[{"corr_author":"1","abstract":[{"lang":"eng","text":"High carrier mobility is critical to improving thermoelectric performance over a broad temperature range. However, traditional doping inevitably deteriorates carrier mobility. Herein, we develop a strategy for fine tuning of defects to improve carrier mobility. To begin, n-type PbTe is created by compensating for the intrinsic Pb vacancy in bare PbTe. Excess Pb2+ reduces vacancy scattering, resulting in a high carrier mobility of ∼3400 cm2 V–1 s–1. Then, excess Ag is introduced to compensate for the remaining intrinsic Pb vacancies. We find that excess Ag exhibits a dynamic doping process with increasing temperatures, increasing both the carrier concentration and carrier mobility throughout a wide temperature range; specifically, an ultrahigh carrier mobility ∼7300 cm2 V–1 s–1 is obtained for Pb1.01Te + 0.002Ag at 300 K. Moreover, the dynamic doping-induced high carrier concentration suppresses the bipolar thermal conductivity at high temperatures. The final step is using iodine to optimize the carrier concentration to ∼1019 cm–3. Ultimately, a maximum ZT value of ∼1.5 and a large average ZTave value of ∼1.0 at 300–773 K are obtained for Pb1.01Te0.998I0.002 + 0.002Ag. These findings demonstrate that fine tuning of defects with <0.5% impurities can remarkably enhance carrier mobility and improve thermoelectric performance."}],"page":"755-763","ddc":["540"],"publication_status":"published","oa_version":"Published Version","isi":1,"department":[{"_id":"MaIb"}],"doi":"10.1021/acs.chemmater.2c03542","day":"24","has_accepted_license":"1","acknowledgement":"The National Key Research and Development Program of China (2018YFA0702100), the Basic Science Center Project of the National Natural Science Foundation of China (51788104), the National Natural Science Foundation of China (51571007 and 51772012), the Beijing Natural Science Foundation (JQ18004), the 111 Project (B17002), the National Science Fund for Distinguished Young Scholars (51925101), and the FWF “Lise Meitner Fellowship” (grant agreement M2889-N). Open Access is funded by the Austrian Science Fund (FWF).","oa":1,"status":"public","publication_identifier":{"issn":["0897-4756"],"eissn":["1520-5002"]},"scopus_import":"1","publication":"Chemistry of Materials","pmid":1,"quality_controlled":"1","publisher":"American Chemical Society","citation":{"mla":"Wang, Siqi, et al. “Fine Tuning of Defects Enables High Carrier Mobility and Enhanced Thermoelectric Performance of N-Type PbTe.” <i>Chemistry of Materials</i>, vol. 35, no. 2, American Chemical Society, 2023, pp. 755–63, doi:<a href=\"https://doi.org/10.1021/acs.chemmater.2c03542\">10.1021/acs.chemmater.2c03542</a>.","ama":"Wang S, Chang C, Bai S, et al. Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe. <i>Chemistry of Materials</i>. 2023;35(2):755-763. doi:<a href=\"https://doi.org/10.1021/acs.chemmater.2c03542\">10.1021/acs.chemmater.2c03542</a>","short":"S. Wang, C. Chang, S. Bai, B. Qin, Y. Zhu, S. Zhan, J. Zheng, S. Tang, L.D. Zhao, Chemistry of Materials 35 (2023) 755–763.","apa":"Wang, S., Chang, C., Bai, S., Qin, B., Zhu, Y., Zhan, S., … Zhao, L. D. (2023). Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe. <i>Chemistry of Materials</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.chemmater.2c03542\">https://doi.org/10.1021/acs.chemmater.2c03542</a>","ista":"Wang S, Chang C, Bai S, Qin B, Zhu Y, Zhan S, Zheng J, Tang S, Zhao LD. 2023. Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe. Chemistry of Materials. 35(2), 755–763.","ieee":"S. Wang <i>et al.</i>, “Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe,” <i>Chemistry of Materials</i>, vol. 35, no. 2. American Chemical Society, pp. 755–763, 2023.","chicago":"Wang, Siqi, Cheng Chang, Shulin Bai, Bingchao Qin, Yingcai Zhu, Shaoping Zhan, Junqing Zheng, Shuwei Tang, and Li Dong Zhao. “Fine Tuning of Defects Enables High Carrier Mobility and Enhanced Thermoelectric Performance of N-Type PbTe.” <i>Chemistry of Materials</i>. American Chemical Society, 2023. <a href=\"https://doi.org/10.1021/acs.chemmater.2c03542\">https://doi.org/10.1021/acs.chemmater.2c03542</a>."},"project":[{"grant_number":"M02889","_id":"9B8804FC-BA93-11EA-9121-9846C619BF3A","name":"Bottom-up Engineering for Thermoelectric Applications"}],"date_updated":"2025-04-23T08:47:37Z","author":[{"first_name":"Siqi","full_name":"Wang, Siqi","last_name":"Wang"},{"id":"9E331C2E-9F27-11E9-AE48-5033E6697425","last_name":"Chang","orcid":"0000-0002-9515-4277","full_name":"Chang, Cheng","first_name":"Cheng"},{"last_name":"Bai","first_name":"Shulin","full_name":"Bai, Shulin"},{"full_name":"Qin, Bingchao","first_name":"Bingchao","last_name":"Qin"},{"first_name":"Yingcai","full_name":"Zhu, Yingcai","last_name":"Zhu"},{"last_name":"Zhan","first_name":"Shaoping","full_name":"Zhan, Shaoping"},{"full_name":"Zheng, Junqing","first_name":"Junqing","last_name":"Zheng"},{"first_name":"Shuwei","full_name":"Tang, Shuwei","last_name":"Tang"},{"full_name":"Zhao, Li Dong","first_name":"Li Dong","last_name":"Zhao"}],"month":"01","article_type":"original","file":[{"date_created":"2023-08-14T12:57:25Z","creator":"dernst","access_level":"open_access","content_type":"application/pdf","file_size":2961043,"checksum":"b21dca2aa7a80c068bc256bdd1fea9df","success":1,"file_id":"14055","relation":"main_file","date_updated":"2023-08-14T12:57:25Z","file_name":"2023_ChemistryMaterials_Wang.pdf"}],"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-01-22T23:00:55Z","type":"journal_article","language":[{"iso":"eng"}],"intvolume":"        35","volume":35,"issue":"2","date_published":"2023-01-24T00:00:00Z","_id":"12331","title":"Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2023","external_id":{"pmid":["36711054"],"isi":["000914749700001"]},"file_date_updated":"2023-08-14T12:57:25Z"},{"isi":1,"department":[{"_id":"FlSc"},{"_id":"EM-Fac"}],"article_number":"add6495","doi":"10.1126/sciadv.add6495","day":"20","has_accepted_license":"1","corr_author":"1","abstract":[{"lang":"eng","text":"Regulation of the Arp2/3 complex is required for productive nucleation of branched actin networks. An emerging aspect of regulation is the incorporation of subunit isoforms into the Arp2/3 complex. Specifically, both ArpC5 subunit isoforms, ArpC5 and ArpC5L, have been reported to fine-tune nucleation activity and branch junction stability. We have combined reverse genetics and cellular structural biology to describe how ArpC5 and ArpC5L differentially affect cell migration. Both define the structural stability of ArpC1 in branch junctions and, in turn, by determining protrusion characteristics, affect protein dynamics and actin network ultrastructure. ArpC5 isoforms also affect the positioning of members of the Ena/Vasodilator-stimulated phosphoprotein (VASP) family of actin filament elongators, which mediate ArpC5 isoform–specific effects on the actin assembly level. Our results suggest that ArpC5 and Ena/VASP proteins are part of a signaling pathway enhancing cell migration.</jats:p>"}],"ddc":["570"],"keyword":["Multidisciplinary"],"publication_status":"published","oa_version":"Published Version","pmid":1,"quality_controlled":"1","publisher":"American Association for the Advancement of Science","citation":{"ama":"Fäßler F, Javoor M, Datler J, et al. ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. <i>Science Advances</i>. 2023;9(3). doi:<a href=\"https://doi.org/10.1126/sciadv.add6495\">10.1126/sciadv.add6495</a>","mla":"Fäßler, Florian, et al. “ArpC5 Isoforms Regulate Arp2/3 Complex–Dependent Protrusion through Differential Ena/VASP Positioning.” <i>Science Advances</i>, vol. 9, no. 3, add6495, American Association for the Advancement of Science, 2023, doi:<a href=\"https://doi.org/10.1126/sciadv.add6495\">10.1126/sciadv.add6495</a>.","ieee":"F. Fäßler <i>et al.</i>, “ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning,” <i>Science Advances</i>, vol. 9, no. 3. American Association for the Advancement of Science, 2023.","ista":"Fäßler F, Javoor M, Datler J, Döring H, Hofer F, Dimchev GA, Hodirnau V-V, Faix J, Rottner K, Schur FK. 2023. ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. Science Advances. 9(3), add6495.","chicago":"Fäßler, Florian, Manjunath Javoor, Julia Datler, Hermann Döring, Florian Hofer, Georgi A Dimchev, Victor-Valentin Hodirnau, Jan Faix, Klemens Rottner, and Florian KM Schur. “ArpC5 Isoforms Regulate Arp2/3 Complex–Dependent Protrusion through Differential Ena/VASP Positioning.” <i>Science Advances</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/sciadv.add6495\">https://doi.org/10.1126/sciadv.add6495</a>.","short":"F. Fäßler, M. Javoor, J. Datler, H. Döring, F. Hofer, G.A. Dimchev, V.-V. Hodirnau, J. Faix, K. Rottner, F.K. Schur, Science Advances 9 (2023).","apa":"Fäßler, F., Javoor, M., Datler, J., Döring, H., Hofer, F., Dimchev, G. A., … Schur, F. K. (2023). ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.add6495\">https://doi.org/10.1126/sciadv.add6495</a>"},"related_material":{"record":[{"relation":"research_data","id":"14562","status":"public"},{"id":"18766","status":"public","relation":"dissertation_contains"}]},"author":[{"last_name":"Fäßler","orcid":"0000-0001-7149-769X","id":"404F5528-F248-11E8-B48F-1D18A9856A87","full_name":"Fäßler, Florian","first_name":"Florian"},{"first_name":"Manjunath","full_name":"Javoor, Manjunath","last_name":"Javoor","orcid":"0000-0003-2311-2112","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2"},{"id":"3B12E2E6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3616-8580","last_name":"Datler","full_name":"Datler, Julia","first_name":"Julia"},{"full_name":"Döring, Hermann","first_name":"Hermann","last_name":"Döring"},{"full_name":"Hofer, Florian","first_name":"Florian","id":"b9d234ba-9e33-11ed-95b6-cd561df280e6","last_name":"Hofer"},{"first_name":"Georgi A","full_name":"Dimchev, Georgi A","orcid":"0000-0001-8370-6161","id":"38C393BE-F248-11E8-B48F-1D18A9856A87","last_name":"Dimchev"},{"last_name":"Hodirnau","id":"3661B498-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3904-947X","first_name":"Victor-Valentin","full_name":"Hodirnau, Victor-Valentin"},{"full_name":"Faix, Jan","first_name":"Jan","last_name":"Faix"},{"last_name":"Rottner","first_name":"Klemens","full_name":"Rottner, Klemens"},{"first_name":"Florian KM","full_name":"Schur, Florian KM","last_name":"Schur","orcid":"0000-0003-4790-8078","id":"48AD8942-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2026-04-07T12:59:44Z","project":[{"grant_number":"P33367","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","name":"Structure and isoform diversity of the Arp2/3 complex"}],"oa":1,"acknowledgement":"We would like to thank K. von Peinen and B. Denker (Helmholtz Centre for Infection Research, Braunschweig, Germany) for experimental and technical assistance, respectively.\r\nThis research was supported by the Scientific Service Units (SSUs) of ISTA through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the Imaging and Optics facility (IOF), and the Electron Microscopy Facility (EMF). We acknowledge support from ISTA and from the Austrian Science Fund (FWF) (P33367) to F.K.M.S., from the Research Training Group GRK2223 and the Helmholtz Society to K.R,. and from the Deutsche Forschungsgemeinschaft (DFG) to J.F. and K.R.","status":"public","publication_identifier":{"issn":["2375-2548"]},"scopus_import":"1","publication":"Science Advances","language":[{"iso":"eng"}],"intvolume":"         9","volume":9,"issue":"3","file":[{"success":1,"file_id":"12335","date_updated":"2023-01-23T07:45:54Z","relation":"main_file","file_name":"2023_ScienceAdvances_Faessler.pdf","access_level":"open_access","creator":"dernst","date_created":"2023-01-23T07:45:54Z","file_size":1756234,"content_type":"application/pdf","checksum":"ce81a6d0b84170e5e8c62f6acfa15d9e"}],"month":"01","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","date_created":"2023-01-23T07:26:42Z","type":"journal_article","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"EM-Fac"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning","year":"2023","external_id":{"pmid":["36662867"],"isi":["000964550100015"]},"file_date_updated":"2023-01-23T07:45:54Z","date_published":"2023-01-20T00:00:00Z","_id":"12334"},{"language":[{"iso":"eng"}],"intvolume":"       207","volume":207,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2103.08268"}],"article_type":"original","month":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","date_created":"2023-01-26T21:17:04Z","type":"journal_article","arxiv":1,"title":"Density of the union of positive diagonal binary quadratic forms","year":"2023","external_id":{"arxiv":["2103.08268"],"isi":["000912903000001"]},"date_published":"2023-01-09T00:00:00Z","_id":"12406","isi":1,"department":[{"_id":"GradSch"}],"doi":"10.4064/aa210830-24-11","day":"09","abstract":[{"lang":"eng","text":"Let X be a sufficiently large positive integer. We prove that one may choose a subset S of primes with cardinality O(logX) such that a positive proportion of integers less than X can be represented by x2+py2 for at least one p∈S."}],"corr_author":"1","page":"1-17","keyword":["Algebra","Number Theory"],"publication_status":"published","oa_version":"Preprint","quality_controlled":"1","publisher":"Instytut Matematyczny","citation":{"ama":"Diao Y. Density of the union of positive diagonal binary quadratic forms. <i>Acta Arithmetica</i>. 2023;207:1-17. doi:<a href=\"https://doi.org/10.4064/aa210830-24-11\">10.4064/aa210830-24-11</a>","mla":"Diao, Yijie. “Density of the Union of Positive Diagonal Binary Quadratic Forms.” <i>Acta Arithmetica</i>, vol. 207, Instytut Matematyczny, 2023, pp. 1–17, doi:<a href=\"https://doi.org/10.4064/aa210830-24-11\">10.4064/aa210830-24-11</a>.","ieee":"Y. Diao, “Density of the union of positive diagonal binary quadratic forms,” <i>Acta Arithmetica</i>, vol. 207. Instytut Matematyczny, pp. 1–17, 2023.","ista":"Diao Y. 2023. Density of the union of positive diagonal binary quadratic forms. Acta Arithmetica. 207, 1–17.","chicago":"Diao, Yijie. “Density of the Union of Positive Diagonal Binary Quadratic Forms.” <i>Acta Arithmetica</i>. Instytut Matematyczny, 2023. <a href=\"https://doi.org/10.4064/aa210830-24-11\">https://doi.org/10.4064/aa210830-24-11</a>.","apa":"Diao, Y. (2023). Density of the union of positive diagonal binary quadratic forms. <i>Acta Arithmetica</i>. Instytut Matematyczny. <a href=\"https://doi.org/10.4064/aa210830-24-11\">https://doi.org/10.4064/aa210830-24-11</a>","short":"Y. Diao, Acta Arithmetica 207 (2023) 1–17."},"date_updated":"2024-10-21T06:01:30Z","author":[{"first_name":"Yijie","full_name":"Diao, Yijie","id":"7b7eb4ca-eb2c-11ec-b98b-accec0b20c3b","orcid":"0000-0002-4989-5330","last_name":"Diao"}],"acknowledgement":"This article is a version the author’s master thesis at the University of Bonn. The author would like to thank his advisor Valentin Blomer for introducing the problem, and giving generous feedback and encouragement along the way, especially during the global pandemic.\r\nThe author thanks Edgar Assing for his lectures on analytic number theory. Finally, the author is grateful to the anonymous referees for their valuable time and comments.\r\n","oa":1,"status":"public","publication_identifier":{"issn":["0065-1036"],"eissn":["1730-6264"]},"scopus_import":"1","publication":"Acta Arithmetica"},{"ec_funded":1,"project":[{"call_identifier":"H2020","grant_number":"101020093","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","name":"Vigilant Algorithmic Monitoring of Software"}],"author":[{"full_name":"Chalupa, Marek","first_name":"Marek","id":"87e34708-d6c6-11ec-9f5b-9391e7be2463","last_name":"Chalupa"},{"id":"6395C5F6-89DF-11E9-9C97-6BDFE5697425","last_name":"Mühlböck","orcid":"0000-0003-1548-0177","full_name":"Mühlböck, Fabian","first_name":"Fabian"},{"id":"a376de31-8972-11ed-ae7b-d0251c13c8ff","last_name":"Muroya Lei","first_name":"Stefanie","full_name":"Muroya Lei, Stefanie"},{"orcid":"0000-0002-2985-7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","first_name":"Thomas A","full_name":"Henzinger, Thomas A"}],"date_updated":"2025-09-09T12:25:29Z","related_material":{"record":[{"status":"public","id":"12856","relation":"later_version"}]},"publisher":"Institute of Science and Technology Austria","citation":{"ista":"Chalupa M, Mühlböck F, Muroya Lei S, Henzinger TA. 2023. VAMOS: Middleware for Best-Effort Third-Party Monitoring, Institute of Science and Technology Austria, 38p.","chicago":"Chalupa, Marek, Fabian Mühlböck, Stefanie Muroya Lei, and Thomas A Henzinger. <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/AT:ISTA:12407\">https://doi.org/10.15479/AT:ISTA:12407</a>.","ieee":"M. Chalupa, F. Mühlböck, S. Muroya Lei, and T. A. Henzinger, <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria, 2023.","apa":"Chalupa, M., Mühlböck, F., Muroya Lei, S., &#38; Henzinger, T. A. (2023). <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:12407\">https://doi.org/10.15479/AT:ISTA:12407</a>","short":"M. Chalupa, F. Mühlböck, S. Muroya Lei, T.A. Henzinger, VAMOS: Middleware for Best-Effort Third-Party Monitoring, Institute of Science and Technology Austria, 2023.","ama":"Chalupa M, Mühlböck F, Muroya Lei S, Henzinger TA. <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria; 2023. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12407\">10.15479/AT:ISTA:12407</a>","mla":"Chalupa, Marek, et al. <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12407\">10.15479/AT:ISTA:12407</a>."},"status":"public","publication_identifier":{"eissn":["2664-1690"]},"acknowledgement":"This work was supported in part by the ERC-2020-AdG 101020093. \r\nThe authors would like to thank the anonymous FASE reviewers for their valuable feedback and suggestions.","oa":1,"alternative_title":["IST Austria Technical Report"],"department":[{"_id":"ToHe"}],"day":"27","has_accepted_license":"1","doi":"10.15479/AT:ISTA:12407","ddc":["005"],"keyword":["runtime monitoring","best effort","third party"],"publication_status":"published","corr_author":"1","abstract":[{"lang":"eng","text":"As the complexity and criticality of software increase every year, so does the importance of run-time monitoring. Third-party monitoring, with limited knowledge of the monitored software, and best-effort monitoring, which keeps pace with the monitored software, are especially valuable, yet underexplored areas of run-time monitoring. Most existing monitoring frameworks do not support their combination because they either require access to the monitored code for instrumentation purposes or the processing of all observed events, or both.\r\n\r\nWe present a middleware framework, VAMOS, for the run-time monitoring of software which is explicitly designed to support third-party and best-effort scenarios. The design goals of VAMOS are (i) efficiency (keeping pace at low overhead), (ii) flexibility (the ability to monitor black-box code through a variety of different event channels, and the connectability to monitors written in different specification languages), and (iii) ease-of-use. To achieve its goals, VAMOS combines aspects of event broker and event recognition systems with aspects of stream processing systems.\r\n\r\nWe implemented a prototype toolchain for VAMOS and conducted experiments including a case study of monitoring for data races. The results indicate that VAMOS enables writing useful yet efficient monitors, is compatible with a variety of event sources and monitor specifications, and simplifies key aspects of setting up a monitoring system from scratch."}],"page":"38","oa_version":"Published Version","year":"2023","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"VAMOS: Middleware for Best-Effort Third-Party Monitoring","file_date_updated":"2023-01-27T03:18:34Z","_id":"12407","date_published":"2023-01-27T00:00:00Z","language":[{"iso":"eng"}],"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"checksum":"55426e463fdeafe9777fc3ff635154c7","file_size":662409,"content_type":"application/pdf","creator":"fmuehlbo","access_level":"open_access","date_created":"2023-01-27T03:18:34Z","file_name":"main.pdf","date_updated":"2023-01-27T03:18:34Z","relation":"main_file","success":1,"file_id":"12408"}],"month":"01","type":"technical_report","date_created":"2023-01-27T03:18:08Z"},{"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"02","file":[{"creator":"dernst","date_created":"2023-03-16T07:58:16Z","access_level":"open_access","content_type":"application/pdf","file_size":10045006,"checksum":"4e7069845e3dad22bb44fb71ec624c60","success":1,"file_id":"12728","relation":"main_file","date_updated":"2023-03-16T07:58:16Z","file_name":"2023_BioChemicalSocietyTransactions_Faessler.pdf"}],"article_type":"original","type":"journal_article","date_created":"2023-01-27T10:08:19Z","volume":51,"language":[{"iso":"eng"}],"intvolume":"        51","issue":"1","_id":"12421","date_published":"2023-02-01T00:00:00Z","year":"2023","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM","file_date_updated":"2023-03-16T07:58:16Z","external_id":{"isi":["000926043100001"],"pmid":["36695514"]},"publication_status":"published","keyword":["Biochemistry"],"ddc":["570"],"page":"87-99","corr_author":"1","abstract":[{"text":"The actin cytoskeleton plays a key role in cell migration and cellular morphodynamics in most eukaryotes. The ability of the actin cytoskeleton to assemble and disassemble in a spatiotemporally controlled manner allows it to form higher-order structures, which can generate forces required for a cell to explore and navigate through its environment. It is regulated not only via a complex synergistic and competitive interplay between actin-binding proteins (ABP), but also by filament biochemistry and filament geometry. The lack of structural insights into how geometry and ABPs regulate the actin cytoskeleton limits our understanding of the molecular mechanisms that define actin cytoskeleton remodeling and, in turn, impact emerging cell migration characteristics. With the advent of cryo-electron microscopy (cryo-EM) and advanced computational methods, it is now possible to define these molecular mechanisms involving actin and its interactors at both atomic and ultra-structural levels in vitro and in cellulo. In this review, we will provide an overview of the available cryo-EM methods, applicable to further our understanding of the actin cytoskeleton, specifically in the context of cell migration. We will discuss how these methods have been employed to elucidate ABP- and geometry-defined regulatory mechanisms in initiating, maintaining, and disassembling cellular actin networks in migratory protrusions.","lang":"eng"}],"oa_version":"Published Version","department":[{"_id":"FlSc"}],"isi":1,"day":"01","has_accepted_license":"1","doi":"10.1042/bst20220221","publication_identifier":{"issn":["0300-5127"],"eissn":["1470-8752"]},"status":"public","oa":1,"acknowledgement":"We apologize for not being able to mention and cite additional excellent work that would have fit the scope of this review, due to space restraints. We thank Jesse Hansen for comments on the manuscript. We acknowledge support from the Austrian Science Fund (FWF): P33367 and the Institute of Science and Technology Austria.","publication":"Biochemical Society Transactions","scopus_import":"1","quality_controlled":"1","pmid":1,"author":[{"orcid":"0000-0001-7149-769X","id":"404F5528-F248-11E8-B48F-1D18A9856A87","last_name":"Fäßler","full_name":"Fäßler, Florian","first_name":"Florian"},{"last_name":"Javoor","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","full_name":"Javoor, Manjunath","first_name":"Manjunath"},{"first_name":"Florian KM","full_name":"Schur, Florian KM","last_name":"Schur","orcid":"0000-0003-4790-8078","id":"48AD8942-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2025-04-23T08:47:15Z","project":[{"name":"Structure and isoform diversity of the Arp2/3 complex","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","grant_number":"P33367"}],"citation":{"short":"F. Fäßler, M. Javoor, F.K. Schur, Biochemical Society Transactions 51 (2023) 87–99.","apa":"Fäßler, F., Javoor, M., &#38; Schur, F. K. (2023). Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM. <i>Biochemical Society Transactions</i>. Portland Press. <a href=\"https://doi.org/10.1042/bst20220221\">https://doi.org/10.1042/bst20220221</a>","ista":"Fäßler F, Javoor M, Schur FK. 2023. Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM. Biochemical Society Transactions. 51(1), 87–99.","ieee":"F. Fäßler, M. Javoor, and F. K. Schur, “Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM,” <i>Biochemical Society Transactions</i>, vol. 51, no. 1. Portland Press, pp. 87–99, 2023.","chicago":"Fäßler, Florian, Manjunath Javoor, and Florian KM Schur. “Deciphering the Molecular Mechanisms of Actin Cytoskeleton Regulation in Cell Migration Using Cryo-EM.” <i>Biochemical Society Transactions</i>. Portland Press, 2023. <a href=\"https://doi.org/10.1042/bst20220221\">https://doi.org/10.1042/bst20220221</a>.","mla":"Fäßler, Florian, et al. “Deciphering the Molecular Mechanisms of Actin Cytoskeleton Regulation in Cell Migration Using Cryo-EM.” <i>Biochemical Society Transactions</i>, vol. 51, no. 1, Portland Press, 2023, pp. 87–99, doi:<a href=\"https://doi.org/10.1042/bst20220221\">10.1042/bst20220221</a>.","ama":"Fäßler F, Javoor M, Schur FK. Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM. <i>Biochemical Society Transactions</i>. 2023;51(1):87-99. doi:<a href=\"https://doi.org/10.1042/bst20220221\">10.1042/bst20220221</a>"},"publisher":"Portland Press"},{"corr_author":"1","abstract":[{"lang":"eng","text":"Let k be a number field and X a smooth, geometrically integral quasi-projective variety over k. For any linear algebraic group G over k and any G-torsor g : Z → X, we observe that if the étale-Brauer obstruction is the only one for strong approximation off a finite set of places S for all twists of Z by elements in H^1(k, G), then the étale-Brauer obstruction is the only one for strong approximation off a finite set of places S for X. As an application, we show that any homogeneous space of the form G/H with G a connected linear algebraic group over k satisfies strong approximation off the infinite places with étale-Brauer obstruction, under some compactness assumptions when k is totally real. We also prove more refined strong approximation results for homogeneous spaces of the form G/H with G semisimple simply connected and H finite, using the theory of torsors and descent."}],"page":"907-914","publication_status":"published","oa_version":"Preprint","isi":1,"department":[{"_id":"TiBr"}],"doi":"10.1090/proc/15239","day":"01","oa":1,"status":"public","publication_identifier":{"issn":["0002-9939"],"eissn":["1088-6826"]},"publication":"Proceedings of the American Mathematical Society","scopus_import":"1","quality_controlled":"1","citation":{"apa":"Balestrieri, F. (2023). Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups. <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society. <a href=\"https://doi.org/10.1090/proc/15239\">https://doi.org/10.1090/proc/15239</a>","short":"F. Balestrieri, Proceedings of the American Mathematical Society 151 (2023) 907–914.","ieee":"F. Balestrieri, “Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups,” <i>Proceedings of the American Mathematical Society</i>, vol. 151, no. 3. American Mathematical Society, pp. 907–914, 2023.","ista":"Balestrieri F. 2023. Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups. Proceedings of the American Mathematical Society. 151(3), 907–914.","chicago":"Balestrieri, Francesca. “Some Remarks on Strong Approximation and Applications to Homogeneous Spaces of Linear Algebraic Groups.” <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society, 2023. <a href=\"https://doi.org/10.1090/proc/15239\">https://doi.org/10.1090/proc/15239</a>.","mla":"Balestrieri, Francesca. “Some Remarks on Strong Approximation and Applications to Homogeneous Spaces of Linear Algebraic Groups.” <i>Proceedings of the American Mathematical Society</i>, vol. 151, no. 3, American Mathematical Society, 2023, pp. 907–14, doi:<a href=\"https://doi.org/10.1090/proc/15239\">10.1090/proc/15239</a>.","ama":"Balestrieri F. Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups. <i>Proceedings of the American Mathematical Society</i>. 2023;151(3):907-914. doi:<a href=\"https://doi.org/10.1090/proc/15239\">10.1090/proc/15239</a>"},"publisher":"American Mathematical Society","date_updated":"2024-10-09T21:04:07Z","author":[{"id":"3ACCD756-F248-11E8-B48F-1D18A9856A87","last_name":"Balestrieri","full_name":"Balestrieri, Francesca","first_name":"Francesca"}],"month":"01","article_type":"original","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","date_created":"2023-01-29T23:00:58Z","type":"journal_article","intvolume":"       151","language":[{"iso":"eng"}],"volume":151,"issue":"3","main_file_link":[{"open_access":"1","url":"https://hal.science/hal-03013498/"}],"date_published":"2023-01-01T00:00:00Z","_id":"12427","title":"Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups","year":"2023","external_id":{"isi":["000898440000001"]}},{"date_published":"2023-01-19T00:00:00Z","_id":"12428","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"A Guide Toward Multi-scale and Quantitative Branching Analysis in the Mammary Gland","year":"2023","editor":[{"last_name":"Margadant","full_name":"Margadant, Coert","first_name":"Coert"}],"external_id":{"pmid":["36653709"]},"file_date_updated":"2023-02-03T10:56:39Z","month":"01","file":[{"success":1,"file_id":"12500","relation":"main_file","date_updated":"2023-02-03T10:56:39Z","file_name":"2023_MIMB_Hannezo.pdf","access_level":"open_access","date_created":"2023-02-03T10:56:39Z","creator":"dernst","content_type":"application/pdf","file_size":826598,"checksum":"aec1b8d3ba938ddf9d8fcb777f3c38ee"}],"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-01-29T23:00:58Z","type":"book_chapter","intvolume":"      2608","language":[{"iso":"eng"}],"volume":2608,"oa":1,"status":"public","publication_identifier":{"eisbn":["9781071628874"],"isbn":["9781071628867"],"eissn":["1940-6029"]},"alternative_title":["Methods in Molecular Biology"],"publication":"Cell Migration in Three Dimensions","scopus_import":"1","series_title":"MIMB","pmid":1,"quality_controlled":"1","publisher":"Springer Nature","citation":{"mla":"Hannezo, Edouard B., and Colinda L. G. J. Scheele. “A Guide Toward Multi-Scale and Quantitative Branching Analysis in the Mammary Gland.” <i>Cell Migration in Three Dimensions</i>, edited by Coert Margadant, vol. 2608, Springer Nature, 2023, pp. 183–205, doi:<a href=\"https://doi.org/10.1007/978-1-0716-2887-4_12\">10.1007/978-1-0716-2887-4_12</a>.","ama":"Hannezo EB, Scheele CLGJ. A Guide Toward Multi-scale and Quantitative Branching Analysis in the Mammary Gland. In: Margadant C, ed. <i>Cell Migration in Three Dimensions</i>. Vol 2608. MIMB. Springer Nature; 2023:183-205. doi:<a href=\"https://doi.org/10.1007/978-1-0716-2887-4_12\">10.1007/978-1-0716-2887-4_12</a>","short":"E.B. Hannezo, C.L.G.J. Scheele, in:, C. Margadant (Ed.), Cell Migration in Three Dimensions, Springer Nature, 2023, pp. 183–205.","apa":"Hannezo, E. B., &#38; Scheele, C. L. G. J. (2023). A Guide Toward Multi-scale and Quantitative Branching Analysis in the Mammary Gland. In C. Margadant (Ed.), <i>Cell Migration in Three Dimensions</i> (Vol. 2608, pp. 183–205). Springer Nature. <a href=\"https://doi.org/10.1007/978-1-0716-2887-4_12\">https://doi.org/10.1007/978-1-0716-2887-4_12</a>","ista":"Hannezo EB, Scheele CLGJ. 2023.A Guide Toward Multi-scale and Quantitative Branching Analysis in the Mammary Gland. In: Cell Migration in Three Dimensions. Methods in Molecular Biology, vol. 2608, 183–205.","chicago":"Hannezo, Edouard B, and Colinda L.G.J. Scheele. “A Guide Toward Multi-Scale and Quantitative Branching Analysis in the Mammary Gland.” In <i>Cell Migration in Three Dimensions</i>, edited by Coert Margadant, 2608:183–205. MIMB. Springer Nature, 2023. <a href=\"https://doi.org/10.1007/978-1-0716-2887-4_12\">https://doi.org/10.1007/978-1-0716-2887-4_12</a>.","ieee":"E. B. Hannezo and C. L. G. J. Scheele, “A Guide Toward Multi-scale and Quantitative Branching Analysis in the Mammary Gland,” in <i>Cell Migration in Three Dimensions</i>, vol. 2608, C. Margadant, Ed. Springer Nature, 2023, pp. 183–205."},"date_updated":"2024-10-09T21:04:04Z","author":[{"last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6005-1561","first_name":"Edouard B","full_name":"Hannezo, Edouard B"},{"full_name":"Scheele, Colinda L.G.J.","first_name":"Colinda L.G.J.","last_name":"Scheele"}],"corr_author":"1","abstract":[{"lang":"eng","text":"The mammary gland consists of a bilayered epithelial structure with an extensively branched morphology. The majority of this epithelial tree is laid down during puberty, during which actively proliferating terminal end buds repeatedly elongate and bifurcate to form the basic structure of the ductal tree. Mammary ducts consist of a basal and luminal cell layer with a multitude of identified sub-lineages within both layers. The understanding of how these different cell lineages are cooperatively driving branching morphogenesis is a problem of crossing multiple scales, as this requires information on the macroscopic branched structure of the gland, as well as data on single-cell dynamics driving the morphogenic program. Here we describe a method to combine genetic lineage tracing with whole-gland branching analysis. Quantitative data on the global organ structure can be used to derive a model for mammary gland branching morphogenesis and provide a backbone on which the dynamics of individual cell lineages can be simulated and compared to lineage-tracing approaches. Eventually, these quantitative models and experiments allow to understand the couplings between the macroscopic shape of the mammary gland and the underlying single-cell dynamics driving branching morphogenesis."}],"page":"183-205","ddc":["570"],"publication_status":"published","oa_version":"Published Version","department":[{"_id":"EdHa"}],"doi":"10.1007/978-1-0716-2887-4_12","has_accepted_license":"1","day":"19"},{"external_id":{"arxiv":["2104.05063"],"isi":["000914134900001"]},"file_date_updated":"2023-08-16T11:40:02Z","arxiv":1,"title":"On the trace embedding and its applications to evolution equations","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"year":"2023","date_published":"2023-04-01T00:00:00Z","_id":"12429","issue":"4","language":[{"iso":"eng"}],"intvolume":"       296","volume":296,"date_created":"2023-01-29T23:00:59Z","type":"journal_article","license":"https://creativecommons.org/licenses/by-nc/4.0/","file":[{"file_size":449280,"content_type":"application/pdf","creator":"dernst","access_level":"open_access","date_created":"2023-08-16T11:40:02Z","checksum":"6f099f1d064173784d1a27716a2cc795","date_updated":"2023-08-16T11:40:02Z","relation":"main_file","file_id":"14067","success":1,"file_name":"2023_MathNachrichten_Agresti.pdf"}],"month":"04","article_type":"original","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Wiley","citation":{"ama":"Agresti A, Lindemulder N, Veraar M. On the trace embedding and its applications to evolution equations. <i>Mathematische Nachrichten</i>. 2023;296(4):1319-1350. doi:<a href=\"https://doi.org/10.1002/mana.202100192\">10.1002/mana.202100192</a>","mla":"Agresti, Antonio, et al. “On the Trace Embedding and Its Applications to Evolution Equations.” <i>Mathematische Nachrichten</i>, vol. 296, no. 4, Wiley, 2023, pp. 1319–50, doi:<a href=\"https://doi.org/10.1002/mana.202100192\">10.1002/mana.202100192</a>.","chicago":"Agresti, Antonio, Nick Lindemulder, and Mark Veraar. “On the Trace Embedding and Its Applications to Evolution Equations.” <i>Mathematische Nachrichten</i>. Wiley, 2023. <a href=\"https://doi.org/10.1002/mana.202100192\">https://doi.org/10.1002/mana.202100192</a>.","ieee":"A. Agresti, N. Lindemulder, and M. Veraar, “On the trace embedding and its applications to evolution equations,” <i>Mathematische Nachrichten</i>, vol. 296, no. 4. Wiley, pp. 1319–1350, 2023.","ista":"Agresti A, Lindemulder N, Veraar M. 2023. On the trace embedding and its applications to evolution equations. Mathematische Nachrichten. 296(4), 1319–1350.","short":"A. Agresti, N. Lindemulder, M. Veraar, Mathematische Nachrichten 296 (2023) 1319–1350.","apa":"Agresti, A., Lindemulder, N., &#38; Veraar, M. (2023). On the trace embedding and its applications to evolution equations. <i>Mathematische Nachrichten</i>. Wiley. <a href=\"https://doi.org/10.1002/mana.202100192\">https://doi.org/10.1002/mana.202100192</a>"},"author":[{"last_name":"Agresti","orcid":"0000-0002-9573-2962","id":"673cd0cc-9b9a-11eb-b144-88f30e1fbb72","full_name":"Agresti, Antonio","first_name":"Antonio"},{"last_name":"Lindemulder","full_name":"Lindemulder, Nick","first_name":"Nick"},{"full_name":"Veraar, Mark","first_name":"Mark","last_name":"Veraar"}],"date_updated":"2023-08-16T11:41:42Z","quality_controlled":"1","publication":"Mathematische Nachrichten","scopus_import":"1","oa":1,"acknowledgement":"The first author has been partially supported by the Nachwuchsring—Network for the promotion of young scientists—at TU Kaiserslautern. The second and third authors were supported by the Vidi subsidy 639.032.427 of the Netherlands Organisation for Scientific Research (NWO).","status":"public","publication_identifier":{"issn":["0025-584X"],"eissn":["1522-2616"]},"doi":"10.1002/mana.202100192","has_accepted_license":"1","day":"01","isi":1,"department":[{"_id":"JuFi"}],"oa_version":"Published Version","abstract":[{"text":"In this paper, we consider traces at initial times for functions with mixed time-space smoothness. Such results are often needed in the theory of evolution equations. Our result extends and unifies many previous results. Our main improvement is that we can allow general interpolation couples. The abstract results are applied to regularity problems for fractional evolution equations and stochastic evolution equations, where uniform trace estimates on the half-line are shown.","lang":"eng"}],"page":"1319-1350","ddc":["510"],"publication_status":"published"},{"publisher":"World Scientific Publishing","citation":{"ama":"Falconi M, Leopold NK, Mitrouskas DJ, Petrat SP. Bogoliubov dynamics and higher-order corrections for the regularized Nelson model. <i>Reviews in Mathematical Physics</i>. 2023;35(4). doi:<a href=\"https://doi.org/10.1142/S0129055X2350006X\">10.1142/S0129055X2350006X</a>","mla":"Falconi, Marco, et al. “Bogoliubov Dynamics and Higher-Order Corrections for the Regularized Nelson Model.” <i>Reviews in Mathematical Physics</i>, vol. 35, no. 4, 2350006, World Scientific Publishing, 2023, doi:<a href=\"https://doi.org/10.1142/S0129055X2350006X\">10.1142/S0129055X2350006X</a>.","chicago":"Falconi, Marco, Nikolai K Leopold, David Johannes Mitrouskas, and Sören P Petrat. “Bogoliubov Dynamics and Higher-Order Corrections for the Regularized Nelson Model.” <i>Reviews in Mathematical Physics</i>. World Scientific Publishing, 2023. <a href=\"https://doi.org/10.1142/S0129055X2350006X\">https://doi.org/10.1142/S0129055X2350006X</a>.","ista":"Falconi M, Leopold NK, Mitrouskas DJ, Petrat SP. 2023. Bogoliubov dynamics and higher-order corrections for the regularized Nelson model. Reviews in Mathematical Physics. 35(4), 2350006.","ieee":"M. Falconi, N. K. Leopold, D. J. Mitrouskas, and S. P. Petrat, “Bogoliubov dynamics and higher-order corrections for the regularized Nelson model,” <i>Reviews in Mathematical Physics</i>, vol. 35, no. 4. World Scientific Publishing, 2023.","short":"M. Falconi, N.K. Leopold, D.J. Mitrouskas, S.P. Petrat, Reviews in Mathematical Physics 35 (2023).","apa":"Falconi, M., Leopold, N. K., Mitrouskas, D. J., &#38; Petrat, S. P. (2023). Bogoliubov dynamics and higher-order corrections for the regularized Nelson model. <i>Reviews in Mathematical Physics</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/S0129055X2350006X\">https://doi.org/10.1142/S0129055X2350006X</a>"},"author":[{"first_name":"Marco","full_name":"Falconi, Marco","last_name":"Falconi"},{"full_name":"Leopold, Nikolai K","first_name":"Nikolai K","last_name":"Leopold","id":"4BC40BEC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0495-6822"},{"id":"cbddacee-2b11-11eb-a02e-a2e14d04e52d","last_name":"Mitrouskas","first_name":"David Johannes","full_name":"Mitrouskas, David Johannes"},{"full_name":"Petrat, Sören P","first_name":"Sören P","last_name":"Petrat","orcid":"0000-0002-9166-5889","id":"40AC02DC-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2023-08-16T11:47:27Z","quality_controlled":"1","scopus_import":"1","publication":"Reviews in Mathematical Physics","oa":1,"status":"public","publication_identifier":{"issn":["0129-055X"]},"article_number":"2350006","doi":"10.1142/S0129055X2350006X","day":"09","isi":1,"department":[{"_id":"RoSe"}],"oa_version":"Preprint","abstract":[{"text":"We study the time evolution of the Nelson model in a mean-field limit in which N nonrelativistic bosons weakly couple (with respect to the particle number) to a positive or zero mass quantized scalar field. Our main result is the derivation of the Bogoliubov dynamics and higher-order corrections. More precisely, we prove the convergence of the approximate wave function to the many-body wave function in norm, with a convergence rate proportional to the number of corrections taken into account in the approximation. We prove an analogous result for the unitary propagator. As an application, we derive a simple system of partial differential equations describing the time evolution of the first- and second-order approximations to the one-particle reduced density matrices of the particles and the quantum field, respectively.","lang":"eng"}],"publication_status":"published","external_id":{"arxiv":["2110.00458"],"isi":["000909760300001"]},"arxiv":1,"title":"Bogoliubov dynamics and higher-order corrections for the regularized Nelson model","year":"2023","date_published":"2023-01-09T00:00:00Z","_id":"12430","issue":"4","main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2110.00458"}],"language":[{"iso":"eng"}],"intvolume":"        35","volume":35,"date_created":"2023-01-29T23:00:59Z","type":"journal_article","month":"01","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No"},{"intvolume":"     13992","language":[{"iso":"eng"}],"volume":13992,"date_created":"2023-01-31T07:23:56Z","type":"conference","month":"04","file":[{"checksum":"981025aed580b6b27c426cb8856cf63e","date_created":"2023-01-31T07:22:21Z","access_level":"open_access","creator":"esarac","content_type":"application/pdf","file_size":449027,"file_name":"qsl.pdf","success":1,"file_id":"12468","relation":"main_file","date_updated":"2023-01-31T07:22:21Z"},{"file_size":1048171,"content_type":"application/pdf","creator":"dernst","access_level":"open_access","date_created":"2023-06-19T10:28:09Z","checksum":"f16e2af1e0eb243158ab0f0fe74e7d5a","date_updated":"2023-06-19T10:28:09Z","relation":"main_file","file_id":"13153","success":1,"file_name":"2023_LNCS_HenzingerT.pdf"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_processing_charge":"No","external_id":{"arxiv":["2301.11175"],"isi":["001288609300017"]},"file_date_updated":"2023-06-19T10:28:09Z","title":"Quantitative safety and liveness","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"arxiv":1,"year":"2023","date_published":"2023-04-21T00:00:00Z","_id":"12467","doi":"10.1007/978-3-031-30829-1_17","has_accepted_license":"1","day":"21","department":[{"_id":"GradSch"},{"_id":"ToHe"}],"isi":1,"conference":{"name":"FOSSACS: Foundations of Software Science and Computation Structures","location":"Paris, France","end_date":"2023-04-27","start_date":"2023-04-22"},"oa_version":"Published Version","page":"349-370","abstract":[{"lang":"eng","text":"Safety and liveness are elementary concepts of computation, and the foundation of many verification paradigms. The safety-liveness classification of boolean properties characterizes whether a given property can be falsified by observing a finite prefix of an infinite computation trace (always for safety, never for liveness). In quantitative specification and verification, properties assign not truth values, but quantitative values to infinite traces (e.g., a cost, or the distance to a boolean property). We introduce quantitative safety and liveness, and we prove that our definitions induce conservative quantitative generalizations of both (1)~the safety-progress hierarchy of boolean properties and (2)~the safety-liveness decomposition of boolean properties. In particular, we show that every quantitative property can be written as the pointwise minimum of a quantitative safety property and a quantitative liveness property. Consequently, like boolean properties, also quantitative properties can be min-decomposed into safety and liveness parts, or alternatively, max-decomposed into co-safety and co-liveness parts. Moreover, quantitative properties can be approximated naturally. We prove that every quantitative property that has both safe and co-safe approximations can be monitored arbitrarily precisely by a monitor that uses only a finite number of states."}],"corr_author":"1","publication_status":"published","ddc":["000"],"publisher":"Springer Nature","citation":{"apa":"Henzinger, T. A., Mazzocchi, N. A., &#38; Sarac, N. E. (2023). Quantitative safety and liveness. In <i>26th International Conference Foundations of Software Science and Computation Structures</i> (Vol. 13992, pp. 349–370). Paris, France: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-30829-1_17\">https://doi.org/10.1007/978-3-031-30829-1_17</a>","short":"T.A. Henzinger, N.A. Mazzocchi, N.E. Sarac, in:, 26th International Conference Foundations of Software Science and Computation Structures, Springer Nature, 2023, pp. 349–370.","ieee":"T. A. Henzinger, N. A. Mazzocchi, and N. E. Sarac, “Quantitative safety and liveness,” in <i>26th International Conference Foundations of Software Science and Computation Structures</i>, Paris, France, 2023, vol. 13992, pp. 349–370.","ista":"Henzinger TA, Mazzocchi NA, Sarac NE. 2023. Quantitative safety and liveness. 26th International Conference Foundations of Software Science and Computation Structures. FOSSACS: Foundations of Software Science and Computation Structures, LNCS, vol. 13992, 349–370.","chicago":"Henzinger, Thomas A, Nicolas Adrien Mazzocchi, and Naci E Sarac. “Quantitative Safety and Liveness.” In <i>26th International Conference Foundations of Software Science and Computation Structures</i>, 13992:349–70. Springer Nature, 2023. <a href=\"https://doi.org/10.1007/978-3-031-30829-1_17\">https://doi.org/10.1007/978-3-031-30829-1_17</a>.","mla":"Henzinger, Thomas A., et al. “Quantitative Safety and Liveness.” <i>26th International Conference Foundations of Software Science and Computation Structures</i>, vol. 13992, Springer Nature, 2023, pp. 349–70, doi:<a href=\"https://doi.org/10.1007/978-3-031-30829-1_17\">10.1007/978-3-031-30829-1_17</a>.","ama":"Henzinger TA, Mazzocchi NA, Sarac NE. Quantitative safety and liveness. In: <i>26th International Conference Foundations of Software Science and Computation Structures</i>. Vol 13992. Springer Nature; 2023:349-370. doi:<a href=\"https://doi.org/10.1007/978-3-031-30829-1_17\">10.1007/978-3-031-30829-1_17</a>"},"author":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2985-7724","last_name":"Henzinger","full_name":"Henzinger, Thomas A","first_name":"Thomas A"},{"last_name":"Mazzocchi","id":"b26baa86-3308-11ec-87b0-8990f34baa85","full_name":"Mazzocchi, Nicolas Adrien","first_name":"Nicolas Adrien"},{"full_name":"Sarac, Naci E","first_name":"Naci E","last_name":"Sarac","id":"8C6B42F8-C8E6-11E9-A03A-F2DCE5697425"}],"date_updated":"2025-09-09T12:21:08Z","project":[{"call_identifier":"H2020","grant_number":"101020093","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","name":"Vigilant Algorithmic Monitoring of Software"}],"quality_controlled":"1","ec_funded":1,"publication":"26th International Conference Foundations of Software Science and Computation Structures","scopus_import":"1","alternative_title":["LNCS"],"oa":1,"acknowledgement":"We thank the anonymous reviewers for their helpful comments. This work was supported in part by the ERC-2020-AdG 101020093.","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783031308284"]},"status":"public"},{"_id":"12469","date_published":"2023-03-16T00:00:00Z","file_date_updated":"2023-04-17T07:49:09Z","external_id":{"isi":["000961542100001"],"pmid":["37007485"]},"year":"2023","title":"Antiviral immune response reveals host-specific virus infections in natural ant populations","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"type":"journal_article","date_created":"2023-01-31T08:13:40Z","article_processing_charge":"Yes (via OA deal)","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"03","file":[{"file_name":"2023_FrontMicrobiology_Viljakainen.pdf","file_id":"12843","success":1,"date_updated":"2023-04-17T07:49:09Z","relation":"main_file","checksum":"cd52292963acce1111634d9fac08c699","access_level":"open_access","creator":"dernst","date_created":"2023-04-17T07:49:09Z","file_size":4866332,"content_type":"application/pdf"}],"article_type":"original","volume":14,"language":[{"iso":"eng"}],"intvolume":"        14","publication":"Frontiers in Microbiology","scopus_import":"1","publication_identifier":{"eissn":["1664-302X"]},"status":"public","oa":1,"acknowledgement":"We thank D.J. Obbard for sharing the details of the dual RNA-seq/sRNA-seq approach, S.\r\nMetzler and R. Ferrigato for the photographs (Figure 1), M. Konrad, B. Casillas-Perez, C.D.\r\nPull and X. Espadaler for help with ant collection, and the Social Immunity Team at IST\r\nAustria, in particular J. Robb, A. Franschitz, E. Naderlinger, E. Dawson and B. Casillas-Perez\r\nfor support and comments on the manuscript. The study was funded by the Austrian Science\r\nFund (FWF; M02076-B25 to MAF) and the Academy of Finland (343022 to LV). ","author":[{"last_name":"Viljakainen","first_name":"Lumi","full_name":"Viljakainen, Lumi"},{"full_name":"Fürst, Matthias","first_name":"Matthias","last_name":"Fürst","orcid":"0000-0002-3712-925X","id":"393B1196-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Grasse","id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V","first_name":"Anna V"},{"first_name":"Jaana","full_name":"Jurvansuu, Jaana","last_name":"Jurvansuu"},{"orcid":"0000-0001-7425-2372","last_name":"Oh","id":"403169A4-080F-11EA-9993-BF3F3DDC885E","full_name":"Oh, Jinook","first_name":"Jinook"},{"last_name":"Tolonen","full_name":"Tolonen, Lassi","first_name":"Lassi"},{"last_name":"Eder","full_name":"Eder, Thomas","first_name":"Thomas"},{"last_name":"Rattei","first_name":"Thomas","full_name":"Rattei, Thomas"},{"orcid":"0000-0002-2193-3868","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","first_name":"Sylvia"}],"project":[{"call_identifier":"FWF","grant_number":"M02076","_id":"25DF61D8-B435-11E9-9278-68D0E5697425","name":"Viral pathogens and social immunity in ants"}],"date_updated":"2025-04-23T08:54:27Z","citation":{"ama":"Viljakainen L, Fürst M, Grasse AV, et al. Antiviral immune response reveals host-specific virus infections in natural ant populations. <i>Frontiers in Microbiology</i>. 2023;14. doi:<a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">10.3389/fmicb.2023.1119002</a>","mla":"Viljakainen, Lumi, et al. “Antiviral Immune Response Reveals Host-Specific Virus Infections in Natural Ant Populations.” <i>Frontiers in Microbiology</i>, vol. 14, 1119002, Frontiers, 2023, doi:<a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">10.3389/fmicb.2023.1119002</a>.","ista":"Viljakainen L, Fürst M, Grasse AV, Jurvansuu J, Oh J, Tolonen L, Eder T, Rattei T, Cremer S. 2023. Antiviral immune response reveals host-specific virus infections in natural ant populations. Frontiers in Microbiology. 14, 1119002.","chicago":"Viljakainen, Lumi, Matthias Fürst, Anna V Grasse, Jaana Jurvansuu, Jinook Oh, Lassi Tolonen, Thomas Eder, Thomas Rattei, and Sylvia Cremer. “Antiviral Immune Response Reveals Host-Specific Virus Infections in Natural Ant Populations.” <i>Frontiers in Microbiology</i>. Frontiers, 2023. <a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">https://doi.org/10.3389/fmicb.2023.1119002</a>.","ieee":"L. Viljakainen <i>et al.</i>, “Antiviral immune response reveals host-specific virus infections in natural ant populations,” <i>Frontiers in Microbiology</i>, vol. 14. Frontiers, 2023.","apa":"Viljakainen, L., Fürst, M., Grasse, A. V., Jurvansuu, J., Oh, J., Tolonen, L., … Cremer, S. (2023). Antiviral immune response reveals host-specific virus infections in natural ant populations. <i>Frontiers in Microbiology</i>. Frontiers. <a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">https://doi.org/10.3389/fmicb.2023.1119002</a>","short":"L. Viljakainen, M. Fürst, A.V. Grasse, J. Jurvansuu, J. Oh, L. Tolonen, T. Eder, T. Rattei, S. Cremer, Frontiers in Microbiology 14 (2023)."},"publisher":"Frontiers","quality_controlled":"1","pmid":1,"oa_version":"Published Version","publication_status":"published","ddc":["570"],"abstract":[{"text":"Hosts can carry many viruses in their bodies, but not all of them cause disease. We studied ants as a social host to determine both their overall viral repertoire and the subset of actively infecting viruses across natural populations of three subfamilies: the Argentine ant (Linepithema humile, Dolichoderinae), the invasive garden ant (Lasius neglectus, Formicinae) and the red ant (Myrmica rubra, Myrmicinae). We used a dual sequencing strategy to reconstruct complete virus genomes by RNA-seq and to simultaneously determine the small interfering RNAs (siRNAs) by small RNA sequencing (sRNA-seq), which constitute the host antiviral RNAi immune response. This approach led to the discovery of 41 novel viruses in ants and revealed a host ant-specific RNAi response (21 vs. 22 nt siRNAs) in the different ant species. The efficiency of the RNAi response (sRNA/RNA read count ratio) depended on the virus and the respective ant species, but not its population. Overall, we found the highest virus abundance and diversity per population in Li. humile, followed by La. neglectus and M. rubra. Argentine ants also shared a high proportion of viruses between populations, whilst overlap was nearly absent in M. rubra. Only one of the 59 viruses was found to infect two of the ant species as hosts, revealing high host-specificity in active infections. In contrast, six viruses actively infected one ant species, but were found as contaminants only in the others. Disentangling spillover of disease-causing infection from non-infecting contamination across species is providing relevant information for disease ecology and ecosystem management.","lang":"eng"}],"corr_author":"1","has_accepted_license":"1","day":"16","doi":"10.3389/fmicb.2023.1119002","article_number":"1119002","department":[{"_id":"SyCr"}],"isi":1},{"file_date_updated":"2023-07-31T07:16:34Z","external_id":{"pmid":["37485524"],"isi":["001030002600001"]},"year":"2023","title":"Monitoring lineages of growing and dividing bacteria reveals an inducible memory of <i>mar</i> operon expression","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"_id":"12478","date_published":"2023-06-20T00:00:00Z","volume":14,"language":[{"iso":"eng"}],"intvolume":"        14","type":"journal_article","date_created":"2023-02-02T08:13:28Z","article_processing_charge":"Yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","file":[{"date_created":"2023-07-31T07:16:34Z","access_level":"open_access","creator":"dernst","content_type":"application/pdf","file_size":6452841,"checksum":"7dd322347512afaa5daf72a0154f2f07","file_id":"13322","success":1,"relation":"main_file","date_updated":"2023-07-31T07:16:34Z","file_name":"2023_FrontiersMicrobiology_Guet.pdf"}],"month":"06","date_updated":"2024-10-09T21:03:59Z","author":[{"last_name":"Guet","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052","first_name":"Calin C","full_name":"Guet, Calin C"},{"last_name":"Bruneaux","first_name":"L","full_name":"Bruneaux, L"},{"full_name":"Oikonomou, P","first_name":"P","last_name":"Oikonomou"},{"last_name":"Aldana","first_name":"M","full_name":"Aldana, M"},{"first_name":"P","full_name":"Cluzel, P","last_name":"Cluzel"}],"publisher":"Frontiers","citation":{"ama":"Guet CC, Bruneaux L, Oikonomou P, Aldana M, Cluzel P. Monitoring lineages of growing and dividing bacteria reveals an inducible memory of <i>mar</i> operon expression. <i>Frontiers in Microbiology</i>. 2023;14. doi:<a href=\"https://doi.org/10.3389/fmicb.2023.1049255\">10.3389/fmicb.2023.1049255</a>","mla":"Guet, Calin C., et al. “Monitoring Lineages of Growing and Dividing Bacteria Reveals an Inducible Memory of <i>Mar</i> Operon Expression.” <i>Frontiers in Microbiology</i>, vol. 14, 1049255, Frontiers, 2023, doi:<a href=\"https://doi.org/10.3389/fmicb.2023.1049255\">10.3389/fmicb.2023.1049255</a>.","ieee":"C. C. Guet, L. Bruneaux, P. Oikonomou, M. Aldana, and P. Cluzel, “Monitoring lineages of growing and dividing bacteria reveals an inducible memory of <i>mar</i> operon expression,” <i>Frontiers in Microbiology</i>, vol. 14. Frontiers, 2023.","ista":"Guet CC, Bruneaux L, Oikonomou P, Aldana M, Cluzel P. 2023. Monitoring lineages of growing and dividing bacteria reveals an inducible memory of <i>mar</i> operon expression. Frontiers in Microbiology. 14, 1049255.","chicago":"Guet, Calin C, L Bruneaux, P Oikonomou, M Aldana, and P Cluzel. “Monitoring Lineages of Growing and Dividing Bacteria Reveals an Inducible Memory of <i>Mar</i> Operon Expression.” <i>Frontiers in Microbiology</i>. Frontiers, 2023. <a href=\"https://doi.org/10.3389/fmicb.2023.1049255\">https://doi.org/10.3389/fmicb.2023.1049255</a>.","short":"C.C. Guet, L. Bruneaux, P. Oikonomou, M. Aldana, P. Cluzel, Frontiers in Microbiology 14 (2023).","apa":"Guet, C. C., Bruneaux, L., Oikonomou, P., Aldana, M., &#38; Cluzel, P. (2023). Monitoring lineages of growing and dividing bacteria reveals an inducible memory of <i>mar</i> operon expression. <i>Frontiers in Microbiology</i>. Frontiers. <a href=\"https://doi.org/10.3389/fmicb.2023.1049255\">https://doi.org/10.3389/fmicb.2023.1049255</a>"},"quality_controlled":"1","pmid":1,"publication":"Frontiers in Microbiology","scopus_import":"1","status":"public","publication_identifier":{"eissn":["1664-302X"]},"oa":1,"acknowledgement":"This work was supported by NIH P50 award P50GM081892-02 to the University of Chicago, a catalyst grant from the Chicago Biomedical Consortium with support from The Searle Funds at The Chicago Community Trust to PC, and a Yen Fellowship to CCG. MA was partially supported by PAPIIT-UNAM grant IN-11322.","has_accepted_license":"1","day":"20","article_number":"1049255","doi":"10.3389/fmicb.2023.1049255","isi":1,"department":[{"_id":"CaGu"}],"oa_version":"Published Version","ddc":["570"],"publication_status":"published","abstract":[{"text":"In Gram negative bacteria, the multiple antibiotic resistance or mar operon, is known to control the expression of multi-drug efflux genes that protect bacteria from a wide range of drugs. As many different chemical compounds can induce this operon, identifying the parameters that govern the dynamics of its induction is crucial to better characterize the processes of tolerance and resistance. Most experiments have assumed that the properties of the mar transcriptional network can be inferred from population measurements. However, measurements from an asynchronous population of cells can mask underlying phenotypic variations of single cells. We monitored the activity of the mar promoter in single Escherichia coli cells in linear micro-colonies and established that the response to a steady level of inducer was most heterogeneous within individual colonies for an intermediate value of inducer. Specifically, sub-lineages defined by contiguous daughter-cells exhibited similar promoter activity, whereas activity was greatly variable between different sub-lineages. Specific sub-trees of uniform promoter activity persisted over several generations. Statistical analyses of the lineages suggest that the presence of these sub-trees is the signature of an inducible memory of the promoter state that is transmitted from mother to daughter cells. This single-cell study reveals that the degree of epigenetic inheritance changes as a function of inducer concentration, suggesting that phenotypic inheritance may be an inducible phenotype.","lang":"eng"}],"corr_author":"1"},{"pmid":1,"ec_funded":1,"quality_controlled":"1","publisher":"Elsevier","citation":{"ama":"Scarpetta S, Morrisi N, Mutti C, et al. Criticality of neuronal avalanches in human sleep and their relationship with sleep macro- and micro-architecture. <i>iScience</i>. 2023;26(10):107840. doi:<a href=\"https://doi.org/10.1016/j.isci.2023.107840\">10.1016/j.isci.2023.107840</a>","mla":"Scarpetta, Silvia, et al. “Criticality of Neuronal Avalanches in Human Sleep and Their Relationship with Sleep Macro- and Micro-Architecture.” <i>IScience</i>, vol. 26, no. 10, Elsevier, 2023, p. 107840, doi:<a href=\"https://doi.org/10.1016/j.isci.2023.107840\">10.1016/j.isci.2023.107840</a>.","ieee":"S. Scarpetta <i>et al.</i>, “Criticality of neuronal avalanches in human sleep and their relationship with sleep macro- and micro-architecture,” <i>iScience</i>, vol. 26, no. 10. Elsevier, p. 107840, 2023.","ista":"Scarpetta S, Morrisi N, Mutti C, Azzi N, Trippi I, Ciliento R, Apicella I, Messuti G, Angiolelli M, Lombardi F, Parrino L, Vaudano AE. 2023. Criticality of neuronal avalanches in human sleep and their relationship with sleep macro- and micro-architecture. iScience. 26(10), 107840.","chicago":"Scarpetta, Silvia, Niccolò Morrisi, Carlotta Mutti, Nicoletta Azzi, Irene Trippi, Rosario Ciliento, Ilenia Apicella, et al. “Criticality of Neuronal Avalanches in Human Sleep and Their Relationship with Sleep Macro- and Micro-Architecture.” <i>IScience</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.isci.2023.107840\">https://doi.org/10.1016/j.isci.2023.107840</a>.","apa":"Scarpetta, S., Morrisi, N., Mutti, C., Azzi, N., Trippi, I., Ciliento, R., … Vaudano, A. E. (2023). Criticality of neuronal avalanches in human sleep and their relationship with sleep macro- and micro-architecture. <i>IScience</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.isci.2023.107840\">https://doi.org/10.1016/j.isci.2023.107840</a>","short":"S. Scarpetta, N. Morrisi, C. Mutti, N. Azzi, I. Trippi, R. Ciliento, I. Apicella, G. Messuti, M. Angiolelli, F. Lombardi, L. Parrino, A.E. Vaudano, IScience 26 (2023) 107840."},"author":[{"last_name":"Scarpetta","first_name":"Silvia","full_name":"Scarpetta, Silvia"},{"first_name":"Niccolò","full_name":"Morrisi, Niccolò","last_name":"Morrisi"},{"first_name":"Carlotta","full_name":"Mutti, Carlotta","last_name":"Mutti"},{"first_name":"Nicoletta","full_name":"Azzi, Nicoletta","last_name":"Azzi"},{"first_name":"Irene","full_name":"Trippi, Irene","last_name":"Trippi"},{"last_name":"Ciliento","first_name":"Rosario","full_name":"Ciliento, Rosario"},{"last_name":"Apicella","full_name":"Apicella, Ilenia","first_name":"Ilenia"},{"last_name":"Messuti","first_name":"Giovanni","full_name":"Messuti, Giovanni"},{"last_name":"Angiolelli","first_name":"Marianna","full_name":"Angiolelli, Marianna"},{"orcid":"0000-0003-2623-5249","last_name":"Lombardi","id":"A057D288-3E88-11E9-986D-0CF4E5697425","full_name":"Lombardi, Fabrizio","first_name":"Fabrizio"},{"last_name":"Parrino","full_name":"Parrino, Liborio","first_name":"Liborio"},{"last_name":"Vaudano","first_name":"Anna Elisabetta","full_name":"Vaudano, Anna Elisabetta"}],"project":[{"call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"},{"grant_number":"M03318","name":"Functional Advantages of Critical Brain Dynamics","_id":"eb943429-77a9-11ec-83b8-9f471cdf5c67"}],"date_updated":"2025-04-14T07:44:00Z","oa":1,"acknowledgement":"FL acknowledges support from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement No. 754411, and from the Austrian Science Fund (FWF) under the Lise Meitner fellowship No. PT1013M03318. IA acknowledges financial support from the MIUR PRIN 2017WZFTZP.","publication_identifier":{"eissn":["2589-0042"]},"status":"public","scopus_import":"1","publication":"iScience","department":[{"_id":"GaTk"}],"isi":1,"doi":"10.1016/j.isci.2023.107840","day":"20","has_accepted_license":"1","page":"107840","abstract":[{"lang":"eng","text":"Sleep plays a key role in preserving brain function, keeping the brain network in a state that ensures optimal computational capabilities. Empirical evidence indicates that such a state is consistent with criticality, where scale-free neuronal avalanches emerge. However, the relationship between sleep, emergent avalanches, and criticality remains poorly understood. Here we fully characterize the critical behavior of avalanches during sleep, and study their relationship with the sleep macro- and micro-architecture, in particular the cyclic alternating pattern (CAP). We show that avalanche size and duration distributions exhibit robust power laws with exponents approximately equal to −3/2 e −2, respectively. Importantly, we find that sizes scale as a power law of the durations, and that all critical exponents for neuronal avalanches obey robust scaling relations, which are consistent with the mean-field directed percolation universality class. Our analysis demonstrates that avalanche dynamics depends on the position within the NREM-REM cycles, with the avalanche density increasing in the descending phases and decreasing in the ascending phases of sleep cycles. Moreover, we show that, within NREM sleep, avalanche occurrence correlates with CAP activation phases, particularly A1, which are the expression of slow wave sleep propensity and have been proposed to be beneficial for cognitive processes. The results suggest that neuronal avalanches, and thus tuning to criticality, actively contribute to sleep development and play a role in preserving network function. Such findings, alongside characterization of the universality class for avalanches, open new avenues to the investigation of functional role of criticality during sleep with potential clinical application.</jats:p><jats:sec><jats:title>Significance statement</jats:title><jats:p>We fully characterize the critical behavior of neuronal avalanches during sleep, and show that avalanches follow precise scaling laws that are consistent with the mean-field directed percolation universality class. The analysis provides first evidence of a functional relationship between avalanche occurrence, slow-wave sleep dynamics, sleep stage transitions and occurrence of CAP phase A during NREM sleep. Because CAP is considered one of the major guardians of NREM sleep that allows the brain to dynamically react to external perturbation and contributes to the cognitive consolidation processes occurring in sleep, our observations suggest that neuronal avalanches at criticality are associated with flexible response to external inputs and to cognitive processes, a key assumption of the critical brain hypothesis."}],"publication_status":"published","ddc":["570"],"oa_version":"Published Version","title":"Criticality of neuronal avalanches in human sleep and their relationship with sleep macro- and micro-architecture","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2023","external_id":{"isi":["001082331200001"],"pmid":["37766992"]},"file_date_updated":"2023-10-09T07:23:46Z","date_published":"2023-10-20T00:00:00Z","_id":"12487","intvolume":"        26","language":[{"iso":"eng"}],"volume":26,"issue":"10","file":[{"file_name":"2023_iScience_Scarpetta.pdf","relation":"main_file","date_updated":"2023-10-09T07:23:46Z","file_id":"14412","success":1,"checksum":"f499836af172ecc9865de4bb41fa99d1","content_type":"application/pdf","file_size":4872708,"access_level":"open_access","creator":"dernst","date_created":"2023-10-09T07:23:46Z"}],"month":"10","article_type":"original","article_processing_charge":"Yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-02-02T10:50:17Z","type":"journal_article"},{"department":[{"_id":"GradSch"},{"_id":"PaSc"}],"doi":"10.15479/AT:ISTA:12497","has_accepted_license":"1","day":"23","corr_author":"1","abstract":[{"lang":"eng","text":"Aromatic side chains are important reporters of the plasticity of proteins, and often form important contacts in protein–protein interactions. We studied aromatic residues in the two structurally homologous cross-β amyloid fibrils HET-s, and  HELLF by employing a specific isotope-labeling approach and magic-angle-spinning NMR. The dynamic behavior of the aromatic residues Phe and Tyr indicates that the hydrophobic amyloid core is rigid, without any sign of \"breathing motions\" over hundreds of milliseconds at least. Aromatic residues exposed at the fibril surface have a rigid ring axis but undergo ring flips on a variety of time scales from nanoseconds to microseconds. Our approach provides direct insight into hydrophobic-core motions, enabling a better evaluation of the conformational heterogeneity generated from an NMR structural ensemble of such amyloid cross-β architecture."}],"month":"03","file":[{"file_id":"12743","date_updated":"2023-03-24T09:34:20Z","relation":"main_file","file_name":"Research_Data.zip","date_created":"2023-03-23T10:03:16Z","access_level":"open_access","creator":"lbecker","file_size":87018103,"content_type":"application/zip","checksum":"fd9a28620a81a82991fb70f4fd6591d9"},{"creator":"dernst","date_created":"2023-03-24T07:13:55Z","access_level":"open_access","content_type":"text/plain","file_size":747,"checksum":"30ebdfb600af118fcf8518b6efe0b7e9","file_id":"12755","relation":"main_file","date_updated":"2023-03-24T09:42:03Z","file_name":"README.txt"}],"ddc":["572"],"keyword":["aromatic side chains","isotopic labeling","protein dynamics","ring flips","spin relaxation"],"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","date_created":"2023-02-03T08:08:02Z","type":"research_data","contributor":[{"first_name":"Mélanie","last_name":"Berbon","contributor_type":"researcher"},{"first_name":"Alicia","contributor_type":"researcher","last_name":"Vallet"},{"contributor_type":"researcher","last_name":"Grelard","first_name":"Axelle"},{"first_name":"Estelle","last_name":"Morvan","contributor_type":"researcher"},{"contributor_type":"researcher","last_name":"Bardiaux","first_name":"Benjamin"},{"contributor_type":"researcher","last_name":"Lichtenecker","first_name":"Roman"},{"first_name":"Matthias","last_name":"Ernst","contributor_type":"researcher"},{"first_name":"Antoine","last_name":"Loquet","contributor_type":"researcher"},{"last_name":"Schanda","orcid":"0000-0002-9350-7606","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","contributor_type":"contact_person","first_name":"Paul"},{"contributor_type":"researcher","orcid":"0000-0002-6401-5151","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","last_name":"Becker","first_name":"Lea Marie"}],"title":"Research data to: The rigid core and flexible surface of amyloid fibrils probed by magic-angle-spinning NMR spectroscopy of aromatic residues","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"year":"2023","publisher":"Institute of Science and Technology Austria","citation":{"ieee":"L. M. Becker and P. Schanda, “Research data to: The rigid core and flexible surface of amyloid fibrils probed by magic-angle-spinning NMR spectroscopy of aromatic residues.” Institute of Science and Technology Austria, 2023.","ista":"Becker LM, Schanda P. 2023. Research data to: The rigid core and flexible surface of amyloid fibrils probed by magic-angle-spinning NMR spectroscopy of aromatic residues, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:12497\">10.15479/AT:ISTA:12497</a>.","chicago":"Becker, Lea Marie, and Paul Schanda. “Research Data to: The Rigid Core and Flexible Surface of Amyloid Fibrils Probed by Magic-Angle-Spinning NMR Spectroscopy of Aromatic Residues.” Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/AT:ISTA:12497\">https://doi.org/10.15479/AT:ISTA:12497</a>.","short":"L.M. Becker, P. Schanda, (2023).","apa":"Becker, L. M., &#38; Schanda, P. (2023). Research data to: The rigid core and flexible surface of amyloid fibrils probed by magic-angle-spinning NMR spectroscopy of aromatic residues. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:12497\">https://doi.org/10.15479/AT:ISTA:12497</a>","ama":"Becker LM, Schanda P. Research data to: The rigid core and flexible surface of amyloid fibrils probed by magic-angle-spinning NMR spectroscopy of aromatic residues. 2023. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12497\">10.15479/AT:ISTA:12497</a>","mla":"Becker, Lea Marie, and Paul Schanda. <i>Research Data to: The Rigid Core and Flexible Surface of Amyloid Fibrils Probed by Magic-Angle-Spinning NMR Spectroscopy of Aromatic Residues</i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12497\">10.15479/AT:ISTA:12497</a>."},"related_material":{"record":[{"id":"12675","status":"public","relation":"used_in_publication"}]},"date_updated":"2024-10-21T06:01:38Z","file_date_updated":"2023-03-24T09:42:03Z","author":[{"full_name":"Becker, Lea Marie","first_name":"Lea Marie","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","orcid":"0000-0002-6401-5151","last_name":"Becker"},{"last_name":"Schanda","orcid":"0000-0002-9350-7606","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","first_name":"Paul","full_name":"Schanda, Paul"}],"oa":1,"status":"public","date_published":"2023-03-23T00:00:00Z","_id":"12497"},{"title":"A multivariate view of the speciation continuum","year":"2023","external_id":{"isi":["001021686300024"],"pmid":["36622661"]},"date_published":"2023-01-01T00:00:00Z","_id":"12514","language":[{"iso":"eng"}],"intvolume":"        77","volume":77,"issue":"1","main_file_link":[{"url":"https://doi.org/10.1093/evolut/qpac004","open_access":"1"}],"month":"01","article_type":"original","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-02-05T23:00:59Z","type":"journal_article","pmid":1,"quality_controlled":"1","publisher":"Oxford University Press","citation":{"chicago":"Bolnick, Daniel I., Amanda K. Hund, Patrik Nosil, Foen Peng, Mark Ravinet, Sean Stankowski, Swapna Subramanian, Jochen B.W. Wolf, and Roman Yukilevich. “A Multivariate View of the Speciation Continuum.” <i>Evolution: International Journal of Organic Evolution</i>. Oxford University Press, 2023. <a href=\"https://doi.org/10.1093/evolut/qpac004\">https://doi.org/10.1093/evolut/qpac004</a>.","ieee":"D. I. Bolnick <i>et al.</i>, “A multivariate view of the speciation continuum,” <i>Evolution: International journal of organic evolution</i>, vol. 77, no. 1. Oxford University Press, pp. 318–328, 2023.","ista":"Bolnick DI, Hund AK, Nosil P, Peng F, Ravinet M, Stankowski S, Subramanian S, Wolf JBW, Yukilevich R. 2023. A multivariate view of the speciation continuum. Evolution: International journal of organic evolution. 77(1), 318–328.","short":"D.I. Bolnick, A.K. Hund, P. Nosil, F. Peng, M. Ravinet, S. Stankowski, S. Subramanian, J.B.W. Wolf, R. Yukilevich, Evolution: International Journal of Organic Evolution 77 (2023) 318–328.","apa":"Bolnick, D. I., Hund, A. K., Nosil, P., Peng, F., Ravinet, M., Stankowski, S., … Yukilevich, R. (2023). A multivariate view of the speciation continuum. <i>Evolution: International Journal of Organic Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/evolut/qpac004\">https://doi.org/10.1093/evolut/qpac004</a>","ama":"Bolnick DI, Hund AK, Nosil P, et al. A multivariate view of the speciation continuum. <i>Evolution: International journal of organic evolution</i>. 2023;77(1):318-328. doi:<a href=\"https://doi.org/10.1093/evolut/qpac004\">10.1093/evolut/qpac004</a>","mla":"Bolnick, Daniel I., et al. “A Multivariate View of the Speciation Continuum.” <i>Evolution: International Journal of Organic Evolution</i>, vol. 77, no. 1, Oxford University Press, 2023, pp. 318–28, doi:<a href=\"https://doi.org/10.1093/evolut/qpac004\">10.1093/evolut/qpac004</a>."},"date_updated":"2026-06-18T17:26:56Z","author":[{"last_name":"Bolnick","first_name":"Daniel I.","full_name":"Bolnick, Daniel I."},{"last_name":"Hund","first_name":"Amanda K.","full_name":"Hund, Amanda K."},{"first_name":"Patrik","full_name":"Nosil, Patrik","last_name":"Nosil"},{"first_name":"Foen","full_name":"Peng, Foen","last_name":"Peng"},{"last_name":"Ravinet","first_name":"Mark","full_name":"Ravinet, Mark"},{"last_name":"Stankowski","id":"43161670-5719-11EA-8025-FABC3DDC885E","full_name":"Stankowski, Sean","first_name":"Sean"},{"full_name":"Subramanian, Swapna","first_name":"Swapna","last_name":"Subramanian"},{"full_name":"Wolf, Jochen B.W.","first_name":"Jochen B.W.","last_name":"Wolf"},{"first_name":"Roman","full_name":"Yukilevich, Roman","last_name":"Yukilevich"}],"acknowledgement":"The authors of this article were supported by LMU Munich (J.B.W.W.), a James S. McDonnell Foundation postdoctoral fellowship (A.K.H.). P.N. received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant agreement No. 770826 EE-Dynamics).\r\nWe thank participants in the 2019 Gordon Conference on Speciation for the extensive conversation on this topic. Thanks to Dan Funk for providing permission to use data from Funk et al. 2006, and for comments on the manuscript.","oa":1,"publication_identifier":{"eissn":["1558-5646"]},"status":"public","publication":"Evolution: International journal of organic evolution","scopus_import":"1","department":[{"_id":"NiBa"}],"isi":1,"doi":"10.1093/evolut/qpac004","day":"01","page":"318-328","abstract":[{"text":"The concept of a “speciation continuum” has gained popularity in recent decades. It emphasizes speciation as a continuous process that may be studied by comparing contemporary population pairs that show differing levels of divergence. In their recent perspective article in Evolution, Stankowski and Ravinet provided a valuable service by formally defining the speciation continuum as a continuum of reproductive isolation, based on opinions gathered from a survey of speciation researchers. While we agree that the speciation continuum has been a useful concept to advance the understanding of the speciation process, some intrinsic limitations exist. Here, we advocate for a multivariate extension, the speciation hypercube, first proposed by Dieckmann et al. in 2004, but rarely used since. We extend the idea of the speciation cube and suggest it has strong conceptual and practical advantages over a one-dimensional model. We illustrate how the speciation hypercube can be used to visualize and compare different speciation trajectories, providing new insights into the processes and mechanisms of speciation. A key strength of the speciation hypercube is that it provides a unifying framework for speciation research, as it allows questions from apparently disparate subfields to be addressed in a single conceptual model.","lang":"eng"}],"publication_status":"published","ddc":["570"],"oa_version":"Published Version"},{"year":"2023","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"The olfactory limbus of the red fox (Vulpes vulpes). New insights regarding a noncanonical olfactory bulb pathway","file_date_updated":"2023-02-06T07:56:14Z","external_id":{"isi":["000919786900001"],"pmid":["36704406"]},"_id":"12515","date_published":"2023-01-10T00:00:00Z","volume":16,"language":[{"iso":"eng"}],"intvolume":"        16","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","file":[{"file_name":"2022_FrontiersNeuroanatomy_OrtizLeal.pdf","relation":"main_file","date_updated":"2023-02-06T07:56:14Z","file_id":"12518","success":1,"checksum":"49cd40f3bda6f267079427042e7d15e3","content_type":"application/pdf","file_size":21943473,"creator":"dernst","access_level":"open_access","date_created":"2023-02-06T07:56:14Z"}],"month":"01","type":"journal_article","date_created":"2023-02-05T23:01:00Z","quality_controlled":"1","pmid":1,"date_updated":"2023-08-16T11:37:52Z","author":[{"first_name":"Irene","full_name":"Ortiz-Leal, Irene","last_name":"Ortiz-Leal"},{"last_name":"Torres","first_name":"Mateo V.","full_name":"Torres, Mateo V."},{"last_name":"Vargas Barroso","id":"2F55A9DE-F248-11E8-B48F-1D18A9856A87","first_name":"Victor M","full_name":"Vargas Barroso, Victor M"},{"first_name":"Luis Eusebio","full_name":"Fidalgo, Luis Eusebio","last_name":"Fidalgo"},{"last_name":"López-Beceiro","full_name":"López-Beceiro, Ana María","first_name":"Ana María"},{"last_name":"Larriva-Sahd","full_name":"Larriva-Sahd, Jorge A.","first_name":"Jorge A."},{"last_name":"Sánchez-Quinteiro","first_name":"Pablo","full_name":"Sánchez-Quinteiro, Pablo"}],"publisher":"Frontiers","citation":{"ieee":"I. Ortiz-Leal <i>et al.</i>, “The olfactory limbus of the red fox (Vulpes vulpes). New insights regarding a noncanonical olfactory bulb pathway,” <i>Frontiers in Neuroanatomy</i>, vol. 16. Frontiers, 2023.","ista":"Ortiz-Leal I, Torres MV, Vargas Barroso VM, Fidalgo LE, López-Beceiro AM, Larriva-Sahd JA, Sánchez-Quinteiro P. 2023. The olfactory limbus of the red fox (Vulpes vulpes). New insights regarding a noncanonical olfactory bulb pathway. Frontiers in Neuroanatomy. 16, 1097467.","chicago":"Ortiz-Leal, Irene, Mateo V. Torres, Victor M Vargas Barroso, Luis Eusebio Fidalgo, Ana María López-Beceiro, Jorge A. Larriva-Sahd, and Pablo Sánchez-Quinteiro. “The Olfactory Limbus of the Red Fox (Vulpes Vulpes). New Insights Regarding a Noncanonical Olfactory Bulb Pathway.” <i>Frontiers in Neuroanatomy</i>. Frontiers, 2023. <a href=\"https://doi.org/10.3389/fnana.2022.1097467\">https://doi.org/10.3389/fnana.2022.1097467</a>.","short":"I. Ortiz-Leal, M.V. Torres, V.M. Vargas Barroso, L.E. Fidalgo, A.M. López-Beceiro, J.A. Larriva-Sahd, P. Sánchez-Quinteiro, Frontiers in Neuroanatomy 16 (2023).","apa":"Ortiz-Leal, I., Torres, M. V., Vargas Barroso, V. M., Fidalgo, L. E., López-Beceiro, A. M., Larriva-Sahd, J. A., &#38; Sánchez-Quinteiro, P. (2023). The olfactory limbus of the red fox (Vulpes vulpes). New insights regarding a noncanonical olfactory bulb pathway. <i>Frontiers in Neuroanatomy</i>. Frontiers. <a href=\"https://doi.org/10.3389/fnana.2022.1097467\">https://doi.org/10.3389/fnana.2022.1097467</a>","ama":"Ortiz-Leal I, Torres MV, Vargas Barroso VM, et al. The olfactory limbus of the red fox (Vulpes vulpes). New insights regarding a noncanonical olfactory bulb pathway. <i>Frontiers in Neuroanatomy</i>. 2023;16. doi:<a href=\"https://doi.org/10.3389/fnana.2022.1097467\">10.3389/fnana.2022.1097467</a>","mla":"Ortiz-Leal, Irene, et al. “The Olfactory Limbus of the Red Fox (Vulpes Vulpes). New Insights Regarding a Noncanonical Olfactory Bulb Pathway.” <i>Frontiers in Neuroanatomy</i>, vol. 16, 1097467, Frontiers, 2023, doi:<a href=\"https://doi.org/10.3389/fnana.2022.1097467\">10.3389/fnana.2022.1097467</a>."},"publication_identifier":{"eissn":["1662-5129"]},"status":"public","oa":1,"acknowledgement":"This work was partially supported by a grant from “Consello Social Universidade de Santiago de Compostela” 2022-PU004.We would like to show special gratitude to Prof. Ludwig Wagner (Medical University, Vienna) for kindly providing us with the secretagogin antibody. We thank the Wildlife Recovery Centres of Galicia, Dirección Xeral de Patrimonio Natural (Xunta de Galicia, Spain), and Federación Galega de Caza for providing the red foxes used in this study.","publication":"Frontiers in Neuroanatomy","scopus_import":"1","department":[{"_id":"PeJo"}],"isi":1,"has_accepted_license":"1","day":"10","doi":"10.3389/fnana.2022.1097467","article_number":"1097467","publication_status":"published","ddc":["570"],"abstract":[{"lang":"eng","text":"Introduction: The olfactory system in most mammals is divided into several subsystems based on the anatomical locations of the neuroreceptor cells involved and the receptor families that are expressed. In addition to the main olfactory system and the vomeronasal system, a range of olfactory subsystems converge onto the transition zone located between the main olfactory bulb (MOB) and the accessory olfactory bulb (AOB), which has been termed the olfactory limbus (OL). The OL contains specialized glomeruli that receive noncanonical sensory afferences and which interact with the MOB and AOB. Little is known regarding the olfactory subsystems of mammals other than laboratory rodents.\r\nMethods: We have focused on characterizing the OL in the red fox by performing general and specific histological stainings on serial sections, using both single and double immunohistochemical and lectin-histochemical labeling techniques.\r\nResults: As a result, we have been able to determine that the OL of the red fox (Vulpes vulpes) displays an uncommonly high degree of development and complexity.\r\nDiscussion: This makes this species a novel mammalian model, the study of which could improve our understanding of the noncanonical pathways involved in the processing of chemosensory cues."}],"oa_version":"Published Version"},{"date_updated":"2025-04-14T07:48:54Z","project":[{"name":"Angulon: physics and applications of a new quasiparticle","_id":"2688CF98-B435-11E9-9278-68D0E5697425","grant_number":"801770","call_identifier":"H2020"}],"author":[{"orcid":"0000-0001-9666-3543","id":"4AF46FD6-F248-11E8-B48F-1D18A9856A87","last_name":"Ghazaryan","full_name":"Ghazaryan, Areg","first_name":"Areg"},{"id":"9d13b3cb-30a2-11eb-80dc-f772505e8660","orcid":"0000-0001-6110-2359","last_name":"Cappellaro","first_name":"Alberto","full_name":"Cappellaro, Alberto"},{"first_name":"Mikhail","full_name":"Lemeshko, Mikhail","orcid":"0000-0002-6990-7802","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","last_name":"Lemeshko"},{"first_name":"Artem","full_name":"Volosniev, Artem","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","last_name":"Volosniev","orcid":"0000-0003-0393-5525"}],"publisher":"American Physical Society","citation":{"ieee":"A. Ghazaryan, A. Cappellaro, M. Lemeshko, and A. Volosniev, “Dissipative dynamics of an impurity with spin-orbit coupling,” <i>Physical Review Research</i>, vol. 5, no. 1. American Physical Society, 2023.","chicago":"Ghazaryan, Areg, Alberto Cappellaro, Mikhail Lemeshko, and Artem Volosniev. “Dissipative Dynamics of an Impurity with Spin-Orbit Coupling.” <i>Physical Review Research</i>. American Physical Society, 2023. <a href=\"https://doi.org/10.1103/physrevresearch.5.013029\">https://doi.org/10.1103/physrevresearch.5.013029</a>.","ista":"Ghazaryan A, Cappellaro A, Lemeshko M, Volosniev A. 2023. Dissipative dynamics of an impurity with spin-orbit coupling. Physical Review Research. 5(1), 013029.","apa":"Ghazaryan, A., Cappellaro, A., Lemeshko, M., &#38; Volosniev, A. (2023). Dissipative dynamics of an impurity with spin-orbit coupling. <i>Physical Review Research</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevresearch.5.013029\">https://doi.org/10.1103/physrevresearch.5.013029</a>","short":"A. Ghazaryan, A. Cappellaro, M. Lemeshko, A. Volosniev, Physical Review Research 5 (2023).","ama":"Ghazaryan A, Cappellaro A, Lemeshko M, Volosniev A. Dissipative dynamics of an impurity with spin-orbit coupling. <i>Physical Review Research</i>. 2023;5(1). doi:<a href=\"https://doi.org/10.1103/physrevresearch.5.013029\">10.1103/physrevresearch.5.013029</a>","mla":"Ghazaryan, Areg, et al. “Dissipative Dynamics of an Impurity with Spin-Orbit Coupling.” <i>Physical Review Research</i>, vol. 5, no. 1, 013029, American Physical Society, 2023, doi:<a href=\"https://doi.org/10.1103/physrevresearch.5.013029\">10.1103/physrevresearch.5.013029</a>."},"ec_funded":1,"quality_controlled":"1","publication":"Physical Review Research","scopus_import":"1","publication_identifier":{"issn":["2643-1564"]},"status":"public","acknowledgement":"We thank Rafael Barfknecht for help at the initial stages of this project; Fabian Brauneis for useful discussions; Miguel A. Garcia-March, Georgios Koutentakis, and Simeon Mistakidis\r\nfor comments on the paper. M.L. acknowledges support by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON).","oa":1,"has_accepted_license":"1","day":"20","doi":"10.1103/physrevresearch.5.013029","article_number":"013029","department":[{"_id":"MiLe"}],"oa_version":"Published Version","publication_status":"published","ddc":["530"],"corr_author":"1","abstract":[{"lang":"eng","text":"Brownian motion of a mobile impurity in a bath is affected by spin-orbit coupling (SOC). Here, we discuss a Caldeira-Leggett-type model that can be used to propose and interpret quantum simulators of this problem in cold Bose gases. First, we derive a master equation that describes the model and explore it in a one-dimensional (1D) setting. To validate the standard assumptions needed for our derivation, we analyze available experimental data without SOC; as a byproduct, this analysis suggests that the quench dynamics of the impurity is beyond the 1D Bose-polaron approach at temperatures currently accessible in a cold-atom laboratory—motion of the impurity is mainly driven by dissipation. For systems with SOC, we demonstrate that 1D spin-orbit coupling can be gauged out even in the presence of dissipation—the information about SOC is incorporated in the initial conditions. Observables sensitive to this information (such as spin densities) can be used to study formation of steady spin polarization domains during quench dynamics."}],"file_date_updated":"2023-02-13T10:38:10Z","year":"2023","title":"Dissipative dynamics of an impurity with spin-orbit coupling","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"_id":"12534","date_published":"2023-01-20T00:00:00Z","issue":"1","volume":5,"language":[{"iso":"eng"}],"intvolume":"         5","type":"journal_article","date_created":"2023-02-10T09:02:26Z","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","file":[{"content_type":"application/pdf","file_size":865150,"creator":"dernst","date_created":"2023-02-13T10:38:10Z","access_level":"open_access","checksum":"6068b62874c0099628a108bb9c5c6bd2","relation":"main_file","date_updated":"2023-02-13T10:38:10Z","file_id":"12546","success":1,"file_name":"2023_PhysicalReviewResearch_Ghazaryan.pdf"}],"month":"01"},{"pmid":1,"quality_controlled":"1","publisher":"Elsevier","citation":{"ama":"Villalba Requena A, Hippenmeyer S. Going back in time with TEMPO. <i>Neuron</i>. 2023;111(3):291-293. doi:<a href=\"https://doi.org/10.1016/j.neuron.2023.01.006\">10.1016/j.neuron.2023.01.006</a>","mla":"Villalba Requena, Ana, and Simon Hippenmeyer. “Going Back in Time with TEMPO.” <i>Neuron</i>, vol. 111, no. 3, Elsevier, 2023, pp. 291–93, doi:<a href=\"https://doi.org/10.1016/j.neuron.2023.01.006\">10.1016/j.neuron.2023.01.006</a>.","ieee":"A. Villalba Requena and S. Hippenmeyer, “Going back in time with TEMPO,” <i>Neuron</i>, vol. 111, no. 3. Elsevier, pp. 291–293, 2023.","chicago":"Villalba Requena, Ana, and Simon Hippenmeyer. “Going Back in Time with TEMPO.” <i>Neuron</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.neuron.2023.01.006\">https://doi.org/10.1016/j.neuron.2023.01.006</a>.","ista":"Villalba Requena A, Hippenmeyer S. 2023. Going back in time with TEMPO. Neuron. 111(3), 291–293.","short":"A. Villalba Requena, S. Hippenmeyer, Neuron 111 (2023) 291–293.","apa":"Villalba Requena, A., &#38; Hippenmeyer, S. (2023). Going back in time with TEMPO. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2023.01.006\">https://doi.org/10.1016/j.neuron.2023.01.006</a>"},"author":[{"full_name":"Villalba Requena, Ana","first_name":"Ana","last_name":"Villalba Requena","orcid":"0000-0002-5615-5277","id":"68cb85a0-39f7-11eb-9559-9aaab4f6a247"},{"id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer","first_name":"Simon","full_name":"Hippenmeyer, Simon"}],"date_updated":"2026-06-18T17:27:44Z","oa":1,"OA_type":"free access","status":"public","publication_identifier":{"eissn":["1097-4199"]},"scopus_import":"1","publication":"Neuron","isi":1,"department":[{"_id":"SiHi"}],"doi":"10.1016/j.neuron.2023.01.006","day":"01","corr_author":"1","abstract":[{"text":"In this issue of Neuron, Espinosa-Medina et al.1 present the TEMPO (Temporal Encoding and Manipulation in a Predefined Order) system, which enables the marking and genetic manipulation of sequentially generated cell lineages in vertebrate species in vivo.","lang":"eng"}],"page":"291-293","ddc":["570"],"publication_status":"published","oa_version":"Published Version","title":"Going back in time with TEMPO","year":"2023","external_id":{"pmid":["36731425"],"isi":["000994473300001"]},"date_published":"2023-02-01T00:00:00Z","_id":"12542","intvolume":"       111","language":[{"iso":"eng"}],"volume":111,"issue":"3","OA_place":"publisher","main_file_link":[{"url":"https://doi.org/10.1016/j.neuron.2023.01.006","open_access":"1"}],"month":"02","article_type":"letter_note","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-02-12T23:00:58Z","type":"journal_article"},{"date_published":"2023-03-01T00:00:00Z","_id":"12543","acknowledged_ssus":[{"_id":"LifeSc"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"Pathogen evasion of social immunity","year":"2023","external_id":{"pmid":["36732670"],"isi":["000924572800001"]},"file_date_updated":"2023-08-16T11:54:59Z","file":[{"content_type":"application/pdf","file_size":1600499,"date_created":"2023-08-16T11:54:59Z","access_level":"open_access","creator":"dernst","checksum":"8244f4650a0e7aeea488d1bcd4a31702","relation":"main_file","date_updated":"2023-08-16T11:54:59Z","success":1,"file_id":"14069","file_name":"2023_NatureEcoEvo_Stock.pdf"}],"article_type":"original","month":"03","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","date_created":"2023-02-12T23:00:59Z","type":"journal_article","language":[{"iso":"eng"}],"intvolume":"         7","volume":7,"acknowledgement":"We thank B. M. Steinwender, N. V. Meyling and J. Eilenberg for the fungal strains; J. Anaya-Rojas for statistical advice; the Social Immunity team at ISTA for ant collection and experimental help, in particular H. Leitner, and the ISTA Lab Support Facility for general laboratory support; D. Ebert, H. Schulenburg and J. Heinze for continued project discussion; and M. Sixt, R. Roemhild and the Social Immunity team for comments on the manuscript. The study was funded by the German Research Foundation (CR118/3-1) within the Framework of the Priority Program SPP 1399, and the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (No. 771402; EPIDEMICSonCHIP), both to S.C.","oa":1,"status":"public","publication_identifier":{"eissn":["2397-334X"]},"scopus_import":"1","publication":"Nature Ecology and Evolution","pmid":1,"quality_controlled":"1","ec_funded":1,"citation":{"short":"M. Stock, B. Milutinovic, M. Hönigsberger, A.V. Grasse, F. Wiesenhofer, N. Kampleitner, M. Narasimhan, T. Schmitt, S. Cremer, Nature Ecology and Evolution 7 (2023) 450–460.","apa":"Stock, M., Milutinovic, B., Hönigsberger, M., Grasse, A. V., Wiesenhofer, F., Kampleitner, N., … Cremer, S. (2023). Pathogen evasion of social immunity. <i>Nature Ecology and Evolution</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41559-023-01981-6\">https://doi.org/10.1038/s41559-023-01981-6</a>","ista":"Stock M, Milutinovic B, Hönigsberger M, Grasse AV, Wiesenhofer F, Kampleitner N, Narasimhan M, Schmitt T, Cremer S. 2023. Pathogen evasion of social immunity. Nature Ecology and Evolution. 7, 450–460.","ieee":"M. Stock <i>et al.</i>, “Pathogen evasion of social immunity,” <i>Nature Ecology and Evolution</i>, vol. 7. Springer Nature, pp. 450–460, 2023.","chicago":"Stock, Miriam, Barbara Milutinovic, Michaela Hönigsberger, Anna V Grasse, Florian Wiesenhofer, Niklas Kampleitner, Madhumitha Narasimhan, Thomas Schmitt, and Sylvia Cremer. “Pathogen Evasion of Social Immunity.” <i>Nature Ecology and Evolution</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41559-023-01981-6\">https://doi.org/10.1038/s41559-023-01981-6</a>.","mla":"Stock, Miriam, et al. “Pathogen Evasion of Social Immunity.” <i>Nature Ecology and Evolution</i>, vol. 7, Springer Nature, 2023, pp. 450–60, doi:<a href=\"https://doi.org/10.1038/s41559-023-01981-6\">10.1038/s41559-023-01981-6</a>.","ama":"Stock M, Milutinovic B, Hönigsberger M, et al. Pathogen evasion of social immunity. <i>Nature Ecology and Evolution</i>. 2023;7:450-460. doi:<a href=\"https://doi.org/10.1038/s41559-023-01981-6\">10.1038/s41559-023-01981-6</a>"},"publisher":"Springer Nature","related_material":{"link":[{"relation":"press_release","description":"News on ISTA website","url":"https://ista.ac.at/en/news/how-sneaky-germs-hide-from-ants/"}]},"date_updated":"2025-04-14T07:47:53Z","author":[{"full_name":"Stock, Miriam","first_name":"Miriam","id":"42462816-F248-11E8-B48F-1D18A9856A87","last_name":"Stock"},{"id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","last_name":"Milutinovic","orcid":"0000-0002-8214-4758","first_name":"Barbara","full_name":"Milutinovic, Barbara"},{"first_name":"Michaela","full_name":"Hönigsberger, Michaela","last_name":"Hönigsberger","id":"953894f3-25bd-11ec-8556-f70a9d38ef60"},{"first_name":"Anna V","full_name":"Grasse, Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","last_name":"Grasse"},{"first_name":"Florian","full_name":"Wiesenhofer, Florian","last_name":"Wiesenhofer","id":"39523C54-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kampleitner, Niklas","first_name":"Niklas","id":"2AC57FAC-F248-11E8-B48F-1D18A9856A87","last_name":"Kampleitner"},{"orcid":"0000-0002-8600-0671","id":"44BF24D0-F248-11E8-B48F-1D18A9856A87","last_name":"Narasimhan","full_name":"Narasimhan, Madhumitha","first_name":"Madhumitha"},{"first_name":"Thomas","full_name":"Schmitt, Thomas","last_name":"Schmitt"},{"first_name":"Sylvia","full_name":"Cremer, Sylvia","last_name":"Cremer","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"project":[{"name":"Epidemics in ant societies on a chip","grant_number":"771402","_id":"2649B4DE-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"grant_number":"CR-118/3-1","name":"Host-Parasite Coevolution","_id":"25DAF0B2-B435-11E9-9278-68D0E5697425"}],"corr_author":"1","abstract":[{"lang":"eng","text":"Treating sick group members is a hallmark of collective disease defence in vertebrates and invertebrates alike. Despite substantial effects on pathogen fitness and epidemiology, it is still largely unknown how pathogens react to the selection pressure imposed by care intervention. Using social insects and pathogenic fungi, we here performed a serial passage experiment in the presence or absence of colony members, which provide social immunity by grooming off infectious spores from exposed individuals. We found specific effects on pathogen diversity, virulence and transmission. Under selection of social immunity, pathogens invested into higher spore production, but spores were less virulent. Notably, they also elicited a lower grooming response in colony members, compared with spores from the individual host selection lines. Chemical spore analysis suggested that the spores from social selection lines escaped the caregivers’ detection by containing lower levels of ergosterol, a key fungal membrane component. Experimental application of chemically pure ergosterol indeed induced sanitary grooming, supporting its role as a microbe-associated cue triggering host social immunity against fungal pathogens. By reducing this detection cue, pathogens were able to evade the otherwise very effective collective disease defences of their social hosts."}],"page":"450-460","ddc":["570"],"publication_status":"published","oa_version":"Published Version","isi":1,"department":[{"_id":"SyCr"},{"_id":"LifeSc"},{"_id":"JiFr"}],"doi":"10.1038/s41559-023-01981-6","day":"01","has_accepted_license":"1"},{"page":"973-985","corr_author":"1","abstract":[{"lang":"eng","text":"Geometry is crucial in our efforts to comprehend the structures and dynamics of biomolecules. For example, volume, surface area, and integrated mean and Gaussian curvature of the union of balls representing a molecule are used to quantify its interactions with the water surrounding it in the morphometric implicit solvent models. The Alpha Shape theory provides an accurate and reliable method for computing these geometric measures. In this paper, we derive homogeneous formulas for the expressions of these measures and their derivatives with respect to the atomic coordinates, and we provide algorithms that implement them into a new software package, AlphaMol. The only variables in these formulas are the interatomic distances, making them insensitive to translations and rotations. AlphaMol includes a sequential algorithm and a parallel algorithm. In the parallel version, we partition the atoms of the molecule of interest into 3D rectangular blocks, using a kd-tree algorithm. We then apply the sequential algorithm of AlphaMol to each block, augmented by a buffer zone to account for atoms whose ball representations may partially cover the block. The current parallel version of AlphaMol leads to a 20-fold speed-up compared to an independent serial implementation when using 32 processors. For instance, it takes 31 s to compute the geometric measures and derivatives of each atom in a viral capsid with more than 26 million atoms on 32 Intel processors running at 2.7 GHz. The presence of the buffer zones, however, leads to redundant computations, which ultimately limit the impact of using multiple processors. AlphaMol is available as an OpenSource software."}],"publication_status":"published","ddc":["510","540"],"oa_version":"Published Version","department":[{"_id":"HeEd"}],"isi":1,"doi":"10.1021/acs.jcim.2c01346","day":"13","has_accepted_license":"1","oa":1,"acknowledgement":"P.K. acknowledges support from the University of California Multicampus Research Programs and Initiatives (Grant No. M21PR3267) and from the NSF (Grant No.1760485). H.E. acknowledges support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program, Grant No. 788183, from the Wittgenstein Prize, Austrian Science Fund (FWF), Grant No. Z 342-N31, and from the DFG Collaborative Research Center TRR 109, ‘Discretization in Geometry and Dynamics’, Austrian Science Fund (FWF), Grant No. I 02979-N35.\r\nOpen Access is funded by the Austrian Science Fund (FWF).","publication_identifier":{"issn":["1549-9596"],"eissn":["1549-960X"]},"status":"public","publication":"Journal of Chemical Information and Modeling","scopus_import":"1","pmid":1,"ec_funded":1,"quality_controlled":"1","citation":{"mla":"Koehl, Patrice, et al. “Computing the Volume, Surface Area, Mean, and Gaussian Curvatures of Molecules and Their Derivatives.” <i>Journal of Chemical Information and Modeling</i>, vol. 63, no. 3, American Chemical Society, 2023, pp. 973–85, doi:<a href=\"https://doi.org/10.1021/acs.jcim.2c01346\">10.1021/acs.jcim.2c01346</a>.","ama":"Koehl P, Akopyan A, Edelsbrunner H. Computing the volume, surface area, mean, and Gaussian curvatures of molecules and their derivatives. <i>Journal of Chemical Information and Modeling</i>. 2023;63(3):973-985. doi:<a href=\"https://doi.org/10.1021/acs.jcim.2c01346\">10.1021/acs.jcim.2c01346</a>","short":"P. Koehl, A. Akopyan, H. Edelsbrunner, Journal of Chemical Information and Modeling 63 (2023) 973–985.","apa":"Koehl, P., Akopyan, A., &#38; Edelsbrunner, H. (2023). Computing the volume, surface area, mean, and Gaussian curvatures of molecules and their derivatives. <i>Journal of Chemical Information and Modeling</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.jcim.2c01346\">https://doi.org/10.1021/acs.jcim.2c01346</a>","ista":"Koehl P, Akopyan A, Edelsbrunner H. 2023. Computing the volume, surface area, mean, and Gaussian curvatures of molecules and their derivatives. Journal of Chemical Information and Modeling. 63(3), 973–985.","ieee":"P. Koehl, A. Akopyan, and H. Edelsbrunner, “Computing the volume, surface area, mean, and Gaussian curvatures of molecules and their derivatives,” <i>Journal of Chemical Information and Modeling</i>, vol. 63, no. 3. American Chemical Society, pp. 973–985, 2023.","chicago":"Koehl, Patrice, Arseniy Akopyan, and Herbert Edelsbrunner. “Computing the Volume, Surface Area, Mean, and Gaussian Curvatures of Molecules and Their Derivatives.” <i>Journal of Chemical Information and Modeling</i>. American Chemical Society, 2023. <a href=\"https://doi.org/10.1021/acs.jcim.2c01346\">https://doi.org/10.1021/acs.jcim.2c01346</a>."},"publisher":"American Chemical Society","project":[{"call_identifier":"H2020","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","name":"Alpha Shape Theory Extended","grant_number":"788183"},{"call_identifier":"FWF","_id":"268116B8-B435-11E9-9278-68D0E5697425","grant_number":"Z00342","name":"Mathematics, Computer Science"},{"name":"Persistence and stability of geometric complexes","grant_number":"I02979-N35","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"date_updated":"2025-04-15T07:16:52Z","author":[{"last_name":"Koehl","full_name":"Koehl, Patrice","first_name":"Patrice"},{"full_name":"Akopyan, Arseniy","first_name":"Arseniy","last_name":"Akopyan","id":"430D2C90-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2548-617X"},{"first_name":"Herbert","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833"}],"article_type":"original","file":[{"file_name":"2023_JCIM_Koehl.pdf","relation":"main_file","date_updated":"2023-08-16T12:21:13Z","success":1,"file_id":"14070","checksum":"7d20562269edff1e31b9d6019d4983b0","content_type":"application/pdf","file_size":8069223,"creator":"dernst","date_created":"2023-08-16T12:21:13Z","access_level":"open_access"}],"month":"02","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-02-12T23:00:59Z","type":"journal_article","language":[{"iso":"eng"}],"intvolume":"        63","volume":63,"issue":"3","date_published":"2023-02-13T00:00:00Z","_id":"12544","title":"Computing the volume, surface area, mean, and Gaussian curvatures of molecules and their derivatives","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2023","external_id":{"pmid":["36638318"],"isi":["000920370700001"]},"file_date_updated":"2023-08-16T12:21:13Z"}]