[{"OA_type":"green","doi":"10.48550/arXiv.2403.06833","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2024","publication_status":"submitted","OA_place":"repository","citation":{"short":"E. Zverev, S. Abdelnabi, S. Tabesh, M. Fritz, C. Lampert, ArXiv (n.d.).","ieee":"E. Zverev, S. Abdelnabi, S. Tabesh, M. Fritz, and C. Lampert, “Can LLMs separate instructions from data? And what do we even mean by that?,” <i>arXiv</i>. .","chicago":"Zverev, Egor, Sahar Abdelnabi, Soroush Tabesh, Mario Fritz, and Christoph Lampert. “Can LLMs Separate Instructions from Data? And What Do We Even Mean by That?” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2403.06833\">https://doi.org/10.48550/arXiv.2403.06833</a>.","apa":"Zverev, E., Abdelnabi, S., Tabesh, S., Fritz, M., &#38; Lampert, C. (n.d.). Can LLMs separate instructions from data? And what do we even mean by that? <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2403.06833\">https://doi.org/10.48550/arXiv.2403.06833</a>","ama":"Zverev E, Abdelnabi S, Tabesh S, Fritz M, Lampert C. Can LLMs separate instructions from data? And what do we even mean by that? <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2403.06833\">10.48550/arXiv.2403.06833</a>","mla":"Zverev, Egor, et al. “Can LLMs Separate Instructions from Data? And What Do We Even Mean by That?” <i>ArXiv</i>, 2403.06833, doi:<a href=\"https://doi.org/10.48550/arXiv.2403.06833\">10.48550/arXiv.2403.06833</a>.","ista":"Zverev E, Abdelnabi S, Tabesh S, Fritz M, Lampert C. Can LLMs separate instructions from data? And what do we even mean by that? arXiv, 2403.06833."},"title":"Can LLMs separate instructions from data? And what do we even mean by that?","abstract":[{"text":"Instruction-tuned Large Language Models (LLMs) show impressive results in numerous practical applications, but they lack essential safety features that are common in other areas of computer science, particularly an explicit separation of instructions and data. This makes them vulnerable to manipulations such as indirect prompt injections and generally unsuitable for safety-critical tasks. Surprisingly, there is currently no established definition or benchmark to quantify this phenomenon. In this work, we close this gap by introducing a formal measure for instruction-data separation and an empirical variant that is calculable from a model's outputs. We also present a new dataset, SEP, that allows estimating the measure for real-world models. Our results on various LLMs show that the problem of instruction-data separation is real: all models fail to achieve high separation, and canonical mitigation techniques, such as prompt engineering and fine-tuning, either fail to substantially improve separation or reduce model utility. The source code and SEP dataset are openly accessible at https://github.com/egozverev/Shold-It-Be-Executed-Or-Processed.\r\n","lang":"eng"}],"acknowledgement":"The authors would like to sincerely thank Juan Rocamonde for valuable feedback to our manuscript. We acknowledge the support from the Scientific Service Units (SSU) of ISTA through resources provided by Scientific Computing (SciComp). We thank Dan Alistarh for providing us with computational resources. This work was partially funded by the German Federal Ministry of Education and Research (BMBF) under the grant AIgenCY (16KIS2012) and ELSA – European Lighthouse on Secure and Safe AI funded by the European Union under grant agreement No. 101070617. Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or European Commission. Neither the European Union nor the European Commission can be held responsible for them.","status":"public","month":"03","_id":"19063","department":[{"_id":"GradSch"},{"_id":"ChLa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2025-02-20T10:13:42Z","oa":1,"date_updated":"2026-08-13T07:26:54Z","file":[{"relation":"main_file","checksum":"35eb43968684b87be59144603ef10af0","file_size":530972,"date_created":"2025-02-20T10:11:45Z","content_type":"application/pdf","access_level":"open_access","success":1,"file_id":"19064","date_updated":"2025-02-20T10:11:45Z","creator":"ezverev","file_name":"2403.06833v3.pdf"}],"related_material":{"link":[{"relation":"software","url":" https://github.com/egozverev/Shold-It-Be-Executed-Or-Processed"}]},"file_date_updated":"2025-02-20T10:11:45Z","oa_version":"Preprint","publication":"arXiv","author":[{"last_name":"Zverev","full_name":"Zverev, Egor","id":"05162b19-1340-11ed-8f02-fa94e0e8c3bc","first_name":"Egor"},{"first_name":"Sahar","full_name":"Abdelnabi, Sahar","last_name":"Abdelnabi"},{"orcid":"0009-0003-4119-6281","last_name":"Tabesh","full_name":"Tabesh, Soroush","first_name":"Soroush","id":"06000900-6068-11ef-8d61-c2472ef2e752"},{"full_name":"Fritz, Mario","first_name":"Mario","last_name":"Fritz"},{"full_name":"Lampert, Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph","orcid":"0000-0001-8622-7887","last_name":"Lampert"}],"article_number":"2403.06833","corr_author":"1","article_processing_charge":"No","acknowledged_ssus":[{"_id":"ScienComp"}],"type":"preprint","day":"01","fulldoi":"https://doi.org/10.48550/arXiv.2403.06833","ddc":["000"],"has_accepted_license":"1","language":[{"iso":"eng"}],"arxiv":1,"date_published":"2024-03-01T00:00:00Z","external_id":{"arxiv":["2403.06833"]}},{"page":"69-86","author":[{"full_name":"Aebischer, Kathrin","first_name":"Kathrin","last_name":"Aebischer"},{"last_name":"Becker","orcid":"0000-0002-6401-5151","full_name":"Becker, Lea Marie","first_name":"Lea Marie","id":"36336939-eb97-11eb-a6c2-c83f1214ca79"},{"orcid":"0000-0002-9350-7606","last_name":"Schanda","full_name":"Schanda, Paul","first_name":"Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425"},{"first_name":"Matthias","full_name":"Ernst, Matthias","last_name":"Ernst"}],"publication_identifier":{"eissn":["2699-0016"]},"scopus_import":"1","day":"11","article_processing_charge":"Yes","type":"journal_article","ddc":["530"],"fulldoi":"https://doi.org/10.5194/mr-5-69-2024","has_accepted_license":"1","pmid":1,"external_id":{"pmid":["40384772"]},"date_published":"2024-06-11T00:00:00Z","language":[{"iso":"eng"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":5,"year":"2024","publication_status":"published","citation":{"chicago":"Aebischer, Kathrin, Lea Marie Becker, Paul Schanda, and Matthias Ernst. “Evaluating the Motional Timescales Contributing to Averaged Anisotropic Interactions in MAS Solid-State NMR.” <i>Magnetic Resonance</i>. Copernicus Publications, 2024. <a href=\"https://doi.org/10.5194/mr-5-69-2024\">https://doi.org/10.5194/mr-5-69-2024</a>.","apa":"Aebischer, K., Becker, L. M., Schanda, P., &#38; Ernst, M. (2024). Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR. <i>Magnetic Resonance</i>. Copernicus Publications. <a href=\"https://doi.org/10.5194/mr-5-69-2024\">https://doi.org/10.5194/mr-5-69-2024</a>","short":"K. Aebischer, L.M. Becker, P. Schanda, M. Ernst, Magnetic Resonance 5 (2024) 69–86.","ieee":"K. Aebischer, L. M. Becker, P. Schanda, and M. Ernst, “Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR,” <i>Magnetic Resonance</i>, vol. 5, no. 1. Copernicus Publications, pp. 69–86, 2024.","ista":"Aebischer K, Becker LM, Schanda P, Ernst M. 2024. Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR. Magnetic Resonance. 5(1), 69–86.","ama":"Aebischer K, Becker LM, Schanda P, Ernst M. Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR. <i>Magnetic Resonance</i>. 2024;5(1):69-86. doi:<a href=\"https://doi.org/10.5194/mr-5-69-2024\">10.5194/mr-5-69-2024</a>","mla":"Aebischer, Kathrin, et al. “Evaluating the Motional Timescales Contributing to Averaged Anisotropic Interactions in MAS Solid-State NMR.” <i>Magnetic Resonance</i>, vol. 5, no. 1, Copernicus Publications, 2024, pp. 69–86, doi:<a href=\"https://doi.org/10.5194/mr-5-69-2024\">10.5194/mr-5-69-2024</a>."},"doi":"10.5194/mr-5-69-2024","status":"public","issue":"1","project":[{"name":"Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches","_id":"7be609c4-9f16-11ee-852c-85015ce2b9b0","grant_number":"26777"}],"publisher":"Copernicus Publications","quality_controlled":"1","abstract":[{"lang":"eng","text":"Dynamic processes in molecules can occur on a wide range of timescales, and it is important to understand which timescales of motion contribute to different parameters used in dynamics measurements. For spin relaxation, this can easily be understood from the sampling frequencies of the spectral-density function by different relaxation-rate constants. In addition to data from relaxation measurements, determining dynamically averaged anisotropic interactions in magic-angle spinning (MAS) solid-state NMR allows for better quantification of the amplitude of molecular motion. For partially averaged anisotropic interactions, the relevant timescales of motion are not so clearly defined. Whether the averaging depends on the experimental methods (e.g., pulse sequences) or conditions (e.g., MAS frequency, magnitude of anisotropic interaction, radio-frequency field amplitudes) is not fully understood. To investigate these questions, we performed numerical simulations of dynamic systems based on the stochastic Liouville equation using several experiments for recoupling the dipolar coupling, chemical-shift anisotropy or quadrupolar coupling. As described in the literature, the transition between slow motion, where parameters characterizing the anisotropic interaction are not averaged, and fast motion, where the tensors are averaged leading to a scaled anisotropic quantity, occurs over a window of motional rate constants that depends mainly on the strength of the interaction. This transition region can span 2 orders of magnitude in exchange-rate constants (typically in the microsecond range) but depends only marginally on the employed recoupling scheme or sample spinning frequency. The transition region often coincides with a fast relaxation of coherences, making precise quantitative measurements difficult. Residual couplings in off-magic-angle experiments, however, average over longer timescales of motion. While in principle one may gain information on the timescales of motion from the transition area, extracting such information is hampered by low signal-to-noise ratio in experimental spectra due to fast relaxation that occurs in the same region."}],"title":"Evaluating the motional timescales contributing to averaged anisotropic interactions in MAS solid-state NMR","acknowledgement":"We would like to thank Kay Saalwächter for pointing out important aspects of the intermediate regime during the open review process. Lea Marie Becker is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria.\r\nThis research has been supported by the Österreichischen Akademie der Wissenschaften (grant no. PR10660EAW01) and the Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (grant nos. 200020_188988 and 200020_219375).","department":[{"_id":"PaSc"}],"article_type":"original","date_created":"2024-06-23T22:01:02Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"06","_id":"17161","file_date_updated":"2024-06-27T06:42:55Z","intvolume":"         5","publication":"Magnetic Resonance","oa_version":"Published Version","date_updated":"2026-09-11T08:49:55Z","file":[{"relation":"main_file","file_size":6736194,"checksum":"d01074f6919387fcaf8c9ebed320ccae","date_created":"2024-06-27T06:42:55Z","content_type":"application/pdf","access_level":"open_access","success":1,"file_id":"17181","date_updated":"2024-06-27T06:42:55Z","creator":"dernst","file_name":"2024_MagneticResonance_Aebischer.pdf"}],"oa":1,"related_material":{"record":[{"id":"22906","status":"public","relation":"research_data"}]}},{"status":"public","day":"03","publisher":"Repository","title":"Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR","article_processing_charge":"No","type":"research_data_reference","contributor":[{"first_name":"Matthias","contributor_type":"contact_person","last_name":"Ernst"},{"last_name":"Aebischer","first_name":"Kathrin","contributor_type":"data_collector"},{"contributor_type":"data_collector","first_name":"Matthias","last_name":"Ernst"},{"last_name":"Schanda","first_name":"Paul","contributor_type":"data_collector"},{"last_name":"Becker","contributor_type":"data_collector","first_name":"Lea Marie"},{"first_name":"Matthias","contributor_type":"producer","last_name":" Ernst"},{"last_name":" Aebischer","contributor_type":"producer","first_name":"Kathrin"},{"last_name":"Schanda","first_name":"Paul ","contributor_type":"producer"},{"last_name":"Becker","contributor_type":"producer","first_name":"Lea Marie"}],"year":"2024","citation":{"ista":"Aebischer K. 2024. Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR, Repository, <a href=\"https://doi.org/10.3929/ethz-b-000666765\">10.3929/ethz-b-000666765</a>.","ama":"Aebischer K. Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR. 2024. doi:<a href=\"https://doi.org/10.3929/ethz-b-000666765\">10.3929/ethz-b-000666765</a>","mla":"Aebischer, Kathrin. <i>Evaluating the Motional Time Scales Contributing to Averaged Anisotropic Interactions in MAS Solid-State NMR</i>. Repository, 2024, doi:<a href=\"https://doi.org/10.3929/ethz-b-000666765\">10.3929/ethz-b-000666765</a>.","chicago":"Aebischer, Kathrin. “Evaluating the Motional Time Scales Contributing to Averaged Anisotropic Interactions in MAS Solid-State NMR.” Repository, 2024. <a href=\"https://doi.org/10.3929/ethz-b-000666765\">https://doi.org/10.3929/ethz-b-000666765</a>.","apa":"Aebischer, K. (2024). Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR. Repository. <a href=\"https://doi.org/10.3929/ethz-b-000666765\">https://doi.org/10.3929/ethz-b-000666765</a>","short":"K. Aebischer, (2024).","ieee":"K. Aebischer, “Evaluating the motional time scales contributing to averaged anisotropic interactions in MAS solid-state NMR.” Repository, 2024."},"OA_place":"repository","author":[{"last_name":"Aebischer","first_name":"Kathrin","full_name":"Aebischer, Kathrin"}],"OA_type":"green","main_file_link":[{"url":"https://doi.org/10.3929/ethz-b-000666765","open_access":"1"}],"doi":"10.3929/ethz-b-000666765","oa_version":"None","date_published":"2024-04-03T00:00:00Z","date_updated":"2026-09-11T08:49:55Z","oa":1,"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"17161"}]},"department":[{"_id":"PaSc"}],"date_created":"2026-09-11T08:49:48Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","ddc":["530"],"fulldoi":"https://doi.org/10.3929/ethz-b-000666765","month":"04","_id":"22906"},{"related_material":{"record":[{"relation":"research_data","id":"18296","status":"public"}]},"oa":1,"isi":1,"file":[{"success":1,"file_id":"18608","date_updated":"2024-12-03T08:56:53Z","creator":"dernst","file_name":"2024_PloSBio_Kim.pdf","file_size":3057631,"checksum":"7de2dcb50deb65dde05c80082bb85a82","relation":"main_file","access_level":"open_access","date_created":"2024-12-03T08:56:53Z","content_type":"application/pdf"}],"date_updated":"2026-04-16T12:20:34Z","oa_version":"Published Version","publication":"PLoS Biology","intvolume":"        22","file_date_updated":"2024-12-03T08:56:53Z","DOAJ_listed":"1","_id":"18603","ec_funded":1,"month":"11","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-12-01T23:01:54Z","APC_amount":"6248,82 EUR","article_type":"original","department":[{"_id":"PeJo"},{"_id":"EM-Fac"},{"_id":"RySh"}],"acknowledgement":"We thank Carolina Borges-Merjane, Jing-Jing Chen, Katharina Lichter, and Samuel Young for critically reading the manuscript; the Electron Microscopy Facility of ISTA, in particular Vanessa Zheden, for extensive support, advice, and experimental assistance; the Preclinical Facility of ISTA, in particular Victoria Wimmer and Michael Schunn, for experimental assistance; Florian Marr and Christina Altmutter for technical support; Alois Schlögl for help with analysis; and Eleftheria Kralli-Beller for manuscript editing. We also thank Cordelia Imig for providing Munc13-1cKO-Munc13-2/3(−/−) mutant mice. Part of the work has been published in O.K.’s thesis in partial fulfillment of the requirements for the degree of Doctor of Philosophy.\r\nThis project received funding from the European Research Council and European Union’s Horizon 2020 research and innovation programme (ERC 692692 to P.J.; https://cordis.europa.eu/project/id/692692/de) and from the Fond zur Förderung der Wissenschaftlichen Forschung (Z312-B27 Wittgenstein award to P.J., https://www.fwf.ac.at/en/funding/portfolio/projects/fwf-wittgenstein-award; W1205-B09 and P36232-B to P.J., https://www.fwf.ac.at/en/funding; I6166-B to R.S.; https://www.fwf.ac.at/en/funding). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","title":"Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons","abstract":[{"text":"It is widely believed that information storage in neuronal circuits involves nanoscopic structural changes at synapses, resulting in the formation of synaptic engrams. However, direct evidence for this hypothesis is lacking. To test this conjecture, we combined chemical potentiation, functional analysis by paired pre-postsynaptic recordings, and structural analysis by electron microscopy (EM) and freeze-fracture replica labeling (FRL) at the rodent hippocampal mossy fiber synapse, a key synapse in the trisynaptic circuit of the hippocampus. Biophysical analysis of synaptic transmission revealed that forskolin-induced chemical potentiation increased the readily releasable vesicle pool size and vesicular release probability by 146% and 49%, respectively. Structural analysis of mossy fiber synapses by EM and FRL demonstrated an increase in the number of vesicles close to the plasma membrane and the number of clusters of the priming protein Munc13-1, indicating an increase in the number of both docked and primed vesicles. Furthermore, FRL analysis revealed a significant reduction of the distance between Munc13-1 and CaV2.1 Ca2+ channels, suggesting reconfiguration of the channel-vesicle coupling nanotopography. Our results indicate that presynaptic plasticity is associated with structural reorganization of active zones. We propose that changes in potential nanoscopic organization at synaptic vesicle release sites may be correlates of learning and memory at a plastic central synapse.","lang":"eng"}],"quality_controlled":"1","project":[{"name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","grant_number":"692692","call_identifier":"H2020"},{"name":"Synaptic communication in neuronal microcircuits","grant_number":"Z00312","_id":"25C5A090-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"name":"Mechanisms of GABA release in hippocampal circuits","_id":"bd88be38-d553-11ed-ba76-81d5a70a6ef5","grant_number":"P36232"},{"_id":"b1b85715-d554-11ed-a5ad-84a07fc9f18e","grant_number":"I06166","name":"Structural & functional basis of presynaptic plasticity"},{"grant_number":"W01205","_id":"25C3DBB6-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Zellkommunikation in Gesundheit und Krankheit"},{"name":"FWF Open Access Fund","call_identifier":"FWF","_id":"3AC91DDA-15DF-11EA-824D-93A3E7B544D1"}],"publisher":"Public Library of Science","issue":"11","status":"public","doi":"10.1371/journal.pbio.3002879","OA_type":"gold","OA_place":"publisher","publication_status":"published","citation":{"ieee":"O. Kim, Y. Okamoto, W. Kaufmann, N. Brose, R. Shigemoto, and P. M. Jonas, “Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons,” <i>PLoS Biology</i>, vol. 22, no. 11. Public Library of Science, 2024.","short":"O. Kim, Y. Okamoto, W. Kaufmann, N. Brose, R. Shigemoto, P.M. Jonas, PLoS Biology 22 (2024).","apa":"Kim, O., Okamoto, Y., Kaufmann, W., Brose, N., Shigemoto, R., &#38; Jonas, P. M. (2024). Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. <i>PLoS Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.3002879\">https://doi.org/10.1371/journal.pbio.3002879</a>","chicago":"Kim, Olena, Yuji Okamoto, Walter Kaufmann, Nils Brose, Ryuichi Shigemoto, and Peter M Jonas. “Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber Boutons.” <i>PLoS Biology</i>. Public Library of Science, 2024. <a href=\"https://doi.org/10.1371/journal.pbio.3002879\">https://doi.org/10.1371/journal.pbio.3002879</a>.","mla":"Kim, Olena, et al. “Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber Boutons.” <i>PLoS Biology</i>, vol. 22, no. 11, e3002879, Public Library of Science, 2024, doi:<a href=\"https://doi.org/10.1371/journal.pbio.3002879\">10.1371/journal.pbio.3002879</a>.","ama":"Kim O, Okamoto Y, Kaufmann W, Brose N, Shigemoto R, Jonas PM. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. <i>PLoS Biology</i>. 2024;22(11). doi:<a href=\"https://doi.org/10.1371/journal.pbio.3002879\">10.1371/journal.pbio.3002879</a>","ista":"Kim O, Okamoto Y, Kaufmann W, Brose N, Shigemoto R, Jonas PM. 2024. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. PLoS Biology. 22(11), e3002879."},"year":"2024","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":22,"language":[{"iso":"eng"}],"pmid":1,"date_published":"2024-11-18T00:00:00Z","external_id":{"isi":["001358568700003"],"pmid":["39556620"]},"has_accepted_license":"1","fulldoi":"https://doi.org/10.1371/journal.pbio.3002879","ddc":["570"],"type":"journal_article","article_processing_charge":"Yes","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"PreCl"}],"day":"18","publication_identifier":{"eissn":["1545-7885"],"issn":["1544-9173"]},"scopus_import":"1","author":[{"full_name":"Kim, Olena","first_name":"Olena","id":"3F8ABDDA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2344-1039","last_name":"Kim"},{"last_name":"Okamoto","orcid":"0000-0003-0408-6094","full_name":"Okamoto, Yuji","id":"3337E116-F248-11E8-B48F-1D18A9856A87","first_name":"Yuji"},{"orcid":"0000-0001-9735-5315","last_name":"Kaufmann","full_name":"Kaufmann, Walter","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","first_name":"Walter"},{"last_name":"Brose","full_name":"Brose, Nils","first_name":"Nils"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"orcid":"0000-0001-5001-4804","last_name":"Jonas","full_name":"Jonas, Peter M","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"article_number":"e3002879","corr_author":"1"},{"department":[{"_id":"PeJo"},{"_id":"RySh"},{"_id":"EM-Fac"}],"date_created":"2024-10-11T10:12:17Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","month":"10","ec_funded":1,"_id":"18296","file_date_updated":"2024-10-11T10:04:23Z","oa_version":"Submitted Version","file":[{"date_updated":"2024-10-11T10:04:19Z","file_id":"18297","success":1,"file_name":"Kim_et_al_2024_PlosBio_Source_data.zip","creator":"okim","file_size":164382,"checksum":"0a977e7df54c418251b10dfd3f8a015c","relation":"main_file","access_level":"open_access","content_type":"application/zip","date_created":"2024-10-11T10:04:19Z"},{"date_created":"2024-10-11T10:04:23Z","content_type":"text/plain","access_level":"open_access","relation":"main_file","checksum":"5b9343d6b2035ac3185e390fad4d3830","file_size":654,"creator":"okim","file_name":"info.txt","success":1,"date_updated":"2024-10-11T10:04:23Z","file_id":"18298"}],"date_updated":"2026-09-14T08:48:01Z","oa":1,"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"18603"}]},"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2024","citation":{"short":"O. Kim, (2024).","ieee":"O. Kim, “Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons.” Institute of Science and Technology Austria, 2024.","chicago":"Kim, Olena. “Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber Boutons.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:18296\">https://doi.org/10.15479/AT:ISTA:18296</a>.","apa":"Kim, O. (2024). Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:18296\">https://doi.org/10.15479/AT:ISTA:18296</a>","ama":"Kim O. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18296\">10.15479/AT:ISTA:18296</a>","mla":"Kim, Olena. <i>Presynaptic CAMP-PKA-Mediated Potentiation Induces Reconfiguration of Synaptic Vesicle Pools and Channel-Vesicle Coupling at Hippocampal Mossy Fiber Boutons</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18296\">10.15479/AT:ISTA:18296</a>.","ista":"Kim O. 2024. Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:18296\">10.15479/AT:ISTA:18296</a>."},"doi":"10.15479/AT:ISTA:18296","status":"public","publisher":"Institute of Science and Technology Austria","project":[{"grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse"}],"abstract":[{"lang":"eng","text":"It is widely believed that information storage in neuronal circuits involves nanoscopic structural changes at synapses, resulting in the formation of synaptic engrams. However, direct evidence for this hypothesis is lacking. To test this conjecture, we combined chemical potentiation, functional analysis by paired pre-postsynaptic recordings, and structural analysis by electron microscopy (EM) and freeze-fracture replica labeling (FRL) at the murine hippocampal mossy fiber synapse, a key synapse in the trisynaptic circuit of the hippocampus. Biophysical analysis of synaptic transmission revealed that forskolin-induced chemical potentiation increased the readily releasable vesicle pool size and vesicular release probability by 146% and 49%, respectively. Structural analysis of mossy fiber synapses by EM and FRL demonstrated an increase in the number of vesicles close to the plasma membrane and the number of clusters of the priming protein Munc13-1, indicating an increase in the number of both docked and primed vesicles. Furthermore, FRL analysis revealed a significant reduction of the distance between Munc13-1 and CaV2.1 Ca2+ channels, suggesting reconfiguration of the channel-vesicle coupling nanotopography. Our results indicate that presynaptic plasticity is associated with structural reorganization of active zones. We propose that changes in potential nanoscopic organization at synaptic vesicle release sites may be correlates of learning and memory at a plastic central synapse."}],"title":"Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons","ddc":["570"],"fulldoi":"https://doi.org/10.15479/AT:ISTA:18296","has_accepted_license":"1","date_published":"2024-10-11T00:00:00Z","keyword":["Hippocampal mossy fiber synapses","short-term potentiation","long-term potentiation","presynaptic plasticity","electron microscopy","freeze-fracture replica labeling","paired recordings","forskolin","cyclic adenosine monophosphate (cAMP)","protein kinase A (PKA)","neuromodulation","synaptic vesicle pools","presynaptic Ca2+ channels","Munc13","docking","priming","active zone"],"corr_author":"1","author":[{"first_name":"Olena","id":"3F8ABDDA-F248-11E8-B48F-1D18A9856A87","full_name":"Kim, Olena","last_name":"Kim","orcid":"0000-0003-2344-1039"}],"day":"11","article_processing_charge":"No","type":"research_data","contributor":[{"last_name":"Kim","contributor_type":"researcher","id":"3F8ABDDA-F248-11E8-B48F-1D18A9856A87","first_name":"Olena"},{"first_name":"Yuji","contributor_type":"researcher","id":"3337E116-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0408-6094","last_name":"Okamoto"},{"orcid":"0000-0001-9735-5315","last_name":"Kaufmann","contributor_type":"researcher","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","first_name":"Walter"},{"first_name":"Nils ","contributor_type":"researcher","last_name":"Brose"},{"first_name":"Ryuichi","contributor_type":"researcher","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"last_name":"Jonas","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","contributor_type":"supervisor"}]},{"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":690,"researchdata_availability":"no","year":"2024","publication_status":"published","citation":{"ama":"Shenar T, Bodensteiner J, Sana H, et al. Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC. <i>Astronomy &#38; Astrophysics</i>. 2024;690. doi:<a href=\"https://doi.org/10.1051/0004-6361/202451586\">10.1051/0004-6361/202451586</a>","mla":"Shenar, T., et al. “Binarity at LOw Metallicity (BLOeM): A Spectroscopic VLT Monitoring Survey of Massive Stars in the SMC.” <i>Astronomy &#38; Astrophysics</i>, vol. 690, A289, EDP Sciences, 2024, doi:<a href=\"https://doi.org/10.1051/0004-6361/202451586\">10.1051/0004-6361/202451586</a>.","ista":"Shenar T, Bodensteiner J, Sana H, Crowther PA, Lennon DJ, Abdul-Masih M, Almeida LA, Backs F, Berlanas SR, Bernini-Peron M, Bestenlehner JM, Bowman DM, Bronner VA, Britavskiy N, De Koter A, De Mink SE, Deshmukh K, Evans CJ, Fabry M, Gieles M, Gilkis A, González-Torà G, Gräfener G, Götberg YLL, Hawcroft C, Hénault-Brunet V, Herrero A, Holgado G, Janssens S, Johnston C, Josiek J, Justham S, Kalari VM, Katabi ZZ, Keszthelyi Z, Klencki J, Kubát J, Kubátová B, Langer N, Lefever RR, Ludwig B, Mackey J, Mahy L, Maíz Apellániz J, Mandel I, Maravelias G, Marchant P, Menon A, Najarro F, Oskinova LM, O’Grady AJG, Ovadia R, Patrick LR, Pauli D, Pawlak M, Ramachandran V, Renzo M, Rocha DF, Sander AAC, Sayada T, Schneider FRN, Schootemeijer A, Schösser EC, Schürmann C, Sen K, Shahaf S, Simón-Díaz S, Stoop M, Toonen S, Tramper F, Van Loon JT, Valli R, Van Son LAC, Vigna-Gómez A, Villaseñor JI, Vink JS, Wang C, Willcox R. 2024. Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC. Astronomy &#38; Astrophysics. 690, A289.","short":"T. Shenar, J. Bodensteiner, H. Sana, P.A. Crowther, D.J. Lennon, M. Abdul-Masih, L.A. Almeida, F. Backs, S.R. Berlanas, M. Bernini-Peron, J.M. Bestenlehner, D.M. Bowman, V.A. Bronner, N. Britavskiy, A. De Koter, S.E. De Mink, K. Deshmukh, C.J. Evans, M. Fabry, M. Gieles, A. Gilkis, G. González-Torà, G. Gräfener, Y.L.L. Götberg, C. Hawcroft, V. Hénault-Brunet, A. Herrero, G. Holgado, S. Janssens, C. Johnston, J. Josiek, S. Justham, V.M. Kalari, Z.Z. Katabi, Z. Keszthelyi, J. Klencki, J. Kubát, B. Kubátová, N. Langer, R.R. Lefever, B. Ludwig, J. Mackey, L. Mahy, J. Maíz Apellániz, I. Mandel, G. Maravelias, P. Marchant, A. Menon, F. Najarro, L.M. Oskinova, A.J.G. O’Grady, R. Ovadia, L.R. Patrick, D. Pauli, M. Pawlak, V. Ramachandran, M. Renzo, D.F. Rocha, A.A.C. Sander, T. Sayada, F.R.N. Schneider, A. Schootemeijer, E.C. Schösser, C. Schürmann, K. Sen, S. Shahaf, S. Simón-Díaz, M. Stoop, S. Toonen, F. Tramper, J.T. Van Loon, R. Valli, L.A.C. Van Son, A. Vigna-Gómez, J.I. Villaseñor, J.S. Vink, C. Wang, R. Willcox, Astronomy &#38; Astrophysics 690 (2024).","ieee":"T. Shenar <i>et al.</i>, “Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC,” <i>Astronomy &#38; Astrophysics</i>, vol. 690. EDP Sciences, 2024.","chicago":"Shenar, T., J. Bodensteiner, H. Sana, P. A. Crowther, D. J. Lennon, M. Abdul-Masih, L. A. Almeida, et al. “Binarity at LOw Metallicity (BLOeM): A Spectroscopic VLT Monitoring Survey of Massive Stars in the SMC.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2024. <a href=\"https://doi.org/10.1051/0004-6361/202451586\">https://doi.org/10.1051/0004-6361/202451586</a>.","apa":"Shenar, T., Bodensteiner, J., Sana, H., Crowther, P. A., Lennon, D. J., Abdul-Masih, M., … Willcox, R. (2024). Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/202451586\">https://doi.org/10.1051/0004-6361/202451586</a>"},"OA_place":"publisher","OA_type":"hybrid","doi":"10.1051/0004-6361/202451586","publisher":"EDP Sciences","status":"public","quality_controlled":"1","title":"Binarity at LOw Metallicity (BLOeM): A spectroscopic VLT monitoring survey of massive stars in the SMC","abstract":[{"lang":"eng","text":"Surveys in the Milky Way and Large Magellanic Cloud have revealed that the majority of massive stars will interact with companions during their lives. However, knowledge of the binary properties of massive stars at low metallicity, and therefore in conditions approaching those of the Early Universe, remain sparse. We present the Binarity at LOw Metallicity (BLOeM) campaign, an ESO large programme designed to obtain 25 epochs of spectroscopy for 929 massive stars in the Small Magellanic Cloud, allowing us to probe multiplicity in the lowest-metallicity conditions to date (Z = 0.2 Z⊙). BLOeM will provide (i) the binary fraction, (ii) the orbital configurations of systems with periods of P ≲ 3 yr, (iii) dormant black-hole binary candidates (OB+BH), and (iv) a legacy database of physical parameters of massive stars at low metallicity. Main sequence (OB-type) and evolved (OBAF-type) massive stars are observed with the LR02 setup of the GIRAFFE instrument of the Very Large Telescope (3960–4570 Å resolving power R = 6200; typical signal-to-noise ratio(S/N) ≈70–100). This paper utilises the first nine epochs obtained over a three-month time period. We describe the survey and data reduction, perform a spectral classification of the stacked spectra, and construct a Hertzsprung-Russell diagram of the sample via spectral-type and photometric calibrations. Our detailed classification reveals that the sample covers spectral types from O4 to F5, spanning the effective temperature and luminosity ranges 6.5 ≲ Teff/kK ≲ 45 and 3.7 < log L/L⊙ < 6.1 and initial masses of 8 ≲ Mini ≲ 80 M⊙. The sample comprises 159 O-type stars, 331 early B-type (B0–3) dwarfs and giants (luminosity classes V–III), 303 early B-type supergiants (II–I), and 136 late-type BAF supergiants. At least 82 stars are OBe stars: 20 O-type and 62 B-type (13% and 11% of the respective samples). In addition, the sample includes 4 high-mass X-ray binaries, 3 stars resembling luminous blue variables, 2 bloated stripped-star candidates, 2 candidate magnetic stars, and 74 eclipsing binaries."}],"acknowledgement":"The research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement numbers 772225: MULTIPLES). PAC and JMB are supported by the Science and Technology Facilities Council research grant ST/V000853/1 (PI. V. Dhillon). DMB gratefully acknowledges support from UK Research and Innovation (UKRI) in the form of a Frontier Research grant under the UK government’s ERC Horizon Europe funding guarantee (SYMPHONY; PI Bowman; grant number: EP/Y031059/1), and a Royal Society University Research Fellowship (PI Bowman; grant number: URF\\R1\\231631). ZK acknowledges support from JSPS Kakenhi Grant-in-Aid for Scientific Research (23K19071). IM acknowledges support from the Australian Research Council (ARC) Centre of Excellence for Gravitational Wave Discovery (OzGrav), through project number CE230100016. AACS, VR, RRL, and MBP are funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) in the form of an Emmy Noether Research Group – Project-ID 445674056 (SA4064/1-1, PI Sander). GGT and JJ are supported by the German Deutsche Forschungsgemeinschaft (DFG) under Project-ID 496854903 (SA4064/2-1, PI Sander) VR, GGT, and AACS further acknowledge support from the Federal Ministry of Education and Research (BMBF) and the Baden-Württemberg Ministry of Science as part of the Excellence Strategy of the German Federal and State Governments. ECS acknowledges financial support by the Federal Ministry for Economic Affairs and Climate Action (BMWK) via the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt, DLR) grant 50 OR 2306 (PI: Ramachandran/Sander). This work has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 945806) and is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2181/1-390900948 (the Heidelberg STRUCTURES Excellence Cluster). LMO is thankful for the funding provided by the DFG grant 443790621. This paper benefited from discussions at the International Space Science Institute (ISSI) in Bern through ISSI International Team project 512 (Multiwavelength View on Massive Stars in the Era of Multimessenger Astronomy). DP acknowledges financial support by the Deutsches Zentrum für Luft und Raumfahrt (DLR) grant FKZ 50OR2005. JIV acknowledges the European Research Council for support from the ERC Advanced grant ERC-2021-ADG101054731. JSV is supported by STFC (Science and Technology Facilities Council) funding under grant number ST/V000233/1. GH, SS-D, SRB and AH acknowledge support from the State Research Agency (AEI) of the Spanish Ministry of Science and Innovation (MICIN) and the European Regional Development Fund, FEDER under grants PID2021-122397NB-C21 and CEX2019-000920-S. SRB also acknowledges financial support by NextGeneration EU/PRTR and MIU (UNI/551/2021) through grant Margarita Salas-ULL. DFR is thankful for the support of the CAPES-Br and FAPERJ/DSC-10 (SEI-260003/001630/2023). F.N., and L.R.P. acknowledge support by grants PID2019-105552RB-C41 and PID2022-137779OB-C41 funded by MCIN/AEI/10.13039/501100011033 by “ERDF A way of making Europe”. MG acknowledges financial support from the grants PID2021-125485NB-C22, CEX2019-000918-M funded by MCIN/AEI/10.13039/501100011033 (State Agency for Research of the Spanish Ministry of Science and Innovation) and SGR-2021-01069 (AGAUR). GM acknowledges funding support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 772086). JMA acknowledges support from the Spanish Government Ministerio de Ciencia e Innovación and Agencia Estatal de Investigación (10.13 039/501 100 011 033) through grant PID2022-136640 NB-C22 and from the Consejo Superior de Investigaciones Científicas (CSIC) through grant 2022-AEP 005. MP is supported by the BEKKER fellowship BPN/BEK/2022/1/00106 from the Polish National Agency for Academic Exchange. KS is funded by the National Science Center (NCN), Poland, under grant number OPUS 2021/41/B/ST9/00757. JM acknowledges support from a Royal Society-Science Foundation Ireland University Research Fellowship. SJ acknowledges support from the FWO PhD fellowship under project 11E1721N. FB acknowledges the support of the European Research Council (ERC) Horizon Europe under grant agreement number 101044048.","article_type":"original","department":[{"_id":"YlGo"}],"date_created":"2024-11-03T23:01:44Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","month":"10","_id":"18492","intvolume":"       690","file_date_updated":"2024-11-04T09:52:26Z","publication":"Astronomy & Astrophysics","oa_version":"Published Version","oa":1,"isi":1,"date_updated":"2026-09-16T10:50:17Z","file":[{"creator":"dernst","file_name":"2024_AstronomyAstrophysics_Shenar.pdf","date_updated":"2024-11-04T09:52:26Z","file_id":"18500","success":1,"content_type":"application/pdf","date_created":"2024-11-04T09:52:26Z","access_level":"open_access","relation":"main_file","checksum":"b378b36726591f3479a927d924ab8e77","file_size":4267349}],"das_tickbox":"1","supplementarymaterial":"no","article_number":"A289","author":[{"first_name":"T.","full_name":"Shenar, T.","last_name":"Shenar"},{"first_name":"J.","full_name":"Bodensteiner, J.","last_name":"Bodensteiner"},{"first_name":"H.","full_name":"Sana, H.","last_name":"Sana"},{"last_name":"Crowther","full_name":"Crowther, P. A.","first_name":"P. A."},{"last_name":"Lennon","first_name":"D. J.","full_name":"Lennon, D. J."},{"full_name":"Abdul-Masih, M.","first_name":"M.","last_name":"Abdul-Masih"},{"last_name":"Almeida","full_name":"Almeida, L. A.","first_name":"L. A."},{"first_name":"F.","full_name":"Backs, F.","last_name":"Backs"},{"last_name":"Berlanas","full_name":"Berlanas, S. R.","first_name":"S. R."},{"full_name":"Bernini-Peron, M.","first_name":"M.","last_name":"Bernini-Peron"},{"first_name":"J. M.","full_name":"Bestenlehner, J. M.","last_name":"Bestenlehner"},{"last_name":"Bowman","full_name":"Bowman, D. M.","first_name":"D. M."},{"first_name":"V. A.","full_name":"Bronner, V. A.","last_name":"Bronner"},{"last_name":"Britavskiy","full_name":"Britavskiy, N.","first_name":"N."},{"last_name":"De Koter","full_name":"De Koter, A.","first_name":"A."},{"last_name":"De Mink","full_name":"De Mink, S. E.","first_name":"S. E."},{"full_name":"Deshmukh, K.","first_name":"K.","last_name":"Deshmukh"},{"first_name":"C. J.","full_name":"Evans, C. J.","last_name":"Evans"},{"first_name":"M.","full_name":"Fabry, M.","last_name":"Fabry"},{"first_name":"M.","full_name":"Gieles, M.","last_name":"Gieles"},{"full_name":"Gilkis, A.","first_name":"A.","last_name":"Gilkis"},{"last_name":"González-Torà","first_name":"G.","full_name":"González-Torà, G."},{"first_name":"G.","full_name":"Gräfener, G.","last_name":"Gräfener"},{"orcid":"0000-0002-6960-6911","last_name":"Götberg","full_name":"Götberg, Ylva Louise Linsdotter","first_name":"Ylva Louise Linsdotter","id":"d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d"},{"last_name":"Hawcroft","full_name":"Hawcroft, C.","first_name":"C."},{"last_name":"Hénault-Brunet","first_name":"V.","full_name":"Hénault-Brunet, V."},{"last_name":"Herrero","full_name":"Herrero, A.","first_name":"A."},{"first_name":"G.","full_name":"Holgado, G.","last_name":"Holgado"},{"last_name":"Janssens","first_name":"S.","full_name":"Janssens, S."},{"last_name":"Johnston","first_name":"C.","full_name":"Johnston, C."},{"last_name":"Josiek","full_name":"Josiek, J.","first_name":"J."},{"last_name":"Justham","full_name":"Justham, S.","first_name":"S."},{"last_name":"Kalari","first_name":"V. M.","full_name":"Kalari, V. M."},{"last_name":"Katabi","first_name":"Z. Z.","full_name":"Katabi, Z. Z."},{"last_name":"Keszthelyi","first_name":"Z.","full_name":"Keszthelyi, Z."},{"full_name":"Klencki, J.","first_name":"J.","last_name":"Klencki"},{"last_name":"Kubát","full_name":"Kubát, J.","first_name":"J."},{"first_name":"B.","full_name":"Kubátová, B.","last_name":"Kubátová"},{"first_name":"N.","full_name":"Langer, N.","last_name":"Langer"},{"full_name":"Lefever, R. R.","first_name":"R. R.","last_name":"Lefever"},{"last_name":"Ludwig","full_name":"Ludwig, B.","first_name":"B."},{"full_name":"Mackey, J.","first_name":"J.","last_name":"Mackey"},{"full_name":"Mahy, L.","first_name":"L.","last_name":"Mahy"},{"first_name":"J.","full_name":"Maíz Apellániz, J.","last_name":"Maíz Apellániz"},{"last_name":"Mandel","first_name":"I.","full_name":"Mandel, I."},{"last_name":"Maravelias","first_name":"G.","full_name":"Maravelias, G."},{"first_name":"P.","full_name":"Marchant, P.","last_name":"Marchant"},{"full_name":"Menon, A.","first_name":"A.","last_name":"Menon"},{"last_name":"Najarro","full_name":"Najarro, F.","first_name":"F."},{"first_name":"L. M.","full_name":"Oskinova, L. M.","last_name":"Oskinova"},{"first_name":"A. J.G.","full_name":"O'Grady, A. J.G.","last_name":"O'Grady"},{"last_name":"Ovadia","full_name":"Ovadia, R.","first_name":"R."},{"last_name":"Patrick","full_name":"Patrick, L. R.","first_name":"L. R."},{"last_name":"Pauli","first_name":"D.","full_name":"Pauli, D."},{"last_name":"Pawlak","full_name":"Pawlak, M.","first_name":"M."},{"full_name":"Ramachandran, V.","first_name":"V.","last_name":"Ramachandran"},{"full_name":"Renzo, M.","first_name":"M.","last_name":"Renzo"},{"last_name":"Rocha","first_name":"D. F.","full_name":"Rocha, D. F."},{"first_name":"A. A.C.","full_name":"Sander, A. A.C.","last_name":"Sander"},{"last_name":"Sayada","full_name":"Sayada, T.","first_name":"T."},{"last_name":"Schneider","full_name":"Schneider, F. R.N.","first_name":"F. R.N."},{"last_name":"Schootemeijer","full_name":"Schootemeijer, A.","first_name":"A."},{"first_name":"E. C.","full_name":"Schösser, E. C.","last_name":"Schösser"},{"first_name":"C.","full_name":"Schürmann, C.","last_name":"Schürmann"},{"first_name":"K.","full_name":"Sen, K.","last_name":"Sen"},{"last_name":"Shahaf","full_name":"Shahaf, S.","first_name":"S."},{"last_name":"Simón-Díaz","first_name":"S.","full_name":"Simón-Díaz, S."},{"last_name":"Stoop","full_name":"Stoop, M.","first_name":"M."},{"last_name":"Toonen","first_name":"S.","full_name":"Toonen, S."},{"first_name":"F.","full_name":"Tramper, F.","last_name":"Tramper"},{"last_name":"Van Loon","full_name":"Van Loon, J. Th","first_name":"J. Th"},{"last_name":"Valli","first_name":"R.","full_name":"Valli, R."},{"full_name":"Van Son, L. A.C.","first_name":"L. A.C.","last_name":"Van Son"},{"last_name":"Vigna-Gómez","first_name":"A.","full_name":"Vigna-Gómez, A."},{"last_name":"Villaseñor","first_name":"J. I.","full_name":"Villaseñor, J. I."},{"first_name":"J. S.","full_name":"Vink, J. S.","last_name":"Vink"},{"first_name":"C.","full_name":"Wang, C.","last_name":"Wang"},{"last_name":"Willcox","full_name":"Willcox, R.","first_name":"R."}],"scopus_import":"1","publication_identifier":{"issn":["0004-6361"],"eissn":["1432-0746"]},"day":"01","article_processing_charge":"Yes (in subscription journal)","type":"journal_article","fulldoi":"https://doi.org/10.1051/0004-6361/202451586","ddc":["520"],"has_accepted_license":"1","arxiv":1,"external_id":{"arxiv":["2407.14593"],"isi":["001336770600014"]},"date_published":"2024-10-01T00:00:00Z","language":[{"iso":"eng"}]},{"supplementarymaterial":"no","corr_author":"1","article_number":"013141","author":[{"orcid":"0000-0003-0582-2946","last_name":"Agafonova","id":"09501ff6-dca7-11ea-a8ae-b3e0b9166e80","first_name":"Sofya","full_name":"Agafonova, Sofya"},{"id":"4328fa4c-f128-11eb-9611-c107b0fe4d51","first_name":"Umang","full_name":"Mishra, Umang","last_name":"Mishra"},{"id":"2E054C4C-F248-11E8-B48F-1D18A9856A87","first_name":"Fritz R","full_name":"Diorico, Fritz R","last_name":"Diorico","orcid":"0000-0002-4947-8924"},{"first_name":"Onur","id":"4C02D85E-F248-11E8-B48F-1D18A9856A87","full_name":"Hosten, Onur","last_name":"Hosten","orcid":"0000-0002-2031-204X"}],"publication_identifier":{"eissn":["2643-1564"]},"scopus_import":"1","day":"05","article_processing_charge":"Yes","type":"journal_article","ddc":["530"],"fulldoi":"https://doi.org/10.1103/physrevresearch.6.013141","has_accepted_license":"1","arxiv":1,"date_published":"2024-02-05T00:00:00Z","external_id":{"arxiv":["2306.12804"]},"language":[{"iso":"eng"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"researchdata_availability":"no","year":"2024","volume":6,"citation":{"ama":"Agafonova S, Mishra U, Diorico FR, Hosten O. Zigzag optical cavity for sensing and controlling torsional motion. <i>Physical Review Research</i>. 2024;6(1). doi:<a href=\"https://doi.org/10.1103/physrevresearch.6.013141\">10.1103/physrevresearch.6.013141</a>","mla":"Agafonova, Sofia, et al. “Zigzag Optical Cavity for Sensing and Controlling Torsional Motion.” <i>Physical Review Research</i>, vol. 6, no. 1, 013141, American Physical Society, 2024, doi:<a href=\"https://doi.org/10.1103/physrevresearch.6.013141\">10.1103/physrevresearch.6.013141</a>.","ista":"Agafonova S, Mishra U, Diorico FR, Hosten O. 2024. Zigzag optical cavity for sensing and controlling torsional motion. Physical Review Research. 6(1), 013141.","short":"S. Agafonova, U. Mishra, F.R. Diorico, O. Hosten, Physical Review Research 6 (2024).","ieee":"S. Agafonova, U. Mishra, F. R. Diorico, and O. Hosten, “Zigzag optical cavity for sensing and controlling torsional motion,” <i>Physical Review Research</i>, vol. 6, no. 1. American Physical Society, 2024.","chicago":"Agafonova, Sofia, Umang Mishra, Fritz R Diorico, and Onur Hosten. “Zigzag Optical Cavity for Sensing and Controlling Torsional Motion.” <i>Physical Review Research</i>. American Physical Society, 2024. <a href=\"https://doi.org/10.1103/physrevresearch.6.013141\">https://doi.org/10.1103/physrevresearch.6.013141</a>.","apa":"Agafonova, S., Mishra, U., Diorico, F. R., &#38; Hosten, O. (2024). Zigzag optical cavity for sensing and controlling torsional motion. <i>Physical Review Research</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevresearch.6.013141\">https://doi.org/10.1103/physrevresearch.6.013141</a>"},"publication_status":"published","OA_place":"publisher","OA_type":"gold","doi":"10.1103/physrevresearch.6.013141","issue":"1","status":"public","publisher":"American Physical Society","project":[{"name":"A quantum hybrid of atoms and milligram-scale pendulums: towards gravitational quantum mechanics","grant_number":"101087907","_id":"bdb2a702-d553-11ed-ba76-f12e3e5a3bc6"}],"quality_controlled":"1","title":"Zigzag optical cavity for sensing and controlling torsional motion","abstract":[{"text":"Precision sensing and manipulation of milligram-scale mechanical oscillators has attracted growing interest in the fields of table-top explorations of gravity and tests of quantum mechanics at macroscopic scales. Torsional oscillators present an opportunity in this regard due to their remarked isolation from environmental noise. For torsional motion, an effective employment of optical cavities to enhance optomechanical interactions—as already established for linear oscillators—so far faced certain challenges. Here, we propose a concept for sensing and manipulating torsional motion, where exclusively the torsional rotations of a pendulum are mapped onto the path length of a single two-mirror optical cavity. The concept inherently alleviates many limitations of previous approaches. A proof-of-principle experiment is conducted with a rigidly controlled pendulum to explore the sensing aspects of the concept and to identify practical limitations in a potential state-of-the art setup. Based on this study, we anticipate development of precision torque sensors utilizing torsional pendulums that can support sensitivities below 10−19Nm/√Hz, while the motion of the pendulums are dominated by quantum radiation pressure noise at sub-microwatts of incoming laser power. These developments will provide horizons for experiments at the interface of quantum mechanics and gravity.","lang":"eng"}],"acknowledgement":"We thank Pere Rosselló for his contributions to the initial modeling of the presented sensing technique. This work was supported by Institute of Science and Technology Austria, and\r\nthe European Research Council under Grant No. 101087907 (ERC CoG QuHAMP).","department":[{"_id":"OnHo"}],"article_type":"original","APC_amount":"2933,65 EUR","date_created":"2024-02-12T11:42:18Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","month":"02","_id":"14980","DOAJ_listed":"1","file_date_updated":"2024-02-12T11:46:50Z","intvolume":"         6","publication":"Physical Review Research","oa_version":"Published Version","date_updated":"2026-09-17T09:13:08Z","file":[{"creator":"dernst","file_name":"2024_PhysicalRevResearch_Agafonova.pdf","date_updated":"2024-02-12T11:46:50Z","file_id":"14981","success":1,"access_level":"open_access","content_type":"application/pdf","date_created":"2024-02-12T11:46:50Z","checksum":"3a39ebffb24c1cc1dd0b547a726dc52d","file_size":1437167,"relation":"main_file"}],"oa":1,"das_tickbox":"0"},{"ddc":["570"],"fulldoi":"https://doi.org/10.1146/annurev-biophys-070323-022428","has_accepted_license":"1","date_published":"2024-07-01T00:00:00Z","external_id":{"pmid":["38346243"],"isi":["001278237500012"]},"pmid":1,"language":[{"iso":"eng"}],"supplementarymaterial":"no","page":"247-273","corr_author":"1","author":[{"last_name":"Schanda","orcid":"0000-0002-9350-7606","full_name":"Schanda, Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","first_name":"Paul"},{"full_name":"Haran, Gilad","first_name":"Gilad","last_name":"Haran"}],"publication_identifier":{"eissn":["1936-1238"],"issn":["1936-122X"]},"scopus_import":"1","day":"01","article_processing_charge":"No","type":"journal_article","department":[{"_id":"PaSc"}],"article_type":"original","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2025-01-27T13:40:34Z","month":"07","_id":"18910","file_date_updated":"2025-01-27T13:44:59Z","intvolume":"        53","publication":"Annual Review of Biophysics","oa_version":"Published Version","isi":1,"file":[{"file_id":"18911","date_updated":"2025-01-27T13:44:59Z","success":1,"file_name":"2024_AnnualReviews_Schanda.pdf","creator":"dernst","relation":"main_file","file_size":3025589,"checksum":"c90861542ae3f9147939030d5bafed3c","content_type":"application/pdf","date_created":"2025-01-27T13:44:59Z","access_level":"open_access"}],"date_updated":"2026-09-17T09:44:33Z","oa":1,"das_tickbox":"0","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"researchdata_availability":"no","year":"2024","volume":53,"publication_status":"published","OA_place":"publisher","citation":{"apa":"Schanda, P., &#38; Haran, G. (2024). NMR and single-molecule FRET insights into fast protein motions and their relation to function. <i>Annual Review of Biophysics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-biophys-070323-022428\">https://doi.org/10.1146/annurev-biophys-070323-022428</a>","chicago":"Schanda, Paul, and Gilad Haran. “NMR and Single-Molecule FRET Insights into Fast Protein Motions and Their Relation to Function.” <i>Annual Review of Biophysics</i>. Annual Reviews, 2024. <a href=\"https://doi.org/10.1146/annurev-biophys-070323-022428\">https://doi.org/10.1146/annurev-biophys-070323-022428</a>.","ieee":"P. Schanda and G. Haran, “NMR and single-molecule FRET insights into fast protein motions and their relation to function,” <i>Annual Review of Biophysics</i>, vol. 53. Annual Reviews, pp. 247–273, 2024.","short":"P. Schanda, G. Haran, Annual Review of Biophysics 53 (2024) 247–273.","ista":"Schanda P, Haran G. 2024. NMR and single-molecule FRET insights into fast protein motions and their relation to function. Annual Review of Biophysics. 53, 247–273.","mla":"Schanda, Paul, and Gilad Haran. “NMR and Single-Molecule FRET Insights into Fast Protein Motions and Their Relation to Function.” <i>Annual Review of Biophysics</i>, vol. 53, Annual Reviews, 2024, pp. 247–73, doi:<a href=\"https://doi.org/10.1146/annurev-biophys-070323-022428\">10.1146/annurev-biophys-070323-022428</a>.","ama":"Schanda P, Haran G. NMR and single-molecule FRET insights into fast protein motions and their relation to function. <i>Annual Review of Biophysics</i>. 2024;53:247-273. doi:<a href=\"https://doi.org/10.1146/annurev-biophys-070323-022428\">10.1146/annurev-biophys-070323-022428</a>"},"OA_type":"hybrid","doi":"10.1146/annurev-biophys-070323-022428","status":"public","project":[{"grant_number":"I05812","_id":"eb9c82eb-77a9-11ec-83b8-aadd536561cf","name":"AlloSpace. The emergence and mechanisms of allostery"}],"publisher":"Annual Reviews","quality_controlled":"1","title":"NMR and single-molecule FRET insights into fast protein motions and their relation to function","abstract":[{"text":"Proteins often undergo large-scale conformational transitions, in which secondary and tertiary structure elements (loops, helices, and domains) change their structures or their positions with respect to each other. Simple considerations suggest that such dynamics should be relatively fast, but the functional cycles of many proteins are often relatively slow. Sophisticated experimental methods are starting to tackle this dichotomy and shed light on the contribution of large-scale conformational dynamics to protein function. In this review, we focus on the contribution of single-molecule Förster resonance energy transfer and nuclear magnetic resonance (NMR) spectroscopies to the study of conformational dynamics. We briefly describe the state of the art in each of these techniques and then point out their similarities and differences, as well as the relative strengths and weaknesses of each. Several case studies, in which the connection between fast conformational dynamics and slower function has been demonstrated, are then introduced and discussed. These examples include both enzymes and large protein machines, some of which have been studied by both NMR and fluorescence spectroscopies.","lang":"eng"}],"acknowledgement":"G.H. is the incumbent of the Hilda Pomeraniec Memorial Professorial Chair. He has been partially funded by the European Research Council under the European Union's Horizon 2020 research and innovation program (grant 742637, SMALLOSTERY), by National Science Foundation–US-Israel Binational Science Foundation grant 2021700, and by an Israel Science Foundation Breakthrough grant (1924/22). P.S. acknowledges funding from the Austrian Science Fund (project “AlloSpace,” I05812) and intramural funding from the Institute of Science and Technology Austria."},{"month":"03","_id":"15117","ec_funded":1,"article_type":"review","department":[{"_id":"PeJo"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-03-17T23:00:57Z","isi":1,"date_updated":"2026-09-17T09:49:03Z","das_tickbox":"0","intvolume":"       383","oa_version":"None","publication":"Science","doi":"10.1126/science.adg6757","year":"2024","volume":383,"researchdata_availability":"no","publication_status":"published","citation":{"ieee":"D. H. Vandael and P. M. Jonas, “Structure, biophysics, and circuit function of a ‘giant’ cortical presynaptic terminal,” <i>Science</i>, vol. 383, no. 6687. AAAS, p. eadg6757, 2024.","short":"D.H. Vandael, P.M. Jonas, Science 383 (2024) eadg6757.","apa":"Vandael, D. H., &#38; Jonas, P. M. (2024). Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adg6757\">https://doi.org/10.1126/science.adg6757</a>","chicago":"Vandael, David H, and Peter M Jonas. “Structure, Biophysics, and Circuit Function of a ‘Giant’ Cortical Presynaptic Terminal.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adg6757\">https://doi.org/10.1126/science.adg6757</a>.","mla":"Vandael, David H., and Peter M. Jonas. “Structure, Biophysics, and Circuit Function of a ‘Giant’ Cortical Presynaptic Terminal.” <i>Science</i>, vol. 383, no. 6687, AAAS, 2024, p. eadg6757, doi:<a href=\"https://doi.org/10.1126/science.adg6757\">10.1126/science.adg6757</a>.","ama":"Vandael DH, Jonas PM. Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal. <i>Science</i>. 2024;383(6687):eadg6757. doi:<a href=\"https://doi.org/10.1126/science.adg6757\">10.1126/science.adg6757</a>","ista":"Vandael DH, Jonas PM. 2024. Structure, biophysics, and circuit function of a ‘giant’ cortical presynaptic terminal. Science. 383(6687), eadg6757."},"title":"Structure, biophysics, and circuit function of a \"giant\" cortical presynaptic terminal","abstract":[{"text":"The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of the hippocampus. Because of its comparatively large size, this synapse is accessible to direct presynaptic recording, allowing a rigorous investigation of the biophysical mechanisms of synaptic transmission and plasticity. Furthermore, because of its placement in the very center of the hippocampal memory circuit, this synapse seems to be critically involved in several higher network functions, such as learning, memory, pattern separation, and pattern completion. Recent work based on new technologies in both nanoanatomy and nanophysiology, including presynaptic patch-clamp recording, paired recording, super-resolution light microscopy, and freeze-fracture and “flash-and-freeze” electron microscopy, has provided new insights into the structure, biophysics, and network function of this intriguing synapse. This brings us one step closer to answering a fundamental question in neuroscience: how basic synaptic properties shape higher network computations.","lang":"eng"}],"acknowledgement":"We thank previous students, postdocs, and collaborators, particularly J. Geiger, and (in alphabetical order) H. Alle, J. Bischofberger, C. Borges-Merjane, D. Engel, M. Frotscher, S. Hallermann, M. Heckmann, S. Jamrichova, O. Kim, L. Li, K. Lichter, P. Lin, J. Lübke, Y. Okamoto, C. Pawlu, C. Schmidt-Hieber, N. Spruston, and N. Vyleta for their outstanding experimental contributions. We also thank P. Castillo, J. Geiger, T. Sakaba, S. Siegert, T. Vogels, and J. Watson for critically reading the manuscript, E. Kralli-Beller for text editing, and J. Malikovic and L. Slomianka for useful discussions. We apologize that, due to space constraints, not all relevant papers could be cited.\r\nThis project was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 692692, AdG “GIANTSYN”) and the Fonds zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein Award; P 36232-B, stand-alone grant), both to P.J.","publisher":"AAAS","project":[{"name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","grant_number":"692692"},{"name":"Synaptic communication in neuronal microcircuits","_id":"25C5A090-B435-11E9-9278-68D0E5697425","grant_number":"Z00312","call_identifier":"FWF"},{"name":"Mechanisms of GABA release in hippocampal circuits","_id":"bd88be38-d553-11ed-ba76-81d5a70a6ef5","grant_number":"P36232"}],"issue":"6687","status":"public","quality_controlled":"1","fulldoi":"https://doi.org/10.1126/science.adg6757","language":[{"iso":"eng"}],"date_published":"2024-03-08T00:00:00Z","external_id":{"isi":["001216996700015"],"pmid":["38452088"]},"pmid":1,"author":[{"orcid":"0000-0001-7577-1676","last_name":"Vandael","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87","first_name":"David H","full_name":"Vandael, David H"},{"orcid":"0000-0001-5001-4804","last_name":"Jonas","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M"}],"scopus_import":"1","publication_identifier":{"eissn":["1095-9203"]},"supplementarymaterial":"no","corr_author":"1","page":"eadg6757","article_processing_charge":"No","type":"journal_article","day":"08"},{"fulldoi":"https://doi.org/10.1201/9781003055211-8","date_published":"2024-09-05T00:00:00Z","language":[{"iso":"eng"}],"page":"66-72","supplementarymaterial":"no","scopus_import":"1","publication_identifier":{"eisbn":["9781003055211"]},"author":[{"first_name":"Jake","id":"63836096-4690-11EA-BD4E-32803DDC885E","full_name":"Watson, Jake","last_name":"Watson","orcid":"0000-0002-8698-3823"},{"last_name":"Arroyo-Urea","full_name":"Arroyo-Urea, Sandra","first_name":"Sandra"},{"last_name":"García-Nafría","first_name":"Javier","full_name":"García-Nafría, Javier"}],"place":"Boca Raton","day":"05","type":"book_chapter","article_processing_charge":"No","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-09-11T10:40:36Z","department":[{"_id":"PeJo"}],"editor":[{"last_name":"Liu","full_name":"Liu, Dongyou","first_name":"Dongyou"}],"_id":"18058","month":"09","oa_version":"None","publication":"Handbook of Molecular Biotechnology","das_tickbox":"0","date_updated":"2026-09-17T09:58:21Z","citation":{"ista":"Watson J, Arroyo-Urea S, García-Nafría J. 2024.DNA Cloning. In: Handbook of Molecular Biotechnology. , 66–72.","mla":"Watson, Jake, et al. “DNA Cloning.” <i>Handbook of Molecular Biotechnology</i>, edited by Dongyou Liu, 1st ed., CRC Press, 2024, pp. 66–72, doi:<a href=\"https://doi.org/10.1201/9781003055211-8\">10.1201/9781003055211-8</a>.","ama":"Watson J, Arroyo-Urea S, García-Nafría J. DNA Cloning. In: Liu D, ed. <i>Handbook of Molecular Biotechnology</i>. 1st ed. Boca Raton: CRC Press; 2024:66-72. doi:<a href=\"https://doi.org/10.1201/9781003055211-8\">10.1201/9781003055211-8</a>","apa":"Watson, J., Arroyo-Urea, S., &#38; García-Nafría, J. (2024). DNA Cloning. In D. Liu (Ed.), <i>Handbook of Molecular Biotechnology</i> (1st ed., pp. 66–72). Boca Raton: CRC Press. <a href=\"https://doi.org/10.1201/9781003055211-8\">https://doi.org/10.1201/9781003055211-8</a>","chicago":"Watson, Jake, Sandra Arroyo-Urea, and Javier García-Nafría. “DNA Cloning.” In <i>Handbook of Molecular Biotechnology</i>, edited by Dongyou Liu, 1st ed., 66–72. Boca Raton: CRC Press, 2024. <a href=\"https://doi.org/10.1201/9781003055211-8\">https://doi.org/10.1201/9781003055211-8</a>.","ieee":"J. Watson, S. Arroyo-Urea, and J. García-Nafría, “DNA Cloning,” in <i>Handbook of Molecular Biotechnology</i>, 1st ed., D. Liu, Ed. Boca Raton: CRC Press, 2024, pp. 66–72.","short":"J. Watson, S. Arroyo-Urea, J. García-Nafría, in:, D. Liu (Ed.), Handbook of Molecular Biotechnology, 1st ed., CRC Press, Boca Raton, 2024, pp. 66–72."},"publication_status":"published","year":"2024","researchdata_availability":"no","doi":"10.1201/9781003055211-8","quality_controlled":"1","publisher":"CRC Press","status":"public","edition":"1","abstract":[{"text":"DNA cloning is a core technique in biomedical and biotechnological research and is used to assemble and modify DNA fragments at will. While DNA cloning has traditionally relied on restriction enzymes, recent homology-based methods offer improved protocols together with seamless and directional assembly of desired products, overcoming the main disadvantages of restriction enzyme DNA cloning. This chapter provides a historical perspective on DNA cloning, presents a detailed discussion on state-of-the-art in vitro and in vivo homology-based methodologies, covering the basics of how to perform all major plasmid modifications (sub-cloning, site-directed mutagenesis, insertions, and deletions), and gives examples of how to apply these techniques for complex DNA cloning projects.","lang":"eng"}],"title":"DNA Cloning"},{"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2024","researchdata_availability":"no","volume":53,"publication_status":"published","citation":{"mla":"Lauwereyns, Jan, et al. “Toward a Common Interpretation of the 3Rs Principles in Animal Research.” <i>Lab Animal</i>, vol. 53, Springer Nature, 2024, pp. 347–50, doi:<a href=\"https://doi.org/10.1038/s41684-024-01476-2\">10.1038/s41684-024-01476-2</a>.","ama":"Lauwereyns J, Bajramovic J, Bert B, et al. Toward a common interpretation of the 3Rs principles in animal research. <i>Lab Animal</i>. 2024;53:347-350. doi:<a href=\"https://doi.org/10.1038/s41684-024-01476-2\">10.1038/s41684-024-01476-2</a>","ista":"Lauwereyns J, Bajramovic J, Bert B, Camenzind S, De Kock J, Elezović A, Erden S, Gonzalez-Uarquin F, Ulman YI, Hoffmann OI, Kitsara M, Kostomitsopoulos N, Neuhaus W, Petit-Demouliere B, Pollo S, Riso B, Schober S, Sotiropoulos A, Thomas A, Vitale A, Wilflingseder D, Ahluwalia A. 2024. Toward a common interpretation of the 3Rs principles in animal research. Lab Animal. 53, 347–350.","ieee":"J. Lauwereyns <i>et al.</i>, “Toward a common interpretation of the 3Rs principles in animal research,” <i>Lab Animal</i>, vol. 53. Springer Nature, pp. 347–350, 2024.","short":"J. Lauwereyns, J. Bajramovic, B. Bert, S. Camenzind, J. De Kock, A. Elezović, S. Erden, F. Gonzalez-Uarquin, Y.I. Ulman, O.I. Hoffmann, M. Kitsara, N. Kostomitsopoulos, W. Neuhaus, B. Petit-Demouliere, S. Pollo, B. Riso, S. Schober, A. Sotiropoulos, A. Thomas, A. Vitale, D. Wilflingseder, A. Ahluwalia, Lab Animal 53 (2024) 347–350.","apa":"Lauwereyns, J., Bajramovic, J., Bert, B., Camenzind, S., De Kock, J., Elezović, A., … Ahluwalia, A. (2024). Toward a common interpretation of the 3Rs principles in animal research. <i>Lab Animal</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41684-024-01476-2\">https://doi.org/10.1038/s41684-024-01476-2</a>","chicago":"Lauwereyns, Jan, Jeffrey Bajramovic, Bettina Bert, Samuel Camenzind, Joery De Kock, Alisa Elezović, Sevilay Erden, et al. “Toward a Common Interpretation of the 3Rs Principles in Animal Research.” <i>Lab Animal</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41684-024-01476-2\">https://doi.org/10.1038/s41684-024-01476-2</a>."},"OA_place":"publisher","OA_type":"hybrid","doi":"10.1038/s41684-024-01476-2","status":"public","publisher":"Springer Nature","quality_controlled":"1","abstract":[{"lang":"eng","text":"Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread recognition as basic guidelines for animal research. Over time, the 3Rs have transcended the research community, influencing policy decisions, animal welfare advocacy and public perception of animal experimentation. Despite their broad acceptance, interpretations of the 3Rs vary substantially, shaping statutory frameworks at various levels, with both technical and practical impacts."}],"title":"Toward a common interpretation of the 3Rs principles in animal research","acknowledgement":"This publication is based upon work from the Ethics Crossover Group within the COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by COST (European Cooperation in Science and Technology). We acknowledge the input and advice from Dr. Susanna Louhimies.","department":[{"_id":"PreCl"}],"article_type":"letter_note","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-11-24T23:01:49Z","month":"12","_id":"18587","file_date_updated":"2024-12-03T14:07:04Z","intvolume":"        53","oa_version":"Published Version","publication":"Lab Animal","isi":1,"date_updated":"2026-09-17T10:29:32Z","file":[{"file_name":"2024_LabAnimal_Lauwereyns.pdf","creator":"dernst","success":1,"date_updated":"2024-12-03T14:07:04Z","file_id":"18614","access_level":"open_access","date_created":"2024-12-03T14:07:04Z","content_type":"application/pdf","checksum":"67fc140f761581a291591f075e49b88d","file_size":967252,"relation":"main_file"}],"oa":1,"das_tickbox":"0","supplementarymaterial":"no","page":"347-350","author":[{"last_name":"Lauwereyns","first_name":"Jan","full_name":"Lauwereyns, Jan"},{"full_name":"Bajramovic, Jeffrey","first_name":"Jeffrey","last_name":"Bajramovic"},{"full_name":"Bert, Bettina","first_name":"Bettina","last_name":"Bert"},{"first_name":"Samuel","full_name":"Camenzind, Samuel","last_name":"Camenzind"},{"last_name":"De Kock","first_name":"Joery","full_name":"De Kock, Joery"},{"last_name":"Elezović","full_name":"Elezović, Alisa","first_name":"Alisa"},{"last_name":"Erden","full_name":"Erden, Sevilay","first_name":"Sevilay"},{"last_name":"Gonzalez-Uarquin","first_name":"Fernando","full_name":"Gonzalez-Uarquin, Fernando"},{"full_name":"Ulman, Yesim Isil","first_name":"Yesim Isil","last_name":"Ulman"},{"last_name":"Hoffmann","first_name":"Orsolya Ivett","full_name":"Hoffmann, Orsolya Ivett"},{"full_name":"Kitsara, Maria","first_name":"Maria","last_name":"Kitsara"},{"last_name":"Kostomitsopoulos","full_name":"Kostomitsopoulos, Nikolaos","first_name":"Nikolaos"},{"full_name":"Neuhaus, Winfried","first_name":"Winfried","last_name":"Neuhaus"},{"first_name":"Benoit","full_name":"Petit-Demouliere, Benoit","last_name":"Petit-Demouliere"},{"last_name":"Pollo","first_name":"Simone","full_name":"Pollo, Simone"},{"last_name":"Riso","first_name":"Brígida","full_name":"Riso, Brígida"},{"last_name":"Schober","id":"80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8","first_name":"Sophie","full_name":"Schober, Sophie"},{"full_name":"Sotiropoulos, Athanassia","first_name":"Athanassia","last_name":"Sotiropoulos"},{"last_name":"Thomas","full_name":"Thomas, Aurélie","first_name":"Aurélie"},{"last_name":"Vitale","first_name":"Augusto","full_name":"Vitale, Augusto"},{"last_name":"Wilflingseder","full_name":"Wilflingseder, Doris","first_name":"Doris"},{"last_name":"Ahluwalia","first_name":"Arti","full_name":"Ahluwalia, Arti"}],"publication_identifier":{"issn":["0093-7355"],"eissn":["1548-4475"]},"scopus_import":"1","day":"01","article_processing_charge":"No","type":"journal_article","ddc":["570"],"fulldoi":"https://doi.org/10.1038/s41684-024-01476-2","has_accepted_license":"1","date_published":"2024-12-01T00:00:00Z","pmid":1,"external_id":{"pmid":["39548348"],"isi":["001355264100001"]},"language":[{"iso":"eng"}]},{"quality_controlled":"1","publisher":"Springer Nature","status":"public","acknowledgement":"Financial support from the Netherlands Organization for Scientific Research (NWO-CW), the Dutch Ministry of Education, Culture and Science (Gravitation program No.024.001.035), the China Scholarship Council (CSC PhD Fellowship No.201808330459 to J. S.). We thank Dr. Youxin Fu, Dr. Alexander Ryabchun, Dr. Wojciech Danowski, Dr. Jianyu Zhang and Yahan Shan from University of Groningen for their help to this project and fruitful discussions.","abstract":[{"lang":"eng","text":"Light-driven rotary molecular motors are among the most promising classes of responsive molecular machines and take advantage of their intrinsic chirality which governs unidirectional rotation. As a consequence of their dynamic function, they receive considerable interest in the areas of supramolecular chemistry, asymmetric catalysis and responsive materials. Among the emerging classes of responsive photochromic molecules, multistate first-generation molecular motors driven by benign visible light remain unexplored, which limits the exploitation of the full potential of these mechanical light-powered systems. Herein, we describe a series of all-visible-light-driven first-generation molecular motors based on the salicylidene Schiff base functionality. Remarkable redshifts up to 100 nm in absorption are achieved compared to conventional first-generation motor structures. Taking advantage of all-visible-light-driven multistate motor scaffolds, adaptive behaviour is found as well, and potential application in multistate photoluminescence is demonstrated. These functional visible-light-responsive motors will likely stimulate the design and synthesis of more sophisticated nanomachinery with a myriad of future applications in powering dynamic systems."}],"title":"All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors","citation":{"short":"S. Van Vliet, J. Sheng, C.N. Stindt, B.L. Feringa, Nature Communications 15 (2024).","ieee":"S. Van Vliet, J. Sheng, C. N. Stindt, and B. L. Feringa, “All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors,” <i>Nature Communications</i>, vol. 15. Springer Nature, 2024.","chicago":"Van Vliet, Sven, Jinyu Sheng, Charlotte N. Stindt, and Ben L. Feringa. “All-Visible-Light-Driven Salicylidene Schiff-Base-Functionalized Artificial Molecular Motors.” <i>Nature Communications</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41467-024-50587-4\">https://doi.org/10.1038/s41467-024-50587-4</a>.","apa":"Van Vliet, S., Sheng, J., Stindt, C. N., &#38; Feringa, B. L. (2024). All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-024-50587-4\">https://doi.org/10.1038/s41467-024-50587-4</a>","ama":"Van Vliet S, Sheng J, Stindt CN, Feringa BL. All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors. <i>Nature Communications</i>. 2024;15. doi:<a href=\"https://doi.org/10.1038/s41467-024-50587-4\">10.1038/s41467-024-50587-4</a>","mla":"Van Vliet, Sven, et al. “All-Visible-Light-Driven Salicylidene Schiff-Base-Functionalized Artificial Molecular Motors.” <i>Nature Communications</i>, vol. 15, 6461, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1038/s41467-024-50587-4\">10.1038/s41467-024-50587-4</a>.","ista":"Van Vliet S, Sheng J, Stindt CN, Feringa BL. 2024. All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors. Nature Communications. 15, 6461."},"publication_status":"published","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":15,"year":"2024","researchdata_availability":"yes","doi":"10.1038/s41467-024-50587-4","oa_version":"Published Version","publication":"Nature Communications","intvolume":"        15","file_date_updated":"2024-08-12T08:23:10Z","das_tickbox":"1","oa":1,"isi":1,"date_updated":"2026-09-17T10:46:04Z","file":[{"content_type":"application/pdf","date_created":"2024-08-12T08:23:10Z","access_level":"open_access","relation":"main_file","file_size":1355696,"checksum":"4aca2ea30fe529947cb2f4c7fc2af2df","file_name":"2024_NatureComm_vanVliet.pdf","creator":"dernst","date_updated":"2024-08-12T08:23:10Z","file_id":"17418","success":1}],"date_created":"2024-08-11T22:01:11Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_type":"original","department":[{"_id":"RaKl"}],"DOAJ_listed":"1","_id":"17409","month":"07","dataavailabilitystatement":"Data that support the findings of this study are available within the Supplementary Information. All data are available from the corresponding author upon request. The XYZ coordinates of the DFT-optimized structures are available as source data. Source data are provided with this paper.","day":"31","type":"journal_article","article_processing_charge":"Yes","article_number":"6461","supplementarymaterial":"yes","scopus_import":"1","publication_identifier":{"eissn":["2041-1723"]},"author":[{"first_name":"Sven","full_name":"Van Vliet, Sven","last_name":"Van Vliet"},{"last_name":"Sheng","full_name":"Sheng, Jinyu","first_name":"Jinyu","id":"639f0526-27c9-11ee-95a6-966cd7f102d8"},{"first_name":"Charlotte N.","full_name":"Stindt, Charlotte N.","last_name":"Stindt"},{"last_name":"Feringa","full_name":"Feringa, Ben L.","first_name":"Ben L."}],"pmid":1,"external_id":{"pmid":["39085193"],"isi":["001282384300020"]},"date_published":"2024-07-31T00:00:00Z","language":[{"iso":"eng"}],"has_accepted_license":"1","fulldoi":"https://doi.org/10.1038/s41467-024-50587-4","ddc":["540"]},{"publisher":"Wiley","issue":"23","status":"public","quality_controlled":"1","abstract":[{"text":"The development of photoresponsive systems with non-invasive orthogonal control by distinct wavelengths of light is still in its infancy. In particular, the design of photochemically triggered-orthogonal systems integrated into solid materials that enable multiple dynamic control over their properties remains a longstanding challenge. Here, we report the orthogonal and reversible control of two types of photoswitches in an integrated solid porous framework, that is, visible-light responsive o-fluoroazobenzene and nitro-spiropyran motifs. The properties of the constructed material can be selectively controlled by different wavelengths of light thus generating four distinct states providing a basis for dynamic multifunctional materials. Solid-state NMR spectroscopy demonstrated the selective transformation of the azobenzene switch in the bulk, which in turn modulates N2 and CO2 adsorption.","lang":"eng"}],"title":"Orthogonal photoswitching in a porous organic framework","acknowledgement":"This work was supported from the following sources: China Scholarship Council (CSC PhD Fellowship No. 201808330459 to J.S.), the Ministry of Education, Culture and Science of the Netherlands (Gravitation Program No. 024.001.035 to BLF), Financial support from The Netherlands Organization for Scientific Research (NWO-CW), the European Research Council (ERC; advanced Grant No. 694345 to B.L.F.). PRIN (SHERPA 2020 No. H45F21003430001) and PRIN (HySTAR 2022 No. H53D23004720006) and Lombardy Region for “Enhancing Photosynthesis” grant (2021-2023 No. H45F21002830007). W.D. is grateful for financial support from Marie Skłodowska-Curie Actions (Individual Fellowship No. 101027639). P.C. is grateful for the financial support provided by the PRELUDIUM grant from the National Science Center Poland (Reg. No: 2023/49/N/ST5/01864).","year":"2024","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":63,"researchdata_availability":"yes","publication_status":"published","citation":{"ista":"Sheng J, Perego J, Bracco S, Cieciórski P, Danowski W, Comotti A, Feringa BL. 2024. Orthogonal photoswitching in a porous organic framework. Angewandte Chemie International Edition. 63(23), e202404878.","mla":"Sheng, Jinyu, et al. “Orthogonal Photoswitching in a Porous Organic Framework.” <i>Angewandte Chemie International Edition</i>, vol. 63, no. 23, e202404878, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/anie.202404878\">10.1002/anie.202404878</a>.","ama":"Sheng J, Perego J, Bracco S, et al. Orthogonal photoswitching in a porous organic framework. <i>Angewandte Chemie International Edition</i>. 2024;63(23). doi:<a href=\"https://doi.org/10.1002/anie.202404878\">10.1002/anie.202404878</a>","apa":"Sheng, J., Perego, J., Bracco, S., Cieciórski, P., Danowski, W., Comotti, A., &#38; Feringa, B. L. (2024). Orthogonal photoswitching in a porous organic framework. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.202404878\">https://doi.org/10.1002/anie.202404878</a>","chicago":"Sheng, Jinyu, Jacopo Perego, Silvia Bracco, Piotr Cieciórski, Wojciech Danowski, Angiolina Comotti, and Ben L. Feringa. “Orthogonal Photoswitching in a Porous Organic Framework.” <i>Angewandte Chemie International Edition</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/anie.202404878\">https://doi.org/10.1002/anie.202404878</a>.","ieee":"J. Sheng <i>et al.</i>, “Orthogonal photoswitching in a porous organic framework,” <i>Angewandte Chemie International Edition</i>, vol. 63, no. 23. Wiley, 2024.","short":"J. Sheng, J. Perego, S. Bracco, P. Cieciórski, W. Danowski, A. Comotti, B.L. Feringa, Angewandte Chemie International Edition 63 (2024)."},"doi":"10.1002/anie.202404878","intvolume":"        63","file_date_updated":"2024-06-03T10:33:17Z","oa_version":"Published Version","publication":"Angewandte Chemie International Edition","oa":1,"date_updated":"2026-09-17T10:32:51Z","file":[{"file_id":"17107","date_updated":"2024-06-03T10:33:17Z","success":1,"creator":"dernst","file_name":"2024_AngChemieInt_Sheng.pdf","relation":"main_file","checksum":"7ecb0892051f6ed8f6a6f25baa47543a","file_size":2363206,"content_type":"application/pdf","date_created":"2024-06-03T10:33:17Z","access_level":"open_access"}],"das_tickbox":"1","article_type":"original","department":[{"_id":"RaKl"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-06-03T09:00:01Z","month":"03","dataavailabilitystatement":"The data that support the findings of this study are available in the supplementary material of this article.","_id":"17105","day":"26","article_processing_charge":"Yes (in subscription journal)","type":"journal_article","supplementarymaterial":"yes","article_number":"e202404878","author":[{"id":"639f0526-27c9-11ee-95a6-966cd7f102d8","first_name":"Jinyu","full_name":"Sheng, Jinyu","last_name":"Sheng"},{"full_name":"Perego, Jacopo","first_name":"Jacopo","last_name":"Perego"},{"last_name":"Bracco","full_name":"Bracco, Silvia","first_name":"Silvia"},{"last_name":"Cieciórski","first_name":"Piotr","full_name":"Cieciórski, Piotr"},{"full_name":"Danowski, Wojciech","first_name":"Wojciech","last_name":"Danowski"},{"first_name":"Angiolina","full_name":"Comotti, Angiolina","last_name":"Comotti"},{"last_name":"Feringa","full_name":"Feringa, Ben L.","first_name":"Ben L."}],"scopus_import":"1","publication_identifier":{"eissn":["1521-3773"],"issn":["1433-7851"]},"pmid":1,"external_id":{"pmid":["38530132"]},"date_published":"2024-03-26T00:00:00Z","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1002/anie.202404878","ddc":["540"],"has_accepted_license":"1"},{"date_updated":"2026-09-17T11:01:40Z","file":[{"date_updated":"2025-01-09T09:38:51Z","file_id":"18804","success":1,"creator":"dernst","file_name":"2024_Aggregate_Shan.pdf","checksum":"1e79dc81d0edf0b441ef661a1890bbf5","file_size":2299084,"relation":"main_file","access_level":"open_access","content_type":"application/pdf","date_created":"2025-01-09T09:38:51Z"}],"oa":1,"das_tickbox":"0","file_date_updated":"2025-01-09T09:38:51Z","intvolume":"         5","oa_version":"Published Version","publication":"Aggregate","month":"10","_id":"17054","department":[{"_id":"RaKl"}],"article_type":"original","date_created":"2024-05-26T22:00:58Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","abstract":[{"lang":"eng","text":"Photoisomerization and photoluminescence are two distinct energy dissipation pathways in light-driven molecular motors. The photoisomerization properties of discrete molecular motors have been well established in solution, but their photoluminescent properties have been rarely reported—especially in aggregates. Here, it is shown that an overcrowded alkene-based molecular motor exhibits distinct dynamic properties in solution and aggregate states, for example, gel and solid states. Despite the poor emissive properties of molecular motors in solution, a bright emission is observed in the aggregate states, including in gel and the crystalline solid. The emission wavelength is highly dependent on the nature of the supramolecular packing and order in the aggregates. As a result, the fluorescent color can be readily tuned reversibly via mechanical grinding and vapor fuming, which provides a new platform for developing multi-stimuli functional materials."}],"title":"Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates","acknowledgement":"This work was supported by the National Natural Science Foundation of China (grant nos. 22220102004, 22025503), Shanghai Municipal Science and Technology Major Project (grant no. 2018SHZDZX03), the Innovation Program of Shanghai Municipal Education Commission (2023ZKZD40), the Fundamental Research Funds for the Central Universities, the Program of Introducing Talents of Discipline to Universities (grant no. B16017), Science and Technology Commission of Shanghai Municipality (grant no. 21JC1401700), and the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study (grant no. SN-ZJU-SIAS-006), China Scholarship Council (CSC PhD Fellowship No. 202006745016 to Yahan Shan). The authors gratefully acknowledge financial support from the Dutch Ministry of Education, Culture and Science (gravitation program no. 024.001.035 to Ben L. Feringa). The authors thank Dr. Youxin Fu and Dr. Alexander Ryabchun for the help with fluorescence quantum yield measurement, Cristina Nitu for the help with photoisomerzation quantum yield measurement, Prof. Wesley R. Browne for the help with fluorescence lifetime measurement, and Dr. Jianyu Zhang for fruitful discussion and revising the manuscript.","status":"public","issue":"5","publisher":"Wiley","quality_controlled":"1","OA_type":"gold","doi":"10.1002/agt2.584","volume":5,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2024","researchdata_availability":"no","publication_status":"published","citation":{"ieee":"Y. Shan, J. Sheng, Q. Zhang, M. C. A. Stuart, D. H. Qu, and B. L. Feringa, “Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates,” <i>Aggregate</i>, vol. 5, no. 5. Wiley, 2024.","short":"Y. Shan, J. Sheng, Q. Zhang, M.C.A. Stuart, D.H. Qu, B.L. Feringa, Aggregate 5 (2024).","apa":"Shan, Y., Sheng, J., Zhang, Q., Stuart, M. C. A., Qu, D. H., &#38; Feringa, B. L. (2024). Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates. <i>Aggregate</i>. Wiley. <a href=\"https://doi.org/10.1002/agt2.584\">https://doi.org/10.1002/agt2.584</a>","chicago":"Shan, Yahan, Jinyu Sheng, Qi Zhang, Marc C.A. Stuart, Da Hui Qu, and Ben L. Feringa. “Multi-State Photoluminescent Properties of an Overcrowded Alkene-Based Molecular Motor in Aggregates.” <i>Aggregate</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/agt2.584\">https://doi.org/10.1002/agt2.584</a>.","mla":"Shan, Yahan, et al. “Multi-State Photoluminescent Properties of an Overcrowded Alkene-Based Molecular Motor in Aggregates.” <i>Aggregate</i>, vol. 5, no. 5, e584, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/agt2.584\">10.1002/agt2.584</a>.","ama":"Shan Y, Sheng J, Zhang Q, Stuart MCA, Qu DH, Feringa BL. Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates. <i>Aggregate</i>. 2024;5(5). doi:<a href=\"https://doi.org/10.1002/agt2.584\">10.1002/agt2.584</a>","ista":"Shan Y, Sheng J, Zhang Q, Stuart MCA, Qu DH, Feringa BL. 2024. Multi-state photoluminescent properties of an overcrowded alkene-based molecular motor in aggregates. Aggregate. 5(5), e584."},"OA_place":"publisher","language":[{"iso":"eng"}],"date_published":"2024-10-01T00:00:00Z","ddc":["540"],"fulldoi":"https://doi.org/10.1002/agt2.584","has_accepted_license":"1","article_processing_charge":"Yes","type":"journal_article","day":"01","author":[{"last_name":"Shan","full_name":"Shan, Yahan","first_name":"Yahan"},{"last_name":"Sheng","id":"639f0526-27c9-11ee-95a6-966cd7f102d8","first_name":"Jinyu","full_name":"Sheng, Jinyu"},{"full_name":"Zhang, Qi","first_name":"Qi","last_name":"Zhang"},{"last_name":"Stuart","first_name":"Marc C.A.","full_name":"Stuart, Marc C.A."},{"last_name":"Qu","full_name":"Qu, Da Hui","first_name":"Da Hui"},{"last_name":"Feringa","first_name":"Ben L.","full_name":"Feringa, Ben L."}],"publication_identifier":{"eissn":["2692-4560"],"issn":["2766-8541"]},"scopus_import":"1","supplementarymaterial":"yes","article_number":"e584"},{"issue":"6","status":"public","publisher":"SAGE Publications","quality_controlled":"1","title":"Introducing the COST action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)","year":"2024","volume":52,"researchdata_availability":"no","citation":{"apa":"Kitsara, M., Smajlhodžić-Deljo, M., Gurbeta Pokvic, L., Bert, B., Bubalo, N., Erden, S., … Neuhaus, W. 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Gurbeta Pokvic, B. Bert, N. Bubalo, S. Erden, N.H. Franco, G. Chirico, J. Gómez Raja, F. Gonzalez-Uarquin, A. Lang, N. Linklater, S. Mojsova, I.A.S. Olsson, I. Sandvig, A. Schaffert, M. Schmit, S. Schober, B. Sevastre, D. Wilflingseder, A. Ahluwalia, W. Neuhaus, Alternatives to Laboratory Animals 52 (2024) 326–333.","ista":"Kitsara M, Smajlhodžić-Deljo M, Gurbeta Pokvic L, Bert B, Bubalo N, Erden S, Franco NH, Chirico G, Gómez Raja J, Gonzalez-Uarquin F, Lang A, Linklater N, Mojsova S, Olsson IAS, Sandvig I, Schaffert A, Schmit M, Schober S, Sevastre B, Wilflingseder D, Ahluwalia A, Neuhaus W. 2024. Introducing the COST action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE). 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Introducing the COST action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE). <i>Alternatives to Laboratory Animals</i>. 2024;52(6):326-333. doi:<a href=\"https://doi.org/10.1177/02611929241286024\">10.1177/02611929241286024</a>"},"publication_status":"published","OA_type":"closed access","doi":"10.1177/02611929241286024","intvolume":"        52","oa_version":"None","publication":"Alternatives to Laboratory Animals","isi":1,"date_updated":"2026-09-17T10:30:08Z","das_tickbox":"0","department":[{"_id":"PreCl"}],"article_type":"original","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-10-13T22:01:51Z","month":"11","_id":"18310","day":"01","article_processing_charge":"No","type":"journal_article","supplementarymaterial":"no","page":"326-333","author":[{"last_name":"Kitsara","first_name":"Maria","full_name":"Kitsara, Maria"},{"first_name":"Merima","full_name":"Smajlhodžić-Deljo, Merima","last_name":"Smajlhodžić-Deljo"},{"last_name":"Gurbeta Pokvic","first_name":"Lejla","full_name":"Gurbeta Pokvic, Lejla"},{"last_name":"Bert","first_name":"Bettina","full_name":"Bert, Bettina"},{"last_name":"Bubalo","full_name":"Bubalo, Nataliia","first_name":"Nataliia"},{"full_name":"Erden, Sevilay","first_name":"Sevilay","last_name":"Erden"},{"first_name":"Nuno Henrique","full_name":"Franco, Nuno Henrique","last_name":"Franco"},{"full_name":"Chirico, Giuseppe","first_name":"Giuseppe","last_name":"Chirico"},{"last_name":"Gómez Raja","full_name":"Gómez Raja, Jonathan","first_name":"Jonathan"},{"first_name":"Fernando","full_name":"Gonzalez-Uarquin, Fernando","last_name":"Gonzalez-Uarquin"},{"last_name":"Lang","first_name":"Annemarie","full_name":"Lang, Annemarie"},{"last_name":"Linklater","full_name":"Linklater, Nicole","first_name":"Nicole"},{"last_name":"Mojsova","full_name":"Mojsova, Sandra","first_name":"Sandra"},{"first_name":"I. Anna S.","full_name":"Olsson, I. Anna S.","last_name":"Olsson"},{"first_name":"Ioanna","full_name":"Sandvig, Ioanna","last_name":"Sandvig"},{"last_name":"Schaffert","full_name":"Schaffert, Alexandra","first_name":"Alexandra"},{"full_name":"Schmit, Marthe","first_name":"Marthe","last_name":"Schmit"},{"first_name":"Sophie","id":"80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8","full_name":"Schober, Sophie","last_name":"Schober"},{"last_name":"Sevastre","full_name":"Sevastre, Bogdan","first_name":"Bogdan"},{"first_name":"Doris","full_name":"Wilflingseder, Doris","last_name":"Wilflingseder"},{"full_name":"Ahluwalia, Arti","first_name":"Arti","last_name":"Ahluwalia"},{"first_name":"Winfried","full_name":"Neuhaus, Winfried","last_name":"Neuhaus"}],"scopus_import":"1","publication_identifier":{"eissn":["2632-3559"],"issn":["0261-1929"]},"date_published":"2024-11-01T00:00:00Z","pmid":1,"external_id":{"pmid":["39333027"],"isi":["001348633700007"]},"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1177/02611929241286024"},{"language":[{"iso":"eng"}],"arxiv":1,"date_published":"2024-04-06T00:00:00Z","external_id":{"arxiv":["2307.13115"],"isi":["001197663100002"]},"ddc":["510"],"fulldoi":"https://doi.org/10.1007/s10955-024-03260-5","has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","type":"journal_article","day":"06","author":[{"last_name":"Bossmann","orcid":"0000-0002-6854-1343","first_name":"Lea","id":"A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425","full_name":"Bossmann, Lea"},{"full_name":"Leopold, Nikolai K","id":"4BC40BEC-F248-11E8-B48F-1D18A9856A87","first_name":"Nikolai K","last_name":"Leopold","orcid":"0000-0002-0495-6822"},{"last_name":"Mitrouskas","id":"cbddacee-2b11-11eb-a02e-a2e14d04e52d","first_name":"David Johannes","full_name":"Mitrouskas, David Johannes"},{"full_name":"Petrat, Sören P","first_name":"Sören P","id":"40AC02DC-F248-11E8-B48F-1D18A9856A87","last_name":"Petrat","orcid":"0000-0002-9166-5889"}],"publication_identifier":{"eissn":["1572-9613"],"issn":["0022-4715"]},"scopus_import":"1","supplementarymaterial":"no","article_number":"48","file":[{"file_name":"2024_JourStatPhysics_Bossmann.pdf","creator":"dernst","success":1,"date_updated":"2024-04-16T11:09:37Z","file_id":"15325","access_level":"open_access","date_created":"2024-04-16T11:09:37Z","content_type":"application/pdf","checksum":"839242a9ec1c01158112de25f196e60d","file_size":398665,"relation":"main_file"}],"isi":1,"date_updated":"2026-09-17T11:05:18Z","oa":1,"das_tickbox":"1","file_date_updated":"2024-04-16T11:09:37Z","intvolume":"       191","publication":"Journal of Statistical Physics","oa_version":"Published Version","dataavailabilitystatement":"Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.","month":"04","_id":"15318","department":[{"_id":"RoSe"}],"article_type":"original","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-04-14T22:01:02Z","title":"A note on the binding energy for Bosons in the mean-field limit","abstract":[{"lang":"eng","text":"We consider a gas of N weakly interacting bosons in the ground state. Such gases exhibit Bose–Einstein condensation. The binding energy is defined as the energy it takes to remove one particle from the gas. In this article, we prove an asymptotic expansion for the binding energy, and compute the first orders explicitly for the homogeneous gas. Our result addresses in particular a conjecture by Nam (Lett Math Phys 108(1):141–159, 2018), and provides an asymptotic expansion of the ionization energy of bosonic atoms."}],"acknowledgement":"It is a pleasure to thank Phan Thành Nam for helpful discussions on bosonic atoms. L.B. was supported by the German Research Foundation within the Munich Center of Quantum Science and Technology (EXC 2111). N.L. gratefully acknowledges support from the Swiss National Science Foundation through the NCCR SwissMap and funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant agreement No 101024712. S.P. acknowledges funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project number 512258249.\r\nOpen Access funding enabled and organized by Projekt DEAL.","status":"public","issue":"4","publisher":"Springer Nature","quality_controlled":"1","doi":"10.1007/s10955-024-03260-5","researchdata_availability":"not applicable","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":191,"year":"2024","citation":{"ama":"Bossmann L, Leopold NK, Mitrouskas DJ, Petrat SP. A note on the binding energy for Bosons in the mean-field limit. <i>Journal of Statistical Physics</i>. 2024;191(4). doi:<a href=\"https://doi.org/10.1007/s10955-024-03260-5\">10.1007/s10955-024-03260-5</a>","mla":"Bossmann, Lea, et al. “A Note on the Binding Energy for Bosons in the Mean-Field Limit.” <i>Journal of Statistical Physics</i>, vol. 191, no. 4, 48, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1007/s10955-024-03260-5\">10.1007/s10955-024-03260-5</a>.","ista":"Bossmann L, Leopold NK, Mitrouskas DJ, Petrat SP. 2024. A note on the binding energy for Bosons in the mean-field limit. Journal of Statistical Physics. 191(4), 48.","short":"L. Bossmann, N.K. Leopold, D.J. Mitrouskas, S.P. Petrat, Journal of Statistical Physics 191 (2024).","ieee":"L. Bossmann, N. K. Leopold, D. J. Mitrouskas, and S. P. Petrat, “A note on the binding energy for Bosons in the mean-field limit,” <i>Journal of Statistical Physics</i>, vol. 191, no. 4. Springer Nature, 2024.","chicago":"Bossmann, Lea, Nikolai K Leopold, David Johannes Mitrouskas, and Sören P Petrat. “A Note on the Binding Energy for Bosons in the Mean-Field Limit.” <i>Journal of Statistical Physics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s10955-024-03260-5\">https://doi.org/10.1007/s10955-024-03260-5</a>.","apa":"Bossmann, L., Leopold, N. K., Mitrouskas, D. J., &#38; Petrat, S. P. (2024). A note on the binding energy for Bosons in the mean-field limit. <i>Journal of Statistical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10955-024-03260-5\">https://doi.org/10.1007/s10955-024-03260-5</a>"},"publication_status":"published"},{"title":"The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass","abstract":[{"lang":"eng","text":"We study the Fröhlich polaron model in R3, and prove a lower bound on its ground state energy as a function of the total momentum. The bound is asymptotically sharp at large coupling. In combination with a corresponding upper bound proved earlier (Mitrouskas et al. in Forum Math. Sigma 11:1–52, 2023), it shows that the energy is approximately parabolic below the continuum threshold, and that the polaron’s effective mass (defined as the semi-latus rectum of the\r\nparabola) is given by the celebrated Landau–Pekar formula. In particular, it diverges as α4 for large coupling constant α."}],"quality_controlled":"1","status":"public","publisher":"Springer Nature","doi":"10.1007/s10240-024-00150-0","OA_type":"hybrid","publication_status":"published","OA_place":"publisher","citation":{"chicago":"Brooks, Morris, and Robert Seiringer. “The Fröhlich Polaron at Strong Coupling: Part II — Energy-Momentum Relation and Effective Mass.” <i>Publications Mathematiques de l’Institut Des Hautes Etudes Scientifiques</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s10240-024-00150-0\">https://doi.org/10.1007/s10240-024-00150-0</a>.","apa":"Brooks, M., &#38; Seiringer, R. (2024). The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass. <i>Publications Mathematiques de l’Institut Des Hautes Etudes Scientifiques</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10240-024-00150-0\">https://doi.org/10.1007/s10240-024-00150-0</a>","short":"M. Brooks, R. Seiringer, Publications Mathematiques de l’Institut Des Hautes Etudes Scientifiques 140 (2024) 271–309.","ieee":"M. Brooks and R. Seiringer, “The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass,” <i>Publications Mathematiques de l’Institut des Hautes Etudes Scientifiques</i>, vol. 140. Springer Nature, pp. 271–309, 2024.","ista":"Brooks M, Seiringer R. 2024. The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass. Publications Mathematiques de l’Institut des Hautes Etudes Scientifiques. 140, 271–309.","ama":"Brooks M, Seiringer R. The Fröhlich polaron at strong coupling: Part II — Energy-momentum relation and effective mass. <i>Publications Mathematiques de l’Institut des Hautes Etudes Scientifiques</i>. 2024;140:271-309. doi:<a href=\"https://doi.org/10.1007/s10240-024-00150-0\">10.1007/s10240-024-00150-0</a>","mla":"Brooks, Morris, and Robert Seiringer. “The Fröhlich Polaron at Strong Coupling: Part II — Energy-Momentum Relation and Effective Mass.” <i>Publications Mathematiques de l’Institut Des Hautes Etudes Scientifiques</i>, vol. 140, Springer Nature, 2024, pp. 271–309, doi:<a href=\"https://doi.org/10.1007/s10240-024-00150-0\">10.1007/s10240-024-00150-0</a>."},"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"researchdata_availability":"no","year":"2024","volume":140,"das_tickbox":"0","isi":1,"date_updated":"2026-09-17T11:07:19Z","file":[{"content_type":"application/pdf","date_created":"2025-01-13T08:13:42Z","access_level":"open_access","relation":"main_file","checksum":"af3becc50f7534c9409d3ff8b5c47ed6","file_size":924342,"creator":"dernst","file_name":"2024_PublicMathIHES_Brooks.pdf","date_updated":"2025-01-13T08:13:42Z","file_id":"18824","success":1}],"oa":1,"oa_version":"Published Version","publication":"Publications Mathematiques de l'Institut des Hautes Etudes Scientifiques","file_date_updated":"2025-01-13T08:13:42Z","intvolume":"       140","_id":"17478","month":"12","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-09-01T22:01:08Z","department":[{"_id":"RoSe"}],"article_type":"original","type":"journal_article","article_processing_charge":"Yes (in subscription journal)","day":"01","scopus_import":"1","publication_identifier":{"eissn":["1618-1913"],"issn":["0073-8301"]},"author":[{"full_name":"Brooks, Morris","id":"B7ECF9FC-AA38-11E9-AC9A-0930E6697425","first_name":"Morris","last_name":"Brooks","orcid":"0000-0002-6249-0928"},{"id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer"}],"page":"271-309","corr_author":"1","supplementarymaterial":"yes","language":[{"iso":"eng"}],"external_id":{"isi":["001297785000001"],"arxiv":["2211.03353"]},"date_published":"2024-12-01T00:00:00Z","arxiv":1,"has_accepted_license":"1","ddc":["510"],"fulldoi":"https://doi.org/10.1007/s10240-024-00150-0"},{"das_tickbox":"0","date_updated":"2026-09-17T11:08:01Z","oa":1,"oa_version":"Preprint","publication":"Physics and the Nature of Reality","intvolume":"       215","editor":[{"last_name":"Bassi","first_name":"Angelo","full_name":"Bassi, Angelo"},{"first_name":"Sheldon","full_name":"Goldstein, Sheldon","last_name":"Goldstein"},{"last_name":"Tumulka","first_name":"Roderich","full_name":"Tumulka, Roderich"},{"full_name":"Zanghi, Nino","first_name":"Nino","last_name":"Zanghi"}],"_id":"18948","month":"02","date_created":"2025-01-29T10:30:08Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"RoSe"}],"acknowledgement":"It is our pleasure to thank Marco Falconi, Nataša Pavlović, Peter Pickl, Robert Seiringer and Avy Soffer for the collaboration on the works [11, 13, 14, 21, 33, 39]. L.B. was supported by the German Research Foundation within the Munich Center of Quantum Science and Technology (EXC 2111). N.L. acknowledges support from the Swiss National Science Foundation through the NCCR SwissMap and funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101024712. S.P. acknowledges funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - project number 512258249.","abstract":[{"text":"We consider a gas of N bosons with interactions in the mean-field scaling regime. We review a recent proof of the asymptotic expansion of its spectrum and eigenstates and two applications of this result, namely the derivation of an Edgeworth expansion for fluctuations of one-body operators and the computation of the binding energy of an inhomogeneous Bose gas to any order. Finally, we collect related results for the dynamics of the weakly interacting Bose gas and for the regularized Nelson model.","lang":"eng"}],"title":"Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications","quality_controlled":"1","status":"public","publisher":"Springer Nature","series_title":"FTPH","doi":"10.1007/978-3-031-45434-9_22","OA_type":"green","OA_place":"repository","citation":{"ama":"Bossmann L, Leopold N, Mitrouskas DJ, Petrat S. Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications. In: Bassi A, Goldstein S, Tumulka R, Zanghi N, eds. <i>Physics and the Nature of Reality</i>. Vol 215. FTPH. Cham: Springer Nature; 2024:307-321. doi:<a href=\"https://doi.org/10.1007/978-3-031-45434-9_22\">10.1007/978-3-031-45434-9_22</a>","mla":"Bossmann, Lea, et al. “Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications.” <i>Physics and the Nature of Reality</i>, edited by Angelo Bassi et al., vol. 215, Springer Nature, 2024, pp. 307–21, doi:<a href=\"https://doi.org/10.1007/978-3-031-45434-9_22\">10.1007/978-3-031-45434-9_22</a>.","ista":"Bossmann L, Leopold N, Mitrouskas DJ, Petrat S. 2024.Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications. In: Physics and the Nature of Reality. Fundamental Theories of Physics, vol. 215, 307–321.","short":"L. Bossmann, N. Leopold, D.J. Mitrouskas, S. Petrat, in:, A. Bassi, S. Goldstein, R. Tumulka, N. Zanghi (Eds.), Physics and the Nature of Reality, Springer Nature, Cham, 2024, pp. 307–321.","ieee":"L. Bossmann, N. Leopold, D. J. Mitrouskas, and S. Petrat, “Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications,” in <i>Physics and the Nature of Reality</i>, vol. 215, A. Bassi, S. Goldstein, R. Tumulka, and N. Zanghi, Eds. Cham: Springer Nature, 2024, pp. 307–321.","chicago":"Bossmann, Lea, Nikolai Leopold, David Johannes Mitrouskas, and Sören Petrat. “Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications.” In <i>Physics and the Nature of Reality</i>, edited by Angelo Bassi, Sheldon Goldstein, Roderich Tumulka, and Nino Zanghi, 215:307–21. FTPH. Cham: Springer Nature, 2024. <a href=\"https://doi.org/10.1007/978-3-031-45434-9_22\">https://doi.org/10.1007/978-3-031-45434-9_22</a>.","apa":"Bossmann, L., Leopold, N., Mitrouskas, D. J., &#38; Petrat, S. (2024). Asymptotic Analysis of the Weakly Interacting Bose Gas: A Collection of Recent Results and Applications. In A. Bassi, S. Goldstein, R. Tumulka, &#38; N. Zanghi (Eds.), <i>Physics and the Nature of Reality</i> (Vol. 215, pp. 307–321). Cham: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-45434-9_22\">https://doi.org/10.1007/978-3-031-45434-9_22</a>"},"publication_status":"published","volume":215,"year":"2024","researchdata_availability":"no","language":[{"iso":"eng"}],"external_id":{"arxiv":["2304.12910"]},"alternative_title":["Fundamental Theories of Physics"],"date_published":"2024-02-04T00:00:00Z","arxiv":1,"fulldoi":"https://doi.org/10.1007/978-3-031-45434-9_22","type":"book_chapter","article_processing_charge":"No","place":"Cham","day":"04","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2304.12910","open_access":"1"}],"publication_identifier":{"issn":["0168-1222"],"isbn":["9783031454332"],"eissn":["2365-6425"],"eisbn":["9783031454349"]},"scopus_import":"1","author":[{"id":"A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425","first_name":"Lea","full_name":"Bossmann, Lea","orcid":"0000-0002-6854-1343","last_name":"Bossmann"},{"first_name":"Nikolai","full_name":"Leopold, Nikolai","last_name":"Leopold"},{"full_name":"Mitrouskas, David Johannes","id":"cbddacee-2b11-11eb-a02e-a2e14d04e52d","first_name":"David Johannes","last_name":"Mitrouskas"},{"last_name":"Petrat","full_name":"Petrat, Sören","first_name":"Sören"}],"page":"307-321","supplementarymaterial":"no"},{"related_material":{"link":[{"relation":"earlier_version","url":"https://doi.org/10.1101/2023.10.04.560631"}]},"das_tickbox":"1","file":[{"success":1,"date_updated":"2025-01-09T13:42:42Z","file_id":"18815","file_name":"2024_NeurologyNeuroimmNeuroinflamm_RitzauJost.pdf","creator":"dernst","relation":"main_file","checksum":"1e6d1230e0387f72752e3268f5330c9e","file_size":855818,"date_created":"2025-01-09T13:42:42Z","content_type":"application/pdf","access_level":"open_access"}],"isi":1,"date_updated":"2026-09-17T11:27:41Z","oa":1,"oa_version":"Published Version","publication":"Neurology, Neuroimmunology & Neuroinflammation","file_date_updated":"2025-01-09T13:42:42Z","intvolume":"        11","_id":"17457","DOAJ_listed":"1","dataavailabilitystatement":"Data that support the findings of this study are available from the corresponding author on reasonable request.","month":"09","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2024-08-25T22:01:07Z","department":[{"_id":"RySh"}],"article_type":"original","acknowledgement":"The authors thank Claudia Sommer for expert technical assistance, the Electron Microscopy Facility of IST-Austria for resources, and Tereza Belinova in the Imaging and Optics Facility of IST-Austria for 3D reconstruction. ","title":"LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening","abstract":[{"text":"Autoantibodies against the protein leucine-rich glioma inactivated 1 (LGI1) cause the most\r\ncommon subtype of autoimmune encephalitis with predominant involvement of the limbic\r\nsystem, associated with seizures and memory deficits. LGI1 and its receptor ADAM22 are part\r\nof a transsynaptic protein complex that includes several proteins involved in presynaptic\r\nneurotransmitter release and postsynaptic glutamate sensing. Autoantibodies against LGI1\r\nincrease excitatory synaptic strength, but studies that genetically disrupt the LGI1-ADAM22\r\ncomplex report a reduction in postsynaptic glutamate receptor-mediated responses. Thus, the\r\nmechanisms underlying the increased synaptic strength induced by LGI1 autoantibodies remain elusive, and the contributions of presynaptic molecules to the LGI1-transsynaptic complex remain unclear. We therefore investigated the presynaptic mechanisms that mediate\r\nautoantibody-induced synaptic strengthening.","lang":"eng"}],"quality_controlled":"1","issue":"5","status":"public","publisher":"Wolters Kluwer","project":[{"name":"LGI1 antibody-induced pathophysiology in synapses","grant_number":"I04638","_id":"05970B30-7A3F-11EA-A408-12923DDC885E"}],"doi":"10.1212/NXI.0000000000200284","OA_type":"gold","OA_place":"publisher","citation":{"apa":"Ritzau-Jost, A., Gsell, F., Sell, J., Sachs, S., Montanaro-Punzengruber, J.-C., Kirmann, T., … Hallermann, S. (2024). LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening. <i>Neurology, Neuroimmunology &#38; Neuroinflammation</i>. Wolters Kluwer. <a href=\"https://doi.org/10.1212/NXI.0000000000200284\">https://doi.org/10.1212/NXI.0000000000200284</a>","chicago":"Ritzau-Jost, Andreas, Felix Gsell, Josefine Sell, Stefan Sachs, Jacqueline-Claire Montanaro-Punzengruber, Toni Kirmann, Sebastian Maaß, et al. “LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic Kv1 Loss and Increased Action Potential Broadening.” <i>Neurology, Neuroimmunology &#38; Neuroinflammation</i>. Wolters Kluwer, 2024. <a href=\"https://doi.org/10.1212/NXI.0000000000200284\">https://doi.org/10.1212/NXI.0000000000200284</a>.","ieee":"A. Ritzau-Jost <i>et al.</i>, “LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening,” <i>Neurology, Neuroimmunology &#38; Neuroinflammation</i>, vol. 11, no. 5. Wolters Kluwer, p. e200284, 2024.","short":"A. Ritzau-Jost, F. Gsell, J. Sell, S. Sachs, J.-C. Montanaro-Punzengruber, T. Kirmann, S. Maaß, S.R. Irani, C. Werner, C. Geis, M. Sauer, R. Shigemoto, S. Hallermann, Neurology, Neuroimmunology &#38; Neuroinflammation 11 (2024) e200284.","ista":"Ritzau-Jost A, Gsell F, Sell J, Sachs S, Montanaro-Punzengruber J-C, Kirmann T, Maaß S, Irani SR, Werner C, Geis C, Sauer M, Shigemoto R, Hallermann S. 2024. LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening. Neurology, Neuroimmunology &#38; Neuroinflammation. 11(5), e200284.","mla":"Ritzau-Jost, Andreas, et al. “LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic Kv1 Loss and Increased Action Potential Broadening.” <i>Neurology, Neuroimmunology &#38; Neuroinflammation</i>, vol. 11, no. 5, Wolters Kluwer, 2024, p. e200284, doi:<a href=\"https://doi.org/10.1212/NXI.0000000000200284\">10.1212/NXI.0000000000200284</a>.","ama":"Ritzau-Jost A, Gsell F, Sell J, et al. LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening. <i>Neurology, Neuroimmunology &#38; Neuroinflammation</i>. 2024;11(5):e200284. doi:<a href=\"https://doi.org/10.1212/NXI.0000000000200284\">10.1212/NXI.0000000000200284</a>"},"publication_status":"published","volume":11,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"researchdata_availability":"upon request","year":"2024","language":[{"iso":"eng"}],"pmid":1,"date_published":"2024-09-01T00:00:00Z","external_id":{"isi":["001291908600001"],"pmid":["39141878"]},"has_accepted_license":"1","ddc":["570"],"fulldoi":"https://doi.org/10.1212/NXI.0000000000200284","type":"journal_article","acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"}],"article_processing_charge":"Yes","day":"01","publication_identifier":{"eissn":["2332-7812"]},"scopus_import":"1","author":[{"last_name":"Ritzau-Jost","full_name":"Ritzau-Jost, Andreas","first_name":"Andreas"},{"full_name":"Gsell, Felix","first_name":"Felix","last_name":"Gsell"},{"first_name":"Josefine","full_name":"Sell, Josefine","last_name":"Sell"},{"full_name":"Sachs, Stefan","first_name":"Stefan","last_name":"Sachs"},{"last_name":"Montanaro-Punzengruber","id":"3786AB44-F248-11E8-B48F-1D18A9856A87","first_name":"Jacqueline-Claire","full_name":"Montanaro-Punzengruber, Jacqueline-Claire"},{"last_name":"Kirmann","full_name":"Kirmann, Toni","first_name":"Toni"},{"last_name":"Maaß","first_name":"Sebastian","full_name":"Maaß, Sebastian"},{"full_name":"Irani, Sarosh R.","first_name":"Sarosh R.","last_name":"Irani"},{"last_name":"Werner","full_name":"Werner, Christian","first_name":"Christian"},{"last_name":"Geis","first_name":"Christian","full_name":"Geis, Christian"},{"last_name":"Sauer","full_name":"Sauer, Markus","first_name":"Markus"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"},{"first_name":"Stefan","full_name":"Hallermann, Stefan","last_name":"Hallermann"}],"page":"e200284","supplementarymaterial":"yes"},{"fulldoi":"https://doi.org/10.4171/owr/2023/39","language":[{"iso":"eng"}],"date_published":"2024-04-18T00:00:00Z","author":[{"last_name":"Hainzl","full_name":"Hainzl, Christian","first_name":"Christian"},{"last_name":"Schlein","full_name":"Schlein, Benjamin","first_name":"Benjamin"},{"last_name":"Seiringer","orcid":"0000-0002-6781-0521","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Seiringer, Robert"},{"full_name":"Warzel, Simone","first_name":"Simone","last_name":"Warzel"}],"publication_identifier":{"issn":["1660-8933"],"eissn":["1660-8941"]},"supplementarymaterial":"no","page":"2247-2302","article_processing_charge":"No","type":"journal_article","day":"18","month":"04","_id":"18958","article_type":"original","department":[{"_id":"RoSe"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2025-01-29T13:09:28Z","date_updated":"2026-09-17T11:09:16Z","das_tickbox":"0","intvolume":"        20","oa_version":"None","publication":"Oberwolfach Reports","doi":"10.4171/owr/2023/39","year":"2024","researchdata_availability":"no","volume":20,"publication_status":"published","citation":{"ista":"Hainzl C, Schlein B, Seiringer R, Warzel S. 2024. Many-body quantum systems. Oberwolfach Reports. 20(3), 2247–2302.","ama":"Hainzl C, Schlein B, Seiringer R, Warzel S. Many-body quantum systems. <i>Oberwolfach Reports</i>. 2024;20(3):2247-2302. doi:<a href=\"https://doi.org/10.4171/owr/2023/39\">10.4171/owr/2023/39</a>","mla":"Hainzl, Christian, et al. “Many-Body Quantum Systems.” <i>Oberwolfach Reports</i>, vol. 20, no. 3, EMS Press, 2024, pp. 2247–302, doi:<a href=\"https://doi.org/10.4171/owr/2023/39\">10.4171/owr/2023/39</a>.","chicago":"Hainzl, Christian, Benjamin Schlein, Robert Seiringer, and Simone Warzel. “Many-Body Quantum Systems.” <i>Oberwolfach Reports</i>. EMS Press, 2024. <a href=\"https://doi.org/10.4171/owr/2023/39\">https://doi.org/10.4171/owr/2023/39</a>.","apa":"Hainzl, C., Schlein, B., Seiringer, R., &#38; Warzel, S. (2024). Many-body quantum systems. <i>Oberwolfach Reports</i>. EMS Press. <a href=\"https://doi.org/10.4171/owr/2023/39\">https://doi.org/10.4171/owr/2023/39</a>","short":"C. Hainzl, B. Schlein, R. Seiringer, S. Warzel, Oberwolfach Reports 20 (2024) 2247–2302.","ieee":"C. Hainzl, B. Schlein, R. Seiringer, and S. Warzel, “Many-body quantum systems,” <i>Oberwolfach Reports</i>, vol. 20, no. 3. EMS Press, pp. 2247–2302, 2024."},"title":"Many-body quantum systems","abstract":[{"text":"This workshop brought together experts on the analysis of quantum many-body problems and quantum statistical mechanics, with the goal of discussing the state-of-the-art of the field, recent developments as well as challenges for the future. The main topics of discussion concerned the equilibrium and dynamical behavior of (bosonic or fermionic) quantum gases, quantum spin systems, as well as quantum field theory models like the Nelson or Fröhlich model.","lang":"eng"}],"acknowledgement":"The MFO and the workshop organizers would like to thank the National Science Foundation for supporting the participation of junior researchers in the workshop by the grant DMS-2230648, “US Junior Oberwolfach Fellows”.","publisher":"EMS Press","status":"public","issue":"3","quality_controlled":"1"}]