[{"month":"10","publisher":"Public Library of Science","article_processing_charge":"No","year":"2024","abstract":[{"text":"A tight regulation of morphogen production is key for morphogen gradient formation and thereby for reproducible and organised organ development. Although many genetic interactions involved in the establishment of morphogen production domains are known, the biophysical mechanisms of morphogen source formation are poorly understood. Here we addressed this by focusing on the morphogen Sonic hedgehog (Shh) in the vertebrate neural tube. Shh is produced by the adjacently located notochord and by the floor plate of the neural tube. Using a data-constrained computational screen, we identified different possible mechanisms by which floor plate formation can occur, only one of which is consistent with experimental data. In this mechanism, the floor plate is established rapidly in response to Shh from the notochord and the dynamics of regulatory interactions within the neural tube. In this process, uniform activators and Shh-dependent repressors are key for establishing the floor plate size. Subsequently, the floor plate becomes insensitive to Shh and increases in size due to tissue growth, leading to scaling of the floor plate with neural tube size. In turn, this results in scaling of the Shh amplitude with tissue growth. Thus, this mechanism ensures a separation of time scales in floor plate formation, so that the floor plate domain becomes growth-dependent after an initial rapid establishment phase. Our study raises the possibility that the time scale separation between specification and growth might be a common strategy for scaling the morphogen gradient amplitude in growing organs. The model that we developed provides a new opportunity for quantitative studies of morphogen source formation in growing tissues.","lang":"eng"}],"project":[{"name":"Mechanisms of tissue size regulation in spinal cord development","_id":"bd7e737f-d553-11ed-ba76-d69ffb5ee3aa","grant_number":"101044579"},{"name":"Stem Cell Modulation in Neural Development and Regeneration/ P02-Morphogen control of growth and pattern in the spinal cord","_id":"059DF620-7A3F-11EA-A408-12923DDC885E","grant_number":"F7802"}],"date_published":"2024-10-14T00:00:00Z","status":"public","dataavailabilitystatement":"Custom software in C++ used to run the computational screen is available as S1 Simulation code. Custom script in Python used to analyze Shh profiles is available as S1 Script code. All data are in the manuscript and/or supporting information files","publication_status":"published","type":"journal_article","file_date_updated":"2024-10-29T11:59:09Z","das_tickbox":"1","day":"14","has_accepted_license":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","supplementarymaterial":"yes","publication_identifier":{"issn":["1553-734X"],"eissn":["1553-7358"]},"author":[{"first_name":"Richard D.J.G.","last_name":"Ho","full_name":"Ho, Richard D.J.G."},{"last_name":"Kishi","full_name":"Kishi, Kasumi","id":"3065DFC4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6060-4795","first_name":"Kasumi"},{"first_name":"Maciej","last_name":"Majka","full_name":"Majka, Maciej"},{"last_name":"Kicheva","full_name":"Kicheva, Anna","first_name":"Anna","orcid":"0000-0003-4509-4998","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Zagórski","full_name":"Zagórski, Marcin P","id":"343DA0DC-F248-11E8-B48F-1D18A9856A87","first_name":"Marcin P","orcid":"0000-0001-7896-7762"}],"department":[{"_id":"AnKi"}],"researchdata_availability":"yes","related_material":{"record":[{"status":"public","id":"20393","relation":"dissertation_contains"}]},"article_type":"original","fulldoi":"https://doi.org/10.1371/journal.pcbi.1012508","corr_author":"1","OA_place":"publisher","quality_controlled":"1","date_created":"2024-10-27T23:01:45Z","acknowledgement":"We thank Martina Greunz-Schindler for technical support, and Thomas Minchington and James Briscoe for comments on the manuscript.\r\nRDJGH, MM and MZ were supported by a grant from the Priority Research Area DigiWorld\r\nunder the Strategic Programme Excellence Initiative at Jagiellonian University. The research\r\nwas supported by the Polish National Agency for Academic Exchange, PN/PPO/2018/1/00011/U/00001 which paid the salary of MM and MZ up to Feb 2023. The research received support from National Science Center, Poland, 2021/42/E/NZ2/00188 which paid salary of MZ. Work in the AK labis supported by ISTA to KK and AK, the European\r\nResearch Council under Horizon Europe: grant 101044579 to AK, and Austrian Science Fund\r\n(FWF): Grant DOI 10.55776/F78 to AK. The salaries of AK and KK were paid by ISTA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","article_number":"e1012508","external_id":{"isi":["001331700300003"],"pmid":["39401260"]},"pmid":1,"isi":1,"intvolume":" 20","ddc":["570"],"doi":"10.1371/journal.pcbi.1012508","language":[{"iso":"eng"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2026-10-16T08:31:15Z","scopus_import":"1","APC_amount":"3197,23 EUR","license":"https://creativecommons.org/licenses/by/4.0/","DOAJ_listed":"1","oa":1,"title":"Dynamics of morphogen source formation in a growing tissue","OA_type":"gold","file":[{"access_level":"open_access","date_created":"2024-10-29T11:59:09Z","content_type":"application/pdf","relation":"main_file","file_name":"2024_PloSComBio_Ho.pdf","file_size":3732443,"file_id":"18487","date_updated":"2024-10-29T11:59:09Z","success":1,"checksum":"42fa714459943cb3961b40fab8fd82c8","creator":"dernst"}],"citation":{"apa":"Ho, R. D. J. G., Kishi, K., Majka, M., Kicheva, A., & Zagórski, M. P. (2024). Dynamics of morphogen source formation in a growing tissue. PLoS Computational Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1012508","ama":"Ho RDJG, Kishi K, Majka M, Kicheva A, Zagórski MP. Dynamics of morphogen source formation in a growing tissue. PLoS Computational Biology. 2024;20. doi:10.1371/journal.pcbi.1012508","chicago":"Ho, Richard D.J.G., Kasumi Kishi, Maciej Majka, Anna Kicheva, and Marcin P Zagórski. “Dynamics of Morphogen Source Formation in a Growing Tissue.” PLoS Computational Biology. Public Library of Science, 2024. https://doi.org/10.1371/journal.pcbi.1012508.","mla":"Ho, Richard D. J. G., et al. “Dynamics of Morphogen Source Formation in a Growing Tissue.” PLoS Computational Biology, vol. 20, e1012508, Public Library of Science, 2024, doi:10.1371/journal.pcbi.1012508.","ieee":"R. D. J. G. Ho, K. Kishi, M. Majka, A. Kicheva, and M. P. Zagórski, “Dynamics of morphogen source formation in a growing tissue,” PLoS Computational Biology, vol. 20. Public Library of Science, 2024.","short":"R.D.J.G. Ho, K. Kishi, M. Majka, A. Kicheva, M.P. Zagórski, PLoS Computational Biology 20 (2024).","ista":"Ho RDJG, Kishi K, Majka M, Kicheva A, Zagórski MP. 2024. Dynamics of morphogen source formation in a growing tissue. PLoS Computational Biology. 20, e1012508."},"publication":"PLoS Computational Biology","volume":20,"_id":"18481"},{"status":"public","date_published":"2024-12-01T00:00:00Z","dataavailabilitystatement":"There is no data associated to this work.","publication_status":"published","type":"journal_article","file_date_updated":"2024-11-18T08:15:07Z","month":"12","publisher":"Springer Nature","article_processing_charge":"Yes (via OA deal)","year":"2024","abstract":[{"text":"We prove the Eigenstate Thermalization Hypothesis for general Wigner-type matrices in the bulk of the self-consistent spectrum, with optimal control on the fluctuations for obs ervables of arbitrary rank. As the main technical ingredient, we prove rank-uniform optimal local laws for one and two resolvents of a Wigner-type matrix with regular observables. Our results hold under very general conditions on the variance profile, even allowing many vanishing entries, demonstrating that Eigenstate Thermalization occurs robustly across a diverse class of random matrix ensembles, for which the underlying quantum system has a non-trivial spatial structure.","lang":"eng"}],"author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös"},{"last_name":"Riabov","full_name":"Riabov, Volodymyr","id":"1949f904-edfb-11eb-afb5-e2dfddabb93b","first_name":"Volodymyr"}],"department":[{"_id":"LaEr"}],"researchdata_availability":"not applicable","related_material":{"record":[{"id":"20575","relation":"dissertation_contains","status":"public"}]},"article_type":"original","fulldoi":"https://doi.org/10.1007/s00220-024-05143-y","corr_author":"1","OA_place":"publisher","das_tickbox":"1","has_accepted_license":"1","day":"01","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","supplementarymaterial":"yes","publication_identifier":{"issn":["0010-3616"],"eissn":["1432-0916"]},"isi":1,"intvolume":" 405","ddc":["510"],"doi":"10.1007/s00220-024-05143-y","language":[{"iso":"eng"}],"quality_controlled":"1","date_created":"2024-11-17T23:01:46Z","acknowledgement":"Open access funding provided by Institute of Science and Technology (IST Austria).","article_number":"282","issue":"12","external_id":{"pmid":["39526190"],"isi":["001348943900004"],"arxiv":["2403.10359"]},"pmid":1,"file":[{"checksum":"c9ae0ea195bd39b8b3a630d492fb00dc","creator":"dernst","success":1,"file_id":"18562","file_size":1426046,"relation":"main_file","file_name":"2024_CommMathPhysics_Erdoes.pdf","content_type":"application/pdf","date_updated":"2024-11-18T08:15:07Z","date_created":"2024-11-18T08:15:07Z","access_level":"open_access"}],"citation":{"ieee":"L. Erdös and V. Riabov, “Eigenstate Thermalization Hypothesis for Wigner-type matrices,” Communications in Mathematical Physics, vol. 405, no. 12. Springer Nature, 2024.","mla":"Erdös, László, and Volodymyr Riabov. “Eigenstate Thermalization Hypothesis for Wigner-Type Matrices.” Communications in Mathematical Physics, vol. 405, no. 12, 282, Springer Nature, 2024, doi:10.1007/s00220-024-05143-y.","ista":"Erdös L, Riabov V. 2024. Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. 405(12), 282.","short":"L. Erdös, V. Riabov, Communications in Mathematical Physics 405 (2024).","apa":"Erdös, L., & Riabov, V. (2024). Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s00220-024-05143-y","chicago":"Erdös, László, and Volodymyr Riabov. “Eigenstate Thermalization Hypothesis for Wigner-Type Matrices.” Communications in Mathematical Physics. Springer Nature, 2024. https://doi.org/10.1007/s00220-024-05143-y.","ama":"Erdös L, Riabov V. Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. 2024;405(12). doi:10.1007/s00220-024-05143-y"},"arxiv":1,"publication":"Communications in Mathematical Physics","_id":"18554","volume":405,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2026-10-16T08:34:30Z","scopus_import":"1","title":"Eigenstate Thermalization Hypothesis for Wigner-type matrices","oa":1,"OA_type":"hybrid"},{"dataavailabilitystatement":"All data generated or analyzed during this study are included in this published article.","status":"public","date_published":"2024-03-01T00:00:00Z","publication_status":"published","type":"journal_article","file_date_updated":"2024-07-22T09:41:21Z","month":"03","article_processing_charge":"Yes (via OA deal)","year":"2024","publisher":"Springer Nature","abstract":[{"text":"We consider the spectrum of random Laplacian matrices of the form Ln=An−Dn where An\r\n is a real symmetric random matrix and Dn is a diagonal matrix whose entries are equal to the corresponding row sums of An. If An is a Wigner matrix with entries in the domain of attraction of a Gaussian distribution, the empirical spectral measure of Ln is known to converge to the free convolution of a semicircle distribution and a standard real Gaussian distribution. We consider real symmetric random matrices An with independent entries (up to symmetry) whose row sums converge to a purely non-Gaussian infinitely divisible distribution, which fall into the class of Lévy–Khintchine random matrices first introduced by Jung [Trans Am Math Soc, 370, (2018)]. Our main result shows that the empirical spectral measure of Ln converges almost surely to a deterministic limit. A key step in the proof is to use the purely non-Gaussian nature of the row sums to build a random operator to which Ln converges in an appropriate sense. This operator leads to a recursive distributional equation uniquely describing the Stieltjes transform of the limiting empirical spectral measure.","lang":"eng"}],"researchdata_availability":"yes (supplementary data)","author":[{"first_name":"Andrew J","id":"582b06a9-1f1c-11ee-b076-82ffce00dde4","last_name":"Campbell","full_name":"Campbell, Andrew J"},{"first_name":"Sean","last_name":"O’Rourke","full_name":"O’Rourke, Sean"}],"department":[{"_id":"LaEr"}],"article_type":"original","corr_author":"1","fulldoi":"https://doi.org/10.1007/s10959-023-01275-4","das_tickbox":"1","has_accepted_license":"1","day":"01","supplementarymaterial":"yes","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_identifier":{"eissn":["1572-9230"],"issn":["0894-9840"]},"intvolume":" 37","isi":1,"ddc":["510"],"doi":"10.1007/s10959-023-01275-4","language":[{"iso":"eng"}],"quality_controlled":"1","date_created":"2023-08-06T22:01:13Z","acknowledgement":"The first author thanks Yizhe Zhu for pointing out reference [30]. We thank David Renfrew for comments on an earlier draft. We thank the anonymous referee for a careful reading and helpful comments.\r\nOpen access funding provided by Institute of Science and Technology (IST Austria).","external_id":{"arxiv":["2210.07927"],"isi":["001038341000001"]},"file":[{"creator":"dernst","checksum":"f7793d313104c70422140c5e6494c779","success":1,"date_updated":"2024-07-22T09:41:21Z","file_id":"17300","file_size":555070,"content_type":"application/pdf","file_name":"2024_JourTheorProbab_Campbell.pdf","relation":"main_file","date_created":"2024-07-22T09:41:21Z","access_level":"open_access"}],"citation":{"apa":"Campbell, A. J., & O’Rourke, S. (2024). Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. Springer Nature. https://doi.org/10.1007/s10959-023-01275-4","chicago":"Campbell, Andrew J, and Sean O’Rourke. “Spectrum of Lévy–Khintchine Random Laplacian Matrices.” Journal of Theoretical Probability. Springer Nature, 2024. https://doi.org/10.1007/s10959-023-01275-4.","ama":"Campbell AJ, O’Rourke S. Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. 2024;37:933-973. doi:10.1007/s10959-023-01275-4","mla":"Campbell, Andrew J., and Sean O’Rourke. “Spectrum of Lévy–Khintchine Random Laplacian Matrices.” Journal of Theoretical Probability, vol. 37, Springer Nature, 2024, pp. 933–73, doi:10.1007/s10959-023-01275-4.","ieee":"A. J. Campbell and S. O’Rourke, “Spectrum of Lévy–Khintchine random laplacian matrices,” Journal of Theoretical Probability, vol. 37. Springer Nature, pp. 933–973, 2024.","ista":"Campbell AJ, O’Rourke S. 2024. Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. 37, 933–973.","short":"A.J. Campbell, S. O’Rourke, Journal of Theoretical Probability 37 (2024) 933–973."},"arxiv":1,"publication":"Journal of Theoretical Probability","page":"933-973","_id":"13975","volume":37,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","scopus_import":"1","date_updated":"2026-10-16T08:30:34Z","oa":1,"title":"Spectrum of Lévy–Khintchine random laplacian matrices"},{"publication_status":"published","status":"public","date_published":"2024-07-01T00:00:00Z","file_date_updated":"2024-07-22T06:40:19Z","type":"journal_article","month":"07","abstract":[{"text":"We extend the free convolution of Brown measures of R-diagonal elements introduced by Kösters and Tikhomirov [ 28] to fractional powers. We then show how this fractional free convolution arises naturally when studying the roots of random polynomials with independent coefficients under repeated differentiation. When the proportion of derivatives to the degree approaches one, we establish central limit theorem-type behavior and discuss stable distributions.","lang":"eng"}],"year":"2024","article_processing_charge":"Yes (via OA deal)","publisher":"Oxford University Press","article_type":"original","researchdata_availability":"no","department":[{"_id":"LaEr"}],"author":[{"full_name":"Campbell, Andrew J","last_name":"Campbell","first_name":"Andrew J","id":"582b06a9-1f1c-11ee-b076-82ffce00dde4"},{"first_name":"Sean","last_name":"O'Rourke","full_name":"O'Rourke, Sean"},{"last_name":"Renfrew","full_name":"Renfrew, David T","first_name":"David T","orcid":"0000-0003-3493-121X","id":"4845BF6A-F248-11E8-B48F-1D18A9856A87"}],"corr_author":"1","fulldoi":"https://doi.org/10.1093/imrn/rnae062","day":"01","has_accepted_license":"1","das_tickbox":"0","publication_identifier":{"eissn":["1687-0247"],"issn":["1073-7928"]},"supplementarymaterial":"yes","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","ddc":["510"],"intvolume":" 2024","isi":1,"language":[{"iso":"eng"}],"doi":"10.1093/imrn/rnae062","acknowledgement":"This work was supported by the National Science Foundation [Grant No. DMS-2143142 to S.O.]; and the European Research Council [Grant No. 101020331].The third author acknowledges the support of the University of Colorado Boulder, where a portion of this work was completed. The authors thank Martin Auer, Vadim Gorin, Brian Hall, and Noah Williams for comments, corrections, and references. The authors also wish to thank the anonymous referees for useful feedback and corrections.","date_created":"2024-07-21T22:01:01Z","quality_controlled":"1","external_id":{"isi":["001198019500001"]},"issue":"13","publication":"International Mathematics Research Notices","file":[{"file_size":1233508,"file_id":"17288","content_type":"application/pdf","relation":"main_file","file_name":"2024_IMRN_Campbell.pdf","date_updated":"2024-07-22T06:40:19Z","date_created":"2024-07-22T06:40:19Z","access_level":"open_access","checksum":"f36a7dbf53f23d5833db711052e69b49","creator":"dernst","success":1}],"citation":{"short":"A.J. Campbell, S. O’Rourke, D.T. Renfrew, International Mathematics Research Notices 2024 (2024) 10189–10218.","ista":"Campbell AJ, O’Rourke S, Renfrew DT. 2024. The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation. International Mathematics Research Notices. 2024(13), 10189–10218.","mla":"Campbell, Andrew J., et al. “The Fractional Free Convolution of R-Diagonal Elements and Random Polynomials under Repeated Differentiation.” International Mathematics Research Notices, vol. 2024, no. 13, Oxford University Press, 2024, pp. 10189–218, doi:10.1093/imrn/rnae062.","ieee":"A. J. Campbell, S. O’Rourke, and D. T. Renfrew, “The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation,” International Mathematics Research Notices, vol. 2024, no. 13. Oxford University Press, pp. 10189–10218, 2024.","ama":"Campbell AJ, O’Rourke S, Renfrew DT. The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation. International Mathematics Research Notices. 2024;2024(13):10189-10218. doi:10.1093/imrn/rnae062","chicago":"Campbell, Andrew J, Sean O’Rourke, and David T Renfrew. “The Fractional Free Convolution of R-Diagonal Elements and Random Polynomials under Repeated Differentiation.” International Mathematics Research Notices. Oxford University Press, 2024. https://doi.org/10.1093/imrn/rnae062.","apa":"Campbell, A. J., O’Rourke, S., & Renfrew, D. T. (2024). The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation. International Mathematics Research Notices. Oxford University Press. https://doi.org/10.1093/imrn/rnae062"},"volume":2024,"_id":"17281","page":"10189-10218","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"title":"The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation","scopus_import":"1","date_updated":"2026-10-16T08:32:45Z"},{"type":"journal_article","publication_status":"published","status":"public","date_published":"2024-04-01T00:00:00Z","abstract":[{"text":"We prove that the mesoscopic linear statistics ∑if(na(σi−z0)) of the eigenvalues {σi}i of large n×n non-Hermitian random matrices with complex centred i.i.d. entries are asymptotically Gaussian for any H20-functions f around any point z0 in the bulk of the spectrum on any mesoscopic scale 0Probability Theory and Related Fields. Springer Nature. https://doi.org/10.1007/s00440-023-01229-1","ama":"Cipolloni G, Erdös L, Schröder DJ. Mesoscopic central limit theorem for non-Hermitian random matrices. Probability Theory and Related Fields. 2024;188:1131-1182. doi:10.1007/s00440-023-01229-1","chicago":"Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Mesoscopic Central Limit Theorem for Non-Hermitian Random Matrices.” Probability Theory and Related Fields. Springer Nature, 2024. https://doi.org/10.1007/s00440-023-01229-1.","ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “Mesoscopic central limit theorem for non-Hermitian random matrices,” Probability Theory and Related Fields, vol. 188. Springer Nature, pp. 1131–1182, 2024.","mla":"Cipolloni, Giorgio, et al. “Mesoscopic Central Limit Theorem for Non-Hermitian Random Matrices.” Probability Theory and Related Fields, vol. 188, Springer Nature, 2024, pp. 1131–82, doi:10.1007/s00440-023-01229-1.","short":"G. Cipolloni, L. Erdös, D.J. Schröder, Probability Theory and Related Fields 188 (2024) 1131–1182.","ista":"Cipolloni G, Erdös L, Schröder DJ. 2024. Mesoscopic central limit theorem for non-Hermitian random matrices. Probability Theory and Related Fields. 188, 1131–1182."},"arxiv":1,"oa":1,"title":"Mesoscopic central limit theorem for non-Hermitian random matrices","date_updated":"2026-10-16T08:31:03Z","scopus_import":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2210.12060"}]},{"publication_status":"published","status":"public","date_published":"2024-06-01T00:00:00Z","dataavailabilitystatement":"Data sharing is not applicable to this article as no new data were created or analyzed in this study.\r\n\r\n","type":"journal_article","month":"06","abstract":[{"text":"We consider the spectral radius of a large random matrix X with independent, identically distributed entries. We show that its typical size is given by a precise three-term asymptotics with an optimal error term beyond the radius of the celebrated circular law. The coefficients in this asymptotics are universal but they differ from a similar asymptotics recently proved for the rightmost eigenvalue of X in Cipolloni et al., Ann. Probab. 51(6), 2192–2242 (2023). To access the more complicated spectral radius, we need to establish a new decorrelation mechanism for the low-lying singular values of X − z for different complex shift parameters z using the Dyson Brownian Motion.","lang":"eng"}],"project":[{"call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta","_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331"}],"publisher":"AIP Publishing","year":"2024","article_processing_charge":"No","article_type":"original","department":[{"_id":"LaEr"}],"author":[{"orcid":"0000-0002-4901-7992","first_name":"Giorgio","id":"42198EFA-F248-11E8-B48F-1D18A9856A87","full_name":"Cipolloni, Giorgio","last_name":"Cipolloni"},{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","first_name":"László","full_name":"Erdös, László","last_name":"Erdös"},{"first_name":"Yuanyuan","orcid":"0000-0003-1559-1205","id":"7902bdb1-a2a4-11eb-a164-c9216f71aea3","full_name":"Xu, Yuanyuan","last_name":"Xu"}],"researchdata_availability":"not applicable","ec_funded":1,"fulldoi":"https://doi.org/10.1063/5.0209705","corr_author":"1","day":"01","das_tickbox":"1","publication_identifier":{"issn":["0022-2488"]},"oa_version":"Preprint","supplementarymaterial":"yes","isi":1,"intvolume":" 65","language":[{"iso":"eng"}],"doi":"10.1063/5.0209705","date_created":"2024-08-04T22:01:22Z","acknowledgement":"L.E. and Y.X. were supported by the ERC Advanced Grant “RMTBeyond” Grant No. 101020331.","quality_controlled":"1","external_id":{"arxiv":["2210.15643"],"isi":["001252240700002"]},"article_number":"063302","issue":"6","publication":"Journal of Mathematical Physics","arxiv":1,"citation":{"short":"G. Cipolloni, L. Erdös, Y. Xu, Journal of Mathematical Physics 65 (2024).","ista":"Cipolloni G, Erdös L, Xu Y. 2024. Precise asymptotics for the spectral radius of a large random matrix. Journal of Mathematical Physics. 65(6), 063302.","ieee":"G. Cipolloni, L. Erdös, and Y. Xu, “Precise asymptotics for the spectral radius of a large random matrix,” Journal of Mathematical Physics, vol. 65, no. 6. AIP Publishing, 2024.","mla":"Cipolloni, Giorgio, et al. “Precise Asymptotics for the Spectral Radius of a Large Random Matrix.” Journal of Mathematical Physics, vol. 65, no. 6, 063302, AIP Publishing, 2024, doi:10.1063/5.0209705.","ama":"Cipolloni G, Erdös L, Xu Y. Precise asymptotics for the spectral radius of a large random matrix. Journal of Mathematical Physics. 2024;65(6). doi:10.1063/5.0209705","chicago":"Cipolloni, Giorgio, László Erdös, and Yuanyuan Xu. “Precise Asymptotics for the Spectral Radius of a Large Random Matrix.” Journal of Mathematical Physics. AIP Publishing, 2024. https://doi.org/10.1063/5.0209705.","apa":"Cipolloni, G., Erdös, L., & Xu, Y. (2024). Precise asymptotics for the spectral radius of a large random matrix. Journal of Mathematical Physics. AIP Publishing. https://doi.org/10.1063/5.0209705"},"_id":"17375","volume":65,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2210.15643","open_access":"1"}],"title":"Precise asymptotics for the spectral radius of a large random matrix","oa":1,"date_updated":"2026-10-16T08:33:32Z","scopus_import":"1"},{"year":"2024","article_processing_charge":"No","publisher":"Institute of Mathematical Statistics","project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta","grant_number":"101020331"}],"abstract":[{"text":"We consider quadratic forms of deterministic matrices A evaluated at the random eigenvectors of a large N×N GOE or GUE matrix, or equivalently evaluated at the columns of a Haar-orthogonal or Haar-unitary random matrix. We prove that, as long as the deterministic matrix has rank much smaller than √N, the distributions of the extrema of these quadratic forms are asymptotically the same as if the eigenvectors were independent Gaussians. This reduces the problem to Gaussian computations, which we carry out in several cases to illustrate our result, finding Gumbel or Weibull limiting distributions depending on the signature of A. Our result also naturally applies to the eigenvectors of any invariant ensemble.","lang":"eng"}],"month":"02","type":"journal_article","status":"public","date_published":"2024-02-01T00:00:00Z","publication_status":"published","supplementarymaterial":"yes","oa_version":"Preprint","publication_identifier":{"issn":["1050-5164"]},"das_tickbox":"0","day":"01","corr_author":"1","fulldoi":"https://doi.org/10.1214/23-AAP2000","ec_funded":1,"researchdata_availability":"no","department":[{"_id":"LaEr"}],"author":[{"last_name":"Erdös","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","first_name":"László"},{"last_name":"McKenna","full_name":"McKenna, Benjamin","orcid":"0000-0003-2625-495X","first_name":"Benjamin","id":"b0cc634c-d549-11ee-96c8-87338c7ad808"}],"article_type":"original","issue":"1B","external_id":{"isi":["001163006100021"],"arxiv":["2208.12206"]},"quality_controlled":"1","acknowledgement":"The first author was supported by the ERC Advanced Grant “RMTBeyond” No. 101020331. The second author was supported by Fulbright Austria and the Austrian Marshall Plan Foundation.","date_created":"2024-02-25T23:00:56Z","doi":"10.1214/23-AAP2000","language":[{"iso":"eng"}],"intvolume":" 34","isi":1,"scopus_import":"1","date_updated":"2026-10-16T08:33:55Z","oa":1,"title":"Extremal statistics of quadratic forms of GOE/GUE eigenvectors","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2208.12206","open_access":"1"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"1623-1662","volume":34,"_id":"15025","citation":{"mla":"Erdös, László, and Benjamin McKenna. “Extremal Statistics of Quadratic Forms of GOE/GUE Eigenvectors.” Annals of Applied Probability, vol. 34, no. 1B, Institute of Mathematical Statistics, 2024, pp. 1623–62, doi:10.1214/23-AAP2000.","ieee":"L. Erdös and B. McKenna, “Extremal statistics of quadratic forms of GOE/GUE eigenvectors,” Annals of Applied Probability, vol. 34, no. 1B. Institute of Mathematical Statistics, pp. 1623–1662, 2024.","short":"L. Erdös, B. McKenna, Annals of Applied Probability 34 (2024) 1623–1662.","ista":"Erdös L, McKenna B. 2024. Extremal statistics of quadratic forms of GOE/GUE eigenvectors. Annals of Applied Probability. 34(1B), 1623–1662.","apa":"Erdös, L., & McKenna, B. (2024). Extremal statistics of quadratic forms of GOE/GUE eigenvectors. Annals of Applied Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/23-AAP2000","ama":"Erdös L, McKenna B. Extremal statistics of quadratic forms of GOE/GUE eigenvectors. Annals of Applied Probability. 2024;34(1B):1623-1662. doi:10.1214/23-AAP2000","chicago":"Erdös, László, and Benjamin McKenna. “Extremal Statistics of Quadratic Forms of GOE/GUE Eigenvectors.” Annals of Applied Probability. Institute of Mathematical Statistics, 2024. https://doi.org/10.1214/23-AAP2000."},"arxiv":1,"publication":"Annals of Applied Probability"},{"publication_identifier":{"issn":["2663-337X"]},"supplementarymaterial":"no","tmp":{"image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"oa_version":"Published Version","has_accepted_license":"1","day":"26","das_tickbox":"0","OA_place":"publisher","ec_funded":1,"corr_author":"1","fulldoi":"https://doi.org/10.15479/at:ista:17164","alternative_title":["ISTA Thesis"],"researchdata_availability":"no","related_material":{"record":[{"id":"17173","relation":"part_of_dissertation","status":"public"},{"id":"11135","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","id":"17174","status":"public"},{"id":"17047","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"17154","relation":"part_of_dissertation"}]},"author":[{"id":"e796e4f9-dc8d-11ea-abe3-97e26a0323e9","first_name":"Jana","full_name":"Reker, Jana","last_name":"Reker"}],"department":[{"_id":"GradSch"},{"_id":"LaEr"}],"project":[{"name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331"}],"abstract":[{"lang":"eng","text":"This thesis is structured into two parts. In the first part, we consider the random\r\nvariable X := Tr(f1(W)A1 . . . fk(W)Ak) where W is an N × N Hermitian Wigner matrix, k ∈ N, and we choose (possibly N-dependent) regular functions f1, . . . , fk as well as\r\nbounded deterministic matrices A1, . . . , Ak. In this context, we prove a functional central\r\nlimit theorem on macroscopic and mesoscopic scales, showing that the fluctuations of X\r\naround its expectation are Gaussian and that the limiting covariance structure is given\r\nby a deterministic recursion. We further give explicit error bounds in terms of the scaling\r\nof f1, . . . , fk and the number of traceless matrices among A1, . . . , Ak, thus extending\r\nthe results of Cipolloni, Erdős and Schröder [40] to products of arbitrary length k ≥ 2.\r\nAnalyzing the underlying combinatorics leads to a non-recursive formula for the variance\r\nof X as well as the covariance of X and Y := Tr(fk+1(W)Ak+1 . . . fk+ℓ(W)Ak+ℓ) of similar\r\nbuild. When restricted to polynomials, these formulas reproduce recent results of Male,\r\nMingo, Peché, and Speicher [107], showing that the underlying combinatorics of noncrossing partitions and annular non-crossing permutations continue to stay valid beyond\r\nthe setting of second-order free probability theory. As an application, we consider the\r\nfluctuation of Tr(eitW A1e\r\n−itW A2)/N around its thermal value Tr(A1) Tr(A2)/N2 when t\r\nis large and give an explicit formula for the variance.\r\nThe second part of the thesis collects three smaller projects focusing on different random\r\nmatrix models. In the first project, we show that a class of weakly perturbed Hamiltonians\r\nof the form Hλ = H0 + λW, where W is a Wigner matrix, exhibits prethermalization.\r\nThat is, the time evolution generated by Hλ relaxes to its ultimate thermal state via an\r\nintermediate prethermal state with a lifetime of order λ\r\n−2\r\n. As the main result, we obtain\r\na general relaxation formula, expressing the perturbed dynamics via the unperturbed\r\ndynamics and the ultimate thermal state. The proof relies on a two-resolvent global law\r\nfor the deformed Wigner matrix Hλ.\r\nThe second project focuses on correlated random matrices, more precisely on a correlated N × N Hermitian random matrix with a polynomially decaying metric correlation\r\nstructure. A trivial a priori bound shows that the operator norm of this model is stochastically dominated by √\r\nN. However, by calculating the trace of the moments of the matrix\r\nand using the summable decay of the cumulants, the norm estimate can be improved to a\r\nbound of order one.\r\nIn the third project, we consider a multiplicative perturbation of the form UA(t) where U\r\nis a unitary random matrix and A = diag(t, 1, ..., 1). This so-called UA model was\r\nfirst introduced by Fyodorov [73] for its applications in scattering theory. We give a\r\ngeneral description of the eigenvalue trajectories obtained by varying the parameter t and\r\nintroduce a flow of deterministic domains that separates the outlier resulting from the\r\nrank-one perturbation from the typical eigenvalues for all sub-critical timescales. The\r\nresults are obtained under generic assumptions on U that hold for various unitary random\r\nmatrices, including the circular unitary ensemble (CUE) in the original formulation of\r\nthe model."}],"article_processing_charge":"No","year":"2024","publisher":"Institute of Science and Technology Austria","month":"06","file_date_updated":"2024-06-26T12:44:53Z","doi_confirm":"1","type":"dissertation","publication_status":"published","supervisor":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","last_name":"Erdös","full_name":"Erdös, László"}],"date_published":"2024-06-26T00:00:00Z","status":"public","title":"Central limit theorems for random matrices: From resolvents to free probability","oa":1,"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","date_updated":"2026-10-16T08:35:03Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"17164","page":"206","file":[{"creator":"jreker","checksum":"fb16d86e1f2753dc3a9e14d2bdfd84cd","date_updated":"2024-06-26T12:44:53Z","file_id":"17176","file_size":2783027,"file_name":"ISTA_Thesis_JReker.pdf","relation":"main_file","content_type":"application/pdf","date_created":"2024-06-26T12:39:36Z","access_level":"open_access"},{"date_updated":"2024-06-26T12:44:53Z","file_id":"17177","file_size":3054878,"file_name":"ISTA_Thesis_JReker_SourceFiles.zip","relation":"source_file","content_type":"application/zip","date_created":"2024-06-26T12:39:42Z","access_level":"closed","creator":"jreker","checksum":"cb1e54009d47c1dcf5b866c4566fa27f"}],"citation":{"chicago":"Reker, Jana. “Central Limit Theorems for Random Matrices: From Resolvents to Free Probability.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:17164.","ama":"Reker J. Central limit theorems for random matrices: From resolvents to free probability. 2024. doi:10.15479/at:ista:17164","apa":"Reker, J. (2024). Central limit theorems for random matrices: From resolvents to free probability. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:17164","ista":"Reker J. 2024. Central limit theorems for random matrices: From resolvents to free probability. Institute of Science and Technology Austria.","short":"J. Reker, Central Limit Theorems for Random Matrices: From Resolvents to Free Probability, Institute of Science and Technology Austria, 2024.","ieee":"J. Reker, “Central limit theorems for random matrices: From resolvents to free probability,” Institute of Science and Technology Austria, 2024.","mla":"Reker, Jana. Central Limit Theorems for Random Matrices: From Resolvents to Free Probability. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:17164."},"date_created":"2024-06-24T11:23:29Z","keyword":["Random Matrices","Spectrum","Central Limit Theorem","Resolvent","Free Probability"],"language":[{"iso":"eng"}],"doi":"10.15479/at:ista:17164","degree_awarded":"PhD","ddc":["519"]},{"doi":"10.1016/j.jfa.2024.110495","language":[{"iso":"eng"}],"intvolume":" 287","isi":1,"ddc":["510"],"issue":"4","article_number":"110495","external_id":{"isi":["001325502400001"]},"quality_controlled":"1","date_created":"2024-05-26T22:00:57Z","acknowledgement":"Supported by ERC Advanced Grant “RMTBeyond” No. 101020331.\r\nSupported by the SNSF Ambizione Grant PZ00P2_209089.","_id":"17049","volume":287,"file":[{"checksum":"07d3f73e0c56e68eb110851842c22ee0","creator":"dernst","success":1,"file_name":"2025_JourFunctionalAnalysis_Cipolloni.pdf","content_type":"application/pdf","relation":"main_file","file_id":"19891","file_size":1374854,"date_updated":"2025-06-24T13:14:21Z","access_level":"open_access","date_created":"2025-06-24T13:14:21Z"}],"citation":{"apa":"Cipolloni, G., Erdös, L., Henheik, S. J., & Schröder, D. J. (2024). Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices. Journal of Functional Analysis. Elsevier. https://doi.org/10.1016/j.jfa.2024.110495","chicago":"Cipolloni, Giorgio, László Erdös, Sven Joscha Henheik, and Dominik J Schröder. “Optimal Lower Bound on Eigenvector Overlaps for Non-Hermitian Random Matrices.” Journal of Functional Analysis. Elsevier, 2024. https://doi.org/10.1016/j.jfa.2024.110495.","ama":"Cipolloni G, Erdös L, Henheik SJ, Schröder DJ. Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices. Journal of Functional Analysis. 2024;287(4). doi:10.1016/j.jfa.2024.110495","mla":"Cipolloni, Giorgio, et al. “Optimal Lower Bound on Eigenvector Overlaps for Non-Hermitian Random Matrices.” Journal of Functional Analysis, vol. 287, no. 4, 110495, Elsevier, 2024, doi:10.1016/j.jfa.2024.110495.","ieee":"G. Cipolloni, L. Erdös, S. J. Henheik, and D. J. Schröder, “Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices,” Journal of Functional Analysis, vol. 287, no. 4. Elsevier, 2024.","ista":"Cipolloni G, Erdös L, Henheik SJ, Schröder DJ. 2024. Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices. Journal of Functional Analysis. 287(4), 110495.","short":"G. Cipolloni, L. Erdös, S.J. Henheik, D.J. Schröder, Journal of Functional Analysis 287 (2024)."},"publication":"Journal of Functional Analysis","scopus_import":"1","date_updated":"2026-10-16T08:36:18Z","oa":1,"OA_type":"hybrid","title":"Optimal lower bound on eigenvector overlaps for non-Hermitian random matrices","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","type":"journal_article","file_date_updated":"2025-06-24T13:14:21Z","dataavailabilitystatement":"No data was used for the research described in the article.","date_published":"2024-08-15T00:00:00Z","status":"public","publication_status":"published","article_processing_charge":"Yes (via OA deal)","year":"2024","publisher":"Elsevier","project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020","grant_number":"101020331"}],"abstract":[{"lang":"eng","text":"We consider large non-Hermitian NxN matrices with an additive independent, identically distributed (i.i.d.) noise for each matrix elements. We show that already a small noise of variance 1/N completely thermalises the bulk singular vectors, in particular they satisfy the strong form of Quantum Unique Ergodicity (QUE) with an optimal speed of convergence. In physics terms, we thus extend the Eigenstate Thermalisation Hypothesis, formulated originally by Deutsch [34] and proven for Wigner matrices in [23], to arbitrary non-Hermitian matrices with an i.i.d. noise. As a consequence we obtain an optimal lower bound on the diagonal overlaps of the corresponding non-Hermitian eigenvectors. This quantity, also known as the (square of the) eigenvalue condition number measuring the sensitivity of the eigenvalue to small perturbations, has notoriously escaped rigorous treatment beyond the explicitly computable Ginibre ensemble apart from the very recent upper bounds given in [7] and [45]. As a key tool, we develop a new systematic decomposition of general observables in random matrix theory that governs the size of products of resolvents with deterministic matrices in between."}],"month":"08","corr_author":"1","fulldoi":"https://doi.org/10.1016/j.jfa.2024.110495","ec_funded":1,"OA_place":"publisher","related_material":{"record":[{"id":"19540","relation":"dissertation_contains","status":"public"}]},"researchdata_availability":"not applicable","author":[{"last_name":"Cipolloni","full_name":"Cipolloni, Giorgio","id":"42198EFA-F248-11E8-B48F-1D18A9856A87","first_name":"Giorgio","orcid":"0000-0002-4901-7992"},{"last_name":"Erdös","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603"},{"last_name":"Henheik","full_name":"Henheik, Sven Joscha","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","orcid":"0000-0003-1106-327X","first_name":"Sven Joscha"},{"id":"408ED176-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik J","orcid":"0000-0002-2904-1856","last_name":"Schröder","full_name":"Schröder, Dominik J"}],"department":[{"_id":"LaEr"}],"article_type":"original","supplementarymaterial":"yes","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","publication_identifier":{"eissn":["1096-0783"],"issn":["0022-1236"]},"das_tickbox":"1","day":"15","has_accepted_license":"1"},{"file_date_updated":"2025-01-09T09:36:41Z","type":"journal_article","publication_status":"published","status":"public","date_published":"2024-09-01T00:00:00Z","abstract":[{"lang":"eng","text":"We consider N×N non-Hermitian random matrices of the form X+A, where A is a general deterministic matrix and N−−√X consists of independent entries with zero mean, unit variance, and bounded densities. For this ensemble, we prove (i) a Wegner estimate, i.e. that the local density of eigenvalues is bounded by N1+o(1) and (ii) that the expected condition number of any bulk eigenvalue is bounded by N1+o(1); both results are optimal up to the factor No(1). The latter result complements the very recent matching lower bound obtained in [15] (arXiv:2301.03549) and improves the N-dependence of the upper bounds in [5,6,32] (arXiv:1906.11819, arXiv:2005.08930, arXiv:2005.08908). Our main ingredient, a near-optimal lower tail estimate for the small singular values of X+A−z, is of independent interest."}],"project":[{"grant_number":"101020331","name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d"}],"publisher":"Wiley","article_processing_charge":"Yes (via OA deal)","year":"2024","month":"09","ec_funded":1,"OA_place":"publisher","fulldoi":"https://doi.org/10.1002/cpa.22201","corr_author":"1","article_type":"original","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","last_name":"Erdös","full_name":"Erdös, László"},{"id":"dd216c0a-c1f9-11eb-beaf-e9ea9d2de76d","first_name":"Hong Chang","last_name":"Ji","full_name":"Ji, Hong Chang"}],"department":[{"_id":"LaEr"}],"researchdata_availability":"no","publication_identifier":{"issn":["0010-3640"],"eissn":["1097-0312"]},"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"supplementarymaterial":"yes","day":"01","has_accepted_license":"1","das_tickbox":"0","language":[{"iso":"eng"}],"doi":"10.1002/cpa.22201","ddc":["510"],"isi":1,"intvolume":" 77","external_id":{"isi":["001217139900001"],"arxiv":["2301.04981"]},"issue":"9","date_created":"2024-05-12T22:01:02Z","acknowledgement":"László Erdős is partially supported by ERC Advanced Grant “RMTBeyond” No. 101020331. Hong Chang Ji is supported by ERC Advanced Grant “RMTBeyond” No. 101020331.","quality_controlled":"1","_id":"15378","volume":77,"page":"3785-3840","publication":"Communications on Pure and Applied Mathematics","arxiv":1,"file":[{"success":1,"creator":"dernst","checksum":"fbcc9cc7bf274f024e4f4afc9c208f96","access_level":"open_access","date_created":"2025-01-09T09:36:41Z","date_updated":"2025-01-09T09:36:41Z","file_name":"2024_CommPureApplMath_Erdoes.pdf","relation":"main_file","content_type":"application/pdf","file_size":566963,"file_id":"18803"}],"citation":{"mla":"Erdös, László, and Hong Chang Ji. “Wegner Estimate and Upper Bound on the Eigenvalue Condition Number of Non-Hermitian Random Matrices.” Communications on Pure and Applied Mathematics, vol. 77, no. 9, Wiley, 2024, pp. 3785–840, doi:10.1002/cpa.22201.","ieee":"L. Erdös and H. C. Ji, “Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices,” Communications on Pure and Applied Mathematics, vol. 77, no. 9. Wiley, pp. 3785–3840, 2024.","short":"L. Erdös, H.C. Ji, Communications on Pure and Applied Mathematics 77 (2024) 3785–3840.","ista":"Erdös L, Ji HC. 2024. Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices. Communications on Pure and Applied Mathematics. 77(9), 3785–3840.","apa":"Erdös, L., & Ji, H. C. (2024). Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices. Communications on Pure and Applied Mathematics. Wiley. https://doi.org/10.1002/cpa.22201","ama":"Erdös L, Ji HC. Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices. Communications on Pure and Applied Mathematics. 2024;77(9):3785-3840. doi:10.1002/cpa.22201","chicago":"Erdös, László, and Hong Chang Ji. “Wegner Estimate and Upper Bound on the Eigenvalue Condition Number of Non-Hermitian Random Matrices.” Communications on Pure and Applied Mathematics. Wiley, 2024. https://doi.org/10.1002/cpa.22201."},"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","OA_type":"hybrid","oa":1,"title":"Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices","date_updated":"2026-10-16T08:35:46Z","scopus_import":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","scopus_import":"1","date_updated":"2026-10-16T08:38:43Z","oa":1,"title":"Multi-point functional central limit theorem for Wigner matrices","OA_type":"gold","DOAJ_listed":"1","arxiv":1,"citation":{"short":"J. Reker, Electronic Journal of Probability 29 (2024).","ista":"Reker J. 2024. Multi-point functional central limit theorem for Wigner matrices. Electronic Journal of Probability. 29, 191.","ieee":"J. Reker, “Multi-point functional central limit theorem for Wigner matrices,” Electronic Journal of Probability, vol. 29. Institute of Mathematical Statistics, 2024.","mla":"Reker, Jana. “Multi-Point Functional Central Limit Theorem for Wigner Matrices.” Electronic Journal of Probability, vol. 29, 191, Institute of Mathematical Statistics, 2024, doi:10.1214/24-EJP1247.","ama":"Reker J. Multi-point functional central limit theorem for Wigner matrices. Electronic Journal of Probability. 2024;29. doi:10.1214/24-EJP1247","chicago":"Reker, Jana. “Multi-Point Functional Central Limit Theorem for Wigner Matrices.” Electronic Journal of Probability. Institute of Mathematical Statistics, 2024. https://doi.org/10.1214/24-EJP1247.","apa":"Reker, J. (2024). Multi-point functional central limit theorem for Wigner matrices. Electronic Journal of Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/24-EJP1247"},"file":[{"success":1,"creator":"dernst","checksum":"67178feaa8630a332599d3037a3fe70e","access_level":"open_access","date_created":"2025-01-08T08:44:03Z","date_updated":"2025-01-08T08:44:03Z","file_name":"2024_ElectrJournProbability_Reker.pdf","content_type":"application/pdf","relation":"main_file","file_id":"18773","file_size":812428}],"publication":"Electronic Journal of Probability","volume":29,"_id":"18762","quality_controlled":"1","acknowledgement":"I am very grateful to László Erdős for suggesting the topic and many valuable discussions during my work on the project. I would also like to thank the two anonymous referees for their careful reading of the manuscript and detailed feedback.\r\nPartially supported by ERC Advanced Grants “RMTBeyond” No. 101020331 and “LDRaM” No. 884584.","date_created":"2025-01-05T23:01:58Z","article_number":"191","external_id":{"arxiv":["2307.11028"],"isi":["001381599200001"]},"intvolume":" 29","isi":1,"ddc":["510"],"doi":"10.1214/24-EJP1247","language":[{"iso":"eng"}],"das_tickbox":"0","day":"20","has_accepted_license":"1","supplementarymaterial":"no","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_identifier":{"eissn":["1083-6489"]},"related_material":{"record":[{"status":"public","id":"17173","relation":"earlier_version"}]},"researchdata_availability":"no","department":[{"_id":"LaEr"}],"author":[{"last_name":"Reker","full_name":"Reker, Jana","id":"e796e4f9-dc8d-11ea-abe3-97e26a0323e9","first_name":"Jana"}],"article_type":"original","corr_author":"1","fulldoi":"https://doi.org/10.1214/24-EJP1247","OA_place":"publisher","ec_funded":1,"month":"12","year":"2024","article_processing_charge":"Yes","publisher":"Institute of Mathematical Statistics","project":[{"name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331"}],"abstract":[{"text":"Consider the random variable $\\mathrm{Tr}( f_1(W)A_1\\dots f_k(W)A_k)$ where $W$ is an $N\\times N$ Hermitian Wigner matrix, $k\\in\\mathbb{N}$, and choose (possibly $N$-dependent) regular functions $f_1,\\dots, f_k$ as well as bounded deterministic matrices $A_1,\\dots,A_k$. We give a functional central limit theorem showing that the fluctuations around the expectation are Gaussian. Moreover, we determine the limiting covariance structure and give explicit error bounds in terms of the scaling of $f_1,\\dots,f_k$ and the number of traceless matrices among $A_1,\\dots,A_k$, thus extending the results of [Cipolloni, Erdős, Schröder 2023] to products of arbitrary length $k\\geq2$. As an application, we consider the fluctuation of $\\mathrm{Tr}(\\mathrm{e}^{\\mathrm{i} tW}A_1\\mathrm{e}^{-\\mathrm{i} tW}A_2)$ around its thermal value $\\mathrm{Tr}(A_1)\\mathrm{Tr}(A_2)$ when $t$ is large and give an explicit formula for the variance.","lang":"eng"}],"date_published":"2024-12-20T00:00:00Z","status":"public","publication_status":"published","type":"journal_article","file_date_updated":"2025-01-08T08:44:03Z"},{"publication_identifier":{"issn":["1385-0172"],"eissn":["1572-9656"]},"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"supplementarymaterial":"yes","has_accepted_license":"1","day":"20","das_tickbox":"1","ec_funded":1,"fulldoi":"https://doi.org/10.1007/s11040-024-09483-y","article_type":"original","department":[{"_id":"LaEr"}],"author":[{"id":"e796e4f9-dc8d-11ea-abe3-97e26a0323e9","first_name":"Jana","full_name":"Reker, Jana","last_name":"Reker"}],"researchdata_availability":"not applicable","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"17164"}]},"abstract":[{"text":"We compute the deterministic approximation for mixed fluctuation moments of products of deterministic matrices and general Sobolev functions of Wigner matrices. Restricting to polynomials, our formulas reproduce recent results of Male et al. (Random Matrices Theory Appl. 11(2):2250015, 2022), showing that the underlying combinatorics of non-crossing partitions and annular non-crossing permutations continue to stay valid beyond the setting of second-order free probability theory. The formulas obtained further characterize the variance in the functional central limit theorem given in the recent companion paper (Reker in Preprint, arXiv:2204.03419, 2023). and thus allow identifying the fluctuation around the thermal value in certain thermalization problems.","lang":"eng"}],"project":[{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"},{"grant_number":"101020331","_id":"62796744-2b32-11ec-9570-940b20777f1d","name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020"}],"publisher":"Springer Nature","article_processing_charge":"Yes (via OA deal)","year":"2024","month":"06","file_date_updated":"2024-06-26T11:26:42Z","type":"journal_article","publication_status":"published","date_published":"2024-06-20T00:00:00Z","status":"public","dataavailabilitystatement":"Data sharing not applicable to this article as no datasets were generated or analysed during the current study.","title":"Fluctuation moments for regular functions of Wigner Matrices","oa":1,"date_updated":"2026-10-16T08:35:04Z","scopus_import":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"17154","volume":27,"publication":"Mathematical Physics, Analysis and Geometry","arxiv":1,"file":[{"access_level":"open_access","date_created":"2024-06-26T11:26:42Z","date_updated":"2024-06-26T11:26:42Z","relation":"main_file","content_type":"application/pdf","file_name":"2024_MathPhysAnaGeo_Reker.pdf","file_id":"17175","file_size":1327596,"success":1,"creator":"cchlebak","checksum":"7d04318d66f765621bdcb648378d458e"}],"citation":{"mla":"Reker, Jana. “Fluctuation Moments for Regular Functions of Wigner Matrices.” Mathematical Physics, Analysis and Geometry, vol. 27, no. 3, 10, Springer Nature, 2024, doi:10.1007/s11040-024-09483-y.","ieee":"J. Reker, “Fluctuation moments for regular functions of Wigner Matrices,” Mathematical Physics, Analysis and Geometry, vol. 27, no. 3. Springer Nature, 2024.","short":"J. Reker, Mathematical Physics, Analysis and Geometry 27 (2024).","ista":"Reker J. 2024. Fluctuation moments for regular functions of Wigner Matrices. Mathematical Physics, Analysis and Geometry. 27(3), 10.","apa":"Reker, J. (2024). Fluctuation moments for regular functions of Wigner Matrices. Mathematical Physics, Analysis and Geometry. Springer Nature. https://doi.org/10.1007/s11040-024-09483-y","ama":"Reker J. Fluctuation moments for regular functions of Wigner Matrices. Mathematical Physics, Analysis and Geometry. 2024;27(3). doi:10.1007/s11040-024-09483-y","chicago":"Reker, Jana. “Fluctuation Moments for Regular Functions of Wigner Matrices.” Mathematical Physics, Analysis and Geometry. Springer Nature, 2024. https://doi.org/10.1007/s11040-024-09483-y."},"external_id":{"arxiv":["2307.11029"],"isi":["001251464300001"]},"issue":"3","article_number":"10","date_created":"2024-06-21T09:31:17Z","quality_controlled":"1","language":[{"iso":"eng"}],"doi":"10.1007/s11040-024-09483-y","ddc":["519"],"isi":1,"intvolume":" 27"},{"quality_controlled":"1","date_created":"2024-12-15T23:01:51Z","acknowledgement":"LE and JH were supported by the ERC Advanced Grant łRMTBeyondž No. 101020331","issue":"6","external_id":{"arxiv":["2402.17609"]},"intvolume":" 28","doi":"10.4310/ATMP.241031013250","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2402.17609","open_access":"1"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2026-10-16T08:35:25Z","scopus_import":"1","title":"Out-of-time-ordered correlators for Wigner matrices","OA_type":"green","oa":1,"citation":{"apa":"Cipolloni, G., Erdös, L., & Henheik, S. J. (2024). Out-of-time-ordered correlators for Wigner matrices. Advances in Theoretical and Mathematical Physics. International Press of Boston. https://doi.org/10.4310/ATMP.241031013250","ama":"Cipolloni G, Erdös L, Henheik SJ. Out-of-time-ordered correlators for Wigner matrices. Advances in Theoretical and Mathematical Physics. 2024;28(6):2025-2083. doi:10.4310/ATMP.241031013250","chicago":"Cipolloni, Giorgio, László Erdös, and Sven Joscha Henheik. “Out-of-Time-Ordered Correlators for Wigner Matrices.” Advances in Theoretical and Mathematical Physics. International Press of Boston, 2024. https://doi.org/10.4310/ATMP.241031013250.","ieee":"G. Cipolloni, L. Erdös, and S. J. Henheik, “Out-of-time-ordered correlators for Wigner matrices,” Advances in Theoretical and Mathematical Physics, vol. 28, no. 6. International Press of Boston, pp. 2025–2083, 2024.","mla":"Cipolloni, Giorgio, et al. “Out-of-Time-Ordered Correlators for Wigner Matrices.” Advances in Theoretical and Mathematical Physics, vol. 28, no. 6, International Press of Boston, 2024, pp. 2025–83, doi:10.4310/ATMP.241031013250.","short":"G. Cipolloni, L. Erdös, S.J. Henheik, Advances in Theoretical and Mathematical Physics 28 (2024) 2025–2083.","ista":"Cipolloni G, Erdös L, Henheik SJ. 2024. Out-of-time-ordered correlators for Wigner matrices. Advances in Theoretical and Mathematical Physics. 28(6), 2025–2083."},"arxiv":1,"publication":"Advances in Theoretical and Mathematical Physics","page":"2025-2083","volume":28,"_id":"18656","month":"10","publisher":"International Press of Boston","year":"2024","article_processing_charge":"No","abstract":[{"lang":"eng","text":"We consider the time evolution of the out-of-time-ordered correlator (OTOC) of two general observables \r\n and \r\n in a mean field chaotic quantum system described by a random Wigner matrix as its Hamiltonian. We rigorously identify three time regimes separated by the physically relevant scrambling and relaxation times. The main feature of our analysis is that we express the error terms in the optimal Schatten (tracial) norms of the observables, allowing us to track the exact dependence of the errors on their rank. In particular, for significantly overlapping observables with low rank the OTOC is shown to exhibit a significant local maximum at the scrambling time, a feature that may not have been noticed in the physics literature before. Our main tool is a novel multi-resolvent local law with Schatten norms that unifies and improves previous local laws involving either the much cruder operator norm (cf. [10]) or the Hilbert-Schmidt norm (cf. [11])."}],"project":[{"grant_number":"101020331","_id":"62796744-2b32-11ec-9570-940b20777f1d","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta"}],"status":"public","date_published":"2024-10-30T00:00:00Z","publication_status":"published","type":"journal_article","das_tickbox":"1","day":"30","oa_version":"Preprint","supplementarymaterial":"unclear","publication_identifier":{"eissn":["1095-0753"],"issn":["1095-0761"]},"department":[{"_id":"LaEr"}],"author":[{"full_name":"Cipolloni, Giorgio","last_name":"Cipolloni","first_name":"Giorgio","orcid":"0000-0002-4901-7992","id":"42198EFA-F248-11E8-B48F-1D18A9856A87"},{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","first_name":"László","last_name":"Erdös","full_name":"Erdös, László"},{"orcid":"0000-0003-1106-327X","first_name":"Sven Joscha","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","full_name":"Henheik, Sven Joscha","last_name":"Henheik"}],"researchdata_availability":"unclear","related_material":{"record":[{"status":"public","id":"19540","relation":"dissertation_contains"}]},"article_type":"original","fulldoi":"https://doi.org/10.4310/ATMP.241031013250","corr_author":"1","OA_place":"repository","ec_funded":1},{"date_created":"2024-07-26T09:05:55Z","language":[{"iso":"eng"}],"doi":"10.15479/at:ista:17319","ddc":["580"],"degree_awarded":"PhD","title":"Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku'amide B","oa":1,"acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"LifeSc"}],"date_updated":"2026-10-16T08:50:36Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"17319","page":"224","citation":{"ama":"Lukic K. Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku’amide B. 2024. doi:10.15479/at:ista:17319","chicago":"Lukic, Kristina. “Membrane Proteins in Plant Physiology and Bioenergetics : Investigating Auxin Efflux Transporter PIN8 and ATP Synthase Inhibition by the Novel Inhibitor Yaku’amide B.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:17319.","apa":"Lukic, K. (2024). Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku’amide B. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:17319","short":"K. Lukic, Membrane Proteins in Plant Physiology and Bioenergetics : Investigating Auxin Efflux Transporter PIN8 and ATP Synthase Inhibition by the Novel Inhibitor Yaku’amide B, Institute of Science and Technology Austria, 2024.","ista":"Lukic K. 2024. Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku’amide B. Institute of Science and Technology Austria.","ieee":"K. Lukic, “Membrane proteins in plant physiology and bioenergetics : Investigating auxin efflux transporter PIN8 and ATP synthase inhibition by the novel inhibitor Yaku’amide B,” Institute of Science and Technology Austria, 2024.","mla":"Lukic, Kristina. Membrane Proteins in Plant Physiology and Bioenergetics : Investigating Auxin Efflux Transporter PIN8 and ATP Synthase Inhibition by the Novel Inhibitor Yaku’amide B. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:17319."},"file":[{"date_created":"2024-07-26T13:14:24Z","access_level":"open_access","date_updated":"2025-01-26T23:30:04Z","file_id":"17320","file_size":24639084,"relation":"main_file","content_type":"application/pdf","file_name":"Thesis_Kristina_Lukic.pdf","creator":"cchlebak","embargo":"2025-01-26","checksum":"95517e697ea6a87e267e649cad560989"},{"date_created":"2024-07-26T13:14:50Z","access_level":"closed","date_updated":"2025-01-26T23:30:04Z","file_id":"17321","file_size":96334272,"relation":"source_file","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"Thesis_Kristina_Lukic.docx","embargo_to":"open_access","creator":"cchlebak","checksum":"74325746a9a05078fb9935dbf2aef752"}],"abstract":[{"lang":"eng","text":"This thesis comprises two distinct projects, each offering unique insights into fundamental\r\ncellular processes. While distinct in their focus, these different perspectives have a common\r\ntheme: chemiosmotic theory and utilisation of the proton gradient for driving the essential\r\nprocesses like auxin efflux and ATP synthesis, effectively bridging the membrane protein\r\nstructure and function from the realms of plant biology and cellular bioenergetics.\r\nThe first project of this thesis centres on the characterisation of PIN proteins, a class of\r\ntransmembrane transporters pivotal in the regulation of auxin transport and distribution in\r\nplants. PINs form a conserved and phylogenetically abundant group of transporters present in\r\nland plants and certain algae. Despite their great importance, they were one of the few elusive\r\nproteins essential for plant development not to be structurally and mechanistically\r\ncharacterised since their discovery almost 30 years ago. This work aimed to uncover the\r\nstructural and functional dynamics of the PIN protein-mediated auxin transport using an array\r\nof experimental techniques, including protein purification, biochemical assays and structural\r\nanalysis. Through an exhaustive screening process that took several years and included testing\r\ndifferent PIN homologues, expression systems, constructs, and purification conditions, we\r\ndeveloped a robust protocol for isolating the pure, stable, and monodisperse PIN8 protein.\r\nMoreover, utilising biophysical methods and buffer screening, we demonstrated that PIN8\r\nexhibits detergent and pH-dependent stability, with mild detergents and lower pH (5.0 and 6.0)\r\nbeing optimal for the stability of the protein. Using SEC-MALS and crosslinking, we\r\ndetermined that PIN8 forms dimers, which was confirmed by our structural studies. We\r\nobtained a cryo-EM map of PIN8 at pH 6.0, and, compared to recently published structures,\r\nour map implies major pH-dependent conformational changes and possibly utilisation of the\r\nproton gradient in the transport mechanism.\r\nThe subject of the second project was F1Fo-ATP synthase, an enzyme complex fundamental\r\nto cellular energy metabolism. Through an approach integrating biochemical assays and\r\nstructural analysis, this research aimed to unveil the molecular mechanism of inhibition of ATP\r\nsynthase by yaku´amide, a bioactive compound with potential therapeutic implications. Using\r\nsubmitochondrial particles and purified F1Fo-ATP synthase, we demonstrated that, contrary to\r\npublished data, yaku´amide inhibits both ATP hydrolysis and ATP synthesis reactions.\r\nMoreover, we found that yaku´amide inhibitory activity is proton motive force (pmf)\r\ndependent, with lower inhibition in a more coupled system. Utilising cryo-EM, we obtained\r\nmaps and models for the three main rotational states of murine ATP synthase (State 1 at 3.0 Å,\r\n8\r\nState 2 at 3.1 Å, and State 3 at 3.2 Å, overall). We observed several new features in our maps;\r\nhowever, we cannot definitively determine the exact mechanism of yaku amide’s inhibition on\r\nthe protein due to either resolution limits or suboptimal binding of the inhibitor."}],"article_processing_charge":"No","year":"2024","publisher":"Institute of Science and Technology Austria","month":"07","file_date_updated":"2025-01-26T23:30:04Z","doi_confirm":"1","type":"dissertation","publication_status":"published","supervisor":[{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989","first_name":"Leonid A","last_name":"Sazanov","full_name":"Sazanov, Leonid A"}],"status":"public","date_published":"2024-07-26T00:00:00Z","publication_identifier":{"issn":["2663-337X"]},"supplementarymaterial":"no","oa_version":"Published Version","has_accepted_license":"1","day":"26","das_tickbox":"0","OA_place":"publisher","corr_author":"1","fulldoi":"https://doi.org/10.15479/at:ista:17319","alternative_title":["ISTA Thesis"],"researchdata_availability":"no","author":[{"last_name":"Lukic","full_name":"Lukic, Kristina","id":"2B04DB84-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1581-881X","first_name":"Kristina"}],"department":[{"_id":"LeSa"},{"_id":"GradSch"}]},{"type":"journal_article","file_date_updated":"2024-07-29T11:02:48Z","date_published":"2024-07-15T00:00:00Z","status":"public","publication_status":"published","publisher":"IOP Publishing","article_processing_charge":"Yes","year":"2024","abstract":[{"text":"Magnetic fields in the stellar interiors are key candidates to explain observed core rotation rates inside solar-like stars along their evolution. Recently, asteroseismic estimates of radial magnetic field amplitudes near the hydrogen-burning shell (H-shell) inside about 24 red giants (RGs) have been obtained by measuring frequency splittings from their power spectra. Using general Lorentz-stress (magnetic) kernels, we investigated the potential for detectability of near-surface magnetism in a 1.3 M⊙ star of supersolar metallicity as it evolves from a mid subgiant to a late subgiant into an RG. Based on these sensitivity kernels, we decompose an RG into three zones—deep core, H-shell, and near-surface. The subgiants instead required decomposition into an inner core, an outer core, and a near-surface layer. Additionally, we find that for a low-frequency g-dominated dipolar mode in the presence of a typical stable magnetic field, ∼25% of the frequency shift comes from the H-shell and the remaining from deeper layers. The ratio of the subsurface tangential field to the radial field in the H-burning shell decides if subsurface fields may be potentially detectable. For p-dominated dipole modes close to vmax, this ratio is around two orders of magnitude smaller in subgiant phases than the corresponding RG. Further, with the availability of magnetic kernels, we propose lower limits of field strengths in crucial layers in our stellar model during its evolutionary phases. The theoretical prescription outlined here provides the first formal way to devise inverse problems for stellar magnetism and can be seamlessly employed for slow rotators.","lang":"eng"}],"project":[{"call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413"}],"month":"07","fulldoi":"https://doi.org/10.3847/1538-4357/ad4708","ec_funded":1,"department":[{"_id":"LiBu"}],"author":[{"first_name":"Shatanik","last_name":"Bhattacharya","full_name":"Bhattacharya, Shatanik"},{"full_name":"Das, Srijan B","last_name":"Das","first_name":"Srijan B","orcid":"0000-0003-0896-7972","id":"9ce7c423-dacf-11ed-8942-e09c6cb27149"},{"full_name":"Bugnet, Lisa Annabelle","last_name":"Bugnet","id":"d9edb345-f866-11ec-9b37-d119b5234501","first_name":"Lisa Annabelle","orcid":"0000-0003-0142-4000"},{"first_name":"Subrata","full_name":"Panda, Subrata","last_name":"Panda"},{"first_name":"Shravan M.","last_name":"Hanasoge","full_name":"Hanasoge, Shravan M."}],"researchdata_availability":"yes","article_type":"original","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"supplementarymaterial":"yes","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"das_tickbox":"0","day":"15","has_accepted_license":"1","doi":"10.3847/1538-4357/ad4708","language":[{"iso":"eng"}],"isi":1,"intvolume":" 970","ddc":["520"],"article_number":"42","issue":"1","external_id":{"arxiv":["2404.17167"],"isi":["001270972500001"]},"quality_controlled":"1","date_created":"2024-07-28T22:01:09Z","acknowledgement":"This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 101034413. S.\r\nB.D. acknowledges Prof. Jeroen Tromp at Princeton University for supporting a part of this work. S.M.H., S.B., and S.P. acknowledge support from the Department of Atomic Energy,\r\nGovernment of India, under Project Identification No. RTI 4002. The authors would like to thank the reviewer(s) and data editor for their constructive comments and suggestions. The\r\ngeneration of the stellar models was done using the Modules for Experiments in Stellar Astrophysics (MESA Paxton et al. 2011, 2013, 2015, 2018, 2019; we have used MESA version\r\nr22.05.1 for RG and r23.05.1 for SG models, MESA-SDK version x86_64-linux-22.6.1). The eigenfrequencies and eigenfunctions for this model were calculated using the GYRE\r\n(Townsend & Teitler 2013) code. The code to calculate the kernels and the splittings has been written completely in Python 3.8.16.","_id":"17326","volume":970,"citation":{"apa":"Bhattacharya, S., Das, S. B., Bugnet, L. A., Panda, S., & Hanasoge, S. M. (2024). Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars. Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ad4708","chicago":"Bhattacharya, Shatanik, Srijan B Das, Lisa Annabelle Bugnet, Subrata Panda, and Shravan M. Hanasoge. “Detectability of Axisymmetric Magnetic Fields from the Core to the Surface of Oscillating Post-Main-Sequence Stars.” Astrophysical Journal. IOP Publishing, 2024. https://doi.org/10.3847/1538-4357/ad4708.","ama":"Bhattacharya S, Das SB, Bugnet LA, Panda S, Hanasoge SM. Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars. Astrophysical Journal. 2024;970(1). doi:10.3847/1538-4357/ad4708","ieee":"S. Bhattacharya, S. B. Das, L. A. Bugnet, S. Panda, and S. M. Hanasoge, “Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars,” Astrophysical Journal, vol. 970, no. 1. IOP Publishing, 2024.","mla":"Bhattacharya, Shatanik, et al. “Detectability of Axisymmetric Magnetic Fields from the Core to the Surface of Oscillating Post-Main-Sequence Stars.” Astrophysical Journal, vol. 970, no. 1, 42, IOP Publishing, 2024, doi:10.3847/1538-4357/ad4708.","ista":"Bhattacharya S, Das SB, Bugnet LA, Panda S, Hanasoge SM. 2024. Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars. Astrophysical Journal. 970(1), 42.","short":"S. Bhattacharya, S.B. Das, L.A. Bugnet, S. Panda, S.M. Hanasoge, Astrophysical Journal 970 (2024)."},"arxiv":1,"file":[{"success":1,"checksum":"acb42a87deecbc9228fbbe6a48a37ec6","creator":"dernst","date_created":"2024-07-29T11:02:48Z","access_level":"open_access","file_id":"17340","file_size":3912290,"file_name":"2024_AstrophysicalJourn_Bhattacharya.pdf","content_type":"application/pdf","relation":"main_file","date_updated":"2024-07-29T11:02:48Z"}],"publication":"Astrophysical Journal","date_updated":"2026-10-16T08:51:03Z","scopus_import":"1","DOAJ_listed":"1","title":"Detectability of axisymmetric magnetic fields from the core to the surface of oscillating post-main-sequence stars","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"supplementarymaterial":"yes","publication_identifier":{"issn":["0035-8711"],"eissn":["1365-2966"]},"das_tickbox":"1","has_accepted_license":"1","day":"01","fulldoi":"https://doi.org/10.1093/mnras/stae2053","OA_place":"publisher","author":[{"first_name":"Emily J.","full_name":"Hatt, Emily J.","last_name":"Hatt"},{"first_name":"J. M.Joel","full_name":"Ong, J. M.Joel","last_name":"Ong"},{"first_name":"Martin B.","full_name":"Nielsen, Martin B.","last_name":"Nielsen"},{"first_name":"William J.","last_name":"Chaplin","full_name":"Chaplin, William J."},{"full_name":"Davies, Guy R.","last_name":"Davies","first_name":"Guy R."},{"first_name":"Sébastien","full_name":"Deheuvels, Sébastien","last_name":"Deheuvels"},{"last_name":"Ballot","full_name":"Ballot, Jérôme","first_name":"Jérôme"},{"last_name":"Li","full_name":"Li, Gang","first_name":"Gang"},{"last_name":"Bugnet","full_name":"Bugnet, Lisa Annabelle","orcid":"0000-0003-0142-4000","first_name":"Lisa Annabelle","id":"d9edb345-f866-11ec-9b37-d119b5234501"}],"department":[{"_id":"LiBu"}],"researchdata_availability":"yes","article_type":"original","publisher":"Oxford University Press","PlanS_conform":"1","article_processing_charge":"Yes","year":"2024","abstract":[{"text":"Red Giant stars host solar-like oscillations which have mixed character, being sensitive to conditions both in the outer convection zone and deep within the interior. The properties of these modes are sensitive to both core rotation and magnetic fields. While asteroseismic studies of the former have been done on a large scale, studies of the latter are currently limited to tens of stars. We aim to produce the first large catalogue of both magnetic and rotational perturbations. We jointly constrain these parameters by devising an automated method for fitting the power spectra directly. We successfully apply the method to 302 low-luminosity red giants. We find a clear bimodality in core rotation rate. The primary peak is at δνrot = 0.32 μHz, and the secondary at δνrot = 0.47 μHz. Combining our results with literature values, we find that the percentage of stars rotating much more rapidly than the population average increases with evolutionary state. We measure magnetic splittings of 2σ significance in 23 stars. While the most extreme magnetic splitting values appear in stars with masses > 1.1M⊙, implying they formerly hosted a convective core, a small but statistically significant magnetic splitting is measured at lower masses. Asymmetry between the frequencies of a rotationally split multiplet has previously been used to diagnose the presence of a magnetic perturbation. We find that of the stars with a significant detection of magnetic perturbation, 43\\% do not show strong asymmetry. We find no strong evidence of correlation between the rotation and magnetic parameters.","lang":"eng"}],"month":"10","type":"journal_article","file_date_updated":"2024-10-07T09:14:03Z","date_published":"2024-10-01T00:00:00Z","status":"public","dataavailabilitystatement":"Table 1 is available at the CDS. Light curves used in this work are available at Mikulski Archive for Space Telescopes at the Space Telescope Science Institute (MAST)1. Other intermediate data products will be made available upon reasonable request.","publication_status":"published","date_updated":"2026-10-16T08:52:08Z","scopus_import":"1","DOAJ_listed":"1","OA_type":"gold","oa":1,"title":"Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"1060-1076","volume":534,"_id":"18172","file":[{"content_type":"application/pdf","file_name":"2024_MonthlyNRoyalAstronSoc_Hatt.pdf","relation":"main_file","file_size":2813008,"file_id":"18182","date_updated":"2024-10-07T09:14:03Z","access_level":"open_access","date_created":"2024-10-07T09:14:03Z","checksum":"b79f3c6a5991516abbcc8d34fa4bfb5f","creator":"dernst","success":1}],"citation":{"ista":"Hatt EJ, Ong JMJ, Nielsen MB, Chaplin WJ, Davies GR, Deheuvels S, Ballot J, Li G, Bugnet LA. 2024. Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants. Monthly Notices of the Royal Astronomical Society. 534(2), 1060–1076.","short":"E.J. Hatt, J.M.J. Ong, M.B. Nielsen, W.J. Chaplin, G.R. Davies, S. Deheuvels, J. Ballot, G. Li, L.A. Bugnet, Monthly Notices of the Royal Astronomical Society 534 (2024) 1060–1076.","ieee":"E. J. Hatt et al., “Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants,” Monthly Notices of the Royal Astronomical Society, vol. 534, no. 2. Oxford University Press, pp. 1060–1076, 2024.","mla":"Hatt, Emily J., et al. “Asteroseismic Signatures of Core Magnetism and Rotation in Hundreds of Low-Luminosity Red Giants.” Monthly Notices of the Royal Astronomical Society, vol. 534, no. 2, Oxford University Press, 2024, pp. 1060–76, doi:10.1093/mnras/stae2053.","chicago":"Hatt, Emily J., J. M.Joel Ong, Martin B. Nielsen, William J. Chaplin, Guy R. Davies, Sébastien Deheuvels, Jérôme Ballot, Gang Li, and Lisa Annabelle Bugnet. “Asteroseismic Signatures of Core Magnetism and Rotation in Hundreds of Low-Luminosity Red Giants.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2024. https://doi.org/10.1093/mnras/stae2053.","ama":"Hatt EJ, Ong JMJ, Nielsen MB, et al. Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants. Monthly Notices of the Royal Astronomical Society. 2024;534(2):1060-1076. doi:10.1093/mnras/stae2053","apa":"Hatt, E. J., Ong, J. M. J., Nielsen, M. B., Chaplin, W. J., Davies, G. R., Deheuvels, S., … Bugnet, L. A. (2024). Asteroseismic signatures of core magnetism and rotation in hundreds of low-luminosity red giants. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stae2053"},"arxiv":1,"publication":"Monthly Notices of the Royal Astronomical Society","issue":"2","external_id":{"arxiv":["2409.01157"],"isi":["001320536900011"]},"quality_controlled":"1","date_created":"2024-10-06T22:01:11Z","acknowledgement":"EJH, WJC, and GRD acknowledge the support of Science and Technology Facilities Council. MBN acknowledges support from the UK Space Agency. JMJO acknowledges support from NASA through the NASA Hubble Fellowship grant HST-HF2-51517.001, awarded by STScI (Space Telescope Science Institute), which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. The authors acknowledge use of the Blue-BEAR HPC service at the University of Birmingham. This paper includes data collected by the Kepler mission and obtained from the MAST data archive at the Space Telescope Science Institute (STScI). Funding for the Kepler mission was provided by the NASA Science Mission Directorate. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/web/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC was provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. This paper received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (CartographY GA. 804752). SD and JB acknowledge support from the Centre National d’Etudes Spatiales (CNES).","doi":"10.1093/mnras/stae2053","language":[{"iso":"eng"}],"isi":1,"intvolume":" 534","ddc":["520"]},{"file_date_updated":"2025-01-01T23:30:03Z","type":"journal_article","publication_status":"published","dataavailabilitystatement":"Structures of the three SCs were deposited in PDB (accessions 8PW5, 8PW6 and 8PW7) with corresponding cryo-EM density maps in EMDB (IDs 17989, 17990 and 17991). As the models were built on composite maps, the consensus and focused maps for all components of the three SCs have also been deposited on EMDB (18023, 18022, 18025, 18024, 18027, 18026, 18017, 18018, 18019, 18021, 18020, 18015, 18011, 18012, 18013 and 18014). Similarly, structures of complex I were deposited in PDB (accessions 8RGR, 8RGQ, 8RGP and 8RGT) with corresponding composite cryo-EM density maps (19147, 19146, 19145 and 19148) and consensus/focused maps (19085, 19086, 19087, 19091, 19092, 19093, 19088, 19089, 19090, 19105, 19106 and 19107) in EMDB. The following previously deposited models (PDB codes) have been used in the manuscript: 5gup, 5xth, 5iy5, 1ooc, 5z62, 3cx5, 7o3c, 5j4z, 5j7y, 7o37 and 6g2j. Uncropped gels and western blot, as well as the raw data for the activity assays summarized in Extended Data Fig. 8h, have been provided as Source data in this publication. Source data are provided with this paper.","status":"public","date_published":"2024-07-01T00:00:00Z","project":[{"grant_number":"101020697","_id":"627abdeb-2b32-11ec-9570-ec31a97243d3","name":"Structure and mechanism of respiratory chain molecular machines","call_identifier":"H2020"}],"abstract":[{"text":"Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their role in mammalian metabolism has been hotly debated. Although recent studies have shown that different tissues/organs are equipped with specific sets of supercomplexes, depending on their metabolic needs, the notion that supercomplexes have a role in the regulation of metabolism has been challenged. However, irrespective of the mechanistic conclusions, the composition of various high molecular weight supercomplexes remains uncertain. Here, using cryogenic electron microscopy, we demonstrate that mammalian (mouse) tissues contain three defined types of ‘respirasome’, supercomplexes made of CI, CIII2 and CIV. The stoichiometry and position of CIV differs in the three respirasomes, of which only one contains the supercomplex-associated factor SCAF1, whose involvement in respirasome formation has long been contended. Our structures confirm that the ‘canonical’ respirasome (the C-respirasome, CICIII2CIV) does not contain SCAF1, which is instead associated to a different respirasome (the CS-respirasome), containing a second copy of CIV. We also identify an alternative respirasome (A-respirasome), with CIV bound to the ‘back’ of CI, instead of the ‘toe’. This structural characterization of mouse mitochondrial supercomplexes allows us to hypothesize a mechanistic basis for their specific role in different metabolic conditions.","lang":"eng"}],"year":"2024","article_processing_charge":"No","publisher":"Springer Nature","month":"07","ec_funded":1,"corr_author":"1","fulldoi":"https://doi.org/10.1038/s41594-024-01255-0","article_type":"original","related_material":{"link":[{"url":"https://doi.org/10.1038/s41594-025-01721-3","relation":"erratum"}]},"researchdata_availability":"yes","department":[{"_id":"LeSa"}],"author":[{"full_name":"Vercellino, Irene","last_name":"Vercellino","orcid":"0000-0001-5618-3449","first_name":"Irene","id":"3ED6AF16-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Sazanov","full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"}],"publication_identifier":{"eissn":["1545-9985"],"issn":["1545-9993"]},"supplementarymaterial":"yes","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa_version":"Submitted Version","has_accepted_license":"1","day":"01","das_tickbox":"1","language":[{"iso":"eng"}],"doi":"10.1038/s41594-024-01255-0","ddc":["572"],"intvolume":" 31","isi":1,"pmid":1,"external_id":{"isi":["001196897300001"],"pmid":["38575788"]},"date_created":"2024-04-14T22:01:03Z","acknowledgement":"Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their role in mammalian metabolism has been hotly debated. Although recent studies have shown that different tissues/organs are equipped with specific sets of supercomplexes, depending on their metabolic needs, the notion that supercomplexes have a role in the regulation of metabolism has been challenged. However, irrespective of the mechanistic conclusions, the composition of various high molecular weight supercomplexes remains uncertain. Here, using cryogenic electron microscopy, we demonstrate that mammalian (mouse) tissues contain three defined types of ‘respirasome’, supercomplexes made of CI, CIII2 and CIV. The stoichiometry and position of CIV differs in the three respirasomes, of which only one contains the supercomplex-associated factor SCAF1, whose involvement in respirasome formation has long been contended. Our structures confirm that the ‘canonical’ respirasome (the C-respirasome, CICIII2CIV) does not contain SCAF1, which is instead associated to a different respirasome (the CS-respirasome), containing a second copy of CIV. We also identify an alternative respirasome (A-respirasome), with CIV bound to the ‘back’ of CI, instead of the ‘toe’. This structural characterization of mouse mitochondrial supercomplexes allows us to hypothesize a mechanistic basis for their specific role in different metabolic conditions.","quality_controlled":"1","volume":31,"_id":"15323","page":"1061-1071","publication":"Nature Structural and Molecular Biology","file":[{"checksum":"21f05d188762acd7f49a97f3d09c8d9f","embargo":"2025-01-01","creator":"lsazanov","relation":"main_file","file_name":"megacomplex_submit_NSMB_withFigures.pdf","content_type":"application/pdf","file_id":"15392","file_size":24424729,"date_updated":"2025-01-01T23:30:03Z","access_level":"open_access","date_created":"2024-05-14T11:57:56Z"}],"citation":{"chicago":"Vercellino, Irene, and Leonid A Sazanov. “SCAF1 Drives the Compositional Diversity of Mammalian Respirasomes.” Nature Structural and Molecular Biology. Springer Nature, 2024. https://doi.org/10.1038/s41594-024-01255-0.","ama":"Vercellino I, Sazanov LA. SCAF1 drives the compositional diversity of mammalian respirasomes. Nature Structural and Molecular Biology. 2024;31:1061-1071. doi:10.1038/s41594-024-01255-0","apa":"Vercellino, I., & Sazanov, L. A. (2024). SCAF1 drives the compositional diversity of mammalian respirasomes. Nature Structural and Molecular Biology. Springer Nature. https://doi.org/10.1038/s41594-024-01255-0","ista":"Vercellino I, Sazanov LA. 2024. SCAF1 drives the compositional diversity of mammalian respirasomes. Nature Structural and Molecular Biology. 31, 1061–1071.","short":"I. Vercellino, L.A. Sazanov, Nature Structural and Molecular Biology 31 (2024) 1061–1071.","mla":"Vercellino, Irene, and Leonid A. Sazanov. “SCAF1 Drives the Compositional Diversity of Mammalian Respirasomes.” Nature Structural and Molecular Biology, vol. 31, Springer Nature, 2024, pp. 1061–71, doi:10.1038/s41594-024-01255-0.","ieee":"I. Vercellino and L. A. Sazanov, “SCAF1 drives the compositional diversity of mammalian respirasomes,” Nature Structural and Molecular Biology, vol. 31. Springer Nature, pp. 1061–1071, 2024."},"title":"SCAF1 drives the compositional diversity of mammalian respirasomes","oa":1,"scopus_import":"1","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"LifeSc"},{"_id":"PreCl"},{"_id":"ScienComp"}],"date_updated":"2026-10-16T08:43:37Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"publication_identifier":{"issn":["1552-5260"],"eissn":["1552-5279"]},"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"supplementarymaterial":"no","has_accepted_license":"1","day":"01","das_tickbox":"0","OA_place":"publisher","fulldoi":"https://doi.org/10.1002/alz.085971","author":[{"full_name":"Petrova, Olga","last_name":"Petrova","id":"5D8C9660-5D49-11EA-8188-567B3DDC885E","first_name":"Olga"},{"full_name":"Trushin, Sergey A","last_name":"Trushin","first_name":"Sergey A"},{"first_name":"Thi Kim Oanh","last_name":"Nguyen","full_name":"Nguyen, Thi Kim Oanh"},{"full_name":"Ostroot, Mark","last_name":"Ostroot","first_name":"Mark"},{"last_name":"Schellenberg","full_name":"Schellenberg, Matthew","first_name":"Matthew"},{"last_name":"Johnson","full_name":"Johnson, Graham","first_name":"Graham"},{"last_name":"Trushina","full_name":"Trushina, Eugenia","first_name":"Eugenia"},{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989","first_name":"Leonid A","last_name":"Sazanov","full_name":"Sazanov, Leonid A"}],"department":[{"_id":"LeSa"}],"researchdata_availability":"no","abstract":[{"lang":"eng","text":"Background: We identified small molecule tricyclic pyrone compound CP2 as a mild mitochondrial complex I (MCI) inhibitor that induces neuroprotection in multiple mouse models of AD. One of the major concerns while targeting mitochondria is the production of reactive oxygen species (ROS). CP2 consists of two diastereoisomers, D1 and D2, with distinct activity and toxicity profiles. This study was designed to understand how structure of D1 and D2 affects their binding to MCI and the consequential impact on ROS production.\r\n\r\nMethod: The X-ray crystallography and cryo-electron microscopy (cryo-EM) at global resolution of 3.25-3.27Å were employed to identify the molecular structure of D1 and D2 and the D1 binding to the isolated ovine MCI. The assessment of the MCI inhibition and the extent of ROS generation were done in isolated MCI and human neuroblastoma MC65 cells using flow cytometry, a Seahorse extracellular flux analyzer, and the kinetic studies.\r\n\r\nResult: In the closed conformation of MCI, D1 selectively binds to the deep Quinone-site (Qd) but not to the shallow Q-site (Qs), sharing the same binding pocket as rotenone. In the open MCI state, D1 exclusively binds to the Qs in contrast to rotenone, which binds Qd and Qs in both closed and open states. At the same concentrations, D1 inhibits respiration to a greater extent compared to D2 (5:1 ratio) and produces higher level of ROS.\r\n\r\nConclusion:Cryo-EM unambiguously identified binding of D1 to both the Qd and Qs sites, contingent upon the conformational state of MCI. In contrast to rotenone, D1 binds Qd only in the closed conformation during catalytic cycle, leading to mild inhibition. Superimposing X-ray crystallography data of D1 and D2 onto cryo-EM data suggests that the orientation of the methyl group in D2 induces a flatter conformation, resulting in lower binding affinity to MCI, which correlates with lower inhibition and toxicity compared to D1. At physiologically relevant concentrations, CP2 (D1:D2 = 1:1) demonstrates low MCI inhibition yielding negligible ROS levels. This observation provides new insight into the absence of toxicity associated with CP2 treatment in vivo, further highlighting feasibility for the development of safe and efficacious MCI inhibitors."}],"publisher":"Wiley","year":"2024","article_processing_charge":"Yes (in subscription journal)","month":"12","file_date_updated":"2025-01-29T15:24:50Z","type":"other_academic_publication","publication_status":"published","date_published":"2024-12-01T00:00:00Z","status":"public","OA_type":"hybrid","title":"Structure‐activity relationship study of neuroprotective complex I inhibitor CP2","oa":1,"date_updated":"2026-10-16T08:42:53Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","volume":20,"_id":"18967","publication":"Alzheimer's & Dementia","file":[{"checksum":"e914bd5f3a701659ab79d497a122811f","creator":"dernst","success":1,"file_id":"18968","file_size":70870,"relation":"main_file","content_type":"application/pdf","file_name":"2024_AlzheimerDementia_Petrova.pdf","date_updated":"2025-01-29T15:24:50Z","date_created":"2025-01-29T15:24:50Z","access_level":"open_access"}],"citation":{"chicago":"Petrova, Olga, Sergey A Trushin, Thi Kim Oanh Nguyen, Mark Ostroot, Matthew Schellenberg, Graham Johnson, Eugenia Trushina, and Leonid A Sazanov. Structure‐activity Relationship Study of Neuroprotective Complex I Inhibitor CP2. Alzheimer’s & Dementia. Vol. 20. Wiley, 2024. https://doi.org/10.1002/alz.085971.","ama":"Petrova O, Trushin SA, Nguyen TKO, et al. Structure‐activity Relationship Study of Neuroprotective Complex I Inhibitor CP2. Vol 20. Wiley; 2024. doi:10.1002/alz.085971","apa":"Petrova, O., Trushin, S. A., Nguyen, T. K. O., Ostroot, M., Schellenberg, M., Johnson, G., … Sazanov, L. A. (2024). Structure‐activity relationship study of neuroprotective complex I inhibitor CP2. Alzheimer’s & Dementia (Vol. 20). Wiley. https://doi.org/10.1002/alz.085971","ista":"Petrova O, Trushin SA, Nguyen TKO, Ostroot M, Schellenberg M, Johnson G, Trushina E, Sazanov LA. 2024. Structure‐activity relationship study of neuroprotective complex I inhibitor CP2, Wiley,p.","short":"O. Petrova, S.A. Trushin, T.K.O. Nguyen, M. Ostroot, M. Schellenberg, G. Johnson, E. Trushina, L.A. Sazanov, Structure‐activity Relationship Study of Neuroprotective Complex I Inhibitor CP2, Wiley, 2024.","mla":"Petrova, Olga, et al. “Structure‐activity Relationship Study of Neuroprotective Complex I Inhibitor CP2.” Alzheimer’s & Dementia, vol. 20, no. S6, e085971, Wiley, 2024, doi:10.1002/alz.085971.","ieee":"O. Petrova et al., Structure‐activity relationship study of neuroprotective complex I inhibitor CP2, vol. 20, no. S6. Wiley, 2024."},"article_number":"e085971","issue":"S6","date_created":"2025-01-29T15:21:40Z","quality_controlled":"1","language":[{"iso":"eng"}],"doi":"10.1002/alz.085971","ddc":["570"],"intvolume":" 20"},{"_id":"18581","volume":15,"publication":"Stem Cell Research and Therapy","citation":{"apa":"Marolt Presen, D., Goeschl, V., Hanetseder, D., Ogrin, L., Stetco, A. L., Tansek, A., … Redl, H. (2024). Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. Stem Cell Research and Therapy. Springer Nature. https://doi.org/10.1186/s13287-024-03960-5","ama":"Marolt Presen D, Goeschl V, Hanetseder D, et al. Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. Stem Cell Research and Therapy. 2024;15. doi:10.1186/s13287-024-03960-5","chicago":"Marolt Presen, Darja, Vanessa Goeschl, Dominik Hanetseder, Laura Ogrin, Alexandra Larissa Stetco, Anja Tansek, Laura Pozenel, et al. “Prolonged Cultivation Enhances the Stimulatory Activity of HiPSC Mesenchymal Progenitor-Derived Conditioned Medium.” Stem Cell Research and Therapy. Springer Nature, 2024. https://doi.org/10.1186/s13287-024-03960-5.","ieee":"D. Marolt Presen et al., “Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium,” Stem Cell Research and Therapy, vol. 15. Springer Nature, 2024.","mla":"Marolt Presen, Darja, et al. “Prolonged Cultivation Enhances the Stimulatory Activity of HiPSC Mesenchymal Progenitor-Derived Conditioned Medium.” Stem Cell Research and Therapy, vol. 15, 434, Springer Nature, 2024, doi:10.1186/s13287-024-03960-5.","short":"D. Marolt Presen, V. Goeschl, D. Hanetseder, L. Ogrin, A.L. Stetco, A. Tansek, L. Pozenel, B. Bruszel, G. Mitulovic, J. Oesterreicher, J. Zipperle, B. Schaedl, W. Holnthoner, J. Grillari, H. Redl, Stem Cell Research and Therapy 15 (2024).","ista":"Marolt Presen D, Goeschl V, Hanetseder D, Ogrin L, Stetco AL, Tansek A, Pozenel L, Bruszel B, Mitulovic G, Oesterreicher J, Zipperle J, Schaedl B, Holnthoner W, Grillari J, Redl H. 2024. Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. Stem Cell Research and Therapy. 15, 434."},"file":[{"success":1,"creator":"dernst","checksum":"91edba8edde30d781dce89fdd5cadc39","access_level":"open_access","date_created":"2024-12-10T08:28:17Z","date_updated":"2024-12-10T08:28:17Z","relation":"main_file","file_name":"2024_StemCellResearch_Presen.pdf","content_type":"application/pdf","file_size":6690494,"file_id":"18641"}],"title":"Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium","oa":1,"OA_type":"gold","DOAJ_listed":"1","scopus_import":"1","date_updated":"2026-10-16T08:56:29Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","language":[{"iso":"eng"}],"doi":"10.1186/s13287-024-03960-5","ddc":["570"],"intvolume":" 15","isi":1,"pmid":1,"external_id":{"pmid":["39551765"],"isi":["001356479400001"]},"article_number":"434","acknowledgement":"We thank the personnel of the Lorenz-Böhler-Unfallkrankenhaus for providing the human tissue waste for primary cell isolation and the New York Stem Cell Foundation Research Institute for providing the human induced pluripotent stem cell line 1013 A and its mesenchymal progenitors. We also thank all our colleagues at the Ludwig Boltzmann Institute for Traumatology for their suggestions and ongoing support of the project. InstaText writing tool (https://instatext.io) was used to edit the English language of the final manuscript.\r\nThis work has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie actions (grant agreement No. 657716) and the Transforming European Industry call H2020-NMBP-TRIND-2020 (grant agreement No. 953134), as well as by the FFG Industrienahe Dissertation program (grant agreement No. 867803 and 853056), the FEMtech Praktika program (grant agreement No. 852154, 868917 and 877951) and the Production of the Future program (grant agreement No. 877452).","date_created":"2024-11-24T23:01:47Z","quality_controlled":"1","OA_place":"publisher","fulldoi":"https://doi.org/10.1186/s13287-024-03960-5","article_type":"original","researchdata_availability":"yes","department":[{"_id":"LifeSc"}],"author":[{"last_name":"Marolt Presen","full_name":"Marolt Presen, Darja","first_name":"Darja"},{"first_name":"Vanessa","full_name":"Goeschl, Vanessa","last_name":"Goeschl"},{"first_name":"Dominik","last_name":"Hanetseder","full_name":"Hanetseder, Dominik"},{"last_name":"Ogrin","full_name":"Ogrin, Laura","first_name":"Laura"},{"first_name":"Alexandra Larissa","last_name":"Stetco","full_name":"Stetco, Alexandra Larissa"},{"last_name":"Tansek","full_name":"Tansek, Anja","first_name":"Anja"},{"last_name":"Pozenel","full_name":"Pozenel, Laura","first_name":"Laura"},{"id":"70abbbb3-88ea-11ec-8e0a-e8c939944834","first_name":"Bella","full_name":"Bruszel, Bella","last_name":"Bruszel"},{"full_name":"Mitulovic, Goran","last_name":"Mitulovic","first_name":"Goran"},{"full_name":"Oesterreicher, Johannes","last_name":"Oesterreicher","first_name":"Johannes"},{"last_name":"Zipperle","full_name":"Zipperle, Johannes","first_name":"Johannes"},{"full_name":"Schaedl, Barbara","last_name":"Schaedl","first_name":"Barbara"},{"full_name":"Holnthoner, Wolfgang","last_name":"Holnthoner","first_name":"Wolfgang"},{"last_name":"Grillari","full_name":"Grillari, Johannes","first_name":"Johannes"},{"first_name":"Heinz","full_name":"Redl, Heinz","last_name":"Redl"}],"publication_identifier":{"eissn":["1757-6512"]},"supplementarymaterial":"yes","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"oa_version":"Published Version","day":"01","has_accepted_license":"1","das_tickbox":"1","file_date_updated":"2024-12-10T08:28:17Z","type":"journal_article","publication_status":"published","dataavailabilitystatement":"All data generated and analysed during this study are included in this published article and its supplementary information files. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD052766 (access details are provided in Suppl. Data File 1). The raw datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.","status":"public","date_published":"2024-12-01T00:00:00Z","abstract":[{"text":"Background: Human induced pluripotent stem cells represent a scalable source of youthful tissue progenitors and secretomes for regenerative therapies. The aim of our study was to investigate the potential of conditioned medium (CM) from hiPSC-mesenchymal progenitors (hiPSC-MPs) to stimulate osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells (MSCs). We also investigated whether prolonged cultivation or osteogenic pre-differentiation of hiPSC-MPs could enhance the stimulatory activity of CM.\r\nMethods: MSCs were isolated from 13 donors (age 20–90 years). CM derived from hiPSC-MPs was added to the MSC cultures and the effects on proliferation and osteogenic differentiation were examined after 14 days and 6 weeks. The stimulatory activity of hiPSC-MP-CM was compared with the activity of MSC-derived CM and with the activity of CM prepared from hiPSC-MPs pre-cultured in growth or osteogenic medium for 14 days. Comparative proteomic analysis of CM was performed to gain insight into the molecular components responsible for the stimulatory activity.\r\nResults: Primary bone marrow-derived MSC exhibited variability, with a tendency towards lower proliferation and tri-lineage differentiation in older donors. hiPSC-MP-CM increased the proliferation and alkaline phosphatase activity of MSC from several adult/aged donors after 14 days of continuous supplementation under osteogenic conditions. However, CM supplementation failed to improve the mineralization of MSC pellets after 6 weeks under osteogenic conditions. hiPSC-MP-CM showed greater enhancement of proliferation and ALP activity than CM derived from bone marrow-derived MSCs. Moreover, 14-day cultivation but not osteogenic pre-differentiation of hiPSC-MPs strongly enhanced CM stimulatory activity. Quantitative proteomic analysis of d14-CM revealed a distinct profile of components that formed a highly interconnected associations network with two clusters, one functionally associated with binding and organization of actin/cytoskeletal components and the other with structural constituents of the extracellular matrix, collagen, and growth factor binding. Several hub proteins were identified that were reported to have functions in cell-extracellular matrix interaction, osteogenic differentiation and development.\r\nConclusions: Our data show that hiPSC-MP-CM enhances early osteogenic differentiation of human bone marrow-derived MSCs and that prolonged cultivation of hiPSC-MPs enhances CM-stimulatory activity. Proteomic analysis of the upregulated protein components provides the basis for further optimization of hiPSC-MP-CM for bone regenerative therapies.","lang":"eng"}],"year":"2024","article_processing_charge":"Yes","publisher":"Springer Nature","month":"12"},{"author":[{"last_name":"Breton","full_name":"Breton, S. N.","first_name":"S. N."},{"first_name":"A. F.","last_name":"Lanza","full_name":"Lanza, A. F."},{"last_name":"Messina","full_name":"Messina, S.","first_name":"S."},{"first_name":"I.","last_name":"Pagano","full_name":"Pagano, I."},{"full_name":"Bugnet, Lisa Annabelle","last_name":"Bugnet","orcid":"0000-0003-0142-4000","first_name":"Lisa Annabelle","id":"d9edb345-f866-11ec-9b37-d119b5234501"},{"full_name":"Corsaro, E.","last_name":"Corsaro","first_name":"E."},{"first_name":"R. A.","full_name":"García, R. A.","last_name":"García"},{"full_name":"Mathur, S.","last_name":"Mathur","first_name":"S."},{"last_name":"Santos","full_name":"Santos, A. R. G.","first_name":"A. R. G."},{"full_name":"Aigrain, S.","last_name":"Aigrain","first_name":"S."},{"first_name":"L.","last_name":"Amard","full_name":"Amard, L."},{"first_name":"A. S.","full_name":"Brun, A. S.","last_name":"Brun"},{"first_name":"L.","last_name":"Degott","full_name":"Degott, L."},{"last_name":"Noraz","full_name":"Noraz, Q.","first_name":"Q."},{"first_name":"D. B.","full_name":"Palakkatharappil, D. B.","last_name":"Palakkatharappil"},{"last_name":"Panetier","full_name":"Panetier, E.","first_name":"E."},{"last_name":"Strugarek","full_name":"Strugarek, A.","first_name":"A."},{"full_name":"Belkacem, K.","last_name":"Belkacem","first_name":"K."},{"last_name":"Goupil","full_name":"Goupil, M.-J","first_name":"M.-J"},{"first_name":"R. M.","full_name":"Ouazzani, R. M.","last_name":"Ouazzani"},{"last_name":"Philidet","full_name":"Philidet, J.","first_name":"J."},{"first_name":"C.","full_name":"Renié, C.","last_name":"Renié"},{"first_name":"O.","last_name":"Roth","full_name":"Roth, O."}],"department":[{"_id":"LiBu"}],"researchdata_availability":"yes","article_type":"original","fulldoi":"https://doi.org/10.1051/0004-6361/202449893","OA_place":"publisher","das_tickbox":"0","has_accepted_license":"1","day":"01","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"supplementarymaterial":"yes","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"status":"public","date_published":"2024-09-01T00:00:00Z","publication_status":"published","type":"journal_article","file_date_updated":"2025-01-27T13:18:41Z","month":"09","publisher":"EDP Sciences","year":"2024","article_processing_charge":"No","abstract":[{"lang":"eng","text":"The Planetary Transits and Oscillations of stars mission (PLATO) will allow us to measure surface rotation and monitor photometric activity of tens of thousands of main sequence solar-type and subgiant stars. This paper is the first of a series dedicated to the preparation of the analysis of stellar surface rotation and photospheric activity with the near-future PLATO data. We describe in this work the strategy that will be implemented in the PLATO pipeline to measure stellar surface rotation, photometric activity, and long-term modulations. The algorithms are applied on both noise-free and noisy simulations of solar-type stars, which include activity cycles, latitudinal differential rotation, and spot evolution. PLATO simulated systematics are included in the noisy light curves. We show that surface rotation periods can be recovered with confidence for most of the stars with only six months of observations and that the recovery rate of the analysis significantly improves as additional observations are collected. This means that the first PLATO data release will already provide a substantial set of measurements for this quantity, with a significant refinement on their quality as the instrument obtains longer light curves. Measuring the Schwabe-like magnetic activity cycle during the mission will require that the same field be observed over a significant timescale (more than four years). Nevertheless, PLATO will provide a vast and robust sample of solar-type stars with constraints on the activity-cycle length. Such a sample is lacking from previous missions dedicated to space photometry."}],"arxiv":1,"file":[{"date_created":"2025-01-27T13:18:41Z","access_level":"open_access","file_size":6212007,"file_id":"18905","file_name":"2024_AstronomyAstrophysics_Breton.pdf","content_type":"application/pdf","relation":"main_file","date_updated":"2025-01-27T13:18:41Z","success":1,"checksum":"5c871ba7370a507ed6ea9fb2304d8263","creator":"dernst"}],"citation":{"ieee":"S. N. Breton et al., “Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves,” Astronomy & Astrophysics, vol. 689. EDP Sciences, 2024.","mla":"Breton, S. N., et al. “Measuring Stellar Surface Rotation and Activity with the PLATO Mission. I. Strategy and Application to Simulated Light Curves.” Astronomy & Astrophysics, vol. 689, A229, EDP Sciences, 2024, doi:10.1051/0004-6361/202449893.","ista":"Breton SN, Lanza AF, Messina S, Pagano I, Bugnet LA, Corsaro E, García RA, Mathur S, Santos ARG, Aigrain S, Amard L, Brun AS, Degott L, Noraz Q, Palakkatharappil DB, Panetier E, Strugarek A, Belkacem K, Goupil M-J, Ouazzani RM, Philidet J, Renié C, Roth O. 2024. Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves. Astronomy & Astrophysics. 689, A229.","short":"S.N. Breton, A.F. Lanza, S. Messina, I. Pagano, L.A. Bugnet, E. Corsaro, R.A. García, S. Mathur, A.R.G. Santos, S. Aigrain, L. Amard, A.S. Brun, L. Degott, Q. Noraz, D.B. Palakkatharappil, E. Panetier, A. Strugarek, K. Belkacem, M.-J. Goupil, R.M. Ouazzani, J. Philidet, C. Renié, O. Roth, Astronomy & Astrophysics 689 (2024).","apa":"Breton, S. N., Lanza, A. F., Messina, S., Pagano, I., Bugnet, L. A., Corsaro, E., … Roth, O. (2024). Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202449893","chicago":"Breton, S. N., A. F. Lanza, S. Messina, I. Pagano, Lisa Annabelle Bugnet, E. Corsaro, R. A. García, et al. “Measuring Stellar Surface Rotation and Activity with the PLATO Mission. I. Strategy and Application to Simulated Light Curves.” Astronomy & Astrophysics. EDP Sciences, 2024. https://doi.org/10.1051/0004-6361/202449893.","ama":"Breton SN, Lanza AF, Messina S, et al. Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves. Astronomy & Astrophysics. 2024;689. doi:10.1051/0004-6361/202449893"},"publication":"Astronomy & Astrophysics","_id":"18904","volume":689,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2026-10-16T08:55:46Z","scopus_import":"1","OA_type":"hybrid","title":"Measuring stellar surface rotation and activity with the PLATO mission. I. Strategy and application to simulated light curves","oa":1,"isi":1,"intvolume":" 689","ddc":["520"],"doi":"10.1051/0004-6361/202449893","language":[{"iso":"eng"}],"quality_controlled":"1","acknowledgement":"This work presents results from the European Space Agency (ESA) space mission PLATO. The PLATO payload, the PLATO Ground Segment and PLATO data processing are joint developments of ESA and the PLATO Mission Consortium (PMC). Funding for the PMC is provided at national levels, in particular by countries participating in the PLATO Multilateral Agreement (Austria, Belgium, Czech Republic, Denmark, France, Germany, Italy, Netherlands, Portugal, Spain, Sweden, Switzerland, Norway, and United Kingdom) and institutions from Brazil. Members of the PLATO Consortium can be found at https://platomission.com. The ESA PLATO mission website is https://www.cosmos.esa.int/plato. The authors thank the teams working for PLATO for all their work. They acknowledge the critical reading and the constructive comments from the anonymous referee that significantly allowed improving the original version of this paper. They finally thank R. Samadi for helpful advice and suggestions concerning the PSLS abilities. S.N.B, A.F.L, S.Me, I.P and E.C acknowledge support from PLATO ASI-INAF agreement no. 2022-28-HH.0 “PLATO Fase D”. S.N.B, L.A, A.S.B, Q.N, and A.S acknowledge financial support by ERC Whole Sun Synergy grant #810218. S.N.B, R.A.G, L.A, A.S.B, Q.N., D.B.P, E.P, and A.S acknowledge the support from PLATO CNES grant. R.A.G, D.B.P, and E.P acknowledge the support from SoHO/GOLF CNES grant. A.S.B, Q.N, and A.S acknowledge the support from INSU/PNST grant and Solar Orbiter CNES grant. A.S acknowledges funding from from the European Union’s Horizon-2020 research and innovation program (grant agreement no. 776403 ExoplANETS-A) and the Programme National de Planétologie (PNP). A.R.G.S acknowledges the support from the FCT through national funds and FEDER through COMPETE2020 (UIDB/04434/2020, UIDP/04434/2020, 2022.03993.PTDC) and the support from the FCT through the work contract No. 2020.02480.CEECIND/CP1631/CT0001. S.Ma acknowledges support from the Spanish Ministry of Science and Innovation (MICINN) with the Ramón y Cajal fellowship no. RYC-2015-17697 and through AEI under the Severo Ochoa Centres of Excellence Programme 2020–2023 (CEX2019-000920-S). S.Ma acknowledges support from the Spanish Ministry of Science and Innovation (MICINN) with the grant no. PID2019-107187GB-I00. M.J.G., K.B., R.M.O, J.P, O.R., C.R. acknowledge support from CNES. The computations were performed with the IRFU/CEA Saclay server facilities, funded by ERC Synergy grant WholeSun No.810218, the P2IO Labex emergence project FlarePredict, and CNES PLATO funds. Software:star-privateer (this work), pyspot (Aigrain et al. 2015), PSLS (Samadi et al. 2019), numpy (Harris et al. 2020), matplotlib (Hunter 2007), scipy (Virtanen et al. 2020), astropy (Astropy Collaboration 2022), pandas (Wes McKinney 2010; The pandas development team 2020), scikit-learn (Pedregosa et al. 2011).","date_created":"2025-01-27T13:12:44Z","article_number":"A229","external_id":{"arxiv":["2407.03709"],"isi":["001366206400007"]}}]