[{"_id":"9410","has_accepted_license":"1","external_id":{"pmid":[" 33975485"],"isi":["000651501400001"]},"department":[{"_id":"NiBa"}],"year":"2021","project":[{"name":"Limits to selection in biology and in evolutionary computation","grant_number":"250152","_id":"25B07788-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"date_published":"2021-05-12T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publisher":"Royal Society of London","corr_author":"1","date_updated":"2026-04-02T14:02:44Z","scopus_import":"1","citation":{"apa":"Lagator, M., Uecker, H., &#38; Neve, P. (2021). Adaptation at different points along antibiotic concentration gradients. <i>Biology Letters</i>. Royal Society of London. <a href=\"https://doi.org/10.1098/rsbl.2020.0913\">https://doi.org/10.1098/rsbl.2020.0913</a>","short":"M. Lagator, H. Uecker, P. Neve, Biology Letters 17 (2021).","ista":"Lagator M, Uecker H, Neve P. 2021. Adaptation at different points along antibiotic concentration gradients. Biology letters. 17(5), 20200913.","ama":"Lagator M, Uecker H, Neve P. Adaptation at different points along antibiotic concentration gradients. <i>Biology letters</i>. 2021;17(5). doi:<a href=\"https://doi.org/10.1098/rsbl.2020.0913\">10.1098/rsbl.2020.0913</a>","chicago":"Lagator, Mato, Hildegard Uecker, and Paul Neve. “Adaptation at Different Points along Antibiotic Concentration Gradients.” <i>Biology Letters</i>. Royal Society of London, 2021. <a href=\"https://doi.org/10.1098/rsbl.2020.0913\">https://doi.org/10.1098/rsbl.2020.0913</a>.","ieee":"M. Lagator, H. Uecker, and P. Neve, “Adaptation at different points along antibiotic concentration gradients,” <i>Biology letters</i>, vol. 17, no. 5. Royal Society of London, 2021.","mla":"Lagator, Mato, et al. “Adaptation at Different Points along Antibiotic Concentration Gradients.” <i>Biology Letters</i>, vol. 17, no. 5, 20200913, Royal Society of London, 2021, doi:<a href=\"https://doi.org/10.1098/rsbl.2020.0913\">10.1098/rsbl.2020.0913</a>."},"oa":1,"publication_identifier":{"eissn":["1744-957X"]},"pmid":1,"doi":"10.1098/rsbl.2020.0913","author":[{"full_name":"Lagator, Mato","id":"345D25EC-F248-11E8-B48F-1D18A9856A87","first_name":"Mato","last_name":"Lagator"},{"full_name":"Uecker, Hildegard","orcid":"0000-0001-9435-2813","last_name":"Uecker","first_name":"Hildegard","id":"2DB8F68A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Neve, Paul","first_name":"Paul","last_name":"Neve"}],"article_processing_charge":"No","title":"Adaptation at different points along antibiotic concentration gradients","file_date_updated":"2021-05-25T14:09:03Z","month":"05","file":[{"access_level":"open_access","date_updated":"2021-05-25T14:09:03Z","creator":"kschuh","file_name":"2021_BiologyLetters_Lagator.pdf","content_type":"application/pdf","file_size":726759,"checksum":"9c13c1f5af7609c97c741f11d293188a","success":1,"date_created":"2021-05-25T14:09:03Z","file_id":"9425","relation":"main_file"}],"intvolume":"        17","quality_controlled":"1","status":"public","publication_status":"published","article_number":"20200913","language":[{"iso":"eng"}],"type":"journal_article","acknowledgement":"We would like to thank Martin Ackermann, Camilo Barbosa, Nick Barton, Jonathan Bollback, Sebastian Bonhoeffer, Nick Colegrave, Calin Guet, Alex Hall, Sally Otto, Tiago Paixao, Srdjan Sarikas, Hinrich Schulenburg, Marjon de Vos and Michael Whitlock for insightful support.","date_created":"2021-05-23T22:01:43Z","publication":"Biology letters","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"text":"Antibiotic concentrations vary dramatically in the body and the environment. Hence, understanding the dynamics of resistance evolution along antibiotic concentration gradients is critical for predicting and slowing the emergence and spread of resistance. While it has been shown that increasing the concentration of an antibiotic slows resistance evolution, how adaptation to one antibiotic concentration correlates with fitness at other points along the gradient has not received much attention. Here, we selected populations of Escherichia coli at several points along a concentration gradient for three different antibiotics, asking how rapidly resistance evolved and whether populations became specialized to the antibiotic concentration they were selected on. Populations selected at higher concentrations evolved resistance more slowly but exhibited equal or higher fitness across the whole gradient. Populations selected at lower concentrations evolved resistance rapidly, but overall fitness in the presence of antibiotics was lower. However, these populations readily adapted to higher concentrations upon subsequent selection. Our results indicate that resistance management strategies must account not only for the rates of resistance evolution but also for the fitness of evolved strains.","lang":"eng"}],"issue":"5","ec_funded":1,"isi":1,"oa_version":"Published Version","volume":17,"day":"12","ddc":["570"]},{"has_accepted_license":"1","_id":"8601","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2021-02-01T00:00:00Z","project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"},{"name":"Random matrices, universality and disordered quantum systems","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","call_identifier":"FP7"},{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"}],"department":[{"_id":"LaEr"}],"year":"2021","external_id":{"arxiv":["1908.00969"],"isi":["000572724600002"]},"corr_author":"1","publisher":"Springer Nature","date_updated":"2026-04-02T14:03:52Z","scopus_import":"1","oa":1,"publication_identifier":{"issn":["0178-8051"],"eissn":["1432-2064"]},"citation":{"apa":"Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2021). Edge universality for non-Hermitian random matrices. <i>Probability Theory and Related Fields</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00440-020-01003-7\">https://doi.org/10.1007/s00440-020-01003-7</a>","short":"G. Cipolloni, L. Erdös, D.J. Schröder, Probability Theory and Related Fields (2021).","ista":"Cipolloni G, Erdös L, Schröder DJ. 2021. Edge universality for non-Hermitian random matrices. Probability Theory and Related Fields.","ama":"Cipolloni G, Erdös L, Schröder DJ. Edge universality for non-Hermitian random matrices. <i>Probability Theory and Related Fields</i>. 2021. doi:<a href=\"https://doi.org/10.1007/s00440-020-01003-7\">10.1007/s00440-020-01003-7</a>","chicago":"Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Edge Universality for Non-Hermitian Random Matrices.” <i>Probability Theory and Related Fields</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s00440-020-01003-7\">https://doi.org/10.1007/s00440-020-01003-7</a>.","ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “Edge universality for non-Hermitian random matrices,” <i>Probability Theory and Related Fields</i>. Springer Nature, 2021.","mla":"Cipolloni, Giorgio, et al. “Edge Universality for Non-Hermitian Random Matrices.” <i>Probability Theory and Related Fields</i>, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1007/s00440-020-01003-7\">10.1007/s00440-020-01003-7</a>."},"doi":"10.1007/s00440-020-01003-7","title":"Edge universality for non-Hermitian random matrices","article_processing_charge":"Yes (via OA deal)","author":[{"id":"42198EFA-F248-11E8-B48F-1D18A9856A87","first_name":"Giorgio","last_name":"Cipolloni","orcid":"0000-0002-4901-7992","full_name":"Cipolloni, Giorgio"},{"full_name":"Erdös, László","orcid":"0000-0001-5366-9603","first_name":"László","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-2904-1856","full_name":"Schröder, Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87","last_name":"Schröder","first_name":"Dominik J"}],"arxiv":1,"month":"02","file_date_updated":"2020-10-05T14:53:40Z","file":[{"access_level":"open_access","creator":"dernst","date_updated":"2020-10-05T14:53:40Z","file_name":"2020_ProbTheory_Cipolloni.pdf","content_type":"application/pdf","date_created":"2020-10-05T14:53:40Z","success":1,"file_size":497032,"checksum":"611ae28d6055e1e298d53a57beb05ef4","file_id":"8612","relation":"main_file"}],"publication_status":"published","status":"public","quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","publication":"Probability Theory and Related Fields","date_created":"2020-10-04T22:01:37Z","abstract":[{"lang":"eng","text":"We consider large non-Hermitian real or complex random matrices X with independent, identically distributed centred entries. We prove that their local eigenvalue statistics near the spectral edge, the unit circle, coincide with those of the Ginibre ensemble, i.e. when the matrix elements of X are Gaussian. This result is the non-Hermitian counterpart of the universality of the Tracy–Widom distribution at the spectral edges of the Wigner ensemble."}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","day":"01","ddc":["510"],"oa_version":"Published Version","isi":1,"ec_funded":1},{"article_number":"e28","publication_status":"published","status":"public","quality_controlled":"1","acknowledgement":"The first author gratefully acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie Grant Agreement No. 754411. The third author was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 694227).","language":[{"iso":"eng"}],"type":"journal_article","month":"03","file_date_updated":"2021-04-12T07:15:58Z","intvolume":"         9","file":[{"creator":"dernst","date_updated":"2021-04-12T07:15:58Z","file_name":"2021_ForumMath_Bossmann.pdf","access_level":"open_access","date_created":"2021-04-12T07:15:58Z","success":1,"file_size":883851,"checksum":"17a3e6786d1e930cf0c14a880a6d7e92","file_id":"9319","relation":"main_file","content_type":"application/pdf"}],"abstract":[{"lang":"eng","text":"We consider a system of N bosons in the mean-field scaling regime for a class of interactions including the repulsive Coulomb potential. We derive an asymptotic expansion of the low-energy eigenstates and the corresponding energies, which provides corrections to Bogoliubov theory to any order in 1/N."}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","day":"26","ddc":["510"],"oa_version":"Published Version","volume":9,"isi":1,"ec_funded":1,"date_created":"2021-04-11T22:01:15Z","publication":"Forum of Mathematics, Sigma","publisher":"Cambridge University Press","date_updated":"2026-04-02T14:02:29Z","has_accepted_license":"1","_id":"9318","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2021-03-26T00:00:00Z","department":[{"_id":"RoSe"}],"external_id":{"isi":["000634006900001"]},"project":[{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"name":"Analysis of quantum many-body systems","grant_number":"694227","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"year":"2021","doi":"10.1017/fms.2021.22","title":"Asymptotic expansion of low-energy excitations for weakly interacting bosons","author":[{"id":"A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425","last_name":"Bossmann","first_name":"Lea","orcid":"0000-0002-6854-1343","full_name":"Bossmann, Lea"},{"full_name":"Petrat, Sören P","orcid":"0000-0002-9166-5889","first_name":"Sören P","last_name":"Petrat","id":"40AC02DC-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","first_name":"Robert"}],"article_processing_charge":"Yes (via OA deal)","scopus_import":"1","oa":1,"publication_identifier":{"eissn":["2050-5094"]},"citation":{"ama":"Bossmann L, Petrat SP, Seiringer R. Asymptotic expansion of low-energy excitations for weakly interacting bosons. <i>Forum of Mathematics, Sigma</i>. 2021;9. doi:<a href=\"https://doi.org/10.1017/fms.2021.22\">10.1017/fms.2021.22</a>","ista":"Bossmann L, Petrat SP, Seiringer R. 2021. Asymptotic expansion of low-energy excitations for weakly interacting bosons. Forum of Mathematics, Sigma. 9, e28.","short":"L. Bossmann, S.P. Petrat, R. Seiringer, Forum of Mathematics, Sigma 9 (2021).","apa":"Bossmann, L., Petrat, S. P., &#38; Seiringer, R. (2021). Asymptotic expansion of low-energy excitations for weakly interacting bosons. <i>Forum of Mathematics, Sigma</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/fms.2021.22\">https://doi.org/10.1017/fms.2021.22</a>","mla":"Bossmann, Lea, et al. “Asymptotic Expansion of Low-Energy Excitations for Weakly Interacting Bosons.” <i>Forum of Mathematics, Sigma</i>, vol. 9, e28, Cambridge University Press, 2021, doi:<a href=\"https://doi.org/10.1017/fms.2021.22\">10.1017/fms.2021.22</a>.","ieee":"L. Bossmann, S. P. Petrat, and R. Seiringer, “Asymptotic expansion of low-energy excitations for weakly interacting bosons,” <i>Forum of Mathematics, Sigma</i>, vol. 9. Cambridge University Press, 2021.","chicago":"Bossmann, Lea, Sören P Petrat, and Robert Seiringer. “Asymptotic Expansion of Low-Energy Excitations for Weakly Interacting Bosons.” <i>Forum of Mathematics, Sigma</i>. Cambridge University Press, 2021. <a href=\"https://doi.org/10.1017/fms.2021.22\">https://doi.org/10.1017/fms.2021.22</a>."}},{"publisher":"American Physical Society","date_updated":"2026-04-02T14:02:07Z","main_file_link":[{"url":"https://arxiv.org/abs/2007.14879","open_access":"1"}],"_id":"8198","date_published":"2021-06-21T00:00:00Z","department":[{"_id":"MaSe"}],"year":"2021","project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"}],"external_id":{"arxiv":["2007.14879"],"isi":["000664429700005"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.1103/PhysRevB.103.214204","arxiv":1,"article_processing_charge":"No","author":[{"full_name":"Diringer, Asaf A.","last_name":"Diringer","first_name":"Asaf A."},{"id":"1083E038-9F73-11E9-A4B5-532AE6697425","first_name":"Tobias","last_name":"Gulden","orcid":"0000-0001-6814-7541","full_name":"Gulden, Tobias"}],"title":"Impact of drive harmonics on the stability of Floquet many-body localization","scopus_import":"1","citation":{"chicago":"Diringer, Asaf A., and Tobias Gulden. “Impact of Drive Harmonics on the Stability of Floquet Many-Body Localization.” <i>Physical Review B</i>. American Physical Society, 2021. <a href=\"https://doi.org/10.1103/PhysRevB.103.214204\">https://doi.org/10.1103/PhysRevB.103.214204</a>.","ieee":"A. A. Diringer and T. Gulden, “Impact of drive harmonics on the stability of Floquet many-body localization,” <i>Physical Review B</i>, vol. 103, no. 21. American Physical Society, 2021.","mla":"Diringer, Asaf A., and Tobias Gulden. “Impact of Drive Harmonics on the Stability of Floquet Many-Body Localization.” <i>Physical Review B</i>, vol. 103, no. 21, 214204, American Physical Society, 2021, doi:<a href=\"https://doi.org/10.1103/PhysRevB.103.214204\">10.1103/PhysRevB.103.214204</a>.","short":"A.A. Diringer, T. Gulden, Physical Review B 103 (2021).","apa":"Diringer, A. A., &#38; Gulden, T. (2021). Impact of drive harmonics on the stability of Floquet many-body localization. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.103.214204\">https://doi.org/10.1103/PhysRevB.103.214204</a>","ista":"Diringer AA, Gulden T. 2021. Impact of drive harmonics on the stability of Floquet many-body localization. Physical Review B. 103(21), 214204.","ama":"Diringer AA, Gulden T. Impact of drive harmonics on the stability of Floquet many-body localization. <i>Physical Review B</i>. 2021;103(21). doi:<a href=\"https://doi.org/10.1103/PhysRevB.103.214204\">10.1103/PhysRevB.103.214204</a>"},"publication_identifier":{"issn":["2469-9950"],"eissn":["2469-9969"]},"oa":1,"quality_controlled":"1","publication_status":"published","article_number":"214204","status":"public","type":"journal_article","language":[{"iso":"eng"}],"acknowledgement":"We thank Y. Bar Lev, T. Biadse, and, particularly, E. Bairey and B. Katzir for illuminating discussions and their many insights and help. The authors thank N. Lindner for his support throughout this project. We are further grateful to M. Serbyn, A. Kamenev, A. Turner, and S. de Nicola for reading the manuscript and providing good feedback and suggestions. We acknowledge financial support from the Defense Advanced Research Projects Agency through the DRINQS program, Grant No. D18AC00025. T.G. was in part supported by an Aly Kaufman Fellowship at the Technion. T.G. acknowledges funding from the Institute of Science and Technology (IST) Austria and from the European Union’s Horizon 2020 research and innovation program under Marie SkłodowskaCurie Grant Agreement No. 754411.under the Marie Skłodowska-Curie Grant Agreement No.754411.","month":"06","intvolume":"       103","article_type":"original","issue":"21","abstract":[{"lang":"eng","text":"We investigate how the critical driving amplitude at the Floquet many-body localized (MBL) to ergodic phase transition differs between smooth and nonsmooth drives. To this end, we numerically study a disordered spin-1/2 chain which is periodically driven by a sine or square-wave drive over a wide range of driving frequencies. In both cases the critical driving amplitude increases monotonically with the frequency, and at large frequencies it is identical for the two drives. However, at low and intermediate frequencies the critical amplitude of the square-wave drive depends strongly on the frequency, while that of the sinusoidal drive is almost constant over a wide frequency range. By analyzing the density of drive-induced resonances we conclude that this difference is due to resonances induced by the higher harmonics which are present (absent) in the Fourier spectrum of the square-wave (sine) drive. Furthermore, we suggest a numerically efficient method for estimating the frequency dependence of the critical driving amplitudes for different drives which is based on calculating the density of drive-induced resonances. We conclude that delocalization occurs once the density of drive-induced resonances reaches a critical value determined only by the static system."}],"ec_funded":1,"isi":1,"day":"21","volume":103,"oa_version":"Preprint","date_created":"2020-08-04T13:03:40Z","publication":"Physical Review B"},{"citation":{"chicago":"Contreras, Ximena, Nicole Amberg, Amarbayasgalan Davaatseren, Andi H Hansen, Johanna Sonntag, Lill Andersen, Tina Bernthaler, et al. “A Genome-Wide Library of MADM Mice for Single-Cell Genetic Mosaic Analysis.” <i>Cell Reports</i>. Cell Press, 2021. <a href=\"https://doi.org/10.1016/j.celrep.2021.109274\">https://doi.org/10.1016/j.celrep.2021.109274</a>.","ieee":"X. Contreras <i>et al.</i>, “A genome-wide library of MADM mice for single-cell genetic mosaic analysis,” <i>Cell Reports</i>, vol. 35, no. 12. Cell Press, 2021.","mla":"Contreras, Ximena, et al. “A Genome-Wide Library of MADM Mice for Single-Cell Genetic Mosaic Analysis.” <i>Cell Reports</i>, vol. 35, no. 12, 109274, Cell Press, 2021, doi:<a href=\"https://doi.org/10.1016/j.celrep.2021.109274\">10.1016/j.celrep.2021.109274</a>.","short":"X. Contreras, N. Amberg, A. Davaatseren, A.H. Hansen, J. Sonntag, L. Andersen, T. Bernthaler, C. Streicher, A.-M. Heger, R.L. Johnson, L.A. Schwarz, L. Luo, T. Rülicke, S. Hippenmeyer, Cell Reports 35 (2021).","apa":"Contreras, X., Amberg, N., Davaatseren, A., Hansen, A. H., Sonntag, J., Andersen, L., … Hippenmeyer, S. (2021). A genome-wide library of MADM mice for single-cell genetic mosaic analysis. <i>Cell Reports</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.celrep.2021.109274\">https://doi.org/10.1016/j.celrep.2021.109274</a>","ista":"Contreras X, Amberg N, Davaatseren A, Hansen AH, Sonntag J, Andersen L, Bernthaler T, Streicher C, Heger A-M, Johnson RL, Schwarz LA, Luo L, Rülicke T, Hippenmeyer S. 2021. A genome-wide library of MADM mice for single-cell genetic mosaic analysis. Cell Reports. 35(12), 109274.","ama":"Contreras X, Amberg N, Davaatseren A, et al. A genome-wide library of MADM mice for single-cell genetic mosaic analysis. <i>Cell Reports</i>. 2021;35(12). doi:<a href=\"https://doi.org/10.1016/j.celrep.2021.109274\">10.1016/j.celrep.2021.109274</a>"},"publication_identifier":{"eissn":["2211-1247"]},"oa":1,"scopus_import":"1","related_material":{"link":[{"url":"https://ist.ac.at/en/news/boost-for-mouse-genetic-analysis/","description":"News on IST Homepage","relation":"press_release"}]},"article_processing_charge":"No","author":[{"full_name":"Contreras, Ximena","id":"475990FE-F248-11E8-B48F-1D18A9856A87","last_name":"Contreras","first_name":"Ximena"},{"id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","first_name":"Nicole","last_name":"Amberg","orcid":"0000-0002-3183-8207","full_name":"Amberg, Nicole"},{"full_name":"Davaatseren, Amarbayasgalan","first_name":"Amarbayasgalan","last_name":"Davaatseren","id":"70ADC922-B424-11E9-99E3-BA18E6697425"},{"last_name":"Hansen","first_name":"Andi H","id":"38853E16-F248-11E8-B48F-1D18A9856A87","full_name":"Hansen, Andi H"},{"last_name":"Sonntag","first_name":"Johanna","id":"32FE7D7C-F248-11E8-B48F-1D18A9856A87","full_name":"Sonntag, Johanna"},{"full_name":"Andersen, Lill","first_name":"Lill","last_name":"Andersen"},{"full_name":"Bernthaler, Tina","last_name":"Bernthaler","first_name":"Tina"},{"first_name":"Carmen","last_name":"Streicher","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","full_name":"Streicher, Carmen"},{"full_name":"Heger, Anna-Magdalena","last_name":"Heger","first_name":"Anna-Magdalena","id":"4B76FFD2-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Johnson, Randy L.","last_name":"Johnson","first_name":"Randy L."},{"full_name":"Schwarz, Lindsay A.","last_name":"Schwarz","first_name":"Lindsay A."},{"first_name":"Liqun","last_name":"Luo","full_name":"Luo, Liqun"},{"first_name":"Thomas","last_name":"Rülicke","full_name":"Rülicke, Thomas"},{"id":"37B36620-F248-11E8-B48F-1D18A9856A87","first_name":"Simon","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon"}],"title":"A genome-wide library of MADM mice for single-cell genetic mosaic analysis","doi":"10.1016/j.celrep.2021.109274","pmid":1,"date_published":"2021-06-22T00:00:00Z","external_id":{"isi":["000664463600016"],"pmid":["34161767"]},"project":[{"name":"Molecular mechanisms of radial neuronal migration","_id":"2625A13E-B435-11E9-9278-68D0E5697425","grant_number":"24812"},{"call_identifier":"FP7","grant_number":"618444","_id":"25D61E48-B435-11E9-9278-68D0E5697425","name":"Molecular Mechanisms of Cerebral Cortex Development"},{"name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","_id":"260018B0-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"department":[{"_id":"SiHi"},{"_id":"LoSw"},{"_id":"PreCl"}],"year":"2021","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"9603","has_accepted_license":"1","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","date_updated":"2026-04-02T14:04:28Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"PreCl"}],"publisher":"Cell Press","date_created":"2021-06-27T22:01:48Z","publication":"Cell Reports","ec_funded":1,"isi":1,"ddc":["570"],"day":"22","oa_version":"Published Version","volume":35,"tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"article_type":"original","abstract":[{"lang":"eng","text":"Mosaic analysis with double markers (MADM) offers one approach to visualize and concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM applications include the analysis of lineage, single-cell morphology and physiology, genomic imprinting phenotypes, and dissection of cell-autonomous gene functions in vivo in health and disease. Yet, MADM can only be applied to <25% of all mouse genes on select chromosomes to date. To overcome this limitation, we generate transgenic mice with knocked-in MADM cassettes near the centromeres of all 19 autosomes and validate their use across organs. With this resource, >96% of the entire mouse genome can now be subjected to single-cell genetic mosaic analysis. Beyond a proof of principle, we apply our MADM library to systematically trace sister chromatid segregation in distinct mitotic cell lineages. We find striking chromosome-specific biases in segregation patterns, reflecting a putative mechanism for the asymmetric segregation of genetic determinants in somatic stem cell division."}],"issue":"12","file":[{"file_id":"9613","relation":"main_file","success":1,"date_created":"2021-06-28T14:06:24Z","file_size":7653149,"checksum":"d49520fdcbbb5c2f883bddb67cee5d77","content_type":"application/pdf","file_name":"2021_CellReports_Contreras.pdf","creator":"asandaue","date_updated":"2021-06-28T14:06:24Z","access_level":"open_access"}],"intvolume":"        35","file_date_updated":"2021-06-28T14:06:24Z","month":"06","type":"journal_article","language":[{"iso":"eng"}],"acknowledgement":"We thank the Bioimaging, Life Science, and Pre-Clinical Facilities at IST Austria; M.P. Postiglione, C. Simbriger, K. Valoskova, C. Schwayer, T. Hussain, M. Pieber, and V. Wimmer for initial experiments, technical support, and/or assistance; R. Shigemoto for sharing iv (Dnah11 mutant) mice; and M. Sixt and all members of the Hippenmeyer lab for discussion. This work was supported by National Institutes of Health grants ( R01-NS050580 to L.L. and F32MH096361 to L.A.S.). L.L. is an investigator of HHMI. N.A. received support from FWF Firnberg-Programm ( T 1031 ). A.H.H. is a recipient of a DOC Fellowship (24812) of the Austrian Academy of Sciences . This work also received support from IST Austria institutional funds , FWF SFB F78 to S.H., the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme ( FP7/2007-2013 ) under REA grant agreement no 618444 to S.H., and the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 725780 LinPro ) to S.H.","quality_controlled":"1","publication_status":"published","article_number":"109274","status":"public"},{"publication_identifier":{"eissn":["1553-7404"]},"oa":1,"citation":{"ieee":"Á. Inglés Prieto <i>et al.</i>, “Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease,” <i>PLoS genetics</i>, vol. 17, no. 4. Public Library of Science, p. e1009479, 2021.","mla":"Inglés Prieto, Álvaro, et al. “Optogenetic Delivery of Trophic Signals in a Genetic Model of Parkinson’s Disease.” <i>PLoS Genetics</i>, vol. 17, no. 4, Public Library of Science, 2021, p. e1009479, doi:<a href=\"https://doi.org/10.1371/journal.pgen.1009479\">10.1371/journal.pgen.1009479</a>.","chicago":"Inglés Prieto, Álvaro, Nikolas Furthmann, Samuel H. Crossman, Alexandra Madelaine Tichy, Nina Hoyer, Meike Petersen, Vanessa Zheden, et al. “Optogenetic Delivery of Trophic Signals in a Genetic Model of Parkinson’s Disease.” <i>PLoS Genetics</i>. Public Library of Science, 2021. <a href=\"https://doi.org/10.1371/journal.pgen.1009479\">https://doi.org/10.1371/journal.pgen.1009479</a>.","ama":"Inglés Prieto Á, Furthmann N, Crossman SH, et al. Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease. <i>PLoS genetics</i>. 2021;17(4):e1009479. doi:<a href=\"https://doi.org/10.1371/journal.pgen.1009479\">10.1371/journal.pgen.1009479</a>","apa":"Inglés Prieto, Á., Furthmann, N., Crossman, S. H., Tichy, A. M., Hoyer, N., Petersen, M., … Janovjak, H. L. (2021). Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease. <i>PLoS Genetics</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pgen.1009479\">https://doi.org/10.1371/journal.pgen.1009479</a>","short":"Á. Inglés Prieto, N. Furthmann, S.H. Crossman, A.M. Tichy, N. Hoyer, M. Petersen, V. Zheden, J. Bicher, E. Gschaider-Reichhart, A. György, D.E. Siekhaus, P. Soba, K.F. Winklhofer, H.L. Janovjak, PLoS Genetics 17 (2021) e1009479.","ista":"Inglés Prieto Á, Furthmann N, Crossman SH, Tichy AM, Hoyer N, Petersen M, Zheden V, Bicher J, Gschaider-Reichhart E, György A, Siekhaus DE, Soba P, Winklhofer KF, Janovjak HL. 2021. Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease. PLoS genetics. 17(4), e1009479."},"scopus_import":"1","title":"Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease","article_processing_charge":"No","author":[{"first_name":"Álvaro","last_name":"Inglés Prieto","id":"2A9DB292-F248-11E8-B48F-1D18A9856A87","full_name":"Inglés Prieto, Álvaro","orcid":"0000-0002-5409-8571"},{"full_name":"Furthmann, Nikolas","first_name":"Nikolas","last_name":"Furthmann"},{"first_name":"Samuel H.","last_name":"Crossman","full_name":"Crossman, Samuel H."},{"full_name":"Tichy, Alexandra Madelaine","last_name":"Tichy","first_name":"Alexandra Madelaine"},{"full_name":"Hoyer, Nina","first_name":"Nina","last_name":"Hoyer"},{"first_name":"Meike","last_name":"Petersen","full_name":"Petersen, Meike"},{"id":"39C5A68A-F248-11E8-B48F-1D18A9856A87","last_name":"Zheden","first_name":"Vanessa","orcid":"0000-0002-9438-4783","full_name":"Zheden, Vanessa"},{"first_name":"Julia","last_name":"Bicher","id":"3CCBB46E-F248-11E8-B48F-1D18A9856A87","full_name":"Bicher, Julia"},{"orcid":"0000-0002-7218-7738","full_name":"Gschaider-Reichhart, Eva","id":"3FEE232A-F248-11E8-B48F-1D18A9856A87","last_name":"Gschaider-Reichhart","first_name":"Eva"},{"id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87","last_name":"György","first_name":"Attila","orcid":"0000-0002-1819-198X","full_name":"György, Attila"},{"first_name":"Daria E","last_name":"Siekhaus","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","full_name":"Siekhaus, Daria E","orcid":"0000-0001-8323-8353"},{"first_name":"Peter","last_name":"Soba","full_name":"Soba, Peter"},{"full_name":"Winklhofer, Konstanze F.","last_name":"Winklhofer","first_name":"Konstanze F."},{"id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","last_name":"Janovjak","first_name":"Harald L","orcid":"0000-0002-8023-9315","full_name":"Janovjak, Harald L"}],"doi":"10.1371/journal.pgen.1009479","pmid":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2021-04-01T00:00:00Z","department":[{"_id":"EM-Fac"},{"_id":"LoSw"},{"_id":"DaSi"}],"external_id":{"isi":["000640606700001"],"pmid":["33857132"]},"year":"2021","has_accepted_license":"1","_id":"9363","date_updated":"2026-04-02T14:07:10Z","publisher":"Public Library of Science","publication":"PLoS genetics","date_created":"2021-05-02T22:01:29Z","day":"01","ddc":["570"],"volume":17,"oa_version":"Published Version","isi":1,"issue":"4","abstract":[{"text":"Optogenetics has been harnessed to shed new mechanistic light on current and future therapeutic strategies. This has been to date achieved by the regulation of ion flow and electrical signals in neuronal cells and neural circuits that are known to be affected by disease. In contrast, the optogenetic delivery of trophic biochemical signals, which support cell survival and are implicated in degenerative disorders, has never been demonstrated in an animal model of disease. Here, we reengineered the human and Drosophila melanogaster REarranged during Transfection (hRET and dRET) receptors to be activated by light, creating one-component optogenetic tools termed Opto-hRET and Opto-dRET. Upon blue light stimulation, these receptors robustly induced the MAPK/ERK proliferative signaling pathway in cultured cells. In PINK1B9 flies that exhibit loss of PTEN-induced putative kinase 1 (PINK1), a kinase associated with familial Parkinson’s disease (PD), light activation of Opto-dRET suppressed mitochondrial defects, tissue degeneration and behavioral deficits. In human cells with PINK1 loss-of-function, mitochondrial fragmentation was rescued using Opto-dRET via the PI3K/NF-кB pathway. Our results demonstrate that a light-activated receptor can ameliorate disease hallmarks in a genetic model of PD. The optogenetic delivery of trophic signals is cell type-specific and reversible and thus has the potential to inspire novel strategies towards a spatio-temporal regulation of tissue repair.","lang":"eng"}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"intvolume":"        17","file":[{"access_level":"open_access","date_updated":"2021-05-04T09:05:27Z","creator":"kschuh","file_name":"2021_PLOS_Ingles-Prieto.pdf","content_type":"application/pdf","checksum":"82a74668f863e8dfb22fdd4f845c92ce","file_size":3072764,"date_created":"2021-05-04T09:05:27Z","success":1,"file_id":"9369","relation":"main_file"}],"month":"04","file_date_updated":"2021-05-04T09:05:27Z","acknowledgement":"We thank R. Cagan, A. Whitworth and J. Nagpal for fly lines and advice, S. Herlitze for provision of a tissue culture illuminator, and Verian Bader for help with statistical analysis.","type":"journal_article","language":[{"iso":"eng"}],"publication_status":"published","page":"e1009479","status":"public","quality_controlled":"1"},{"scopus_import":"1","publication_identifier":{"eissn":["2041-1723"]},"oa":1,"citation":{"chicago":"Tkadlec, Josef, Andreas Pavlogiannis, Krishnendu Chatterjee, and Martin A. Nowak. “Fast and Strong Amplifiers of Natural Selection.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-24271-w\">https://doi.org/10.1038/s41467-021-24271-w</a>.","ieee":"J. Tkadlec, A. Pavlogiannis, K. Chatterjee, and M. A. Nowak, “Fast and strong amplifiers of natural selection,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021.","mla":"Tkadlec, Josef, et al. “Fast and Strong Amplifiers of Natural Selection.” <i>Nature Communications</i>, vol. 12, no. 1, 4009, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-24271-w\">10.1038/s41467-021-24271-w</a>.","apa":"Tkadlec, J., Pavlogiannis, A., Chatterjee, K., &#38; Nowak, M. A. (2021). Fast and strong amplifiers of natural selection. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-24271-w\">https://doi.org/10.1038/s41467-021-24271-w</a>","short":"J. Tkadlec, A. Pavlogiannis, K. Chatterjee, M.A. Nowak, Nature Communications 12 (2021).","ista":"Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. 2021. Fast and strong amplifiers of natural selection. Nature Communications. 12(1), 4009.","ama":"Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. Fast and strong amplifiers of natural selection. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-24271-w\">10.1038/s41467-021-24271-w</a>"},"doi":"10.1038/s41467-021-24271-w","pmid":1,"title":"Fast and strong amplifiers of natural selection","author":[{"id":"3F24CCC8-F248-11E8-B48F-1D18A9856A87","first_name":"Josef","last_name":"Tkadlec","orcid":"0000-0002-1097-9684","full_name":"Tkadlec, Josef"},{"full_name":"Pavlogiannis, Andreas","orcid":"0000-0002-8943-0722","last_name":"Pavlogiannis","first_name":"Andreas","id":"49704004-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Krishnendu","last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X"},{"first_name":"Martin A.","last_name":"Nowak","full_name":"Nowak, Martin A."}],"article_processing_charge":"No","has_accepted_license":"1","_id":"9640","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2021-06-29T00:00:00Z","external_id":{"isi":["000671752100003"],"pmid":["34188036"]},"project":[{"call_identifier":"FP7","grant_number":"279307","_id":"2581B60A-B435-11E9-9278-68D0E5697425","name":"Quantitative Graph Games: Theory and Applications"},{"name":"Formal Methods for Stochastic Models: Algorithms and Applications","call_identifier":"H2020","grant_number":"863818","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E"},{"name":"Modern Graph Algorithmic Techniques in Formal Verification","_id":"2584A770-B435-11E9-9278-68D0E5697425","grant_number":"P 23499-N23","call_identifier":"FWF"},{"name":"Rigorous Systems Engineering","call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425","grant_number":"S 11407_N23"}],"department":[{"_id":"KrCh"}],"year":"2021","publisher":"Springer Nature","date_updated":"2026-04-02T14:04:10Z","date_created":"2021-07-11T22:01:15Z","publication":"Nature Communications","issue":"1","abstract":[{"lang":"eng","text":"Selection and random drift determine the probability that novel mutations fixate in a population. Population structure is known to affect the dynamics of the evolutionary process. Amplifiers of selection are population structures that increase the fixation probability of beneficial mutants compared to well-mixed populations. Over the past 15 years, extensive research has produced remarkable structures called strong amplifiers which guarantee that every beneficial mutation fixates with high probability. But strong amplification has come at the cost of considerably delaying the fixation event, which can slow down the overall rate of evolution. However, the precise relationship between fixation probability and time has remained elusive. Here we characterize the slowdown effect of strong amplification. First, we prove that all strong amplifiers must delay the fixation event at least to some extent. Second, we construct strong amplifiers that delay the fixation event only marginally as compared to the well-mixed populations. Our results thus establish a tight relationship between fixation probability and time: Strong amplification always comes at a cost of a slowdown, but more than a marginal slowdown is not needed."}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","day":"29","ddc":["510"],"volume":12,"oa_version":"Published Version","ec_funded":1,"isi":1,"month":"06","file_date_updated":"2021-07-19T13:02:20Z","intvolume":"        12","file":[{"file_id":"9692","relation":"main_file","success":1,"date_created":"2021-07-19T13:02:20Z","file_size":628992,"checksum":"5767418926a7f7fb76151de29473dae0","content_type":"application/pdf","file_name":"2021_NatCoom_Tkadlec.pdf","creator":"cziletti","date_updated":"2021-07-19T13:02:20Z","access_level":"open_access"}],"publication_status":"published","article_number":"4009","status":"public","quality_controlled":"1","acknowledgement":"K.C. acknowledges support from ERC Start grant no. (279307: Graph Games), ERC Consolidator grant no. (863818: ForM-SMart), Austrian Science Fund (FWF) grant no. P23499-N23 and S11407-N23 (RiSE). M.A.N. acknowledges support from Office of Naval Research grant N00014-16-1-2914 and from the John Templeton Foundation.","type":"journal_article","language":[{"iso":"eng"}]},{"doi":"10.1038/s42005-021-00753-7","title":"Generation of spin currents by a temperature gradient in a two-terminal device","article_processing_charge":"No","author":[{"last_name":"Barfknecht","first_name":"Rafael E.","full_name":"Barfknecht, Rafael E."},{"full_name":"Foerster, Angela","last_name":"Foerster","first_name":"Angela"},{"full_name":"Zinner, Nikolaj T.","last_name":"Zinner","first_name":"Nikolaj T."},{"orcid":"0000-0003-0393-5525","full_name":"Volosniev, Artem","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","first_name":"Artem","last_name":"Volosniev"}],"arxiv":1,"scopus_import":"1","publication_identifier":{"eissn":["2399-3650"]},"oa":1,"citation":{"ieee":"R. E. Barfknecht, A. Foerster, N. T. Zinner, and A. Volosniev, “Generation of spin currents by a temperature gradient in a two-terminal device,” <i>Communications Physics</i>, vol. 4, no. 1. Springer Nature, 2021.","mla":"Barfknecht, Rafael E., et al. “Generation of Spin Currents by a Temperature Gradient in a Two-Terminal Device.” <i>Communications Physics</i>, vol. 4, no. 1, 252, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s42005-021-00753-7\">10.1038/s42005-021-00753-7</a>.","chicago":"Barfknecht, Rafael E., Angela Foerster, Nikolaj T. Zinner, and Artem Volosniev. “Generation of Spin Currents by a Temperature Gradient in a Two-Terminal Device.” <i>Communications Physics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s42005-021-00753-7\">https://doi.org/10.1038/s42005-021-00753-7</a>.","ama":"Barfknecht RE, Foerster A, Zinner NT, Volosniev A. Generation of spin currents by a temperature gradient in a two-terminal device. <i>Communications Physics</i>. 2021;4(1). doi:<a href=\"https://doi.org/10.1038/s42005-021-00753-7\">10.1038/s42005-021-00753-7</a>","short":"R.E. Barfknecht, A. Foerster, N.T. Zinner, A. Volosniev, Communications Physics 4 (2021).","apa":"Barfknecht, R. E., Foerster, A., Zinner, N. T., &#38; Volosniev, A. (2021). Generation of spin currents by a temperature gradient in a two-terminal device. <i>Communications Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42005-021-00753-7\">https://doi.org/10.1038/s42005-021-00753-7</a>","ista":"Barfknecht RE, Foerster A, Zinner NT, Volosniev A. 2021. Generation of spin currents by a temperature gradient in a two-terminal device. Communications Physics. 4(1), 252."},"publisher":"Springer Nature","date_updated":"2026-04-02T14:05:00Z","has_accepted_license":"1","_id":"10401","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2021-11-26T00:00:00Z","year":"2021","department":[{"_id":"MiLe"}],"project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"}],"external_id":{"isi":["000722867600002"],"arxiv":["2101.02020"]},"abstract":[{"lang":"eng","text":"Theoretical and experimental studies of the interaction between spins and temperature are vital for the development of spin caloritronics, as they dictate the design of future devices. In this work, we propose a two-terminal cold-atom simulator to study that interaction. The proposed quantum simulator consists of strongly interacting atoms that occupy two temperature reservoirs connected by a one-dimensional link. First, we argue that the dynamics in the link can be described using an inhomogeneous Heisenberg spin chain whose couplings are defined by the local temperature. Second, we show the existence of a spin current in a system with a temperature difference by studying the dynamics that follows the spin-flip of an atom in the link. A temperature gradient accelerates the impurity in one direction more than in the other, leading to an overall spin current similar to the spin Seebeck effect."}],"issue":"1","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","ddc":["530"],"day":"26","oa_version":"Published Version","volume":4,"isi":1,"ec_funded":1,"publication":"Communications Physics","date_created":"2021-12-05T23:01:39Z","article_number":"252","publication_status":"published","status":"public","quality_controlled":"1","acknowledgement":"The authors acknowledge support from the European QuantERA ERA-NET Cofund in Quantum Technologies (Project QTFLAG Grant Agreement No. 731473) (R.E.B), CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) Brazil (A.F.), the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411 (A.G.V.), the Independent Research Fund Denmark, the Carlsberg Foundation, and Aarhus University Research Foundation under the Jens Christian Skou fellowship program (N.T.Z).","language":[{"iso":"eng"}],"type":"journal_article","month":"11","file_date_updated":"2021-12-06T14:53:41Z","intvolume":"         4","file":[{"file_name":"2021_NatComm_Barfknecht.pdf","creator":"alisjak","date_updated":"2021-12-06T14:53:41Z","access_level":"open_access","file_id":"10420","relation":"main_file","success":1,"date_created":"2021-12-06T14:53:41Z","checksum":"9097319952cb9a3d96e7fd3aa9813a03","file_size":1068984,"content_type":"application/pdf"}]},{"citation":{"ama":"Picard MAL, Vicoso B, Bertrand S, Escriva H. Diversity of modes of reproduction and sex determination systems in invertebrates, and the putative contribution of genetic conflict. <i>Genes</i>. 2021;12(8). doi:<a href=\"https://doi.org/10.3390/genes12081136\">10.3390/genes12081136</a>","short":"M.A.L. Picard, B. Vicoso, S. Bertrand, H. Escriva, Genes 12 (2021).","apa":"Picard, M. A. L., Vicoso, B., Bertrand, S., &#38; Escriva, H. (2021). Diversity of modes of reproduction and sex determination systems in invertebrates, and the putative contribution of genetic conflict. <i>Genes</i>. MDPI. <a href=\"https://doi.org/10.3390/genes12081136\">https://doi.org/10.3390/genes12081136</a>","ista":"Picard MAL, Vicoso B, Bertrand S, Escriva H. 2021. Diversity of modes of reproduction and sex determination systems in invertebrates, and the putative contribution of genetic conflict. Genes. 12(8), 1136.","ieee":"M. A. L. Picard, B. Vicoso, S. Bertrand, and H. Escriva, “Diversity of modes of reproduction and sex determination systems in invertebrates, and the putative contribution of genetic conflict,” <i>Genes</i>, vol. 12, no. 8. MDPI, 2021.","mla":"Picard, Marion A. L., et al. “Diversity of Modes of Reproduction and Sex Determination Systems in Invertebrates, and the Putative Contribution of Genetic Conflict.” <i>Genes</i>, vol. 12, no. 8, 1136, MDPI, 2021, doi:<a href=\"https://doi.org/10.3390/genes12081136\">10.3390/genes12081136</a>.","chicago":"Picard, Marion A L, Beatriz Vicoso, Stéphanie Bertrand, and Hector Escriva. “Diversity of Modes of Reproduction and Sex Determination Systems in Invertebrates, and the Putative Contribution of Genetic Conflict.” <i>Genes</i>. MDPI, 2021. <a href=\"https://doi.org/10.3390/genes12081136\">https://doi.org/10.3390/genes12081136</a>."},"publication_identifier":{"eissn":["2073-4425"]},"oa":1,"scopus_import":"1","author":[{"full_name":"Picard, Marion A L","orcid":"0000-0002-8101-2518","first_name":"Marion A L","last_name":"Picard","id":"2C921A7A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Beatriz","last_name":"Vicoso","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306"},{"full_name":"Bertrand, Stéphanie","last_name":"Bertrand","first_name":"Stéphanie"},{"full_name":"Escriva, Hector","last_name":"Escriva","first_name":"Hector"}],"article_processing_charge":"Yes","title":"Diversity of modes of reproduction and sex determination systems in invertebrates, and the putative contribution of genetic conflict","doi":"10.3390/genes12081136","pmid":1,"date_published":"2021-08-01T00:00:00Z","external_id":{"pmid":["34440310"],"isi":["000690475900001"]},"year":"2021","project":[{"name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","_id":"250BDE62-B435-11E9-9278-68D0E5697425","grant_number":"715257","call_identifier":"H2020"}],"department":[{"_id":"BeVi"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"9908","has_accepted_license":"1","date_updated":"2026-04-02T14:05:14Z","publisher":"MDPI","publication":"Genes","date_created":"2021-08-15T22:01:27Z","ec_funded":1,"isi":1,"ddc":["570"],"day":"01","oa_version":"Published Version","volume":12,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"review","abstract":[{"lang":"eng","text":"About eight million animal species are estimated to live on Earth, and all except those belonging to one subphylum are invertebrates. Invertebrates are incredibly diverse in their morphologies, life histories, and in the range of the ecological niches that they occupy. A great variety of modes of reproduction and sex determination systems is also observed among them, and their mosaic-distribution across the phylogeny shows that transitions between them occur frequently and rapidly. Genetic conflict in its various forms is a long-standing theory to explain what drives those evolutionary transitions. Here, we review (1) the different modes of reproduction among invertebrate species, highlighting sexual reproduction as the probable ancestral state; (2) the paradoxical diversity of sex determination systems; (3) the different types of genetic conflicts that could drive the evolution of such different systems."}],"issue":"8","file":[{"access_level":"open_access","file_name":"2021_Genes_Picard.pdf","date_updated":"2021-08-16T09:49:35Z","creator":"asandaue","content_type":"application/pdf","file_id":"9926","relation":"main_file","file_size":2297655,"checksum":"744e60e56d290a96da3c91a9779f886f","date_created":"2021-08-16T09:49:35Z","success":1}],"intvolume":"        12","file_date_updated":"2021-08-16T09:49:35Z","month":"08","language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","publication_status":"published","article_number":"1136","status":"public"},{"date_created":"2021-03-21T23:01:19Z","publication":"Letters in Mathematical Physics","volume":111,"oa_version":"Published Version","day":"09","ddc":["510"],"isi":1,"abstract":[{"text":"We consider the ferromagnetic quantum Heisenberg model in one dimension, for any spin S≥1/2. We give upper and lower bounds on the free energy, proving that at low temperature it is asymptotically equal to the one of an ideal Bose gas of magnons, as predicted by the spin-wave approximation. The trial state used in the upper bound yields an analogous estimate also in the case of two spatial dimensions, which is believed to be sharp at low temperature.","lang":"eng"}],"issue":"2","article_type":"original","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"intvolume":"       111","file":[{"access_level":"open_access","file_name":"2021_LettersMathPhysics_Napiorkowski.pdf","date_updated":"2021-03-22T11:01:09Z","creator":"dernst","content_type":"application/pdf","file_id":"9273","relation":"main_file","checksum":"687fef1525789c0950de90468dd81604","file_size":397962,"date_created":"2021-03-22T11:01:09Z","success":1}],"month":"03","file_date_updated":"2021-03-22T11:01:09Z","acknowledgement":"The work of MN was supported by the National Science Centre (NCN) Project Nr. 2016/21/D/ST1/02430. The work of RS was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 694227).\r\nOpen access funding provided by Institute of Science and Technology (IST Austria).","type":"journal_article","language":[{"iso":"eng"}],"status":"public","publication_status":"published","article_number":"31","quality_controlled":"1","oa":1,"publication_identifier":{"eissn":["1573-0530"],"issn":["0377-9017"]},"citation":{"ama":"Napiórkowski MM, Seiringer R. Free energy asymptotics of the quantum Heisenberg spin chain. <i>Letters in Mathematical Physics</i>. 2021;111(2). doi:<a href=\"https://doi.org/10.1007/s11005-021-01375-4\">10.1007/s11005-021-01375-4</a>","ista":"Napiórkowski MM, Seiringer R. 2021. Free energy asymptotics of the quantum Heisenberg spin chain. Letters in Mathematical Physics. 111(2), 31.","short":"M.M. Napiórkowski, R. Seiringer, Letters in Mathematical Physics 111 (2021).","apa":"Napiórkowski, M. M., &#38; Seiringer, R. (2021). Free energy asymptotics of the quantum Heisenberg spin chain. <i>Letters in Mathematical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11005-021-01375-4\">https://doi.org/10.1007/s11005-021-01375-4</a>","mla":"Napiórkowski, Marcin M., and Robert Seiringer. “Free Energy Asymptotics of the Quantum Heisenberg Spin Chain.” <i>Letters in Mathematical Physics</i>, vol. 111, no. 2, 31, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1007/s11005-021-01375-4\">10.1007/s11005-021-01375-4</a>.","ieee":"M. M. Napiórkowski and R. Seiringer, “Free energy asymptotics of the quantum Heisenberg spin chain,” <i>Letters in Mathematical Physics</i>, vol. 111, no. 2. Springer Nature, 2021.","chicago":"Napiórkowski, Marcin M, and Robert Seiringer. “Free Energy Asymptotics of the Quantum Heisenberg Spin Chain.” <i>Letters in Mathematical Physics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s11005-021-01375-4\">https://doi.org/10.1007/s11005-021-01375-4</a>."},"scopus_import":"1","title":"Free energy asymptotics of the quantum Heisenberg spin chain","author":[{"first_name":"Marcin M","last_name":"Napiórkowski","id":"4197AD04-F248-11E8-B48F-1D18A9856A87","full_name":"Napiórkowski, Marcin M"},{"full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","first_name":"Robert","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"article_processing_charge":"Yes (via OA deal)","pmid":1,"doi":"10.1007/s11005-021-01375-4","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","external_id":{"pmid":["33785980"],"isi":["000626837400001"]},"year":"2021","department":[{"_id":"RoSe"}],"date_published":"2021-03-09T00:00:00Z","has_accepted_license":"1","_id":"9256","date_updated":"2026-04-02T14:06:48Z","publisher":"Springer Nature"},{"type":"journal_article","language":[{"iso":"eng"}],"acknowledgement":"RP acknowledges the Department of Science and Technology, India for the support through the DST-INSPIRE Faculty Award (DST/INSPIRE/04/2015/001939). This work was supported by the Engineering and Physical Sciences Research Council (EPSRC), United Kingdom (Grant numbers EP/J018295/1, EP/J018392/1, EP/N014391/1). The contribution of RP was also supported by the later Grant. This work was generously supported by the Welcome Trust Institutional Strategic Support Award (204909/Z/16/Z) too. The contribution of MG was supported by the EPSRC via EP/N014391/1 and a Wellcome Trust Institutional Strategic Support Award (WT105618MA). The contribution of YA was generously supported by the Wellcome Trust Institutional Strategic Support Award (WT105618MA).","quality_controlled":"1","status":"public","publication_status":"published","article_number":"2204","file":[{"content_type":"application/pdf","relation":"main_file","file_id":"9106","file_size":2885056,"checksum":"e8a68df48750712671f5c47b0228e531","date_created":"2021-02-09T07:33:23Z","success":1,"access_level":"open_access","file_name":"2021_ScientificReports_Pandey.pdf","date_updated":"2021-02-09T07:33:23Z","creator":"dernst"}],"intvolume":"        11","file_date_updated":"2021-02-09T07:33:23Z","month":"01","isi":1,"oa_version":"Published Version","volume":11,"ddc":["570"],"day":"26","article_type":"original","OA_place":"publisher","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"lang":"eng","text":"Psoriasis is a chronic inflammatory skin disease clinically characterized by the appearance of red colored, well-demarcated plaques with thickened skin and with silvery scales. Recent studies have established the involvement of a complex signalling network of interactions between cytokines, immune cells and skin cells called keratinocytes. Keratinocytes form the cells of the outermost layer of the skin (epidermis). Visible plaques in psoriasis are developed due to the fast proliferation and unusual differentiation of keratinocyte cells. Despite that, the exact mechanism of the appearance of these plaques in the cytokine-immune cell network is not clear. A mathematical model embodying interactions between key immune cells believed to be involved in psoriasis, keratinocytes and relevant cytokines has been developed. The complex network formed of these interactions poses several challenges. Here, we choose to study subnetworks of this complex network and initially focus on interactions involving TNFα, IL-23/IL-17, and IL-15. These are chosen based on known evidence of their therapeutic efficacy. In addition, we explore the role of IL-15 in the pathogenesis of psoriasis and its potential as a future drug target for a novel treatment option. We perform steady state analyses for these subnetworks and demonstrate that the interactions between cells, driven by cytokines could cause the emergence of a psoriasis state (hyper-proliferation of keratinocytes) when levels of TNFα, IL-23/IL-17 or IL-15 are increased. The model results explain and support the clinical potentiality of anti-cytokine treatments. Interestingly, our results suggest different dynamic scenarios underpin the pathogenesis of psoriasis, depending upon the dominant cytokines of subnetworks. We observed that the increase in the level of IL-23/IL-17 and IL-15 could lead to psoriasis via a bistable route, whereas an increase in the level of TNFα would lead to a monotonic and gradual disease progression. Further, we demonstrate how this insight, bistability, could be exploited to improve the current therapies and develop novel treatment strategies for psoriasis."}],"publication":"Scientific Reports","date_created":"2021-02-07T23:01:12Z","OA_type":"gold","date_updated":"2026-04-02T14:16:22Z","publisher":"Springer Nature","external_id":{"isi":["000667506800004"],"pmid":["33500449"]},"year":"2021","DOAJ_listed":"1","date_published":"2021-01-26T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"9097","has_accepted_license":"1","author":[{"full_name":"Pandey, Rakesh","first_name":"Rakesh","last_name":"Pandey"},{"first_name":"Yusur","last_name":"Al-Nuaimi","full_name":"Al-Nuaimi, Yusur"},{"full_name":"Mishra, Rajiv Kumar","last_name":"Mishra","first_name":"Rajiv Kumar","id":"46CB58F2-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Sarah K.","last_name":"Spurgeon","full_name":"Spurgeon, Sarah K."},{"full_name":"Goodfellow, Marc","first_name":"Marc","last_name":"Goodfellow"}],"article_processing_charge":"No","title":"Role of subnetworks mediated by TNF α, IL-23/IL-17 and IL-15 in a network involved in the pathogenesis of psoriasis","pmid":1,"doi":"10.1038/s41598-020-80507-7","citation":{"ieee":"R. Pandey, Y. Al-Nuaimi, R. K. Mishra, S. K. Spurgeon, and M. Goodfellow, “Role of subnetworks mediated by TNF α, IL-23/IL-17 and IL-15 in a network involved in the pathogenesis of psoriasis,” <i>Scientific Reports</i>, vol. 11. Springer Nature, 2021.","mla":"Pandey, Rakesh, et al. “Role of Subnetworks Mediated by TNF α, IL-23/IL-17 and IL-15 in a Network Involved in the Pathogenesis of Psoriasis.” <i>Scientific Reports</i>, vol. 11, 2204, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41598-020-80507-7\">10.1038/s41598-020-80507-7</a>.","chicago":"Pandey, Rakesh, Yusur Al-Nuaimi, Rajiv Kumar Mishra, Sarah K. Spurgeon, and Marc Goodfellow. “Role of Subnetworks Mediated by TNF α, IL-23/IL-17 and IL-15 in a Network Involved in the Pathogenesis of Psoriasis.” <i>Scientific Reports</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41598-020-80507-7\">https://doi.org/10.1038/s41598-020-80507-7</a>.","ama":"Pandey R, Al-Nuaimi Y, Mishra RK, Spurgeon SK, Goodfellow M. Role of subnetworks mediated by TNF α, IL-23/IL-17 and IL-15 in a network involved in the pathogenesis of psoriasis. <i>Scientific Reports</i>. 2021;11. doi:<a href=\"https://doi.org/10.1038/s41598-020-80507-7\">10.1038/s41598-020-80507-7</a>","short":"R. Pandey, Y. Al-Nuaimi, R.K. Mishra, S.K. Spurgeon, M. Goodfellow, Scientific Reports 11 (2021).","apa":"Pandey, R., Al-Nuaimi, Y., Mishra, R. K., Spurgeon, S. K., &#38; Goodfellow, M. (2021). Role of subnetworks mediated by TNF α, IL-23/IL-17 and IL-15 in a network involved in the pathogenesis of psoriasis. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-020-80507-7\">https://doi.org/10.1038/s41598-020-80507-7</a>","ista":"Pandey R, Al-Nuaimi Y, Mishra RK, Spurgeon SK, Goodfellow M. 2021. Role of subnetworks mediated by TNF α, IL-23/IL-17 and IL-15 in a network involved in the pathogenesis of psoriasis. Scientific Reports. 11, 2204."},"publication_identifier":{"eissn":["2045-2322"]},"oa":1,"scopus_import":"1"},{"has_accepted_license":"1","_id":"8430","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","external_id":{"pmid":["33879782"],"isi":["000642509600006"]},"year":"2021","department":[{"_id":"MaRo"}],"project":[{"grant_number":"PCEGP3_181181","_id":"9B8D11D6-BA93-11EA-9121-9846C619BF3A","name":"Improving estimation and prediction of common complex disease risk"}],"date_published":"2021-04-20T00:00:00Z","publisher":"Nature Research","date_updated":"2026-04-03T09:31:17Z","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/predicting-the-onset-of-diseases/","relation":"press_release"}]},"scopus_import":"1","publication_identifier":{"eissn":["2041-1723"]},"oa":1,"citation":{"ama":"Ojavee SE, Kousathanas A, Trejo Banos D, et al. Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-22538-w\">10.1038/s41467-021-22538-w</a>","ista":"Ojavee SE, Kousathanas A, Trejo Banos D, Orliac EJ, Patxot M, Lall K, Magi R, Fischer K, Kutalik Z, Robinson MR. 2021. Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis. Nature Communications. 12(1), 2337.","apa":"Ojavee, S. E., Kousathanas, A., Trejo Banos, D., Orliac, E. J., Patxot, M., Lall, K., … Robinson, M. R. (2021). Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis. <i>Nature Communications</i>. Nature Research. <a href=\"https://doi.org/10.1038/s41467-021-22538-w\">https://doi.org/10.1038/s41467-021-22538-w</a>","short":"S.E. Ojavee, A. Kousathanas, D. Trejo Banos, E.J. Orliac, M. Patxot, K. Lall, R. Magi, K. Fischer, Z. Kutalik, M.R. Robinson, Nature Communications 12 (2021).","mla":"Ojavee, Sven E., et al. “Genomic Architecture and Prediction of Censored Time-to-Event Phenotypes with a Bayesian Genome-Wide Analysis.” <i>Nature Communications</i>, vol. 12, no. 1, 2337, Nature Research, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-22538-w\">10.1038/s41467-021-22538-w</a>.","ieee":"S. E. Ojavee <i>et al.</i>, “Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis,” <i>Nature Communications</i>, vol. 12, no. 1. Nature Research, 2021.","chicago":"Ojavee, Sven E, Athanasios Kousathanas, Daniel Trejo Banos, Etienne J Orliac, Marion Patxot, Kristi Lall, Reedik Magi, Krista Fischer, Zoltan Kutalik, and Matthew Richard Robinson. “Genomic Architecture and Prediction of Censored Time-to-Event Phenotypes with a Bayesian Genome-Wide Analysis.” <i>Nature Communications</i>. Nature Research, 2021. <a href=\"https://doi.org/10.1038/s41467-021-22538-w\">https://doi.org/10.1038/s41467-021-22538-w</a>."},"pmid":1,"doi":"10.1038/s41467-021-22538-w","title":"Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis","author":[{"first_name":"Sven E","last_name":"Ojavee","full_name":"Ojavee, Sven E"},{"full_name":"Kousathanas, Athanasios","last_name":"Kousathanas","first_name":"Athanasios"},{"last_name":"Trejo Banos","first_name":"Daniel","full_name":"Trejo Banos, Daniel"},{"first_name":"Etienne J","last_name":"Orliac","full_name":"Orliac, Etienne J"},{"full_name":"Patxot, Marion","last_name":"Patxot","first_name":"Marion"},{"first_name":"Kristi","last_name":"Lall","full_name":"Lall, Kristi"},{"first_name":"Reedik","last_name":"Magi","full_name":"Magi, Reedik"},{"first_name":"Krista","last_name":"Fischer","full_name":"Fischer, Krista"},{"last_name":"Kutalik","first_name":"Zoltan","full_name":"Kutalik, Zoltan"},{"full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813","first_name":"Matthew Richard","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"}],"article_processing_charge":"No","month":"04","file_date_updated":"2021-05-04T15:07:50Z","intvolume":"        12","file":[{"file_id":"9372","relation":"main_file","success":1,"date_created":"2021-05-04T15:07:50Z","file_size":6474239,"checksum":"eca8b9ae713835c5b785211dd08d8a2e","content_type":"application/pdf","file_name":"2021_nature_communications_Ojavee.pdf","creator":"kschuh","date_updated":"2021-05-04T15:07:50Z","access_level":"open_access"}],"status":"public","article_number":"2337","publication_status":"published","quality_controlled":"1","acknowledgement":"This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science and Technology Austria and the University of Lausanne; the work of KF was supported by the grant PUT1665 by the Estonian Research Council. We would like to thank Mike Goddard for comments which greatly improved the work, the participants of the cohort studies, and the Ecole Polytechnique Federal Lausanne (EPFL) SCITAS for their excellent compute resources, their generosity with their time and the kindness of their support.","language":[{"iso":"eng"}],"type":"journal_article","publication":"Nature Communications","date_created":"2020-09-17T10:53:00Z","issue":"1","abstract":[{"text":"While recent advancements in computation and modelling have improved the analysis of complex traits, our understanding of the genetic basis of the time at symptom onset remains limited. Here, we develop a Bayesian approach (BayesW) that provides probabilistic inference of the genetic architecture of age-at-onset phenotypes in a sampling scheme that facilitates biobank-scale time-to-event analyses. We show in extensive simulation work the benefits BayesW provides in terms of number of discoveries, model performance and genomic prediction. In the UK Biobank, we find many thousands of common genomic regions underlying the age-at-onset of high blood pressure (HBP), cardiac disease (CAD), and type-2 diabetes (T2D), and for the genetic basis of onset reflecting the underlying genetic liability to disease. Age-at-menopause and age-at-menarche are also highly polygenic, but with higher variance contributed by low frequency variants. Genomic prediction into the Estonian Biobank data shows that BayesW gives higher prediction accuracy than other approaches.","lang":"eng"}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa_version":"Published Version","volume":12,"ddc":["570"],"day":"20","isi":1},{"volume":12,"oa_version":"Published Version","day":"10","ddc":["570"],"isi":1,"abstract":[{"lang":"eng","text":"High impact epidemics constitute one of the largest threats humanity is facing in the 21st century. In the absence of pharmaceutical interventions, physical distancing together with testing, contact tracing and quarantining are crucial in slowing down epidemic dynamics. Yet, here we show that if testing capacities are limited, containment may fail dramatically because such combined countermeasures drastically change the rules of the epidemic transition: Instead of continuous, the response to countermeasures becomes discontinuous. Rather than following the conventional exponential growth, the outbreak that is initially strongly suppressed eventually accelerates and scales faster than exponential during an explosive growth period. As a consequence, containment measures either suffice to stop the outbreak at low total case numbers or fail catastrophically if marginally too weak, thus implying large uncertainties in reliably estimating overall epidemic dynamics, both during initial phases and during second wave scenarios."}],"issue":"1","article_type":"original","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_created":"2021-05-23T22:01:42Z","publication":"Nature Communications","acknowledgement":"The authors thank Malte Schröder for valuable discussions and creating the scale-free network topologies. B.H. thanks Mukund Vasudevan for helpful discussion. The research by M.T. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany´s Excellence Strategy–EXC-2068–390729961–Cluster of Excellence Physics of Life of TU Dresden.","type":"journal_article","language":[{"iso":"eng"}],"status":"public","article_number":"2586","publication_status":"published","quality_controlled":"1","intvolume":"        12","file":[{"checksum":"fe26c1b8a7da1ae07a6c03f80ff06ea1","file_size":1176573,"success":1,"date_created":"2021-05-25T14:18:40Z","relation":"main_file","file_id":"9426","content_type":"application/pdf","date_updated":"2021-05-25T14:18:40Z","creator":"kschuh","file_name":"2021_NatureCommunications_Scarselli.pdf","access_level":"open_access"}],"month":"05","file_date_updated":"2021-05-25T14:18:40Z","title":"Discontinuous epidemic transition due to limited testing","author":[{"last_name":"Scarselli","first_name":"Davide","id":"40315C30-F248-11E8-B48F-1D18A9856A87","full_name":"Scarselli, Davide","orcid":"0000-0001-5227-4271"},{"id":"3EA1010E-F248-11E8-B48F-1D18A9856A87","last_name":"Budanur","first_name":"Nazmi B","orcid":"0000-0003-0423-5010","full_name":"Budanur, Nazmi B"},{"first_name":"Marc","last_name":"Timme","full_name":"Timme, Marc"},{"first_name":"Björn","last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","orcid":"0000-0003-2057-2754"}],"article_processing_charge":"No","pmid":1,"doi":"10.1038/s41467-021-22725-9","oa":1,"publication_identifier":{"eissn":["2041-1723"]},"citation":{"chicago":"Scarselli, Davide, Nazmi B Budanur, Marc Timme, and Björn Hof. “Discontinuous Epidemic Transition Due to Limited Testing.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-22725-9\">https://doi.org/10.1038/s41467-021-22725-9</a>.","ieee":"D. Scarselli, N. B. Budanur, M. Timme, and B. Hof, “Discontinuous epidemic transition due to limited testing,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021.","mla":"Scarselli, Davide, et al. “Discontinuous Epidemic Transition Due to Limited Testing.” <i>Nature Communications</i>, vol. 12, no. 1, 2586, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-22725-9\">10.1038/s41467-021-22725-9</a>.","apa":"Scarselli, D., Budanur, N. B., Timme, M., &#38; Hof, B. (2021). Discontinuous epidemic transition due to limited testing. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-22725-9\">https://doi.org/10.1038/s41467-021-22725-9</a>","short":"D. Scarselli, N.B. Budanur, M. Timme, B. Hof, Nature Communications 12 (2021).","ista":"Scarselli D, Budanur NB, Timme M, Hof B. 2021. Discontinuous epidemic transition due to limited testing. Nature Communications. 12(1), 2586.","ama":"Scarselli D, Budanur NB, Timme M, Hof B. Discontinuous epidemic transition due to limited testing. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-22725-9\">10.1038/s41467-021-22725-9</a>"},"scopus_import":"1","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/smashing-the-covid-curve/","relation":"press_release"}]},"date_updated":"2026-04-03T09:37:18Z","publisher":"Springer Nature","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","department":[{"_id":"BjHo"}],"external_id":{"isi":["000687305500044"],"pmid":["33972522"]},"year":"2021","date_published":"2021-05-10T00:00:00Z","has_accepted_license":"1","_id":"9407"},{"title":"Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain","author":[{"id":"41CB84B2-F248-11E8-B48F-1D18A9856A87","last_name":"Venturino","first_name":"Alessandro","orcid":"0000-0003-2356-9403","full_name":"Venturino, Alessandro"},{"full_name":"Schulz, Rouven","orcid":"0000-0001-5297-733X","first_name":"Rouven","last_name":"Schulz","id":"4C5E7B96-F248-11E8-B48F-1D18A9856A87"},{"full_name":"De Jesús-Cortés, Héctor","first_name":"Héctor","last_name":"De Jesús-Cortés"},{"id":"3838F452-F248-11E8-B48F-1D18A9856A87","last_name":"Maes","first_name":"Margaret E","orcid":"0000-0001-9642-1085","full_name":"Maes, Margaret E"},{"last_name":"Nagy","first_name":"Balint","id":"93C65ECC-A6F2-11E9-8DF9-9712E6697425","full_name":"Nagy, Balint"},{"first_name":"Francis","last_name":"Reilly-Andújar","full_name":"Reilly-Andújar, Francis"},{"first_name":"Gloria","last_name":"Colombo","id":"3483CF6C-F248-11E8-B48F-1D18A9856A87","full_name":"Colombo, Gloria","orcid":"0000-0001-9434-8902"},{"orcid":"0000-0003-0002-1867","full_name":"Cubero, Ryan J","id":"850B2E12-9CD4-11E9-837F-E719E6697425","last_name":"Cubero","first_name":"Ryan J"},{"id":"3526230C-F248-11E8-B48F-1D18A9856A87","first_name":"Florianne E","last_name":"Schoot Uiterkamp","full_name":"Schoot Uiterkamp, Florianne E"},{"first_name":"Mark F.","last_name":"Bear","full_name":"Bear, Mark F."},{"last_name":"Siegert","first_name":"Sandra","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","full_name":"Siegert, Sandra","orcid":"0000-0001-8635-0877"}],"article_processing_charge":"No","doi":"10.1016/j.celrep.2021.109313","pmid":1,"oa":1,"publication_identifier":{"eissn":["2211-1247"]},"citation":{"chicago":"Venturino, Alessandro, Rouven Schulz, Héctor De Jesús-Cortés, Margaret E Maes, Balint Nagy, Francis Reilly-Andújar, Gloria Colombo, et al. “Microglia Enable Mature Perineuronal Nets Disassembly upon Anesthetic Ketamine Exposure or 60-Hz Light Entrainment in the Healthy Brain.” <i>Cell Reports</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.celrep.2021.109313\">https://doi.org/10.1016/j.celrep.2021.109313</a>.","ieee":"A. Venturino <i>et al.</i>, “Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain,” <i>Cell Reports</i>, vol. 36, no. 1. Elsevier, 2021.","mla":"Venturino, Alessandro, et al. “Microglia Enable Mature Perineuronal Nets Disassembly upon Anesthetic Ketamine Exposure or 60-Hz Light Entrainment in the Healthy Brain.” <i>Cell Reports</i>, vol. 36, no. 1, 109313, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.celrep.2021.109313\">10.1016/j.celrep.2021.109313</a>.","short":"A. Venturino, R. Schulz, H. De Jesús-Cortés, M.E. Maes, B. Nagy, F. Reilly-Andújar, G. Colombo, R.J. Cubero, F.E. Miteva, M.F. Bear, S. Siegert, Cell Reports 36 (2021).","apa":"Venturino, A., Schulz, R., De Jesús-Cortés, H., Maes, M. E., Nagy, B., Reilly-Andújar, F., … Siegert, S. (2021). Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2021.109313\">https://doi.org/10.1016/j.celrep.2021.109313</a>","ista":"Venturino A, Schulz R, De Jesús-Cortés H, Maes ME, Nagy B, Reilly-Andújar F, Colombo G, Cubero RJ, Miteva FE, Bear MF, Siegert S. 2021. Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain. Cell Reports. 36(1), 109313.","ama":"Venturino A, Schulz R, De Jesús-Cortés H, et al. Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain. <i>Cell Reports</i>. 2021;36(1). doi:<a href=\"https://doi.org/10.1016/j.celrep.2021.109313\">10.1016/j.celrep.2021.109313</a>"},"related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/the-twinkle-and-the-brain/","relation":"press_release"}]},"scopus_import":"1","date_updated":"2026-04-03T09:46:05Z","publisher":"Elsevier","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2021-07-06T00:00:00Z","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","call_identifier":"H2020","name":"International IST Doctoral Program"},{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"name":"Microglia action towards neuronal circuit formation and function in health and disease","grant_number":"715571","_id":"25D4A630-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"external_id":{"pmid":["34233180"],"isi":["000670188500004"]},"year":"2021","department":[{"_id":"SaSi"}],"has_accepted_license":"1","_id":"9642","day":"06","ddc":["570"],"oa_version":"Published Version","volume":36,"ec_funded":1,"isi":1,"issue":"1","abstract":[{"lang":"eng","text":"Perineuronal nets (PNNs), components of the extracellular matrix, preferentially coat parvalbumin-positive interneurons and constrain critical-period plasticity in the adult cerebral cortex. Current strategies to remove PNN are long-lasting, invasive, and trigger neuropsychiatric symptoms. Here, we apply repeated anesthetic ketamine as a method with minimal behavioral effect. We find that this paradigm strongly reduces PNN coating in the healthy adult brain and promotes juvenile-like plasticity. Microglia are critically involved in PNN loss because they engage with parvalbumin-positive neurons in their defined cortical layer. We identify external 60-Hz light-flickering entrainment to recapitulate microglia-mediated PNN removal. Importantly, 40-Hz frequency, which is known to remove amyloid plaques, does not induce PNN loss, suggesting microglia might functionally tune to distinct brain frequencies. Thus, our 60-Hz light-entrainment strategy provides an alternative form of PNN intervention in the healthy adult brain."}],"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","date_created":"2021-07-11T22:01:16Z","publication":"Cell Reports","acknowledgement":"We thank the scientific service units at IST Austria, especially the IST bioimaging facility, the preclinical facility, and, specifically, Michael Schunn and Sonja Haslinger for excellent support; Plexxikon for the PLX food; the Csicsvari group for advice and equipment for in vivo recording; Jürgen Siegert for the light-entrainment design; Marco Benevento, Soledad Gonzalo Cogno, Pat King, and all Siegert group members for constant feedback on the project and manuscript; Lorena Pantano (PILM Bioinformatics Core) for assisting with sample-size determination for OD plasticity experiments; and Ana Morello from MIT for technical assistance with VEPs recordings. This research was supported by a DOC Fellowship from the Austrian Academy of Sciences at the Institute of Science and Technology Austria to R.S., from the European Union Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Actions program (grants 665385 to G.C.; 754411 to R.J.A.C.), the European Research Council (grant 715571 to S.S.), and the National Eye Institute of the National Institutes of Health under award numbers R01EY029245 (to M.F.B.) and R01EY023037 (diversity supplement to H.D.J-C.).","language":[{"iso":"eng"}],"type":"journal_article","publication_status":"published","article_number":"109313","status":"public","quality_controlled":"1","intvolume":"        36","file":[{"success":1,"date_created":"2021-07-19T13:32:17Z","checksum":"f056255f6d01fd9a86b5387635928173","file_size":56388540,"file_id":"9693","relation":"main_file","content_type":"application/pdf","creator":"cziletti","date_updated":"2021-07-19T13:32:17Z","file_name":"2021_CellReports_Venturino.pdf","access_level":"open_access"}],"month":"07","file_date_updated":"2021-07-19T13:32:17Z"},{"scopus_import":"1","citation":{"ista":"Bao Z, Erdös L, Schnelli K. 2021. Equipartition principle for Wigner matrices. Forum of Mathematics, Sigma. 9, e44.","apa":"Bao, Z., Erdös, L., &#38; Schnelli, K. (2021). Equipartition principle for Wigner matrices. <i>Forum of Mathematics, Sigma</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/fms.2021.38\">https://doi.org/10.1017/fms.2021.38</a>","short":"Z. Bao, L. Erdös, K. Schnelli, Forum of Mathematics, Sigma 9 (2021).","ama":"Bao Z, Erdös L, Schnelli K. Equipartition principle for Wigner matrices. <i>Forum of Mathematics, Sigma</i>. 2021;9. doi:<a href=\"https://doi.org/10.1017/fms.2021.38\">10.1017/fms.2021.38</a>","chicago":"Bao, Zhigang, László Erdös, and Kevin Schnelli. “Equipartition Principle for Wigner Matrices.” <i>Forum of Mathematics, Sigma</i>. Cambridge University Press, 2021. <a href=\"https://doi.org/10.1017/fms.2021.38\">https://doi.org/10.1017/fms.2021.38</a>.","mla":"Bao, Zhigang, et al. “Equipartition Principle for Wigner Matrices.” <i>Forum of Mathematics, Sigma</i>, vol. 9, e44, Cambridge University Press, 2021, doi:<a href=\"https://doi.org/10.1017/fms.2021.38\">10.1017/fms.2021.38</a>.","ieee":"Z. Bao, L. Erdös, and K. Schnelli, “Equipartition principle for Wigner matrices,” <i>Forum of Mathematics, Sigma</i>, vol. 9. Cambridge University Press, 2021."},"oa":1,"publication_identifier":{"eissn":["2050-5094"]},"doi":"10.1017/fms.2021.38","article_processing_charge":"No","author":[{"orcid":"0000-0003-3036-1475","full_name":"Bao, Zhigang","id":"442E6A6C-F248-11E8-B48F-1D18A9856A87","last_name":"Bao","first_name":"Zhigang"},{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","last_name":"Erdös","orcid":"0000-0001-5366-9603","full_name":"Erdös, László"},{"first_name":"Kevin","last_name":"Schnelli","id":"434AD0AE-F248-11E8-B48F-1D18A9856A87","full_name":"Schnelli, Kevin","orcid":"0000-0003-0954-3231"}],"arxiv":1,"title":"Equipartition principle for Wigner matrices","_id":"9550","has_accepted_license":"1","date_published":"2021-05-27T00:00:00Z","year":"2021","external_id":{"arxiv":["2008.07061"],"isi":["000654960800001"]},"department":[{"_id":"LaEr"}],"project":[{"name":"Random matrices, universality and disordered quantum systems","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","call_identifier":"FP7"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publisher":"Cambridge University Press","date_updated":"2026-04-07T08:36:39Z","publication":"Forum of Mathematics, Sigma","date_created":"2021-06-13T22:01:33Z","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","abstract":[{"lang":"eng","text":"We prove that the energy of any eigenvector of a sum of several independent large Wigner matrices is equally distributed among these matrices with very high precision. This shows a particularly strong microcanonical form of the equipartition principle for quantum systems whose components are modelled by Wigner matrices. "}],"isi":1,"ec_funded":1,"day":"27","ddc":["510"],"volume":9,"oa_version":"Published Version","file_date_updated":"2021-06-15T14:40:45Z","month":"05","file":[{"access_level":"open_access","file_name":"2021_ForumMath_Bao.pdf","date_updated":"2021-06-15T14:40:45Z","creator":"cziletti","content_type":"application/pdf","relation":"main_file","file_id":"9555","file_size":483458,"checksum":"47c986578de132200d41e6d391905519","success":1,"date_created":"2021-06-15T14:40:45Z"}],"intvolume":"         9","quality_controlled":"1","publication_status":"published","article_number":"e44","status":"public","type":"journal_article","language":[{"iso":"eng"}],"acknowledgement":"The first author is supported in part by Hong Kong RGC Grant GRF 16301519 and NSFC 11871425. The second author is supported in part by ERC Advanced Grant RANMAT 338804. The third author is supported in part by Swedish Research Council Grant VR-2017-05195 and the Knut and Alice Wallenberg Foundation"},{"scopus_import":"1","related_material":{"record":[{"status":"returned","id":"19591","relation":"popular_science"},{"relation":"dissertation_contains","status":"public","id":"19684"}],"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/turbulent-flow-simplified/","description":"News on IST Homepage"}]},"publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"oa":1,"citation":{"chicago":"Yalniz, Gökhan, Björn Hof, and Nazmi B Budanur. “Coarse Graining the State Space of a Turbulent Flow Using Periodic Orbits.” <i>Physical Review Letters</i>. American Physical Society, 2021. <a href=\"https://doi.org/10.1103/PhysRevLett.126.244502\">https://doi.org/10.1103/PhysRevLett.126.244502</a>.","ieee":"G. Yalniz, B. Hof, and N. B. Budanur, “Coarse graining the state space of a turbulent flow using periodic orbits,” <i>Physical Review Letters</i>, vol. 126, no. 24. American Physical Society, 2021.","mla":"Yalniz, Gökhan, et al. “Coarse Graining the State Space of a Turbulent Flow Using Periodic Orbits.” <i>Physical Review Letters</i>, vol. 126, no. 24, 244502, American Physical Society, 2021, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.126.244502\">10.1103/PhysRevLett.126.244502</a>.","apa":"Yalniz, G., Hof, B., &#38; Budanur, N. B. (2021). Coarse graining the state space of a turbulent flow using periodic orbits. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.126.244502\">https://doi.org/10.1103/PhysRevLett.126.244502</a>","short":"G. Yalniz, B. Hof, N.B. Budanur, Physical Review Letters 126 (2021).","ista":"Yalniz G, Hof B, Budanur NB. 2021. Coarse graining the state space of a turbulent flow using periodic orbits. Physical Review Letters. 126(24), 244502.","ama":"Yalniz G, Hof B, Budanur NB. Coarse graining the state space of a turbulent flow using periodic orbits. <i>Physical Review Letters</i>. 2021;126(24). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.126.244502\">10.1103/PhysRevLett.126.244502</a>"},"doi":"10.1103/PhysRevLett.126.244502","title":"Coarse graining the state space of a turbulent flow using periodic orbits","article_processing_charge":"No","author":[{"first_name":"Gökhan","last_name":"Yalniz","id":"66E74FA2-D8BF-11E9-8249-8DE2E5697425","full_name":"Yalniz, Gökhan","orcid":"0000-0002-8490-9312"},{"orcid":"0000-0003-2057-2754","full_name":"Hof, Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","first_name":"Björn","last_name":"Hof"},{"id":"3EA1010E-F248-11E8-B48F-1D18A9856A87","last_name":"Budanur","first_name":"Nazmi B","orcid":"0000-0003-0423-5010","full_name":"Budanur, Nazmi B"}],"arxiv":1,"_id":"9558","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2021-06-18T00:00:00Z","department":[{"_id":"GradSch"},{"_id":"BjHo"}],"year":"2021","external_id":{"isi":["000663310100008"],"arxiv":["2007.02584"]},"project":[{"_id":"238598C6-32DE-11EA-91FC-C7463DDC885E","grant_number":"662960","name":"Revisiting the Turbulence Problem Using Statistical Mechanics"}],"corr_author":"1","acknowledged_ssus":[{"_id":"ScienComp"}],"publisher":"American Physical Society","date_updated":"2026-04-07T11:47:05Z","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2007.02584"}],"date_created":"2021-06-16T15:45:36Z","publication":"Physical Review Letters","issue":"24","abstract":[{"text":"We show that turbulent dynamics that arise in simulations of the three-dimensional Navier--Stokes equations in a triply-periodic domain under sinusoidal forcing can be described as transient visits to the neighborhoods of unstable time-periodic solutions. Based on this description, we reduce the original system with more than 10^5 degrees of freedom to a 17-node Markov chain where each node corresponds to the neighborhood of a periodic orbit. The model accurately reproduces long-term averages of the system's observables as weighted sums over the periodic orbits.\r\n","lang":"eng"}],"article_type":"letter_note","day":"18","volume":126,"oa_version":"Preprint","isi":1,"month":"06","intvolume":"       126","article_number":"244502","publication_status":"published","status":"public","quality_controlled":"1","acknowledgement":"We thank the referees for improving this Letter with their comments. We acknowledge stimulating discussions with\r\nH. Edelsbrunner. This work was supported by Grant No. 662960 from the Simons Foundation (B. H.). The numerical calculations were performed at TUBITAK ULAKBIM High Performance and Grid Computing Center (TRUBA resources) and IST Austria High Performance Computing cluster.","type":"journal_article","language":[{"iso":"eng"}]},{"publisher":"American Physical Society","date_updated":"2026-04-07T11:48:53Z","_id":"9903","has_accepted_license":"1","date_published":"2021-08-06T00:00:00Z","external_id":{"isi":["000684276000002"],"arxiv":["2102.13633"]},"project":[{"call_identifier":"H2020","_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","grant_number":"850899","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control"}],"year":"2021","department":[{"_id":"MaSe"},{"_id":"GradSch"},{"_id":"MiLe"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1103/physrevlett.127.060602","article_processing_charge":"Yes (in subscription journal)","arxiv":1,"author":[{"id":"D7C012AE-D7ED-11E9-95E8-1EC5E5697425","first_name":"Volker","last_name":"Karle","orcid":"0000-0002-6963-0129","full_name":"Karle, Volker"},{"full_name":"Serbyn, Maksym","orcid":"0000-0002-2399-5827","last_name":"Serbyn","first_name":"Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Michailidis, Alexios","orcid":"0000-0002-8443-1064","first_name":"Alexios","last_name":"Michailidis","id":"36EBAD38-F248-11E8-B48F-1D18A9856A87"}],"title":"Area-law entangled eigenstates from nullspaces of local Hamiltonians","scopus_import":"1","related_material":{"record":[{"status":"public","id":"19393","relation":"dissertation_contains"}]},"citation":{"ieee":"V. Karle, M. Serbyn, and A. Michailidis, “Area-law entangled eigenstates from nullspaces of local Hamiltonians,” <i>Physical Review Letters</i>, vol. 127, no. 6. American Physical Society, 2021.","mla":"Karle, Volker, et al. “Area-Law Entangled Eigenstates from Nullspaces of Local Hamiltonians.” <i>Physical Review Letters</i>, vol. 127, no. 6, 060602, American Physical Society, 2021, doi:<a href=\"https://doi.org/10.1103/physrevlett.127.060602\">10.1103/physrevlett.127.060602</a>.","chicago":"Karle, Volker, Maksym Serbyn, and Alexios Michailidis. “Area-Law Entangled Eigenstates from Nullspaces of Local Hamiltonians.” <i>Physical Review Letters</i>. American Physical Society, 2021. <a href=\"https://doi.org/10.1103/physrevlett.127.060602\">https://doi.org/10.1103/physrevlett.127.060602</a>.","ama":"Karle V, Serbyn M, Michailidis A. Area-law entangled eigenstates from nullspaces of local Hamiltonians. <i>Physical Review Letters</i>. 2021;127(6). doi:<a href=\"https://doi.org/10.1103/physrevlett.127.060602\">10.1103/physrevlett.127.060602</a>","short":"V. Karle, M. Serbyn, A. Michailidis, Physical Review Letters 127 (2021).","apa":"Karle, V., Serbyn, M., &#38; Michailidis, A. (2021). Area-law entangled eigenstates from nullspaces of local Hamiltonians. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.127.060602\">https://doi.org/10.1103/physrevlett.127.060602</a>","ista":"Karle V, Serbyn M, Michailidis A. 2021. Area-law entangled eigenstates from nullspaces of local Hamiltonians. Physical Review Letters. 127(6), 060602."},"publication_identifier":{"eissn":["1079-7114"],"issn":["0031-9007"]},"oa":1,"quality_controlled":"1","publication_status":"published","article_number":"060602","status":"public","type":"journal_article","language":[{"iso":"eng"}],"acknowledgement":"We acknowledge useful discussions with V. Gritsev and A. Garkun and suggestions on implementation of the\r\nPPXPP model by D. Bluvstein. A. M. and M. S. were supported by the European Research Council (ERC) under\r\nthe European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899)","file_date_updated":"2021-08-13T09:28:08Z","month":"08","file":[{"access_level":"open_access","creator":"mserbyn","date_updated":"2021-08-13T09:28:08Z","file_name":"PhysRevLett.127.060602_SOM.pdf","content_type":"application/pdf","date_created":"2021-08-13T09:28:08Z","success":1,"checksum":"51218f302dcef99d90d1209809fcc874","file_size":5064231,"file_id":"9904","relation":"main_file"}],"intvolume":"       127","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"letter_note","abstract":[{"lang":"eng","text":"Eigenstate thermalization in quantum many-body systems implies that eigenstates at high energy are similar to random vectors. Identifying systems where at least some eigenstates are nonthermal is an outstanding question. In this Letter we show that interacting quantum models that have a nullspace—a degenerate subspace of eigenstates at zero energy (zero modes), which corresponds to infinite temperature, provide a route to nonthermal eigenstates. We analytically show the existence of a zero mode which can be represented as a matrix product state for a certain class of local Hamiltonians. In the more general case we use a subspace disentangling algorithm to generate an orthogonal basis of zero modes characterized by increasing entanglement entropy. We show evidence for an area-law entanglement scaling of the least-entangled zero mode in the broad parameter regime, leading to a conjecture that all local Hamiltonians with the nullspace feature zero modes with area-law entanglement scaling and, as such, break the strong thermalization hypothesis. Finally, we find zero modes in constrained models and propose a setup for observing their experimental signatures."}],"issue":"6","ec_funded":1,"isi":1,"day":"06","ddc":["539"],"oa_version":"Published Version","volume":127,"date_created":"2021-08-13T09:27:39Z","publication":"Physical Review Letters"},{"publication":"Proceedings of the 36th Annual ACM/IEEE Symposium on Logic in Computer Science","date_created":"2021-04-30T17:30:47Z","abstract":[{"lang":"eng","text":"In runtime verification, a monitor watches a trace of a system and, if possible, decides after observing each finite prefix whether or not the unknown infinite trace satisfies a given specification. We generalize the theory of runtime verification to monitors that attempt to estimate numerical values of quantitative trace properties (instead of attempting to conclude boolean values of trace specifications), such as maximal or average response time along a trace. Quantitative monitors are approximate: with every finite prefix, they can improve their estimate of the infinite trace's unknown property value. Consequently, quantitative monitors can be compared with regard to a precision-cost trade-off: better approximations of the property value require more monitor resources, such as states (in the case of finite-state monitors) or registers, and additional resources yield better approximations. We introduce a formal framework for quantitative and approximate monitoring, show how it conservatively generalizes the classical boolean setting for monitoring, and give several precision-cost trade-offs for monitors. For example, we prove that there are quantitative properties for which every additional register improves monitoring precision."}],"oa_version":"Published Version","day":"29","ddc":["000"],"isi":1,"month":"06","file_date_updated":"2021-06-16T08:23:54Z","file":[{"content_type":"application/pdf","file_id":"9557","relation":"main_file","date_created":"2021-06-16T08:23:54Z","success":1,"checksum":"6e4cba3f72775f479c5b1b75d1a4a0c4","file_size":641990,"access_level":"open_access","file_name":"qam.pdf","creator":"esarac","date_updated":"2021-06-16T08:23:54Z"}],"status":"public","article_number":"9470547","publication_status":"published","quality_controlled":"1","acknowledgement":"We thank the anonymous reviewers for their helpful comments. This research was supported in part by the Austrian Science Fund (FWF) under grant Z211-N23 (Wittgenstein Award).","type":"conference","language":[{"iso":"eng"}],"scopus_import":"1","related_material":{"record":[{"status":"public","id":"20147","relation":"dissertation_contains"}]},"oa":1,"conference":{"end_date":"2021-07-02","start_date":"2021-06-29","location":"Online","name":"LICS: Logic in Computer Science"},"citation":{"chicago":"Henzinger, Thomas A, and Naci E Sarac. “Quantitative and Approximate Monitoring.” In <i>Proceedings of the 36th Annual ACM/IEEE Symposium on Logic in Computer Science</i>. Institute of Electrical and Electronics Engineers, 2021. <a href=\"https://doi.org/10.1109/LICS52264.2021.9470547\">https://doi.org/10.1109/LICS52264.2021.9470547</a>.","ieee":"T. A. Henzinger and N. E. Sarac, “Quantitative and approximate monitoring,” in <i>Proceedings of the 36th Annual ACM/IEEE Symposium on Logic in Computer Science</i>, Online, 2021.","mla":"Henzinger, Thomas A., and Naci E. Sarac. “Quantitative and Approximate Monitoring.” <i>Proceedings of the 36th Annual ACM/IEEE Symposium on Logic in Computer Science</i>, 9470547, Institute of Electrical and Electronics Engineers, 2021, doi:<a href=\"https://doi.org/10.1109/LICS52264.2021.9470547\">10.1109/LICS52264.2021.9470547</a>.","apa":"Henzinger, T. A., &#38; Sarac, N. E. (2021). Quantitative and approximate monitoring. In <i>Proceedings of the 36th Annual ACM/IEEE Symposium on Logic in Computer Science</i>. Online: Institute of Electrical and Electronics Engineers. <a href=\"https://doi.org/10.1109/LICS52264.2021.9470547\">https://doi.org/10.1109/LICS52264.2021.9470547</a>","short":"T.A. Henzinger, N.E. Sarac, in:, Proceedings of the 36th Annual ACM/IEEE Symposium on Logic in Computer Science, Institute of Electrical and Electronics Engineers, 2021.","ista":"Henzinger TA, Sarac NE. 2021. Quantitative and approximate monitoring. Proceedings of the 36th Annual ACM/IEEE Symposium on Logic in Computer Science. LICS: Logic in Computer Science, 9470547.","ama":"Henzinger TA, Sarac NE. Quantitative and approximate monitoring. In: <i>Proceedings of the 36th Annual ACM/IEEE Symposium on Logic in Computer Science</i>. Institute of Electrical and Electronics Engineers; 2021. doi:<a href=\"https://doi.org/10.1109/LICS52264.2021.9470547\">10.1109/LICS52264.2021.9470547</a>"},"doi":"10.1109/LICS52264.2021.9470547","title":"Quantitative and approximate monitoring","arxiv":1,"article_processing_charge":"No","author":[{"first_name":"Thomas A","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","orcid":"0000-0002-2985-7724"},{"full_name":"Sarac, Naci E","last_name":"Sarac","first_name":"Naci E","id":"8C6B42F8-C8E6-11E9-A03A-F2DCE5697425"}],"has_accepted_license":"1","_id":"9356","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["2105.08353"],"isi":["000947350400021"]},"year":"2021","project":[{"call_identifier":"FWF","grant_number":"Z211","_id":"25F42A32-B435-11E9-9278-68D0E5697425","name":"Formal methods for the design and analysis of complex systems"}],"department":[{"_id":"GradSch"},{"_id":"ToHe"}],"date_published":"2021-06-29T00:00:00Z","publisher":"Institute of Electrical and Electronics Engineers","date_updated":"2026-04-07T12:02:57Z"},{"publisher":"Springer Nature","date_updated":"2026-04-07T12:34:57Z","_id":"9905","has_accepted_license":"1","project":[{"_id":"26580278-B435-11E9-9278-68D0E5697425","grant_number":"771209","call_identifier":"H2020","name":"Characterizing the fitness landscape on population and global scales"}],"year":"2021","department":[{"_id":"FyKo"}],"external_id":{"pmid":["34330988"],"isi":["000683329100001"]},"date_published":"2021-07-30T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","pmid":1,"doi":"10.1038/s41598-021-95025-3","article_processing_charge":"Yes","author":[{"last_name":"Rella","first_name":"Simon","id":"B4765ACA-AA38-11E9-AC9A-0930E6697425","full_name":"Rella, Simon"},{"last_name":"Kulikova","first_name":"Yuliya A.","full_name":"Kulikova, Yuliya A."},{"last_name":"Dermitzakis","first_name":"Emmanouil T.","full_name":"Dermitzakis, Emmanouil T."},{"full_name":"Kondrashov, Fyodor","orcid":"0000-0001-8243-4694","first_name":"Fyodor","last_name":"Kondrashov","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87"}],"title":"Rates of SARS-CoV-2 transmission and vaccination impact the fate of vaccine-resistant strains","scopus_import":"1","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"20811"}],"link":[{"relation":"press_release","description":"News on IST Website","url":"https://ist.ac.at/en/news/counterintuitive-dynamics-threaten-the-end-of-the-pandemic/"}]},"citation":{"chicago":"Rella, Simon, Yuliya A. Kulikova, Emmanouil T. Dermitzakis, and Fyodor Kondrashov. “Rates of SARS-CoV-2 Transmission and Vaccination Impact the Fate of Vaccine-Resistant Strains.” <i>Scientific Reports</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41598-021-95025-3\">https://doi.org/10.1038/s41598-021-95025-3</a>.","mla":"Rella, Simon, et al. “Rates of SARS-CoV-2 Transmission and Vaccination Impact the Fate of Vaccine-Resistant Strains.” <i>Scientific Reports</i>, vol. 11, no. 1, 15729, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41598-021-95025-3\">10.1038/s41598-021-95025-3</a>.","ieee":"S. Rella, Y. A. Kulikova, E. T. Dermitzakis, and F. Kondrashov, “Rates of SARS-CoV-2 transmission and vaccination impact the fate of vaccine-resistant strains,” <i>Scientific Reports</i>, vol. 11, no. 1. Springer Nature, 2021.","ista":"Rella S, Kulikova YA, Dermitzakis ET, Kondrashov F. 2021. Rates of SARS-CoV-2 transmission and vaccination impact the fate of vaccine-resistant strains. Scientific Reports. 11(1), 15729.","apa":"Rella, S., Kulikova, Y. A., Dermitzakis, E. T., &#38; Kondrashov, F. (2021). Rates of SARS-CoV-2 transmission and vaccination impact the fate of vaccine-resistant strains. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-021-95025-3\">https://doi.org/10.1038/s41598-021-95025-3</a>","short":"S. Rella, Y.A. Kulikova, E.T. Dermitzakis, F. Kondrashov, Scientific Reports 11 (2021).","ama":"Rella S, Kulikova YA, Dermitzakis ET, Kondrashov F. Rates of SARS-CoV-2 transmission and vaccination impact the fate of vaccine-resistant strains. <i>Scientific Reports</i>. 2021;11(1). doi:<a href=\"https://doi.org/10.1038/s41598-021-95025-3\">10.1038/s41598-021-95025-3</a>"},"oa":1,"publication_identifier":{"eissn":["2045-2322"]},"quality_controlled":"1","status":"public","publication_status":"published","article_number":"15729","language":[{"iso":"eng"}],"type":"journal_article","acknowledgement":"We thank Alexey Kondrashov, Nick Machnik, Raimundo Julian Saona Urmeneta, Gasper Tkacik and Nick Barton for fruitful discussions. We also thank participants of EvoLunch seminar at IST Austria and the internal seminar at the Banco de España for useful comments. The opinions expressed in this document are exclusively of the authors and, therefore, do not necessarily coincide with those of the Banco de España or the Eurosystem. ETD is supported by the Swiss National Science and Louis Jeantet Foundation. The work of FAK was in part supported by the ERC Consolidator Grant (771209-CharFL).","file_date_updated":"2021-08-16T11:36:49Z","month":"07","file":[{"content_type":"application/pdf","file_id":"9927","relation":"main_file","checksum":"ac86892ed17e6724c7251844da5cef5c","file_size":3432001,"date_created":"2021-08-16T11:36:49Z","success":1,"access_level":"open_access","file_name":"2021_ScientificReports_Rella.pdf","date_updated":"2021-08-16T11:36:49Z","creator":"asandaue"}],"intvolume":"        11","article_type":"original","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"issue":"1","abstract":[{"lang":"eng","text":"Vaccines are thought to be the best available solution for controlling the ongoing SARS-CoV-2 pandemic. However, the emergence of vaccine-resistant strains may come too rapidly for current vaccine developments to alleviate the health, economic and social consequences of the pandemic. To quantify and characterize the risk of such a scenario, we created a SIR-derived model with initial stochastic dynamics of the vaccine-resistant strain to study the probability of its emergence and establishment. Using parameters realistically resembling SARS-CoV-2 transmission, we model a wave-like pattern of the pandemic and consider the impact of the rate of vaccination and the strength of non-pharmaceutical intervention measures on the probability of emergence of a resistant strain. As expected, we found that a fast rate of vaccination decreases the probability of emergence of a resistant strain. Counterintuitively, when a relaxation of non-pharmaceutical interventions happened at a time when most individuals of the population have already been vaccinated the probability of emergence of a resistant strain was greatly increased. Consequently, we show that a period of transmission reduction close to the end of the vaccination campaign can substantially reduce the probability of resistant strain establishment. Our results suggest that policymakers and individuals should consider maintaining non-pharmaceutical interventions and transmission-reducing behaviours throughout the entire vaccination period."}],"ec_funded":1,"isi":1,"volume":11,"oa_version":"Published Version","day":"30","ddc":["570","610"],"date_created":"2021-08-15T22:01:26Z","publication":"Scientific Reports"},{"citation":{"mla":"Medina Ramos, Raimel A., et al. “Entanglement Transitions from Restricted Boltzmann Machines.” <i>Physical Review B</i>, vol. 104, no. 10, 104205, American Physical Society, 2021, doi:<a href=\"https://doi.org/10.1103/physrevb.104.104205\">10.1103/physrevb.104.104205</a>.","ieee":"R. A. Medina Ramos, R. Vasseur, and M. Serbyn, “Entanglement transitions from restricted Boltzmann machines,” <i>Physical Review B</i>, vol. 104, no. 10. American Physical Society, 2021.","chicago":"Medina Ramos, Raimel A, Romain Vasseur, and Maksym Serbyn. “Entanglement Transitions from Restricted Boltzmann Machines.” <i>Physical Review B</i>. American Physical Society, 2021. <a href=\"https://doi.org/10.1103/physrevb.104.104205\">https://doi.org/10.1103/physrevb.104.104205</a>.","ama":"Medina Ramos RA, Vasseur R, Serbyn M. Entanglement transitions from restricted Boltzmann machines. <i>Physical Review B</i>. 2021;104(10). doi:<a href=\"https://doi.org/10.1103/physrevb.104.104205\">10.1103/physrevb.104.104205</a>","ista":"Medina Ramos RA, Vasseur R, Serbyn M. 2021. Entanglement transitions from restricted Boltzmann machines. Physical Review B. 104(10), 104205.","short":"R.A. Medina Ramos, R. Vasseur, M. Serbyn, Physical Review B 104 (2021).","apa":"Medina Ramos, R. A., Vasseur, R., &#38; Serbyn, M. (2021). Entanglement transitions from restricted Boltzmann machines. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevb.104.104205\">https://doi.org/10.1103/physrevb.104.104205</a>"},"oa":1,"publication_identifier":{"eissn":["2469-9969"],"issn":["2469-9950"]},"related_material":{"record":[{"relation":"dissertation_contains","id":"17208","status":"public"}]},"scopus_import":"1","author":[{"orcid":"0000-0002-5383-2869","full_name":"Medina Ramos, Raimel A","id":"CE680B90-D85A-11E9-B684-C920E6697425","first_name":"Raimel A","last_name":"Medina Ramos"},{"last_name":"Vasseur","first_name":"Romain","full_name":"Vasseur, Romain"},{"full_name":"Serbyn, Maksym","orcid":"0000-0002-2399-5827","first_name":"Maksym","last_name":"Serbyn","id":"47809E7E-F248-11E8-B48F-1D18A9856A87"}],"article_processing_charge":"No","arxiv":1,"title":"Entanglement transitions from restricted Boltzmann machines","doi":"10.1103/physrevb.104.104205","date_published":"2021-09-30T00:00:00Z","department":[{"_id":"MaSe"}],"project":[{"grant_number":"850899","_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","call_identifier":"H2020","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control"}],"year":"2021","external_id":{"isi":["000704414400002"],"arxiv":["2107.05735"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"10067","date_updated":"2026-04-07T12:43:22Z","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2107.05735"}],"publisher":"American Physical Society","corr_author":"1","publication":"Physical Review B","date_created":"2021-10-02T09:03:42Z","isi":1,"ec_funded":1,"day":"30","oa_version":"Preprint","volume":104,"article_type":"original","abstract":[{"text":"The search for novel entangled phases of matter has lead to the recent discovery of a new class of “entanglement transitions,” exemplified by random tensor networks and monitored quantum circuits. Most known examples can be understood as some classical ordering transitions in an underlying statistical mechanics model, where entanglement maps onto the free-energy cost of inserting a domain wall. In this paper we study the possibility of entanglement transitions driven by physics beyond such statistical mechanics mappings. Motivated by recent applications of neural-network-inspired variational Ansätze, we investigate under what conditions on the variational parameters these Ansätze can capture an entanglement transition. We study the entanglement scaling of short-range restricted Boltzmann machine (RBM) quantum states with random phases. For uncorrelated random phases, we analytically demonstrate the absence of an entanglement transition and reveal subtle finite-size effects in finite-size numerical simulations. Introducing phases with correlations decaying as 1/r^α in real space, we observe three regions with a different scaling of entanglement entropy depending on the exponent α. We study the nature of the transition between these regions, finding numerical evidence for critical behavior. Our work establishes the presence of long-range correlated phases in RBM-based wave functions as a required ingredient for entanglement transitions.","lang":"eng"}],"issue":"10","intvolume":"       104","month":"09","language":[{"iso":"eng"}],"type":"journal_article","acknowledgement":"We would like to thank S. De Nicola, P. Brighi, and V. Karle for fruitful discussions and valuable feedback on the manuscript. R.M. and M.S. acknowledge support by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (Grant Agreement No. 850899). R.V. acknowledges support from the US Department of Energy, Office of Science, Basic Energy Sciences, under Early Career Award No. DE-SC0019168, and the Alfred P. Sloan Foundation through a Sloan Research Fellowship.","quality_controlled":"1","article_number":"104205","publication_status":"published","status":"public"}]