[{"scopus_import":"1","publication_status":"published","has_accepted_license":"1","article_number":"e51787","oa_version":"Published Version","day":"08","ddc":["580"],"abstract":[{"lang":"eng","text":"Hormonal signalling in animals often involves direct transcription factor-hormone interactions that modulate gene expression. In contrast, plant hormone signalling is most commonly based on de-repression via the degradation of transcriptional repressors. Recently, we uncovered a non-canonical signalling mechanism for the plant hormone auxin whereby auxin directly affects the activity of the atypical auxin response factor (ARF), ETTIN towards target genes without the requirement for protein degradation. Here we show that ETTIN directly binds auxin, leading to dissociation from co-repressor proteins of the TOPLESS/TOPLESS-RELATED family followed by histone acetylation and induction of gene expression. This mechanism is reminiscent of animal hormone signalling as it affects the activity towards regulation of target genes and provides the first example of a DNA-bound hormone receptor in plants. Whilst auxin affects canonical ARFs indirectly by facilitating degradation of Aux/IAA repressors, direct ETTIN-auxin interactions allow switching between repressive and de-repressive chromatin states in an instantly-reversible manner."}],"publication":"eLife","external_id":{"pmid":["32267233"],"isi":["000527752200001"]},"author":[{"last_name":"Kuhn","full_name":"Kuhn, André","first_name":"André"},{"last_name":"Ramans Harborough","first_name":"Sigurd","full_name":"Ramans Harborough, Sigurd"},{"first_name":"Heather M","full_name":"McLaughlin, Heather M","last_name":"McLaughlin"},{"first_name":"Bhavani","full_name":"Natarajan, Bhavani","last_name":"Natarajan"},{"orcid":"0000-0001-7241-2328","last_name":"Verstraeten","full_name":"Verstraeten, Inge","first_name":"Inge","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-8302-7596","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"},{"last_name":"Kepinski","full_name":"Kepinski, Stefan","first_name":"Stefan"},{"full_name":"Østergaard, Lars","first_name":"Lars","last_name":"Østergaard"}],"title":"Direct ETTIN-auxin interaction controls chromatin states in gynoecium development","department":[{"_id":"JiFr"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"file":[{"access_level":"open_access","relation":"main_file","date_updated":"2020-07-14T12:48:03Z","date_created":"2020-05-04T09:06:43Z","checksum":"15d740de1a741fdcc6ec128c48eed017","file_id":"7794","creator":"dernst","file_name":"2020_eLife_Kuhn.pdf","file_size":2893082,"content_type":"application/pdf"}],"intvolume":"         9","publisher":"eLife Sciences Publications","type":"journal_article","status":"public","date_updated":"2023-08-21T06:17:12Z","doi":"10.7554/elife.51787","pmid":1,"year":"2020","_id":"7793","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_type":"original","isi":1,"date_created":"2020-05-04T08:50:47Z","publication_identifier":{"issn":["2050-084X"]},"quality_controlled":"1","language":[{"iso":"eng"}],"date_published":"2020-04-08T00:00:00Z","file_date_updated":"2020-07-14T12:48:03Z","citation":{"chicago":"Kuhn, André, Sigurd Ramans Harborough, Heather M McLaughlin, Bhavani Natarajan, Inge Verstraeten, Jiří Friml, Stefan Kepinski, and Lars Østergaard. “Direct ETTIN-Auxin Interaction Controls Chromatin States in Gynoecium Development.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/elife.51787\">https://doi.org/10.7554/elife.51787</a>.","ama":"Kuhn A, Ramans Harborough S, McLaughlin HM, et al. Direct ETTIN-auxin interaction controls chromatin states in gynoecium development. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/elife.51787\">10.7554/elife.51787</a>","ieee":"A. Kuhn <i>et al.</i>, “Direct ETTIN-auxin interaction controls chromatin states in gynoecium development,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020.","mla":"Kuhn, André, et al. “Direct ETTIN-Auxin Interaction Controls Chromatin States in Gynoecium Development.” <i>ELife</i>, vol. 9, e51787, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/elife.51787\">10.7554/elife.51787</a>.","apa":"Kuhn, A., Ramans Harborough, S., McLaughlin, H. M., Natarajan, B., Verstraeten, I., Friml, J., … Østergaard, L. (2020). Direct ETTIN-auxin interaction controls chromatin states in gynoecium development. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/elife.51787\">https://doi.org/10.7554/elife.51787</a>","short":"A. Kuhn, S. Ramans Harborough, H.M. McLaughlin, B. Natarajan, I. Verstraeten, J. Friml, S. Kepinski, L. Østergaard, ELife 9 (2020).","ista":"Kuhn A, Ramans Harborough S, McLaughlin HM, Natarajan B, Verstraeten I, Friml J, Kepinski S, Østergaard L. 2020. Direct ETTIN-auxin interaction controls chromatin states in gynoecium development. eLife. 9, e51787."},"volume":9,"article_processing_charge":"No","month":"04","oa":1},{"date_published":"2020-07-01T00:00:00Z","oa":1,"article_processing_charge":"No","month":"07","citation":{"short":"A. Czumaj, P. Davies, M. Parter, in:, Proceedings of the 32nd ACM Symposium on Parallelism in Algorithms and Architectures (SPAA 2020), Association for Computing Machinery, 2020, pp. 175–185.","ista":"Czumaj A, Davies P, Parter M. 2020. Graph sparsification for derandomizing massively parallel computation with low space. Proceedings of the 32nd ACM Symposium on Parallelism in Algorithms and Architectures (SPAA 2020). SPAA: Symposium on Parallelism in Algorithms and Architectures, 175–185.","ieee":"A. Czumaj, P. Davies, and M. Parter, “Graph sparsification for derandomizing massively parallel computation with low space,” in <i>Proceedings of the 32nd ACM Symposium on Parallelism in Algorithms and Architectures (SPAA 2020)</i>, Virtual Event, United States, 2020, no. 7, pp. 175–185.","mla":"Czumaj, Artur, et al. “Graph Sparsification for Derandomizing Massively Parallel Computation with Low Space.” <i>Proceedings of the 32nd ACM Symposium on Parallelism in Algorithms and Architectures (SPAA 2020)</i>, no. 7, Association for Computing Machinery, 2020, pp. 175–85, doi:<a href=\"https://doi.org/10.1145/3350755.3400282\">10.1145/3350755.3400282</a>.","apa":"Czumaj, A., Davies, P., &#38; Parter, M. (2020). Graph sparsification for derandomizing massively parallel computation with low space. In <i>Proceedings of the 32nd ACM Symposium on Parallelism in Algorithms and Architectures (SPAA 2020)</i> (pp. 175–185). Virtual Event, United States: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3350755.3400282\">https://doi.org/10.1145/3350755.3400282</a>","ama":"Czumaj A, Davies P, Parter M. Graph sparsification for derandomizing massively parallel computation with low space. In: <i>Proceedings of the 32nd ACM Symposium on Parallelism in Algorithms and Architectures (SPAA 2020)</i>. Association for Computing Machinery; 2020:175-185. doi:<a href=\"https://doi.org/10.1145/3350755.3400282\">10.1145/3350755.3400282</a>","chicago":"Czumaj, Artur, Peter Davies, and Merav Parter. “Graph Sparsification for Derandomizing Massively Parallel Computation with Low Space.” In <i>Proceedings of the 32nd ACM Symposium on Parallelism in Algorithms and Architectures (SPAA 2020)</i>, 175–85. Association for Computing Machinery, 2020. <a href=\"https://doi.org/10.1145/3350755.3400282\">https://doi.org/10.1145/3350755.3400282</a>."},"arxiv":1,"date_created":"2020-05-06T08:53:34Z","conference":{"start_date":"2020-07-15","location":"Virtual Event, United States","end_date":"2020-07-17","name":"SPAA: Symposium on Parallelism in Algorithms and Architectures"},"language":[{"iso":"eng"}],"quality_controlled":"1","_id":"7802","page":"175-185","year":"2020","isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2025-04-15T06:54:47Z","type":"conference","publisher":"Association for Computing Machinery","status":"public","doi":"10.1145/3350755.3400282","title":"Graph sparsification for derandomizing massively parallel computation with low space","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1912.05390"}],"department":[{"_id":"DaAl"}],"external_id":{"arxiv":["1912.05390"],"isi":["000744436200015"]},"author":[{"last_name":"Czumaj","full_name":"Czumaj, Artur","first_name":"Artur","orcid":"0000-0002-5646-9524"},{"first_name":"Peter","id":"11396234-BB50-11E9-B24C-90FCE5697425","full_name":"Davies, Peter","last_name":"Davies","orcid":"0000-0002-5646-9524"},{"first_name":"Merav","last_name":"Parter","full_name":"Parter, Merav"}],"ec_funded":1,"oa_version":"Preprint","publication":"Proceedings of the 32nd ACM Symposium on Parallelism in Algorithms and Architectures (SPAA 2020)","issue":"7","day":"01","abstract":[{"lang":"eng","text":"The Massively Parallel Computation (MPC) model is an emerging model which distills core  aspects of distributed and parallel computation. It has been developed as a tool to solve (typically graph) problems in systems where the input is distributed over many machines with limited space.\r\n\t\r\nRecent work has focused on the regime in which machines have sublinear (in $n$, the number of nodes in the input graph) space, with randomized algorithms presented for fundamental graph problems of Maximal Matching and Maximal Independent Set. However, there have been no prior corresponding deterministic algorithms.\r\n\t\r\n\tA major challenge underlying the sublinear space setting is that the local space of each machine might be too small to store all the edges incident to a single node. This poses a considerable obstacle compared to the classical models in which each node is assumed to know and have easy access to its incident edges. To overcome this barrier we introduce a new graph sparsification technique that deterministically computes a low-degree subgraph with additional desired properties. The degree of the nodes in this subgraph is small in the sense that the edges of each node can be now stored on a single machine. This low-degree subgraph also has the property that solving the problem on this subgraph provides \\emph{significant} global progress, i.e., progress towards solving the problem for the original input graph.\r\n\t\r\nUsing this framework to derandomize the well-known randomized algorithm of Luby [SICOMP'86], we obtain $O(\\log \\Delta+\\log\\log n)$-round deterministic MPC algorithms for solving the fundamental problems of Maximal Matching and Maximal Independent Set with $O(n^{\\epsilon})$ space on each machine for any constant $\\epsilon > 0$. Based on the recent work of Ghaffari et al. [FOCS'18], this additive $O(\\log\\log n)$ factor is conditionally essential. These algorithms can also be shown to run in $O(\\log \\Delta)$ rounds in the closely related model of CONGESTED CLIQUE, improving upon the state-of-the-art bound of $O(\\log^2 \\Delta)$ rounds by Censor-Hillel et al. [DISC'17]."}],"project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","grant_number":"754411"}],"publication_status":"published","scopus_import":"1","related_material":{"record":[{"relation":"later_version","status":"public","id":"9541"}]}},{"isi":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"7803","page":"309-318","year":"2020","doi":"10.1145/3382734.3405751","date_updated":"2025-09-10T10:18:18Z","publisher":"Association for Computing Machinery","status":"public","type":"conference","oa":1,"article_processing_charge":"No","month":"07","citation":{"short":"A. Czumaj, P. Davies, M. Parter, in:, Proceedings of the 2020 ACM Symposium on Principles of Distributed Computing, Association for Computing Machinery, 2020, pp. 309–318.","ista":"Czumaj A, Davies P, Parter M. 2020. Simple, deterministic, constant-round coloring in the congested clique. Proceedings of the 2020 ACM Symposium on Principles of Distributed Computing. PODC: Symposium on Principles of Distributed Computing, 309–318.","mla":"Czumaj, Artur, et al. “Simple, Deterministic, Constant-Round Coloring in the Congested Clique.” <i>Proceedings of the 2020 ACM Symposium on Principles of Distributed Computing</i>, Association for Computing Machinery, 2020, pp. 309–18, doi:<a href=\"https://doi.org/10.1145/3382734.3405751\">10.1145/3382734.3405751</a>.","ieee":"A. Czumaj, P. Davies, and M. Parter, “Simple, deterministic, constant-round coloring in the congested clique,” in <i>Proceedings of the 2020 ACM Symposium on Principles of Distributed Computing</i>, Salerno, Italy, 2020, pp. 309–318.","apa":"Czumaj, A., Davies, P., &#38; Parter, M. (2020). Simple, deterministic, constant-round coloring in the congested clique. In <i>Proceedings of the 2020 ACM Symposium on Principles of Distributed Computing</i> (pp. 309–318). Salerno, Italy: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3382734.3405751\">https://doi.org/10.1145/3382734.3405751</a>","ama":"Czumaj A, Davies P, Parter M. Simple, deterministic, constant-round coloring in the congested clique. In: <i>Proceedings of the 2020 ACM Symposium on Principles of Distributed Computing</i>. Association for Computing Machinery; 2020:309-318. doi:<a href=\"https://doi.org/10.1145/3382734.3405751\">10.1145/3382734.3405751</a>","chicago":"Czumaj, Artur, Peter Davies, and Merav Parter. “Simple, Deterministic, Constant-Round Coloring in the Congested Clique.” In <i>Proceedings of the 2020 ACM Symposium on Principles of Distributed Computing</i>, 309–18. Association for Computing Machinery, 2020. <a href=\"https://doi.org/10.1145/3382734.3405751\">https://doi.org/10.1145/3382734.3405751</a>."},"file_date_updated":"2020-10-08T08:17:36Z","date_published":"2020-07-01T00:00:00Z","language":[{"iso":"eng"}],"quality_controlled":"1","arxiv":1,"date_created":"2020-05-06T09:02:14Z","conference":{"start_date":"2020-08-03","location":"Salerno, Italy","name":"PODC: Symposium on Principles of Distributed Computing","end_date":"2020-08-07"},"publication":"Proceedings of the 2020 ACM Symposium on Principles of Distributed Computing","ddc":["000"],"abstract":[{"text":"We settle the complexity of the (Δ+1)-coloring and (Δ+1)-list coloring problems in the CONGESTED CLIQUE model by presenting a simple deterministic algorithm for both problems running in a constant number of rounds. This matches the complexity of the recent breakthrough randomized constant-round (Δ+1)-list coloring algorithm due to Chang et al. (PODC'19), and significantly improves upon the state-of-the-art O(logΔ)-round deterministic (Δ+1)-coloring bound of Parter (ICALP'18).\r\nA remarkable property of our algorithm is its simplicity. Whereas the state-of-the-art randomized algorithms for this problem are based on the quite involved local coloring algorithm of Chang et al. (STOC'18), our algorithm can be described in just a few lines. At a high level, it applies a careful derandomization of a recursive procedure which partitions the nodes and their respective palettes into separate bins. We show that after O(1) recursion steps, the remaining uncolored subgraph within each bin has linear size, and thus can be solved locally by collecting it to a single node. This algorithm can also be implemented in the Massively Parallel Computation (MPC) model provided that each machine has linear (in n, the number of nodes in the input graph) space.\r\nWe also show an extension of our algorithm to the MPC regime in which machines have sublinear space: we present the first deterministic (Δ+1)-list coloring algorithm designed for sublinear-space MPC, which runs in O(logΔ+loglogn) rounds.","lang":"eng"}],"day":"01","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"ec_funded":1,"oa_version":"Submitted Version","has_accepted_license":"1","publication_status":"published","scopus_import":"1","file":[{"success":1,"file_name":"ColoringArxiv.pdf","date_created":"2020-10-08T08:17:36Z","date_updated":"2020-10-08T08:17:36Z","relation":"main_file","access_level":"open_access","checksum":"46fe4fc58a64eb04068115573f631d4c","file_id":"8624","creator":"pdavies","file_size":520051,"content_type":"application/pdf"}],"department":[{"_id":"DaAl"}],"title":"Simple, deterministic, constant-round coloring in the congested clique","author":[{"orcid":"0000-0002-5646-9524","full_name":"Czumaj, Artur","last_name":"Czumaj","first_name":"Artur"},{"full_name":"Davies, Peter","last_name":"Davies","id":"11396234-BB50-11E9-B24C-90FCE5697425","first_name":"Peter","orcid":"0000-0002-5646-9524"},{"first_name":"Merav","full_name":"Parter, Merav","last_name":"Parter"}],"external_id":{"isi":["001436693500042"],"arxiv":["2009.06043"]}},{"date_created":"2020-05-10T22:00:48Z","conference":{"start_date":"2020-01-05","location":"Salt Lake City, UT, United States","name":"SODA: Symposium on Discrete Algorithms","end_date":"2020-01-08"},"language":[{"iso":"eng"}],"publication_identifier":{"isbn":["9781611975994"]},"quality_controlled":"1","date_published":"2020-01-01T00:00:00Z","month":"01","volume":"2020-January","article_processing_charge":"No","oa":1,"citation":{"short":"M. Filakovský, U. Wagner, S.Y. Zhechev, in:, Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2020, pp. 767–785.","ista":"Filakovský M, Wagner U, Zhechev SY. 2020. Embeddability of simplicial complexes is undecidable. Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms vol. 2020–January, 767–785.","mla":"Filakovský, Marek, et al. “Embeddability of Simplicial Complexes Is Undecidable.” <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i>, vol. 2020–January, SIAM, 2020, pp. 767–85, doi:<a href=\"https://doi.org/10.1137/1.9781611975994.47\">10.1137/1.9781611975994.47</a>.","ieee":"M. Filakovský, U. Wagner, and S. Y. Zhechev, “Embeddability of simplicial complexes is undecidable,” in <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Salt Lake City, UT, United States, 2020, vol. 2020–January, pp. 767–785.","apa":"Filakovský, M., Wagner, U., &#38; Zhechev, S. Y. (2020). Embeddability of simplicial complexes is undecidable. In <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i> (Vol. 2020–January, pp. 767–785). Salt Lake City, UT, United States: SIAM. <a href=\"https://doi.org/10.1137/1.9781611975994.47\">https://doi.org/10.1137/1.9781611975994.47</a>","ama":"Filakovský M, Wagner U, Zhechev SY. Embeddability of simplicial complexes is undecidable. In: <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i>. Vol 2020-January. SIAM; 2020:767-785. doi:<a href=\"https://doi.org/10.1137/1.9781611975994.47\">10.1137/1.9781611975994.47</a>","chicago":"Filakovský, Marek, Uli Wagner, and Stephan Y Zhechev. “Embeddability of Simplicial Complexes Is Undecidable.” In <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i>, 2020–January:767–85. SIAM, 2020. <a href=\"https://doi.org/10.1137/1.9781611975994.47\">https://doi.org/10.1137/1.9781611975994.47</a>."},"type":"conference","publisher":"SIAM","status":"public","date_updated":"2021-01-12T08:15:38Z","doi":"10.1137/1.9781611975994.47","page":"767-785","_id":"7806","year":"2020","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Marek","last_name":"Filakovský","id":"3E8AF77E-F248-11E8-B48F-1D18A9856A87","full_name":"Filakovský, Marek"},{"first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","full_name":"Wagner, Uli","last_name":"Wagner","orcid":"0000-0002-1494-0568"},{"full_name":"Zhechev, Stephan Y","id":"3AA52972-F248-11E8-B48F-1D18A9856A87","first_name":"Stephan Y","last_name":"Zhechev"}],"title":"Embeddability of simplicial complexes is undecidable","main_file_link":[{"url":"https://doi.org/10.1137/1.9781611975994.47","open_access":"1"}],"department":[{"_id":"UlWa"}],"publication_status":"published","scopus_import":1,"oa_version":"Published Version","publication":"Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms","project":[{"_id":"26611F5C-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Algorithms for Embeddings and Homotopy Theory","grant_number":"P31312"}],"abstract":[{"lang":"eng","text":"We consider the following decision problem EMBEDk→d in computational topology (where k ≤ d are fixed positive integers): Given a finite simplicial complex K of dimension k, does there exist a (piecewise-linear) embedding of K into ℝd?\r\nThe special case EMBED1→2 is graph planarity, which is decidable in linear time, as shown by Hopcroft and Tarjan. In higher dimensions, EMBED2→3 and EMBED3→3 are known to be decidable (as well as NP-hard), and recent results of Čadek et al. in computational homotopy theory, in combination with the classical Haefliger–Weber theorem in geometric topology, imply that EMBEDk→d can be solved in polynomial time for any fixed pair (k, d) of dimensions in the so-called metastable range .\r\nHere, by contrast, we prove that EMBEDk→d is algorithmically undecidable for almost all pairs of dimensions outside the metastable range, namely for . This almost completely resolves the decidability vs. undecidability of EMBEDk→d in higher dimensions and establishes a sharp dichotomy between polynomial-time solvability and undecidability.\r\nOur result complements (and in a wide range of dimensions strengthens) earlier results of Matoušek, Tancer, and the second author, who showed that EMBEDk→d is undecidable for 4 ≤ k ϵ {d – 1, d}, and NP-hard for all remaining pairs (k, d) outside the metastable range and satisfying d ≥ 4."}],"day":"01"},{"external_id":{"arxiv":["2003.13557"]},"author":[{"first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","full_name":"Wagner, Uli","orcid":"0000-0002-1494-0568"},{"full_name":"Welzl, Emo","last_name":"Welzl","first_name":"Emo"}],"title":"Connectivity of triangulation flip graphs in the plane (Part I: Edge flips)","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1137/1.9781611975994.172"}],"department":[{"_id":"UlWa"}],"publication_status":"published","scopus_import":1,"related_material":{"record":[{"id":"12129","status":"public","relation":"later_version"}]},"oa_version":"Submitted Version","publication":"Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms","abstract":[{"text":"In a straight-line embedded triangulation of a point set P in the plane, removing an inner edge and—provided the resulting quadrilateral is convex—adding the other diagonal is called an edge flip. The (edge) flip graph has all triangulations as vertices, and a pair of triangulations is adjacent if they can be obtained from each other by an edge flip. The goal of this paper is to contribute to a better understanding of the flip graph, with an emphasis on its connectivity.\r\nFor sets in general position, it is known that every triangulation allows at least edge flips (a tight bound) which gives the minimum degree of any flip graph for n points. We show that for every point set P in general position, the flip graph is at least -vertex connected. Somewhat more strongly, we show that the vertex connectivity equals the minimum degree occurring in the flip graph, i.e. the minimum number of flippable edges in any triangulation of P, provided P is large enough. Finally, we exhibit some of the geometry of the flip graph by showing that the flip graph can be covered by 1-skeletons of polytopes of dimension (products of associahedra).\r\nA corresponding result ((n – 3)-vertex connectedness) can be shown for the bistellar flip graph of partial triangulations, i.e. the set of all triangulations of subsets of P which contain all extreme points of P. This will be treated separately in a second part.","lang":"eng"}],"day":"01","arxiv":1,"date_created":"2020-05-10T22:00:48Z","conference":{"end_date":"2020-01-08","name":"SODA: Symposium on Discrete Algorithms","location":"Salt Lake City, UT, United States","start_date":"2020-01-05"},"language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"isbn":["9781611975994"]},"date_published":"2020-01-01T00:00:00Z","oa":1,"volume":"2020-January","article_processing_charge":"No","month":"01","citation":{"ama":"Wagner U, Welzl E. Connectivity of triangulation flip graphs in the plane (Part I: Edge flips). In: <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i>. Vol 2020-January. SIAM; 2020:2823-2841. doi:<a href=\"https://doi.org/10.1137/1.9781611975994.172\">10.1137/1.9781611975994.172</a>","chicago":"Wagner, Uli, and Emo Welzl. “Connectivity of Triangulation Flip Graphs in the Plane (Part I: Edge Flips).” In <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i>, 2020–January:2823–41. SIAM, 2020. <a href=\"https://doi.org/10.1137/1.9781611975994.172\">https://doi.org/10.1137/1.9781611975994.172</a>.","apa":"Wagner, U., &#38; Welzl, E. (2020). Connectivity of triangulation flip graphs in the plane (Part I: Edge flips). In <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i> (Vol. 2020–January, pp. 2823–2841). Salt Lake City, UT, United States: SIAM. <a href=\"https://doi.org/10.1137/1.9781611975994.172\">https://doi.org/10.1137/1.9781611975994.172</a>","ieee":"U. Wagner and E. Welzl, “Connectivity of triangulation flip graphs in the plane (Part I: Edge flips),” in <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Salt Lake City, UT, United States, 2020, vol. 2020–January, pp. 2823–2841.","mla":"Wagner, Uli, and Emo Welzl. “Connectivity of Triangulation Flip Graphs in the Plane (Part I: Edge Flips).” <i>Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms</i>, vol. 2020–January, SIAM, 2020, pp. 2823–41, doi:<a href=\"https://doi.org/10.1137/1.9781611975994.172\">10.1137/1.9781611975994.172</a>.","ista":"Wagner U, Welzl E. 2020. Connectivity of triangulation flip graphs in the plane (Part I: Edge flips). Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms vol. 2020–January, 2823–2841.","short":"U. Wagner, E. Welzl, in:, Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2020, pp. 2823–2841."},"date_updated":"2024-10-09T21:03:33Z","type":"conference","publisher":"SIAM","status":"public","doi":"10.1137/1.9781611975994.172","_id":"7807","page":"2823-2841","year":"2020","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"date_updated":"2024-10-22T10:46:38Z","type":"journal_article","status":"public","publisher":"Frontiers Media","intvolume":"         5","doi":"10.3389/feduc.2020.00048","_id":"7814","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"PreCl"},{"_id":"EM-Fac"}],"year":"2020","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2020-05-11T08:18:48Z","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"issn":["2504-284X"]},"file_date_updated":"2020-07-14T12:48:03Z","date_published":"2020-05-08T00:00:00Z","oa":1,"month":"05","article_processing_charge":"No","volume":5,"citation":{"short":"R.J. Beattie, S. Hippenmeyer, F. Pauler, Frontiers in Education 5 (2020).","ista":"Beattie RJ, Hippenmeyer S, Pauler F. 2020. SCOPES: Sparking curiosity through Open-Source platforms in education and science. Frontiers in Education. 5, 48.","mla":"Beattie, Robert J., et al. “SCOPES: Sparking Curiosity through Open-Source Platforms in Education and Science.” <i>Frontiers in Education</i>, vol. 5, 48, Frontiers Media, 2020, doi:<a href=\"https://doi.org/10.3389/feduc.2020.00048\">10.3389/feduc.2020.00048</a>.","ieee":"R. J. Beattie, S. Hippenmeyer, and F. Pauler, “SCOPES: Sparking curiosity through Open-Source platforms in education and science,” <i>Frontiers in Education</i>, vol. 5. Frontiers Media, 2020.","apa":"Beattie, R. J., Hippenmeyer, S., &#38; Pauler, F. (2020). SCOPES: Sparking curiosity through Open-Source platforms in education and science. <i>Frontiers in Education</i>. Frontiers Media. <a href=\"https://doi.org/10.3389/feduc.2020.00048\">https://doi.org/10.3389/feduc.2020.00048</a>","ama":"Beattie RJ, Hippenmeyer S, Pauler F. SCOPES: Sparking curiosity through Open-Source platforms in education and science. <i>Frontiers in Education</i>. 2020;5. doi:<a href=\"https://doi.org/10.3389/feduc.2020.00048\">10.3389/feduc.2020.00048</a>","chicago":"Beattie, Robert J, Simon Hippenmeyer, and Florian Pauler. “SCOPES: Sparking Curiosity through Open-Source Platforms in Education and Science.” <i>Frontiers in Education</i>. Frontiers Media, 2020. <a href=\"https://doi.org/10.3389/feduc.2020.00048\">https://doi.org/10.3389/feduc.2020.00048</a>."},"corr_author":"1","publication_status":"published","scopus_import":"1","article_number":"48","has_accepted_license":"1","ec_funded":1,"oa_version":"Published Version","publication":"Frontiers in Education","ddc":["570"],"abstract":[{"lang":"eng","text":"Scientific research is to date largely restricted to wealthy laboratories in developed nations due to the necessity of complex and expensive equipment. This inequality limits the capacity of science to be used as a diplomatic channel. Maker movements use open-source technologies including additive manufacturing (3D printing) and laser cutting, together with low-cost computers for developing novel products. This movement is setting the groundwork for a revolution, allowing scientific equipment to be sourced at a fraction of the cost and has the potential to increase the availability of equipment for scientists around the world. Science education is increasingly recognized as another channel for science diplomacy. In this perspective, we introduce the idea that the Maker movement and open-source technologies have the potential to revolutionize science, technology, engineering and mathematics (STEM) education worldwide. We present an open-source STEM didactic tool called SCOPES (Sparking Curiosity through Open-source Platforms in Education and Science). SCOPES is self-contained, independent of local resources, and cost-effective. SCOPES can be adapted to communicate complex subjects from genetics to neurobiology, perform real-world biological experiments and explore digitized scientific samples. We envision such platforms will enhance science diplomacy by providing a means for scientists to share their findings with classrooms and for educators to incorporate didactic concepts into STEM lessons. By providing students the opportunity to design, perform, and share scientific experiments, students also experience firsthand the benefits of a multinational scientific community. We provide instructions on how to build and use SCOPES on our webpage: http://scopeseducation.org."}],"day":"08","project":[{"_id":"264E56E2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Molecular Mechanisms Regulating Gliogenesis in the Neocortex","grant_number":"M02416"},{"grant_number":"725780","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425"}],"author":[{"orcid":"0000-0002-8483-8753","last_name":"Beattie","full_name":"Beattie, Robert J","id":"2E26DF60-F248-11E8-B48F-1D18A9856A87","first_name":"Robert J"},{"orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Pauler","full_name":"Pauler, Florian","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","first_name":"Florian","orcid":"0000-0002-7462-0048"}],"title":"SCOPES: Sparking curiosity through Open-Source platforms in education and science","file":[{"file_size":1402146,"content_type":"application/pdf","date_created":"2020-05-11T11:34:08Z","date_updated":"2020-07-14T12:48:03Z","access_level":"open_access","relation":"main_file","checksum":"a24ec24e38d843341ae620ec76c53688","creator":"dernst","file_id":"7818","file_name":"2020_FrontiersEduc_Beattie.pdf"}],"department":[{"_id":"SiHi"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"}},{"external_id":{"pmid":["32390281"],"isi":["000541488700001"]},"author":[{"full_name":"Bouchal, Roza","last_name":"Bouchal","first_name":"Roza"},{"full_name":"Li, Zhujie","last_name":"Li","first_name":"Zhujie"},{"full_name":"Bongu, Chandra","last_name":"Bongu","first_name":"Chandra"},{"last_name":"Le Vot","full_name":"Le Vot, Steven","first_name":"Steven"},{"full_name":"Berthelot, Romain","first_name":"Romain","last_name":"Berthelot"},{"last_name":"Rotenberg","first_name":"Benjamin","full_name":"Rotenberg, Benjamin"},{"first_name":"Fréderic","last_name":"Favier","full_name":"Favier, Fréderic"},{"first_name":"Stefan Alexander","full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","last_name":"Freunberger","orcid":"0000-0003-2902-5319"},{"last_name":"Salanne","first_name":"Mathieu","full_name":"Salanne, Mathieu"},{"first_name":"Olivier","last_name":"Fontaine","full_name":"Fontaine, Olivier"}],"title":"Competitive salt precipitation/dissolution during free‐water reduction in water‐in‐salt electrolyte","file":[{"content_type":"application/pdf","file_size":1966184,"creator":"dernst","file_id":"8400","checksum":"7b6c2fc20e9b0ff4353352f7a7004e2d","date_created":"2020-09-17T08:57:16Z","access_level":"open_access","relation":"main_file","date_updated":"2020-09-17T08:57:16Z","file_name":"2020_AngChemieINT_Buchal.pdf","success":1}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"StFr"}],"publication_status":"published","scopus_import":"1","has_accepted_license":"1","oa_version":"Published Version","issue":"37","publication":"Angewandte Chemie International Edition","day":"07","abstract":[{"lang":"eng","text":"Water-in-salt electrolytes based on highly concentrated bis(trifluoromethyl)sulfonimide (TFSI) promise aqueous electrolytes with stabilities nearing 3 V. However, especially with an electrode approaching the cathodic (reductive) stability, cycling stability is insufficient. While stability critically relies on a solid electrolyte interphase (SEI), the mechanism behind the cathodic stability limit remains unclear. Here, we reveal two distinct reduction potentials for the chemical environments of 'free' and 'bound' water and that both contribute to SEI formation. Free-water is reduced ~1V above bound water in a hydrogen evolution reaction (HER) and responsible for SEI formation via reactive intermediates of the HER; concurrent LiTFSI precipitation/dissolution establishes a dynamic interface. The free-water population emerges, therefore, as the handle to extend the cathodic limit of aqueous electrolytes and the battery cycling stability. "}],"ddc":["540","546"],"date_created":"2020-05-14T21:00:30Z","language":[{"iso":"eng"}],"publication_identifier":{"issn":["1433-7851"],"eissn":["1521-3773"]},"quality_controlled":"1","file_date_updated":"2020-09-17T08:57:16Z","date_published":"2020-09-07T00:00:00Z","article_processing_charge":"No","month":"09","volume":59,"oa":1,"citation":{"short":"R. Bouchal, Z. Li, C. Bongu, S. Le Vot, R. Berthelot, B. Rotenberg, F. Favier, S.A. Freunberger, M. Salanne, O. Fontaine, Angewandte Chemie International Edition 59 (2020) 15913–1591.","ista":"Bouchal R, Li Z, Bongu C, Le Vot S, Berthelot R, Rotenberg B, Favier F, Freunberger SA, Salanne M, Fontaine O. 2020. Competitive salt precipitation/dissolution during free‐water reduction in water‐in‐salt electrolyte. Angewandte Chemie International Edition. 59(37), 15913–1591.","chicago":"Bouchal, Roza, Zhujie Li, Chandra Bongu, Steven Le Vot, Romain Berthelot, Benjamin Rotenberg, Fréderic Favier, Stefan Alexander Freunberger, Mathieu Salanne, and Olivier Fontaine. “Competitive Salt Precipitation/Dissolution during Free‐water Reduction in Water‐in‐salt Electrolyte.” <i>Angewandte Chemie International Edition</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/anie.202005378\">https://doi.org/10.1002/anie.202005378</a>.","ama":"Bouchal R, Li Z, Bongu C, et al. Competitive salt precipitation/dissolution during free‐water reduction in water‐in‐salt electrolyte. <i>Angewandte Chemie International Edition</i>. 2020;59(37):15913-1591. doi:<a href=\"https://doi.org/10.1002/anie.202005378\">10.1002/anie.202005378</a>","mla":"Bouchal, Roza, et al. “Competitive Salt Precipitation/Dissolution during Free‐water Reduction in Water‐in‐salt Electrolyte.” <i>Angewandte Chemie International Edition</i>, vol. 59, no. 37, Wiley, 2020, pp. 15913–1591, doi:<a href=\"https://doi.org/10.1002/anie.202005378\">10.1002/anie.202005378</a>.","ieee":"R. Bouchal <i>et al.</i>, “Competitive salt precipitation/dissolution during free‐water reduction in water‐in‐salt electrolyte,” <i>Angewandte Chemie International Edition</i>, vol. 59, no. 37. Wiley, pp. 15913–1591, 2020.","apa":"Bouchal, R., Li, Z., Bongu, C., Le Vot, S., Berthelot, R., Rotenberg, B., … Fontaine, O. (2020). Competitive salt precipitation/dissolution during free‐water reduction in water‐in‐salt electrolyte. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.202005378\">https://doi.org/10.1002/anie.202005378</a>"},"status":"public","type":"journal_article","publisher":"Wiley","date_updated":"2023-09-05T16:02:53Z","intvolume":"        59","doi":"10.1002/anie.202005378","page":"15913-1591","_id":"7847","year":"2020","pmid":1,"article_type":"original","isi":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"_id":"7864","page":"282-289","year":"2020","isi":1,"article_type":"original","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-21T06:28:52Z","status":"public","publisher":"Wolters Kluwer","type":"journal_article","intvolume":"        20","doi":"10.1097/ACI.0000000000000637","date_published":"2020-06-01T00:00:00Z","article_processing_charge":"No","month":"06","volume":20,"citation":{"short":"J. Singer, J. Singer, E. Jensen-Jarolim, Current Opinion in Allergy and Clinical Immunology 20 (2020) 282–289.","ista":"Singer J, Singer J, Jensen-Jarolim E. 2020. Precision medicine in clinical oncology: the journey from IgG antibody to IgE. Current opinion in allergy and clinical immunology. 20(3), 282–289.","mla":"Singer, Judit, et al. “Precision Medicine in Clinical Oncology: The Journey from IgG Antibody to IgE.” <i>Current Opinion in Allergy and Clinical Immunology</i>, vol. 20, no. 3, Wolters Kluwer, 2020, pp. 282–89, doi:<a href=\"https://doi.org/10.1097/ACI.0000000000000637\">10.1097/ACI.0000000000000637</a>.","ieee":"J. Singer, J. Singer, and E. Jensen-Jarolim, “Precision medicine in clinical oncology: the journey from IgG antibody to IgE,” <i>Current opinion in allergy and clinical immunology</i>, vol. 20, no. 3. Wolters Kluwer, pp. 282–289, 2020.","apa":"Singer, J., Singer, J., &#38; Jensen-Jarolim, E. (2020). Precision medicine in clinical oncology: the journey from IgG antibody to IgE. <i>Current Opinion in Allergy and Clinical Immunology</i>. Wolters Kluwer. <a href=\"https://doi.org/10.1097/ACI.0000000000000637\">https://doi.org/10.1097/ACI.0000000000000637</a>","chicago":"Singer, Judit, Josef Singer, and Erika Jensen-Jarolim. “Precision Medicine in Clinical Oncology: The Journey from IgG Antibody to IgE.” <i>Current Opinion in Allergy and Clinical Immunology</i>. Wolters Kluwer, 2020. <a href=\"https://doi.org/10.1097/ACI.0000000000000637\">https://doi.org/10.1097/ACI.0000000000000637</a>.","ama":"Singer J, Singer J, Jensen-Jarolim E. Precision medicine in clinical oncology: the journey from IgG antibody to IgE. <i>Current opinion in allergy and clinical immunology</i>. 2020;20(3):282-289. doi:<a href=\"https://doi.org/10.1097/ACI.0000000000000637\">10.1097/ACI.0000000000000637</a>"},"date_created":"2020-05-17T22:00:44Z","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"eissn":["14736322"]},"oa_version":"None","publication":"Current opinion in allergy and clinical immunology","issue":"3","abstract":[{"text":"Purpose of review: Cancer is one of the leading causes of death and the incidence rates are constantly rising. The heterogeneity of tumors poses a big challenge for the treatment of the disease and natural antibodies additionally affect disease progression. The introduction of engineered mAbs for anticancer immunotherapies has substantially improved progression-free and overall survival of cancer patients, but little efforts have been made to exploit other antibody isotypes than IgG.\r\nRecent findings: In order to improve these therapies, ‘next-generation antibodies’ were engineered to enhance a specific feature of classical antibodies and form a group of highly effective and precise therapy compounds. Advanced antibody approaches include among others antibody-drug conjugates, glyco-engineered and Fc-engineered antibodies, antibody fragments, radioimmunotherapy compounds, bispecific antibodies and alternative (non-IgG) immunoglobulin classes, especially IgE.\r\nSummary: The current review describes solutions for the needs of next-generation antibody therapies through different approaches. Careful selection of the best-suited engineering methodology is a key factor in developing personalized, more specific and more efficient mAbs against cancer to improve the outcomes of cancer patients. We highlight here the large evidence of IgE exploiting a highly cytotoxic effector arm as potential next-generation anticancer immunotherapy.","lang":"eng"}],"day":"01","publication_status":"published","scopus_import":"1","title":"Precision medicine in clinical oncology: the journey from IgG antibody to IgE","department":[{"_id":"Bio"}],"external_id":{"isi":["000561358300010"]},"author":[{"first_name":"Judit","full_name":"Singer, Judit","id":"36432834-F248-11E8-B48F-1D18A9856A87","last_name":"Singer","orcid":"0000-0002-8777-3502"},{"first_name":"Josef","full_name":"Singer, Josef","last_name":"Singer"},{"last_name":"Jensen-Jarolim","full_name":"Jensen-Jarolim, Erika","first_name":"Erika"}]},{"file":[{"creator":"dernst","checksum":"cb0b9c77842ae1214caade7b77e4d82d","file_id":"8801","date_created":"2020-11-24T13:25:13Z","date_updated":"2020-11-24T13:25:13Z","access_level":"open_access","relation":"main_file","success":1,"file_name":"2020_JCellBiol_Kopf.pdf","content_type":"application/pdf","file_size":7536712}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"MiSi"},{"_id":"Bio"},{"_id":"NanoFab"}],"title":"Microtubules control cellular shape and coherence in amoeboid migrating cells","author":[{"full_name":"Kopf, Aglaja","last_name":"Kopf","id":"31DAC7B6-F248-11E8-B48F-1D18A9856A87","first_name":"Aglaja","orcid":"0000-0002-2187-6656"},{"orcid":"0000-0003-2856-3369","id":"3F0587C8-F248-11E8-B48F-1D18A9856A87","first_name":"Jörg","last_name":"Renkawitz","full_name":"Renkawitz, Jörg"},{"orcid":"0000-0001-9843-3522","last_name":"Hauschild","first_name":"Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","full_name":"Hauschild, Robert"},{"full_name":"Girkontaite, Irute","last_name":"Girkontaite","first_name":"Irute"},{"last_name":"Tedford","full_name":"Tedford, Kerry","first_name":"Kerry"},{"first_name":"Jack","full_name":"Merrin, Jack","last_name":"Merrin","id":"4515C308-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5145-4609"},{"first_name":"Oliver","last_name":"Thorn-Seshold","full_name":"Thorn-Seshold, Oliver"},{"last_name":"Trauner","full_name":"Trauner, Dirk","first_name":"Dirk","id":"E8F27F48-3EBA-11E9-92A1-B709E6697425"},{"last_name":"Häcker","first_name":"Hans","full_name":"Häcker, Hans"},{"full_name":"Fischer, Klaus Dieter","last_name":"Fischer","first_name":"Klaus Dieter"},{"first_name":"Eva","last_name":"Kiermaier","id":"3EB04B78-F248-11E8-B48F-1D18A9856A87","full_name":"Kiermaier, Eva","orcid":"0000-0001-6165-5738"},{"full_name":"Sixt, Michael K","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","orcid":"0000-0002-6620-9179"}],"external_id":{"isi":["000538141100020"],"pmid":["32379884"]},"publication":"The Journal of Cell Biology","issue":"6","project":[{"grant_number":"281556","name":"Cytoskeletal force generation and force transduction of migrating leukocytes","call_identifier":"FP7","_id":"25A603A2-B435-11E9-9278-68D0E5697425"},{"grant_number":"724373","call_identifier":"H2020","name":"Cellular Navigation Along Spatial Gradients","_id":"25FE9508-B435-11E9-9278-68D0E5697425"},{"_id":"26018E70-B435-11E9-9278-68D0E5697425","name":"Mechanical adaptation of lamellipodial actin","call_identifier":"FWF","grant_number":"P29911"},{"grant_number":"W1250-B20","name":"Nano-Analytics of Cellular Systems","call_identifier":"FWF","_id":"252C3B08-B435-11E9-9278-68D0E5697425"},{"_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"},{"name":"Molecular and system level view of immune cell migration","_id":"25A48D24-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 1396-2014"}],"day":"01","ddc":["570"],"abstract":[{"lang":"eng","text":"Cells navigating through complex tissues face a fundamental challenge: while multiple protrusions explore different paths, the cell needs to avoid entanglement. How a cell surveys and then corrects its own shape is poorly understood. Here, we demonstrate that spatially distinct microtubule dynamics regulate amoeboid cell migration by locally promoting the retraction of protrusions. In migrating dendritic cells, local microtubule depolymerization within protrusions remote from the microtubule organizing center triggers actomyosin contractility controlled by RhoA and its exchange factor Lfc. Depletion of Lfc leads to aberrant myosin localization, thereby causing two effects that rate-limit locomotion: (1) impaired cell edge coordination during path finding and (2) defective adhesion resolution. Compromised shape control is particularly hindering in geometrically complex microenvironments, where it leads to entanglement and ultimately fragmentation of the cell body. We thus demonstrate that microtubules can act as a proprioceptive device: they sense cell shape and control actomyosin retraction to sustain cellular coherence."}],"ec_funded":1,"oa_version":"Published Version","article_number":"e201907154","has_accepted_license":"1","corr_author":"1","publication_status":"published","scopus_import":"1","article_processing_charge":"No","volume":219,"month":"06","oa":1,"citation":{"ista":"Kopf A, Renkawitz J, Hauschild R, Girkontaite I, Tedford K, Merrin J, Thorn-Seshold O, Trauner D, Häcker H, Fischer KD, Kiermaier E, Sixt MK. 2020. Microtubules control cellular shape and coherence in amoeboid migrating cells. The Journal of Cell Biology. 219(6), e201907154.","short":"A. Kopf, J. Renkawitz, R. Hauschild, I. Girkontaite, K. Tedford, J. Merrin, O. Thorn-Seshold, D. Trauner, H. Häcker, K.D. Fischer, E. Kiermaier, M.K. Sixt, The Journal of Cell Biology 219 (2020).","chicago":"Kopf, Aglaja, Jörg Renkawitz, Robert Hauschild, Irute Girkontaite, Kerry Tedford, Jack Merrin, Oliver Thorn-Seshold, et al. “Microtubules Control Cellular Shape and Coherence in Amoeboid Migrating Cells.” <i>The Journal of Cell Biology</i>. Rockefeller University Press, 2020. <a href=\"https://doi.org/10.1083/jcb.201907154\">https://doi.org/10.1083/jcb.201907154</a>.","ama":"Kopf A, Renkawitz J, Hauschild R, et al. Microtubules control cellular shape and coherence in amoeboid migrating cells. <i>The Journal of Cell Biology</i>. 2020;219(6). doi:<a href=\"https://doi.org/10.1083/jcb.201907154\">10.1083/jcb.201907154</a>","apa":"Kopf, A., Renkawitz, J., Hauschild, R., Girkontaite, I., Tedford, K., Merrin, J., … Sixt, M. K. (2020). Microtubules control cellular shape and coherence in amoeboid migrating cells. <i>The Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.201907154\">https://doi.org/10.1083/jcb.201907154</a>","mla":"Kopf, Aglaja, et al. “Microtubules Control Cellular Shape and Coherence in Amoeboid Migrating Cells.” <i>The Journal of Cell Biology</i>, vol. 219, no. 6, e201907154, Rockefeller University Press, 2020, doi:<a href=\"https://doi.org/10.1083/jcb.201907154\">10.1083/jcb.201907154</a>.","ieee":"A. Kopf <i>et al.</i>, “Microtubules control cellular shape and coherence in amoeboid migrating cells,” <i>The Journal of Cell Biology</i>, vol. 219, no. 6. Rockefeller University Press, 2020."},"file_date_updated":"2020-11-24T13:25:13Z","date_published":"2020-06-01T00:00:00Z","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"eissn":["1540-8140"]},"date_created":"2020-05-24T22:00:56Z","article_type":"original","isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"PreCl"}],"_id":"7875","year":"2020","pmid":1,"acknowledgement":"The authors thank the Scientific Service Units (Life Sciences, Bioimaging, Preclinical) of the Institute of Science and Technology Austria for excellent support. This work was funded by the European Research Council (ERC StG 281556 and CoG 724373), two grants from the Austrian\r\nScience Fund (FWF; P29911 and DK Nanocell W1250-B20 to M. Sixt) and by the German Research Foundation (DFG SFB1032 project B09) to O. Thorn-Seshold and D. Trauner. J. Renkawitz was supported by ISTFELLOW funding from the People Program (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under the Research Executive Agency grant agreement (291734) and a European Molecular Biology Organization long-term fellowship (ALTF 1396-2014) co-funded by the European Commission (LTFCOFUND2013, GA-2013-609409), E. Kiermaier by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy—EXC 2151—390873048, and H. Hacker by the American Lebanese Syrian Associated ¨Charities. K.-D. Fischer was supported by the Analysis, Imaging and Modelling of Neuronal and Inflammatory Processes graduate school funded by the Ministry of Economics, Science, and Digitisation of the State Saxony-Anhalt and by the European Funds for Social and Regional Development.","doi":"10.1083/jcb.201907154","status":"public","type":"journal_article","publisher":"Rockefeller University Press","date_updated":"2025-04-14T13:10:03Z","intvolume":"       219"},{"external_id":{"pmid":["32433942"],"isi":["000535371100002"]},"author":[{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","first_name":"Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179"},{"full_name":"Lämmermann, Tim","first_name":"Tim","last_name":"Lämmermann"}],"title":"T cells: Bridge-and-channel commute to the white pulp","main_file_link":[{"url":"https://doi.org/10.1016/j.immuni.2020.04.020","open_access":"1"}],"department":[{"_id":"MiSi"}],"publication_status":"published","scopus_import":"1","OA_place":"publisher","oa_version":"Published Version","publication":"Immunity","issue":"5","abstract":[{"text":"In contrast to lymph nodes, the lymphoid regions of the spleen—the white pulp—are located deep within the organ, yielding the trafficking paths of T cells in the white pulp largely invisible. In an intravital microscopy tour de force reported in this issue of Immunity, Chauveau et al. show that T cells perform unidirectional, perivascular migration through the enigmatic marginal zone bridging channels. ","lang":"eng"}],"day":"19","date_created":"2020-05-24T22:00:57Z","language":[{"iso":"eng"}],"publication_identifier":{"issn":["1074-7613"],"eissn":["1097-4180"]},"quality_controlled":"1","date_published":"2020-05-19T00:00:00Z","article_processing_charge":"No","volume":52,"month":"05","oa":1,"citation":{"ista":"Sixt MK, Lämmermann T. 2020. T cells: Bridge-and-channel commute to the white pulp. Immunity. 52(5), 721–723.","short":"M.K. Sixt, T. Lämmermann, Immunity 52 (2020) 721–723.","apa":"Sixt, M. K., &#38; Lämmermann, T. (2020). T cells: Bridge-and-channel commute to the white pulp. <i>Immunity</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.immuni.2020.04.020\">https://doi.org/10.1016/j.immuni.2020.04.020</a>","ieee":"M. K. Sixt and T. Lämmermann, “T cells: Bridge-and-channel commute to the white pulp,” <i>Immunity</i>, vol. 52, no. 5. Elsevier, pp. 721–723, 2020.","mla":"Sixt, Michael K., and Tim Lämmermann. “T Cells: Bridge-and-Channel Commute to the White Pulp.” <i>Immunity</i>, vol. 52, no. 5, Elsevier, 2020, pp. 721–23, doi:<a href=\"https://doi.org/10.1016/j.immuni.2020.04.020\">10.1016/j.immuni.2020.04.020</a>.","ama":"Sixt MK, Lämmermann T. T cells: Bridge-and-channel commute to the white pulp. <i>Immunity</i>. 2020;52(5):721-723. doi:<a href=\"https://doi.org/10.1016/j.immuni.2020.04.020\">10.1016/j.immuni.2020.04.020</a>","chicago":"Sixt, Michael K, and Tim Lämmermann. “T Cells: Bridge-and-Channel Commute to the White Pulp.” <i>Immunity</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.immuni.2020.04.020\">https://doi.org/10.1016/j.immuni.2020.04.020</a>."},"status":"public","publisher":"Elsevier","type":"journal_article","date_updated":"2025-05-19T13:02:07Z","intvolume":"        52","doi":"10.1016/j.immuni.2020.04.020","page":"721-723","_id":"7876","year":"2020","pmid":1,"article_type":"original","OA_type":"free access","isi":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"external_id":{"isi":["000530288000006"],"pmid":["32132171"]},"author":[{"last_name":"Fagan","full_name":"Fagan, Rita R.","first_name":"Rita R."},{"full_name":"Kearney, Patrick J.","first_name":"Patrick J.","last_name":"Kearney"},{"first_name":"Carolyn G.","full_name":"Sweeney, Carolyn G.","last_name":"Sweeney"},{"full_name":"Luethi, Dino","last_name":"Luethi","first_name":"Dino"},{"id":"3526230C-F248-11E8-B48F-1D18A9856A87","last_name":"Schoot Uiterkamp","full_name":"Schoot Uiterkamp, Florianne E","first_name":"Florianne E"},{"full_name":"Schicker, Klaus","last_name":"Schicker","first_name":"Klaus"},{"full_name":"Alejandro, Brian S.","first_name":"Brian S.","last_name":"Alejandro"},{"full_name":"O'Connor, Lauren C.","last_name":"O'Connor","first_name":"Lauren C."},{"full_name":"Sitte, Harald H.","first_name":"Harald H.","last_name":"Sitte"},{"first_name":"Haley E.","full_name":"Melikian, Haley E.","last_name":"Melikian"}],"title":"Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact","main_file_link":[{"url":"https://escholarship.umassmed.edu/oapubs/4187","open_access":"1"}],"department":[{"_id":"SaSi"}],"publication_status":"published","scopus_import":"1","oa_version":"Submitted Version","publication":"Journal of Biological Chemistry","issue":"16","day":"17","abstract":[{"lang":"eng","text":"Following its evoked release, dopamine (DA) signaling is rapidly terminated by presynaptic reuptake, mediated by the cocaine-sensitive DA transporter (DAT). DAT surface availability is dynamically regulated by endocytic trafficking, and direct protein kinase C (PKC) activation acutely diminishes DAT surface expression by accelerating DAT internalization. Previous cell line studies demonstrated that PKC-stimulated DAT endocytosis requires both Ack1 inactivation, which releases a DAT-specific endocytic brake, and the neuronal GTPase, Rit2, which binds DAT. However, it is unknown whether Rit2 is required for PKC-stimulated DAT endocytosis in DAergic terminals or whether there are region- and/or sex-dependent differences in PKC-stimulated DAT trafficking. Moreover, the mechanisms by which Rit2 controls PKC-stimulated DAT endocytosis are unknown. Here, we directly examined these important questions. Ex vivo studies revealed that PKC activation acutely decreased DAT surface expression selectively in ventral, but not dorsal, striatum. AAV-mediated, conditional Rit2 knockdown in DAergic neurons impacted baseline DAT surface:intracellular distribution in DAergic terminals from female ventral, but not dorsal, striatum. Further, Rit2 was required for PKC-stimulated DAT internalization in both male and female ventral striatum. FRET and surface pulldown studies in cell lines revealed that PKC activation drives DAT-Rit2 surface dissociation and that the DAT N terminus is required for both PKC-mediated DAT-Rit2 dissociation and DAT internalization. Finally, we found that Rit2 and Ack1 independently converge on DAT to facilitate PKC-stimulated DAT endocytosis. Together, our data provide greater insight into mechanisms that mediate PKC-regulated DAT internalization and reveal unexpected region-specific differences in PKC-stimulated DAT trafficking in bona fide DAergic terminals. "}],"date_created":"2020-05-24T22:00:59Z","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0021-9258"],"eissn":["1083-351X"]},"quality_controlled":"1","date_published":"2020-04-17T00:00:00Z","oa":1,"volume":295,"article_processing_charge":"No","month":"04","citation":{"short":"R.R. Fagan, P.J. Kearney, C.G. Sweeney, D. Luethi, F.E. Schoot Uiterkamp, K. Schicker, B.S. Alejandro, L.C. O’Connor, H.H. Sitte, H.E. Melikian, Journal of Biological Chemistry 295 (2020) 5229–5244.","ista":"Fagan RR, Kearney PJ, Sweeney CG, Luethi D, Schoot Uiterkamp FE, Schicker K, Alejandro BS, O’Connor LC, Sitte HH, Melikian HE. 2020. Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact. Journal of Biological Chemistry. 295(16), 5229–5244.","ieee":"R. R. Fagan <i>et al.</i>, “Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact,” <i>Journal of Biological Chemistry</i>, vol. 295, no. 16. ASBMB Publications, pp. 5229–5244, 2020.","mla":"Fagan, Rita R., et al. “Dopamine Transporter Trafficking and Rit2 GTPase: Mechanism of Action and in Vivo Impact.” <i>Journal of Biological Chemistry</i>, vol. 295, no. 16, ASBMB Publications, 2020, pp. 5229–44, doi:<a href=\"https://doi.org/10.1074/jbc.RA120.012628\">10.1074/jbc.RA120.012628</a>.","apa":"Fagan, R. R., Kearney, P. J., Sweeney, C. G., Luethi, D., Schoot Uiterkamp, F. E., Schicker, K., … Melikian, H. E. (2020). Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact. <i>Journal of Biological Chemistry</i>. ASBMB Publications. <a href=\"https://doi.org/10.1074/jbc.RA120.012628\">https://doi.org/10.1074/jbc.RA120.012628</a>","ama":"Fagan RR, Kearney PJ, Sweeney CG, et al. Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact. <i>Journal of Biological Chemistry</i>. 2020;295(16):5229-5244. doi:<a href=\"https://doi.org/10.1074/jbc.RA120.012628\">10.1074/jbc.RA120.012628</a>","chicago":"Fagan, Rita R., Patrick J. Kearney, Carolyn G. Sweeney, Dino Luethi, Florianne E Schoot Uiterkamp, Klaus Schicker, Brian S. Alejandro, Lauren C. O’Connor, Harald H. Sitte, and Haley E. Melikian. “Dopamine Transporter Trafficking and Rit2 GTPase: Mechanism of Action and in Vivo Impact.” <i>Journal of Biological Chemistry</i>. ASBMB Publications, 2020. <a href=\"https://doi.org/10.1074/jbc.RA120.012628\">https://doi.org/10.1074/jbc.RA120.012628</a>."},"date_updated":"2025-07-10T11:54:48Z","type":"journal_article","status":"public","publisher":"ASBMB Publications","intvolume":"       295","doi":"10.1074/jbc.RA120.012628","_id":"7880","page":"5229-5244","pmid":1,"year":"2020","isi":1,"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"doi":"10.1523/JNEUROSCI.2946-19.2020","intvolume":"        40","publisher":"Society for Neuroscience","status":"public","type":"journal_article","date_updated":"2025-03-07T08:29:32Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","isi":1,"pmid":1,"year":"2020","page":"4103-4115","_id":"7908","publication_identifier":{"eissn":["1529-2401"]},"quality_controlled":"1","language":[{"iso":"eng"}],"date_created":"2020-05-31T22:00:48Z","citation":{"ista":"Wang HY, Eguchi K, Yamashita T, Takahashi T. 2020. Frequency-dependent block of excitatory neurotransmission by isoflurane via dual presynaptic mechanisms. Journal of Neuroscience. 40(21), 4103–4115.","short":"H.Y. Wang, K. Eguchi, T. Yamashita, T. Takahashi, Journal of Neuroscience 40 (2020) 4103–4115.","apa":"Wang, H. Y., Eguchi, K., Yamashita, T., &#38; Takahashi, T. (2020). Frequency-dependent block of excitatory neurotransmission by isoflurane via dual presynaptic mechanisms. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.2946-19.2020\">https://doi.org/10.1523/JNEUROSCI.2946-19.2020</a>","mla":"Wang, Han Ying, et al. “Frequency-Dependent Block of Excitatory Neurotransmission by Isoflurane via Dual Presynaptic Mechanisms.” <i>Journal of Neuroscience</i>, vol. 40, no. 21, Society for Neuroscience, 2020, pp. 4103–15, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2946-19.2020\">10.1523/JNEUROSCI.2946-19.2020</a>.","ieee":"H. Y. Wang, K. Eguchi, T. Yamashita, and T. Takahashi, “Frequency-dependent block of excitatory neurotransmission by isoflurane via dual presynaptic mechanisms,” <i>Journal of Neuroscience</i>, vol. 40, no. 21. Society for Neuroscience, pp. 4103–4115, 2020.","ama":"Wang HY, Eguchi K, Yamashita T, Takahashi T. Frequency-dependent block of excitatory neurotransmission by isoflurane via dual presynaptic mechanisms. <i>Journal of Neuroscience</i>. 2020;40(21):4103-4115. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.2946-19.2020\">10.1523/JNEUROSCI.2946-19.2020</a>","chicago":"Wang, Han Ying, Kohgaku Eguchi, Takayuki Yamashita, and Tomoyuki Takahashi. “Frequency-Dependent Block of Excitatory Neurotransmission by Isoflurane via Dual Presynaptic Mechanisms.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2020. <a href=\"https://doi.org/10.1523/JNEUROSCI.2946-19.2020\">https://doi.org/10.1523/JNEUROSCI.2946-19.2020</a>."},"article_processing_charge":"No","volume":40,"month":"05","oa":1,"date_published":"2020-05-20T00:00:00Z","file_date_updated":"2020-07-14T12:48:05Z","has_accepted_license":"1","scopus_import":"1","publication_status":"published","abstract":[{"text":"Volatile anesthetics are widely used for surgery, but neuronal mechanisms of anesthesia remain unidentified. At the calyx of Held in brainstem slices from rats of either sex, isoflurane at clinical doses attenuated EPSCs by decreasing the release probability and the number of readily releasable vesicles. In presynaptic recordings of Ca2+ currents and exocytic capacitance changes, isoflurane attenuated exocytosis by inhibiting Ca2+ currents evoked by a short presynaptic depolarization, whereas it inhibited exocytosis evoked by a prolonged depolarization via directly blocking exocytic machinery downstream of Ca2+ influx. Since the length of presynaptic depolarization can simulate the frequency of synaptic inputs, isoflurane anesthesia is likely mediated by distinct dual mechanisms, depending on input frequencies. In simultaneous presynaptic and postsynaptic action potential recordings, isoflurane impaired the fidelity of repetitive spike transmission, more strongly at higher frequencies. Furthermore, in the cerebrum of adult mice, isoflurane inhibited monosynaptic corticocortical spike transmission, preferentially at a higher frequency. We conclude that dual presynaptic mechanisms operate for the anesthetic action of isoflurane, of which direct inhibition of exocytic machinery plays a low-pass filtering role in spike transmission at central excitatory synapses.","lang":"eng"}],"ddc":["570"],"day":"20","publication":"Journal of Neuroscience","issue":"21","oa_version":"Published Version","author":[{"full_name":"Wang, Han Ying","first_name":"Han Ying","last_name":"Wang"},{"full_name":"Eguchi, Kohgaku","last_name":"Eguchi","id":"2B7846DC-F248-11E8-B48F-1D18A9856A87","first_name":"Kohgaku","orcid":"0000-0002-6170-2546"},{"first_name":"Takayuki","full_name":"Yamashita, Takayuki","last_name":"Yamashita"},{"last_name":"Takahashi","first_name":"Tomoyuki","full_name":"Takahashi, Tomoyuki"}],"external_id":{"isi":["000535694700004"],"pmid":["32327530"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"RySh"}],"file":[{"date_created":"2020-06-02T09:12:16Z","date_updated":"2020-07-14T12:48:05Z","relation":"main_file","access_level":"open_access","checksum":"6571607ea9036154b67cc78e848a7f7d","creator":"dernst","file_id":"7912","file_name":"2020_JourNeuroscience_Wang.pdf","file_size":3817360,"content_type":"application/pdf"}],"title":"Frequency-dependent block of excitatory neurotransmission by isoflurane via dual presynaptic mechanisms"},{"ec_funded":1,"oa_version":"Published Version","publication":"Physical Review Research","abstract":[{"text":"We explore the time evolution of two impurities in a trapped one-dimensional Bose gas that follows a change of the boson-impurity interaction. We study the induced impurity-impurity interactions and their effect on the quench dynamics. In particular, we report on the size of the impurity cloud, the impurity-impurity entanglement, and the impurity-impurity correlation function. The presented numerical simulations are based upon the variational multilayer multiconfiguration time-dependent Hartree method for bosons. To analyze and quantify induced impurity-impurity correlations, we employ an effective two-body Hamiltonian with a contact interaction. We show that the effective model consistent with the mean-field attraction of two heavy impurities explains qualitatively our results for weak interactions. Our findings suggest that the quench dynamics in cold-atom systems can be a tool for studying impurity-impurity correlations.","lang":"eng"}],"ddc":["530"],"day":"11","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"publication_status":"published","scopus_import":"1","article_number":"023154 ","has_accepted_license":"1","title":"Induced correlations between impurities in a one-dimensional quenched Bose gas","file":[{"content_type":"application/pdf","file_size":1741098,"file_name":"2020_PhysRevResearch_Mistakidis.pdf","checksum":"e1c362fe094d6b246b3cd4a49722e78b","creator":"dernst","file_id":"7926","access_level":"open_access","relation":"main_file","date_updated":"2020-07-14T12:48:05Z","date_created":"2020-06-04T13:51:59Z"}],"department":[{"_id":"MiLe"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"author":[{"last_name":"Mistakidis","first_name":"S. I.","full_name":"Mistakidis, S. I."},{"first_name":"Artem","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","full_name":"Volosniev, Artem","last_name":"Volosniev","orcid":"0000-0003-0393-5525"},{"first_name":"P.","full_name":"Schmelcher, P.","last_name":"Schmelcher"}],"_id":"7919","year":"2020","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-10-21T06:02:23Z","status":"public","type":"journal_article","publisher":"American Physical Society","intvolume":"         2","doi":"10.1103/physrevresearch.2.023154","file_date_updated":"2020-07-14T12:48:05Z","date_published":"2020-05-11T00:00:00Z","oa":1,"article_processing_charge":"No","volume":2,"month":"05","citation":{"chicago":"Mistakidis, S. I., Artem Volosniev, and P. Schmelcher. “Induced Correlations between Impurities in a One-Dimensional Quenched Bose Gas.” <i>Physical Review Research</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/physrevresearch.2.023154\">https://doi.org/10.1103/physrevresearch.2.023154</a>.","ama":"Mistakidis SI, Volosniev A, Schmelcher P. Induced correlations between impurities in a one-dimensional quenched Bose gas. <i>Physical Review Research</i>. 2020;2. doi:<a href=\"https://doi.org/10.1103/physrevresearch.2.023154\">10.1103/physrevresearch.2.023154</a>","mla":"Mistakidis, S. I., et al. “Induced Correlations between Impurities in a One-Dimensional Quenched Bose Gas.” <i>Physical Review Research</i>, vol. 2, 023154, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/physrevresearch.2.023154\">10.1103/physrevresearch.2.023154</a>.","ieee":"S. I. Mistakidis, A. Volosniev, and P. Schmelcher, “Induced correlations between impurities in a one-dimensional quenched Bose gas,” <i>Physical Review Research</i>, vol. 2. American Physical Society, 2020.","apa":"Mistakidis, S. I., Volosniev, A., &#38; Schmelcher, P. (2020). Induced correlations between impurities in a one-dimensional quenched Bose gas. <i>Physical Review Research</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevresearch.2.023154\">https://doi.org/10.1103/physrevresearch.2.023154</a>","short":"S.I. Mistakidis, A. Volosniev, P. Schmelcher, Physical Review Research 2 (2020).","ista":"Mistakidis SI, Volosniev A, Schmelcher P. 2020. Induced correlations between impurities in a one-dimensional quenched Bose gas. Physical Review Research. 2, 023154."},"date_created":"2020-06-03T11:30:10Z","language":[{"iso":"eng"}],"publication_identifier":{"issn":["2643-1564"]},"quality_controlled":"1"},{"title":"The PBW theorem for affine Yangians","main_file_link":[{"url":"https://arxiv.org/abs/1804.04375","open_access":"1"}],"department":[{"_id":"TaHa"}],"external_id":{"arxiv":["1804.04375"],"isi":["000534874300003"]},"author":[{"id":"360D8648-F248-11E8-B48F-1D18A9856A87","full_name":"Yang, Yaping","first_name":"Yaping","last_name":"Yang"},{"last_name":"Zhao","first_name":"Gufang","id":"2BC2AC5E-F248-11E8-B48F-1D18A9856A87","full_name":"Zhao, Gufang"}],"ec_funded":1,"oa_version":"Preprint","publication":"Transformation Groups","project":[{"grant_number":"320593","name":"Arithmetic and physics of Higgs moduli spaces","call_identifier":"FP7","_id":"25E549F4-B435-11E9-9278-68D0E5697425"}],"abstract":[{"text":"We prove that the Yangian associated to an untwisted symmetric affine Kac–Moody Lie algebra is isomorphic to the Drinfeld double of a shuffle algebra. The latter is constructed in [YZ14] as an algebraic formalism of cohomological Hall algebras. As a consequence, we obtain the Poincare–Birkhoff–Witt (PBW) theorem for this class of affine Yangians. Another independent proof of the PBW theorem is given recently by Guay, Regelskis, and Wendlandt [GRW18].","lang":"eng"}],"day":"01","publication_status":"published","scopus_import":"1","date_published":"2020-12-01T00:00:00Z","volume":25,"article_processing_charge":"No","month":"12","oa":1,"citation":{"ieee":"Y. Yang and G. Zhao, “The PBW theorem for affine Yangians,” <i>Transformation Groups</i>, vol. 25. Springer Nature, pp. 1371–1385, 2020.","mla":"Yang, Yaping, and Gufang Zhao. “The PBW Theorem for Affine Yangians.” <i>Transformation Groups</i>, vol. 25, Springer Nature, 2020, pp. 1371–85, doi:<a href=\"https://doi.org/10.1007/s00031-020-09572-6\">10.1007/s00031-020-09572-6</a>.","apa":"Yang, Y., &#38; Zhao, G. (2020). The PBW theorem for affine Yangians. <i>Transformation Groups</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00031-020-09572-6\">https://doi.org/10.1007/s00031-020-09572-6</a>","chicago":"Yang, Yaping, and Gufang Zhao. “The PBW Theorem for Affine Yangians.” <i>Transformation Groups</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s00031-020-09572-6\">https://doi.org/10.1007/s00031-020-09572-6</a>.","ama":"Yang Y, Zhao G. The PBW theorem for affine Yangians. <i>Transformation Groups</i>. 2020;25:1371-1385. doi:<a href=\"https://doi.org/10.1007/s00031-020-09572-6\">10.1007/s00031-020-09572-6</a>","short":"Y. Yang, G. Zhao, Transformation Groups 25 (2020) 1371–1385.","ista":"Yang Y, Zhao G. 2020. The PBW theorem for affine Yangians. Transformation Groups. 25, 1371–1385."},"date_created":"2020-06-07T22:00:55Z","arxiv":1,"language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"issn":["1083-4362"],"eissn":["1531-586X"]},"page":"1371-1385","_id":"7940","year":"2020","article_type":"original","isi":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","type":"journal_article","publisher":"Springer Nature","date_updated":"2025-07-10T11:54:50Z","intvolume":"        25","doi":"10.1007/s00031-020-09572-6","acknowledgement":"Gufang Zhao is affiliated to IST Austria, Hausel group until July of 2018. Supported by the Advanced Grant Arithmetic and Physics of Higgs moduli spaces No. 320593 of the European Research Council."},{"external_id":{"isi":["000535464400005"],"arxiv":["2005.14123"]},"author":[{"first_name":"Máté","last_name":"Hartstein","full_name":"Hartstein, Máté"},{"first_name":"Yu Te","full_name":"Hsu, Yu Te","last_name":"Hsu"},{"orcid":"0000-0001-9760-3147","full_name":"Modic, Kimberly A","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425","first_name":"Kimberly A","last_name":"Modic"},{"full_name":"Porras, Juan","last_name":"Porras","first_name":"Juan"},{"first_name":"Toshinao","full_name":"Loew, Toshinao","last_name":"Loew"},{"full_name":"Tacon, Matthieu Le","first_name":"Matthieu Le","last_name":"Tacon"},{"full_name":"Zuo, Huakun","first_name":"Huakun","last_name":"Zuo"},{"full_name":"Wang, Jinhua","first_name":"Jinhua","last_name":"Wang"},{"last_name":"Zhu","full_name":"Zhu, Zengwei","first_name":"Zengwei"},{"full_name":"Chan, Mun K.","last_name":"Chan","first_name":"Mun K."},{"first_name":"Ross D.","last_name":"Mcdonald","full_name":"Mcdonald, Ross D."},{"last_name":"Lonzarich","full_name":"Lonzarich, Gilbert G.","first_name":"Gilbert G."},{"first_name":"Bernhard","last_name":"Keimer","full_name":"Keimer, Bernhard"},{"full_name":"Sebastian, Suchitra E.","first_name":"Suchitra E.","last_name":"Sebastian"},{"full_name":"Harrison, Neil","first_name":"Neil","last_name":"Harrison"}],"title":"Hard antinodal gap revealed by quantum oscillations in the pseudogap regime of underdoped high-Tc superconductors","main_file_link":[{"url":"https://arxiv.org/abs/2005.14123","open_access":"1"}],"department":[{"_id":"KiMo"}],"publication_status":"published","scopus_import":"1","related_material":{"record":[{"status":"public","relation":"research_data","id":"9708"}]},"oa_version":"Preprint","publication":"Nature Physics","abstract":[{"text":"An understanding of the missing antinodal electronic excitations in the pseudogap state is essential for uncovering the physics of the underdoped cuprate high-temperature superconductors1,2,3,4,5,6. The majority of high-temperature experiments performed thus far, however, have been unable to discern whether the antinodal states are rendered unobservable due to their damping or whether they vanish due to their gapping7,8,9,10,11,12,13,14,15,16,17,18. Here, we distinguish between these two scenarios by using quantum oscillations to examine whether the small Fermi surface pocket, found to occupy only 2% of the Brillouin zone in the underdoped cuprates19,20,21,22,23,24, exists in isolation against a majority of completely gapped density of states spanning the antinodes, or whether it is thermodynamically coupled to a background of ungapped antinodal states. We find that quantum oscillations associated with the small Fermi surface pocket exhibit a signature sawtooth waveform characteristic of an isolated two-dimensional Fermi surface pocket25,26,27,28,29,30,31,32. This finding reveals that the antinodal states are destroyed by a hard gap that extends over the majority of the Brillouin zone, placing strong constraints on a drastic underlying origin of quasiparticle disappearance over almost the entire Brillouin zone in the pseudogap regime7,8,9,10,11,12,13,14,15,16,17,18.","lang":"eng"}],"day":"01","arxiv":1,"date_created":"2020-06-07T22:00:56Z","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"quality_controlled":"1","date_published":"2020-08-01T00:00:00Z","oa":1,"volume":16,"month":"08","article_processing_charge":"No","citation":{"ama":"Hartstein M, Hsu YT, Modic KA, et al. Hard antinodal gap revealed by quantum oscillations in the pseudogap regime of underdoped high-Tc superconductors. <i>Nature Physics</i>. 2020;16:841-847. doi:<a href=\"https://doi.org/10.1038/s41567-020-0910-0\">10.1038/s41567-020-0910-0</a>","chicago":"Hartstein, Máté, Yu Te Hsu, Kimberly A Modic, Juan Porras, Toshinao Loew, Matthieu Le Tacon, Huakun Zuo, et al. “Hard Antinodal Gap Revealed by Quantum Oscillations in the Pseudogap Regime of Underdoped High-Tc Superconductors.” <i>Nature Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41567-020-0910-0\">https://doi.org/10.1038/s41567-020-0910-0</a>.","mla":"Hartstein, Máté, et al. “Hard Antinodal Gap Revealed by Quantum Oscillations in the Pseudogap Regime of Underdoped High-Tc Superconductors.” <i>Nature Physics</i>, vol. 16, Springer Nature, 2020, pp. 841–47, doi:<a href=\"https://doi.org/10.1038/s41567-020-0910-0\">10.1038/s41567-020-0910-0</a>.","ieee":"M. Hartstein <i>et al.</i>, “Hard antinodal gap revealed by quantum oscillations in the pseudogap regime of underdoped high-Tc superconductors,” <i>Nature Physics</i>, vol. 16. Springer Nature, pp. 841–847, 2020.","apa":"Hartstein, M., Hsu, Y. T., Modic, K. A., Porras, J., Loew, T., Tacon, M. L., … Harrison, N. (2020). Hard antinodal gap revealed by quantum oscillations in the pseudogap regime of underdoped high-Tc superconductors. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-020-0910-0\">https://doi.org/10.1038/s41567-020-0910-0</a>","short":"M. Hartstein, Y.T. Hsu, K.A. Modic, J. Porras, T. Loew, M.L. Tacon, H. Zuo, J. Wang, Z. Zhu, M.K. Chan, R.D. Mcdonald, G.G. Lonzarich, B. Keimer, S.E. Sebastian, N. Harrison, Nature Physics 16 (2020) 841–847.","ista":"Hartstein M, Hsu YT, Modic KA, Porras J, Loew T, Tacon ML, Zuo H, Wang J, Zhu Z, Chan MK, Mcdonald RD, Lonzarich GG, Keimer B, Sebastian SE, Harrison N. 2020. Hard antinodal gap revealed by quantum oscillations in the pseudogap regime of underdoped high-Tc superconductors. Nature Physics. 16, 841–847."},"date_updated":"2025-07-10T11:54:52Z","type":"journal_article","status":"public","publisher":"Springer Nature","intvolume":"        16","doi":"10.1038/s41567-020-0910-0","acknowledgement":"M.H., Y.-T.H. and S.E.S. acknowledge support from the Royal Society, the Winton Programme for the Physics of Sustainability, EPSRC (studentship, grant no. EP/P024947/1 and EPSRC Strategic Equipment grant no. EP/M000524/1) and the European Research Council (grant no. 772891). S.E.S. acknowledges support from the Leverhulme Trust by way of the award of a Philip Leverhulme Prize. H.Z., J.W. and Z.Z. acknowledge support from the National Key Research and Development Program of China (grant no. 2016YFA0401704). A portion of this work was performed at the National High Magnetic Field Laboratory, which is supported by the National Science Foundation Cooperative Agreement no. DMR-1644779, the state of Florida and the US Department of Energy. Work performed by M.K.C., R.D.M. and N.H. was supported by the US DOE BES ‘Science of 100 T’ programme.","_id":"7942","page":"841-847","year":"2020","isi":1,"article_type":"letter_note","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"date_created":"2020-06-08T10:10:28Z","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"issn":["0022-0957"],"eissn":["1460-2431"]},"date_published":"2020-07-25T00:00:00Z","volume":71,"month":"07","article_processing_charge":"No","oa":1,"citation":{"short":"A. Maghiaoui, E. Bouguyon, C. Cuesta, F. Perrine-Walker, C. Alcon, G. Krouk, E. Benková, P. Nacry, A. Gojon, L. Bach, Journal of Experimental Botany 71 (2020) 4480–4494.","ista":"Maghiaoui A, Bouguyon E, Cuesta C, Perrine-Walker F, Alcon C, Krouk G, Benková E, Nacry P, Gojon A, Bach L. 2020. The Arabidopsis NRT1.1 transceptor coordinately controls auxin biosynthesis and transport to regulate root branching in response to nitrate. Journal of Experimental Botany. 71(15), 4480–4494.","ama":"Maghiaoui A, Bouguyon E, Cuesta C, et al. The Arabidopsis NRT1.1 transceptor coordinately controls auxin biosynthesis and transport to regulate root branching in response to nitrate. <i>Journal of Experimental Botany</i>. 2020;71(15):4480-4494. doi:<a href=\"https://doi.org/10.1093/jxb/eraa242\">10.1093/jxb/eraa242</a>","chicago":"Maghiaoui, A, E Bouguyon, Candela Cuesta, F Perrine-Walker, C Alcon, G Krouk, Eva Benková, P Nacry, A Gojon, and L Bach. “The Arabidopsis NRT1.1 Transceptor Coordinately Controls Auxin Biosynthesis and Transport to Regulate Root Branching in Response to Nitrate.” <i>Journal of Experimental Botany</i>. Oxford University Press, 2020. <a href=\"https://doi.org/10.1093/jxb/eraa242\">https://doi.org/10.1093/jxb/eraa242</a>.","mla":"Maghiaoui, A., et al. “The Arabidopsis NRT1.1 Transceptor Coordinately Controls Auxin Biosynthesis and Transport to Regulate Root Branching in Response to Nitrate.” <i>Journal of Experimental Botany</i>, vol. 71, no. 15, Oxford University Press, 2020, pp. 4480–94, doi:<a href=\"https://doi.org/10.1093/jxb/eraa242\">10.1093/jxb/eraa242</a>.","ieee":"A. Maghiaoui <i>et al.</i>, “The Arabidopsis NRT1.1 transceptor coordinately controls auxin biosynthesis and transport to regulate root branching in response to nitrate,” <i>Journal of Experimental Botany</i>, vol. 71, no. 15. Oxford University Press, pp. 4480–4494, 2020.","apa":"Maghiaoui, A., Bouguyon, E., Cuesta, C., Perrine-Walker, F., Alcon, C., Krouk, G., … Bach, L. (2020). The Arabidopsis NRT1.1 transceptor coordinately controls auxin biosynthesis and transport to regulate root branching in response to nitrate. <i>Journal of Experimental Botany</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/jxb/eraa242\">https://doi.org/10.1093/jxb/eraa242</a>"},"status":"public","type":"journal_article","publisher":"Oxford University Press","date_updated":"2024-10-21T06:02:27Z","intvolume":"        71","doi":"10.1093/jxb/eraa242","page":"4480-4494","_id":"7948","pmid":1,"year":"2020","article_type":"original","isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000553127600013"],"pmid":["32428238"]},"author":[{"first_name":"A","full_name":"Maghiaoui, A","last_name":"Maghiaoui"},{"last_name":"Bouguyon","first_name":"E","full_name":"Bouguyon, E"},{"orcid":"0000-0003-1923-2410","first_name":"Candela","last_name":"Cuesta","id":"33A3C818-F248-11E8-B48F-1D18A9856A87","full_name":"Cuesta, Candela"},{"first_name":"F","last_name":"Perrine-Walker","full_name":"Perrine-Walker, F"},{"last_name":"Alcon","first_name":"C","full_name":"Alcon, C"},{"full_name":"Krouk, G","last_name":"Krouk","first_name":"G"},{"full_name":"Benková, Eva","last_name":"Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","orcid":"0000-0002-8510-9739"},{"first_name":"P","full_name":"Nacry, P","last_name":"Nacry"},{"last_name":"Gojon","first_name":"A","full_name":"Gojon, A"},{"last_name":"Bach","full_name":"Bach, L","first_name":"L"}],"title":"The Arabidopsis NRT1.1 transceptor coordinately controls auxin biosynthesis and transport to regulate root branching in response to nitrate","main_file_link":[{"url":"https://hal.inrae.fr/hal-02619371","open_access":"1"}],"department":[{"_id":"EvBe"}],"publication_status":"published","scopus_import":"1","oa_version":"Submitted Version","issue":"15","publication":"Journal of Experimental Botany","abstract":[{"text":"In agricultural systems, nitrate is the main source of nitrogen available for plants. Besides its role as a nutrient, nitrate has been shown to act as a signal molecule for plant growth, development and stress responses. In Arabidopsis, the NRT1.1 nitrate transceptor represses lateral root (LR) development at low nitrate availability by promoting auxin basipetal transport out of the LR primordia (LRPs). In addition, our present study shows that NRT1.1 acts as a negative regulator of the TAR2 auxin biosynthetic gene expression in the root stele. This is expected to repress local auxin biosynthesis and thus to reduce acropetal auxin supply to the LRPs. Moreover, NRT1.1 also negatively affects expression of the LAX3 auxin influx carrier, thus preventing cell wall remodeling required for overlying tissues separation during LRP emergence. Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Altogether, our results indicate that the NRT1.1 transceptor coordinately controls several crucial auxin-associated processes required for LRP development, and as a consequence that NRT1.1 plays a much more integrated role than previously anticipated in regulating the nitrate response of root system architecture.","lang":"eng"}],"day":"25"},{"oa_version":"Published Version","publication":"Molecular & Cellular Proteomics","issue":"8","abstract":[{"lang":"eng","text":"Peptides derived from non-functional precursors play important roles in various developmental processes, but also in (a)biotic stress signaling. Our (phospho)proteome-wide analyses of C-terminally encoded peptide 5 (CEP5)-mediated changes revealed an impact on abiotic stress-related processes. Drought has a dramatic impact on plant growth, development and reproduction, and the plant hormone auxin plays a role in drought responses. Our genetic, physiological, biochemical and pharmacological results demonstrated that CEP5-mediated signaling is relevant for osmotic and drought stress tolerance in Arabidopsis, and that CEP5 specifically counteracts auxin effects. Specifically, we found that CEP5 signaling stabilizes AUX/IAA transcriptional repressors, suggesting the existence of a novel peptide-dependent control mechanism that tunes auxin signaling. These observations align with the recently described role of AUX/IAAs in stress tolerance and provide a novel role for CEP5 in osmotic and drought stress tolerance."}],"day":"01","ddc":["580"],"publication_status":"published","scopus_import":"1","has_accepted_license":"1","title":"The CEP5 peptide promotes abiotic stress tolerance, as revealed by quantitative proteomics, and attenuates the AUX/IAA equilibrium in Arabidopsis","file":[{"file_name":"2020_MCP_Smith.pdf","success":1,"file_id":"9373","checksum":"3f3f37b4a1ba2cfd270fc7733dd89680","creator":"kschuh","date_created":"2021-05-05T10:10:14Z","access_level":"open_access","relation":"main_file","date_updated":"2021-05-05T10:10:14Z","content_type":"application/pdf","file_size":1632311}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"JiFr"}],"external_id":{"isi":["000561114000001"],"pmid":["32404488"]},"author":[{"full_name":"Smith, S","first_name":"S","last_name":"Smith"},{"last_name":"Zhu","first_name":"S","full_name":"Zhu, S"},{"first_name":"L","last_name":"Joos","full_name":"Joos, L"},{"full_name":"Roberts, I","first_name":"I","last_name":"Roberts"},{"last_name":"Nikonorova","full_name":"Nikonorova, N","first_name":"N"},{"last_name":"Vu","full_name":"Vu, LD","first_name":"LD"},{"full_name":"Stes, E","last_name":"Stes","first_name":"E"},{"first_name":"H","last_name":"Cho","full_name":"Cho, H"},{"full_name":"Larrieu, A","last_name":"Larrieu","first_name":"A"},{"last_name":"Xuan","full_name":"Xuan, W","first_name":"W"},{"full_name":"Goodall, B","last_name":"Goodall","first_name":"B"},{"full_name":"van de Cotte, B","first_name":"B","last_name":"van de Cotte"},{"full_name":"Waite, JM","first_name":"JM","last_name":"Waite"},{"last_name":"Rigal","full_name":"Rigal, A","first_name":"A"},{"last_name":"R Harborough","first_name":"SR","full_name":"R Harborough, SR"},{"first_name":"G","last_name":"Persiau","full_name":"Persiau, G"},{"first_name":"S","full_name":"Vanneste, S","last_name":"Vanneste"},{"full_name":"Kirschner, GK","last_name":"Kirschner","first_name":"GK"},{"first_name":"E","last_name":"Vandermarliere","full_name":"Vandermarliere, E"},{"first_name":"L","full_name":"Martens, L","last_name":"Martens"},{"full_name":"Stahl, Y","first_name":"Y","last_name":"Stahl"},{"full_name":"Audenaert, D","last_name":"Audenaert","first_name":"D"},{"orcid":"0000-0002-8302-7596","first_name":"Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří"},{"last_name":"Felix","first_name":"G","full_name":"Felix, G"},{"full_name":"Simon, R","first_name":"R","last_name":"Simon"},{"full_name":"Bennett, M","first_name":"M","last_name":"Bennett"},{"full_name":"Bishopp, A","last_name":"Bishopp","first_name":"A"},{"first_name":"G","full_name":"De Jaeger, G","last_name":"De Jaeger"},{"first_name":"K","full_name":"Ljung, K","last_name":"Ljung"},{"first_name":"S","full_name":"Kepinski, S","last_name":"Kepinski"},{"last_name":"Robert","full_name":"Robert, S","first_name":"S"},{"full_name":"Nemhauser, J","last_name":"Nemhauser","first_name":"J"},{"full_name":"Hwang, I","first_name":"I","last_name":"Hwang"},{"last_name":"Gevaert","full_name":"Gevaert, K","first_name":"K"},{"first_name":"T","full_name":"Beeckman, T","last_name":"Beeckman"},{"full_name":"De Smet, I","first_name":"I","last_name":"De Smet"}],"_id":"7949","page":"1248-1262","pmid":1,"year":"2020","isi":1,"article_type":"original","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-05T12:17:46Z","publisher":"American Society for Biochemistry and Molecular Biology","type":"journal_article","status":"public","intvolume":"        19","acknowledgement":"We thank Maria Njo, Sarah De Cokere, Marieke Mispelaere and Darren Wells, for practical assistance, Daniël Van Damme for assistance with image analysis, Marnik Vuylsteke for advice on statistics, Catherine Perrot-Rechenmann for useful discussions, Steffen Lau for critical reading oft he manuscript, and Philip Benfey, Gerd Jürgens, Philippe Nacry, Frederik Börnke, and Frans Tax for sharing materials.","doi":"10.1074/mcp.ra119.001826","file_date_updated":"2021-05-05T10:10:14Z","date_published":"2020-08-01T00:00:00Z","oa":1,"article_processing_charge":"No","volume":19,"month":"08","citation":{"chicago":"Smith, S, S Zhu, L Joos, I Roberts, N Nikonorova, LD Vu, E Stes, et al. “The CEP5 Peptide Promotes Abiotic Stress Tolerance, as Revealed by Quantitative Proteomics, and Attenuates the AUX/IAA Equilibrium in Arabidopsis.” <i>Molecular &#38; Cellular Proteomics</i>. American Society for Biochemistry and Molecular Biology, 2020. <a href=\"https://doi.org/10.1074/mcp.ra119.001826\">https://doi.org/10.1074/mcp.ra119.001826</a>.","ama":"Smith S, Zhu S, Joos L, et al. The CEP5 peptide promotes abiotic stress tolerance, as revealed by quantitative proteomics, and attenuates the AUX/IAA equilibrium in Arabidopsis. <i>Molecular &#38; Cellular Proteomics</i>. 2020;19(8):1248-1262. doi:<a href=\"https://doi.org/10.1074/mcp.ra119.001826\">10.1074/mcp.ra119.001826</a>","mla":"Smith, S., et al. “The CEP5 Peptide Promotes Abiotic Stress Tolerance, as Revealed by Quantitative Proteomics, and Attenuates the AUX/IAA Equilibrium in Arabidopsis.” <i>Molecular &#38; Cellular Proteomics</i>, vol. 19, no. 8, American Society for Biochemistry and Molecular Biology, 2020, pp. 1248–62, doi:<a href=\"https://doi.org/10.1074/mcp.ra119.001826\">10.1074/mcp.ra119.001826</a>.","ieee":"S. Smith <i>et al.</i>, “The CEP5 peptide promotes abiotic stress tolerance, as revealed by quantitative proteomics, and attenuates the AUX/IAA equilibrium in Arabidopsis,” <i>Molecular &#38; Cellular Proteomics</i>, vol. 19, no. 8. American Society for Biochemistry and Molecular Biology, pp. 1248–1262, 2020.","apa":"Smith, S., Zhu, S., Joos, L., Roberts, I., Nikonorova, N., Vu, L., … De Smet, I. (2020). The CEP5 peptide promotes abiotic stress tolerance, as revealed by quantitative proteomics, and attenuates the AUX/IAA equilibrium in Arabidopsis. <i>Molecular &#38; Cellular Proteomics</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/mcp.ra119.001826\">https://doi.org/10.1074/mcp.ra119.001826</a>","short":"S. Smith, S. Zhu, L. Joos, I. Roberts, N. Nikonorova, L. Vu, E. Stes, H. Cho, A. Larrieu, W. Xuan, B. Goodall, B. van de Cotte, J. Waite, A. Rigal, S. R Harborough, G. Persiau, S. Vanneste, G. Kirschner, E. Vandermarliere, L. Martens, Y. Stahl, D. Audenaert, J. Friml, G. Felix, R. Simon, M. Bennett, A. Bishopp, G. De Jaeger, K. Ljung, S. Kepinski, S. Robert, J. Nemhauser, I. Hwang, K. Gevaert, T. Beeckman, I. De Smet, Molecular &#38; Cellular Proteomics 19 (2020) 1248–1262.","ista":"Smith S, Zhu S, Joos L, Roberts I, Nikonorova N, Vu L, Stes E, Cho H, Larrieu A, Xuan W, Goodall B, van de Cotte B, Waite J, Rigal A, R Harborough S, Persiau G, Vanneste S, Kirschner G, Vandermarliere E, Martens L, Stahl Y, Audenaert D, Friml J, Felix G, Simon R, Bennett M, Bishopp A, De Jaeger G, Ljung K, Kepinski S, Robert S, Nemhauser J, Hwang I, Gevaert K, Beeckman T, De Smet I. 2020. The CEP5 peptide promotes abiotic stress tolerance, as revealed by quantitative proteomics, and attenuates the AUX/IAA equilibrium in Arabidopsis. Molecular &#38; Cellular Proteomics. 19(8), 1248–1262."},"date_created":"2020-06-08T10:10:53Z","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"eissn":["1535-9484"]}},{"conference":{"end_date":"2020-06-26","name":"SoCG: Symposium on Computational Geometry","start_date":"2020-06-22","location":"Zürich, Switzerland"},"date_created":"2020-06-09T07:24:11Z","publication_identifier":{"issn":["1868-8969"],"isbn":["978-3-95977-143-6"]},"quality_controlled":"1","language":[{"iso":"eng"}],"date_published":"2020-06-01T00:00:00Z","file_date_updated":"2020-07-14T12:48:06Z","citation":{"short":"J.-D. Boissonnat, M. Wintraecken, in:, 36th International Symposium on Computational Geometry, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020.","ista":"Boissonnat J-D, Wintraecken M. 2020. The topological correctness of PL-approximations of isomanifolds. 36th International Symposium on Computational Geometry. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 164, 20:1-20:18.","chicago":"Boissonnat, Jean-Daniel, and Mathijs Wintraecken. “The Topological Correctness of PL-Approximations of Isomanifolds.” In <i>36th International Symposium on Computational Geometry</i>, Vol. 164. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2020.20\">https://doi.org/10.4230/LIPIcs.SoCG.2020.20</a>.","ama":"Boissonnat J-D, Wintraecken M. The topological correctness of PL-approximations of isomanifolds. In: <i>36th International Symposium on Computational Geometry</i>. Vol 164. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2020. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2020.20\">10.4230/LIPIcs.SoCG.2020.20</a>","ieee":"J.-D. Boissonnat and M. Wintraecken, “The topological correctness of PL-approximations of isomanifolds,” in <i>36th International Symposium on Computational Geometry</i>, Zürich, Switzerland, 2020, vol. 164.","mla":"Boissonnat, Jean-Daniel, and Mathijs Wintraecken. “The Topological Correctness of PL-Approximations of Isomanifolds.” <i>36th International Symposium on Computational Geometry</i>, vol. 164, 20:1-20:18, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2020.20\">10.4230/LIPIcs.SoCG.2020.20</a>.","apa":"Boissonnat, J.-D., &#38; Wintraecken, M. (2020). The topological correctness of PL-approximations of isomanifolds. In <i>36th International Symposium on Computational Geometry</i> (Vol. 164). Zürich, Switzerland: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2020.20\">https://doi.org/10.4230/LIPIcs.SoCG.2020.20</a>"},"article_processing_charge":"No","month":"06","volume":164,"oa":1,"intvolume":"       164","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","status":"public","type":"conference","date_updated":"2025-04-22T13:45:17Z","doi":"10.4230/LIPIcs.SoCG.2020.20","year":"2020","_id":"7952","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Boissonnat, Jean-Daniel","last_name":"Boissonnat","first_name":"Jean-Daniel"},{"id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","first_name":"Mathijs","full_name":"Wintraecken, Mathijs","last_name":"Wintraecken","orcid":"0000-0002-7472-2220"}],"title":"The topological correctness of PL-approximations of isomanifolds","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"HeEd"}],"file":[{"file_name":"2020_LIPIcsSoCG_Boissonnat.pdf","creator":"dernst","checksum":"38cbfa4f5d484d267a35d44d210df044","file_id":"7969","relation":"main_file","date_updated":"2020-07-14T12:48:06Z","access_level":"open_access","date_created":"2020-06-17T10:13:34Z","content_type":"application/pdf","file_size":1009739}],"scopus_import":"1","corr_author":"1","publication_status":"published","related_material":{"record":[{"relation":"later_version","status":"public","id":"9649"}]},"has_accepted_license":"1","article_number":"20:1-20:18","alternative_title":["LIPIcs"],"oa_version":"Published Version","ec_funded":1,"project":[{"call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"}],"ddc":["510"],"day":"01","abstract":[{"lang":"eng","text":"Isomanifolds are the generalization of isosurfaces to arbitrary dimension and codimension, i.e. manifolds defined as the zero set of some multivariate vector-valued smooth function f: ℝ^d → ℝ^(d-n). A natural (and efficient) way to approximate an isomanifold is to consider its Piecewise-Linear (PL) approximation based on a triangulation 𝒯 of the ambient space ℝ^d. In this paper, we give conditions under which the PL-approximation of an isomanifold is topologically equivalent to the isomanifold. The conditions are easy to satisfy in the sense that they can always be met by taking a sufficiently fine triangulation 𝒯. This contrasts with previous results on the triangulation of manifolds where, in arbitrary dimensions, delicate perturbations are needed to guarantee topological correctness, which leads to strong limitations in practice. We further give a bound on the Fréchet distance between the original isomanifold and its PL-approximation. Finally we show analogous results for the PL-approximation of an isomanifold with boundary. "}],"publication":"36th International Symposium on Computational Geometry"},{"publication_identifier":{"isbn":["9781450371049"]},"quality_controlled":"1","language":[{"iso":"eng"}],"conference":{"location":"Saarbrücken, Germany","start_date":"2020-07-08","end_date":"2020-07-11","name":"LICS: Logic in Computer Science"},"arxiv":1,"date_created":"2020-06-14T22:00:48Z","citation":{"chicago":"Ashok, Pranav, Krishnendu Chatterjee, Jan Kretinsky, Maximilian Weininger, and Tobias Winkler. “Approximating Values of Generalized-Reachability Stochastic Games.” In <i>Proceedings of the 35th Annual ACM/IEEE Symposium on Logic in Computer Science </i>, 102–15. Association for Computing Machinery, 2020. <a href=\"https://doi.org/10.1145/3373718.3394761\">https://doi.org/10.1145/3373718.3394761</a>.","ama":"Ashok P, Chatterjee K, Kretinsky J, Weininger M, Winkler T. Approximating values of generalized-reachability stochastic games. In: <i>Proceedings of the 35th Annual ACM/IEEE Symposium on Logic in Computer Science </i>. Association for Computing Machinery; 2020:102-115. doi:<a href=\"https://doi.org/10.1145/3373718.3394761\">10.1145/3373718.3394761</a>","apa":"Ashok, P., Chatterjee, K., Kretinsky, J., Weininger, M., &#38; Winkler, T. (2020). Approximating values of generalized-reachability stochastic games. In <i>Proceedings of the 35th Annual ACM/IEEE Symposium on Logic in Computer Science </i> (pp. 102–115). Saarbrücken, Germany: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3373718.3394761\">https://doi.org/10.1145/3373718.3394761</a>","mla":"Ashok, Pranav, et al. “Approximating Values of Generalized-Reachability Stochastic Games.” <i>Proceedings of the 35th Annual ACM/IEEE Symposium on Logic in Computer Science </i>, Association for Computing Machinery, 2020, pp. 102–15, doi:<a href=\"https://doi.org/10.1145/3373718.3394761\">10.1145/3373718.3394761</a>.","ieee":"P. Ashok, K. Chatterjee, J. Kretinsky, M. Weininger, and T. Winkler, “Approximating values of generalized-reachability stochastic games,” in <i>Proceedings of the 35th Annual ACM/IEEE Symposium on Logic in Computer Science </i>, Saarbrücken, Germany, 2020, pp. 102–115.","ista":"Ashok P, Chatterjee K, Kretinsky J, Weininger M, Winkler T. 2020. Approximating values of generalized-reachability stochastic games. Proceedings of the 35th Annual ACM/IEEE Symposium on Logic in Computer Science . LICS: Logic in Computer Science, 102–115.","short":"P. Ashok, K. Chatterjee, J. Kretinsky, M. Weininger, T. Winkler, in:, Proceedings of the 35th Annual ACM/IEEE Symposium on Logic in Computer Science , Association for Computing Machinery, 2020, pp. 102–115."},"oa":1,"article_processing_charge":"No","month":"07","date_published":"2020-07-08T00:00:00Z","file_date_updated":"2020-11-25T09:38:14Z","doi":"10.1145/3373718.3394761","acknowledgement":"Pranav Ashok, Jan Křetínský and Maximilian Weininger were funded in part by TUM IGSSE Grant 10.06 (PARSEC) and the German Research Foundation (DFG) project KR 4890/2-1\r\n“Statistical Unbounded Verification”. Krishnendu Chatterjee was supported by the ERC CoG 863818 (ForM-SMArt) and Vienna Science and Technology Fund (WWTF) Project ICT15-\r\n003. Tobias Winkler was supported by the RTG 2236 UnRAVe.","date_updated":"2025-07-10T11:54:53Z","publisher":"Association for Computing Machinery","type":"conference","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","isi":1,"year":"2020","_id":"7955","page":"102-115","author":[{"first_name":"Pranav","last_name":"Ashok","full_name":"Ashok, Pranav"},{"orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","first_name":"Krishnendu"},{"last_name":"Kretinsky","first_name":"Jan","full_name":"Kretinsky, Jan"},{"last_name":"Weininger","full_name":"Weininger, Maximilian","first_name":"Maximilian"},{"first_name":"Tobias","full_name":"Winkler, Tobias","last_name":"Winkler"}],"external_id":{"isi":["000665014900010"],"arxiv":["1908.05106"]},"department":[{"_id":"KrCh"}],"file":[{"content_type":"application/pdf","file_size":1001395,"checksum":"d0d0288fe991dd16cf5f02598b794240","creator":"dernst","file_id":"8804","date_created":"2020-11-25T09:38:14Z","relation":"main_file","date_updated":"2020-11-25T09:38:14Z","access_level":"open_access","file_name":"2020_LICS_Ashok.pdf","success":1}],"title":"Approximating values of generalized-reachability stochastic games","has_accepted_license":"1","scopus_import":"1","publication_status":"published","day":"08","ddc":["000"],"abstract":[{"lang":"eng","text":"Simple stochastic games are turn-based 2½-player games with a reachability objective. The basic question asks whether one player can ensure reaching a given target with at least a given probability. A natural extension is games with a conjunction of such conditions as objective. Despite a plethora of recent results on the analysis of systems with multiple objectives, the decidability of this basic problem remains open. In this paper, we present an algorithm approximating the Pareto frontier of the achievable values to a given precision. Moreover, it is an anytime algorithm, meaning it can be stopped at any time returning the current approximation and its error bound."}],"project":[{"grant_number":"863818","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020","name":"Formal Methods for Stochastic Models: Algorithms and Applications"},{"name":"Efficient Algorithms for Computer Aided Verification","_id":"25892FC0-B435-11E9-9278-68D0E5697425","grant_number":"ICT15-003"}],"publication":"Proceedings of the 35th Annual ACM/IEEE Symposium on Logic in Computer Science ","oa_version":"Published Version","ec_funded":1},{"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1907.00885"}],"department":[{"_id":"UlWa"}],"title":"Intersection patterns of planar sets","author":[{"full_name":"Kalai, Gil","last_name":"Kalai","first_name":"Gil"},{"orcid":"0000-0002-3975-1683","full_name":"Patakova, Zuzana","first_name":"Zuzana","id":"48B57058-F248-11E8-B48F-1D18A9856A87","last_name":"Patakova"}],"external_id":{"isi":["000537329400001"],"arxiv":["1907.00885"]},"publication":"Discrete and Computational Geometry","day":"01","abstract":[{"lang":"eng","text":"Let A={A1,…,An} be a family of sets in the plane. For 0≤i<n, denote by fi the number of subsets σ of {1,…,n} of cardinality i+1 that satisfy ⋂i∈σAi≠∅. Let k≥2 be an integer. We prove that if each k-wise and (k+1)-wise intersection of sets from A is empty, or a single point, or both open and path-connected, then fk+1=0 implies fk≤cfk−1 for some positive constant c depending only on k. Similarly, let b≥2, k>2b be integers. We prove that if each k-wise or (k+1)-wise intersection of sets from A has at most b path-connected components, which all are open, then fk+1=0 implies fk≤cfk−1 for some positive constant c depending only on b and k. These results also extend to two-dimensional compact surfaces."}],"oa_version":"Preprint","publication_status":"published","scopus_import":"1","oa":1,"month":"09","volume":64,"article_processing_charge":"No","citation":{"ieee":"G. Kalai and Z. Patakova, “Intersection patterns of planar sets,” <i>Discrete and Computational Geometry</i>, vol. 64. Springer Nature, pp. 304–323, 2020.","mla":"Kalai, Gil, and Zuzana Patakova. “Intersection Patterns of Planar Sets.” <i>Discrete and Computational Geometry</i>, vol. 64, Springer Nature, 2020, pp. 304–23, doi:<a href=\"https://doi.org/10.1007/s00454-020-00205-z\">10.1007/s00454-020-00205-z</a>.","apa":"Kalai, G., &#38; Patakova, Z. (2020). Intersection patterns of planar sets. <i>Discrete and Computational Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00454-020-00205-z\">https://doi.org/10.1007/s00454-020-00205-z</a>","chicago":"Kalai, Gil, and Zuzana Patakova. “Intersection Patterns of Planar Sets.” <i>Discrete and Computational Geometry</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s00454-020-00205-z\">https://doi.org/10.1007/s00454-020-00205-z</a>.","ama":"Kalai G, Patakova Z. Intersection patterns of planar sets. <i>Discrete and Computational Geometry</i>. 2020;64:304-323. doi:<a href=\"https://doi.org/10.1007/s00454-020-00205-z\">10.1007/s00454-020-00205-z</a>","short":"G. Kalai, Z. Patakova, Discrete and Computational Geometry 64 (2020) 304–323.","ista":"Kalai G, Patakova Z. 2020. Intersection patterns of planar sets. Discrete and Computational Geometry. 64, 304–323."},"date_published":"2020-09-01T00:00:00Z","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"eissn":["14320444"],"issn":["01795376"]},"arxiv":1,"date_created":"2020-06-14T22:00:50Z","isi":1,"article_type":"original","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"7960","page":"304-323","year":"2020","doi":"10.1007/s00454-020-00205-z","acknowledgement":"We are very grateful to Pavel Paták for many helpful discussions and remarks. We also thank the referees for helpful comments, which greatly improved the presentation.\r\nThe project was supported by ERC Advanced Grant 320924. GK was also partially supported by NSF grant DMS1300120. The research stay of ZP at IST Austria is funded by the project CZ.02.2.69/0.0/0.0/17_050/0008466 Improvement of internationalization in the field of research and development at Charles University, through the support of quality projects MSCA-IF.","date_updated":"2023-08-21T08:26:34Z","type":"journal_article","status":"public","publisher":"Springer Nature","intvolume":"        64"}]