[{"month":"02","_id":"21113","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-02-16T08:15:11Z","year":"2026","OA_place":"publisher","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2510.13583","open_access":"1"}],"date_published":"2026-02-11T00:00:00Z","day":"11","ddc":["000"],"citation":{"apa":"Montagna, F. (n.d.). On the identifiability of causal graphs with multiple environments. In <i>The 14th International Conference on Learning Representations</i>. Rio de Janeiro, Brazil: OpenReview.","ista":"Montagna F. On the identifiability of causal graphs with multiple environments. The 14th International Conference on Learning Representations. ICLR: International Conference on Learning Representations.","ieee":"F. Montagna, “On the identifiability of causal graphs with multiple environments,” in <i>The 14th International Conference on Learning Representations</i>, Rio de Janeiro, Brazil.","chicago":"Montagna, Francesco. “On the Identifiability of Causal Graphs with Multiple Environments.” In <i>The 14th International Conference on Learning Representations</i>. OpenReview, n.d.","mla":"Montagna, Francesco. “On the Identifiability of Causal Graphs with Multiple Environments.” <i>The 14th International Conference on Learning Representations</i>, OpenReview.","short":"F. Montagna, in:, The 14th International Conference on Learning Representations, OpenReview, n.d.","ama":"Montagna F. On the identifiability of causal graphs with multiple environments. In: <i>The 14th International Conference on Learning Representations</i>. OpenReview."},"type":"conference","language":[{"iso":"eng"}],"publication":"The 14th International Conference on Learning Representations","corr_author":"1","author":[{"id":"353afc8e-19f4-11f0-9db9-811f1723c83f","first_name":"Francesco","last_name":"Montagna","full_name":"Montagna, Francesco"}],"publisher":"OpenReview","department":[{"_id":"FrLo"}],"status":"public","has_accepted_license":"1","conference":{"end_date":"2026-04-27","name":"ICLR: International Conference on Learning Representations","location":"Rio de Janeiro, Brazil","start_date":"2026-04-23"},"oa":1,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"OA_type":"gold","oa_version":"Published Version","date_created":"2026-01-30T08:16:25Z","publication_status":"accepted","arxiv":1,"article_processing_charge":"No","title":"On the identifiability of causal graphs with multiple environments","external_id":{"arxiv":["2510.13583"]},"abstract":[{"text":"Causal discovery from i.i.d. observational data is known to be generally ill-posed. We demonstrate that if we have access to the distribution induced by a structural causal model, and additional data from (in the best case) only two environments that sufficiently differ in the noise statistics, the unique causal graph is identifiable. Notably, this is the first result in the literature that guarantees the entire causal graph recovery with a constant number of environments and arbitrary nonlinear mechanisms. Our only constraint is the Gaussianity of the noise terms; however, we propose potential ways to relax this requirement. Of interest on its own, we expand on the well-known duality between independent component analysis (ICA) and causal discovery; recent advancements have shown that nonlinear ICA can be solved from multiple environments, at least as many as the number of sources: we show that the same can be achieved for causal discovery while having access to much less auxiliary information.","lang":"eng"}]},{"type":"journal_article","citation":{"apa":"Bokor Bleile, Y., Yadav, P., Koehl, P., &#38; Rehfeldt, F. (2026). Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population. <i>PLoS Computational Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pcbi.1013890\">https://doi.org/10.1371/journal.pcbi.1013890</a>","ista":"Bokor Bleile Y, Yadav P, Koehl P, Rehfeldt F. 2026. Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population. PLoS Computational Biology. 22, e1013890.","ieee":"Y. Bokor Bleile, P. Yadav, P. Koehl, and F. Rehfeldt, “Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population,” <i>PLoS Computational Biology</i>, vol. 22. Public Library of Science, 2026.","chicago":"Bokor Bleile, Yossi, Pooja Yadav, Patrice Koehl, and Florian Rehfeldt. “Persistence Diagrams as Morphological Signatures of Cells: A Method to Measure and Compare Cells within a Population.” <i>PLoS Computational Biology</i>. Public Library of Science, 2026. <a href=\"https://doi.org/10.1371/journal.pcbi.1013890\">https://doi.org/10.1371/journal.pcbi.1013890</a>.","mla":"Bokor Bleile, Yossi, et al. “Persistence Diagrams as Morphological Signatures of Cells: A Method to Measure and Compare Cells within a Population.” <i>PLoS Computational Biology</i>, vol. 22, e1013890, Public Library of Science, 2026, doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1013890\">10.1371/journal.pcbi.1013890</a>.","short":"Y. Bokor Bleile, P. Yadav, P. Koehl, F. Rehfeldt, PLoS Computational Biology 22 (2026).","ama":"Bokor Bleile Y, Yadav P, Koehl P, Rehfeldt F. Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population. <i>PLoS Computational Biology</i>. 2026;22. doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1013890\">10.1371/journal.pcbi.1013890</a>"},"volume":22,"ddc":["000"],"publication":"PLoS Computational Biology","acknowledgement":"We thank Stephan Huckemann, Katharine Turner, Benjamin Eltzner, Stephan Tillmann, Fariza Rashid, Vanessa Robins, and Lamiae Azizi for many useful discussions at various stages of this project. FR and PY gratefully acknowledge Matthias Weiss (Experimental Physics I, University of Bayreuth, Germany) for granting access to cell culture and laboratories, as well as funding consumables and the fruitful discussion that contributed to this work. For open access purposes, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission.","intvolume":"        22","quality_controlled":"1","language":[{"iso":"eng"}],"DOAJ_listed":"1","doi":"10.1371/journal.pcbi.1013890","day":"28","article_number":"e1013890","date_published":"2026-01-28T00:00:00Z","date_updated":"2026-06-11T11:51:13Z","_id":"21115","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","PlanS_conform":"1","year":"2026","month":"01","publication_identifier":{"issn":["1553-7358"]},"external_id":{"pmid":["41604421"]},"abstract":[{"text":"Quantifying cell morphology is central to understanding cellular regulation, fate, and heterogeneity, yet conventional image-based analyses often struggle with diverse or irregular shapes. We present a computational framework that uses topological data analysis to characterise and compare single-cell morphologies from fluorescence microscopy. Each cell is represented by its contour together with the position of its nucleus, from which we construct a filtration based on a radial distance function and derive a persistence diagram encoding the shape’s topological evolution. The similarity between two cells is quantified using the 2-Wasserstein distance between their diagrams, yielding a shape distance we call the PH distance. We apply this method to two representative experimental systems—primary human mesenchymal stem cells (hMSCs) and HeLa cells—and show that PH distances enable the detection of outliers in those systems, the identification of sub-populations, and the quantification of shape heterogeneity. We benchmark PH against three established contour-based distances (aspect ratio, Fourier descriptors, and elastic shape analysis) and show that PH offers better separation between cell types and greater robustness when clustering heterogeneous populations. Together, these results demonstrate that persistent-homology-based signatures provide a principled and sensitive approach for analysing cell morphology in settings where traditional geometric or image-based descriptors are insufficient.","lang":"eng"}],"file":[{"success":1,"date_created":"2026-02-10T07:13:06Z","access_level":"open_access","checksum":"3899d929ee9be0453c95524e49992d72","creator":"dernst","relation":"main_file","content_type":"application/pdf","file_name":"2026_PloSCompBio_Bleile.pdf","file_id":"21204","file_size":8908746,"date_updated":"2026-02-10T07:13:06Z"}],"pmid":1,"file_date_updated":"2026-02-10T07:13:06Z","article_type":"original","OA_type":"gold","title":"Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population","article_processing_charge":"Yes","oa_version":"Published Version","related_material":{"link":[{"url":"https://github.com/yossibokorbleile/correa","relation":"software"}]},"date_created":"2026-01-30T10:36:32Z","publication_status":"published","status":"public","has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"scopus_import":"1","oa":1,"corr_author":"1","author":[{"last_name":"Bleile","first_name":"Yossi","id":"920a7385-7995-11ef-9bfd-8c434cd8f3c2","orcid":"0000-0002-4861-9174","full_name":"Bleile, Yossi"},{"first_name":"Pooja","last_name":"Yadav","full_name":"Yadav, Pooja"},{"full_name":"Koehl, Patrice","last_name":"Koehl","first_name":"Patrice"},{"full_name":"Rehfeldt, Florian","last_name":"Rehfeldt","first_name":"Florian"}],"department":[{"_id":"HeEd"}],"publisher":"Public Library of Science"},{"author":[{"last_name":"Layana Franco","id":"02814589-eb8f-11eb-b029-a70074f3f18f","first_name":"Lorena Alexandra","full_name":"Layana Franco, Lorena Alexandra","orcid":"0000-0002-1253-6297"},{"full_name":"Toups, Melissa A","orcid":"0000-0002-9752-7380","last_name":"Toups","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","first_name":"Melissa A"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","last_name":"Vicoso","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306"}],"month":"01","corr_author":"1","publisher":"Institute of Science and Technology Austria","department":[{"_id":"BeVi"}],"_id":"21116","has_accepted_license":"1","status":"public","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","date_updated":"2026-02-12T12:58:00Z","oa":1,"year":"2026","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.15479/AT-ISTA-21116","date_created":"2026-01-30T11:04:14Z","oa_version":"Published Version","date_published":"2026-01-02T00:00:00Z","day":"2","title":"Research Data for \"Causes and consequences of sex-chromosome turnovers in Diptera\"","article_processing_charge":"No","file":[{"file_name":"README.txt","content_type":"text/plain","relation":"main_file","creator":"llayanaf","access_level":"open_access","success":1,"date_created":"2026-01-30T11:00:24Z","checksum":"0b79be6229f2ad9ac117ef00fc4f5c0e","date_updated":"2026-01-30T11:00:24Z","file_id":"21117","file_size":1201},{"relation":"main_file","content_type":"application/zip","file_name":"Supplementary_Tables.zip","creator":"llayanaf","checksum":"a3cda72e4177fa1e5d3f0f6a88f8a79b","access_level":"open_access","success":1,"date_created":"2026-01-30T11:00:36Z","date_updated":"2026-01-30T11:00:36Z","file_size":572403,"file_id":"21118"},{"file_id":"21119","file_size":19054553,"date_updated":"2026-01-30T11:00:48Z","access_level":"open_access","date_created":"2026-01-30T11:00:48Z","success":1,"checksum":"efb5b64698d6ca9e7b675204f6fc1c29","content_type":"application/zip","file_name":"Supplementary_Datasets.zip","relation":"main_file","creator":"llayanaf"},{"date_updated":"2026-01-30T11:00:56Z","file_size":4575,"file_id":"21120","creator":"llayanaf","file_name":"Perl_scripts.zip","relation":"main_file","content_type":"application/zip","checksum":"254e050f648e9783ba8fe11adb3b49db","date_created":"2026-01-30T11:00:56Z","success":1,"access_level":"open_access"}],"type":"research_data","citation":{"apa":"Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2026). Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21116\">https://doi.org/10.15479/AT-ISTA-21116</a>","ista":"Layana Franco LA, Toups MA, Vicoso B. 2026. Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21116\">10.15479/AT-ISTA-21116</a>.","ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera.’” Institute of Science and Technology Austria, 2026.","ama":"Layana Franco LA, Toups MA, Vicoso B. Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21116\">10.15479/AT-ISTA-21116</a>","short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, (2026).","mla":"Layana Franco, Lorena Alexandra, et al. <i>Research Data for “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21116\">10.15479/AT-ISTA-21116</a>.","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Research Data for ‘Causes and Consequences of Sex-Chromosome Turnovers in Diptera.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21116\">https://doi.org/10.15479/AT-ISTA-21116</a>."},"abstract":[{"text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analyzed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find that the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on Muller element F (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes.","lang":"eng"}],"keyword":["Schizophora","sex chromosomes","sex-chromosome turnover","Diptera","genomic features","out-of-X movement."],"file_date_updated":"2026-01-30T11:00:56Z"},{"department":[{"_id":"MiSa"}],"publisher":"Association for Computing Machinery","author":[{"first_name":"Laila","last_name":"Elbeheiry","full_name":"Elbeheiry, Laila"},{"last_name":"Sammler","first_name":"Michael Joachim","id":"510d3901-2a03-11ee-914d-d9ae9011f0a7","full_name":"Sammler, Michael Joachim"},{"full_name":"Krebbers, Robbert","first_name":"Robbert","last_name":"Krebbers"},{"full_name":"Dreyer, Derek","last_name":"Dreyer","first_name":"Derek"},{"last_name":"Garg","first_name":"Deepak","full_name":"Garg, Deepak"}],"conference":{"start_date":"2026-01-12","location":"Rennes, France","name":"CPP: Conference on Certified Programs and Proofs","end_date":"2026-01-13"},"scopus_import":"1","oa":1,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","status":"public","oa_version":"Published Version","date_created":"2026-02-01T23:01:43Z","publication_status":"published","title":"A recipe for modular verification of generic tree traversals","article_processing_charge":"No","OA_type":"gold","file_date_updated":"2026-02-16T08:40:29Z","file":[{"content_type":"application/pdf","file_name":"2026_CPP_Elbeheiry.pdf","relation":"main_file","creator":"dernst","access_level":"open_access","date_created":"2026-02-16T08:40:29Z","success":1,"checksum":"7df99991493e907d83a197151f378e3e","date_updated":"2026-02-16T08:40:29Z","file_id":"21225","file_size":811872}],"page":"339-352","abstract":[{"lang":"eng","text":"Data structures based on trees and tree traversals are ubiquitous in computer systems. Many low-level programs, including some implementations of critical systems like page tables and the web browser DOM, rely on generic tree-traversal functions that traverse tree nodes in a pre-determined order, applying a client-provided operation to each visited node. Developing a general approach to specifying and verifying such traversals is tricky since the client-provided per-node operation can be stateful and may potentially depend on or modify the structure of the tree being traversed.\r\nIn this paper, we present a recipe for (semi-)automated verification of such generic, stateful tree traversals. Our recipe is (a) general: it applies to a range of tree traversals, in particular, pre-, post- and in-order depth-first traversals; (b) modular: parts of a traversal’s proof can be reused in verifying other similar traversals; (c) expressive: using the specification of a tree traversal, we can verify clients that use the traversal in a variety of different ways; and (d) automatable: many proof obligations can be discharged automatically.\r\nAt the heart of our recipe is a novel use of tree zippers to represent a logical abstraction of the tree traversal state, and zipper transitions as an abstraction of traversal steps. We realize our recipe in the RefinedC framework in Rocq, which allows us to verify a number of different tree traversals and their clients written in C."}],"publication_identifier":{"isbn":["9798400723414"]},"month":"01","year":"2026","OA_place":"publisher","_id":"21133","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-02-16T08:43:24Z","date_published":"2026-01-08T00:00:00Z","day":"08","doi":"10.1145/3779031.3779110","quality_controlled":"1","language":[{"iso":"eng"}],"publication":"Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs","acknowledgement":"We thank the anonymous reviewers for their insightful suggestions. This research is supported in part by generous awards from Android Security’s ASPIRE program and from Google Research. The third author is supported, in part, by ERC grant COCONUT (grant no. 101171349), funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.","ddc":["000"],"type":"conference","citation":{"apa":"Elbeheiry, L., Sammler, M. J., Krebbers, R., Dreyer, D., &#38; Garg, D. (2026). A recipe for modular verification of generic tree traversals. In <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i> (pp. 339–352). Rennes, France: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3779031.3779110\">https://doi.org/10.1145/3779031.3779110</a>","ista":"Elbeheiry L, Sammler MJ, Krebbers R, Dreyer D, Garg D. 2026. A recipe for modular verification of generic tree traversals. Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs. CPP: Conference on Certified Programs and Proofs, 339–352.","ieee":"L. Elbeheiry, M. J. Sammler, R. Krebbers, D. Dreyer, and D. Garg, “A recipe for modular verification of generic tree traversals,” in <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>, Rennes, France, 2026, pp. 339–352.","ama":"Elbeheiry L, Sammler MJ, Krebbers R, Dreyer D, Garg D. A recipe for modular verification of generic tree traversals. In: <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>. Association for Computing Machinery; 2026:339-352. doi:<a href=\"https://doi.org/10.1145/3779031.3779110\">10.1145/3779031.3779110</a>","short":"L. Elbeheiry, M.J. Sammler, R. Krebbers, D. Dreyer, D. Garg, in:, Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs, Association for Computing Machinery, 2026, pp. 339–352.","chicago":"Elbeheiry, Laila, Michael Joachim Sammler, Robbert Krebbers, Derek Dreyer, and Deepak Garg. “A Recipe for Modular Verification of Generic Tree Traversals.” In <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>, 339–52. Association for Computing Machinery, 2026. <a href=\"https://doi.org/10.1145/3779031.3779110\">https://doi.org/10.1145/3779031.3779110</a>.","mla":"Elbeheiry, Laila, et al. “A Recipe for Modular Verification of Generic Tree Traversals.” <i>Proceedings of the 15th ACM SIGPLAN International Conference on Certified Programs and Proofs</i>, Association for Computing Machinery, 2026, pp. 339–52, doi:<a href=\"https://doi.org/10.1145/3779031.3779110\">10.1145/3779031.3779110</a>."}},{"publication_status":"published","related_material":{"record":[{"id":"21651","status":"public","relation":"dissertation_contains"}]},"oa_version":"Preprint","date_created":"2026-02-01T23:01:43Z","arxiv":1,"article_processing_charge":"No","title":"On the (in)security of Proofs-of-space based longest-chain blockchains","OA_type":"green","page":"127-142","external_id":{"arxiv":["2505.14891"]},"abstract":[{"text":"The Nakamoto consensus protocol underlying the Bitcoin blockchain uses proof of work as a voting mechanism. Honest miners who contribute hashing power towards securing the chain try to extend the longest chain they are aware of. Despite its simplicity, Nakamoto consensus achieves meaningful security guarantees assuming that at any point in time, a majority of the hashing power is controlled by honest parties. This also holds under “resource variability”, i.e., if the total hashing power varies greatly over time.\r\nProofs of space (PoSpace) have been suggested as a more sustainable replacement for proofs of work. Unfortunately, no construction of a “longest-chain” blockchain based on PoSpace, that is secure under dynamic availability, is known. In this work, we prove that without additional assumptions no such protocol exists. We exactly quantify this impossibility result by proving a bound on the length of the fork required for double spending as a function of the adversarial capabilities. This bound holds for any chain selection rule, and we also show a chain selection rule (albeit a very strange one) that almost matches this bound.\r\nThe Nakamoto consensus protocol underlying the Bitcoin blockchain uses proof of work as a voting mechanism. Honest miners who contribute hashing power towards securing the chain try to extend the longest chain they are aware of. Despite its simplicity, Nakamoto consensus achieves meaningful security guarantees assuming that at any point in time, a majority of the hashing power is controlled by honest parties. This also holds under “resource variability”, i.e., if the total hashing power varies greatly over time.\r\n\r\nProofs of space (PoSpace) have been suggested as a more sustainable replacement for proofs of work. Unfortunately, no construction of a “longest-chain” blockchain based on PoSpace, that is secure under dynamic availability, is known. In this work, we prove that without additional assumptions no such protocol exists. We exactly quantify this impossibility result by proving a bound on the length of the fork required for double spending as a function of the adversarial capabilities. This bound holds for any chain selection rule, and we also show a chain selection rule (albeit a very strange one) that almost matches this bound.\r\n\r\nConcretely, we consider a security game in which the honest parties at any point control 0 > 1\r\n times more space than the adversary. The adversary can change the honest space by a factor 1+- E with every block (dynamic availability), and “replotting” the space (which allows answering two challenges using the same space) takes as much time as p blocks.\r\nWe prove that no matter what chain selection rule is used, in this game the adversary can create a fork of length o^2 . p/E that will be picked as the winner by the chain selection rule.\r\nWe also provide an upper bound that matches the lower bound up to a factor o. There exists a chain selection rule (albeit a very strange one) which in the above game requires forks of length at least o . p/E\r\nOur results show the necessity of additional assumptions to create a secure PoSpace based longest-chain blockchain. The Chia network in addition to PoSpace uses a verifiable delay function. Our bounds show that an additional primitive like that is necessary.","lang":"eng"}],"publisher":"Springer Nature","department":[{"_id":"KrPi"}],"corr_author":"1","author":[{"last_name":"Baig","id":"3EDE6DE4-AA5A-11E9-986D-341CE6697425","first_name":"Mirza Ahad","full_name":"Baig, Mirza Ahad"},{"full_name":"Pietrzak, Krzysztof Z","orcid":"0000-0002-9139-1654","last_name":"Pietrzak","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","first_name":"Krzysztof Z"}],"project":[{"grant_number":"F8509","name":"Security and Privacy by Design for Complex Systems","_id":"34a34d57-11ca-11ed-8bc3-a2688a8724e1"}],"alternative_title":["LNCS"],"scopus_import":"1","conference":{"name":"FC: Financial Cryptography and Data Security","end_date":"2025-04-18","start_date":"2025-04-14","location":"Miyakojima, Japan"},"oa":1,"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2505.14891"}],"date_published":"2026-01-01T00:00:00Z","day":"01","doi":"10.1007/978-3-032-07035-7_8","quality_controlled":"1","language":[{"iso":"eng"}],"acknowledgement":"This research was funded in whole or in part by the Austrian Science Fund (FWF) 10.55776/F85.","publication":"29th International Conference on Financial Cryptography and Data Security","intvolume":"     15752","volume":15752,"citation":{"ieee":"M. A. Baig and K. Z. Pietrzak, “On the (in)security of Proofs-of-space based longest-chain blockchains,” in <i>29th International Conference on Financial Cryptography and Data Security</i>, Miyakojima, Japan, 2026, vol. 15752, pp. 127–142.","ama":"Baig MA, Pietrzak KZ. On the (in)security of Proofs-of-space based longest-chain blockchains. In: <i>29th International Conference on Financial Cryptography and Data Security</i>. Vol 15752. Springer Nature; 2026:127-142. doi:<a href=\"https://doi.org/10.1007/978-3-032-07035-7_8\">10.1007/978-3-032-07035-7_8</a>","short":"M.A. Baig, K.Z. Pietrzak, in:, 29th International Conference on Financial Cryptography and Data Security, Springer Nature, 2026, pp. 127–142.","chicago":"Baig, Mirza Ahad, and Krzysztof Z Pietrzak. “On the (in)Security of Proofs-of-Space Based Longest-Chain Blockchains.” In <i>29th International Conference on Financial Cryptography and Data Security</i>, 15752:127–42. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-3-032-07035-7_8\">https://doi.org/10.1007/978-3-032-07035-7_8</a>.","mla":"Baig, Mirza Ahad, and Krzysztof Z. Pietrzak. “On the (in)Security of Proofs-of-Space Based Longest-Chain Blockchains.” <i>29th International Conference on Financial Cryptography and Data Security</i>, vol. 15752, Springer Nature, 2026, pp. 127–42, doi:<a href=\"https://doi.org/10.1007/978-3-032-07035-7_8\">10.1007/978-3-032-07035-7_8</a>.","apa":"Baig, M. A., &#38; Pietrzak, K. Z. (2026). On the (in)security of Proofs-of-space based longest-chain blockchains. In <i>29th International Conference on Financial Cryptography and Data Security</i> (Vol. 15752, pp. 127–142). Miyakojima, Japan: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-032-07035-7_8\">https://doi.org/10.1007/978-3-032-07035-7_8</a>","ista":"Baig MA, Pietrzak KZ. 2026. On the (in)security of Proofs-of-space based longest-chain blockchains. 29th International Conference on Financial Cryptography and Data Security. FC: Financial Cryptography and Data Security, LNCS, vol. 15752, 127–142."},"type":"conference","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783032070340"]},"month":"01","year":"2026","OA_place":"repository","_id":"21134","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-04-15T08:45:18Z"},{"OA_type":"green","publication_status":"published","date_created":"2026-02-01T23:01:44Z","related_material":{"link":[{"url":"https://github.com/jakobtroidl/niiv-miccai","relation":"software"}]},"oa_version":"Preprint","article_processing_charge":"No","title":"niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction","page":"257-267","abstract":[{"text":"Three-dimensional (3D) microscopy data is often anisotropic with significantly lower resolution (up to 8x) along the z axis than along the xy axes. Computationally generating plausible isotropic resolution from anisotropic imaging data would benefit the visual analysis of large-scale volumes. This paper proposes niiv, a self-supervised method for isotropic reconstruction of 3D microscopy data that can quickly produce images at arbitrary output resolutions. The representation embeds a learned latent code within a neural field that describes the implicit higher-resolution isotropic image region. We use an attention-guided latent interpolation approach, which allows flexible information exchange over a local latent neighborhood. Under isotropic volume assumptions, we self-supervise this representation on low-/high-resolution lateral image pairs to reconstruct an isotropic volume from low-resolution axial images. We evaluate our method on simulated and real anisotropic electron (EM) and light microscopy (LM) data. Compared to diffusion-based baselines, niiv shows improved reconstruction quality (+1 dB PSNR) and is over three orders of magnitude faster (1,000x) to infer. Specifically, niiv reconstructs a 128^3 voxel volume in 2/10th of a second, renderable at varying (continuous) high resolutions for display. Our code is available at https://github.com/jakobtroidl/niiv-miccai.","lang":"eng"}],"author":[{"full_name":"Troidl, Jakob","last_name":"Troidl","first_name":"Jakob"},{"full_name":"Liang, Yiqing","first_name":"Yiqing","last_name":"Liang"},{"full_name":"Beyer, Johanna","first_name":"Johanna","last_name":"Beyer"},{"orcid":"0000-0002-7667-6854","full_name":"Tavakoli, Mojtaba","last_name":"Tavakoli","first_name":"Mojtaba","id":"3A0A06F4-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","first_name":"Johann G","last_name":"Danzl"},{"full_name":"Hadwiger, Markus","first_name":"Markus","last_name":"Hadwiger"},{"full_name":"Pfister, Hanspeter","first_name":"Hanspeter","last_name":"Pfister"},{"last_name":"Tompkin","first_name":"James","full_name":"Tompkin, James"}],"alternative_title":["LNCS"],"department":[{"_id":"JoDa"}],"publisher":"Springer Nature","status":"public","scopus_import":"1","conference":{"start_date":"2025-09-23","location":"Daejeon, South Korea","end_date":"2025-09-23","name":"EMA4MICCAI: Efficient Medical Artificial Intelligence"},"oa":1,"doi":"10.1007/978-3-032-13961-0_26","main_file_link":[{"url":"https://doi.org/10.1101/2024.09.07.611785","open_access":"1"}],"date_published":"2026-01-03T00:00:00Z","day":"03","volume":16318,"type":"conference","citation":{"ista":"Troidl J, Liang Y, Beyer J, Tavakoli M, Danzl JG, Hadwiger M, Pfister H, Tompkin J. 2026. niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction. 1st International Workshop on Efficient Medical Artificial Intelligence. EMA4MICCAI: Efficient Medical Artificial Intelligence, LNCS, vol. 16318, 257–267.","apa":"Troidl, J., Liang, Y., Beyer, J., Tavakoli, M., Danzl, J. G., Hadwiger, M., … Tompkin, J. (2026). niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction. In <i>1st International Workshop on Efficient Medical Artificial Intelligence</i> (Vol. 16318, pp. 257–267). Daejeon, South Korea: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">https://doi.org/10.1007/978-3-032-13961-0_26</a>","short":"J. Troidl, Y. Liang, J. Beyer, M. Tavakoli, J.G. Danzl, M. Hadwiger, H. Pfister, J. Tompkin, in:, 1st International Workshop on Efficient Medical Artificial Intelligence, Springer Nature, 2026, pp. 257–267.","ama":"Troidl J, Liang Y, Beyer J, et al. niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction. In: <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>. Vol 16318. Springer Nature; 2026:257-267. doi:<a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">10.1007/978-3-032-13961-0_26</a>","chicago":"Troidl, Jakob, Yiqing Liang, Johanna Beyer, Mojtaba Tavakoli, Johann G Danzl, Markus Hadwiger, Hanspeter Pfister, and James Tompkin. “Niiv: Interactive Self-Supervised Neural Implicit Isotropic Volume Reconstruction.” In <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>, 16318:257–67. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">https://doi.org/10.1007/978-3-032-13961-0_26</a>.","mla":"Troidl, Jakob, et al. “Niiv: Interactive Self-Supervised Neural Implicit Isotropic Volume Reconstruction.” <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>, vol. 16318, Springer Nature, 2026, pp. 257–67, doi:<a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">10.1007/978-3-032-13961-0_26</a>.","ieee":"J. Troidl <i>et al.</i>, “niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction,” in <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>, Daejeon, South Korea, 2026, vol. 16318, pp. 257–267."},"quality_controlled":"1","language":[{"iso":"eng"}],"publication":"1st International Workshop on Efficient Medical Artificial Intelligence","acknowledgement":"This work was supported by NIH grants 1U01NS132158 and R01HD104969. We thank the reviewers for their constructive feedback.","intvolume":"     16318","month":"01","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783032139603"]},"_id":"21135","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-02-16T08:50:50Z","year":"2026","OA_place":"repository"},{"license":"https://creativecommons.org/licenses/by-sa/4.0/","file":[{"file_name":"cells-main.zip","relation":"main_file","content_type":"application/zip","creator":"snaik","title":"Cell git repository","checksum":"5d1fda7e410f24c311fcf6bcf725698f","access_level":"open_access","date_created":"2026-03-16T11:51:10Z","date_updated":"2026-03-16T11:51:10Z","description":"Python3 library written in C++20 to integrate vertex models. Please read the readme at https://github.com/yketa/cells/blob/main/README.md for detailed instructions for installation and usage of the code in this repository. 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(2026). Data associated with Keratins coordinate tissue spreading . Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21137\">https://doi.org/10.15479/AT-ISTA-21137</a>","ista":"Naik S. 2026. Data associated with Keratins coordinate tissue spreading , Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21137\">10.15479/AT-ISTA-21137</a>.","ieee":"S. Naik, “Data associated with Keratins coordinate tissue spreading .” Institute of Science and Technology Austria, 2026.","mla":"Naik, Suyash. <i>Data Associated with Keratins Coordinate Tissue Spreading </i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21137\">10.15479/AT-ISTA-21137</a>.","chicago":"Naik, Suyash. “Data Associated with Keratins Coordinate Tissue Spreading .” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21137\">https://doi.org/10.15479/AT-ISTA-21137</a>.","ama":"Naik S. Data associated with Keratins coordinate tissue spreading . 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21137\">10.15479/AT-ISTA-21137</a>","short":"S. Naik, (2026)."},"acknowledgement":"We thank all members of the Heisenberg, Henkes, and Hannezo groups for their support. We are also grateful to the Imaging and Optics, Scientific Computing, Life Science Support, and Cryo-Electron Microscopy facilities at ISTA for their technical assistance and support. Numerical simulations were performed using the computational resources from Lorentz Institute and the Academic Leiden Interdisciplinary Cluster Environment (ALICE) provided by Leiden University, and from PMMH provided by Sorbonne Université. S.N has received funding from European Union’s Horizon 2020 research and innovation programme (grant agreement No. 665385). This work was supported by the Austrian Science Fund (FWF) under projects PAT5044023 and W1250 awarded to C.-P.H.","doi":"10.15479/AT-ISTA-21137","day":"24","date_published":"2026-03-24T00:00:00Z","date_updated":"2026-06-10T09:44:10Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","_id":"21137","OA_place":"repository","year":"2026","acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"month":"3","ec_funded":1},{"date_published":"2026-01-07T00:00:00Z","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2409.20314","open_access":"1"}],"day":"07","doi":"10.1137/1.9781611978971.148","language":[{"iso":"eng"}],"quality_controlled":"1","publication":"Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms","citation":{"chicago":"Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing Forests in Graphs and Related Problems.” In <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, 4023–42. Society for Industrial and Applied Mathematics, 2026. <a href=\"https://doi.org/10.1137/1.9781611978971.148\">https://doi.org/10.1137/1.9781611978971.148</a>.","mla":"Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing Forests in Graphs and Related Problems.” <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Society for Industrial and Applied Mathematics, 2026, pp. 4023–42, doi:<a href=\"https://doi.org/10.1137/1.9781611978971.148\">10.1137/1.9781611978971.148</a>.","short":"P. Arkhipov, V. Kolmogorov, in:, Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics, 2026, pp. 4023–4042.","ama":"Arkhipov P, Kolmogorov V. Faster algorithms for packing forests in graphs and related problems. In: <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>. Society for Industrial and Applied Mathematics; 2026:4023-4042. doi:<a href=\"https://doi.org/10.1137/1.9781611978971.148\">10.1137/1.9781611978971.148</a>","ieee":"P. Arkhipov and V. Kolmogorov, “Faster algorithms for packing forests in graphs and related problems,” in <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Vancouver, Canada, 2026, pp. 4023–4042.","ista":"Arkhipov P, Kolmogorov V. 2026. Faster algorithms for packing forests in graphs and related problems. Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 4023–4042.","apa":"Arkhipov, P., &#38; Kolmogorov, V. (2026). Faster algorithms for packing forests in graphs and related problems. In <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i> (pp. 4023–4042). Vancouver, Canada: Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/1.9781611978971.148\">https://doi.org/10.1137/1.9781611978971.148</a>"},"type":"conference","publication_identifier":{"eisbn":["9781611978971"]},"month":"01","year":"2026","OA_place":"repository","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21140","date_updated":"2026-02-16T09:18:33Z","publication_status":"published","oa_version":"Preprint","date_created":"2026-02-05T10:51:34Z","title":"Faster algorithms for packing forests in graphs and related problems","article_processing_charge":"No","arxiv":1,"OA_type":"green","external_id":{"arxiv":["2409.20314"]},"abstract":[{"lang":"eng","text":"We consider several problems related to packing forests in graphs. The first one is to find k edge-disjoint forests in a directed graph G of maximal size such that the indegree of each vertex in these forests is at most k. We describe a min-max characterization for this problem and show that it can be solved in almost linear time for fixed k, extending the algorithm of [Gabow, 1995]. Specifically, the complexity is O(kδm log n), where n, m are the number of vertices and edges in G respectively, and δ = max{1, k − kG}, where kG is the edge connectivity of the graph. Using our solution to this problem, we improve complexities for two existing applications:(1) k-forest problem: find k forests in an undirected graph G maximizing the number of edges in their union. We show how to solve this problem in O(k3 min{kn, m} log2 n + k · MAXFLOW(m, m) log n) time, breaking the Ok(n3/2) complexity barrier of previously known approaches.(2) Directed edge-connectivity augmentation problem: find a smallest set of directed edges whose addition to the given directed graph makes it strongly k-connected. We improve the deterministic complexity for this problem from O(kδ(m + δn) log n) [Gabow, STOC 1994] to O(kδm log n). A similar approach with the same complexity also works for the undirected version of the problem."}],"page":"4023-4042","publisher":"Society for Industrial and Applied Mathematics","department":[{"_id":"VlKo"}],"author":[{"full_name":"Arkhipov, Pavel","last_name":"Arkhipov","first_name":"Pavel","id":"b25f2ab2-1fed-11ee-8599-fe02d211784f"},{"full_name":"Kolmogorov, Vladimir","last_name":"Kolmogorov","first_name":"Vladimir","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87"}],"corr_author":"1","oa":1,"conference":{"end_date":"2026-01-14","name":"SODA: Symposium on Discrete Algorithms","location":"Vancouver, Canada","start_date":"2026-01-11"},"status":"public"},{"ddc":["530"],"volume":136,"type":"journal_article","citation":{"ieee":"M. Hrast, G. Koutentakis, M. Maslov, and M. Lemeshko, “Bottom-up analysis of rovibrational helical dichroism,” <i>Physical Review Letters</i>, vol. 136, no. 5. American Physical Society, 2026.","mla":"Hrast, Mateja, et al. “Bottom-up Analysis of Rovibrational Helical Dichroism.” <i>Physical Review Letters</i>, vol. 136, no. 5, 053204, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/fkf1-1jml\">10.1103/fkf1-1jml</a>.","chicago":"Hrast, Mateja, Georgios Koutentakis, Mikhail Maslov, and Mikhail Lemeshko. “Bottom-up Analysis of Rovibrational Helical Dichroism.” <i>Physical Review Letters</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/fkf1-1jml\">https://doi.org/10.1103/fkf1-1jml</a>.","ama":"Hrast M, Koutentakis G, Maslov M, Lemeshko M. Bottom-up analysis of rovibrational helical dichroism. <i>Physical Review Letters</i>. 2026;136(5). doi:<a href=\"https://doi.org/10.1103/fkf1-1jml\">10.1103/fkf1-1jml</a>","short":"M. Hrast, G. Koutentakis, M. Maslov, M. Lemeshko, Physical Review Letters 136 (2026).","apa":"Hrast, M., Koutentakis, G., Maslov, M., &#38; Lemeshko, M. (2026). Bottom-up analysis of rovibrational helical dichroism. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/fkf1-1jml\">https://doi.org/10.1103/fkf1-1jml</a>","ista":"Hrast M, Koutentakis G, Maslov M, Lemeshko M. 2026. Bottom-up analysis of rovibrational helical dichroism. Physical Review Letters. 136(5), 053204."},"language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"       136","publication":"Physical Review Letters","acknowledgement":"This research was funded in whole or in part by the Austrian Science Fund (FWF) [10.55776/F1004].","doi":"10.1103/fkf1-1jml","article_number":"053204","date_published":"2026-02-05T00:00:00Z","day":"05","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21149","date_updated":"2026-02-10T11:30:37Z","year":"2026","PlanS_conform":"1","OA_place":"publisher","month":"02","publication_identifier":{"eissn":["1079-7114"],"issn":["0031-9007"]},"file":[{"relation":"main_file","content_type":"application/pdf","file_name":"2026_PhysicalReviewLetters_Hrast.pdf","creator":"dernst","checksum":"805c929fff9fd4d0e733293eaace67b8","access_level":"open_access","success":1,"date_created":"2026-02-10T11:25:46Z","date_updated":"2026-02-10T11:25:46Z","file_size":511312,"file_id":"21210"}],"external_id":{"arxiv":["2505.16393"]},"abstract":[{"lang":"eng","text":"We present a general theoretical framework for helical dichroism (HD), establishing an explicit link between chiral resolution and orbital angular momentum (OAM) exchange in light–matter interaction. Tracing microscopic mechanisms of the OAM transfer, we derive rotational selection rules, which establish that HD emerges only from the spin–orbit coupling of light, even for beams without the far-field OAM. Our findings refine the conditions for observing HD, provide a tool to re-examine the outcome of prior experiments, and guide future designs for chiral sensing with structured light."}],"article_type":"original","file_date_updated":"2026-02-10T11:25:46Z","issue":"5","OA_type":"hybrid","publication_status":"published","oa_version":"Published Version","date_created":"2026-02-06T10:53:17Z","title":"Bottom-up analysis of rovibrational helical dichroism","article_processing_charge":"Yes (via OA deal)","arxiv":1,"status":"public","has_accepted_license":"1","oa":1,"scopus_import":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"project":[{"_id":"7c040762-9f16-11ee-852c-dd79eeee4ab3","grant_number":"F100403","name":"Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions"}],"author":[{"last_name":"Hrast","id":"48dbb294-2a9c-11ef-905d-f56be71f0e5d","first_name":"Mateja","full_name":"Hrast, Mateja"},{"full_name":"Koutentakis, Georgios","last_name":"Koutentakis","id":"d7b23d3a-9e21-11ec-b482-f76739596b95","first_name":"Georgios"},{"first_name":"Mikhail","id":"2E65BB0E-F248-11E8-B48F-1D18A9856A87","last_name":"Maslov","orcid":"0000-0003-4074-2570","full_name":"Maslov, Mikhail"},{"first_name":"Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","last_name":"Lemeshko","orcid":"0000-0002-6990-7802","full_name":"Lemeshko, Mikhail"}],"corr_author":"1","department":[{"_id":"MiLe"}],"publisher":"American Physical Society"},{"doi":"10.1038/s41467-025-67734-0","DOAJ_listed":"1","date_published":"2026-01-27T00:00:00Z","article_number":"999","day":"27","volume":17,"ddc":["580"],"type":"journal_article","citation":{"ista":"Yang P, Liu Y, Dong Q, Miao Y, Zhang J, Xu S, Zhao H, Niu Y, Zhang X, Xu Y, Guo Z, Xing L, Chong K. 2026. O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. Nature Communications. 17, 999.","apa":"Yang, P., Liu, Y., Dong, Q., Miao, Y., Zhang, J., Xu, S., … Chong, K. (2026). O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-67734-0\">https://doi.org/10.1038/s41467-025-67734-0</a>","chicago":"Yang, Pengfang, Yangyang Liu, Qi Dong, Yuting Miao, Jianlong Zhang, Shujuan Xu, Hong Zhao, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10 Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-025-67734-0\">https://doi.org/10.1038/s41467-025-67734-0</a>.","mla":"Yang, Pengfang, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10 Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>, vol. 17, 999, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-025-67734-0\">10.1038/s41467-025-67734-0</a>.","short":"P. Yang, Y. Liu, Q. Dong, Y. Miao, J. Zhang, S. Xu, H. Zhao, Y. Niu, X. Zhang, Y. Xu, Z. Guo, L. Xing, K. Chong, Nature Communications 17 (2026).","ama":"Yang P, Liu Y, Dong Q, et al. O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-025-67734-0\">10.1038/s41467-025-67734-0</a>","ieee":"P. Yang <i>et al.</i>, “O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026."},"quality_controlled":"1","language":[{"iso":"eng"}],"publication":"Nature Communications","acknowledgement":"This work was supported by the Basic Science Center Project of National Natural Science Foundation of China (32388201) to K.C and the National Natural Science Foundation of China (31970331) to L.X. We thank Dr. Zhuang Lu, Dr. Bin Han and Ms. Jingquan Li (Plant Science Facility of the Institute of Botany, Chinese Academy of Sciences) for their technical assistance in LC-MS/MS assay, small molecule compound analysis and the subcellular localization assay, respectively. We thank Dr. Wei Luo and Dr. Dongfeng Liu for helpful discussions.","intvolume":"        17","month":"01","publication_identifier":{"eissn":["2041-1723"]},"_id":"21158","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-02-12T14:34:24Z","year":"2026","OA_place":"publisher","PlanS_conform":"1","OA_type":"gold","oa_version":"Published Version","publication_status":"published","date_created":"2026-02-08T23:02:48Z","title":"O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering","article_processing_charge":"Yes","file":[{"creator":"dernst","relation":"main_file","file_name":"2026_NatureComm_Yang.pdf","content_type":"application/pdf","success":1,"date_created":"2026-02-12T14:33:14Z","access_level":"open_access","checksum":"9ae170ec70ba1ab56b6f1ffe67d1de7f","date_updated":"2026-02-12T14:33:14Z","file_id":"21223","file_size":4685882}],"pmid":1,"external_id":{"pmid":["41455723"]},"abstract":[{"text":"Vernalization-regulated flowering is vital for wheat yield and geographical distribution, and the diversity of flowering time genes is essential for the breeding of climate-resilient varieties. Sugars have long been recognized in regulating flowering; however, the intrinsic connection between carbohydrate metabolism and vernalization response remains largely unexplored. Here, we identify a fructose 1,6-bisphosphate aldolase (FBA) encoding gene, HtL1/FBA10, as a modulator of heading time variation based on a genome-wide association study utilizing wheat core germplasm collections. Evolutionary analysis shows a decrease in the proportion of haplotype-2 of HtL1, which is linked to delayed flowering, in Chinese and American wheat varieties compared to landraces. Vernalization reduces HtL1/FBA10 phosphorylation levels and  increases  its O-GlcNAcylation, which in turn enhances its enzymatic activity and facilitates VERNALIZATION 1 (VRN1) transcription by regulating histone acetylation at the VRN1 locus. Our findings provide mechanistic insights into the interplay between glucose metabolism and the epigenetic regulation of vernalization in winter wheat.","lang":"eng"}],"file_date_updated":"2026-02-12T14:33:14Z","article_type":"original","author":[{"full_name":"Yang, Pengfang","last_name":"Yang","first_name":"Pengfang"},{"full_name":"Liu, Yangyang","first_name":"Yangyang","last_name":"Liu"},{"full_name":"Dong, Qi","first_name":"Qi","last_name":"Dong"},{"last_name":"Miao","first_name":"Yuting","full_name":"Miao, Yuting"},{"first_name":"Jianlong","last_name":"Zhang","full_name":"Zhang, Jianlong"},{"last_name":"Xu","id":"9724dd9d-f591-11ee-bd51-e97ed0652286","first_name":"Shujuan","full_name":"Xu, Shujuan"},{"first_name":"Hong","last_name":"Zhao","full_name":"Zhao, Hong"},{"first_name":"Yuda","last_name":"Niu","full_name":"Niu, Yuda"},{"full_name":"Zhang, Xueyong","first_name":"Xueyong","last_name":"Zhang"},{"full_name":"Xu, Yunyuan","last_name":"Xu","first_name":"Yunyuan"},{"full_name":"Guo, Zifeng","last_name":"Guo","first_name":"Zifeng"},{"first_name":"Lijing","last_name":"Xing","full_name":"Xing, Lijing"},{"first_name":"Kang","last_name":"Chong","full_name":"Chong, Kang"}],"department":[{"_id":"XiFe"}],"publisher":"Springer Nature","has_accepted_license":"1","status":"public","scopus_import":"1","oa":1,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"}},{"article_type":"original","file_date_updated":"2026-02-16T09:52:38Z","external_id":{"arxiv":["2408.09589"]},"abstract":[{"text":"One of the foundational theorems of extremal graph theory is Dirac’s theorem, which\r\nsays that if an n-vertex graph G has minimum degree at least n/2, then G has a\r\nHamilton cycle, and therefore a perfect matching (if n is even). Later work by Sárközy,\r\nSelkow and Szemerédi showed that in fact Dirac graphs have many Hamilton cycles\r\nand perfect matchings, culminating in a result of Cuckler and Kahn that gives a precise\r\ndescription of the numbers of Hamilton cycles and perfect matchings in a Dirac graph\r\nG (in terms of an entropy-like parameter of G). In this paper we extend Cuckler\r\nand Kahn’s result to perfect matchings in hypergraphs. For positive integers d < k,\r\nand for n divisible by k, let md (k, n) be the minimum d-degree that ensures the\r\nexistence of a perfect matching in an n-vertex k-uniform hypergraph. In general, it is\r\nan open question to determine (even asymptotically) the values of md (k, n), but we are\r\nnonetheless able to prove an analogue of the Cuckler–Kahn theorem, showing that if\r\nan n-vertex k-uniform hypergraph G has minimum d-degree at least (1+γ )md (k, n)\r\n(for any constantγ > 0), then the number of perfect matchings in G is controlled by\r\nan entropy-like parameter of G. This strengthens cruder estimates arising from work\r\nof Kang–Kelly–Kühn–Osthus–Pfenninger and Pham–Sah–Sawhney–Simkin.","lang":"eng"}],"file":[{"date_updated":"2026-02-16T09:52:38Z","file_size":539646,"file_id":"21228","creator":"dernst","file_name":"2026_Combinatorica_Kwan.pdf","relation":"main_file","content_type":"application/pdf","checksum":"47b0031d90b0e6b9a843f422a1486089","success":1,"date_created":"2026-02-16T09:52:38Z","access_level":"open_access"}],"title":"Counting perfect matchings in Dirac hypergraphs","article_processing_charge":"Yes (via OA deal)","arxiv":1,"oa_version":"Published Version","publication_status":"published","date_created":"2026-02-08T23:02:49Z","OA_type":"hybrid","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa":1,"scopus_import":"1","has_accepted_license":"1","status":"public","publisher":"Springer Nature","department":[{"_id":"MaKw"},{"_id":"MoHe"}],"author":[{"orcid":"0000-0002-4003-7567","full_name":"Kwan, Matthew Alan","first_name":"Matthew Alan","id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","last_name":"Kwan"},{"full_name":"Safavi Hemami, Roodabeh","last_name":"Safavi Hemami","first_name":"Roodabeh","id":"72ed2640-8972-11ed-ae7b-f9c81ec75154"},{"orcid":"0000-0002-2856-767X","full_name":"Wang, Yiting","id":"1917d194-076e-11ed-97cd-837255f88785","first_name":"Yiting","last_name":"Wang"}],"corr_author":"1","intvolume":"        46","acknowledgement":"We would like to thank the referees for a number of helpful comments and suggestions, which have substantially improved the paper. Open access funding provided by Institute of Science and Technology (IST Austria).","publication":"Combinatorica","language":[{"iso":"eng"}],"quality_controlled":"1","citation":{"ieee":"M. A. Kwan, R. Safavi Hemami, and Y. Wang, “Counting perfect matchings in Dirac hypergraphs,” <i>Combinatorica</i>, vol. 46. Springer Nature, 2026.","mla":"Kwan, Matthew Alan, et al. “Counting Perfect Matchings in Dirac Hypergraphs.” <i>Combinatorica</i>, vol. 46, 5, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1007/s00493-025-00194-8\">10.1007/s00493-025-00194-8</a>.","chicago":"Kwan, Matthew Alan, Roodabeh Safavi Hemami, and Yiting Wang. “Counting Perfect Matchings in Dirac Hypergraphs.” <i>Combinatorica</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/s00493-025-00194-8\">https://doi.org/10.1007/s00493-025-00194-8</a>.","ama":"Kwan MA, Safavi Hemami R, Wang Y. Counting perfect matchings in Dirac hypergraphs. <i>Combinatorica</i>. 2026;46. doi:<a href=\"https://doi.org/10.1007/s00493-025-00194-8\">10.1007/s00493-025-00194-8</a>","short":"M.A. Kwan, R. Safavi Hemami, Y. Wang, Combinatorica 46 (2026).","apa":"Kwan, M. A., Safavi Hemami, R., &#38; Wang, Y. (2026). Counting perfect matchings in Dirac hypergraphs. <i>Combinatorica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00493-025-00194-8\">https://doi.org/10.1007/s00493-025-00194-8</a>","ista":"Kwan MA, Safavi Hemami R, Wang Y. 2026. Counting perfect matchings in Dirac hypergraphs. Combinatorica. 46, 5."},"type":"journal_article","ddc":["510"],"volume":46,"day":"01","date_published":"2026-02-01T00:00:00Z","article_number":"5","doi":"10.1007/s00493-025-00194-8","PlanS_conform":"1","OA_place":"publisher","year":"2026","date_updated":"2026-02-16T09:55:17Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21159","publication_identifier":{"eissn":["1439-6912"],"issn":["0209-9683"]},"month":"02"},{"day":"19","date_published":"2026-02-19T00:00:00Z","doi":"10.15479/AT-ISTA-21174","acknowledgement":"Thanks to Salvatore Bagiante, Evgeniia Volobueva, Lubuna Shafeek, Ali Bangura and Zoltan Kollo.","citation":{"mla":"Modic, Kimberly A. <i>Research Data for “Giant Transverse Magnetic Fluctuations at the Edge of Re-Entrant Superconductivity in UTe2.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21174\">10.15479/AT-ISTA-21174</a>.","chicago":"Modic, Kimberly A. “Research Data for ‘Giant Transverse Magnetic Fluctuations at the Edge of Re-Entrant Superconductivity in UTe2.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21174\">https://doi.org/10.15479/AT-ISTA-21174</a>.","short":"K.A. Modic, (2026).","ama":"Modic KA. Research data for “Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21174\">10.15479/AT-ISTA-21174</a>","ieee":"K. A. Modic, “Research data for ‘Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2.’” Institute of Science and Technology Austria, 2026.","ista":"Modic KA. 2026. Research data for ‘Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21174\">10.15479/AT-ISTA-21174</a>.","apa":"Modic, K. A. (2026). Research data for “Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21174\">https://doi.org/10.15479/AT-ISTA-21174</a>"},"type":"research_data","ddc":["530"],"acknowledged_ssus":[{"_id":"NanoFab"}],"month":"02","OA_place":"repository","year":"2026","date_updated":"2026-05-11T06:35:59Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","_id":"21174","article_processing_charge":"Yes","title":"Research data for \"Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2\"","oa_version":"Published Version","date_created":"2026-02-09T12:04:20Z","related_material":{"link":[{"url":"https://arxiv.org/pdf/2506.08984","relation":"preprint"}],"record":[{"id":"21845","status":"public","relation":"used_in_publication"}]},"OA_type":"free access","file_date_updated":"2026-02-19T07:39:07Z","keyword":["transverse magnetic susceptibility","magnetotropic","superconductivity","magnetic fluctuations"],"abstract":[{"text":"UTe2 exhibits the remarkable phenomenon of re-entrant superconductivity, whereby the zero-resistance state reappears above 40 tesla after being suppressed with a field of around 10 tesla. One potential pairing mechanism, invoked in the related re-entrant superconductors UCoGe and URhGe, involves transverse fluctuations of a ferromagnetic order parameter. However, the requisite ferromagnetic order - present in both UCoGe and URhGe - is absent in UTe2, and magnetization measurements show no sign of strong fluctuations. Here, we measure the magnetotropic susceptibility of UTe2 across two field-angle planes. This quantity is sensitive to the magnetic susceptibility in a direction transverse to the applied magnetic field - a quantity that is not accessed in conventional magnetization measurements. We observe a very large decrease in the magnetotropic susceptibility over a broad range of field orientations, indicating a large increase in the transverse magnetic susceptibility. The three superconducting phases of UTe2, including the high-field re-entrant phase, surround this region of enhanced susceptibility in the field-angle phase diagram. The strongest transverse susceptibility is found near the critical end point of the high-field metamagnetic transition, suggesting that quantum critical fluctuations of a field-induced magnetic order parameter may be responsible for the large transverse susceptibility, and may provide a pairing mechanism for field-induced superconductivity in UTe2.","lang":"eng"}],"file":[{"checksum":"53157d908fba663275c2b8dc6ee84fdb","date_created":"2026-02-19T07:38:15Z","success":1,"access_level":"open_access","creator":"kmodic","content_type":"text/plain","relation":"main_file","file_name":"README.txt","file_size":1347,"file_id":"21332","date_updated":"2026-02-19T07:38:15Z"},{"date_updated":"2026-02-19T07:39:03Z","file_id":"21333","file_size":534853,"creator":"kmodic","content_type":"application/zip","file_name":"processed_data_bc_plane_Fig2d.zip","relation":"main_file","success":1,"date_created":"2026-02-19T07:39:03Z","access_level":"open_access","checksum":"b2c8ca5620ee9c181a42082068d3d73c"},{"access_level":"open_access","date_created":"2026-02-19T07:39:07Z","success":1,"checksum":"976bf113da4b1133313f0b292e71289f","content_type":"application/zip","relation":"main_file","file_name":"processed_data_ac_plane_Fig2c.zip","creator":"kmodic","file_id":"21334","file_size":427144,"date_updated":"2026-02-19T07:39:07Z"}],"publisher":"Institute of Science and Technology Austria","department":[{"_id":"KiMo"}],"project":[{"grant_number":"101078696","name":"Gaining leverage with spin liquids and superconductors","_id":"bd968c70-d553-11ed-ba76-cde40b0aba64"}],"author":[{"last_name":"Modic","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425","first_name":"Kimberly A","orcid":"0000-0001-9760-3147","full_name":"Modic, Kimberly A"}],"corr_author":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa":1,"contributor":[{"contributor_type":"project_member","last_name":"Zambra","id":"467ed36b-dc96-11ea-b7c8-b043a380b282","first_name":"Valeska","orcid":"0000-0002-8806-5719"}],"status":"public","has_accepted_license":"1"},{"ddc":["570"],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","abstract":[{"text":"Malignant glioma is incurable. Using a mouse genetic mosaic system to generate sporadic Trp53,Nf1-null OPCs, we previously identified oligodendrocyte precursor cell (OPC) as a cell-of-origin of glioma. Here, we report that pre-malignant Trp53,Nf1-null OPCs outcompete wildtype counterparts during their expansion. Blocking competition by mutating/strengthening wildtype OPCs impeded both pre-malignant progression and malignant expansion of glioma.\r\n\r\n“In-tissue” phosphoproteomic profiling revealed an enrichment of phosphopeptides related to RNA splicing and protein translation at the peak of cell competition, suggesting that competitiveness may stem from unique protein species. Among candidates was mTORC1, whose pharmacological inhibition or genetic disruption resulted in a loss of competitiveness in our mouse model. Finally, analysis of patient biopsies and interrogating the role of individual gliomagenic mutations in OPC competition supported its relevance in human gliomas. Together, these findings identified the driving role of competitive interactions among OPCs in gliomagenesis, and suggest unconventional therapeutic strategies to target this process.","lang":"eng"}],"citation":{"apa":"Jiang, Y., Ahn, R., Huang, A., Gonzalez, P. P., Kim, J., Zhang, G., … Zong, H. (2026). Critical role of cell competition in gliomagenesis. <i>bioRxiv</i>. <a href=\"https://doi.org/10.64898/2026.01.15.699808\">https://doi.org/10.64898/2026.01.15.699808</a>","ista":"Jiang Y, Ahn R, Huang A, Gonzalez PP, Kim J, Zhang G, Liu Z, He Z, Dudley L, Patel KS, Dzhivhuho GA, Crowl S, Przanowski P, Camacho LQ, Hao S, Zeng J, Hippenmeyer S, Fallahi-Sichani M, Janes KA, Naegle KM, Hammarskjold M-L, Goldman SA, Kornblum HI, Yao M, White F, Zong H. 2026. Critical role of cell competition in gliomagenesis. bioRxiv, <a href=\"https://doi.org/10.64898/2026.01.15.699808\">10.64898/2026.01.15.699808</a>.","ieee":"Y. Jiang <i>et al.</i>, “Critical role of cell competition in gliomagenesis,” <i>bioRxiv</i>. 2026.","short":"Y. Jiang, R. Ahn, A. Huang, P.P. Gonzalez, J. Kim, G. Zhang, Z. Liu, Z. He, L. Dudley, K.S. Patel, G.A. Dzhivhuho, S. Crowl, P. Przanowski, L.Q. Camacho, S. Hao, J. Zeng, S. Hippenmeyer, M. Fallahi-Sichani, K.A. Janes, K.M. Naegle, M.-L. Hammarskjold, S.A. Goldman, H.I. Kornblum, M. Yao, F. White, H. Zong, BioRxiv (2026).","ama":"Jiang Y, Ahn R, Huang A, et al. Critical role of cell competition in gliomagenesis. <i>bioRxiv</i>. 2026. doi:<a href=\"https://doi.org/10.64898/2026.01.15.699808\">10.64898/2026.01.15.699808</a>","chicago":"Jiang, Ying, Ryuhjin Ahn, Arthur Huang, Phillippe P. Gonzalez, Jungeun Kim, Guoxin Zhang, Zihao Liu, et al. “Critical Role of Cell Competition in Gliomagenesis.” <i>BioRxiv</i>, 2026. <a href=\"https://doi.org/10.64898/2026.01.15.699808\">https://doi.org/10.64898/2026.01.15.699808</a>.","mla":"Jiang, Ying, et al. “Critical Role of Cell Competition in Gliomagenesis.” <i>BioRxiv</i>, 2026, doi:<a href=\"https://doi.org/10.64898/2026.01.15.699808\">10.64898/2026.01.15.699808</a>."},"type":"preprint","language":[{"iso":"eng"}],"acknowledgement":"We thank Dr. Wenjie Liu for providing critical feedback on the manuscript. We also thank Dr.\r\nPat Pramoonjago at the Biorepository and Tissue Research Facility, and Hope Davis at the\r\nvivarium for their assistance on the project. These Core Facilities are supported by UVA Cancer\r\nCenter grant #P30-CA044579. We are grateful to Dr. Jonathan A. Epstein for providing the\r\nNf1GRD/+ mouse strain (https://pubmed.ncbi.nlm.nih.gov/26460546/). This work was partly\r\nsupported by the National Institute of Neurological Diseases and Stroke R21 NS125479-01A1\r\n(H.Z.), American Cancer Society Institutional Research Grant to the University of Virginia\r\n(Y.J.), the National Natural Science Foundation of China #82072787 (M.Y.), the National\r\nCancer Institute U54 CA238114 (F.W.), U01 CA284193 (K.M.N.), and U54 CA274499 (K.A.J.,\r\nM.F-S.), the National institute of General Medical Sciences R35 GM133404 (M.F-S.), the Dr.\r\nMiriam and Sheldon G. Adelson Medical Research Foundation (H.I.K., S.A.G.), the National\r\nCenter for Advancing Translational Sciences KL2TR001882 (K.S.P.), Tower Cancer Career Development Grant (K.S.P.), McKnight Neurobiology of Brain Disorders Grant (K.S.P.). The\r\ncontent is solely the responsibility of the authors and does not necessarily represent the official\r\nviews of the National Institutes of Health. Illustrations in this manuscript were created with\r\nBioRender (BioRender.com).","publication":"bioRxiv","doi":"10.64898/2026.01.15.699808","OA_type":"green","publication_status":"published","date_created":"2026-02-10T12:55:55Z","date_published":"2026-01-16T00:00:00Z","oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"https://doi.org/10.64898/2026.01.15.699808"}],"title":"Critical role of cell competition in gliomagenesis","article_processing_charge":"No","day":"16","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","_id":"21212","date_updated":"2026-02-16T10:12:42Z","year":"2026","oa":1,"tmp":{"short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"OA_place":"repository","month":"01","author":[{"first_name":"Ying","last_name":"Jiang","full_name":"Jiang, Ying"},{"last_name":"Ahn","first_name":"Ryuhjin","full_name":"Ahn, Ryuhjin"},{"full_name":"Huang, Arthur","last_name":"Huang","first_name":"Arthur"},{"last_name":"Gonzalez","first_name":"Phillippe P.","full_name":"Gonzalez, Phillippe P."},{"full_name":"Kim, Jungeun","last_name":"Kim","first_name":"Jungeun"},{"full_name":"Zhang, Guoxin","first_name":"Guoxin","last_name":"Zhang"},{"full_name":"Liu, Zihao","last_name":"Liu","first_name":"Zihao"},{"full_name":"He, Zhenqiang","first_name":"Zhenqiang","last_name":"He"},{"full_name":"Dudley, Lindsey","first_name":"Lindsey","last_name":"Dudley"},{"full_name":"Patel, Kunal S.","first_name":"Kunal S.","last_name":"Patel"},{"full_name":"Dzhivhuho, Godfrey A.","last_name":"Dzhivhuho","first_name":"Godfrey A."},{"first_name":"Sam","last_name":"Crowl","full_name":"Crowl, Sam"},{"last_name":"Przanowski","first_name":"Piotr","full_name":"Przanowski, Piotr"},{"first_name":"Luisa Quesada","last_name":"Camacho","full_name":"Camacho, Luisa Quesada"},{"full_name":"Hao, Sijie","first_name":"Sijie","last_name":"Hao"},{"full_name":"Zeng, Jianhao","last_name":"Zeng","first_name":"Jianhao"},{"orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Mohammad","last_name":"Fallahi-Sichani","full_name":"Fallahi-Sichani, Mohammad"},{"first_name":"Kevin A.","last_name":"Janes","full_name":"Janes, Kevin A."},{"last_name":"Naegle","first_name":"Kristen M.","full_name":"Naegle, Kristen M."},{"full_name":"Hammarskjold, Marie-Louise","last_name":"Hammarskjold","first_name":"Marie-Louise"},{"full_name":"Goldman, Steven A.","first_name":"Steven A.","last_name":"Goldman"},{"full_name":"Kornblum, Harley I.","last_name":"Kornblum","first_name":"Harley I."},{"first_name":"Maojin","last_name":"Yao","full_name":"Yao, Maojin"},{"full_name":"White, Forest","first_name":"Forest","last_name":"White"},{"full_name":"Zong, Hui","last_name":"Zong","first_name":"Hui"}],"department":[{"_id":"SiHi"}]},{"page":"133-153","external_id":{"arxiv":["2410.01715"]},"abstract":[{"text":"Asteroseismology is the study of the interior physics and structure of stars using their pulsations. It is applicable to stars across the Hertzsprung–Russell (HR) diagram and a powerful technique not only to measure masses, radii, and ages but also directly constrain interior rotation, chemical mixing, and magnetism. This is because a star's self-excited pulsation modes are sensitive to its structure. Asteroseismology generally requires long-duration and high-precision time-series data. The method of forward asteroseismic modeling, which is the statistical comparison of observed pulsation mode frequencies to theoretically predicted pulsation frequencies calculated from a grid of models, provides precise constraints for calibrating various transport phenomena. In this introduction to asteroseismology, we provide an overview of its principles, and the typical data sets and methodologies used to constrain stellar interiors. Finally, we present key highlights of asteroseismic results from across the HR diagram, and conclude with ongoing challenges and future prospects for this ever-expanding field within stellar astrophysics.","lang":"eng"}],"OA_type":"green","arxiv":1,"title":"Asteroseismology","article_processing_charge":"No","publication_status":"published","oa_version":"Preprint","date_created":"2026-02-16T10:43:01Z","editor":[{"last_name":"Mandel","first_name":"Ilya","full_name":"Mandel, Ilya"}],"status":"public","scopus_import":"1","oa":1,"author":[{"last_name":"Bowman","first_name":"Dominic M.","full_name":"Bowman, Dominic M."},{"full_name":"Bugnet, Lisa Annabelle","orcid":"0000-0003-0142-4000","last_name":"Bugnet","first_name":"Lisa Annabelle","id":"d9edb345-f866-11ec-9b37-d119b5234501"}],"publisher":"Elsevier","department":[{"_id":"LiBu"}],"type":"book_chapter","citation":{"apa":"Bowman, D. M., &#38; Bugnet, L. A. (2026). Asteroseismology. In I. Mandel (Ed.), <i>Encyclopedia of Astrophysics</i> (Vol. 2, pp. 133–153). Elsevier. <a href=\"https://doi.org/10.1016/b978-0-443-21439-4.00036-5\">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>","ista":"Bowman DM, Bugnet LA. 2026.Asteroseismology. In: Encyclopedia of Astrophysics. vol. 2, 133–153.","ieee":"D. M. Bowman and L. A. Bugnet, “Asteroseismology,” in <i>Encyclopedia of Astrophysics</i>, vol. 2, I. Mandel, Ed. Elsevier, 2026, pp. 133–153.","ama":"Bowman DM, Bugnet LA. Asteroseismology. In: Mandel I, ed. <i>Encyclopedia of Astrophysics</i>. Vol 2. Elsevier; 2026:133-153. doi:<a href=\"https://doi.org/10.1016/b978-0-443-21439-4.00036-5\">10.1016/b978-0-443-21439-4.00036-5</a>","short":"D.M. Bowman, L.A. Bugnet, in:, I. Mandel (Ed.), Encyclopedia of Astrophysics, Elsevier, 2026, pp. 133–153.","mla":"Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” <i>Encyclopedia of Astrophysics</i>, edited by Ilya Mandel, vol. 2, Elsevier, 2026, pp. 133–53, doi:<a href=\"https://doi.org/10.1016/b978-0-443-21439-4.00036-5\">10.1016/b978-0-443-21439-4.00036-5</a>.","chicago":"Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” In <i>Encyclopedia of Astrophysics</i>, edited by Ilya Mandel, 2:133–53. Elsevier, 2026. <a href=\"https://doi.org/10.1016/b978-0-443-21439-4.00036-5\">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>."},"volume":2,"publication":"Encyclopedia of Astrophysics","intvolume":"         2","quality_controlled":"1","language":[{"iso":"eng"}],"doi":"10.1016/b978-0-443-21439-4.00036-5","day":"01","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2410.01715","open_access":"1"}],"date_published":"2026-01-01T00:00:00Z","date_updated":"2026-02-17T11:05:20Z","_id":"21230","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"repository","year":"2026","month":"01","publication_identifier":{"isbn":["9780443214400"]}},{"OA_type":"gold","article_processing_charge":"Yes (via OA deal)","title":"Simulation-based inference of cell migration dynamics in complex spatial environments","publication_status":"published","oa_version":"Published Version","date_created":"2026-02-16T10:44:31Z","external_id":{"pmid":["41611727"]},"abstract":[{"lang":"eng","text":"To assess cell migration in complex spatial environments, microfabricated chips, such as mazes and pillar forests, are routinely used to impose spatial and mechanical constraints, and cell trajectories are followed within these structures by advanced imaging techniques. In systems mechanobiology, computational models serve as essential tools to uncover how physical geometry influences intracellular dynamics; however, decoding such complex behaviors requires advanced inference techniques. Here, we integrated experimental observations of dendritic cell migration in a geometrically constrained microenvironment into a Cellular Potts model. We demonstrated that these spatial constraints modulate the motility dynamics, including speed and directional changes. We show that classical summary statistics, such as mean squared displacement and turning angle distributions, can resolve key mechanistic features but fail to extract richer spatiotemporal patterns, limiting accurate parameter inference. To solve this, we applied neural posterior estimation with in-the-loop learning of summary features. This learned summary representation of the data enables robust and flexible parameter inference, providing a data-driven framework for model calibration and advancing quantitative analysis of cell migration in structured microenvironments."}],"pmid":1,"file":[{"date_updated":"2026-02-23T10:09:03Z","file_id":"21346","file_size":10217687,"relation":"main_file","file_name":"2026_npjSysBioApp_Arruda.pdf","content_type":"application/pdf","creator":"dernst","access_level":"open_access","date_created":"2026-02-23T10:09:03Z","success":1,"checksum":"99b2e6bbaaedf45f22e07751948669f5"}],"article_type":"original","file_date_updated":"2026-02-23T10:09:03Z","author":[{"full_name":"Arruda, Jonas","last_name":"Arruda","first_name":"Jonas"},{"full_name":"Alamoudi, Emad","first_name":"Emad","last_name":"Alamoudi"},{"first_name":"Robert","last_name":"Mueller","full_name":"Mueller, Robert"},{"full_name":"Vaisband, Marc","first_name":"Marc","last_name":"Vaisband"},{"full_name":"Molkenbur, Ronja","first_name":"Ronja","last_name":"Molkenbur"},{"orcid":"0000-0001-5145-4609","full_name":"Merrin, Jack","first_name":"Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","last_name":"Merrin"},{"last_name":"Kiermaier","first_name":"Eva","full_name":"Kiermaier, Eva"},{"full_name":"Hasenauer, Jan","last_name":"Hasenauer","first_name":"Jan"}],"publisher":"Springer Nature","department":[{"_id":"NanoFab"}],"has_accepted_license":"1","status":"public","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa":1,"scopus_import":"1","DOAJ_listed":"1","doi":"10.1038/s41540-026-00648-9","day":"05","date_published":"2026-02-05T00:00:00Z","article_number":"20","type":"journal_article","citation":{"ieee":"J. Arruda <i>et al.</i>, “Simulation-based inference of cell migration dynamics in complex spatial environments,” <i>npj Systems Biology and Applications</i>, vol. 12. Springer Nature, 2026.","ama":"Arruda J, Alamoudi E, Mueller R, et al. Simulation-based inference of cell migration dynamics in complex spatial environments. <i>npj Systems Biology and Applications</i>. 2026;12. doi:<a href=\"https://doi.org/10.1038/s41540-026-00648-9\">10.1038/s41540-026-00648-9</a>","short":"J. Arruda, E. Alamoudi, R. Mueller, M. Vaisband, R. Molkenbur, J. Merrin, E. Kiermaier, J. Hasenauer, Npj Systems Biology and Applications 12 (2026).","chicago":"Arruda, Jonas, Emad Alamoudi, Robert Mueller, Marc Vaisband, Ronja Molkenbur, Jack Merrin, Eva Kiermaier, and Jan Hasenauer. “Simulation-Based Inference of Cell Migration Dynamics in Complex Spatial Environments.” <i>Npj Systems Biology and Applications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41540-026-00648-9\">https://doi.org/10.1038/s41540-026-00648-9</a>.","mla":"Arruda, Jonas, et al. “Simulation-Based Inference of Cell Migration Dynamics in Complex Spatial Environments.” <i>Npj Systems Biology and Applications</i>, vol. 12, 20, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41540-026-00648-9\">10.1038/s41540-026-00648-9</a>.","apa":"Arruda, J., Alamoudi, E., Mueller, R., Vaisband, M., Molkenbur, R., Merrin, J., … Hasenauer, J. (2026). Simulation-based inference of cell migration dynamics in complex spatial environments. <i>Npj Systems Biology and Applications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41540-026-00648-9\">https://doi.org/10.1038/s41540-026-00648-9</a>","ista":"Arruda J, Alamoudi E, Mueller R, Vaisband M, Molkenbur R, Merrin J, Kiermaier E, Hasenauer J. 2026. Simulation-based inference of cell migration dynamics in complex spatial environments. npj Systems Biology and Applications. 12, 20."},"ddc":["570"],"volume":12,"intvolume":"        12","publication":"npj Systems Biology and Applications","acknowledgement":"This work was supported by the German Federal Ministry of Education and Research (BMBF) (EMUNE/031L0293C), the European Union via the ERC grant INTEGRATE, grant agreement number 101126146, and under Germany’s Excellence Strategy by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (EXC 2047—390685813, EXC 2151—390873048, FOR5775 — 533863915, and 524747443), the University of Bonn via the Schlegel Professorship of J.H., and the returning experts fellowship of the Ministry of Innovation, Science, and Research of North-Rhine-Westphalia (AZ: 421-8.03.03.02-137069). J.M. is a member of the Nanofabrication Facility and is supported by the Institute of Science and Technology Austria. E.K. acknowledges the TRA Life and Health (University of Bonn) as part of the Excellence Strategy of the federal and state governments. The authors thank Laeschkir Würthner for his insightful comments on the implementation of the authors’ model. The views and opinions expressed are those of the authors only and do not necessarily reflect those of the funding agencies. Parts of Fig. 1 were created using BioRender. Open Access funding enabled and organized by Projekt DEAL.","language":[{"iso":"eng"}],"quality_controlled":"1","month":"02","publication_identifier":{"eissn":["2056-7189"]},"date_updated":"2026-02-23T10:10:10Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21231","PlanS_conform":"1","OA_place":"publisher","year":"2026"},{"abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title>\r\n                  <jats:p>In this paper, we consider a simple class of stratified spaces – 2-complexes. We present an algorithm that learns the abstract structure of an embedded 2-complex from a point cloud sampled from it. We use tools and inspiration from computational geometry, algebraic topology, and topological data analysis and prove the correctness of the identified abstract structure under assumptions on the embedding.</jats:p>"}],"external_id":{"arxiv":["2305.02724"]},"file":[{"creator":"dernst","content_type":"application/pdf","file_name":"2026_LaMatematica_Bleile.pdf","relation":"main_file","checksum":"6cae2efb47b025af22a8539c606a4e09","date_created":"2026-02-23T10:18:52Z","success":1,"access_level":"open_access","date_updated":"2026-02-23T10:18:52Z","file_size":15051582,"file_id":"21347"}],"article_type":"original","file_date_updated":"2026-02-23T10:18:52Z","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","title":"Towards stratified space learning: 2-complexes","arxiv":1,"publication_status":"published","date_created":"2026-02-16T10:44:44Z","oa_version":"Published Version","has_accepted_license":"1","status":"public","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa":1,"scopus_import":"1","corr_author":"1","author":[{"full_name":"Bleile, Yossi","orcid":"0000-0002-4861-9174","last_name":"Bleile","first_name":"Yossi","id":"920a7385-7995-11ef-9bfd-8c434cd8f3c2"}],"department":[{"_id":"HeEd"}],"publisher":"Springer Nature","type":"journal_article","citation":{"mla":"Bokor Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.” <i>La Matematica</i>, vol. 5, 17, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1007/s44007-025-00183-9\">10.1007/s44007-025-00183-9</a>.","chicago":"Bokor Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.” <i>La Matematica</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/s44007-025-00183-9\">https://doi.org/10.1007/s44007-025-00183-9</a>.","short":"Y. Bokor Bleile, La Matematica 5 (2026).","ama":"Bokor Bleile Y. Towards stratified space learning: 2-complexes. <i>La Matematica</i>. 2026;5. doi:<a href=\"https://doi.org/10.1007/s44007-025-00183-9\">10.1007/s44007-025-00183-9</a>","ieee":"Y. Bokor Bleile, “Towards stratified space learning: 2-complexes,” <i>La Matematica</i>, vol. 5. Springer Nature, 2026.","ista":"Bokor Bleile Y. 2026. Towards stratified space learning: 2-complexes. La Matematica. 5, 17.","apa":"Bokor Bleile, Y. (2026). Towards stratified space learning: 2-complexes. <i>La Matematica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s44007-025-00183-9\">https://doi.org/10.1007/s44007-025-00183-9</a>"},"ddc":["510"],"volume":5,"intvolume":"         5","acknowledgement":"The author would like to thank Kate Turner, Chris Williams, Jonathan Spreer, Stephan Tillmann, Vanessa Robins, Vigleik Angeltveit, Martin Helmer, and James Morgan for very helpful discussions; and thanks Sara Kališnik Hintz and Paul Bendich for comments on an earlier version. Additonally, the author would like to thank both reviewers for their very insightful and helpful comments, without which the paper would be infinitely less coherent than it currently is. Open access funding provided by Institute of Science and Technology (IST Austria). The work in this paper was supported by an Australian Federal Government Grant, 2019-2022, Stratified Space Learning.","publication":"La Matematica","language":[{"iso":"eng"}],"quality_controlled":"1","doi":"10.1007/s44007-025-00183-9","day":"08","article_number":"17","date_published":"2026-02-08T00:00:00Z","date_updated":"2026-06-11T11:51:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21232","PlanS_conform":"1","OA_place":"publisher","year":"2026","month":"02","publication_identifier":{"issn":["2730-9657"]}},{"quality_controlled":"1","language":[{"iso":"eng"}],"acknowledgement":"We would like to thank the Summer School Systems Genetics of Neural Ageing for bringing us together and spurring our international collaboration. We would also like to acknowledge the funding for the Summer School 2022 from the e:Med Systems Medicine Program of the BMBF (Bundesministerium für Bildung und Forschung; German Ministry of Education and Research) to R.W.O. In addition, we would like to thank the FLI imaging core facility for their assistance. A.G.-P. is supported by Fundación Séneca, Región de Murcia, Spain (21259/FPI/19). D.E.M.d.B. is financed by a Rubicon scholarship (452021116) from the Dutch Research Council (NWO). This work was also supported by NIH NIA R01AG070913-01 (R.W.W.), R01AG075813-01 (D.G.A.), and R01AG075818 (C.K.). We acknowledge the help of Larry Mobraaten (Jackson Laboratory, Bar Harbor, MN) with the BXD strains and U. Obermüller for the help with the histology. For the purpose of open access, the authors have applied a CC BY public copyright license to all author-accepted manuscripts arising from this submission.","publication":"Cell Systems","intvolume":"        17","volume":17,"ddc":["570"],"citation":{"ieee":"A. Gómez-Pascual <i>et al.</i>, “The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus,” <i>Cell Systems</i>, vol. 17, no. 2. Elsevier, 2026.","short":"A. Gómez-Pascual, D.M. Glikman, H.X. Ng, J.E. Tomkins, L. Lu, Y. Xu, D.G. Ashbrook, C. Kaczorowski, G. Kempermann, J. Killmar, K. Mozhui, O. Ohlenschläger, R. Aebersold, D.K. Ingram, E.G. Williams, M. Jucker, R.W. Overall, R.W. Williams, D.E.M. de Bakker, Cell Systems 17 (2026).","ama":"Gómez-Pascual A, Glikman DM, Ng HX, et al. The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>. 2026;17(2). doi:<a href=\"https://doi.org/10.1016/j.cels.2025.101488\">10.1016/j.cels.2025.101488</a>","mla":"Gómez-Pascual, Alicia, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>, vol. 17, no. 2, 101488, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.cels.2025.101488\">10.1016/j.cels.2025.101488</a>.","chicago":"Gómez-Pascual, Alicia, Dow M Glikman, Hui Xin Ng, James E. Tomkins, Lu Lu, Ying Xu, David G. Ashbrook, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.cels.2025.101488\">https://doi.org/10.1016/j.cels.2025.101488</a>.","apa":"Gómez-Pascual, A., Glikman, D. M., Ng, H. X., Tomkins, J. E., Lu, L., Xu, Y., … de Bakker, D. E. M. (2026). The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cels.2025.101488\">https://doi.org/10.1016/j.cels.2025.101488</a>","ista":"Gómez-Pascual A, Glikman DM, Ng HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski C, Kempermann G, Killmar J, Mozhui K, Ohlenschläger O, Aebersold R, Ingram DK, Williams EG, Jucker M, Overall RW, Williams RW, de Bakker DEM. 2026. The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. Cell Systems. 17(2), 101488."},"type":"journal_article","article_number":"101488","date_published":"2026-02-18T00:00:00Z","day":"18","doi":"10.1016/j.cels.2025.101488","year":"2026","OA_place":"publisher","PlanS_conform":"1","_id":"21234","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-02-23T10:35:01Z","publication_identifier":{"issn":["2405-4712"]},"month":"02","file_date_updated":"2026-02-23T10:32:12Z","article_type":"original","file":[{"creator":"dernst","content_type":"application/pdf","file_name":"2026_CellSystems_GomezPascual.pdf","relation":"main_file","checksum":"920e8edfd3b8b42f5bb6f86d4c66c54d","date_created":"2026-02-23T10:32:12Z","success":1,"access_level":"open_access","date_updated":"2026-02-23T10:32:12Z","file_size":10606778,"file_id":"21349"}],"pmid":1,"abstract":[{"lang":"eng","text":"In aged humans and mice, hypobranched glycogen aggregates, known as polyglucosan bodies (PGBs), accumulate in hippocampal astrocytes. While PGBs are linked to cognitive decline in neurological diseases, they remain largely unstudied in the context of typical aging. We show that PGBs arise in autophagy-dysregulated astrocytes in the aged hippocampus, with substantial variation among 32 inbred BXD mouse strains. Genetic mapping through quantitative trait locus analysis identified a major locus (Pgb1) that modulates hippocampal PGB burden. Extensive transcriptomic and proteomic datasets were produced for the aged hippocampus of the BXD family to investigate the mechanism by which the Pgb1 locus modulates PGB burden. We identified that Pgb1 contains allelic Smarcal1 and Usp37 variants and influences PGB burden through trans-regulation of mRNA and protein expression levels, including abundance of glycogen-mobilizing factor PYGB. Furthermore, comprehensive phenome-wide association scans, transcriptomic analyses, and direct behavioral testing demonstrated that cognition remains intact despite age-related PGB burden. A record of this paper’s transparent peer review process is included in the supplemental information."}],"external_id":{"pmid":["41633365"]},"publication_status":"published","date_created":"2026-02-16T10:45:10Z","oa_version":"Published Version","title":"The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus","article_processing_charge":"No","issue":"2","OA_type":"hybrid","scopus_import":"1","oa":1,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","has_accepted_license":"1","department":[{"_id":"GradSch"}],"publisher":"Elsevier","author":[{"first_name":"Alicia","last_name":"Gómez-Pascual","full_name":"Gómez-Pascual, Alicia"},{"id":"ab8acda1-91c1-11f0-aad8-f75d3d6424d8","first_name":"Dow M","last_name":"Glikman","full_name":"Glikman, Dow M"},{"full_name":"Ng, Hui Xin","last_name":"Ng","first_name":"Hui Xin"},{"first_name":"James E.","last_name":"Tomkins","full_name":"Tomkins, James E."},{"last_name":"Lu","first_name":"Lu","full_name":"Lu, Lu"},{"full_name":"Xu, Ying","first_name":"Ying","last_name":"Xu"},{"last_name":"Ashbrook","first_name":"David G.","full_name":"Ashbrook, David G."},{"last_name":"Kaczorowski","first_name":"Catherine","full_name":"Kaczorowski, Catherine"},{"last_name":"Kempermann","first_name":"Gerd","full_name":"Kempermann, Gerd"},{"last_name":"Killmar","first_name":"John","full_name":"Killmar, John"},{"full_name":"Mozhui, Khyobeni","first_name":"Khyobeni","last_name":"Mozhui"},{"last_name":"Ohlenschläger","first_name":"Oliver","full_name":"Ohlenschläger, Oliver"},{"last_name":"Aebersold","first_name":"Rudolf","full_name":"Aebersold, Rudolf"},{"full_name":"Ingram, Donald K.","first_name":"Donald K.","last_name":"Ingram"},{"first_name":"Evan G.","last_name":"Williams","full_name":"Williams, Evan G."},{"full_name":"Jucker, Mathias","first_name":"Mathias","last_name":"Jucker"},{"first_name":"Rupert W.","last_name":"Overall","full_name":"Overall, Rupert W."},{"full_name":"Williams, Robert W.","first_name":"Robert W.","last_name":"Williams"},{"full_name":"de Bakker, Dennis E.M.","first_name":"Dennis E.M.","last_name":"de Bakker"}]},{"title":"Hydrodynamic permeability of fluctuating porous membranes","article_processing_charge":"No","arxiv":1,"date_created":"2026-02-17T08:10:09Z","publication_status":"published","oa_version":"Preprint","OA_type":"green","issue":"1","article_type":"original","external_id":{"arxiv":["2512.11368"]},"abstract":[{"lang":"eng","text":"In this paper we examine how porosity fluctuations affect the hydrodynamic permeability of a porous matrix or membrane. We introduce a fluctuating Darcy model, which couples the Navier-Stokes equation to the space- and time-dependent porosity fluctuations via a Darcy friction term. Using a perturbative approach, a Dyson equation for hydrodynamic fluctuations is derived and solved to express the permeability in terms of the matrix fluctuation spectrum. Surprisingly, the model reveals strong modifications of the fluid permeability in fluctuating matrices compared to static ones. Applications to various matrix excitation models, the breathing matrix, phonons, and active forcing, highlight the significant influence of matrix fluctuations on fluid transport, offering insights for optimizing membrane design for separation applications."}],"publisher":"American Physical Society","department":[{"_id":"MiLe"}],"corr_author":"1","author":[{"full_name":"Dombret, Albert","last_name":"Dombret","first_name":"Albert"},{"first_name":"Adrien","last_name":"Sutter","full_name":"Sutter, Adrien"},{"orcid":"0000-0001-5524-596X","full_name":"Coquinot, Baptiste","last_name":"Coquinot","first_name":"Baptiste","id":"f8417bd4-f599-11ee-a482-b927e3ed1e8e"},{"last_name":"Kavokine","first_name":"Nikita","full_name":"Kavokine, Nikita"},{"last_name":"Coasne","first_name":"Benoit","full_name":"Coasne, Benoit"},{"full_name":"Bocquet, Lydéric","last_name":"Bocquet","first_name":"Lydéric"}],"oa":1,"status":"public","day":"21","article_number":"014201","date_published":"2026-01-21T00:00:00Z","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2512.11368","open_access":"1"}],"doi":"10.1103/m8h6-1wfk","intvolume":"        11","acknowledgement":"The authors acknowledge support from ERC project n-AQUA, Grant Agreement No. 101071937.\r\nB.C. and A.S. acknowledge support from the CFM Foundation. B.C. acknowledges support from\r\nthe NOMIS Foundation.","publication":"Physical Review Fluids","language":[{"iso":"eng"}],"quality_controlled":"1","citation":{"chicago":"Dombret, Albert, Adrien Sutter, Baptiste Coquinot, Nikita Kavokine, Benoit Coasne, and Lydéric Bocquet. “Hydrodynamic Permeability of Fluctuating Porous Membranes.” <i>Physical Review Fluids</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/m8h6-1wfk\">https://doi.org/10.1103/m8h6-1wfk</a>.","mla":"Dombret, Albert, et al. “Hydrodynamic Permeability of Fluctuating Porous Membranes.” <i>Physical Review Fluids</i>, vol. 11, no. 1, 014201, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/m8h6-1wfk\">10.1103/m8h6-1wfk</a>.","short":"A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, L. Bocquet, Physical Review Fluids 11 (2026).","ama":"Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. Hydrodynamic permeability of fluctuating porous membranes. <i>Physical Review Fluids</i>. 2026;11(1). doi:<a href=\"https://doi.org/10.1103/m8h6-1wfk\">10.1103/m8h6-1wfk</a>","ieee":"A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, and L. Bocquet, “Hydrodynamic permeability of fluctuating porous membranes,” <i>Physical Review Fluids</i>, vol. 11, no. 1. American Physical Society, 2026.","ista":"Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. 2026. Hydrodynamic permeability of fluctuating porous membranes. Physical Review Fluids. 11(1), 014201.","apa":"Dombret, A., Sutter, A., Coquinot, B., Kavokine, N., Coasne, B., &#38; Bocquet, L. (2026). Hydrodynamic permeability of fluctuating porous membranes. <i>Physical Review Fluids</i>. American Physical Society. <a href=\"https://doi.org/10.1103/m8h6-1wfk\">https://doi.org/10.1103/m8h6-1wfk</a>"},"type":"journal_article","volume":11,"publication_identifier":{"eissn":["2469-990X"]},"month":"01","OA_place":"repository","year":"2026","date_updated":"2026-02-23T12:01:57Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21273"},{"ddc":["520"],"volume":706,"type":"journal_article","citation":{"ista":"Cristea A-A, Caiazzo I, Cunningham T, Raymond JC, Vennes S, Kawka A, Desai AA, Miller DR, Hermes JJ, Fuller J, Heyl J, van Roestel J, Burdge KB, Rodriguez AC, Pelisoli I, Gänsicke BT, Szkody P, Kenyon SJ, Vanderbosch Z, Drake A, Ferrario L, Wickramasinghe D, Karambelkar VR, Justham S, Pakmor R, El-Badry K, Prince T, Kulkarni SR, Graham MJ, Masci FJ, Groom SL, Purdum J, Dekany R, Bellm EC. 2026. A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant. Astronomy &#38; Astrophysics. 706, A188.","apa":"Cristea, A.-A., Caiazzo, I., Cunningham, T., Raymond, J. C., Vennes, S., Kawka, A., … Bellm, E. C. (2026). A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/202556432\">https://doi.org/10.1051/0004-6361/202556432</a>","chicago":"Cristea, Andrei-Alexandru, Ilaria Caiazzo, Tim Cunningham, John C. Raymond, Stephane Vennes, Adela Kawka, Aayush A Desai, et al. “A Half Ring of Ionized Circumstellar Material Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2026. <a href=\"https://doi.org/10.1051/0004-6361/202556432\">https://doi.org/10.1051/0004-6361/202556432</a>.","mla":"Cristea, Andrei-Alexandru, et al. “A Half Ring of Ionized Circumstellar Material Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” <i>Astronomy &#38; Astrophysics</i>, vol. 706, A188, EDP Sciences, 2026, doi:<a href=\"https://doi.org/10.1051/0004-6361/202556432\">10.1051/0004-6361/202556432</a>.","short":"A.-A. Cristea, I. Caiazzo, T. Cunningham, J.C. Raymond, S. Vennes, A. Kawka, A.A. Desai, D.R. Miller, J.J. Hermes, J. Fuller, J. Heyl, J. van Roestel, K.B. Burdge, A.C. Rodriguez, I. Pelisoli, B.T. Gänsicke, P. Szkody, S.J. Kenyon, Z. Vanderbosch, A. Drake, L. Ferrario, D. Wickramasinghe, V.R. Karambelkar, S. Justham, R. Pakmor, K. El-Badry, T. Prince, S.R. Kulkarni, M.J. Graham, F.J. Masci, S.L. Groom, J. Purdum, R. Dekany, E.C. Bellm, Astronomy &#38; Astrophysics 706 (2026).","ama":"Cristea A-A, Caiazzo I, Cunningham T, et al. A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant. <i>Astronomy &#38; Astrophysics</i>. 2026;706. doi:<a href=\"https://doi.org/10.1051/0004-6361/202556432\">10.1051/0004-6361/202556432</a>","ieee":"A.-A. Cristea <i>et al.</i>, “A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant,” <i>Astronomy &#38; Astrophysics</i>, vol. 706. EDP Sciences, 2026."},"language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"       706","publication":"Astronomy & Astrophysics","acknowledgement":"We thank Lynne Hillenbrand and Soumyadeep Bhattacharjee for helpful discussions, and Kishalay De for his help with the WIRC\r\nreduction pipeline. IC was supported by NASA through grants from the Space\r\nTelescope Science Institute, under NASA contracts NASA.22K1813, NAS5-\r\n26555 and NAS5-03127. TC was supported by NASA through the NASA Hubble\r\nFellowship grant HST-HF2-51527.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research\r\nin Astronomy, Inc., for NASA, under contract NAS5-26555. This project has\r\nreceived funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 101020057). This work was based on observations obtained with the\r\nSamuel Oschin Telescope 48-inch and the 60-inch Telescope at the Palomar\r\nObservatory as part of the Zwicky Transient Facility project. ZTF is supported\r\nby the National Science Foundation under Grants No. AST-1440341, AST2034437, and currently Award #2407588. ZTF receives additional funding from\r\nthe ZTF partnership. Current members include Caltech, USA; Caltech/IPAC,\r\nUSA; University of Maryland, USA; University of California, Berkeley, USA;\r\nUniversity of Wisconsin at Milwaukee, USA; Cornell University, USA; Drexel\r\nUniversity, USA; University of North Carolina at Chapel Hill, USA; Institute\r\nof Science and Technology, Austria; National Central University, Taiwan, and\r\nOKC, University of Stockholm, Sweden. Operations are conducted by Caltech’s\r\nOptical Observatory (COO), Caltech/IPAC, and the University of Washington at\r\nSeattle, USA. This work has made use of data from the European Space Agency\r\n(ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by\r\nthe Gaia Data Processing and Analysis Consortium (DPAC, https://www.\r\ncosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. The Pan-STARRS1 Surveys (PS1)\r\nand the PS1 public science archive have been made possible through contributions by the Institute for Astronomy, the University of Hawaii, the PanSTARRS Project Office, the Max-Planck Society and its participating institutes, the Max Planck Institute for Astronomy, Heidelberg and the Max Planck\r\nInstitute for Extraterrestrial Physics, Garching, The Johns Hopkins University,\r\nDurham University, the University of Edinburgh, the Queen’s University Belfast,\r\nthe Harvard-Smithsonian Center for Astrophysics, the Las Cumbres Observatory Global Telescope Network Incorporated, the National Central University of Taiwan, the Space Telescope Science Institute, the National Aeronautics and Space Administration under Grant No. NNX08AR22G issued through\r\nthe Planetary Science Division of the NASA Science Mission Directorate, the\r\nNational Science Foundation Grant No. AST–1238877, the University of Maryland, Eotvos Lorand University (ELTE), the Los Alamos National Laboratory,\r\nand the Gordon and Betty Moore Foundation. This work made use of Astropy\r\n(http://www.astropy.org): a community-developed core Python package\r\nand an ecosystem of tools and resources for astronomy (Astropy Collaboration\r\n2013, 2018, 2022).","doi":"10.1051/0004-6361/202556432","DOAJ_listed":"1","article_number":"A188","date_published":"2026-02-10T00:00:00Z","day":"10","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"21274","date_updated":"2026-04-28T12:01:21Z","year":"2026","PlanS_conform":"1","OA_place":"publisher","month":"02","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"file":[{"checksum":"229b688e6e78cab5bb8e2bac366d1575","success":1,"date_created":"2026-02-23T12:04:37Z","access_level":"open_access","creator":"dernst","relation":"main_file","file_name":"2026_AstronomyAstrophysics_Cristea.pdf","content_type":"application/pdf","file_size":5352853,"file_id":"21350","date_updated":"2026-02-23T12:04:37Z"}],"abstract":[{"text":"Many white dwarfs are observed in compact double white dwarf binaries, and through the emission of gravitational waves, a large fraction are destined to merge. The merger remnants that do not explode in a Type Ia supernova are expected to initially be rapidly rotating and highly magnetized. In this work, we present our discovery of the variable white dwarf ZTF J200832.79+444939.67, hereafter ZTF J2008+4449, as a likely merger remnant showing signs of circumstellar material without a stellar or substellar companion. The nature of ZTF J2008+4449 as a merger remnant is supported by its physical properties: it is hot (35 500 ± 300 K) and massive (1.12 ± 0.03 M\r\n                    <jats:sub>⊙</jats:sub>\r\n                    ), rapidly rotating with a period of ≈6.6 minutes, and likely possesses exceptionally strong magnetic fields (∼400−600 MG) at its surface. Remarkably, we detect a significant period derivative of (1.80 ± 0.09)×10\r\n                    <jats:sup>−12</jats:sup>\r\n                    s/s, indicating that the white dwarf is spinning down, and a soft X-ray emission that is inconsistent with photospheric emission. As the presence of a mass-transferring stellar or brown dwarf companion is excluded by infrared photometry, the detected spin-down and X-ray emission could be tell-tale signs of a magnetically driven wind or of interaction with circumstellar material, possibly originating from the fallback of gravitationally bound merger ejecta or from the tidal disruption of a planetary object. We also detect Balmer emission, which requires the presence of ionized hydrogen in the vicinity of the white dwarf, showing Doppler shifts as high as ≈2000 km s\r\n                    <jats:sup>−1</jats:sup>\r\n                    . The unusual variability of the Balmer emission on the spin period of the white dwarf is consistent with the trapping of a half ring of ionized gas in the magnetosphere of the white dwarf.\r\n                  </jats:p>","lang":"eng"}],"article_type":"original","file_date_updated":"2026-02-23T12:04:37Z","OA_type":"gold","related_material":{"link":[{"url":"https://ista.ac.at/en/news/twos-company-new-class-of-star-remnants/","relation":"press_release","description":"News on ISTA website"}]},"oa_version":"Published Version","publication_status":"published","date_created":"2026-02-17T08:12:05Z","title":"A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant","article_processing_charge":"Yes","has_accepted_license":"1","status":"public","oa":1,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"corr_author":"1","author":[{"full_name":"Cristea, Andrei-Alexandru","first_name":"Andrei-Alexandru","id":"4d500bea-31f8-11ee-a48d-d4904fb363c7","last_name":"Cristea"},{"id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","first_name":"Ilaria","last_name":"Caiazzo","orcid":"0000-0002-4770-5388","full_name":"Caiazzo, Ilaria"},{"full_name":"Cunningham, Tim","first_name":"Tim","last_name":"Cunningham"},{"first_name":"John C.","last_name":"Raymond","full_name":"Raymond, John C."},{"full_name":"Vennes, Stephane","first_name":"Stephane","last_name":"Vennes"},{"last_name":"Kawka","first_name":"Adela","full_name":"Kawka, Adela"},{"first_name":"Aayush A","id":"502cfd30-32c1-11ee-a9a4-d8dad5c6739e","last_name":"Desai","full_name":"Desai, Aayush A"},{"first_name":"David R.","last_name":"Miller","full_name":"Miller, David R."},{"full_name":"Hermes, J. J.","last_name":"Hermes","first_name":"J. J."},{"first_name":"Jim","last_name":"Fuller","full_name":"Fuller, Jim"},{"full_name":"Heyl, Jeremy","first_name":"Jeremy","last_name":"Heyl"},{"full_name":"van Roestel, Jan","first_name":"Jan","last_name":"van Roestel"},{"first_name":"Kevin B.","last_name":"Burdge","full_name":"Burdge, Kevin B."},{"full_name":"Rodriguez, Antonio C.","first_name":"Antonio C.","last_name":"Rodriguez"},{"full_name":"Pelisoli, Ingrid","last_name":"Pelisoli","first_name":"Ingrid"},{"last_name":"Gänsicke","first_name":"Boris T.","full_name":"Gänsicke, Boris T."},{"full_name":"Szkody, Paula","first_name":"Paula","last_name":"Szkody"},{"full_name":"Kenyon, Scott J.","first_name":"Scott J.","last_name":"Kenyon"},{"first_name":"Zach","last_name":"Vanderbosch","full_name":"Vanderbosch, Zach"},{"full_name":"Drake, Andrew","first_name":"Andrew","last_name":"Drake"},{"last_name":"Ferrario","first_name":"Lilia","full_name":"Ferrario, Lilia"},{"first_name":"Dayal","last_name":"Wickramasinghe","full_name":"Wickramasinghe, Dayal"},{"full_name":"Karambelkar, Viraj R.","last_name":"Karambelkar","first_name":"Viraj R."},{"last_name":"Justham","first_name":"Stephen","full_name":"Justham, Stephen"},{"full_name":"Pakmor, Ruediger","first_name":"Ruediger","last_name":"Pakmor"},{"first_name":"Kareem","last_name":"El-Badry","full_name":"El-Badry, Kareem"},{"full_name":"Prince, Thomas","first_name":"Thomas","last_name":"Prince"},{"first_name":"S. R.","last_name":"Kulkarni","full_name":"Kulkarni, S. R."},{"full_name":"Graham, Matthew J.","first_name":"Matthew J.","last_name":"Graham"},{"last_name":"Masci","first_name":"Frank J.","full_name":"Masci, Frank J."},{"first_name":"Steven L.","last_name":"Groom","full_name":"Groom, Steven L."},{"full_name":"Purdum, Josiah","first_name":"Josiah","last_name":"Purdum"},{"full_name":"Dekany, Richard","first_name":"Richard","last_name":"Dekany"},{"first_name":"Eric C.","last_name":"Bellm","full_name":"Bellm, Eric C."}],"publisher":"EDP Sciences","department":[{"_id":"IlCa"},{"_id":"GradSch"}]},{"date_published":"2026-02-09T00:00:00Z","article_number":"013018","day":"09","doi":"10.1103/89bj-79g5","DOAJ_listed":"1","quality_controlled":"1","language":[{"iso":"eng"}],"acknowledgement":"This project has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No. 950349 and the Marie Skłodowska-Curie Grant Agreement No. 101034413. The computations in this paper were run in part on the the FASRC Cannon cluster supported by the FAS Division of Science Research Computing Group at Harvard University and the cluster of the Max Planck Institute for the Physics of Complex Systems.","publication":"PRX Life","intvolume":"         4","volume":4,"ddc":["570"],"citation":{"ieee":"F. Olmeda, M. Gupta, O. Bektas, and S. Rulands, “Spatiotemporal patterns of active epigenetic turnover,” <i>PRX Life</i>, vol. 4. American Physical Society, 2026.","mla":"Olmeda, Fabrizio, et al. “Spatiotemporal Patterns of Active Epigenetic Turnover.” <i>PRX Life</i>, vol. 4, 013018, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/89bj-79g5\">10.1103/89bj-79g5</a>.","chicago":"Olmeda, Fabrizio, Misha Gupta, Onurcan Bektas, and Steffen Rulands. “Spatiotemporal Patterns of Active Epigenetic Turnover.” <i>PRX Life</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/89bj-79g5\">https://doi.org/10.1103/89bj-79g5</a>.","ama":"Olmeda F, Gupta M, Bektas O, Rulands S. Spatiotemporal patterns of active epigenetic turnover. <i>PRX Life</i>. 2026;4. doi:<a href=\"https://doi.org/10.1103/89bj-79g5\">10.1103/89bj-79g5</a>","short":"F. Olmeda, M. Gupta, O. Bektas, S. Rulands, PRX Life 4 (2026).","apa":"Olmeda, F., Gupta, M., Bektas, O., &#38; Rulands, S. (2026). Spatiotemporal patterns of active epigenetic turnover. <i>PRX Life</i>. American Physical Society. <a href=\"https://doi.org/10.1103/89bj-79g5\">https://doi.org/10.1103/89bj-79g5</a>","ista":"Olmeda F, Gupta M, Bektas O, Rulands S. 2026. Spatiotemporal patterns of active epigenetic turnover. PRX Life. 4, 013018."},"type":"journal_article","ec_funded":1,"publication_identifier":{"eissn":["2835-8279"]},"month":"02","year":"2026","OA_place":"publisher","PlanS_conform":"1","_id":"21275","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-02-24T06:54:32Z","publication_status":"published","date_created":"2026-02-17T08:17:53Z","oa_version":"Published Version","title":"Spatiotemporal patterns of active epigenetic turnover","article_processing_charge":"Yes","OA_type":"gold","file_date_updated":"2026-02-24T06:53:05Z","article_type":"original","file":[{"file_size":5857833,"file_id":"21351","date_updated":"2026-02-24T06:53:05Z","checksum":"df9776422862d1d02c66d98e2d620849","access_level":"open_access","date_created":"2026-02-24T06:53:05Z","success":1,"relation":"main_file","file_name":"2026_PRXLife_Olmeda.pdf","content_type":"application/pdf","creator":"dernst"}],"abstract":[{"lang":"eng","text":"DNA methylation is a primary layer of epigenetic modification that plays a pivotal role in the regulation of development, aging, and cancer. The concurrent activity of opposing enzymes that mediate DNA methylation and demethylation gives rise to a biochemical cycle and active turnover of DNA methylation. While the ensuing biochemical oscillations have been implicated in the regulation of cell differentiation, their functional role and spatiotemporal dynamics are unknown. In this work, we demonstrate that chromatin-mediated coupling between these local biochemical cycles can lead to the emergence of phase-locked domains, regions of locally synchronized turnover activity, whose coarsening is arrested by genomic heterogeneity. We introduce a minimal model based on stochastic oscillators with constrained long-range and nonreciprocal interactions, shaped by the local chromatin organization. Through a combination of analytical theory and stochastic simulations, we predict both the degree of synchronization and the typical size of emergent phase-locked domains. We qualitatively test these predictions using single-cell sequencing data. Our results show that DNA methylation turnover exhibits surprisingly rich spatiotemporal patterns that may be used by cells to control cell differentiation."}],"department":[{"_id":"EdHa"}],"publisher":"American Physical Society","corr_author":"1","author":[{"last_name":"Olmeda","id":"69dbf5fb-8a76-11ed-866b-fb486d8b5689","first_name":"Fabrizio","full_name":"Olmeda, Fabrizio"},{"full_name":"Gupta, Misha","last_name":"Gupta","first_name":"Misha"},{"full_name":"Bektas, Onurcan","first_name":"Onurcan","last_name":"Bektas"},{"full_name":"Rulands, Steffen","last_name":"Rulands","first_name":"Steffen"}],"project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program"}],"oa":1,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","has_accepted_license":"1"}]