[{"corr_author":"1","fulldoi":"https://doi.org/10.7554/eLife.64543","ec_funded":1,"publication_identifier":{"eissn":["2050-084X"]},"project":[{"_id":"2578D616-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"648440","name":"Selective Barriers to Horizontal Gene Transfer"}],"file":[{"date_created":"2022-02-07T07:14:09Z","date_updated":"2022-02-07T07:14:09Z","checksum":"decdcdf600ff51e9a9703b49ca114170","file_id":"10739","access_level":"open_access","relation":"main_file","file_name":"2022_ELife_Lagator.pdf","content_type":"application/pdf","file_size":5604343,"success":1,"creator":"cchlebak"}],"date_published":"2022-01-26T00:00:00Z","license":"https://creativecommons.org/licenses/by/4.0/","day":"26","abstract":[{"lang":"eng","text":"Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we developed a biophysical model that accounts for multiple features of σ70 binding bacterial promoters to predict constitutive gene expression levels from any sequence. We experimentally and theoretically estimated that 10–20% of random sequences lead to expression and ~80% of non-expressing sequences are one mutation away from a functional promoter. The potential for generating expression from random sequences is so pervasive that selection acts against σ70-RNA polymerase binding sites even within inter-genic, promoter-containing regions. This pervasiveness of σ70-binding sites implies that emergence of promoters is not the limiting step in gene regulatory evolution. Ultimately, the inclusion of novel features of promoter function into a mechanistic model enabled not only more accurate predictions of gene expression levels, but also identified that promoters evolve more rapidly than previously thought."}],"publication_status":"published","quality_controlled":"1","type":"journal_article","scopus_import":"1","doi":"10.7554/eLife.64543","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"eLife","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"status":"public","file_date_updated":"2022-02-07T07:14:09Z","pmid":1,"oa":1,"title":"Predicting bacterial promoter function and evolution from random sequences","intvolume":"        11","external_id":{"pmid":["35080492"],"isi":["000751104400001"]},"_id":"10736","article_type":"original","publisher":"eLife Sciences Publications","volume":11,"citation":{"apa":"Lagator, M., Sarikas, S., Steinrück, M., Toledo-Aparicio, D., Bollback, J. P., Guet, C. C., &#38; Tkačik, G. (2022). Predicting bacterial promoter function and evolution from random sequences. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.64543\">https://doi.org/10.7554/eLife.64543</a>","short":"M. Lagator, S. Sarikas, M. Steinrück, D. Toledo-Aparicio, J.P. Bollback, C.C. Guet, G. Tkačik, ELife 11 (2022).","mla":"Lagator, Mato, et al. “Predicting Bacterial Promoter Function and Evolution from Random Sequences.” <i>ELife</i>, vol. 11, e64543, eLife Sciences Publications, 2022, doi:<a href=\"https://doi.org/10.7554/eLife.64543\">10.7554/eLife.64543</a>.","ista":"Lagator M, Sarikas S, Steinrück M, Toledo-Aparicio D, Bollback JP, Guet CC, Tkačik G. 2022. Predicting bacterial promoter function and evolution from random sequences. eLife. 11, e64543.","ama":"Lagator M, Sarikas S, Steinrück M, et al. Predicting bacterial promoter function and evolution from random sequences. <i>eLife</i>. 2022;11. doi:<a href=\"https://doi.org/10.7554/eLife.64543\">10.7554/eLife.64543</a>","chicago":"Lagator, Mato, Srdjan Sarikas, Magdalena Steinrück, David Toledo-Aparicio, Jonathan P Bollback, Calin C Guet, and Gašper Tkačik. “Predicting Bacterial Promoter Function and Evolution from Random Sequences.” <i>ELife</i>. eLife Sciences Publications, 2022. <a href=\"https://doi.org/10.7554/eLife.64543\">https://doi.org/10.7554/eLife.64543</a>.","ieee":"M. Lagator <i>et al.</i>, “Predicting bacterial promoter function and evolution from random sequences,” <i>eLife</i>, vol. 11. eLife Sciences Publications, 2022."},"date_created":"2022-02-06T23:01:32Z","article_processing_charge":"No","department":[{"_id":"CaGu"},{"_id":"GaTk"},{"_id":"NiBa"}],"isi":1,"month":"01","has_accepted_license":"1","acknowledgement":"We thank Hande Acar, Nicholas H Barton, Rok Grah, Tiago Paixao, Maros Pleska, Anna Staron, and Murat Tugrul for insightful comments and input on the manuscript. This work was supported by: Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant number 216779/Z/19/Z) to ML; IPC Grant from IST Austria to ML and SS; European Research Council Funding Programme 7 (2007–2013, grant agreement number 648440) to JPB.","author":[{"first_name":"Mato","full_name":"Lagator, Mato","id":"345D25EC-F248-11E8-B48F-1D18A9856A87","last_name":"Lagator"},{"first_name":"Srdjan","last_name":"Sarikas","id":"35F0286E-F248-11E8-B48F-1D18A9856A87","full_name":"Sarikas, Srdjan"},{"orcid":"0000-0003-1229-9719","first_name":"Magdalena","full_name":"Steinrück, Magdalena","id":"2C023F40-F248-11E8-B48F-1D18A9856A87","last_name":"Steinrück"},{"last_name":"Toledo-Aparicio","full_name":"Toledo-Aparicio, David","first_name":"David"},{"first_name":"Jonathan P","orcid":"0000-0002-4624-4612","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","last_name":"Bollback","full_name":"Bollback, Jonathan P"},{"first_name":"Calin C","orcid":"0000-0001-6220-2052","full_name":"Guet, Calin C","last_name":"Guet","id":"47F8433E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Tkačik","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","full_name":"Tkačik, Gašper","orcid":"0000-0002-6699-1455","first_name":"Gašper"}],"oa_version":"Published Version","year":"2022","ddc":["576"],"article_number":"e64543","date_updated":"2025-03-31T16:00:23Z"},{"year":"2022","oa_version":"Preprint","author":[{"last_name":"Takhanov","id":"2CCAC26C-F248-11E8-B48F-1D18A9856A87","full_name":"Takhanov, Rustem","first_name":"Rustem"},{"full_name":"Kolmogorov, Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kolmogorov","first_name":"Vladimir"}],"date_updated":"2024-10-09T21:01:33Z","main_file_link":[{"url":"https://arxiv.org/abs/1404.5475","open_access":"1"}],"month":"01","isi":1,"department":[{"_id":"VlKo"}],"issue":"1","article_type":"original","_id":"10737","external_id":{"isi":["000749997700015"],"arxiv":["1404.5475"]},"citation":{"chicago":"Takhanov, Rustem, and Vladimir Kolmogorov. “Combining Pattern-Based CRFs and Weighted Context-Free Grammars.” <i>Intelligent Data Analysis</i>. IOS Press, 2022. <a href=\"https://doi.org/10.3233/IDA-205623\">https://doi.org/10.3233/IDA-205623</a>.","ieee":"R. Takhanov and V. Kolmogorov, “Combining pattern-based CRFs and weighted context-free grammars,” <i>Intelligent Data Analysis</i>, vol. 26, no. 1. IOS Press, pp. 257–272, 2022.","short":"R. Takhanov, V. Kolmogorov, Intelligent Data Analysis 26 (2022) 257–272.","apa":"Takhanov, R., &#38; Kolmogorov, V. (2022). Combining pattern-based CRFs and weighted context-free grammars. <i>Intelligent Data Analysis</i>. IOS Press. <a href=\"https://doi.org/10.3233/IDA-205623\">https://doi.org/10.3233/IDA-205623</a>","ista":"Takhanov R, Kolmogorov V. 2022. Combining pattern-based CRFs and weighted context-free grammars. Intelligent Data Analysis. 26(1), 257–272.","mla":"Takhanov, Rustem, and Vladimir Kolmogorov. “Combining Pattern-Based CRFs and Weighted Context-Free Grammars.” <i>Intelligent Data Analysis</i>, vol. 26, no. 1, IOS Press, 2022, pp. 257–72, doi:<a href=\"https://doi.org/10.3233/IDA-205623\">10.3233/IDA-205623</a>.","ama":"Takhanov R, Kolmogorov V. Combining pattern-based CRFs and weighted context-free grammars. <i>Intelligent Data Analysis</i>. 2022;26(1):257-272. doi:<a href=\"https://doi.org/10.3233/IDA-205623\">10.3233/IDA-205623</a>"},"article_processing_charge":"No","volume":26,"date_created":"2022-02-06T23:01:32Z","publisher":"IOS Press","status":"public","arxiv":1,"title":"Combining pattern-based CRFs and weighted context-free grammars","intvolume":"        26","oa":1,"publication":"Intelligent Data Analysis","language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.3233/IDA-205623","scopus_import":"1","page":"257-272","date_published":"2022-01-14T00:00:00Z","abstract":[{"lang":"eng","text":"We consider two models for the sequence labeling (tagging) problem. The first one is a Pattern-Based Conditional Random Field (PB), in which the energy of a string (chain labeling) x=x1⁢…⁢xn∈Dn is a sum of terms over intervals [i,j] where each term is non-zero only if the substring xi⁢…⁢xj equals a prespecified word w∈Λ. The second model is a Weighted Context-Free Grammar (WCFG) frequently used for natural language processing. PB and WCFG encode local and non-local interactions respectively, and thus can be viewed as complementary. We propose a Grammatical Pattern-Based CRF model (GPB) that combines the two in a natural way. We argue that it has certain advantages over existing approaches such as the Hybrid model of Benedí and Sanchez that combines N-grams and WCFGs. The focus of this paper is to analyze the complexity of inference tasks in a GPB such as computing MAP. We present a polynomial-time algorithm for general GPBs and a faster version for a special case that we call Interaction Grammars."}],"day":"14","fulldoi":"https://doi.org/10.3233/IDA-205623","corr_author":"1","publication_identifier":{"eissn":["1571-4128"],"issn":["1088-467X"]}},{"publication_status":"published","type":"conference","quality_controlled":"1","scopus_import":"1","doi":"10.1109/bigdata52589.2021.9672003","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication":"2021 IEEE International Conference on Big Data","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1109/bigdata52589.2021.9672003","corr_author":"1","publication_identifier":{"isbn":["9781665439022"]},"date_published":"2022-01-13T00:00:00Z","page":"5185-5192","conference":{"location":"Orlando, FL, United States","start_date":"2021-12-15","end_date":"2021-12-18","name":"Big Data: International Conference on Big Data"},"day":"13","acknowledged_ssus":[{"_id":"ScienComp"}],"abstract":[{"text":"The digitalization of almost all aspects of our everyday lives has led to unprecedented amounts of data being freely available on the Internet. In particular social media platforms provide rich sources of user-generated data, though typically in unstructured form, and with high diversity, such as written in many different languages. Automatically identifying meaningful information in such big data resources and extracting it efficiently is one of the ongoing challenges of our time. A common step for this is sentiment analysis, which forms the foundation for tasks such as opinion mining or trend prediction. Unfortunately, publicly available tools for this task are almost exclusively available for English-language texts. Consequently, a large fraction of the Internet users, who do not communicate in English, are ignored in automatized studies, a phenomenon called rare-language discrimination.In this work we propose a technique to overcome this problem by a truly multi-lingual model, which can be trained automatically without linguistic knowledge or even the ability to read the many target languages. The main step is to combine self-annotation, specifically the use of emoticons as a proxy for labels, with multi-lingual sentence representations.To evaluate our method we curated several large datasets from data obtained via the free Twitter streaming API. The results show that our proposed multi-lingual training is able to achieve sentiment predictions at the same quality level for rare languages as for frequent ones, and in particular clearly better than what mono-lingual training achieves on the same data. ","lang":"eng"}],"department":[{"_id":"ChLa"}],"isi":1,"month":"01","author":[{"last_name":"Lampert","full_name":"Lampert, Jasmin","first_name":"Jasmin"},{"last_name":"Lampert","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","full_name":"Lampert, Christoph","orcid":"0000-0002-4561-241X","first_name":"Christoph"}],"acknowledgement":"This research was funded in parts by the FORTE program of the Austrian Research Promotion Agency (FFG) and the Federal Ministry of Agriculture, Regions and Tourism (BMLRT) as part of the AMMONIS project (grant no. 879705). The research was also supported by the Scientific Service Units (SSU) of IST Austria through resources provided by Scientific Computing (SciComp).","oa_version":"None","year":"2022","date_updated":"2024-10-21T06:01:53Z","status":"public","title":"Overcoming rare-language discrimination in multi-lingual sentiment analysis","external_id":{"isi":["000800559505036"]},"_id":"10752","publisher":"IEEE","date_created":"2022-02-10T14:08:23Z","citation":{"short":"J. Lampert, C. Lampert, in:, 2021 IEEE International Conference on Big Data, IEEE, 2022, pp. 5185–5192.","apa":"Lampert, J., &#38; Lampert, C. (2022). Overcoming rare-language discrimination in multi-lingual sentiment analysis. In <i>2021 IEEE International Conference on Big Data</i> (pp. 5185–5192). Orlando, FL, United States: IEEE. <a href=\"https://doi.org/10.1109/bigdata52589.2021.9672003\">https://doi.org/10.1109/bigdata52589.2021.9672003</a>","ama":"Lampert J, Lampert C. Overcoming rare-language discrimination in multi-lingual sentiment analysis. In: <i>2021 IEEE International Conference on Big Data</i>. IEEE; 2022:5185-5192. doi:<a href=\"https://doi.org/10.1109/bigdata52589.2021.9672003\">10.1109/bigdata52589.2021.9672003</a>","ista":"Lampert J, Lampert C. 2022. Overcoming rare-language discrimination in multi-lingual sentiment analysis. 2021 IEEE International Conference on Big Data. Big Data: International Conference on Big Data, 5185–5192.","mla":"Lampert, Jasmin, and Christoph Lampert. “Overcoming Rare-Language Discrimination in Multi-Lingual Sentiment Analysis.” <i>2021 IEEE International Conference on Big Data</i>, IEEE, 2022, pp. 5185–92, doi:<a href=\"https://doi.org/10.1109/bigdata52589.2021.9672003\">10.1109/bigdata52589.2021.9672003</a>.","chicago":"Lampert, Jasmin, and Christoph Lampert. “Overcoming Rare-Language Discrimination in Multi-Lingual Sentiment Analysis.” In <i>2021 IEEE International Conference on Big Data</i>, 5185–92. IEEE, 2022. <a href=\"https://doi.org/10.1109/bigdata52589.2021.9672003\">https://doi.org/10.1109/bigdata52589.2021.9672003</a>.","ieee":"J. Lampert and C. Lampert, “Overcoming rare-language discrimination in multi-lingual sentiment analysis,” in <i>2021 IEEE International Conference on Big Data</i>, Orlando, FL, United States, 2022, pp. 5185–5192."},"article_processing_charge":"No"},{"day":"02","abstract":[{"lang":"eng","text":"This is a comment on \"Meta-learning synaptic plasticity and memory addressing for continual familiarity detection.\" Neuron. 2022 Feb 2;110(3):544-557.e8."}],"date_published":"2022-02-02T00:00:00Z","page":"361-362","publication_identifier":{"eissn":["1097-4199"]},"corr_author":"1","fulldoi":"https://doi.org/10.1016/j.neuron.2022.01.014","language":[{"iso":"eng"}],"publication":"Neuron","doi":"10.1016/j.neuron.2022.01.014","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","quality_controlled":"1","publication_status":"published","publisher":"Elsevier","citation":{"short":"B.J. Confavreux, T.P. Vogels, Neuron 110 (2022) 361–362.","apa":"Confavreux, B. J., &#38; Vogels, T. P. (2022). A familiar thought: Machines that replace us? <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2022.01.014\">https://doi.org/10.1016/j.neuron.2022.01.014</a>","ista":"Confavreux BJ, Vogels TP. 2022. A familiar thought: Machines that replace us? Neuron. 110(3), 361–362.","ama":"Confavreux BJ, Vogels TP. A familiar thought: Machines that replace us? <i>Neuron</i>. 2022;110(3):361-362. doi:<a href=\"https://doi.org/10.1016/j.neuron.2022.01.014\">10.1016/j.neuron.2022.01.014</a>","mla":"Confavreux, Basile J., and Tim P. Vogels. “A Familiar Thought: Machines That Replace Us?” <i>Neuron</i>, vol. 110, no. 3, Elsevier, 2022, pp. 361–62, doi:<a href=\"https://doi.org/10.1016/j.neuron.2022.01.014\">10.1016/j.neuron.2022.01.014</a>.","chicago":"Confavreux, Basile J, and Tim P Vogels. “A Familiar Thought: Machines That Replace Us?” <i>Neuron</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.neuron.2022.01.014\">https://doi.org/10.1016/j.neuron.2022.01.014</a>.","ieee":"B. J. Confavreux and T. P. Vogels, “A familiar thought: Machines that replace us?,” <i>Neuron</i>, vol. 110, no. 3. Elsevier, pp. 361–362, 2022."},"article_processing_charge":"No","volume":110,"date_created":"2022-02-13T23:01:34Z","external_id":{"isi":["000751819100005"],"pmid":["35114107"]},"article_type":"letter_note","_id":"10753","title":"A familiar thought: Machines that replace us?","intvolume":"       110","oa":1,"status":"public","pmid":1,"ddc":["570"],"date_updated":"2026-06-18T08:47:45Z","author":[{"full_name":"Confavreux, Basile J","last_name":"Confavreux","id":"C7610134-B532-11EA-BD9F-F5753DDC885E","first_name":"Basile J"},{"first_name":"Tim P","orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels"}],"year":"2022","oa_version":"Published Version","issue":"3","department":[{"_id":"TiVo"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.neuron.2022.01.014"}],"month":"02","isi":1},{"pmid":1,"file_date_updated":"2022-02-14T07:46:30Z","status":"public","title":"Developing a mathematical model of intracellular Calcium dynamics for evaluating combined anticancer effects of afatinib and RP4010 in esophageal cancer","intvolume":"        23","oa":1,"article_type":"original","_id":"10754","external_id":{"pmid":["35163685"],"isi":["000754773500001"]},"article_processing_charge":"Yes","volume":23,"citation":{"ieee":"Y. Chang <i>et al.</i>, “Developing a mathematical model of intracellular Calcium dynamics for evaluating combined anticancer effects of afatinib and RP4010 in esophageal cancer,” <i>International Journal of Molecular Sciences</i>, vol. 23, no. 3. MDPI, 2022.","chicago":"Chang, Yan, Marah Funk, Souvik Roy, Elizabeth R Stephenson, Sangyong Choi, Hristo V. Kojouharov, Benito Chen, and Zui Pan. “Developing a Mathematical Model of Intracellular Calcium Dynamics for Evaluating Combined Anticancer Effects of Afatinib and RP4010 in Esophageal Cancer.” <i>International Journal of Molecular Sciences</i>. MDPI, 2022. <a href=\"https://doi.org/10.3390/ijms23031763\">https://doi.org/10.3390/ijms23031763</a>.","mla":"Chang, Yan, et al. “Developing a Mathematical Model of Intracellular Calcium Dynamics for Evaluating Combined Anticancer Effects of Afatinib and RP4010 in Esophageal Cancer.” <i>International Journal of Molecular Sciences</i>, vol. 23, no. 3, 1763, MDPI, 2022, doi:<a href=\"https://doi.org/10.3390/ijms23031763\">10.3390/ijms23031763</a>.","ista":"Chang Y, Funk M, Roy S, Stephenson ER, Choi S, Kojouharov HV, Chen B, Pan Z. 2022. Developing a mathematical model of intracellular Calcium dynamics for evaluating combined anticancer effects of afatinib and RP4010 in esophageal cancer. International Journal of Molecular Sciences. 23(3), 1763.","ama":"Chang Y, Funk M, Roy S, et al. Developing a mathematical model of intracellular Calcium dynamics for evaluating combined anticancer effects of afatinib and RP4010 in esophageal cancer. <i>International Journal of Molecular Sciences</i>. 2022;23(3). doi:<a href=\"https://doi.org/10.3390/ijms23031763\">10.3390/ijms23031763</a>","short":"Y. Chang, M. Funk, S. Roy, E.R. Stephenson, S. Choi, H.V. Kojouharov, B. Chen, Z. Pan, International Journal of Molecular Sciences 23 (2022).","apa":"Chang, Y., Funk, M., Roy, S., Stephenson, E. R., Choi, S., Kojouharov, H. V., … Pan, Z. (2022). Developing a mathematical model of intracellular Calcium dynamics for evaluating combined anticancer effects of afatinib and RP4010 in esophageal cancer. <i>International Journal of Molecular Sciences</i>. MDPI. <a href=\"https://doi.org/10.3390/ijms23031763\">https://doi.org/10.3390/ijms23031763</a>"},"date_created":"2022-02-13T23:01:35Z","publisher":"MDPI","month":"02","isi":1,"department":[{"_id":"HeEd"}],"has_accepted_license":"1","issue":"3","year":"2022","oa_version":"Published Version","author":[{"first_name":"Yan","last_name":"Chang","full_name":"Chang, Yan"},{"last_name":"Funk","full_name":"Funk, Marah","first_name":"Marah"},{"first_name":"Souvik","full_name":"Roy, Souvik","last_name":"Roy"},{"full_name":"Stephenson, Elizabeth R","last_name":"Stephenson","id":"2D04F932-F248-11E8-B48F-1D18A9856A87","first_name":"Elizabeth R","orcid":"0000-0002-6862-208X"},{"full_name":"Choi, Sangyong","last_name":"Choi","first_name":"Sangyong"},{"first_name":"Hristo V.","full_name":"Kojouharov, Hristo V.","last_name":"Kojouharov"},{"first_name":"Benito","full_name":"Chen, Benito","last_name":"Chen"},{"first_name":"Zui","full_name":"Pan, Zui","last_name":"Pan"}],"acknowledgement":"This work was partially supported by grants from National Institutes of Health (NIH) (R01 CA185055, S10OD0252300) and The University of Texas System STARs Award (to Z.P.),\r\nThe University of Texas at Arlington Interdisciplinary Research Program (to B.C., H.V.K. and Z.P.). ","date_updated":"2025-06-11T13:46:46Z","article_number":"1763","ddc":["510","576"],"fulldoi":"https://doi.org/10.3390/ijms23031763","publication_identifier":{"eissn":["1422-0067"],"issn":["1661-6596"]},"date_published":"2022-02-01T00:00:00Z","file":[{"content_type":"application/pdf","file_size":24416183,"relation":"main_file","file_name":"2022_IJMS_Chang.pdf","creator":"dernst","success":1,"date_created":"2022-02-14T07:46:30Z","date_updated":"2022-02-14T07:46:30Z","file_id":"10756","access_level":"open_access","checksum":"8890ad20c54e90dc58ad5ea97c902998"}],"abstract":[{"text":"Targeting dysregulated Ca2+ signaling in cancer cells is an emerging chemotherapy approach. We previously reported that store-operated Ca2+ entry (SOCE) blockers, such as RP4010, are promising antitumor drugs for esophageal cancer. As a tyrosine kinase inhibitor (TKI), afatinib received FDA approval to be used in targeted therapy for patients with EGFR mutation-positive cancers. While preclinical studies and clinical trials have shown that afatinib has benefits for esophageal cancer patients, it is not known whether a combination of afatinib and RP4010 could achieve better anticancer effects. Since TKI can alter intracellular Ca2+ dynamics through EGFR/phospholipase C-γ pathway, in this study, we evaluated the inhibitory effect of afatinib and RP4010 on intracellular Ca2+ oscillations in KYSE-150, a human esophageal squamous cell carcinoma cell line, using both experimental and mathematical simulations. Our mathematical simulation of Ca2+ oscillations could fit well with experimental data responding to afatinib or RP4010, both separately or in combination. Guided by simulation, we were able to identify a proper ratio of afatinib and RP4010 for combined treatment, and such a combination presented synergistic anticancer-effect evidence by experimental measurement of intracellular Ca2+ and cell proliferation. This intracellular Ca2+ dynamic-based mathematical simulation approach could be useful for a rapid and cost-effective evaluation of combined targeting therapy drugs.","lang":"eng"}],"day":"01","type":"journal_article","quality_controlled":"1","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.3390/ijms23031763","scopus_import":"1","publication":"International Journal of Molecular Sciences","language":[{"iso":"eng"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"}},{"date_published":"2022-01-19T00:00:00Z","file":[{"success":1,"creator":"dernst","file_name":"2022_JournalPhysicsA_Feliciangeli.pdf","relation":"main_file","content_type":"application/pdf","file_size":1132380,"checksum":"0875e562705563053d6dd98fba4d8578","file_id":"10757","access_level":"open_access","date_created":"2022-02-14T08:20:19Z","date_updated":"2022-02-14T08:20:19Z"}],"abstract":[{"lang":"eng","text":"We provide a definition of the effective mass for the classical polaron described by the Landau–Pekar (LP) equations. It is based on a novel variational principle, minimizing the energy functional over states with given (initial) velocity. The resulting formula for the polaron's effective mass agrees with the prediction by LP (1948 J. Exp. Theor. Phys. 18 419–423)."}],"day":"19","ec_funded":1,"fulldoi":"https://doi.org/10.1088/1751-8121/ac3947","corr_author":"1","project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Analysis of quantum many-body systems","grant_number":"694227"},{"_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","call_identifier":"H2020"}],"publication_identifier":{"issn":["1751-8113"],"eissn":["1751-8121"]},"publication":"Journal of Physics A: Mathematical and Theoretical","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"related_material":{"record":[{"status":"public","relation":"earlier_version","id":"9791"}]},"language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1088/1751-8121/ac3947","scopus_import":"1","article_type":"original","_id":"10755","external_id":{"arxiv":["2107.03720"]},"volume":55,"article_processing_charge":"Yes (via OA deal)","date_created":"2022-02-13T23:01:35Z","citation":{"ieee":"D. Feliciangeli, S. A. E. Rademacher, and R. Seiringer, “The effective mass problem for the Landau-Pekar equations,” <i>Journal of Physics A: Mathematical and Theoretical</i>, vol. 55, no. 1. IOP Publishing, 2022.","chicago":"Feliciangeli, Dario, Simone Anna Elvira Rademacher, and Robert Seiringer. “The Effective Mass Problem for the Landau-Pekar Equations.” <i>Journal of Physics A: Mathematical and Theoretical</i>. IOP Publishing, 2022. <a href=\"https://doi.org/10.1088/1751-8121/ac3947\">https://doi.org/10.1088/1751-8121/ac3947</a>.","mla":"Feliciangeli, Dario, et al. “The Effective Mass Problem for the Landau-Pekar Equations.” <i>Journal of Physics A: Mathematical and Theoretical</i>, vol. 55, no. 1, 015201, IOP Publishing, 2022, doi:<a href=\"https://doi.org/10.1088/1751-8121/ac3947\">10.1088/1751-8121/ac3947</a>.","ista":"Feliciangeli D, Rademacher SAE, Seiringer R. 2022. The effective mass problem for the Landau-Pekar equations. Journal of Physics A: Mathematical and Theoretical. 55(1), 015201.","ama":"Feliciangeli D, Rademacher SAE, Seiringer R. The effective mass problem for the Landau-Pekar equations. <i>Journal of Physics A: Mathematical and Theoretical</i>. 2022;55(1). doi:<a href=\"https://doi.org/10.1088/1751-8121/ac3947\">10.1088/1751-8121/ac3947</a>","short":"D. Feliciangeli, S.A.E. Rademacher, R. Seiringer, Journal of Physics A: Mathematical and Theoretical 55 (2022).","apa":"Feliciangeli, D., Rademacher, S. A. E., &#38; Seiringer, R. (2022). The effective mass problem for the Landau-Pekar equations. <i>Journal of Physics A: Mathematical and Theoretical</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1751-8121/ac3947\">https://doi.org/10.1088/1751-8121/ac3947</a>"},"publisher":"IOP Publishing","file_date_updated":"2022-02-14T08:20:19Z","status":"public","arxiv":1,"intvolume":"        55","title":"The effective mass problem for the Landau-Pekar equations","oa":1,"year":"2022","oa_version":"Published Version","author":[{"first_name":"Dario","orcid":"0000-0003-0754-8530","id":"41A639AA-F248-11E8-B48F-1D18A9856A87","last_name":"Feliciangeli","full_name":"Feliciangeli, Dario"},{"first_name":"Simone Anna Elvira","orcid":"0000-0001-5059-4466","last_name":"Rademacher","id":"856966FE-A408-11E9-977E-802DE6697425","full_name":"Rademacher, Simone Anna Elvira"},{"first_name":"Robert","orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"acknowledgement":"We thank Herbert Spohn for helpful comments. Funding from the European Union’s Horizon\r\n2020 research and innovation programme under the ERC Grant Agreement No. 694227\r\n(DF and RS) and under the Marie Skłodowska-Curie Grant Agreement No. 754411 (SR) is\r\ngratefully acknowledged.","date_updated":"2025-04-15T06:54:54Z","article_number":"015201","ddc":["510"],"month":"01","department":[{"_id":"RoSe"}],"has_accepted_license":"1","issue":"1"},{"doi":"10.1021/acsphyschemau.1c00050","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","type":"journal_article","publication_status":"published","related_material":{"link":[{"relation":"earlier_version","url":"https://www.biorxiv.org/content/10.1101/2021.12.14.472563"}]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"publication":"ACS Physical Chemistry Au","publication_identifier":{"eissn":["2694-2445"]},"project":[{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"corr_author":"1","fulldoi":"https://doi.org/10.1021/acsphyschemau.1c00050","day":"11","abstract":[{"text":"5-Carboxycytosine (5caC) is a rare epigenetic modification found in nucleic acids of all domains of life. Despite its sparse genomic abundance, 5caC is presumed to play essential regulatory roles in transcription, maintenance and base-excision processes in DNA. In this work, we utilize nuclear magnetic resonance (NMR) spectroscopy to address the effects of 5caC incorporation into canonical DNA strands at multiple pH and temperature conditions. Our results demonstrate that 5caC has a pH-dependent global destabilizing and a base-pair mobility enhancing local impact on dsDNA, albeit without any detectable influence on the ground-state B-DNA structure. Measurement of hybridization thermodynamics and kinetics of 5caC-bearing DNA duplexes highlighted how acidic environment (pH 5.8 and 4.7) destabilizes the double-stranded structure by ∼10–20 kJ mol–1 at 37 °C when compared to the same sample at neutral pH. Protonation of 5caC results in a lower activation energy for the dissociation process and a higher barrier for annealing. Studies on conformational exchange on the microsecond time scale regime revealed a sharply localized base-pair motion involving exclusively the modified site and its immediate surroundings. By direct comparison with canonical and 5-formylcytosine (5fC)-edited strands, we were able to address the impact of the two most oxidized naturally occurring cytosine derivatives in the genome. These insights on 5caC’s subtle sensitivity to acidic pH contribute to the long-standing questions of its capacity as a substrate in base excision repair processes and its purpose as an independent, stable epigenetic mark.","lang":"eng"}],"file":[{"date_created":"2022-07-29T07:53:20Z","date_updated":"2022-07-29T07:53:20Z","checksum":"5ce3f907848f5c7caf77f1adfe5826c6","file_id":"11692","access_level":"open_access","relation":"main_file","file_name":"2022_ACSPhysChemAU_Dubini.pdf","content_type":"application/pdf","file_size":2351220,"success":1,"creator":"dernst"}],"date_published":"2022-02-11T00:00:00Z","page":"237-246","issue":"3","has_accepted_license":"1","department":[{"_id":"NMR"}],"month":"02","ddc":["540"],"date_updated":"2025-04-15T06:53:09Z","acknowledgement":"We thank Markus Müller for valued discussions and Felix Xu for assistance in the measurement of UV/vis melting profiles. This work was supported in part by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – SFB 1309-325871075, EU-ITN LightDyNAmics (ID: 765266), the ERC-AG EpiR (ID: 741912), the Center for NanoScience, the Excellence Clusters CIPSM, and the Fonds der Chemischen Industrie. Open access funding provided by Institute of Science and Technology Austria (ISTA).\r\n\r\n","author":[{"last_name":"Dubini","full_name":"Dubini, Romeo C. A.","first_name":"Romeo C. A."},{"first_name":"Eva","last_name":"Korytiaková","full_name":"Korytiaková, Eva"},{"full_name":"Schinkel, Thea","last_name":"Schinkel","first_name":"Thea"},{"full_name":"Heinrichs, Pia","last_name":"Heinrichs","first_name":"Pia"},{"full_name":"Carell, Thomas","last_name":"Carell","first_name":"Thomas"},{"id":"c316e53f-b965-11eb-b128-bb26acc59c00","last_name":"Rovo","full_name":"Rovo, Petra","first_name":"Petra","orcid":"0000-0001-8729-7326"}],"oa_version":"Published Version","year":"2022","title":"1H NMR chemical exchange techniques reveal local and global effects of oxidized cytosine derivatives","intvolume":"         2","oa":1,"status":"public","file_date_updated":"2022-07-29T07:53:20Z","pmid":1,"publisher":"American Chemical Society","article_processing_charge":"Yes (via OA deal)","citation":{"short":"R.C.A. Dubini, E. Korytiaková, T. Schinkel, P. Heinrichs, T. Carell, P. Rovo, ACS Physical Chemistry Au 2 (2022) 237–246.","apa":"Dubini, R. C. A., Korytiaková, E., Schinkel, T., Heinrichs, P., Carell, T., &#38; Rovo, P. (2022). 1H NMR chemical exchange techniques reveal local and global effects of oxidized cytosine derivatives. <i>ACS Physical Chemistry Au</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsphyschemau.1c00050\">https://doi.org/10.1021/acsphyschemau.1c00050</a>","mla":"Dubini, Romeo C. A., et al. “1H NMR Chemical Exchange Techniques Reveal Local and Global Effects of Oxidized Cytosine Derivatives.” <i>ACS Physical Chemistry Au</i>, vol. 2, no. 3, American Chemical Society, 2022, pp. 237–46, doi:<a href=\"https://doi.org/10.1021/acsphyschemau.1c00050\">10.1021/acsphyschemau.1c00050</a>.","ama":"Dubini RCA, Korytiaková E, Schinkel T, Heinrichs P, Carell T, Rovo P. 1H NMR chemical exchange techniques reveal local and global effects of oxidized cytosine derivatives. <i>ACS Physical Chemistry Au</i>. 2022;2(3):237-246. doi:<a href=\"https://doi.org/10.1021/acsphyschemau.1c00050\">10.1021/acsphyschemau.1c00050</a>","ista":"Dubini RCA, Korytiaková E, Schinkel T, Heinrichs P, Carell T, Rovo P. 2022. 1H NMR chemical exchange techniques reveal local and global effects of oxidized cytosine derivatives. ACS Physical Chemistry Au. 2(3), 237–246.","chicago":"Dubini, Romeo C. A., Eva Korytiaková, Thea Schinkel, Pia Heinrichs, Thomas Carell, and Petra Rovo. “1H NMR Chemical Exchange Techniques Reveal Local and Global Effects of Oxidized Cytosine Derivatives.” <i>ACS Physical Chemistry Au</i>. American Chemical Society, 2022. <a href=\"https://doi.org/10.1021/acsphyschemau.1c00050\">https://doi.org/10.1021/acsphyschemau.1c00050</a>.","ieee":"R. C. A. Dubini, E. Korytiaková, T. Schinkel, P. Heinrichs, T. Carell, and P. Rovo, “1H NMR chemical exchange techniques reveal local and global effects of oxidized cytosine derivatives,” <i>ACS Physical Chemistry Au</i>, vol. 2, no. 3. American Chemical Society, pp. 237–246, 2022."},"date_created":"2022-02-16T11:18:21Z","volume":2,"external_id":{"pmid":["35637781"]},"article_type":"original","_id":"10758"},{"page":"120","date_published":"2022-02-21T00:00:00Z","file":[{"creator":"wrzadkow","content_type":"application/zip","file_size":17668233,"file_name":"Rzadkowski_thesis_final_source.zip","relation":"source_file","file_id":"10785","access_level":"closed","checksum":"0fc54ad1eaede879c665ac9b53c93e22","date_created":"2022-02-21T13:58:16Z","date_updated":"2022-02-22T07:20:12Z"},{"relation":"main_file","file_name":"Rzadkowski_thesis_final.pdf","content_type":"application/pdf","file_size":13307331,"success":1,"creator":"wrzadkow","date_created":"2022-02-21T14:02:54Z","date_updated":"2022-02-21T14:02:54Z","checksum":"22d2d7af37ca31f6b1730c26cac7bced","file_id":"10786","access_level":"open_access"}],"abstract":[{"text":"In this Thesis, I study composite quantum impurities with variational techniques, both inspired by machine learning as well as fully analytic. I supplement this with exploration of other applications of machine learning, in particular artificial neural networks, in many-body physics. In Chapters 3 and 4, I study quasiparticle systems with variational approach. I derive a Hamiltonian describing the angulon quasiparticle in the presence of a magnetic field. I apply analytic variational treatment to this Hamiltonian. Then, I introduce a variational approach for non-additive systems, based on artificial neural networks. I exemplify this approach on the example of the polaron quasiparticle (Fröhlich Hamiltonian). In Chapter 5, I continue using artificial neural networks, albeit in a different setting. I apply artificial neural networks to detect phases from snapshots of two types physical systems. Namely, I study Monte Carlo snapshots of multilayer classical spin models as well as molecular dynamics maps of colloidal systems. The main type of networks that I use here are convolutional neural networks, known for their applicability to image data.","lang":"eng"}],"OA_place":"publisher","day":"21","fulldoi":"https://doi.org/10.15479/at:ista:10759","ec_funded":1,"corr_author":"1","supervisor":[{"full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","last_name":"Lemeshko","first_name":"Mikhail","orcid":"0000-0002-6990-7802"}],"project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020"}],"publication_identifier":{"issn":["2663-337X"]},"related_material":{"record":[{"relation":"part_of_dissertation","id":"10762","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"415"},{"status":"public","id":"8644","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"7956"}]},"language":[{"iso":"eng"}],"publication_status":"published","type":"dissertation","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.15479/at:ista:10759","_id":"10759","degree_awarded":"PhD","article_processing_charge":"No","date_created":"2022-02-16T13:27:37Z","citation":{"apa":"Rzadkowski, W. (2022). <i>Analytic and machine learning approaches to composite quantum impurities</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:10759\">https://doi.org/10.15479/at:ista:10759</a>","short":"W. Rzadkowski, Analytic and Machine Learning Approaches to Composite Quantum Impurities, Institute of Science and Technology Austria, 2022.","mla":"Rzadkowski, Wojciech. <i>Analytic and Machine Learning Approaches to Composite Quantum Impurities</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:10759\">10.15479/at:ista:10759</a>.","ama":"Rzadkowski W. Analytic and machine learning approaches to composite quantum impurities. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:10759\">10.15479/at:ista:10759</a>","ista":"Rzadkowski W. 2022. Analytic and machine learning approaches to composite quantum impurities. Institute of Science and Technology Austria.","chicago":"Rzadkowski, Wojciech. “Analytic and Machine Learning Approaches to Composite Quantum Impurities.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:10759\">https://doi.org/10.15479/at:ista:10759</a>.","ieee":"W. Rzadkowski, “Analytic and machine learning approaches to composite quantum impurities,” Institute of Science and Technology Austria, 2022."},"publisher":"Institute of Science and Technology Austria","file_date_updated":"2022-02-22T07:20:12Z","status":"public","oa":1,"title":"Analytic and machine learning approaches to composite quantum impurities","oa_version":"Published Version","year":"2022","author":[{"last_name":"Rzadkowski","id":"48C55298-F248-11E8-B48F-1D18A9856A87","full_name":"Rzadkowski, Wojciech","orcid":"0000-0002-1106-4419","first_name":"Wojciech"}],"date_updated":"2026-06-18T19:29:09Z","ddc":["530"],"month":"02","department":[{"_id":"GradSch"},{"_id":"MiLe"}],"alternative_title":["ISTA Thesis"],"has_accepted_license":"1"},{"publication_identifier":{"eissn":["2041-1723"]},"fulldoi":"https://doi.org/10.1038/s41467-022-28404-7","abstract":[{"text":"AMPA-type glutamate receptors (AMPARs) mediate rapid signal transmission at excitatory\r\nsynapses in the brain. Glutamate binding to the receptor’s ligand-binding domains (LBDs)\r\nleads to ion channel activation and desensitization. Gating kinetics shape synaptic transmission\r\nand are strongly modulated by transmembrane AMPAR regulatory proteins (TARPs)\r\nthrough currently incompletely resolved mechanisms. Here, electron cryo-microscopy\r\nstructures of the GluA1/2 TARP-γ8 complex, in both open and desensitized states\r\n(at 3.5 Å), reveal state-selective engagement of the LBDs by the large TARP-γ8 loop (‘β1’),\r\nelucidating how this TARP stabilizes specific gating states. We further show how TARPs alter\r\nchannel rectification, by interacting with the pore helix of the selectivity filter. Lastly, we\r\nreveal that the Q/R-editing site couples the channel constriction at the filter entrance to the\r\ngate, and forms the major cation binding site in the conduction path. Our results provide a\r\nmechanistic framework of how TARPs modulate AMPAR gating and conductance.","lang":"eng"}],"day":"08","file":[{"success":1,"creator":"dernst","relation":"main_file","file_name":"2022_NatureCommunications_Herguedas.pdf","file_size":2625540,"content_type":"application/pdf","checksum":"d86ee8eabe8b794730729ffbb1a8832e","access_level":"open_access","file_id":"10778","date_updated":"2022-02-21T07:59:32Z","date_created":"2022-02-21T07:59:32Z"}],"date_published":"2022-02-08T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.1038/s41467-022-28404-7","scopus_import":"1","type":"journal_article","quality_controlled":"1","publication_status":"published","language":[{"iso":"eng"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication":"Nature Communications","title":"Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor","intvolume":"        13","oa":1,"pmid":1,"file_date_updated":"2022-02-21T07:59:32Z","status":"public","citation":{"apa":"Herguedas, B., Kohegyi, B. K., Dohrke, J. N., Watson, J., Zhang, D., Ho, H., … Greger, I. H. (2022). Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-28404-7\">https://doi.org/10.1038/s41467-022-28404-7</a>","short":"B. Herguedas, B.K. Kohegyi, J.N. Dohrke, J. Watson, D. Zhang, H. Ho, S.A. Shaikh, R. Lape, J.M. Krieger, I.H. Greger, Nature Communications 13 (2022).","ista":"Herguedas B, Kohegyi BK, Dohrke JN, Watson J, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH. 2022. Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor. Nature Communications. 13, 734.","ama":"Herguedas B, Kohegyi BK, Dohrke JN, et al. Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-28404-7\">10.1038/s41467-022-28404-7</a>","mla":"Herguedas, Beatriz, et al. “Mechanisms Underlying TARP Modulation of the GluA1/2-Γ8 AMPA Receptor.” <i>Nature Communications</i>, vol. 13, 734, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-28404-7\">10.1038/s41467-022-28404-7</a>.","chicago":"Herguedas, Beatriz, Bianka K. Kohegyi, Jan Niklas Dohrke, Jake Watson, Danyang Zhang, Hinze Ho, Saher A. Shaikh, Remigijus Lape, James M. Krieger, and Ingo H. Greger. “Mechanisms Underlying TARP Modulation of the GluA1/2-Γ8 AMPA Receptor.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-28404-7\">https://doi.org/10.1038/s41467-022-28404-7</a>.","ieee":"B. Herguedas <i>et al.</i>, “Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022."},"date_created":"2022-02-20T23:01:30Z","article_processing_charge":"No","volume":13,"publisher":"Springer Nature","article_type":"original","_id":"10763","external_id":{"pmid":["35136046"],"isi":["000757297200008"]},"has_accepted_license":"1","month":"02","isi":1,"department":[{"_id":"PeJo"}],"date_updated":"2026-04-02T12:14:43Z","article_number":"734","ddc":["570"],"oa_version":"Published Version","year":"2022","acknowledgement":"We thank Ondrej Cais for critical reading of the manuscript. We are grateful to LMB\r\nscientific computing and the EM facility for support, Paul Emsley for help with model\r\nbuilding and Takanori Nakane for helpful comments with Relion 3.1. This work was\r\nsupported by grants from the Medical Research Council (MC_U105174197) and BBSRC\r\n(BB/N002113/1) to I.H.G, and grants from the MCIN/AEI/ 10.13039/501100011033 and\r\n“ESF Investing in your future” to B.H (PID2019-106284GA-I00 and RYC2018-025720-I).","author":[{"first_name":"Beatriz","last_name":"Herguedas","full_name":"Herguedas, Beatriz"},{"first_name":"Bianka K.","last_name":"Kohegyi","full_name":"Kohegyi, Bianka K."},{"first_name":"Jan Niklas","full_name":"Dohrke, Jan Niklas","last_name":"Dohrke"},{"orcid":"0000-0002-8698-3823","first_name":"Jake","last_name":"Watson","id":"63836096-4690-11EA-BD4E-32803DDC885E","full_name":"Watson, Jake"},{"last_name":"Zhang","full_name":"Zhang, Danyang","first_name":"Danyang"},{"first_name":"Hinze","full_name":"Ho, Hinze","last_name":"Ho"},{"first_name":"Saher A.","full_name":"Shaikh, Saher A.","last_name":"Shaikh"},{"first_name":"Remigijus","last_name":"Lape","full_name":"Lape, Remigijus"},{"last_name":"Krieger","full_name":"Krieger, James M.","first_name":"James M."},{"full_name":"Greger, Ingo H.","last_name":"Greger","first_name":"Ingo H."}]},{"day":"08","abstract":[{"text":"Presynaptic glutamate replenishment is fundamental to brain function. In high activity regimes, such as epileptic episodes, this process is thought to rely on the glutamate-glutamine cycle between neurons and astrocytes. However the presence of an astroglial glutamine supply, as well as its functional relevance in vivo in the healthy brain remain controversial, partly due to a lack of tools that can directly examine glutamine transfer. Here, we generated a fluorescent probe that tracks glutamine in live cells, which provides direct visual evidence of an activity-dependent glutamine supply from astroglial networks to presynaptic structures under physiological conditions. This mobilization is mediated by connexin43, an astroglial protein with both gap-junction and hemichannel functions, and is essential for synaptic transmission and object recognition memory. Our findings uncover an indispensable recruitment of astroglial glutamine in physiological synaptic activity and memory via an unconventional pathway, thus providing an astrocyte basis for cognitive processes.","lang":"eng"}],"date_published":"2022-02-08T00:00:00Z","file":[{"date_updated":"2022-02-21T07:51:33Z","date_created":"2022-02-21T07:51:33Z","access_level":"open_access","file_id":"10777","checksum":"51d580aff2327dd957946208a9749e1a","file_size":7910519,"content_type":"application/pdf","file_name":"2022_NatureCommunications_Cheung.pdf","relation":"main_file","creator":"dernst","success":1}],"publication_identifier":{"eissn":["2041-1723"]},"fulldoi":"https://doi.org/10.1038/s41467-022-28331-7","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"publication":"Nature Communications","scopus_import":"1","doi":"10.1038/s41467-022-28331-7","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_status":"published","type":"journal_article","quality_controlled":"1","publisher":"Springer Nature","article_processing_charge":"No","volume":13,"date_created":"2022-02-20T23:01:30Z","citation":{"ama":"Cheung GT, Bataveljic D, Visser J, et al. Physiological synaptic activity and recognition memory require astroglial glutamine. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-28331-7\">10.1038/s41467-022-28331-7</a>","ista":"Cheung GT, Bataveljic D, Visser J, Kumar N, Moulard J, Dallérac G, Mozheiko D, Rollenhagen A, Ezan P, Mongin C, Chever O, Bemelmans AP, Lübke J, Leray I, Rouach N. 2022. Physiological synaptic activity and recognition memory require astroglial glutamine. Nature Communications. 13, 753.","mla":"Cheung, Giselle T., et al. “Physiological Synaptic Activity and Recognition Memory Require Astroglial Glutamine.” <i>Nature Communications</i>, vol. 13, 753, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-28331-7\">10.1038/s41467-022-28331-7</a>.","apa":"Cheung, G. T., Bataveljic, D., Visser, J., Kumar, N., Moulard, J., Dallérac, G., … Rouach, N. (2022). Physiological synaptic activity and recognition memory require astroglial glutamine. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-28331-7\">https://doi.org/10.1038/s41467-022-28331-7</a>","short":"G.T. Cheung, D. Bataveljic, J. Visser, N. Kumar, J. Moulard, G. Dallérac, D. Mozheiko, A. Rollenhagen, P. Ezan, C. Mongin, O. Chever, A.P. Bemelmans, J. Lübke, I. Leray, N. Rouach, Nature Communications 13 (2022).","ieee":"G. T. Cheung <i>et al.</i>, “Physiological synaptic activity and recognition memory require astroglial glutamine,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","chicago":"Cheung, Giselle T, Danijela Bataveljic, Josien Visser, Naresh Kumar, Julien Moulard, Glenn Dallérac, Daria Mozheiko, et al. “Physiological Synaptic Activity and Recognition Memory Require Astroglial Glutamine.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-28331-7\">https://doi.org/10.1038/s41467-022-28331-7</a>."},"external_id":{"isi":["000757297200017"],"pmid":["35136061"]},"_id":"10764","article_type":"original","oa":1,"intvolume":"        13","title":"Physiological synaptic activity and recognition memory require astroglial glutamine","status":"public","pmid":1,"file_date_updated":"2022-02-21T07:51:33Z","ddc":["570"],"article_number":"753","date_updated":"2026-04-02T12:22:38Z","author":[{"orcid":"0000-0001-8457-2572","first_name":"Giselle T","full_name":"Cheung, Giselle T","id":"471195F6-F248-11E8-B48F-1D18A9856A87","last_name":"Cheung"},{"full_name":"Bataveljic, Danijela","last_name":"Bataveljic","first_name":"Danijela"},{"first_name":"Josien","full_name":"Visser, Josien","last_name":"Visser"},{"last_name":"Kumar","full_name":"Kumar, Naresh","first_name":"Naresh"},{"first_name":"Julien","full_name":"Moulard, Julien","last_name":"Moulard"},{"full_name":"Dallérac, Glenn","last_name":"Dallérac","first_name":"Glenn"},{"last_name":"Mozheiko","full_name":"Mozheiko, Daria","first_name":"Daria"},{"last_name":"Rollenhagen","full_name":"Rollenhagen, Astrid","first_name":"Astrid"},{"full_name":"Ezan, Pascal","last_name":"Ezan","first_name":"Pascal"},{"full_name":"Mongin, Cédric","last_name":"Mongin","first_name":"Cédric"},{"full_name":"Chever, Oana","last_name":"Chever","first_name":"Oana"},{"last_name":"Bemelmans","full_name":"Bemelmans, Alexis Pierre","first_name":"Alexis Pierre"},{"full_name":"Lübke, Joachim","last_name":"Lübke","first_name":"Joachim"},{"first_name":"Isabelle","full_name":"Leray, Isabelle","last_name":"Leray"},{"first_name":"Nathalie","full_name":"Rouach, Nathalie","last_name":"Rouach"}],"acknowledgement":"We thank D. Mazaud and. J. Cazères for technical assistance. This work was supported by grants from the European Research Council (Consolidator grant #683154) and European Union’s Horizon 2020 research and innovation program (Marie Sklodowska-Curie Innovative Training Networks, grant #722053, EU-GliaPhD) to N.R. and from FP7-PEOPLE Marie Curie Intra-European Fellowship for career development (grant #622289) to G.C.","year":"2022","oa_version":"Published Version","has_accepted_license":"1","department":[{"_id":"SiHi"}],"isi":1,"month":"02"},{"acknowledgement":"The authors apologize to those researchers whose work was not cited. In addition, exciting topics such as PIN polarization in context of phyllotaxis, shoot branching and termination of gravitropic bending, or role of additional auxin transporters could not have been included owing to lack of space. This work was supported by the Czech Science Foundation GAČR (GA18-26981S). The authors also acknowledge the EMBO for supporting J.H. with a long-term fellowship (ALTF217-2021).","author":[{"first_name":"Jakub","orcid":"0000-0003-2140-7195","id":"4800CC20-F248-11E8-B48F-1D18A9856A87","last_name":"Hajny","full_name":"Hajny, Jakub"},{"orcid":"0000-0002-0471-8285","first_name":"Shutang","last_name":"Tan","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","full_name":"Tan, Shutang"},{"first_name":"Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří"}],"oa_version":"Published Version","year":"2022","ddc":["580"],"date_updated":"2024-10-09T21:01:37Z","article_number":"102174","department":[{"_id":"JiFr"}],"month":"02","isi":1,"issue":"2","has_accepted_license":"1","external_id":{"isi":["000758724700004"],"pmid":["35123880"]},"article_type":"original","_id":"10768","publisher":"Elsevier","date_created":"2022-02-20T23:01:32Z","citation":{"ieee":"J. Hajny, S. Tan, and J. Friml, “Auxin canalization: From speculative models toward molecular players,” <i>Current Opinion in Plant Biology</i>, vol. 65, no. 2. Elsevier, 2022.","chicago":"Hajny, Jakub, Shutang Tan, and Jiří Friml. “Auxin Canalization: From Speculative Models toward Molecular Players.” <i>Current Opinion in Plant Biology</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.pbi.2022.102174\">https://doi.org/10.1016/j.pbi.2022.102174</a>.","ista":"Hajny J, Tan S, Friml J. 2022. Auxin canalization: From speculative models toward molecular players. Current Opinion in Plant Biology. 65(2), 102174.","mla":"Hajny, Jakub, et al. “Auxin Canalization: From Speculative Models toward Molecular Players.” <i>Current Opinion in Plant Biology</i>, vol. 65, no. 2, 102174, Elsevier, 2022, doi:<a href=\"https://doi.org/10.1016/j.pbi.2022.102174\">10.1016/j.pbi.2022.102174</a>.","ama":"Hajny J, Tan S, Friml J. Auxin canalization: From speculative models toward molecular players. <i>Current Opinion in Plant Biology</i>. 2022;65(2). doi:<a href=\"https://doi.org/10.1016/j.pbi.2022.102174\">10.1016/j.pbi.2022.102174</a>","apa":"Hajny, J., Tan, S., &#38; Friml, J. (2022). Auxin canalization: From speculative models toward molecular players. <i>Current Opinion in Plant Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.pbi.2022.102174\">https://doi.org/10.1016/j.pbi.2022.102174</a>","short":"J. Hajny, S. Tan, J. Friml, Current Opinion in Plant Biology 65 (2022)."},"volume":65,"article_processing_charge":"Yes (via OA deal)","status":"public","file_date_updated":"2022-03-10T13:34:09Z","pmid":1,"title":"Auxin canalization: From speculative models toward molecular players","intvolume":"        65","oa":1,"publication":"Current Opinion in Plant Biology","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","publication_status":"published","doi":"10.1016/j.pbi.2022.102174","scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","file":[{"creator":"dernst","success":1,"file_size":820322,"content_type":"application/pdf","file_name":"2022_CurrentOpPlantBiology_Hajny.pdf","relation":"main_file","access_level":"open_access","file_id":"10844","checksum":"f1ee02b6fb4200934eeb31fa69120885","date_updated":"2022-03-10T13:34:09Z","date_created":"2022-03-10T13:34:09Z"}],"date_published":"2022-02-01T00:00:00Z","day":"01","abstract":[{"text":"Among the most fascinated properties of the plant hormone auxin is its ability to promote formation of its own directional transport routes. These gradually narrowing auxin channels form from the auxin source toward the sink and involve coordinated, collective polarization of individual cells. Once established, the channels provide positional information, along which new vascular strands form, for example, during organogenesis, regeneration, or leave venation. The main prerequisite of this still mysterious auxin canalization mechanism is a feedback between auxin signaling and its directional transport. This is manifested by auxin-induced re-arrangements of polar, subcellular localization of PIN-FORMED (PIN) auxin exporters. Immanent open questions relate to how position of auxin source and sink as well as tissue context are sensed and translated into tissue polarization and how cells communicate to polarize coordinately. Recently, identification of the first molecular players opens new avenues into molecular studies of this intriguing example of self-organizing plant development.","lang":"eng"}],"corr_author":"1","fulldoi":"https://doi.org/10.1016/j.pbi.2022.102174","publication_identifier":{"issn":["1369-5266"]}},{"issue":"4","OA_type":"gold","has_accepted_license":"1","department":[{"_id":"MaSe"}],"month":"01","ddc":["530"],"date_updated":"2026-04-02T12:30:12Z","author":[{"full_name":"Daguerre, L.","last_name":"Daguerre","first_name":"L."},{"full_name":"Torroba, G.","last_name":"Torroba","first_name":"G."},{"first_name":"Raimel A","orcid":"0000-0002-5383-2869","id":"CE680B90-D85A-11E9-B684-C920E6697425","last_name":"Medina Ramos","full_name":"Medina Ramos, Raimel A"},{"last_name":"Solís","full_name":"Solís, M.","first_name":"M."}],"acknowledgement":"Se agradece a Horacio Casini por distintas discusiones y comentarios a lo largo del trabajo. LD cuenta con el apoyo de CNEA y UNCuyo, Inst. GT cuenta con el apoyo de CONICET,\r\nANPCyT, CNEA, y UNCuyo, Inst. Balseiro. RM cuenta con el apoyo de IST Austria. MS cuenta con el apoyode CONICET y UNCuyo, Inst. Balseiro. También se agradece a la Asociación Argentina de Física por la posibilidad de presentar este artículo en el marco de una Mención Especial por el Premio Luis Másperi 2020.","oa_version":"Published Version","year":"2022","oa":1,"title":"Non relativistic quantum field theory: Dynamics and irreversibility","DOAJ_listed":"1","intvolume":"        32","status":"public","file_date_updated":"2022-02-21T09:32:44Z","publisher":"Asociación Física Argentina","citation":{"chicago":"Daguerre, L., G. Torroba, Raimel A Medina Ramos, and M. Solís. “Non relativistic quantum field theory: Dynamics and irreversibility.” <i>Anales de la Asociacion Fisica Argentina</i>. Asociación Física Argentina, 2022. <a href=\"https://doi.org/10.31527/analesafa.2021.32.4.93\">https://doi.org/10.31527/analesafa.2021.32.4.93</a>.","ieee":"L. Daguerre, G. Torroba, R. A. Medina Ramos, and M. Solís, “Non relativistic quantum field theory: Dynamics and irreversibility,” <i>Anales de la Asociacion Fisica Argentina</i>, vol. 32, no. 4. Asociación Física Argentina, pp. 93–98, 2022.","apa":"Daguerre, L., Torroba, G., Medina Ramos, R. A., &#38; Solís, M. (2022). Non relativistic quantum field theory: Dynamics and irreversibility. <i>Anales de la Asociacion Fisica Argentina</i>. Asociación Física Argentina. <a href=\"https://doi.org/10.31527/analesafa.2021.32.4.93\">https://doi.org/10.31527/analesafa.2021.32.4.93</a>","short":"L. Daguerre, G. Torroba, R.A. Medina Ramos, M. Solís, Anales de la Asociacion Fisica Argentina 32 (2022) 93–98.","ista":"Daguerre L, Torroba G, Medina Ramos RA, Solís M. 2022. Non relativistic quantum field theory: Dynamics and irreversibility. Anales de la Asociacion Fisica Argentina. 32(4), 93–98.","ama":"Daguerre L, Torroba G, Medina Ramos RA, Solís M. Non relativistic quantum field theory: Dynamics and irreversibility. <i>Anales de la Asociacion Fisica Argentina</i>. 2022;32(4):93-98. doi:<a href=\"https://doi.org/10.31527/analesafa.2021.32.4.93\">10.31527/analesafa.2021.32.4.93</a>","mla":"Daguerre, L., et al. “Non relativistic quantum field theory: Dynamics and irreversibility.” <i>Anales de la Asociacion Fisica Argentina</i>, vol. 32, no. 4, Asociación Física Argentina, 2022, pp. 93–98, doi:<a href=\"https://doi.org/10.31527/analesafa.2021.32.4.93\">10.31527/analesafa.2021.32.4.93</a>."},"article_processing_charge":"No","date_created":"2022-02-20T23:01:32Z","volume":32,"_id":"10769","article_type":"original","scopus_import":"1","doi":"10.31527/analesafa.2021.32.4.93","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_status":"published","type":"journal_article","quality_controlled":"1","language":[{"iso":"spa"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication":"Anales de la Asociacion Fisica Argentina","publication_identifier":{"eissn":["1850-1168"]},"fulldoi":"https://doi.org/10.31527/analesafa.2021.32.4.93","OA_place":"publisher","day":"13","abstract":[{"lang":"eng","text":"studiamos aspectos de Teoría Cuántica de Campos a densidad finita usando técnicas y conceptos de información cuántica. Nos enfocamos en fermiones de Dirac masivos con potencial químico en 1+1 dimensiones espacio-temporales. Usando la entropía de entrelazamiento en un intervalo, construimos la función c entrópica que es finita. Esta función c no es monótona, e incorpora el entrelazamiento de largo alcance proveniente de la superficie de Fermi. Motivados por trabajos previos de modelos en la red, calculamos numéricamente las entropías de Renyi y encontramos oscilaciones de Friedel. Seguidamente, analizamos la información mutua como una medida de correlación entre diferentes regiones. Usando una expansión de distancia grande desarrollada por Cardy, argumentamos que la información mutua detecta las correlaciones inducidas por la superficie de Fermi todavía al orden dominante en la expansión. Finalmente, analizamos la entropía relativa y sus generalizaciones de Renyi para distinguir estados con diferente carga. Encontramos que estados en diferentes sectores de superselección dan origen a un comportamiento super-extensivo en la entropía relativa."}],"file":[{"access_level":"open_access","file_id":"10782","checksum":"ca66a3017205677c5b4d22b3bb74fb0b","date_updated":"2022-02-21T09:32:44Z","date_created":"2022-02-21T09:32:44Z","creator":"dernst","success":1,"file_size":4505751,"content_type":"application/pdf","file_name":"2022_AnalesAFA_Daguerre.pdf","relation":"main_file"}],"date_published":"2022-01-13T00:00:00Z","page":"93-98"},{"publication":"Advanced Materials","language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","publication_status":"published","doi":"10.1002/adma.202106629","scopus_import":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2022-04-01T00:00:00Z","day":"01","abstract":[{"text":"A critical overview of the theory of the chirality-induced spin selectivity (CISS) effect, that is, phenomena in which the chirality of molecular species imparts significant spin selectivity to various electron processes, is provided. Based on discussions in a recently held workshop, and further work published since, the status of CISS effects—in electron transmission, electron transport, and chemical reactions—is reviewed. For each, a detailed discussion of the state-of-the-art in theoretical understanding is provided and remaining challenges and research opportunities are identified.","lang":"eng"}],"fulldoi":"https://doi.org/10.1002/adma.202106629","publication_identifier":{"issn":["0935-9648"],"eissn":["1521-4095"]},"author":[{"full_name":"Evers, Ferdinand","last_name":"Evers","first_name":"Ferdinand"},{"full_name":"Aharony, Amnon","last_name":"Aharony","first_name":"Amnon"},{"first_name":"Nir","full_name":"Bar-Gill, Nir","last_name":"Bar-Gill"},{"first_name":"Ora","full_name":"Entin-Wohlman, Ora","last_name":"Entin-Wohlman"},{"first_name":"Per","last_name":"Hedegård","full_name":"Hedegård, Per"},{"last_name":"Hod","full_name":"Hod, Oded","first_name":"Oded"},{"first_name":"Pavel","full_name":"Jelinek, Pavel","last_name":"Jelinek"},{"last_name":"Kamieniarz","full_name":"Kamieniarz, Grzegorz","first_name":"Grzegorz"},{"full_name":"Lemeshko, Mikhail","last_name":"Lemeshko","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail","orcid":"0000-0002-6990-7802"},{"first_name":"Karen","full_name":"Michaeli, Karen","last_name":"Michaeli"},{"last_name":"Mujica","full_name":"Mujica, Vladimiro","first_name":"Vladimiro"},{"full_name":"Naaman, Ron","last_name":"Naaman","first_name":"Ron"},{"full_name":"Paltiel, Yossi","last_name":"Paltiel","first_name":"Yossi"},{"full_name":"Refaely-Abramson, Sivan","last_name":"Refaely-Abramson","first_name":"Sivan"},{"full_name":"Tal, Oren","last_name":"Tal","first_name":"Oren"},{"first_name":"Jos","full_name":"Thijssen, Jos","last_name":"Thijssen"},{"first_name":"Michael","full_name":"Thoss, Michael","last_name":"Thoss"},{"first_name":"Jan M.","full_name":"Van Ruitenbeek, Jan M.","last_name":"Van Ruitenbeek"},{"last_name":"Venkataraman","full_name":"Venkataraman, Latha","first_name":"Latha"},{"first_name":"David H.","last_name":"Waldeck","full_name":"Waldeck, David H."},{"first_name":"Binghai","last_name":"Yan","full_name":"Yan, Binghai"},{"first_name":"Leeor","full_name":"Kronik, Leeor","last_name":"Kronik"}],"year":"2022","oa_version":"Preprint","date_updated":"2026-04-02T12:45:15Z","article_number":"2106629","department":[{"_id":"MiLe"}],"main_file_link":[{"url":"https://arxiv.org/abs/2108.09998","open_access":"1"}],"month":"04","isi":1,"issue":"13","external_id":{"isi":["000753795900001"],"pmid":["35064943"],"arxiv":["2108.09998"]},"article_type":"review","_id":"10771","publisher":"Wiley","date_created":"2022-02-20T23:01:33Z","citation":{"ama":"Evers F, Aharony A, Bar-Gill N, et al. Theory of chirality induced spin selectivity: Progress and challenges. <i>Advanced Materials</i>. 2022;34(13). doi:<a href=\"https://doi.org/10.1002/adma.202106629\">10.1002/adma.202106629</a>","mla":"Evers, Ferdinand, et al. “Theory of Chirality Induced Spin Selectivity: Progress and Challenges.” <i>Advanced Materials</i>, vol. 34, no. 13, 2106629, Wiley, 2022, doi:<a href=\"https://doi.org/10.1002/adma.202106629\">10.1002/adma.202106629</a>.","ista":"Evers F, Aharony A, Bar-Gill N, Entin-Wohlman O, Hedegård P, Hod O, Jelinek P, Kamieniarz G, Lemeshko M, Michaeli K, Mujica V, Naaman R, Paltiel Y, Refaely-Abramson S, Tal O, Thijssen J, Thoss M, Van Ruitenbeek JM, Venkataraman L, Waldeck DH, Yan B, Kronik L. 2022. Theory of chirality induced spin selectivity: Progress and challenges. Advanced Materials. 34(13), 2106629.","short":"F. Evers, A. Aharony, N. Bar-Gill, O. Entin-Wohlman, P. Hedegård, O. Hod, P. Jelinek, G. Kamieniarz, M. Lemeshko, K. Michaeli, V. Mujica, R. Naaman, Y. Paltiel, S. Refaely-Abramson, O. Tal, J. Thijssen, M. Thoss, J.M. Van Ruitenbeek, L. Venkataraman, D.H. Waldeck, B. Yan, L. Kronik, Advanced Materials 34 (2022).","apa":"Evers, F., Aharony, A., Bar-Gill, N., Entin-Wohlman, O., Hedegård, P., Hod, O., … Kronik, L. (2022). Theory of chirality induced spin selectivity: Progress and challenges. <i>Advanced Materials</i>. Wiley. <a href=\"https://doi.org/10.1002/adma.202106629\">https://doi.org/10.1002/adma.202106629</a>","ieee":"F. Evers <i>et al.</i>, “Theory of chirality induced spin selectivity: Progress and challenges,” <i>Advanced Materials</i>, vol. 34, no. 13. Wiley, 2022.","chicago":"Evers, Ferdinand, Amnon Aharony, Nir Bar-Gill, Ora Entin-Wohlman, Per Hedegård, Oded Hod, Pavel Jelinek, et al. “Theory of Chirality Induced Spin Selectivity: Progress and Challenges.” <i>Advanced Materials</i>. Wiley, 2022. <a href=\"https://doi.org/10.1002/adma.202106629\">https://doi.org/10.1002/adma.202106629</a>."},"article_processing_charge":"No","volume":34,"status":"public","arxiv":1,"pmid":1,"title":"Theory of chirality induced spin selectivity: Progress and challenges","intvolume":"        34","oa":1},{"title":"Mirror symmetry for the Tate curve via tropical and log corals","intvolume":"       105","oa":1,"file_date_updated":"2022-02-21T11:22:58Z","status":"public","arxiv":1,"date_created":"2022-02-20T23:01:33Z","citation":{"short":"N.H. Arguez, Journal of the London Mathematical Society 105 (2022) 343–411.","apa":"Arguez, N. H. (2022). Mirror symmetry for the Tate curve via tropical and log corals. <i>Journal of the London Mathematical Society</i>. London Mathematical Society. <a href=\"https://doi.org/10.1112/jlms.12515\">https://doi.org/10.1112/jlms.12515</a>","mla":"Arguez, Nuroemuer Huelya. “Mirror Symmetry for the Tate Curve via Tropical and Log Corals.” <i>Journal of the London Mathematical Society</i>, vol. 105, no. 1, London Mathematical Society, 2022, pp. 343–411, doi:<a href=\"https://doi.org/10.1112/jlms.12515\">10.1112/jlms.12515</a>.","ama":"Arguez NH. Mirror symmetry for the Tate curve via tropical and log corals. <i>Journal of the London Mathematical Society</i>. 2022;105(1):343-411. doi:<a href=\"https://doi.org/10.1112/jlms.12515\">10.1112/jlms.12515</a>","ista":"Arguez NH. 2022. Mirror symmetry for the Tate curve via tropical and log corals. Journal of the London Mathematical Society. 105(1), 343–411.","chicago":"Arguez, Nuroemuer Huelya. “Mirror Symmetry for the Tate Curve via Tropical and Log Corals.” <i>Journal of the London Mathematical Society</i>. London Mathematical Society, 2022. <a href=\"https://doi.org/10.1112/jlms.12515\">https://doi.org/10.1112/jlms.12515</a>.","ieee":"N. H. Arguez, “Mirror symmetry for the Tate curve via tropical and log corals,” <i>Journal of the London Mathematical Society</i>, vol. 105, no. 1. London Mathematical Society, pp. 343–411, 2022."},"article_processing_charge":"Yes (via OA deal)","volume":105,"publisher":"London Mathematical Society","article_type":"original","_id":"10772","external_id":{"arxiv":["1712.10260"],"isi":["000751600600001"]},"has_accepted_license":"1","issue":"1","month":"02","isi":1,"department":[{"_id":"TaHa"}],"date_updated":"2024-10-09T21:01:37Z","ddc":["510"],"oa_version":"Published Version","year":"2022","acknowledgement":"This paper is based on my PhD thesis, which would not be possible without the support of my advisor Bernd Siebert. I also thank Dan Abramovich, Mohammed Abouzaid, Mark Gross, Tom Coates and Dimitri Zvonkine for many useful conversations. Finally, I thank the anonymous referees for their many insightful comments and valuable suggestions which have resulted in major improvements to this article. This project has received funding from the EuropeanResearch Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement Number: 682603), and from Fondation Mathématique Jacques Hadamard. ","author":[{"first_name":"Nuroemuer Huelya","full_name":"Arguez, Nuroemuer Huelya","id":"3c26b22e-c843-11eb-aa56-d38ffa0bdd08","last_name":"Arguez"}],"publication_identifier":{"issn":["0024-6107"],"eissn":["1469-7750"]},"fulldoi":"https://doi.org/10.1112/jlms.12515","corr_author":"1","abstract":[{"lang":"eng","text":"We introduce tropical corals, balanced trees in a half-space, and show that they correspond to holomorphic polygons capturing the product rule in Lagrangian Floer theory for the elliptic curve. We then prove a correspondence theorem equating counts of tropical corals to punctured log Gromov–Witten invariants of the Tate curve. This implies that the homogeneous coordinate ring of the mirror to the Tate curve is isomorphic to the degree-zero part of symplectic cohomology, confirming a prediction of homological mirror symmetry."}],"day":"05","page":"343-411","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","file":[{"date_updated":"2022-02-21T11:22:58Z","date_created":"2022-02-21T11:22:58Z","checksum":"8bd0fd9694be894a191857ddf27678f0","access_level":"open_access","file_id":"10783","relation":"main_file","file_name":"2022_JournLondonMathSociety_Arguez.pdf","file_size":936873,"content_type":"application/pdf","success":1,"creator":"dernst"}],"date_published":"2022-02-05T00:00:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1112/jlms.12515","scopus_import":"1","quality_controlled":"1","type":"journal_article","publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"language":[{"iso":"eng"}],"publication":"Journal of the London Mathematical Society"},{"oa":1,"title":"Continuous and discrete radius functions on Voronoi tessellations and Delaunay mosaics","intvolume":"        67","status":"public","file_date_updated":"2022-08-02T06:07:55Z","publisher":"Springer Nature","citation":{"ieee":"R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, and M. Saghafian, “Continuous and discrete radius functions on Voronoi tessellations and Delaunay mosaics,” <i>Discrete and Computational Geometry</i>, vol. 67. Springer Nature, pp. 811–842, 2022.","chicago":"Biswas, Ranita, Sebastiano Cultrera di Montesano, Herbert Edelsbrunner, and Morteza Saghafian. “Continuous and Discrete Radius Functions on Voronoi Tessellations and Delaunay Mosaics.” <i>Discrete and Computational Geometry</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s00454-022-00371-2\">https://doi.org/10.1007/s00454-022-00371-2</a>.","ista":"Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. 2022. Continuous and discrete radius functions on Voronoi tessellations and Delaunay mosaics. Discrete and Computational Geometry. 67, 811–842.","mla":"Biswas, Ranita, et al. “Continuous and Discrete Radius Functions on Voronoi Tessellations and Delaunay Mosaics.” <i>Discrete and Computational Geometry</i>, vol. 67, Springer Nature, 2022, pp. 811–42, doi:<a href=\"https://doi.org/10.1007/s00454-022-00371-2\">10.1007/s00454-022-00371-2</a>.","ama":"Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. Continuous and discrete radius functions on Voronoi tessellations and Delaunay mosaics. <i>Discrete and Computational Geometry</i>. 2022;67:811-842. doi:<a href=\"https://doi.org/10.1007/s00454-022-00371-2\">10.1007/s00454-022-00371-2</a>","apa":"Biswas, R., Cultrera di Montesano, S., Edelsbrunner, H., &#38; Saghafian, M. (2022). Continuous and discrete radius functions on Voronoi tessellations and Delaunay mosaics. <i>Discrete and Computational Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00454-022-00371-2\">https://doi.org/10.1007/s00454-022-00371-2</a>","short":"R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, M. Saghafian, Discrete and Computational Geometry 67 (2022) 811–842."},"article_processing_charge":"Yes (via OA deal)","date_created":"2022-02-20T23:01:34Z","volume":67,"external_id":{"isi":["000752175300002"]},"_id":"10773","article_type":"original","has_accepted_license":"1","department":[{"_id":"HeEd"}],"isi":1,"month":"04","ddc":["510"],"date_updated":"2024-10-09T21:01:38Z","acknowledgement":"Open access funding provided by the Institute of Science and Technology (IST Austria).","author":[{"first_name":"Ranita","orcid":"0000-0002-5372-7890","full_name":"Biswas, Ranita","id":"3C2B033E-F248-11E8-B48F-1D18A9856A87","last_name":"Biswas"},{"orcid":"0000-0001-6249-0832","first_name":"Sebastiano","last_name":"Cultrera Di Montesano","id":"34D2A09C-F248-11E8-B48F-1D18A9856A87","full_name":"Cultrera Di Montesano, Sebastiano"},{"first_name":"Herbert","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Saghafian, Morteza","last_name":"Saghafian","first_name":"Morteza"}],"year":"2022","oa_version":"Published Version","publication_identifier":{"issn":["0179-5376"],"eissn":["1432-0444"]},"corr_author":"1","fulldoi":"https://doi.org/10.1007/s00454-022-00371-2","day":"01","abstract":[{"lang":"eng","text":"The Voronoi tessellation in Rd is defined by locally minimizing the power distance to given weighted points. Symmetrically, the Delaunay mosaic can be defined by locally maximizing the negative power distance to other such points. We prove that the average of the two piecewise quadratic functions is piecewise linear, and that all three functions have the same critical points and values. Discretizing the two piecewise quadratic functions, we get the alpha shapes as sublevel sets of the discrete function on the Delaunay mosaic, and analogous shapes as superlevel sets of the discrete function on the Voronoi tessellation. For the same non-critical value, the corresponding shapes are disjoint, separated by a narrow channel that contains no critical points but the entire level set of the piecewise linear function."}],"date_published":"2022-04-01T00:00:00Z","file":[{"file_size":2518111,"content_type":"application/pdf","relation":"main_file","file_name":"2022_DiscreteCompGeometry_Biswas.pdf","creator":"dernst","success":1,"date_updated":"2022-08-02T06:07:55Z","date_created":"2022-08-02T06:07:55Z","access_level":"open_access","file_id":"11718","checksum":"9383d3b70561bacee905e335dc922680"}],"page":"811-842","scopus_import":"1","doi":"10.1007/s00454-022-00371-2","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","type":"journal_article","quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"publication":"Discrete and Computational Geometry"},{"scopus_import":"1","doi":"10.1007/978-3-030-94583-1_1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_status":"published","quality_controlled":"1","type":"conference","language":[{"iso":"eng"}],"publication":"Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)","publication_identifier":{"eisbn":["9783030945831"],"isbn":["9783030945824"],"eissn":["1611-3349"],"issn":["0302-9743"]},"project":[{"name":"Formal methods for the design and analysis of complex systems","grant_number":"Z211","call_identifier":"FWF","_id":"25F42A32-B435-11E9-9278-68D0E5697425"}],"fulldoi":"https://doi.org/10.1007/978-3-030-94583-1_1","conference":{"start_date":"2022-01-16","name":"VMCAI: Verifcation, Model Checking, and Abstract Interpretation","end_date":"2022-01-18","location":"Philadelphia, PA, United States"},"day":"14","abstract":[{"text":"We study the problem of specifying sequential information-flow properties of systems. Information-flow properties are hyperproperties, as they compare different traces of a system. Sequential information-flow properties can express changes, over time, in the information-flow constraints. For example, information-flow constraints during an initialization phase of a system may be different from information-flow constraints that are required during the operation phase. We formalize several variants of interpreting sequential information-flow constraints, which arise from different assumptions about what can be observed of the system. For this purpose, we introduce a first-order logic, called Hypertrace Logic, with both trace and time quantifiers for specifying linear-time hyperproperties. We prove that HyperLTL, which corresponds to a fragment of Hypertrace Logic with restricted quantifier prefixes, cannot specify the majority of the studied variants of sequential information flow, including all variants in which the transition between sequential phases (such as initialization and operation) happens asynchronously. Our results rely on new equivalences between sets of traces that cannot be distinguished by certain classes of formulas from Hypertrace Logic. This presents a new approach to proving inexpressiveness results for HyperLTL.","lang":"eng"}],"date_published":"2022-01-14T00:00:00Z","page":"1-19","alternative_title":["LNCS"],"department":[{"_id":"ToHe"}],"isi":1,"main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2105.02013"}],"month":"01","date_updated":"2026-04-16T09:13:43Z","acknowledgement":"This work was funded in part by the Wittgenstein Award Z211-N23 of the Austrian Science Fund (FWF) and by the FWF project W1255-N23.","author":[{"last_name":"Bartocci","full_name":"Bartocci, Ezio","first_name":"Ezio"},{"id":"40960E6E-F248-11E8-B48F-1D18A9856A87","last_name":"Ferrere","full_name":"Ferrere, Thomas","first_name":"Thomas","orcid":"0000-0001-5199-3143"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","full_name":"Henzinger, Thomas A","orcid":"0000-0002-2985-7724","first_name":"Thomas A"},{"first_name":"Dejan","last_name":"Nickovic","id":"41BCEE5C-F248-11E8-B48F-1D18A9856A87","full_name":"Nickovic, Dejan"},{"full_name":"Da Costa, Ana Oliveira","last_name":"Da Costa","first_name":"Ana Oliveira"}],"year":"2022","oa_version":"Preprint","oa":1,"intvolume":"     13182","title":"Flavors of sequential information flow","arxiv":1,"status":"public","publisher":"Springer Nature","citation":{"apa":"Bartocci, E., Ferrere, T., Henzinger, T. A., Nickovic, D., &#38; Da Costa, A. O. (2022). Flavors of sequential information flow. In <i>Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)</i> (Vol. 13182, pp. 1–19). Philadelphia, PA, United States: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-94583-1_1\">https://doi.org/10.1007/978-3-030-94583-1_1</a>","short":"E. Bartocci, T. Ferrere, T.A. Henzinger, D. Nickovic, A.O. Da Costa, in:, Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2022, pp. 1–19.","ista":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. 2022. Flavors of sequential information flow. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). VMCAI: Verifcation, Model Checking, and Abstract Interpretation, LNCS, vol. 13182, 1–19.","ama":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. Flavors of sequential information flow. In: <i>Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)</i>. Vol 13182. Springer Nature; 2022:1-19. doi:<a href=\"https://doi.org/10.1007/978-3-030-94583-1_1\">10.1007/978-3-030-94583-1_1</a>","mla":"Bartocci, Ezio, et al. “Flavors of Sequential Information Flow.” <i>Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)</i>, vol. 13182, Springer Nature, 2022, pp. 1–19, doi:<a href=\"https://doi.org/10.1007/978-3-030-94583-1_1\">10.1007/978-3-030-94583-1_1</a>.","chicago":"Bartocci, Ezio, Thomas Ferrere, Thomas A Henzinger, Dejan Nickovic, and Ana Oliveira Da Costa. “Flavors of Sequential Information Flow.” In <i>Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)</i>, 13182:1–19. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/978-3-030-94583-1_1\">https://doi.org/10.1007/978-3-030-94583-1_1</a>.","ieee":"E. Bartocci, T. Ferrere, T. A. Henzinger, D. Nickovic, and A. O. Da Costa, “Flavors of sequential information flow,” in <i>Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)</i>, Philadelphia, PA, United States, 2022, vol. 13182, pp. 1–19."},"article_processing_charge":"No","volume":13182,"date_created":"2022-02-20T23:01:34Z","external_id":{"arxiv":["2105.02013"],"isi":["001059208500001"]},"_id":"10774"},{"publisher":"IEEE","date_created":"2022-02-20T23:01:34Z","volume":68,"article_processing_charge":"No","citation":{"ista":"Ferber A, Kwan MA, Sauermann L. 2022. List-decodability with large radius for Reed-Solomon codes. IEEE Transactions on Information Theory. 68(6), 3823–3828.","mla":"Ferber, Asaf, et al. “List-Decodability with Large Radius for Reed-Solomon Codes.” <i>IEEE Transactions on Information Theory</i>, vol. 68, no. 6, IEEE, 2022, pp. 3823–28, doi:<a href=\"https://doi.org/10.1109/TIT.2022.3148779\">10.1109/TIT.2022.3148779</a>.","ama":"Ferber A, Kwan MA, Sauermann L. List-decodability with large radius for Reed-Solomon codes. <i>IEEE Transactions on Information Theory</i>. 2022;68(6):3823-3828. doi:<a href=\"https://doi.org/10.1109/TIT.2022.3148779\">10.1109/TIT.2022.3148779</a>","apa":"Ferber, A., Kwan, M. A., &#38; Sauermann, L. (2022). List-decodability with large radius for Reed-Solomon codes. <i>IEEE Transactions on Information Theory</i>. IEEE. <a href=\"https://doi.org/10.1109/TIT.2022.3148779\">https://doi.org/10.1109/TIT.2022.3148779</a>","short":"A. Ferber, M.A. Kwan, L. Sauermann, IEEE Transactions on Information Theory 68 (2022) 3823–3828.","ieee":"A. Ferber, M. A. Kwan, and L. Sauermann, “List-decodability with large radius for Reed-Solomon codes,” <i>IEEE Transactions on Information Theory</i>, vol. 68, no. 6. IEEE, pp. 3823–3828, 2022.","chicago":"Ferber, Asaf, Matthew Alan Kwan, and Lisa Sauermann. “List-Decodability with Large Radius for Reed-Solomon Codes.” <i>IEEE Transactions on Information Theory</i>. IEEE, 2022. <a href=\"https://doi.org/10.1109/TIT.2022.3148779\">https://doi.org/10.1109/TIT.2022.3148779</a>."},"external_id":{"arxiv":["2012.10584"],"isi":["000799622500022"]},"article_type":"original","_id":"10775","intvolume":"        68","title":"List-decodability with large radius for Reed-Solomon codes","oa":1,"status":"public","arxiv":1,"date_updated":"2025-07-10T11:50:08Z","author":[{"last_name":"Ferber","full_name":"Ferber, Asaf","first_name":"Asaf"},{"first_name":"Matthew Alan","orcid":"0000-0002-4003-7567","id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","last_name":"Kwan","full_name":"Kwan, Matthew Alan"},{"first_name":"Lisa","last_name":"Sauermann","full_name":"Sauermann, Lisa"}],"acknowledgement":"Research supported by NSF Award DMS-1953990.","year":"2022","oa_version":"Preprint","issue":"6","department":[{"_id":"MaKw"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2012.10584"}],"month":"06","isi":1,"day":"01","abstract":[{"text":"List-decodability of Reed–Solomon codes has received a lot of attention, but the best-possible dependence between the parameters is still not well-understood. In this work, we focus on the case where the list-decoding radius is of the form r = 1-ε for ε tending to zero. Our main result states that there exist Reed–Solomon codes with rate Ω(ε) which are (1 - ε, O(1/ε))-list-decodable, meaning that any Hamming ball of radius 1-ε contains at most O(1/ε) codewords. This trade-off between rate and list-decoding radius is best-possible for any code with list size less than exponential in the block length. By achieving this trade-off between rate and list-decoding radius we improve a recent result of Guo, Li, Shangguan, Tamo, and Wootters, and resolve the main motivating question of their work. Moreover, while their result requires the field to be exponentially large in the block length, we only need the field size to be polynomially large (and in fact, almost-linear suffices). We deduce our main result from a more general theorem, in which we prove good list-decodability properties of random puncturings of any given code with very large distance.","lang":"eng"}],"date_published":"2022-06-01T00:00:00Z","page":"3823-3828","publication_identifier":{"eissn":["1557-9654"],"issn":["0018-9448"]},"corr_author":"1","fulldoi":"https://doi.org/10.1109/TIT.2022.3148779","related_material":{"record":[{"status":"public","id":"11145","relation":"earlier_version"}]},"language":[{"iso":"eng"}],"publication":"IEEE Transactions on Information Theory","doi":"10.1109/TIT.2022.3148779","scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","type":"journal_article","quality_controlled":"1","publication_status":"published"},{"type":"journal_article","quality_controlled":"1","publication_status":"published","doi":"10.1007/s00454-021-00364-7","scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication":"Discrete and Computational Geometry","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1007/s00454-021-00364-7","publication_identifier":{"issn":["0179-5376"],"eissn":["1432-0444"]},"date_published":"2022-12-01T00:00:00Z","page":"1133-1154","day":"01","abstract":[{"text":"Let K be a convex body in Rn (i.e., a compact convex set with nonempty interior). Given a point p in the interior of K, a hyperplane h passing through p is called barycentric if p is the barycenter of K∩h. In 1961, Grünbaum raised the question whether, for every K, there exists an interior point p through which there are at least n+1 distinct barycentric hyperplanes. Two years later, this was seemingly resolved affirmatively by showing that this is the case if p=p0 is the point of maximal depth in K. However, while working on a related question, we noticed that one of the auxiliary claims in the proof is incorrect. Here, we provide a counterexample; this re-opens Grünbaum’s question. It follows from known results that for n≥2, there are always at least three distinct barycentric cuts through the point p0∈K of maximal depth. Using tools related to Morse theory we are able to improve this bound: four distinct barycentric cuts through p0 are guaranteed if n≥3.","lang":"eng"}],"department":[{"_id":"UlWa"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2003.13536"}],"month":"12","isi":1,"acknowledgement":"The work by Zuzana Patáková has been partially supported by Charles University Research Center Program No. UNCE/SCI/022, and part of it was done during her research stay at IST Austria. The work by Martin Tancer is supported by the GAČR Grant 19-04113Y and by the Charles University Projects PRIMUS/17/SCI/3 and UNCE/SCI/004.","author":[{"orcid":"0000-0002-3975-1683","first_name":"Zuzana","last_name":"Patakova","id":"48B57058-F248-11E8-B48F-1D18A9856A87","full_name":"Patakova, Zuzana"},{"first_name":"Martin","last_name":"Tancer","full_name":"Tancer, Martin"},{"first_name":"Uli","orcid":"0000-0002-1494-0568","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","full_name":"Wagner, Uli"}],"oa_version":"Preprint","year":"2022","date_updated":"2023-08-02T14:38:58Z","status":"public","arxiv":1,"title":"Barycentric cuts through a convex body","intvolume":"        68","oa":1,"external_id":{"isi":["000750681500001"],"arxiv":["2003.13536"]},"article_type":"original","_id":"10776","publisher":"Springer Nature","article_processing_charge":"No","date_created":"2022-02-20T23:01:35Z","citation":{"mla":"Patakova, Zuzana, et al. “Barycentric Cuts through a Convex Body.” <i>Discrete and Computational Geometry</i>, vol. 68, Springer Nature, 2022, pp. 1133–54, doi:<a href=\"https://doi.org/10.1007/s00454-021-00364-7\">10.1007/s00454-021-00364-7</a>.","ista":"Patakova Z, Tancer M, Wagner U. 2022. Barycentric cuts through a convex body. Discrete and Computational Geometry. 68, 1133–1154.","ama":"Patakova Z, Tancer M, Wagner U. Barycentric cuts through a convex body. <i>Discrete and Computational Geometry</i>. 2022;68:1133-1154. doi:<a href=\"https://doi.org/10.1007/s00454-021-00364-7\">10.1007/s00454-021-00364-7</a>","apa":"Patakova, Z., Tancer, M., &#38; Wagner, U. (2022). Barycentric cuts through a convex body. <i>Discrete and Computational Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00454-021-00364-7\">https://doi.org/10.1007/s00454-021-00364-7</a>","short":"Z. Patakova, M. Tancer, U. Wagner, Discrete and Computational Geometry 68 (2022) 1133–1154.","ieee":"Z. Patakova, M. Tancer, and U. Wagner, “Barycentric cuts through a convex body,” <i>Discrete and Computational Geometry</i>, vol. 68. Springer Nature, pp. 1133–1154, 2022.","chicago":"Patakova, Zuzana, Martin Tancer, and Uli Wagner. “Barycentric Cuts through a Convex Body.” <i>Discrete and Computational Geometry</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s00454-021-00364-7\">https://doi.org/10.1007/s00454-021-00364-7</a>."},"volume":68},{"issue":"1848","has_accepted_license":"1","department":[{"_id":"GradSch"},{"_id":"NiBa"}],"month":"04","isi":1,"ddc":["570"],"date_updated":"2026-04-07T12:54:28Z","author":[{"first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Olusanya, Oluwafunmilola O","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","last_name":"Olusanya","first_name":"Oluwafunmilola O","orcid":"0000-0003-1971-8314"}],"acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) [FWF P-32896B].","oa_version":"Published Version","year":"2022","title":"The response of a metapopulation to a changing environment","intvolume":"       377","oa":1,"status":"public","pmid":1,"file_date_updated":"2022-08-02T06:14:32Z","publisher":"The Royal Society","article_processing_charge":"No","citation":{"ieee":"N. H. Barton and O. O. Olusanya, “The response of a metapopulation to a changing environment,” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>, vol. 377, no. 1848. The Royal Society, 2022.","chicago":"Barton, Nicholas H, and Oluwafunmilola O Olusanya. “The Response of a Metapopulation to a Changing Environment.” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. The Royal Society, 2022. <a href=\"https://doi.org/10.1098/rstb.2021.0009\">https://doi.org/10.1098/rstb.2021.0009</a>.","mla":"Barton, Nicholas H., and Oluwafunmilola O. Olusanya. “The Response of a Metapopulation to a Changing Environment.” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>, vol. 377, no. 1848, The Royal Society, 2022, doi:<a href=\"https://doi.org/10.1098/rstb.2021.0009\">10.1098/rstb.2021.0009</a>.","ama":"Barton NH, Olusanya OO. The response of a metapopulation to a changing environment. <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. 2022;377(1848). doi:<a href=\"https://doi.org/10.1098/rstb.2021.0009\">10.1098/rstb.2021.0009</a>","ista":"Barton NH, Olusanya OO. 2022. The response of a metapopulation to a changing environment. Philosophical Transactions of the Royal Society B: Biological Sciences. 377(1848).","apa":"Barton, N. H., &#38; Olusanya, O. O. (2022). The response of a metapopulation to a changing environment. <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2021.0009\">https://doi.org/10.1098/rstb.2021.0009</a>","short":"N.H. Barton, O.O. Olusanya, Philosophical Transactions of the Royal Society B: Biological Sciences 377 (2022)."},"volume":377,"date_created":"2022-02-21T16:08:10Z","external_id":{"isi":["000758140300001"],"pmid":["35184588"]},"article_type":"original","_id":"10787","doi":"10.1098/rstb.2021.0009","scopus_import":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","type":"journal_article","quality_controlled":"1","publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"related_material":{"record":[{"relation":"dissertation_contains","id":"14711","status":"public"}]},"publication":"Philosophical Transactions of the Royal Society B: Biological Sciences","publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"project":[{"_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8","grant_number":"P32896","name":"Causes and consequences of population fragmentation"}],"corr_author":"1","fulldoi":"https://doi.org/10.1098/rstb.2021.0009","day":"11","abstract":[{"text":"A species distributed across diverse environments may adapt to local conditions. We ask how quickly such a species changes its range in response to changed conditions. Szép et al. (Szép E, Sachdeva H, Barton NH. 2021 Polygenic local adaptation in metapopulations: a stochastic eco-evolutionary model. Evolution75, 1030–1045 (doi:10.1111/evo.14210)) used the infinite island model to find the stationary distribution of allele frequencies and deme sizes. We extend this to find how a metapopulation responds to changes in carrying capacity, selection strength, or migration rate when deme sizes are fixed. We further develop a ‘fixed-state’ approximation. Under this approximation, polymorphism is only possible for a narrow range of habitat proportions when selection is weak compared to drift, but for a much wider range otherwise. When rates of selection or migration relative to drift change in a single deme of the metapopulation, the population takes a time of order m−1 to reach the new equilibrium. However, even with many loci, there can be substantial fluctuations in net adaptation, because at each locus, alleles randomly get lost or fixed. Thus, in a finite metapopulation, variation may gradually be lost by chance, even if it would persist in an infinite metapopulation. When conditions change across the whole metapopulation, there can be rapid change, which is predicted well by the fixed-state approximation. This work helps towards an understanding of how metapopulations extend their range across diverse environments.\r\nThis article is part of the theme issue ‘Species’ ranges in the face of changing environments (Part II)’.","lang":"eng"}],"date_published":"2022-04-11T00:00:00Z","file":[{"creator":"dernst","success":1,"content_type":"application/pdf","file_size":1349672,"file_name":"2022_PhilosophicalTransactionsRSB_Barton.pdf","relation":"main_file","file_id":"11719","access_level":"open_access","checksum":"3b0243738f01bf3c07e0d7e8dc64f71d","date_created":"2022-08-02T06:14:32Z","date_updated":"2022-08-02T06:14:32Z"}]},{"publication":"Oxford Open Neuroscience","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"12726"},{"id":"14530","relation":"dissertation_contains","status":"public"}]},"language":[{"iso":"eng"}],"publication_status":"published","type":"journal_article","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1093/oons/kvac009","file":[{"date_created":"2023-08-16T08:00:30Z","date_updated":"2023-08-16T08:00:30Z","file_id":"14061","access_level":"open_access","checksum":"822e76e056c07099d1fb27d1ece5941b","content_type":"application/pdf","file_size":4846551,"file_name":"2023_OxfordOpenNeuroscience_Hansen.pdf","relation":"main_file","creator":"dernst","success":1}],"date_published":"2022-07-07T00:00:00Z","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"PreCl"},{"_id":"Bio"}],"abstract":[{"lang":"eng","text":"The mammalian neocortex is composed of diverse neuronal and glial cell classes that broadly arrange in six distinct laminae. Cortical layers emerge during development and defects in the developmental programs that orchestrate cortical lamination are associated with neurodevelopmental diseases. The developmental principle of cortical layer formation depends on concerted radial projection neuron migration, from their birthplace to their final target position. Radial migration occurs in defined sequential steps, regulated by a large array of signaling pathways. However, based on genetic loss-of-function experiments, most studies have thus far focused on the role of cell-autonomous gene function. Yet, cortical neuron migration in situ is a complex process and migrating neurons traverse along diverse cellular compartments and environments. The role of tissue-wide properties and genetic state in radial neuron migration is however not clear. Here we utilized mosaic analysis with double markers (MADM) technology to either sparsely or globally delete gene function, followed by quantitative single-cell phenotyping. The MADM-based gene ablation paradigms in combination with computational modeling demonstrated that global tissue-wide effects predominate cell-autonomous gene function albeit in a gene-specific manner. Our results thus suggest that the genetic landscape in a tissue critically affects the overall migration phenotype of individual cortical projection neurons. In a broader context, our findings imply that global tissue-wide effects represent an essential component of the underlying etiology associated with focal malformations of cortical development in particular, and neurological diseases in general."}],"day":"07","corr_author":"1","fulldoi":"https://doi.org/10.1093/oons/kvac009","ec_funded":1,"project":[{"name":"Molecular Mechanisms of Cerebral Cortex Development","grant_number":"618444","call_identifier":"FP7","_id":"25D61E48-B435-11E9-9278-68D0E5697425"},{"grant_number":"24812","name":"Molecular mechanisms of radial neuronal migration","_id":"2625A13E-B435-11E9-9278-68D0E5697425"}],"publication_identifier":{"eissn":["2753-149X"]},"oa_version":"Published Version","year":"2022","acknowledgement":"A.H.H. was a recipient of a DOC Fellowship (24812) of the Austrian Academy of Sciences. This work also received support from IST Austria institutional funds; the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007–2013) under REA grant agreement No 618444 to S.H.\r\nAPC funding was obtained by IST Austria institutional funds.\r\nWe thank A. Sommer and C. Czepe (VBCF GmbH, NGS Unit), L. Andersen, J. Sonntag and J. Renno for technical support and/or initial experiments; M. Sixt, J. Nimpf and all members of the Hippenmeyer lab for discussion. This research was supported by the Scientific Service Units of IST Austria through resources provided by the Imaging and Optics Facility, Lab Support Facility and Preclinical Facility.","author":[{"last_name":"Hansen","id":"38853E16-F248-11E8-B48F-1D18A9856A87","full_name":"Hansen, Andi H","first_name":"Andi H"},{"last_name":"Pauler","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","full_name":"Pauler, Florian","first_name":"Florian","orcid":"0000-0002-7462-0048"},{"full_name":"Riedl, Michael","last_name":"Riedl","id":"3BE60946-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4844-6311","first_name":"Michael"},{"first_name":"Carmen","last_name":"Streicher","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","full_name":"Streicher, Carmen"},{"first_name":"Anna-Magdalena","full_name":"Heger, Anna-Magdalena","last_name":"Heger","id":"4B76FFD2-F248-11E8-B48F-1D18A9856A87"},{"id":"2D6B7A9A-F248-11E8-B48F-1D18A9856A87","last_name":"Laukoter","full_name":"Laukoter, Susanne","orcid":"0000-0002-7903-3010","first_name":"Susanne"},{"last_name":"Sommer","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","full_name":"Sommer, Christoph M","orcid":"0000-0003-1216-9105","first_name":"Christoph M"},{"first_name":"Armel","id":"2A103192-F248-11E8-B48F-1D18A9856A87","last_name":"Nicolas","full_name":"Nicolas, Armel"},{"orcid":"0000-0003-2057-2754","first_name":"Björn","full_name":"Hof, Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","last_name":"Hof"},{"full_name":"Tsai, Li Huei","last_name":"Tsai","first_name":"Li Huei"},{"full_name":"Rülicke, Thomas","last_name":"Rülicke","first_name":"Thomas"},{"orcid":"0000-0003-2279-1061","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","full_name":"Hippenmeyer, Simon"}],"article_number":"kvac009","date_updated":"2026-04-07T13:29:13Z","ddc":["570"],"month":"07","department":[{"_id":"SiHi"},{"_id":"BjHo"},{"_id":"LifeSc"},{"_id":"EM-Fac"}],"has_accepted_license":"1","issue":"1","_id":"10791","article_type":"original","external_id":{"pmid":["38596707"]},"article_processing_charge":"No","date_created":"2022-02-25T07:52:11Z","volume":1,"citation":{"chicago":"Hansen, Andi H, Florian Pauler, Michael Riedl, Carmen Streicher, Anna-Magdalena Heger, Susanne Laukoter, Christoph M Sommer, et al. “Tissue-Wide Effects Override Cell-Intrinsic Gene Function in Radial Neuron Migration.” <i>Oxford Open Neuroscience</i>. Oxford University Press, 2022. <a href=\"https://doi.org/10.1093/oons/kvac009\">https://doi.org/10.1093/oons/kvac009</a>.","ieee":"A. H. Hansen <i>et al.</i>, “Tissue-wide effects override cell-intrinsic gene function in radial neuron migration,” <i>Oxford Open Neuroscience</i>, vol. 1, no. 1. Oxford University Press, 2022.","short":"A.H. Hansen, F. Pauler, M. Riedl, C. Streicher, A.-M. Heger, S. Laukoter, C.M. Sommer, A. Nicolas, B. Hof, L.H. Tsai, T. Rülicke, S. Hippenmeyer, Oxford Open Neuroscience 1 (2022).","apa":"Hansen, A. H., Pauler, F., Riedl, M., Streicher, C., Heger, A.-M., Laukoter, S., … Hippenmeyer, S. (2022). Tissue-wide effects override cell-intrinsic gene function in radial neuron migration. <i>Oxford Open Neuroscience</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/oons/kvac009\">https://doi.org/10.1093/oons/kvac009</a>","ista":"Hansen AH, Pauler F, Riedl M, Streicher C, Heger A-M, Laukoter S, Sommer CM, Nicolas A, Hof B, Tsai LH, Rülicke T, Hippenmeyer S. 2022. Tissue-wide effects override cell-intrinsic gene function in radial neuron migration. Oxford Open Neuroscience. 1(1), kvac009.","mla":"Hansen, Andi H., et al. “Tissue-Wide Effects Override Cell-Intrinsic Gene Function in Radial Neuron Migration.” <i>Oxford Open Neuroscience</i>, vol. 1, no. 1, kvac009, Oxford University Press, 2022, doi:<a href=\"https://doi.org/10.1093/oons/kvac009\">10.1093/oons/kvac009</a>.","ama":"Hansen AH, Pauler F, Riedl M, et al. Tissue-wide effects override cell-intrinsic gene function in radial neuron migration. <i>Oxford Open Neuroscience</i>. 2022;1(1). doi:<a href=\"https://doi.org/10.1093/oons/kvac009\">10.1093/oons/kvac009</a>"},"publisher":"Oxford University Press","pmid":1,"file_date_updated":"2023-08-16T08:00:30Z","status":"public","oa":1,"intvolume":"         1","title":"Tissue-wide effects override cell-intrinsic gene function in radial neuron migration"}]