[{"conference":{"end_date":"2025-04-18","location":"Miyakojima, Japan","start_date":"2025-04-14","name":"FC: Financial Cryptography and Data Security"},"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2502.10074","open_access":"1"}],"type":"conference","oa":1,"doi":"10.1007/978-3-032-07024-1_18","acknowledgement":"This work was supported by the Austrian Science Fund (FWF) SFB project SpyCoDe F8502 and the Vienna Science and Technology Fund (WWTF) project SCALE2 CT22-045.","corr_author":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","alternative_title":["LNCS"],"department":[{"_id":"KrPi"}],"citation":{"ama":"Neiheiser R, Kokoris Kogias E. Anthemius: Efficient and modular block assembly for concurrent execution. In: <i>29th International Conference on Financial Cryptography and Data Security</i>. Vol 15751. Springer Nature; 2026:307-323. doi:<a href=\"https://doi.org/10.1007/978-3-032-07024-1_18\">10.1007/978-3-032-07024-1_18</a>","short":"R. Neiheiser, E. Kokoris Kogias, in:, 29th International Conference on Financial Cryptography and Data Security, Springer Nature, 2026, pp. 307–323.","mla":"Neiheiser, Ray, and Eleftherios Kokoris Kogias. “Anthemius: Efficient and Modular Block Assembly for Concurrent Execution.” <i>29th International Conference on Financial Cryptography and Data Security</i>, vol. 15751, Springer Nature, 2026, pp. 307–23, doi:<a href=\"https://doi.org/10.1007/978-3-032-07024-1_18\">10.1007/978-3-032-07024-1_18</a>.","ista":"Neiheiser R, Kokoris Kogias E. 2026. Anthemius: Efficient and modular block assembly for concurrent execution. 29th International Conference on Financial Cryptography and Data Security. FC: Financial Cryptography and Data Security, LNCS, vol. 15751, 307–323.","chicago":"Neiheiser, Ray, and Eleftherios Kokoris Kogias. “Anthemius: Efficient and Modular Block Assembly for Concurrent Execution.” In <i>29th International Conference on Financial Cryptography and Data Security</i>, 15751:307–23. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-3-032-07024-1_18\">https://doi.org/10.1007/978-3-032-07024-1_18</a>.","apa":"Neiheiser, R., &#38; Kokoris Kogias, E. (2026). Anthemius: Efficient and modular block assembly for concurrent execution. In <i>29th International Conference on Financial Cryptography and Data Security</i> (Vol. 15751, pp. 307–323). Miyakojima, Japan: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-032-07024-1_18\">https://doi.org/10.1007/978-3-032-07024-1_18</a>","ieee":"R. Neiheiser and E. Kokoris Kogias, “Anthemius: Efficient and modular block assembly for concurrent execution,” in <i>29th International Conference on Financial Cryptography and Data Security</i>, Miyakojima, Japan, 2026, vol. 15751, pp. 307–323."},"publisher":"Springer Nature","publication_identifier":{"eissn":["1611-3349"],"isbn":["9783032070234"],"issn":["0302-9743"]},"article_processing_charge":"No","day":"01","arxiv":1,"quality_controlled":"1","date_published":"2026-01-01T00:00:00Z","intvolume":"     15751","OA_place":"repository","abstract":[{"text":"Many blockchains such as Ethereum execute all incoming transactions sequentially significantly limiting the potential throughput. A common approach to scale execution is parallel execution engines that fully utilize modern multi-core architectures. Parallel execution is then either done optimistically, by executing transactions in parallel and detecting conflicts on the fly, or guided, by requiring exhaustive client transaction hints and scheduling transactions accordingly.\r\n\r\nHowever, recent studies have shown that the performance of parallel execution engines depends on the nature of the underlying workload. In fact, in some cases, only a 60% speed-up compared to sequential execution could be obtained. This is the case, as transactions that access the same resources must be executed sequentially. For example, if 10% of the transactions in a block access the same resource, the execution cannot meaningfully scale beyond 10 cores. Therefore, a single popular application can bottleneck the execution and limit the potential throughput.\r\n\r\nIn this paper, we introduce Anthemius, a block construction algorithm that optimizes parallel transaction execution throughput. We evaluate Anthemius exhaustively under a range of workloads, and show that Anthemius enables the underlying parallel execution engine to process over twice as many transactions.","lang":"eng"}],"page":"307-323","project":[{"grant_number":"F8502","name":"Interface Theory for Security and Privacy","_id":"34a1b658-11ca-11ed-8bc3-c75229f0241e"},{"_id":"7bdd2f70-9f16-11ee-852c-b7950bc6d277","name":"SeCure, privAte, and interoperabLe layEr 2","grant_number":"ICT22-045"}],"volume":15751,"year":"2026","external_id":{"arxiv":["2502.10074"]},"date_created":"2026-01-25T23:01:40Z","oa_version":"Preprint","_id":"21042","publication":"29th International Conference on Financial Cryptography and Data Security","language":[{"iso":"eng"}],"title":"Anthemius: Efficient and modular block assembly for concurrent execution","scopus_import":"1","status":"public","OA_type":"green","date_updated":"2026-02-12T13:39:07Z","publication_status":"published","author":[{"last_name":"Neiheiser","id":"f09651b9-fec0-11ec-b5d8-934aff0e52a4","orcid":"0000-0001-7227-8309","first_name":"Ray","full_name":"Neiheiser, Ray"},{"last_name":"Kokoris Kogias","id":"f5983044-d7ef-11ea-ac6d-fd1430a26d30","full_name":"Kokoris Kogias, Eleftherios","orcid":"0000-0002-8827-3382","first_name":"Eleftherios"}],"month":"01"},{"publication_status":"published","date_updated":"2026-02-16T07:56:09Z","OA_type":"green","month":"01","author":[{"first_name":"Quentin","full_name":"Kniep, Quentin","last_name":"Kniep"},{"full_name":"Kokoris Kogias, Eleftherios","orcid":"0000-0002-8827-3382","first_name":"Eleftherios","last_name":"Kokoris Kogias","id":"f5983044-d7ef-11ea-ac6d-fd1430a26d30"},{"last_name":"Sonnino","first_name":"Alberto","full_name":"Sonnino, Alberto"},{"full_name":"Zablotchi, Igor","first_name":"Igor","last_name":"Zablotchi"},{"last_name":"Zhang","first_name":"Nuda","full_name":"Zhang, Nuda"}],"publication":"29th International Conference on Financial Cryptography and Data Security","language":[{"iso":"eng"}],"_id":"21044","scopus_import":"1","status":"public","title":"Pilotfish: Distributed execution for scalable blockchains","date_created":"2026-01-25T23:01:41Z","external_id":{"arxiv":["2401.16292"]},"oa_version":"Preprint","page":"287-306","abstract":[{"text":"Scalability is a crucial requirement for modern large-scale systems, enabling elasticity and ensuring responsiveness under varying load. While cloud systems have achieved scalable architectures, blockchain systems remain constrained by the need to over-provision validator machines to handle peak load. This leads to resource inefficiency, poor cost scaling, and limits on performance. To address these challenges, we introduce Pilotfish, the first scale-out transaction execution engine for blockchains. Pilotfish enables validators to scale horizontally by distributing transaction execution across multiple worker machines, allowing elasticity without compromising consistency or determinism. It integrates seamlessly with the lazy blockchain architecture, completing the missing piece of execution elasticity. To achieve this, Pilotfish tackles several key challenges: ensuring scalable and strongly consistent distributed transactions, handling partial crash recovery with lightweight replication, and maintaining concurrency with a novel versioned-queue scheduling algorithm. Our evaluation shows that Pilotfish scales linearly up to at least eight workers per validator for compute-bound workloads, while maintaining low latency. By solving scalable execution, Pilotfish brings blockchains closer to achieving end-to-end elasticity, unlocking new possibilities for efficient and adaptable blockchain systems.","lang":"eng"}],"year":"2026","volume":15751,"quality_controlled":"1","day":"01","arxiv":1,"OA_place":"repository","intvolume":"     15751","date_published":"2026-01-01T00:00:00Z","publisher":"Springer Nature","alternative_title":["LNCS"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Kniep Q, Kokoris Kogias E, Sonnino A, Zablotchi I, Zhang N. Pilotfish: Distributed execution for scalable blockchains. In: <i>29th International Conference on Financial Cryptography and Data Security</i>. Vol 15751. Springer Nature; 2026:287-306. doi:<a href=\"https://doi.org/10.1007/978-3-032-07024-1_17\">10.1007/978-3-032-07024-1_17</a>","short":"Q. Kniep, E. Kokoris Kogias, A. Sonnino, I. Zablotchi, N. Zhang, in:, 29th International Conference on Financial Cryptography and Data Security, Springer Nature, 2026, pp. 287–306.","mla":"Kniep, Quentin, et al. “Pilotfish: Distributed Execution for Scalable Blockchains.” <i>29th International Conference on Financial Cryptography and Data Security</i>, vol. 15751, Springer Nature, 2026, pp. 287–306, doi:<a href=\"https://doi.org/10.1007/978-3-032-07024-1_17\">10.1007/978-3-032-07024-1_17</a>.","ista":"Kniep Q, Kokoris Kogias E, Sonnino A, Zablotchi I, Zhang N. 2026. Pilotfish: Distributed execution for scalable blockchains. 29th International Conference on Financial Cryptography and Data Security. FC: Financial Cryptography and Data Security, LNCS, vol. 15751, 287–306.","apa":"Kniep, Q., Kokoris Kogias, E., Sonnino, A., Zablotchi, I., &#38; Zhang, N. (2026). Pilotfish: Distributed execution for scalable blockchains. In <i>29th International Conference on Financial Cryptography and Data Security</i> (Vol. 15751, pp. 287–306). Miyakojima, Japan: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-032-07024-1_17\">https://doi.org/10.1007/978-3-032-07024-1_17</a>","chicago":"Kniep, Quentin, Eleftherios Kokoris Kogias, Alberto Sonnino, Igor Zablotchi, and Nuda Zhang. “Pilotfish: Distributed Execution for Scalable Blockchains.” In <i>29th International Conference on Financial Cryptography and Data Security</i>, 15751:287–306. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-3-032-07024-1_17\">https://doi.org/10.1007/978-3-032-07024-1_17</a>.","ieee":"Q. Kniep, E. Kokoris Kogias, A. Sonnino, I. Zablotchi, and N. Zhang, “Pilotfish: Distributed execution for scalable blockchains,” in <i>29th International Conference on Financial Cryptography and Data Security</i>, Miyakojima, Japan, 2026, vol. 15751, pp. 287–306."},"article_processing_charge":"No","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783032070234"]},"type":"conference","conference":{"end_date":"2025-04-18","location":"Miyakojima, Japan","start_date":"2025-04-14","name":"FC: Financial Cryptography and Data Security"},"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2401.16292","open_access":"1"}],"doi":"10.1007/978-3-032-07024-1_17","oa":1},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JoMa"},{"_id":"GradSch"}],"citation":{"ama":"Torralba Torregrosa A, Matthee JJ, Pezzulli G, et al. A weak Ly α halo for an extremely bright little red dot. Indications of enshrouded supermassive black hole growth. <i>Astronomy and Astrophysics</i>. 2026;705. doi:<a href=\"https://doi.org/10.1051/0004-6361/202555596\">10.1051/0004-6361/202555596</a>","short":"A. Torralba Torregrosa, J.J. Matthee, G. Pezzulli, T. Urrutia, M. Gronke, S. Mascia, F. D’Eugenio, C. Di Cesare, A.C. Eilers, J.E. Greene, E. Iani, Y. Ishikawa, R. Mackenzie, R.P. Naidu, B. Navarrete, G. Kotiwale, Astronomy and Astrophysics 705 (2026).","mla":"Torralba Torregrosa, Alberto, et al. “A Weak Ly α Halo for an Extremely Bright Little Red Dot. Indications of Enshrouded Supermassive Black Hole Growth.” <i>Astronomy and Astrophysics</i>, vol. 705, A147, EDP Sciences, 2026, doi:<a href=\"https://doi.org/10.1051/0004-6361/202555596\">10.1051/0004-6361/202555596</a>.","apa":"Torralba Torregrosa, A., Matthee, J. J., Pezzulli, G., Urrutia, T., Gronke, M., Mascia, S., … Kotiwale, G. (2026). A weak Ly α halo for an extremely bright little red dot. Indications of enshrouded supermassive black hole growth. <i>Astronomy and Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/202555596\">https://doi.org/10.1051/0004-6361/202555596</a>","chicago":"Torralba Torregrosa, Alberto, Jorryt J Matthee, Gabriele Pezzulli, Tanya Urrutia, Max Gronke, Sara Mascia, Francesco D’Eugenio, et al. “A Weak Ly α Halo for an Extremely Bright Little Red Dot. Indications of Enshrouded Supermassive Black Hole Growth.” <i>Astronomy and Astrophysics</i>. EDP Sciences, 2026. <a href=\"https://doi.org/10.1051/0004-6361/202555596\">https://doi.org/10.1051/0004-6361/202555596</a>.","ieee":"A. Torralba Torregrosa <i>et al.</i>, “A weak Ly α halo for an extremely bright little red dot. Indications of enshrouded supermassive black hole growth,” <i>Astronomy and Astrophysics</i>, vol. 705. EDP Sciences, 2026.","ista":"Torralba Torregrosa A, Matthee JJ, Pezzulli G, Urrutia T, Gronke M, Mascia S, D’Eugenio F, Di Cesare C, Eilers AC, Greene JE, Iani E, Ishikawa Y, Mackenzie R, Naidu RP, Navarrete B, Kotiwale G. 2026. A weak Ly α halo for an extremely bright little red dot. Indications of enshrouded supermassive black hole growth. Astronomy and Astrophysics. 705, A147."},"publisher":"EDP Sciences","publication_identifier":{"issn":["0004-6361"],"eissn":["1432-0746"]},"article_processing_charge":"No","day":"14","arxiv":1,"quality_controlled":"1","date_published":"2026-01-14T00:00:00Z","intvolume":"       705","OA_place":"publisher","file_date_updated":"2026-02-16T07:35:03Z","type":"journal_article","oa":1,"doi":"10.1051/0004-6361/202555596","has_accepted_license":"1","acknowledgement":"We thank the anonymous referee for constructive and useful comments. We thank Sebastiano Cantalupo for comments on the draft. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programme 114.27M6.001. Funded by the European Union (ERC, AGENTS, 101076224). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. We acknowledge funding from JWST program GO-3516. This work is based in part on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with program #3516. MG thanks the Max Planck Society for support through the MPRG. FDE acknowledges support by the Science and Technology Facilities Council (STFC), by the ERC through Advanced Grant 695671 “QUENCH”, and by the UKRI Frontier Research grant RISEandFALL. TU acknowledges funding from the ERC-AdG grant SPECMAP-CGM, GA 101020943. GK acknowledges support from the MERAC foundation.","article_number":"A147","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"corr_author":"1","_id":"21045","publication":"Astronomy and Astrophysics","language":[{"iso":"eng"}],"PlanS_conform":"1","article_type":"original","title":"A weak Ly α halo for an extremely bright little red dot. Indications of enshrouded supermassive black hole growth","scopus_import":"1","status":"public","file":[{"file_id":"21224","creator":"dernst","file_name":"2026_AstronomyAstrophysics_Torralba.pdf","relation":"main_file","access_level":"open_access","content_type":"application/pdf","checksum":"3782e03bc0843438aae8487f6af779c5","file_size":2259914,"date_updated":"2026-02-16T07:35:03Z","success":1,"date_created":"2026-02-16T07:35:03Z"}],"ddc":["520"],"OA_type":"diamond","date_updated":"2026-02-16T07:46:53Z","publication_status":"published","month":"01","author":[{"orcid":"0000-0001-5586-6950","first_name":"Alberto","full_name":"Torralba Torregrosa, Alberto","last_name":"Torralba Torregrosa","id":"018f0249-0e87-11f0-b167-cbce08fbd541"},{"last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720","full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","first_name":"Jorryt J"},{"first_name":"Gabriele","full_name":"Pezzulli, Gabriele","last_name":"Pezzulli"},{"full_name":"Urrutia, Tanya","first_name":"Tanya","last_name":"Urrutia"},{"first_name":"Max","full_name":"Gronke, Max","last_name":"Gronke"},{"first_name":"Sara","full_name":"Mascia, Sara","id":"edaf889c-c7cd-11ef-ab1b-bb28c431bd29","last_name":"Mascia"},{"first_name":"Francesco","full_name":"D’Eugenio, Francesco","last_name":"D’Eugenio"},{"full_name":"Di Cesare, Claudia","first_name":"Claudia","last_name":"Di Cesare","id":"2d002343-372f-11ef-98ec-a164d20427cb"},{"first_name":"Anna Christina","full_name":"Eilers, Anna Christina","last_name":"Eilers"},{"full_name":"Greene, Jenny E.","first_name":"Jenny E.","last_name":"Greene"},{"orcid":"0000-0001-8386-3546","first_name":"Edoardo","full_name":"Iani, Edoardo","last_name":"Iani","id":"4053390a-6b68-11ef-9828-a3b8adef8d0a"},{"last_name":"Ishikawa","first_name":"Yuzo","full_name":"Ishikawa, Yuzo"},{"full_name":"Mackenzie, Ruari","first_name":"Ruari","last_name":"Mackenzie"},{"full_name":"Naidu, Rohan P.","first_name":"Rohan P.","last_name":"Naidu"},{"last_name":"Navarrete","id":"aa14a535-50c9-11ef-b52e-e0c373d10148","first_name":"Benjamín","full_name":"Navarrete, Benjamín"},{"first_name":"Gauri","full_name":"Kotiwale, Gauri","id":"1438afc8-1ff6-11ee-9fa6-cd4a75d66875","last_name":"Kotiwale"}],"abstract":[{"lang":"eng","text":"The abundant population of little red dots (LRDs), compact objects with red UV to optical colors and broad Balmer lines at high redshift, is revealing new insights into the properties of early active galactic nuclei (AGN). Perhaps the most surprising features of this population are the presence of Balmer absorption and ubiquitous strong Balmer breaks. Recent models link these features to an active supermassive black hole (SMBH) cocooned in very dense gas (NH ∼ 1024 cm−2). We present a stringent test of such models using VLT/MUSE observations of A2744-45924, the most luminous LRD known to date (LHα ≈ 1044 erg s−1), located behind the Abell-2744 lensing cluster at z = 4.464 (μ = 1.8). We detect a moderately extended Lyα nebula (h ≈ 5.7 pkpc), spatially offset from the point-like Hα seen by JWST by ≈1.6 pkpc. The Lyα emission is narrow (FWHM = 270 ± 15 km s−1), and faint (Lyα = 0.07Hα) compared to Lyα nebulae typically observed around quasars of similar luminosity. We detect compact N IV]λ1486 emission, spatially aligned with Hα, and a spatial shift in the far-UV continuum matching the Lyα offset. We discuss that Hα and Lyα have distinct physical origins: Hα originates from the AGN, while Lyα is powered by star formation. In the environment of A2744-45924, we identified four extended Lyα halos (Δz < 0.02, Δr < 100 pkpc). Their Lyα luminosities match the expectations based on Hα emission, and show no evidence for radiation from A2744-45924 affecting its surroundings. The lack of strong, compact, and broad Lyα and the absence of a luminous extended halo, suggest that the UV AGN light is obscured by dense gas cloaking the SMBH with a covering factor close to unity."}],"volume":705,"project":[{"name":"Young galaxies as tracers and agents of cosmic reionization","_id":"bd9b2118-d553-11ed-ba76-db24564edfea","grant_number":"101076224"}],"year":"2026","external_id":{"arxiv":["2505.09542"]},"date_created":"2026-01-25T23:01:41Z","oa_version":"Published Version"},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2504.11203"}],"type":"book_chapter","oa":1,"doi":"10.1137/1.9781611978971.225","place":"Philadelphia, PA, United States","acknowledgement":"We thank the reviewers for both SODA and ATMCS for their comments, whichimproved the exposition. We thank Kate Turner for discussion and Clément Maria for pointing out thatAlexander’s theorem was already (well) known. Mathijs Wintraecken would like to express his gratitude tothe administrative support he received from University of Notre Dame during his visit and from Sophie Honnoratand Stephanie Verdonck at Inria in general.This work has been supported by the ANR grant StratMesh, ANR-24-CE48-1899, by NSF award 2444309, andthe welcome package from IDEX of the Université Côte d’Azur, ANR-15-IDEX-01.","citation":{"mla":"Chambers, Erin W., et al. “Braiding Vineyards.” <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, edited by Kasper Green Larsen and Barna Saha, Society for Industrial and Applied Mathematics, 2026, pp. 6240–63, doi:<a href=\"https://doi.org/10.1137/1.9781611978971.225\">10.1137/1.9781611978971.225</a>.","chicago":"Chambers, Erin W., Christopher D Fillmore, Elizabeth R Stephenson, and Mathijs Wintraecken. “Braiding Vineyards.” In <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, edited by Kasper Green Larsen and Barna Saha, 6240–63. Philadelphia, PA, United States: Society for Industrial and Applied Mathematics, 2026. <a href=\"https://doi.org/10.1137/1.9781611978971.225\">https://doi.org/10.1137/1.9781611978971.225</a>.","ieee":"E. W. Chambers, C. D. Fillmore, E. R. Stephenson, and M. Wintraecken, “Braiding Vineyards,” in <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, K. Green Larsen and B. Saha, Eds. Philadelphia, PA, United States: Society for Industrial and Applied Mathematics, 2026, pp. 6240–6263.","apa":"Chambers, E. W., Fillmore, C. D., Stephenson, E. R., &#38; Wintraecken, M. (2026). Braiding Vineyards. In K. Green Larsen &#38; B. Saha (Eds.), <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i> (pp. 6240–6263). Philadelphia, PA, United States: Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/1.9781611978971.225\">https://doi.org/10.1137/1.9781611978971.225</a>","ista":"Chambers EW, Fillmore CD, Stephenson ER, Wintraecken M. 2026.Braiding Vineyards. In: Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms. , 6240–6263.","ama":"Chambers EW, Fillmore CD, Stephenson ER, Wintraecken M. Braiding Vineyards. In: Green Larsen K, Saha B, eds. <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>. Philadelphia, PA, United States: Society for Industrial and Applied Mathematics; 2026:6240-6263. doi:<a href=\"https://doi.org/10.1137/1.9781611978971.225\">10.1137/1.9781611978971.225</a>","short":"E.W. Chambers, C.D. Fillmore, E.R. Stephenson, M. Wintraecken, in:, K. Green Larsen, B. Saha (Eds.), Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics, Philadelphia, PA, United States, 2026, pp. 6240–6263."},"department":[{"_id":"HeEd"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Society for Industrial and Applied Mathematics","publication_identifier":{"eisbn":["9781611978971"]},"article_processing_charge":"No","day":"07","arxiv":1,"quality_controlled":"1","date_published":"2026-01-07T00:00:00Z","OA_place":"repository","abstract":[{"text":"In this work, we introduce and study what we believe is an intriguing, and, to the best of our knowledge, previously unknown connection between two fundamental areas in computational topology, namely topological data analysis (TDA) and knot theory. Given a function from a topological space to ℝ, TDA provides tools to simplify and study the importance of topological features: in particular, the 𝑙^𝑡⁢ℎ-dimensional persistence diagram encodes the topological changes (or 𝑙-homology) in the sublevel set as the function value increases into a set of points in the plane. Given a continuous one parameter family of such functions, we can combine the persistence diagrams into an object known as a vineyard, which tracks the evolution of points in the persistence diagram as the function changes. If we further restrict that family of functions to be periodic, we identify the two ends of the vineyard, yielding a closed vineyard. This allows the study of monodromy, which in this context means that following the family of functions for a period permutes the set of points in a non-trivial way. Recent work has studied monodromy in the directional persistent homology transform, demonstrating some interesting connections between an input shape and monodromy in the persistent homology transform for 0-dimensional homology embedded in ℝ^2.\r\nIn this work, given a link and a value 𝑙, we construct a topological space (based on the given link) and periodic family of functions on this space (based on the Euclidean distance function), such that the closed 𝑙-vineyard contains this link. This shows that vineyards are topologically as rich as one could possibly hope, suggesting many future directions of work. Importantly, it has at least two immediate consequences we explicitly point out:\r\n1.\tMonodromy of any periodicity can occur in a 𝑙-vineyard for any 𝑙. This answers a variant of a question by Arya and collaborators. To exhibit this as a consequence of our first main result we also reformulate monodromy in a more geometric way, which may be of interest in itself.\r\n2.\tTopologically distinguishing closed vineyards is likely to be difficult (from a complexity theory as well as from a practical perspective) because of the difficulty of knot and link recognition, which have strong connections to many NP-hard problems.","lang":"eng"}],"page":"6240-6263","year":"2026","external_id":{"arxiv":["2504.11203"]},"related_material":{"record":[{"status":"public","id":"21051","relation":"earlier_version"}]},"date_created":"2026-01-28T12:58:16Z","oa_version":"Preprint","_id":"21056","language":[{"iso":"eng"}],"publication":"Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms","title":"Braiding Vineyards","status":"public","OA_type":"green","date_updated":"2026-02-16T08:06:23Z","publication_status":"published","editor":[{"last_name":"Green Larsen","full_name":"Green Larsen, Kasper","first_name":"Kasper"},{"last_name":"Saha","full_name":"Saha, Barna","first_name":"Barna"}],"month":"01","author":[{"first_name":"Erin W.","full_name":"Chambers, Erin W.","last_name":"Chambers"},{"full_name":"Fillmore, Christopher D","first_name":"Christopher D","last_name":"Fillmore","id":"35638A5C-AAC7-11E9-B0BF-5503E6697425"},{"full_name":"Stephenson, Elizabeth R","orcid":"0000-0002-6862-208X","first_name":"Elizabeth R","last_name":"Stephenson","id":"2D04F932-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-7472-2220","first_name":"Mathijs","full_name":"Wintraecken, Mathijs","last_name":"Wintraecken","id":"307CFBC8-F248-11E8-B48F-1D18A9856A87"}]},{"citation":{"chicago":"Montagna, Francesco. “On the Identifiability of Causal Graphs with Multiple Environments.” In <i>The 14th International Conference on Learning Representations</i>. OpenReview, n.d.","apa":"Montagna, F. (n.d.). On the identifiability of causal graphs with multiple environments. In <i>The 14th International Conference on Learning Representations</i>. Rio de Janeiro, Brazil: OpenReview.","ieee":"F. Montagna, “On the identifiability of causal graphs with multiple environments,” in <i>The 14th International Conference on Learning Representations</i>, Rio de Janeiro, Brazil.","ista":"Montagna F. On the identifiability of causal graphs with multiple environments. The 14th International Conference on Learning Representations. ICLR: International Conference on Learning Representations.","mla":"Montagna, Francesco. “On the Identifiability of Causal Graphs with Multiple Environments.” <i>The 14th International Conference on Learning Representations</i>, OpenReview.","short":"F. Montagna, in:, The 14th International Conference on Learning Representations, OpenReview, n.d.","ama":"Montagna F. On the identifiability of causal graphs with multiple environments. In: <i>The 14th International Conference on Learning Representations</i>. OpenReview."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"FrLo"}],"publisher":"OpenReview","article_processing_charge":"No","arxiv":1,"day":"11","date_published":"2026-02-11T00:00:00Z","OA_place":"publisher","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2510.13583"}],"conference":{"location":"Rio de Janeiro, Brazil","end_date":"2026-04-27","name":"ICLR: International Conference on Learning Representations","start_date":"2026-04-23"},"type":"conference","oa":1,"has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"corr_author":"1","_id":"21113","language":[{"iso":"eng"}],"publication":"The 14th International Conference on Learning Representations","title":"On the identifiability of causal graphs with multiple environments","status":"public","ddc":["000"],"OA_type":"gold","date_updated":"2026-02-16T08:15:11Z","publication_status":"accepted","author":[{"id":"353afc8e-19f4-11f0-9db9-811f1723c83f","last_name":"Montagna","first_name":"Francesco","full_name":"Montagna, Francesco"}],"month":"02","abstract":[{"text":"Causal discovery from i.i.d. observational data is known to be generally ill-posed. We demonstrate that if we have access to the distribution induced by a structural causal model, and additional data from (in the best case) only two environments that sufficiently differ in the noise statistics, the unique causal graph is identifiable. Notably, this is the first result in the literature that guarantees the entire causal graph recovery with a constant number of environments and arbitrary nonlinear mechanisms. Our only constraint is the Gaussianity of the noise terms; however, we propose potential ways to relax this requirement. Of interest on its own, we expand on the well-known duality between independent component analysis (ICA) and causal discovery; recent advancements have shown that nonlinear ICA can be solved from multiple environments, at least as many as the number of sources: we show that the same can be achieved for causal discovery while having access to much less auxiliary information.","lang":"eng"}],"year":"2026","external_id":{"arxiv":["2510.13583"]},"date_created":"2026-01-30T08:16:25Z","oa_version":"Published Version"},{"abstract":[{"lang":"eng","text":"Quantifying cell morphology is central to understanding cellular regulation, fate, and heterogeneity, yet conventional image-based analyses often struggle with diverse or irregular shapes. We present a computational framework that uses topological data analysis to characterise and compare single-cell morphologies from fluorescence microscopy. Each cell is represented by its contour together with the position of its nucleus, from which we construct a filtration based on a radial distance function and derive a persistence diagram encoding the shape’s topological evolution. The similarity between two cells is quantified using the 2-Wasserstein distance between their diagrams, yielding a shape distance we call the PH distance. We apply this method to two representative experimental systems—primary human mesenchymal stem cells (hMSCs) and HeLa cells—and show that PH distances enable the detection of outliers in those systems, the identification of sub-populations, and the quantification of shape heterogeneity. We benchmark PH against three established contour-based distances (aspect ratio, Fourier descriptors, and elastic shape analysis) and show that PH offers better separation between cell types and greater robustness when clustering heterogeneous populations. Together, these results demonstrate that persistent-homology-based signatures provide a principled and sensitive approach for analysing cell morphology in settings where traditional geometric or image-based descriptors are insufficient."}],"volume":22,"year":"2026","external_id":{"pmid":["41604421"]},"date_created":"2026-01-30T10:36:32Z","related_material":{"link":[{"relation":"software","url":"https://github.com/yossibokorbleile/correa"}]},"oa_version":"Published Version","language":[{"iso":"eng"}],"publication":"PLoS Computational Biology","_id":"21115","title":"Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population","scopus_import":"1","status":"public","file":[{"checksum":"3899d929ee9be0453c95524e49992d72","file_size":8908746,"success":1,"date_created":"2026-02-10T07:13:06Z","date_updated":"2026-02-10T07:13:06Z","file_id":"21204","creator":"dernst","relation":"main_file","content_type":"application/pdf","access_level":"open_access","file_name":"2026_PloSCompBio_Bleile.pdf"}],"PlanS_conform":"1","article_type":"original","date_updated":"2026-02-12T14:23:54Z","publication_status":"published","OA_type":"gold","ddc":["000"],"author":[{"id":"920a7385-7995-11ef-9bfd-8c434cd8f3c2","last_name":"Bleile","first_name":"Yossi","orcid":"0000-0002-4861-9174","full_name":"Bleile, Yossi"},{"last_name":"Yadav","full_name":"Yadav, Pooja","first_name":"Pooja"},{"first_name":"Patrice","full_name":"Koehl, Patrice","last_name":"Koehl"},{"first_name":"Florian","full_name":"Rehfeldt, Florian","last_name":"Rehfeldt"}],"month":"01","file_date_updated":"2026-02-10T07:13:06Z","type":"journal_article","pmid":1,"doi":"10.1371/journal.pcbi.1013890","oa":1,"article_number":"e1013890","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","acknowledgement":"We thank Stephan Huckemann, Katharine Turner, Benjamin Eltzner, Stephan Tillmann, Fariza Rashid, Vanessa Robins, and Lamiae Azizi for many useful discussions at various stages of this project. FR and PY gratefully acknowledge Matthias Weiss (Experimental Physics I, University of Bayreuth, Germany) for granting access to cell culture and laboratories, as well as funding consumables and the fruitful discussion that contributed to this work. For open access purposes, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission.","corr_author":"1","citation":{"chicago":"Bleile, Yossi, Pooja Yadav, Patrice Koehl, and Florian Rehfeldt. “Persistence Diagrams as Morphological Signatures of Cells: A Method to Measure and Compare Cells within a Population.” <i>PLoS Computational Biology</i>. Public Library of Science, 2026. <a href=\"https://doi.org/10.1371/journal.pcbi.1013890\">https://doi.org/10.1371/journal.pcbi.1013890</a>.","ieee":"Y. Bleile, P. Yadav, P. Koehl, and F. Rehfeldt, “Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population,” <i>PLoS Computational Biology</i>, vol. 22. Public Library of Science, 2026.","apa":"Bleile, Y., Yadav, P., Koehl, P., &#38; Rehfeldt, F. (2026). Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population. <i>PLoS Computational Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pcbi.1013890\">https://doi.org/10.1371/journal.pcbi.1013890</a>","ista":"Bleile Y, Yadav P, Koehl P, Rehfeldt F. 2026. Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population. PLoS Computational Biology. 22, e1013890.","mla":"Bleile, Yossi, et al. “Persistence Diagrams as Morphological Signatures of Cells: A Method to Measure and Compare Cells within a Population.” <i>PLoS Computational Biology</i>, vol. 22, e1013890, Public Library of Science, 2026, doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1013890\">10.1371/journal.pcbi.1013890</a>.","short":"Y. Bleile, P. Yadav, P. Koehl, F. Rehfeldt, PLoS Computational Biology 22 (2026).","ama":"Bleile Y, Yadav P, Koehl P, Rehfeldt F. Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population. <i>PLoS Computational Biology</i>. 2026;22. doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1013890\">10.1371/journal.pcbi.1013890</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"HeEd"}],"publisher":"Public Library of Science","article_processing_charge":"Yes","publication_identifier":{"issn":["1553-7358"]},"quality_controlled":"1","DOAJ_listed":"1","day":"28","intvolume":"        22","OA_place":"publisher","date_published":"2026-01-28T00:00:00Z"},{"year":"2026","oa":1,"doi":"10.15479/AT-ISTA-21116","abstract":[{"text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analyzed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find that the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on Muller element F (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes.","lang":"eng"}],"file_date_updated":"2026-01-30T11:00:56Z","type":"research_data","corr_author":"1","oa_version":"Published Version","has_accepted_license":"1","date_created":"2026-01-30T11:04:14Z","keyword":["Schizophora","sex chromosomes","sex-chromosome turnover","Diptera","genomic features","out-of-X movement."],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"title":"Research Data for \"Causes and consequences of sex-chromosome turnovers in Diptera\"","status":"public","article_processing_charge":"No","file":[{"date_created":"2026-01-30T11:00:24Z","success":1,"date_updated":"2026-01-30T11:00:24Z","file_size":1201,"checksum":"0b79be6229f2ad9ac117ef00fc4f5c0e","relation":"main_file","access_level":"open_access","content_type":"text/plain","file_name":"README.txt","file_id":"21117","creator":"llayanaf"},{"date_created":"2026-01-30T11:00:36Z","success":1,"date_updated":"2026-01-30T11:00:36Z","checksum":"a3cda72e4177fa1e5d3f0f6a88f8a79b","file_size":572403,"access_level":"open_access","content_type":"application/zip","relation":"main_file","file_name":"Supplementary_Tables.zip","creator":"llayanaf","file_id":"21118"},{"creator":"llayanaf","file_id":"21119","access_level":"open_access","content_type":"application/zip","relation":"main_file","file_name":"Supplementary_Datasets.zip","file_size":19054553,"checksum":"efb5b64698d6ca9e7b675204f6fc1c29","success":1,"date_created":"2026-01-30T11:00:48Z","date_updated":"2026-01-30T11:00:48Z"},{"file_size":4575,"checksum":"254e050f648e9783ba8fe11adb3b49db","date_updated":"2026-01-30T11:00:56Z","date_created":"2026-01-30T11:00:56Z","success":1,"creator":"llayanaf","file_id":"21120","file_name":"Perl_scripts.zip","content_type":"application/zip","access_level":"open_access","relation":"main_file"}],"department":[{"_id":"BeVi"}],"_id":"21116","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","citation":{"mla":"Layana Franco, Lorena Alexandra, et al. <i>Research Data for “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21116\">10.15479/AT-ISTA-21116</a>.","ista":"Layana Franco LA, Toups MA, Vicoso B. 2026. Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21116\">10.15479/AT-ISTA-21116</a>.","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Research Data for ‘Causes and Consequences of Sex-Chromosome Turnovers in Diptera.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21116\">https://doi.org/10.15479/AT-ISTA-21116</a>.","ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera.’” Institute of Science and Technology Austria, 2026.","apa":"Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2026). Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21116\">https://doi.org/10.15479/AT-ISTA-21116</a>","ama":"Layana Franco LA, Toups MA, Vicoso B. Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21116\">10.15479/AT-ISTA-21116</a>","short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, (2026)."},"publisher":"Institute of Science and Technology Austria","date_published":"2026-01-02T00:00:00Z","author":[{"full_name":"Layana Franco, Lorena Alexandra","orcid":"0000-0002-1253-6297","first_name":"Lorena Alexandra","last_name":"Layana Franco","id":"02814589-eb8f-11eb-b029-a70074f3f18f"},{"full_name":"Toups, Melissa A","orcid":"0000-0002-9752-7380","first_name":"Melissa A","last_name":"Toups","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306","first_name":"Beatriz","last_name":"Vicoso","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87"}],"month":"01","day":"2","date_updated":"2026-02-12T12:58:00Z"},{"article_processing_charge":"No","publication_identifier":{"issn":["1937-5093"],"eissn":["1937-5077"]},"department":[{"_id":"JaMa"}],"citation":{"mla":"Brigati, Giovanni, et al. “Hypocoercivity Meets Lifts.” <i>Kinetic and Related Models</i>, vol. 20, American Institute of Mathematical Sciences, 2026, pp. 34–55, doi:<a href=\"https://doi.org/10.3934/krm.2025020\">10.3934/krm.2025020</a>.","ista":"Brigati G, Lörler F, Wang L. 2026. Hypocoercivity meets lifts. Kinetic and Related Models. 20, 34–55.","apa":"Brigati, G., Lörler, F., &#38; Wang, L. (2026). Hypocoercivity meets lifts. <i>Kinetic and Related Models</i>. American Institute of Mathematical Sciences. <a href=\"https://doi.org/10.3934/krm.2025020\">https://doi.org/10.3934/krm.2025020</a>","ieee":"G. Brigati, F. Lörler, and L. Wang, “Hypocoercivity meets lifts,” <i>Kinetic and Related Models</i>, vol. 20. American Institute of Mathematical Sciences, pp. 34–55, 2026.","chicago":"Brigati, Giovanni, Francis Lörler, and Lihan Wang. “Hypocoercivity Meets Lifts.” <i>Kinetic and Related Models</i>. American Institute of Mathematical Sciences, 2026. <a href=\"https://doi.org/10.3934/krm.2025020\">https://doi.org/10.3934/krm.2025020</a>.","ama":"Brigati G, Lörler F, Wang L. Hypocoercivity meets lifts. <i>Kinetic and Related Models</i>. 2026;20:34-55. doi:<a href=\"https://doi.org/10.3934/krm.2025020\">10.3934/krm.2025020</a>","short":"G. Brigati, F. Lörler, L. Wang, Kinetic and Related Models 20 (2026) 34–55."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"American Institute of Mathematical Sciences","OA_place":"repository","intvolume":"        20","date_published":"2026-02-01T00:00:00Z","quality_controlled":"1","arxiv":1,"day":"01","doi":"10.3934/krm.2025020","oa":1,"type":"journal_article","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2412.10890","open_access":"1"}],"acknowledgement":"We would like to thank Andreas Eberle and Gabriel Stoltz for many helpful discussions. GB\r\nhas received funding from the European Union Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101034413. FL wurde gefördert durch die Deutsche Forschungsgemeinschaft (DFG) im Rahmen der Exzellenzstrategie des Bundes und der Länder – GZ2047/1, Projekt-ID 390685813. LW is supported by the National Science Foundation via grant DMS-2407166. He is also indebted to the Mathematical Sciences department at Carnegie Mellon University for partly supporting his visit to Europe in July 2024. Part of this work was completed when GB and LW were visiting the Institute for Applied Mathematics in Bonn. GB and LW would like to thank IAM for their hospitality.","title":"Hypocoercivity meets lifts","status":"public","scopus_import":"1","article_type":"original","language":[{"iso":"eng"}],"publication":"Kinetic and Related Models","_id":"21132","month":"02","author":[{"id":"63ff57e8-1fbb-11ee-88f2-f558ffc59cf1","last_name":"Brigati","full_name":"Brigati, Giovanni","first_name":"Giovanni"},{"last_name":"Lörler","first_name":"Francis","full_name":"Lörler, Francis"},{"last_name":"Wang","first_name":"Lihan","full_name":"Wang, Lihan"}],"date_updated":"2026-02-16T10:02:47Z","publication_status":"epub_ahead","OA_type":"green","project":[{"grant_number":"101034413","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"}],"volume":20,"year":"2026","page":"34-55","ec_funded":1,"abstract":[{"lang":"eng","text":"We unify the variational hypocoercivity framework established by D. Albritton, S. Armstrong, J.-C. Mourrat, and M. Novack [2], with the notion of second-order lifts of reversible diffusion processes, recently introduced by A. Eberle and the second author [30]. We give an abstract, yet fully constructive, presentation of the theory, so that it can be applied to a large class of linear kinetic equations. As this hypocoercivity technique does not twist the reference norm, we can recover accurate and sharp convergence rates in various models. Among those, adaptive Langevin dynamics (ALD) is discussed in full detail and we show that for near-quadratic potentials, with suitable choices of parameters, it is a near-optimal second-order lift of the overdamped Langevin dynamics. As a further consequence, we observe that the Generalised Langevin Equation (GLE) is also a second-order lift, as the standard (kinetic) Langevin dynamics are, of the overdamped Langevin dynamics. Then, convergence of (GLE) cannot exceed ballistic speed, i.e. the square root of the rate of the overdamped regime. We illustrate this phenomenon with explicit computations in a benchmark Gaussian case."}],"oa_version":"Preprint","date_created":"2026-02-01T23:01:43Z","external_id":{"arxiv":["2412.10890"]}},{"article_processing_charge":"No","publication_identifier":{"isbn":["9798400723414"]},"citation":{"short":"L. Elbeheiry, M.J. Sammler, R. Krebbers, D. Dreyer, D. Garg, in:, Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs, Association for Computing Machinery, 2026, pp. 339–352.","ama":"Elbeheiry L, Sammler MJ, Krebbers R, Dreyer D, Garg D. A recipe for modular verification of generic tree traversals. In: <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>. Association for Computing Machinery; 2026:339-352. doi:<a href=\"https://doi.org/10.1145/3779031.3779110\">10.1145/3779031.3779110</a>","ista":"Elbeheiry L, Sammler MJ, Krebbers R, Dreyer D, Garg D. 2026. A recipe for modular verification of generic tree traversals. Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs. CPP: Conference on Certified Programs and Proofs, 339–352.","apa":"Elbeheiry, L., Sammler, M. J., Krebbers, R., Dreyer, D., &#38; Garg, D. (2026). A recipe for modular verification of generic tree traversals. In <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i> (pp. 339–352). Rennes, France: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3779031.3779110\">https://doi.org/10.1145/3779031.3779110</a>","chicago":"Elbeheiry, Laila, Michael Joachim Sammler, Robbert Krebbers, Derek Dreyer, and Deepak Garg. “A Recipe for Modular Verification of Generic Tree Traversals.” In <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>, 339–52. Association for Computing Machinery, 2026. <a href=\"https://doi.org/10.1145/3779031.3779110\">https://doi.org/10.1145/3779031.3779110</a>.","ieee":"L. Elbeheiry, M. J. Sammler, R. Krebbers, D. Dreyer, and D. Garg, “A recipe for modular verification of generic tree traversals,” in <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>, Rennes, France, 2026, pp. 339–352.","mla":"Elbeheiry, Laila, et al. “A Recipe for Modular Verification of Generic Tree Traversals.” <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>, Association for Computing Machinery, 2026, pp. 339–52, doi:<a href=\"https://doi.org/10.1145/3779031.3779110\">10.1145/3779031.3779110</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MiSa"}],"publisher":"Association for Computing Machinery","OA_place":"publisher","date_published":"2026-01-08T00:00:00Z","quality_controlled":"1","day":"08","doi":"10.1145/3779031.3779110","oa":1,"file_date_updated":"2026-02-16T08:40:29Z","type":"conference","conference":{"end_date":"2026-01-13","location":"Rennes, France","start_date":"2026-01-12","name":"CPP: Conference on Certified Programs and Proofs"},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","acknowledgement":"We thank the anonymous reviewers for their insightful suggestions. This research is supported in part by generous awards from Android Security’s ASPIRE program and from Google Research. The third author is supported, in part, by ERC grant COCONUT (grant no. 101171349), funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.","title":"A recipe for modular verification of generic tree traversals","scopus_import":"1","status":"public","file":[{"creator":"dernst","file_id":"21225","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_name":"2026_CPP_Elbeheiry.pdf","file_size":811872,"checksum":"7df99991493e907d83a197151f378e3e","success":1,"date_created":"2026-02-16T08:40:29Z","date_updated":"2026-02-16T08:40:29Z"}],"publication":"Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs","language":[{"iso":"eng"}],"_id":"21133","author":[{"first_name":"Laila","full_name":"Elbeheiry, Laila","last_name":"Elbeheiry"},{"id":"510d3901-2a03-11ee-914d-d9ae9011f0a7","last_name":"Sammler","first_name":"Michael Joachim","full_name":"Sammler, Michael Joachim"},{"full_name":"Krebbers, Robbert","first_name":"Robbert","last_name":"Krebbers"},{"last_name":"Dreyer","full_name":"Dreyer, Derek","first_name":"Derek"},{"last_name":"Garg","first_name":"Deepak","full_name":"Garg, Deepak"}],"month":"01","date_updated":"2026-02-16T08:43:24Z","publication_status":"published","ddc":["000"],"OA_type":"gold","year":"2026","page":"339-352","abstract":[{"lang":"eng","text":"Data structures based on trees and tree traversals are ubiquitous in computer systems. Many low-level programs, including some implementations of critical systems like page tables and the web browser DOM, rely on generic tree-traversal functions that traverse tree nodes in a pre-determined order, applying a client-provided operation to each visited node. Developing a general approach to specifying and verifying such traversals is tricky since the client-provided per-node operation can be stateful and may potentially depend on or modify the structure of the tree being traversed.\r\nIn this paper, we present a recipe for (semi-)automated verification of such generic, stateful tree traversals. Our recipe is (a) general: it applies to a range of tree traversals, in particular, pre-, post- and in-order depth-first traversals; (b) modular: parts of a traversal’s proof can be reused in verifying other similar traversals; (c) expressive: using the specification of a tree traversal, we can verify clients that use the traversal in a variety of different ways; and (d) automatable: many proof obligations can be discharged automatically.\r\nAt the heart of our recipe is a novel use of tree zippers to represent a logical abstraction of the tree traversal state, and zipper transitions as an abstraction of traversal steps. We realize our recipe in the RefinedC framework in Rocq, which allows us to verify a number of different tree traversals and their clients written in C."}],"oa_version":"Published Version","date_created":"2026-02-01T23:01:43Z"},{"acknowledgement":"This work was supported by NIH grants 1U01NS132158 and R01HD104969. We thank the reviewers for their constructive feedback.","conference":{"name":"EMA4MICCAI: Efficient Medical Artificial Intelligence","start_date":"2025-09-23","location":"Daejeon, South Korea","end_date":"2025-09-23"},"main_file_link":[{"url":"https://doi.org/10.1101/2024.09.07.611785","open_access":"1"}],"type":"conference","oa":1,"doi":"10.1007/978-3-032-13961-0_26","day":"03","quality_controlled":"1","date_published":"2026-01-03T00:00:00Z","OA_place":"repository","intvolume":"     16318","publisher":"Springer Nature","citation":{"mla":"Troidl, Jakob, et al. “Niiv: Interactive Self-Supervised Neural Implicit Isotropic Volume Reconstruction.” <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>, vol. 16318, Springer Nature, 2026, pp. 257–67, doi:<a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">10.1007/978-3-032-13961-0_26</a>.","ista":"Troidl J, Liang Y, Beyer J, Tavakoli M, Danzl JG, Hadwiger M, Pfister H, Tompkin J. 2026. niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction. 1st International Workshop on Efficient Medical Artificial Intelligence. EMA4MICCAI: Efficient Medical Artificial Intelligence, LNCS, vol. 16318, 257–267.","ieee":"J. Troidl <i>et al.</i>, “niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction,” in <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>, Daejeon, South Korea, 2026, vol. 16318, pp. 257–267.","chicago":"Troidl, Jakob, Yiqing Liang, Johanna Beyer, Mojtaba Tavakoli, Johann G Danzl, Markus Hadwiger, Hanspeter Pfister, and James Tompkin. “Niiv: Interactive Self-Supervised Neural Implicit Isotropic Volume Reconstruction.” In <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>, 16318:257–67. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">https://doi.org/10.1007/978-3-032-13961-0_26</a>.","apa":"Troidl, J., Liang, Y., Beyer, J., Tavakoli, M., Danzl, J. G., Hadwiger, M., … Tompkin, J. (2026). niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction. In <i>1st International Workshop on Efficient Medical Artificial Intelligence</i> (Vol. 16318, pp. 257–267). Daejeon, South Korea: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">https://doi.org/10.1007/978-3-032-13961-0_26</a>","ama":"Troidl J, Liang Y, Beyer J, et al. niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction. In: <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>. Vol 16318. Springer Nature; 2026:257-267. doi:<a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">10.1007/978-3-032-13961-0_26</a>","short":"J. Troidl, Y. Liang, J. Beyer, M. Tavakoli, J.G. Danzl, M. Hadwiger, H. Pfister, J. Tompkin, in:, 1st International Workshop on Efficient Medical Artificial Intelligence, Springer Nature, 2026, pp. 257–267."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","alternative_title":["LNCS"],"department":[{"_id":"JoDa"}],"publication_identifier":{"isbn":["9783032139603"],"eissn":["1611-3349"],"issn":["0302-9743"]},"article_processing_charge":"No","related_material":{"link":[{"relation":"software","url":"https://github.com/jakobtroidl/niiv-miccai"}]},"date_created":"2026-02-01T23:01:44Z","oa_version":"Preprint","abstract":[{"lang":"eng","text":"Three-dimensional (3D) microscopy data is often anisotropic with significantly lower resolution (up to 8x) along the z axis than along the xy axes. Computationally generating plausible isotropic resolution from anisotropic imaging data would benefit the visual analysis of large-scale volumes. This paper proposes niiv, a self-supervised method for isotropic reconstruction of 3D microscopy data that can quickly produce images at arbitrary output resolutions. The representation embeds a learned latent code within a neural field that describes the implicit higher-resolution isotropic image region. We use an attention-guided latent interpolation approach, which allows flexible information exchange over a local latent neighborhood. Under isotropic volume assumptions, we self-supervise this representation on low-/high-resolution lateral image pairs to reconstruct an isotropic volume from low-resolution axial images. We evaluate our method on simulated and real anisotropic electron (EM) and light microscopy (LM) data. Compared to diffusion-based baselines, niiv shows improved reconstruction quality (+1 dB PSNR) and is over three orders of magnitude faster (1,000x) to infer. Specifically, niiv reconstructs a 128^3 voxel volume in 2/10th of a second, renderable at varying (continuous) high resolutions for display. Our code is available at https://github.com/jakobtroidl/niiv-miccai."}],"page":"257-267","year":"2026","volume":16318,"OA_type":"green","publication_status":"published","date_updated":"2026-02-16T08:50:50Z","month":"01","author":[{"last_name":"Troidl","first_name":"Jakob","full_name":"Troidl, Jakob"},{"full_name":"Liang, Yiqing","first_name":"Yiqing","last_name":"Liang"},{"last_name":"Beyer","first_name":"Johanna","full_name":"Beyer, Johanna"},{"id":"3A0A06F4-F248-11E8-B48F-1D18A9856A87","last_name":"Tavakoli","first_name":"Mojtaba","orcid":"0000-0002-7667-6854","full_name":"Tavakoli, Mojtaba"},{"full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973","first_name":"Johann G","last_name":"Danzl","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hadwiger","first_name":"Markus","full_name":"Hadwiger, Markus"},{"first_name":"Hanspeter","full_name":"Pfister, Hanspeter","last_name":"Pfister"},{"full_name":"Tompkin, James","first_name":"James","last_name":"Tompkin"}],"_id":"21135","language":[{"iso":"eng"}],"publication":"1st International Workshop on Efficient Medical Artificial Intelligence","status":"public","scopus_import":"1","title":"niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction"},{"status":"public","title":"Faster algorithms for packing forests in graphs and related problems","_id":"21140","language":[{"iso":"eng"}],"publication":"Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms","month":"01","author":[{"full_name":"Arkhipov, Pavel","first_name":"Pavel","last_name":"Arkhipov","id":"b25f2ab2-1fed-11ee-8599-fe02d211784f"},{"first_name":"Vladimir","full_name":"Kolmogorov, Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kolmogorov"}],"OA_type":"green","publication_status":"published","date_updated":"2026-02-16T09:18:33Z","year":"2026","abstract":[{"lang":"eng","text":"We consider several problems related to packing forests in graphs. The first one is to find k edge-disjoint forests in a directed graph G of maximal size such that the indegree of each vertex in these forests is at most k. We describe a min-max characterization for this problem and show that it can be solved in almost linear time for fixed k, extending the algorithm of [Gabow, 1995]. Specifically, the complexity is O(kδm log n), where n, m are the number of vertices and edges in G respectively, and δ = max{1, k − kG}, where kG is the edge connectivity of the graph. Using our solution to this problem, we improve complexities for two existing applications:(1) k-forest problem: find k forests in an undirected graph G maximizing the number of edges in their union. We show how to solve this problem in O(k3 min{kn, m} log2 n + k · MAXFLOW(m, m) log n) time, breaking the Ok(n3/2) complexity barrier of previously known approaches.(2) Directed edge-connectivity augmentation problem: find a smallest set of directed edges whose addition to the given directed graph makes it strongly k-connected. We improve the deterministic complexity for this problem from O(kδ(m + δn) log n) [Gabow, STOC 1994] to O(kδm log n). A similar approach with the same complexity also works for the undirected version of the problem."}],"page":"4023-4042","oa_version":"Preprint","external_id":{"arxiv":["2409.20314"]},"date_created":"2026-02-05T10:51:34Z","publication_identifier":{"eisbn":["9781611978971"]},"article_processing_charge":"No","publisher":"Society for Industrial and Applied Mathematics","citation":{"mla":"Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing Forests in Graphs and Related Problems.” <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Society for Industrial and Applied Mathematics, 2026, pp. 4023–42, doi:<a href=\"https://doi.org/10.1137/1.9781611978971.148\">10.1137/1.9781611978971.148</a>.","apa":"Arkhipov, P., &#38; Kolmogorov, V. (2026). Faster algorithms for packing forests in graphs and related problems. In <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i> (pp. 4023–4042). Vancouver, Canada: Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/1.9781611978971.148\">https://doi.org/10.1137/1.9781611978971.148</a>","ieee":"P. Arkhipov and V. Kolmogorov, “Faster algorithms for packing forests in graphs and related problems,” in <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Vancouver, Canada, 2026, pp. 4023–4042.","chicago":"Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing Forests in Graphs and Related Problems.” In <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, 4023–42. Society for Industrial and Applied Mathematics, 2026. <a href=\"https://doi.org/10.1137/1.9781611978971.148\">https://doi.org/10.1137/1.9781611978971.148</a>.","ista":"Arkhipov P, Kolmogorov V. 2026. Faster algorithms for packing forests in graphs and related problems. Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 4023–4042.","ama":"Arkhipov P, Kolmogorov V. Faster algorithms for packing forests in graphs and related problems. In: <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>. Society for Industrial and Applied Mathematics; 2026:4023-4042. doi:<a href=\"https://doi.org/10.1137/1.9781611978971.148\">10.1137/1.9781611978971.148</a>","short":"P. Arkhipov, V. Kolmogorov, in:, Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics, 2026, pp. 4023–4042."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"VlKo"}],"date_published":"2026-01-07T00:00:00Z","OA_place":"repository","day":"07","arxiv":1,"quality_controlled":"1","oa":1,"doi":"10.1137/1.9781611978971.148","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2409.20314"}],"conference":{"name":"SODA: Symposium on Discrete Algorithms","start_date":"2026-01-11","location":"Vancouver, Canada","end_date":"2026-01-14"},"type":"conference","corr_author":"1"},{"article_processing_charge":"No","publisher":"Institute of Science and Technology Austria","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Becker LM, Schanda P, Chipot C. Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21145\">10.15479/AT-ISTA-21145</a>","short":"L.M. Becker, P. Schanda, C. Chipot, (2026).","mla":"Becker, Lea Marie, et al. <i>Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21145\">10.15479/AT-ISTA-21145</a>.","ista":"Becker LM, Schanda P, Chipot C. 2026. Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21145\">10.15479/AT-ISTA-21145</a>.","chicago":"Becker, Lea Marie, Paul Schanda, and Christophe Chipot. “Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21145\">https://doi.org/10.15479/AT-ISTA-21145</a>.","apa":"Becker, L. M., Schanda, P., &#38; Chipot, C. (2026). Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21145\">https://doi.org/10.15479/AT-ISTA-21145</a>","ieee":"L. M. Becker, P. Schanda, and C. Chipot, “Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2026."},"department":[{"_id":"GradSch"},{"_id":"PaSc"}],"date_published":"2026-02-09T00:00:00Z","day":"09","doi":"10.15479/AT-ISTA-21145","oa":1,"type":"research_data","file_date_updated":"2026-02-05T13:52:41Z","acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"corr_author":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"acknowledgement":"We thank Nikolai R. Skrynnikov and Olga O. Lebedenko (St. Petersburg) for insightful discussions and for performing exploratory MD simulations. We are grateful to Tobias Schubeis (Lyon) for advice with GB1 crystallization, and Rebecca Schmid for initial crystallization trials.\r\nWe thank Sebastian Falkner for assistance with constructing the structural model of the IgG:GB1 complex.\r\nThis research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank Petra Rovó and Margarita Valhondo Falcón for excellent support of the NMR facility.\r\nLea M. Becker is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (grant no. PR10660EAW01). Christophe Chipot acknowledges the European Research Council (grant project 101097272 ``MilliInMicro'') and the Métropole du Grand Nancy (grant project ``ARC''). BM07-FIP2 is supported by the French ANR PIA3 (France 2030) EquipEx+ project MAGNIFIX under grant agreement ANR-21-ESRE-0011.","has_accepted_license":"1","status":"public","file":[{"file_size":4263,"checksum":"02a419cce8cea450bc952f35488d2df5","date_updated":"2026-02-05T13:52:37Z","date_created":"2026-02-05T13:52:37Z","file_id":"21146","creator":"lbecker","file_name":"README.txt","relation":"table_of_contents","content_type":"text/plain","access_level":"open_access"},{"checksum":"b0b82b1aa73985b0b308a3fa52d21aea","file_size":50647107,"date_updated":"2026-02-05T13:52:41Z","date_created":"2026-02-05T13:52:41Z","success":1,"file_id":"21147","creator":"lbecker","file_name":"Research_Data.zip","relation":"main_file","access_level":"open_access","content_type":"application/zip"}],"title":"Additional Data for \"Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes\"","_id":"21145","author":[{"full_name":"Becker, Lea Marie","first_name":"Lea Marie","orcid":"0000-0002-6401-5151","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","last_name":"Becker"},{"last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","orcid":"0000-0002-9350-7606","first_name":"Paul","full_name":"Schanda, Paul"},{"first_name":"Christophe","full_name":"Chipot, Christophe","last_name":"Chipot"}],"month":"02","date_updated":"2026-02-18T10:04:44Z","ddc":["572"],"year":"2026","project":[{"grant_number":"26777","_id":"7be609c4-9f16-11ee-852c-85015ce2b9b0","name":"Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches"}],"abstract":[{"lang":"eng","text":"Protein conformational energy landscapes are shaped not only by intramolecular interactions but also by their environment. In protein crystals and protein-protein complexes, intermolecular contacts alter this energy landscape, but the exact nature of this alteration is difficult to decipher. Understanding how the crystal lattice affects protein dynamics is crucial for crystallography-based studies of motion, yet its influence on collective motions remains unclear. Aromatic ring flips in the hydrophobic core represent sensitive probes of such dynamics. Here, we compare the kinetics of aromatic ring flips in the protein GB1 in crystals, in complex with its binding partner IgG, and in solution, combining advanced isotope labeling with quantitative NMR methods. We show that rings in the core flip nearly a thousand times less frequently in crystals than in solution. Enhanced-sampling molecular dynamics simulations, based on a new crystal structure, reproduce these elevated barriers and reveal how the crystal restrains motions. "}],"oa_version":"Published Version","contributor":[{"last_name":"Fu","first_name":"Haohao","contributor_type":"researcher"},{"last_name":"Tatman","id":"71cda2f3-e604-11ee-a1df-da10587eda3f","first_name":"Benjamin","contributor_type":"researcher"},{"first_name":"Matthias","contributor_type":"researcher","last_name":"Dreydoppel"},{"first_name":"Anna","contributor_type":"researcher","id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471","last_name":"Kapitonova"},{"first_name":"Daniel","orcid":"0000-0001-7597-043X","contributor_type":"researcher","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","last_name":"Balazs"},{"last_name":"Weininger","contributor_type":"researcher","first_name":"Ulrich"},{"first_name":"Sylvain","contributor_type":"researcher","last_name":"Engilberge"}],"date_created":"2026-02-05T13:54:39Z","related_material":{"record":[{"id":"20641","relation":"earlier_version","status":"public"}]}},{"volume":136,"project":[{"_id":"7c040762-9f16-11ee-852c-dd79eeee4ab3","name":"Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions","grant_number":"F100403"}],"year":"2026","abstract":[{"text":"We present a general theoretical framework for helical dichroism (HD), establishing an explicit link between chiral resolution and orbital angular momentum (OAM) exchange in light–matter interaction. Tracing microscopic mechanisms of the OAM transfer, we derive rotational selection rules, which establish that HD emerges only from the spin–orbit coupling of light, even for beams without the far-field OAM. Our findings refine the conditions for observing HD, provide a tool to re-examine the outcome of prior experiments, and guide future designs for chiral sensing with structured light.","lang":"eng"}],"oa_version":"Published Version","external_id":{"arxiv":["2505.16393"]},"date_created":"2026-02-06T10:53:17Z","PlanS_conform":"1","article_type":"original","title":"Bottom-up analysis of rovibrational helical dichroism","status":"public","file":[{"file_size":511312,"checksum":"805c929fff9fd4d0e733293eaace67b8","success":1,"date_created":"2026-02-10T11:25:46Z","date_updated":"2026-02-10T11:25:46Z","file_id":"21210","creator":"dernst","relation":"main_file","content_type":"application/pdf","access_level":"open_access","file_name":"2026_PhysicalReviewLetters_Hrast.pdf"}],"scopus_import":"1","_id":"21149","language":[{"iso":"eng"}],"publication":"Physical Review Letters","author":[{"id":"48dbb294-2a9c-11ef-905d-f56be71f0e5d","last_name":"Hrast","full_name":"Hrast, Mateja","first_name":"Mateja"},{"last_name":"Koutentakis","id":"d7b23d3a-9e21-11ec-b482-f76739596b95","full_name":"Koutentakis, Georgios","first_name":"Georgios"},{"orcid":"0000-0003-4074-2570","first_name":"Mikhail","full_name":"Maslov, Mikhail","last_name":"Maslov","id":"2E65BB0E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Lemeshko, Mikhail","orcid":"0000-0002-6990-7802","first_name":"Mikhail","last_name":"Lemeshko","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87"}],"month":"02","OA_type":"hybrid","ddc":["530"],"date_updated":"2026-02-10T11:30:37Z","publication_status":"published","oa":1,"doi":"10.1103/fkf1-1jml","file_date_updated":"2026-02-10T11:25:46Z","type":"journal_article","corr_author":"1","has_accepted_license":"1","acknowledgement":"This research was funded in whole or in part by the Austrian Science Fund (FWF) [10.55776/F1004].","article_number":"053204","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"article_processing_charge":"Yes (via OA deal)","citation":{"short":"M. Hrast, G. Koutentakis, M. Maslov, M. Lemeshko, Physical Review Letters 136 (2026).","ama":"Hrast M, Koutentakis G, Maslov M, Lemeshko M. Bottom-up analysis of rovibrational helical dichroism. <i>Physical Review Letters</i>. 2026;136(5). doi:<a href=\"https://doi.org/10.1103/fkf1-1jml\">10.1103/fkf1-1jml</a>","ista":"Hrast M, Koutentakis G, Maslov M, Lemeshko M. 2026. Bottom-up analysis of rovibrational helical dichroism. Physical Review Letters. 136(5), 053204.","chicago":"Hrast, Mateja, Georgios Koutentakis, Mikhail Maslov, and Mikhail Lemeshko. “Bottom-up Analysis of Rovibrational Helical Dichroism.” <i>Physical Review Letters</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/fkf1-1jml\">https://doi.org/10.1103/fkf1-1jml</a>.","ieee":"M. Hrast, G. Koutentakis, M. Maslov, and M. Lemeshko, “Bottom-up analysis of rovibrational helical dichroism,” <i>Physical Review Letters</i>, vol. 136, no. 5. American Physical Society, 2026.","apa":"Hrast, M., Koutentakis, G., Maslov, M., &#38; Lemeshko, M. (2026). Bottom-up analysis of rovibrational helical dichroism. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/fkf1-1jml\">https://doi.org/10.1103/fkf1-1jml</a>","mla":"Hrast, Mateja, et al. “Bottom-up Analysis of Rovibrational Helical Dichroism.” <i>Physical Review Letters</i>, vol. 136, no. 5, 053204, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/fkf1-1jml\">10.1103/fkf1-1jml</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MiLe"}],"issue":"5","publisher":"American Physical Society","date_published":"2026-02-05T00:00:00Z","OA_place":"publisher","intvolume":"       136","arxiv":1,"day":"05","quality_controlled":"1"},{"volume":17,"year":"2026","abstract":[{"lang":"eng","text":"Vernalization-regulated flowering is vital for wheat yield and geographical distribution, and the diversity of flowering time genes is essential for the breeding of climate-resilient varieties. Sugars have long been recognized in regulating flowering; however, the intrinsic connection between carbohydrate metabolism and vernalization response remains largely unexplored. Here, we identify a fructose 1,6-bisphosphate aldolase (FBA) encoding gene, HtL1/FBA10, as a modulator of heading time variation based on a genome-wide association study utilizing wheat core germplasm collections. Evolutionary analysis shows a decrease in the proportion of haplotype-2 of HtL1, which is linked to delayed flowering, in Chinese and American wheat varieties compared to landraces. Vernalization reduces HtL1/FBA10 phosphorylation levels and  increases  its O-GlcNAcylation, which in turn enhances its enzymatic activity and facilitates VERNALIZATION 1 (VRN1) transcription by regulating histone acetylation at the VRN1 locus. Our findings provide mechanistic insights into the interplay between glucose metabolism and the epigenetic regulation of vernalization in winter wheat."}],"oa_version":"Published Version","date_created":"2026-02-08T23:02:48Z","external_id":{"pmid":["41455723"]},"title":"O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering","file":[{"file_size":4685882,"checksum":"9ae170ec70ba1ab56b6f1ffe67d1de7f","date_created":"2026-02-12T14:33:14Z","success":1,"date_updated":"2026-02-12T14:33:14Z","creator":"dernst","file_id":"21223","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_name":"2026_NatureComm_Yang.pdf"}],"status":"public","scopus_import":"1","PlanS_conform":"1","article_type":"original","publication":"Nature Communications","language":[{"iso":"eng"}],"_id":"21158","month":"01","author":[{"first_name":"Pengfang","full_name":"Yang, Pengfang","last_name":"Yang"},{"last_name":"Liu","full_name":"Liu, Yangyang","first_name":"Yangyang"},{"last_name":"Dong","full_name":"Dong, Qi","first_name":"Qi"},{"first_name":"Yuting","full_name":"Miao, Yuting","last_name":"Miao"},{"full_name":"Zhang, Jianlong","first_name":"Jianlong","last_name":"Zhang"},{"last_name":"Xu","id":"9724dd9d-f591-11ee-bd51-e97ed0652286","full_name":"Xu, Shujuan","first_name":"Shujuan"},{"last_name":"Zhao","full_name":"Zhao, Hong","first_name":"Hong"},{"last_name":"Niu","first_name":"Yuda","full_name":"Niu, Yuda"},{"full_name":"Zhang, Xueyong","first_name":"Xueyong","last_name":"Zhang"},{"last_name":"Xu","full_name":"Xu, Yunyuan","first_name":"Yunyuan"},{"last_name":"Guo","full_name":"Guo, Zifeng","first_name":"Zifeng"},{"last_name":"Xing","full_name":"Xing, Lijing","first_name":"Lijing"},{"first_name":"Kang","full_name":"Chong, Kang","last_name":"Chong"}],"date_updated":"2026-02-12T14:34:24Z","publication_status":"published","ddc":["580"],"OA_type":"gold","doi":"10.1038/s41467-025-67734-0","oa":1,"file_date_updated":"2026-02-12T14:33:14Z","pmid":1,"type":"journal_article","article_number":"999","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","acknowledgement":"This work was supported by the Basic Science Center Project of National Natural Science Foundation of China (32388201) to K.C and the National Natural Science Foundation of China (31970331) to L.X. We thank Dr. Zhuang Lu, Dr. Bin Han and Ms. Jingquan Li (Plant Science Facility of the Institute of Botany, Chinese Academy of Sciences) for their technical assistance in LC-MS/MS assay, small molecule compound analysis and the subcellular localization assay, respectively. We thank Dr. Wei Luo and Dr. Dongfeng Liu for helpful discussions.","article_processing_charge":"Yes","publication_identifier":{"eissn":["2041-1723"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"P. Yang, Y. Liu, Q. Dong, Y. Miao, J. Zhang, S. Xu, H. Zhao, Y. Niu, X. Zhang, Y. Xu, Z. Guo, L. Xing, K. Chong, Nature Communications 17 (2026).","ama":"Yang P, Liu Y, Dong Q, et al. O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-025-67734-0\">10.1038/s41467-025-67734-0</a>","ista":"Yang P, Liu Y, Dong Q, Miao Y, Zhang J, Xu S, Zhao H, Niu Y, Zhang X, Xu Y, Guo Z, Xing L, Chong K. 2026. O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. Nature Communications. 17, 999.","chicago":"Yang, Pengfang, Yangyang Liu, Qi Dong, Yuting Miao, Jianlong Zhang, Shujuan Xu, Hong Zhao, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10 Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-025-67734-0\">https://doi.org/10.1038/s41467-025-67734-0</a>.","ieee":"P. Yang <i>et al.</i>, “O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.","apa":"Yang, P., Liu, Y., Dong, Q., Miao, Y., Zhang, J., Xu, S., … Chong, K. (2026). O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-67734-0\">https://doi.org/10.1038/s41467-025-67734-0</a>","mla":"Yang, Pengfang, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10 Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>, vol. 17, 999, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-025-67734-0\">10.1038/s41467-025-67734-0</a>."},"department":[{"_id":"XiFe"}],"publisher":"Springer Nature","OA_place":"publisher","intvolume":"        17","date_published":"2026-01-27T00:00:00Z","quality_controlled":"1","day":"27","DOAJ_listed":"1"},{"article_processing_charge":"Yes (via OA deal)","publication_identifier":{"issn":["0209-9683"],"eissn":["1439-6912"]},"publisher":"Springer Nature","citation":{"mla":"Kwan, Matthew Alan, et al. “Counting Perfect Matchings in Dirac Hypergraphs.” <i>Combinatorica</i>, vol. 46, 5, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1007/s00493-025-00194-8\">10.1007/s00493-025-00194-8</a>.","chicago":"Kwan, Matthew Alan, Roodabeh Safavi Hemami, and Yiting Wang. “Counting Perfect Matchings in Dirac Hypergraphs.” <i>Combinatorica</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/s00493-025-00194-8\">https://doi.org/10.1007/s00493-025-00194-8</a>.","ieee":"M. A. Kwan, R. Safavi Hemami, and Y. Wang, “Counting perfect matchings in Dirac hypergraphs,” <i>Combinatorica</i>, vol. 46. Springer Nature, 2026.","apa":"Kwan, M. A., Safavi Hemami, R., &#38; Wang, Y. (2026). Counting perfect matchings in Dirac hypergraphs. <i>Combinatorica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00493-025-00194-8\">https://doi.org/10.1007/s00493-025-00194-8</a>","ista":"Kwan MA, Safavi Hemami R, Wang Y. 2026. Counting perfect matchings in Dirac hypergraphs. Combinatorica. 46, 5.","ama":"Kwan MA, Safavi Hemami R, Wang Y. Counting perfect matchings in Dirac hypergraphs. <i>Combinatorica</i>. 2026;46. doi:<a href=\"https://doi.org/10.1007/s00493-025-00194-8\">10.1007/s00493-025-00194-8</a>","short":"M.A. Kwan, R. Safavi Hemami, Y. Wang, Combinatorica 46 (2026)."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MaKw"},{"_id":"MoHe"}],"intvolume":"        46","OA_place":"publisher","date_published":"2026-02-01T00:00:00Z","quality_controlled":"1","arxiv":1,"day":"01","doi":"10.1007/s00493-025-00194-8","oa":1,"type":"journal_article","file_date_updated":"2026-02-16T09:52:38Z","corr_author":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_number":"5","acknowledgement":"We would like to thank the referees for a number of helpful comments and suggestions, which have substantially improved the paper. Open access funding provided by Institute of Science and Technology (IST Austria).","has_accepted_license":"1","scopus_import":"1","status":"public","file":[{"success":1,"date_created":"2026-02-16T09:52:38Z","date_updated":"2026-02-16T09:52:38Z","checksum":"47b0031d90b0e6b9a843f422a1486089","file_size":539646,"relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_name":"2026_Combinatorica_Kwan.pdf","file_id":"21228","creator":"dernst"}],"title":"Counting perfect matchings in Dirac hypergraphs","PlanS_conform":"1","article_type":"original","publication":"Combinatorica","language":[{"iso":"eng"}],"_id":"21159","author":[{"last_name":"Kwan","id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","full_name":"Kwan, Matthew Alan","orcid":"0000-0002-4003-7567","first_name":"Matthew Alan"},{"full_name":"Safavi Hemami, Roodabeh","first_name":"Roodabeh","id":"72ed2640-8972-11ed-ae7b-f9c81ec75154","last_name":"Safavi Hemami"},{"id":"1917d194-076e-11ed-97cd-837255f88785","last_name":"Wang","full_name":"Wang, Yiting","first_name":"Yiting","orcid":"0000-0002-2856-767X"}],"month":"02","publication_status":"published","date_updated":"2026-02-16T09:55:17Z","OA_type":"hybrid","ddc":["510"],"year":"2026","volume":46,"abstract":[{"lang":"eng","text":"One of the foundational theorems of extremal graph theory is Dirac’s theorem, which\r\nsays that if an n-vertex graph G has minimum degree at least n/2, then G has a\r\nHamilton cycle, and therefore a perfect matching (if n is even). Later work by Sárközy,\r\nSelkow and Szemerédi showed that in fact Dirac graphs have many Hamilton cycles\r\nand perfect matchings, culminating in a result of Cuckler and Kahn that gives a precise\r\ndescription of the numbers of Hamilton cycles and perfect matchings in a Dirac graph\r\nG (in terms of an entropy-like parameter of G). In this paper we extend Cuckler\r\nand Kahn’s result to perfect matchings in hypergraphs. For positive integers d < k,\r\nand for n divisible by k, let md (k, n) be the minimum d-degree that ensures the\r\nexistence of a perfect matching in an n-vertex k-uniform hypergraph. In general, it is\r\nan open question to determine (even asymptotically) the values of md (k, n), but we are\r\nnonetheless able to prove an analogue of the Cuckler–Kahn theorem, showing that if\r\nan n-vertex k-uniform hypergraph G has minimum d-degree at least (1+γ )md (k, n)\r\n(for any constantγ > 0), then the number of perfect matchings in G is controlled by\r\nan entropy-like parameter of G. This strengthens cruder estimates arising from work\r\nof Kang–Kelly–Kühn–Osthus–Pfenninger and Pham–Sah–Sawhney–Simkin."}],"oa_version":"Published Version","date_created":"2026-02-08T23:02:49Z","external_id":{"arxiv":["2408.09589"]}},{"abstract":[{"text":"Context. AM Canum Venaticorum (AM CVn) stars are ultra-compact binary systems composed of a white dwarf primary accreting from a hydrogen-deficient donor. They play a crucial role in astrophysics as potential progenitors of Type Ia supernovae and as laboratories for gravitational wave studies. However, their formation and evolutionary history remain incomplete. Three formation channels have been discussed in the literature: the white dwarf, He-star, and cataclysmic variable channels.\r\n\r\nAims. The chemical composition of the accretor atmosphere reflects the material transferred from the donor. In this work we took the first accurate measurements of the fundamental parameters of the accreting white dwarf in ZTF J225237.05−051917.4, including the abundances of key elements such as carbon, nitrogen, and silicon, by analysing ultraviolet spectra obtained with the Hubble Space Telescope (HST). These measurements provide new insight into the evolutionary history of the system and, together with existing optical observations, establish it as a benchmark to develop our pipeline, paving the way for its application to a larger sample of AM CVn systems.\r\n\r\nMethods. We determined the binary parameters through photometric analysis and constrained the atmospheric parameters of the white dwarf accretor, including its effective temperature, surface gravity, and chemical abundances, by fitting the HST ultraviolet spectrum with synthetic spectral models. We then inferred the system’s formation channel by comparing the results with theoretical evolutionary models.\r\n\r\nResults. According to our measurements, the accretor’s effective temperature (Teff) is 23 300 ± 600 K and the surface gravity (log g) is 8.4 ± 0.3, which imply an accretor mass (MWD) of 0.86 ± 0.16 M⊙. We find a high nitrogen-to-carbon abundance ratio by mass of > 153.\r\n\r\nConclusions. The accretor is significantly hotter than previous estimates based on simplified blackbody fits to the spectral energy distribution, underscoring the importance of detailed spectral modelling for accurately determining system parameters. Our results show that ultraviolet spectroscopy is well suited to constraining the formation channels of AM CVn systems. Of the three proposed formation channels, the He-star channel can be excluded given the high nitrogen-to-carbon ratio. Our results are consistent with both the white dwarf and cataclysmic variable channels.","lang":"eng"}],"volume":706,"year":"2026","date_created":"2026-02-08T23:02:49Z","external_id":{"arxiv":["2512.04147"]},"oa_version":"Published Version","_id":"21160","publication":"Astronomy and Astrophysics","language":[{"iso":"eng"}],"PlanS_conform":"1","article_type":"original","title":"The evolutionary history of ultra-compact accreting binaries: I. Chemical abundances and the formation channel of the eclipsing AM CVn system ZTF J225237.05-051917.4 from HST spectroscopy","status":"public","scopus_import":"1","file":[{"creator":"dernst","file_id":"21227","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_name":"2026_AstronomyAstrophysics_Yu.pdf","checksum":"2faec710fd04f927aa43deb57e35c9b2","file_size":4020466,"success":1,"date_created":"2026-02-16T09:33:56Z","date_updated":"2026-02-16T09:33:56Z"}],"ddc":["520"],"OA_type":"diamond","date_updated":"2026-02-16T09:36:24Z","publication_status":"published","month":"02","author":[{"full_name":"Yu, W.","first_name":"W.","last_name":"Yu"},{"last_name":"Pala","first_name":"A. F.","full_name":"Pala, A. F."},{"first_name":"T.","full_name":"Kupfer, T.","last_name":"Kupfer"},{"first_name":"B. T.","full_name":"Gänsicke, B. T.","last_name":"Gänsicke"},{"last_name":"Koester","first_name":"D.","full_name":"Koester, D."},{"last_name":"Belloni","full_name":"Belloni, D.","first_name":"D."},{"full_name":"Wong, T. L.S.","first_name":"T. L.S.","last_name":"Wong"},{"last_name":"Schreiber","first_name":"M. R.","full_name":"Schreiber, M. R."},{"full_name":"van Roestel, Joannes C","first_name":"Joannes C","id":"4d122fc8-6083-11f0-87a5-97d68b860333","last_name":"van Roestel"},{"full_name":"Brown, A. J.","first_name":"A. J.","last_name":"Brown"},{"last_name":"Waagen","full_name":"Waagen, E. O.","first_name":"E. O."},{"full_name":"González-Carballo, J. L.","first_name":"J. L.","last_name":"González-Carballo"},{"last_name":"Bednarz","full_name":"Bednarz, S.","first_name":"S."},{"full_name":"Bernacki, K.","first_name":"K.","last_name":"Bernacki"},{"full_name":"De Martino, D.","first_name":"D.","last_name":"De Martino"},{"full_name":"Fernández Mañanes, E.","first_name":"E.","last_name":"Fernández Mañanes"},{"full_name":"González Farfán, R.","first_name":"R.","last_name":"González Farfán"},{"full_name":"Green, M. J.","first_name":"M. J.","last_name":"Green"},{"first_name":"P. J.","full_name":"Groot, P. J.","last_name":"Groot"},{"first_name":"F. J.","full_name":"Hambsch, F. J.","last_name":"Hambsch"},{"first_name":"C.","full_name":"Knigge, C.","last_name":"Knigge"},{"full_name":"Martin-Velasco, J. L.","first_name":"J. L.","last_name":"Martin-Velasco"},{"last_name":"Morales-Aimar","full_name":"Morales-Aimar, M.","first_name":"M."},{"last_name":"Myers","full_name":"Myers, G.","first_name":"G."},{"last_name":"Naves Nogues","full_name":"Naves Nogues, R.","first_name":"R."},{"last_name":"Poggiani","full_name":"Poggiani, R.","first_name":"R."},{"last_name":"Popowicz","full_name":"Popowicz, A.","first_name":"A."},{"last_name":"Ramsay","first_name":"G.","full_name":"Ramsay, G."},{"last_name":"Reina-Lorenz","first_name":"E.","full_name":"Reina-Lorenz, E."},{"full_name":"Rodríguez-Gil, P.","first_name":"P.","last_name":"Rodríguez-Gil"},{"last_name":"Salto-González","first_name":"J. L.","full_name":"Salto-González, J. L."},{"last_name":"Sion","first_name":"E. M.","full_name":"Sion, E. M."},{"last_name":"Steeghs","full_name":"Steeghs, D.","first_name":"D."},{"last_name":"Szkody","first_name":"P.","full_name":"Szkody, P."},{"last_name":"Toloza","first_name":"O.","full_name":"Toloza, O."},{"full_name":"Tovmassian, G.","first_name":"G.","last_name":"Tovmassian"}],"file_date_updated":"2026-02-16T09:33:56Z","type":"journal_article","oa":1,"doi":"10.1051/0004-6361/202557568","has_accepted_license":"1","acknowledgement":"We thank Lars Bildsten for valuable insights and discussions. We acknowledge with thanks the variable star observations from the\r\nAAVSO International Database contributed by observers worldwide and used in this research. We thank the members of the Spanish Observers of Supernovae\r\n(ObSN) group for their valuable photometric contributions. This research was\r\nsupported by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC 2121 “Quantum Universe”\r\n– 390833306. Co-funded by the European Union (ERC, CompactBINARIES,\r\n101078773). Views and opinions expressed are however those of the author(s)\r\nonly and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority\r\ncan be held responsible for them. DB acknowledges support from the São Paulo\r\nResearch Foundation (FAPESP), Brazil, Process Numbers #2024/03736-2 and\r\n#2025/00817-4. MRS is supported by Fondecyt (grant 1221059). MJG acknowledges support from the European Research Council through ERC Advanced\r\nGrant No. 101054731, from the National Aeronautics and Space Administration under grants 80NSSC24K0436, 80NSSC22K0479, and 80NSSC24K0380,\r\nand from the National Science Foundation under grant AST-2205736. PJG\r\nis supported by NRF SARChI grant 111692. PR-G acknowledges support by\r\nthe Agencia Estatal de Investigación del Ministerio de Ciencia e Innovación\r\n(MCIN/AEI) and the European Regional Development Fund (ERDF) under grant\r\nPID2021–124879NB–I00. DS is supported by the UK Science and Technology Facilities Council (STFC, grant numbers ST/T007184/1, ST/T003103/1,\r\nand ST/T000406/1). OT acknowledges Proyectos Internos USM 2025, PI-LII2025-03. GT was supported by grants IN109723 from the Programa de Apoyo a\r\nProyectos de Investigación e Innovación Tecnológica (PAPIIT). This project has\r\nreceived funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 101020057).","article_number":"A14","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"ista":"Yu W, Pala AF, Kupfer T, Gänsicke BT, Koester D, Belloni D, Wong TLS, Schreiber MR, van Roestel JC, Brown AJ, Waagen EO, González-Carballo JL, Bednarz S, Bernacki K, De Martino D, Fernández Mañanes E, González Farfán R, Green MJ, Groot PJ, Hambsch FJ, Knigge C, Martin-Velasco JL, Morales-Aimar M, Myers G, Naves Nogues R, Poggiani R, Popowicz A, Ramsay G, Reina-Lorenz E, Rodríguez-Gil P, Salto-González JL, Sion EM, Steeghs D, Szkody P, Toloza O, Tovmassian G. 2026. The evolutionary history of ultra-compact accreting binaries: I. Chemical abundances and the formation channel of the eclipsing AM CVn system ZTF J225237.05-051917.4 from HST spectroscopy. Astronomy and Astrophysics. 706, A14.","apa":"Yu, W., Pala, A. F., Kupfer, T., Gänsicke, B. T., Koester, D., Belloni, D., … Tovmassian, G. (2026). The evolutionary history of ultra-compact accreting binaries: I. Chemical abundances and the formation channel of the eclipsing AM CVn system ZTF J225237.05-051917.4 from HST spectroscopy. <i>Astronomy and Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/202557568\">https://doi.org/10.1051/0004-6361/202557568</a>","chicago":"Yu, W., A. F. Pala, T. Kupfer, B. T. Gänsicke, D. Koester, D. Belloni, T. L.S. Wong, et al. “The Evolutionary History of Ultra-Compact Accreting Binaries: I. Chemical Abundances and the Formation Channel of the Eclipsing AM CVn System ZTF J225237.05-051917.4 from HST Spectroscopy.” <i>Astronomy and Astrophysics</i>. EDP Sciences, 2026. <a href=\"https://doi.org/10.1051/0004-6361/202557568\">https://doi.org/10.1051/0004-6361/202557568</a>.","ieee":"W. Yu <i>et al.</i>, “The evolutionary history of ultra-compact accreting binaries: I. Chemical abundances and the formation channel of the eclipsing AM CVn system ZTF J225237.05-051917.4 from HST spectroscopy,” <i>Astronomy and Astrophysics</i>, vol. 706. EDP Sciences, 2026.","mla":"Yu, W., et al. “The Evolutionary History of Ultra-Compact Accreting Binaries: I. Chemical Abundances and the Formation Channel of the Eclipsing AM CVn System ZTF J225237.05-051917.4 from HST Spectroscopy.” <i>Astronomy and Astrophysics</i>, vol. 706, A14, EDP Sciences, 2026, doi:<a href=\"https://doi.org/10.1051/0004-6361/202557568\">10.1051/0004-6361/202557568</a>.","short":"W. Yu, A.F. Pala, T. Kupfer, B.T. Gänsicke, D. Koester, D. Belloni, T.L.S. Wong, M.R. Schreiber, J.C. van Roestel, A.J. Brown, E.O. Waagen, J.L. González-Carballo, S. Bednarz, K. Bernacki, D. De Martino, E. Fernández Mañanes, R. González Farfán, M.J. Green, P.J. Groot, F.J. Hambsch, C. Knigge, J.L. Martin-Velasco, M. Morales-Aimar, G. Myers, R. Naves Nogues, R. Poggiani, A. Popowicz, G. Ramsay, E. Reina-Lorenz, P. Rodríguez-Gil, J.L. Salto-González, E.M. Sion, D. Steeghs, P. Szkody, O. Toloza, G. Tovmassian, Astronomy and Astrophysics 706 (2026).","ama":"Yu W, Pala AF, Kupfer T, et al. The evolutionary history of ultra-compact accreting binaries: I. Chemical abundances and the formation channel of the eclipsing AM CVn system ZTF J225237.05-051917.4 from HST spectroscopy. <i>Astronomy and Astrophysics</i>. 2026;706. doi:<a href=\"https://doi.org/10.1051/0004-6361/202557568\">10.1051/0004-6361/202557568</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"IlCa"}],"publisher":"EDP Sciences","publication_identifier":{"issn":["0004-6361"],"eissn":["1432-0746"]},"article_processing_charge":"No","day":"01","arxiv":1,"quality_controlled":"1","date_published":"2026-02-01T00:00:00Z","OA_place":"publisher","intvolume":"       706"},{"language":[{"iso":"eng"}],"publication":"Proceedings of the Royal Society B Biological Sciences","_id":"21161","status":"public","file":[{"file_id":"21226","creator":"dernst","relation":"main_file","content_type":"application/pdf","access_level":"open_access","file_name":"2026_RoyalSocPubProceedingsB_Barata.pdf","checksum":"d76afebca0a6f112df0146ae2d929f36","file_size":2230841,"success":1,"date_created":"2026-02-16T09:26:02Z","date_updated":"2026-02-16T09:26:02Z"}],"scopus_import":"1","title":"Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster","article_type":"original","PlanS_conform":"1","publication_status":"published","date_updated":"2026-02-16T09:27:33Z","OA_type":"hybrid","ddc":["570"],"author":[{"full_name":"De Castro Barbosa Rodrigues Barata, Carolina","orcid":"0000-0003-1945-2245","first_name":"Carolina","last_name":"De Castro Barbosa Rodrigues Barata","id":"20565186-803f-11ed-ab7e-96a4ff7694ef"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso","first_name":"Beatriz","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz"}],"month":"01","abstract":[{"text":"In many species, sex-biased expression is widespread and thought to contribute to sexual dimorphism. While bulk RNA-sequencing has been instrumental in identifying strongly sex-biased genes, it lacks resolution to assess variation across cell-types and tissue compartments. Using single-nucleus expression data from the Fly Cell Atlas, we investigate sex differences in adult Drosophila melanogaster. We find that differences in cell-type composition between the sexes are not a major source of sex-bias, as for the vast majority of genes, the degree of sex-bias is similar regardless of whether sex differences in cell-type composition are controlled for or not. Our analysis confirms a deficit of X-linked male-biased genes in the body’s somatic tissues that is widespread across cell-types. We also find the excess of X-linked female-biased genes to be associated with nervous system cells in the head but with epithelial cells in the body’s somatic tissues, showing that single-nucleus data crucially resolves sex-bias at the cell-type level. We investigate dosage compensation (DC) across 15 tissues and 17 cell-types. We observe that it varies throughout the body. Surprisingly, we observe a lack of DC in a cluster of main cells within the male accessory glands. This result highlights the importance of understanding context-dependent DC.","lang":"eng"}],"year":"2026","volume":293,"project":[{"_id":"90ef7108-16d5-11f0-9cad-e6e116913473","name":"Does genetic drift set a limit on the adaptive evolution of sex-biased expression?","grant_number":"ESP 6331524"}],"external_id":{"pmid":["41592777"]},"date_created":"2026-02-08T23:02:49Z","oa_version":"Published Version","issue":"2063","publisher":"Royal Society of London","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"BeVi"}],"citation":{"short":"C. de Castro Barbosa Rodrigues Barata, B. Vicoso, Proceedings of the Royal Society B Biological Sciences 293 (2026).","ama":"de Castro Barbosa Rodrigues Barata C, Vicoso B. Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster. <i>Proceedings of the Royal Society B Biological Sciences</i>. 2026;293(2063). doi:<a href=\"https://doi.org/10.1098/rspb.2025.2471\">10.1098/rspb.2025.2471</a>","ista":"de Castro Barbosa Rodrigues Barata C, Vicoso B. 2026. Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster. Proceedings of the Royal Society B Biological Sciences. 293(2063), 20252471.","apa":"de Castro Barbosa Rodrigues Barata, C., &#38; Vicoso, B. (2026). Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster. <i>Proceedings of the Royal Society B Biological Sciences</i>. Royal Society of London. <a href=\"https://doi.org/10.1098/rspb.2025.2471\">https://doi.org/10.1098/rspb.2025.2471</a>","ieee":"C. de Castro Barbosa Rodrigues Barata and B. Vicoso, “Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster,” <i>Proceedings of the Royal Society B Biological Sciences</i>, vol. 293, no. 2063. Royal Society of London, 2026.","chicago":"Castro Barbosa Rodrigues Barata, Carolina de, and Beatriz Vicoso. “Single-Nucleus Resolution of Sex-Biased Expression and Dosage Compensation in Drosophila Melanogaster.” <i>Proceedings of the Royal Society B Biological Sciences</i>. Royal Society of London, 2026. <a href=\"https://doi.org/10.1098/rspb.2025.2471\">https://doi.org/10.1098/rspb.2025.2471</a>.","mla":"de Castro Barbosa Rodrigues Barata, Carolina, and Beatriz Vicoso. “Single-Nucleus Resolution of Sex-Biased Expression and Dosage Compensation in Drosophila Melanogaster.” <i>Proceedings of the Royal Society B Biological Sciences</i>, vol. 293, no. 2063, 20252471, Royal Society of London, 2026, doi:<a href=\"https://doi.org/10.1098/rspb.2025.2471\">10.1098/rspb.2025.2471</a>."},"article_processing_charge":"Yes (via OA deal)","publication_identifier":{"eissn":["1471-2954"]},"quality_controlled":"1","day":"28","OA_place":"publisher","intvolume":"       293","date_published":"2026-01-28T00:00:00Z","pmid":1,"type":"journal_article","file_date_updated":"2026-02-16T09:26:02Z","doi":"10.1098/rspb.2025.2471","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_number":"20252471","acknowledgement":"This work was partly funded by an Austrian Science Foundation FWF ESPRIT fellowship (10.55776/ESP6331524) to C.B. We would like to thank the Vicoso group for their invaluable input and discussions throughout this work. We thank Filip Ruzicka for his insightful comments on the manuscript. All computational resources were provided by the Scientific Computing Unit at ISTA. This research was also supported through resources provided by the Imaging & Optics Facility (IOF) at ISTA.","has_accepted_license":"1","corr_author":"1","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"}]},{"acknowledgement":"Part of this material is based upon work supported by the NSF National Center for Atmospheric Research, which is a major facility sponsored by the National Science Foundation under Cooperative Agreement No. 1852977. Casallas was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 101034413. E. D. Freitas thanks the support provided by the National Council for Scientific and Technological Development (CNPq, Process number 313210/2022–5). Silva gratefully acknowledges the financial support from the National Council for Scientific and Technological Development (CNPq), process number 140512/2021–7. P. Lichtig was supported by base funding from the National Commission for Atomic Energy (CNEA, Arg.) and by NSF NCAR. R.Y. Ynoue thanks the support provided by the National Council for Scientific and Technological Development (CNPq, Process number 406728/2022–4). M. A. Franco thanks the support provided by the National Council for Scientific and Technological Development (CNPq, Process number 407752/2023–4). G. M. Pereira thanks the support by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP; Process numbers 2018/07848–9, 2016/18438–0, and 2019/01316–80) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; Process number 88887.103225/2025–00). M.F. Andrade thanks the support by FAPESP (Process number 2016/18438–0) and CNPQ (Klimapolis INCT).","has_accepted_license":"1","article_number":"5c08400","doi":"10.1021/acs.est.5c08400","type":"journal_article","pmid":1,"date_published":"2026-02-04T00:00:00Z","day":"04","quality_controlled":"1","publication_identifier":{"issn":["0013-936X"],"eissn":["1520-5851"]},"article_processing_charge":"No","publisher":"American Chemical Society","citation":{"mla":"Ibarra-Espinosa, Sergio, et al. “A Century of Vehicular Emissions in Brazil: Unveiling the Impacts of Unique Fuel Mix on Air Quality.” <i>Environmental Science &#38;amp; Technology</i>, 5c08400, American Chemical Society, 2026, doi:<a href=\"https://doi.org/10.1021/acs.est.5c08400\">10.1021/acs.est.5c08400</a>.","ista":"Ibarra-Espinosa S, Dias de Freitas E, Gaubert B, Lichtig P, Ropkins K, da Silva I, Martins Pereira G, Schuch D, Nascimento J, Hoinaski L, Martins LD, Gavidia-Calderón M, Vara-Vela A, Toledo de Almeida Albuquerque T, Ynoue RY, Diez S, Mera Z, Casallas Garcia A, Vallejo F, Diaz V, Pedruzzi R, Abrutzky R, Franco MA, Huneeus N, Jorquera H, Belalcázar-Cerón LC, Rojas NY, de Fatima Andrade M, Emmons L, Brasseur G. 2026. A century of vehicular emissions in Brazil: Unveiling the impacts of unique fuel mix on air quality. Environmental Science &#38;amp; Technology., 5c08400.","apa":"Ibarra-Espinosa, S., Dias de Freitas, E., Gaubert, B., Lichtig, P., Ropkins, K., da Silva, I., … Brasseur, G. (2026). A century of vehicular emissions in Brazil: Unveiling the impacts of unique fuel mix on air quality. <i>Environmental Science &#38;amp; Technology</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.est.5c08400\">https://doi.org/10.1021/acs.est.5c08400</a>","ieee":"S. Ibarra-Espinosa <i>et al.</i>, “A century of vehicular emissions in Brazil: Unveiling the impacts of unique fuel mix on air quality,” <i>Environmental Science &#38;amp; Technology</i>. American Chemical Society, 2026.","chicago":"Ibarra-Espinosa, Sergio, Edmilson Dias de Freitas, Benjamin Gaubert, Pablo Lichtig, Karl Ropkins, Iara da Silva, Guilherme Martins Pereira, et al. “A Century of Vehicular Emissions in Brazil: Unveiling the Impacts of Unique Fuel Mix on Air Quality.” <i>Environmental Science &#38;amp; Technology</i>. American Chemical Society, 2026. <a href=\"https://doi.org/10.1021/acs.est.5c08400\">https://doi.org/10.1021/acs.est.5c08400</a>.","ama":"Ibarra-Espinosa S, Dias de Freitas E, Gaubert B, et al. A century of vehicular emissions in Brazil: Unveiling the impacts of unique fuel mix on air quality. <i>Environmental Science &#38;amp; Technology</i>. 2026. doi:<a href=\"https://doi.org/10.1021/acs.est.5c08400\">10.1021/acs.est.5c08400</a>","short":"S. Ibarra-Espinosa, E. Dias de Freitas, B. Gaubert, P. Lichtig, K. Ropkins, I. da Silva, G. Martins Pereira, D. Schuch, J. Nascimento, L. Hoinaski, L.D. Martins, M. Gavidia-Calderón, A. Vara-Vela, T. Toledo de Almeida Albuquerque, R.Y. Ynoue, S. Diez, Z. Mera, A. Casallas Garcia, F. Vallejo, V. Diaz, R. Pedruzzi, R. Abrutzky, M.A. Franco, N. Huneeus, H. Jorquera, L.C. Belalcázar-Cerón, N.Y. Rojas, M. de Fatima Andrade, L. Emmons, G. Brasseur, Environmental Science &#38;amp; Technology (2026)."},"department":[{"_id":"CaMu"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"None","date_created":"2026-02-09T06:54:10Z","external_id":{"pmid":["41636708"]},"year":"2026","project":[{"call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413"}],"abstract":[{"lang":"eng","text":"Global emission inventories often fail to capture the complexities of vehicular pollution in regions with unique fuel mixes, such as Brazil’s extensive biofuel use, leading to significant uncertainties in atmospheric modeling. This study presents a century-long (1960–2100) bottom-up vehicular emission inventory for Brazil, leveraging locally derived emission factors. Our estimates reveal substantial discrepancies in magnitude, timing, and speciation of non-CO2 pollutants (CO, NMHC, PM2.5) compared to leading global inventories (EDGAR, CEDS, CAMS), highlighting critical inaccuracies in widely used data sets. More critically, future projections under Shared Socioeconomic Pathways (SSPs) uncover a novel positive feedback mechanism: rising temperatures significantly enhance vehicular evaporative nonmethane hydrocarbon (NMHC) emissions. This temperature-dependent increase and subsequent NMHC oxidation to CO2 suggest an overlooked pathway that could amplify climate warming and air pollution globally, particularly after a breakpoint around 2050 (p < 0.05). While historical emissions peaked in the 1990s–2000s, nonexhaust PM becomes increasingly important. Air quality simulations using our inventory in the MUSICA model show good regional PM2.5 agreement but highlight challenges in resolving local primary pollutant peaks. This comprehensive inventory provides crucial data for Brazil and uncovers globally relevant climate–chemistry interactions, urging a re-evaluation of regional specificities in global emission assessments."}],"ec_funded":1,"month":"02","author":[{"full_name":"Ibarra-Espinosa, Sergio","first_name":"Sergio","last_name":"Ibarra-Espinosa"},{"full_name":"Dias de Freitas, Edmilson","first_name":"Edmilson","last_name":"Dias de Freitas"},{"full_name":"Gaubert, Benjamin","first_name":"Benjamin","last_name":"Gaubert"},{"last_name":"Lichtig","full_name":"Lichtig, Pablo","first_name":"Pablo"},{"first_name":"Karl","full_name":"Ropkins, Karl","last_name":"Ropkins"},{"last_name":"da Silva","full_name":"da Silva, Iara","first_name":"Iara"},{"last_name":"Martins Pereira","first_name":"Guilherme","full_name":"Martins Pereira, Guilherme"},{"full_name":"Schuch, Daniel","first_name":"Daniel","last_name":"Schuch"},{"last_name":"Nascimento","first_name":"Janaina","full_name":"Nascimento, Janaina"},{"full_name":"Hoinaski, Leonardo","first_name":"Leonardo","last_name":"Hoinaski"},{"first_name":"Leila Droprinchinski","full_name":"Martins, Leila Droprinchinski","last_name":"Martins"},{"last_name":"Gavidia-Calderón","first_name":"Mario","full_name":"Gavidia-Calderón, Mario"},{"last_name":"Vara-Vela","first_name":"Angel","full_name":"Vara-Vela, Angel"},{"last_name":"Toledo de Almeida Albuquerque","first_name":"Taciana","full_name":"Toledo de Almeida Albuquerque, Taciana"},{"last_name":"Ynoue","first_name":"Rita Yuri","full_name":"Ynoue, Rita Yuri"},{"full_name":"Diez, Sebastian","first_name":"Sebastian","last_name":"Diez"},{"first_name":"Zamir","full_name":"Mera, Zamir","last_name":"Mera"},{"orcid":"0000-0002-1988-5035","first_name":"Alejandro","full_name":"Casallas Garcia, Alejandro","last_name":"Casallas Garcia","id":"92081129-2d75-11ef-a48d-b04dd7a2385a"},{"last_name":"Vallejo","full_name":"Vallejo, Fidel","first_name":"Fidel"},{"full_name":"Diaz, Valeria","first_name":"Valeria","last_name":"Diaz"},{"full_name":"Pedruzzi, Rizzieri","first_name":"Rizzieri","last_name":"Pedruzzi"},{"full_name":"Abrutzky, Rosana","first_name":"Rosana","last_name":"Abrutzky"},{"first_name":"Marco A.","full_name":"Franco, Marco A.","last_name":"Franco"},{"last_name":"Huneeus","full_name":"Huneeus, Nicolas","first_name":"Nicolas"},{"first_name":"Hector","full_name":"Jorquera, Hector","last_name":"Jorquera"},{"first_name":"Luis Carlos","full_name":"Belalcázar-Cerón, Luis Carlos","last_name":"Belalcázar-Cerón"},{"first_name":"Néstor Y.","full_name":"Rojas, Néstor Y.","last_name":"Rojas"},{"full_name":"de Fatima Andrade, Maria","first_name":"Maria","last_name":"de Fatima Andrade"},{"first_name":"Louisa","full_name":"Emmons, Louisa","last_name":"Emmons"},{"last_name":"Brasseur","full_name":"Brasseur, Guy","first_name":"Guy"}],"ddc":["550"],"publication_status":"epub_ahead","date_updated":"2026-02-16T10:33:07Z","article_type":"original","scopus_import":"1","status":"public","title":"A century of vehicular emissions in Brazil: Unveiling the impacts of unique fuel mix on air quality","_id":"21164","language":[{"iso":"eng"}],"publication":"Environmental Science &amp; Technology"},{"oa_version":"Preprint","tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"acknowledgement":"We thank Dr. Wenjie Liu for providing critical feedback on the manuscript. We also thank Dr.\r\nPat Pramoonjago at the Biorepository and Tissue Research Facility, and Hope Davis at the\r\nvivarium for their assistance on the project. These Core Facilities are supported by UVA Cancer\r\nCenter grant #P30-CA044579. We are grateful to Dr. Jonathan A. Epstein for providing the\r\nNf1GRD/+ mouse strain (https://pubmed.ncbi.nlm.nih.gov/26460546/). This work was partly\r\nsupported by the National Institute of Neurological Diseases and Stroke R21 NS125479-01A1\r\n(H.Z.), American Cancer Society Institutional Research Grant to the University of Virginia\r\n(Y.J.), the National Natural Science Foundation of China #82072787 (M.Y.), the National\r\nCancer Institute U54 CA238114 (F.W.), U01 CA284193 (K.M.N.), and U54 CA274499 (K.A.J.,\r\nM.F-S.), the National institute of General Medical Sciences R35 GM133404 (M.F-S.), the Dr.\r\nMiriam and Sheldon G. Adelson Medical Research Foundation (H.I.K., S.A.G.), the National\r\nCenter for Advancing Translational Sciences KL2TR001882 (K.S.P.), Tower Cancer Career Development Grant (K.S.P.), McKnight Neurobiology of Brain Disorders Grant (K.S.P.). The\r\ncontent is solely the responsibility of the authors and does not necessarily represent the official\r\nviews of the National Institutes of Health. Illustrations in this manuscript were created with\r\nBioRender (BioRender.com).","has_accepted_license":"1","date_created":"2026-02-10T12:55:55Z","doi":"10.64898/2026.01.15.699808","year":"2026","oa":1,"type":"preprint","main_file_link":[{"open_access":"1","url":"https://doi.org/10.64898/2026.01.15.699808"}],"abstract":[{"lang":"eng","text":"Malignant glioma is incurable. Using a mouse genetic mosaic system to generate sporadic Trp53,Nf1-null OPCs, we previously identified oligodendrocyte precursor cell (OPC) as a cell-of-origin of glioma. Here, we report that pre-malignant Trp53,Nf1-null OPCs outcompete wildtype counterparts during their expansion. Blocking competition by mutating/strengthening wildtype OPCs impeded both pre-malignant progression and malignant expansion of glioma.\r\n\r\n“In-tissue” phosphoproteomic profiling revealed an enrichment of phosphopeptides related to RNA splicing and protein translation at the peak of cell competition, suggesting that competitiveness may stem from unique protein species. Among candidates was mTORC1, whose pharmacological inhibition or genetic disruption resulted in a loss of competitiveness in our mouse model. Finally, analysis of patient biopsies and interrogating the role of individual gliomagenic mutations in OPC competition supported its relevance in human gliomas. Together, these findings identified the driving role of competitive interactions among OPCs in gliomagenesis, and suggest unconventional therapeutic strategies to target this process."}],"month":"01","author":[{"last_name":"Jiang","full_name":"Jiang, Ying","first_name":"Ying"},{"full_name":"Ahn, Ryuhjin","first_name":"Ryuhjin","last_name":"Ahn"},{"first_name":"Arthur","full_name":"Huang, Arthur","last_name":"Huang"},{"last_name":"Gonzalez","first_name":"Phillippe P.","full_name":"Gonzalez, Phillippe P."},{"first_name":"Jungeun","full_name":"Kim, Jungeun","last_name":"Kim"},{"last_name":"Zhang","first_name":"Guoxin","full_name":"Zhang, Guoxin"},{"last_name":"Liu","full_name":"Liu, Zihao","first_name":"Zihao"},{"first_name":"Zhenqiang","full_name":"He, Zhenqiang","last_name":"He"},{"last_name":"Dudley","first_name":"Lindsey","full_name":"Dudley, Lindsey"},{"last_name":"Patel","first_name":"Kunal S.","full_name":"Patel, Kunal S."},{"last_name":"Dzhivhuho","first_name":"Godfrey A.","full_name":"Dzhivhuho, Godfrey A."},{"full_name":"Crowl, Sam","first_name":"Sam","last_name":"Crowl"},{"first_name":"Piotr","full_name":"Przanowski, Piotr","last_name":"Przanowski"},{"full_name":"Camacho, Luisa Quesada","first_name":"Luisa Quesada","last_name":"Camacho"},{"last_name":"Hao","full_name":"Hao, Sijie","first_name":"Sijie"},{"first_name":"Jianhao","full_name":"Zeng, Jianhao","last_name":"Zeng"},{"full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","first_name":"Simon","last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Mohammad","full_name":"Fallahi-Sichani, Mohammad","last_name":"Fallahi-Sichani"},{"last_name":"Janes","first_name":"Kevin A.","full_name":"Janes, Kevin A."},{"full_name":"Naegle, Kristen M.","first_name":"Kristen M.","last_name":"Naegle"},{"last_name":"Hammarskjold","full_name":"Hammarskjold, Marie-Louise","first_name":"Marie-Louise"},{"last_name":"Goldman","full_name":"Goldman, Steven A.","first_name":"Steven A."},{"full_name":"Kornblum, Harley I.","first_name":"Harley I.","last_name":"Kornblum"},{"full_name":"Yao, Maojin","first_name":"Maojin","last_name":"Yao"},{"last_name":"White","first_name":"Forest","full_name":"White, Forest"},{"last_name":"Zong","first_name":"Hui","full_name":"Zong, Hui"}],"OA_place":"repository","date_published":"2026-01-16T00:00:00Z","publication_status":"published","date_updated":"2026-02-16T10:12:42Z","day":"16","ddc":["570"],"OA_type":"green","article_processing_charge":"No","status":"public","title":"Critical role of cell competition in gliomagenesis","language":[{"iso":"eng"}],"publication":"bioRxiv","citation":{"short":"Y. Jiang, R. Ahn, A. Huang, P.P. Gonzalez, J. Kim, G. Zhang, Z. Liu, Z. He, L. Dudley, K.S. Patel, G.A. Dzhivhuho, S. Crowl, P. Przanowski, L.Q. Camacho, S. Hao, J. Zeng, S. Hippenmeyer, M. Fallahi-Sichani, K.A. Janes, K.M. Naegle, M.-L. Hammarskjold, S.A. Goldman, H.I. Kornblum, M. Yao, F. White, H. Zong, BioRxiv (2026).","ama":"Jiang Y, Ahn R, Huang A, et al. Critical role of cell competition in gliomagenesis. <i>bioRxiv</i>. 2026. doi:<a href=\"https://doi.org/10.64898/2026.01.15.699808\">10.64898/2026.01.15.699808</a>","ista":"Jiang Y, Ahn R, Huang A, Gonzalez PP, Kim J, Zhang G, Liu Z, He Z, Dudley L, Patel KS, Dzhivhuho GA, Crowl S, Przanowski P, Camacho LQ, Hao S, Zeng J, Hippenmeyer S, Fallahi-Sichani M, Janes KA, Naegle KM, Hammarskjold M-L, Goldman SA, Kornblum HI, Yao M, White F, Zong H. 2026. Critical role of cell competition in gliomagenesis. bioRxiv, <a href=\"https://doi.org/10.64898/2026.01.15.699808\">10.64898/2026.01.15.699808</a>.","apa":"Jiang, Y., Ahn, R., Huang, A., Gonzalez, P. P., Kim, J., Zhang, G., … Zong, H. (2026). Critical role of cell competition in gliomagenesis. <i>bioRxiv</i>. <a href=\"https://doi.org/10.64898/2026.01.15.699808\">https://doi.org/10.64898/2026.01.15.699808</a>","chicago":"Jiang, Ying, Ryuhjin Ahn, Arthur Huang, Phillippe P. Gonzalez, Jungeun Kim, Guoxin Zhang, Zihao Liu, et al. “Critical Role of Cell Competition in Gliomagenesis.” <i>BioRxiv</i>, 2026. <a href=\"https://doi.org/10.64898/2026.01.15.699808\">https://doi.org/10.64898/2026.01.15.699808</a>.","ieee":"Y. Jiang <i>et al.</i>, “Critical role of cell competition in gliomagenesis,” <i>bioRxiv</i>. 2026.","mla":"Jiang, Ying, et al. “Critical Role of Cell Competition in Gliomagenesis.” <i>BioRxiv</i>, 2026, doi:<a href=\"https://doi.org/10.64898/2026.01.15.699808\">10.64898/2026.01.15.699808</a>."},"_id":"21212","department":[{"_id":"SiHi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"publication":"Quarterly Journal of the Royal Meteorological Society","language":[{"iso":"eng"}],"_id":"21217","title":"Moisture and wind effects of Rossby waves on Western Pacific Intertropical Convergence Zone breakdown events","status":"public","scopus_import":"1","article_type":"original","date_updated":"2026-02-16T10:19:52Z","publication_status":"epub_ahead","OA_type":"hybrid","ddc":["550"],"author":[{"last_name":"Casallas Garcia","id":"92081129-2d75-11ef-a48d-b04dd7a2385a","orcid":"0000-0002-1988-5035","first_name":"Alejandro","full_name":"Casallas Garcia, Alejandro"},{"last_name":"Mark Tompkins","full_name":"Mark Tompkins, Adrian","first_name":"Adrian"},{"orcid":"0000-0001-5836-5350","first_name":"Caroline J","full_name":"Muller, Caroline J","last_name":"Muller","id":"f978ccb0-3f7f-11eb-b193-b0e2bd13182b"}],"month":"02","abstract":[{"lang":"eng","text":"This study investigates the mechanisms driving clustered convection and the breakdown of the Intertropical Convergence Zone (ITCZ) over the Western Pacific Warm Pool using high‐resolution cloud‐resolving simulations and machine‐learning sensitivity experiments. Results show that ITCZ breakdown episodes, marked by spatially homogeneous convection and weakened meridional moisture gradients, are triggered primarily by anomalous moisture advection linked to the equatorial Rossby‐wave activity. While large‐scale moisture advection regulates the background convective state strongly, it is the surface and low‐level meridional winds that dominate transitions between clustered and random convection. Simulations demonstrate that moisture alone can sustain convective clustering, but breakdown episodes are more persistent and widespread when coupled with southerly meridional advection. These findings confirm that wave‐driven advection acts as a regulatory mechanism, periodically disrupting convective clustering and reshaping the meridional moisture gradient. This modulation of organization by wave‐induced breakdown events is critical for understanding tropical convection variability and its implications for the climate system."}],"ec_funded":1,"project":[{"grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program"},{"call_identifier":"H2020","name":"Organization of CLoUdS, and implications of Tropical  cyclones and for the Energetics of the tropics, in current and waRming climate","_id":"629205d8-2b32-11ec-9570-e1356ff73576","grant_number":"805041"}],"year":"2026","date_created":"2026-02-12T10:13:02Z","oa_version":"Published Version","department":[{"_id":"CaMu"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"A. Casallas Garcia, A. Mark Tompkins, C.J. Muller, Quarterly Journal of the Royal Meteorological Society (2026).","ama":"Casallas Garcia A, Mark Tompkins A, Muller CJ. Moisture and wind effects of Rossby waves on Western Pacific Intertropical Convergence Zone breakdown events. <i>Quarterly Journal of the Royal Meteorological Society</i>. 2026. doi:<a href=\"https://doi.org/10.1002/qj.70131\">10.1002/qj.70131</a>","apa":"Casallas Garcia, A., Mark Tompkins, A., &#38; Muller, C. J. (2026). Moisture and wind effects of Rossby waves on Western Pacific Intertropical Convergence Zone breakdown events. <i>Quarterly Journal of the Royal Meteorological Society</i>. Wiley. <a href=\"https://doi.org/10.1002/qj.70131\">https://doi.org/10.1002/qj.70131</a>","chicago":"Casallas Garcia, Alejandro, Adrian Mark Tompkins, and Caroline J Muller. “Moisture and Wind Effects of Rossby Waves on Western Pacific Intertropical Convergence Zone Breakdown Events.” <i>Quarterly Journal of the Royal Meteorological Society</i>. Wiley, 2026. <a href=\"https://doi.org/10.1002/qj.70131\">https://doi.org/10.1002/qj.70131</a>.","ieee":"A. Casallas Garcia, A. Mark Tompkins, and C. J. Muller, “Moisture and wind effects of Rossby waves on Western Pacific Intertropical Convergence Zone breakdown events,” <i>Quarterly Journal of the Royal Meteorological Society</i>. Wiley, 2026.","ista":"Casallas Garcia A, Mark Tompkins A, Muller CJ. 2026. Moisture and wind effects of Rossby waves on Western Pacific Intertropical Convergence Zone breakdown events. Quarterly Journal of the Royal Meteorological Society., e70131.","mla":"Casallas Garcia, Alejandro, et al. “Moisture and Wind Effects of Rossby Waves on Western Pacific Intertropical Convergence Zone Breakdown Events.” <i>Quarterly Journal of the Royal Meteorological Society</i>, e70131, Wiley, 2026, doi:<a href=\"https://doi.org/10.1002/qj.70131\">10.1002/qj.70131</a>."},"publisher":"Wiley","article_processing_charge":"Yes (via OA deal)","publication_identifier":{"issn":["0035-9009"],"eissn":["1477-870X"]},"quality_controlled":"1","day":"12","OA_place":"publisher","date_published":"2026-02-12T00:00:00Z","type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1002/qj.70131","open_access":"1"}],"doi":"10.1002/qj.70131","oa":1,"article_number":"e70131","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"has_accepted_license":"1","acknowledgement":"This article is based on chapter 5 of the PhD thesis of A. Casallas. The authors thank Graziano Giuliani for discussions on the boundary-condition experiments. A. Casallas was supported by a PhD fellowship awarded by the Abdus Salam International Centre for Theoretical Physics. A. Casallas also acknowledges support by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 101034413. C. Muller acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (Project CLUSTER, Grant Agreement No. 805041). The authors gratefully acknowledge Daniel Hernández-Deckers, Lokahith Agasthya, Chris Holloway, and Paolina Cerlini for their valuable feedback and insightful discussions. They are especially thankful to Bety Pechacova for suggesting the use of SHAP to complement their analysis. They also thank the two anonymous reviewers for their constructive comments, which improved the quality and clarity of the article significantly. Open Access funding provided by Institute of Science and Technology Austria/KEMÖ.","corr_author":"1"}]
