singh, “Sequence of events that led to the South Lhonak lake outburst flood in Sikkim, India,” <i>Scientific Reports</i>, vol. 16. Springer Nature, 2026.","mla":"Mohanty, Litan Kumar, et al. “Sequence of Events That Led to the South Lhonak Lake Outburst Flood in Sikkim, India.” <i>Scientific Reports</i>, vol. 16, 9741, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41598-026-35895-7\">10.1038/s41598-026-35895-7</a>.","apa":"Mohanty, L. K., GANTAYAT, P., Dixit, A., Das Adhikari, M., Biswas, R., &#38; Singh, V. K. (2026). Sequence of events that led to the South Lhonak lake outburst flood in Sikkim, India. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-026-35895-7\">https://doi.org/10.1038/s41598-026-35895-7</a>","ista":"Mohanty LK, GANTAYAT P, Dixit A, Das Adhikari M, Biswas R, Singh VK. 2026. Sequence of events that led to the South Lhonak lake outburst flood in Sikkim, India. Scientific Reports. 16, 9741.","ama":"Mohanty LK, GANTAYAT P, Dixit A, Das Adhikari M, Biswas R, Singh VK. Sequence of events that led to the South Lhonak lake outburst flood in Sikkim, India. <i>Scientific Reports</i>. 2026;16. doi:<a href=\"https://doi.org/10.1038/s41598-026-35895-7\">10.1038/s41598-026-35895-7</a>","chicago":"Mohanty, Litan Kumar, PRATEEK GANTAYAT, Ankur Dixit, Manik Das Adhikari, Rahul Biswas, and Vivek Kumar Singh. “Sequence of Events That Led to the South Lhonak Lake Outburst Flood in Sikkim, India.” <i>Scientific Reports</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41598-026-35895-7\">https://doi.org/10.1038/s41598-026-35895-7</a>."},"volume":16,"day":"24","publisher":"Springer Nature","doi":"10.1038/s41598-026-35895-7","type":"journal_article"},{"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"VeSu"}],"article_number":"2604.07653","author":[{"last_name":"Alex Liebman-Peláez","full_name":"Alex Liebman-Peláez, Alex Liebman-Peláez","first_name":"Alex Liebman-Peláez"},{"last_name":"Kruppe","full_name":"Kruppe, Jon","first_name":"Jon"},{"first_name":"Resham Babu","full_name":"Regmi, Resham Babu","last_name":"Regmi"},{"last_name":"Ghimire","first_name":"Nirmal J.","full_name":"Ghimire, Nirmal J."},{"first_name":"Yue","full_name":"Sun, Yue","last_name":"Sun"},{"full_name":"Mazin, Igor I.","first_name":"Igor I.","last_name":"Mazin"},{"last_name":"Noad","full_name":"Noad, Hilary M. L.","first_name":"Hilary M. L."},{"first_name":"James","full_name":"Analytis, James","last_name":"Analytis"},{"orcid":"0000-0003-2724-3523","last_name":"Sunko","first_name":"Veronika","full_name":"Sunko, Veronika","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3"},{"full_name":"Orenstein, Joseph","first_name":"Joseph","last_name":"Orenstein"}],"date_created":"2026-04-10T14:17:21Z","publication_status":"submitted","arxiv":1,"acknowledgement":"This research was primarily funded by the Quantum Materials (KC2202) program under the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division under Contract No. DE-AC02-05CH11231, which supported the experimental and theoretical work at the LBNL and UC Berkeley. N.J.G., R. B. R., and I.I.M.\r\nwere supported by Army Research Office under Cooperative Agreement Number W911NF- 22-2-0173. H.M.L.N. and V.S. acknowledge funding through the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through Grant No. TRR288—422213477, Project No. A10. H.M.L.N. acknowledges financial support from the Max Planck Society. Research in Dresden benefits from the environment provided by the DFG Cluster of Excellence ctd.qmat (EXC2147, Project ID 390858490).","external_id":{"arxiv":["2604.07653"]},"OA_type":"green","OA_place":"repository","date_updated":"2026-05-04T06:27:12Z","status":"public","date_published":"2026-04-08T00:00:00Z","language":[{"iso":"eng"}],"abstract":[{"text":"Altermagnetism has recently emerged as a distinct class of collinear antiferromagnets that break time-reversal symmetry, exhibiting a host of novel properties. Applied strain has attracted particular attention as a key tuning parameter for altermagnets. Although several experimental studies have demonstrated the preparation of single-domain states through a combination of applied strain and magnetic field, the route to such states remains unclear. Here, we use magneto-optical measurements on single crystals of MnTe under applied strain to show that, in contrast to previous reports, strain acts primarily to rotate the Néel vector L continuously. Since the orientation of L determines the magnetic point group symmetry, this continuous rotation effectively tunes the symmetry and its associated physical properties. Furthermore, we demonstrate that built-in strain in free-standing crystals is sufficient to pin L into continuous textures over millimeter length scales. Together, these results provide guidance for future device design and open the door to leveraging the Néel vector orientation as a tunable degree of freedom in spintronic applications.","lang":"eng"}],"month":"04","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2604.07653"}],"article_processing_charge":"No","publication":"arXiv","type":"preprint","title":"Strain continuously rotates the Néel vector in altermagnetic MnTe","doi":"10.48550/arXiv.2604.07653","day":"08","oa_version":"Preprint","_id":"21703","citation":{"short":"A.L.-P. Alex Liebman-Peláez, J. Kruppe, R.B. Regmi, N.J. Ghimire, Y. Sun, I.I. Mazin, H.M.L. Noad, J. Analytis, V. Sunko, J. Orenstein, ArXiv (n.d.).","mla":"Alex Liebman-Peláez, Alex Liebman-Peláez, et al. “Strain Continuously Rotates the Néel Vector in Altermagnetic MnTe.” <i>ArXiv</i>, 2604.07653, doi:<a href=\"https://doi.org/10.48550/arXiv.2604.07653\">10.48550/arXiv.2604.07653</a>.","apa":"Alex Liebman-Peláez, A. L.-P., Kruppe, J., Regmi, R. B., Ghimire, N. J., Sun, Y., Mazin, I. I., … Orenstein, J. (n.d.). Strain continuously rotates the Néel vector in altermagnetic MnTe. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2604.07653\">https://doi.org/10.48550/arXiv.2604.07653</a>","ista":"Alex Liebman-Peláez AL-P, Kruppe J, Regmi RB, Ghimire NJ, Sun Y, Mazin II, Noad HML, Analytis J, Sunko V, Orenstein J. Strain continuously rotates the Néel vector in altermagnetic MnTe. arXiv, 2604.07653.","ieee":"A. L.-P. Alex Liebman-Peláez <i>et al.</i>, “Strain continuously rotates the Néel vector in altermagnetic MnTe,” <i>arXiv</i>. .","ama":"Alex Liebman-Peláez AL-P, Kruppe J, Regmi RB, et al. Strain continuously rotates the Néel vector in altermagnetic MnTe. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2604.07653\">10.48550/arXiv.2604.07653</a>","chicago":"Alex Liebman-Peláez, Alex Liebman-Peláez, Jon Kruppe, Resham Babu Regmi, Nirmal J. Ghimire, Yue Sun, Igor I. Mazin, Hilary M. L. Noad, James Analytis, Veronika Sunko, and Joseph Orenstein. “Strain Continuously Rotates the Néel Vector in Altermagnetic MnTe.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2604.07653\">https://doi.org/10.48550/arXiv.2604.07653</a>."},"year":"2026"},{"date_published":"2026-03-01T00:00:00Z","abstract":[{"text":"Background: Low-volume trapping columns are essential for sample enrichment, desalting, and injection profile focusing on nano-LC–MS-based proteomics. They enable higher sample loading, improve chromatographic performance, and protect the analytical column by removing salts and contaminants. Recently, monolithic trap columns with micropillar architecture have emerged as alternatives to conventionally packed traps. This study compares the performance of a packed and a micropillar monolithic trap column for the analysis of tryptic peptides. Methods: A tryptic digest of HeLa cell lysate was analyzed under identical LC–MS conditions using both trap types. Peptides were detected at 214 nm and analyzed by nano-ESI on a Q Exactive Plus Orbitrap. Data were searched against the human UniProt database (February 2023) using FragPipe v20.0, and statistical evaluation of MaxLFQ intensities was performed in Perseus using Welch’s t-test and clustering analysis. Results: Over 2500 proteins were identified with both setups. The packed trap column yielded more total peptides, particularly those with post-translational modifications and higher hydrophilicity, whereas the monolithic column favored peptides of intermediate hydrophobicity. Chromatographic profiles confirmed a slight reduction in the trapping efficiency of hydrophilic peptides by the monolithic trap. Conclusions: Trap column design significantly influences peptide recovery and proteome coverage.","lang":"eng"}],"scopus_import":"1","status":"public","OA_type":"gold","acknowledgement":"The authors thank Gábor Tóth, Uppsala University, Sweden, and Armel Nicolas, Institute for Science and Technology Austria, for their support. This research was conducted during a student residency in Vienna under the auspices of OeAD. ZI: ICM-2016-03196.","ddc":["540"],"publication_status":"published","article_type":"original","author":[{"full_name":"Miletić Vukajlović, Jadranka","first_name":"Jadranka","last_name":"Miletić Vukajlović"},{"first_name":"Bojana","full_name":"Ilić, Bojana","last_name":"Ilić"},{"first_name":"Bella","full_name":"Bruszel, Bella","id":"70abbbb3-88ea-11ec-8e0a-e8c939944834","last_name":"Bruszel"},{"last_name":"Panić-Janković","first_name":"Tanja","full_name":"Panić-Janković, Tanja"},{"full_name":"Mitulović, Goran","first_name":"Goran","last_name":"Mitulović"}],"file":[{"file_id":"21790","relation":"main_file","file_size":1009723,"content_type":"application/pdf","access_level":"open_access","date_created":"2026-05-04T10:31:35Z","creator":"dernst","date_updated":"2026-05-04T10:31:35Z","file_name":"2026_Proteomes_Vukajlovic.pdf","success":1,"checksum":"1e0c66bbf4b6e0be626a8639ea664b63"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"year":"2026","issue":"1","_id":"21711","oa_version":"Published Version","title":"Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses","article_processing_charge":"Yes","pmid":1,"month":"03","intvolume":"        14","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"eissn":["2227-7382"]},"date_updated":"2026-05-04T10:36:21Z","has_accepted_license":"1","OA_place":"publisher","external_id":{"pmid":["41893725"]},"file_date_updated":"2026-05-04T10:31:35Z","date_created":"2026-04-12T22:01:49Z","article_number":"10","department":[{"_id":"MassSpec"}],"PlanS_conform":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"DOAJ_listed":"1","citation":{"ieee":"J. Miletić Vukajlović, B. Ilić, B. Bruszel, T. Panić-Janković, and G. Mitulović, “Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses,” <i>Proteomes</i>, vol. 14, no. 1. MDPI, 2026.","apa":"Miletić Vukajlović, J., Ilić, B., Bruszel, B., Panić-Janković, T., &#38; Mitulović, G. (2026). Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses. <i>Proteomes</i>. MDPI. <a href=\"https://doi.org/10.3390/proteomes14010010\">https://doi.org/10.3390/proteomes14010010</a>","mla":"Miletić Vukajlović, Jadranka, et al. “Comparison of the Trapping Efficiency for Tryptic Peptides on Particle-Packed and Micro-Pillar Trap Columns for Proteomics Analyses.” <i>Proteomes</i>, vol. 14, no. 1, 10, MDPI, 2026, doi:<a href=\"https://doi.org/10.3390/proteomes14010010\">10.3390/proteomes14010010</a>.","ista":"Miletić Vukajlović J, Ilić B, Bruszel B, Panić-Janković T, Mitulović G. 2026. Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses. Proteomes. 14(1), 10.","short":"J. Miletić Vukajlović, B. Ilić, B. Bruszel, T. Panić-Janković, G. Mitulović, Proteomes 14 (2026).","chicago":"Miletić Vukajlović, Jadranka, Bojana Ilić, Bella Bruszel, Tanja Panić-Janković, and Goran Mitulović. “Comparison of the Trapping Efficiency for Tryptic Peptides on Particle-Packed and Micro-Pillar Trap Columns for Proteomics Analyses.” <i>Proteomes</i>. MDPI, 2026. <a href=\"https://doi.org/10.3390/proteomes14010010\">https://doi.org/10.3390/proteomes14010010</a>.","ama":"Miletić Vukajlović J, Ilić B, Bruszel B, Panić-Janković T, Mitulović G. Comparison of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar trap columns for proteomics analyses. <i>Proteomes</i>. 2026;14(1). doi:<a href=\"https://doi.org/10.3390/proteomes14010010\">10.3390/proteomes14010010</a>"},"volume":14,"doi":"10.3390/proteomes14010010","publisher":"MDPI","day":"01","type":"journal_article","publication":"Proteomes"},{"intvolume":"       997","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"date_updated":"2026-05-04T10:26:59Z","OA_place":"publisher","has_accepted_license":"1","date_created":"2026-04-12T22:01:49Z","file_date_updated":"2026-05-04T10:24:49Z","article_number":"316","department":[{"_id":"ZoHa"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"DOAJ_listed":"1","citation":{"ieee":"A. Lin, M. Charisi, and Z. Haiman, “Lomb-scargle periodogram struggles with non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves,” <i>The Astrophysical Journal</i>, vol. 997, no. 2. IOP Publishing, 2026.","ista":"Lin A, Charisi M, Haiman Z. 2026. Lomb-scargle periodogram struggles with non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves. The Astrophysical Journal. 997(2), 316.","apa":"Lin, A., Charisi, M., &#38; Haiman, Z. (2026). Lomb-scargle periodogram struggles with non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ae29a7\">https://doi.org/10.3847/1538-4357/ae29a7</a>","mla":"Lin, Allison, et al. “Lomb-Scargle Periodogram Struggles with Non-Sinusoidal Supermassive Black Hole Binary Signatures in Quasar Lightcurves.” <i>The Astrophysical Journal</i>, vol. 997, no. 2, 316, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/1538-4357/ae29a7\">10.3847/1538-4357/ae29a7</a>.","short":"A. Lin, M. Charisi, Z. Haiman, The Astrophysical Journal 997 (2026).","chicago":"Lin, Allison, Maria Charisi, and Zoltán Haiman. “Lomb-Scargle Periodogram Struggles with Non-Sinusoidal Supermassive Black Hole Binary Signatures in Quasar Lightcurves.” <i>The Astrophysical Journal</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/1538-4357/ae29a7\">https://doi.org/10.3847/1538-4357/ae29a7</a>.","ama":"Lin A, Charisi M, Haiman Z. Lomb-scargle periodogram struggles with non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves. <i>The Astrophysical Journal</i>. 2026;997(2). doi:<a href=\"https://doi.org/10.3847/1538-4357/ae29a7\">10.3847/1538-4357/ae29a7</a>"},"volume":997,"publisher":"IOP Publishing","day":"01","doi":"10.3847/1538-4357/ae29a7","type":"journal_article","publication":"The Astrophysical Journal","abstract":[{"lang":"eng","text":"Supermassive black hole binary (SMBHB) systems are expected to form as a consequence of galaxy mergers. At subparsec separations, SMBHBs can be identified as quasars with periodic variability, with previous periodicity searches uncovering significant candidates. However, these searches focused primarily on sinusoidal signals, while theoretical models and hydrodynamical simulations predict that binaries produce more complex non-sinusoidal pulse shapes. Here we examine the efficacy of the Lomb–Scargle periodogram (LSP; one of the most popular tools for periodicity searches in unevenly sampled lightcurves) to detect periodicities with a sawtooth shape mimicking results of hydrodynamical simulations. We simulate idealized well-sampled lightcurves, lightcurves that mimic the data in the Palomar Transient Factory (PTF) analyzed in M. Charisi et al. (2016), and lightcurves that resemble our expectations for single-band data in the upcoming Legacy Survey of Space and Time (LSST) of the Rubin Observatory. We approximate quasar variability with a damped random walk (DRW) model, inject sinusoidal and sawtooth pulse shapes, and assess their statistical significance. We find that in the presence of red noise, the LSP detects a relatively low fraction of the sinusoidal signals (∼45%, ∼24%, and ∼23%, in the PTF-like, idealized, and LSST-like lightcurves, respectively). The fraction is significantly reduced for sawtooth periodicity (with only ∼9% in PTF-like and ∼1% in idealized and LSST-like lightcurves). These low recovery rates imply that previous searches have missed the large majority of binaries. They also have significant implications for the detection of SMBHBs in upcoming LSST necessitating the development of advanced tools that go beyond the simple LSP."}],"date_published":"2026-02-01T00:00:00Z","scopus_import":"1","status":"public","OA_type":"gold","acknowledgement":"M.C. acknowledges support by the European Union (ERC; MMMonsters, 101117624). This work was also supported in part by NASA grants 80NSSC24K0440 and 80NSSC22K0822. This research used the resources of the Center for Institutional Research Computing at Washington State University.","ddc":["520"],"article_type":"original","publication_status":"published","author":[{"full_name":"Lin, Allison","first_name":"Allison","last_name":"Lin"},{"last_name":"Charisi","first_name":"Maria","full_name":"Charisi, Maria"},{"orcid":"0000-0003-3633-5403","last_name":"Haiman","full_name":"Haiman, Zoltán","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","first_name":"Zoltán"}],"file":[{"date_updated":"2026-05-04T10:24:49Z","file_name":"2026_AstrophysicalJour_Lin.pdf","success":1,"checksum":"5162d1539ef7d10927ef73d8b4500017","file_id":"21789","relation":"main_file","file_size":2619679,"content_type":"application/pdf","access_level":"open_access","creator":"dernst","date_created":"2026-05-04T10:24:49Z"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"year":"2026","_id":"21712","issue":"2","oa_version":"Published Version","title":"Lomb-scargle periodogram struggles with non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves","article_processing_charge":"Yes","month":"02"},{"date_updated":"2026-05-04T09:18:06Z","OA_place":"publisher","has_accepted_license":"1","publication_identifier":{"eissn":["2375-2548"]},"intvolume":"        12","language":[{"iso":"eng"}],"quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_number":"eaea6020","department":[{"_id":"MiSi"},{"_id":"GradSch"}],"date_created":"2026-04-12T22:01:48Z","file_date_updated":"2026-05-04T09:16:36Z","type":"journal_article","doi":"10.1126/sciadv.aea6020","publisher":"American Association for the Advancement of Science","day":"27","volume":12,"DOAJ_listed":"1","citation":{"chicago":"Markovitsch, Johann W., Daniel Mitić, Alisa Del Pilar Jiménez García, Alsberga Zane, Sarah Kainz, Rashmit Kaur, and Thomas Hummel. “Sequential Formation of Drosophila Circuit Asymmetry via Prolonged Structural Plasticity.” <i>Science Advances</i>. American Association for the Advancement of Science, 2026. <a href=\"https://doi.org/10.1126/sciadv.aea6020\">https://doi.org/10.1126/sciadv.aea6020</a>.","ama":"Markovitsch JW, Mitić D, Del Pilar Jiménez García A, et al. Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity. <i>Science Advances</i>. 2026;12(13). doi:<a href=\"https://doi.org/10.1126/sciadv.aea6020\">10.1126/sciadv.aea6020</a>","ieee":"J. W. Markovitsch <i>et al.</i>, “Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity,” <i>Science Advances</i>, vol. 12, no. 13. American Association for the Advancement of Science, 2026.","apa":"Markovitsch, J. W., Mitić, D., Del Pilar Jiménez García, A., Zane, A., Kainz, S., Kaur, R., &#38; Hummel, T. (2026). Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aea6020\">https://doi.org/10.1126/sciadv.aea6020</a>","mla":"Markovitsch, Johann W., et al. “Sequential Formation of Drosophila Circuit Asymmetry via Prolonged Structural Plasticity.” <i>Science Advances</i>, vol. 12, no. 13, eaea6020, American Association for the Advancement of Science, 2026, doi:<a href=\"https://doi.org/10.1126/sciadv.aea6020\">10.1126/sciadv.aea6020</a>.","ista":"Markovitsch JW, Mitić D, Del Pilar Jiménez García A, Zane A, Kainz S, Kaur R, Hummel T. 2026. Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity. Science Advances. 12(13), eaea6020.","short":"J.W. Markovitsch, D. Mitić, A. Del Pilar Jiménez García, A. Zane, S. Kainz, R. Kaur, T. Hummel, Science Advances 12 (2026)."},"publication":"Science Advances","acknowledgement":"We thank I. Salecker (Flybow), B. Altenhein (Fas2-Gal4Mz507), A. Nose (UAS-intra- and extra-Fas2::YFP), and C. S. Goodman (UAS-Fas2PEST+/−), as well as the Bloomington Stock Center for providing materials and fly stocks. We thank S. Waddell and the lab, especially B. Senapati, for providing the opportunity to conduct memory experiments at the CNCB, University of Oxford, and for supervision and discussions during this period. We also thank W. Kallina, S. Ilgerl, D. Bartel, A. Grimm, and A. Litin for technical support and the Hummel Lab for stimulating discussions and critical comments on the manuscript. We acknowledge the early exploratory work of A. Mattia, S. Trkulja, C. Schönherr, S. Bogner, B. Simpson, L. Tomasek, H. Roth, H. Vokač, R. Gredler, F. Kapelari, T. Kolarova, C. Ignitsch, Á. Bautista-Soldevila, and M. Kassem.\r\nThis research was funded by the University of Vienna, the Vienna Doctoral School Cognition, Behaviour and Neuroscience (uni:docs fellowship) (to J.W.M.) and by the Austrian Science Fund (FWF) (Cluster of Excellence Neuronal Circuits in Health and Disease, grant DOI 10.55776/COE16; https://www.fwf.ac.at/en/research-radar/10.55776/COE16) (to T.H.). For open access purposes, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission.","ddc":["570"],"OA_type":"gold","status":"public","abstract":[{"text":"Structural and functional differences between brain hemispheres are a common feature of animal nervous systems with reduced bilateral asymmetry often linked to impaired cognitive performance. How neuronal left-right asymmetry is initiated and integrated into a bilaterally symmetrical ground pattern is poorly understood. Here, we show that the directional asymmetry of a Drosophila central brain circuit originates from axonal interactions of two types of bilateral pioneer neurons. Subsequent recruitment of neighboring neurons into the asymmetric neuropil primordium results in hemisphere-specific microcircuits. Circuit lateralization requires dynamic expression of the cell adhesion molecule Fasciclin 2 to maintain structural plasticity in axonal remodeling. Reduced circuit asymmetry following cell type–specific Fasciclin 2 manipulation affects adult brain function. These results reveal an unexpected degree of developmental plasticity of late-born Drosophila neurons in the formation of a circuit node via the lateralized recruitment of symmetric circuit components.","lang":"eng"}],"date_published":"2026-03-27T00:00:00Z","scopus_import":"1","oa":1,"file":[{"date_updated":"2026-05-04T09:16:36Z","file_name":"2026_ScienceAdv_Markovitsch.pdf","success":1,"checksum":"3eed470fe73e53d2a8d55d6fba6934e3","file_id":"21786","relation":"main_file","file_size":11101140,"content_type":"application/pdf","access_level":"open_access","date_created":"2026-05-04T09:16:36Z","creator":"dernst"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Markovitsch, Johann W.","first_name":"Johann W.","last_name":"Markovitsch"},{"last_name":"Mitić","first_name":"Daniel","full_name":"Mitić, Daniel"},{"last_name":"Del Pilar Jiménez García","first_name":"Alisa","full_name":"Del Pilar Jiménez García, Alisa"},{"first_name":"Alsberga","full_name":"Zane, Alsberga","id":"60f7509a-f652-11ea-9d86-b963d6490d7c","last_name":"Zane","orcid":"0009-0003-0415-7603"},{"first_name":"Sarah","full_name":"Kainz, Sarah","last_name":"Kainz"},{"full_name":"Kaur, Rashmit","first_name":"Rashmit","last_name":"Kaur"},{"last_name":"Hummel","first_name":"Thomas","full_name":"Hummel, Thomas"}],"article_type":"original","publication_status":"published","title":"Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity","oa_version":"Published Version","year":"2026","_id":"21707","issue":"13","month":"03","article_processing_charge":"Yes"},{"author":[{"first_name":"Imre","full_name":"Bartos, Imre","last_name":"Bartos"},{"orcid":"0000-0003-3633-5403","last_name":"Haiman","first_name":"Zoltán","full_name":"Haiman, Zoltán","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36"}],"publication_status":"published","article_type":"original","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"success":1,"checksum":"ac46ba3d13f0150ccbc42665bed3ae47","date_updated":"2026-05-04T09:49:53Z","file_name":"2026_AstrophysicalJourLetters_Bartos.pdf","content_type":"application/pdf","access_level":"open_access","creator":"dernst","date_created":"2026-05-04T09:49:53Z","file_id":"21788","file_size":866725,"relation":"main_file"}],"status":"public","date_published":"2026-01-10T00:00:00Z","abstract":[{"lang":"eng","text":"GW231123 represents the most massive binary–black hole merger detected to date, lying firmly within, or even above, the pair-instability mass gap. The component spins are both exceptionally high (a1 = 0.90 +0.10/-0.19, a2 = 0.80 +0.20/-0.51), which is difficult to explain with repeated mergers. Here we show that the black hole spin vectors are closely aligned with each other while significantly tilted relative to the binary’s orbital angular momentum, pointing to a common accretion-driven origin. We examine astrophysical formation channels capable of producing near-equal, high-mass, and mutually aligned spins consistent with GW231123—particularly binaries embedded in AGN disks and Population III remnants, which grew via coherent misaligned gas accretion. We further argue that other high-mass, high-spin events, e.g., GW190521, may share a similar evolutionary pathway. These findings underscore the critical role of sustained, coherent accretion in shaping the most extreme black hole binaries."}],"scopus_import":"1","ddc":["520"],"arxiv":1,"acknowledgement":"The authors thank Davide Gerosa and Matthew Mould for valuable suggestions. We are grateful for support by the National Science Foundation under grant No. PHY-2309024 (I.B.) and by NASA under grants 80NSSC22K0822 and 80NSSC24K0440 (Z.H.). We used OpenAI’s ChatGPT (OpenAI 2025) during the preparation of this manuscript. This material is based upon work supported by NSF’s LIGO Laboratory, which is a major facility fully funded by the National Science Foundation.","OA_type":"gold","article_processing_charge":"Yes","month":"01","oa_version":"Published Version","_id":"21713","issue":"2","year":"2026","title":"Accretion is all you need: Black Hole spin alignment in merger GW231123 indicates accretion pathway","department":[{"_id":"ZoHa"}],"article_number":"L44","date_created":"2026-04-12T22:01:49Z","file_date_updated":"2026-05-04T09:49:53Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"publication_identifier":{"eissn":["2041-8213"],"issn":["2041-8205"]},"quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"       996","corr_author":"1","external_id":{"arxiv":["2508.08558"]},"has_accepted_license":"1","OA_place":"publisher","date_updated":"2026-05-04T09:54:18Z","publication":"The Astrophysical Journal Letters","volume":996,"citation":{"chicago":"Bartos, Imre, and Zoltán Haiman. “Accretion Is All You Need: Black Hole Spin Alignment in Merger GW231123 Indicates Accretion Pathway.” <i>The Astrophysical Journal Letters</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/2041-8213/ae2bff\">https://doi.org/10.3847/2041-8213/ae2bff</a>.","ama":"Bartos I, Haiman Z. Accretion is all you need: Black Hole spin alignment in merger GW231123 indicates accretion pathway. <i>The Astrophysical Journal Letters</i>. 2026;996(2). doi:<a href=\"https://doi.org/10.3847/2041-8213/ae2bff\">10.3847/2041-8213/ae2bff</a>","mla":"Bartos, Imre, and Zoltán Haiman. “Accretion Is All You Need: Black Hole Spin Alignment in Merger GW231123 Indicates Accretion Pathway.” <i>The Astrophysical Journal Letters</i>, vol. 996, no. 2, L44, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/2041-8213/ae2bff\">10.3847/2041-8213/ae2bff</a>.","apa":"Bartos, I., &#38; Haiman, Z. (2026). Accretion is all you need: Black Hole spin alignment in merger GW231123 indicates accretion pathway. <i>The Astrophysical Journal Letters</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/2041-8213/ae2bff\">https://doi.org/10.3847/2041-8213/ae2bff</a>","ista":"Bartos I, Haiman Z. 2026. Accretion is all you need: Black Hole spin alignment in merger GW231123 indicates accretion pathway. The Astrophysical Journal Letters. 996(2), L44.","ieee":"I. Bartos and Z. Haiman, “Accretion is all you need: Black Hole spin alignment in merger GW231123 indicates accretion pathway,” <i>The Astrophysical Journal Letters</i>, vol. 996, no. 2. IOP Publishing, 2026.","short":"I. Bartos, Z. Haiman, The Astrophysical Journal Letters 996 (2026)."},"DOAJ_listed":"1","type":"journal_article","doi":"10.3847/2041-8213/ae2bff","publisher":"IOP Publishing","day":"10"},{"title":"Galaxies in the epoch of reionization are all bark and no bite-plenty of ionizing photons, low escape fractions","year":"2026","_id":"21710","issue":"1","oa_version":"Published Version","month":"03","article_processing_charge":"Yes","OA_type":"gold","acknowledgement":"We wish to thank our colleagues in the CEERS collaboration for their hard work and valuable contributions on this project. We extend our sincerest thanks to the anonymous referee whose critical and constructive report improved the quality of this manuscript. We also thank the JADES team for providing an excellent dataset for science. We with to thank colleagues for valuable discussions, feedback, and suggestions, including John Chisholm, Kevin Huffenberger, Jessica\r\nMeh, Julian Muñoz, Irene Shivaei, Justin Spilker, Aaron Smith, and Romain Teyssier.\r\nPortions of this research were conducted with the advanced computing resources provided by Texas A&M High Performance Research Computing (HPRC, http://hprc.tamu.edu). This work benefited from support from the George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy at Texas A&M University. CP thanks Marsha and Ralph Schilling for generous support of this research. This work was partially support by the Future Investigators in NASA Earth and Space Science and Technology (FINESST) program grant No. 80NSSC23K1487. R.A. acknowledges support of grant PID2023-147386NB-I00 funded by MICIU/AEI/10.13039/501100011033 and by ERDF/EU, and the Severo Ochoa grant CEX2021-001131-S funded by MCIN/AEI/10.13039/50110001103. A.C.C. acknowledges support from a UKRI Frontier Research Guarantee Grant (PI Carnall; grant reference EP/Y037065/1) This work acknowledges support from the NASA/ESA/CSA James Webb Space Telescope through the\r\nSpace Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-03127. Support for program JWST-ERS-01345.009-A, JWST-GO-02079.013-A, JWST-GO-06368.011-A, and JWST-GO-01837.030-A, was provided by NASA through a grant from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127. This work made use of v2.2 of the Binary Population\r\nand Spectral Synthesis (BPASS) models as described in E. R. Stanway & J. J. Eldridge (2018).","arxiv":1,"ddc":["520"],"abstract":[{"lang":"eng","text":"Early results from JWST suggest that Epoch of Reionization (EoR) galaxies produce copious ionizing photons, which, if they escape efficiently, could cause reionization to occur too early. We study this problem using JWST imaging and prism spectroscopy for 412 galaxies at 4.5 < z < 9.0. We fit these data simultaneously with stellar population and nebular emission models that include a parameter for the fraction of ionizing photons that escape the galaxy, fesc. We find that the ionization production efficiency, ξion = Q(H0)/LUV, increases with redshift and decreasing UV luminosity, but shows significant scatter, (log ion z, MUV) 0.3 dex. The inferred escape fractions averaged over the population are low, ranging from〈fesc〉 ≃ 2.6% ± 1.4% at 6 < z < 9 to 6.5% ± 2.2% at 4.5 < z < 6, with weak or no indication of evolution with redshift. This implies that in our models most of the ionizing photons need to be absorbed to account for the nebular emission. We compute the impact of our results on reionization, including the distributions for ξion and fesc, and the evolution and uncertainty of the UV luminosity function. Considering galaxies brighter than MUV < −16 mag would produce an intergalactic medium hydrogen-ionized fraction of xe = 0.5 at 5.3 < z < 5.8, possibly too late compared to constraints from from quasistellar\r\nobject (QSO) sight lines. Including fainter galaxies, MUV < −14 mag, we obtain xe = 0.5 at 6.0 < z < 8.1, fully consistent with QSO and cosmic microwave background data. This implies that EoR galaxies produce plenty of ionizing photons, but that these do not efficiently escape. This may be a result of high gas column densities combined with burstier star formation histories, which limit the time massive stars are able to clear channels through the gas for ionizing photons to escape."}],"scopus_import":"1","date_published":"2026-03-20T00:00:00Z","status":"public","file":[{"date_updated":"2026-05-04T10:40:07Z","file_name":"2026_AstrophysicalJour_Papovich.pdf","success":1,"checksum":"0031a6f197a3fa8c2845de10b6bdc696","file_id":"21791","file_size":6670398,"relation":"main_file","content_type":"application/pdf","access_level":"open_access","date_created":"2026-05-04T10:40:07Z","creator":"dernst"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"publication_status":"published","article_type":"original","author":[{"last_name":"Papovich","full_name":"Papovich, Casey","first_name":"Casey"},{"full_name":"Cole, Justin W.","first_name":"Justin W.","last_name":"Cole"},{"full_name":"Hu, Weida","first_name":"Weida","last_name":"Hu"},{"full_name":"Finkelstein, Steven L.","first_name":"Steven L.","last_name":"Finkelstein"},{"full_name":"Shen, Lu","first_name":"Lu","last_name":"Shen"},{"last_name":"Arrabal Haro","full_name":"Arrabal Haro, Pablo","first_name":"Pablo"},{"last_name":"Amorín","full_name":"Amorín, Ricardo O.","first_name":"Ricardo O."},{"last_name":"Backhaus","full_name":"Backhaus, Bren E.","first_name":"Bren E."},{"last_name":"Bagley","first_name":"Micaela B.","full_name":"Bagley, Micaela B."},{"last_name":"Bhatawdekar","first_name":"Rachana","full_name":"Bhatawdekar, Rachana"},{"last_name":"Calabrò","first_name":"Antonello","full_name":"Calabrò, Antonello"},{"last_name":"Carnall","first_name":"Adam C.","full_name":"Carnall, Adam C."},{"full_name":"Cleri, Nikko J.","first_name":"Nikko J.","last_name":"Cleri"},{"full_name":"Daddi, Emanuele","first_name":"Emanuele","last_name":"Daddi"},{"full_name":"Dickinson, Mark","first_name":"Mark","last_name":"Dickinson"},{"first_name":"Norman A.","full_name":"Grogin, Norman A.","last_name":"Grogin"},{"last_name":"Holwerda","full_name":"Holwerda, Benne W.","first_name":"Benne W."},{"last_name":"Jaskot","first_name":"Anne E.","full_name":"Jaskot, Anne E."},{"last_name":"Koekemoer","full_name":"Koekemoer, Anton M.","first_name":"Anton M."},{"full_name":"Llerena, Mario","first_name":"Mario","last_name":"Llerena"},{"last_name":"Lucas","full_name":"Lucas, Ray A.","first_name":"Ray A."},{"last_name":"Mascia","first_name":"Sara","full_name":"Mascia, Sara","id":"edaf889c-c7cd-11ef-ab1b-bb28c431bd29"},{"last_name":"Pacucci","full_name":"Pacucci, Fabio","first_name":"Fabio"},{"last_name":"Pentericci","first_name":"Laura","full_name":"Pentericci, Laura"},{"first_name":"Pablo G.","full_name":"Pérez-González, Pablo G.","last_name":"Pérez-González"},{"first_name":"Nor","full_name":"Pirzkal, Nor","last_name":"Pirzkal"},{"first_name":"Srinivasan","full_name":"Raghunathan, Srinivasan","last_name":"Raghunathan"},{"first_name":"Lise Marie","full_name":"Seillé, Lise Marie","last_name":"Seillé"},{"last_name":"Somerville","full_name":"Somerville, Rachel S.","first_name":"Rachel S."},{"full_name":"Yung, L. Y.Aaron","first_name":"L. Y.Aaron","last_name":"Yung"}],"doi":"10.3847/1538-4357/ae3b25","day":"20","publisher":"IOP Publishing","type":"journal_article","citation":{"chicago":"Papovich, Casey, Justin W. Cole, Weida Hu, Steven L. Finkelstein, Lu Shen, Pablo Arrabal Haro, Ricardo O. Amorín, et al. “Galaxies in the Epoch of Reionization Are All Bark and No Bite-Plenty of Ionizing Photons, Low Escape Fractions.” <i>The Astrophysical Journal</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/1538-4357/ae3b25\">https://doi.org/10.3847/1538-4357/ae3b25</a>.","ama":"Papovich C, Cole JW, Hu W, et al. Galaxies in the epoch of reionization are all bark and no bite-plenty of ionizing photons, low escape fractions. <i>The Astrophysical Journal</i>. 2026;1000(1). doi:<a href=\"https://doi.org/10.3847/1538-4357/ae3b25\">10.3847/1538-4357/ae3b25</a>","ieee":"C. Papovich <i>et al.</i>, “Galaxies in the epoch of reionization are all bark and no bite-plenty of ionizing photons, low escape fractions,” <i>The Astrophysical Journal</i>, vol. 1000, no. 1. IOP Publishing, 2026.","apa":"Papovich, C., Cole, J. W., Hu, W., Finkelstein, S. L., Shen, L., Arrabal Haro, P., … Yung, L. Y. A. (2026). Galaxies in the epoch of reionization are all bark and no bite-plenty of ionizing photons, low escape fractions. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ae3b25\">https://doi.org/10.3847/1538-4357/ae3b25</a>","mla":"Papovich, Casey, et al. “Galaxies in the Epoch of Reionization Are All Bark and No Bite-Plenty of Ionizing Photons, Low Escape Fractions.” <i>The Astrophysical Journal</i>, vol. 1000, no. 1, 111, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/1538-4357/ae3b25\">10.3847/1538-4357/ae3b25</a>.","ista":"Papovich C, Cole JW, Hu W, Finkelstein SL, Shen L, Arrabal Haro P, Amorín RO, Backhaus BE, Bagley MB, Bhatawdekar R, Calabrò A, Carnall AC, Cleri NJ, Daddi E, Dickinson M, Grogin NA, Holwerda BW, Jaskot AE, Koekemoer AM, Llerena M, Lucas RA, Mascia S, Pacucci F, Pentericci L, Pérez-González PG, Pirzkal N, Raghunathan S, Seillé LM, Somerville RS, Yung LYA. 2026. Galaxies in the epoch of reionization are all bark and no bite-plenty of ionizing photons, low escape fractions. The Astrophysical Journal. 1000(1), 111.","short":"C. Papovich, J.W. Cole, W. Hu, S.L. Finkelstein, L. Shen, P. Arrabal Haro, R.O. Amorín, B.E. Backhaus, M.B. Bagley, R. Bhatawdekar, A. Calabrò, A.C. Carnall, N.J. Cleri, E. Daddi, M. Dickinson, N.A. Grogin, B.W. Holwerda, A.E. Jaskot, A.M. Koekemoer, M. Llerena, R.A. Lucas, S. Mascia, F. Pacucci, L. Pentericci, P.G. Pérez-González, N. Pirzkal, S. Raghunathan, L.M. Seillé, R.S. Somerville, L.Y.A. Yung, The Astrophysical Journal 1000 (2026)."},"volume":1000,"publication":"The Astrophysical Journal","date_updated":"2026-05-04T10:44:57Z","has_accepted_license":"1","OA_place":"publisher","external_id":{"arxiv":["2505.08870"]},"intvolume":"      1000","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2026-04-12T22:01:49Z","file_date_updated":"2026-05-04T10:40:07Z","article_number":"111","department":[{"_id":"JoMa"}]},{"project":[{"grant_number":"101076224","_id":"bd9b2118-d553-11ed-ba76-db24564edfea","name":"Young galaxies as tracers and agents of cosmic reionization"}],"publication_status":"published","article_type":"original","author":[{"first_name":"Jenny E.","full_name":"Greene, Jenny E.","last_name":"Greene"},{"last_name":"Setton","full_name":"Setton, David J.","first_name":"David J."},{"full_name":"Furtak, Lukas J.","first_name":"Lukas J.","last_name":"Furtak"},{"last_name":"Naidu","first_name":"Rohan P.","full_name":"Naidu, Rohan P."},{"first_name":"Marta","full_name":"Volonteri, Marta","last_name":"Volonteri"},{"full_name":"Dayal, Pratika","first_name":"Pratika","last_name":"Dayal"},{"last_name":"Labbe","full_name":"Labbe, Ivo","first_name":"Ivo"},{"last_name":"Van Dokkum","first_name":"Pieter","full_name":"Van Dokkum, Pieter"},{"full_name":"Bezanson, Rachel","first_name":"Rachel","last_name":"Bezanson"},{"last_name":"Brammer","first_name":"Gabriel","full_name":"Brammer, Gabriel"},{"full_name":"Cutler, Sam E.","first_name":"Sam E.","last_name":"Cutler"},{"first_name":"Karl","full_name":"Glazebrook, Karl","last_name":"Glazebrook"},{"full_name":"De Graaff, Anna","first_name":"Anna","last_name":"De Graaff"},{"first_name":"Michaela","full_name":"Hirschmann, Michaela","last_name":"Hirschmann"},{"last_name":"Hviding","first_name":"Raphael E.","full_name":"Hviding, Raphael E."},{"last_name":"Kokorev","full_name":"Kokorev, Vasily","first_name":"Vasily"},{"first_name":"Joel","full_name":"Leja, Joel","last_name":"Leja"},{"full_name":"Liu, Hanpu","first_name":"Hanpu","last_name":"Liu"},{"full_name":"Ma, Yilun","first_name":"Yilun","last_name":"Ma"},{"last_name":"Matthee","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"full_name":"Nanayakkara, Themiya","first_name":"Themiya","last_name":"Nanayakkara"},{"last_name":"Oesch","full_name":"Oesch, Pascal A.","first_name":"Pascal A."},{"first_name":"Richard","full_name":"Pan, Richard","last_name":"Pan"},{"last_name":"Price","first_name":"Sedona H.","full_name":"Price, Sedona H."},{"first_name":"Justin S.","full_name":"Spilker, Justin S.","last_name":"Spilker"},{"first_name":"Bingjie","full_name":"Wang, Bingjie","last_name":"Wang"},{"first_name":"John R.","full_name":"Weaver, John R.","last_name":"Weaver"},{"last_name":"Whitaker","full_name":"Whitaker, Katherine E.","first_name":"Katherine E."},{"first_name":"Christina C.","full_name":"Williams, Christina C.","last_name":"Williams"},{"full_name":"Zitrin, Adi","first_name":"Adi","last_name":"Zitrin"}],"file":[{"success":1,"checksum":"7b3cb025d4bcaa35c6e52bd0c8fb6cf4","file_name":"2026_AstrophysicalJour_Greene.pdf","date_updated":"2026-05-04T11:19:48Z","content_type":"application/pdf","date_created":"2026-05-04T11:19:48Z","creator":"dernst","access_level":"open_access","file_id":"21792","file_size":684400,"relation":"main_file"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"abstract":[{"text":"New populations of red active galactic nuclei (known as “little red dots”) discovered by JWST exhibit remarkable spectral energy distributions. Leveraging X-ray through far-infrared observations of two of the most luminous known little red dots, we directly measure their bolometric luminosities. We find evidence that more than half of the bolometric luminosity likely emerges in the rest-frame optical, with Lbol/L5100 = 5, roughly half the value for “standard” active galactic nuclei. Meanwhile, the X-ray emitting corona, UV-emitting blackbody, and reprocessed mid to far-infrared emission are all considerably subdominant, assuming that the far-infrared luminosity is well below current measured limits. We present new bolometric corrections that dramatically lower inferred bolometric luminosities by a factor of 10 compared to published values in the literature. These bolometric corrections are in accord with expectations from models in which gas absorption and reprocessing are responsible for the red rest-frame optical colors of little red dots. We discuss how this lowered luminosity scale suggests a lower mass scale for the population by at least an order of magnitude (e.g., ∼105–107 M⊙ black holes, and ∼108 M⊙ galaxies), alleviating tensions with clustering, overmassive black holes, and the integrated black hole mass density in the Universe.","lang":"eng"}],"scopus_import":"1","date_published":"2026-01-10T00:00:00Z","status":"public","OA_type":"gold","acknowledgement":"We benefit from the following JWST programs: UNCOVER (JWST/GO #2561; Labbé & Bezanson); ALT (JWST-GO #3516; Naidu & Matthee); MegaScience (JWST-GO #4111; Suess); RUBIES (JWST-GO #4233; de Graaff & Brammer); PRIMER (JWST/GO #1837; Dunlop).\r\n\r\nWe acknowledge funding from NSF/AAG #2306950, JWST-GO-02561, JWST-GO-03516, and JWST-GO-04111, provided through a grant from the STScI under NASA contract NAS5-03127. I.L. acknowledges support from Australian Research Council Future Fellowship FT220100798. K.G. and T.N. acknowledge support from Australian Research Council Laureate Fellowship FL180100060. A.Z. acknowledges support by grant No. 2020750 from the United States-Israel Binational Science Foundation (BSF) and grant No. 2109066 from the United States National Science Foundation (NSF); by the Ministry of Science & Technology, Israel; and by the Israel Science Foundation grant No. 864/23. J.M. and I.K. are funded by the European Union (ERC, AGENTS, 101076224). Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. Y.F. acknowledges support from JSPS KAKENHI grant No. JSPS KAKENHI grant Nos. JP22K21349 and JP23K13149. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract No. MB22.00072, as well as from the Swiss National Science Foundation (SNSF) through project grant 200020_207349. The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant DNRF140. Support for this work for RPN was provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. The work of CCW is supported by NOIRLab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. J.M. acknowledges funding by the European Union (ERC, AGENTS, 101076224). R.E.H. acknowledges support by the German Aerospace Center (DLR) and the Federal Ministry for Economic Affairs and Energy (BMWi) through program 50OR2403 “RUBIES.”","arxiv":1,"ddc":["520"],"article_processing_charge":"Yes","month":"01","year":"2026","issue":"2","_id":"21715","oa_version":"Published Version","title":"What you see is what you get: Empirically measured bolometric luminosities of Little Red Dots","file_date_updated":"2026-05-04T11:19:48Z","date_created":"2026-04-12T22:01:50Z","article_number":"129","PlanS_conform":"1","department":[{"_id":"JoMa"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"intvolume":"       996","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"date_updated":"2026-05-04T11:20:42Z","OA_place":"publisher","has_accepted_license":"1","external_id":{"arxiv":["2509.05434"]},"publication":"The Astrophysical Journal","DOAJ_listed":"1","citation":{"short":"J.E. Greene, D.J. Setton, L.J. Furtak, R.P. Naidu, M. Volonteri, P. Dayal, I. Labbe, P. Van Dokkum, R. Bezanson, G. Brammer, S.E. Cutler, K. Glazebrook, A. De Graaff, M. Hirschmann, R.E. Hviding, V. Kokorev, J. Leja, H. Liu, Y. Ma, J.J. Matthee, T. Nanayakkara, P.A. Oesch, R. Pan, S.H. Price, J.S. Spilker, B. Wang, J.R. Weaver, K.E. Whitaker, C.C. Williams, A. Zitrin, The Astrophysical Journal 996 (2026).","mla":"Greene, Jenny E., et al. “What You See Is What You Get: Empirically Measured Bolometric Luminosities of Little Red Dots.” <i>The Astrophysical Journal</i>, vol. 996, no. 2, 129, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/1538-4357/ae1836\">10.3847/1538-4357/ae1836</a>.","apa":"Greene, J. E., Setton, D. J., Furtak, L. J., Naidu, R. P., Volonteri, M., Dayal, P., … Zitrin, A. (2026). What you see is what you get: Empirically measured bolometric luminosities of Little Red Dots. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ae1836\">https://doi.org/10.3847/1538-4357/ae1836</a>","ista":"Greene JE, Setton DJ, Furtak LJ, Naidu RP, Volonteri M, Dayal P, Labbe I, Van Dokkum P, Bezanson R, Brammer G, Cutler SE, Glazebrook K, De Graaff A, Hirschmann M, Hviding RE, Kokorev V, Leja J, Liu H, Ma Y, Matthee JJ, Nanayakkara T, Oesch PA, Pan R, Price SH, Spilker JS, Wang B, Weaver JR, Whitaker KE, Williams CC, Zitrin A. 2026. What you see is what you get: Empirically measured bolometric luminosities of Little Red Dots. The Astrophysical Journal. 996(2), 129.","ieee":"J. E. Greene <i>et al.</i>, “What you see is what you get: Empirically measured bolometric luminosities of Little Red Dots,” <i>The Astrophysical Journal</i>, vol. 996, no. 2. IOP Publishing, 2026.","ama":"Greene JE, Setton DJ, Furtak LJ, et al. What you see is what you get: Empirically measured bolometric luminosities of Little Red Dots. <i>The Astrophysical Journal</i>. 2026;996(2). doi:<a href=\"https://doi.org/10.3847/1538-4357/ae1836\">10.3847/1538-4357/ae1836</a>","chicago":"Greene, Jenny E., David J. Setton, Lukas J. Furtak, Rohan P. Naidu, Marta Volonteri, Pratika Dayal, Ivo Labbe, et al. “What You See Is What You Get: Empirically Measured Bolometric Luminosities of Little Red Dots.” <i>The Astrophysical Journal</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/1538-4357/ae1836\">https://doi.org/10.3847/1538-4357/ae1836</a>."},"volume":996,"publisher":"IOP Publishing","doi":"10.3847/1538-4357/ae1836","day":"10","type":"journal_article"},{"issue":"6","_id":"21716","year":"2026","oa_version":"Published Version","title":"Genetic and epigenetic mechanisms underlying male reproductive thermotolerance","article_processing_charge":"Yes (via OA deal)","month":"04","scopus_import":"1","abstract":[{"text":"Male germline development in plants is highly sensitive to heat stress, with elevated temperatures frequently impairing male fertility and consequently reducing seed production. Indeed, recent global warming has decreased major crop yields, emphasizing the urgent need to elucidate the molecular and cellular mechanisms underlying heat-induced male sterility. This review synthesizes current knowledge on how heat stress disrupts microsporogenesis and microgametogenesis, and how plants counteract these stresses through diverse thermotolerance mechanisms. We emphasize temperature-sensitive processes, including meiotic progression in male germ cells, programmed cell death of somatic tapetal nurse cells, and post-meiotic pollen tube development. We further discuss how epigenetic regulators enhance thermotolerance by reprogramming DNA methylation landscapes and modulating histone variant distribution. Finally, we propose future directions aimed at understanding the mechanisms of reproductive thermotolerance from the epigenetic perspective.","lang":"eng"}],"date_published":"2026-04-01T00:00:00Z","status":"public","OA_type":"hybrid","ddc":["580"],"acknowledgement":"This work was supported by JSPS KAKENHI (grant number JP22J01430) and the Osamu Hayaishi Memorial Scholarship for Study Abroad for H.N.","article_type":"original","publication_status":"epub_ahead","author":[{"first_name":"Hiroki","full_name":"Nagai, Hiroki","id":"608df3e6-e2ab-11ed-8890-c9318cec7da4","last_name":"Nagai","orcid":"0000-0003-1671-9434"},{"last_name":"Feng","orcid":"0000-0002-4008-1234","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","full_name":"Feng, Xiaoqi","first_name":"Xiaoqi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"citation":{"apa":"NAGAI, H., &#38; Feng, X. (2026). Genetic and epigenetic mechanisms underlying male reproductive thermotolerance. <i>Current Opinion in Plant Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.pbi.2026.102881\">https://doi.org/10.1016/j.pbi.2026.102881</a>","mla":"NAGAI, HIROKI, and Xiaoqi Feng. “Genetic and Epigenetic Mechanisms Underlying Male Reproductive Thermotolerance.” <i>Current Opinion in Plant Biology</i>, vol. 91, no. 6, 102881, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.pbi.2026.102881\">10.1016/j.pbi.2026.102881</a>.","ista":"NAGAI H, Feng X. 2026. Genetic and epigenetic mechanisms underlying male reproductive thermotolerance. Current Opinion in Plant Biology. 91(6), 102881.","ieee":"H. NAGAI and X. Feng, “Genetic and epigenetic mechanisms underlying male reproductive thermotolerance,” <i>Current Opinion in Plant Biology</i>, vol. 91, no. 6. Elsevier, 2026.","short":"H. NAGAI, X. Feng, Current Opinion in Plant Biology 91 (2026).","chicago":"NAGAI, HIROKI, and Xiaoqi Feng. “Genetic and Epigenetic Mechanisms Underlying Male Reproductive Thermotolerance.” <i>Current Opinion in Plant Biology</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.pbi.2026.102881\">https://doi.org/10.1016/j.pbi.2026.102881</a>.","ama":"NAGAI H, Feng X. Genetic and epigenetic mechanisms underlying male reproductive thermotolerance. <i>Current Opinion in Plant Biology</i>. 2026;91(6). doi:<a href=\"https://doi.org/10.1016/j.pbi.2026.102881\">10.1016/j.pbi.2026.102881</a>"},"volume":91,"day":"01","doi":"10.1016/j.pbi.2026.102881","publisher":"Elsevier","type":"journal_article","publication":"Current Opinion in Plant Biology","main_file_link":[{"url":"https://doi.org/10.1016/j.pbi.2026.102881","open_access":"1"}],"language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"        91","publication_identifier":{"eissn":["1879-0356"],"issn":["1369-5266"]},"has_accepted_license":"1","OA_place":"publisher","date_updated":"2026-05-04T11:15:57Z","corr_author":"1","date_created":"2026-04-12T22:01:50Z","PlanS_conform":"1","department":[{"_id":"XiFe"}],"article_number":"102881","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"}}]