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The authors are very grateful to Johannes Alt for numerous discussions on the Dyson equation and for his invaluable help in adjusting [10] to the needs of the present work.","citation":{"short":"L. Erdös, T.H. Krüger, D.J. Schröder, Communications in Mathematical Physics 378 (2020) 1203–1278.","chicago":"Erdös, László, Torben H Krüger, and Dominik J Schröder. “Cusp Universality for Random Matrices I: Local Law and the Complex Hermitian Case.” Communications in Mathematical Physics. Springer Nature, 2020. https://doi.org/10.1007/s00220-019-03657-4.","ista":"Erdös L, Krüger TH, Schröder DJ. 2020. Cusp universality for random matrices I: Local law and the complex Hermitian case. Communications in Mathematical Physics. 378, 1203–1278.","ama":"Erdös L, Krüger TH, Schröder DJ. Cusp universality for random matrices I: Local law and the complex Hermitian case. Communications in Mathematical Physics. 2020;378:1203-1278. doi:10.1007/s00220-019-03657-4","apa":"Erdös, L., Krüger, T. H., & Schröder, D. J. (2020). Cusp universality for random matrices I: Local law and the complex Hermitian case. Communications in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s00220-019-03657-4","mla":"Erdös, László, et al. “Cusp Universality for Random Matrices I: Local Law and the Complex Hermitian Case.” Communications in Mathematical Physics, vol. 378, Springer Nature, 2020, pp. 1203–78, doi:10.1007/s00220-019-03657-4.","ieee":"L. Erdös, T. H. Krüger, and D. J. Schröder, “Cusp universality for random matrices I: Local law and the complex Hermitian case,” Communications in Mathematical Physics, vol. 378. Springer Nature, pp. 1203–1278, 2020."},"external_id":{"arxiv":["1809.03971"],"isi":["000529483000001"]},"ddc":["530","510"],"publication":"Communications in Mathematical Physics","type":"journal_article","day":"01","abstract":[{"lang":"eng","text":"For complex Wigner-type matrices, i.e. Hermitian random matrices with independent, not necessarily identically distributed entries above the diagonal, we show that at any cusp singularity of the limiting eigenvalue distribution the local eigenvalue statistics are universal and form a Pearcey process. Since the density of states typically exhibits only square root or cubic root cusp singularities, our work complements previous results on the bulk and edge universality and it thus completes the resolution of the Wigner–Dyson–Mehta universality conjecture for the last remaining universality type in the complex Hermitian class. Our analysis holds not only for exact cusps, but approximate cusps as well, where an extended Pearcey process emerges. As a main technical ingredient we prove an optimal local law at the cusp for both symmetry classes. This result is also the key input in the companion paper (Cipolloni et al. in Pure Appl Anal, 2018. arXiv:1811.04055) where the cusp universality for real symmetric Wigner-type matrices is proven. The novel cusp fluctuation mechanism is also essential for the recent results on the spectral radius of non-Hermitian random matrices (Alt et al. in Spectral radius of random matrices with independent entries, 2019. arXiv:1907.13631), and the non-Hermitian edge universality (Cipolloni et al. in Edge universality for non-Hermitian random matrices, 2019. arXiv:1908.00969)."}],"date_created":"2019-03-28T10:21:15Z","file_date_updated":"2020-11-18T11:14:37Z","volume":378,"title":"Cusp universality for random matrices I: Local law and the complex Hermitian case","language":[{"iso":"eng"}],"related_material":{"record":[{"relation":"dissertation_contains","id":"6179","status":"public"}]},"isi":1,"scopus_import":"1"},{"page":"319-378","author":[{"last_name":"Carlen","first_name":"Eric A.","full_name":"Carlen, Eric A."},{"full_name":"Maas, Jan","first_name":"Jan","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0845-1338","last_name":"Maas"}],"quality_controlled":"1","project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"},{"_id":"256E75B8-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"716117","name":"Optimal Transport and Stochastic Dynamics"},{"_id":"260482E2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"F06504","name":"Taming Complexity in Partial Differential Systems"}],"_id":"6358","doi":"10.1007/s10955-019-02434-w","type":"journal_article","publication":"Journal of Statistical Physics","intvolume":" 178","arxiv":1,"external_id":{"isi":["000498933300001"],"pmid":["33223567"],"arxiv":["1811.04572"]},"ddc":["500"],"citation":{"chicago":"Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport and Functional Inequalities in Dissipative Quantum Systems.” Journal of Statistical Physics. Springer Nature, 2020. https://doi.org/10.1007/s10955-019-02434-w.","short":"E.A. Carlen, J. Maas, Journal of Statistical Physics 178 (2020) 319–378.","ista":"Carlen EA, Maas J. 2020. Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems. Journal of Statistical Physics. 178(2), 319–378.","apa":"Carlen, E. A., & Maas, J. (2020). Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems. Journal of Statistical Physics. Springer Nature. https://doi.org/10.1007/s10955-019-02434-w","ama":"Carlen EA, Maas J. Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems. Journal of Statistical Physics. 2020;178(2):319-378. doi:10.1007/s10955-019-02434-w","ieee":"E. A. Carlen and J. Maas, “Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems,” Journal of Statistical Physics, vol. 178, no. 2. Springer Nature, pp. 319–378, 2020.","mla":"Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport and Functional Inequalities in Dissipative Quantum Systems.” Journal of Statistical Physics, vol. 178, no. 2, Springer Nature, 2020, pp. 319–78, doi:10.1007/s10955-019-02434-w."},"volume":178,"file_date_updated":"2020-07-14T12:47:28Z","language":[{"iso":"eng"}],"related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1007/s10955-020-02671-4"}]},"title":"Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems","date_created":"2019-04-30T07:34:18Z","day":"01","abstract":[{"text":"We study dynamical optimal transport metrics between density matricesassociated to symmetric Dirichlet forms on finite-dimensional C∗-algebras. Our settingcovers arbitrary skew-derivations and it provides a unified framework that simultaneously generalizes recently constructed transport metrics for Markov chains, Lindblad equations, and the Fermi Ornstein–Uhlenbeck semigroup. We develop a non-nommutative differential calculus that allows us to obtain non-commutative Ricci curvature bounds, logarithmic Sobolev inequalities, transport-entropy inequalities, andspectral gap estimates.","lang":"eng"}],"isi":1,"scopus_import":"1","pmid":1,"year":"2020","status":"public","issue":"2","has_accepted_license":"1","corr_author":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0022-4715"],"eissn":["1572-9613"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","file":[{"date_updated":"2020-07-14T12:47:28Z","creator":"dernst","access_level":"open_access","content_type":"application/pdf","file_size":905538,"checksum":"7b04befbdc0d4982c0ee945d25d19872","file_id":"7209","file_name":"2019_JourStatistPhysics_Carlen.pdf","date_created":"2019-12-23T12:03:09Z","relation":"main_file"}],"oa":1,"department":[{"_id":"JaMa"}],"article_processing_charge":"Yes (via OA deal)","publication_status":"published","date_updated":"2025-06-12T07:27:20Z","date_published":"2020-01-01T00:00:00Z","month":"01","article_type":"original","ec_funded":1,"publisher":"Springer Nature"},{"type":"journal_article","publication":"Electronic Journal of Probability","citation":{"mla":"Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the Noise for the Euler-Maruyama Scheme with Irregular Drift.” Electronic Journal of Probability, vol. 25, 82, Institute of Mathematical Statistics, 2020, doi:10.1214/20-EJP479.","ieee":"K. Dareiotis and M. Gerencser, “On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift,” Electronic Journal of Probability, vol. 25. Institute of Mathematical Statistics, 2020.","apa":"Dareiotis, K., & Gerencser, M. (2020). On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/20-EJP479","ama":"Dareiotis K, Gerencser M. On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. 2020;25. doi:10.1214/20-EJP479","ista":"Dareiotis K, Gerencser M. 2020. On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. 25, 82.","chicago":"Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the Noise for the Euler-Maruyama Scheme with Irregular Drift.” Electronic Journal of Probability. Institute of Mathematical Statistics, 2020. https://doi.org/10.1214/20-EJP479.","short":"K. Dareiotis, M. Gerencser, Electronic Journal of Probability 25 (2020)."},"external_id":{"arxiv":["1812.04583"],"isi":["000550150700001"]},"ddc":["510"],"arxiv":1,"intvolume":" 25","quality_controlled":"1","author":[{"last_name":"Dareiotis","first_name":"Konstantinos","full_name":"Dareiotis, Konstantinos"},{"last_name":"Gerencser","id":"44ECEDF2-F248-11E8-B48F-1D18A9856A87","full_name":"Gerencser, Mate","first_name":"Mate"}],"doi":"10.1214/20-EJP479","_id":"6359","scopus_import":"1","isi":1,"title":"On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift","language":[{"iso":"eng"}],"file_date_updated":"2020-09-21T13:15:02Z","volume":25,"day":"16","abstract":[{"text":"The strong rate of convergence of the Euler-Maruyama scheme for nondegenerate SDEs with irregular drift coefficients is considered. In the case of α-Hölder drift in the recent literature the rate α/2 was proved in many related situations. By exploiting the regularising effect of the noise more efficiently, we show that the rate is in fact arbitrarily close to 1/2 for all α>0. The result extends to Dini continuous coefficients, while in d=1 also to all bounded measurable coefficients.","lang":"eng"}],"date_created":"2019-04-30T07:40:17Z","publication_identifier":{"eissn":["1083-6489"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"success":1,"file_size":273042,"content_type":"application/pdf","checksum":"8e7c42e72596f6889d786e8e8b89994f","access_level":"open_access","creator":"dernst","date_updated":"2020-09-21T13:15:02Z","relation":"main_file","date_created":"2020-09-21T13:15:02Z","file_name":"2020_EJournProbab_Dareiotis.pdf","file_id":"8549"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"status":"public","year":"2020","has_accepted_license":"1","article_type":"original","month":"07","date_published":"2020-07-16T00:00:00Z","date_updated":"2023-10-16T09:22:50Z","publication_status":"published","publisher":"Institute of Mathematical Statistics","oa":1,"article_processing_charge":"No","department":[{"_id":"JaMa"}],"article_number":"82"},{"status":"public","year":"2020","issue":"6496","OA_place":"repository","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","OA_type":"green","oa":1,"article_processing_charge":"No","month":"06","date_published":"2020-06-12T00:00:00Z","article_type":"original","publication_status":"published","date_updated":"2025-06-10T11:27:54Z","publisher":"American Association for the Advancement of Science","quality_controlled":"1","page":"1234-1238","author":[{"last_name":"Putzke","first_name":"Carsten","full_name":"Putzke, Carsten"},{"first_name":"Maja D.","full_name":"Bachmann, Maja D.","last_name":"Bachmann"},{"first_name":"Philippa","full_name":"McGuinness, Philippa","last_name":"McGuinness"},{"full_name":"Zhakina, Elina","first_name":"Elina","last_name":"Zhakina"},{"id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","full_name":"Sunko, Veronika","first_name":"Veronika","last_name":"Sunko","orcid":"0000-0003-2724-3523"},{"full_name":"Konczykowski, Marcin","first_name":"Marcin","last_name":"Konczykowski"},{"last_name":"Oka","full_name":"Oka, Takashi","first_name":"Takashi"},{"last_name":"Moessner","first_name":"Roderich","full_name":"Moessner, Roderich"},{"last_name":"Stern","full_name":"Stern, Ady","first_name":"Ady"},{"last_name":"König","full_name":"König, Markus","first_name":"Markus"},{"full_name":"Khim, Seunghyun","first_name":"Seunghyun","last_name":"Khim"},{"last_name":"Mackenzie","first_name":"Andrew P.","full_name":"Mackenzie, Andrew P."},{"last_name":"Moll","first_name":"Philip J.W.","full_name":"Moll, Philip J.W."}],"doi":"10.1126/science.aay8413","_id":"19807","publication":"Science","type":"journal_article","citation":{"ista":"Putzke C, Bachmann MD, McGuinness P, Zhakina E, Sunko V, Konczykowski M, Oka T, Moessner R, Stern A, König M, Khim S, Mackenzie AP, Moll PJW. 2020. h/e oscillations in interlayer transport of delafossites. Science. 368(6496), 1234–1238.","short":"C. Putzke, M.D. Bachmann, P. McGuinness, E. Zhakina, V. Sunko, M. Konczykowski, T. Oka, R. Moessner, A. Stern, M. König, S. Khim, A.P. Mackenzie, P.J.W. Moll, Science 368 (2020) 1234–1238.","chicago":"Putzke, Carsten, Maja D. Bachmann, Philippa McGuinness, Elina Zhakina, Veronika Sunko, Marcin Konczykowski, Takashi Oka, et al. “H/e Oscillations in Interlayer Transport of Delafossites.” Science. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/science.aay8413.","ieee":"C. Putzke et al., “h/e oscillations in interlayer transport of delafossites,” Science, vol. 368, no. 6496. American Association for the Advancement of Science, pp. 1234–1238, 2020.","mla":"Putzke, Carsten, et al. “H/e Oscillations in Interlayer Transport of Delafossites.” Science, vol. 368, no. 6496, American Association for the Advancement of Science, 2020, pp. 1234–38, doi:10.1126/science.aay8413.","ama":"Putzke C, Bachmann MD, McGuinness P, et al. h/e oscillations in interlayer transport of delafossites. Science. 2020;368(6496):1234-1238. doi:10.1126/science.aay8413","apa":"Putzke, C., Bachmann, M. D., McGuinness, P., Zhakina, E., Sunko, V., Konczykowski, M., … Moll, P. J. W. (2020). h/e oscillations in interlayer transport of delafossites. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aay8413"},"external_id":{"arxiv":["1902.07331"],"pmid":["32527829"]},"arxiv":1,"intvolume":" 368","title":"h/e oscillations in interlayer transport of delafossites","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1902.07331","open_access":"1"}],"volume":368,"abstract":[{"lang":"eng","text":"Microstructures can be carefully designed to reveal the quantum phase of the wave-like nature of electrons in a metal. Here, we report phase-coherent oscillations of out-of-plane magnetoresistance in the layered delafossites PdCoO2 and PtCoO2. The oscillation period is equivalent to that determined by the magnetic flux quantum, h/e, threading an area defined by the atomic interlayer separation and the sample width, where h is Planck’s constant and e is the charge of an electron. The phase of the electron wave function appears robust over length scales exceeding 10 micrometers and persisting up to temperatures of T > 50 kelvin. We show that the experimental signal stems from a periodic field modulation of the out-of-plane hopping. These results demonstrate extraordinary single-particle quantum coherence lengths in delafossites."}],"day":"12","date_created":"2025-06-10T09:11:34Z","scopus_import":"1","extern":"1","pmid":1},{"publisher":"American Association for the Advancement of Science","date_published":"2020-02-07T00:00:00Z","month":"02","article_type":"original","date_updated":"2025-06-10T13:12:09Z","publication_status":"published","article_number":"aaz0611","article_processing_charge":"Yes","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"gold","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","publication_identifier":{"eissn":["2375-2548"]},"has_accepted_license":"1","status":"public","year":"2020","issue":"6","pmid":1,"scopus_import":"1","extern":"1","abstract":[{"lang":"eng","text":"A nearly free electron metal and a Mott insulating state can be thought of as opposite ends of the spectrum of possibilities for the motion of electrons in a solid. Understanding their interaction lies at the heart of the correlated electron problem. In the magnetic oxide metal PdCrO2, nearly free and Mott-localized electrons exist in alternating layers, forming natural heterostructures. Using angle-resolved photoemission spectroscopy, quantitatively supported by a strong coupling analysis, we show that the coupling between these layers leads to an “intertwined” excitation that is a convolution of the charge spectrum of the metallic layer and the spin susceptibility of the Mott layer. Our findings establish PdCrO2 as a model system in which to probe Kondo lattice physics and also open new routes to use the a priori nonmagnetic probe of photoemission to gain insights into the spin susceptibility of correlated electron materials."}],"day":"07","date_created":"2025-06-10T09:14:20Z","volume":6,"title":"Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system","main_file_link":[{"url":"https://doi.org/10.1126/sciadv.aaz0611","open_access":"1"}],"language":[{"iso":"eng"}],"arxiv":1,"intvolume":" 6","citation":{"apa":"Sunko, V., Mazzola, F., Kitamura, S., Khim, S., Kushwaha, P., Clark, O. J., … King, P. D. C. (2020). Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.aaz0611","ama":"Sunko V, Mazzola F, Kitamura S, et al. Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. 2020;6(6). doi:10.1126/sciadv.aaz0611","ieee":"V. Sunko et al., “Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system,” Science Advances, vol. 6, no. 6. American Association for the Advancement of Science, 2020.","mla":"Sunko, Veronika, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission in a Coupled Metallic/Mott Insulator System.” Science Advances, vol. 6, no. 6, aaz0611, American Association for the Advancement of Science, 2020, doi:10.1126/sciadv.aaz0611.","chicago":"Sunko, Veronika, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O. J. Clark, M. D. Watson, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission in a Coupled Metallic/Mott Insulator System.” Science Advances. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/sciadv.aaz0611.","short":"V. Sunko, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O.J. Clark, M.D. Watson, I. Marković, D. Biswas, L. Pourovskii, T.K. Kim, T.-L. Lee, P.K. Thakur, H. Rosner, A. Georges, R. Moessner, T. Oka, A.P. Mackenzie, P.D.C. King, Science Advances 6 (2020).","ista":"Sunko V, Mazzola F, Kitamura S, Khim S, Kushwaha P, Clark OJ, Watson MD, Marković I, Biswas D, Pourovskii L, Kim TK, Lee T-L, Thakur PK, Rosner H, Georges A, Moessner R, Oka T, Mackenzie AP, King PDC. 2020. Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. 6(6), aaz0611."},"external_id":{"arxiv":["1809.08972"],"pmid":["32128385"]},"type":"journal_article","publication":"Science Advances","doi":"10.1126/sciadv.aaz0611","_id":"19812","author":[{"id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","full_name":"Sunko, Veronika","first_name":"Veronika","last_name":"Sunko","orcid":"0000-0003-2724-3523"},{"last_name":"Mazzola","first_name":"F.","full_name":"Mazzola, F."},{"last_name":"Kitamura","first_name":"S.","full_name":"Kitamura, S."},{"full_name":"Khim, S.","first_name":"S.","last_name":"Khim"},{"full_name":"Kushwaha, P.","first_name":"P.","last_name":"Kushwaha"},{"full_name":"Clark, O. J.","first_name":"O. J.","last_name":"Clark"},{"last_name":"Watson","full_name":"Watson, M. D.","first_name":"M. D."},{"last_name":"Marković","first_name":"I.","full_name":"Marković, I."},{"last_name":"Biswas","full_name":"Biswas, D.","first_name":"D."},{"last_name":"Pourovskii","full_name":"Pourovskii, L.","first_name":"L."},{"last_name":"Kim","first_name":"T. K.","full_name":"Kim, T. K."},{"full_name":"Lee, T.-L.","first_name":"T.-L.","last_name":"Lee"},{"full_name":"Thakur, P. K.","first_name":"P. K.","last_name":"Thakur"},{"last_name":"Rosner","first_name":"H.","full_name":"Rosner, H."},{"last_name":"Georges","first_name":"A.","full_name":"Georges, A."},{"first_name":"R.","full_name":"Moessner, R.","last_name":"Moessner"},{"first_name":"T.","full_name":"Oka, T.","last_name":"Oka"},{"first_name":"A. P.","full_name":"Mackenzie, A. P.","last_name":"Mackenzie"},{"last_name":"King","full_name":"King, P. D. C.","first_name":"P. D. C."}],"quality_controlled":"1"},{"OA_type":"closed access","oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2469-9969"],"issn":["2469-9950"]},"issue":"3","year":"2020","status":"public","publisher":"American Physical Society","date_updated":"2025-06-10T12:30:48Z","publication_status":"published","date_published":"2020-07-22T00:00:00Z","article_type":"original","month":"07","article_number":"035143","article_processing_charge":"No","intvolume":" 102","citation":{"chicago":"Sunko, Veronika, D. Milosavljević, F. Mazzola, O. J. Clark, U. Burkhardt, T. K. Kim, H. Rosner, Yu. Grin, A. P. Mackenzie, and P. D. C. King. “Surface and Bulk Electronic Structure of Aluminium Diboride.” Physical Review B. American Physical Society, 2020. https://doi.org/10.1103/physrevb.102.035143.","short":"V. Sunko, D. Milosavljević, F. Mazzola, O.J. Clark, U. Burkhardt, T.K. Kim, H. Rosner, Y. Grin, A.P. Mackenzie, P.D.C. King, Physical Review B 102 (2020).","ista":"Sunko V, Milosavljević D, Mazzola F, Clark OJ, Burkhardt U, Kim TK, Rosner H, Grin Y, Mackenzie AP, King PDC. 2020. Surface and bulk electronic structure of aluminium diboride. Physical Review B. 102(3), 035143.","apa":"Sunko, V., Milosavljević, D., Mazzola, F., Clark, O. J., Burkhardt, U., Kim, T. K., … King, P. D. C. (2020). Surface and bulk electronic structure of aluminium diboride. Physical Review B. American Physical Society. https://doi.org/10.1103/physrevb.102.035143","ama":"Sunko V, Milosavljević D, Mazzola F, et al. Surface and bulk electronic structure of aluminium diboride. Physical Review B. 2020;102(3). doi:10.1103/physrevb.102.035143","mla":"Sunko, Veronika, et al. “Surface and Bulk Electronic Structure of Aluminium Diboride.” Physical Review B, vol. 102, no. 3, 035143, American Physical Society, 2020, doi:10.1103/physrevb.102.035143.","ieee":"V. Sunko et al., “Surface and bulk electronic structure of aluminium diboride,” Physical Review B, vol. 102, no. 3. American Physical Society, 2020."},"publication":"Physical Review B","type":"journal_article","_id":"19817","doi":"10.1103/physrevb.102.035143","author":[{"last_name":"Sunko","orcid":"0000-0003-2724-3523","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","first_name":"Veronika","full_name":"Sunko, Veronika"},{"last_name":"Milosavljević","full_name":"Milosavljević, D.","first_name":"D."},{"last_name":"Mazzola","full_name":"Mazzola, F.","first_name":"F."},{"first_name":"O. J.","full_name":"Clark, O. J.","last_name":"Clark"},{"last_name":"Burkhardt","first_name":"U.","full_name":"Burkhardt, U."},{"last_name":"Kim","full_name":"Kim, T. K.","first_name":"T. K."},{"first_name":"H.","full_name":"Rosner, H.","last_name":"Rosner"},{"full_name":"Grin, Yu.","first_name":"Yu.","last_name":"Grin"},{"last_name":"Mackenzie","first_name":"A. P.","full_name":"Mackenzie, A. P."},{"first_name":"P. D. C.","full_name":"King, P. D. C.","last_name":"King"}],"quality_controlled":"1","extern":"1","scopus_import":"1","date_created":"2025-06-10T09:17:59Z","abstract":[{"lang":"eng","text":"We report a combined experimental and theoretical study of the surface and bulk electronic structure of aluminium diboride, a nonsuperconducting sister compound of the superconductor MgB2. We perform angle-resolved photoemission measurements with variable photon energy, and compare them to density functional theory calculations to disentangle the surface and bulk contributions to the measured spectra. Aluminium diboride is known to be aluminium deficient, Al1−𝛿B2, which would be expected to lead to a hole doping as compared to the nominally stoichimoetric compound. Nonetheless, we find that the bulk 𝜎 states, which mediate superconductivity in MgB2, remain more than 600meV below the Fermi level. However, we also observe 𝜎 states originating from the boron terminated surface, with an order of magnitude smaller binding energy of 70meV, and demonstrate how surface hole-doping can bring these across the Fermi level."}],"day":"22","volume":102,"language":[{"iso":"eng"}],"title":"Surface and bulk electronic structure of aluminium diboride"},{"_id":"19823","doi":"10.1103/physrevx.10.021018","quality_controlled":"1","author":[{"full_name":"Sunko, Veronika","first_name":"Veronika","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","orcid":"0000-0003-2724-3523","last_name":"Sunko"},{"first_name":"P. H.","full_name":"McGuinness, P. H.","last_name":"McGuinness"},{"last_name":"Chang","full_name":"Chang, C. S.","first_name":"C. S."},{"last_name":"Zhakina","first_name":"E.","full_name":"Zhakina, E."},{"full_name":"Khim, S.","first_name":"S.","last_name":"Khim"},{"last_name":"Dreyer","first_name":"C. E.","full_name":"Dreyer, C. E."},{"full_name":"Konczykowski, M.","first_name":"M.","last_name":"Konczykowski"},{"full_name":"Borrmann, H.","first_name":"H.","last_name":"Borrmann"},{"last_name":"Moll","full_name":"Moll, P. J. W.","first_name":"P. J. W."},{"full_name":"König, M.","first_name":"M.","last_name":"König"},{"first_name":"D. A.","full_name":"Muller, D. A.","last_name":"Muller"},{"last_name":"Mackenzie","full_name":"Mackenzie, A. P.","first_name":"A. P."}],"external_id":{"arxiv":["2001.01471"]},"citation":{"ista":"Sunko V, McGuinness PH, Chang CS, Zhakina E, Khim S, Dreyer CE, Konczykowski M, Borrmann H, Moll PJW, König M, Muller DA, Mackenzie AP. 2020. Controlled introduction of defects to delafossite metals by electron irradiation. Physical Review X. 10(2), 021018.","chicago":"Sunko, Veronika, P. H. McGuinness, C. S. Chang, E. Zhakina, S. Khim, C. E. Dreyer, M. Konczykowski, et al. “Controlled Introduction of Defects to Delafossite Metals by Electron Irradiation.” Physical Review X. American Physical Society, 2020. https://doi.org/10.1103/physrevx.10.021018.","short":"V. Sunko, P.H. McGuinness, C.S. Chang, E. Zhakina, S. Khim, C.E. Dreyer, M. Konczykowski, H. Borrmann, P.J.W. Moll, M. König, D.A. Muller, A.P. Mackenzie, Physical Review X 10 (2020).","mla":"Sunko, Veronika, et al. “Controlled Introduction of Defects to Delafossite Metals by Electron Irradiation.” Physical Review X, vol. 10, no. 2, 021018, American Physical Society, 2020, doi:10.1103/physrevx.10.021018.","ieee":"V. Sunko et al., “Controlled introduction of defects to delafossite metals by electron irradiation,” Physical Review X, vol. 10, no. 2. American Physical Society, 2020.","apa":"Sunko, V., McGuinness, P. H., Chang, C. S., Zhakina, E., Khim, S., Dreyer, C. E., … Mackenzie, A. P. (2020). Controlled introduction of defects to delafossite metals by electron irradiation. Physical Review X. American Physical Society. https://doi.org/10.1103/physrevx.10.021018","ama":"Sunko V, McGuinness PH, Chang CS, et al. Controlled introduction of defects to delafossite metals by electron irradiation. Physical Review X. 2020;10(2). doi:10.1103/physrevx.10.021018"},"intvolume":" 10","arxiv":1,"publication":"Physical Review X","type":"journal_article","date_created":"2025-06-10T09:21:11Z","abstract":[{"lang":"eng","text":"The delafossite metals PdCoO2, PtCoO2, and PdCrO2 are among the highest conductivity materials known, with low-temperature mean free paths of tens of microns in the best as-grown single crystals. A key question is whether these very low resistive scattering rates result from strongly suppressed backscattering due to special features of the electronic structure or are a consequence of highly unusual levels of crystalline perfection. We report the results of experiments in which high-energy electron irradiation was used to introduce point disorder to the Pd and Pt layers in which the conduction occurs. We obtain the cross section for formation of Frenkel pairs in absolute units, and cross-check our analysis with first-principles calculations of the relevant atomic displacement energies. We observe an increase of resistivity that is linear in defect density with a slope consistent with scattering in the unitary limit. Our results enable us to deduce that the as-grown crystals contain extremely low levels of in-plane defects of approximately 0.001%. This confirms that crystalline perfection is the most important factor in realizing the long mean free paths and highlights how unusual these delafossite metals are in comparison with the vast majority of other multicomponent oxides and alloys. We discuss the implications of our findings for future materials research."}],"day":"24","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1103/PhysRevX.10.021018","open_access":"1"}],"title":"Controlled introduction of defects to delafossite metals by electron irradiation","DOAJ_listed":"1","volume":10,"extern":"1","scopus_import":"1","issue":"2","status":"public","year":"2020","oa_version":"Published Version","OA_type":"gold","publication_identifier":{"eissn":["2160-3308"]},"OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"Yes","article_number":"021018","oa":1,"publisher":"American Physical Society","date_updated":"2025-06-10T13:08:51Z","publication_status":"published","article_type":"original","date_published":"2020-04-24T00:00:00Z","month":"04"},{"has_accepted_license":"1","corr_author":"1","year":"2020","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"file":[{"relation":"main_file","file_name":"2020_ProbProgramming_Chatterjee.pdf","date_created":"2025-09-23T12:03:09Z","file_id":"20380","success":1,"creator":"dernst","access_level":"open_access","file_size":316681,"checksum":"28ece115e8d2d9263e253a598e7caef2","content_type":"application/pdf","date_updated":"2025-09-23T12:03:09Z"}],"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","publication_identifier":{"isbn":["9781108488518"],"eisbn":["9781108770750"]},"department":[{"_id":"KrCh"}],"article_processing_charge":"No","oa":1,"publisher":"Cambridge University Press","date_published":"2020-11-18T00:00:00Z","month":"11","publication_status":"published","date_updated":"2025-09-23T12:10:25Z","project":[{"grant_number":"S11407","call_identifier":"FWF","name":"Game Theory","_id":"25863FF4-B435-11E9-9278-68D0E5697425"}],"doi":"10.1017/9781108770750.008","_id":"19986","page":"221-258","author":[{"full_name":"Chatterjee, Krishnendu","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","last_name":"Chatterjee"},{"last_name":"Fu","first_name":"Hongfei","full_name":"Fu, Hongfei","id":"3AAD03D6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Novotný, Petr","first_name":"Petr","id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","last_name":"Novotný"}],"quality_controlled":"1","citation":{"ista":"Chatterjee K, Fu H, Novotný P. 2020.Termination Analysis of Probabilistic Programs with Martingales. In: Foundations of Probabilistic Programming. , 221–258.","short":"K. Chatterjee, H. Fu, P. Novotný, in:, Foundations of Probabilistic Programming, Cambridge University Press, 2020, pp. 221–258.","chicago":"Chatterjee, Krishnendu, Hongfei Fu, and Petr Novotný. “Termination Analysis of Probabilistic Programs with Martingales.” In Foundations of Probabilistic Programming, 221–58. Cambridge University Press, 2020. https://doi.org/10.1017/9781108770750.008.","mla":"Chatterjee, Krishnendu, et al. “Termination Analysis of Probabilistic Programs with Martingales.” Foundations of Probabilistic Programming, Cambridge University Press, 2020, pp. 221–58, doi:10.1017/9781108770750.008.","ieee":"K. Chatterjee, H. Fu, and P. Novotný, “Termination Analysis of Probabilistic Programs with Martingales,” in Foundations of Probabilistic Programming, Cambridge University Press, 2020, pp. 221–258.","ama":"Chatterjee K, Fu H, Novotný P. Termination Analysis of Probabilistic Programs with Martingales. In: Foundations of Probabilistic Programming. Cambridge University Press; 2020:221-258. doi:10.1017/9781108770750.008","apa":"Chatterjee, K., Fu, H., & Novotný, P. (2020). Termination Analysis of Probabilistic Programs with Martingales. In Foundations of Probabilistic Programming (pp. 221–258). Cambridge University Press. https://doi.org/10.1017/9781108770750.008"},"acknowledgement":"Krishnendu Chatterjee is supported by the Austrian Science Fund (FWF) NFN\r\nGrant No. S11407-N23 (RiSE/SHiNE), and COST Action GAMENET. Hongfei Fu\r\nis supported by the National Natural Science Foundation of China (NSFC) Grant\r\nNo. 61802254. Petr Novotný is supported by the Czech Science Foundation grant\r\nNo. GJ19-15134Y.","ddc":["000"],"type":"book_chapter","publication":"Foundations of Probabilistic Programming","abstract":[{"text":"For non-probabilistic programs, a key question in static analysis is termination, which asks whether a given program terminates under a given initial condition. In the presence of probabilistic behaviour, there are two fundamental extensions of the termination question: (a) the almost-sure termination question, which asks whether the termination probability is 1; and (b) the bounded-time termination question, which asks whether the expected termination time is bounded. There are many active research directions to address these two questions; one important such direction is the use of martingale theory for termination analysis. In this chapter, we survey the main techniques of the martingale-based approach to the termination analysis of probabilistic programs.","lang":"eng"}],"day":"18","date_created":"2025-07-10T13:28:51Z","file_date_updated":"2025-09-23T12:03:09Z","title":"Termination Analysis of Probabilistic Programs with Martingales","language":[{"iso":"eng"}]},{"date_created":"2025-12-09T14:25:37Z","day":"01","abstract":[{"text":"Reversible catalytic reactions operate under thermodynamic control, and thus, establishing a selective catalytic system poses a considerable challenge. Herein, we report a reversible transfer hydrocyanation protocol that exhibits high selectivity for the thermodynamically less favorable branched isomer. Selectivity is achieved by exploiting the lower barrier for C–CN oxidative addition and reductive elimination at benzylic positions in the absence of a cocatalytic Lewis acid. Through the design of a novel type of HCN donor, a practical, branched-selective, HCN-free transfer hydrocyanation was realized. The synthetically useful resolution of a mixture of branched and linear nitrile isomers was also demonstrated to underline the value of reversible and selective transfer reactions. In a broader context, this work demonstrates that high kinetic selectivity can be achieved in reversible transfer reactions, thus opening new horizons for their synthetic applications.","lang":"eng"}],"main_file_link":[{"url":"10.26434/chemrxiv.11931633.v1","open_access":"1"}],"language":[{"iso":"eng"}],"title":"Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control","volume":142,"pmid":1,"scopus_import":"1","extern":"1","_id":"20766","doi":"10.1021/jacs.0c03184","quality_controlled":"1","author":[{"first_name":"Benjamin N.","full_name":"Bhawal, Benjamin N.","last_name":"Bhawal"},{"id":"51d862e9-36ee-11f0-86d3-8534c85a5496","full_name":"Reisenbauer, Julia","first_name":"Julia","last_name":"Reisenbauer"},{"full_name":"Ehinger, Christian","first_name":"Christian","last_name":"Ehinger"},{"last_name":"Morandi","first_name":"Bill","full_name":"Morandi, Bill"}],"page":"10914-10920","external_id":{"pmid":["32478515"]},"citation":{"mla":"Bhawal, Benjamin N., et al. “Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control.” Journal of the American Chemical Society, vol. 142, no. 25, American Chemical Society, 2020, pp. 10914–20, doi:10.1021/jacs.0c03184.","ieee":"B. N. Bhawal, J. Reisenbauer, C. Ehinger, and B. Morandi, “Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control,” Journal of the American Chemical Society, vol. 142, no. 25. American Chemical Society, pp. 10914–10920, 2020.","ama":"Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. 2020;142(25):10914-10920. doi:10.1021/jacs.0c03184","apa":"Bhawal, B. N., Reisenbauer, J., Ehinger, C., & Morandi, B. (2020). Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. American Chemical Society. https://doi.org/10.1021/jacs.0c03184","ista":"Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. 2020. Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. 142(25), 10914–10920.","short":"B.N. Bhawal, J. Reisenbauer, C. Ehinger, B. Morandi, Journal of the American Chemical Society 142 (2020) 10914–10920.","chicago":"Bhawal, Benjamin N., Julia Reisenbauer, Christian Ehinger, and Bill Morandi. “Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control.” Journal of the American Chemical Society. American Chemical Society, 2020. https://doi.org/10.1021/jacs.0c03184."},"intvolume":" 142","type":"journal_article","publication":"Journal of the American Chemical Society","article_processing_charge":"No","oa":1,"publisher":"American Chemical Society","publication_status":"published","date_updated":"2025-12-16T12:10:08Z","month":"06","article_type":"original","date_published":"2020-06-01T00:00:00Z","issue":"25","year":"2020","status":"public","oa_version":"Preprint","OA_type":"green","publication_identifier":{"issn":["0002-7863"],"eissn":["1520-5126"]},"OA_place":"repository","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"year":"2020","status":"public","issue":"1","OA_type":"closed access","oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0014-4827"]},"article_number":"111709","article_processing_charge":"No","publisher":"Elsevier","date_published":"2020-01-01T00:00:00Z","article_type":"original","month":"01","publication_status":"published","date_updated":"2025-12-15T10:17:13Z","doi":"10.1016/j.yexcr.2019.111709","_id":"20806","author":[{"full_name":"Doubravská, Lenka","first_name":"Lenka","last_name":"Doubravská"},{"last_name":"Dostál","first_name":"Vojtěch","full_name":"Dostál, Vojtěch"},{"last_name":"Knop","orcid":"0000-0002-3845-3465","id":"25f3131f-6e7c-11ef-8296-b64ccd4a1b69","first_name":"Filip","full_name":"Knop, Filip"},{"full_name":"Libusová, Lenka","first_name":"Lenka","last_name":"Libusová"},{"last_name":"Macůrková","full_name":"Macůrková, Marie","first_name":"Marie"}],"quality_controlled":"1","intvolume":" 386","citation":{"ama":"Doubravská L, Dostál V, Knop F, Libusová L, Macůrková M. Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion. Experimental Cell Research. 2020;386(1). doi:10.1016/j.yexcr.2019.111709","apa":"Doubravská, L., Dostál, V., Knop, F., Libusová, L., & Macůrková, M. (2020). Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion. Experimental Cell Research. Elsevier. https://doi.org/10.1016/j.yexcr.2019.111709","ieee":"L. Doubravská, V. Dostál, F. Knop, L. Libusová, and M. Macůrková, “Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion,” Experimental Cell Research, vol. 386, no. 1. Elsevier, 2020.","mla":"Doubravská, Lenka, et al. “Human Myotubularin-Related Protein 9 Regulates ER-to-Golgi Trafficking and Modulates WNT3A Secretion.” Experimental Cell Research, vol. 386, no. 1, 111709, Elsevier, 2020, doi:10.1016/j.yexcr.2019.111709.","short":"L. Doubravská, V. Dostál, F. Knop, L. Libusová, M. Macůrková, Experimental Cell Research 386 (2020).","chicago":"Doubravská, Lenka, Vojtěch Dostál, Filip Knop, Lenka Libusová, and Marie Macůrková. “Human Myotubularin-Related Protein 9 Regulates ER-to-Golgi Trafficking and Modulates WNT3A Secretion.” Experimental Cell Research. Elsevier, 2020. https://doi.org/10.1016/j.yexcr.2019.111709.","ista":"Doubravská L, Dostál V, Knop F, Libusová L, Macůrková M. 2020. Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion. Experimental Cell Research. 386(1), 111709."},"external_id":{"pmid":["31704058 "]},"type":"journal_article","publication":"Experimental Cell Research","day":"01","abstract":[{"lang":"eng","text":"Regulation of phosphatidylinositol phosphates plays a crucial role in signal transduction, membrane trafficking or autophagy. Members of the myotubularin family of lipid phosphatases contribute to phosphoinositide metabolism by counteracting the activity of phosphoinositide kinases. The mechanisms determining their subcellular localization and targeting to specific membrane compartments are still poorly understood.\r\nWe show here that the inactive phosphatase MTMR9 localizes to the intermediate compartment and to the Golgi apparatus and is able to recruit its active phosphatase partners MTMR6 and MTMR8 to these locations. Furthermore, MTMR8 and MTMR9 co-localize with the small GTPase RAB1A and regulate its localization. Loss of MTMR9 expression compromises the integrity of the Golgi apparatus and results in altered distribution of RAB1A and actin nucleation-promoting factor WHAMM. Loss or overexpression of MTMR9 leads to decreased rate of protein secretion. We demonstrate that secretion of physiologically relevant cargo exemplified by the WNT3A protein is affected after perturbation of MTMR9 levels."}],"date_created":"2025-12-12T09:03:03Z","volume":386,"title":"Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion","language":[{"iso":"eng"}],"pmid":1,"scopus_import":"1","extern":"1"},{"article_number":"2003.05478","department":[{"_id":"JuFi"}],"date_created":"2021-09-13T12:17:11Z","article_processing_charge":"No","day":"11","abstract":[{"lang":"eng","text":"We prove that in the absence of topological changes, the notion of BV solutions to planar multiphase mean curvature flow does not allow for a mechanism for (unphysical) non-uniqueness. Our approach is based on the local structure of the energy landscape near a classical evolution by mean curvature. Mean curvature flow being the gradient flow of the surface energy functional, we develop a gradient-flow analogue of the notion of calibrations. Just like the existence of a calibration guarantees that one has reached a global minimum in the energy landscape, the existence of a \"gradient flow calibration\" ensures that the route of steepest descent in the energy landscape is unique and stable."}],"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"10007"}]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2003.05478"}],"language":[{"iso":"eng"}],"oa":1,"title":"The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions","ec_funded":1,"publication_status":"draft","date_updated":"2026-04-08T07:01:01Z","date_published":"2020-03-11T00:00:00Z","month":"03","project":[{"name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"_id":"10012","doi":"10.48550/arXiv.2003.05478","author":[{"orcid":"0000-0002-0479-558X","last_name":"Fischer","full_name":"Fischer, Julian L","first_name":"Julian L","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hensel","orcid":"0000-0001-7252-8072","id":"4D23B7DA-F248-11E8-B48F-1D18A9856A87","first_name":"Sebastian","full_name":"Hensel, Sebastian"},{"last_name":"Laux","first_name":"Tim","full_name":"Laux, Tim"},{"last_name":"Simon","full_name":"Simon, Thilo","first_name":"Thilo"}],"year":"2020","status":"public","arxiv":1,"external_id":{"arxiv":["2003.05478"]},"oa_version":"Preprint","citation":{"apa":"Fischer, J. L., Hensel, S., Laux, T., & Simon, T. (n.d.). The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions. arXiv. https://doi.org/10.48550/arXiv.2003.05478","ama":"Fischer JL, Hensel S, Laux T, Simon T. The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions. arXiv. doi:10.48550/arXiv.2003.05478","ieee":"J. L. Fischer, S. Hensel, T. Laux, and T. Simon, “The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions,” arXiv. .","mla":"Fischer, Julian L., et al. “The Local Structure of the Energy Landscape in Multiphase Mean Curvature Flow: Weak-Strong Uniqueness and Stability of Evolutions.” ArXiv, 2003.05478, doi:10.48550/arXiv.2003.05478.","chicago":"Fischer, Julian L, Sebastian Hensel, Tim Laux, and Thilo Simon. “The Local Structure of the Energy Landscape in Multiphase Mean Curvature Flow: Weak-Strong Uniqueness and Stability of Evolutions.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2003.05478.","short":"J.L. Fischer, S. Hensel, T. Laux, T. Simon, ArXiv (n.d.).","ista":"Fischer JL, Hensel S, Laux T, Simon T. The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions. arXiv, 2003.05478."},"acknowledgement":"Parts of the paper were written during the visit of the authors to the Hausdorff Research Institute for Mathematics (HIM), University of Bonn, in the framework of the trimester program “Evolution of Interfaces”. The support and the hospitality of HIM are gratefully acknowledged. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 665385.","publication":"arXiv","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"preprint"},{"abstract":[{"lang":"eng","text":"We consider finite-volume approximations of Fokker-Planck equations on bounded convex domains in R^d and study the corresponding gradient flow structures. We reprove the convergence of the discrete to continuous Fokker-Planck equation via the method of Evolutionary Γ-convergence, i.e., we pass to the limit at the level of the gradient flow structures, generalising the one-dimensional result obtained by Disser and Liero. The proof is of variational nature and relies on a Mosco convergence result for functionals in the discrete-to-continuum limit that is of independent interest. Our results apply to arbitrary regular meshes, even though the associated discrete transport distances may fail to converge to the Wasserstein distance in this generality."}],"day":"25","date_created":"2021-09-17T10:57:27Z","title":"Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions","main_file_link":[{"url":"https://arxiv.org/abs/2008.10962","open_access":"1"}],"language":[{"iso":"eng"}],"related_material":{"record":[{"status":"public","id":"11739","relation":"later_version"},{"relation":"dissertation_contains","id":"10030","status":"public"}]},"project":[{"name":"Optimal Transport and Stochastic Dynamics","call_identifier":"H2020","grant_number":"716117","_id":"256E75B8-B435-11E9-9278-68D0E5697425"},{"_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","name":"Taming Complexity in Partial Differential Systems","grant_number":"F6504"}],"doi":"10.48550/arXiv.2008.10962","_id":"10022","author":[{"full_name":"Forkert, Dominik L","first_name":"Dominik L","id":"35C79D68-F248-11E8-B48F-1D18A9856A87","last_name":"Forkert"},{"last_name":"Maas","orcid":"0000-0002-0845-1338","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87","first_name":"Jan","full_name":"Maas, Jan"},{"last_name":"Portinale","id":"30AD2CBC-F248-11E8-B48F-1D18A9856A87","first_name":"Lorenzo","full_name":"Portinale, Lorenzo"}],"arxiv":1,"citation":{"apa":"Forkert, D. L., Maas, J., & Portinale, L. (n.d.). Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions. arXiv. https://doi.org/10.48550/arXiv.2008.10962","ama":"Forkert DL, Maas J, Portinale L. Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions. arXiv. doi:10.48550/arXiv.2008.10962","ieee":"D. L. Forkert, J. Maas, and L. Portinale, “Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions,” arXiv. .","mla":"Forkert, Dominik L., et al. “Evolutionary Γ-Convergence of Entropic Gradient Flow Structures for Fokker-Planck Equations in Multiple Dimensions.” ArXiv, 2008.10962, doi:10.48550/arXiv.2008.10962.","chicago":"Forkert, Dominik L, Jan Maas, and Lorenzo Portinale. “Evolutionary Γ-Convergence of Entropic Gradient Flow Structures for Fokker-Planck Equations in Multiple Dimensions.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2008.10962.","short":"D.L. Forkert, J. Maas, L. Portinale, ArXiv (n.d.).","ista":"Forkert DL, Maas J, Portinale L. Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions. arXiv, 2008.10962."},"acknowledgement":"This work is supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 716117) and by the Austrian Science Fund (FWF), grants No F65 and W1245.","external_id":{"arxiv":["2008.10962"]},"publication":"arXiv","type":"preprint","article_number":"2008.10962","department":[{"_id":"JaMa"}],"article_processing_charge":"No","oa":1,"ec_funded":1,"date_published":"2020-08-25T00:00:00Z","month":"08","publication_status":"draft","date_updated":"2026-04-08T07:00:03Z","corr_author":"1","year":"2020","status":"public","oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"publisher":"Optica Publishing Group","scopus_import":"1","publication_status":"published","date_updated":"2023-10-18T08:32:34Z","date_published":"2020-01-01T00:00:00Z","month":"01","date_created":"2021-11-21T23:01:31Z","abstract":[{"lang":"eng","text":"We discus noise channels in coherent electro-optic up-conversion between microwave and optical fields, in particular due to optical heating. We also report on a novel configuration, which promises to be flexible and highly efficient."}],"article_processing_charge":"No","day":"01","conference":{"end_date":"2020-09-17","location":"Washington, DC, United States","start_date":"2020-09-14","name":"OSA: Optical Society of America"},"department":[{"_id":"JoFi"}],"article_number":"QTu8A.1","language":[{"iso":"eng"}],"title":"New designs and noise channels in electro-optic microwave to optical up-conversion","oa_version":"None","citation":{"mla":"Lambert, Nicholas J., et al. “New Designs and Noise Channels in Electro-Optic Microwave to Optical up-Conversion.” OSA Quantum 2.0 Conference, QTu8A.1, Optica Publishing Group, 2020, doi:10.1364/QUANTUM.2020.QTu8A.1.","ieee":"N. J. Lambert, S. Mobassem, A. R. Rueda Sanchez, and H. G. L. Schwefel, “New designs and noise channels in electro-optic microwave to optical up-conversion,” in OSA Quantum 2.0 Conference, Washington, DC, United States, 2020.","ama":"Lambert NJ, Mobassem S, Rueda Sanchez AR, Schwefel HGL. New designs and noise channels in electro-optic microwave to optical up-conversion. In: OSA Quantum 2.0 Conference. Optica Publishing Group; 2020. doi:10.1364/QUANTUM.2020.QTu8A.1","apa":"Lambert, N. J., Mobassem, S., Rueda Sanchez, A. R., & Schwefel, H. G. L. (2020). New designs and noise channels in electro-optic microwave to optical up-conversion. In OSA Quantum 2.0 Conference. Washington, DC, United States: Optica Publishing Group. https://doi.org/10.1364/QUANTUM.2020.QTu8A.1","ista":"Lambert NJ, Mobassem S, Rueda Sanchez AR, Schwefel HGL. 2020. New designs and noise channels in electro-optic microwave to optical up-conversion. OSA Quantum 2.0 Conference. OSA: Optical Society of America, OSA Technical Digest, , QTu8A.1.","short":"N.J. Lambert, S. Mobassem, A.R. Rueda Sanchez, H.G.L. Schwefel, in:, OSA Quantum 2.0 Conference, Optica Publishing Group, 2020.","chicago":"Lambert, Nicholas J., Sonia Mobassem, Alfredo R Rueda Sanchez, and Harald G.L. Schwefel. “New Designs and Noise Channels in Electro-Optic Microwave to Optical up-Conversion.” In OSA Quantum 2.0 Conference. Optica Publishing Group, 2020. https://doi.org/10.1364/QUANTUM.2020.QTu8A.1."},"alternative_title":["OSA Technical Digest"],"publication_identifier":{"isbn":["9-781-5575-2820-9"]},"type":"conference","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"OSA Quantum 2.0 Conference","_id":"10328","doi":"10.1364/QUANTUM.2020.QTu8A.1","quality_controlled":"1","author":[{"last_name":"Lambert","full_name":"Lambert, Nicholas J.","first_name":"Nicholas J."},{"last_name":"Mobassem","first_name":"Sonia","full_name":"Mobassem, Sonia"},{"full_name":"Rueda Sanchez, Alfredo R","first_name":"Alfredo R","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6249-5860","last_name":"Rueda Sanchez"},{"last_name":"Schwefel","full_name":"Schwefel, Harald G.L.","first_name":"Harald G.L."}],"year":"2020","status":"public"},{"scopus_import":"1","extern":"1","pmid":1,"title":"Physical mechanisms of amyloid nucleation on fluid membranes","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2019.12.22.886267v2","open_access":"1"}],"language":[{"iso":"eng"}],"volume":117,"day":"16","abstract":[{"text":"Biological membranes can dramatically accelerate the aggregation of normally soluble protein molecules into amyloid fibrils and alter the fibril morphologies, yet the molecular mechanisms through which this accelerated nucleation takes place are not yet understood. Here, we develop a coarse-grained model to systematically explore the effect that the structural properties of the lipid membrane and the nature of protein–membrane interactions have on the nucleation rates of amyloid fibrils. We identify two physically distinct nucleation pathways—protein-rich and lipid-rich—and quantify how the membrane fluidity and protein–membrane affinity control the relative importance of those molecular pathways. We find that the membrane’s susceptibility to reshaping and being incorporated into the fibrillar aggregates is a key determinant of its ability to promote protein aggregation. We then characterize the rates and the free-energy profile associated with this heterogeneous nucleation process, in which the surface itself participates in the aggregate structure. Finally, we compare quantitatively our data to experiments on membrane-catalyzed amyloid aggregation of α-synuclein, a protein implicated in Parkinson’s disease that predominately nucleates on membranes. More generally, our results provide a framework for understanding macromolecular aggregation on lipid membranes in a broad biological and biotechnological context.","lang":"eng"}],"date_created":"2021-11-25T15:07:09Z","publication":"Proceedings of the National Academy of Sciences","type":"journal_article","citation":{"short":"J. Krausser, T.P.J. Knowles, A. Šarić, Proceedings of the National Academy of Sciences 117 (2020) 33090–33098.","chicago":"Krausser, Johannes, Tuomas P. J. Knowles, and Anđela Šarić. “Physical Mechanisms of Amyloid Nucleation on Fluid Membranes.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.2007694117.","ista":"Krausser J, Knowles TPJ, Šarić A. 2020. Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. 117(52), 33090–33098.","ama":"Krausser J, Knowles TPJ, Šarić A. Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. 2020;117(52):33090-33098. doi:10.1073/pnas.2007694117","apa":"Krausser, J., Knowles, T. P. J., & Šarić, A. (2020). Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2007694117","mla":"Krausser, Johannes, et al. “Physical Mechanisms of Amyloid Nucleation on Fluid Membranes.” Proceedings of the National Academy of Sciences, vol. 117, no. 52, National Academy of Sciences, 2020, pp. 33090–98, doi:10.1073/pnas.2007694117.","ieee":"J. Krausser, T. P. J. Knowles, and A. Šarić, “Physical mechanisms of amyloid nucleation on fluid membranes,” Proceedings of the National Academy of Sciences, vol. 117, no. 52. National Academy of Sciences, pp. 33090–33098, 2020."},"acknowledgement":"We thank T. C. T. Michaels for reading the manuscript. This work was supported by the Academy of Medical Science (J.K. and A.Š.), the Cambridge Center for Misfolding Diseases (T.P.J.K.), the Biotechnology and Biological Sciences Research Council (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the European Research Council Grant PhysProt Agreement 337969, the Wellcome Trust (A.Š. and T.P.J.K.), the Royal Society (A.Š.), the Medical Research Council (J.K. and A.Š.), and the UK Materials and Molecular Modeling Hub for computational resources, which is partially funded by Engineering and Physical Sciences Research Council Grant EP/P020194/1.","external_id":{"pmid":["33328273"]},"intvolume":" 117","quality_controlled":"1","page":"33090-33098","author":[{"last_name":"Krausser","full_name":"Krausser, Johannes","first_name":"Johannes"},{"first_name":"Tuomas P. J.","full_name":"Knowles, Tuomas P. J.","last_name":"Knowles"},{"last_name":"Šarić","orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela","full_name":"Šarić, Anđela"}],"doi":"10.1073/pnas.2007694117","_id":"10336","article_type":"original","date_published":"2020-12-16T00:00:00Z","month":"12","publication_status":"published","date_updated":"2021-11-25T15:35:58Z","publisher":"National Academy of Sciences","oa":1,"article_processing_charge":"No","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","oa_version":"Published Version","status":"public","issue":"52","year":"2020"},{"intvolume":" 16","acknowledgement":"We thank Jessica McQuade for her input at the start of the project. We acknowledge support from the ERASMUS Placement Programme (V. E. D.), the UCL Institute for the Physics of Living Systems (V. E. D. and A. Š.), the UCL Global Engagement Fund (L. M. C. J.), and the Royal Society (A. Š.).","citation":{"ieee":"V. E. Debets, L. M. C. Janssen, and A. Šarić, “Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes,” Soft Matter, vol. 16, no. 47. Royal Society of Chemistry, pp. 10628–10639, 2020.","mla":"Debets, V. E., et al. “Characterising the Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” Soft Matter, vol. 16, no. 47, Royal Society of Chemistry, 2020, pp. 10628–39, doi:10.1039/d0sm00712a.","ama":"Debets VE, Janssen LMC, Šarić A. Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. 2020;16(47):10628-10639. doi:10.1039/d0sm00712a","apa":"Debets, V. E., Janssen, L. M. C., & Šarić, A. (2020). Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. Royal Society of Chemistry. https://doi.org/10.1039/d0sm00712a","ista":"Debets VE, Janssen LMC, Šarić A. 2020. Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. 16(47), 10628–10639.","short":"V.E. Debets, L.M.C. Janssen, A. Šarić, Soft Matter 16 (2020) 10628–10639.","chicago":"Debets, V. E., L. M. C. Janssen, and Anđela Šarić. “Characterising the Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” Soft Matter. Royal Society of Chemistry, 2020. https://doi.org/10.1039/d0sm00712a."},"external_id":{"pmid":["33084724"]},"publication":"Soft Matter","type":"journal_article","doi":"10.1039/d0sm00712a","_id":"10341","page":"10628-10639","author":[{"full_name":"Debets, V. E.","first_name":"V. E.","last_name":"Debets"},{"full_name":"Janssen, L. M. C.","first_name":"L. M. C.","last_name":"Janssen"},{"orcid":"0000-0002-7854-2139","last_name":"Šarić","full_name":"Šarić, Anđela","first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"}],"quality_controlled":"1","pmid":1,"scopus_import":"1","extern":"1","day":"06","abstract":[{"text":"Tracing the motion of macromolecules, viruses, and nanoparticles adsorbed onto cell membranes is currently the most direct way of probing the complex dynamic interactions behind vital biological processes, including cell signalling, trafficking, and viral infection. The resulting trajectories are usually consistent with some type of anomalous diffusion, but the molecular origins behind the observed anomalous behaviour are usually not obvious. Here we use coarse-grained molecular dynamics simulations to help identify the physical mechanisms that can give rise to experimentally observed trajectories of nanoscopic objects moving on biological membranes. We find that diffusion on membranes of high fluidities typically results in normal diffusion of the adsorbed nanoparticle, irrespective of the concentration of receptors, receptor clustering, or multivalent interactions between the particle and membrane receptors. Gel-like membranes on the other hand result in anomalous diffusion of the particle, which becomes more pronounced at higher receptor concentrations. This anomalous diffusion is characterised by local particle trapping in the regions of high receptor concentrations and fast hopping between such regions. The normal diffusion is recovered in the limit where the gel membrane is saturated with receptors. We conclude that hindered receptor diffusivity can be a common reason behind the observed anomalous diffusion of viruses, vesicles, and nanoparticles adsorbed on cell and model membranes. Our results enable direct comparison with experiments and offer a new route for interpreting motility experiments on cell membranes.","lang":"eng"}],"date_created":"2021-11-26T06:29:41Z","volume":16,"keyword":["condensed matter physics","general chemistry"],"title":"Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2020.05.01.071761v1"}],"OA_type":"hybrid","oa_version":"Published Version","user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","OA_place":"publisher","publication_identifier":{"issn":["1744-683X","1744-6848"]},"issue":"47","status":"public","year":"2020","publisher":"Royal Society of Chemistry","date_published":"2020-10-06T00:00:00Z","article_type":"original","month":"10","date_updated":"2024-10-16T12:53:17Z","publication_status":"published","article_processing_charge":"No","oa":1},{"publisher":"American Association for the Advancement of Science","publication_status":"published","date_updated":"2024-10-16T12:56:52Z","date_published":"2020-11-27T00:00:00Z","month":"11","article_type":"original","article_processing_charge":"No","article_number":"eabc4397 ","oa":1,"oa_version":"Published Version","file":[{"creator":"cchlebak","content_type":"application/pdf","file_size":10381298,"checksum":"3ba2eca975930cdb0b1ce1ae876885a7","access_level":"open_access","success":1,"date_updated":"2021-11-26T06:50:09Z","file_name":"2020_SciAdv_Tian.pdf","date_created":"2021-11-26T06:50:09Z","relation":"main_file","file_id":"10343"}],"OA_type":"gold","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication_identifier":{"issn":["2375-2548"]},"OA_place":"publisher","user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","has_accepted_license":"1","status":"public","year":"2020","issue":"48","pmid":1,"extern":"1","scopus_import":"1","date_created":"2021-11-26T06:40:28Z","abstract":[{"text":"The blood-brain barrier is made of polarized brain endothelial cells (BECs) phenotypically conditioned by the central nervous system (CNS). Although transport across BECs is of paramount importance for nutrient uptake as well as ridding the brain of waste products, the intracellular sorting mechanisms that regulate successful receptor-mediated transcytosis in BECs remain to be elucidated. Here, we used a synthetic multivalent system with tunable avidity to the low-density lipoprotein receptor–related protein 1 (LRP1) to investigate the mechanisms of transport across BECs. We used a combination of conventional and super-resolution microscopy, both in vivo and in vitro, accompanied with biophysical modeling of transport kinetics and membrane-bound interactions to elucidate the role of membrane-sculpting protein syndapin-2 on fast transport via tubule formation. We show that high-avidity cargo biases the LRP1 toward internalization associated with fast degradation, while mid-avidity augments the formation of syndapin-2 tubular carriers promoting a fast shuttling across.","lang":"eng"}],"day":"27","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2020.04.04.025866v1","open_access":"1"}],"title":"On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias","DOAJ_listed":"1","volume":6,"keyword":["multidisciplinary"],"file_date_updated":"2021-11-26T06:50:09Z","ddc":["611"],"external_id":{"pmid":["33246953"]},"citation":{"mla":"Tian, Xiaohe, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances, vol. 6, no. 48, eabc4397, American Association for the Advancement of Science, 2020, doi:10.1126/sciadv.abc4397.","ieee":"X. Tian et al., “On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias,” Science Advances, vol. 6, no. 48. American Association for the Advancement of Science, 2020.","apa":"Tian, X., Leite, D. M., Scarpa, E., Nyberg, S., Fullstone, G., Forth, J., … Battaglia, G. (2020). On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.abc4397","ama":"Tian X, Leite DM, Scarpa E, et al. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. 2020;6(48). doi:10.1126/sciadv.abc4397","ista":"Tian X, Leite DM, Scarpa E, Nyberg S, Fullstone G, Forth J, Matias D, Apriceno A, Poma A, Duro-Castano A, Vuyyuru M, Harker-Kirschneck L, Šarić A, Zhang Z, Xiang P, Fang B, Tian Y, Luo L, Rizzello L, Battaglia G. 2020. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. 6(48), eabc4397.","chicago":"Tian, Xiaohe, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone, Joe Forth, Diana Matias, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/sciadv.abc4397.","short":"X. Tian, D.M. Leite, E. Scarpa, S. Nyberg, G. Fullstone, J. Forth, D. Matias, A. Apriceno, A. Poma, A. Duro-Castano, M. Vuyyuru, L. Harker-Kirschneck, A. Šarić, Z. Zhang, P. Xiang, B. Fang, Y. Tian, L. Luo, L. Rizzello, G. Battaglia, Science Advances 6 (2020)."},"acknowledgement":"Funding: G.B. thanks the ERC for the starting grant (MEViC 278793) and consolidator award (CheSSTaG 769798), EPSRC/BTG Healthcare Partnership (EP/I001697/1), EPSRC Established Career Fellowship (EP/N026322/1), EPSRC/SomaNautix Healthcare Partnership EP/R024723/1, and Children with Cancer UK for the research project (16-227). X.T. and G.B. thank that Anhui 100 Talent program for facilitating data sharing and research visits. A.D.-C. and L.R. acknowledge the Royal Society for a Newton fellowship and the Marie Skłodowska-Curie Actions for a European Fellowship. Author contributions: X.T. prepared and characterized POs, performed all the fast imaging in both conventional and STED microscopy, set up the initial BBB model, encapsulated the PtA2 in POs, and supervised the PtA2-PO animal work. D.M.L. prepared and characterized POs; performed all the permeability studies, PLA assays, WB and associated data analysis, and part of the colocalization assays; and performed experiments with the shRNA for knockdown of syndapin-2. E.S. prepared and characterized POs and performed part of colocalization assays and Cy7-labeled PO animal experiments. S.N. prepared and characterized POs and performed part of the colocalization and inhibition assays. G.F. designed, performed, and analyzed the agent-based simulations of transcytosis. J.F. designed the image-based algorithm to analyze the PLA data. D.M. prepared and characterized POs and helped with Cy7-labeled PO animal experiments. A.A. performed TEM imaging of the POs. A.P. and A.D.-C. synthesized the dye- and peptide-functionalized and pristine copolymers. M.V., L.H.-K., and A.Š. designed, performed, and analyzed the MD simulations. Z.Z. supervised and supported STED imaging. P.X., B.F., and Y.T. synthesized and characterized the PtA2 compound. L.L. performed some of the animal work. L.R. supported and helped with the BBB characterization. G.B. analyzed all fast imaging and supervised and coordinated the overall work. X.T., D.M.L., E.S., and G.B. wrote the manuscript. Competing interests: The authors declare that part of the work is associated with the UCL spin-out company SomaNautix Ltd. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors.","intvolume":" 6","type":"journal_article","publication":"Science Advances","_id":"10342","doi":"10.1126/sciadv.abc4397","quality_controlled":"1","author":[{"last_name":"Tian","first_name":"Xiaohe","full_name":"Tian, Xiaohe"},{"full_name":"Leite, Diana M.","first_name":"Diana M.","last_name":"Leite"},{"last_name":"Scarpa","first_name":"Edoardo","full_name":"Scarpa, Edoardo"},{"last_name":"Nyberg","first_name":"Sophie","full_name":"Nyberg, Sophie"},{"first_name":"Gavin","full_name":"Fullstone, Gavin","last_name":"Fullstone"},{"last_name":"Forth","first_name":"Joe","full_name":"Forth, Joe"},{"first_name":"Diana","full_name":"Matias, Diana","last_name":"Matias"},{"last_name":"Apriceno","first_name":"Azzurra","full_name":"Apriceno, Azzurra"},{"last_name":"Poma","full_name":"Poma, Alessandro","first_name":"Alessandro"},{"last_name":"Duro-Castano","full_name":"Duro-Castano, Aroa","first_name":"Aroa"},{"last_name":"Vuyyuru","full_name":"Vuyyuru, Manish","first_name":"Manish"},{"last_name":"Harker-Kirschneck","first_name":"Lena","full_name":"Harker-Kirschneck, Lena"},{"last_name":"Šarić","orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela","full_name":"Šarić, Anđela"},{"first_name":"Zhongping","full_name":"Zhang, Zhongping","last_name":"Zhang"},{"full_name":"Xiang, Pan","first_name":"Pan","last_name":"Xiang"},{"full_name":"Fang, Bin","first_name":"Bin","last_name":"Fang"},{"last_name":"Tian","full_name":"Tian, Yupeng","first_name":"Yupeng"},{"first_name":"Lei","full_name":"Luo, Lei","last_name":"Luo"},{"full_name":"Rizzello, Loris","first_name":"Loris","last_name":"Rizzello"},{"first_name":"Giuseppe","full_name":"Battaglia, Giuseppe","last_name":"Battaglia"}]},{"issue":"22","year":"2020","status":"public","has_accepted_license":"1","user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","publication_identifier":{"eissn":["1079-7114"],"issn":["0031-9007"]},"OA_place":"publisher","OA_type":"hybrid","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","file":[{"date_updated":"2021-11-26T07:16:49Z","success":1,"creator":"cchlebak","file_size":844353,"checksum":"fbf2e1415e332d6add90222d60401a1d","access_level":"open_access","content_type":"application/pdf","file_id":"10345","relation":"main_file","file_name":"2020_PhysRevLett_Forster.pdf","date_created":"2021-11-26T07:16:49Z"}],"oa":1,"article_number":"228101","article_processing_charge":"No","publication_status":"published","date_updated":"2024-10-16T12:59:57Z","article_type":"original","month":"11","date_published":"2020-11-23T00:00:00Z","publisher":"American Physical Society","author":[{"full_name":"Forster, Joel C.","first_name":"Joel C.","last_name":"Forster"},{"last_name":"Krausser","first_name":"Johannes","full_name":"Krausser, Johannes"},{"first_name":"Manish R.","full_name":"Vuyyuru, Manish R.","last_name":"Vuyyuru"},{"last_name":"Baum","full_name":"Baum, Buzz","first_name":"Buzz"},{"full_name":"Šarić, Anđela","first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139","last_name":"Šarić"}],"quality_controlled":"1","_id":"10344","doi":"10.1103/physrevlett.125.228101","publication":"Physical Review Letters","type":"journal_article","intvolume":" 125","external_id":{"pmid":["33315453"]},"ddc":["530"],"acknowledgement":"We acknowledge support from EPSRC (J. C. F.), MRC (B. B. and A. Š.), the ERC StG 802960 “NEPA” (J. K. and A. Š.), the Royal Society (A. Š.), and the United Kingdom Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC (EP/P020194/1).","citation":{"apa":"Forster, J. C., Krausser, J., Vuyyuru, M. R., Baum, B., & Šarić, A. (2020). Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. American Physical Society. https://doi.org/10.1103/physrevlett.125.228101","ama":"Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. 2020;125(22). doi:10.1103/physrevlett.125.228101","ieee":"J. C. Forster, J. Krausser, M. R. Vuyyuru, B. Baum, and A. Šarić, “Exploring the design rules for efficient membrane-reshaping nanostructures,” Physical Review Letters, vol. 125, no. 22. American Physical Society, 2020.","mla":"Forster, Joel C., et al. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.” Physical Review Letters, vol. 125, no. 22, 228101, American Physical Society, 2020, doi:10.1103/physrevlett.125.228101.","chicago":"Forster, Joel C., Johannes Krausser, Manish R. Vuyyuru, Buzz Baum, and Anđela Šarić. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.” Physical Review Letters. American Physical Society, 2020. https://doi.org/10.1103/physrevlett.125.228101.","short":"J.C. Forster, J. Krausser, M.R. Vuyyuru, B. Baum, A. Šarić, Physical Review Letters 125 (2020).","ista":"Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. 2020. Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. 125(22), 228101."},"volume":125,"file_date_updated":"2021-11-26T07:16:49Z","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2020.02.27.968149v1"}],"language":[{"iso":"eng"}],"title":"Exploring the design rules for efficient membrane-reshaping nanostructures","date_created":"2021-11-26T07:10:43Z","day":"23","abstract":[{"text":"In this study, we investigate the role of the surface patterning of nanostructures for cell membrane reshaping. To accomplish this, we combine an evolutionary algorithm with coarse-grained molecular dynamics simulations and explore the solution space of ligand patterns on a nanoparticle that promote efficient and reliable cell uptake. Surprisingly, we find that in the regime of low ligand number the best-performing structures are characterized by ligands arranged into long one-dimensional chains that pattern the surface of the particle. We show that these chains of ligands provide particles with high rotational freedom and they lower the free energy barrier for membrane crossing. Our approach reveals a set of nonintuitive design rules that can be used to inform artificial nanoparticle construction and the search for inhibitors of viral entry.","lang":"eng"}],"scopus_import":"1","extern":"1","pmid":1},{"date_updated":"2024-10-16T13:05:34Z","publication_status":"published","month":"09","article_type":"original","date_published":"2020-09-23T00:00:00Z","publisher":"Cell Press","oa":1,"article_processing_charge":"No","user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","publication_identifier":{"issn":["0006-3495"]},"OA_place":"publisher","OA_type":"hybrid","oa_version":"Published Version","year":"2020","issue":"9","status":"public","scopus_import":"1","extern":"1","pmid":1,"keyword":["biophysics"],"volume":119,"language":[{"iso":"eng"}],"main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2020.06.08.140061v1","open_access":"1"}],"title":"Modeling fibrillogenesis of collagen-mimetic molecules","date_created":"2021-11-26T07:27:24Z","abstract":[{"lang":"eng","text":"One of the most robust examples of self-assembly in living organisms is the formation of collagen architectures. Collagen type I molecules are a crucial component of the extracellular matrix, where they self-assemble into fibrils of well-defined axial striped patterns. This striped fibrillar pattern is preserved across the animal kingdom and is important for the determination of cell phenotype, cell adhesion, and tissue regulation and signaling. The understanding of the physical processes that determine such a robust morphology of self-assembled collagen fibrils is currently almost completely missing. Here, we develop a minimal coarse-grained computational model to identify the physical principles of the assembly of collagen-mimetic molecules. We find that screened electrostatic interactions can drive the formation of collagen-like filaments of well-defined striped morphologies. The fibril axial pattern is determined solely by the distribution of charges on the molecule and is robust to the changes in protein concentration, monomer rigidity, and environmental conditions. We show that the striped fibrillar pattern cannot be easily predicted from the interactions between two monomers but is an emergent result of multibody interactions. Our results can help address collagen remodeling in diseases and aging and guide the design of collagen scaffolds for biotechnological applications."}],"day":"23","publication":"Biophysical Journal","type":"journal_article","intvolume":" 119","external_id":{"pmid":["33049216"]},"citation":{"ama":"Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal. 2020;119(9):1791-1799. doi:10.1016/j.bpj.2020.09.013","apa":"Hafner, A. E., Gyori, N. G., Bench, C. A., Davis, L. K., & Šarić, A. (2020). Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal. Cell Press. https://doi.org/10.1016/j.bpj.2020.09.013","mla":"Hafner, Anne E., et al. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.” Biophysical Journal, vol. 119, no. 9, Cell Press, 2020, pp. 1791–99, doi:10.1016/j.bpj.2020.09.013.","ieee":"A. E. Hafner, N. G. Gyori, C. A. Bench, L. K. Davis, and A. Šarić, “Modeling fibrillogenesis of collagen-mimetic molecules,” Biophysical Journal, vol. 119, no. 9. Cell Press, pp. 1791–1799, 2020.","short":"A.E. Hafner, N.G. Gyori, C.A. Bench, L.K. Davis, A. Šarić, Biophysical Journal 119 (2020) 1791–1799.","chicago":"Hafner, Anne E., Noemi G. Gyori, Ciaran A. Bench, Luke K. Davis, and Anđela Šarić. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.” Biophysical Journal. Cell Press, 2020. https://doi.org/10.1016/j.bpj.2020.09.013.","ista":"Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. 2020. Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal. 119(9), 1791–1799."},"acknowledgement":"We thank Melinda Duer, Patrick Mesquida, Lucy Colwell, Lucie Liu, Daan Frenkel, and Ivan Palaia for helpful discussions. We acknowledge support from the Engineering and Physical Sciences Research Council (A.E.H., L.K.D., and A.Š.), Biotechnology and Biological Sciences Research Council LIDo programme (N.G.G. and C.A.B.), the Royal Society (A.Š.), and the UK Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC ( EP/P020194/1).","author":[{"full_name":"Hafner, Anne E.","first_name":"Anne E.","last_name":"Hafner"},{"first_name":"Noemi G.","full_name":"Gyori, Noemi G.","last_name":"Gyori"},{"full_name":"Bench, Ciaran A.","first_name":"Ciaran A.","last_name":"Bench"},{"full_name":"Davis, Luke K.","first_name":"Luke K.","last_name":"Davis"},{"first_name":"Anđela","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139","last_name":"Šarić"}],"page":"1791-1799","quality_controlled":"1","_id":"10346","doi":"10.1016/j.bpj.2020.09.013"},{"intvolume":" 117","citation":{"mla":"Michaels, Thomas C. T., et al. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation Inhibitors.” Proceedings of the National Academy of Sciences, vol. 117, no. 39, National Academy of Sciences, 2020, pp. 24251–57, doi:10.1073/pnas.2006684117.","ieee":"T. C. T. Michaels et al., “Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors,” Proceedings of the National Academy of Sciences, vol. 117, no. 39. National Academy of Sciences, pp. 24251–24257, 2020.","apa":"Michaels, T. C. T., Šarić, A., Meisl, G., Heller, G. T., Curk, S., Arosio, P., … Knowles, T. P. J. (2020). Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2006684117","ama":"Michaels TCT, Šarić A, Meisl G, et al. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. 2020;117(39):24251-24257. doi:10.1073/pnas.2006684117","ista":"Michaels TCT, Šarić A, Meisl G, Heller GT, Curk S, Arosio P, Linse S, Dobson CM, Vendruscolo M, Knowles TPJ. 2020. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. 117(39), 24251–24257.","chicago":"Michaels, Thomas C. T., Anđela Šarić, Georg Meisl, Gabriella T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo, and Tuomas P. J. Knowles. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation Inhibitors.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.2006684117.","short":"T.C.T. Michaels, A. Šarić, G. Meisl, G.T. Heller, S. Curk, P. Arosio, S. Linse, C.M. Dobson, M. Vendruscolo, T.P.J. Knowles, Proceedings of the National Academy of Sciences 117 (2020) 24251–24257."},"acknowledgement":"We acknowledge support from Peterhouse, Cambridge (T.C.T.M.); the Swiss National Science Foundation (T.C.T.M.); the Royal Society (A.S. and S.C.); the Academy of Medical Sciences (A.S.); Sidney Sussex College, Cambridge (G.M.); Newnham College, Cambridge (G.T.H.); the Wellcome Trust (T.P.J.K.); the Cambridge Center for Misfolding Diseases (T.P.J.K. and M.V.); the Biotechnology and Biological Sciences Research Council (T.P.J.K.); the Frances and Augustus Newman Foundation (T.P.J.K.); and the Synapsis Foundation for Alzheimer’s disease (P.A.). The research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Seventh Framework Program (FP7/2007-2013) through the ERC Grant PhysProt (Agreement 337969).","external_id":{"pmid":["32929030"]},"publication":"Proceedings of the National Academy of Sciences","type":"journal_article","doi":"10.1073/pnas.2006684117","_id":"10347","page":"24251-24257","author":[{"full_name":"Michaels, Thomas C. T.","first_name":"Thomas C. T.","last_name":"Michaels"},{"orcid":"0000-0002-7854-2139","last_name":"Šarić","first_name":"Anđela","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"},{"last_name":"Meisl","full_name":"Meisl, Georg","first_name":"Georg"},{"full_name":"Heller, Gabriella T.","first_name":"Gabriella T.","last_name":"Heller"},{"full_name":"Curk, Samo","first_name":"Samo","last_name":"Curk"},{"last_name":"Arosio","full_name":"Arosio, Paolo","first_name":"Paolo"},{"last_name":"Linse","full_name":"Linse, Sara","first_name":"Sara"},{"last_name":"Dobson","first_name":"Christopher M.","full_name":"Dobson, Christopher M."},{"last_name":"Vendruscolo","first_name":"Michele","full_name":"Vendruscolo, Michele"},{"full_name":"Knowles, Tuomas P. J.","first_name":"Tuomas P. J.","last_name":"Knowles"}],"quality_controlled":"1","pmid":1,"extern":"1","scopus_import":"1","day":"14","abstract":[{"text":"Understanding the mechanism of action of compounds capable of inhibiting amyloid-fibril formation is critical to the development of potential therapeutics against protein-misfolding diseases. A fundamental challenge for progress is the range of possible target species and the disparate timescales involved, since the aggregating proteins are simultaneously the reactants, products, intermediates, and catalysts of the reaction. It is a complex problem, therefore, to choose the states of the aggregating proteins that should be bound by the compounds to achieve the most potent inhibition. We present here a comprehensive kinetic theory of amyloid-aggregation inhibition that reveals the fundamental thermodynamic and kinetic signatures characterizing effective inhibitors by identifying quantitative relationships between the aggregation and binding rate constants. These results provide general physical laws to guide the design and optimization of inhibitors of amyloid-fibril formation, revealing in particular the important role of on-rates in the binding of the inhibitors.","lang":"eng"}],"date_created":"2021-11-26T07:48:27Z","keyword":["multidisciplinary"],"volume":117,"title":"Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2020.02.22.960716","open_access":"1"}],"oa_version":"Published Version","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"year":"2020","status":"public","issue":"39","publisher":"National Academy of Sciences","date_published":"2020-09-14T00:00:00Z","month":"09","article_type":"original","publication_status":"published","date_updated":"2021-11-26T08:59:06Z","article_processing_charge":"No","oa":1},{"quality_controlled":"1","page":"1140-1155.e18","author":[{"last_name":"Pfitzner","first_name":"Anna-Katharina","full_name":"Pfitzner, Anna-Katharina"},{"last_name":"Mercier","first_name":"Vincent","full_name":"Mercier, Vincent"},{"first_name":"Xiuyun","full_name":"Jiang, Xiuyun","last_name":"Jiang"},{"last_name":"Moser von Filseck","first_name":"Joachim","full_name":"Moser von Filseck, Joachim"},{"first_name":"Buzz","full_name":"Baum, Buzz","last_name":"Baum"},{"full_name":"Šarić, Anđela","first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139","last_name":"Šarić"},{"first_name":"Aurélien","full_name":"Roux, Aurélien","last_name":"Roux"}],"_id":"10348","doi":"10.1016/j.cell.2020.07.021","type":"journal_article","publication":"Cell","external_id":{"pmid":["32814015"]},"citation":{"ieee":"A.-K. Pfitzner et al., “An ESCRT-III polymerization sequence drives membrane deformation and fission,” Cell, vol. 182, no. 5. Elsevier, p. 1140–1155.e18, 2020.","mla":"Pfitzner, Anna-Katharina, et al. “An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission.” Cell, vol. 182, no. 5, Elsevier, 2020, p. 1140–1155.e18, doi:10.1016/j.cell.2020.07.021.","apa":"Pfitzner, A.-K., Mercier, V., Jiang, X., Moser von Filseck, J., Baum, B., Šarić, A., & Roux, A. (2020). An ESCRT-III polymerization sequence drives membrane deformation and fission. Cell. Elsevier. https://doi.org/10.1016/j.cell.2020.07.021","ama":"Pfitzner A-K, Mercier V, Jiang X, et al. An ESCRT-III polymerization sequence drives membrane deformation and fission. Cell. 2020;182(5):1140-1155.e18. doi:10.1016/j.cell.2020.07.021","ista":"Pfitzner A-K, Mercier V, Jiang X, Moser von Filseck J, Baum B, Šarić A, Roux A. 2020. An ESCRT-III polymerization sequence drives membrane deformation and fission. Cell. 182(5), 1140–1155.e18.","chicago":"Pfitzner, Anna-Katharina, Vincent Mercier, Xiuyun Jiang, Joachim Moser von Filseck, Buzz Baum, Anđela Šarić, and Aurélien Roux. “An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission.” Cell. Elsevier, 2020. https://doi.org/10.1016/j.cell.2020.07.021.","short":"A.-K. Pfitzner, V. Mercier, X. Jiang, J. Moser von Filseck, B. Baum, A. Šarić, A. Roux, Cell 182 (2020) 1140–1155.e18."},"acknowledgement":"The authors thank Nicolas Chiaruttini, Jean Gruenberg, and Lena Harker-Kirschneck for careful correction of this manuscript and helpful discussions. The authors want to thank the NCCR Chemical Biology for constant support during this project. A.R. acknowledges funding from the Swiss National Fund for Research (31003A_130520, 31003A_149975, and 31003A_173087) and the European Research Council Consolidator (311536). A.Š. acknowledges the European Research Council (802960). B.B. thanks the BBSRC (BB/K009001/1) and Wellcome Trust (203276/Z/16/Z) for support. J.M.v.F. acknowledges funding through an EMBO Long-Term Fellowship (ALTF 1065-2015), the European Commission FP7 (Marie Curie Actions, LTFCOFUND2013, and GA-2013-609409), and a Transitional Postdoc fellowship (2015/345) from the Swiss SystemsX.ch initiative, evaluated by the Swiss National Science Foundation and Swiss National Science Foundation Research (SNSF SINERGIA 160728/1 [leader, Sophie Martin]).","intvolume":" 182","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S0092867420309296"}],"title":"An ESCRT-III polymerization sequence drives membrane deformation and fission","keyword":["general biochemistry","genetics and molecular biology"],"volume":182,"date_created":"2021-11-26T08:02:27Z","abstract":[{"text":"The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes membrane fission from within membrane necks, a process that is essential for many cellular functions, from cell division to lysosome degradation and autophagy. How it breaks membranes, though, remains unknown. Here, we characterize a sequential polymerization of ESCRT-III subunits that, driven by a recruitment cascade and by continuous subunit-turnover powered by the ATPase Vps4, induces membrane deformation and fission. During this process, the exchange of Vps24 for Did2 induces a tilt in the polymer-membrane interface, which triggers transition from flat spiral polymers to helical filament to drive the formation of membrane protrusions, and ends with the formation of a highly constricted Did2-Ist1 co-polymer that we show is competent to promote fission when bound on the inside of membrane necks. Overall, our results suggest a mechanism of stepwise changes in ESCRT-III filament structure and mechanical properties via exchange of the filament subunits to catalyze ESCRT-III activity.","lang":"eng"}],"day":"18","scopus_import":"1","extern":"1","pmid":1,"issue":"5","year":"2020","status":"public","publication_identifier":{"issn":["0092-8674"]},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","oa_version":"Published Version","oa":1,"article_processing_charge":"No","publication_status":"published","date_updated":"2021-11-26T08:58:37Z","month":"08","article_type":"original","date_published":"2020-08-18T00:00:00Z","publisher":"Elsevier"}]