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Our primary contributions are a strategy for dynamically deforming regular grids over the course of a simulation and a method for efficiently utilizing these deforming grids for liquid simulation. Prior work has shown that unstructured grids are very effective for adaptive fluid simulations. However, unstructured grids often lead to complicated implementations and a poor cache hit rate due to inconsistent memory access. Regular grids, on the other hand, provide a fast, fixed memory access pattern and straightforward implementation. Our method combines the advantages of both: we leverage the simplicity of regular grids while still achieving practical and controllable spatial adaptivity. We demonstrate that our method enables adaptive simulations that are fast, flexible, and robust to null-space issues. At the same time, our method is simple to implement and takes advantage of existing highly-tuned algorithms."}],"article_processing_charge":"No","date_created":"2018-12-16T22:59:21Z","article_type":"original","citation":{"ieee":"I. Hikaru, C. Wojtan, N. Thuerey, T. Igarashi, and R. Ando, “Simulating liquids on dynamically warping grids,” IEEE Transactions on Visualization and Computer Graphics, vol. 26, no. 6. IEEE, pp. 2288–2302, 2020.","ista":"Hikaru I, Wojtan C, Thuerey N, Igarashi T, Ando R. 2020. Simulating liquids on dynamically warping grids. IEEE Transactions on Visualization and Computer Graphics. 26(6), 2288–2302.","mla":"Hikaru, Ibayashi, et al. “Simulating Liquids on Dynamically Warping Grids.” IEEE Transactions on Visualization and Computer Graphics, vol. 26, no. 6, IEEE, 2020, pp. 2288–302, doi:10.1109/TVCG.2018.2883628.","apa":"Hikaru, I., Wojtan, C., Thuerey, N., Igarashi, T., & Ando, R. (2020). Simulating liquids on dynamically warping grids. 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This research was supported by the Scientific Ser-vice Units (SSU) of IST Austria through resources providedby Scientific Computing. We would like to express my grati-tude to Nobuyuki Umetani and Tomas Skrivan for insight-ful discussion.","publication_identifier":{"issn":["1077-2626"],"eissn":["1941-0506"]},"pmid":1,"title":"Simulating liquids on dynamically warping grids"},{"department":[{"_id":"LaEr"}],"article_processing_charge":"No","volume":48,"isi":1,"month":"03","abstract":[{"text":"We prove edge universality for a general class of correlated real symmetric or complex Hermitian Wigner matrices with arbitrary expectation. Our theorem also applies to internal edges of the self-consistent density of states. In particular, we establish a strong form of band rigidity which excludes mismatches between location and label of eigenvalues close to internal edges in these general models.","lang":"eng"}],"status":"public","related_material":{"record":[{"status":"public","id":"6179","relation":"dissertation_contains"},{"relation":"dissertation_contains","status":"public","id":"149"}]},"citation":{"chicago":"Alt, Johannes, László Erdös, Torben H Krüger, and Dominik J Schröder. “Correlated Random Matrices: Band Rigidity and Edge Universality.” Annals of Probability. Institute of Mathematical Statistics, 2020. https://doi.org/10.1214/19-AOP1379.","mla":"Alt, Johannes, et al. “Correlated Random Matrices: Band Rigidity and Edge Universality.” Annals of Probability, vol. 48, no. 2, Institute of Mathematical Statistics, 2020, pp. 963–1001, doi:10.1214/19-AOP1379.","apa":"Alt, J., Erdös, L., Krüger, T. H., & Schröder, D. J. (2020). Correlated random matrices: Band rigidity and edge universality. 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Since the density of states typically exhibits only square root or cubic root cusp singularities, our work complements previous results on the bulk and edge universality and it thus completes the resolution of the Wigner–Dyson–Mehta universality conjecture for the last remaining universality type in the complex Hermitian class. Our analysis holds not only for exact cusps, but approximate cusps as well, where an extended Pearcey process emerges. As a main technical ingredient we prove an optimal local law at the cusp for both symmetry classes. This result is also the key input in the companion paper (Cipolloni et al. in Pure Appl Anal, 2018. arXiv:1811.04055) where the cusp universality for real symmetric Wigner-type matrices is proven. The novel cusp fluctuation mechanism is also essential for the recent results on the spectral radius of non-Hermitian random matrices (Alt et al. in Spectral radius of random matrices with independent entries, 2019. arXiv:1907.13631), and the non-Hermitian edge universality (Cipolloni et al. in Edge universality for non-Hermitian random matrices, 2019. arXiv:1908.00969).","lang":"eng"}],"isi":1,"volume":378,"article_processing_charge":"Yes (via OA deal)","department":[{"_id":"LaEr"}],"related_material":{"record":[{"id":"6179","status":"public","relation":"dissertation_contains"}]},"status":"public","file":[{"file_id":"8771","creator":"dernst","date_created":"2020-11-18T11:14:37Z","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_name":"2020_CommMathPhysics_Erdoes.pdf","file_size":2904574,"date_updated":"2020-11-18T11:14:37Z","checksum":"c3a683e2afdcea27afa6880b01e53dc2","success":1}],"oa_version":"Published Version","citation":{"ista":"Erdös L, Krüger TH, Schröder DJ. 2020. 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The authors are very grateful to Johannes Alt for numerous discussions on the Dyson equation and for his invaluable help in adjusting [10] to the needs of the present work.","intvolume":" 378","year":"2020"},{"external_id":{"isi":["000498933300001"],"pmid":["33223567"],"arxiv":["1811.04572"]},"day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"},{"call_identifier":"H2020","_id":"256E75B8-B435-11E9-9278-68D0E5697425","name":"Optimal Transport and Stochastic Dynamics","grant_number":"716117"},{"grant_number":"F06504","name":"Taming Complexity in Partial Differential Systems","_id":"260482E2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"page":"319-378","date_updated":"2025-06-12T07:27:20Z","oa":1,"file_date_updated":"2020-07-14T12:47:28Z","publisher":"Springer Nature","has_accepted_license":"1","ddc":["500"],"author":[{"first_name":"Eric A.","last_name":"Carlen","full_name":"Carlen, Eric A."},{"full_name":"Maas, Jan","orcid":"0000-0002-0845-1338","last_name":"Maas","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87","first_name":"Jan"}],"_id":"6358","publication_status":"published","corr_author":"1","quality_controlled":"1","intvolume":" 178","year":"2020","issue":"2","arxiv":1,"publication_identifier":{"eissn":["1572-9613"],"issn":["0022-4715"]},"pmid":1,"title":"Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems","doi":"10.1007/s10955-019-02434-w","type":"journal_article","date_published":"2020-01-01T00:00:00Z","publication":"Journal of Statistical Physics","language":[{"iso":"eng"}],"scopus_import":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2019-04-30T07:34:18Z","ec_funded":1,"article_type":"original","citation":{"mla":"Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport and Functional Inequalities in Dissipative Quantum Systems.” Journal of Statistical Physics, vol. 178, no. 2, Springer Nature, 2020, pp. 319–78, doi:10.1007/s10955-019-02434-w.","apa":"Carlen, E. A., & Maas, J. (2020). Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems. Journal of Statistical Physics. Springer Nature. https://doi.org/10.1007/s10955-019-02434-w","chicago":"Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport and Functional Inequalities in Dissipative Quantum Systems.” Journal of Statistical Physics. Springer Nature, 2020. https://doi.org/10.1007/s10955-019-02434-w.","ista":"Carlen EA, Maas J. 2020. Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems. Journal of Statistical Physics. 178(2), 319–378.","ieee":"E. A. Carlen and J. Maas, “Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems,” Journal of Statistical Physics, vol. 178, no. 2. Springer Nature, pp. 319–378, 2020.","ama":"Carlen EA, Maas J. Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems. Journal of Statistical Physics. 2020;178(2):319-378. doi:10.1007/s10955-019-02434-w","short":"E.A. Carlen, J. Maas, Journal of Statistical Physics 178 (2020) 319–378."},"file":[{"access_level":"open_access","relation":"main_file","date_created":"2019-12-23T12:03:09Z","creator":"dernst","file_id":"7209","checksum":"7b04befbdc0d4982c0ee945d25d19872","file_name":"2019_JourStatistPhysics_Carlen.pdf","file_size":905538,"date_updated":"2020-07-14T12:47:28Z","content_type":"application/pdf"}],"oa_version":"Published Version","status":"public","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1007/s10955-020-02671-4"}]},"department":[{"_id":"JaMa"}],"abstract":[{"lang":"eng","text":"We study dynamical optimal transport metrics between density matricesassociated to symmetric Dirichlet forms on finite-dimensional C∗-algebras. Our settingcovers arbitrary skew-derivations and it provides a unified framework that simultaneously generalizes recently constructed transport metrics for Markov chains, Lindblad equations, and the Fermi Ornstein–Uhlenbeck semigroup. We develop a non-nommutative differential calculus that allows us to obtain non-commutative Ricci curvature bounds, logarithmic Sobolev inequalities, transport-entropy inequalities, andspectral gap estimates."}],"month":"01","volume":178,"isi":1,"article_processing_charge":"Yes (via OA deal)"},{"date_updated":"2023-10-16T09:22:50Z","day":"16","external_id":{"isi":["000550150700001"],"arxiv":["1812.04583"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","publication_status":"published","publisher":"Institute of Mathematical Statistics","_id":"6359","author":[{"first_name":"Konstantinos","last_name":"Dareiotis","full_name":"Dareiotis, Konstantinos"},{"id":"44ECEDF2-F248-11E8-B48F-1D18A9856A87","first_name":"Mate","last_name":"Gerencser","full_name":"Gerencser, Mate"}],"ddc":["510"],"has_accepted_license":"1","file_date_updated":"2020-09-21T13:15:02Z","oa":1,"type":"journal_article","scopus_import":"1","language":[{"iso":"eng"}],"publication":"Electronic Journal of Probability","date_published":"2020-07-16T00:00:00Z","doi":"10.1214/20-EJP479","publication_identifier":{"eissn":["1083-6489"]},"article_number":"82","arxiv":1,"title":"On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift","year":"2020","intvolume":" 25","department":[{"_id":"JaMa"}],"article_processing_charge":"No","volume":25,"isi":1,"abstract":[{"text":"The strong rate of convergence of the Euler-Maruyama scheme for nondegenerate SDEs with irregular drift coefficients is considered. In the case of α-Hölder drift in the recent literature the rate α/2 was proved in many related situations. By exploiting the regularising effect of the noise more efficiently, we show that the rate is in fact arbitrarily close to 1/2 for all α>0. The result extends to Dini continuous coefficients, while in d=1 also to all bounded measurable coefficients.","lang":"eng"}],"month":"07","status":"public","citation":{"ieee":"K. Dareiotis and M. Gerencser, “On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift,” Electronic Journal of Probability, vol. 25. Institute of Mathematical Statistics, 2020.","ista":"Dareiotis K, Gerencser M. 2020. On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. 25, 82.","chicago":"Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the Noise for the Euler-Maruyama Scheme with Irregular Drift.” Electronic Journal of Probability. Institute of Mathematical Statistics, 2020. https://doi.org/10.1214/20-EJP479.","mla":"Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the Noise for the Euler-Maruyama Scheme with Irregular Drift.” Electronic Journal of Probability, vol. 25, 82, Institute of Mathematical Statistics, 2020, doi:10.1214/20-EJP479.","apa":"Dareiotis, K., & Gerencser, M. (2020). On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/20-EJP479","short":"K. Dareiotis, M. Gerencser, Electronic Journal of Probability 25 (2020).","ama":"Dareiotis K, Gerencser M. On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. 2020;25. doi:10.1214/20-EJP479"},"oa_version":"Published Version","file":[{"success":1,"checksum":"8e7c42e72596f6889d786e8e8b89994f","content_type":"application/pdf","file_size":273042,"file_name":"2020_EJournProbab_Dareiotis.pdf","date_updated":"2020-09-21T13:15:02Z","access_level":"open_access","date_created":"2020-09-21T13:15:02Z","creator":"dernst","relation":"main_file","file_id":"8549"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","date_created":"2019-04-30T07:40:17Z"},{"intvolume":" 368","year":"2020","issue":"6496","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"arxiv":1,"pmid":1,"title":"h/e oscillations in interlayer transport of delafossites","doi":"10.1126/science.aay8413","type":"journal_article","publication":"Science","date_published":"2020-06-12T00:00:00Z","language":[{"iso":"eng"}],"scopus_import":"1","date_created":"2025-06-10T09:11:34Z","article_type":"original","citation":{"ieee":"C. Putzke et al., “h/e oscillations in interlayer transport of delafossites,” Science, vol. 368, no. 6496. American Association for the Advancement of Science, pp. 1234–1238, 2020.","ista":"Putzke C, Bachmann MD, McGuinness P, Zhakina E, Sunko V, Konczykowski M, Oka T, Moessner R, Stern A, König M, Khim S, Mackenzie AP, Moll PJW. 2020. h/e oscillations in interlayer transport of delafossites. Science. 368(6496), 1234–1238.","mla":"Putzke, Carsten, et al. “H/e Oscillations in Interlayer Transport of Delafossites.” Science, vol. 368, no. 6496, American Association for the Advancement of Science, 2020, pp. 1234–38, doi:10.1126/science.aay8413.","apa":"Putzke, C., Bachmann, M. D., McGuinness, P., Zhakina, E., Sunko, V., Konczykowski, M., … Moll, P. J. W. (2020). h/e oscillations in interlayer transport of delafossites. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aay8413","chicago":"Putzke, Carsten, Maja D. Bachmann, Philippa McGuinness, Elina Zhakina, Veronika Sunko, Marcin Konczykowski, Takashi Oka, et al. “H/e Oscillations in Interlayer Transport of Delafossites.” Science. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/science.aay8413.","ama":"Putzke C, Bachmann MD, McGuinness P, et al. h/e oscillations in interlayer transport of delafossites. Science. 2020;368(6496):1234-1238. doi:10.1126/science.aay8413","short":"C. Putzke, M.D. Bachmann, P. McGuinness, E. Zhakina, V. Sunko, M. Konczykowski, T. Oka, R. Moessner, A. Stern, M. König, S. Khim, A.P. Mackenzie, P.J.W. Moll, Science 368 (2020) 1234–1238."},"extern":"1","OA_place":"repository","oa_version":"Preprint","status":"public","month":"06","abstract":[{"text":"Microstructures can be carefully designed to reveal the quantum phase of the wave-like nature of electrons in a metal. Here, we report phase-coherent oscillations of out-of-plane magnetoresistance in the layered delafossites PdCoO2 and PtCoO2. The oscillation period is equivalent to that determined by the magnetic flux quantum, h/e, threading an area defined by the atomic interlayer separation and the sample width, where h is Planck’s constant and e is the charge of an electron. The phase of the electron wave function appears robust over length scales exceeding 10 micrometers and persisting up to temperatures of T > 50 kelvin. We show that the experimental signal stems from a periodic field modulation of the out-of-plane hopping. These results demonstrate extraordinary single-particle quantum coherence lengths in delafossites.","lang":"eng"}],"volume":368,"article_processing_charge":"No","day":"12","external_id":{"pmid":["32527829"],"arxiv":["1902.07331"]},"OA_type":"green","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"1234-1238","date_updated":"2025-06-10T11:27:54Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1902.07331"}],"oa":1,"publisher":"American Association for the Advancement of Science","author":[{"first_name":"Carsten","last_name":"Putzke","full_name":"Putzke, Carsten"},{"first_name":"Maja D.","last_name":"Bachmann","full_name":"Bachmann, Maja D."},{"first_name":"Philippa","full_name":"McGuinness, Philippa","last_name":"McGuinness"},{"last_name":"Zhakina","full_name":"Zhakina, Elina","first_name":"Elina"},{"orcid":"0000-0003-2724-3523","last_name":"Sunko","full_name":"Sunko, Veronika","first_name":"Veronika","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3"},{"first_name":"Marcin","last_name":"Konczykowski","full_name":"Konczykowski, Marcin"},{"last_name":"Oka","full_name":"Oka, Takashi","first_name":"Takashi"},{"last_name":"Moessner","full_name":"Moessner, Roderich","first_name":"Roderich"},{"first_name":"Ady","last_name":"Stern","full_name":"Stern, Ady"},{"full_name":"König, Markus","last_name":"König","first_name":"Markus"},{"full_name":"Khim, Seunghyun","last_name":"Khim","first_name":"Seunghyun"},{"full_name":"Mackenzie, Andrew P.","last_name":"Mackenzie","first_name":"Andrew P."},{"first_name":"Philip J.W.","full_name":"Moll, Philip J.W.","last_name":"Moll"}],"_id":"19807","publication_status":"published","quality_controlled":"1"},{"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","date_created":"2025-06-10T09:14:20Z","extern":"1","OA_place":"publisher","citation":{"ista":"Sunko V, Mazzola F, Kitamura S, Khim S, Kushwaha P, Clark OJ, Watson MD, Marković I, Biswas D, Pourovskii L, Kim TK, Lee T-L, Thakur PK, Rosner H, Georges A, Moessner R, Oka T, Mackenzie AP, King PDC. 2020. Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. 6(6), aaz0611.","ieee":"V. Sunko et al., “Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system,” Science Advances, vol. 6, no. 6. American Association for the Advancement of Science, 2020.","mla":"Sunko, Veronika, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission in a Coupled Metallic/Mott Insulator System.” Science Advances, vol. 6, no. 6, aaz0611, American Association for the Advancement of Science, 2020, doi:10.1126/sciadv.aaz0611.","apa":"Sunko, V., Mazzola, F., Kitamura, S., Khim, S., Kushwaha, P., Clark, O. J., … King, P. D. C. (2020). Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.aaz0611","chicago":"Sunko, Veronika, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O. J. Clark, M. D. Watson, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission in a Coupled Metallic/Mott Insulator System.” Science Advances. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/sciadv.aaz0611.","ama":"Sunko V, Mazzola F, Kitamura S, et al. Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. 2020;6(6). doi:10.1126/sciadv.aaz0611","short":"V. Sunko, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O.J. Clark, M.D. Watson, I. Marković, D. Biswas, L. Pourovskii, T.K. Kim, T.-L. Lee, P.K. Thakur, H. Rosner, A. Georges, R. Moessner, T. Oka, A.P. Mackenzie, P.D.C. King, Science Advances 6 (2020)."},"oa_version":"Published Version","status":"public","article_processing_charge":"Yes","month":"02","volume":6,"abstract":[{"lang":"eng","text":"A nearly free electron metal and a Mott insulating state can be thought of as opposite ends of the spectrum of possibilities for the motion of electrons in a solid. Understanding their interaction lies at the heart of the correlated electron problem. In the magnetic oxide metal PdCrO2, nearly free and Mott-localized electrons exist in alternating layers, forming natural heterostructures. Using angle-resolved photoemission spectroscopy, quantitatively supported by a strong coupling analysis, we show that the coupling between these layers leads to an “intertwined” excitation that is a convolution of the charge spectrum of the metallic layer and the spin susceptibility of the Mott layer. Our findings establish PdCrO2 as a model system in which to probe Kondo lattice physics and also open new routes to use the a priori nonmagnetic probe of photoemission to gain insights into the spin susceptibility of correlated electron materials."}],"year":"2020","intvolume":" 6","issue":"6","article_number":"aaz0611","arxiv":1,"publication_identifier":{"eissn":["2375-2548"]},"pmid":1,"title":"Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system","doi":"10.1126/sciadv.aaz0611","type":"journal_article","scopus_import":"1","publication":"Science Advances","date_published":"2020-02-07T00:00:00Z","language":[{"iso":"eng"}],"oa":1,"publisher":"American Association for the Advancement of Science","_id":"19812","author":[{"first_name":"Veronika","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","full_name":"Sunko, Veronika","orcid":"0000-0003-2724-3523","last_name":"Sunko"},{"first_name":"F.","full_name":"Mazzola, F.","last_name":"Mazzola"},{"first_name":"S.","full_name":"Kitamura, S.","last_name":"Kitamura"},{"last_name":"Khim","full_name":"Khim, S.","first_name":"S."},{"first_name":"P.","last_name":"Kushwaha","full_name":"Kushwaha, P."},{"last_name":"Clark","full_name":"Clark, O. J.","first_name":"O. J."},{"first_name":"M. D.","full_name":"Watson, M. D.","last_name":"Watson"},{"last_name":"Marković","full_name":"Marković, I.","first_name":"I."},{"first_name":"D.","full_name":"Biswas, D.","last_name":"Biswas"},{"full_name":"Pourovskii, L.","last_name":"Pourovskii","first_name":"L."},{"first_name":"T. K.","last_name":"Kim","full_name":"Kim, T. K."},{"first_name":"T.-L.","last_name":"Lee","full_name":"Lee, T.-L."},{"first_name":"P. K.","full_name":"Thakur, P. K.","last_name":"Thakur"},{"first_name":"H.","full_name":"Rosner, H.","last_name":"Rosner"},{"full_name":"Georges, A.","last_name":"Georges","first_name":"A."},{"full_name":"Moessner, R.","last_name":"Moessner","first_name":"R."},{"full_name":"Oka, T.","last_name":"Oka","first_name":"T."},{"full_name":"Mackenzie, A. P.","last_name":"Mackenzie","first_name":"A. P."},{"last_name":"King","full_name":"King, P. D. C.","first_name":"P. D. C."}],"has_accepted_license":"1","publication_status":"published","quality_controlled":"1","external_id":{"pmid":["32128385"],"arxiv":["1809.08972"]},"OA_type":"gold","day":"07","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-06-10T13:12:09Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1126/sciadv.aaz0611"}]},{"date_created":"2025-06-10T09:17:59Z","article_type":"original","extern":"1","citation":{"short":"V. Sunko, D. Milosavljević, F. Mazzola, O.J. Clark, U. Burkhardt, T.K. Kim, H. Rosner, Y. Grin, A.P. Mackenzie, P.D.C. King, Physical Review B 102 (2020).","ama":"Sunko V, Milosavljević D, Mazzola F, et al. Surface and bulk electronic structure of aluminium diboride. Physical Review B. 2020;102(3). doi:10.1103/physrevb.102.035143","ieee":"V. Sunko et al., “Surface and bulk electronic structure of aluminium diboride,” Physical Review B, vol. 102, no. 3. American Physical Society, 2020.","ista":"Sunko V, Milosavljević D, Mazzola F, Clark OJ, Burkhardt U, Kim TK, Rosner H, Grin Y, Mackenzie AP, King PDC. 2020. Surface and bulk electronic structure of aluminium diboride. Physical Review B. 102(3), 035143.","chicago":"Sunko, Veronika, D. Milosavljević, F. Mazzola, O. J. Clark, U. Burkhardt, T. K. Kim, H. Rosner, Yu. Grin, A. P. Mackenzie, and P. D. C. King. “Surface and Bulk Electronic Structure of Aluminium Diboride.” Physical Review B. American Physical Society, 2020. https://doi.org/10.1103/physrevb.102.035143.","apa":"Sunko, V., Milosavljević, D., Mazzola, F., Clark, O. J., Burkhardt, U., Kim, T. K., … King, P. D. C. (2020). Surface and bulk electronic structure of aluminium diboride. Physical Review B. American Physical Society. https://doi.org/10.1103/physrevb.102.035143","mla":"Sunko, Veronika, et al. “Surface and Bulk Electronic Structure of Aluminium Diboride.” Physical Review B, vol. 102, no. 3, 035143, American Physical Society, 2020, doi:10.1103/physrevb.102.035143."},"oa_version":"None","status":"public","article_processing_charge":"No","volume":102,"abstract":[{"lang":"eng","text":"We report a combined experimental and theoretical study of the surface and bulk electronic structure of aluminium diboride, a nonsuperconducting sister compound of the superconductor MgB2. We perform angle-resolved photoemission measurements with variable photon energy, and compare them to density functional theory calculations to disentangle the surface and bulk contributions to the measured spectra. Aluminium diboride is known to be aluminium deficient, Al1−𝛿B2, which would be expected to lead to a hole doping as compared to the nominally stoichimoetric compound. Nonetheless, we find that the bulk 𝜎 states, which mediate superconductivity in MgB2, remain more than 600meV below the Fermi level. However, we also observe 𝜎 states originating from the boron terminated surface, with an order of magnitude smaller binding energy of 70meV, and demonstrate how surface hole-doping can bring these across the Fermi level."}],"month":"07","year":"2020","intvolume":" 102","issue":"3","publication_identifier":{"eissn":["2469-9969"],"issn":["2469-9950"]},"article_number":"035143","title":"Surface and bulk electronic structure of aluminium diboride","doi":"10.1103/physrevb.102.035143","type":"journal_article","scopus_import":"1","publication":"Physical Review B","date_published":"2020-07-22T00:00:00Z","language":[{"iso":"eng"}],"publisher":"American Physical Society","_id":"19817","author":[{"first_name":"Veronika","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","orcid":"0000-0003-2724-3523","last_name":"Sunko","full_name":"Sunko, Veronika"},{"first_name":"D.","last_name":"Milosavljević","full_name":"Milosavljević, D."},{"first_name":"F.","full_name":"Mazzola, F.","last_name":"Mazzola"},{"first_name":"O. J.","last_name":"Clark","full_name":"Clark, O. J."},{"first_name":"U.","last_name":"Burkhardt","full_name":"Burkhardt, U."},{"first_name":"T. K.","full_name":"Kim, T. K.","last_name":"Kim"},{"last_name":"Rosner","full_name":"Rosner, H.","first_name":"H."},{"first_name":"Yu.","full_name":"Grin, Yu.","last_name":"Grin"},{"first_name":"A. P.","last_name":"Mackenzie","full_name":"Mackenzie, A. P."},{"full_name":"King, P. D. C.","last_name":"King","first_name":"P. D. C."}],"publication_status":"published","quality_controlled":"1","OA_type":"closed access","day":"22","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-06-10T12:30:48Z"},{"title":"Controlled introduction of defects to delafossite metals by electron irradiation","publication_identifier":{"eissn":["2160-3308"]},"article_number":"021018","arxiv":1,"issue":"2","intvolume":" 10","year":"2020","publication":"Physical Review X","language":[{"iso":"eng"}],"date_published":"2020-04-24T00:00:00Z","scopus_import":"1","type":"journal_article","doi":"10.1103/physrevx.10.021018","oa_version":"Published Version","citation":{"ama":"Sunko V, McGuinness PH, Chang CS, et al. Controlled introduction of defects to delafossite metals by electron irradiation. Physical Review X. 2020;10(2). doi:10.1103/physrevx.10.021018","short":"V. Sunko, P.H. McGuinness, C.S. Chang, E. Zhakina, S. Khim, C.E. Dreyer, M. Konczykowski, H. Borrmann, P.J.W. Moll, M. König, D.A. Muller, A.P. Mackenzie, Physical Review X 10 (2020).","ista":"Sunko V, McGuinness PH, Chang CS, Zhakina E, Khim S, Dreyer CE, Konczykowski M, Borrmann H, Moll PJW, König M, Muller DA, Mackenzie AP. 2020. Controlled introduction of defects to delafossite metals by electron irradiation. Physical Review X. 10(2), 021018.","ieee":"V. Sunko et al., “Controlled introduction of defects to delafossite metals by electron irradiation,” Physical Review X, vol. 10, no. 2. American Physical Society, 2020.","mla":"Sunko, Veronika, et al. “Controlled Introduction of Defects to Delafossite Metals by Electron Irradiation.” Physical Review X, vol. 10, no. 2, 021018, American Physical Society, 2020, doi:10.1103/physrevx.10.021018.","apa":"Sunko, V., McGuinness, P. H., Chang, C. S., Zhakina, E., Khim, S., Dreyer, C. E., … Mackenzie, A. P. (2020). Controlled introduction of defects to delafossite metals by electron irradiation. Physical Review X. American Physical Society. https://doi.org/10.1103/physrevx.10.021018","chicago":"Sunko, Veronika, P. H. McGuinness, C. S. Chang, E. Zhakina, S. Khim, C. E. Dreyer, M. Konczykowski, et al. “Controlled Introduction of Defects to Delafossite Metals by Electron Irradiation.” Physical Review X. American Physical Society, 2020. https://doi.org/10.1103/physrevx.10.021018."},"OA_place":"publisher","extern":"1","article_type":"original","date_created":"2025-06-10T09:21:11Z","month":"04","abstract":[{"text":"The delafossite metals PdCoO2, PtCoO2, and PdCrO2 are among the highest conductivity materials known, with low-temperature mean free paths of tens of microns in the best as-grown single crystals. A key question is whether these very low resistive scattering rates result from strongly suppressed backscattering due to special features of the electronic structure or are a consequence of highly unusual levels of crystalline perfection. We report the results of experiments in which high-energy electron irradiation was used to introduce point disorder to the Pd and Pt layers in which the conduction occurs. We obtain the cross section for formation of Frenkel pairs in absolute units, and cross-check our analysis with first-principles calculations of the relevant atomic displacement energies. We observe an increase of resistivity that is linear in defect density with a slope consistent with scattering in the unitary limit. Our results enable us to deduce that the as-grown crystals contain extremely low levels of in-plane defects of approximately 0.001%. This confirms that crystalline perfection is the most important factor in realizing the long mean free paths and highlights how unusual these delafossite metals are in comparison with the vast majority of other multicomponent oxides and alloys. We discuss the implications of our findings for future materials research.","lang":"eng"}],"volume":10,"article_processing_charge":"Yes","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"24","OA_type":"gold","external_id":{"arxiv":["2001.01471"]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1103/PhysRevX.10.021018"}],"date_updated":"2025-06-10T13:08:51Z","author":[{"full_name":"Sunko, Veronika","orcid":"0000-0003-2724-3523","last_name":"Sunko","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","first_name":"Veronika"},{"full_name":"McGuinness, P. H.","last_name":"McGuinness","first_name":"P. H."},{"full_name":"Chang, C. S.","last_name":"Chang","first_name":"C. S."},{"first_name":"E.","full_name":"Zhakina, E.","last_name":"Zhakina"},{"last_name":"Khim","full_name":"Khim, S.","first_name":"S."},{"first_name":"C. E.","last_name":"Dreyer","full_name":"Dreyer, C. E."},{"first_name":"M.","full_name":"Konczykowski, M.","last_name":"Konczykowski"},{"first_name":"H.","full_name":"Borrmann, H.","last_name":"Borrmann"},{"last_name":"Moll","full_name":"Moll, P. J. W.","first_name":"P. J. W."},{"first_name":"M.","full_name":"König, M.","last_name":"König"},{"last_name":"Muller","full_name":"Muller, D. A.","first_name":"D. A."},{"full_name":"Mackenzie, A. P.","last_name":"Mackenzie","first_name":"A. P."}],"_id":"19823","publisher":"American Physical Society","oa":1,"quality_controlled":"1","DOAJ_listed":"1","publication_status":"published"},{"status":"public","department":[{"_id":"KrCh"}],"abstract":[{"text":"For non-probabilistic programs, a key question in static analysis is termination, which asks whether a given program terminates under a given initial condition. In the presence of probabilistic behaviour, there are two fundamental extensions of the termination question: (a) the almost-sure termination question, which asks whether the termination probability is 1; and (b) the bounded-time termination question, which asks whether the expected termination time is bounded. There are many active research directions to address these two questions; one important such direction is the use of martingale theory for termination analysis. In this chapter, we survey the main techniques of the martingale-based approach to the termination analysis of probabilistic programs.","lang":"eng"}],"month":"11","article_processing_charge":"No","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2025-07-10T13:28:51Z","citation":{"chicago":"Chatterjee, Krishnendu, Hongfei Fu, and Petr Novotný. “Termination Analysis of Probabilistic Programs with Martingales.” In Foundations of Probabilistic Programming, 221–58. Cambridge University Press, 2020. https://doi.org/10.1017/9781108770750.008.","apa":"Chatterjee, K., Fu, H., & Novotný, P. (2020). Termination Analysis of Probabilistic Programs with Martingales. In Foundations of Probabilistic Programming (pp. 221–258). Cambridge University Press. https://doi.org/10.1017/9781108770750.008","mla":"Chatterjee, Krishnendu, et al. “Termination Analysis of Probabilistic Programs with Martingales.” Foundations of Probabilistic Programming, Cambridge University Press, 2020, pp. 221–58, doi:10.1017/9781108770750.008.","ista":"Chatterjee K, Fu H, Novotný P. 2020.Termination Analysis of Probabilistic Programs with Martingales. In: Foundations of Probabilistic Programming. , 221–258.","ieee":"K. Chatterjee, H. Fu, and P. Novotný, “Termination Analysis of Probabilistic Programs with Martingales,” in Foundations of Probabilistic Programming, Cambridge University Press, 2020, pp. 221–258.","short":"K. Chatterjee, H. Fu, P. Novotný, in:, Foundations of Probabilistic Programming, Cambridge University Press, 2020, pp. 221–258.","ama":"Chatterjee K, Fu H, Novotný P. Termination Analysis of Probabilistic Programs with Martingales. In: Foundations of Probabilistic Programming. Cambridge University Press; 2020:221-258. doi:10.1017/9781108770750.008"},"OA_place":"publisher","file":[{"access_level":"open_access","relation":"main_file","date_created":"2025-09-23T12:03:09Z","creator":"dernst","file_id":"20380","success":1,"checksum":"28ece115e8d2d9263e253a598e7caef2","date_updated":"2025-09-23T12:03:09Z","file_size":316681,"file_name":"2020_ProbProgramming_Chatterjee.pdf","content_type":"application/pdf"}],"oa_version":"Published Version","doi":"10.1017/9781108770750.008","type":"book_chapter","date_published":"2020-11-18T00:00:00Z","language":[{"iso":"eng"}],"publication":"Foundations of Probabilistic Programming","year":"2020","acknowledgement":"Krishnendu Chatterjee is supported by the Austrian Science Fund (FWF) NFN\r\nGrant No. S11407-N23 (RiSE/SHiNE), and COST Action GAMENET. Hongfei Fu\r\nis supported by the National Natural Science Foundation of China (NSFC) Grant\r\nNo. 61802254. Petr Novotný is supported by the Czech Science Foundation grant\r\nNo. GJ19-15134Y.","publication_identifier":{"isbn":["9781108488518"],"eisbn":["9781108770750"]},"title":"Termination Analysis of Probabilistic Programs with Martingales","publication_status":"published","corr_author":"1","quality_controlled":"1","oa":1,"file_date_updated":"2025-09-23T12:03:09Z","publisher":"Cambridge University Press","has_accepted_license":"1","ddc":["000"],"author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee","orcid":"0000-0002-4561-241X"},{"first_name":"Hongfei","id":"3AAD03D6-F248-11E8-B48F-1D18A9856A87","last_name":"Fu","full_name":"Fu, Hongfei"},{"last_name":"Novotný","full_name":"Novotný, Petr","id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","first_name":"Petr"}],"_id":"19986","page":"221-258","date_updated":"2025-09-23T12:10:25Z","day":"18","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"Game Theory","_id":"25863FF4-B435-11E9-9278-68D0E5697425","grant_number":"S11407","call_identifier":"FWF"}]},{"article_type":"original","date_created":"2025-12-09T14:25:37Z","OA_place":"repository","extern":"1","citation":{"ama":"Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. 2020;142(25):10914-10920. doi:10.1021/jacs.0c03184","short":"B.N. Bhawal, J. Reisenbauer, C. Ehinger, B. Morandi, Journal of the American Chemical Society 142 (2020) 10914–10920.","mla":"Bhawal, Benjamin N., et al. “Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control.” Journal of the American Chemical Society, vol. 142, no. 25, American Chemical Society, 2020, pp. 10914–20, doi:10.1021/jacs.0c03184.","apa":"Bhawal, B. N., Reisenbauer, J., Ehinger, C., & Morandi, B. (2020). Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. American Chemical Society. https://doi.org/10.1021/jacs.0c03184","chicago":"Bhawal, Benjamin N., Julia Reisenbauer, Christian Ehinger, and Bill Morandi. “Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control.” Journal of the American Chemical Society. American Chemical Society, 2020. https://doi.org/10.1021/jacs.0c03184.","ista":"Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. 2020. Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. 142(25), 10914–10920.","ieee":"B. N. Bhawal, J. Reisenbauer, C. Ehinger, and B. Morandi, “Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control,” Journal of the American Chemical Society, vol. 142, no. 25. American Chemical Society, pp. 10914–10920, 2020."},"oa_version":"Preprint","status":"public","article_processing_charge":"No","volume":142,"abstract":[{"lang":"eng","text":"Reversible catalytic reactions operate under thermodynamic control, and thus, establishing a selective catalytic system poses a considerable challenge. Herein, we report a reversible transfer hydrocyanation protocol that exhibits high selectivity for the thermodynamically less favorable branched isomer. Selectivity is achieved by exploiting the lower barrier for C–CN oxidative addition and reductive elimination at benzylic positions in the absence of a cocatalytic Lewis acid. Through the design of a novel type of HCN donor, a practical, branched-selective, HCN-free transfer hydrocyanation was realized. The synthetically useful resolution of a mixture of branched and linear nitrile isomers was also demonstrated to underline the value of reversible and selective transfer reactions. In a broader context, this work demonstrates that high kinetic selectivity can be achieved in reversible transfer reactions, thus opening new horizons for their synthetic applications."}],"month":"06","year":"2020","intvolume":" 142","issue":"25","pmid":1,"publication_identifier":{"eissn":["1520-5126"],"issn":["0002-7863"]},"title":"Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control","doi":"10.1021/jacs.0c03184","type":"journal_article","scopus_import":"1","language":[{"iso":"eng"}],"publication":"Journal of the American Chemical Society","date_published":"2020-06-01T00:00:00Z","oa":1,"publisher":"American Chemical Society","author":[{"first_name":"Benjamin N.","full_name":"Bhawal, Benjamin N.","last_name":"Bhawal"},{"full_name":"Reisenbauer, Julia","last_name":"Reisenbauer","first_name":"Julia","id":"51d862e9-36ee-11f0-86d3-8534c85a5496"},{"first_name":"Christian","last_name":"Ehinger","full_name":"Ehinger, Christian"},{"last_name":"Morandi","full_name":"Morandi, Bill","first_name":"Bill"}],"_id":"20766","publication_status":"published","quality_controlled":"1","external_id":{"pmid":["32478515"]},"day":"01","OA_type":"green","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"10914-10920","date_updated":"2025-12-16T12:10:08Z","main_file_link":[{"url":"10.26434/chemrxiv.11931633.v1","open_access":"1"}]},{"publisher":"Elsevier","author":[{"first_name":"Lenka","last_name":"Doubravská","full_name":"Doubravská, Lenka"},{"first_name":"Vojtěch","full_name":"Dostál, Vojtěch","last_name":"Dostál"},{"last_name":"Knop","orcid":"0000-0002-3845-3465","full_name":"Knop, Filip","first_name":"Filip","id":"25f3131f-6e7c-11ef-8296-b64ccd4a1b69"},{"last_name":"Libusová","full_name":"Libusová, Lenka","first_name":"Lenka"},{"first_name":"Marie","last_name":"Macůrková","full_name":"Macůrková, Marie"}],"_id":"20806","quality_controlled":"1","publication_status":"published","external_id":{"pmid":["31704058 "]},"OA_type":"closed access","day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-12-15T10:17:13Z","citation":{"ama":"Doubravská L, Dostál V, Knop F, Libusová L, Macůrková M. Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion. Experimental Cell Research. 2020;386(1). doi:10.1016/j.yexcr.2019.111709","short":"L. Doubravská, V. Dostál, F. Knop, L. Libusová, M. Macůrková, Experimental Cell Research 386 (2020).","ista":"Doubravská L, Dostál V, Knop F, Libusová L, Macůrková M. 2020. Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion. Experimental Cell Research. 386(1), 111709.","ieee":"L. Doubravská, V. Dostál, F. Knop, L. Libusová, and M. Macůrková, “Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion,” Experimental Cell Research, vol. 386, no. 1. Elsevier, 2020.","apa":"Doubravská, L., Dostál, V., Knop, F., Libusová, L., & Macůrková, M. (2020). Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion. Experimental Cell Research. Elsevier. https://doi.org/10.1016/j.yexcr.2019.111709","mla":"Doubravská, Lenka, et al. “Human Myotubularin-Related Protein 9 Regulates ER-to-Golgi Trafficking and Modulates WNT3A Secretion.” Experimental Cell Research, vol. 386, no. 1, 111709, Elsevier, 2020, doi:10.1016/j.yexcr.2019.111709.","chicago":"Doubravská, Lenka, Vojtěch Dostál, Filip Knop, Lenka Libusová, and Marie Macůrková. “Human Myotubularin-Related Protein 9 Regulates ER-to-Golgi Trafficking and Modulates WNT3A Secretion.” Experimental Cell Research. Elsevier, 2020. https://doi.org/10.1016/j.yexcr.2019.111709."},"extern":"1","oa_version":"None","article_type":"original","date_created":"2025-12-12T09:03:03Z","month":"01","volume":386,"abstract":[{"text":"Regulation of phosphatidylinositol phosphates plays a crucial role in signal transduction, membrane trafficking or autophagy. Members of the myotubularin family of lipid phosphatases contribute to phosphoinositide metabolism by counteracting the activity of phosphoinositide kinases. The mechanisms determining their subcellular localization and targeting to specific membrane compartments are still poorly understood.\r\nWe show here that the inactive phosphatase MTMR9 localizes to the intermediate compartment and to the Golgi apparatus and is able to recruit its active phosphatase partners MTMR6 and MTMR8 to these locations. Furthermore, MTMR8 and MTMR9 co-localize with the small GTPase RAB1A and regulate its localization. Loss of MTMR9 expression compromises the integrity of the Golgi apparatus and results in altered distribution of RAB1A and actin nucleation-promoting factor WHAMM. Loss or overexpression of MTMR9 leads to decreased rate of protein secretion. We demonstrate that secretion of physiologically relevant cargo exemplified by the WNT3A protein is affected after perturbation of MTMR9 levels.","lang":"eng"}],"article_processing_charge":"No","status":"public","article_number":"111709","publication_identifier":{"issn":["0014-4827"]},"pmid":1,"title":"Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion","intvolume":" 386","year":"2020","issue":"1","type":"journal_article","language":[{"iso":"eng"}],"date_published":"2020-01-01T00:00:00Z","publication":"Experimental Cell Research","scopus_import":"1","doi":"10.1016/j.yexcr.2019.111709"},{"oa":1,"ec_funded":1,"date_created":"2021-09-13T12:17:11Z","citation":{"ista":"Fischer JL, Hensel S, Laux T, Simon T. The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions. arXiv, 2003.05478.","ieee":"J. L. Fischer, S. Hensel, T. Laux, and T. Simon, “The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions,” arXiv. .","mla":"Fischer, Julian L., et al. “The Local Structure of the Energy Landscape in Multiphase Mean Curvature Flow: Weak-Strong Uniqueness and Stability of Evolutions.” ArXiv, 2003.05478, doi:10.48550/arXiv.2003.05478.","apa":"Fischer, J. L., Hensel, S., Laux, T., & Simon, T. (n.d.). The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions. arXiv. https://doi.org/10.48550/arXiv.2003.05478","chicago":"Fischer, Julian L, Sebastian Hensel, Tim Laux, and Thilo Simon. “The Local Structure of the Energy Landscape in Multiphase Mean Curvature Flow: Weak-Strong Uniqueness and Stability of Evolutions.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2003.05478.","ama":"Fischer JL, Hensel S, Laux T, Simon T. The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions. arXiv. doi:10.48550/arXiv.2003.05478","short":"J.L. Fischer, S. Hensel, T. Laux, T. Simon, ArXiv (n.d.)."},"author":[{"last_name":"Fischer","orcid":"0000-0002-0479-558X","full_name":"Fischer, Julian L","first_name":"Julian L","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-7252-8072","last_name":"Hensel","full_name":"Hensel, Sebastian","first_name":"Sebastian","id":"4D23B7DA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Tim","full_name":"Laux, Tim","last_name":"Laux"},{"full_name":"Simon, Thilo","last_name":"Simon","first_name":"Thilo"}],"_id":"10012","oa_version":"Preprint","publication_status":"draft","status":"public","related_material":{"record":[{"id":"10007","status":"public","relation":"dissertation_contains"}]},"department":[{"_id":"JuFi"}],"abstract":[{"lang":"eng","text":"We prove that in the absence of topological changes, the notion of BV solutions to planar multiphase mean curvature flow does not allow for a mechanism for (unphysical) non-uniqueness. Our approach is based on the local structure of the energy landscape near a classical evolution by mean curvature. Mean curvature flow being the gradient flow of the surface energy functional, we develop a gradient-flow analogue of the notion of calibrations. Just like the existence of a calibration guarantees that one has reached a global minimum in the energy landscape, the existence of a \"gradient flow calibration\" ensures that the route of steepest descent in the energy landscape is unique and stable."}],"month":"03","article_processing_charge":"No","day":"11","year":"2020","external_id":{"arxiv":["2003.05478"]},"acknowledgement":"Parts of the paper were written during the visit of the authors to the Hausdorff Research Institute for Mathematics (HIM), University of Bonn, in the framework of the trimester program “Evolution of Interfaces”. The support and the hospitality of HIM are gratefully acknowledged. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 665385.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","arxiv":1,"article_number":"2003.05478","project":[{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020"}],"title":"The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions","date_updated":"2026-04-08T07:01:01Z","doi":"10.48550/arXiv.2003.05478","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2003.05478"}],"type":"preprint","date_published":"2020-03-11T00:00:00Z","language":[{"iso":"eng"}],"publication":"arXiv"},{"oa":1,"_id":"10022","author":[{"id":"35C79D68-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik L","full_name":"Forkert, Dominik L","last_name":"Forkert"},{"last_name":"Maas","orcid":"0000-0002-0845-1338","full_name":"Maas, Jan","first_name":"Jan","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Lorenzo","id":"30AD2CBC-F248-11E8-B48F-1D18A9856A87","last_name":"Portinale","full_name":"Portinale, Lorenzo"}],"publication_status":"draft","corr_author":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"25","external_id":{"arxiv":["2008.10962"]},"project":[{"call_identifier":"H2020","_id":"256E75B8-B435-11E9-9278-68D0E5697425","name":"Optimal Transport and Stochastic Dynamics","grant_number":"716117"},{"grant_number":"F6504","name":"Taming Complexity in Partial Differential Systems","_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2"}],"date_updated":"2026-04-08T07:00:03Z","main_file_link":[{"url":"https://arxiv.org/abs/2008.10962","open_access":"1"}],"ec_funded":1,"date_created":"2021-09-17T10:57:27Z","oa_version":"Preprint","citation":{"ieee":"D. L. Forkert, J. Maas, and L. Portinale, “Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions,” arXiv. .","ista":"Forkert DL, Maas J, Portinale L. Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions. arXiv, 2008.10962.","chicago":"Forkert, Dominik L, Jan Maas, and Lorenzo Portinale. “Evolutionary Γ-Convergence of Entropic Gradient Flow Structures for Fokker-Planck Equations in Multiple Dimensions.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2008.10962.","mla":"Forkert, Dominik L., et al. “Evolutionary Γ-Convergence of Entropic Gradient Flow Structures for Fokker-Planck Equations in Multiple Dimensions.” ArXiv, 2008.10962, doi:10.48550/arXiv.2008.10962.","apa":"Forkert, D. L., Maas, J., & Portinale, L. (n.d.). Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions. arXiv. https://doi.org/10.48550/arXiv.2008.10962","short":"D.L. Forkert, J. Maas, L. Portinale, ArXiv (n.d.).","ama":"Forkert DL, Maas J, Portinale L. Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions. arXiv. doi:10.48550/arXiv.2008.10962"},"related_material":{"record":[{"id":"11739","status":"public","relation":"later_version"},{"relation":"dissertation_contains","id":"10030","status":"public"}]},"status":"public","article_processing_charge":"No","month":"08","abstract":[{"text":"We consider finite-volume approximations of Fokker-Planck equations on bounded convex domains in R^d and study the corresponding gradient flow structures. We reprove the convergence of the discrete to continuous Fokker-Planck equation via the method of Evolutionary Γ-convergence, i.e., we pass to the limit at the level of the gradient flow structures, generalising the one-dimensional result obtained by Disser and Liero. The proof is of variational nature and relies on a Mosco convergence result for functionals in the discrete-to-continuum limit that is of independent interest. Our results apply to arbitrary regular meshes, even though the associated discrete transport distances may fail to converge to the Wasserstein distance in this generality.","lang":"eng"}],"department":[{"_id":"JaMa"}],"acknowledgement":"This work is supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 716117) and by the Austrian Science Fund (FWF), grants No F65 and W1245.","year":"2020","title":"Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions","article_number":"2008.10962","arxiv":1,"doi":"10.48550/arXiv.2008.10962","publication":"arXiv","language":[{"iso":"eng"}],"date_published":"2020-08-25T00:00:00Z","type":"preprint"},{"_id":"10328","oa_version":"None","author":[{"last_name":"Lambert","full_name":"Lambert, Nicholas J.","first_name":"Nicholas J."},{"first_name":"Sonia","full_name":"Mobassem, Sonia","last_name":"Mobassem"},{"first_name":"Alfredo R","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6249-5860","last_name":"Rueda Sanchez","full_name":"Rueda Sanchez, Alfredo R"},{"full_name":"Schwefel, Harald G.L.","last_name":"Schwefel","first_name":"Harald G.L."}],"citation":{"ama":"Lambert NJ, Mobassem S, Rueda Sanchez AR, Schwefel HGL. New designs and noise channels in electro-optic microwave to optical up-conversion. In: OSA Quantum 2.0 Conference. Optica Publishing Group; 2020. doi:10.1364/QUANTUM.2020.QTu8A.1","short":"N.J. Lambert, S. Mobassem, A.R. Rueda Sanchez, H.G.L. Schwefel, in:, OSA Quantum 2.0 Conference, Optica Publishing Group, 2020.","apa":"Lambert, N. J., Mobassem, S., Rueda Sanchez, A. R., & Schwefel, H. G. L. (2020). New designs and noise channels in electro-optic microwave to optical up-conversion. In OSA Quantum 2.0 Conference. Washington, DC, United States: Optica Publishing Group. https://doi.org/10.1364/QUANTUM.2020.QTu8A.1","mla":"Lambert, Nicholas J., et al. “New Designs and Noise Channels in Electro-Optic Microwave to Optical up-Conversion.” OSA Quantum 2.0 Conference, QTu8A.1, Optica Publishing Group, 2020, doi:10.1364/QUANTUM.2020.QTu8A.1.","chicago":"Lambert, Nicholas J., Sonia Mobassem, Alfredo R Rueda Sanchez, and Harald G.L. Schwefel. “New Designs and Noise Channels in Electro-Optic Microwave to Optical up-Conversion.” In OSA Quantum 2.0 Conference. Optica Publishing Group, 2020. https://doi.org/10.1364/QUANTUM.2020.QTu8A.1.","ista":"Lambert NJ, Mobassem S, Rueda Sanchez AR, Schwefel HGL. 2020. New designs and noise channels in electro-optic microwave to optical up-conversion. OSA Quantum 2.0 Conference. OSA: Optical Society of America, OSA Technical Digest, , QTu8A.1.","ieee":"N. J. Lambert, S. Mobassem, A. R. Rueda Sanchez, and H. G. L. Schwefel, “New designs and noise channels in electro-optic microwave to optical up-conversion,” in OSA Quantum 2.0 Conference, Washington, DC, United States, 2020."},"alternative_title":["OSA Technical Digest"],"publisher":"Optica Publishing Group","date_created":"2021-11-21T23:01:31Z","conference":{"end_date":"2020-09-17","location":"Washington, DC, United States","start_date":"2020-09-14","name":"OSA: Optical Society of America"},"month":"01","abstract":[{"text":"We discus noise channels in coherent electro-optic up-conversion between microwave and optical fields, in particular due to optical heating. We also report on a novel configuration, which promises to be flexible and highly efficient.","lang":"eng"}],"article_processing_charge":"No","quality_controlled":"1","department":[{"_id":"JoFi"}],"publication_status":"published","status":"public","title":"New designs and noise channels in electro-optic microwave to optical up-conversion","article_number":"QTu8A.1","publication_identifier":{"isbn":["9-781-5575-2820-9"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2020","day":"01","publication":"OSA Quantum 2.0 Conference","language":[{"iso":"eng"}],"date_published":"2020-01-01T00:00:00Z","scopus_import":"1","type":"conference","date_updated":"2023-10-18T08:32:34Z","doi":"10.1364/QUANTUM.2020.QTu8A.1"},{"publisher":"National Academy of Sciences","author":[{"first_name":"Johannes","full_name":"Krausser, Johannes","last_name":"Krausser"},{"first_name":"Tuomas P. J.","full_name":"Knowles, Tuomas P. J.","last_name":"Knowles"},{"first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","last_name":"Šarić","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela"}],"_id":"10336","oa":1,"quality_controlled":"1","publication_status":"published","day":"16","external_id":{"pmid":["33328273"]},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2019.12.22.886267v2","open_access":"1"}],"page":"33090-33098","date_updated":"2021-11-25T15:35:58Z","extern":"1","citation":{"chicago":"Krausser, Johannes, Tuomas P. J. Knowles, and Anđela Šarić. “Physical Mechanisms of Amyloid Nucleation on Fluid Membranes.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.2007694117.","apa":"Krausser, J., Knowles, T. P. J., & Šarić, A. (2020). Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2007694117","mla":"Krausser, Johannes, et al. “Physical Mechanisms of Amyloid Nucleation on Fluid Membranes.” Proceedings of the National Academy of Sciences, vol. 117, no. 52, National Academy of Sciences, 2020, pp. 33090–98, doi:10.1073/pnas.2007694117.","ieee":"J. Krausser, T. P. J. Knowles, and A. Šarić, “Physical mechanisms of amyloid nucleation on fluid membranes,” Proceedings of the National Academy of Sciences, vol. 117, no. 52. National Academy of Sciences, pp. 33090–33098, 2020.","ista":"Krausser J, Knowles TPJ, Šarić A. 2020. Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. 117(52), 33090–33098.","short":"J. Krausser, T.P.J. Knowles, A. Šarić, Proceedings of the National Academy of Sciences 117 (2020) 33090–33098.","ama":"Krausser J, Knowles TPJ, Šarić A. Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. 2020;117(52):33090-33098. doi:10.1073/pnas.2007694117"},"oa_version":"Published Version","article_type":"original","date_created":"2021-11-25T15:07:09Z","article_processing_charge":"No","volume":117,"month":"12","abstract":[{"text":"Biological membranes can dramatically accelerate the aggregation of normally soluble protein molecules into amyloid fibrils and alter the fibril morphologies, yet the molecular mechanisms through which this accelerated nucleation takes place are not yet understood. Here, we develop a coarse-grained model to systematically explore the effect that the structural properties of the lipid membrane and the nature of protein–membrane interactions have on the nucleation rates of amyloid fibrils. We identify two physically distinct nucleation pathways—protein-rich and lipid-rich—and quantify how the membrane fluidity and protein–membrane affinity control the relative importance of those molecular pathways. We find that the membrane’s susceptibility to reshaping and being incorporated into the fibrillar aggregates is a key determinant of its ability to promote protein aggregation. We then characterize the rates and the free-energy profile associated with this heterogeneous nucleation process, in which the surface itself participates in the aggregate structure. Finally, we compare quantitatively our data to experiments on membrane-catalyzed amyloid aggregation of α-synuclein, a protein implicated in Parkinson’s disease that predominately nucleates on membranes. More generally, our results provide a framework for understanding macromolecular aggregation on lipid membranes in a broad biological and biotechnological context.","lang":"eng"}],"status":"public","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"pmid":1,"title":"Physical mechanisms of amyloid nucleation on fluid membranes","year":"2020","intvolume":" 117","issue":"52","acknowledgement":"We thank T. C. T. Michaels for reading the manuscript. This work was supported by the Academy of Medical Science (J.K. and A.Š.), the Cambridge Center for Misfolding Diseases (T.P.J.K.), the Biotechnology and Biological Sciences Research Council (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the European Research Council Grant PhysProt Agreement 337969, the Wellcome Trust (A.Š. and T.P.J.K.), the Royal Society (A.Š.), the Medical Research Council (J.K. and A.Š.), and the UK Materials and Molecular Modeling Hub for computational resources, which is partially funded by Engineering and Physical Sciences Research Council Grant EP/P020194/1.","type":"journal_article","scopus_import":"1","date_published":"2020-12-16T00:00:00Z","publication":"Proceedings of the National Academy of Sciences","language":[{"iso":"eng"}],"doi":"10.1073/pnas.2007694117"},{"article_type":"original","date_created":"2021-11-26T06:29:41Z","oa_version":"Published Version","citation":{"ama":"Debets VE, Janssen LMC, Šarić A. Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. 2020;16(47):10628-10639. doi:10.1039/d0sm00712a","short":"V.E. Debets, L.M.C. Janssen, A. Šarić, Soft Matter 16 (2020) 10628–10639.","mla":"Debets, V. E., et al. “Characterising the Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” Soft Matter, vol. 16, no. 47, Royal Society of Chemistry, 2020, pp. 10628–39, doi:10.1039/d0sm00712a.","apa":"Debets, V. E., Janssen, L. M. C., & Šarić, A. (2020). Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. Royal Society of Chemistry. https://doi.org/10.1039/d0sm00712a","chicago":"Debets, V. E., L. M. C. Janssen, and Anđela Šarić. “Characterising the Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” Soft Matter. Royal Society of Chemistry, 2020. https://doi.org/10.1039/d0sm00712a.","ieee":"V. E. Debets, L. M. C. Janssen, and A. Šarić, “Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes,” Soft Matter, vol. 16, no. 47. Royal Society of Chemistry, pp. 10628–10639, 2020.","ista":"Debets VE, Janssen LMC, Šarić A. 2020. Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. 16(47), 10628–10639."},"OA_place":"publisher","extern":"1","status":"public","month":"10","volume":16,"abstract":[{"text":"Tracing the motion of macromolecules, viruses, and nanoparticles adsorbed onto cell membranes is currently the most direct way of probing the complex dynamic interactions behind vital biological processes, including cell signalling, trafficking, and viral infection. The resulting trajectories are usually consistent with some type of anomalous diffusion, but the molecular origins behind the observed anomalous behaviour are usually not obvious. Here we use coarse-grained molecular dynamics simulations to help identify the physical mechanisms that can give rise to experimentally observed trajectories of nanoscopic objects moving on biological membranes. We find that diffusion on membranes of high fluidities typically results in normal diffusion of the adsorbed nanoparticle, irrespective of the concentration of receptors, receptor clustering, or multivalent interactions between the particle and membrane receptors. Gel-like membranes on the other hand result in anomalous diffusion of the particle, which becomes more pronounced at higher receptor concentrations. This anomalous diffusion is characterised by local particle trapping in the regions of high receptor concentrations and fast hopping between such regions. The normal diffusion is recovered in the limit where the gel membrane is saturated with receptors. We conclude that hindered receptor diffusivity can be a common reason behind the observed anomalous diffusion of viruses, vesicles, and nanoparticles adsorbed on cell and model membranes. Our results enable direct comparison with experiments and offer a new route for interpreting motility experiments on cell membranes.","lang":"eng"}],"article_processing_charge":"No","issue":"47","acknowledgement":"We thank Jessica McQuade for her input at the start of the project. We acknowledge support from the ERASMUS Placement Programme (V. E. D.), the UCL Institute for the Physics of Living Systems (V. E. D. and A. Š.), the UCL Global Engagement Fund (L. M. C. J.), and the Royal Society (A. Š.).","intvolume":" 16","year":"2020","title":"Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes","publication_identifier":{"issn":["1744-683X","1744-6848"]},"pmid":1,"doi":"10.1039/d0sm00712a","date_published":"2020-10-06T00:00:00Z","language":[{"iso":"eng"}],"publication":"Soft Matter","scopus_import":"1","type":"journal_article","oa":1,"_id":"10341","author":[{"last_name":"Debets","full_name":"Debets, V. E.","first_name":"V. E."},{"first_name":"L. M. C.","last_name":"Janssen","full_name":"Janssen, L. M. C."},{"first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela","last_name":"Šarić","orcid":"0000-0002-7854-2139"}],"publisher":"Royal Society of Chemistry","publication_status":"published","quality_controlled":"1","user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","external_id":{"pmid":["33084724"]},"OA_type":"hybrid","day":"06","keyword":["condensed matter physics","general chemistry"],"date_updated":"2024-10-16T12:53:17Z","page":"10628-10639","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2020.05.01.071761v1","open_access":"1"}]},{"doi":"10.1126/sciadv.abc4397","publication":"Science Advances","date_published":"2020-11-27T00:00:00Z","language":[{"iso":"eng"}],"scopus_import":"1","type":"journal_article","acknowledgement":"Funding: G.B. thanks the ERC for the starting grant (MEViC 278793) and consolidator award (CheSSTaG 769798), EPSRC/BTG Healthcare Partnership (EP/I001697/1), EPSRC Established Career Fellowship (EP/N026322/1), EPSRC/SomaNautix Healthcare Partnership EP/R024723/1, and Children with Cancer UK for the research project (16-227). X.T. and G.B. thank that Anhui 100 Talent program for facilitating data sharing and research visits. A.D.-C. and L.R. acknowledge the Royal Society for a Newton fellowship and the Marie Skłodowska-Curie Actions for a European Fellowship. Author contributions: X.T. prepared and characterized POs, performed all the fast imaging in both conventional and STED microscopy, set up the initial BBB model, encapsulated the PtA2 in POs, and supervised the PtA2-PO animal work. D.M.L. prepared and characterized POs; performed all the permeability studies, PLA assays, WB and associated data analysis, and part of the colocalization assays; and performed experiments with the shRNA for knockdown of syndapin-2. E.S. prepared and characterized POs and performed part of colocalization assays and Cy7-labeled PO animal experiments. S.N. prepared and characterized POs and performed part of the colocalization and inhibition assays. G.F. designed, performed, and analyzed the agent-based simulations of transcytosis. J.F. designed the image-based algorithm to analyze the PLA data. D.M. prepared and characterized POs and helped with Cy7-labeled PO animal experiments. A.A. performed TEM imaging of the POs. A.P. and A.D.-C. synthesized the dye- and peptide-functionalized and pristine copolymers. M.V., L.H.-K., and A.Š. designed, performed, and analyzed the MD simulations. Z.Z. supervised and supported STED imaging. P.X., B.F., and Y.T. synthesized and characterized the PtA2 compound. L.L. performed some of the animal work. L.R. supported and helped with the BBB characterization. G.B. analyzed all fast imaging and supervised and coordinated the overall work. X.T., D.M.L., E.S., and G.B. wrote the manuscript. Competing interests: The authors declare that part of the work is associated with the UCL spin-out company SomaNautix Ltd. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors.","issue":"48","intvolume":" 6","year":"2020","title":"On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias","publication_identifier":{"issn":["2375-2548"]},"pmid":1,"article_number":"eabc4397 ","status":"public","abstract":[{"lang":"eng","text":"The blood-brain barrier is made of polarized brain endothelial cells (BECs) phenotypically conditioned by the central nervous system (CNS). Although transport across BECs is of paramount importance for nutrient uptake as well as ridding the brain of waste products, the intracellular sorting mechanisms that regulate successful receptor-mediated transcytosis in BECs remain to be elucidated. Here, we used a synthetic multivalent system with tunable avidity to the low-density lipoprotein receptor–related protein 1 (LRP1) to investigate the mechanisms of transport across BECs. We used a combination of conventional and super-resolution microscopy, both in vivo and in vitro, accompanied with biophysical modeling of transport kinetics and membrane-bound interactions to elucidate the role of membrane-sculpting protein syndapin-2 on fast transport via tubule formation. We show that high-avidity cargo biases the LRP1 toward internalization associated with fast degradation, while mid-avidity augments the formation of syndapin-2 tubular carriers promoting a fast shuttling across."}],"month":"11","volume":6,"article_processing_charge":"No","date_created":"2021-11-26T06:40:28Z","article_type":"original","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"content_type":"application/pdf","date_updated":"2021-11-26T06:50:09Z","file_size":10381298,"file_name":"2020_SciAdv_Tian.pdf","checksum":"3ba2eca975930cdb0b1ce1ae876885a7","success":1,"file_id":"10343","creator":"cchlebak","date_created":"2021-11-26T06:50:09Z","relation":"main_file","access_level":"open_access"}],"oa_version":"Published Version","citation":{"ieee":"X. Tian et al., “On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias,” Science Advances, vol. 6, no. 48. American Association for the Advancement of Science, 2020.","ista":"Tian X, Leite DM, Scarpa E, Nyberg S, Fullstone G, Forth J, Matias D, Apriceno A, Poma A, Duro-Castano A, Vuyyuru M, Harker-Kirschneck L, Šarić A, Zhang Z, Xiang P, Fang B, Tian Y, Luo L, Rizzello L, Battaglia G. 2020. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. 6(48), eabc4397.","chicago":"Tian, Xiaohe, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone, Joe Forth, Diana Matias, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/sciadv.abc4397.","apa":"Tian, X., Leite, D. M., Scarpa, E., Nyberg, S., Fullstone, G., Forth, J., … Battaglia, G. (2020). On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.abc4397","mla":"Tian, Xiaohe, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances, vol. 6, no. 48, eabc4397, American Association for the Advancement of Science, 2020, doi:10.1126/sciadv.abc4397.","short":"X. Tian, D.M. Leite, E. Scarpa, S. Nyberg, G. Fullstone, J. Forth, D. Matias, A. Apriceno, A. Poma, A. Duro-Castano, M. Vuyyuru, L. Harker-Kirschneck, A. Šarić, Z. Zhang, P. Xiang, B. Fang, Y. Tian, L. Luo, L. Rizzello, G. Battaglia, Science Advances 6 (2020).","ama":"Tian X, Leite DM, Scarpa E, et al. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. 2020;6(48). doi:10.1126/sciadv.abc4397"},"extern":"1","OA_place":"publisher","date_updated":"2024-10-16T12:56:52Z","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2020.04.04.025866v1","open_access":"1"}],"user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","OA_type":"gold","day":"27","external_id":{"pmid":["33246953"]},"keyword":["multidisciplinary"],"DOAJ_listed":"1","publication_status":"published","quality_controlled":"1","oa":1,"file_date_updated":"2021-11-26T06:50:09Z","ddc":["611"],"has_accepted_license":"1","_id":"10342","author":[{"first_name":"Xiaohe","last_name":"Tian","full_name":"Tian, Xiaohe"},{"full_name":"Leite, Diana M.","last_name":"Leite","first_name":"Diana M."},{"last_name":"Scarpa","full_name":"Scarpa, Edoardo","first_name":"Edoardo"},{"first_name":"Sophie","last_name":"Nyberg","full_name":"Nyberg, Sophie"},{"first_name":"Gavin","last_name":"Fullstone","full_name":"Fullstone, Gavin"},{"first_name":"Joe","full_name":"Forth, Joe","last_name":"Forth"},{"first_name":"Diana","last_name":"Matias","full_name":"Matias, Diana"},{"last_name":"Apriceno","full_name":"Apriceno, Azzurra","first_name":"Azzurra"},{"first_name":"Alessandro","last_name":"Poma","full_name":"Poma, Alessandro"},{"first_name":"Aroa","full_name":"Duro-Castano, Aroa","last_name":"Duro-Castano"},{"last_name":"Vuyyuru","full_name":"Vuyyuru, Manish","first_name":"Manish"},{"last_name":"Harker-Kirschneck","full_name":"Harker-Kirschneck, Lena","first_name":"Lena"},{"full_name":"Šarić, Anđela","last_name":"Šarić","orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela"},{"full_name":"Zhang, Zhongping","last_name":"Zhang","first_name":"Zhongping"},{"first_name":"Pan","full_name":"Xiang, Pan","last_name":"Xiang"},{"first_name":"Bin","full_name":"Fang, Bin","last_name":"Fang"},{"full_name":"Tian, Yupeng","last_name":"Tian","first_name":"Yupeng"},{"first_name":"Lei","last_name":"Luo","full_name":"Luo, Lei"},{"full_name":"Rizzello, Loris","last_name":"Rizzello","first_name":"Loris"},{"last_name":"Battaglia","full_name":"Battaglia, Giuseppe","first_name":"Giuseppe"}],"publisher":"American Association for the Advancement of Science"}]