[{"scopus_import":"1","title":"Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes","quality_controlled":"1","file":[{"relation":"main_file","date_updated":"2020-11-19T11:22:33Z","date_created":"2020-11-19T11:22:33Z","access_level":"open_access","file_name":"2020_ImmunologyCellBio_Obeidy.pdf","success":1,"checksum":"c389477b4b52172ef76afff8a06c6775","file_size":8569945,"file_id":"8775","creator":"dernst","content_type":"application/pdf"}],"doi":"10.1111/imcb.12304","oa_version":"Published Version","external_id":{"isi":["000503885600001"],"pmid":["31698518"]},"file_date_updated":"2020-11-19T11:22:33Z","ddc":["570"],"pmid":1,"publication":"Immunology and Cell Biology","article_processing_charge":"No","date_published":"2020-02-01T00:00:00Z","publication_status":"published","department":[{"_id":"MiSi"}],"isi":1,"date_created":"2020-01-05T23:00:48Z","author":[{"last_name":"Obeidy","first_name":"Peyman","full_name":"Obeidy, Peyman"},{"full_name":"Ju, Lining A.","first_name":"Lining A.","last_name":"Ju"},{"full_name":"Oehlers, Stefan H.","last_name":"Oehlers","first_name":"Stefan H."},{"first_name":"Nursafwana S.","last_name":"Zulkhernain","full_name":"Zulkhernain, Nursafwana S."},{"full_name":"Lee, Quintin","first_name":"Quintin","last_name":"Lee"},{"full_name":"Galeano Niño, Jorge L.","last_name":"Galeano Niño","first_name":"Jorge L."},{"full_name":"Kwan, Rain Y.Q.","last_name":"Kwan","first_name":"Rain Y.Q."},{"full_name":"Tikoo, Shweta","last_name":"Tikoo","first_name":"Shweta"},{"first_name":"Lois L.","last_name":"Cavanagh","full_name":"Cavanagh, Lois L."},{"last_name":"Mrass","first_name":"Paulus","full_name":"Mrass, Paulus"},{"full_name":"Cook, Adam J.L.","first_name":"Adam J.L.","last_name":"Cook"},{"first_name":"Shaun P.","last_name":"Jackson","full_name":"Jackson, Shaun P."},{"last_name":"Biro","first_name":"Maté","full_name":"Biro, Maté"},{"last_name":"Roediger","first_name":"Ben","full_name":"Roediger, Ben"},{"last_name":"Sixt","first_name":"Michael K","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179"},{"full_name":"Weninger, Wolfgang","last_name":"Weninger","first_name":"Wolfgang"}],"intvolume":"        98","publication_identifier":{"issn":["0818-9641"],"eissn":["1440-1711"]},"year":"2020","status":"public","month":"02","issue":"2","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","citation":{"apa":"Obeidy, P., Ju, L. A., Oehlers, S. H., Zulkhernain, N. S., Lee, Q., Galeano Niño, J. L., … Weninger, W. (2020). Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes. <i>Immunology and Cell Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/imcb.12304\">https://doi.org/10.1111/imcb.12304</a>","chicago":"Obeidy, Peyman, Lining A. Ju, Stefan H. Oehlers, Nursafwana S. Zulkhernain, Quintin Lee, Jorge L. Galeano Niño, Rain Y.Q. Kwan, et al. “Partial Loss of Actin Nucleator Actin-Related Protein 2/3 Activity Triggers Blebbing in Primary T Lymphocytes.” <i>Immunology and Cell Biology</i>. Wiley, 2020. <a href=\"https://doi.org/10.1111/imcb.12304\">https://doi.org/10.1111/imcb.12304</a>.","ieee":"P. Obeidy <i>et al.</i>, “Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes,” <i>Immunology and Cell Biology</i>, vol. 98, no. 2. Wiley, pp. 93–113, 2020.","ista":"Obeidy P, Ju LA, Oehlers SH, Zulkhernain NS, Lee Q, Galeano Niño JL, Kwan RYQ, Tikoo S, Cavanagh LL, Mrass P, Cook AJL, Jackson SP, Biro M, Roediger B, Sixt MK, Weninger W. 2020. Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes. Immunology and Cell Biology. 98(2), 93–113.","mla":"Obeidy, Peyman, et al. “Partial Loss of Actin Nucleator Actin-Related Protein 2/3 Activity Triggers Blebbing in Primary T Lymphocytes.” <i>Immunology and Cell Biology</i>, vol. 98, no. 2, Wiley, 2020, pp. 93–113, doi:<a href=\"https://doi.org/10.1111/imcb.12304\">10.1111/imcb.12304</a>.","short":"P. Obeidy, L.A. Ju, S.H. Oehlers, N.S. Zulkhernain, Q. Lee, J.L. Galeano Niño, R.Y.Q. Kwan, S. Tikoo, L.L. Cavanagh, P. Mrass, A.J.L. Cook, S.P. Jackson, M. Biro, B. Roediger, M.K. Sixt, W. Weninger, Immunology and Cell Biology 98 (2020) 93–113.","ama":"Obeidy P, Ju LA, Oehlers SH, et al. Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes. <i>Immunology and Cell Biology</i>. 2020;98(2):93-113. doi:<a href=\"https://doi.org/10.1111/imcb.12304\">10.1111/imcb.12304</a>"},"date_updated":"2026-04-02T14:29:00Z","abstract":[{"text":"T lymphocytes utilize amoeboid migration to navigate effectively within complex microenvironments. The precise rearrangement of the actin cytoskeleton required for cellular forward propulsion is mediated by actin regulators, including the actin‐related protein 2/3 (Arp2/3) complex, a macromolecular machine that nucleates branched actin filaments at the leading edge. The consequences of modulating Arp2/3 activity on the biophysical properties of the actomyosin cortex and downstream T cell function are incompletely understood. We report that even a moderate decrease of Arp3 levels in T cells profoundly affects actin cortex integrity. Reduction in total F‐actin content leads to reduced cortical tension and disrupted lamellipodia formation. Instead, in Arp3‐knockdown cells, the motility mode is dominated by blebbing migration characterized by transient, balloon‐like protrusions at the leading edge. Although this migration mode seems to be compatible with interstitial migration in three‐dimensional environments, diminished locomotion kinetics and impaired cytotoxicity interfere with optimal T cell function. These findings define the importance of finely tuned, Arp2/3‐dependent mechanophysical membrane integrity in cytotoxic effector T lymphocyte activities.","lang":"eng"}],"language":[{"iso":"eng"}],"oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","type":"journal_article","volume":98,"page":"93-113","publisher":"Wiley","day":"01","_id":"7234","article_type":"original"},{"issue":"7","article_number":"107647","tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"has_accepted_license":"1","citation":{"apa":"Parenti, I., Diab, F., Gil, S. R., Mulugeta, E., Casa, V., Berutti, R., … Wendt, K. S. (2020). MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2020.107647\">https://doi.org/10.1016/j.celrep.2020.107647</a>","chicago":"Parenti, Ilaria, Farah Diab, Sara Ruiz Gil, Eskeatnaf Mulugeta, Valentina Casa, Riccardo Berutti, Rutger W.W. Brouwer, et al. “MAU2 and NIPBL Variants Impair the Heterodimerization of the Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome.” <i>Cell Reports</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.celrep.2020.107647\">https://doi.org/10.1016/j.celrep.2020.107647</a>.","ieee":"I. Parenti <i>et al.</i>, “MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome,” <i>Cell Reports</i>, vol. 31, no. 7. Elsevier, 2020.","ista":"Parenti I, Diab F, Gil SR, Mulugeta E, Casa V, Berutti R, Brouwer RWW, Dupé V, Eckhold J, Graf E, Puisac B, Ramos F, Schwarzmayr T, Gines MM, Van Staveren T, Van Ijcken WFJ, Strom TM, Pié J, Watrin E, Kaiser FJ, Wendt KS. 2020. MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome. Cell Reports. 31(7), 107647.","mla":"Parenti, Ilaria, et al. “MAU2 and NIPBL Variants Impair the Heterodimerization of the Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome.” <i>Cell Reports</i>, vol. 31, no. 7, 107647, Elsevier, 2020, doi:<a href=\"https://doi.org/10.1016/j.celrep.2020.107647\">10.1016/j.celrep.2020.107647</a>.","short":"I. Parenti, F. Diab, S.R. Gil, E. Mulugeta, V. Casa, R. Berutti, R.W.W. Brouwer, V. Dupé, J. Eckhold, E. Graf, B. Puisac, F. Ramos, T. Schwarzmayr, M.M. Gines, T. Van Staveren, W.F.J. Van Ijcken, T.M. Strom, J. Pié, E. Watrin, F.J. Kaiser, K.S. Wendt, Cell Reports 31 (2020).","ama":"Parenti I, Diab F, Gil SR, et al. MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome. <i>Cell Reports</i>. 2020;31(7). doi:<a href=\"https://doi.org/10.1016/j.celrep.2020.107647\">10.1016/j.celrep.2020.107647</a>"},"date_updated":"2026-04-02T14:28:04Z","abstract":[{"text":"The NIPBL/MAU2 heterodimer loads cohesin onto chromatin. Mutations inNIPBLaccount for most cases ofthe rare developmental disorder Cornelia de Lange syndrome (CdLS). Here we report aMAU2 variant causing CdLS, a deletion of seven amino acids that impairs the interaction between MAU2 and the NIPBL N terminus.Investigating this interaction, we discovered that MAU2 and the NIPBL N terminus are largely dispensable fornormal cohesin and NIPBL function in cells with a NIPBL early truncating mutation. Despite a predicted fataloutcome of an out-of-frame single nucleotide duplication inNIPBL, engineered in two different cell lines,alternative translation initiation yields a form of NIPBL missing N-terminal residues. This form cannot interactwith MAU2, but binds DNA and mediates cohesin loading. Altogether, our work reveals that cohesin loading can occur independently of functional NIPBL/MAU2 complexes and highlights a novel mechanism protectiveagainst out-of-frame mutations that is potentially relevant for other genetic conditions.","lang":"eng"}],"language":[{"iso":"eng"}],"oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","volume":31,"type":"journal_article","day":"19","publisher":"Elsevier","_id":"7877","article_type":"original","scopus_import":"1","title":"MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome","quality_controlled":"1","file":[{"relation":"main_file","access_level":"open_access","file_name":"2020_CellReports_Parenti.pdf","date_created":"2020-05-26T11:05:01Z","date_updated":"2020-07-14T12:48:04Z","file_id":"7892","content_type":"application/pdf","creator":"dernst","checksum":"64d8f7467731ee5c166b10b939b8310b","file_size":4695682}],"file_date_updated":"2020-07-14T12:48:04Z","oa_version":"Published Version","external_id":{"isi":["000535655200005"]},"doi":"10.1016/j.celrep.2020.107647","ddc":["570"],"publication":"Cell Reports","article_processing_charge":"No","date_published":"2020-05-19T00:00:00Z","publication_status":"published","department":[{"_id":"GaNo"}],"date_created":"2020-05-24T22:00:57Z","isi":1,"author":[{"id":"D93538B0-5B71-11E9-AC62-02EBE5697425","full_name":"Parenti, Ilaria","last_name":"Parenti","first_name":"Ilaria"},{"last_name":"Diab","first_name":"Farah","full_name":"Diab, Farah"},{"last_name":"Gil","first_name":"Sara Ruiz","full_name":"Gil, Sara Ruiz"},{"full_name":"Mulugeta, Eskeatnaf","first_name":"Eskeatnaf","last_name":"Mulugeta"},{"last_name":"Casa","first_name":"Valentina","full_name":"Casa, Valentina"},{"full_name":"Berutti, Riccardo","first_name":"Riccardo","last_name":"Berutti"},{"full_name":"Brouwer, Rutger W.W.","first_name":"Rutger W.W.","last_name":"Brouwer"},{"full_name":"Dupé, Valerie","first_name":"Valerie","last_name":"Dupé"},{"last_name":"Eckhold","first_name":"Juliane","full_name":"Eckhold, Juliane"},{"full_name":"Graf, Elisabeth","first_name":"Elisabeth","last_name":"Graf"},{"last_name":"Puisac","first_name":"Beatriz","full_name":"Puisac, Beatriz"},{"last_name":"Ramos","first_name":"Feliciano","full_name":"Ramos, Feliciano"},{"full_name":"Schwarzmayr, Thomas","last_name":"Schwarzmayr","first_name":"Thomas"},{"last_name":"Gines","first_name":"Macarena Moronta","full_name":"Gines, Macarena Moronta"},{"full_name":"Van Staveren, Thomas","last_name":"Van Staveren","first_name":"Thomas"},{"full_name":"Van Ijcken, Wilfred F.J.","last_name":"Van Ijcken","first_name":"Wilfred F.J."},{"full_name":"Strom, Tim M.","first_name":"Tim M.","last_name":"Strom"},{"first_name":"Juan","last_name":"Pié","full_name":"Pié, Juan"},{"full_name":"Watrin, Erwan","last_name":"Watrin","first_name":"Erwan"},{"full_name":"Kaiser, Frank J.","first_name":"Frank J.","last_name":"Kaiser"},{"last_name":"Wendt","first_name":"Kerstin S.","full_name":"Wendt, Kerstin S."}],"intvolume":"        31","publication_identifier":{"eissn":["2211-1247"]},"year":"2020","status":"public","month":"05"},{"_id":"7878","article_type":"original","day":"13","publisher":"eLife Sciences Publications","citation":{"ieee":"J. Bao <i>et al.</i>, “Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020.","chicago":"Bao, Jin, Michael Graupner, Guadalupe Astorga, Thibault Collin, Abdelali Jalil, Dwi Wahyu Indriati, Jonathan Bradley, Ryuichi Shigemoto, and Isabel Llano. “Synergism of Type 1 Metabotropic and Ionotropic Glutamate Receptors in Cerebellar Molecular Layer Interneurons in Vivo.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/eLife.56839\">https://doi.org/10.7554/eLife.56839</a>.","apa":"Bao, J., Graupner, M., Astorga, G., Collin, T., Jalil, A., Indriati, D. W., … Llano, I. (2020). Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.56839\">https://doi.org/10.7554/eLife.56839</a>","ista":"Bao J, Graupner M, Astorga G, Collin T, Jalil A, Indriati DW, Bradley J, Shigemoto R, Llano I. 2020. Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo. eLife. 9, e56839.","mla":"Bao, Jin, et al. “Synergism of Type 1 Metabotropic and Ionotropic Glutamate Receptors in Cerebellar Molecular Layer Interneurons in Vivo.” <i>ELife</i>, vol. 9, e56839, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/eLife.56839\">10.7554/eLife.56839</a>.","ama":"Bao J, Graupner M, Astorga G, et al. Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/eLife.56839\">10.7554/eLife.56839</a>","short":"J. Bao, M. Graupner, G. Astorga, T. Collin, A. Jalil, D.W. Indriati, J. Bradley, R. Shigemoto, I. Llano, ELife 9 (2020)."},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","article_number":"e56839","type":"journal_article","volume":9,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"language":[{"iso":"eng"}],"abstract":[{"text":"Type 1 metabotropic glutamate receptors (mGluR1s) are key elements in neuronal signaling. While their function is well documented in slices, requirements for their activation in vivo are poorly understood. We examine this question in adult mice in vivo using 2-photon imaging of cerebellar molecular layer interneurons (MLIs) expressing GCaMP. In anesthetized mice, parallel fiber activation evokes beam-like Cai rises in postsynaptic MLIs which depend on co-activation of mGluR1s and ionotropic glutamate receptors (iGluRs). In awake mice, blocking mGluR1 decreases Cai rises associated with locomotion. In vitro studies and freeze-fracture electron microscopy show that the iGluR-mGluR1 interaction is synergistic and favored by close association of the two classes of receptors. Altogether our results suggest that mGluR1s, acting in synergy with iGluRs, potently contribute to processing cerebellar neuronal signaling under physiological conditions.","lang":"eng"}],"date_updated":"2026-04-02T14:28:17Z","department":[{"_id":"RySh"}],"publication_status":"published","date_published":"2020-05-13T00:00:00Z","month":"05","status":"public","year":"2020","publication_identifier":{"eissn":["2050-084X"]},"intvolume":"         9","author":[{"full_name":"Bao, Jin","first_name":"Jin","last_name":"Bao"},{"first_name":"Michael","last_name":"Graupner","full_name":"Graupner, Michael"},{"full_name":"Astorga, Guadalupe","first_name":"Guadalupe","last_name":"Astorga"},{"first_name":"Thibault","last_name":"Collin","full_name":"Collin, Thibault"},{"full_name":"Jalil, Abdelali","last_name":"Jalil","first_name":"Abdelali"},{"full_name":"Indriati, Dwi Wahyu","last_name":"Indriati","first_name":"Dwi Wahyu"},{"last_name":"Bradley","first_name":"Jonathan","full_name":"Bradley, Jonathan"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","last_name":"Shigemoto"},{"full_name":"Llano, Isabel","last_name":"Llano","first_name":"Isabel"}],"isi":1,"date_created":"2020-05-24T22:00:58Z","ddc":["570"],"external_id":{"pmid":["32401196"],"isi":["000535191600001"]},"doi":"10.7554/eLife.56839","file_date_updated":"2020-07-14T12:48:04Z","oa_version":"Published Version","file":[{"relation":"main_file","date_created":"2020-05-26T09:34:54Z","date_updated":"2020-07-14T12:48:04Z","access_level":"open_access","file_name":"2020_eLife_Bao.pdf","checksum":"8ea99bb6660cc407dbdb00c173b01683","file_size":4832050,"file_id":"7891","content_type":"application/pdf","creator":"dernst"}],"quality_controlled":"1","title":"Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo","scopus_import":"1","article_processing_charge":"No","pmid":1,"publication":"eLife"},{"type":"journal_article","volume":20,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"language":[{"iso":"eng"}],"abstract":[{"text":"Wood, as the most abundant carbon dioxide storing bioresource, is currently driven beyond its traditional use through creative innovations and nanotechnology. For many properties the micro- and nanostructure plays a crucial role and one key challenge is control and detection of chemical and physical processes in the confined microstructure and nanopores of the wooden cell wall. In this study, correlative Raman and atomic force microscopy show high potential for tracking in situ molecular rearrangement of wood polymers during compression. More water molecules (interpreted as wider cellulose microfibril distances) and disentangling of hemicellulose chains are detected in the opened cell wall regions, whereas an increase of lignin is revealed in the compressed areas. These results support a new more “loose” cell wall model based on flexible lignin nanodomains and advance our knowledge of the molecular reorganization during deformation of wood for optimized processing and utilization.","lang":"eng"}],"date_updated":"2026-04-02T14:26:44Z","citation":{"mla":"Felhofer, Martin, et al. “Wood Deformation Leads to Rearrangement of Molecules at the Nanoscale.” <i>Nano Letters</i>, vol. 20, no. 4, American Chemical Society, 2020, pp. 2647–53, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.0c00205\">10.1021/acs.nanolett.0c00205</a>.","ama":"Felhofer M, Bock P, Singh A, Prats Mateu B, Zirbs R, Gierlinger N. Wood deformation leads to rearrangement of molecules at the nanoscale. <i>Nano Letters</i>. 2020;20(4):2647-2653. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.0c00205\">10.1021/acs.nanolett.0c00205</a>","short":"M. Felhofer, P. Bock, A. Singh, B. Prats Mateu, R. Zirbs, N. Gierlinger, Nano Letters 20 (2020) 2647–2653.","chicago":"Felhofer, Martin, Peter Bock, Adya Singh, Batirtze Prats Mateu, Ronald Zirbs, and Notburga Gierlinger. “Wood Deformation Leads to Rearrangement of Molecules at the Nanoscale.” <i>Nano Letters</i>. American Chemical Society, 2020. <a href=\"https://doi.org/10.1021/acs.nanolett.0c00205\">https://doi.org/10.1021/acs.nanolett.0c00205</a>.","ieee":"M. Felhofer, P. Bock, A. Singh, B. Prats Mateu, R. Zirbs, and N. Gierlinger, “Wood deformation leads to rearrangement of molecules at the nanoscale,” <i>Nano Letters</i>, vol. 20, no. 4. American Chemical Society, pp. 2647–2653, 2020.","apa":"Felhofer, M., Bock, P., Singh, A., Prats Mateu, B., Zirbs, R., &#38; Gierlinger, N. (2020). Wood deformation leads to rearrangement of molecules at the nanoscale. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.0c00205\">https://doi.org/10.1021/acs.nanolett.0c00205</a>","ista":"Felhofer M, Bock P, Singh A, Prats Mateu B, Zirbs R, Gierlinger N. 2020. Wood deformation leads to rearrangement of molecules at the nanoscale. Nano Letters. 20(4), 2647–2653."},"has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"issue":"4","_id":"7663","article_type":"original","publisher":"American Chemical Society","day":"08","page":"2647-2653","article_processing_charge":"No","publication":"Nano Letters","pmid":1,"ddc":["530"],"oa_version":"Published Version","doi":"10.1021/acs.nanolett.0c00205","file_date_updated":"2020-07-14T12:48:01Z","external_id":{"pmid":["32196350"],"isi":["000526413400055"]},"file":[{"file_id":"7667","content_type":"application/pdf","creator":"dernst","checksum":"fe46146a9c4c620592a1932a8599069e","file_size":7108014,"access_level":"open_access","file_name":"2020_NanoLetters_Felhofer.pdf","date_created":"2020-04-20T10:43:36Z","date_updated":"2020-07-14T12:48:01Z","relation":"main_file"}],"quality_controlled":"1","title":"Wood deformation leads to rearrangement of molecules at the nanoscale","scopus_import":"1","month":"04","status":"public","year":"2020","intvolume":"        20","publication_identifier":{"eissn":["1530-6992"]},"author":[{"last_name":"Felhofer","first_name":"Martin","full_name":"Felhofer, Martin"},{"first_name":"Peter","last_name":"Bock","full_name":"Bock, Peter"},{"full_name":"Singh, Adya","first_name":"Adya","last_name":"Singh"},{"first_name":"Batirtze","last_name":"Prats Mateu","id":"299FE892-F248-11E8-B48F-1D18A9856A87","full_name":"Prats Mateu, Batirtze"},{"first_name":"Ronald","last_name":"Zirbs","full_name":"Zirbs, Ronald"},{"first_name":"Notburga","last_name":"Gierlinger","full_name":"Gierlinger, Notburga"}],"date_created":"2020-04-19T22:00:54Z","isi":1,"department":[{"_id":"MaLo"}],"publication_status":"published","date_published":"2020-04-08T00:00:00Z"},{"title":"Cu homeostasis in bacteria: The ins and outs","quality_controlled":"1","scopus_import":"1","doi":"10.3390/membranes10090242","file_date_updated":"2020-09-28T11:36:50Z","oa_version":"Published Version","external_id":{"isi":["000581446000001"]},"ddc":["570"],"file":[{"date_created":"2020-09-28T11:36:50Z","date_updated":"2020-09-28T11:36:50Z","access_level":"open_access","file_name":"2020_Membranes_Andrei.pdf","success":1,"checksum":"ceb43d7554e712dea6f36f9287271737","file_size":4612258,"content_type":"application/pdf","creator":"dernst","file_id":"8583","relation":"main_file"}],"publication":"Membranes","article_processing_charge":"No","date_published":"2020-09-01T00:00:00Z","department":[{"_id":"LeSa"}],"publication_status":"published","author":[{"first_name":"Andreea","last_name":"Andrei","full_name":"Andrei, Andreea"},{"full_name":"Öztürk, Yavuz","last_name":"Öztürk","first_name":"Yavuz"},{"full_name":"Khalfaoui-Hassani, Bahia","first_name":"Bahia","last_name":"Khalfaoui-Hassani"},{"last_name":"Rauch","first_name":"Juna","full_name":"Rauch, Juna"},{"first_name":"Dorian","last_name":"Marckmann","full_name":"Marckmann, Dorian"},{"first_name":"Petru Iulian","last_name":"Trasnea","id":"D560034C-10C4-11EA-ABF4-A4B43DDC885E","full_name":"Trasnea, Petru Iulian"},{"first_name":"Fevzi","last_name":"Daldal","full_name":"Daldal, Fevzi"},{"last_name":"Koch","first_name":"Hans-Georg","full_name":"Koch, Hans-Georg"}],"publication_identifier":{"eissn":["2077-0375"]},"intvolume":"        10","date_created":"2020-09-28T08:59:26Z","isi":1,"status":"public","month":"09","year":"2020","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","issue":"9","article_number":"242","citation":{"ama":"Andrei A, Öztürk Y, Khalfaoui-Hassani B, et al. Cu homeostasis in bacteria: The ins and outs. <i>Membranes</i>. 2020;10(9). doi:<a href=\"https://doi.org/10.3390/membranes10090242\">10.3390/membranes10090242</a>","short":"A. Andrei, Y. Öztürk, B. Khalfaoui-Hassani, J. Rauch, D. Marckmann, P.I. Trasnea, F. Daldal, H.-G. Koch, Membranes 10 (2020).","mla":"Andrei, Andreea, et al. “Cu Homeostasis in Bacteria: The Ins and Outs.” <i>Membranes</i>, vol. 10, no. 9, 242, MDPI, 2020, doi:<a href=\"https://doi.org/10.3390/membranes10090242\">10.3390/membranes10090242</a>.","ista":"Andrei A, Öztürk Y, Khalfaoui-Hassani B, Rauch J, Marckmann D, Trasnea PI, Daldal F, Koch H-G. 2020. Cu homeostasis in bacteria: The ins and outs. Membranes. 10(9), 242.","ieee":"A. Andrei <i>et al.</i>, “Cu homeostasis in bacteria: The ins and outs,” <i>Membranes</i>, vol. 10, no. 9. MDPI, 2020.","chicago":"Andrei, Andreea, Yavuz Öztürk, Bahia Khalfaoui-Hassani, Juna Rauch, Dorian Marckmann, Petru Iulian Trasnea, Fevzi Daldal, and Hans-Georg Koch. “Cu Homeostasis in Bacteria: The Ins and Outs.” <i>Membranes</i>. MDPI, 2020. <a href=\"https://doi.org/10.3390/membranes10090242\">https://doi.org/10.3390/membranes10090242</a>.","apa":"Andrei, A., Öztürk, Y., Khalfaoui-Hassani, B., Rauch, J., Marckmann, D., Trasnea, P. I., … Koch, H.-G. (2020). Cu homeostasis in bacteria: The ins and outs. <i>Membranes</i>. MDPI. <a href=\"https://doi.org/10.3390/membranes10090242\">https://doi.org/10.3390/membranes10090242</a>"},"abstract":[{"text":"Copper (Cu) is an essential trace element for all living organisms and used as cofactor in key enzymes of important biological processes, such as aerobic respiration or superoxide dismutation. However, due to its toxicity, cells have developed elaborate mechanisms for Cu homeostasis, which balance Cu supply for cuproprotein biogenesis with the need to remove excess Cu. This review summarizes our current knowledge on bacterial Cu homeostasis with a focus on Gram-negative bacteria and describes the multiple strategies that bacteria use for uptake, storage and export of Cu. We furthermore describe general mechanistic principles that aid the bacterial response to toxic Cu concentrations and illustrate dedicated Cu relay systems that facilitate Cu delivery for cuproenzyme biogenesis. Progress in understanding how bacteria avoid Cu poisoning while maintaining a certain Cu quota for cell proliferation is of particular importance for microbial pathogens because Cu is utilized by the host immune system for attenuating pathogen survival in host cells.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2026-04-02T14:29:28Z","volume":10,"type":"journal_article","oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publisher":"MDPI","day":"01","article_type":"original","_id":"8579"},{"article_type":"original","_id":"8597","day":"23","publisher":"IOP Publishing","oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","volume":17,"type":"journal_article","date_updated":"2026-04-02T14:29:42Z","abstract":[{"lang":"eng","text":"Error analysis and data visualization of positive COVID-19 cases in 27 countries have been performed up to August 8, 2020. This survey generally observes a progression from early exponential growth transitioning to an intermediate power-law growth phase, as recently suggested by Ziff and Ziff. The occurrence of logistic growth after the power-law phase with lockdowns or social distancing may be described as an effect of avoidance. A visualization of the power-law growth exponent over short time windows is qualitatively similar to the Bhatia visualization for pandemic progression. Visualizations like these can indicate the onset of second waves and may influence social policy."}],"language":[{"iso":"eng"}],"citation":{"chicago":"Merrin, Jack. “Differences in Power Law Growth over Time and Indicators of COVID-19 Pandemic Progression Worldwide.” <i>Physical Biology</i>. IOP Publishing, 2020. <a href=\"https://doi.org/10.1088/1478-3975/abb2db\">https://doi.org/10.1088/1478-3975/abb2db</a>.","ieee":"J. Merrin, “Differences in power law growth over time and indicators of COVID-19 pandemic progression worldwide,” <i>Physical Biology</i>, vol. 17, no. 6. IOP Publishing, 2020.","apa":"Merrin, J. (2020). Differences in power law growth over time and indicators of COVID-19 pandemic progression worldwide. <i>Physical Biology</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1478-3975/abb2db\">https://doi.org/10.1088/1478-3975/abb2db</a>","ista":"Merrin J. 2020. Differences in power law growth over time and indicators of COVID-19 pandemic progression worldwide. Physical Biology. 17(6), 065005.","mla":"Merrin, Jack. “Differences in Power Law Growth over Time and Indicators of COVID-19 Pandemic Progression Worldwide.” <i>Physical Biology</i>, vol. 17, no. 6, 065005, IOP Publishing, 2020, doi:<a href=\"https://doi.org/10.1088/1478-3975/abb2db\">10.1088/1478-3975/abb2db</a>.","ama":"Merrin J. Differences in power law growth over time and indicators of COVID-19 pandemic progression worldwide. <i>Physical Biology</i>. 2020;17(6). doi:<a href=\"https://doi.org/10.1088/1478-3975/abb2db\">10.1088/1478-3975/abb2db</a>","short":"J. Merrin, Physical Biology 17 (2020)."},"issue":"6","article_number":"065005","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","year":"2020","status":"public","month":"09","isi":1,"date_created":"2020-10-04T22:01:35Z","author":[{"last_name":"Merrin","first_name":"Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack","orcid":"0000-0001-5145-4609"}],"intvolume":"        17","publication_identifier":{"eissn":["1478-3975"]},"publication_status":"published","department":[{"_id":"NanoFab"}],"corr_author":"1","date_published":"2020-09-23T00:00:00Z","article_processing_charge":"Yes (via OA deal)","acknowledgement":"I would especially like to thank Michael Sixt for encouraging me to think about these problems while working at home due to restrictions in place. I want to thank Nick Barton, Katka Bodova, Matthew Robinson, Simon Rella, Federico Sau, Ivan Prieto, and Pradeep Kumar for useful discussions.","publication":"Physical Biology","file":[{"relation":"main_file","content_type":"application/pdf","creator":"dernst","file_id":"8609","file_size":1667111,"checksum":"fec9bdd355ed349f09990faab20838a7","success":1,"file_name":"2020_PhysBio_Merrin.pdf","access_level":"open_access","date_updated":"2020-10-05T13:53:59Z","date_created":"2020-10-05T13:53:59Z"}],"file_date_updated":"2020-10-05T13:53:59Z","external_id":{"isi":["000575539700001"]},"doi":"10.1088/1478-3975/abb2db","oa_version":"Published Version","ddc":["510","570"],"scopus_import":"1","title":"Differences in power law growth over time and indicators of COVID-19 pandemic progression worldwide","quality_controlled":"1"},{"abstract":[{"lang":"eng","text":"Additional file 2: Supplementary Tables. The association of pre-adjusted protein levels with biological and technical covariates. Protein levels were adjusted for age, sex, array plate and four genetic principal components (population structure) prior to analyses. Significant associations are emboldened. (Table S1). pQTLs associated with inflammatory biomarker levels from Bayesian penalised regression model (Posterior Inclusion Probability > 95%). (Table S2). All pQTLs associated with inflammatory biomarker levels from ordinary least squares regression model (P < 7.14 × 10− 10). (Table S3). Summary of lambda values relating to ordinary least squares GWAS and EWAS performed on inflammatory protein levels (n = 70) in Lothian Birth Cohort 1936 study. (Table S4). Conditionally significant pQTLs associated with inflammatory biomarker levels from ordinary least squares regression model (P < 7.14 × 10− 10). (Table S5). Comparison of variance explained by ordinary least squares and Bayesian penalised regression models for concordantly identified SNPs. (Table S6). Estimate of heritability for blood protein levels as well as proportion of variance explained attributable to different prior mixtures. (Table S7). Comparison of heritability estimates from Ahsan et al. (maximum likelihood) and Hillary et al. (Bayesian penalised regression). (Table S8). List of concordant SNPs identified by linear model and Bayesian penalised regression and whether they have been previously identified as eQTLs. (Table S9). Bayesian tests of colocalisation for cis pQTLs and cis eQTLs. (Table S10). Sherlock algorithm: Genes whose expression are putatively associated with circulating inflammatory proteins that harbour pQTLs. (Table S11). CpGs associated with inflammatory protein biomarkers as identified by Bayesian model (Bayesian model; Posterior Inclusion Probability > 95%). (Table S12). CpGs associated with inflammatory protein biomarkers as identified by linear model (limma) at P < 5.14 × 10− 10. (Table S13). CpGs associated with inflammatory protein biomarkers as identified by mixed linear model (OSCA) at P < 5.14 × 10− 10. (Table S14). Estimate of variance explained for blood protein levels by DNA methylation as well as proportion of explained attributable to different prior mixtures - BayesR+. (Table S15). Comparison of variance in protein levels explained by genome-wide DNA methylation data by mixed linear model (OSCA) and Bayesian penalised regression model (BayesR+). (Table S16). Variance in circulating inflammatory protein biomarker levels explained by common genetic and methylation data (joint and conditional estimates from BayesR+). Ordered by combined variance explained by genetic and epigenetic data - smallest to largest. Significant results from t-tests comparing distributions for variance explained by methylation or genetics alone versus combined estimate are emboldened. (Table S17). Genetic and epigenetic factors identified by BayesR+ when conditioning on all SNPs and CpGs together. (Table S18). Mendelian Randomisation analyses to assess whether proteins with concordantly identified genetic signals are causally associated with Alzheimer’s disease risk. (Table S19)."}],"other_data_license":"CC0 + CC BY (4.0)","date_updated":"2026-04-02T14:28:32Z","type":"research_data_reference","article_processing_charge":"No","oa":1,"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults","oa_version":"Published Version","doi":"10.6084/m9.figshare.12629697.v1","citation":{"chicago":"Hillary, Robert F., Daniel Trejo-Banos, Athanasios Kousathanas, Daniel L. McCartney, Sarah E. Harris, Anna J. Stevenson, Marion Patxot, et al. “Additional File 2 of Multi-Method Genome- and Epigenome-Wide Studies of Inflammatory Protein Levels in Healthy Older Adults.” Springer Nature, 2020. <a href=\"https://doi.org/10.6084/m9.figshare.12629697.v1\">https://doi.org/10.6084/m9.figshare.12629697.v1</a>.","ieee":"R. F. Hillary <i>et al.</i>, “Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults.” Springer Nature, 2020.","apa":"Hillary, R. F., Trejo-Banos, D., Kousathanas, A., McCartney, D. L., Harris, S. E., Stevenson, A. J., … Marioni, R. E. (2020). Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. Springer Nature. <a href=\"https://doi.org/10.6084/m9.figshare.12629697.v1\">https://doi.org/10.6084/m9.figshare.12629697.v1</a>","ista":"Hillary RF, Trejo-Banos D, Kousathanas A, McCartney DL, Harris SE, Stevenson AJ, Patxot M, Ojavee SE, Zhang Q, Liewald DC, Ritchie CW, Evans KL, Tucker-Drob EM, Wray NR, McRae AF, Visscher PM, Deary IJ, Robinson MR, Marioni RE. 2020. Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults, Springer Nature, <a href=\"https://doi.org/10.6084/m9.figshare.12629697.v1\">10.6084/m9.figshare.12629697.v1</a>.","mla":"Hillary, Robert F., et al. <i>Additional File 2 of Multi-Method Genome- and Epigenome-Wide Studies of Inflammatory Protein Levels in Healthy Older Adults</i>. Springer Nature, 2020, doi:<a href=\"https://doi.org/10.6084/m9.figshare.12629697.v1\">10.6084/m9.figshare.12629697.v1</a>.","ama":"Hillary RF, Trejo-Banos D, Kousathanas A, et al. Additional file 2 of multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. 2020. doi:<a href=\"https://doi.org/10.6084/m9.figshare.12629697.v1\">10.6084/m9.figshare.12629697.v1</a>","short":"R.F. Hillary, D. Trejo-Banos, A. Kousathanas, D.L. McCartney, S.E. Harris, A.J. Stevenson, M. Patxot, S.E. Ojavee, Q. Zhang, D.C. Liewald, C.W. Ritchie, K.L. Evans, E.M. Tucker-Drob, N.R. Wray, A.F. McRae, P.M. Visscher, I.J. Deary, M.R. Robinson, R.E. Marioni, (2020)."},"author":[{"first_name":"Robert F.","last_name":"Hillary","full_name":"Hillary, Robert F."},{"first_name":"Daniel","last_name":"Trejo-Banos","full_name":"Trejo-Banos, Daniel"},{"full_name":"Kousathanas, Athanasios","last_name":"Kousathanas","first_name":"Athanasios"},{"last_name":"McCartney","first_name":"Daniel L.","full_name":"McCartney, Daniel L."},{"first_name":"Sarah E.","last_name":"Harris","full_name":"Harris, Sarah E."},{"first_name":"Anna J.","last_name":"Stevenson","full_name":"Stevenson, Anna J."},{"last_name":"Patxot","first_name":"Marion","full_name":"Patxot, Marion"},{"first_name":"Sven Erik","last_name":"Ojavee","full_name":"Ojavee, Sven Erik"},{"first_name":"Qian","last_name":"Zhang","full_name":"Zhang, Qian"},{"full_name":"Liewald, David C.","first_name":"David C.","last_name":"Liewald"},{"full_name":"Ritchie, Craig W.","first_name":"Craig W.","last_name":"Ritchie"},{"full_name":"Evans, Kathryn L.","last_name":"Evans","first_name":"Kathryn L."},{"full_name":"Tucker-Drob, Elliot M.","first_name":"Elliot M.","last_name":"Tucker-Drob"},{"last_name":"Wray","first_name":"Naomi R.","full_name":"Wray, Naomi R."},{"first_name":"Allan F. ","last_name":"McRae","full_name":"McRae, Allan F. "},{"full_name":"Visscher, Peter M.","last_name":"Visscher","first_name":"Peter M."},{"full_name":"Deary, Ian J.","last_name":"Deary","first_name":"Ian J."},{"full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","orcid":"0000-0001-8982-8813","last_name":"Robinson","first_name":"Matthew Richard"},{"full_name":"Marioni, Riccardo E. ","last_name":"Marioni","first_name":"Riccardo E. "}],"related_material":{"record":[{"id":"8133","status":"public","relation":"used_in_publication"}]},"date_created":"2021-07-23T08:59:15Z","day":"09","publisher":"Springer Nature","status":"public","month":"07","_id":"9706","year":"2020","date_published":"2020-07-09T00:00:00Z","main_file_link":[{"url":"https://doi.org/10.6084/m9.figshare.12629697.v1","open_access":"1"}],"department":[{"_id":"MaRo"}]},{"publisher":"Springer Nature","day":"01","_id":"7805","article_type":"original","article_number":"2170","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"ista":"Hurny A, Cuesta C, Cavallari N, Ötvös K, Duclercq J, Dokládal L, Montesinos López JC, Gallemi M, Semerádová H, Rauter T, Stenzel I, Persiau G, Benade F, Bhalearo R, Sýkorová E, Gorzsás A, Sechet J, Mouille G, Heilmann I, De Jaeger G, Ludwig-Müller J, Benková E. 2020. Synergistic on Auxin and Cytokinin 1 positively regulates growth and attenuates soil pathogen resistance. Nature Communications. 11, 2170.","chicago":"Hurny, Andrej, Candela Cuesta, Nicola Cavallari, Krisztina Ötvös, Jerome Duclercq, Ladislav Dokládal, Juan C Montesinos López, et al. “Synergistic on Auxin and Cytokinin 1 Positively Regulates Growth and Attenuates Soil Pathogen Resistance.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-15895-5\">https://doi.org/10.1038/s41467-020-15895-5</a>.","ieee":"A. Hurny <i>et al.</i>, “Synergistic on Auxin and Cytokinin 1 positively regulates growth and attenuates soil pathogen resistance,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","apa":"Hurny, A., Cuesta, C., Cavallari, N., Ötvös, K., Duclercq, J., Dokládal, L., … Benková, E. (2020). Synergistic on Auxin and Cytokinin 1 positively regulates growth and attenuates soil pathogen resistance. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-15895-5\">https://doi.org/10.1038/s41467-020-15895-5</a>","ama":"Hurny A, Cuesta C, Cavallari N, et al. Synergistic on Auxin and Cytokinin 1 positively regulates growth and attenuates soil pathogen resistance. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-15895-5\">10.1038/s41467-020-15895-5</a>","short":"A. Hurny, C. Cuesta, N. Cavallari, K. Ötvös, J. Duclercq, L. Dokládal, J.C. Montesinos López, M. Gallemi, H. Semerádová, T. Rauter, I. Stenzel, G. Persiau, F. Benade, R. Bhalearo, E. Sýkorová, A. Gorzsás, J. Sechet, G. Mouille, I. Heilmann, G. De Jaeger, J. Ludwig-Müller, E. Benková, Nature Communications 11 (2020).","mla":"Hurny, Andrej, et al. “Synergistic on Auxin and Cytokinin 1 Positively Regulates Growth and Attenuates Soil Pathogen Resistance.” <i>Nature Communications</i>, vol. 11, 2170, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-15895-5\">10.1038/s41467-020-15895-5</a>."},"date_updated":"2026-04-02T14:32:53Z","abstract":[{"text":"Plants as non-mobile organisms constantly integrate varying environmental signals to flexibly adapt their growth and development. Local fluctuations in water and nutrient availability, sudden changes in temperature or other abiotic and biotic stresses can trigger changes in the growth of plant organs. Multiple mutually interconnected hormonal signaling cascades act as essential endogenous translators of these exogenous signals in the adaptive responses of plants. Although the molecular backbones of hormone transduction pathways have been identified, the mechanisms underlying their interactions are largely unknown. Here, using genome wide transcriptome profiling we identify an auxin and cytokinin cross-talk component; SYNERGISTIC ON AUXIN AND CYTOKININ 1 (SYAC1), whose expression in roots is strictly dependent on both of these hormonal pathways. We show that SYAC1 is a regulator of secretory pathway, whose enhanced activity interferes with deposition of cell wall components and can fine-tune organ growth and sensitivity to soil pathogens.","lang":"eng"}],"language":[{"iso":"eng"}],"oa":1,"project":[{"grant_number":"I 1774-B16","_id":"2542D156-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Hormone cross-talk drives nutrient dependent plant development"},{"call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","volume":11,"type":"journal_article","corr_author":"1","ec_funded":1,"date_published":"2020-05-01T00:00:00Z","publication_status":"published","department":[{"_id":"EvBe"}],"isi":1,"date_created":"2020-05-10T22:00:48Z","author":[{"first_name":"Andrej","last_name":"Hurny","orcid":"0000-0003-3638-1426","id":"4DC4AF46-F248-11E8-B48F-1D18A9856A87","full_name":"Hurny, Andrej"},{"orcid":"0000-0003-1923-2410","id":"33A3C818-F248-11E8-B48F-1D18A9856A87","full_name":"Cuesta, Candela","first_name":"Candela","last_name":"Cuesta"},{"full_name":"Cavallari, Nicola","id":"457160E6-F248-11E8-B48F-1D18A9856A87","first_name":"Nicola","last_name":"Cavallari"},{"full_name":"Ötvös, Krisztina","id":"29B901B0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5503-4983","last_name":"Ötvös","first_name":"Krisztina"},{"first_name":"Jerome","last_name":"Duclercq","full_name":"Duclercq, Jerome"},{"full_name":"Dokládal, Ladislav","last_name":"Dokládal","first_name":"Ladislav"},{"orcid":"0000-0001-9179-6099","id":"310A8E3E-F248-11E8-B48F-1D18A9856A87","full_name":"Montesinos López, Juan C","first_name":"Juan C","last_name":"Montesinos López"},{"first_name":"Marçal","last_name":"Gallemi","orcid":"0000-0003-4675-6893","full_name":"Gallemi, Marçal","id":"460C6802-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Hana","last_name":"Semeradova","full_name":"Semeradova, Hana","id":"42FE702E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Rauter, Thomas","id":"A0385D1A-9376-11EA-A47D-9862C5E3AB22","first_name":"Thomas","last_name":"Rauter"},{"full_name":"Stenzel, Irene","last_name":"Stenzel","first_name":"Irene"},{"full_name":"Persiau, Geert","last_name":"Persiau","first_name":"Geert"},{"full_name":"Benade, Freia","first_name":"Freia","last_name":"Benade"},{"first_name":"Rishikesh","last_name":"Bhalearo","full_name":"Bhalearo, Rishikesh"},{"full_name":"Sýkorová, Eva","first_name":"Eva","last_name":"Sýkorová"},{"last_name":"Gorzsás","first_name":"András","full_name":"Gorzsás, András"},{"last_name":"Sechet","first_name":"Julien","full_name":"Sechet, Julien"},{"full_name":"Mouille, Gregory","last_name":"Mouille","first_name":"Gregory"},{"first_name":"Ingo","last_name":"Heilmann","full_name":"Heilmann, Ingo"},{"first_name":"Geert","last_name":"De Jaeger","full_name":"De Jaeger, Geert"},{"first_name":"Jutta","last_name":"Ludwig-Müller","full_name":"Ludwig-Müller, Jutta"},{"full_name":"Benková, Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","last_name":"Benková","first_name":"Eva"}],"intvolume":"        11","publication_identifier":{"eissn":["2041-1723"]},"year":"2020","status":"public","month":"05","scopus_import":"1","title":"Synergistic on Auxin and Cytokinin 1 positively regulates growth and attenuates soil pathogen resistance","quality_controlled":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"file":[{"file_name":"2020_NatureComm_Hurny.pdf","access_level":"open_access","date_created":"2020-10-06T07:47:53Z","date_updated":"2020-10-06T07:47:53Z","file_id":"8614","creator":"dernst","content_type":"application/pdf","file_size":4743576,"success":1,"checksum":"2cba327c9e9416d75cb96be54b0fb441","relation":"main_file"}],"doi":"10.1038/s41467-020-15895-5","oa_version":"Published Version","file_date_updated":"2020-10-06T07:47:53Z","external_id":{"pmid":["32358503"],"isi":["000531425900012"]},"ddc":["570"],"acknowledgement":"We thank Daria Siekhaus, Jiri Friml and Alexander Johnson for critical reading of the manuscript, Peter Pimpl, Christian Luschnig and Liwen Jiang for sharing published material, Lesia Rodriguez Solovey for technical assistance. This work was supported by the Austrian Science Fund (FWF01_I1774S) to A.H., K.Ö., and E.B., the German Research Foundation (DFG; He3424/6-1 to I.H.), by the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n° [291734] (to N.C.), by the EU in the framework of the Marie-Curie FP7 COFUND People Programme through the award of an AgreenSkills+ fellowship No. 609398 (to J.S.) and by the Scientific Service Units of IST-Austria through resources provided by the Bioimaging Facility, the Life Science Facility. The IJPB benefits from the support of Saclay Plant Sciences-SPS (ANR-17-EUR-0007).","publication":"Nature Communications","pmid":1,"article_processing_charge":"No"},{"publisher":"eLife Sciences Publications","day":"11","_id":"7909","article_type":"original","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Cell migration entails networks and bundles of actin filaments termed lamellipodia and microspikes or filopodia, respectively, as well as focal adhesions, all of which recruit Ena/VASP family members hitherto thought to antagonize efficient cell motility. However, we find these proteins to act as positive regulators of migration in different murine cell lines. CRISPR/Cas9-mediated loss of Ena/VASP proteins reduced lamellipodial actin assembly and perturbed lamellipodial architecture, as evidenced by changed network geometry as well as reduction of filament length and number that was accompanied by abnormal Arp2/3 complex and heterodimeric capping protein accumulation. Loss of Ena/VASP function also abolished the formation of microspikes normally embedded in lamellipodia, but not of filopodia capable of emanating without lamellipodia. Ena/VASP-deficiency also impaired integrin-mediated adhesion accompanied by reduced traction forces exerted through these structures. Our data thus uncover novel Ena/VASP functions of these actin polymerases that are fully consistent with their promotion of cell migration."}],"date_updated":"2026-04-02T14:32:12Z","type":"journal_article","volume":9,"project":[{"name":"Cellular Navigation Along Spatial Gradients","_id":"25FE9508-B435-11E9-9278-68D0E5697425","grant_number":"724373","call_identifier":"H2020"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_number":"e55351","citation":{"mla":"Damiano-Guercio, Julia, et al. “Loss of Ena/VASP Interferes with Lamellipodium Architecture, Motility and Integrin-Dependent Adhesion.” <i>ELife</i>, vol. 9, e55351, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/eLife.55351\">10.7554/eLife.55351</a>.","short":"J. Damiano-Guercio, L. Kurzawa, J. Müller, G.A. Dimchev, M. Schaks, M. Nemethova, T. Pokrant, S. Brühmann, J. Linkner, L. Blanchoin, M.K. Sixt, K. Rottner, J. Faix, ELife 9 (2020).","ama":"Damiano-Guercio J, Kurzawa L, Müller J, et al. Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/eLife.55351\">10.7554/eLife.55351</a>","apa":"Damiano-Guercio, J., Kurzawa, L., Müller, J., Dimchev, G. A., Schaks, M., Nemethova, M., … Faix, J. (2020). Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.55351\">https://doi.org/10.7554/eLife.55351</a>","ieee":"J. Damiano-Guercio <i>et al.</i>, “Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020.","chicago":"Damiano-Guercio, Julia, Laëtitia Kurzawa, Jan Müller, Georgi A Dimchev, Matthias Schaks, Maria Nemethova, Thomas Pokrant, et al. “Loss of Ena/VASP Interferes with Lamellipodium Architecture, Motility and Integrin-Dependent Adhesion.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/eLife.55351\">https://doi.org/10.7554/eLife.55351</a>.","ista":"Damiano-Guercio J, Kurzawa L, Müller J, Dimchev GA, Schaks M, Nemethova M, Pokrant T, Brühmann S, Linkner J, Blanchoin L, Sixt MK, Rottner K, Faix J. 2020. Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion. eLife. 9, e55351."},"intvolume":"         9","publication_identifier":{"eissn":["2050-084X"]},"author":[{"full_name":"Damiano-Guercio, Julia","first_name":"Julia","last_name":"Damiano-Guercio"},{"full_name":"Kurzawa, Laëtitia","first_name":"Laëtitia","last_name":"Kurzawa"},{"last_name":"Müller","first_name":"Jan","id":"AD07FDB4-0F61-11EA-8158-C4CC64CEAA8D","full_name":"Müller, Jan"},{"full_name":"Dimchev, Georgi A","id":"38C393BE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8370-6161","last_name":"Dimchev","first_name":"Georgi A"},{"first_name":"Matthias","last_name":"Schaks","full_name":"Schaks, Matthias"},{"last_name":"Nemethova","first_name":"Maria","full_name":"Nemethova, Maria","id":"34E27F1C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Pokrant, Thomas","last_name":"Pokrant","first_name":"Thomas"},{"full_name":"Brühmann, Stefan","first_name":"Stefan","last_name":"Brühmann"},{"first_name":"Joern","last_name":"Linkner","full_name":"Linkner, Joern"},{"full_name":"Blanchoin, Laurent","last_name":"Blanchoin","first_name":"Laurent"},{"orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","first_name":"Michael K","last_name":"Sixt"},{"last_name":"Rottner","first_name":"Klemens","full_name":"Rottner, Klemens"},{"last_name":"Faix","first_name":"Jan","full_name":"Faix, Jan"}],"isi":1,"date_created":"2020-05-31T22:00:49Z","month":"05","status":"public","year":"2020","date_published":"2020-05-11T00:00:00Z","ec_funded":1,"department":[{"_id":"MiSi"}],"publication_status":"published","publication":"eLife","pmid":1,"article_processing_charge":"No","quality_controlled":"1","title":"Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion","scopus_import":"1","ddc":["570"],"external_id":{"isi":["000537208000001"],"pmid":["32391788"]},"doi":"10.7554/eLife.55351","oa_version":"Published Version","file_date_updated":"2020-07-14T12:48:05Z","file":[{"relation":"main_file","file_name":"2020_eLife_Damiano_Guercio.pdf","access_level":"open_access","date_updated":"2020-07-14T12:48:05Z","date_created":"2020-06-02T10:35:37Z","creator":"dernst","content_type":"application/pdf","file_id":"7914","file_size":10535713,"checksum":"d33bd4441b9a0195718ce1ba5d2c48a6"}]},{"article_type":"original","_id":"8737","day":"30","publisher":"American Association for the Advancement of Science","volume":370,"type":"journal_article","project":[{"call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Mitochondrial complex I couples NADH:ubiquinone oxidoreduction to proton pumping by an unknown mechanism. Here, we present cryo-electron microscopy structures of ovine complex I in five different conditions, including turnover, at resolutions up to 2.3 to 2.5 angstroms. Resolved water molecules allowed us to experimentally define the proton translocation pathways. Quinone binds at three positions along the quinone cavity, as does the inhibitor rotenone that also binds within subunit ND4. Dramatic conformational changes around the quinone cavity couple the redox reaction to proton translocation during open-to-closed state transitions of the enzyme. In the induced deactive state, the open conformation is arrested by the ND6 subunit. We propose a detailed molecular coupling mechanism of complex I, which is an unexpected combination of conformational changes and electrostatic interactions."}],"date_updated":"2026-04-02T14:32:34Z","citation":{"apa":"Kampjut, D., &#38; Sazanov, L. A. (2020). The coupling mechanism of mammalian respiratory complex I. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abc4209\">https://doi.org/10.1126/science.abc4209</a>","chicago":"Kampjut, Domen, and Leonid A Sazanov. “The Coupling Mechanism of Mammalian Respiratory Complex I.” <i>Science</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/science.abc4209\">https://doi.org/10.1126/science.abc4209</a>.","ieee":"D. Kampjut and L. A. Sazanov, “The coupling mechanism of mammalian respiratory complex I,” <i>Science</i>, vol. 370, no. 6516. American Association for the Advancement of Science, 2020.","ista":"Kampjut D, Sazanov LA. 2020. The coupling mechanism of mammalian respiratory complex I. Science. 370(6516), eabc4209.","mla":"Kampjut, Domen, and Leonid A. Sazanov. “The Coupling Mechanism of Mammalian Respiratory Complex I.” <i>Science</i>, vol. 370, no. 6516, eabc4209, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/science.abc4209\">10.1126/science.abc4209</a>.","short":"D. Kampjut, L.A. Sazanov, Science 370 (2020).","ama":"Kampjut D, Sazanov LA. The coupling mechanism of mammalian respiratory complex I. <i>Science</i>. 2020;370(6516). doi:<a href=\"https://doi.org/10.1126/science.abc4209\">10.1126/science.abc4209</a>"},"has_accepted_license":"1","article_number":"eabc4209","issue":"6516","month":"10","status":"public","year":"2020","intvolume":"       370","publication_identifier":{"eissn":["1095-9203"]},"author":[{"last_name":"Kampjut","first_name":"Domen","id":"37233050-F248-11E8-B48F-1D18A9856A87","full_name":"Kampjut, Domen","orcid":"0000-0002-6018-3422"},{"first_name":"Leonid A","last_name":"Sazanov","orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"}],"date_created":"2020-11-08T23:01:23Z","isi":1,"department":[{"_id":"LeSa"}],"publication_status":"published","date_published":"2020-10-30T00:00:00Z","ec_funded":1,"article_processing_charge":"No","pmid":1,"publication":"Science","acknowledgement":"We thank J. Novacek (CEITEC Brno) and V.-V. Hodirnau (IST Austria) for their help with collecting cryo-EM datasets. We thank the IST Life Science and Electron Microscopy Facilities for providing equipment. This work has been supported by iNEXT,project number 653706, funded by the Horizon 2020 program of the European Union. This article reflects only the authors’view,and the European Commission is not responsible for any use that may be made of the information it contains. CIISB research infrastructure project LM2015043 funded by MEYS CR is gratefully acknowledged for the financial support of the measurements at the CF Cryo-electron Microscopy and Tomography CEITEC MU.This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement no. 665385","ddc":["572"],"file_date_updated":"2020-11-26T18:47:58Z","external_id":{"pmid":["32972993"],"isi":["000583031800004"]},"oa_version":"Submitted Version","doi":"10.1126/science.abc4209","file":[{"relation":"main_file","content_type":"application/pdf","creator":"lsazanov","file_id":"8820","success":1,"checksum":"658ba90979ca9528a2efdfac8547047a","file_size":7618987,"access_level":"open_access","file_name":"Full_manuscript_with_SI_opt_red.pdf","date_created":"2020-11-26T18:47:58Z","date_updated":"2020-11-26T18:47:58Z"}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"EM-Fac"}],"quality_controlled":"1","title":"The coupling mechanism of mammalian respiratory complex I","scopus_import":"1"},{"volume":2020,"type":"journal_article","oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","project":[{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"},{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"abstract":[{"text":"Following on from our recent work, we investigate a stochastic approach to non-equilibrium quantum spin systems. We show how the method can be applied to a variety of physical observables and for different initial conditions. We provide exact formulae of broad applicability for the time-dependence of expectation values and correlation functions following a quantum quench in terms of averages over classical stochastic processes. We further explore the behavior of the classical stochastic variables in the presence of dynamical quantum phase transitions, including results for their distributions and correlation functions. We provide details on the numerical solution of the associated stochastic differential equations, and examine the growth of fluctuations in the classical description. We discuss the strengths and limitations of the current implementation of the stochastic approach and the potential for further development.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2026-04-02T14:33:33Z","citation":{"apa":"De Nicola, S., Doyon, B., &#38; Bhaseen, M. J. (2020). Non-equilibrium quantum spin dynamics from classical stochastic processes. <i>Journal of Statistical Mechanics: Theory and Experiment</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1742-5468/ab6093\">https://doi.org/10.1088/1742-5468/ab6093</a>","chicago":"De Nicola, Stefano, B. Doyon, and M. J. Bhaseen. “Non-Equilibrium Quantum Spin Dynamics from Classical Stochastic Processes.” <i>Journal of Statistical Mechanics: Theory and Experiment</i>. IOP Publishing, 2020. <a href=\"https://doi.org/10.1088/1742-5468/ab6093\">https://doi.org/10.1088/1742-5468/ab6093</a>.","ieee":"S. De Nicola, B. Doyon, and M. J. Bhaseen, “Non-equilibrium quantum spin dynamics from classical stochastic processes,” <i>Journal of Statistical Mechanics: Theory and Experiment</i>, vol. 2020, no. 1. IOP Publishing, 2020.","ista":"De Nicola S, Doyon B, Bhaseen MJ. 2020. Non-equilibrium quantum spin dynamics from classical stochastic processes. Journal of Statistical Mechanics: Theory and Experiment. 2020(1), 013106.","mla":"De Nicola, Stefano, et al. “Non-Equilibrium Quantum Spin Dynamics from Classical Stochastic Processes.” <i>Journal of Statistical Mechanics: Theory and Experiment</i>, vol. 2020, no. 1, 013106, IOP Publishing, 2020, doi:<a href=\"https://doi.org/10.1088/1742-5468/ab6093\">10.1088/1742-5468/ab6093</a>.","short":"S. De Nicola, B. Doyon, M.J. Bhaseen, Journal of Statistical Mechanics: Theory and Experiment 2020 (2020).","ama":"De Nicola S, Doyon B, Bhaseen MJ. Non-equilibrium quantum spin dynamics from classical stochastic processes. <i>Journal of Statistical Mechanics: Theory and Experiment</i>. 2020;2020(1). doi:<a href=\"https://doi.org/10.1088/1742-5468/ab6093\">10.1088/1742-5468/ab6093</a>"},"has_accepted_license":"1","issue":"1","article_number":"013106","_id":"7638","article_type":"original","publisher":"IOP Publishing","day":"22","article_processing_charge":"No","publication":"Journal of Statistical Mechanics: Theory and Experiment","file_date_updated":"2020-07-14T12:48:01Z","doi":"10.1088/1742-5468/ab6093","external_id":{"arxiv":["1909.13142"],"isi":["000520187500001"]},"oa_version":"Published Version","ddc":["530"],"file":[{"relation":"main_file","date_updated":"2020-07-14T12:48:01Z","date_created":"2020-04-06T13:15:49Z","file_name":"2020_JournStatisticalMech_DeNicola.pdf","access_level":"open_access","file_size":3159026,"checksum":"4030e683c15d30b7b4794ec7dc1b6537","creator":"dernst","content_type":"application/pdf","file_id":"7648"}],"title":"Non-equilibrium quantum spin dynamics from classical stochastic processes","quality_controlled":"1","scopus_import":"1","status":"public","month":"01","year":"2020","author":[{"last_name":"De Nicola","first_name":"Stefano","full_name":"De Nicola, Stefano","id":"42832B76-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4842-6671"},{"last_name":"Doyon","first_name":"B.","full_name":"Doyon, B."},{"first_name":"M. J.","last_name":"Bhaseen","full_name":"Bhaseen, M. J."}],"intvolume":"      2020","publication_identifier":{"eissn":["1742-5468"]},"date_created":"2020-04-05T22:00:50Z","isi":1,"arxiv":1,"department":[{"_id":"MaSe"}],"publication_status":"published","ec_funded":1,"date_published":"2020-01-22T00:00:00Z","corr_author":"1"},{"quality_controlled":"1","title":"Tracing the cellular basis of islet specification in mouse pancreas","scopus_import":"1","ddc":["570"],"oa_version":"Published Version","file_date_updated":"2020-10-19T11:27:46Z","doi":"10.1038/s41467-020-18837-3","external_id":{"pmid":["33028844"],"isi":["000577244600003"]},"file":[{"checksum":"0ecc0eab72d2d50694852579611a6624","success":1,"file_size":5540540,"content_type":"application/pdf","creator":"dernst","file_id":"8677","date_created":"2020-10-19T11:27:46Z","date_updated":"2020-10-19T11:27:46Z","access_level":"open_access","file_name":"2020_NatureComm_Sznurkowska.pdf","relation":"main_file"}],"pmid":1,"publication":"Nature Communications","article_processing_charge":"No","date_published":"2020-10-07T00:00:00Z","department":[{"_id":"EdHa"}],"publication_status":"published","publication_identifier":{"eissn":["2041-1723"]},"intvolume":"        11","author":[{"last_name":"Sznurkowska","first_name":"Magdalena K.","full_name":"Sznurkowska, Magdalena K."},{"orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","first_name":"Edouard B","last_name":"Hannezo"},{"full_name":"Azzarelli, Roberta","first_name":"Roberta","last_name":"Azzarelli"},{"last_name":"Chatzeli","first_name":"Lemonia","full_name":"Chatzeli, Lemonia"},{"full_name":"Ikeda, Tatsuro","last_name":"Ikeda","first_name":"Tatsuro"},{"first_name":"Shosei","last_name":"Yoshida","full_name":"Yoshida, Shosei"},{"full_name":"Philpott, Anna","last_name":"Philpott","first_name":"Anna"},{"full_name":"Simons, Benjamin D","first_name":"Benjamin D","last_name":"Simons"}],"isi":1,"date_created":"2020-10-18T22:01:35Z","month":"10","status":"public","year":"2020","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_number":"5037","citation":{"ista":"Sznurkowska MK, Hannezo EB, Azzarelli R, Chatzeli L, Ikeda T, Yoshida S, Philpott A, Simons BD. 2020. Tracing the cellular basis of islet specification in mouse pancreas. Nature Communications. 11, 5037.","apa":"Sznurkowska, M. K., Hannezo, E. B., Azzarelli, R., Chatzeli, L., Ikeda, T., Yoshida, S., … Simons, B. D. (2020). Tracing the cellular basis of islet specification in mouse pancreas. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-18837-3\">https://doi.org/10.1038/s41467-020-18837-3</a>","chicago":"Sznurkowska, Magdalena K., Edouard B Hannezo, Roberta Azzarelli, Lemonia Chatzeli, Tatsuro Ikeda, Shosei Yoshida, Anna Philpott, and Benjamin D Simons. “Tracing the Cellular Basis of Islet Specification in Mouse Pancreas.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-18837-3\">https://doi.org/10.1038/s41467-020-18837-3</a>.","ieee":"M. K. Sznurkowska <i>et al.</i>, “Tracing the cellular basis of islet specification in mouse pancreas,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","short":"M.K. Sznurkowska, E.B. Hannezo, R. Azzarelli, L. Chatzeli, T. Ikeda, S. Yoshida, A. Philpott, B.D. Simons, Nature Communications 11 (2020).","ama":"Sznurkowska MK, Hannezo EB, Azzarelli R, et al. Tracing the cellular basis of islet specification in mouse pancreas. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-18837-3\">10.1038/s41467-020-18837-3</a>","mla":"Sznurkowska, Magdalena K., et al. “Tracing the Cellular Basis of Islet Specification in Mouse Pancreas.” <i>Nature Communications</i>, vol. 11, 5037, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-18837-3\">10.1038/s41467-020-18837-3</a>."},"language":[{"iso":"eng"}],"abstract":[{"text":"Pancreatic islets play an essential role in regulating blood glucose level. Although the molecular pathways underlying islet cell differentiation are beginning to be resolved, the cellular basis of islet morphogenesis and fate allocation remain unclear. By combining unbiased and targeted lineage tracing, we address the events leading to islet formation in the mouse. From the statistical analysis of clones induced at multiple embryonic timepoints, here we show that, during the secondary transition, islet formation involves the aggregation of multiple equipotent endocrine progenitors that transition from a phase of stochastic amplification by cell division into a phase of sublineage restriction and limited islet fission. Together, these results explain quantitatively the heterogeneous size distribution and degree of polyclonality of maturing islets, as well as dispersion of progenitors within and between islets. Further, our results show that, during the secondary transition, α- and β-cells are generated in a contemporary manner. Together, these findings provide insight into the cellular basis of islet development.","lang":"eng"}],"date_updated":"2026-04-02T14:29:58Z","type":"journal_article","volume":11,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"publisher":"Springer Nature","day":"07","_id":"8669","article_type":"original"},{"citation":{"apa":"Fischer, J. L., &#38; Kniely, M. (2020). Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model. <i>Nonlinearity</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1361-6544/ab9728\">https://doi.org/10.1088/1361-6544/ab9728</a>","chicago":"Fischer, Julian L, and Michael Kniely. “Variance Reduction for Effective Energies of Random Lattices in the Thomas-Fermi-von Weizsäcker Model.” <i>Nonlinearity</i>. IOP Publishing, 2020. <a href=\"https://doi.org/10.1088/1361-6544/ab9728\">https://doi.org/10.1088/1361-6544/ab9728</a>.","ieee":"J. L. Fischer and M. Kniely, “Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model,” <i>Nonlinearity</i>, vol. 33, no. 11. IOP Publishing, pp. 5733–5772, 2020.","ista":"Fischer JL, Kniely M. 2020. Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model. Nonlinearity. 33(11), 5733–5772.","mla":"Fischer, Julian L., and Michael Kniely. “Variance Reduction for Effective Energies of Random Lattices in the Thomas-Fermi-von Weizsäcker Model.” <i>Nonlinearity</i>, vol. 33, no. 11, IOP Publishing, 2020, pp. 5733–72, doi:<a href=\"https://doi.org/10.1088/1361-6544/ab9728\">10.1088/1361-6544/ab9728</a>.","short":"J.L. Fischer, M. Kniely, Nonlinearity 33 (2020) 5733–5772.","ama":"Fischer JL, Kniely M. Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model. <i>Nonlinearity</i>. 2020;33(11):5733-5772. doi:<a href=\"https://doi.org/10.1088/1361-6544/ab9728\">10.1088/1361-6544/ab9728</a>"},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/3.0/legalcode","short":"CC BY (3.0)","name":"Creative Commons Attribution 3.0 Unported (CC BY 3.0)"},"has_accepted_license":"1","issue":"11","type":"journal_article","volume":33,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"In the computation of the material properties of random alloys, the method of 'special quasirandom structures' attempts to approximate the properties of the alloy on a finite volume with higher accuracy by replicating certain statistics of the random atomic lattice in the finite volume as accurately as possible. In the present work, we provide a rigorous justification for a variant of this method in the framework of the Thomas–Fermi–von Weizsäcker (TFW) model. Our approach is based on a recent analysis of a related variance reduction method in stochastic homogenization of linear elliptic PDEs and the locality properties of the TFW model. Concerning the latter, we extend an exponential locality result by Nazar and Ortner to include point charges, a result that may be of independent interest."}],"date_updated":"2026-04-02T14:31:34Z","page":"5733-5772","article_type":"original","_id":"8697","day":"01","publisher":"IOP Publishing","ddc":["510"],"file_date_updated":"2020-10-27T12:09:57Z","doi":"10.1088/1361-6544/ab9728","oa_version":"Published Version","external_id":{"arxiv":["1906.12245"],"isi":["000576492700001"]},"file":[{"date_updated":"2020-10-27T12:09:57Z","date_created":"2020-10-27T12:09:57Z","file_name":"2020_Nonlinearity_Fischer.pdf","access_level":"open_access","file_size":1223899,"success":1,"checksum":"ed90bc6eb5f32ee6157fef7f3aabc057","content_type":"application/pdf","creator":"cziletti","file_id":"8710","relation":"main_file"}],"quality_controlled":"1","title":"Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model","scopus_import":"1","article_processing_charge":"Yes (via OA deal)","publication":"Nonlinearity","department":[{"_id":"JuFi"}],"publication_status":"published","date_published":"2020-11-01T00:00:00Z","corr_author":"1","month":"11","status":"public","year":"2020","intvolume":"        33","publication_identifier":{"eissn":["1361-6544"],"issn":["0951-7715"]},"author":[{"full_name":"Fischer, Julian L","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0479-558X","last_name":"Fischer","first_name":"Julian L"},{"first_name":"Michael","last_name":"Kniely","orcid":"0000-0001-5645-4333","full_name":"Kniely, Michael","id":"2CA2C08C-F248-11E8-B48F-1D18A9856A87"}],"arxiv":1,"date_created":"2020-10-25T23:01:16Z","isi":1},{"_id":"9208","article_type":"original","publisher":"Springer Nature","day":"01","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","volume":2,"type":"journal_article","date_updated":"2026-04-02T14:31:49Z","language":[{"iso":"eng"}],"abstract":[{"text":"Bending-active structures are able to efficiently produce complex curved shapes from flat panels. The desired deformation of the panels derives from the proper selection of their elastic properties. Optimized panels, called FlexMaps, are designed such that, once they are bent and assembled, the resulting static equilibrium configuration matches a desired input 3D shape. The FlexMaps elastic properties are controlled by locally varying spiraling geometric mesostructures, which are optimized in size and shape to match specific bending requests, namely the global curvature of the target shape. The design pipeline starts from a quad mesh representing the input 3D shape, which defines the edge size and the total amount of spirals: every quad will embed one spiral. Then, an optimization algorithm tunes the geometry of the spirals by using a simplified pre-computed rod model. This rod model is derived from a non-linear regression algorithm which approximates the non-linear behavior of solid FEM spiral models subject to hundreds of load combinations. This innovative pipeline has been applied to the project of a lightweight plywood pavilion named FlexMaps Pavilion, which is a single-layer piecewise twisted arch that fits a bounding box of 3.90x3.96x3.25 meters. This case study serves to test the applicability of this methodology at the architectural scale. The structure is validated via FE analyses and the fabrication of the full scale prototype.","lang":"eng"}],"citation":{"ama":"Laccone F, Malomo L, Perez Rodriguez J, et al. A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion. <i>SN Applied Sciences</i>. 2020;2(9). doi:<a href=\"https://doi.org/10.1007/s42452-020-03305-w\">10.1007/s42452-020-03305-w</a>","short":"F. Laccone, L. Malomo, J. Perez Rodriguez, N. Pietroni, F. Ponchio, B. Bickel, P. Cignoni, SN Applied Sciences 2 (2020).","mla":"Laccone, Francesco, et al. “A Bending-Active Twisted-Arch Plywood Structure: Computational Design and Fabrication of the FlexMaps Pavilion.” <i>SN Applied Sciences</i>, vol. 2, no. 9, 1505, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1007/s42452-020-03305-w\">10.1007/s42452-020-03305-w</a>.","ista":"Laccone F, Malomo L, Perez Rodriguez J, Pietroni N, Ponchio F, Bickel B, Cignoni P. 2020. A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion. SN Applied Sciences. 2(9), 1505.","ieee":"F. Laccone <i>et al.</i>, “A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion,” <i>SN Applied Sciences</i>, vol. 2, no. 9. Springer Nature, 2020.","chicago":"Laccone, Francesco, Luigi Malomo, Jesus Perez Rodriguez, Nico Pietroni, Federico Ponchio, Bernd Bickel, and Paolo Cignoni. “A Bending-Active Twisted-Arch Plywood Structure: Computational Design and Fabrication of the FlexMaps Pavilion.” <i>SN Applied Sciences</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s42452-020-03305-w\">https://doi.org/10.1007/s42452-020-03305-w</a>.","apa":"Laccone, F., Malomo, L., Perez Rodriguez, J., Pietroni, N., Ponchio, F., Bickel, B., &#38; Cignoni, P. (2020). A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion. <i>SN Applied Sciences</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s42452-020-03305-w\">https://doi.org/10.1007/s42452-020-03305-w</a>"},"article_number":"1505","issue":"9","year":"2020","month":"09","status":"public","date_created":"2021-02-28T23:01:25Z","publication_identifier":{"eissn":["2523-3971"]},"intvolume":"         2","author":[{"last_name":"Laccone","first_name":"Francesco","full_name":"Laccone, Francesco"},{"first_name":"Luigi","last_name":"Malomo","full_name":"Malomo, Luigi"},{"last_name":"Perez Rodriguez","first_name":"Jesus","id":"2DC83906-F248-11E8-B48F-1D18A9856A87","full_name":"Perez Rodriguez, Jesus"},{"first_name":"Nico","last_name":"Pietroni","full_name":"Pietroni, Nico"},{"full_name":"Ponchio, Federico","last_name":"Ponchio","first_name":"Federico"},{"first_name":"Bernd","last_name":"Bickel","orcid":"0000-0001-6511-9385","id":"49876194-F248-11E8-B48F-1D18A9856A87","full_name":"Bickel, Bernd"},{"full_name":"Cignoni, Paolo","first_name":"Paolo","last_name":"Cignoni"}],"publication_status":"published","department":[{"_id":"BeBi"}],"date_published":"2020-09-01T00:00:00Z","article_processing_charge":"No","acknowledgement":"The FlexMaps Pavilion has been awarded First Prize at the “Competition and Exhibition of innovative lightweight structures” organized by the IASS Working Group 21 within the FORM and FORCE, joint international conference of IASS Symposium 2019 and Structural Membranes 2019 (Barcelona, 7-11 October 2019) with the following motivation: “for its structural innovation of bending-twisting system, connection constructability and exquisite craftmanship”[20]. The authors would like to acknowledge the Visual Computing Lab Staff of ISTI - CNR, in particular Thomas Alderighi, Marco Callieri, Paolo Pingi; Antonio Rizzo of IPCF - CNR; and the Administrative Staff of ISTI - CNR. This research was partially funded by the EU H2020 Programme EVOCATION: Advanced Visual and Geometric Computing for 3D Capture, Display, and Fabrication (grant no. 813170).","publication":"SN Applied Sciences","doi":"10.1007/s42452-020-03305-w","oa_version":"None","scopus_import":"1","quality_controlled":"1","title":"A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion"},{"acknowledgement":"This paper is dedicated to deceased P. Galuszka for his support and contribution to the project. This research was supported by the Scientific Service Units (SSU) of IST-Austria through resources provided by the Bioimaging Facility (BIF), the Life Science Facility (LSF) and by Centre of the Region Haná (CRH), Palacký University. We thank Lucia Hlusková, Zuzana Pěkná and Martin Hönig for technical assistance, and Fernando Aniento, Rashed Abualia and Andrej Hurný for sharing material. The work was supported from ERDF project “Plants as a tool for sustainable global development” (No. CZ.02.1.01/0.0/0.0/16_019/0000827), from Czech Science Foundation via projects 16-04184S (O.P., K.K. and K.D.), 18-23972Y (D.Z., K.K.), 17-21122S (K.B.), Erasmus+ (K.K.), Endowment Fund of Palacký University (K.K.) and EMBO Long-Term Fellowship, ALTF number 710-2016 (J.C.M.); People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no. [291734] (N.C.); DOC Fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology, Austria (H.S.).","publication":"Nature Communications","pmid":1,"article_processing_charge":"No","scopus_import":"1","quality_controlled":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"title":"Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum","file":[{"relation":"main_file","date_created":"2020-09-10T08:05:19Z","date_updated":"2020-09-10T08:05:19Z","access_level":"open_access","file_name":"2020_NatureComm_Kubiasova.pdf","checksum":"7494b7665b3d2bf2d8edb13e4f12b92d","success":1,"file_size":3455704,"file_id":"8357","creator":"dernst","content_type":"application/pdf"}],"ddc":["580"],"file_date_updated":"2020-09-10T08:05:19Z","doi":"10.1038/s41467-020-17949-0","external_id":{"isi":["000567931000002"],"pmid":["32855390"]},"oa_version":"Published Version","isi":1,"date_created":"2020-09-06T22:01:12Z","publication_identifier":{"eissn":["2041-1723"]},"intvolume":"        11","author":[{"full_name":"Kubiasova, Karolina","id":"946011F4-3E71-11EA-860B-C7A73DDC885E","orcid":"0000-0001-5630-9419","last_name":"Kubiasova","first_name":"Karolina"},{"first_name":"Juan C","last_name":"Montesinos López","orcid":"0000-0001-9179-6099","id":"310A8E3E-F248-11E8-B48F-1D18A9856A87","full_name":"Montesinos López, Juan C"},{"first_name":"Olga","last_name":"Šamajová","full_name":"Šamajová, Olga"},{"last_name":"Nisler","first_name":"Jaroslav","full_name":"Nisler, Jaroslav"},{"last_name":"Mik","first_name":"Václav","full_name":"Mik, Václav"},{"last_name":"Semeradova","first_name":"Hana","full_name":"Semeradova, Hana","id":"42FE702E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Plíhalová, Lucie","last_name":"Plíhalová","first_name":"Lucie"},{"last_name":"Novák","first_name":"Ondřej","full_name":"Novák, Ondřej"},{"first_name":"Peter","last_name":"Marhavý","orcid":"0000-0001-5227-5741","id":"3F45B078-F248-11E8-B48F-1D18A9856A87","full_name":"Marhavý, Peter"},{"id":"457160E6-F248-11E8-B48F-1D18A9856A87","full_name":"Cavallari, Nicola","first_name":"Nicola","last_name":"Cavallari"},{"first_name":"David","last_name":"Zalabák","full_name":"Zalabák, David"},{"full_name":"Berka, Karel","last_name":"Berka","first_name":"Karel"},{"first_name":"Karel","last_name":"Doležal","full_name":"Doležal, Karel"},{"last_name":"Galuszka","first_name":"Petr","full_name":"Galuszka, Petr"},{"first_name":"Jozef","last_name":"Šamaj","full_name":"Šamaj, Jozef"},{"first_name":"Miroslav","last_name":"Strnad","full_name":"Strnad, Miroslav"},{"orcid":"0000-0002-8510-9739","full_name":"Benková, Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","last_name":"Benková"},{"last_name":"Plíhal","first_name":"Ondřej","full_name":"Plíhal, Ondřej"},{"full_name":"Spíchal, Lukáš","last_name":"Spíchal","first_name":"Lukáš"}],"year":"2020","month":"08","status":"public","corr_author":"1","date_published":"2020-08-27T00:00:00Z","ec_funded":1,"publication_status":"published","department":[{"_id":"EvBe"}],"date_updated":"2026-04-02T14:35:13Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Plant hormone cytokinins are perceived by a subfamily of sensor histidine kinases (HKs), which via a two-component phosphorelay cascade activate transcriptional responses in the nucleus. Subcellular localization of the receptors proposed the endoplasmic reticulum (ER) membrane as a principal cytokinin perception site, while study of cytokinin transport pointed to the plasma membrane (PM)-mediated cytokinin signalling. Here, by detailed monitoring of subcellular localizations of the fluorescently labelled natural cytokinin probe and the receptor ARABIDOPSIS HISTIDINE KINASE 4 (CRE1/AHK4) fused to GFP reporter, we show that pools of the ER-located cytokinin receptors can enter the secretory pathway and reach the PM in cells of the root apical meristem, and the cell plate of dividing meristematic cells. Brefeldin A (BFA) experiments revealed vesicular recycling of the receptor and its accumulation in BFA compartments. We provide a revised view on cytokinin signalling and the possibility of multiple sites of perception at PM and ER."}],"project":[{"name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","call_identifier":"FP7"},{"_id":"261821BC-B435-11E9-9278-68D0E5697425","grant_number":"24746","name":"Molecular mechanisms of the cytokinin regulated endomembrane trafficking to coordinate plant organogenesis"},{"name":"Molecular mechanism of auxindriven formative divisions delineating lateral root organogenesis in plants","_id":"253E54C8-B435-11E9-9278-68D0E5697425","grant_number":"ALTF710-2016"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"type":"journal_article","volume":11,"article_number":"4285","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"short":"K. Kubiasova, J.C. Montesinos López, O. Šamajová, J. Nisler, V. Mik, H. Semerádová, L. Plíhalová, O. Novák, P. Marhavý, N. Cavallari, D. Zalabák, K. Berka, K. Doležal, P. Galuszka, J. Šamaj, M. Strnad, E. Benková, O. Plíhal, L. Spíchal, Nature Communications 11 (2020).","ama":"Kubiasova K, Montesinos López JC, Šamajová O, et al. Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-17949-0\">10.1038/s41467-020-17949-0</a>","mla":"Kubiasova, Karolina, et al. “Cytokinin Fluoroprobe Reveals Multiple Sites of Cytokinin Perception at Plasma Membrane and Endoplasmic Reticulum.” <i>Nature Communications</i>, vol. 11, 4285, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-17949-0\">10.1038/s41467-020-17949-0</a>.","ista":"Kubiasova K, Montesinos López JC, Šamajová O, Nisler J, Mik V, Semerádová H, Plíhalová L, Novák O, Marhavý P, Cavallari N, Zalabák D, Berka K, Doležal K, Galuszka P, Šamaj J, Strnad M, Benková E, Plíhal O, Spíchal L. 2020. Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum. Nature Communications. 11, 4285.","apa":"Kubiasova, K., Montesinos López, J. C., Šamajová, O., Nisler, J., Mik, V., Semerádová, H., … Spíchal, L. (2020). Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-17949-0\">https://doi.org/10.1038/s41467-020-17949-0</a>","ieee":"K. Kubiasova <i>et al.</i>, “Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","chicago":"Kubiasova, Karolina, Juan C Montesinos López, Olga Šamajová, Jaroslav Nisler, Václav Mik, Hana Semerádová, Lucie Plíhalová, et al. “Cytokinin Fluoroprobe Reveals Multiple Sites of Cytokinin Perception at Plasma Membrane and Endoplasmic Reticulum.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-17949-0\">https://doi.org/10.1038/s41467-020-17949-0</a>."},"publisher":"Springer Nature","day":"27","_id":"8336","article_type":"original"},{"pmid":1,"publication":"Plants","article_processing_charge":"No","scopus_import":"1","quality_controlled":"1","title":"Molecular evolution and diversification of proteins involved in miRNA maturation pathway","file":[{"relation":"main_file","content_type":"application/pdf","file_id":"7614","creator":"dernst","file_size":2373484,"checksum":"6d5af3e17266a48996b4af4e67e88a85","file_name":"2020_Plants_Moturu.pdf","access_level":"open_access","date_created":"2020-03-23T13:37:00Z","date_updated":"2020-07-14T12:48:00Z"}],"ddc":["580"],"external_id":{"pmid":["32121542"],"isi":["000525315000035"]},"file_date_updated":"2020-07-14T12:48:00Z","doi":"10.3390/plants9030299","oa_version":"Published Version","isi":1,"date_created":"2020-03-15T23:00:52Z","publication_identifier":{"eissn":["2223-7747"]},"intvolume":"         9","author":[{"full_name":"Moturu, Taraka Ramji","first_name":"Taraka Ramji","last_name":"Moturu"},{"full_name":"Sinha, Sansrity","first_name":"Sansrity","last_name":"Sinha"},{"first_name":"Hymavathi","last_name":"Salava","full_name":"Salava, Hymavathi"},{"first_name":"Sravankumar","last_name":"Thula","full_name":"Thula, Sravankumar"},{"full_name":"Nodzyński, Tomasz","last_name":"Nodzyński","first_name":"Tomasz"},{"full_name":"Vařeková, Radka Svobodová","last_name":"Vařeková","first_name":"Radka Svobodová"},{"orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří","last_name":"Friml"},{"orcid":"0000-0002-1998-6741","full_name":"Simon, Sibu","id":"4542EF9A-F248-11E8-B48F-1D18A9856A87","first_name":"Sibu","last_name":"Simon"}],"year":"2020","month":"03","status":"public","corr_author":"1","date_published":"2020-03-01T00:00:00Z","ec_funded":1,"publication_status":"published","department":[{"_id":"JiFr"}],"date_updated":"2026-04-02T14:35:47Z","language":[{"iso":"eng"}],"abstract":[{"text":"Small RNAs (smRNA, 19–25 nucleotides long), which are transcribed by RNA polymerase II, regulate the expression of genes involved in a multitude of processes in eukaryotes. miRNA biogenesis and the proteins involved in the biogenesis pathway differ across plant and animal lineages. The major proteins constituting the biogenesis pathway, namely, the Dicers (DCL/DCR) and Argonautes (AGOs), have been extensively studied. However, the accessory proteins (DAWDLE (DDL), SERRATE (SE), and TOUGH (TGH)) of the pathway that differs across the two lineages remain largely uncharacterized. We present the first detailed report on the molecular evolution and divergence of these proteins across eukaryotes. Although DDL is present in eukaryotes and prokaryotes, SE and TGH appear to be specific to eukaryotes. The addition/deletion of specific domains and/or domain-specific sequence divergence in the three proteins points to the observed functional divergence of these proteins across the two lineages, which correlates with the differences in miRNA length across the two lineages. Our data enhance the current understanding of the structure–function relationship of these proteins and reveals previous unexplored crucial residues in the three proteins that can be used as a basis for further functional characterization. The data presented here on the number of miRNAs in crown eukaryotic lineages are consistent with the notion of the expansion of the number of miRNA-coding genes in animal and plant lineages correlating with organismal complexity. Whether this difference in functionally correlates with the diversification (or presence/absence) of the three proteins studied here or the miRNA signaling in the plant and animal lineages is unclear. Based on our results of the three proteins studied here and previously available data concerning the evolution of miRNA genes in the plant and animal lineages, we believe that miRNAs probably evolved once in the ancestor to crown eukaryotes and have diversified independently in the eukaryotes.","lang":"eng"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","project":[{"name":"Polarity and subcellular dynamics in plants","call_identifier":"FP7","_id":"25716A02-B435-11E9-9278-68D0E5697425","grant_number":"282300"}],"oa":1,"volume":9,"type":"journal_article","article_number":"299","issue":"3","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"short":"T.R. Moturu, S. Sinha, H. Salava, S. Thula, T. Nodzyński, R.S. Vařeková, J. Friml, S. Simon, Plants 9 (2020).","ama":"Moturu TR, Sinha S, Salava H, et al. Molecular evolution and diversification of proteins involved in miRNA maturation pathway. <i>Plants</i>. 2020;9(3). doi:<a href=\"https://doi.org/10.3390/plants9030299\">10.3390/plants9030299</a>","mla":"Moturu, Taraka Ramji, et al. “Molecular Evolution and Diversification of Proteins Involved in MiRNA Maturation Pathway.” <i>Plants</i>, vol. 9, no. 3, 299, MDPI, 2020, doi:<a href=\"https://doi.org/10.3390/plants9030299\">10.3390/plants9030299</a>.","ista":"Moturu TR, Sinha S, Salava H, Thula S, Nodzyński T, Vařeková RS, Friml J, Simon S. 2020. Molecular evolution and diversification of proteins involved in miRNA maturation pathway. Plants. 9(3), 299.","apa":"Moturu, T. R., Sinha, S., Salava, H., Thula, S., Nodzyński, T., Vařeková, R. S., … Simon, S. (2020). Molecular evolution and diversification of proteins involved in miRNA maturation pathway. <i>Plants</i>. MDPI. <a href=\"https://doi.org/10.3390/plants9030299\">https://doi.org/10.3390/plants9030299</a>","ieee":"T. R. Moturu <i>et al.</i>, “Molecular evolution and diversification of proteins involved in miRNA maturation pathway,” <i>Plants</i>, vol. 9, no. 3. MDPI, 2020.","chicago":"Moturu, Taraka Ramji, Sansrity Sinha, Hymavathi Salava, Sravankumar Thula, Tomasz Nodzyński, Radka Svobodová Vařeková, Jiří Friml, and Sibu Simon. “Molecular Evolution and Diversification of Proteins Involved in MiRNA Maturation Pathway.” <i>Plants</i>. MDPI, 2020. <a href=\"https://doi.org/10.3390/plants9030299\">https://doi.org/10.3390/plants9030299</a>."},"day":"01","publisher":"MDPI","_id":"7582","article_type":"original"},{"page":"608-621","day":"01","publisher":"Elsevier","_id":"7957","article_type":"original","issue":"8","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","citation":{"mla":"Parenti, Ilaria, et al. “Neurodevelopmental Disorders: From Genetics to Functional Pathways.” <i>Trends in Neurosciences</i>, vol. 43, no. 8, Elsevier, 2020, pp. 608–21, doi:<a href=\"https://doi.org/10.1016/j.tins.2020.05.004\">10.1016/j.tins.2020.05.004</a>.","short":"I. Parenti, L.E. Garcia Rabaneda, H. Schön, G. Novarino, Trends in Neurosciences 43 (2020) 608–621.","ama":"Parenti I, Garcia Rabaneda LE, Schön H, Novarino G. Neurodevelopmental disorders: From genetics to functional pathways. <i>Trends in Neurosciences</i>. 2020;43(8):608-621. doi:<a href=\"https://doi.org/10.1016/j.tins.2020.05.004\">10.1016/j.tins.2020.05.004</a>","apa":"Parenti, I., Garcia Rabaneda, L. E., Schön, H., &#38; Novarino, G. (2020). Neurodevelopmental disorders: From genetics to functional pathways. <i>Trends in Neurosciences</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tins.2020.05.004\">https://doi.org/10.1016/j.tins.2020.05.004</a>","ieee":"I. Parenti, L. E. Garcia Rabaneda, H. Schön, and G. Novarino, “Neurodevelopmental disorders: From genetics to functional pathways,” <i>Trends in Neurosciences</i>, vol. 43, no. 8. Elsevier, pp. 608–621, 2020.","chicago":"Parenti, Ilaria, Luis E Garcia Rabaneda, Hanna Schön, and Gaia Novarino. “Neurodevelopmental Disorders: From Genetics to Functional Pathways.” <i>Trends in Neurosciences</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.tins.2020.05.004\">https://doi.org/10.1016/j.tins.2020.05.004</a>.","ista":"Parenti I, Garcia Rabaneda LE, Schön H, Novarino G. 2020. Neurodevelopmental disorders: From genetics to functional pathways. Trends in Neurosciences. 43(8), 608–621."},"date_updated":"2026-04-02T14:36:06Z","language":[{"iso":"eng"}],"abstract":[{"text":"Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development and function and are characterized by wide genetic and clinical variability. In this review, we discuss the multiple factors that influence the clinical presentation of NDDs, with particular attention to gene vulnerability, mutational load, and the two-hit model. Despite the complex architecture of\r\nmutational events associated with NDDs, the various proteins involved appear to converge on common pathways, such as synaptic plasticity/function, chromatin remodelers and the mammalian target of rapamycin (mTOR) pathway. A thorough understanding of the mechanisms behind these pathways will hopefully lead to the identification of candidates that could be targeted for treatment approaches.","lang":"eng"}],"project":[{"call_identifier":"H2020","_id":"25444568-B435-11E9-9278-68D0E5697425","grant_number":"715508","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"volume":43,"type":"journal_article","corr_author":"1","date_published":"2020-08-01T00:00:00Z","ec_funded":1,"publication_status":"published","department":[{"_id":"GaNo"}],"isi":1,"date_created":"2020-06-14T22:00:49Z","publication_identifier":{"eissn":["1878-108X"],"issn":["0166-2236"]},"intvolume":"        43","author":[{"full_name":"Parenti, Ilaria","id":"D93538B0-5B71-11E9-AC62-02EBE5697425","first_name":"Ilaria","last_name":"Parenti"},{"first_name":"Luis E","last_name":"Garcia Rabaneda","id":"33D1B084-F248-11E8-B48F-1D18A9856A87","full_name":"Garcia Rabaneda, Luis E"},{"id":"C8E17EDC-D7AA-11E9-B7B7-45ECE5697425","full_name":"Schön, Hanna","last_name":"Schön","first_name":"Hanna"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","last_name":"Novarino","first_name":"Gaia"}],"year":"2020","month":"08","status":"public","scopus_import":"1","quality_controlled":"1","title":"Neurodevelopmental disorders: From genetics to functional pathways","file":[{"relation":"main_file","date_updated":"2020-11-25T09:43:40Z","date_created":"2020-11-25T09:43:40Z","file_name":"2020_TrendsNeuroscience_Parenti.pdf","access_level":"open_access","file_size":1439550,"success":1,"checksum":"67db0251b1d415ae59005f876fcf9e34","file_id":"8805","creator":"dernst","content_type":"application/pdf"}],"ddc":["570"],"file_date_updated":"2020-11-25T09:43:40Z","external_id":{"isi":["000553090600008"],"pmid":["32507511"]},"doi":"10.1016/j.tins.2020.05.004","oa_version":"Published Version","acknowledgement":"We wish to thank Jasmin Morandell for generously sharing Figure 2. This work was supported by the European Research Council Starting Grant (grant 715508 ) to G.N.","pmid":1,"publication":"Trends in Neurosciences","article_processing_charge":"No"},{"article_type":"original","_id":"8318","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/mystery-of-giant-proton-pump-solved/","relation":"press_release"}]},"publisher":"Springer Nature","day":"18","citation":{"ama":"Gutierrez-Fernandez J, Kaszuba K, Minhas GS, et al. Key role of quinone in the mechanism of respiratory complex I. <i>Nature Communications</i>. 2020;11(1). doi:<a href=\"https://doi.org/10.1038/s41467-020-17957-0\">10.1038/s41467-020-17957-0</a>","short":"J. Gutierrez-Fernandez, K. Kaszuba, G.S. Minhas, R. Baradaran, M. Tambalo, D.T. Gallagher, L.A. Sazanov, Nature Communications 11 (2020).","mla":"Gutierrez-Fernandez, Javier, et al. “Key Role of Quinone in the Mechanism of Respiratory Complex I.” <i>Nature Communications</i>, vol. 11, no. 1, 4135, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-17957-0\">10.1038/s41467-020-17957-0</a>.","ista":"Gutierrez-Fernandez J, Kaszuba K, Minhas GS, Baradaran R, Tambalo M, Gallagher DT, Sazanov LA. 2020. Key role of quinone in the mechanism of respiratory complex I. Nature Communications. 11(1), 4135.","ieee":"J. Gutierrez-Fernandez <i>et al.</i>, “Key role of quinone in the mechanism of respiratory complex I,” <i>Nature Communications</i>, vol. 11, no. 1. Springer Nature, 2020.","chicago":"Gutierrez-Fernandez, Javier, Karol Kaszuba, Gurdeep S. Minhas, Rozbeh Baradaran, Margherita Tambalo, David T. Gallagher, and Leonid A Sazanov. “Key Role of Quinone in the Mechanism of Respiratory Complex I.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-17957-0\">https://doi.org/10.1038/s41467-020-17957-0</a>.","apa":"Gutierrez-Fernandez, J., Kaszuba, K., Minhas, G. S., Baradaran, R., Tambalo, M., Gallagher, D. T., &#38; Sazanov, L. A. (2020). Key role of quinone in the mechanism of respiratory complex I. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-17957-0\">https://doi.org/10.1038/s41467-020-17957-0</a>"},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","issue":"1","article_number":"4135","type":"journal_article","volume":11,"oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","abstract":[{"text":"Complex I is the first and the largest enzyme of respiratory chains in bacteria and mitochondria. The mechanism which couples spatially separated transfer of electrons to proton translocation in complex I is not known. Here we report five crystal structures of T. thermophilus enzyme in complex with NADH or quinone-like compounds. We also determined cryo-EM structures of major and minor native states of the complex, differing in the position of the peripheral arm. Crystal structures show that binding of quinone-like compounds (but not of NADH) leads to a related global conformational change, accompanied by local re-arrangements propagating from the quinone site to the nearest proton channel. Normal mode and molecular dynamics analyses indicate that these are likely to represent the first steps in the proton translocation mechanism. Our results suggest that quinone binding and chemistry play a key role in the coupling mechanism of complex I.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2026-04-02T14:36:31Z","department":[{"_id":"LeSa"}],"publication_status":"published","date_published":"2020-08-18T00:00:00Z","status":"public","month":"08","year":"2020","author":[{"last_name":"Gutierrez-Fernandez","first_name":"Javier","full_name":"Gutierrez-Fernandez, Javier","id":"3D9511BA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Karol","last_name":"Kaszuba","full_name":"Kaszuba, Karol","id":"3FDF9472-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Minhas","first_name":"Gurdeep S.","full_name":"Minhas, Gurdeep S."},{"full_name":"Baradaran, Rozbeh","first_name":"Rozbeh","last_name":"Baradaran"},{"id":"4187dfe4-ec23-11ea-ae46-f08ab378313a","full_name":"Tambalo, Margherita","last_name":"Tambalo","first_name":"Margherita"},{"last_name":"Gallagher","first_name":"David T.","full_name":"Gallagher, David T."},{"full_name":"Sazanov, Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989","last_name":"Sazanov","first_name":"Leonid A"}],"publication_identifier":{"eissn":["2041-1723"]},"intvolume":"        11","date_created":"2020-08-30T22:01:10Z","isi":1,"doi":"10.1038/s41467-020-17957-0","external_id":{"pmid":["32811817"],"isi":["000607072900001"]},"oa_version":"Published Version","file_date_updated":"2020-08-31T13:40:00Z","ddc":["570"],"file":[{"relation":"main_file","file_size":7527373,"checksum":"52b96f41d7d0db9728064c08da00d030","success":1,"file_id":"8326","content_type":"application/pdf","creator":"cziletti","date_created":"2020-08-31T13:40:00Z","date_updated":"2020-08-31T13:40:00Z","file_name":"2020_NatComm_Gutierrez-Fernandez.pdf","access_level":"open_access"}],"title":"Key role of quinone in the mechanism of respiratory complex I","quality_controlled":"1","scopus_import":"1","article_processing_charge":"No","pmid":1,"publication":"Nature Communications","acknowledgement":"This work was funded by the Medical Research Council, UK and IST Austria. We thank the European Synchrotron Radiation Facility and the Diamond Light Source for provision of synchrotron radiation facilities. We are grateful to the staff of beamlines ID29, ID23-2 (ESRF, Grenoble, France) and I03 (Diamond Light Source, Didcot, UK) for assistance. Data processing was performed at the IST high-performance computing cluster."},{"isi":1,"date_created":"2020-05-24T22:01:00Z","publication_identifier":{"eissn":["2227-7390"]},"intvolume":"         8","author":[{"first_name":"Jeremy R.","last_name":"Armstrong","full_name":"Armstrong, Jeremy R."},{"first_name":"Aksel S.","last_name":"Jensen","full_name":"Jensen, Aksel S."},{"last_name":"Volosniev","first_name":"Artem","full_name":"Volosniev, Artem","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0393-5525"},{"first_name":"Nikolaj T.","last_name":"Zinner","full_name":"Zinner, Nikolaj T."}],"year":"2020","month":"04","status":"public","date_published":"2020-04-01T00:00:00Z","ec_funded":1,"publication_status":"published","department":[{"_id":"MiLe"}],"publication":"Mathematics","article_processing_charge":"No","scopus_import":"1","quality_controlled":"1","title":"Clusters in separated tubes of tilted dipoles","file":[{"relation":"main_file","checksum":"a05a7df724522203d079673a0d4de4bc","file_size":990540,"content_type":"application/pdf","creator":"dernst","file_id":"7887","date_updated":"2020-07-14T12:48:04Z","date_created":"2020-05-25T14:42:22Z","access_level":"open_access","file_name":"2020_Mathematics_Armstrong.pdf"}],"ddc":["510"],"doi":"10.3390/math8040484","external_id":{"isi":["000531824100024"]},"oa_version":"Published Version","file_date_updated":"2020-07-14T12:48:04Z","day":"01","publisher":"MDPI","_id":"7882","article_type":"original","date_updated":"2026-04-02T14:33:47Z","language":[{"iso":"eng"}],"abstract":[{"text":"A few-body cluster is a building block of a many-body system in a gas phase provided the temperature at most is of the order of the binding energy of this cluster. Here we illustrate this statement by considering a system of tubes filled with dipolar distinguishable particles. We calculate the partition function, which determines the probability to find a few-body cluster at a given temperature. The input for our calculations—the energies of few-body clusters—is estimated using the harmonic approximation. We first describe and demonstrate the validity of our numerical procedure. Then we discuss the results featuring melting of the zero-temperature many-body state into a gas of free particles and few-body clusters. For temperature higher than its binding energy threshold, the dimers overwhelmingly dominate the ensemble, where the remaining probability is in free particles. At very high temperatures free (harmonic oscillator trap-bound) particle dominance is eventually reached. This structure evolution appears both for one and two particles in each layer providing crucial information about the behavior of ultracold dipolar gases. The investigation addresses the transition region between few- and many-body physics as a function of temperature using a system of ten dipoles in five tubes.","lang":"eng"}],"project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"type":"journal_article","volume":8,"article_number":"484","issue":"4","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"ama":"Armstrong JR, Jensen AS, Volosniev A, Zinner NT. Clusters in separated tubes of tilted dipoles. <i>Mathematics</i>. 2020;8(4). doi:<a href=\"https://doi.org/10.3390/math8040484\">10.3390/math8040484</a>","short":"J.R. Armstrong, A.S. Jensen, A. Volosniev, N.T. Zinner, Mathematics 8 (2020).","mla":"Armstrong, Jeremy R., et al. “Clusters in Separated Tubes of Tilted Dipoles.” <i>Mathematics</i>, vol. 8, no. 4, 484, MDPI, 2020, doi:<a href=\"https://doi.org/10.3390/math8040484\">10.3390/math8040484</a>.","ista":"Armstrong JR, Jensen AS, Volosniev A, Zinner NT. 2020. Clusters in separated tubes of tilted dipoles. Mathematics. 8(4), 484.","ieee":"J. R. Armstrong, A. S. Jensen, A. Volosniev, and N. T. Zinner, “Clusters in separated tubes of tilted dipoles,” <i>Mathematics</i>, vol. 8, no. 4. MDPI, 2020.","chicago":"Armstrong, Jeremy R., Aksel S. Jensen, Artem Volosniev, and Nikolaj T. Zinner. “Clusters in Separated Tubes of Tilted Dipoles.” <i>Mathematics</i>. MDPI, 2020. <a href=\"https://doi.org/10.3390/math8040484\">https://doi.org/10.3390/math8040484</a>.","apa":"Armstrong, J. R., Jensen, A. S., Volosniev, A., &#38; Zinner, N. T. (2020). Clusters in separated tubes of tilted dipoles. <i>Mathematics</i>. MDPI. <a href=\"https://doi.org/10.3390/math8040484\">https://doi.org/10.3390/math8040484</a>"}},{"publisher":"Springer Nature","day":"19","article_type":"original","_id":"8036","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_number":"112","citation":{"apa":"Collard, Y., Grosjean, G. M., &#38; Vandewalle, N. (2020). Magnetically powered metachronal waves induce locomotion in self-assemblies. <i>Communications Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42005-020-0380-9\">https://doi.org/10.1038/s42005-020-0380-9</a>","chicago":"Collard, Ylona, Galien M Grosjean, and Nicolas Vandewalle. “Magnetically Powered Metachronal Waves Induce Locomotion in Self-Assemblies.” <i>Communications Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s42005-020-0380-9\">https://doi.org/10.1038/s42005-020-0380-9</a>.","ieee":"Y. Collard, G. M. Grosjean, and N. Vandewalle, “Magnetically powered metachronal waves induce locomotion in self-assemblies,” <i>Communications Physics</i>, vol. 3. Springer Nature, 2020.","ista":"Collard Y, Grosjean GM, Vandewalle N. 2020. Magnetically powered metachronal waves induce locomotion in self-assemblies. Communications Physics. 3, 112.","mla":"Collard, Ylona, et al. “Magnetically Powered Metachronal Waves Induce Locomotion in Self-Assemblies.” <i>Communications Physics</i>, vol. 3, 112, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s42005-020-0380-9\">10.1038/s42005-020-0380-9</a>.","short":"Y. Collard, G.M. Grosjean, N. Vandewalle, Communications Physics 3 (2020).","ama":"Collard Y, Grosjean GM, Vandewalle N. Magnetically powered metachronal waves induce locomotion in self-assemblies. <i>Communications Physics</i>. 2020;3. doi:<a href=\"https://doi.org/10.1038/s42005-020-0380-9\">10.1038/s42005-020-0380-9</a>"},"abstract":[{"text":"When tiny soft ferromagnetic particles are placed along a liquid interface and exposed to a vertical magnetic field, the balance between capillary attraction and magnetic repulsion leads to self-organization into well-defined patterns. Here, we demonstrate experimentally that precessing magnetic fields induce metachronal waves on the periphery of these assemblies, similar to the ones observed in ciliates and some arthropods. The outermost layer of particles behaves like an array of cilia or legs whose sequential movement causes a net and controllable locomotion. This bioinspired many-particle swimming strategy is effective even at low Reynolds number, using only spatially uniform fields to generate the waves.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2026-04-02T14:34:21Z","volume":3,"type":"journal_article","oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","project":[{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"ec_funded":1,"date_published":"2020-06-19T00:00:00Z","department":[{"_id":"ScWa"}],"publication_status":"published","author":[{"last_name":"Collard","first_name":"Ylona","full_name":"Collard, Ylona"},{"full_name":"Grosjean, Galien M","id":"0C5FDA4A-9CF6-11E9-8939-FF05E6697425","orcid":"0000-0001-5154-417X","last_name":"Grosjean","first_name":"Galien M"},{"full_name":"Vandewalle, Nicolas","first_name":"Nicolas","last_name":"Vandewalle"}],"intvolume":"         3","publication_identifier":{"eissn":["2399-3650"]},"date_created":"2020-06-29T07:59:35Z","isi":1,"status":"public","month":"06","year":"2020","title":"Magnetically powered metachronal waves induce locomotion in self-assemblies","quality_controlled":"1","scopus_import":"1","oa_version":"Published Version","file_date_updated":"2020-07-14T12:48:08Z","doi":"10.1038/s42005-020-0380-9","external_id":{"isi":["000543328000002"]},"ddc":["530"],"file":[{"relation":"main_file","access_level":"open_access","file_name":"2020_CommunicationsPhysics_Collard.pdf","date_created":"2020-06-29T13:21:24Z","date_updated":"2020-07-14T12:48:08Z","file_id":"8045","content_type":"application/pdf","creator":"cziletti","checksum":"ed984f7a393f19140b5279a54a3336ad","file_size":1907821}],"publication":"Communications Physics","article_processing_charge":"No"}]