[{"publication_status":"published","file_date_updated":"2023-06-19T10:41:05Z","ec_funded":1,"language":[{"iso":"eng"}],"corr_author":"1","abstract":[{"text":"We investigate fast and communication-efficient algorithms for the classic problem of minimizing a sum of strongly convex and smooth functions that are distributed among n\r\n different nodes, which can communicate using a limited number of bits. Most previous communication-efficient approaches for this problem are limited to first-order optimization, and therefore have \\emph{linear} dependence on the condition number in their communication complexity. We show that this dependence is not inherent: communication-efficient methods can in fact have sublinear dependence on the condition number. For this, we design and analyze the first communication-efficient distributed variants of preconditioned gradient descent for Generalized Linear Models, and for Newton’s method. Our results rely on a new technique for quantizing both the preconditioner and the descent direction at each step of the algorithms, while controlling their convergence rate. We also validate our findings experimentally, showing faster convergence and reduced communication relative to previous methods.","lang":"eng"}],"day":"01","conference":{"location":"Virtual","name":"ICML: International Conference on Machine Learning","end_date":"2021-07-24","start_date":"2021-07-18"},"oa":1,"title":"Communication-efficient distributed optimization with quantized preconditioners","volume":139,"year":"2021","article_processing_charge":"No","ddc":["000"],"scopus_import":"1","date_updated":"2025-07-10T11:50:37Z","type":"conference","publication":"Proceedings of the 38th International Conference on Machine Learning","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Foivos","last_name":"Alimisis","full_name":"Alimisis, Foivos"},{"first_name":"Peter","last_name":"Davies","full_name":"Davies, Peter","id":"11396234-BB50-11E9-B24C-90FCE5697425","orcid":"0000-0002-5646-9524"},{"first_name":"Dan-Adrian","last_name":"Alistarh","full_name":"Alistarh, Dan-Adrian","orcid":"0000-0003-3650-940X","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87"}],"arxiv":1,"external_id":{"arxiv":["2102.07214"]},"acknowledgement":"The authors would like to thank Janne Korhonen, Aurelien Lucchi, Celestine MendlerDunner and Antonio Orvieto for helpful discussions. FA ¨and DA were supported during this work by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 805223 ScaleML). PD was supported by the European Union’s Horizon 2020 programme under the Marie Skłodowska-Curie grant agreement No. 754411.","has_accepted_license":"1","file":[{"file_size":429087,"checksum":"7ec0d59bac268b49c76bf2e036dedd7a","success":1,"file_name":"2021_PMLR_Alimisis.pdf","date_created":"2023-06-19T10:41:05Z","relation":"main_file","access_level":"open_access","creator":"dernst","content_type":"application/pdf","file_id":"13154","date_updated":"2023-06-19T10:41:05Z"}],"status":"public","month":"07","page":"196-206","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_created":"2023-06-18T22:00:48Z","department":[{"_id":"DaAl"}],"citation":{"ama":"Alimisis F, Davies P, Alistarh D-A. Communication-efficient distributed optimization with quantized preconditioners. In: Proceedings of the 38th International Conference on Machine Learning. Vol 139. ML Research Press; 2021:196-206.","apa":"Alimisis, F., Davies, P., & Alistarh, D.-A. (2021). Communication-efficient distributed optimization with quantized preconditioners. In Proceedings of the 38th International Conference on Machine Learning (Vol. 139, pp. 196–206). Virtual: ML Research Press.","ieee":"F. Alimisis, P. Davies, and D.-A. Alistarh, “Communication-efficient distributed optimization with quantized preconditioners,” in Proceedings of the 38th International Conference on Machine Learning, Virtual, 2021, vol. 139, pp. 196–206.","ista":"Alimisis F, Davies P, Alistarh D-A. 2021. Communication-efficient distributed optimization with quantized preconditioners. Proceedings of the 38th International Conference on Machine Learning. ICML: International Conference on Machine Learning vol. 139, 196–206.","mla":"Alimisis, Foivos, et al. “Communication-Efficient Distributed Optimization with Quantized Preconditioners.” Proceedings of the 38th International Conference on Machine Learning, vol. 139, ML Research Press, 2021, pp. 196–206.","short":"F. Alimisis, P. Davies, D.-A. Alistarh, in:, Proceedings of the 38th International Conference on Machine Learning, ML Research Press, 2021, pp. 196–206.","chicago":"Alimisis, Foivos, Peter Davies, and Dan-Adrian Alistarh. “Communication-Efficient Distributed Optimization with Quantized Preconditioners.” In Proceedings of the 38th International Conference on Machine Learning, 139:196–206. ML Research Press, 2021."},"publisher":"ML Research Press","intvolume":" 139","publication_identifier":{"eissn":["2640-3498"],"isbn":["9781713845065"]},"_id":"13147","quality_controlled":"1","project":[{"_id":"268A44D6-B435-11E9-9278-68D0E5697425","name":"Elastic Coordination for Scalable Machine Learning","call_identifier":"H2020","grant_number":"805223"},{"call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"}],"date_published":"2021-07-01T00:00:00Z"},{"intvolume":" 1505","publication_identifier":{"issn":["0077-8923"],"eissn":["1749-6632"]},"issue":"1","_id":"13356","date_published":"2021-12-01T00:00:00Z","quality_controlled":"1","page":"191-201","status":"public","month":"12","citation":{"ieee":"T. Bian and R. Klajn, “Morphology control in crystalline nanoparticle–polymer aggregates,” Annals of the New York Academy of Sciences, vol. 1505, no. 1. Wiley, pp. 191–201, 2021.","ama":"Bian T, Klajn R. Morphology control in crystalline nanoparticle–polymer aggregates. Annals of the New York Academy of Sciences. 2021;1505(1):191-201. doi:10.1111/nyas.14674","apa":"Bian, T., & Klajn, R. (2021). Morphology control in crystalline nanoparticle–polymer aggregates. Annals of the New York Academy of Sciences. Wiley. https://doi.org/10.1111/nyas.14674","short":"T. Bian, R. Klajn, Annals of the New York Academy of Sciences 1505 (2021) 191–201.","mla":"Bian, Tong, and Rafal Klajn. “Morphology Control in Crystalline Nanoparticle–Polymer Aggregates.” Annals of the New York Academy of Sciences, vol. 1505, no. 1, Wiley, 2021, pp. 191–201, doi:10.1111/nyas.14674.","ista":"Bian T, Klajn R. 2021. Morphology control in crystalline nanoparticle–polymer aggregates. Annals of the New York Academy of Sciences. 1505(1), 191–201.","chicago":"Bian, Tong, and Rafal Klajn. “Morphology Control in Crystalline Nanoparticle–Polymer Aggregates.” Annals of the New York Academy of Sciences. Wiley, 2021. https://doi.org/10.1111/nyas.14674."},"publisher":"Wiley","date_created":"2023-08-01T09:33:39Z","keyword":["History and Philosophy of Science","General Biochemistry","Genetics and Molecular Biology","General Neuroscience"],"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"author":[{"full_name":"Bian, Tong","first_name":"Tong","last_name":"Bian"},{"last_name":"Klajn","first_name":"Rafal","id":"8e84690e-1e48-11ed-a02b-a1e6fb8bb53b","full_name":"Klajn, Rafal"}],"external_id":{"pmid":["34427923"]},"ddc":["540"],"scopus_import":"1","date_updated":"2024-10-14T12:12:06Z","publication":"Annals of the New York Academy of Sciences","type":"journal_article","article_type":"original","article_processing_charge":"No","abstract":[{"text":"Self-assembly of nanoparticles can be mediated by polymers, but has so far led almost exclusively to nanoparticle aggregates that are amorphous. Here, we employed Coulombic interactions to generate a range of composite materials from mixtures of charged nanoparticles and oppositely charged polymers. The assembly behavior of these nanoparticle/polymer composites depends on their order of addition: polymers added to nanoparticles give rise to stable aggregates, but nanoparticles added to polymers disassemble the initially formed aggregates. The amorphous aggregates were transformed into crystalline ones by transiently increasing the ionic strength of the solution. The morphology of the resulting crystals depended on the length of the polymer: short polymer chains mediated the self-assembly of nanoparticles into strongly faceted crystals, whereas long chains led to pseudospherical nanoparticle/polymer assemblies, within which the crystalline order of nanoparticles was retained.","lang":"eng"}],"language":[{"iso":"eng"}],"title":"Morphology control in crystalline nanoparticle–polymer aggregates","volume":1505,"year":"2021","day":"01","oa":1,"extern":"1","publication_status":"published","doi":"10.1111/nyas.14674","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1111/nyas.14674"}]},{"article_processing_charge":"No","article_type":"original","scopus_import":"1","date_updated":"2025-06-26T11:49:07Z","publication":"Nature Physics","type":"journal_article","doi":"10.1038/s41567-021-01334-9","publication_status":"published","language":[{"iso":"eng"}],"abstract":[{"text":"Most water in the Universe may be superionic, and its thermodynamic and transport properties are crucial for planetary science but difficult to probe experimentally or theoretically. We use machine learning and free-energy methods to overcome the limitations of quantum mechanical simulations and characterize hydrogen diffusion, superionic transitions and phase behaviours of water at extreme conditions. We predict that close-packed superionic phases, which have a fraction of mixed stacking for finite systems, are stable over a wide temperature and pressure range, whereas a body-centred cubic superionic phase is only thermodynamically stable in a small window but is kinetically favoured. Our phase boundaries, which are consistent with existing—albeit scarce—experimental observations, help resolve the fractions of insulating ice, different superionic phases and liquid water inside ice giants.","lang":"eng"}],"day":"01","OA_type":"green","extern":"1","volume":17,"title":"Phase behaviours of superionic water at planetary conditions","year":"2021","status":"public","month":"11","page":"1228-1232","date_created":"2025-06-26T11:36:36Z","publisher":"Springer Nature","citation":{"ieee":"B. Cheng, M. Bethkenhagen, C. J. Pickard, and S. Hamel, “Phase behaviours of superionic water at planetary conditions,” Nature Physics, vol. 17, no. 11. Springer Nature, pp. 1228–1232, 2021.","apa":"Cheng, B., Bethkenhagen, M., Pickard, C. J., & Hamel, S. (2021). Phase behaviours of superionic water at planetary conditions. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-021-01334-9","ama":"Cheng B, Bethkenhagen M, Pickard CJ, Hamel S. Phase behaviours of superionic water at planetary conditions. Nature Physics. 2021;17(11):1228-1232. doi:10.1038/s41567-021-01334-9","mla":"Cheng, Bingqing, et al. “Phase Behaviours of Superionic Water at Planetary Conditions.” Nature Physics, vol. 17, no. 11, Springer Nature, 2021, pp. 1228–32, doi:10.1038/s41567-021-01334-9.","short":"B. Cheng, M. Bethkenhagen, C.J. Pickard, S. Hamel, Nature Physics 17 (2021) 1228–1232.","ista":"Cheng B, Bethkenhagen M, Pickard CJ, Hamel S. 2021. Phase behaviours of superionic water at planetary conditions. Nature Physics. 17(11), 1228–1232.","chicago":"Cheng, Bingqing, Mandy Bethkenhagen, Chris J. Pickard, and Sebastien Hamel. “Phase Behaviours of Superionic Water at Planetary Conditions.” Nature Physics. Springer Nature, 2021. https://doi.org/10.1038/s41567-021-01334-9."},"intvolume":" 17","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"issue":"11","_id":"19909","quality_controlled":"1","date_published":"2021-11-01T00:00:00Z","related_material":{"record":[{"status":"public","id":"9696","relation":"earlier_version"}]},"oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"repository","author":[{"first_name":"Bingqing","last_name":"Cheng","orcid":"0000-0002-3584-9632","full_name":"Cheng, Bingqing","id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9"},{"full_name":"Bethkenhagen, Mandy","first_name":"Mandy","last_name":"Bethkenhagen"},{"full_name":"Pickard, Chris J.","first_name":"Chris J.","last_name":"Pickard"},{"full_name":"Hamel, Sebastien","first_name":"Sebastien","last_name":"Hamel"}],"arxiv":1,"external_id":{"arxiv":["2103.09035"]}},{"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"The first author’s previous work established Solomon’s WDVV-type relations for Welschinger’s invariant curve counts in real symplectic fourfolds by lifting geometric relations over possibly unorientable morphisms. We apply her framework to obtain WDVV-style relations for the disk invariants of real symplectic sixfolds with some symmetry, in particular confirming Alcolado’s prediction for P^3 and extending it to other spaces. These relations reduce the computation of Welschinger’s invariants of many real symplectic sixfolds to invariants in small degrees and provide lower bounds for counts of real rational curves with positive-dimensional insertions in some cases. In the case of P^3, our lower bounds fit perfectly with Kollár’s vanishing results."}],"oa":1,"extern":"1","day":"25","OA_type":"green","year":"2021","title":"WDVV-type relations for disk Gromov–Witten invariants in dimension 6","volume":379,"doi":"10.1007/s00208-020-02130-1","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1904.04254"}],"scopus_import":"1","publication":"Mathematische Annalen","type":"journal_article","date_updated":"2025-11-10T15:11:29Z","article_processing_charge":"No","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","OA_place":"repository","external_id":{"arxiv":["1904.04254"]},"arxiv":1,"author":[{"id":"968ad14a-fd86-11ee-a420-ea29715511a3","full_name":"Chen, Xujia","last_name":"Chen","first_name":"Xujia"},{"full_name":"Zinger, Aleksey","last_name":"Zinger","first_name":"Aleksey"}],"_id":"20619","publication_identifier":{"issn":["0025-5831"],"eissn":["1432-1807"]},"intvolume":" 379","issue":"3-4","quality_controlled":"1","date_published":"2021-01-25T00:00:00Z","month":"01","status":"public","page":"1231-1313","date_created":"2025-11-10T08:41:40Z","publisher":"Springer Nature","citation":{"ista":"Chen X, Zinger A. 2021. WDVV-type relations for disk Gromov–Witten invariants in dimension 6. Mathematische Annalen. 379(3–4), 1231–1313.","short":"X. Chen, A. Zinger, Mathematische Annalen 379 (2021) 1231–1313.","mla":"Chen, Xujia, and Aleksey Zinger. “WDVV-Type Relations for Disk Gromov–Witten Invariants in Dimension 6.” Mathematische Annalen, vol. 379, no. 3–4, Springer Nature, 2021, pp. 1231–313, doi:10.1007/s00208-020-02130-1.","chicago":"Chen, Xujia, and Aleksey Zinger. “WDVV-Type Relations for Disk Gromov–Witten Invariants in Dimension 6.” Mathematische Annalen. Springer Nature, 2021. https://doi.org/10.1007/s00208-020-02130-1.","ama":"Chen X, Zinger A. WDVV-type relations for disk Gromov–Witten invariants in dimension 6. Mathematische Annalen. 2021;379(3-4):1231-1313. doi:10.1007/s00208-020-02130-1","ieee":"X. Chen and A. Zinger, “WDVV-type relations for disk Gromov–Witten invariants in dimension 6,” Mathematische Annalen, vol. 379, no. 3–4. Springer Nature, pp. 1231–1313, 2021.","apa":"Chen, X., & Zinger, A. (2021). WDVV-type relations for disk Gromov–Witten invariants in dimension 6. Mathematische Annalen. Springer Nature. https://doi.org/10.1007/s00208-020-02130-1"}},{"_id":"20622","intvolume":" 61","issue":"2","publication_identifier":{"eissn":["2154-3321"]},"quality_controlled":"1","date_published":"2021-06-01T00:00:00Z","month":"06","status":"public","page":"339-376","date_created":"2025-11-10T08:45:12Z","publisher":"Duke University Press","citation":{"apa":"Chen, X., & Zinger, A. (n.d.). WDVV-type relations for Welschinger’s invariants: Applications. Kyoto Journal of Mathematics. Duke University Press. https://doi.org/10.1215/21562261-2021-0005","ieee":"X. Chen and A. Zinger, “WDVV-type relations for Welschinger’s invariants: Applications,” Kyoto Journal of Mathematics, vol. 61, no. 2. Duke University Press, pp. 339–376.","ama":"Chen X, Zinger A. WDVV-type relations for Welschinger’s invariants: Applications. Kyoto Journal of Mathematics. 61(2):339-376. doi:10.1215/21562261-2021-0005","mla":"Chen, Xujia, and Aleksey Zinger. “WDVV-Type Relations for Welschinger’s Invariants: Applications.” Kyoto Journal of Mathematics, vol. 61, no. 2, Duke University Press, pp. 339–76, doi:10.1215/21562261-2021-0005.","short":"X. Chen, A. Zinger, Kyoto Journal of Mathematics 61 (n.d.) 339–376.","ista":"Chen X, Zinger A. WDVV-type relations for Welschinger’s invariants: Applications. Kyoto Journal of Mathematics. 61(2), 339–376.","chicago":"Chen, Xujia, and Aleksey Zinger. “WDVV-Type Relations for Welschinger’s Invariants: Applications.” Kyoto Journal of Mathematics. Duke University Press, n.d. https://doi.org/10.1215/21562261-2021-0005."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","OA_place":"repository","external_id":{"arxiv":["1809.08938"]},"arxiv":1,"author":[{"id":"968ad14a-fd86-11ee-a420-ea29715511a3","full_name":"Chen, Xujia","first_name":"Xujia","last_name":"Chen"},{"full_name":"Zinger, Aleksey","first_name":"Aleksey","last_name":"Zinger"}],"publication":"Kyoto Journal of Mathematics","type":"journal_article","date_updated":"2025-11-10T15:13:58Z","article_processing_charge":"No","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We first recall Solomon’s relations for Welschinger invariants counting real curves in real symplectic fourfolds and the Witten–Dijkgraaf–Verlinde–Verlinde (WDVV)-style relations for Welschinger invariants counting real curves in real symplectic sixfolds with some symmetry. We then explicitly demonstrate that, in some important cases (projective spaces with standard conjugations, real blowups of the projective plane, and two- and threefold products of the one-dimensional projective space with two involutions each), these relations provide complete recursions determining all Welschinger invariants from basic input. We include extensive tables of Welschinger invariants in low degrees obtained from these recursions with Mathematica. These invariants provide lower bounds for counts of real rational curves, including with curve insertions in smooth algebraic threefolds."}],"oa":1,"extern":"1","OA_type":"green","day":"01","year":"2021","volume":61,"title":"WDVV-type relations for Welschinger's invariants: Applications","doi":"10.1215/21562261-2021-0005","publication_status":"submitted","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1809.08938","open_access":"1"}]},{"_id":"20765","issue":"32","publication_identifier":{"eissn":["1364-548X"],"issn":["1359-7345"]},"intvolume":" 57","date_published":"2021-03-15T00:00:00Z","quality_controlled":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (3.0)","legal_code_url":"https://creativecommons.org/licenses/by/3.0/legalcode","name":"Creative Commons Attribution 3.0 Unported (CC BY 3.0)"},"page":"3909-3912","month":"03","status":"public","publisher":"Royal Society of Chemistry","citation":{"short":"S. Willems, G. Toupalas, J. Reisenbauer, B. Morandi, Chemical Communications 57 (2021) 3909–3912.","mla":"Willems, Suzanne, et al. “A Site-Selective and Stereospecific Cascade Suzuki–Miyaura Annulation of Alkyl 1,2-Bisboronic Esters and 2,2′-Dihalo 1,1′-Biaryls.” Chemical Communications, vol. 57, no. 32, Royal Society of Chemistry, 2021, pp. 3909–12, doi:10.1039/d1cc00648g.","ista":"Willems S, Toupalas G, Reisenbauer J, Morandi B. 2021. A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls. Chemical Communications. 57(32), 3909–3912.","chicago":"Willems, Suzanne, Georgios Toupalas, Julia Reisenbauer, and Bill Morandi. “A Site-Selective and Stereospecific Cascade Suzuki–Miyaura Annulation of Alkyl 1,2-Bisboronic Esters and 2,2′-Dihalo 1,1′-Biaryls.” Chemical Communications. Royal Society of Chemistry, 2021. https://doi.org/10.1039/d1cc00648g.","ieee":"S. Willems, G. Toupalas, J. Reisenbauer, and B. Morandi, “A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls,” Chemical Communications, vol. 57, no. 32. Royal Society of Chemistry, pp. 3909–3912, 2021.","ama":"Willems S, Toupalas G, Reisenbauer J, Morandi B. A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls. Chemical Communications. 2021;57(32):3909-3912. doi:10.1039/d1cc00648g","apa":"Willems, S., Toupalas, G., Reisenbauer, J., & Morandi, B. (2021). A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls. Chemical Communications. Royal Society of Chemistry. https://doi.org/10.1039/d1cc00648g"},"date_created":"2025-12-09T14:25:17Z","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","external_id":{"pmid":["33871510"]},"author":[{"first_name":"Suzanne","last_name":"Willems","full_name":"Willems, Suzanne"},{"first_name":"Georgios","last_name":"Toupalas","full_name":"Toupalas, Georgios"},{"id":"51d862e9-36ee-11f0-86d3-8534c85a5496","full_name":"Reisenbauer, Julia","first_name":"Julia","last_name":"Reisenbauer"},{"full_name":"Morandi, Bill","last_name":"Morandi","first_name":"Bill"}],"pmid":1,"OA_place":"publisher","scopus_import":"1","ddc":["540"],"type":"journal_article","publication":"Chemical Communications","date_updated":"2025-12-16T12:06:53Z","article_type":"original","article_processing_charge":"No","abstract":[{"text":"A cascade Suzuki–Miyaura cross-coupling between two non-symmetrical coupling partners gave rise to 9,10-dihydrophenanthrenes with full site-selectivity. The choice of base was critical to facilitate the challenging coupling of the secondary boronate group.
","lang":"eng"}],"language":[{"iso":"eng"}],"year":"2021","title":"A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls","volume":57,"extern":"1","oa":1,"day":"15","OA_type":"hybrid","publication_status":"published","doi":"10.1039/d1cc00648g","main_file_link":[{"url":"DOI\thttps://doi.org/10.1039/D1CC00648G","open_access":"1"}]},{"article_type":"original","article_processing_charge":"Yes","publication":"eLife","type":"journal_article","date_updated":"2025-07-10T11:51:41Z","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.7554/eLife.61769"}],"publication_status":"published","doi":"10.7554/elife.61769","year":"2021","volume":10,"title":"DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation","extern":"1","oa":1,"day":"19","OA_type":"gold","abstract":[{"lang":"eng","text":"The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus callosum (CC) and hippocampal commissure (HC). Deleted in colorectal carcinoma (DCC) and netrin 1 (NTN1) are molecules that have an evolutionarily conserved function in commissural axon guidance. The CC and HC are absent in Dcc and Ntn1 knockout mice, while other commissures are only partially affected, suggesting an additional aetiology in forebrain commissure formation. Here, we find that these molecules play a critical role in regulating astroglial development and IHF remodelling during CC and HC formation. Human subjects with DCC mutations display disrupted IHF remodelling associated with CC and HC malformations. Thus, axon guidance molecules such as DCC and NTN1 first regulate the formation of a midline substrate for dorsal commissures prior to their role in regulating axonal growth and guidance across it."}],"article_number":"61769","language":[{"iso":"eng"}],"citation":{"ista":"Morcom L, Gobius I, Marsh AP, Suárez R, Lim JW, Bridges C, Ye Y, Fenlon LR, Zagar Y, Douglass AM, Donahoo A-LS, Fothergill T, Shaikh S, Kozulin P, Edwards TJ, Cooper HM, Sherr EH, Chédotal A, Leventer RJ, Lockhart PJ, Richards LJ. 2021. DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. eLife. 10, 61769.","mla":"Morcom, Laura, et al. “DCC Regulates Astroglial Development Essential for Telencephalic Morphogenesis and Corpus Callosum Formation.” ELife, vol. 10, 61769, eLife Sciences Publications, 2021, doi:10.7554/elife.61769.","short":"L. Morcom, I. Gobius, A.P. Marsh, R. Suárez, J.W. Lim, C. Bridges, Y. Ye, L.R. Fenlon, Y. Zagar, A.M. Douglass, A.-L.S. Donahoo, T. Fothergill, S. Shaikh, P. Kozulin, T.J. Edwards, H.M. Cooper, E.H. Sherr, A. Chédotal, R.J. Leventer, P.J. Lockhart, L.J. Richards, ELife 10 (2021).","chicago":"Morcom, Laura, Ilan Gobius, Ashley PL Marsh, Rodrigo Suárez, Jonathan WC Lim, Caitlin Bridges, Yunan Ye, et al. “DCC Regulates Astroglial Development Essential for Telencephalic Morphogenesis and Corpus Callosum Formation.” ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/elife.61769.","apa":"Morcom, L., Gobius, I., Marsh, A. P., Suárez, R., Lim, J. W., Bridges, C., … Richards, L. J. (2021). DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.61769","ieee":"L. Morcom et al., “DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation,” eLife, vol. 10. eLife Sciences Publications, 2021.","ama":"Morcom L, Gobius I, Marsh AP, et al. DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. eLife. 2021;10. doi:10.7554/elife.61769"},"publisher":"eLife Sciences Publications","date_created":"2025-04-03T12:29:29Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"month":"04","status":"public","date_published":"2021-04-19T00:00:00Z","quality_controlled":"1","_id":"19472","intvolume":" 10","publication_identifier":{"eissn":["2050-084X"]},"external_id":{"pmid":["33871356"]},"DOAJ_listed":"1","pmid":1,"author":[{"full_name":"Morcom, Laura","first_name":"Laura","last_name":"Morcom"},{"first_name":"Ilan","last_name":"Gobius","full_name":"Gobius, Ilan"},{"first_name":"Ashley PL","last_name":"Marsh","full_name":"Marsh, Ashley PL"},{"full_name":"Suárez, Rodrigo","first_name":"Rodrigo","last_name":"Suárez"},{"full_name":"Lim, Jonathan WC","last_name":"Lim","first_name":"Jonathan WC"},{"last_name":"Bridges","first_name":"Caitlin","full_name":"Bridges, Caitlin"},{"first_name":"Yunan","last_name":"Ye","full_name":"Ye, Yunan"},{"full_name":"Fenlon, Laura R","last_name":"Fenlon","first_name":"Laura R"},{"full_name":"Zagar, Yvrick","first_name":"Yvrick","last_name":"Zagar"},{"full_name":"Douglass, Amelia May Barnett","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","orcid":"0000-0001-5398-6473","first_name":"Amelia May Barnett","last_name":"Douglass"},{"full_name":"Donahoo, Amber-Lee S","last_name":"Donahoo","first_name":"Amber-Lee S"},{"first_name":"Thomas","last_name":"Fothergill","full_name":"Fothergill, Thomas"},{"full_name":"Shaikh, Samreen","last_name":"Shaikh","first_name":"Samreen"},{"full_name":"Kozulin, Peter","first_name":"Peter","last_name":"Kozulin"},{"full_name":"Edwards, Timothy J","last_name":"Edwards","first_name":"Timothy J"},{"last_name":"Cooper","first_name":"Helen M","full_name":"Cooper, Helen M"},{"full_name":"Sherr, Elliott H","first_name":"Elliott H","last_name":"Sherr"},{"first_name":"Alain","last_name":"Chédotal","full_name":"Chédotal, Alain"},{"last_name":"Leventer","first_name":"Richard J","full_name":"Leventer, Richard J"},{"full_name":"Lockhart, Paul J","first_name":"Paul J","last_name":"Lockhart"},{"last_name":"Richards","first_name":"Linda J","full_name":"Richards, Linda J"}],"OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","has_accepted_license":"1"},{"has_accepted_license":"1","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Chan, Yik Tung","id":"c4c0afc8-9262-11ed-9231-d8b0bc743af1","orcid":"0000-0001-8467-4106","first_name":"Yik Tung","last_name":"Chan"},{"full_name":"McMeekin, Christine","first_name":"Christine","last_name":"McMeekin"},{"first_name":"Djordjo","last_name":"Milovic","full_name":"Milovic, Djordjo"}],"arxiv":1,"external_id":{"arxiv":["2005.10188"]},"OA_place":"publisher","intvolume":" 8","publication_identifier":{"issn":["2522-0160"],"eissn":["2363-9555"]},"_id":"19489","date_published":"2021-11-15T00:00:00Z","quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","month":"11","citation":{"chicago":"Chan, Stephanie, Christine McMeekin, and Djordjo Milovic. “A Density of Ramified Primes.” Research in Number Theory. Springer Nature, 2021. https://doi.org/10.1007/s40993-021-00295-5.","ista":"Chan S, McMeekin C, Milovic D. 2021. A density of ramified primes. Research in Number Theory. 8, 1.","short":"S. Chan, C. McMeekin, D. Milovic, Research in Number Theory 8 (2021).","mla":"Chan, Stephanie, et al. “A Density of Ramified Primes.” Research in Number Theory, vol. 8, 1, Springer Nature, 2021, doi:10.1007/s40993-021-00295-5.","apa":"Chan, S., McMeekin, C., & Milovic, D. (2021). A density of ramified primes. Research in Number Theory. Springer Nature. https://doi.org/10.1007/s40993-021-00295-5","ieee":"S. Chan, C. McMeekin, and D. Milovic, “A density of ramified primes,” Research in Number Theory, vol. 8. Springer Nature, 2021.","ama":"Chan S, McMeekin C, Milovic D. A density of ramified primes. Research in Number Theory. 2021;8. doi:10.1007/s40993-021-00295-5"},"publisher":"Springer Nature","date_created":"2025-04-05T10:50:51Z","abstract":[{"text":"Let K be a cyclic number field of odd degree over \r\n𝑄 with odd narrow class number, such that 2 is inert in 𝐾/𝑄. We define a family of number fields {𝐾(𝑝)}𝑝, depending on K and indexed by the rational primes p that split completely in 𝐾/𝑄, in which p is always ramified of degree 2. Conditional on a standard conjecture on short character sums, the density of such rational primes p that exhibit one of two possible ramified factorizations in 𝐾(𝑝)/𝑄 is strictly between 0 and 1 and is given explicitly as a formula in terms of the degree of the extension 𝐾/𝑄. Our results are unconditional in the cubic case. Our proof relies on a detailed study of the joint distribution of spins of prime ideals.","lang":"eng"}],"language":[{"iso":"eng"}],"article_number":"1","title":"A density of ramified primes","volume":8,"year":"2021","OA_type":"hybrid","day":"15","extern":"1","oa":1,"publication_status":"published","doi":"10.1007/s40993-021-00295-5","main_file_link":[{"url":"https://doi.org/10.1007/s40993-021-00295-5","open_access":"1"}],"ddc":["510"],"scopus_import":"1","date_updated":"2025-07-10T11:51:46Z","publication":"Research in Number Theory","type":"journal_article","article_type":"original","article_processing_charge":"No"},{"language":[{"iso":"eng"}],"abstract":[{"text":"Kuroda’s formula relates the class number of a multiquadratic number field K to the class numbers of its quadratic subfields ki. A key component in this formula is the unit group index (math formular). We study how Q(K) behaves on average in certain natural families of totally real biquadratic fields K parametrized by prime numbers.","lang":"eng"}],"oa":1,"extern":"1","OA_type":"green","day":"17","year":"2021","title":"Kuroda’s formula and arithmetic statistics","volume":300,"doi":"10.1007/s00209-021-02823-6","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1905.09745"}],"scopus_import":"1","publication":"Mathematische Zeitschrift","type":"journal_article","date_updated":"2025-07-10T11:51:48Z","article_processing_charge":"No","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","OA_place":"repository","external_id":{"arxiv":["1905.09745"]},"arxiv":1,"author":[{"id":"c4c0afc8-9262-11ed-9231-d8b0bc743af1","orcid":"0000-0001-8467-4106","full_name":"Chan, Yik Tung","first_name":"Yik Tung","last_name":"Chan"},{"first_name":"Djordjo","last_name":"Milovic","full_name":"Milovic, Djordjo"}],"_id":"19492","intvolume":" 300","publication_identifier":{"issn":["0025-5874"],"eissn":["1432-1823"]},"issue":"2","quality_controlled":"1","date_published":"2021-08-17T00:00:00Z","month":"08","status":"public","page":"1509-1527","date_created":"2025-04-05T10:51:04Z","publisher":"Springer Nature","citation":{"chicago":"Chan, Stephanie, and Djordjo Milovic. “Kuroda’s Formula and Arithmetic Statistics.” Mathematische Zeitschrift. Springer Nature, 2021. https://doi.org/10.1007/s00209-021-02823-6.","ista":"Chan S, Milovic D. 2021. Kuroda’s formula and arithmetic statistics. Mathematische Zeitschrift. 300(2), 1509–1527.","short":"S. Chan, D. Milovic, Mathematische Zeitschrift 300 (2021) 1509–1527.","mla":"Chan, Stephanie, and Djordjo Milovic. “Kuroda’s Formula and Arithmetic Statistics.” Mathematische Zeitschrift, vol. 300, no. 2, Springer Nature, 2021, pp. 1509–27, doi:10.1007/s00209-021-02823-6.","ieee":"S. Chan and D. Milovic, “Kuroda’s formula and arithmetic statistics,” Mathematische Zeitschrift, vol. 300, no. 2. Springer Nature, pp. 1509–1527, 2021.","apa":"Chan, S., & Milovic, D. (2021). Kuroda’s formula and arithmetic statistics. Mathematische Zeitschrift. Springer Nature. https://doi.org/10.1007/s00209-021-02823-6","ama":"Chan S, Milovic D. Kuroda’s formula and arithmetic statistics. Mathematische Zeitschrift. 2021;300(2):1509-1527. doi:10.1007/s00209-021-02823-6"}},{"day":"13","oa":1,"title":"Recent progress on two-dimensional materials","volume":37,"year":"2021","article_number":"2108017","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Research on two-dimensional (2D) materials has been explosively increasing in last seventeen years in varying subjects including condensed matter physics, electronic engineering, materials science, and chemistry since the mechanical exfoliation of graphene in 2004. Starting from graphene, 2D materials now have become a big family with numerous members and diverse categories. The unique structural features and physicochemical properties of 2D materials make them one class of the most appealing candidates for a wide range of potential applications. In particular, we have seen some major breakthroughs made in the field of 2D materials in last five years not only in developing novel synthetic methods and exploring new structures/properties but also in identifying innovative applications and pushing forward commercialisation. In this review, we provide a critical summary on the recent progress made in the field of 2D materials with a particular focus on last five years. After a brief background introduction, we first discuss the major synthetic methods for 2D materials, including the mechanical exfoliation, liquid exfoliation, vapor phase deposition, and wet-chemical synthesis as well as phase engineering of 2D materials belonging to the field of phase engineering of nanomaterials (PEN). We then introduce the superconducting/optical/magnetic properties and chirality of 2D materials along with newly emerging magic angle 2D superlattices. Following that, the promising applications of 2D materials in electronics, optoelectronics, catalysis, energy storage, solar cells, biomedicine, sensors, environments, etc. are described sequentially. Thereafter, we present the theoretic calculations and simulations of 2D materials. Finally, after concluding the current progress, we provide some personal discussions on the existing challenges and future outlooks in this rapidly developing field. "}],"main_file_link":[{"url":"https://doi.org/10.3866/PKU.WHXB202108017","open_access":"1"}],"doi":"10.3866/PKU.WHXB202108017","publication_status":"published","date_updated":"2025-09-10T10:12:25Z","publication":"Acta Physico-Chimica Sinica","type":"journal_article","scopus_import":"1","article_processing_charge":"No","article_type":"review","isi":1,"author":[{"first_name":"Cheng","last_name":"Chang","full_name":"Chang, Cheng","orcid":"0000-0002-9515-4277","id":"9E331C2E-9F27-11E9-AE48-5033E6697425"},{"first_name":"Wei","last_name":"Chen","full_name":"Chen, Wei"},{"first_name":"Ye","last_name":"Chen","full_name":"Chen, Ye"},{"full_name":"Chen, Yonghua","last_name":"Chen","first_name":"Yonghua"},{"full_name":"Chen, Yu","first_name":"Yu","last_name":"Chen"},{"last_name":"Ding","first_name":"Feng","full_name":"Ding, Feng"},{"full_name":"Fan, Chunhai","first_name":"Chunhai","last_name":"Fan"},{"first_name":"Hong Jin","last_name":"Fan","full_name":"Fan, Hong Jin"},{"last_name":"Fan","first_name":"Zhanxi","full_name":"Fan, Zhanxi"},{"first_name":"Cheng","last_name":"Gong","full_name":"Gong, Cheng"},{"full_name":"Gong, Yongji","first_name":"Yongji","last_name":"Gong"},{"full_name":"He, Qiyuan","first_name":"Qiyuan","last_name":"He"},{"last_name":"Hong","first_name":"Xun","full_name":"Hong, Xun"},{"last_name":"Hu","first_name":"Sheng","full_name":"Hu, Sheng"},{"full_name":"Hu, Weida","first_name":"Weida","last_name":"Hu"},{"full_name":"Huang, Wei","last_name":"Huang","first_name":"Wei"},{"full_name":"Huang, Yuan","last_name":"Huang","first_name":"Yuan"},{"last_name":"Ji","first_name":"Wei","full_name":"Ji, Wei"},{"full_name":"Li, Dehui","last_name":"Li","first_name":"Dehui"},{"first_name":"Lain Jong","last_name":"Li","full_name":"Li, Lain Jong"},{"full_name":"Li, Qiang","first_name":"Qiang","last_name":"Li"},{"full_name":"Lin, Li","last_name":"Lin","first_name":"Li"},{"first_name":"Chongyi","last_name":"Ling","full_name":"Ling, Chongyi"},{"full_name":"Liu, Minghua","last_name":"Liu","first_name":"Minghua"},{"first_name":"Nan","last_name":"Liu","full_name":"Liu, Nan"},{"last_name":"Liu","first_name":"Zhuang","full_name":"Liu, Zhuang"},{"full_name":"Loh, Kian Ping","last_name":"Loh","first_name":"Kian Ping"},{"first_name":"Jianmin","last_name":"Ma","full_name":"Ma, Jianmin"},{"full_name":"Miao, Feng","last_name":"Miao","first_name":"Feng"},{"last_name":"Peng","first_name":"Hailin","full_name":"Peng, Hailin"},{"full_name":"Shao, Mingfei","last_name":"Shao","first_name":"Mingfei"},{"first_name":"Li","last_name":"Song","full_name":"Song, Li"},{"full_name":"Su, Shao","last_name":"Su","first_name":"Shao"},{"first_name":"Shuo","last_name":"Sun","full_name":"Sun, Shuo"},{"first_name":"Chaoliang","last_name":"Tan","full_name":"Tan, Chaoliang"},{"first_name":"Zhiyong","last_name":"Tang","full_name":"Tang, Zhiyong"},{"first_name":"Dingsheng","last_name":"Wang","full_name":"Wang, Dingsheng"},{"first_name":"Huan","last_name":"Wang","full_name":"Wang, Huan"},{"first_name":"Jinlan","last_name":"Wang","full_name":"Wang, Jinlan"},{"full_name":"Wang, Xin","first_name":"Xin","last_name":"Wang"},{"last_name":"Wang","first_name":"Xinran","full_name":"Wang, Xinran"},{"first_name":"Andrew T.S.","last_name":"Wee","full_name":"Wee, Andrew T.S."},{"full_name":"Wei, Zhongming","first_name":"Zhongming","last_name":"Wei"},{"full_name":"Wu, Yuen","first_name":"Yuen","last_name":"Wu"},{"full_name":"Wu, Zhong Shuai","last_name":"Wu","first_name":"Zhong Shuai"},{"first_name":"Jie","last_name":"Xiong","full_name":"Xiong, Jie"},{"first_name":"Qihua","last_name":"Xiong","full_name":"Xiong, Qihua"},{"last_name":"Xu","first_name":"Weigao","full_name":"Xu, Weigao"},{"last_name":"Yin","first_name":"Peng","full_name":"Yin, Peng"},{"first_name":"Haibo","last_name":"Zeng","full_name":"Zeng, Haibo"},{"full_name":"Zeng, Zhiyuan","first_name":"Zhiyuan","last_name":"Zeng"},{"full_name":"Zhai, Tianyou","first_name":"Tianyou","last_name":"Zhai"},{"full_name":"Zhang, Han","first_name":"Han","last_name":"Zhang"},{"last_name":"Zhang","first_name":"Hui","full_name":"Zhang, Hui"},{"first_name":"Qichun","last_name":"Zhang","full_name":"Zhang, Qichun"},{"first_name":"Tierui","last_name":"Zhang","full_name":"Zhang, Tierui"},{"full_name":"Zhang, Xiang","first_name":"Xiang","last_name":"Zhang"},{"last_name":"Zhao","first_name":"Li Dong","full_name":"Zhao, Li Dong"},{"full_name":"Zhao, Meiting","last_name":"Zhao","first_name":"Meiting"},{"first_name":"Weijie","last_name":"Zhao","full_name":"Zhao, Weijie"},{"full_name":"Zhao, Yunxuan","last_name":"Zhao","first_name":"Yunxuan"},{"full_name":"Zhou, Kai Ge","last_name":"Zhou","first_name":"Kai Ge"},{"first_name":"Xing","last_name":"Zhou","full_name":"Zhou, Xing"},{"full_name":"Zhou, Yu","first_name":"Yu","last_name":"Zhou"},{"first_name":"Hongwei","last_name":"Zhu","full_name":"Zhu, Hongwei"},{"full_name":"Zhang, Hua","first_name":"Hua","last_name":"Zhang"},{"full_name":"Liu, Zhongfan","last_name":"Liu","first_name":"Zhongfan"}],"external_id":{"isi":["000731879300002"]},"oa_version":"Submitted Version","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","quality_controlled":"1","date_published":"2021-10-13T00:00:00Z","issue":"12","publication_identifier":{"issn":["1001-4861"]},"intvolume":" 37","_id":"14800","department":[{"_id":"MaIb"}],"date_created":"2024-01-14T23:00:58Z","publisher":"Peking University","citation":{"ieee":"C. Chang et al., “Recent progress on two-dimensional materials,” Acta Physico-Chimica Sinica, vol. 37, no. 12. Peking University, 2021.","ama":"Chang C, Chen W, Chen Y, et al. Recent progress on two-dimensional materials. Acta Physico-Chimica Sinica. 2021;37(12). doi:10.3866/PKU.WHXB202108017","apa":"Chang, C., Chen, W., Chen, Y., Chen, Y., Chen, Y., Ding, F., … Liu, Z. (2021). Recent progress on two-dimensional materials. Acta Physico-Chimica Sinica. Peking University. https://doi.org/10.3866/PKU.WHXB202108017","chicago":"Chang, Cheng, Wei Chen, Ye Chen, Yonghua Chen, Yu Chen, Feng Ding, Chunhai Fan, et al. “Recent Progress on Two-Dimensional Materials.” Acta Physico-Chimica Sinica. Peking University, 2021. https://doi.org/10.3866/PKU.WHXB202108017.","ista":"Chang C, Chen W, Chen Y, Chen Y, Chen Y, Ding F, Fan C, Fan HJ, Fan Z, Gong C, Gong Y, He Q, Hong X, Hu S, Hu W, Huang W, Huang Y, Ji W, Li D, Li LJ, Li Q, Lin L, Ling C, Liu M, Liu N, Liu Z, Loh KP, Ma J, Miao F, Peng H, Shao M, Song L, Su S, Sun S, Tan C, Tang Z, Wang D, Wang H, Wang J, Wang X, Wang X, Wee ATS, Wei Z, Wu Y, Wu ZS, Xiong J, Xiong Q, Xu W, Yin P, Zeng H, Zeng Z, Zhai T, Zhang H, Zhang H, Zhang Q, Zhang T, Zhang X, Zhao LD, Zhao M, Zhao W, Zhao Y, Zhou KG, Zhou X, Zhou Y, Zhu H, Zhang H, Liu Z. 2021. Recent progress on two-dimensional materials. Acta Physico-Chimica Sinica. 37(12), 2108017.","short":"C. Chang, W. Chen, Y. Chen, Y. Chen, Y. Chen, F. Ding, C. Fan, H.J. Fan, Z. Fan, C. Gong, Y. Gong, Q. He, X. Hong, S. Hu, W. Hu, W. Huang, Y. Huang, W. Ji, D. Li, L.J. Li, Q. Li, L. Lin, C. Ling, M. Liu, N. Liu, Z. Liu, K.P. Loh, J. Ma, F. Miao, H. Peng, M. Shao, L. Song, S. Su, S. Sun, C. Tan, Z. Tang, D. Wang, H. Wang, J. Wang, X. Wang, X. Wang, A.T.S. Wee, Z. Wei, Y. Wu, Z.S. Wu, J. Xiong, Q. Xiong, W. Xu, P. Yin, H. Zeng, Z. Zeng, T. Zhai, H. Zhang, H. Zhang, Q. Zhang, T. Zhang, X. Zhang, L.D. Zhao, M. Zhao, W. Zhao, Y. Zhao, K.G. Zhou, X. Zhou, Y. Zhou, H. Zhu, H. Zhang, Z. Liu, Acta Physico-Chimica Sinica 37 (2021).","mla":"Chang, Cheng, et al. “Recent Progress on Two-Dimensional Materials.” Acta Physico-Chimica Sinica, vol. 37, no. 12, 2108017, Peking University, 2021, doi:10.3866/PKU.WHXB202108017."},"status":"public","month":"10"},{"author":[{"full_name":"Leopold, Nikolai K","id":"4BC40BEC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0495-6822","last_name":"Leopold","first_name":"Nikolai K"},{"last_name":"Mitrouskas","first_name":"David Johannes","id":"cbddacee-2b11-11eb-a02e-a2e14d04e52d","full_name":"Mitrouskas, David Johannes"},{"id":"856966FE-A408-11E9-977E-802DE6697425","orcid":"0000-0001-5059-4466","full_name":"Rademacher, Simone Anna Elvira","last_name":"Rademacher","first_name":"Simone Anna Elvira"},{"first_name":"Benjamin","last_name":"Schlein","full_name":"Schlein, Benjamin"},{"id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","first_name":"Robert","last_name":"Seiringer"}],"external_id":{"arxiv":["2005.02098"]},"arxiv":1,"oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"Financial support by the European Union’s Horizon 2020 research and innovation programme\r\nunder the Marie Skłodowska-Curie grant agreement No. 754411 (S.R.) and the European\r\nResearch Council under grant agreement No. 694227 (N.L. and R.S.), as well as by the SNSF\r\nEccellenza project PCEFP2 181153 (N.L.), the NCCR SwissMAP (N.L. and B.S.) and by the\r\nDeutsche Forschungsgemeinschaft (DFG) through the Research Training Group 1838: Spectral\r\nTheory and Dynamics of Quantum Systems (D.M.) is gratefully acknowledged. B.S. gratefully\r\nacknowledges financial support from the Swiss National Science Foundation through the Grant\r\n“Dynamical and energetic properties of Bose-Einstein condensates” and from the European\r\nResearch Council through the ERC-AdG CLaQS (grant agreement No 834782). D.M. thanks\r\nMarcel Griesemer for helpful discussions.","publisher":"Mathematical Sciences Publishers","citation":{"short":"N.K. Leopold, D.J. Mitrouskas, S.A.E. Rademacher, B. Schlein, R. Seiringer, Pure and Applied Analysis 3 (2021) 653–676.","mla":"Leopold, Nikolai K., et al. “Landau–Pekar Equations and Quantum Fluctuations for the Dynamics of a Strongly Coupled Polaron.” Pure and Applied Analysis, vol. 3, no. 4, Mathematical Sciences Publishers, 2021, pp. 653–76, doi:10.2140/paa.2021.3.653.","ista":"Leopold NK, Mitrouskas DJ, Rademacher SAE, Schlein B, Seiringer R. 2021. Landau–Pekar equations and quantum fluctuations for the dynamics of a strongly coupled polaron. Pure and Applied Analysis. 3(4), 653–676.","chicago":"Leopold, Nikolai K, David Johannes Mitrouskas, Simone Anna Elvira Rademacher, Benjamin Schlein, and Robert Seiringer. “Landau–Pekar Equations and Quantum Fluctuations for the Dynamics of a Strongly Coupled Polaron.” Pure and Applied Analysis. Mathematical Sciences Publishers, 2021. https://doi.org/10.2140/paa.2021.3.653.","ieee":"N. K. Leopold, D. J. Mitrouskas, S. A. E. Rademacher, B. Schlein, and R. Seiringer, “Landau–Pekar equations and quantum fluctuations for the dynamics of a strongly coupled polaron,” Pure and Applied Analysis, vol. 3, no. 4. Mathematical Sciences Publishers, pp. 653–676, 2021.","ama":"Leopold NK, Mitrouskas DJ, Rademacher SAE, Schlein B, Seiringer R. Landau–Pekar equations and quantum fluctuations for the dynamics of a strongly coupled polaron. Pure and Applied Analysis. 2021;3(4):653-676. doi:10.2140/paa.2021.3.653","apa":"Leopold, N. K., Mitrouskas, D. J., Rademacher, S. A. E., Schlein, B., & Seiringer, R. (2021). Landau–Pekar equations and quantum fluctuations for the dynamics of a strongly coupled polaron. Pure and Applied Analysis. Mathematical Sciences Publishers. https://doi.org/10.2140/paa.2021.3.653"},"department":[{"_id":"RoSe"}],"date_created":"2024-01-28T23:01:43Z","page":"653-676","status":"public","month":"10","date_published":"2021-10-01T00:00:00Z","project":[{"name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411"},{"grant_number":"694227","call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems"}],"quality_controlled":"1","publication_identifier":{"eissn":["2578-5885"],"issn":["2578-5893"]},"intvolume":" 3","issue":"4","_id":"14889","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2005.02098","open_access":"1"}],"ec_funded":1,"publication_status":"published","doi":"10.2140/paa.2021.3.653","volume":3,"title":"Landau–Pekar equations and quantum fluctuations for the dynamics of a strongly coupled polaron","year":"2021","day":"01","oa":1,"abstract":[{"text":"We consider the Fröhlich Hamiltonian with large coupling constant α. For initial data of Pekar product form with coherent phonon field and with the electron minimizing the corresponding energy, we provide a norm approximation of the evolution, valid up to times of order α2. The approximation is given in terms of a Pekar product state, evolved through the Landau-Pekar equations, corrected by a Bogoliubov dynamics taking quantum fluctuations into account. This allows us to show that the Landau-Pekar equations approximately describe the evolution of the electron- and one-phonon reduced density matrices under the Fröhlich dynamics up to times of order α2.","lang":"eng"}],"corr_author":"1","language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"No","date_updated":"2025-04-14T07:27:00Z","publication":"Pure and Applied Analysis","type":"journal_article","scopus_import":"1"},{"article_processing_charge":"No","article_type":"original","type":"journal_article","publication":"Pure and Applied Analysis","date_updated":"2025-04-14T07:44:02Z","scopus_import":"1","ec_funded":1,"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1912.11004","open_access":"1"}],"doi":"10.2140/paa.2021.3.677","publication_status":"published","oa":1,"day":"01","year":"2021","title":"Beyond Bogoliubov dynamics","volume":3,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We consider a system of N interacting bosons in the mean-field scaling regime and construct corrections to the Bogoliubov dynamics that approximate the true N-body dynamics in norm to arbitrary precision. The N-independent corrections are given in terms of the solutions of the Bogoliubov and Hartree equations and satisfy a generalized form of Wick's theorem. We determine the n-point correlation functions of the excitations around the condensate, as well as the reduced densities of the N-body system, to arbitrary accuracy, given only the knowledge of the two-point functions of a quasi-free state and the solution of the Hartree equation. In this way, the complex problem of computing all n-point correlation functions for an interacting N-body system is essentially reduced to the problem of solving the Hartree equation and the PDEs for the Bogoliubov two-point functions."}],"corr_author":"1","department":[{"_id":"RoSe"}],"date_created":"2024-01-28T23:01:43Z","citation":{"ista":"Bossmann L, Petrat SP, Pickl P, Soffer A. 2021. Beyond Bogoliubov dynamics. Pure and Applied Analysis. 3(4), 677–726.","mla":"Bossmann, Lea, et al. “Beyond Bogoliubov Dynamics.” Pure and Applied Analysis, vol. 3, no. 4, Mathematical Sciences Publishers, 2021, pp. 677–726, doi:10.2140/paa.2021.3.677.","short":"L. Bossmann, S.P. Petrat, P. Pickl, A. Soffer, Pure and Applied Analysis 3 (2021) 677–726.","chicago":"Bossmann, Lea, Sören P Petrat, Peter Pickl, and Avy Soffer. “Beyond Bogoliubov Dynamics.” Pure and Applied Analysis. Mathematical Sciences Publishers, 2021. https://doi.org/10.2140/paa.2021.3.677.","ieee":"L. Bossmann, S. P. Petrat, P. Pickl, and A. Soffer, “Beyond Bogoliubov dynamics,” Pure and Applied Analysis, vol. 3, no. 4. Mathematical Sciences Publishers, pp. 677–726, 2021.","apa":"Bossmann, L., Petrat, S. P., Pickl, P., & Soffer, A. (2021). Beyond Bogoliubov dynamics. Pure and Applied Analysis. Mathematical Sciences Publishers. https://doi.org/10.2140/paa.2021.3.677","ama":"Bossmann L, Petrat SP, Pickl P, Soffer A. Beyond Bogoliubov dynamics. Pure and Applied Analysis. 2021;3(4):677-726. doi:10.2140/paa.2021.3.677"},"publisher":"Mathematical Sciences Publishers","month":"10","status":"public","page":"677-726","quality_controlled":"1","project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"date_published":"2021-10-01T00:00:00Z","_id":"14890","publication_identifier":{"issn":["2578-5893"],"eissn":["2578-5885"]},"issue":"4","intvolume":" 3","arxiv":1,"external_id":{"arxiv":["1912.11004"]},"author":[{"first_name":"Lea","last_name":"Bossmann","id":"A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425","full_name":"Bossmann, Lea","orcid":"0000-0002-6854-1343"},{"id":"40AC02DC-F248-11E8-B48F-1D18A9856A87","full_name":"Petrat, Sören P","orcid":"0000-0002-9166-5889","first_name":"Sören P","last_name":"Petrat"},{"last_name":"Pickl","first_name":"Peter","full_name":"Pickl, Peter"},{"full_name":"Soffer, Avy","first_name":"Avy","last_name":"Soffer"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","acknowledgement":"We are grateful for the hospitality of Central China Normal University (CCNU),\r\nwhere parts of this work were done, and thank Phan Th`anh Nam, Simone\r\nRademacher, Robert Seiringer and Stefan Teufel for helpful discussions. L.B. gratefully acknowledges the support by the German Research Foundation (DFG) within the Research\r\nTraining Group 1838 “Spectral Theory and Dynamics of Quantum Systems”, and the funding\r\nfrom the European Union’s Horizon 2020 research and innovation programme under the Marie\r\nSk lodowska-Curie Grant Agreement No. 754411."},{"year":"2021","title":"Hybrid Zones","volume":2,"day":"28","corr_author":"1","abstract":[{"lang":"eng","text":"Hybrid zones are narrow geographic regions where different populations, races or interbreeding species meet and mate, producing mixed ‘hybrid’ offspring. They are relatively common and can be found in a diverse range of organisms and environments. The study of hybrid zones has played an important role in our understanding of the origin of species, with hybrid zones having been described as ‘natural laboratories’. This is because they allow us to study,in situ, the conditions and evolutionary forces that enable divergent taxa to remain distinct despite some ongoing gene exchange between them."}],"language":[{"iso":"eng"}],"author":[{"full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","first_name":"Sean","last_name":"Stankowski"},{"full_name":"Shipilina, Daria","orcid":"0000-0002-1145-9226","id":"428A94B0-F248-11E8-B48F-1D18A9856A87","last_name":"Shipilina","first_name":"Daria"},{"full_name":"Westram, Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1050-4969","last_name":"Westram","first_name":"Anja M"}],"publication_status":"published","doi":"10.1002/9780470015902.a0029355","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"None","date_published":"2021-05-28T00:00:00Z","publication":"Encyclopedia of Life Sciences","type":"book_chapter","quality_controlled":"1","date_updated":"2024-10-09T21:08:11Z","_id":"14984","publication_identifier":{"isbn":["9780470016176"],"eisbn":["9780470015902"]},"intvolume":" 2","citation":{"ieee":"S. Stankowski, D. Shipilina, and A. M. Westram, “Hybrid Zones,” in Encyclopedia of Life Sciences, vol. 2, Wiley, 2021.","ama":"Stankowski S, Shipilina D, Westram AM. Hybrid Zones. In: Encyclopedia of Life Sciences. Vol 2. eLS. Wiley; 2021. doi:10.1002/9780470015902.a0029355","apa":"Stankowski, S., Shipilina, D., & Westram, A. M. (2021). Hybrid Zones. In Encyclopedia of Life Sciences (Vol. 2). Wiley. https://doi.org/10.1002/9780470015902.a0029355","mla":"Stankowski, Sean, et al. “Hybrid Zones.” Encyclopedia of Life Sciences, vol. 2, Wiley, 2021, doi:10.1002/9780470015902.a0029355.","short":"S. Stankowski, D. Shipilina, A.M. Westram, in:, Encyclopedia of Life Sciences, Wiley, 2021.","ista":"Stankowski S, Shipilina D, Westram AM. 2021.Hybrid Zones. In: Encyclopedia of Life Sciences. vol. 2.","chicago":"Stankowski, Sean, Daria Shipilina, and Anja M Westram. “Hybrid Zones.” In Encyclopedia of Life Sciences, Vol. 2. ELS. Wiley, 2021. https://doi.org/10.1002/9780470015902.a0029355."},"publisher":"Wiley","date_created":"2024-02-14T12:05:50Z","department":[{"_id":"NiBa"}],"series_title":"eLS","month":"05","article_processing_charge":"No","status":"public"},{"page":"1395-1397","status":"public","editor":[{"first_name":"Katsushi","last_name":"Ikeuchi","full_name":"Ikeuchi, Katsushi"}],"month":"10","article_processing_charge":"No","citation":{"ama":"Lampert C. Zero-Shot Learning. In: Ikeuchi K, ed. Computer Vision. 2nd ed. Cham: Springer; 2021:1395-1397. doi:10.1007/978-3-030-63416-2_874","ieee":"C. Lampert, “Zero-Shot Learning,” in Computer Vision, 2nd ed., K. Ikeuchi, Ed. Cham: Springer, 2021, pp. 1395–1397.","apa":"Lampert, C. (2021). Zero-Shot Learning. In K. Ikeuchi (Ed.), Computer Vision (2nd ed., pp. 1395–1397). Cham: Springer. https://doi.org/10.1007/978-3-030-63416-2_874","mla":"Lampert, Christoph. “Zero-Shot Learning.” Computer Vision, edited by Katsushi Ikeuchi, 2nd ed., Springer, 2021, pp. 1395–97, doi:10.1007/978-3-030-63416-2_874.","short":"C. Lampert, in:, K. Ikeuchi (Ed.), Computer Vision, 2nd ed., Springer, Cham, 2021, pp. 1395–1397.","ista":"Lampert C. 2021.Zero-Shot Learning. In: Computer Vision. , 1395–1397.","chicago":"Lampert, Christoph. “Zero-Shot Learning.” In Computer Vision, edited by Katsushi Ikeuchi, 2nd ed., 1395–97. Cham: Springer, 2021. https://doi.org/10.1007/978-3-030-63416-2_874."},"publisher":"Springer","department":[{"_id":"ChLa"}],"date_created":"2024-02-14T14:05:32Z","publication_identifier":{"eisbn":["9783030634162"],"isbn":["9783030634155"]},"_id":"14987","date_published":"2021-10-13T00:00:00Z","place":"Cham","quality_controlled":"1","date_updated":"2024-10-09T21:08:12Z","publication":"Computer Vision","type":"book_chapter","publication_status":"published","oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1007/978-3-030-63416-2_874","author":[{"last_name":"Lampert","first_name":"Christoph","orcid":"0000-0001-8622-7887","full_name":"Lampert, Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"lang":"eng","text":"The goal of zero-shot learning is to construct a classifier that can identify object classes for which no training examples are available. When training data for some of the object classes is available but not for others, the name generalized zero-shot learning is commonly used.\r\nIn a wider sense, the phrase zero-shot is also used to describe other machine learning-based approaches that require no training data from the problem of interest, such as zero-shot action recognition or zero-shot machine translation."}],"corr_author":"1","language":[{"iso":"eng"}],"edition":"2","title":"Zero-Shot Learning","year":"2021","day":"13"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.5281/ZENODO.5747100","oa_version":"Published Version","related_material":{"record":[{"status":"public","id":"9887","relation":"used_in_publication"}]},"author":[{"full_name":"Johnson, Alexander J","id":"46A62C3A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2739-8843","last_name":"Johnson","first_name":"Alexander J"}],"main_file_link":[{"url":"https://doi.org/10.5281/zenodo.5747100","open_access":"1"}],"abstract":[{"lang":"eng","text":"Raw data generated from the publication - The TPLATE complex mediates membrane bending during plant clathrin-mediated endocytosis by Johnson et al., 2021 In PNAS"}],"corr_author":"1","has_accepted_license":"1","oa":1,"day":"01","year":"2021","title":"Raw data from Johnson et al, PNAS, 2021","article_processing_charge":"No","month":"12","status":"public","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_created":"2024-02-14T14:13:48Z","department":[{"_id":"JiFr"}],"publisher":"Zenodo","citation":{"short":"A.J. Johnson, (2021).","mla":"Johnson, Alexander J. Raw Data from Johnson et Al, PNAS, 2021. Zenodo, 2021, doi:10.5281/ZENODO.5747100.","ista":"Johnson AJ. 2021. Raw data from Johnson et al, PNAS, 2021, Zenodo, 10.5281/ZENODO.5747100.","chicago":"Johnson, Alexander J. “Raw Data from Johnson et Al, PNAS, 2021.” Zenodo, 2021. https://doi.org/10.5281/ZENODO.5747100.","apa":"Johnson, A. J. (2021). Raw data from Johnson et al, PNAS, 2021. Zenodo. https://doi.org/10.5281/ZENODO.5747100","ama":"Johnson AJ. Raw data from Johnson et al, PNAS, 2021. 2021. doi:10.5281/ZENODO.5747100","ieee":"A. J. Johnson, “Raw data from Johnson et al, PNAS, 2021.” Zenodo, 2021."},"_id":"14988","ddc":["580"],"type":"research_data_reference","date_updated":"2025-05-14T09:25:33Z","date_published":"2021-12-01T00:00:00Z"},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1907.13631"}],"ec_funded":1,"publication_status":"published","doi":"10.2140/pmp.2021.2.221","volume":2,"title":"Spectral radius of random matrices with independent entries","year":"2021","day":"21","oa":1,"abstract":[{"lang":"eng","text":"We consider random n×n matrices X with independent and centered entries and a general variance profile. We show that the spectral radius of X converges with very high probability to the square root of the spectral radius of the variance matrix of X when n tends to infinity. We also establish the optimal rate of convergence, that is a new result even for general i.i.d. matrices beyond the explicitly solvable Gaussian cases. The main ingredient is the proof of the local inhomogeneous circular law [arXiv:1612.07776] at the spectral edge."}],"corr_author":"1","language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"No","date_updated":"2025-04-15T08:05:02Z","type":"journal_article","publication":"Probability and Mathematical Physics","scopus_import":"1","author":[{"first_name":"Johannes","last_name":"Alt","full_name":"Alt, Johannes","id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"László","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","orcid":"0000-0001-5366-9603"},{"first_name":"Torben H","last_name":"Krüger","full_name":"Krüger, Torben H","orcid":"0000-0002-4821-3297","id":"3020C786-F248-11E8-B48F-1D18A9856A87"}],"arxiv":1,"external_id":{"arxiv":["1907.13631"]},"oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"Partially supported by ERC Starting Grant RandMat No. 715539 and the SwissMap grant of Swiss National Science Foundation. Partially supported by ERC Advanced Grant RanMat No. 338804. Partially supported by the Hausdorff Center for Mathematics in Bonn.","citation":{"chicago":"Alt, Johannes, László Erdös, and Torben H Krüger. “Spectral Radius of Random Matrices with Independent Entries.” Probability and Mathematical Physics. Mathematical Sciences Publishers, 2021. https://doi.org/10.2140/pmp.2021.2.221.","ista":"Alt J, Erdös L, Krüger TH. 2021. Spectral radius of random matrices with independent entries. Probability and Mathematical Physics. 2(2), 221–280.","short":"J. Alt, L. Erdös, T.H. Krüger, Probability and Mathematical Physics 2 (2021) 221–280.","mla":"Alt, Johannes, et al. “Spectral Radius of Random Matrices with Independent Entries.” Probability and Mathematical Physics, vol. 2, no. 2, Mathematical Sciences Publishers, 2021, pp. 221–80, doi:10.2140/pmp.2021.2.221.","apa":"Alt, J., Erdös, L., & Krüger, T. H. (2021). Spectral radius of random matrices with independent entries. Probability and Mathematical Physics. Mathematical Sciences Publishers. https://doi.org/10.2140/pmp.2021.2.221","ieee":"J. Alt, L. Erdös, and T. H. Krüger, “Spectral radius of random matrices with independent entries,” Probability and Mathematical Physics, vol. 2, no. 2. Mathematical Sciences Publishers, pp. 221–280, 2021.","ama":"Alt J, Erdös L, Krüger TH. Spectral radius of random matrices with independent entries. Probability and Mathematical Physics. 2021;2(2):221-280. doi:10.2140/pmp.2021.2.221"},"publisher":"Mathematical Sciences Publishers","department":[{"_id":"LaEr"}],"date_created":"2024-02-18T23:01:03Z","page":"221-280","status":"public","month":"05","date_published":"2021-05-21T00:00:00Z","project":[{"grant_number":"338804","call_identifier":"FP7","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems"}],"quality_controlled":"1","issue":"2","intvolume":" 2","publication_identifier":{"issn":["2690-0998"],"eissn":["2690-1005"]},"_id":"15013"},{"date_published":"2021-08-19T00:00:00Z","quality_controlled":"1","publication_identifier":{"issn":["2041-1723"]},"intvolume":" 12","_id":"15137","citation":{"ieee":"J. A. Steens et al., “SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation,” Nature Communications, vol. 12. Springer Nature, 2021.","apa":"Steens, J. A., Zhu, Y., Taylor, D. W., Bravo, J. P. K., Prinsen, S. H. P., Schoen, C. D., … Staals, R. H. J. (2021). SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-021-25337-5","ama":"Steens JA, Zhu Y, Taylor DW, et al. SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation. Nature Communications. 2021;12. doi:10.1038/s41467-021-25337-5","ista":"Steens JA, Zhu Y, Taylor DW, Bravo JPK, Prinsen SHP, Schoen CD, Keijser BJF, Ossendrijver M, Hofstra LM, Brouns SJJ, Shinkai A, van der Oost J, Staals RHJ. 2021. SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation. Nature Communications. 12, 5033.","mla":"Steens, Jurre A., et al. “SCOPE Enables Type III CRISPR-Cas Diagnostics Using Flexible Targeting and Stringent CARF Ribonuclease Activation.” Nature Communications, vol. 12, 5033, Springer Nature, 2021, doi:10.1038/s41467-021-25337-5.","short":"J.A. Steens, Y. Zhu, D.W. Taylor, J.P.K. Bravo, S.H.P. Prinsen, C.D. Schoen, B.J.F. Keijser, M. Ossendrijver, L.M. Hofstra, S.J.J. Brouns, A. Shinkai, J. van der Oost, R.H.J. Staals, Nature Communications 12 (2021).","chicago":"Steens, Jurre A., Yifan Zhu, David W. Taylor, Jack Peter Kelly Bravo, Stijn H. P. Prinsen, Cor D. Schoen, Bart J. F. Keijser, et al. “SCOPE Enables Type III CRISPR-Cas Diagnostics Using Flexible Targeting and Stringent CARF Ribonuclease Activation.” Nature Communications. Springer Nature, 2021. https://doi.org/10.1038/s41467-021-25337-5."},"publisher":"Springer Nature","date_created":"2024-03-20T10:42:33Z","status":"public","month":"08","keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"pmid":1,"author":[{"last_name":"Steens","first_name":"Jurre A.","full_name":"Steens, Jurre A."},{"first_name":"Yifan","last_name":"Zhu","full_name":"Zhu, Yifan"},{"last_name":"Taylor","first_name":"David W.","full_name":"Taylor, David W."},{"id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","orcid":"0000-0003-0456-0753","full_name":"Bravo, Jack Peter Kelly","first_name":"Jack Peter Kelly","last_name":"Bravo"},{"full_name":"Prinsen, Stijn H. P.","last_name":"Prinsen","first_name":"Stijn H. P."},{"last_name":"Schoen","first_name":"Cor D.","full_name":"Schoen, Cor D."},{"full_name":"Keijser, Bart J. F.","last_name":"Keijser","first_name":"Bart J. F."},{"first_name":"Michel","last_name":"Ossendrijver","full_name":"Ossendrijver, Michel"},{"first_name":"L. Marije","last_name":"Hofstra","full_name":"Hofstra, L. Marije"},{"first_name":"Stan J. J.","last_name":"Brouns","full_name":"Brouns, Stan J. J."},{"first_name":"Akeo","last_name":"Shinkai","full_name":"Shinkai, Akeo"},{"first_name":"John","last_name":"van der Oost","full_name":"van der Oost, John"},{"full_name":"Staals, Raymond H. J.","first_name":"Raymond H. J.","last_name":"Staals"}],"external_id":{"pmid":["34413302"]},"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-06-04T06:11:54Z","publication":"Nature Communications","type":"journal_article","scopus_import":"1","article_type":"original","article_processing_charge":"Yes","title":"SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation","volume":12,"year":"2021","day":"19","extern":"1","oa":1,"abstract":[{"lang":"eng","text":"Characteristic properties of type III CRISPR-Cas systems include recognition of target RNA and the subsequent induction of a multifaceted immune response. This involves sequence-specific cleavage of the target RNA and production of cyclic oligoadenylate (cOA) molecules. Here we report that an exposed seed region at the 3′ end of the crRNA is essential for target RNA binding and cleavage, whereas cOA production requires base pairing at the 5′ end of the crRNA. Moreover, we uncover that the variation in the size and composition of type III complexes within a single host results in variable seed regions. This may prevent escape by invading genetic elements, while controlling cOA production tightly to prevent unnecessary damage to the host. Lastly, we use these findings to develop a new diagnostic tool, SCOPE, for the specific detection of SARS-CoV-2 from human nasal swab samples, revealing sensitivities in the atto-molar range."}],"language":[{"iso":"eng"}],"article_number":"5033","main_file_link":[{"url":"https://doi.org/10.1038/s41467-021-25337-5","open_access":"1"}],"publication_status":"published","doi":"10.1038/s41467-021-25337-5"},{"status":"public","month":"11","date_created":"2024-03-20T10:42:39Z","citation":{"chicago":"Geiger, Florian, Julia Acker, Guido Papa, Xinyu Wang, William E Arter, Kadi L Saar, Nadia A Erkamp, et al. “Liquid–Liquid Phase Separation Underpins the Formation of Replication Factories in Rotaviruses.” The EMBO Journal. Embo Press, 2021. https://doi.org/10.15252/embj.2021107711.","short":"F. Geiger, J. Acker, G. Papa, X. Wang, W.E. Arter, K.L. Saar, N.A. Erkamp, R. Qi, J.P.K. Bravo, S. Strauss, G. Krainer, O.R. Burrone, R. Jungmann, T.P. Knowles, H. Engelke, A. Borodavka, The EMBO Journal 40 (2021).","mla":"Geiger, Florian, et al. “Liquid–Liquid Phase Separation Underpins the Formation of Replication Factories in Rotaviruses.” The EMBO Journal, vol. 40, no. 21, e107711, Embo Press, 2021, doi:10.15252/embj.2021107711.","ista":"Geiger F, Acker J, Papa G, Wang X, Arter WE, Saar KL, Erkamp NA, Qi R, Bravo JPK, Strauss S, Krainer G, Burrone OR, Jungmann R, Knowles TP, Engelke H, Borodavka A. 2021. Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses. The EMBO Journal. 40(21), e107711.","ama":"Geiger F, Acker J, Papa G, et al. Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses. The EMBO Journal. 2021;40(21). doi:10.15252/embj.2021107711","apa":"Geiger, F., Acker, J., Papa, G., Wang, X., Arter, W. E., Saar, K. L., … Borodavka, A. (2021). Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses. The EMBO Journal. Embo Press. https://doi.org/10.15252/embj.2021107711","ieee":"F. Geiger et al., “Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses,” The EMBO Journal, vol. 40, no. 21. Embo Press, 2021."},"publisher":"Embo Press","intvolume":" 40","publication_identifier":{"eissn":["1460-2075"],"issn":["0261-4189"]},"issue":"21","_id":"15138","quality_controlled":"1","date_published":"2021-11-02T00:00:00Z","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Geiger, Florian","first_name":"Florian","last_name":"Geiger"},{"first_name":"Julia","last_name":"Acker","full_name":"Acker, Julia"},{"last_name":"Papa","first_name":"Guido","full_name":"Papa, Guido"},{"full_name":"Wang, Xinyu","last_name":"Wang","first_name":"Xinyu"},{"full_name":"Arter, William E","last_name":"Arter","first_name":"William E"},{"first_name":"Kadi L","last_name":"Saar","full_name":"Saar, Kadi L"},{"full_name":"Erkamp, Nadia A","first_name":"Nadia A","last_name":"Erkamp"},{"first_name":"Runzhang","last_name":"Qi","full_name":"Qi, Runzhang"},{"orcid":"0000-0003-0456-0753","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","full_name":"Bravo, Jack Peter Kelly","first_name":"Jack Peter Kelly","last_name":"Bravo"},{"first_name":"Sebastian","last_name":"Strauss","full_name":"Strauss, Sebastian"},{"full_name":"Krainer, Georg","last_name":"Krainer","first_name":"Georg"},{"last_name":"Burrone","first_name":"Oscar R","full_name":"Burrone, Oscar R"},{"full_name":"Jungmann, Ralf","first_name":"Ralf","last_name":"Jungmann"},{"full_name":"Knowles, Tuomas PJ","last_name":"Knowles","first_name":"Tuomas PJ"},{"full_name":"Engelke, Hanna","first_name":"Hanna","last_name":"Engelke"},{"last_name":"Borodavka","first_name":"Alexander","full_name":"Borodavka, Alexander"}],"pmid":1,"external_id":{"pmid":["34524703"]},"keyword":["General Immunology and Microbiology","General Biochemistry","Genetics and Molecular Biology","Molecular Biology","General Neuroscience"],"article_processing_charge":"Yes","article_type":"original","scopus_import":"1","date_updated":"2024-06-04T06:08:16Z","type":"journal_article","publication":"The EMBO Journal","doi":"10.15252/embj.2021107711","publication_status":"published","main_file_link":[{"url":"https://doi.org/10.15252/embj.2021107711","open_access":"1"}],"language":[{"iso":"eng"}],"article_number":"e107711","abstract":[{"text":"RNA viruses induce the formation of subcellular organelles that provide microenvironments conducive to their replication. Here we show that replication factories of rotaviruses represent protein‐RNA condensates that are formed via liquid–liquid phase separation of the viroplasm‐forming proteins NSP5 and rotavirus RNA chaperone NSP2. Upon mixing, these proteins readily form condensates at physiologically relevant low micromolar concentrations achieved in the cytoplasm of virus‐infected cells. Early infection stage condensates could be reversibly dissolved by 1,6‐hexanediol, as well as propylene glycol that released rotavirus transcripts from these condensates. During the early stages of infection, propylene glycol treatments reduced viral replication and phosphorylation of the condensate‐forming protein NSP5. During late infection, these condensates exhibited altered material properties and became resistant to propylene glycol, coinciding with hyperphosphorylation of NSP5. Some aspects of the assembly of cytoplasmic rotavirus replication factories mirror the formation of other ribonucleoprotein granules. Such viral RNA‐rich condensates that support replication of multi‐segmented genomes represent an attractive target for developing novel therapeutic approaches.","lang":"eng"}],"day":"02","extern":"1","oa":1,"volume":40,"title":"Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses","year":"2021"},{"_id":"15139","issue":"41","intvolume":" 118","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"date_published":"2021-10-06T00:00:00Z","quality_controlled":"1","month":"10","status":"public","publisher":"Proceedings of the National Academy of Sciences","citation":{"ieee":"J. P. K. Bravo et al., “Structural basis of rotavirus RNA chaperone displacement and RNA annealing,” Proceedings of the National Academy of Sciences, vol. 118, no. 41. Proceedings of the National Academy of Sciences, 2021.","apa":"Bravo, J. P. K., Bartnik, K., Venditti, L., Acker, J., Gail, E. H., Colyer, A., … Borodavka, A. (2021). Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2100198118","ama":"Bravo JPK, Bartnik K, Venditti L, et al. Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Proceedings of the National Academy of Sciences. 2021;118(41). doi:10.1073/pnas.2100198118","ista":"Bravo JPK, Bartnik K, Venditti L, Acker J, Gail EH, Colyer A, Davidovich C, Lamb DC, Tuma R, Calabrese AN, Borodavka A. 2021. Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Proceedings of the National Academy of Sciences. 118(41), e2100198118.","mla":"Bravo, Jack Peter Kelly, et al. “Structural Basis of Rotavirus RNA Chaperone Displacement and RNA Annealing.” Proceedings of the National Academy of Sciences, vol. 118, no. 41, e2100198118, Proceedings of the National Academy of Sciences, 2021, doi:10.1073/pnas.2100198118.","short":"J.P.K. Bravo, K. Bartnik, L. Venditti, J. Acker, E.H. Gail, A. Colyer, C. Davidovich, D.C. Lamb, R. Tuma, A.N. Calabrese, A. Borodavka, Proceedings of the National Academy of Sciences 118 (2021).","chicago":"Bravo, Jack Peter Kelly, Kira Bartnik, Luca Venditti, Julia Acker, Emma H. Gail, Alice Colyer, Chen Davidovich, et al. “Structural Basis of Rotavirus RNA Chaperone Displacement and RNA Annealing.” Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences, 2021. https://doi.org/10.1073/pnas.2100198118."},"date_created":"2024-03-20T10:42:45Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","external_id":{"pmid":["34615715"]},"author":[{"id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","orcid":"0000-0003-0456-0753","full_name":"Bravo, Jack Peter Kelly","first_name":"Jack Peter Kelly","last_name":"Bravo"},{"last_name":"Bartnik","first_name":"Kira","full_name":"Bartnik, Kira"},{"full_name":"Venditti, Luca","first_name":"Luca","last_name":"Venditti"},{"full_name":"Acker, Julia","last_name":"Acker","first_name":"Julia"},{"full_name":"Gail, Emma H.","first_name":"Emma H.","last_name":"Gail"},{"full_name":"Colyer, Alice","last_name":"Colyer","first_name":"Alice"},{"full_name":"Davidovich, Chen","first_name":"Chen","last_name":"Davidovich"},{"full_name":"Lamb, Don C.","first_name":"Don C.","last_name":"Lamb"},{"full_name":"Tuma, Roman","last_name":"Tuma","first_name":"Roman"},{"last_name":"Calabrese","first_name":"Antonio N.","full_name":"Calabrese, Antonio N."},{"last_name":"Borodavka","first_name":"Alexander","full_name":"Borodavka, Alexander"}],"pmid":1,"scopus_import":"1","type":"journal_article","publication":"Proceedings of the National Academy of Sciences","date_updated":"2024-06-04T06:04:07Z","article_type":"original","article_processing_charge":"No","abstract":[{"text":"Rotavirus genomes are distributed between 11 distinct RNA molecules, all of which must be selectively copackaged during virus assembly. This likely occurs through sequence-specific RNA interactions facilitated by the RNA chaperone NSP2. Here, we report that NSP2 autoregulates its chaperone activity through its C-terminal region (CTR) that promotes RNA–RNA interactions by limiting its helix-unwinding activity. Unexpectedly, structural proteomics data revealed that the CTR does not directly interact with RNA, while accelerating RNA release from NSP2. Cryo–electron microscopy reconstructions of an NSP2–RNA complex reveal a highly conserved acidic patch on the CTR, which is poised toward the bound RNA. Virus replication was abrogated by charge-disrupting mutations within the acidic patch but completely restored by charge-preserving mutations. Mechanistic similarities between NSP2 and the unrelated bacterial RNA chaperone Hfq suggest that accelerating RNA dissociation while promoting intermolecular RNA interactions may be a widespread strategy of RNA chaperone recycling.","lang":"eng"}],"article_number":"e2100198118","language":[{"iso":"eng"}],"year":"2021","volume":118,"title":"Structural basis of rotavirus RNA chaperone displacement and RNA annealing","oa":1,"extern":"1","day":"06","publication_status":"published","doi":"10.1073/pnas.2100198118","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1073/pnas.2100198118"}]},{"citation":{"chicago":"Bravo, Jack Peter Kelly, Tyler L. Dangerfield, David W. Taylor, and Kenneth A. Johnson. “Remdesivir Is a Delayed Translocation Inhibitor of SARS-CoV-2 Replication.” Molecular Cell. Elsevier, 2021. https://doi.org/10.1016/j.molcel.2021.01.035.","short":"J.P.K. Bravo, T.L. Dangerfield, D.W. Taylor, K.A. Johnson, Molecular Cell 81 (2021) 1548–1552.e4.","mla":"Bravo, Jack Peter Kelly, et al. “Remdesivir Is a Delayed Translocation Inhibitor of SARS-CoV-2 Replication.” Molecular Cell, vol. 81, no. 7, Elsevier, 2021, p. 1548–1552.e4, doi:10.1016/j.molcel.2021.01.035.","ista":"Bravo JPK, Dangerfield TL, Taylor DW, Johnson KA. 2021. Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. Molecular Cell. 81(7), 1548–1552.e4.","ieee":"J. P. K. Bravo, T. L. Dangerfield, D. W. Taylor, and K. A. Johnson, “Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication,” Molecular Cell, vol. 81, no. 7. Elsevier, p. 1548–1552.e4, 2021.","apa":"Bravo, J. P. K., Dangerfield, T. L., Taylor, D. W., & Johnson, K. A. (2021). Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. Molecular Cell. Elsevier. https://doi.org/10.1016/j.molcel.2021.01.035","ama":"Bravo JPK, Dangerfield TL, Taylor DW, Johnson KA. Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. Molecular Cell. 2021;81(7):1548-1552.e4. doi:10.1016/j.molcel.2021.01.035"},"publisher":"Elsevier","date_created":"2024-03-20T10:42:53Z","page":"1548-1552.e4","month":"04","status":"public","date_published":"2021-04-01T00:00:00Z","quality_controlled":"1","_id":"15140","issue":"7","intvolume":" 81","publication_identifier":{"issn":["1097-2765"]},"external_id":{"pmid":["33631104"]},"author":[{"orcid":"0000-0003-0456-0753","full_name":"Bravo, Jack Peter Kelly","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","first_name":"Jack Peter Kelly","last_name":"Bravo"},{"full_name":"Dangerfield, Tyler L.","first_name":"Tyler L.","last_name":"Dangerfield"},{"last_name":"Taylor","first_name":"David W.","full_name":"Taylor, David W."},{"full_name":"Johnson, Kenneth A.","last_name":"Johnson","first_name":"Kenneth A."}],"pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","keyword":["Cell Biology","Molecular Biology"],"article_type":"original","article_processing_charge":"No","type":"journal_article","publication":"Molecular Cell","date_updated":"2024-06-04T06:00:56Z","scopus_import":"1","main_file_link":[{"url":"https://doi.org/10.1101/2020.12.14.422718 ","open_access":"1"}],"publication_status":"published","doi":"10.1016/j.molcel.2021.01.035","year":"2021","title":"Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication","volume":81,"extern":"1","oa":1,"day":"01","abstract":[{"lang":"eng","text":"Remdesivir is a nucleoside analog approved by the US FDA for treatment of COVID-19. Here, we present a 3.9-Å-resolution cryo-EM reconstruction of a remdesivir-stalled RNA-dependent RNA polymerase complex, revealing full incorporation of 3 copies of remdesivir monophosphate (RMP) and a partially incorporated fourth RMP in the active site. The structure reveals that RMP blocks RNA translocation after incorporation of 3 bases following RMP, resulting in delayed chain termination, which can guide the rational design of improved antiviral drugs."}],"language":[{"iso":"eng"}]}]