[{"language":[{"iso":"eng"}],"isi":1,"abstract":[{"text":"Selection accumulates information in the genome—it guides stochastically evolving populations toward states (genotype frequencies) that would be unlikely under neutrality. This can be quantified as the Kullback–Leibler (KL) divergence between the actual distribution of genotype frequencies and the corresponding neutral distribution. First, we show that this population-level information sets an upper bound on the information at the level of genotype and phenotype, limiting how precisely they can be specified by selection. Next, we study how the accumulation and maintenance of information is limited by the cost of selection, measured as the genetic load or the relative fitness variance, both of which we connect to the control-theoretic KL cost of control. The information accumulation rate is upper bounded by the population size times the cost of selection. This bound is very general, and applies across models (Wright–Fisher, Moran, diffusion) and to arbitrary forms of selection, mutation, and recombination. Finally, the cost of maintaining information depends on how it is encoded: Specifying a single allele out of two is expensive, but one bit encoded among many weakly specified loci (as in a polygenic trait) is cheap.","lang":"eng"}],"doi":"10.1073/pnas.2123152119","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"volume":119,"ddc":["570"],"fulldoi":"https://doi.org/10.1073/pnas.2123152119","related_material":{"record":[{"relation":"dissertation_contains","id":"15020","status":"public"}]},"acknowledgement":"We thank Ksenia Khudiakova, Wiktor Młynarski, Sean Stankowski, and two anonymous reviewers for discussions and comments on the manuscript. G.T. and M.H. acknowledge funding from the Human Frontier Science Program Grant RGP0032/2018. N.B. acknowledges funding from ERC Grant 250152 “Information and Evolution.”","intvolume":"       119","issue":"36","citation":{"ista":"Hledik M, Barton NH, Tkačik G. 2022. Accumulation and maintenance of information in evolution. Proceedings of the National Academy of Sciences of the United States of America. 119(36), e2123152119.","apa":"Hledik, M., Barton, N. H., &#38; Tkačik, G. (2022). Accumulation and maintenance of information in evolution. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2123152119\">https://doi.org/10.1073/pnas.2123152119</a>","ama":"Hledik M, Barton NH, Tkačik G. Accumulation and maintenance of information in evolution. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2022;119(36). doi:<a href=\"https://doi.org/10.1073/pnas.2123152119\">10.1073/pnas.2123152119</a>","chicago":"Hledik, Michal, Nicholas H Barton, and Gašper Tkačik. “Accumulation and Maintenance of Information in Evolution.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2022. <a href=\"https://doi.org/10.1073/pnas.2123152119\">https://doi.org/10.1073/pnas.2123152119</a>.","short":"M. Hledik, N.H. Barton, G. Tkačik, Proceedings of the National Academy of Sciences of the United States of America 119 (2022).","ieee":"M. Hledik, N. H. Barton, and G. Tkačik, “Accumulation and maintenance of information in evolution,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 119, no. 36. National Academy of Sciences, 2022.","mla":"Hledik, Michal, et al. “Accumulation and Maintenance of Information in Evolution.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 119, no. 36, e2123152119, National Academy of Sciences, 2022, doi:<a href=\"https://doi.org/10.1073/pnas.2123152119\">10.1073/pnas.2123152119</a>."},"day":"29","external_id":{"pmid":["36037343"],"isi":["000889278400014"]},"oa_version":"Published Version","status":"public","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"_id":"12081","ec_funded":1,"file":[{"success":1,"file_id":"12091","date_updated":"2022-09-12T08:08:12Z","file_size":2165752,"date_created":"2022-09-12T08:08:12Z","content_type":"application/pdf","access_level":"open_access","checksum":"6dec51f6567da9039982a571508a8e4d","relation":"main_file","file_name":"2022_PNAS_Hledik.pdf","creator":"dernst"}],"publication":"Proceedings of the National Academy of Sciences of the United States of America","author":[{"id":"4171253A-F248-11E8-B48F-1D18A9856A87","full_name":"Hledik, Michal","last_name":"Hledik","first_name":"Michal"},{"last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"},{"full_name":"Tkačik, Gašper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","first_name":"Gašper","last_name":"Tkačik","orcid":"1"}],"date_published":"2022-08-29T00:00:00Z","article_processing_charge":"No","month":"08","date_updated":"2026-10-02T11:40:30Z","date_created":"2022-09-11T22:01:55Z","article_type":"original","title":"Accumulation and maintenance of information in evolution","article_number":"e2123152119","quality_controlled":"1","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2022-09-12T08:08:12Z","publisher":"National Academy of Sciences","publication_status":"published","department":[{"_id":"NiBa"},{"_id":"GaTk"}],"project":[{"grant_number":"250152","_id":"25B07788-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation"},{"_id":"2665AAFE-B435-11E9-9278-68D0E5697425","grant_number":"RGP0034/2018","name":"Can evolution minimize spurious signaling crosstalk to reach optimal performance?"}],"scopus_import":"1","type":"journal_article","year":"2022","corr_author":"1","pmid":1},{"supplementarymaterial":"no","_id":"11438","author":[{"id":"3A4FAA92-F248-11E8-B48F-1D18A9856A87","full_name":"Li, Vyacheslav","last_name":"Li","first_name":"Vyacheslav"},{"first_name":"Fritz R","orcid":"0000-0002-4947-8924","last_name":"Diorico","full_name":"Diorico, Fritz R","id":"2E054C4C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hosten, Onur","id":"4C02D85E-F248-11E8-B48F-1D18A9856A87","first_name":"Onur","last_name":"Hosten","orcid":"0000-0002-2031-204X"}],"date_published":"2022-05-19T00:00:00Z","publication":"Physical Review Applied","date_updated":"2026-10-02T11:41:41Z","month":"05","researchdata_availability":"no","article_processing_charge":"No","title":"Laser frequency-offset locking at 10-Hz-level instability using hybrid electronic filters","article_type":"original","arxiv":1,"date_created":"2022-06-07T08:07:59Z","article_number":"054031","quality_controlled":"1","oa":1,"publisher":"American Physical Society","publication_status":"published","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","year":"2022","scopus_import":"1","type":"journal_article","corr_author":"1","department":[{"_id":"GradSch"},{"_id":"OnHo"}],"isi":1,"abstract":[{"lang":"eng","text":"Lasers with well-controlled relative frequencies are indispensable for many applications in science and technology. We present a frequency-offset locking method for lasers based on beat-frequency discrimination utilizing hybrid electronic LC filters. The method is specifically designed for decoupling the tightness of the lock from the broadness of its capture range. The presented demonstration locks two free-running diode lasers at 780 nm with a 5.5-GHz offset. It displays an offset frequency instability below 55 Hz for time scales in excess of 1000 s and a minimum of 12 Hz at 10-s averaging. The performance is complemented with a 190-MHz lock-capture range, a tuning range of up to 1 GHz, and a frequency ramp agility of 200kHz/μs."}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2331-7019"]},"doi":"10.1103/physrevapplied.17.054031","volume":17,"das_tickbox":"0","acknowledgement":"This work was supported by IST Austria. The authors thank Yueheng Shi for technical contributions.","intvolume":"        17","fulldoi":"https://doi.org/10.1103/physrevapplied.17.054031","related_material":{"record":[{"id":"17225","relation":"dissertation_contains","status":"public"}]},"citation":{"mla":"Li, Vyacheslav, et al. “Laser Frequency-Offset Locking at 10-Hz-Level Instability Using Hybrid Electronic Filters.” <i>Physical Review Applied</i>, vol. 17, no. 5, 054031, American Physical Society, 2022, doi:<a href=\"https://doi.org/10.1103/physrevapplied.17.054031\">10.1103/physrevapplied.17.054031</a>.","ieee":"V. Li, F. R. Diorico, and O. Hosten, “Laser frequency-offset locking at 10-Hz-level instability using hybrid electronic filters,” <i>Physical Review Applied</i>, vol. 17, no. 5. American Physical Society, 2022.","ama":"Li V, Diorico FR, Hosten O. Laser frequency-offset locking at 10-Hz-level instability using hybrid electronic filters. <i>Physical Review Applied</i>. 2022;17(5). doi:<a href=\"https://doi.org/10.1103/physrevapplied.17.054031\">10.1103/physrevapplied.17.054031</a>","chicago":"Li, Vyacheslav, Fritz R Diorico, and Onur Hosten. “Laser Frequency-Offset Locking at 10-Hz-Level Instability Using Hybrid Electronic Filters.” <i>Physical Review Applied</i>. American Physical Society, 2022. <a href=\"https://doi.org/10.1103/physrevapplied.17.054031\">https://doi.org/10.1103/physrevapplied.17.054031</a>.","short":"V. Li, F.R. Diorico, O. Hosten, Physical Review Applied 17 (2022).","apa":"Li, V., Diorico, F. R., &#38; Hosten, O. (2022). Laser frequency-offset locking at 10-Hz-level instability using hybrid electronic filters. <i>Physical Review Applied</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevapplied.17.054031\">https://doi.org/10.1103/physrevapplied.17.054031</a>","ista":"Li V, Diorico FR, Hosten O. 2022. Laser frequency-offset locking at 10-Hz-level instability using hybrid electronic filters. Physical Review Applied. 17(5), 054031."},"issue":"5","external_id":{"isi":["000880670300001"],"arxiv":["2111.13194"]},"keyword":["General Physics and Astronomy"],"oa_version":"Preprint","main_file_link":[{"url":" https://doi.org/10.48550/arXiv.2111.13194","open_access":"1"}],"day":"19","status":"public"},{"project":[{"grant_number":"101020331","_id":"62796744-2b32-11ec-9570-940b20777f1d","name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020"}],"department":[{"_id":"GradSch"},{"_id":"LaEr"},{"_id":"RoSe"}],"corr_author":"1","year":"2022","scopus_import":"1","type":"journal_article","file_date_updated":"2022-08-08T07:36:34Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_status":"published","publisher":"Springer Nature","oa":1,"quality_controlled":"1","article_number":"5","date_created":"2022-08-05T11:36:56Z","article_type":"original","title":"The BCS energy gap at high density","article_processing_charge":"Yes (via OA deal)","date_updated":"2026-10-02T11:43:00Z","month":"07","file":[{"creator":"dernst","file_name":"2022_JourStatisticalPhysics_Henheik.pdf","relation":"main_file","checksum":"b398c4dbf65f71d417981d6e366427e9","access_level":"open_access","content_type":"application/pdf","file_size":419563,"date_created":"2022-08-08T07:36:34Z","file_id":"11746","success":1,"date_updated":"2022-08-08T07:36:34Z"}],"publication":"Journal of Statistical Physics","date_published":"2022-07-29T00:00:00Z","author":[{"first_name":"Sven Joscha","orcid":"0000-0003-1106-327X","last_name":"Henheik","full_name":"Henheik, Sven Joscha","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb"},{"last_name":"Lauritsen","orcid":"0000-0003-4476-2288","first_name":"Asbjørn Bækgaard","id":"e1a2682f-dc8d-11ea-abe3-81da9ac728f1","full_name":"Lauritsen, Asbjørn Bækgaard"}],"ec_funded":1,"_id":"11732","status":"public","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"29","oa_version":"Published Version","external_id":{"isi":["000833007200002"]},"keyword":["Mathematical Physics","Statistical and Nonlinear Physics"],"citation":{"mla":"Henheik, Sven Joscha, and Asbjørn Bækgaard Lauritsen. “The BCS Energy Gap at High Density.” <i>Journal of Statistical Physics</i>, vol. 189, 5, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1007/s10955-022-02965-9\">10.1007/s10955-022-02965-9</a>.","ieee":"S. J. Henheik and A. B. Lauritsen, “The BCS energy gap at high density,” <i>Journal of Statistical Physics</i>, vol. 189. Springer Nature, 2022.","short":"S.J. Henheik, A.B. Lauritsen, Journal of Statistical Physics 189 (2022).","chicago":"Henheik, Sven Joscha, and Asbjørn Bækgaard Lauritsen. “The BCS Energy Gap at High Density.” <i>Journal of Statistical Physics</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s10955-022-02965-9\">https://doi.org/10.1007/s10955-022-02965-9</a>.","ama":"Henheik SJ, Lauritsen AB. The BCS energy gap at high density. <i>Journal of Statistical Physics</i>. 2022;189. doi:<a href=\"https://doi.org/10.1007/s10955-022-02965-9\">10.1007/s10955-022-02965-9</a>","apa":"Henheik, S. J., &#38; Lauritsen, A. B. (2022). The BCS energy gap at high density. <i>Journal of Statistical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10955-022-02965-9\">https://doi.org/10.1007/s10955-022-02965-9</a>","ista":"Henheik SJ, Lauritsen AB. 2022. The BCS energy gap at high density. Journal of Statistical Physics. 189, 5."},"related_material":{"record":[{"id":"19540","relation":"dissertation_contains","status":"public"},{"relation":"dissertation_contains","id":"18135","status":"public"}]},"fulldoi":"https://doi.org/10.1007/s10955-022-02965-9","intvolume":"       189","acknowledgement":"We are grateful to Robert Seiringer for helpful discussions and many valuable comments\r\non an earlier version of the manuscript. J.H. acknowledges partial financial support by the ERC Advanced Grant “RMTBeyond’ No. 101020331. Open access funding provided by Institute of Science and Technology (IST Austria)","volume":189,"ddc":["530"],"doi":"10.1007/s10955-022-02965-9","publication_identifier":{"eissn":["1572-9613"],"issn":["0022-4715"]},"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We study the BCS energy gap Ξ in the high–density limit and derive an asymptotic formula, which strongly depends on the strength of the interaction potential V on the Fermi surface. In combination with the recent result by one of us (Math. Phys. Anal. Geom. 25, 3, 2022) on the critical temperature Tc at high densities, we prove the universality of the ratio of the energy gap and the critical temperature."}],"isi":1},{"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","publication_status":"submitted","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2022-07-27T09:30:30Z","quality_controlled":"1","oa":1,"year":"2022","type":"journal_article","corr_author":"1","department":[{"_id":"GradSch"},{"_id":"HeEd"}],"project":[{"call_identifier":"H2020","name":"Alpha Shape Theory Extended","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","grant_number":"788183"},{"call_identifier":"FWF","name":"Mathematics, Computer Science","grant_number":"Z00342","_id":"268116B8-B435-11E9-9278-68D0E5697425"},{"grant_number":"I02979-N35","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Persistence and stability of geometric complexes"}],"author":[{"id":"3C2B033E-F248-11E8-B48F-1D18A9856A87","full_name":"Biswas, Ranita","last_name":"Biswas","orcid":"0000-0002-5372-7890","first_name":"Ranita"},{"first_name":"Sebastiano","orcid":"0000-0001-6249-0832","last_name":"Cultrera di Montesano","full_name":"Cultrera di Montesano, Sebastiano","id":"34D2A09C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833"},{"first_name":"Morteza","last_name":"Saghafian","full_name":"Saghafian, Morteza"}],"date_published":"2022-07-25T00:00:00Z","file":[{"date_updated":"2022-07-27T09:30:30Z","file_id":"11661","file_size":564836,"date_created":"2022-07-27T09:30:30Z","content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"95903f9d1649e8e437a967b6f2f64730","creator":"scultrer","file_name":"window 1.pdf"}],"publication":"LIPIcs","_id":"11660","ec_funded":1,"title":"A window to the persistence of 1D maps. 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Schloss Dagstuhl - Leibniz-Zentrum für Informatik.","mla":"Biswas, Ranita, et al. “A Window to the Persistence of 1D Maps. I: Geometric Characterization of Critical Point Pairs.” <i>LIPIcs</i>, Schloss Dagstuhl - Leibniz-Zentrum für Informatik.","ista":"Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. A window to the persistence of 1D maps. I: Geometric characterization of critical point pairs. LIPIcs.","apa":"Biswas, R., Cultrera di Montesano, S., Edelsbrunner, H., &#38; Saghafian, M. (n.d.). A window to the persistence of 1D maps. I: Geometric characterization of critical point pairs. <i>LIPIcs</i>. Schloss Dagstuhl - Leibniz-Zentrum für Informatik."},"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","has_accepted_license":"1","abstract":[{"text":"We characterize critical points of 1-dimensional maps paired in persistent homology geometrically and this way get elementary proofs of theorems about the symmetry of persistence diagrams and the variation of such maps. In particular, we identify branching points and endpoints of networks as the sole source of asymmetry and relate the cycle basis in persistent homology with a version of the stable marriage problem. Our analysis provides the foundations of fast algorithms for maintaining collections of interrelated sorted lists together with their persistence diagrams. ","lang":"eng"}],"language":[{"iso":"eng"}],"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme, grant no. 788183, from the Wittgenstein Prize, Austrian Science Fund (FWF), grant no. Z 342-N31, and from the DFG Collaborative Research Center TRR 109, ‘Discretization in Geometry and Dynamics’, Austrian Science Fund (FWF), grant no. I 02979-N35. ","alternative_title":["LIPIcs"],"related_material":{"record":[{"relation":"dissertation_contains","id":"15094","status":"public"},{"status":"public","id":"13182","relation":"later_version"}]},"ddc":["510"]},{"department":[{"_id":"GradSch"},{"_id":"HeEd"}],"project":[{"grant_number":"788183","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","name":"Alpha Shape Theory Extended","call_identifier":"H2020"},{"_id":"268116B8-B435-11E9-9278-68D0E5697425","grant_number":"Z00342","name":"Mathematics, Computer Science","call_identifier":"FWF"},{"_id":"2561EBF4-B435-11E9-9278-68D0E5697425","grant_number":"I02979-N35","call_identifier":"FWF","name":"Persistence and stability of geometric complexes"}],"type":"journal_article","year":"2022","corr_author":"1","oa":1,"quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2022-07-27T09:25:53Z","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","publication_status":"draft","article_processing_charge":"No","date_updated":"2026-10-02T11:55:11Z","month":"07","date_created":"2022-07-27T09:27:34Z","title":"Depth in arrangements: Dehn–Sommerville–Euler relations with applications","_id":"11658","ec_funded":1,"publication":"Leibniz International Proceedings on Mathematics","file":[{"date_created":"2022-07-27T09:25:53Z","file_size":639266,"date_updated":"2022-07-27T09:25:53Z","file_id":"11659","relation":"main_file","checksum":"b2f511e8b1cae5f1892b0cdec341acac","file_name":"D-S-E.pdf","creator":"scultrer","content_type":"application/pdf","access_level":"open_access"}],"author":[{"full_name":"Biswas, Ranita","id":"3C2B033E-F248-11E8-B48F-1D18A9856A87","first_name":"Ranita","orcid":"0000-0002-5372-7890","last_name":"Biswas"},{"last_name":"Cultrera di Montesano","orcid":"0000-0001-6249-0832","first_name":"Sebastiano","id":"34D2A09C-F248-11E8-B48F-1D18A9856A87","full_name":"Cultrera di Montesano, Sebastiano"},{"orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert"},{"id":"f86f7148-b140-11ec-9577-95435b8df824","full_name":"Saghafian, Morteza","last_name":"Saghafian","first_name":"Morteza"}],"date_published":"2022-07-27T00:00:00Z","has_accepted_license":"1","status":"public","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"ista":"Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. Depth in arrangements: Dehn–Sommerville–Euler relations with applications. Leibniz International Proceedings on Mathematics.","apa":"Biswas, R., Cultrera di Montesano, S., Edelsbrunner, H., &#38; Saghafian, M. (n.d.). Depth in arrangements: Dehn–Sommerville–Euler relations with applications. <i>Leibniz International Proceedings on Mathematics</i>. Schloss Dagstuhl - Leibniz-Zentrum für Informatik.","short":"R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, M. Saghafian, Leibniz International Proceedings on Mathematics (n.d.).","ama":"Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. Depth in arrangements: Dehn–Sommerville–Euler relations with applications. <i>Leibniz International Proceedings on Mathematics</i>.","chicago":"Biswas, Ranita, Sebastiano Cultrera di Montesano, Herbert Edelsbrunner, and Morteza Saghafian. “Depth in Arrangements: Dehn–Sommerville–Euler Relations with Applications.” <i>Leibniz International Proceedings on Mathematics</i>. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, n.d.","ieee":"R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, and M. Saghafian, “Depth in arrangements: Dehn–Sommerville–Euler relations with applications,” <i>Leibniz International Proceedings on Mathematics</i>. Schloss Dagstuhl - Leibniz-Zentrum für Informatik.","mla":"Biswas, Ranita, et al. “Depth in Arrangements: Dehn–Sommerville–Euler Relations with Applications.” <i>Leibniz International Proceedings on Mathematics</i>, Schloss Dagstuhl - Leibniz-Zentrum für Informatik."},"day":"27","oa_version":"Submitted Version","ddc":["510"],"related_material":{"record":[{"status":"public","id":"15094","relation":"dissertation_contains"},{"status":"public","id":"15380","relation":"later_version"}]},"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme, grant no. 788183, from the Wittgenstein Prize, Austrian Science Fund (FWF), grant no. Z 342-N31, and from the DFG Collaborative Research Center TRR 109, ‘Discretization in Geometry and Dynamics’, Austrian Science Fund (FWF), grant no. I 02979-N35.","language":[{"iso":"eng"}],"abstract":[{"text":"The depth of a cell in an arrangement of n (non-vertical) great-spheres in Sd is the number of great-spheres that pass above the cell. We prove Euler-type relations, which imply extensions of the classic Dehn–Sommerville relations for convex polytopes to sublevel sets of the depth function, and we use the relations to extend the expressions for the number of faces of neighborly polytopes to the number of cells of levels in neighborly arrangements.","lang":"eng"}]},{"oa_version":"Published Version","citation":{"ista":"Venkataramanan R, Kögler K, Mondelli M. 2022. Estimation in rotationally invariant generalized linear models via approximate message passing. Proceedings of the 39th International Conference on Machine Learning. ICML: International Conference on Machine Learning vol. 162, 22.","apa":"Venkataramanan, R., Kögler, K., &#38; Mondelli, M. (2022). Estimation in rotationally invariant generalized linear models via approximate message passing. In <i>Proceedings of the 39th International Conference on Machine Learning</i> (Vol. 162). Baltimore, MD, United States: ML Research Press.","ieee":"R. Venkataramanan, K. Kögler, and M. Mondelli, “Estimation in rotationally invariant generalized linear models via approximate message passing,” in <i>Proceedings of the 39th International Conference on Machine Learning</i>, Baltimore, MD, United States, 2022, vol. 162.","ama":"Venkataramanan R, Kögler K, Mondelli M. Estimation in rotationally invariant generalized linear models via approximate message passing. In: <i>Proceedings of the 39th International Conference on Machine Learning</i>. Vol 162. ML Research Press; 2022.","chicago":"Venkataramanan, Ramji, Kevin Kögler, and Marco Mondelli. “Estimation in Rotationally Invariant Generalized Linear Models via Approximate Message Passing.” In <i>Proceedings of the 39th International Conference on Machine Learning</i>, Vol. 162. ML Research Press, 2022.","short":"R. Venkataramanan, K. Kögler, M. Mondelli, in:, Proceedings of the 39th International Conference on Machine Learning, ML Research Press, 2022.","mla":"Venkataramanan, Ramji, et al. “Estimation in Rotationally Invariant Generalized Linear Models via Approximate Message Passing.” <i>Proceedings of the 39th International Conference on Machine Learning</i>, vol. 162, 22, ML Research Press, 2022."},"status":"public","has_accepted_license":"1","abstract":[{"text":"We consider the problem of signal estimation in generalized linear models defined via rotationally invariant design matrices. Since these matrices can have an arbitrary spectral distribution, this model is well suited for capturing complex correlation structures which often arise in applications. We propose a novel family of approximate message passing (AMP) algorithms for signal estimation, and rigorously characterize their performance in the high-dimensional limit via a state evolution recursion. Our rotationally invariant AMP has complexity of the same order as the existing AMP derived under the restrictive assumption of a Gaussian design; our algorithm also recovers this existing AMP as a special case. Numerical results showcase a performance close to Vector AMP (which is conjectured to be Bayes-optimal in some settings), but obtained with a much lower complexity, as the proposed algorithm does not require a computationally expensive singular value decomposition.","lang":"eng"}],"language":[{"iso":"eng"}],"acknowledgement":"The authors would like to thank the anonymous reviewers for their helpful comments. KK and MM were partially supported by the 2019 Lopez-Loreta Prize.","intvolume":"       162","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"23072"}]},"ddc":["000"],"volume":162,"publication_status":"published","publisher":"ML Research Press","file_date_updated":"2023-02-13T10:53:11Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"quality_controlled":"1","article_number":"22","corr_author":"1","year":"2022","type":"conference","project":[{"_id":"059876FA-7A3F-11EA-A408-12923DDC885E","name":"Prix Lopez-Loretta 2019 - Marco Mondelli"}],"department":[{"_id":"MaMo"}],"date_published":"2022-01-01T00:00:00Z","author":[{"full_name":"Venkataramanan, Ramji","first_name":"Ramji","last_name":"Venkataramanan"},{"full_name":"Kögler, Kevin","id":"94ec913c-dc85-11ea-9058-e5051ab2428b","first_name":"Kevin","last_name":"Kögler"},{"first_name":"Marco","orcid":"0000-0002-3242-7020","last_name":"Mondelli","full_name":"Mondelli, Marco","id":"27EB676C-8706-11E9-9510-7717E6697425"}],"file":[{"creator":"dernst","file_name":"2022_PMLR_Venkataramanan.pdf","checksum":"67436eb0a660789514cdf9db79e84683","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_size":2341343,"date_created":"2023-02-13T10:53:11Z","date_updated":"2023-02-13T10:53:11Z","file_id":"12547","success":1}],"publication":"Proceedings of the 39th International Conference on Machine Learning","conference":{"end_date":"2022-07-23","start_date":"2022-07-17","location":"Baltimore, MD, United States","name":"ICML: International Conference on Machine Learning"},"_id":"12540","title":"Estimation in rotationally invariant generalized linear models via approximate message passing","date_created":"2023-02-10T13:49:04Z","date_updated":"2026-10-12T13:04:49Z","article_processing_charge":"No"},{"_id":"23132","author":[{"full_name":"Serivichyaswat, Phanu T.","first_name":"Phanu T.","last_name":"Serivichyaswat"},{"id":"0c51b9f5-90c8-11f1-b4ef-9ad5d3d9a34a","full_name":"Bartusch, Kai","orcid":"0000-0003-2708-5545","last_name":"Bartusch","first_name":"Kai"},{"full_name":"Leso, Martina","first_name":"Martina","last_name":"Leso"},{"full_name":"Musseau, Constance","first_name":"Constance","last_name":"Musseau"},{"last_name":"Iwase","first_name":"Akira","full_name":"Iwase, Akira"},{"full_name":"Chen, Yu","last_name":"Chen","first_name":"Yu"},{"first_name":"Keiko","last_name":"Sugimoto","full_name":"Sugimoto, Keiko"},{"last_name":"Quint","first_name":"Marcel","full_name":"Quint, Marcel"},{"full_name":"Melnyk, Charles W.","last_name":"Melnyk","first_name":"Charles W."}],"date_published":"2022-03-01T00:00:00Z","publication":"Development","date_updated":"2026-10-14T12:22:27Z","month":"03","article_processing_charge":"Yes (in subscription journal)","title":"High temperature perception in leaves promotes vascular regeneration and graft formation in distant tissues","article_type":"original","date_created":"2026-10-13T11:15:22Z","article_number":"dev200079","quality_controlled":"1","OA_place":"publisher","publisher":"The Company of Biologists","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","type":"journal_article","year":"2022","OA_type":"hybrid","extern":"1","pmid":1,"abstract":[{"lang":"eng","text":"Cellular regeneration in response to wounding is fundamental to maintain tissue integrity. Various internal factors including hormones and transcription factors mediate healing, but little is known about the role of external factors. To understand how the environment affects regeneration, we investigated the effects of temperature upon the horticulturally relevant process of plant grafting. We found that elevated temperatures accelerated vascular regeneration in Arabidopsis thaliana and tomato grafts. Leaves were crucial for this effect, as blocking auxin transport or mutating PHYTOCHROME INTERACTING FACTOR 4 (PIF4) or YUCCA2/5/8/9 in the cotyledons abolished the temperature enhancement. However, these perturbations did not affect grafting at ambient temperatures, and temperature enhancement of callus formation and tissue adhesion did not require PIF4, suggesting leaf-derived auxin specifically enhanced vascular regeneration in response to elevated temperatures. We also found that elevated temperatures accelerated the formation of inter-plant vascular connections between the parasitic plant Phtheirospermum japonicum and host Arabidopsis, and this effect required shoot-derived auxin from the parasite. Taken together, our results identify a pathway whereby local temperature perception mediates long distance auxin signaling to modify regeneration, grafting and parasitism."}],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1477-9129"],"issn":["0950-1991"]},"doi":"10.1242/dev.200079","ddc":["580"],"volume":149,"intvolume":"       149","fulldoi":"https://doi.org/10.1242/dev.200079","citation":{"mla":"Serivichyaswat, Phanu T., et al. “High Temperature Perception in Leaves Promotes Vascular Regeneration and Graft Formation in Distant Tissues.” <i>Development</i>, vol. 149, no. 5, dev200079, The Company of Biologists, 2022, doi:<a href=\"https://doi.org/10.1242/dev.200079\">10.1242/dev.200079</a>.","ieee":"P. T. Serivichyaswat <i>et al.</i>, “High temperature perception in leaves promotes vascular regeneration and graft formation in distant tissues,” <i>Development</i>, vol. 149, no. 5. The Company of Biologists, 2022.","ama":"Serivichyaswat PT, Bartusch K, Leso M, et al. High temperature perception in leaves promotes vascular regeneration and graft formation in distant tissues. <i>Development</i>. 2022;149(5). doi:<a href=\"https://doi.org/10.1242/dev.200079\">10.1242/dev.200079</a>","chicago":"Serivichyaswat, Phanu T., Kai Bartusch, Martina Leso, Constance Musseau, Akira Iwase, Yu Chen, Keiko Sugimoto, Marcel Quint, and Charles W. Melnyk. “High Temperature Perception in Leaves Promotes Vascular Regeneration and Graft Formation in Distant Tissues.” <i>Development</i>. The Company of Biologists, 2022. <a href=\"https://doi.org/10.1242/dev.200079\">https://doi.org/10.1242/dev.200079</a>.","short":"P.T. Serivichyaswat, K. Bartusch, M. Leso, C. Musseau, A. Iwase, Y. Chen, K. Sugimoto, M. Quint, C.W. Melnyk, Development 149 (2022).","apa":"Serivichyaswat, P. T., Bartusch, K., Leso, M., Musseau, C., Iwase, A., Chen, Y., … Melnyk, C. W. (2022). High temperature perception in leaves promotes vascular regeneration and graft formation in distant tissues. <i>Development</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/dev.200079\">https://doi.org/10.1242/dev.200079</a>","ista":"Serivichyaswat PT, Bartusch K, Leso M, Musseau C, Iwase A, Chen Y, Sugimoto K, Quint M, Melnyk CW. 2022. High temperature perception in leaves promotes vascular regeneration and graft formation in distant tissues. Development. 149(5), dev200079."},"issue":"5","external_id":{"pmid":["35217857"]},"oa_version":"Published Version","day":"01","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","has_accepted_license":"1"},{"ec_funded":1,"_id":"14597","publication":"arXiv","date_published":"2022-03-31T00:00:00Z","author":[{"id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87","full_name":"Fischer, Julian L","orcid":"0000-0002-0479-558X","last_name":"Fischer","first_name":"Julian L"},{"full_name":"Marveggio, Alice","id":"25647992-AA84-11E9-9D75-8427E6697425","first_name":"Alice","last_name":"Marveggio"}],"article_processing_charge":"No","month":"03","date_updated":"2026-10-15T09:49:35Z","date_created":"2023-11-23T09:30:02Z","arxiv":1,"title":"Quantitative convergence of the vectorial Allen-Cahn equation towards multiphase mean curvature flow","article_number":"2203.17143","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"draft","project":[{"grant_number":"948819","_id":"0aa76401-070f-11eb-9043-b5bb049fa26d","name":"Bridging Scales in Random Materials","call_identifier":"H2020"}],"department":[{"_id":"JuFi"}],"corr_author":"1","type":"preprint","year":"2022","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Phase-field models such as the Allen-Cahn equation may give rise to the formation and evolution of geometric shapes, a phenomenon that may be analyzed rigorously in suitable scaling regimes. In its sharp-interface limit, the vectorial Allen-Cahn equation with a potential with N≥3 distinct minima has been conjectured to describe the evolution of branched interfaces by multiphase mean curvature flow.\r\nIn the present work, we give a rigorous proof for this statement in two and three ambient dimensions and for a suitable class of potentials: As long as a strong solution to multiphase mean curvature flow exists, solutions to the vectorial Allen-Cahn equation with well-prepared initial data converge towards multiphase mean curvature flow in the limit of vanishing interface width parameter ε↘0. We even establish the rate of convergence O(ε1/2).\r\nOur approach is based on the gradient flow structure of the Allen-Cahn equation and its limiting motion: Building on the recent concept of \"gradient flow calibrations\" for multiphase mean curvature flow, we introduce a notion of relative entropy for the vectorial Allen-Cahn equation with multi-well potential. This enables us to overcome the limitations of other approaches, e.g. avoiding the need for a stability analysis of the Allen-Cahn operator or additional convergence hypotheses for the energy at positive times."}],"doi":"10.48550/ARXIV.2203.17143","related_material":{"record":[{"id":"14587","relation":"dissertation_contains","status":"public"},{"id":"17481","relation":"later_version","status":"public"}]},"fulldoi":"https://doi.org/10.48550/ARXIV.2203.17143","citation":{"mla":"Fischer, Julian L., and Alice Marveggio. “Quantitative Convergence of the Vectorial Allen-Cahn Equation towards Multiphase Mean Curvature Flow.” <i>ArXiv</i>, 2203.17143, doi:<a href=\"https://doi.org/10.48550/ARXIV.2203.17143\">10.48550/ARXIV.2203.17143</a>.","ieee":"J. L. Fischer and A. Marveggio, “Quantitative convergence of the vectorial Allen-Cahn equation towards multiphase mean curvature flow,” <i>arXiv</i>. .","short":"J.L. Fischer, A. Marveggio, ArXiv (n.d.).","ama":"Fischer JL, Marveggio A. Quantitative convergence of the vectorial Allen-Cahn equation towards multiphase mean curvature flow. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/ARXIV.2203.17143\">10.48550/ARXIV.2203.17143</a>","chicago":"Fischer, Julian L, and Alice Marveggio. “Quantitative Convergence of the Vectorial Allen-Cahn Equation towards Multiphase Mean Curvature Flow.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/ARXIV.2203.17143\">https://doi.org/10.48550/ARXIV.2203.17143</a>.","apa":"Fischer, J. L., &#38; Marveggio, A. (n.d.). Quantitative convergence of the vectorial Allen-Cahn equation towards multiphase mean curvature flow. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/ARXIV.2203.17143\">https://doi.org/10.48550/ARXIV.2203.17143</a>","ista":"Fischer JL, Marveggio A. Quantitative convergence of the vectorial Allen-Cahn equation towards multiphase mean curvature flow. arXiv, 2203.17143."},"day":"31","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2203.17143"}],"oa_version":"Preprint","external_id":{"arxiv":["2203.17143"]},"status":"public"},{"date_created":"2022-06-30T16:48:00Z","title":"CoCoA: Concurrent continuous group key agreement","article_processing_charge":"No","date_updated":"2026-10-16T08:11:07Z","month":"05","publication":"Advances in Cryptology – EUROCRYPT 2022","date_published":"2022-05-25T00:00:00Z","author":[{"last_name":"Alwen","first_name":"Joël","full_name":"Alwen, Joël"},{"full_name":"Auerbach, Benedikt","id":"D33D2B18-E445-11E9-ABB7-15F4E5697425","first_name":"Benedikt","orcid":"0000-0002-7553-6606","last_name":"Auerbach"},{"full_name":"Cueto Noval, Miguel","id":"ffc563a3-f6e0-11ea-865d-e3cce03d17cc","first_name":"Miguel","last_name":"Cueto Noval","orcid":"0000-0002-2505-4246"},{"id":"3E83A2F8-F248-11E8-B48F-1D18A9856A87","full_name":"Klein, Karen","last_name":"Klein","first_name":"Karen"},{"id":"2D7ABD02-F248-11E8-B48F-1D18A9856A87","full_name":"Pascual Perez, Guillermo","orcid":"0000-0001-8630-415X","last_name":"Pascual Perez","first_name":"Guillermo"},{"last_name":"Pietrzak","orcid":"0000-0002-9139-1654","first_name":"Krzysztof Z","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","full_name":"Pietrzak, Krzysztof Z"},{"first_name":"Michael","last_name":"Walter","full_name":"Walter, Michael"}],"conference":{"end_date":"2022-06-03","start_date":"2022-05-30","location":"Trondheim, Norway","name":"EUROCRYPT: Theory and Applications of Cryptology and Information Security"},"ec_funded":1,"_id":"11476","project":[{"name":"Teaching Old Crypto New Tricks","call_identifier":"H2020","_id":"258AA5B2-B435-11E9-9278-68D0E5697425","grant_number":"682815"},{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"}],"department":[{"_id":"GradSch"},{"_id":"KrPi"}],"corr_author":"1","scopus_import":"1","year":"2022","type":"conference","page":"815–844","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","publisher":"Springer Nature","quality_controlled":"1","oa":1,"related_material":{"record":[{"id":"18088","relation":"dissertation_contains","status":"public"}]},"alternative_title":["LNCS"],"fulldoi":"https://doi.org/10.1007/978-3-031-07085-3_28","intvolume":"     13276","acknowledgement":"We thank Marta Mularczyk and Yiannis Tselekounis for their very helpful feedback on an earlier draft of this paper.","volume":13276,"doi":"10.1007/978-3-031-07085-3_28","publication_identifier":{"isbn":["9783031070846"],"eisbn":["9783031070853"],"eissn":["1611-3349"],"issn":["0302-9743"]},"language":[{"iso":"eng"}],"abstract":[{"text":"Messaging platforms like Signal are widely deployed and provide strong security in an asynchronous setting. It is a challenging problem to construct a protocol with similar security guarantees that can efficiently scale to large groups. A major bottleneck are the frequent key rotations users need to perform to achieve post compromise forward security.\r\n\r\nIn current proposals – most notably in TreeKEM (which is part of the IETF’s Messaging Layer Security (MLS) protocol draft) – for users in a group of size n to rotate their keys, they must each craft a message of size log(n) to be broadcast to the group using an (untrusted) delivery server.\r\n\r\nIn larger groups, having users sequentially rotate their keys requires too much bandwidth (or takes too long), so variants allowing any T≤n users to simultaneously rotate their keys in just 2 communication rounds have been suggested (e.g. “Propose and Commit” by MLS). Unfortunately, 2-round concurrent updates are either damaging or expensive (or both); i.e. they either result in future operations being more costly (e.g. via “blanking” or “tainting”) or are costly themselves requiring Ω(T) communication for each user [Bienstock et al., TCC’20].\r\n\r\nIn this paper we propose CoCoA; a new scheme that allows for T concurrent updates that are neither damaging nor costly. That is, they add no cost to future operations yet they only require Ω(log2(n)) communication per user. To circumvent the [Bienstock et al.] lower bound, CoCoA increases the number of rounds needed to complete all updates from 2 up to (at most) log(n); though typically fewer rounds are needed.\r\n\r\nThe key insight of our protocol is the following: in the (non-concurrent version of) TreeKEM, a delivery server which gets T concurrent update requests will approve one and reject the remaining T−1. In contrast, our server attempts to apply all of them. If more than one user requests to rotate the same key during a round, the server arbitrarily picks a winner. Surprisingly, we prove that regardless of how the server chooses the winners, all previously compromised users will recover after at most log(n) such update rounds.\r\n\r\nTo keep the communication complexity low, CoCoA is a server-aided CGKA. That is, the delivery server no longer blindly forwards packets, but instead actively computes individualized packets tailored to each user. As the server is untrusted, this change requires us to develop new mechanisms ensuring robustness of the protocol.","lang":"eng"}],"isi":1,"place":"Cham","status":"public","day":"25","main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2022/251"}],"oa_version":"Preprint","external_id":{"isi":["000832305300028"]},"citation":{"ieee":"J. Alwen <i>et al.</i>, “CoCoA: Concurrent continuous group key agreement,” in <i>Advances in Cryptology – EUROCRYPT 2022</i>, Trondheim, Norway, 2022, vol. 13276, pp. 815–844.","short":"J. Alwen, B. Auerbach, M. Cueto Noval, K. Klein, G. Pascual Perez, K.Z. Pietrzak, M. Walter, in:, Advances in Cryptology – EUROCRYPT 2022, Springer Nature, Cham, 2022, pp. 815–844.","ama":"Alwen J, Auerbach B, Cueto Noval M, et al. CoCoA: Concurrent continuous group key agreement. In: <i>Advances in Cryptology – EUROCRYPT 2022</i>. Vol 13276. Cham: Springer Nature; 2022:815–844. doi:<a href=\"https://doi.org/10.1007/978-3-031-07085-3_28\">10.1007/978-3-031-07085-3_28</a>","chicago":"Alwen, Joël, Benedikt Auerbach, Miguel Cueto Noval, Karen Klein, Guillermo Pascual Perez, Krzysztof Z Pietrzak, and Michael Walter. “CoCoA: Concurrent Continuous Group Key Agreement.” In <i>Advances in Cryptology – EUROCRYPT 2022</i>, 13276:815–844. Cham: Springer Nature, 2022. <a href=\"https://doi.org/10.1007/978-3-031-07085-3_28\">https://doi.org/10.1007/978-3-031-07085-3_28</a>.","mla":"Alwen, Joël, et al. “CoCoA: Concurrent Continuous Group Key Agreement.” <i>Advances in Cryptology – EUROCRYPT 2022</i>, vol. 13276, Springer Nature, 2022, pp. 815–844, doi:<a href=\"https://doi.org/10.1007/978-3-031-07085-3_28\">10.1007/978-3-031-07085-3_28</a>.","ista":"Alwen J, Auerbach B, Cueto Noval M, Klein K, Pascual Perez G, Pietrzak KZ, Walter M. 2022. CoCoA: Concurrent continuous group key agreement. Advances in Cryptology – EUROCRYPT 2022. EUROCRYPT: Theory and Applications of Cryptology and Information Security, LNCS, vol. 13276, 815–844.","apa":"Alwen, J., Auerbach, B., Cueto Noval, M., Klein, K., Pascual Perez, G., Pietrzak, K. Z., &#38; Walter, M. (2022). CoCoA: Concurrent continuous group key agreement. In <i>Advances in Cryptology – EUROCRYPT 2022</i> (Vol. 13276, pp. 815–844). Cham: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-07085-3_28\">https://doi.org/10.1007/978-3-031-07085-3_28</a>"}},{"language":[{"iso":"eng"}],"isi":1,"abstract":[{"text":"A species distributed across diverse environments may adapt to local conditions. We ask how quickly such a species changes its range in response to changed conditions. Szép et al. (Szép E, Sachdeva H, Barton NH. 2021 Polygenic local adaptation in metapopulations: a stochastic eco-evolutionary model. Evolution75, 1030–1045 (doi:10.1111/evo.14210)) used the infinite island model to find the stationary distribution of allele frequencies and deme sizes. We extend this to find how a metapopulation responds to changes in carrying capacity, selection strength, or migration rate when deme sizes are fixed. We further develop a ‘fixed-state’ approximation. Under this approximation, polymorphism is only possible for a narrow range of habitat proportions when selection is weak compared to drift, but for a much wider range otherwise. When rates of selection or migration relative to drift change in a single deme of the metapopulation, the population takes a time of order m−1 to reach the new equilibrium. However, even with many loci, there can be substantial fluctuations in net adaptation, because at each locus, alleles randomly get lost or fixed. Thus, in a finite metapopulation, variation may gradually be lost by chance, even if it would persist in an infinite metapopulation. When conditions change across the whole metapopulation, there can be rapid change, which is predicted well by the fixed-state approximation. This work helps towards an understanding of how metapopulations extend their range across diverse environments.\r\nThis article is part of the theme issue ‘Species’ ranges in the face of changing environments (Part II)’.","lang":"eng"}],"doi":"10.1098/rstb.2021.0009","publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"volume":377,"ddc":["570"],"fulldoi":"https://doi.org/10.1098/rstb.2021.0009","related_material":{"record":[{"relation":"dissertation_contains","id":"14711","status":"public"}]},"acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) [FWF P-32896B].","intvolume":"       377","issue":"1848","citation":{"mla":"Barton, Nicholas H., and Oluwafunmilola O. Olusanya. “The Response of a Metapopulation to a Changing Environment.” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>, vol. 377, no. 1848, The Royal Society, 2022, doi:<a href=\"https://doi.org/10.1098/rstb.2021.0009\">10.1098/rstb.2021.0009</a>.","ama":"Barton NH, Olusanya OO. The response of a metapopulation to a changing environment. <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. 2022;377(1848). doi:<a href=\"https://doi.org/10.1098/rstb.2021.0009\">10.1098/rstb.2021.0009</a>","short":"N.H. Barton, O.O. Olusanya, Philosophical Transactions of the Royal Society B: Biological Sciences 377 (2022).","chicago":"Barton, Nicholas H, and Oluwafunmilola O Olusanya. “The Response of a Metapopulation to a Changing Environment.” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. The Royal Society, 2022. <a href=\"https://doi.org/10.1098/rstb.2021.0009\">https://doi.org/10.1098/rstb.2021.0009</a>.","ieee":"N. H. Barton and O. O. Olusanya, “The response of a metapopulation to a changing environment,” <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>, vol. 377, no. 1848. The Royal Society, 2022.","apa":"Barton, N. H., &#38; Olusanya, O. O. (2022). The response of a metapopulation to a changing environment. <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2021.0009\">https://doi.org/10.1098/rstb.2021.0009</a>","ista":"Barton NH, Olusanya OO. 2022. The response of a metapopulation to a changing environment. Philosophical Transactions of the Royal Society B: Biological Sciences. 377(1848)."},"day":"11","external_id":{"pmid":["35184588"],"isi":["000758140300001"]},"keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"oa_version":"Published Version","has_accepted_license":"1","status":"public","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"_id":"10787","file":[{"file_name":"2022_PhilosophicalTransactionsRSB_Barton.pdf","creator":"dernst","checksum":"3b0243738f01bf3c07e0d7e8dc64f71d","relation":"main_file","access_level":"open_access","content_type":"application/pdf","date_created":"2022-08-02T06:14:32Z","file_size":1349672,"file_id":"11719","success":1,"date_updated":"2022-08-02T06:14:32Z"}],"publication":"Philosophical Transactions of the Royal Society B: Biological Sciences","author":[{"orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"},{"orcid":"0000-0003-1971-8314","last_name":"Olusanya","first_name":"Oluwafunmilola O","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","full_name":"Olusanya, Oluwafunmilola O"}],"date_published":"2022-04-11T00:00:00Z","article_processing_charge":"No","date_updated":"2026-10-21T08:24:47Z","month":"04","date_created":"2022-02-21T16:08:10Z","article_type":"original","title":"The response of a metapopulation to a changing environment","quality_controlled":"1","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file_date_updated":"2022-08-02T06:14:32Z","publisher":"The Royal Society","publication_status":"published","department":[{"_id":"GradSch"},{"_id":"NiBa"}],"project":[{"_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8","grant_number":"P32896","name":"Causes and consequences of population fragmentation"}],"type":"journal_article","scopus_import":"1","year":"2022","corr_author":"1","pmid":1},{"ddc":["576"],"volume":377,"intvolume":"       377","acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) (grant no. P-32896B).","fulldoi":"https://doi.org/10.1098/rstb.2021.0010","related_material":{"record":[{"relation":"dissertation_contains","id":"14711","status":"public"}],"link":[{"relation":"earlier_version","url":"https://doi.org/10.1101/2021.08.05.455207"}]},"isi":1,"abstract":[{"text":"We analyse how migration from a large mainland influences genetic load and population numbers on an island, in a scenario where fitness-affecting variants are unconditionally deleterious, and where numbers decline with increasing load. Our analysis shows that migration can have qualitatively different effects, depending on the total mutation target and fitness effects of deleterious variants. In particular, we find that populations exhibit a genetic Allee effect across a wide range of parameter combinations, when variants are partially recessive, cycling between low-load (large-population) and high-load (sink) states. Increased migration reduces load in the sink state (by increasing heterozygosity) but further inflates load in the large-population state (by hindering purging). We identify various critical parameter thresholds at which one or other stable state collapses, and discuss how these thresholds are influenced by the genetic versus demographic effects of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which accounts for genetic drift but neglects demographic stochasticity. We also compare against simulations which account for both demographic stochasticity and drift. Our results clarify the importance of gene flow as a key determinant of extinction risk in peripheral populations, even in the absence of ecological gradients. This article is part of the theme issue ‘Species’ ranges in the face of changing environments (part I)’.","lang":"eng"}],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"doi":"10.1098/rstb.2021.0010","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","status":"public","citation":{"mla":"Sachdeva, Himani, et al. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” <i>Philosophical Transactions of the Royal Society B</i>, vol. 377, no. 1846, 20210010, The Royal Society, 2022, doi:<a href=\"https://doi.org/10.1098/rstb.2021.0010\">10.1098/rstb.2021.0010</a>.","chicago":"Sachdeva, Himani, Oluwafunmilola O Olusanya, and Nicholas H Barton. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” <i>Philosophical Transactions of the Royal Society B</i>. The Royal Society, 2022. <a href=\"https://doi.org/10.1098/rstb.2021.0010\">https://doi.org/10.1098/rstb.2021.0010</a>.","ama":"Sachdeva H, Olusanya OO, Barton NH. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. <i>Philosophical Transactions of the Royal Society B</i>. 2022;377(1846). doi:<a href=\"https://doi.org/10.1098/rstb.2021.0010\">10.1098/rstb.2021.0010</a>","short":"H. Sachdeva, O.O. Olusanya, N.H. Barton, Philosophical Transactions of the Royal Society B 377 (2022).","ieee":"H. Sachdeva, O. O. Olusanya, and N. H. Barton, “Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity,” <i>Philosophical Transactions of the Royal Society B</i>, vol. 377, no. 1846. The Royal Society, 2022.","apa":"Sachdeva, H., Olusanya, O. O., &#38; Barton, N. H. (2022). Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. <i>Philosophical Transactions of the Royal Society B</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2021.0010\">https://doi.org/10.1098/rstb.2021.0010</a>","ista":"Sachdeva H, Olusanya OO, Barton NH. 2022. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. Philosophical Transactions of the Royal Society B. 377(1846), 20210010."},"issue":"1846","external_id":{"isi":["000745854300008"],"pmid":["35067097"]},"oa_version":"Published Version","day":"24","month":"01","date_updated":"2026-10-21T08:24:47Z","article_processing_charge":"No","title":"Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity","article_type":"original","date_created":"2022-01-24T10:34:53Z","_id":"10658","author":[{"full_name":"Sachdeva, Himani","first_name":"Himani","last_name":"Sachdeva"},{"full_name":"Olusanya, Oluwafunmilola O","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","first_name":"Oluwafunmilola O","last_name":"Olusanya","orcid":"0000-0003-1971-8314"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H"}],"date_published":"2022-01-24T00:00:00Z","publication":"Philosophical Transactions of the Royal Society B","file":[{"content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"04ca9e2f0e344d680b947f2457df8d0a","file_name":"rstb.2021.0010.pdf","creator":"oolusany","file_id":"10659","date_updated":"2022-01-24T10:34:45Z","date_created":"2022-01-24T10:34:45Z","file_size":1845792}],"year":"2022","scopus_import":"1","type":"journal_article","department":[{"_id":"GradSch"},{"_id":"NiBa"}],"project":[{"name":"Causes and consequences of population fragmentation","grant_number":"P32896","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"}],"pmid":1,"article_number":"20210010","oa":1,"quality_controlled":"1","publisher":"The Royal Society","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","file_date_updated":"2022-01-24T10:34:45Z"},{"department":[{"_id":"SyCr"}],"OA_type":"green","status":"public","type":"research_data_reference","year":"2022","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","main_file_link":[{"url":"https://doi.org/10.5061/dryad.pvmcvdnp8","open_access":"1"}],"day":"17","publisher":"Dryad","oa_version":"None","oa":1,"citation":{"apa":"Basu, A., Singh, A., Sehgal, S., Madaan, T., &#38; Prasad, N. G. (2022). Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females. Dryad. <a href=\"https://doi.org/10.5061/dryad.pvmcvdnp8\">https://doi.org/10.5061/dryad.pvmcvdnp8</a>","ista":"Basu A, Singh A, Sehgal S, Madaan T, Prasad NG. 2022. Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females, Dryad, <a href=\"https://doi.org/10.5061/dryad.pvmcvdnp8\">10.5061/dryad.pvmcvdnp8</a>.","mla":"Basu, Aabeer, et al. <i>Starvation Increases Susceptibility to Bacterial Infection and Promotes Systemic Pathogen Proliferation in Drosophila Melanogaster Females</i>. Dryad, 2022, doi:<a href=\"https://doi.org/10.5061/dryad.pvmcvdnp8\">10.5061/dryad.pvmcvdnp8</a>.","short":"A. Basu, A. Singh, S. Sehgal, T. Madaan, N.G. Prasad, (2022).","ama":"Basu A, Singh A, Sehgal S, Madaan T, Prasad NG. Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females. 2022. doi:<a href=\"https://doi.org/10.5061/dryad.pvmcvdnp8\">10.5061/dryad.pvmcvdnp8</a>","chicago":"Basu, Aabeer, Aparajita Singh, Suhaas Sehgal, Tanvi Madaan, and Nagaraj Guru Prasad. “Starvation Increases Susceptibility to Bacterial Infection and Promotes Systemic Pathogen Proliferation in Drosophila Melanogaster Females.” Dryad, 2022. <a href=\"https://doi.org/10.5061/dryad.pvmcvdnp8\">https://doi.org/10.5061/dryad.pvmcvdnp8</a>.","ieee":"A. Basu, A. Singh, S. Sehgal, T. Madaan, and N. G. Prasad, “Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females.” Dryad, 2022."},"OA_place":"repository","fulldoi":"https://doi.org/10.5061/dryad.pvmcvdnp8","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"18171"}]},"date_created":"2026-10-21T10:42:59Z","title":"Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females","article_processing_charge":"No","month":"05","date_updated":"2026-10-21T10:43:22Z","doi":"10.5061/dryad.pvmcvdnp8","author":[{"full_name":"Basu, Aabeer","last_name":"Basu","first_name":"Aabeer"},{"last_name":"Singh","first_name":"Aparajita","full_name":"Singh, Aparajita"},{"first_name":"Suhaas","last_name":"Sehgal","full_name":"Sehgal, Suhaas"},{"full_name":"Madaan, Tanvi","first_name":"Tanvi","last_name":"Madaan"},{"full_name":"Prasad, Nagaraj Guru","last_name":"Prasad","first_name":"Nagaraj Guru"}],"date_published":"2022-05-17T00:00:00Z","_id":"23180","abstract":[{"text":"Defense against pathogens and parasites requires substantial investment of energy and resources on part of the host. This makes the host immune function dependent on availability and accessibility of resources. A resource deprived host is therefore expected to be more susceptible to infections, although empirical results do not always align with this prediction. Limiting host access to resources can additionally impact within-host pathogen numbers, either directly by altering the amount of resources available to the pathogens for proliferation or indirectly by altering the efficiency of the host immune system. We tested for the effects of host starvation (complete deprivation of resources) on susceptibility to bacterial pathogens, and within-host pathogen proliferation, in Drosophila melanogaster females. Our results show that starvation increases post-infection mortality of the host, but in a pathogen-specific manner. This increase in mortality is always accompanied by increased within-host pathogen proliferation. We therefore propose that starvation compromises host resistance to bacterial infections in Drosophila melanogaster females thereby increasing susceptibility to infections.","lang":"eng"}]},{"abstract":[{"lang":"eng","text":"An action of a complex reductive group G on a smooth projective variety X is regular when all regular unipotent elements in G act with finitely many fixed points. Then the complex G-equivariant cohomology ring of X is isomorphic to the coordinate ring of a certain regular fixed point scheme. Examples include partial flag varieties, smooth Schubert varieties and Bott-Samelson varieties. We also show that a more general version of the fixed point scheme allows a generalisation to GKM spaces, such as toric varieties."}],"language":[{"iso":"eng"}],"_id":"17157","date_published":"2022-12-22T00:00:00Z","author":[{"first_name":"Tamás","orcid":"0000-0002-9582-2634","last_name":"Hausel","full_name":"Hausel, Tamás","id":"4A0666D8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Kamil P","last_name":"Rychlewicz","full_name":"Rychlewicz, Kamil P","id":"85A07246-A8BF-11E9-B4FA-D9E3E5697425"}],"publication":"arXiv","doi":"10.48550/arXiv.2212.11836","month":"12","date_updated":"2026-10-21T11:00:24Z","article_processing_charge":"No","title":"Spectrum of equivariant cohomology as a fixed point scheme","related_material":{"record":[{"status":"public","relation":"later_version","id":"19071"},{"status":"public","relation":"dissertation_contains","id":"17156"}]},"date_created":"2024-06-23T15:01:27Z","fulldoi":"https://doi.org/10.48550/arXiv.2212.11836","arxiv":1,"OA_place":"repository","oa":1,"article_number":"2212.11836","citation":{"apa":"Hausel, T., &#38; Rychlewicz, K. P. (n.d.). Spectrum of equivariant cohomology as a fixed point scheme. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2212.11836\">https://doi.org/10.48550/arXiv.2212.11836</a>","ista":"Hausel T, Rychlewicz KP. Spectrum of equivariant cohomology as a fixed point scheme. arXiv, 2212.11836.","mla":"Hausel, Tamás, and Kamil P. Rychlewicz. “Spectrum of Equivariant Cohomology as a Fixed Point Scheme.” <i>ArXiv</i>, 2212.11836, doi:<a href=\"https://doi.org/10.48550/arXiv.2212.11836\">10.48550/arXiv.2212.11836</a>.","ieee":"T. Hausel and K. P. Rychlewicz, “Spectrum of equivariant cohomology as a fixed point scheme,” <i>arXiv</i>. .","ama":"Hausel T, Rychlewicz KP. Spectrum of equivariant cohomology as a fixed point scheme. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2212.11836\">10.48550/arXiv.2212.11836</a>","chicago":"Hausel, Tamás, and Kamil P Rychlewicz. “Spectrum of Equivariant Cohomology as a Fixed Point Scheme.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2212.11836\">https://doi.org/10.48550/arXiv.2212.11836</a>.","short":"T. Hausel, K.P. Rychlewicz, ArXiv (n.d.)."},"oa_version":"Preprint","publication_status":"draft","external_id":{"arxiv":["2212.11836"]},"day":"22","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2212.11836","open_access":"1"}],"year":"2022","type":"preprint","status":"public","department":[{"_id":"GradSch"},{"_id":"TaHa"}]},{"fulldoi":"https://doi.org/10.48550/arXiv.2208.05422","related_material":{"record":[{"status":"public","id":"18132","relation":"dissertation_contains"},{"status":"public","id":"18705","relation":"later_version"}]},"das_tickbox":"0","doi":"10.48550/arXiv.2208.05422","language":[{"iso":"eng"}],"abstract":[{"text":"Given a non-singular diagonal cubic hypersurface X⊂Pn−1 over Fq(t) with char(Fq)≠3, we show that the number of rational points of height at most |P| is O(|P|3+ε) for n=6 and O(|P|2+ε) for n=4. In fact, if n=4 and char(Fq)>3 we prove that the number of rational points away from any rational line contained in X is bounded by O(|P|3/2+ε). From the result in 6 variables we deduce weak approximation for diagonal cubic hypersurfaces for n≥7 over Fq(t) when char(Fq)>3 and handle Waring's problem for cubes in 7 variables over Fq(t) when char(Fq)≠3. Our results answer a question of Davenport regarding the number of solutions of bounded height to x31+x32+x33=x34+x35+x36 with xi∈Fq[t].","lang":"eng"}],"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2208.05422"}],"day":"10","external_id":{"arxiv":["2208.05422"]},"oa_version":"Preprint","citation":{"chicago":"Glas, Jakob, and Leonhard Hochfilzer. “On a Question of Davenport and Diagonal Cubic Forms over Fq(T).” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2208.05422\">https://doi.org/10.48550/arXiv.2208.05422</a>.","ama":"Glas J, Hochfilzer L. On a question of Davenport and diagonal cubic forms over Fq(t). <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2208.05422\">10.48550/arXiv.2208.05422</a>","short":"J. Glas, L. Hochfilzer, ArXiv (n.d.).","ieee":"J. Glas and L. Hochfilzer, “On a question of Davenport and diagonal cubic forms over Fq(t),” <i>arXiv</i>. .","mla":"Glas, Jakob, and Leonhard Hochfilzer. “On a Question of Davenport and Diagonal Cubic Forms over Fq(T).” <i>ArXiv</i>, 2208.05422, doi:<a href=\"https://doi.org/10.48550/arXiv.2208.05422\">10.48550/arXiv.2208.05422</a>.","ista":"Glas J, Hochfilzer L. On a question of Davenport and diagonal cubic forms over Fq(t). arXiv, 2208.05422.","apa":"Glas, J., &#38; Hochfilzer, L. (n.d.). On a question of Davenport and diagonal cubic forms over Fq(t). <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2208.05422\">https://doi.org/10.48550/arXiv.2208.05422</a>"},"arxiv":1,"date_created":"2024-10-10T12:46:41Z","title":"On a question of Davenport and diagonal cubic forms over Fq(t)","article_processing_charge":"No","researchdata_availability":"no","month":"08","date_updated":"2026-10-21T11:06:29Z","publication":"arXiv","author":[{"first_name":"Jakob","last_name":"Glas","full_name":"Glas, Jakob","id":"d6423cba-dc74-11ea-a0a7-ee61689ff5fb"},{"last_name":"Hochfilzer","first_name":"Leonhard","full_name":"Hochfilzer, Leonhard"}],"date_published":"2022-08-10T00:00:00Z","_id":"18293","supplementarymaterial":"no","department":[{"_id":"TiBr"}],"type":"preprint","year":"2022","corr_author":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"draft","oa":1,"article_number":"2208.05422","OA_place":"repository"},{"file":[{"relation":"main_file","checksum":"7f6f860b20b8de2a249e9c1b4eee15cf","file_name":"2022_LNCS_Bartocci.pdf","creator":"dernst","content_type":"application/pdf","access_level":"open_access","date_created":"2022-05-09T06:52:44Z","file_size":479146,"success":1,"file_id":"11357","date_updated":"2022-05-09T06:52:44Z"}],"publication":"Fundamental Approaches to Software Engineering","author":[{"first_name":"Ezio","last_name":"Bartocci","full_name":"Bartocci, Ezio"},{"first_name":"Thomas","last_name":"Ferrere","orcid":"0000-0001-5199-3143","full_name":"Ferrere, Thomas","id":"40960E6E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Henzinger","orcid":"0000-0002-2985-7724","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A"},{"id":"41BCEE5C-F248-11E8-B48F-1D18A9856A87","full_name":"Nickovic, Dejan","last_name":"Nickovic","first_name":"Dejan"},{"last_name":"Da Costa","first_name":"Ana Oliveira","full_name":"Da Costa, Ana Oliveira"}],"date_published":"2022-03-29T00:00:00Z","_id":"11355","conference":{"end_date":"2022-04-07","start_date":"2022-04-02","location":"Munich, Germany","name":"FASE: Fundamental Approaches to Software Engineering"},"ec_funded":1,"date_created":"2022-05-08T22:01:44Z","title":"Information-flow interfaces","article_processing_charge":"No","date_updated":"2026-10-21T12:02:28Z","month":"03","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","page":"3-22","file_date_updated":"2022-05-09T06:52:44Z","publisher":"Springer Nature","publication_status":"published","oa":1,"quality_controlled":"1","department":[{"_id":"ToHe"}],"project":[{"call_identifier":"H2020","name":"Vigilant Algorithmic Monitoring of Software","grant_number":"101020093","_id":"62781420-2b32-11ec-9570-8d9b63373d4d"}],"type":"conference","year":"2022","scopus_import":"1","doi":"10.1007/978-3-030-99429-7_1","publication_identifier":{"isbn":["9783030994280"],"eissn":["1611-3349"],"issn":["0302-9743"]},"language":[{"iso":"eng"}],"isi":1,"abstract":[{"lang":"eng","text":"Contract-based design is a promising methodology for taming the complexity of developing sophisticated systems. A formal contract distinguishes between assumptions, which are constraints that the designer of a component puts on the environments in which the component can be used safely, and guarantees, which are promises that the designer asks from the team that implements the component. A theory of formal contracts can be formalized as an interface theory, which supports the composition and refinement of both assumptions and guarantees.\r\nAlthough there is a rich landscape of contract-based design methods that address functional and extra-functional properties, we present the first interface theory that is designed for ensuring system-wide security properties. Our framework provides a refinement relation and a composition operation that support both incremental design and independent implementability. We develop our theory for both stateless and stateful interfaces. We illustrate the applicability of our framework with an example inspired from the automotive domain."}],"alternative_title":["LNCS"],"fulldoi":"https://doi.org/10.1007/978-3-030-99429-7_1","related_material":{"record":[{"status":"public","relation":"extended_version","id":"17094"}]},"intvolume":"     13241","acknowledgement":"This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 956123 and was funded in part by the FWF project W1255-N23 and by the ERC-2020-AdG 101020093.","volume":13241,"ddc":["000"],"day":"29","external_id":{"isi":["000782393600001"]},"oa_version":"Published Version","citation":{"ieee":"E. Bartocci, T. Ferrere, T. A. Henzinger, D. Nickovic, and A. O. Da Costa, “Information-flow interfaces,” in <i>Fundamental Approaches to Software Engineering</i>, Munich, Germany, 2022, vol. 13241, pp. 3–22.","chicago":"Bartocci, Ezio, Thomas Ferrere, Thomas A Henzinger, Dejan Nickovic, and Ana Oliveira Da Costa. “Information-Flow Interfaces.” In <i>Fundamental Approaches to Software Engineering</i>, 13241:3–22. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/978-3-030-99429-7_1\">https://doi.org/10.1007/978-3-030-99429-7_1</a>.","short":"E. Bartocci, T. Ferrere, T.A. Henzinger, D. Nickovic, A.O. Da Costa, in:, Fundamental Approaches to Software Engineering, Springer Nature, 2022, pp. 3–22.","ama":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. Information-flow interfaces. In: <i>Fundamental Approaches to Software Engineering</i>. Vol 13241. Springer Nature; 2022:3-22. doi:<a href=\"https://doi.org/10.1007/978-3-030-99429-7_1\">10.1007/978-3-030-99429-7_1</a>","mla":"Bartocci, Ezio, et al. “Information-Flow Interfaces.” <i>Fundamental Approaches to Software Engineering</i>, vol. 13241, Springer Nature, 2022, pp. 3–22, doi:<a href=\"https://doi.org/10.1007/978-3-030-99429-7_1\">10.1007/978-3-030-99429-7_1</a>.","ista":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. 2022. Information-flow interfaces. Fundamental Approaches to Software Engineering. FASE: Fundamental Approaches to Software Engineering, LNCS, vol. 13241, 3–22.","apa":"Bartocci, E., Ferrere, T., Henzinger, T. A., Nickovic, D., &#38; Da Costa, A. O. (2022). Information-flow interfaces. In <i>Fundamental Approaches to Software Engineering</i> (Vol. 13241, pp. 3–22). Munich, Germany: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-99429-7_1\">https://doi.org/10.1007/978-3-030-99429-7_1</a>"},"has_accepted_license":"1","status":"public","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"}},{"title":"History-deterministic timed automata","date_created":"2023-02-05T17:24:23Z","date_updated":"2026-10-21T13:12:36Z","month":"09","article_processing_charge":"No","author":[{"full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","last_name":"Henzinger","orcid":"0000-0002-2985-7724"},{"first_name":"Karoliina","last_name":"Lehtinen","full_name":"Lehtinen, Karoliina"},{"full_name":"Totzke, Patrick","first_name":"Patrick","last_name":"Totzke"}],"date_published":"2022-09-06T00:00:00Z","file":[{"access_level":"open_access","content_type":"application/pdf","file_name":"2022_LIPICs_Henzinger2.pdf","creator":"dernst","checksum":"9e97e15628f66b2ad77f535bb0327dee","relation":"main_file","date_updated":"2023-02-06T09:21:09Z","file_id":"12520","success":1,"date_created":"2023-02-06T09:21:09Z","file_size":717940}],"publication":"33rd International Conference on Concurrency Theory","_id":"12508","conference":{"end_date":"2022-09-16","location":"Warsaw, Poland","name":"CONCUR: Conference on Concurrency Theory","start_date":"2022-09-13"},"ec_funded":1,"year":"2022","type":"conference","scopus_import":"1","corr_author":"1","department":[{"_id":"ToHe"}],"project":[{"name":"Vigilant Algorithmic Monitoring of Software","call_identifier":"H2020","grant_number":"101020093","_id":"62781420-2b32-11ec-9570-8d9b63373d4d"}],"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"14:1-14:21","file_date_updated":"2023-02-06T09:21:09Z","quality_controlled":"1","oa":1,"acknowledgement":"Thomas A. Henzinger: This work was supported in part by the ERC-2020-AdG 101020093.\r\nPatrick Totzke: acknowledges support from the EPSRC, project no. EP/V025848/1.\r\n","intvolume":"       243","alternative_title":["LIPIcs"],"fulldoi":"https://doi.org/10.4230/LIPIcs.CONCUR.2022.14","related_material":{"record":[{"status":"public","relation":"later_version","id":"18530"}]},"ddc":["000"],"volume":243,"das_tickbox":"1","publication_identifier":{"isbn":["9783959772464"],"issn":["1868-8969"]},"doi":"10.4230/LIPIcs.CONCUR.2022.14","abstract":[{"text":"We explore the notion of history-determinism in the context of timed automata (TA). History-deterministic automata are those in which nondeterminism can be resolved on the fly, based on the run constructed thus far. History-determinism is a robust property that admits different game-based characterisations, and history-deterministic specifications allow for game-based verification without an expensive determinization step.\r\nWe show yet another characterisation of history-determinism in terms of fair simulation, at the general level of labelled transition systems: a system is history-deterministic precisely if and only if it fairly simulates all language smaller systems.\r\nFor timed automata over infinite timed words it is known that universality is undecidable for Büchi TA. We show that for history-deterministic TA with arbitrary parity acceptance, timed universality, inclusion, and synthesis all remain decidable and are ExpTime-complete.\r\nFor the subclass of TA with safety or reachability acceptance, we show that checking whether such an automaton is history-deterministic is decidable (in ExpTime), and history-deterministic TA with safety acceptance are effectively determinizable without introducing new automata states.","lang":"eng"}],"language":[{"iso":"eng"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","status":"public","oa_version":"Published Version","day":"06","citation":{"mla":"Henzinger, Thomas A., et al. “History-Deterministic Timed Automata.” <i>33rd International Conference on Concurrency Theory</i>, vol. 243, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022, p. 14:1-14:21, doi:<a href=\"https://doi.org/10.4230/LIPIcs.CONCUR.2022.14\">10.4230/LIPIcs.CONCUR.2022.14</a>.","ieee":"T. A. Henzinger, K. Lehtinen, and P. Totzke, “History-deterministic timed automata,” in <i>33rd International Conference on Concurrency Theory</i>, Warsaw, Poland, 2022, vol. 243, p. 14:1-14:21.","chicago":"Henzinger, Thomas A, Karoliina Lehtinen, and Patrick Totzke. “History-Deterministic Timed Automata.” In <i>33rd International Conference on Concurrency Theory</i>, 243:14:1-14:21. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022. <a href=\"https://doi.org/10.4230/LIPIcs.CONCUR.2022.14\">https://doi.org/10.4230/LIPIcs.CONCUR.2022.14</a>.","short":"T.A. Henzinger, K. Lehtinen, P. Totzke, in:, 33rd International Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022, p. 14:1-14:21.","ama":"Henzinger TA, Lehtinen K, Totzke P. History-deterministic timed automata. In: <i>33rd International Conference on Concurrency Theory</i>. Vol 243. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2022:14:1-14:21. doi:<a href=\"https://doi.org/10.4230/LIPIcs.CONCUR.2022.14\">10.4230/LIPIcs.CONCUR.2022.14</a>","apa":"Henzinger, T. A., Lehtinen, K., &#38; Totzke, P. (2022). History-deterministic timed automata. In <i>33rd International Conference on Concurrency Theory</i> (Vol. 243, p. 14:1-14:21). Warsaw, Poland: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.CONCUR.2022.14\">https://doi.org/10.4230/LIPIcs.CONCUR.2022.14</a>","ista":"Henzinger TA, Lehtinen K, Totzke P. 2022. History-deterministic timed automata. 33rd International Conference on Concurrency Theory. CONCUR: Conference on Concurrency Theory, LIPIcs, vol. 243, 14:1-14:21."}},{"citation":{"ama":"Radler P. In vitro reconstitution of Escherichia coli divisome activation. 2022. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10934\">10.15479/AT:ISTA:10934</a>","short":"P. Radler, (2022).","chicago":"Radler, Philipp. “In Vitro Reconstitution of Escherichia Coli Divisome Activation.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/AT:ISTA:10934\">https://doi.org/10.15479/AT:ISTA:10934</a>.","ieee":"P. Radler, “In vitro reconstitution of Escherichia coli divisome activation.” Institute of Science and Technology Austria, 2022.","mla":"Radler, Philipp. <i>In Vitro Reconstitution of Escherichia Coli Divisome Activation</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10934\">10.15479/AT:ISTA:10934</a>.","ista":"Radler P. 2022. In vitro reconstitution of Escherichia coli divisome activation, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:10934\">10.15479/AT:ISTA:10934</a>.","apa":"Radler, P. (2022). In vitro reconstitution of Escherichia coli divisome activation. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:10934\">https://doi.org/10.15479/AT:ISTA:10934</a>"},"keyword":["Bacterial cell division","in vitro reconstitution","FtsZ","FtsN","FtsA"],"oa_version":"Submitted Version","day":"05","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","status":"public","abstract":[{"text":"FtsA is crucial for assembly of the E. coli divisome, as it dynamically links cytoplasmic FtsZ filaments with transmembrane cell division proteins. FtsA allegedly initiates cell division by switching from an inactive polymeric to an active monomeric confirmation, which recruits downstream proteins and stabilizes FtsZ filaments. Here, we use biochemical reconstitution experiments combined with quantitative fluorescence microscopy to study divisome activation in vitro. We compare wildtype-FtsA with FtsA-R286W, a constantly active gain-of-function mutant and find that R286W outperforms the wildtype protein in replicating FtsZ treadmilling dynamics, stabilizing FtsZ filaments and recruiting FtsN. We attribute these differences to a faster membrane exchange of FtsA-R286W and its higher packing density below FtsZ filaments.  Using FRET microscopy, we find that FtsN binding does not compete with, but promotes FtsA self-interaction. Our findings suggest a model where FtsA always forms dynamic polymers on the membrane, which re-organize during assembly and activation of the divisome. ","lang":"eng"}],"doi":"10.15479/AT:ISTA:10934","ddc":["572"],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"acknowledgement":"We acknowledge members of the Loose laboratory at IST Austria for helpful discussions—in particular L. Lindorfer for his assistance with cloning and purifications. We thank J. Löwe and T. Nierhaus (MRC-LMB Cambridge, UK) for sharing unpublished work and helpful discussions, as well as D. Vavylonis and D. Rutkowski (Lehigh University, Bethlehem, PA, USA) as well as S. Martin (University of Lausanne, Switzerland) for sharing their code for FRAP analysis. We are also thankful for the support by the Scientific Service Units (SSU) of IST Austria through resources provided by the Imaging and Optics Facility (IOF) and the Lab Support Facility (LSF). This work was supported by the European Research Council through grant ERC 2015-StG-679239 and by the Austrian Science Fund (FWF) StandAlone P34607 to M.L. and HFSP LT 000824/2016-L4 to N.B. For the purpose of open access, we have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.","fulldoi":"https://doi.org/10.15479/AT:ISTA:10934","related_material":{"link":[{"relation":"software","description":"A custom written code (FRAPdiff) to quantify the Off binding rate and Diffusion coefficient of membrane bound proteins. 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division"}],"_id":"10934","contributor":[{"last_name":"Loose","orcid":"0000-0001-7309-9724","first_name":"Martin","contributor_type":"supervisor","id":"462D4284-F248-11E8-B48F-1D18A9856A87"},{"id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph M","last_name":"Sommer","contributor_type":"researcher"},{"first_name":"Paulo","last_name":"Caldas","contributor_type":"researcher"},{"contributor_type":"researcher","first_name":"David","last_name":"Michalik","id":"B9577E20-AA38-11E9-AC9A-0930E6697425"},{"first_name":"Natalia","last_name":"Baranova","contributor_type":"researcher"}],"ec_funded":1,"author":[{"full_name":"Radler, Philipp","id":"40136C2A-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","last_name":"Radler","orcid":" 0000-0001-9198-2182 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While synaptic transmission remains a dynamic process, electron microscopy provides images with comparably low temporal resolution (Studer et al., 2014). The current work overcomes this challenge and describes an improved “Flash and Freeze” technique (Watanabe et al., 2013a; Watanabe et al., 2013b) to study synaptic transmission at the hippocampal mossy fiber-CA3 pyramidal neuron synapses, using mouse acute brain slices and organotypic slices culture. The improved method allowed for selective stimulation of presynaptic mossy fiber boutons and the observation of synaptic vesicle pool dynamics at the active zones. Our results uncovered several intriguing morphological features of mossy fiber boutons. First, the docked vesicle pool was largely depleted (more than 70%) after stimulation, implying that the docked synaptic vesicles pool and readily releasable pool are vastly overlapping in mossy fiber boutons. Second, the synaptic vesicles are skewed towards larger diameters, displaying a wide range of sizes. An increase in the mean diameter of synaptic vesicles, after single and repetitive stimulation, suggests that smaller vesicles have a higher release probability. Third, we observed putative endocytotic structures after moderate light stimulation, matching the timing of previously described ultrafast endocytosis (Watanabe et al., 2013a; Delvendahl et al., 2016). \r\n\tIn addition, synaptic transmission depends on a sophisticated system of protein machinery and calcium channels (Südhof, 2013b), which amplifies the challenge in studying synaptic communication as these interactions can be potentially modified during synaptic plasticity. And although recent study elucidated the potential correlation between physiological and morphological properties of synapses during synaptic plasticity (Vandael et al., 2020), the molecular underpinning of it remains unknown. Thus, the presented work tries to overcome this challenge and aims to pinpoint changes in the molecular architecture at hippocampal mossy fiber bouton synapses during short- and long-term potentiation (STP and LTP), we combined chemical potentiation, with the application of a cyclic adenosine monophosphate agonist (i.e. forskolin) and freeze-fracture replica immunolabelling. This method allowed the localization of membrane-bound proteins with nanometer precision within the active zone, in particular, P/Q-type calcium channels and synaptic vesicle priming proteins Munc13-1/2. First, we found that the number of clusters of Munc13-1 in the mossy fiber bouton active zone increased significantly during STP, but decreased to lower than the control value during LTP. Secondly, although the distance between the calcium channels and Munc13-1s did not change after induction of STP, it shortened during the LTP phase. Additionally, forskolin did not affect Munc13-2 distribution during STP and LTP. These results indicate the existence of two distinct mechanisms that govern STP and LTP at mossy fiber bouton synapses: an increase in the readily realizable pool in the case of STP and a potential increase in release probability during LTP. “Flash and freeze” and functional electron microscopy, are versatile methods that can be successfully applied to intact brain circuits to study synaptic transmission even at the molecular level.\r\n","lang":"eng"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/at:ista:11196","ddc":["570"],"acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"PreCl"}],"alternative_title":["ISTA Thesis"],"fulldoi":"https://doi.org/10.15479/at:ista:11196","related_material":{"record":[{"relation":"part_of_dissertation","id":"7473","status":"public"},{"status":"public","id":"11222","relation":"part_of_dissertation"}]},"citation":{"ieee":"O. Kim, “Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses,” Institute of Science and Technology Austria, 2022.","short":"O. Kim, Nanoarchitecture of Hippocampal Mossy Fiber-CA3 Pyramidal Neuron Synapses, Institute of Science and Technology Austria, 2022.","ama":"Kim O. Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:11196\">10.15479/at:ista:11196</a>","chicago":"Kim, Olena. “Nanoarchitecture of Hippocampal Mossy Fiber-CA3 Pyramidal Neuron Synapses.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:11196\">https://doi.org/10.15479/at:ista:11196</a>.","mla":"Kim, Olena. <i>Nanoarchitecture of Hippocampal Mossy Fiber-CA3 Pyramidal Neuron Synapses</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:11196\">10.15479/at:ista:11196</a>.","ista":"Kim O. 2022. Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses. Institute of Science and Technology Austria.","apa":"Kim, O. (2022). <i>Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:11196\">https://doi.org/10.15479/at:ista:11196</a>"},"supervisor":[{"orcid":"0000-0001-5001-4804","last_name":"Jonas","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M"}],"oa_version":"Published Version","day":"20","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"status":"public","has_accepted_license":"1","degree_awarded":"PhD","_id":"11196","ec_funded":1,"author":[{"orcid":"0000-0003-2344-1039","last_name":"Kim","first_name":"Olena","id":"3F8ABDDA-F248-11E8-B48F-1D18A9856A87","full_name":"Kim, Olena"}],"date_published":"2022-04-20T00:00:00Z","file":[{"embargo":"2023-04-19","creator":"okim","file_name":"Olena_KIM_thesis_final.pdf","checksum":"1616a8bf6f13a57c892dac873dcd0936","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_size":21273537,"date_created":"2022-04-20T14:21:56Z","file_id":"11220","date_updated":"2023-04-20T22:30:03Z"},{"access_level":"closed","content_type":"application/x-zip-compressed","embargo_to":"open_access","file_name":"KIM_thesis_final.zip","creator":"okim","relation":"source_file","checksum":"1acb433f98dc42abb0b4b0cbb0c4b918","date_updated":"2023-04-20T22:30:03Z","file_id":"11221","file_size":59248569,"date_created":"2022-04-20T14:22:56Z"}],"date_updated":"2026-06-18T10:49:27Z","month":"04","article_processing_charge":"No","title":"Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses","date_created":"2022-04-20T09:47:12Z","oa":1,"OA_place":"publisher","publisher":"Institute of Science and Technology Austria","publication_status":"published","page":"132","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","file_date_updated":"2023-04-20T22:30:03Z","year":"2022","type":"dissertation","corr_author":"1","department":[{"_id":"PeJo"},{"_id":"GradSch"}],"project":[{"name":"Presynaptic calcium channels distribution and impact on coupling at the hippocampal mossy fiber synapse","call_identifier":"H2020","grant_number":"708497","_id":"25BAF7B2-B435-11E9-9278-68D0E5697425"},{"_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","grant_number":"692692","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","call_identifier":"H2020"},{"name":"Zellkommunikation in Gesundheit und Krankheit","call_identifier":"FWF","_id":"25C3DBB6-B435-11E9-9278-68D0E5697425","grant_number":"W01205"},{"call_identifier":"FWF","name":"Synaptic communication in neuronal microcircuits","_id":"25C5A090-B435-11E9-9278-68D0E5697425","grant_number":"Z00312"}],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/"},{"ddc":["580"],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"SSU"}],"acknowledgement":"I would like to acknowledge ISTA and all the people from the Scientific Service Units and at ISTA, in particular Dorota Jaworska for excellent technical and scientific support as well as ÖAW for funding my research for over 3 years (DOC ÖAW Fellowship PR1022OEAW02).","fulldoi":"https://doi.org/10.15479/at:ista:11879","alternative_title":["ISTA Thesis"],"abstract":[{"text":"As the overall global mean surface temperature is increasing due to climate change, plant\r\nadaptation to those stressful conditions is of utmost importance for their survival. Plants are\r\nsessile organisms, thus to compensate for their lack of mobility, they evolved a variety of\r\nmechanisms enabling them to flexibly adjust their physiological, growth and developmental\r\nprocesses to fluctuating temperatures and to survive in harsh environments. While these unique\r\nadaptation abilities provide an important evolutionary advantage, overall modulation of plant\r\ngrowth and developmental program due to non-optimal temperature negatively affects biomass\r\nproduction, crop productivity or sensitivity to pathogens. Thus, understanding molecular\r\nprocesses underlying plant adaptation to increased temperature can provide important\r\nresources for breeding strategies to ensure sufficient agricultural food production.\r\nAn increase in ambient temperature by a few degrees leads to profound changes in organ growth\r\nincluding enhanced hypocotyl elongation, expansion of petioles, hyponastic growth of leaves and\r\ncotyledons, collectively named thermomorphogenesis (Casal & Balasubramanian, 2019). Auxin,\r\none of the best-studied growth hormones, plays an essential role in this process by direct\r\nactivation of transcriptional and non-transcriptional processes resulting in elongation growth\r\n(Majda & Robert, 2018).To modulate hypocotyl growth in response to high ambient temperature\r\n(hAT), auxin needs to be redistributed accordingly. PINs, auxin efflux transporters, are key\r\ncomponents of the polar auxin transport (PAT) machinery, which controls the amount and\r\ndirection of auxin translocated in the plant tissues and organs(Adamowski & Friml, 2015). Hence,\r\nPIN-mediated transport is tightly linked with thermo-morphogenesis, and interference with PAT\r\nthrough either chemical or genetic means dramatically affecting the adaptive responses to hAT.\r\nIntriguingly, despite the key role of PIN mediated transport in growth response to hAT, whether\r\nand how PINs at the level of expression adapt to fluctuation in temperature is scarcely\r\nunderstood.\r\nWith genetic, molecular and advanced bio-imaging approaches, we demonstrate the role of PIN\r\nauxin transporters in the regulation of hypocotyl growth in response to hAT. We show that via\r\nadjustment of PIN3, PIN4 and PIN7 expression in cotyledons and hypocotyls, auxin distribution is modulated thereby determining elongation pattern of epidermal cells at hAT. Furthermore, we\r\nidentified three Zinc-Finger (ZF) transcription factors as novel molecular components of the\r\nthermo-regulatory network, which through negative regulation of PIN transcription adjust the\r\ntransport of auxin at hAT. Our results suggest that the ZF-PIN module might be a part of the\r\nnegative feedback loop attenuating the activity of the thermo-sensing pathway to restrain\r\nexaggerated growth and developmental responses to hAT.","lang":"eng"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-022-0"]},"doi":"10.15479/at:ista:11879","status":"public","has_accepted_license":"1","degree_awarded":"PhD","citation":{"apa":"Artner, C. (2022). <i>Modulation of auxin transport via ZF proteins adjust plant response to high ambient temperature</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:11879\">https://doi.org/10.15479/at:ista:11879</a>","ista":"Artner C. 2022. Modulation of auxin transport via ZF proteins adjust plant response to high ambient temperature. Institute of Science and Technology Austria.","mla":"Artner, Christina. <i>Modulation of Auxin Transport via ZF Proteins Adjust Plant Response to High Ambient Temperature</i>. Institute of Science and Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/at:ista:11879\">10.15479/at:ista:11879</a>.","ieee":"C. Artner, “Modulation of auxin transport via ZF proteins adjust plant response to high ambient temperature,” Institute of Science and Technology Austria, 2022.","ama":"Artner C. Modulation of auxin transport via ZF proteins adjust plant response to high ambient temperature. 2022. doi:<a href=\"https://doi.org/10.15479/at:ista:11879\">10.15479/at:ista:11879</a>","short":"C. Artner, Modulation of Auxin Transport via ZF Proteins Adjust Plant Response to High Ambient Temperature, Institute of Science and Technology Austria, 2022.","chicago":"Artner, Christina. “Modulation of Auxin Transport via ZF Proteins Adjust Plant Response to High Ambient Temperature.” Institute of Science and Technology Austria, 2022. <a href=\"https://doi.org/10.15479/at:ista:11879\">https://doi.org/10.15479/at:ista:11879</a>."},"supervisor":[{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","full_name":"Benková, Eva","orcid":"0000-0002-8510-9739","last_name":"Benková","first_name":"Eva"}],"oa_version":"Published Version","keyword":["high ambient temperature","auxin","PINs","Zinc-Finger proteins","thermomorphogenesis","stress"],"day":"17","date_updated":"2026-04-07T14:30:39Z","month":"08","article_processing_charge":"No","title":"Modulation of auxin transport via ZF proteins adjust plant response to high ambient temperature","date_created":"2022-08-17T07:58:53Z","_id":"11879","date_published":"2022-08-17T00:00:00Z","author":[{"last_name":"Artner","first_name":"Christina","id":"45DF286A-F248-11E8-B48F-1D18A9856A87","full_name":"Artner, Christina"}],"file":[{"file_size":11113608,"date_created":"2022-08-17T12:08:49Z","date_updated":"2023-09-09T22:30:03Z","file_id":"11907","relation":"main_file","checksum":"a2c2fdc28002538840490bfa6a08b2cb","embargo":"2023-09-08","file_name":"ChristinaArtner_PhD_Thesis_2022.pdf","creator":"cartner","content_type":"application/pdf","access_level":"open_access"},{"creator":"cartner","file_name":"ChristinaArtner_PhD_Thesis_2022.7z","relation":"source_file","checksum":"66b461c074b815fbe63481b3f46a9f43","embargo_to":"open_access","access_level":"closed","content_type":"application/octet-stream","file_size":19097730,"date_created":"2022-08-17T12:08:59Z","file_id":"11908","date_updated":"2023-09-09T22:30:03Z"}],"corr_author":"1","type":"dissertation","year":"2022","project":[{"_id":"2685A872-B435-11E9-9278-68D0E5697425","name":"Hormonal regulation of plant adaptive responses to environmental signals"}],"department":[{"_id":"GradSch"},{"_id":"EvBe"}],"OA_place":"publisher","oa":1,"publication_status":"published","publisher":"Institute of Science and Technology Austria","file_date_updated":"2023-09-09T22:30:03Z","page":"128","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"oa":1,"quality_controlled":"1","article_number":"2635","publication_status":"published","publisher":"Springer Nature","file_date_updated":"2022-05-13T09:10:51Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","corr_author":"1","scopus_import":"1","type":"journal_article","year":"2022","project":[{"grant_number":"679239","_id":"2595697A-B435-11E9-9278-68D0E5697425","name":"Self-Organization of the Bacterial Cell","call_identifier":"H2020"},{"name":"In vitro reconstitution of bacterial cell division","_id":"fc38323b-9c52-11eb-aca3-ff8afb4a011d","grant_number":"P34607"}],"department":[{"_id":"MaLo"}],"ec_funded":1,"_id":"11373","date_published":"2022-05-12T00:00:00Z","author":[{"id":"40136C2A-F248-11E8-B48F-1D18A9856A87","full_name":"Radler, Philipp","last_name":"Radler","orcid":"0000-0001-9198-2182 ","first_name":"Philipp"},{"full_name":"Baranova, Natalia S.","id":"38661662-F248-11E8-B48F-1D18A9856A87","first_name":"Natalia S.","last_name":"Baranova","orcid":"0000-0002-3086-9124"},{"full_name":"Dos Santos Caldas, Paulo R","id":"38FCDB4C-F248-11E8-B48F-1D18A9856A87","first_name":"Paulo R","orcid":"0000-0001-6730-4461","last_name":"Dos Santos Caldas"},{"last_name":"Sommer","orcid":"0000-0003-1216-9105","first_name":"Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","full_name":"Sommer, Christoph M"},{"last_name":"Lopez Pelegrin","first_name":"Maria D","id":"319AA9CE-F248-11E8-B48F-1D18A9856A87","full_name":"Lopez Pelegrin, Maria D"},{"id":"B9577E20-AA38-11E9-AC9A-0930E6697425","full_name":"Michalik, David","last_name":"Michalik","first_name":"David"},{"full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","first_name":"Martin","orcid":"0000-0001-7309-9724","last_name":"Loose"}],"file":[{"success":1,"file_id":"11374","date_updated":"2022-05-13T09:10:51Z","date_created":"2022-05-13T09:10:51Z","file_size":6945191,"content_type":"application/pdf","access_level":"open_access","checksum":"5af863ee1b95a0710f6ee864d68dc7a6","relation":"main_file","creator":"dernst","file_name":"2022_NatureCommunications_Radler.pdf"}],"publication":"Nature Communications","date_updated":"2026-11-07T23:30:05Z","month":"05","article_processing_charge":"No","article_type":"original","title":"In vitro reconstitution of Escherichia coli divisome activation","date_created":"2022-05-13T09:06:28Z","citation":{"mla":"Radler, Philipp, et al. “In Vitro Reconstitution of Escherichia Coli Divisome Activation.” <i>Nature Communications</i>, vol. 13, 2635, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-30301-y\">10.1038/s41467-022-30301-y</a>.","ieee":"P. Radler <i>et al.</i>, “In vitro reconstitution of Escherichia coli divisome activation,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","ama":"Radler P, Baranova NS, Dos Santos Caldas PR, et al. In vitro reconstitution of Escherichia coli divisome activation. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-30301-y\">10.1038/s41467-022-30301-y</a>","chicago":"Radler, Philipp, Natalia S. Baranova, Paulo R Dos Santos Caldas, Christoph M Sommer, Maria D Lopez Pelegrin, David Michalik, and Martin Loose. “In Vitro Reconstitution of Escherichia Coli Divisome Activation.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-30301-y\">https://doi.org/10.1038/s41467-022-30301-y</a>.","short":"P. Radler, N.S. Baranova, P.R. Dos Santos Caldas, C.M. Sommer, M.D. Lopez Pelegrin, D. Michalik, M. Loose, Nature Communications 13 (2022).","apa":"Radler, P., Baranova, N. S., Dos Santos Caldas, P. R., Sommer, C. M., Lopez Pelegrin, M. D., Michalik, D., &#38; Loose, M. (2022). In vitro reconstitution of Escherichia coli divisome activation. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-30301-y\">https://doi.org/10.1038/s41467-022-30301-y</a>","ista":"Radler P, Baranova NS, Dos Santos Caldas PR, Sommer CM, Lopez Pelegrin MD, Michalik D, Loose M. 2022. In vitro reconstitution of Escherichia coli divisome activation. Nature Communications. 13, 2635."},"oa_version":"Published Version","keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry"],"external_id":{"isi":["000795171100037"]},"day":"12","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","has_accepted_license":"1","abstract":[{"text":"The actin-homologue FtsA is essential for E. coli cell division, as it links FtsZ filaments in the Z-ring to transmembrane proteins. FtsA is thought to initiate cell constriction by switching from an inactive polymeric to an active monomeric conformation, which recruits downstream proteins and stabilizes the Z-ring. However, direct biochemical evidence for this mechanism is missing. Here, we use reconstitution experiments and quantitative fluorescence microscopy to study divisome activation in vitro. By comparing wild-type FtsA with FtsA R286W, we find that this hyperactive mutant outperforms FtsA WT in replicating FtsZ treadmilling dynamics, FtsZ filament stabilization and recruitment of FtsN. We could attribute these differences to a faster exchange and denser packing of FtsA R286W below FtsZ filaments. Using FRET microscopy, we also find that FtsN binding promotes FtsA self-interaction. We propose that in the active divisome FtsA and FtsN exist as a dynamic copolymer that follows treadmilling filaments of FtsZ.","lang":"eng"}],"isi":1,"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2041-1723"]},"doi":"10.1038/s41467-022-30301-y","ddc":["570"],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"volume":13,"intvolume":"        13","acknowledgement":"We acknowledge members of the Loose laboratory at IST Austria for helpful discussions—in particular L. Lindorfer for his assistance with cloning and purifications. We thank J. Löwe and T. Nierhaus (MRC-LMB Cambridge, UK) for sharing unpublished work and helpful discussions, as well as D. Vavylonis and D. Rutkowski (Lehigh University, Bethlehem, PA, USA) and S. Martin (University of Lausanne, Switzerland) for sharing their code for FRAP analysis. We are also thankful for the support by the Scientific Service Units (SSU) of IST Austria through resources provided by the Imaging and Optics Facility (IOF) and the Lab Support Facility (LSF). This work was supported by the European Research Council through grant ERC 2015-StG-679239 and by the Austrian Science Fund (FWF) StandAlone P34607 to M.L. and HFSP LT 000824/2016-L4 to N.B. For the purpose of open access, we have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41467-022-34485-1"}],"record":[{"id":"10934","relation":"research_data","status":"public"},{"status":"public","id":"14280","relation":"dissertation_contains"}]},"fulldoi":"https://doi.org/10.1038/s41467-022-30301-y"}]