[{"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","issue":"44","article_number":"abq1263","citation":{"ama":"Amberg N, Pauler F, Streicher C, Hippenmeyer S. Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression. Science Advances. 2022;8(44). doi:10.1126/sciadv.abq1263","short":"N. Amberg, F. Pauler, C. Streicher, S. Hippenmeyer, Science Advances 8 (2022).","mla":"Amberg, Nicole, et al. “Tissue-Wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression.” Science Advances, vol. 8, no. 44, abq1263, American Association for the Advancement of Science, 2022, doi:10.1126/sciadv.abq1263.","ista":"Amberg N, Pauler F, Streicher C, Hippenmeyer S. 2022. Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression. Science Advances. 8(44), abq1263.","chicago":"Amberg, Nicole, Florian Pauler, Carmen Streicher, and Simon Hippenmeyer. “Tissue-Wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression.” Science Advances. American Association for the Advancement of Science, 2022. https://doi.org/10.1126/sciadv.abq1263.","ieee":"N. Amberg, F. Pauler, C. Streicher, and S. Hippenmeyer, “Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression,” Science Advances, vol. 8, no. 44. American Association for the Advancement of Science, 2022.","apa":"Amberg, N., Pauler, F., Streicher, C., & Hippenmeyer, S. (2022). Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression. Science Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.abq1263"},"abstract":[{"text":"The generation of a correctly-sized cerebral cortex with all-embracing neuronal and glial cell-type diversity critically depends on faithful radial glial progenitor (RGP) cell proliferation/differentiation programs. Temporal RGP lineage progression is regulated by Polycomb Repressive Complex 2 (PRC2) and loss of PRC2 activity results in severe neurogenesis defects and microcephaly. How PRC2-dependent gene expression instructs RGP lineage progression is unknown. Here we utilize Mosaic Analysis with Double Markers (MADM)-based single cell technology and demonstrate that PRC2 is not cell-autonomously required in neurogenic RGPs but rather acts at the global tissue-wide level. Conversely, cortical astrocyte production and maturation is cell-autonomously controlled by PRC2-dependent transcriptional regulation. We thus reveal highly distinct and sequential PRC2 functions in RGP lineage progression that are dependent on complex interplays between intrinsic and tissue-wide properties. In a broader context our results imply a critical role for the genetic and cellular niche environment in neural stem cell behavior.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2025-09-09T14:30:38Z","type":"journal_article","volume":8,"oa":1,"project":[{"name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","_id":"260018B0-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"call_identifier":"FWF","_id":"268F8446-B435-11E9-9278-68D0E5697425","grant_number":"T01031","name":"Role of Eed in neural stem cell lineage progression"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","related_material":{"link":[{"url":"https://ista.ac.at/en/news/whole-tissue-shapes-brain-development/","description":"News on ISTA website","relation":"press_release"}]},"day":"01","publisher":"American Association for the Advancement of Science","_id":"11336","article_type":"original","title":"Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"},{"_id":"LifeSc"}],"quality_controlled":"1","scopus_import":"1","file_date_updated":"2023-03-21T14:18:10Z","oa_version":"Published Version","external_id":{"isi":["000918406800019"],"pmid":["36322669"]},"doi":"10.1126/sciadv.abq1263","ddc":["570"],"file":[{"file_id":"12742","creator":"patrickd","content_type":"application/pdf","file_size":2973998,"success":1,"checksum":"0117023e188542082ca6693cf39e7f03","file_name":"sciadv.abq1263.pdf","access_level":"open_access","date_updated":"2023-03-21T14:18:10Z","date_created":"2023-03-21T14:18:10Z","relation":"main_file"}],"pmid":1,"publication":"Science Advances","acknowledgement":"We thank A. Heger (IST Austria Preclinical Facility), A. Sommer and C. Czepe (VBCF GmbH, NGS Unit) and S. Gharagozlou for technical support. This research was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Imaging & Optics Facility (IOF), Lab Support Facility (LSF), and Preclinical Facility (PCF). N.A. received funding from the FWF Firnberg-Programm (T 1031). The work was supported by IST institutional funds and by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 725780 LinPro) to S.H.","article_processing_charge":"No","ec_funded":1,"date_published":"2022-11-01T00:00:00Z","corr_author":"1","department":[{"_id":"SiHi"}],"publication_status":"published","author":[{"id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","full_name":"Amberg, Nicole","orcid":"0000-0002-3183-8207","last_name":"Amberg","first_name":"Nicole"},{"orcid":"0000-0002-7462-0048","full_name":"Pauler, Florian","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","first_name":"Florian","last_name":"Pauler"},{"full_name":"Streicher, Carmen","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","last_name":"Streicher","first_name":"Carmen"},{"orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon","first_name":"Simon","last_name":"Hippenmeyer"}],"intvolume":" 8","publication_identifier":{"issn":["2375-2548"]},"date_created":"2022-04-26T15:04:50Z","isi":1,"status":"public","month":"11","year":"2022"},{"day":"15","publisher":"American Physical Society","article_type":"original","_id":"11337","date_updated":"2025-04-14T07:43:57Z","language":[{"iso":"eng"}],"abstract":[{"text":"Nonanalytic points in the return probability of a quantum state as a function of time, known as dynamical quantum phase transitions (DQPTs), have received great attention in recent years, but the understanding of their mechanism is still incomplete. In our recent work [Phys. Rev. Lett. 126, 040602 (2021)], we demonstrated that one-dimensional DQPTs can be produced by two distinct mechanisms, namely semiclassical precession and entanglement generation, leading to the definition of precession (pDQPTs) and entanglement (eDQPTs) dynamical quantum phase transitions. In this manuscript, we extend and investigate the notion of p- and eDQPTs in two-dimensional systems by considering semi-infinite ladders of varying width. For square lattices, we find that pDQPTs and eDQPTs persist and are characterized by similar phenomenology as in 1D: pDQPTs are associated with a magnetization sign change and a wide entanglement gap, while eDQPTs correspond to suppressed local observables and avoided crossings in the entanglement spectrum. However, DQPTs show higher sensitivity to the ladder width and other details, challenging the extrapolation to the thermodynamic limit especially for eDQPTs. Moving to honeycomb lattices, we also demonstrate that lattices with an odd number of nearest neighbors give rise to phenomenologies beyond the one-dimensional classification.","lang":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","project":[{"call_identifier":"H2020","grant_number":"850899","_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control"},{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"}],"oa":1,"type":"journal_article","volume":105,"article_number":"165149","citation":{"ama":"De Nicola S, Michailidis A, Serbyn M. Entanglement and precession in two-dimensional dynamical quantum phase transitions. Physical Review B. 2022;105. doi:10.1103/PhysRevB.105.165149","short":"S. De Nicola, A. Michailidis, M. Serbyn, Physical Review B 105 (2022).","mla":"De Nicola, Stefano, et al. “Entanglement and Precession in Two-Dimensional Dynamical Quantum Phase Transitions.” Physical Review B, vol. 105, 165149, American Physical Society, 2022, doi:10.1103/PhysRevB.105.165149.","ista":"De Nicola S, Michailidis A, Serbyn M. 2022. Entanglement and precession in two-dimensional dynamical quantum phase transitions. Physical Review B. 105, 165149.","ieee":"S. De Nicola, A. Michailidis, and M. Serbyn, “Entanglement and precession in two-dimensional dynamical quantum phase transitions,” Physical Review B, vol. 105. American Physical Society, 2022.","chicago":"De Nicola, Stefano, Alexios Michailidis, and Maksym Serbyn. “Entanglement and Precession in Two-Dimensional Dynamical Quantum Phase Transitions.” Physical Review B. American Physical Society, 2022. https://doi.org/10.1103/PhysRevB.105.165149.","apa":"De Nicola, S., Michailidis, A., & Serbyn, M. (2022). Entanglement and precession in two-dimensional dynamical quantum phase transitions. Physical Review B. American Physical Society. https://doi.org/10.1103/PhysRevB.105.165149"},"arxiv":1,"isi":1,"date_created":"2022-04-28T08:06:10Z","publication_identifier":{"issn":["2469-9950"],"eisbn":["2469-9969"]},"intvolume":" 105","author":[{"orcid":"0000-0002-4842-6671","full_name":"De Nicola, Stefano","id":"42832B76-F248-11E8-B48F-1D18A9856A87","first_name":"Stefano","last_name":"De Nicola"},{"orcid":"0000-0002-8443-1064","full_name":"Michailidis, Alexios","id":"36EBAD38-F248-11E8-B48F-1D18A9856A87","first_name":"Alexios","last_name":"Michailidis"},{"first_name":"Maksym","last_name":"Serbyn","orcid":"0000-0002-2399-5827","full_name":"Serbyn, Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87"}],"year":"2022","month":"04","status":"public","corr_author":"1","date_published":"2022-04-15T00:00:00Z","main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2112.11273"}],"ec_funded":1,"publication_status":"published","department":[{"_id":"MaSe"}],"acknowledgement":"We acknowledge support by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 850899).\r\nS.D.N. also acknowledges funding from the Institute of Science and Technology (IST) Austria, and from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement No. 754411.","publication":"Physical Review B","article_processing_charge":"No","scopus_import":"1","quality_controlled":"1","title":"Entanglement and precession in two-dimensional dynamical quantum phase transitions","doi":"10.1103/PhysRevB.105.165149","oa_version":"Preprint","external_id":{"isi":["000806812400004"],"arxiv":["2112.11273"]}},{"citation":{"mla":"Glover, Georgina, et al. “Nutrient and Salt Depletion Synergistically Boosts Glucose Metabolism in Individual Escherichia Coli Cells.” Communications Biology, vol. 5, 385, Springer Nature, 2022, doi:10.1038/s42003-022-03336-6.","short":"G. Glover, M. Voliotis, U. Łapińska, B.M. Invergo, D. Soanes, P. O’Neill, K. Moore, N. Nikolic, P. Petrov, D.S. Milner, S. Roy, K. Heesom, T.A. Richards, K. Tsaneva-Atanasova, S. Pagliara, Communications Biology 5 (2022).","ama":"Glover G, Voliotis M, Łapińska U, et al. Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells. Communications Biology. 2022;5. doi:10.1038/s42003-022-03336-6","apa":"Glover, G., Voliotis, M., Łapińska, U., Invergo, B. M., Soanes, D., O’Neill, P., … Pagliara, S. (2022). Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells. Communications Biology. Springer Nature. https://doi.org/10.1038/s42003-022-03336-6","ieee":"G. Glover et al., “Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells,” Communications Biology, vol. 5. Springer Nature, 2022.","chicago":"Glover, Georgina, Margaritis Voliotis, Urszula Łapińska, Brandon M. Invergo, Darren Soanes, Paul O’Neill, Karen Moore, et al. “Nutrient and Salt Depletion Synergistically Boosts Glucose Metabolism in Individual Escherichia Coli Cells.” Communications Biology. Springer Nature, 2022. https://doi.org/10.1038/s42003-022-03336-6.","ista":"Glover G, Voliotis M, Łapińska U, Invergo BM, Soanes D, O’Neill P, Moore K, Nikolic N, Petrov P, Milner DS, Roy S, Heesom K, Richards TA, Tsaneva-Atanasova K, Pagliara S. 2022. Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells. Communications Biology. 5, 385."},"article_number":"385","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","type":"journal_article","volume":5,"date_updated":"2023-08-03T06:45:26Z","abstract":[{"text":"The interaction between a cell and its environment shapes fundamental intracellular processes such as cellular metabolism. In most cases growth rate is treated as a proximal metric for understanding the cellular metabolic status. However, changes in growth rate might not reflect metabolic variations in individuals responding to environmental fluctuations. Here we use single-cell microfluidics-microscopy combined with transcriptomics, proteomics and mathematical modelling to quantify the accumulation of glucose within Escherichia coli cells. In contrast to the current consensus, we reveal that environmental conditions which are comparatively unfavourable for growth, where both nutrients and salinity are depleted, increase glucose accumulation rates in individual bacteria and population subsets. We find that these changes in metabolic function are underpinned by variations at the translational and posttranslational level but not at the transcriptional level and are not dictated by changes in cell size. The metabolic response-characteristics identified greatly advance our fundamental understanding of the interactions between bacteria and their environment and have important ramifications when investigating cellular processes where salinity plays an important role.","lang":"eng"}],"language":[{"iso":"eng"}],"_id":"11339","article_type":"original","day":"20","publisher":"Springer Nature","file":[{"file_id":"11342","creator":"dernst","content_type":"application/pdf","file_size":2827723,"success":1,"checksum":"7c6f76ab17393d650825cc240edc84b3","file_name":"2022_CommBiology_Glover.pdf","access_level":"open_access","date_updated":"2022-05-02T06:26:26Z","date_created":"2022-05-02T06:26:26Z","relation":"main_file"}],"external_id":{"pmid":["35444215"],"isi":["000784143400001"]},"file_date_updated":"2022-05-02T06:26:26Z","doi":"10.1038/s42003-022-03336-6","oa_version":"Published Version","ddc":["570"],"scopus_import":"1","title":"Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells","quality_controlled":"1","article_processing_charge":"No","acknowledgement":"G.G. was supported by an EPSRC DTP PhD studentship (EP/M506527/1). M.V. and K.T.A. gratefully acknowledge financial support from the EPSRC (EP/N014391/1). U.L. was supported through a BBSRC grant (BB/V008021/1) and an MRC Proximity to Discovery EXCITEME2 grant (MCPC17189). This work was further supported by a Royal Society Research Grant (RG180007) awarded to S.P. and a QUEX Initiator grant awarded to S.P. and K.T.A.. D.S.M., T.A.R. and S.P.’s work in this area is also supported by a Marie Skłodowska-Curie project SINGEK (H2020-MSCA-ITN-2015-675752) and the Gordon and Betty Moore Foundation Marine Microbiology Initiative (GBMF5514). B.M.I. acknowledges support from a Wellcome Trust Institutional Strategic Support Award to the University of Exeter (204909/Z/16/Z). This project utilised equipment funded by the Wellcome Trust Institutional Strategic Support Fund (WT097835MF), Wellcome Trust Multi User Equipment Award (WT101650MA) and BBSRC LOLA award (BB/K003240/1).","publication":"Communications Biology","pmid":1,"publication_status":"published","department":[{"_id":"CaGu"}],"date_published":"2022-04-20T00:00:00Z","year":"2022","status":"public","month":"04","date_created":"2022-05-01T22:01:41Z","isi":1,"author":[{"first_name":"Georgina","last_name":"Glover","full_name":"Glover, Georgina"},{"first_name":"Margaritis","last_name":"Voliotis","full_name":"Voliotis, Margaritis"},{"first_name":"Urszula","last_name":"Łapińska","full_name":"Łapińska, Urszula"},{"first_name":"Brandon M.","last_name":"Invergo","full_name":"Invergo, Brandon M."},{"full_name":"Soanes, Darren","first_name":"Darren","last_name":"Soanes"},{"full_name":"O’Neill, Paul","last_name":"O’Neill","first_name":"Paul"},{"last_name":"Moore","first_name":"Karen","full_name":"Moore, Karen"},{"orcid":"0000-0001-9068-6090","full_name":"Nikolic, Nela","id":"42D9CABC-F248-11E8-B48F-1D18A9856A87","first_name":"Nela","last_name":"Nikolic"},{"full_name":"Petrov, Peter","last_name":"Petrov","first_name":"Peter"},{"full_name":"Milner, David S.","first_name":"David S.","last_name":"Milner"},{"last_name":"Roy","first_name":"Sumita","full_name":"Roy, Sumita"},{"last_name":"Heesom","first_name":"Kate","full_name":"Heesom, Kate"},{"first_name":"Thomas A.","last_name":"Richards","full_name":"Richards, Thomas A."},{"last_name":"Tsaneva-Atanasova","first_name":"Krasimira","full_name":"Tsaneva-Atanasova, Krasimira"},{"last_name":"Pagliara","first_name":"Stefano","full_name":"Pagliara, Stefano"}],"intvolume":" 5","publication_identifier":{"eissn":["2399-3642"]}},{"acknowledgement":"We thank Martin Trulsson for useful discussions and for providing us with simulation data. This work has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 674979-NANOTRANS. The support received from VEGA Grant No. 2/0092/21 is acknowledged.","pmid":1,"publication":"Journal of Physical Chemistry B","article_processing_charge":"No","scopus_import":"1","quality_controlled":"1","title":"Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring","oa_version":"Preprint","external_id":{"arxiv":["2203.10524"],"isi":["000796953700022"],"pmid":["35420420"]},"doi":"10.1021/acs.jpcb.2c00028","arxiv":1,"date_created":"2022-05-01T22:01:42Z","isi":1,"intvolume":" 126","publication_identifier":{"eissn":["1520-5207"],"issn":["1520-6106"]},"author":[{"last_name":"Palaia","first_name":"Ivan","full_name":"Palaia, Ivan","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","orcid":" 0000-0002-8843-9485 "},{"first_name":"Abhay","last_name":"Goyal","full_name":"Goyal, Abhay"},{"first_name":"Emanuela","last_name":"Del Gado","full_name":"Del Gado, Emanuela"},{"full_name":"Šamaj, Ladislav","last_name":"Šamaj","first_name":"Ladislav"},{"first_name":"Emmanuel","last_name":"Trizac","full_name":"Trizac, Emmanuel"}],"year":"2022","month":"04","status":"public","date_published":"2022-04-14T00:00:00Z","main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2203.10524"}],"publication_status":"published","department":[{"_id":"AnSa"}],"date_updated":"2025-06-11T13:34:36Z","language":[{"iso":"eng"}],"abstract":[{"text":"Like-charge attraction, driven by ionic correlations, challenges our understanding of electrostatics both in soft and hard matter. For two charged planar surfaces confining counterions and water, we prove that, even at relatively low correlation strength, the relevant physics is the ground-state one, oblivious of fluctuations. Based on this, we derive a simple and accurate interaction pressure that fulfills known exact requirements and can be used as an effective potential. We test this equation against implicit-solvent Monte Carlo simulations and against explicit-solvent simulations of cement and several types of clays. We argue that water destructuring under nanometric confinement drastically reduces dielectric screening, enhancing ionic correlations. Our equation of state at reduced permittivity therefore explains the exotic attractive regime reported for these materials, even in the absence of multivalent counterions.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"volume":126,"type":"journal_article","issue":"16","citation":{"ista":"Palaia I, Goyal A, Del Gado E, Šamaj L, Trizac E. 2022. Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring. Journal of Physical Chemistry B. 126(16), 3143–3149.","apa":"Palaia, I., Goyal, A., Del Gado, E., Šamaj, L., & Trizac, E. (2022). Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring. Journal of Physical Chemistry B. American Chemical Society. https://doi.org/10.1021/acs.jpcb.2c00028","chicago":"Palaia, Ivan, Abhay Goyal, Emanuela Del Gado, Ladislav Šamaj, and Emmanuel Trizac. “Like-Charge Attraction at the Nanoscale: Ground-State Correlations and Water Destructuring.” Journal of Physical Chemistry B. American Chemical Society, 2022. https://doi.org/10.1021/acs.jpcb.2c00028.","ieee":"I. Palaia, A. Goyal, E. Del Gado, L. Šamaj, and E. Trizac, “Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring,” Journal of Physical Chemistry B, vol. 126, no. 16. American Chemical Society, pp. 3143–3149, 2022.","short":"I. Palaia, A. Goyal, E. Del Gado, L. Šamaj, E. Trizac, Journal of Physical Chemistry B 126 (2022) 3143–3149.","ama":"Palaia I, Goyal A, Del Gado E, Šamaj L, Trizac E. Like-charge attraction at the nanoscale: Ground-state correlations and water destructuring. Journal of Physical Chemistry B. 2022;126(16):3143-3149. doi:10.1021/acs.jpcb.2c00028","mla":"Palaia, Ivan, et al. “Like-Charge Attraction at the Nanoscale: Ground-State Correlations and Water Destructuring.” Journal of Physical Chemistry B, vol. 126, no. 16, American Chemical Society, 2022, pp. 3143–49, doi:10.1021/acs.jpcb.2c00028."},"publisher":"American Chemical Society","day":"14","_id":"11340","article_type":"original","page":"3143-3149"},{"year":"2022","status":"public","month":"05","date_created":"2022-05-01T22:01:42Z","isi":1,"author":[{"last_name":"Lukacisin","first_name":"Martin","full_name":"Lukacisin, Martin","id":"298FFE8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6549-4177"},{"last_name":"Espinosa-Cantú","first_name":"Adriana","full_name":"Espinosa-Cantú, Adriana"},{"id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","full_name":"Bollenbach, Mark Tobias","orcid":"0000-0003-4398-476X","last_name":"Bollenbach","first_name":"Mark Tobias"}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"intvolume":" 605","publication_status":"published","ec_funded":1,"date_published":"2022-05-05T00:00:00Z","article_processing_charge":"No","acknowledgement":"We thank the IST Austria Life Science Facility, the Miba Machine Shop and M. Lukačišinová for support with the liquid handling robot; the Bioimaging Facility at IST Austria, J. Power and B. Meier at the University of Cologne, and C. Göttlinger at the FACS Analysis Facility at the Institute for Genetics, University of Cologne, for support with flow cytometry experiments; L. Horst for the development of the automated experimental methods in Cologne; J. Parenteau, S. Abou Elela, G. Stormo, M. Springer and M. Schuldiner for providing us with yeast strains; B. Fernando, T. Fink, G. Ansmann and G. Chevreau for technical support; H. Köver, G. Tkačik, N. Barton, A. Angermayr and B. Kavčič for support during laboratory relocation; D. Siekhaus, M. Springer and all the members of the Bollenbach group for support and discussions; and K. Mitosch, M. Lukačišinová, G. Liti and A. de Luna for critical reading of our manuscript. This work was supported in part by an Austrian Science Fund (FWF) standalone grant P 27201-B22 (to T.B.), HFSP program Grant RGP0042/2013 (to T.B.), EU Marie Curie Career Integration Grant No. 303507, and German Research Foundation (DFG) Collaborative Research Centre (SFB) 1310 (to T.B.). A.E.-C. was supported by a Georg Forster fellowship from the Alexander von Humboldt Foundation.","publication":"Nature","pmid":1,"file":[{"content_type":"application/pdf","file_id":"11727","creator":"dernst","checksum":"d68cd1596bb9fd819b750fe47c8a138a","success":1,"file_size":25360311,"access_level":"open_access","file_name":"2022_Nature_Lukacisin.pdf","date_created":"2022-08-05T06:08:24Z","date_updated":"2022-08-05T06:08:24Z","relation":"main_file"}],"doi":"10.1038/s41586-022-04633-0","file_date_updated":"2022-08-05T06:08:24Z","oa_version":"Published Version","external_id":{"pmid":["35444278"],"isi":["000784934100003"]},"ddc":["570"],"scopus_import":"1","title":"Intron-mediated induction of phenotypic heterogeneity","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"Bio"}],"quality_controlled":"1","_id":"11341","article_type":"original","day":"05","publisher":"Springer Nature","page":"113-118","oa":1,"project":[{"name":"Optimality principles in responses to antibiotics","call_identifier":"FP7","grant_number":"303507","_id":"25E83C2C-B435-11E9-9278-68D0E5697425"},{"name":"Revealing the mechanisms underlying drug interactions","_id":"25E9AF9E-B435-11E9-9278-68D0E5697425","grant_number":"P27201-B22","call_identifier":"FWF"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","type":"journal_article","volume":605,"date_updated":"2025-04-14T09:40:45Z","abstract":[{"text":"Intragenic regions that are removed during maturation of the RNA transcript—introns—are universally present in the nuclear genomes of eukaryotes1. The budding yeast, an otherwise intron-poor species, preserves two sets of ribosomal protein genes that differ primarily in their introns2,3. Although studies have shed light on the role of ribosomal protein introns under stress and starvation4,5,6, understanding the contribution of introns to ribosome regulation remains challenging. Here, by combining isogrowth profiling7 with single-cell protein measurements8, we show that introns can mediate inducible phenotypic heterogeneity that confers a clear fitness advantage. Osmotic stress leads to bimodal expression of the small ribosomal subunit protein Rps22B, which is mediated by an intron in the 5′ untranslated region of its transcript. The two resulting yeast subpopulations differ in their ability to cope with starvation. Low levels of Rps22B protein result in prolonged survival under sustained starvation, whereas high levels of Rps22B enable cells to grow faster after transient starvation. Furthermore, yeasts growing at high concentrations of sugar, similar to those in ripe grapes, exhibit bimodal expression of Rps22B when approaching the stationary phase. Differential intron-mediated regulation of ribosomal protein genes thus provides a way to diversify the population when starvation threatens in natural environments. Our findings reveal a role for introns in inducing phenotypic heterogeneity in changing environments, and suggest that duplicated ribosomal protein genes in yeast contribute to resolving the evolutionary conflict between precise expression control and environmental responsiveness9.","lang":"eng"}],"language":[{"iso":"eng"}],"citation":{"ista":"Lukacisin M, Espinosa-Cantú A, Bollenbach MT. 2022. Intron-mediated induction of phenotypic heterogeneity. Nature. 605, 113–118.","ieee":"M. Lukacisin, A. Espinosa-Cantú, and M. T. Bollenbach, “Intron-mediated induction of phenotypic heterogeneity,” Nature, vol. 605. Springer Nature, pp. 113–118, 2022.","chicago":"Lukacisin, Martin, Adriana Espinosa-Cantú, and Mark Tobias Bollenbach. “Intron-Mediated Induction of Phenotypic Heterogeneity.” Nature. Springer Nature, 2022. https://doi.org/10.1038/s41586-022-04633-0.","apa":"Lukacisin, M., Espinosa-Cantú, A., & Bollenbach, M. T. (2022). Intron-mediated induction of phenotypic heterogeneity. Nature. Springer Nature. https://doi.org/10.1038/s41586-022-04633-0","ama":"Lukacisin M, Espinosa-Cantú A, Bollenbach MT. Intron-mediated induction of phenotypic heterogeneity. Nature. 2022;605:113-118. doi:10.1038/s41586-022-04633-0","short":"M. Lukacisin, A. Espinosa-Cantú, M.T. Bollenbach, Nature 605 (2022) 113–118.","mla":"Lukacisin, Martin, et al. “Intron-Mediated Induction of Phenotypic Heterogeneity.” Nature, vol. 605, Springer Nature, 2022, pp. 113–18, doi:10.1038/s41586-022-04633-0."},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1"},{"publisher":"Springer Nature","day":"01","_id":"11343","article_type":"original","page":"3209-3218","abstract":[{"lang":"eng","text":"Multistable systems are characterized by exhibiting domain coexistence, where each domain accounts for the different equilibrium states. In case these systems are described by vectorial fields, domains can be connected through topological defects. Vortices are one of the most frequent and studied topological defect points. Optical vortices are equally relevant for their fundamental features as beams with topological features and their applications in image processing, telecommunications, optical tweezers, and quantum information. A natural source of optical vortices is the interaction of light beams with matter vortices in liquid crystal cells. The rhythms that govern the emergence of matter vortices due to fluctuations are not established. Here, we investigate the nucleation mechanisms of the matter vortices in liquid crystal cells and establish statistical laws that govern them. Based on a stochastic amplitude equation, the law for the number of nucleated vortices as a function of anisotropy, voltage, and noise level intensity is set. Experimental observations in a nematic liquid crystal cell with homeotropic anchoring and a negative anisotropic dielectric constant under the influence of a transversal electric field show a qualitative agreement with the theoretical findings."}],"language":[{"iso":"eng"}],"date_updated":"2024-10-09T21:02:21Z","keyword":["Electrical and Electronic Engineering","Applied Mathematics","Mechanical Engineering","Ocean Engineering","Aerospace Engineering","Control and Systems Engineering"],"type":"journal_article","volume":108,"oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","citation":{"short":"E. Aguilera, M.G. Clerc, V. Zambra, Nonlinear Dynamics 108 (2022) 3209–3218.","ama":"Aguilera E, Clerc MG, Zambra V. Vortices nucleation by inherent fluctuations in nematic liquid crystal cells. Nonlinear Dynamics. 2022;108:3209-3218. doi:10.1007/s11071-022-07396-5","mla":"Aguilera, Esteban, et al. “Vortices Nucleation by Inherent Fluctuations in Nematic Liquid Crystal Cells.” Nonlinear Dynamics, vol. 108, Springer Nature, 2022, pp. 3209–18, doi:10.1007/s11071-022-07396-5.","ista":"Aguilera E, Clerc MG, Zambra V. 2022. Vortices nucleation by inherent fluctuations in nematic liquid crystal cells. Nonlinear Dynamics. 108, 3209–3218.","apa":"Aguilera, E., Clerc, M. G., & Zambra, V. (2022). Vortices nucleation by inherent fluctuations in nematic liquid crystal cells. Nonlinear Dynamics. Springer Nature. https://doi.org/10.1007/s11071-022-07396-5","chicago":"Aguilera, Esteban, Marcel G. Clerc, and Valeska Zambra. “Vortices Nucleation by Inherent Fluctuations in Nematic Liquid Crystal Cells.” Nonlinear Dynamics. Springer Nature, 2022. https://doi.org/10.1007/s11071-022-07396-5.","ieee":"E. Aguilera, M. G. Clerc, and V. Zambra, “Vortices nucleation by inherent fluctuations in nematic liquid crystal cells,” Nonlinear Dynamics, vol. 108. Springer Nature, pp. 3209–3218, 2022."},"author":[{"last_name":"Aguilera","first_name":"Esteban","full_name":"Aguilera, Esteban"},{"first_name":"Marcel G.","last_name":"Clerc","full_name":"Clerc, Marcel G."},{"first_name":"Valeska","last_name":"Zambra","id":"467ed36b-dc96-11ea-b7c8-b043a380b282","full_name":"Zambra, Valeska"}],"intvolume":" 108","publication_identifier":{"eissn":["1573-269X"],"issn":["0924-090X"]},"isi":1,"date_created":"2022-05-02T07:01:59Z","status":"public","month":"06","year":"2022","date_published":"2022-06-01T00:00:00Z","corr_author":"1","department":[{"_id":"KiMo"}],"publication_status":"published","publication":"Nonlinear Dynamics","acknowledgement":"The authors thank Enrique Calisto,Michal Kowalczyk, and Michel Ferre for fructified discussions. This work was funded by ANID—Millennium Science Initiative Program—ICN17_012. MGC is thankful for financial support from the Fondecyt 1210353 project.\r\nOpen access funding provided by Institute of Science and Technology (IST Austria).","article_processing_charge":"Yes (via OA deal)","title":"Vortices nucleation by inherent fluctuations in nematic liquid crystal cells","quality_controlled":"1","scopus_import":"1","doi":"10.1007/s11071-022-07396-5","external_id":{"isi":["000784871800001"]},"oa_version":"Published Version","file_date_updated":"2022-08-05T06:13:19Z","ddc":["530"],"file":[{"date_updated":"2022-08-05T06:13:19Z","date_created":"2022-08-05T06:13:19Z","access_level":"open_access","file_name":"2022_NonlinearDyn_Aguilera.pdf","success":1,"checksum":"7d80cdece4e1b1c2106e6772a9622f60","file_size":1416049,"file_id":"11728","content_type":"application/pdf","creator":"dernst","relation":"main_file"}]},{"date_updated":"2025-04-15T08:25:40Z","abstract":[{"text":"One hallmark of plant cells is their cell wall. They protect cells against the environment and high turgor and mediate morphogenesis through the dynamics of their mechanical and chemical properties. The walls are a complex polysaccharidic structure. Although their biochemical composition is well known, how the different components organize in the volume of the cell wall and interact with each other is not well understood and yet is key to the wall’s mechanical properties. To investigate the ultrastructure of the plant cell wall, we imaged the walls of onion (Allium cepa) bulbs in a near-native state via cryo-focused ion beam milling (cryo-FIB milling) and cryo-electron tomography (cryo-ET). This allowed the high-resolution visualization of cellulose fibers in situ. We reveal the coexistence of dense fiber fields bathed in a reticulated matrix we termed “meshing,” which is more abundant at the inner surface of the cell wall. The fibers adopted a regular bimodal angular distribution at all depths in the cell wall and bundled according to their orientation, creating layers within the cell wall. Concomitantly, employing homogalacturonan (HG)-specific enzymatic digestion, we observed changes in the meshing, suggesting that it is—at least in part—composed of HG pectins. We propose the following model for the construction of the abaxial epidermal primary cell wall: the cell deposits successive layers of cellulose fibers at −45° and +45° relative to the cell’s long axis and secretes the surrounding HG-rich meshing proximal to the plasma membrane, which then migrates to more distal regions of the cell wall.","lang":"eng"}],"language":[{"iso":"eng"}],"oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","project":[{"name":"Structure and isoform diversity of the Arp2/3 complex","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","grant_number":"P33367"}],"keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"type":"journal_article","volume":32,"issue":"11","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"mla":"Nicolas, William J., et al. “Cryo-Electron Tomography of the Onion Cell Wall Shows Bimodally Oriented Cellulose Fibers and Reticulated Homogalacturonan Networks.” Current Biology, vol. 32, no. 11, Elsevier, 2022, pp. P2375-2389, doi:10.1016/j.cub.2022.04.024.","short":"W.J. Nicolas, F. Fäßler, P. Dutka, F.K. Schur, G. Jensen, E. Meyerowitz, Current Biology 32 (2022) P2375-2389.","ama":"Nicolas WJ, Fäßler F, Dutka P, Schur FK, Jensen G, Meyerowitz E. Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks. Current Biology. 2022;32(11):P2375-2389. doi:10.1016/j.cub.2022.04.024","apa":"Nicolas, W. J., Fäßler, F., Dutka, P., Schur, F. K., Jensen, G., & Meyerowitz, E. (2022). Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2022.04.024","ieee":"W. J. Nicolas, F. Fäßler, P. Dutka, F. K. Schur, G. Jensen, and E. Meyerowitz, “Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks,” Current Biology, vol. 32, no. 11. Elsevier, pp. P2375-2389, 2022.","chicago":"Nicolas, William J., Florian Fäßler, Przemysław Dutka, Florian KM Schur, Grant Jensen, and Elliot Meyerowitz. “Cryo-Electron Tomography of the Onion Cell Wall Shows Bimodally Oriented Cellulose Fibers and Reticulated Homogalacturonan Networks.” Current Biology. Elsevier, 2022. https://doi.org/10.1016/j.cub.2022.04.024.","ista":"Nicolas WJ, Fäßler F, Dutka P, Schur FK, Jensen G, Meyerowitz E. 2022. Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks. Current Biology. 32(11), P2375-2389."},"day":"06","publisher":"Elsevier","_id":"11351","article_type":"original","page":"P2375-2389","acknowledgement":"This work was supported by the Howard Hughes Medical Institute (HHMI) and grant R35 GM122588 to G.J. and the Austrian Science Fund (FWF) P33367 to F.K.M.S. We thank Noé Cochetel for his guidance and great help in data analysis, discovery, and representation with the R software. We thank Hans-Ulrich Endress for graciously providing us with the purified citrus pectin and Jozef Mravec for generating and providing the COS488 probe. Cryo-EM work was done in the Beckman Institute Resource Center for Transmission Electron Microscopy at Caltech. This article is subject to HHMI’s Open Access to Publications policy. HHMI lab heads have previously granted a nonexclusive CC BY 4.0 license to the public and a sublicensable license to HHMI in their research articles. Pursuant to those licenses, the author accepted manuscript of this article can be made freely available under a CC BY 4.0 license immediately upon publication.","pmid":1,"publication":"Current Biology","article_processing_charge":"No","scopus_import":"1","title":"Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks","quality_controlled":"1","file":[{"relation":"main_file","date_created":"2022-08-05T06:29:18Z","date_updated":"2022-08-05T06:29:18Z","access_level":"open_access","file_name":"2022_CurrentBiology_Nicolas.pdf","success":1,"checksum":"af3f24d97c016d844df237abef987639","file_size":12827717,"file_id":"11730","content_type":"application/pdf","creator":"dernst"}],"doi":"10.1016/j.cub.2022.04.024","oa_version":"Published Version","external_id":{"pmid":["35508170"],"isi":["000822399200019"]},"file_date_updated":"2022-08-05T06:29:18Z","ddc":["570"],"date_created":"2022-05-04T06:22:06Z","isi":1,"author":[{"full_name":"Nicolas, William J.","last_name":"Nicolas","first_name":"William J."},{"orcid":"0000-0001-7149-769X","id":"404F5528-F248-11E8-B48F-1D18A9856A87","full_name":"Fäßler, Florian","first_name":"Florian","last_name":"Fäßler"},{"full_name":"Dutka, Przemysław","last_name":"Dutka","first_name":"Przemysław"},{"last_name":"Schur","first_name":"Florian KM","full_name":"Schur, Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4790-8078"},{"last_name":"Jensen","first_name":"Grant","full_name":"Jensen, Grant"},{"full_name":"Meyerowitz, Elliot","last_name":"Meyerowitz","first_name":"Elliot"}],"publication_identifier":{"issn":["0960-9822"]},"intvolume":" 32","year":"2022","status":"public","month":"06","date_published":"2022-06-06T00:00:00Z","publication_status":"published","department":[{"_id":"FlSc"}]},{"page":"591-648","publisher":"Institute of Mathematical Statistics","day":"01","_id":"11354","article_type":"original","issue":"2","citation":{"short":"L. Dello Schiavo, Annals of Probability 50 (2022) 591–648.","ama":"Dello Schiavo L. The Dirichlet–Ferguson diffusion on the space of probability measures over a closed Riemannian manifold. Annals of Probability. 2022;50(2):591-648. doi:10.1214/21-AOP1541","mla":"Dello Schiavo, Lorenzo. “The Dirichlet–Ferguson Diffusion on the Space of Probability Measures over a Closed Riemannian Manifold.” Annals of Probability, vol. 50, no. 2, Institute of Mathematical Statistics, 2022, pp. 591–648, doi:10.1214/21-AOP1541.","ista":"Dello Schiavo L. 2022. The Dirichlet–Ferguson diffusion on the space of probability measures over a closed Riemannian manifold. Annals of Probability. 50(2), 591–648.","apa":"Dello Schiavo, L. (2022). The Dirichlet–Ferguson diffusion on the space of probability measures over a closed Riemannian manifold. Annals of Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/21-AOP1541","chicago":"Dello Schiavo, Lorenzo. “The Dirichlet–Ferguson Diffusion on the Space of Probability Measures over a Closed Riemannian Manifold.” Annals of Probability. Institute of Mathematical Statistics, 2022. https://doi.org/10.1214/21-AOP1541.","ieee":"L. Dello Schiavo, “The Dirichlet–Ferguson diffusion on the space of probability measures over a closed Riemannian manifold,” Annals of Probability, vol. 50, no. 2. Institute of Mathematical Statistics, pp. 591–648, 2022."},"date_updated":"2025-04-14T07:27:47Z","abstract":[{"lang":"eng","text":"We construct a recurrent diffusion process with values in the space of probability measures over an arbitrary closed Riemannian manifold of dimension d≥2. The process is associated with the Dirichlet form defined by integration of the Wasserstein gradient w.r.t. the Dirichlet–Ferguson measure, and is the counterpart on multidimensional base spaces to the modified massive Arratia flow over the unit interval described in V. Konarovskyi and M.-K. von Renesse (Comm. Pure Appl. Math. 72 (2019) 764–800). Together with two different constructions of the process, we discuss its ergodicity, invariant sets, finite-dimensional approximations, and Varadhan short-time asymptotics."}],"language":[{"iso":"eng"}],"oa":1,"project":[{"grant_number":"716117","_id":"256E75B8-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Optimal Transport and Stochastic Dynamics"},{"name":"Taming Complexity in Partial Differential Systems","grant_number":"F6504","_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":50,"type":"journal_article","corr_author":"1","ec_funded":1,"date_published":"2022-03-01T00:00:00Z","main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.1811.11598"}],"publication_status":"published","department":[{"_id":"JaMa"}],"isi":1,"date_created":"2022-05-08T22:01:44Z","arxiv":1,"author":[{"id":"ECEBF480-9E4F-11EA-B557-B0823DDC885E","full_name":"Dello Schiavo, Lorenzo","orcid":"0000-0002-9881-6870","last_name":"Dello Schiavo","first_name":"Lorenzo"}],"publication_identifier":{"issn":["0091-1798"],"eissn":["2168-894X"]},"intvolume":" 50","year":"2022","status":"public","month":"03","scopus_import":"1","title":"The Dirichlet–Ferguson diffusion on the space of probability measures over a closed Riemannian manifold","quality_controlled":"1","oa_version":"Preprint","doi":"10.1214/21-AOP1541","external_id":{"isi":["000773518500005"],"arxiv":["1811.11598"]},"acknowledgement":"Research supported by the Sonderforschungsbereich 1060 and the Hausdorff Center for Mathematics. The author gratefully acknowledges funding of his current position at IST Austria by the Austrian Science Fund (FWF) grant F65 and by the European Research Council (ERC, Grant agreement No. 716117, awarded to Prof. Dr. Jan Maas).","publication":"Annals of Probability","article_processing_charge":"No"},{"isi":1,"date_created":"2022-05-08T22:01:44Z","publication_identifier":{"isbn":["9783030994280"],"issn":["0302-9743"],"eissn":["1611-3349"]},"intvolume":" 13241","author":[{"full_name":"Bartocci, Ezio","last_name":"Bartocci","first_name":"Ezio"},{"orcid":"0000-0001-5199-3143","full_name":"Ferrere, Thomas","id":"40960E6E-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas","last_name":"Ferrere"},{"first_name":"Thomas A","last_name":"Henzinger","orcid":"0000-0002-2985-7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A"},{"id":"41BCEE5C-F248-11E8-B48F-1D18A9856A87","full_name":"Nickovic, Dejan","first_name":"Dejan","last_name":"Nickovic"},{"full_name":"Da Costa, Ana Oliveira","last_name":"Da Costa","first_name":"Ana Oliveira"}],"year":"2022","month":"03","status":"public","date_published":"2022-03-29T00:00:00Z","ec_funded":1,"publication_status":"published","department":[{"_id":"ToHe"}],"acknowledgement":"This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 956123 and was funded in part by the FWF project W1255-N23 and by the ERC-2020-AdG 101020093.","publication":"Fundamental Approaches to Software Engineering","article_processing_charge":"No","alternative_title":["LNCS"],"scopus_import":"1","quality_controlled":"1","title":"Information-flow interfaces","file":[{"relation":"main_file","content_type":"application/pdf","file_id":"11357","creator":"dernst","file_size":479146,"success":1,"checksum":"7f6f860b20b8de2a249e9c1b4eee15cf","file_name":"2022_LNCS_Bartocci.pdf","access_level":"open_access","date_created":"2022-05-09T06:52:44Z","date_updated":"2022-05-09T06:52:44Z"}],"ddc":["000"],"oa_version":"Published Version","external_id":{"isi":["000782393600001"]},"doi":"10.1007/978-3-030-99429-7_1","file_date_updated":"2022-05-09T06:52:44Z","publisher":"Springer Nature","day":"29","related_material":{"record":[{"status":"public","id":"17094","relation":"extended_version"}]},"_id":"11355","page":"3-22","date_updated":"2025-12-30T06:50:51Z","language":[{"iso":"eng"}],"abstract":[{"text":"Contract-based design is a promising methodology for taming the complexity of developing sophisticated systems. A formal contract distinguishes between assumptions, which are constraints that the designer of a component puts on the environments in which the component can be used safely, and guarantees, which are promises that the designer asks from the team that implements the component. A theory of formal contracts can be formalized as an interface theory, which supports the composition and refinement of both assumptions and guarantees.\r\nAlthough there is a rich landscape of contract-based design methods that address functional and extra-functional properties, we present the first interface theory that is designed for ensuring system-wide security properties. Our framework provides a refinement relation and a composition operation that support both incremental design and independent implementability. We develop our theory for both stateless and stateful interfaces. We illustrate the applicability of our framework with an example inspired from the automotive domain.","lang":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","project":[{"call_identifier":"H2020","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","grant_number":"101020093","name":"Vigilant Algorithmic Monitoring of Software"}],"oa":1,"type":"conference","volume":13241,"conference":{"location":"Munich, Germany","end_date":"2022-04-07","name":"FASE: Fundamental Approaches to Software Engineering","start_date":"2022-04-02"},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","citation":{"mla":"Bartocci, Ezio, et al. “Information-Flow Interfaces.” Fundamental Approaches to Software Engineering, vol. 13241, Springer Nature, 2022, pp. 3–22, doi:10.1007/978-3-030-99429-7_1.","ama":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. Information-flow interfaces. In: Fundamental Approaches to Software Engineering. Vol 13241. Springer Nature; 2022:3-22. doi:10.1007/978-3-030-99429-7_1","short":"E. Bartocci, T. Ferrere, T.A. Henzinger, D. Nickovic, A.O. Da Costa, in:, Fundamental Approaches to Software Engineering, Springer Nature, 2022, pp. 3–22.","chicago":"Bartocci, Ezio, Thomas Ferrere, Thomas A Henzinger, Dejan Nickovic, and Ana Oliveira Da Costa. “Information-Flow Interfaces.” In Fundamental Approaches to Software Engineering, 13241:3–22. Springer Nature, 2022. https://doi.org/10.1007/978-3-030-99429-7_1.","ieee":"E. Bartocci, T. Ferrere, T. A. Henzinger, D. Nickovic, and A. O. Da Costa, “Information-flow interfaces,” in Fundamental Approaches to Software Engineering, Munich, Germany, 2022, vol. 13241, pp. 3–22.","apa":"Bartocci, E., Ferrere, T., Henzinger, T. A., Nickovic, D., & Da Costa, A. O. (2022). Information-flow interfaces. In Fundamental Approaches to Software Engineering (Vol. 13241, pp. 3–22). Munich, Germany: Springer Nature. https://doi.org/10.1007/978-3-030-99429-7_1","ista":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. 2022. Information-flow interfaces. Fundamental Approaches to Software Engineering. FASE: Fundamental Approaches to Software Engineering, LNCS, vol. 13241, 3–22."}},{"project":[{"name":"Bottom-up Engineering for Thermoelectric Applications","_id":"9B8804FC-BA93-11EA-9121-9846C619BF3A","grant_number":"M02889"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"type":"journal_article","volume":67,"date_updated":"2025-06-11T13:50:42Z","language":[{"iso":"eng"}],"citation":{"ista":"Chang C, Qin B, Su L, Zhao LD. 2022. Distinct electron and hole transports in SnSe crystals. Science Bulletin. 67(11), 1105–1107.","apa":"Chang, C., Qin, B., Su, L., & Zhao, L. D. (2022). Distinct electron and hole transports in SnSe crystals. Science Bulletin. Elsevier. https://doi.org/10.1016/j.scib.2022.04.007","ieee":"C. Chang, B. Qin, L. Su, and L. D. Zhao, “Distinct electron and hole transports in SnSe crystals,” Science Bulletin, vol. 67, no. 11. Elsevier, pp. 1105–1107, 2022.","chicago":"Chang, Cheng, Bingchao Qin, Lizhong Su, and Li Dong Zhao. “Distinct Electron and Hole Transports in SnSe Crystals.” Science Bulletin. Elsevier, 2022. https://doi.org/10.1016/j.scib.2022.04.007.","short":"C. Chang, B. Qin, L. Su, L.D. Zhao, Science Bulletin 67 (2022) 1105–1107.","ama":"Chang C, Qin B, Su L, Zhao LD. Distinct electron and hole transports in SnSe crystals. Science Bulletin. 2022;67(11):1105-1107. doi:10.1016/j.scib.2022.04.007","mla":"Chang, Cheng, et al. “Distinct Electron and Hole Transports in SnSe Crystals.” Science Bulletin, vol. 67, no. 11, Elsevier, 2022, pp. 1105–07, doi:10.1016/j.scib.2022.04.007."},"issue":"11","_id":"11356","article_type":"letter_note","publisher":"Elsevier","day":"15","page":"1105-1107","article_processing_charge":"No","acknowledgement":"This work was supported by the National Science Fund for Distinguished Young Scholars (51925101), National Key Research and Development Program of China (2018YFA0702100), 111 Project (B17002), and Lise Meitner Project (M2889-N).","publication":"Science Bulletin","pmid":1,"external_id":{"pmid":["36545972"],"isi":["000835291100006"]},"doi":"10.1016/j.scib.2022.04.007","oa_version":"Published Version","scopus_import":"1","quality_controlled":"1","title":"Distinct electron and hole transports in SnSe crystals","year":"2022","month":"06","status":"public","date_created":"2022-05-08T22:01:44Z","isi":1,"publication_identifier":{"issn":["2095-9273"],"eissn":["2095-9281"]},"intvolume":" 67","author":[{"last_name":"Chang","first_name":"Cheng","id":"9E331C2E-9F27-11E9-AE48-5033E6697425","full_name":"Chang, Cheng","orcid":"0000-0002-9515-4277"},{"full_name":"Qin, Bingchao","last_name":"Qin","first_name":"Bingchao"},{"last_name":"Su","first_name":"Lizhong","full_name":"Su, Lizhong"},{"full_name":"Zhao, Li Dong","last_name":"Zhao","first_name":"Li Dong"}],"publication_status":"published","department":[{"_id":"MaIb"}],"date_published":"2022-06-15T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.scib.2022.04.007"}]},{"acknowledgement":"We acknowledge funding from the Center for Nanoscience (CeNS) and by the Deutsche\r\nForschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy-EXC-2111-390814868 (MCQST). K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan (Grant Number PMXP0112101001) and JSPS KAKENHI (Grant Numbers 19H05790 and JP20H00354).","pmid":1,"publication":"Nano Letters","article_processing_charge":"No","scopus_import":"1","quality_controlled":"1","title":"Spontaneous gully-polarized quantum hall states in ABA trilayer graphene","external_id":{"arxiv":["2109.00556"],"isi":["000809056900019"],"pmid":["35405074"]},"oa_version":"Preprint","doi":"10.1021/acs.nanolett.2c00435","arxiv":1,"date_created":"2022-05-15T22:01:41Z","isi":1,"publication_identifier":{"eissn":["1530-6992"],"issn":["1530-6984"]},"intvolume":" 22","author":[{"first_name":"Felix","last_name":"Winterer","full_name":"Winterer, Felix"},{"first_name":"Anna M.","last_name":"Seiler","full_name":"Seiler, Anna M."},{"last_name":"Ghazaryan","first_name":"Areg","full_name":"Ghazaryan, Areg","id":"4AF46FD6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9666-3543"},{"full_name":"Geisenhof, Fabian R.","last_name":"Geisenhof","first_name":"Fabian R."},{"full_name":"Watanabe, Kenji","first_name":"Kenji","last_name":"Watanabe"},{"full_name":"Taniguchi, Takashi","last_name":"Taniguchi","first_name":"Takashi"},{"last_name":"Serbyn","first_name":"Maksym","full_name":"Serbyn, Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2399-5827"},{"full_name":"Weitz, R. Thomas","first_name":"R. Thomas","last_name":"Weitz"}],"year":"2022","month":"04","status":"public","main_file_link":[{"url":" https://doi.org/10.48550/arXiv.2109.00556","open_access":"1"}],"date_published":"2022-04-27T00:00:00Z","publication_status":"published","department":[{"_id":"MaSe"}],"date_updated":"2025-06-11T13:47:08Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Bernal-stacked multilayer graphene is a versatile platform to explore quantum transport phenomena and interaction physics due to its exceptional tunability via electrostatic gating. For instance, upon applying a perpendicular electric field, its band structure exhibits several off-center Dirac points (so-called Dirac gullies) in each valley. Here, the formation of Dirac gullies and the interaction-induced breakdown of gully coherence is explored via magnetotransport measurements in high-quality Bernal-stacked (ABA) trilayer graphene. At zero magnetic field, multiple Lifshitz transitions indicating the formation of Dirac gullies are identified. In the quantum Hall regime, the emergence of Dirac gullies is evident as an increase in Landau level degeneracy. When tuning both electric and magnetic fields, electron–electron interactions can be controllably enhanced until, beyond critical electric and magnetic fields, the gully degeneracy is eventually lifted. The arising correlated ground state is consistent with a previously predicted nematic phase that spontaneously breaks the rotational gully symmetry."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"type":"journal_article","volume":22,"issue":"8","citation":{"mla":"Winterer, Felix, et al. “Spontaneous Gully-Polarized Quantum Hall States in ABA Trilayer Graphene.” Nano Letters, vol. 22, no. 8, American Chemical Society, 2022, pp. 3317–22, doi:10.1021/acs.nanolett.2c00435.","short":"F. Winterer, A.M. Seiler, A. Ghazaryan, F.R. Geisenhof, K. Watanabe, T. Taniguchi, M. Serbyn, R.T. Weitz, Nano Letters 22 (2022) 3317–3322.","ama":"Winterer F, Seiler AM, Ghazaryan A, et al. Spontaneous gully-polarized quantum hall states in ABA trilayer graphene. Nano Letters. 2022;22(8):3317-3322. doi:10.1021/acs.nanolett.2c00435","apa":"Winterer, F., Seiler, A. M., Ghazaryan, A., Geisenhof, F. R., Watanabe, K., Taniguchi, T., … Weitz, R. T. (2022). Spontaneous gully-polarized quantum hall states in ABA trilayer graphene. Nano Letters. American Chemical Society. https://doi.org/10.1021/acs.nanolett.2c00435","chicago":"Winterer, Felix, Anna M. Seiler, Areg Ghazaryan, Fabian R. Geisenhof, Kenji Watanabe, Takashi Taniguchi, Maksym Serbyn, and R. Thomas Weitz. “Spontaneous Gully-Polarized Quantum Hall States in ABA Trilayer Graphene.” Nano Letters. American Chemical Society, 2022. https://doi.org/10.1021/acs.nanolett.2c00435.","ieee":"F. Winterer et al., “Spontaneous gully-polarized quantum hall states in ABA trilayer graphene,” Nano Letters, vol. 22, no. 8. American Chemical Society, pp. 3317–3322, 2022.","ista":"Winterer F, Seiler AM, Ghazaryan A, Geisenhof FR, Watanabe K, Taniguchi T, Serbyn M, Weitz RT. 2022. Spontaneous gully-polarized quantum hall states in ABA trilayer graphene. Nano Letters. 22(8), 3317–3322."},"day":"27","publisher":"American Chemical Society","article_type":"original","_id":"11379","page":"3317-3322"},{"date_created":"2022-05-22T17:04:48Z","isi":1,"author":[{"orcid":" 0000-0002-8843-9485 ","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","full_name":"Palaia, Ivan","first_name":"Ivan","last_name":"Palaia"},{"orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela","last_name":"Šarić"}],"intvolume":" 156","publication_identifier":{"eissn":["1089-7690"],"issn":["0021-9606"]},"year":"2022","status":"public","month":"05","corr_author":"1","ec_funded":1,"date_published":"2022-05-16T00:00:00Z","publication_status":"published","department":[{"_id":"AnSa"}],"acknowledgement":"The authors thank Longhui Zeng and Xiaolei Su (Yale University) for bringing the topic to their attention and for useful comments. This work has received funding from the European Research Council under the European Union’s Horizon\r\n2020 research and innovation program (ERC Grant No. 802960 and Marie Skłodowska-Curie Grant No. 101034413). The authors are grateful to the UK Materials and Molecular Modeling Hub for computational resources, which is partially funded by EPSRC (Grant Nos. EP/P020194/1 and EP/T022213/1). The authors acknowledge support from ISTA and from the Royal Society (Grant No. UF160266).","pmid":1,"publication":"The Journal of Chemical Physics","article_processing_charge":"No","scopus_import":"1","title":"Controlling cluster size in 2D phase-separating binary mixtures with specific interactions","quality_controlled":"1","file":[{"date_updated":"2022-05-23T07:45:33Z","date_created":"2022-05-23T07:45:33Z","access_level":"open_access","file_name":"2022_JourChemPhysics_Palaia.pdf","checksum":"7fada58059676a4bb0944b82247af740","success":1,"file_size":6387208,"creator":"dernst","file_id":"11405","content_type":"application/pdf","relation":"main_file"}],"external_id":{"isi":["000797236000004"],"pmid":["35597653"]},"doi":"10.1063/5.0087769","oa_version":"Published Version","file_date_updated":"2022-05-23T07:45:33Z","ddc":["540"],"publisher":"AIP Publishing","day":"16","article_type":"original","_id":"11400","date_updated":"2025-06-11T14:00:32Z","abstract":[{"lang":"eng","text":"By varying the concentration of molecules in the cytoplasm or on the membrane, cells can induce the formation of condensates and liquid droplets, similar to phase separation. Their thermodynamics, much studied, depends on the mutual interactions between microscopic constituents. Here, we focus on the kinetics and size control of 2D clusters, forming on membranes. Using molecular dynamics of patchy colloids, we model a system of two species of proteins, giving origin to specific heterotypic bonds. We find that concentrations, together with valence and bond strength, control both the size and the growth time rate of the clusters. In particular, if one species is in large excess, it gradually saturates the binding sites of the other species; the system then becomes kinetically arrested and cluster coarsening slows down or stops, thus yielding effective size selection. This phenomenology is observed both in solid and fluid clusters, which feature additional generic homotypic interactions and are reminiscent of the ones observed on biological membranes."}],"language":[{"iso":"eng"}],"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines","call_identifier":"H2020","_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","grant_number":"802960"},{"name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020"}],"keyword":["Physical and Theoretical Chemistry","General Physics and Astronomy"],"type":"journal_article","volume":156,"issue":"19","article_number":"194902","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","citation":{"mla":"Palaia, Ivan, and Anđela Šarić. “Controlling Cluster Size in 2D Phase-Separating Binary Mixtures with Specific Interactions.” The Journal of Chemical Physics, vol. 156, no. 19, 194902, AIP Publishing, 2022, doi:10.1063/5.0087769.","ama":"Palaia I, Šarić A. Controlling cluster size in 2D phase-separating binary mixtures with specific interactions. The Journal of Chemical Physics. 2022;156(19). doi:10.1063/5.0087769","short":"I. Palaia, A. Šarić, The Journal of Chemical Physics 156 (2022).","ieee":"I. Palaia and A. Šarić, “Controlling cluster size in 2D phase-separating binary mixtures with specific interactions,” The Journal of Chemical Physics, vol. 156, no. 19. AIP Publishing, 2022.","chicago":"Palaia, Ivan, and Anđela Šarić. “Controlling Cluster Size in 2D Phase-Separating Binary Mixtures with Specific Interactions.” The Journal of Chemical Physics. AIP Publishing, 2022. https://doi.org/10.1063/5.0087769.","apa":"Palaia, I., & Šarić, A. (2022). Controlling cluster size in 2D phase-separating binary mixtures with specific interactions. The Journal of Chemical Physics. AIP Publishing. https://doi.org/10.1063/5.0087769","ista":"Palaia I, Šarić A. 2022. Controlling cluster size in 2D phase-separating binary mixtures with specific interactions. The Journal of Chemical Physics. 156(19), 194902."}},{"department":[{"_id":"MaIb"}],"publication_status":"published","date_published":"2022-05-13T00:00:00Z","month":"05","status":"public","year":"2022","intvolume":" 14","publication_identifier":{"issn":["1884-4049"],"eissn":["1884-4057"]},"author":[{"first_name":"Van Quang","last_name":"Nguyen","full_name":"Nguyen, Van Quang"},{"first_name":"Thi Ly","last_name":"Trinh","full_name":"Trinh, Thi Ly"},{"first_name":"Cheng","last_name":"Chang","orcid":"0000-0002-9515-4277","full_name":"Chang, Cheng","id":"9E331C2E-9F27-11E9-AE48-5033E6697425"},{"full_name":"Zhao, Li Dong","last_name":"Zhao","first_name":"Li Dong"},{"full_name":"Nguyen, Thi Huong","first_name":"Thi Huong","last_name":"Nguyen"},{"first_name":"Van Thiet","last_name":"Duong","full_name":"Duong, Van Thiet"},{"full_name":"Duong, Anh Tuan","first_name":"Anh Tuan","last_name":"Duong"},{"full_name":"Park, Jong Ho","first_name":"Jong Ho","last_name":"Park"},{"last_name":"Park","first_name":"Sudong","full_name":"Park, Sudong"},{"first_name":"Jungdae","last_name":"Kim","full_name":"Kim, Jungdae"},{"full_name":"Cho, Sunglae","first_name":"Sunglae","last_name":"Cho"}],"isi":1,"date_created":"2022-05-22T22:01:40Z","ddc":["540"],"doi":"10.1038/s41427-022-00393-5","oa_version":"Published Version","file_date_updated":"2022-05-23T06:47:57Z","external_id":{"isi":["000794880200001"]},"file":[{"relation":"main_file","date_created":"2022-05-23T06:47:57Z","date_updated":"2022-05-23T06:47:57Z","access_level":"open_access","file_name":"2022_NPGAsiaMaterials_Nguyen.pdf","success":1,"checksum":"0579997cc1d28bf66e29357e08e3e39d","file_size":6202545,"creator":"dernst","file_id":"11404","content_type":"application/pdf"}],"quality_controlled":"1","title":"Unidentified major p-type source in SnSe: Multivacancies","scopus_import":"1","article_processing_charge":"No","publication":"NPG Asia Materials","acknowledgement":"This work was supported by the National Research Foundation of Korea [NRF-2019R1F1A1058473, NRF-2019R1A6A1A11053838, and NRF-2020K1A4A7A02095438].","_id":"11401","article_type":"original","publisher":"Springer Nature","day":"13","citation":{"apa":"Nguyen, V. Q., Trinh, T. L., Chang, C., Zhao, L. D., Nguyen, T. H., Duong, V. T., … Cho, S. (2022). Unidentified major p-type source in SnSe: Multivacancies. NPG Asia Materials. Springer Nature. https://doi.org/10.1038/s41427-022-00393-5","ieee":"V. Q. Nguyen et al., “Unidentified major p-type source in SnSe: Multivacancies,” NPG Asia Materials, vol. 14. Springer Nature, 2022.","chicago":"Nguyen, Van Quang, Thi Ly Trinh, Cheng Chang, Li Dong Zhao, Thi Huong Nguyen, Van Thiet Duong, Anh Tuan Duong, et al. “Unidentified Major P-Type Source in SnSe: Multivacancies.” NPG Asia Materials. Springer Nature, 2022. https://doi.org/10.1038/s41427-022-00393-5.","ista":"Nguyen VQ, Trinh TL, Chang C, Zhao LD, Nguyen TH, Duong VT, Duong AT, Park JH, Park S, Kim J, Cho S. 2022. Unidentified major p-type source in SnSe: Multivacancies. NPG Asia Materials. 14, 42.","mla":"Nguyen, Van Quang, et al. “Unidentified Major P-Type Source in SnSe: Multivacancies.” NPG Asia Materials, vol. 14, 42, Springer Nature, 2022, doi:10.1038/s41427-022-00393-5.","short":"V.Q. Nguyen, T.L. Trinh, C. Chang, L.D. Zhao, T.H. Nguyen, V.T. Duong, A.T. Duong, J.H. Park, S. Park, J. Kim, S. Cho, NPG Asia Materials 14 (2022).","ama":"Nguyen VQ, Trinh TL, Chang C, et al. Unidentified major p-type source in SnSe: Multivacancies. NPG Asia Materials. 2022;14. doi:10.1038/s41427-022-00393-5"},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","article_number":"42","volume":14,"type":"journal_article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Tin selenide (SnSe) is considered a robust candidate for thermoelectric applications due to its very high thermoelectric figure of merit, ZT, with values of 2.6 in p-type and 2.8 in n-type single crystals. Sn has been replaced with various lower group dopants to achieve successful p-type doping in SnSe with high ZT values. A known, facile, and powerful alternative way to introduce a hole carrier is to use a natural single Sn vacancy, VSn. Through transport and scanning tunneling microscopy studies, we discovered that VSn are dominant in high-quality (slow cooling rate) SnSe single crystals, while multiple vacancies, Vmulti, are dominant in low-quality (high cooling rate) single crystals. Surprisingly, both VSn and Vmulti help to increase the power factors of SnSe, whereas samples with dominant VSn have superior thermoelectric properties in SnSe single crystals. Additionally, the observation that Vmulti are good p-type sources observed in relatively low-quality single crystals is useful in thermoelectric applications because polycrystalline SnSe can be used due to its mechanical strength; this substance is usually fabricated at very high cooling speeds."}],"date_updated":"2023-08-03T07:13:58Z"},{"citation":{"mla":"Chatterjee, Krishnendu, and Laurent Doyen. “Graph Planning with Expected Finite Horizon.” Journal of Computer and System Sciences, vol. 129, Elsevier, 2022, pp. 1–21, doi:10.1016/j.jcss.2022.04.003.","ama":"Chatterjee K, Doyen L. Graph planning with expected finite horizon. Journal of Computer and System Sciences. 2022;129:1-21. doi:10.1016/j.jcss.2022.04.003","short":"K. Chatterjee, L. Doyen, Journal of Computer and System Sciences 129 (2022) 1–21.","ieee":"K. Chatterjee and L. Doyen, “Graph planning with expected finite horizon,” Journal of Computer and System Sciences, vol. 129. Elsevier, pp. 1–21, 2022.","chicago":"Chatterjee, Krishnendu, and Laurent Doyen. “Graph Planning with Expected Finite Horizon.” Journal of Computer and System Sciences. Elsevier, 2022. https://doi.org/10.1016/j.jcss.2022.04.003.","apa":"Chatterjee, K., & Doyen, L. (2022). Graph planning with expected finite horizon. Journal of Computer and System Sciences. Elsevier. https://doi.org/10.1016/j.jcss.2022.04.003","ista":"Chatterjee K, Doyen L. 2022. Graph planning with expected finite horizon. Journal of Computer and System Sciences. 129, 1–21."},"date_updated":"2025-07-10T11:54:34Z","language":[{"iso":"eng"}],"abstract":[{"text":"Fixed-horizon planning considers a weighted graph and asks to construct a path that maximizes the sum of weights for a given time horizon T. However, in many scenarios, the time horizon is not fixed, but the stopping time is chosen according to some distribution such that the expected stopping time is T. If the stopping-time distribution is not known, then to ensure robustness, the distribution is chosen by an adversary as the worst-case scenario. A stationary plan for every vertex always chooses the same outgoing edge. For fixed horizon or fixed stopping-time distribution, stationary plans are not sufficient for optimality. Quite surprisingly we show that when an adversary chooses the stopping-time distribution with expected stopping-time T, then stationary plans are sufficient. While computing optimal stationary plans for fixed horizon is NP-complete, we show that computing optimal stationary plans under adversarial stopping-time distribution can be achieved in polynomial time.","lang":"eng"}],"project":[{"name":"Game Theory","grant_number":"S11407","_id":"25863FF4-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"name":"Formal Methods for Stochastic Models: Algorithms and Applications","call_identifier":"H2020","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","grant_number":"863818"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"type":"journal_article","volume":129,"page":"1-21","day":"01","publisher":"Elsevier","related_material":{"record":[{"relation":"earlier_version","id":"7402","status":"public"}]},"article_type":"original","_id":"11402","scopus_import":"1","quality_controlled":"1","title":"Graph planning with expected finite horizon","oa_version":"Preprint","external_id":{"isi":["000805002800001"],"arxiv":["1802.03642"]},"doi":"10.1016/j.jcss.2022.04.003","acknowledgement":"This work was partially supported by Austrian Science Fund (FWF) NFN Grant No RiSE/SHiNE S11407 and by the grant ERC CoG 863818 (ForM-SMArt).","publication":"Journal of Computer and System Sciences","article_processing_charge":"No","date_published":"2022-11-01T00:00:00Z","main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.1802.03642"}],"ec_funded":1,"publication_status":"published","department":[{"_id":"KrCh"}],"arxiv":1,"isi":1,"date_created":"2022-05-22T22:01:40Z","publication_identifier":{"eissn":["1090-2724"],"issn":["0022-0000"]},"intvolume":" 129","author":[{"first_name":"Krishnendu","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Doyen, Laurent","last_name":"Doyen","first_name":"Laurent"}],"year":"2022","month":"11","status":"public"},{"date_published":"2022-06-01T00:00:00Z","corr_author":"1","department":[{"_id":"GradSch"}],"publication_status":"published","author":[{"full_name":"Stöllner, Andrea","id":"4bdcf7f6-eb97-11eb-a6c2-9981bbdc3bed","orcid":"0000-0002-0464-8440","last_name":"Stöllner","first_name":"Andrea"}],"publication_identifier":{"eissn":["2662-138X"]},"intvolume":" 3","date_created":"2022-05-22T22:01:41Z","isi":1,"status":"public","month":"06","year":"2022","title":"Measuring airborne nanoplastics using aerosol physics","quality_controlled":"1","scopus_import":"1","doi":"10.1038/s43017-022-00302-y","oa_version":"None","external_id":{"isi":["000791125600002"]},"publication":"Nature Reviews Earth and Environment","article_processing_charge":"No","page":"360","publisher":"Springer Nature","day":"01","_id":"11403","article_type":"original","issue":"6","citation":{"ista":"Stöllner A. 2022. Measuring airborne nanoplastics using aerosol physics. Nature Reviews Earth and Environment. 3(6), 360.","apa":"Stöllner, A. (2022). Measuring airborne nanoplastics using aerosol physics. Nature Reviews Earth and Environment. Springer Nature. https://doi.org/10.1038/s43017-022-00302-y","chicago":"Stöllner, Andrea. “Measuring Airborne Nanoplastics Using Aerosol Physics.” Nature Reviews Earth and Environment. Springer Nature, 2022. https://doi.org/10.1038/s43017-022-00302-y.","ieee":"A. Stöllner, “Measuring airborne nanoplastics using aerosol physics,” Nature Reviews Earth and Environment, vol. 3, no. 6. Springer Nature, p. 360, 2022.","short":"A. Stöllner, Nature Reviews Earth and Environment 3 (2022) 360.","ama":"Stöllner A. Measuring airborne nanoplastics using aerosol physics. Nature Reviews Earth and Environment. 2022;3(6):360. doi:10.1038/s43017-022-00302-y","mla":"Stöllner, Andrea. “Measuring Airborne Nanoplastics Using Aerosol Physics.” Nature Reviews Earth and Environment, vol. 3, no. 6, Springer Nature, 2022, p. 360, doi:10.1038/s43017-022-00302-y."},"language":[{"iso":"eng"}],"date_updated":"2024-10-09T21:02:28Z","volume":3,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"issue":"19","article_number":"190401","citation":{"short":"A.J. Sigillito, J.P. Covey, J.M. Fink, K. Petersson, S. Preble, Applied Physics Letters 120 (2022).","ama":"Sigillito AJ, Covey JP, Fink JM, Petersson K, Preble S. Emerging qubit systems: Guest editorial. Applied Physics Letters. 2022;120(19). doi:10.1063/5.0097339","mla":"Sigillito, Anthony J., et al. “Emerging Qubit Systems: Guest Editorial.” Applied Physics Letters, vol. 120, no. 19, 190401, American Institute of Physics, 2022, doi:10.1063/5.0097339.","ista":"Sigillito AJ, Covey JP, Fink JM, Petersson K, Preble S. 2022. Emerging qubit systems: Guest editorial. Applied Physics Letters. 120(19), 190401.","apa":"Sigillito, A. J., Covey, J. P., Fink, J. M., Petersson, K., & Preble, S. (2022). Emerging qubit systems: Guest editorial. Applied Physics Letters. American Institute of Physics. https://doi.org/10.1063/5.0097339","chicago":"Sigillito, Anthony J., Jacob P. Covey, Johannes M Fink, Karl Petersson, and Stefan Preble. “Emerging Qubit Systems: Guest Editorial.” Applied Physics Letters. American Institute of Physics, 2022. https://doi.org/10.1063/5.0097339.","ieee":"A. J. Sigillito, J. P. Covey, J. M. Fink, K. Petersson, and S. Preble, “Emerging qubit systems: Guest editorial,” Applied Physics Letters, vol. 120, no. 19. American Institute of Physics, 2022."},"date_updated":"2023-08-03T07:16:20Z","abstract":[{"lang":"eng","text":"Over the past few years, the field of quantum information science has seen tremendous progress toward realizing large-scale quantum computers. With demonstrations of quantum computers outperforming classical computers for a select range of problems,1–3 we have finally entered the noisy, intermediate-scale quantum (NISQ) computing era. While the quantum computers of today are technological marvels, they are not yet error corrected, and it is unclear whether any system will scale beyond a few hundred logical qubits without significant changes to architecture and control schemes. Today's quantum systems are analogous to the ENIAC (Electronic Numerical Integrator And Computer) and EDVAC (Electronic Discrete Variable Automatic Computer) systems of the 1940s, which ran on vacuum tubes. These machines were built on a solid, nominally scalable architecture and when they were developed, nobody could have predicted the development of the transistor and the impact of the resulting semiconductor industry. Simply put, the computers of today are nothing like the early computers of the 1940s. We believe that the qubits of future fault-tolerant quantum systems will look quite different from the qubits of the NISQ machines in operation today. This Special Topic issue is devoted to new and emerging quantum systems with a focus on enabling technologies that can eventually lead to the quantum analog to the transistor. We have solicited both research4–18 and perspective articles19–21 to discuss new and emerging qubit systems with a focus on novel materials, encodings, and architectures. We are proud to present a collection that touches on a wide range of technologies including superconductors,7–13,21 semiconductors,15–17,19 and individual atomic qubits.18\r\n"}],"language":[{"iso":"eng"}],"oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","type":"journal_article","volume":120,"day":"12","publisher":"American Institute of Physics","_id":"11417","article_type":"letter_note","scopus_import":"1","title":"Emerging qubit systems: Guest editorial","quality_controlled":"1","doi":"10.1063/5.0097339","external_id":{"isi":["000796002100002"]},"oa_version":"Published Version","acknowledgement":"We would like to thank all of the authors who contributed to\r\nthis Special Topic. We would also like to thank the editorial team at\r\nAPL including Jessica Trudeau, Emma Van Burns, Martin Weides,\r\nand Lesley Cohen.","publication":"Applied Physics Letters","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1063/5.0097339"}],"date_published":"2022-05-12T00:00:00Z","publication_status":"published","department":[{"_id":"JoFi"}],"date_created":"2022-05-29T22:01:53Z","isi":1,"author":[{"first_name":"Anthony J.","last_name":"Sigillito","full_name":"Sigillito, Anthony J."},{"full_name":"Covey, Jacob P.","first_name":"Jacob P.","last_name":"Covey"},{"last_name":"Fink","first_name":"Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","full_name":"Fink, Johannes M","orcid":"0000-0001-8112-028X"},{"full_name":"Petersson, Karl","last_name":"Petersson","first_name":"Karl"},{"full_name":"Preble, Stefan","first_name":"Stefan","last_name":"Preble"}],"intvolume":" 120","publication_identifier":{"issn":["0003-6951"]},"year":"2022","status":"public","month":"05"},{"article_type":"original","_id":"11418","day":"01","publisher":"Institute of Mathematical Statistics","page":"984-1012","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"type":"journal_article","volume":50,"date_updated":"2023-08-03T07:16:53Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We consider the quadratic form of a general high-rank deterministic matrix on the eigenvectors of an N×N\r\nWigner matrix and prove that it has Gaussian fluctuation for each bulk eigenvector in the large N limit. The proof is a combination of the energy method for the Dyson Brownian motion inspired by Marcinek and Yau (2021) and our recent multiresolvent local laws (Comm. Math. Phys. 388 (2021) 1005–1048)."}],"citation":{"ista":"Cipolloni G, Erdös L, Schröder DJ. 2022. Normal fluctuation in quantum ergodicity for Wigner matrices. Annals of Probability. 50(3), 984–1012.","apa":"Cipolloni, G., Erdös, L., & Schröder, D. J. (2022). Normal fluctuation in quantum ergodicity for Wigner matrices. Annals of Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/21-AOP1552","ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “Normal fluctuation in quantum ergodicity for Wigner matrices,” Annals of Probability, vol. 50, no. 3. Institute of Mathematical Statistics, pp. 984–1012, 2022.","chicago":"Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Normal Fluctuation in Quantum Ergodicity for Wigner Matrices.” Annals of Probability. Institute of Mathematical Statistics, 2022. https://doi.org/10.1214/21-AOP1552.","short":"G. Cipolloni, L. Erdös, D.J. Schröder, Annals of Probability 50 (2022) 984–1012.","ama":"Cipolloni G, Erdös L, Schröder DJ. Normal fluctuation in quantum ergodicity for Wigner matrices. Annals of Probability. 2022;50(3):984-1012. doi:10.1214/21-AOP1552","mla":"Cipolloni, Giorgio, et al. “Normal Fluctuation in Quantum Ergodicity for Wigner Matrices.” Annals of Probability, vol. 50, no. 3, Institute of Mathematical Statistics, 2022, pp. 984–1012, doi:10.1214/21-AOP1552."},"issue":"3","year":"2022","month":"05","status":"public","arxiv":1,"isi":1,"date_created":"2022-05-29T22:01:53Z","intvolume":" 50","publication_identifier":{"eissn":["2168-894X"],"issn":["0091-1798"]},"author":[{"last_name":"Cipolloni","first_name":"Giorgio","full_name":"Cipolloni, Giorgio","id":"42198EFA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4901-7992"},{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László"},{"first_name":"Dominik J","last_name":"Schröder","orcid":"0000-0002-2904-1856","id":"408ED176-F248-11E8-B48F-1D18A9856A87","full_name":"Schröder, Dominik J"}],"publication_status":"published","department":[{"_id":"LaEr"}],"date_published":"2022-05-01T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2103.06730"}],"article_processing_charge":"No","acknowledgement":"L.E. would like to thank Zhigang Bao for many illuminating discussions in an early stage of this research. The authors are also grateful to Paul Bourgade for his comments on the manuscript and the anonymous referee for several useful suggestions.","publication":"Annals of Probability","external_id":{"arxiv":["2103.06730"],"isi":["000793963400005"]},"oa_version":"Preprint","doi":"10.1214/21-AOP1552","scopus_import":"1","quality_controlled":"1","title":"Normal fluctuation in quantum ergodicity for Wigner matrices"},{"publication_status":"published","department":[{"_id":"RySh"}],"date_published":"2022-05-05T00:00:00Z","year":"2022","month":"05","status":"public","date_created":"2022-05-29T22:01:54Z","isi":1,"intvolume":" 11","publication_identifier":{"eissn":["2050-084X"]},"author":[{"last_name":"Hori","first_name":"Tetsuya","full_name":"Hori, Tetsuya"},{"full_name":"Eguchi, Kohgaku","id":"2B7846DC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6170-2546","last_name":"Eguchi","first_name":"Kohgaku"},{"full_name":"Wang, Han Ying","last_name":"Wang","first_name":"Han Ying"},{"full_name":"Miyasaka, Tomohiro","last_name":"Miyasaka","first_name":"Tomohiro"},{"full_name":"Guillaud, Laurent","last_name":"Guillaud","first_name":"Laurent"},{"full_name":"Taoufiq, Zacharie","last_name":"Taoufiq","first_name":"Zacharie"},{"first_name":"Satyajit","last_name":"Mahapatra","full_name":"Mahapatra, Satyajit"},{"full_name":"Yamada, Hiroshi","last_name":"Yamada","first_name":"Hiroshi"},{"full_name":"Takei, Kohji","first_name":"Kohji","last_name":"Takei"},{"full_name":"Takahashi, Tomoyuki","first_name":"Tomoyuki","last_name":"Takahashi"}],"file":[{"date_created":"2022-05-30T08:09:16Z","date_updated":"2022-05-30T08:09:16Z","access_level":"open_access","file_name":"elife-73542-v2.pdf","checksum":"ccddbd167e00ff8375f12998af497152","success":1,"file_size":2466296,"content_type":"application/pdf","creator":"cchlebak","file_id":"11421","relation":"main_file"}],"ddc":["616"],"external_id":{"pmid":["35471147 "],"isi":["000876231600001"]},"oa_version":"Published Version","doi":"10.7554/eLife.73542","file_date_updated":"2022-05-30T08:09:16Z","scopus_import":"1","quality_controlled":"1","title":"Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer's disease synapse model","article_processing_charge":"No","acknowledgement":"We thank Yasuo Ihara, Nobuyuki Nukina, and Takeshi Sakaba for comments and Patrick Stoney for editing this paper. We also thank Shota Okuda and Mikako Matsubara for their contributions in the early stage of this study, and Satoko Wada-Kakuda for technical assistant with in vitro analysis of tau. This research was supported by funding from Okinawa Institute of Science and Technology and from Technology (OIST) and Core Research for the Evolutional Science and Technology of Japan Science and Technology Agency (CREST) to TT, and by Scientific Research on Innovative Areas to TM (Brain Protein Aging and Dementia Control 26117004).","publication":"eLife","pmid":1,"_id":"11419","article_type":"original","day":"05","publisher":"eLife Sciences Publications","citation":{"mla":"Hori, Tetsuya, et al. “Microtubule Assembly by Tau Impairs Endocytosis and Neurotransmission via Dynamin Sequestration in Alzheimer’s Disease Synapse Model.” ELife, vol. 11, e73542, eLife Sciences Publications, 2022, doi:10.7554/eLife.73542.","ama":"Hori T, Eguchi K, Wang HY, et al. Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model. eLife. 2022;11. doi:10.7554/eLife.73542","short":"T. Hori, K. Eguchi, H.Y. Wang, T. Miyasaka, L. Guillaud, Z. Taoufiq, S. Mahapatra, H. Yamada, K. Takei, T. Takahashi, ELife 11 (2022).","chicago":"Hori, Tetsuya, Kohgaku Eguchi, Han Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, and Tomoyuki Takahashi. “Microtubule Assembly by Tau Impairs Endocytosis and Neurotransmission via Dynamin Sequestration in Alzheimer’s Disease Synapse Model.” ELife. eLife Sciences Publications, 2022. https://doi.org/10.7554/eLife.73542.","ieee":"T. Hori et al., “Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model,” eLife, vol. 11. eLife Sciences Publications, 2022.","apa":"Hori, T., Eguchi, K., Wang, H. Y., Miyasaka, T., Guillaud, L., Taoufiq, Z., … Takahashi, T. (2022). Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.73542","ista":"Hori T, Eguchi K, Wang HY, Miyasaka T, Guillaud L, Taoufiq Z, Mahapatra S, Yamada H, Takei K, Takahashi T. 2022. Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model. eLife. 11, e73542."},"article_number":"e73542","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"volume":11,"type":"journal_article","date_updated":"2023-08-03T07:15:49Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer’s disease. We addressed whether tau elevation affects synaptic transmission at the calyx of Held in slices from mice brainstem. Whole-cell loading of WT human tau (h-tau) in presynaptic terminals at 10–20 µM caused microtubule (MT) assembly and activity-dependent rundown of excitatory neurotransmission. Capacitance measurements revealed that the primary target of WT h-tau is vesicle endocytosis. Blocking MT assembly using nocodazole prevented tau-induced impairments of endocytosis and neurotransmission. Immunofluorescence imaging analyses revealed that MT assembly by WT h-tau loading was associated with an increased MT-bound fraction of the endocytic protein dynamin. A synthetic dodecapeptide corresponding to dynamin 1-pleckstrin-homology domain inhibited MT-dynamin interaction and rescued tau-induced impairments of endocytosis and neurotransmission. We conclude that elevation of presynaptic WT tau induces de novo assembly of MTs, thereby sequestering free dynamins. As a result, endocytosis and subsequent vesicle replenishment are impaired, causing activity-dependent rundown of neurotransmission."}]},{"publication":"38th International Symposium on Computational Geometry","acknowledgement":"Partially supported by the DFG Collaborative Research Center TRR 109, “Discretization in Geometry and Dynamics” and the European Research Council (ERC), grant no. 788183, “Alpha Shape Theory Extended”. Erin Chambers: Supported in part by the National Science Foundation through grants DBI-1759807, CCF-1907612, and CCF-2106672. Mathijs Wintraecken: Supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754411. The Austrian science fund (FWF) M-3073 Acknowledgements We thank André Lieutier, David Letscher, Ellen Gasparovic, Kathryn Leonard, and Tao Ju for early discussions on this work. We also thank Lu Liu, Yajie Yan and Tao Ju for sharing code to generate the examples.","article_processing_charge":"No","title":"A cautionary tale: Burning the medial axis is unstable","quality_controlled":"1","scopus_import":"1","file_date_updated":"2022-06-07T07:58:30Z","doi":"10.4230/LIPIcs.SoCG.2022.66","oa_version":"Published Version","ddc":["510"],"file":[{"content_type":"application/pdf","file_id":"11437","creator":"dernst","file_size":17580705,"success":1,"checksum":"b25ce40fade4ebc0bcaae176db4f5f1f","file_name":"2022_LIPICs_Chambers.pdf","access_level":"open_access","date_updated":"2022-06-07T07:58:30Z","date_created":"2022-06-07T07:58:30Z","relation":"main_file"}],"author":[{"full_name":"Chambers, Erin","first_name":"Erin","last_name":"Chambers"},{"full_name":"Fillmore, Christopher D","id":"35638A5C-AAC7-11E9-B0BF-5503E6697425","last_name":"Fillmore","first_name":"Christopher D"},{"id":"2D04F932-F248-11E8-B48F-1D18A9856A87","full_name":"Stephenson, Elizabeth R","orcid":"0000-0002-6862-208X","last_name":"Stephenson","first_name":"Elizabeth R"},{"first_name":"Mathijs","last_name":"Wintraecken","orcid":"0000-0002-7472-2220","id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","full_name":"Wintraecken, Mathijs"}],"publication_identifier":{"issn":["1868-8969"],"isbn":["978-3-95977-227-3"]},"intvolume":" 224","date_created":"2022-06-01T14:18:04Z","status":"public","month":"06","year":"2022","ec_funded":1,"date_published":"2022-06-01T00:00:00Z","series_title":"LIPIcs","corr_author":"1","editor":[{"full_name":"Goaoc, Xavier","first_name":"Xavier","last_name":"Goaoc"},{"full_name":"Kerber, Michael","last_name":"Kerber","first_name":"Michael"}],"department":[{"_id":"HeEd"}],"publication_status":"published","abstract":[{"text":"The medial axis of a set consists of the points in the ambient space without a unique closest point on the original set. Since its introduction, the medial axis has been used extensively in many applications as a method of computing a topologically equivalent skeleton. Unfortunately, one limiting factor in the use of the medial axis of a smooth manifold is that it is not necessarily topologically stable under small perturbations of the manifold. To counter these instabilities various prunings of the medial axis have been proposed. Here, we examine one type of pruning, called burning. Because of the good experimental results, it was hoped that the burning method of simplifying the medial axis would be stable. In this work we show a simple example that dashes such hopes based on Bing’s house with two rooms, demonstrating an isotopy of a shape where the medial axis goes from collapsible to non-collapsible.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2025-04-14T07:43:57Z","volume":224,"type":"conference","oa":1,"project":[{"grant_number":"M03073","_id":"fc390959-9c52-11eb-aca3-afa58bd282b2","name":"Learning and triangulating manifolds via collapses"},{"name":"Alpha Shape Theory Extended","call_identifier":"H2020","grant_number":"788183","_id":"266A2E9E-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","conference":{"end_date":"2022-06-10","name":"SoCG: Symposium on Computational Geometry","location":"Berlin, Germany","start_date":"2022-06-07"},"citation":{"ista":"Chambers E, Fillmore CD, Stephenson ER, Wintraecken M. 2022. A cautionary tale: Burning the medial axis is unstable. 38th International Symposium on Computational Geometry. SoCG: Symposium on Computational GeometryLIPIcs vol. 224, 66:1-66:9.","chicago":"Chambers, Erin, Christopher D Fillmore, Elizabeth R Stephenson, and Mathijs Wintraecken. “A Cautionary Tale: Burning the Medial Axis Is Unstable.” In 38th International Symposium on Computational Geometry, edited by Xavier Goaoc and Michael Kerber, 224:66:1-66:9. LIPIcs. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022. https://doi.org/10.4230/LIPIcs.SoCG.2022.66.","ieee":"E. Chambers, C. D. Fillmore, E. R. Stephenson, and M. Wintraecken, “A cautionary tale: Burning the medial axis is unstable,” in 38th International Symposium on Computational Geometry, Berlin, Germany, 2022, vol. 224, p. 66:1-66:9.","apa":"Chambers, E., Fillmore, C. D., Stephenson, E. R., & Wintraecken, M. (2022). A cautionary tale: Burning the medial axis is unstable. In X. Goaoc & M. Kerber (Eds.), 38th International Symposium on Computational Geometry (Vol. 224, p. 66:1-66:9). Berlin, Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.SoCG.2022.66","ama":"Chambers E, Fillmore CD, Stephenson ER, Wintraecken M. A cautionary tale: Burning the medial axis is unstable. In: Goaoc X, Kerber M, eds. 38th International Symposium on Computational Geometry. Vol 224. LIPIcs. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2022:66:1-66:9. doi:10.4230/LIPIcs.SoCG.2022.66","short":"E. Chambers, C.D. Fillmore, E.R. Stephenson, M. Wintraecken, in:, X. Goaoc, M. Kerber (Eds.), 38th International Symposium on Computational Geometry, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022, p. 66:1-66:9.","mla":"Chambers, Erin, et al. “A Cautionary Tale: Burning the Medial Axis Is Unstable.” 38th International Symposium on Computational Geometry, edited by Xavier Goaoc and Michael Kerber, vol. 224, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022, p. 66:1-66:9, doi:10.4230/LIPIcs.SoCG.2022.66."},"day":"01","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","_id":"11428","page":"66:1-66:9"},{"title":"Web and Wireless Geographical Information Systems","quality_controlled":"1","edition":"1","alternative_title":["LNCS"],"citation":{"ista":"Karimipour F, Storandt S eds. 2022. Web and Wireless Geographical Information Systems 1st ed., Cham: Springer Nature, 153p.","ieee":"F. Karimipour and S. Storandt, Eds., Web and Wireless Geographical Information Systems, 1st ed., vol. 13238. Cham: Springer Nature, 2022.","chicago":"Karimipour, Farid, and Sabine Storandt, eds. Web and Wireless Geographical Information Systems. 1st ed. Vol. 13238. Cham: Springer Nature, 2022. https://doi.org/10.1007/978-3-031-06245-2.","apa":"Karimipour, F., & Storandt, S. (Eds.). (2022). Web and Wireless Geographical Information Systems (1st ed., Vol. 13238). Cham: Springer Nature. https://doi.org/10.1007/978-3-031-06245-2","ama":"Karimipour F, Storandt S, eds. Web and Wireless Geographical Information Systems. Vol 13238. 1st ed. Cham: Springer Nature; 2022. doi:10.1007/978-3-031-06245-2","short":"F. Karimipour, S. Storandt, eds., Web and Wireless Geographical Information Systems, 1st ed., Springer Nature, Cham, 2022.","mla":"Karimipour, Farid, and Sabine Storandt, editors. Web and Wireless Geographical Information Systems. 1st ed., vol. 13238, Springer Nature, 2022, doi:10.1007/978-3-031-06245-2."},"doi":"10.1007/978-3-031-06245-2","oa_version":"None","abstract":[{"text":"This book constitutes the refereed proceedings of the 18th International Symposium on Web and Wireless Geographical Information Systems, W2GIS 2022, held in Konstanz, Germany, in April 2022.\r\nThe 7 full papers presented together with 6 short papers in the volume were carefully reviewed and selected from 16 submissions. The papers cover topics that range from mobile GIS and Location-Based Services to Spatial Information Retrieval and Wireless Sensor Networks.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2024-10-09T21:02:30Z","article_processing_charge":"No","volume":13238,"type":"book_editor","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2022-05-01T00:00:00Z","corr_author":"1","editor":[{"last_name":"Karimipour","first_name":"Farid","full_name":"Karimipour, Farid","id":"2A2BCDC4-CF62-11E9-BE5E-3B1EE6697425","orcid":"0000-0001-6746-4174"},{"last_name":"Storandt","first_name":"Sabine","full_name":"Storandt, Sabine"}],"department":[{"_id":"HeEd"}],"publication_status":"published","page":"153","publication_identifier":{"eisbn":["9783031062452"],"isbn":["9783031062445"],"issn":["0302-9743"],"eissn":["1611-3349"]},"intvolume":" 13238","date_created":"2022-06-02T05:40:53Z","day":"01","publisher":"Springer Nature","status":"public","month":"05","_id":"11429","place":"Cham","year":"2022"}]