[{"intvolume":"        53","type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","date_published":"2020-06-17T00:00:00Z","date_updated":"2023-08-22T07:36:36Z","citation":{"mla":"Vampa, Giulio, et al. “Attosecond Synchronization of Extreme Ultraviolet High Harmonics from Crystals.” <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>, vol. 53, no. 14, 144003, IOP Publishing, 2020, doi:<a href=\"https://doi.org/10.1088/1361-6455/ab8e56\">10.1088/1361-6455/ab8e56</a>.","short":"G. Vampa, J. Lu, Y.S. You, D.R. Baykusheva, M. Wu, H. Liu, K.J. Schafer, M.B. Gaarde, D.A. Reis, S. Ghimire, Journal of Physics B: Atomic, Molecular and Optical Physics 53 (2020).","apa":"Vampa, G., Lu, J., You, Y. S., Baykusheva, D. R., Wu, M., Liu, H., … Ghimire, S. (2020). Attosecond synchronization of extreme ultraviolet high harmonics from crystals. <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1361-6455/ab8e56\">https://doi.org/10.1088/1361-6455/ab8e56</a>","chicago":"Vampa, Giulio, Jian Lu, Yong Sing You, Denitsa Rangelova Baykusheva, Mengxi Wu, Hanzhe Liu, Kenneth J Schafer, Mette B Gaarde, David A Reis, and Shambhu Ghimire. “Attosecond Synchronization of Extreme Ultraviolet High Harmonics from Crystals.” <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>. IOP Publishing, 2020. <a href=\"https://doi.org/10.1088/1361-6455/ab8e56\">https://doi.org/10.1088/1361-6455/ab8e56</a>.","ieee":"G. Vampa <i>et al.</i>, “Attosecond synchronization of extreme ultraviolet high harmonics from crystals,” <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>, vol. 53, no. 14. IOP Publishing, 2020.","ama":"Vampa G, Lu J, You YS, et al. Attosecond synchronization of extreme ultraviolet high harmonics from crystals. <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>. 2020;53(14). doi:<a href=\"https://doi.org/10.1088/1361-6455/ab8e56\">10.1088/1361-6455/ab8e56</a>","ista":"Vampa G, Lu J, You YS, Baykusheva DR, Wu M, Liu H, Schafer KJ, Gaarde MB, Reis DA, Ghimire S. 2020. Attosecond synchronization of extreme ultraviolet high harmonics from crystals. Journal of Physics B: Atomic, Molecular and Optical Physics. 53(14), 144003."},"date_created":"2023-08-09T13:09:51Z","day":"17","article_number":"144003","article_processing_charge":"No","status":"public","publication_identifier":{"eissn":["1361-6455"],"issn":["0953-4075"]},"external_id":{"arxiv":["2001.09951"]},"article_type":"original","publisher":"IOP Publishing","author":[{"full_name":"Vampa, Giulio","first_name":"Giulio","last_name":"Vampa"},{"first_name":"Jian","last_name":"Lu","full_name":"Lu, Jian"},{"full_name":"You, Yong Sing","last_name":"You","first_name":"Yong Sing"},{"full_name":"Baykusheva, Denitsa Rangelova","id":"71b4d059-2a03-11ee-914d-dfa3beed6530","last_name":"Baykusheva","first_name":"Denitsa Rangelova"},{"full_name":"Wu, Mengxi","first_name":"Mengxi","last_name":"Wu"},{"first_name":"Hanzhe","last_name":"Liu","full_name":"Liu, Hanzhe"},{"full_name":"Schafer, Kenneth J","first_name":"Kenneth J","last_name":"Schafer"},{"last_name":"Gaarde","first_name":"Mette B","full_name":"Gaarde, Mette B"},{"first_name":"David A","last_name":"Reis","full_name":"Reis, David A"},{"full_name":"Ghimire, Shambhu","last_name":"Ghimire","first_name":"Shambhu"}],"month":"06","issue":"14","_id":"13998","publication_status":"published","keyword":["Condensed Matter Physics","Atomic and Molecular Physics","and Optics"],"scopus_import":"1","doi":"10.1088/1361-6455/ab8e56","abstract":[{"text":"The interaction of strong near-infrared (NIR) laser pulses with wide-bandgap dielectrics produces high harmonics in the extreme ultraviolet (XUV) wavelength range. These observations have opened up the possibility of attosecond metrology in solids, which would benefit from a precise measurement of the emission times of individual harmonics with respect to the NIR laser field. Here we show that, when high-harmonics are detected from the input surface of a magnesium oxide crystal, a bichromatic probing of the XUV emission shows a clear synchronization largely consistent with a semiclassical model of electron–hole recollisions in bulk solids. On the other hand, the bichromatic spectrogram of harmonics originating from the exit surface of the 200 μm-thick crystal is strongly modified, indicating the influence of laser field distortions during propagation. Our tracking of sub-cycle electron and hole re-collisions at XUV energies is relevant to the development of solid-state sources of attosecond pulses.","lang":"eng"}],"arxiv":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2001.09951"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":53,"title":"Attosecond synchronization of extreme ultraviolet high harmonics from crystals","extern":"1","publication":"Journal of Physics B: Atomic, Molecular and Optical Physics","oa_version":"Preprint","oa":1,"year":"2020"},{"extern":"1","publication":"Nature Physics","title":"Probing molecular environment through photoemission delays","volume":16,"year":"2020","oa_version":"None","month":"07","doi":"10.1038/s41567-020-0887-8","scopus_import":"1","keyword":["General Physics and Astronomy"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Attosecond chronoscopy has revealed small but measurable delays in photoionization, characterized by the ejection of an electron on absorption of a single photon. Ionization-delay measurements in atomic targets provide a wealth of information about the timing of the photoelectric effect, resonances, electron correlations and transport. However, extending this approach to molecules presents challenges, such as identifying the correct ionization channels and the effect of the anisotropic molecular landscape on the measured delays. Here, we measure ionization delays from ethyl iodide around a giant dipole resonance. By using the theoretical value for the iodine atom as a reference, we disentangle the contribution from the functional ethyl group, which is responsible for the characteristic chemical reactivity of a molecule. We find a substantial additional delay caused by the presence of a functional group, which encodes the effect of the molecular potential on the departing electron. Such information is inaccessible to the conventional approach of measuring photoionization cross-sections. The results establish ionization-delay measurements as a valuable tool in investigating the electronic properties of molecules.","lang":"eng"}],"publication_status":"published","page":"778-783","_id":"13999","issue":"7","day":"01","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"article_processing_charge":"No","status":"public","date_created":"2023-08-09T13:10:07Z","article_type":"original","publisher":"Springer Nature","author":[{"full_name":"Biswas, Shubhadeep","last_name":"Biswas","first_name":"Shubhadeep"},{"full_name":"Förg, Benjamin","last_name":"Förg","first_name":"Benjamin"},{"full_name":"Ortmann, Lisa","first_name":"Lisa","last_name":"Ortmann"},{"first_name":"Johannes","last_name":"Schötz","full_name":"Schötz, Johannes"},{"first_name":"Wolfgang","last_name":"Schweinberger","full_name":"Schweinberger, Wolfgang"},{"full_name":"Zimmermann, Tomáš","last_name":"Zimmermann","first_name":"Tomáš"},{"first_name":"Liangwen","last_name":"Pi","full_name":"Pi, Liangwen"},{"id":"71b4d059-2a03-11ee-914d-dfa3beed6530","last_name":"Baykusheva","first_name":"Denitsa Rangelova","full_name":"Baykusheva, Denitsa Rangelova"},{"full_name":"Masood, Hafiz A.","first_name":"Hafiz A.","last_name":"Masood"},{"full_name":"Liontos, Ioannis","last_name":"Liontos","first_name":"Ioannis"},{"full_name":"Kamal, Amgad M.","last_name":"Kamal","first_name":"Amgad M."},{"full_name":"Kling, Nora G.","first_name":"Nora G.","last_name":"Kling"},{"last_name":"Alharbi","first_name":"Abdullah F.","full_name":"Alharbi, Abdullah F."},{"first_name":"Meshaal","last_name":"Alharbi","full_name":"Alharbi, Meshaal"},{"full_name":"Azzeer, Abdallah M.","first_name":"Abdallah M.","last_name":"Azzeer"},{"last_name":"Hartmann","first_name":"Gregor","full_name":"Hartmann, Gregor"},{"last_name":"Wörner","first_name":"Hans J.","full_name":"Wörner, Hans J."},{"full_name":"Landsman, Alexandra S.","first_name":"Alexandra S.","last_name":"Landsman"},{"last_name":"Kling","first_name":"Matthias F.","full_name":"Kling, Matthias F."}],"type":"journal_article","language":[{"iso":"eng"}],"intvolume":"        16","citation":{"ieee":"S. Biswas <i>et al.</i>, “Probing molecular environment through photoemission delays,” <i>Nature Physics</i>, vol. 16, no. 7. Springer Nature, pp. 778–783, 2020.","ista":"Biswas S, Förg B, Ortmann L, Schötz J, Schweinberger W, Zimmermann T, Pi L, Baykusheva DR, Masood HA, Liontos I, Kamal AM, Kling NG, Alharbi AF, Alharbi M, Azzeer AM, Hartmann G, Wörner HJ, Landsman AS, Kling MF. 2020. Probing molecular environment through photoemission delays. Nature Physics. 16(7), 778–783.","ama":"Biswas S, Förg B, Ortmann L, et al. Probing molecular environment through photoemission delays. <i>Nature Physics</i>. 2020;16(7):778-783. doi:<a href=\"https://doi.org/10.1038/s41567-020-0887-8\">10.1038/s41567-020-0887-8</a>","chicago":"Biswas, Shubhadeep, Benjamin Förg, Lisa Ortmann, Johannes Schötz, Wolfgang Schweinberger, Tomáš Zimmermann, Liangwen Pi, et al. “Probing Molecular Environment through Photoemission Delays.” <i>Nature Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41567-020-0887-8\">https://doi.org/10.1038/s41567-020-0887-8</a>.","apa":"Biswas, S., Förg, B., Ortmann, L., Schötz, J., Schweinberger, W., Zimmermann, T., … Kling, M. F. (2020). Probing molecular environment through photoemission delays. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-020-0887-8\">https://doi.org/10.1038/s41567-020-0887-8</a>","mla":"Biswas, Shubhadeep, et al. “Probing Molecular Environment through Photoemission Delays.” <i>Nature Physics</i>, vol. 16, no. 7, Springer Nature, 2020, pp. 778–83, doi:<a href=\"https://doi.org/10.1038/s41567-020-0887-8\">10.1038/s41567-020-0887-8</a>.","short":"S. Biswas, B. Förg, L. Ortmann, J. Schötz, W. Schweinberger, T. Zimmermann, L. Pi, D.R. Baykusheva, H.A. Masood, I. Liontos, A.M. Kamal, N.G. Kling, A.F. Alharbi, M. Alharbi, A.M. Azzeer, G. Hartmann, H.J. Wörner, A.S. Landsman, M.F. Kling, Nature Physics 16 (2020) 778–783."},"date_updated":"2023-08-22T07:38:04Z","quality_controlled":"1","date_published":"2020-07-01T00:00:00Z"},{"language":[{"iso":"eng"}],"type":"book_chapter","month":"09","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"This chapter presents an overview of the state of the art in attosecond time-resolved spectroscopy. The theoretical foundations of strong-field light–matter interaction and attosecond pulse generation are described. The enabling laser technologies are reviewed from chirped-pulse amplification and carrier-envelope-phase stabilization to the generation and characterization of attosecond pulses. The applications of attosecond pulses and pulse trains in electron- or ion-imaging experiments are presented, followed by attosecond electron spectroscopy in larger molecules. After this, high-harmonic spectroscopy and its applications to probing charge migration on attosecond time scales is reviewed. The rapidly evolving field of molecular photoionization delays is discussed. Finally, the applications of attosecond transient absorption to probing molecular dynamics are presented.","lang":"eng"}],"editor":[{"full_name":"Marquardt, Roberto","last_name":"Marquardt","first_name":"Roberto"},{"last_name":"Quack","first_name":"Martin","full_name":"Quack, Martin"}],"doi":"10.1016/b978-0-12-817234-6.00009-x","citation":{"short":"D.R. Baykusheva, H.J. Wörner, in:, R. Marquardt, M. Quack (Eds.), Molecular Spectroscopy and Quantum Dynamics, 1st ed., Elsevier, 2020, pp. 113–161.","mla":"Baykusheva, Denitsa Rangelova, and Hans Jakob Wörner. “Attosecond Molecular Dynamics and Spectroscopy.” <i>Molecular Spectroscopy and Quantum Dynamics</i>, edited by Roberto Marquardt and Martin Quack, 1st ed., Elsevier, 2020, pp. 113–61, doi:<a href=\"https://doi.org/10.1016/b978-0-12-817234-6.00009-x\">10.1016/b978-0-12-817234-6.00009-x</a>.","apa":"Baykusheva, D. R., &#38; Wörner, H. J. (2020). Attosecond Molecular Dynamics and Spectroscopy. In R. Marquardt &#38; M. Quack (Eds.), <i>Molecular Spectroscopy and Quantum Dynamics</i> (1st ed., pp. 113–161). Elsevier. <a href=\"https://doi.org/10.1016/b978-0-12-817234-6.00009-x\">https://doi.org/10.1016/b978-0-12-817234-6.00009-x</a>","chicago":"Baykusheva, Denitsa Rangelova, and Hans Jakob Wörner. “Attosecond Molecular Dynamics and Spectroscopy.” In <i>Molecular Spectroscopy and Quantum Dynamics</i>, edited by Roberto Marquardt and Martin Quack, 1st ed., 113–61. Elsevier, 2020. <a href=\"https://doi.org/10.1016/b978-0-12-817234-6.00009-x\">https://doi.org/10.1016/b978-0-12-817234-6.00009-x</a>.","ista":"Baykusheva DR, Wörner HJ. 2020.Attosecond Molecular Dynamics and Spectroscopy. In: Molecular Spectroscopy and Quantum Dynamics. , 113–161.","ieee":"D. R. Baykusheva and H. J. Wörner, “Attosecond Molecular Dynamics and Spectroscopy,” in <i>Molecular Spectroscopy and Quantum Dynamics</i>, 1st ed., R. Marquardt and M. Quack, Eds. Elsevier, 2020, pp. 113–161.","ama":"Baykusheva DR, Wörner HJ. Attosecond Molecular Dynamics and Spectroscopy. In: Marquardt R, Quack M, eds. <i>Molecular Spectroscopy and Quantum Dynamics</i>. 1st ed. Elsevier; 2020:113-161. doi:<a href=\"https://doi.org/10.1016/b978-0-12-817234-6.00009-x\">10.1016/b978-0-12-817234-6.00009-x</a>"},"scopus_import":"1","date_updated":"2024-10-14T12:26:39Z","date_published":"2020-09-25T00:00:00Z","page":"113-161","publication_status":"published","_id":"14000","quality_controlled":"1","article_processing_charge":"No","publication_identifier":{"eisbn":["0128172355"],"isbn":["9780128172353"]},"publication":"Molecular Spectroscopy and Quantum Dynamics","status":"public","day":"25","extern":"1","title":"Attosecond Molecular Dynamics and Spectroscopy","date_created":"2023-08-09T13:10:23Z","edition":"1","year":"2020","author":[{"full_name":"Baykusheva, Denitsa Rangelova","first_name":"Denitsa Rangelova","last_name":"Baykusheva","id":"71b4d059-2a03-11ee-914d-dfa3beed6530"},{"last_name":"Wörner","first_name":"Hans Jakob","full_name":"Wörner, Hans Jakob"}],"oa_version":"None","publisher":"Elsevier"},{"author":[{"first_name":"Denitsa Rangelova","last_name":"Baykusheva","id":"71b4d059-2a03-11ee-914d-dfa3beed6530","full_name":"Baykusheva, Denitsa Rangelova"},{"full_name":"Wörner, Hans Jakob","last_name":"Wörner","first_name":"Hans Jakob"}],"oa_version":"Preprint","oa":1,"external_id":{"arxiv":["2002.02111"]},"year":"2020","date_created":"2023-08-10T06:47:45Z","title":"Attosecond molecular spectroscopy and dynamics","status":"public","article_processing_charge":"No","extern":"1","day":"01","date_published":"2020-02-01T00:00:00Z","_id":"14028","publication_status":"submitted","page":"2002.02111","arxiv":1,"abstract":[{"text":"The present review addresses the technical advances and the theoretical developments to realize and rationalize attosecond-science experiments that reveal a new dynamical time scale (10−15-10−18 s), with a particular emphasis on molecular systems and the implications of attosecond processes for chemical dynamics. After a brief outline of the theoretical framework for treating non-perturbative phenomena in Section 2, we introduce the physical mechanisms underlying high-harmonic generation and attosecond technology. The relevant technological developments and experimental schemes are covered in Section 3. Throughout the remainder of the chapter, we report on selected applications in molecular attosecond physics, thereby addressing specific phenomena mediated by purely electronic dynamics: charge localization in molecular hydrogen, charge migration in biorelevant molecules, high-harmonic spectroscopy, and delays in molecular photoionization.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2002.02111"}],"date_updated":"2023-08-22T09:17:34Z","citation":{"ama":"Baykusheva DR, Wörner HJ. Attosecond molecular spectroscopy and dynamics. doi:<a href=\"https://doi.org/10.48550/arXiv.2002.02111\">10.48550/arXiv.2002.02111</a>","ista":"Baykusheva DR, Wörner HJ. Attosecond molecular spectroscopy and dynamics. <a href=\"https://doi.org/10.48550/arXiv.2002.02111\">10.48550/arXiv.2002.02111</a>.","ieee":"D. R. Baykusheva and H. J. Wörner, “Attosecond molecular spectroscopy and dynamics.” .","short":"D.R. Baykusheva, H.J. Wörner, (n.d.).","mla":"Baykusheva, Denitsa Rangelova, and Hans Jakob Wörner. <i>Attosecond Molecular Spectroscopy and Dynamics</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2002.02111\">10.48550/arXiv.2002.02111</a>.","apa":"Baykusheva, D. R., &#38; Wörner, H. J. (n.d.). Attosecond molecular spectroscopy and dynamics. <a href=\"https://doi.org/10.48550/arXiv.2002.02111\">https://doi.org/10.48550/arXiv.2002.02111</a>","chicago":"Baykusheva, Denitsa Rangelova, and Hans Jakob Wörner. “Attosecond Molecular Spectroscopy and Dynamics,” n.d. <a href=\"https://doi.org/10.48550/arXiv.2002.02111\">https://doi.org/10.48550/arXiv.2002.02111</a>."},"doi":"10.48550/arXiv.2002.02111","month":"02","language":[{"iso":"eng"}],"type":"preprint"},{"year":"2020","external_id":{"arxiv":["2001.06683"]},"author":[{"full_name":"Gaudi, B. Scott","first_name":"B. Scott","last_name":"Gaudi"},{"full_name":"Seager, Sara","last_name":"Seager","first_name":"Sara"},{"last_name":"Mennesson","first_name":"Bertrand","full_name":"Mennesson, Bertrand"},{"last_name":"Kiessling","first_name":"Alina","full_name":"Kiessling, Alina"},{"first_name":"Keith","last_name":"Warfield","full_name":"Warfield, Keith"},{"full_name":"Cahoy, Kerri","first_name":"Kerri","last_name":"Cahoy"},{"full_name":"Clarke, John T.","last_name":"Clarke","first_name":"John T."},{"last_name":"Shawn Domagal-Goldman","first_name":"Shawn Domagal-Goldman","full_name":"Shawn Domagal-Goldman, Shawn Domagal-Goldman"},{"first_name":"Lee","last_name":"Feinberg","full_name":"Feinberg, Lee"},{"first_name":"Olivier","last_name":"Guyon","full_name":"Guyon, Olivier"},{"full_name":"Kasdin, Jeremy","last_name":"Kasdin","first_name":"Jeremy"},{"last_name":"Mawet","first_name":"Dimitri","full_name":"Mawet, Dimitri"},{"last_name":"Plavchan","first_name":"Peter","full_name":"Plavchan, Peter"},{"last_name":"Robinson","first_name":"Tyler","full_name":"Robinson, Tyler"},{"last_name":"Rogers","first_name":"Leslie","full_name":"Rogers, Leslie"},{"first_name":"Paul","last_name":"Scowen","full_name":"Scowen, Paul"},{"first_name":"Rachel","last_name":"Somerville","full_name":"Somerville, Rachel"},{"first_name":"Karl","last_name":"Stapelfeldt","full_name":"Stapelfeldt, Karl"},{"last_name":"Stark","first_name":"Christopher","full_name":"Stark, Christopher"},{"last_name":"Stern","first_name":"Daniel","full_name":"Stern, Daniel"},{"full_name":"Turnbull, Margaret","first_name":"Margaret","last_name":"Turnbull"},{"first_name":"Rashied","last_name":"Amini","full_name":"Amini, Rashied"},{"first_name":"Gary","last_name":"Kuan","full_name":"Kuan, Gary"},{"full_name":"Martin, Stefan","first_name":"Stefan","last_name":"Martin"},{"full_name":"Morgan, Rhonda","last_name":"Morgan","first_name":"Rhonda"},{"first_name":"David","last_name":"Redding","full_name":"Redding, David"},{"last_name":"Stahl","first_name":"H. Philip","full_name":"Stahl, H. Philip"},{"full_name":"Webb, Ryan","last_name":"Webb","first_name":"Ryan"},{"first_name":"Oscar Alvarez-Salazar","last_name":"Oscar Alvarez-Salazar","full_name":"Oscar Alvarez-Salazar, Oscar Alvarez-Salazar"},{"last_name":"Arnold","first_name":"William L.","full_name":"Arnold, William L."},{"first_name":"Manan","last_name":"Arya","full_name":"Arya, Manan"},{"first_name":"Bala","last_name":"Balasubramanian","full_name":"Balasubramanian, Bala"},{"first_name":"Mike","last_name":"Baysinger","full_name":"Baysinger, Mike"},{"last_name":"Bell","first_name":"Ray","full_name":"Bell, Ray"},{"first_name":"Chris","last_name":"Below","full_name":"Below, Chris"},{"first_name":"Jonathan","last_name":"Benson","full_name":"Benson, Jonathan"},{"full_name":"Blais, Lindsey","first_name":"Lindsey","last_name":"Blais"},{"full_name":"Booth, Jeff","first_name":"Jeff","last_name":"Booth"},{"first_name":"Robert","last_name":"Bourgeois","full_name":"Bourgeois, Robert"},{"first_name":"Case","last_name":"Bradford","full_name":"Bradford, Case"},{"last_name":"Brewer","first_name":"Alden","full_name":"Brewer, Alden"},{"last_name":"Brooks","first_name":"Thomas","full_name":"Brooks, Thomas"},{"first_name":"Eric","last_name":"Cady","full_name":"Cady, Eric"},{"last_name":"Caldwell","first_name":"Mary","full_name":"Caldwell, Mary"},{"full_name":"Calvet, Rob","last_name":"Calvet","first_name":"Rob"},{"last_name":"Carr","first_name":"Steven","full_name":"Carr, Steven"},{"full_name":"Chan, Derek","last_name":"Chan","first_name":"Derek"},{"last_name":"Cormarkovic","first_name":"Velibor","full_name":"Cormarkovic, Velibor"},{"full_name":"Coste, Keith","last_name":"Coste","first_name":"Keith"},{"full_name":"Cox, Charlie","last_name":"Cox","first_name":"Charlie"},{"last_name":"Danner","first_name":"Rolf","full_name":"Danner, Rolf"},{"full_name":"Davis, Jacqueline","first_name":"Jacqueline","last_name":"Davis"},{"full_name":"Dewell, Larry","last_name":"Dewell","first_name":"Larry"},{"first_name":"Lisa","last_name":"Dorsett","full_name":"Dorsett, Lisa"},{"last_name":"Dunn","first_name":"Daniel","full_name":"Dunn, Daniel"},{"full_name":"East, Matthew","first_name":"Matthew","last_name":"East"},{"full_name":"Effinger, Michael","first_name":"Michael","last_name":"Effinger"},{"first_name":"Ron","last_name":"Eng","full_name":"Eng, Ron"},{"last_name":"Freebury","first_name":"Greg","full_name":"Freebury, Greg"},{"full_name":"Garcia, Jay","first_name":"Jay","last_name":"Garcia"},{"full_name":"Gaskin, Jonathan","last_name":"Gaskin","first_name":"Jonathan"},{"full_name":"Greene, Suzan","first_name":"Suzan","last_name":"Greene"},{"first_name":"John","last_name":"Hennessy","full_name":"Hennessy, John"},{"first_name":"Evan","last_name":"Hilgemann","full_name":"Hilgemann, Evan"},{"full_name":"Hood, Brad","first_name":"Brad","last_name":"Hood"},{"last_name":"Holota","first_name":"Wolfgang","full_name":"Holota, Wolfgang"},{"full_name":"Howe, Scott","last_name":"Howe","first_name":"Scott"},{"full_name":"Huang, Pei","first_name":"Pei","last_name":"Huang"},{"first_name":"Tony","last_name":"Hull","full_name":"Hull, Tony"},{"full_name":"Hunt, Ron","last_name":"Hunt","first_name":"Ron"},{"last_name":"Hurd","first_name":"Kevin","full_name":"Hurd, Kevin"},{"first_name":"Sandra","last_name":"Johnson","full_name":"Johnson, Sandra"},{"first_name":"Andrew","last_name":"Kissil","full_name":"Kissil, Andrew"},{"first_name":"Brent","last_name":"Knight","full_name":"Knight, Brent"},{"last_name":"Kolenz","first_name":"Daniel","full_name":"Kolenz, Daniel"},{"full_name":"Kraus, Oliver","first_name":"Oliver","last_name":"Kraus"},{"full_name":"Krist, John","last_name":"Krist","first_name":"John"},{"full_name":"Li, Mary","last_name":"Li","first_name":"Mary"},{"first_name":"Doug","last_name":"Lisman","full_name":"Lisman, Doug"},{"full_name":"Mandic, Milan","first_name":"Milan","last_name":"Mandic"},{"full_name":"Mann, John","first_name":"John","last_name":"Mann"},{"full_name":"Marchen, Luis","last_name":"Marchen","first_name":"Luis"},{"full_name":"Colleen Marrese-Reading, Colleen Marrese-Reading","first_name":"Colleen Marrese-Reading","last_name":"Colleen Marrese-Reading"},{"full_name":"McCready, Jonathan","first_name":"Jonathan","last_name":"McCready"},{"first_name":"Jim","last_name":"McGown","full_name":"McGown, Jim"},{"full_name":"Missun, Jessica","last_name":"Missun","first_name":"Jessica"},{"full_name":"Miyaguchi, Andrew","first_name":"Andrew","last_name":"Miyaguchi"},{"full_name":"Moore, Bradley","first_name":"Bradley","last_name":"Moore"},{"full_name":"Nemati, Bijan","last_name":"Nemati","first_name":"Bijan"},{"full_name":"Nikzad, Shouleh","first_name":"Shouleh","last_name":"Nikzad"},{"last_name":"Nissen","first_name":"Joel","full_name":"Nissen, Joel"},{"full_name":"Novicki, Megan","first_name":"Megan","last_name":"Novicki"},{"full_name":"Perrine, Todd","last_name":"Perrine","first_name":"Todd"},{"full_name":"Pineda, Claudia","last_name":"Pineda","first_name":"Claudia"},{"first_name":"Otto","last_name":"Polanco","full_name":"Polanco, Otto"},{"full_name":"Putnam, Dustin","first_name":"Dustin","last_name":"Putnam"},{"full_name":"Qureshi, Atif","last_name":"Qureshi","first_name":"Atif"},{"full_name":"Richards, Michael","first_name":"Michael","last_name":"Richards"},{"first_name":"A. J. Eldorado","last_name":"Riggs","full_name":"Riggs, A. J. Eldorado"},{"full_name":"Rodgers, Michael","last_name":"Rodgers","first_name":"Michael"},{"full_name":"Rud, Mike","first_name":"Mike","last_name":"Rud"},{"full_name":"Saini, Navtej","first_name":"Navtej","last_name":"Saini"},{"full_name":"Scalisi, Dan","last_name":"Scalisi","first_name":"Dan"},{"last_name":"Scharf","first_name":"Dan","full_name":"Scharf, Dan"},{"first_name":"Kevin","last_name":"Schulz","full_name":"Schulz, Kevin"},{"full_name":"Serabyn, Gene","first_name":"Gene","last_name":"Serabyn"},{"full_name":"Sigrist, Norbert","last_name":"Sigrist","first_name":"Norbert"},{"last_name":"Sikkia","first_name":"Glory","full_name":"Sikkia, Glory"},{"full_name":"Singleton, Andrew","last_name":"Singleton","first_name":"Andrew"},{"full_name":"Shaklan, Stuart","last_name":"Shaklan","first_name":"Stuart"},{"first_name":"Scott","last_name":"Smith","full_name":"Smith, Scott"},{"last_name":"Southerd","first_name":"Bart","full_name":"Southerd, Bart"},{"full_name":"Stahl, Mark","last_name":"Stahl","first_name":"Mark"},{"first_name":"John","last_name":"Steeves","full_name":"Steeves, John"},{"first_name":"Brian","last_name":"Sturges","full_name":"Sturges, Brian"},{"last_name":"Sullivan","first_name":"Chris","full_name":"Sullivan, Chris"},{"full_name":"Tang, Hao","first_name":"Hao","last_name":"Tang"},{"first_name":"Neil","last_name":"Taras","full_name":"Taras, Neil"},{"full_name":"Tesch, Jonathan","last_name":"Tesch","first_name":"Jonathan"},{"first_name":"Melissa","last_name":"Therrell","full_name":"Therrell, Melissa"},{"first_name":"Howard","last_name":"Tseng","full_name":"Tseng, Howard"},{"full_name":"Valente, Marty","last_name":"Valente","first_name":"Marty"},{"first_name":"David Van","last_name":"Buren","full_name":"Buren, David Van"},{"full_name":"Villalvazo, Juan","first_name":"Juan","last_name":"Villalvazo"},{"last_name":"Warwick","first_name":"Steve","full_name":"Warwick, Steve"},{"full_name":"Webb, David","first_name":"David","last_name":"Webb"},{"full_name":"Westerhoff, Thomas","first_name":"Thomas","last_name":"Westerhoff"},{"full_name":"Wofford, Rush","first_name":"Rush","last_name":"Wofford"},{"first_name":"Gordon","last_name":"Wu","full_name":"Wu, Gordon"},{"first_name":"Jahning","last_name":"Woo","full_name":"Woo, Jahning"},{"full_name":"Wood, Milana","last_name":"Wood","first_name":"Milana"},{"full_name":"Ziemer, John","first_name":"John","last_name":"Ziemer"},{"full_name":"Arney, Giada","last_name":"Arney","first_name":"Giada"},{"full_name":"Anderson, Jay","first_name":"Jay","last_name":"Anderson"},{"first_name":"Jesús Maíz-Apellániz","last_name":"Jesús Maíz-Apellániz","full_name":"Jesús Maíz-Apellániz, Jesús Maíz-Apellániz"},{"full_name":"Bartlett, James","first_name":"James","last_name":"Bartlett"},{"first_name":"Ruslan","last_name":"Belikov","full_name":"Belikov, Ruslan"},{"full_name":"Bendek, Eduardo","first_name":"Eduardo","last_name":"Bendek"},{"last_name":"Cenko","first_name":"Brad","full_name":"Cenko, Brad"},{"full_name":"Douglas, Ewan","last_name":"Douglas","first_name":"Ewan"},{"full_name":"Dulz, Shannon","last_name":"Dulz","first_name":"Shannon"},{"last_name":"Evans","first_name":"Chris","full_name":"Evans, Chris"},{"first_name":"Virginie","last_name":"Faramaz","full_name":"Faramaz, Virginie"},{"last_name":"Feng","first_name":"Y. Katherina","full_name":"Feng, Y. Katherina"},{"first_name":"Harry","last_name":"Ferguson","full_name":"Ferguson, Harry"},{"first_name":"Kate","last_name":"Follette","full_name":"Follette, Kate"},{"first_name":"Saavik","last_name":"Ford","full_name":"Ford, Saavik"},{"full_name":"García, Miriam","first_name":"Miriam","last_name":"García"},{"full_name":"Geha, Marla","last_name":"Geha","first_name":"Marla"},{"first_name":"Dawn","last_name":"Gelino","full_name":"Gelino, Dawn"},{"orcid":"0000-0002-6960-6911","full_name":"Götberg, Ylva Louise Linsdotter","first_name":"Ylva Louise Linsdotter","last_name":"Götberg","id":"d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d"},{"full_name":"Hildebrandt, Sergi","first_name":"Sergi","last_name":"Hildebrandt"},{"full_name":"Hu, Renyu","last_name":"Hu","first_name":"Renyu"},{"first_name":"Knud","last_name":"Jahnke","full_name":"Jahnke, Knud"},{"full_name":"Kennedy, Grant","first_name":"Grant","last_name":"Kennedy"},{"full_name":"Kreidberg, Laura","first_name":"Laura","last_name":"Kreidberg"},{"full_name":"Isella, Andrea","first_name":"Andrea","last_name":"Isella"},{"last_name":"Lopez","first_name":"Eric","full_name":"Lopez, Eric"},{"last_name":"Marchis","first_name":"Franck","full_name":"Marchis, Franck"},{"last_name":"Macri","first_name":"Lucas","full_name":"Macri, Lucas"},{"full_name":"Marley, Mark","last_name":"Marley","first_name":"Mark"},{"full_name":"Matzko, William","last_name":"Matzko","first_name":"William"},{"first_name":"Johan","last_name":"Mazoyer","full_name":"Mazoyer, Johan"},{"full_name":"McCandliss, Stephan","first_name":"Stephan","last_name":"McCandliss"},{"last_name":"Meshkat","first_name":"Tiffany","full_name":"Meshkat, Tiffany"},{"full_name":"Mordasini, Christoph","first_name":"Christoph","last_name":"Mordasini"},{"full_name":"Morris, Patrick","last_name":"Morris","first_name":"Patrick"},{"full_name":"Nielsen, Eric","first_name":"Eric","last_name":"Nielsen"},{"full_name":"Newman, Patrick","first_name":"Patrick","last_name":"Newman"},{"full_name":"Petigura, Erik","last_name":"Petigura","first_name":"Erik"},{"full_name":"Postman, Marc","last_name":"Postman","first_name":"Marc"},{"full_name":"Reines, Amy","first_name":"Amy","last_name":"Reines"},{"last_name":"Roberge","first_name":"Aki","full_name":"Roberge, Aki"},{"full_name":"Roederer, Ian","first_name":"Ian","last_name":"Roederer"},{"full_name":"Ruane, Garreth","first_name":"Garreth","last_name":"Ruane"},{"full_name":"Schwieterman, Edouard","last_name":"Schwieterman","first_name":"Edouard"},{"last_name":"Sirbu","first_name":"Dan","full_name":"Sirbu, Dan"},{"full_name":"Spalding, Christopher","first_name":"Christopher","last_name":"Spalding"},{"full_name":"Teplitz, Harry","last_name":"Teplitz","first_name":"Harry"},{"full_name":"Tumlinson, Jason","last_name":"Tumlinson","first_name":"Jason"},{"last_name":"Turner","first_name":"Neal","full_name":"Turner, Neal"},{"full_name":"Werk, Jessica","first_name":"Jessica","last_name":"Werk"},{"last_name":"Wofford","first_name":"Aida","full_name":"Wofford, Aida"},{"last_name":"Wyatt","first_name":"Mark","full_name":"Wyatt, Mark"},{"full_name":"Young, Amber","last_name":"Young","first_name":"Amber"},{"first_name":"Rob","last_name":"Zellem","full_name":"Zellem, Rob"}],"oa":1,"oa_version":"Preprint","article_number":"2001.06683","extern":"1","day":"18","publication":"arXiv","status":"public","article_processing_charge":"No","title":"The habitable exoplanet observatory (HabEx) mission concept study final report","date_created":"2023-08-21T10:10:21Z","doi":"10.48550/arXiv.2001.06683","citation":{"ieee":"B. S. Gaudi <i>et al.</i>, “The habitable exoplanet observatory (HabEx) mission concept study final report,” <i>arXiv</i>. .","ista":"Gaudi BS et al. The habitable exoplanet observatory (HabEx) mission concept study final report. arXiv, 2001.06683.","ama":"Gaudi BS, Seager S, Mennesson B, et al. The habitable exoplanet observatory (HabEx) mission concept study final report. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2001.06683\">10.48550/arXiv.2001.06683</a>","apa":"Gaudi, B. S., Seager, S., Mennesson, B., Kiessling, A., Warfield, K., Cahoy, K., … Zellem, R. (n.d.). The habitable exoplanet observatory (HabEx) mission concept study final report. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2001.06683\">https://doi.org/10.48550/arXiv.2001.06683</a>","chicago":"Gaudi, B. Scott, Sara Seager, Bertrand Mennesson, Alina Kiessling, Keith Warfield, Kerri Cahoy, John T. Clarke, et al. “The Habitable Exoplanet Observatory (HabEx) Mission Concept Study Final Report.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2001.06683\">https://doi.org/10.48550/arXiv.2001.06683</a>.","short":"B.S. Gaudi, S. Seager, B. Mennesson, A. Kiessling, K. Warfield, K. Cahoy, J.T. Clarke, S.D.-G. Shawn Domagal-Goldman, L. Feinberg, O. Guyon, J. Kasdin, D. Mawet, P. Plavchan, T. Robinson, L. Rogers, P. Scowen, R. Somerville, K. Stapelfeldt, C. Stark, D. Stern, M. Turnbull, R. Amini, G. Kuan, S. Martin, R. Morgan, D. Redding, H.P. Stahl, R. Webb, O.A.-S. Oscar Alvarez-Salazar, W.L. Arnold, M. Arya, B. Balasubramanian, M. Baysinger, R. Bell, C. Below, J. Benson, L. Blais, J. Booth, R. Bourgeois, C. Bradford, A. Brewer, T. Brooks, E. Cady, M. Caldwell, R. Calvet, S. Carr, D. Chan, V. Cormarkovic, K. Coste, C. Cox, R. Danner, J. Davis, L. Dewell, L. Dorsett, D. Dunn, M. East, M. Effinger, R. Eng, G. Freebury, J. Garcia, J. Gaskin, S. Greene, J. Hennessy, E. Hilgemann, B. Hood, W. Holota, S. Howe, P. Huang, T. Hull, R. Hunt, K. Hurd, S. Johnson, A. Kissil, B. Knight, D. Kolenz, O. Kraus, J. Krist, M. Li, D. Lisman, M. Mandic, J. Mann, L. Marchen, C.M.-R. Colleen Marrese-Reading, J. McCready, J. McGown, J. Missun, A. Miyaguchi, B. Moore, B. Nemati, S. Nikzad, J. Nissen, M. Novicki, T. Perrine, C. Pineda, O. Polanco, D. Putnam, A. Qureshi, M. Richards, A.J.E. Riggs, M. Rodgers, M. Rud, N. Saini, D. Scalisi, D. Scharf, K. Schulz, G. Serabyn, N. Sigrist, G. Sikkia, A. Singleton, S. Shaklan, S. Smith, B. Southerd, M. Stahl, J. Steeves, B. Sturges, C. Sullivan, H. Tang, N. Taras, J. Tesch, M. Therrell, H. Tseng, M. Valente, D.V. Buren, J. Villalvazo, S. Warwick, D. Webb, T. Westerhoff, R. Wofford, G. Wu, J. Woo, M. Wood, J. Ziemer, G. Arney, J. Anderson, J.M.-A. Jesús Maíz-Apellániz, J. Bartlett, R. Belikov, E. Bendek, B. Cenko, E. Douglas, S. Dulz, C. Evans, V. Faramaz, Y.K. Feng, H. Ferguson, K. Follette, S. Ford, M. García, M. Geha, D. Gelino, Y.L.L. Götberg, S. Hildebrandt, R. Hu, K. Jahnke, G. Kennedy, L. Kreidberg, A. Isella, E. Lopez, F. Marchis, L. Macri, M. Marley, W. Matzko, J. Mazoyer, S. McCandliss, T. Meshkat, C. Mordasini, P. Morris, E. Nielsen, P. Newman, E. Petigura, M. Postman, A. Reines, A. Roberge, I. Roederer, G. Ruane, E. Schwieterman, D. Sirbu, C. Spalding, H. Teplitz, J. Tumlinson, N. Turner, J. Werk, A. Wofford, M. Wyatt, A. Young, R. Zellem, ArXiv (n.d.).","mla":"Gaudi, B. Scott, et al. “The Habitable Exoplanet Observatory (HabEx) Mission Concept Study Final Report.” <i>ArXiv</i>, 2001.06683, doi:<a href=\"https://doi.org/10.48550/arXiv.2001.06683\">10.48550/arXiv.2001.06683</a>."},"date_updated":"2023-08-22T13:13:18Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2001.06683"}],"arxiv":1,"abstract":[{"text":"The Habitable Exoplanet Observatory, or HabEx, has been designed to be the Great Observatory of the 2030s. For the first time in human history, technologies have matured sufficiently to enable an affordable space-based telescope mission capable of discovering and characterizing Earthlike planets orbiting nearby bright sunlike stars in order to search for signs of habitability and biosignatures. Such a mission can also be equipped with instrumentation that will enable broad and exciting general astrophysics and planetary science not possible from current or planned facilities. HabEx is a space telescope with unique imaging and multi-object spectroscopic capabilities at wavelengths ranging from ultraviolet (UV) to near-IR. These capabilities allow for a broad suite of compelling science that cuts across the entire NASA astrophysics portfolio. HabEx has three primary science goals: (1) Seek out nearby worlds and explore their habitability; (2) Map out nearby planetary systems and understand the diversity of the worlds they contain; (3) Enable new explorations of astrophysical systems from our own solar system to external galaxies by extending our reach in the UV through near-IR. This Great Observatory science will be selected through a competed GO program, and will account for about 50% of the HabEx primary mission. The preferred HabEx architecture is a 4m, monolithic, off-axis telescope that is diffraction-limited at 0.4 microns and is in an L2 orbit. HabEx employs two starlight suppression systems: a coronagraph and a starshade, each with their own dedicated instrument.","lang":"eng"}],"publication_status":"submitted","_id":"14095","date_published":"2020-01-18T00:00:00Z","type":"preprint","language":[{"iso":"eng"}],"month":"01"},{"year":"2020","external_id":{"arxiv":["2011.06630"]},"author":[{"full_name":"Jamie A. P. Law-Smith, Jamie A. P. Law-Smith","first_name":"Jamie A. P. Law-Smith","last_name":"Jamie A. P. Law-Smith"},{"first_name":"Rosa Wallace","last_name":"Everson","full_name":"Everson, Rosa Wallace"},{"last_name":"Enrico Ramirez-Ruiz","first_name":"Enrico Ramirez-Ruiz","full_name":"Enrico Ramirez-Ruiz, Enrico Ramirez-Ruiz"},{"full_name":"Mink, Selma E. de","last_name":"Mink","first_name":"Selma E. de"},{"full_name":"Son, Lieke A. C. van","first_name":"Lieke A. C. van","last_name":"Son"},{"last_name":"Götberg","id":"d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d","first_name":"Ylva Louise Linsdotter","full_name":"Götberg, Ylva Louise Linsdotter","orcid":"0000-0002-6960-6911"},{"last_name":"Zellmann","first_name":"Stefan","full_name":"Zellmann, Stefan"},{"full_name":"Alejandro Vigna-Gómez, Alejandro Vigna-Gómez","first_name":"Alejandro Vigna-Gómez","last_name":"Alejandro Vigna-Gómez"},{"full_name":"Renzo, Mathieu","last_name":"Renzo","first_name":"Mathieu"},{"last_name":"Wu","first_name":"Samantha","full_name":"Wu, Samantha"},{"last_name":"Schrøder","first_name":"Sophie L.","full_name":"Schrøder, Sophie L."},{"full_name":"Foley, Ryan J.","last_name":"Foley","first_name":"Ryan J."},{"full_name":"Tenley Hutchinson-Smith, Tenley Hutchinson-Smith","first_name":"Tenley Hutchinson-Smith","last_name":"Tenley Hutchinson-Smith"}],"oa_version":"Preprint","oa":1,"article_number":"2011.06630","extern":"1","day":"12","article_processing_charge":"No","publication":"arXiv","status":"public","title":"Successful common envelope ejection and binary neutron star formation in 3D hydrodynamics","date_created":"2023-08-21T10:10:41Z","citation":{"short":"J.A.P.L.-S. Jamie A. P. Law-Smith, R.W. Everson, E.R.-R. Enrico Ramirez-Ruiz, S.E. de Mink, L.A.C. van Son, Y.L.L. Götberg, S. Zellmann, A.V.-G. Alejandro Vigna-Gómez, M. Renzo, S. Wu, S.L. Schrøder, R.J. Foley, T.H.-S. Tenley Hutchinson-Smith, ArXiv (n.d.).","mla":"Jamie A. P. Law-Smith, Jamie A. P. Law-Smith, et al. “Successful Common Envelope Ejection and Binary Neutron Star Formation in 3D Hydrodynamics.” <i>ArXiv</i>, 2011.06630, doi:<a href=\"https://doi.org/10.48550/arXiv.2011.06630\">10.48550/arXiv.2011.06630</a>.","chicago":"Jamie A. P. Law-Smith, Jamie A. P. Law-Smith, Rosa Wallace Everson, Enrico Ramirez-Ruiz Enrico Ramirez-Ruiz, Selma E. de Mink, Lieke A. C. van Son, Ylva Louise Linsdotter Götberg, Stefan Zellmann, et al. “Successful Common Envelope Ejection and Binary Neutron Star Formation in 3D Hydrodynamics.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.2011.06630\">https://doi.org/10.48550/arXiv.2011.06630</a>.","apa":"Jamie A. P. Law-Smith, J. A. P. L.-S., Everson, R. W., Enrico Ramirez-Ruiz, E. R.-R., Mink, S. E. de, Son, L. A. C. van, Götberg, Y. L. L., … Tenley Hutchinson-Smith, T. H.-S. (n.d.). Successful common envelope ejection and binary neutron star formation in 3D hydrodynamics. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.2011.06630\">https://doi.org/10.48550/arXiv.2011.06630</a>","ieee":"J. A. P. L.-S. Jamie A. P. Law-Smith <i>et al.</i>, “Successful common envelope ejection and binary neutron star formation in 3D hydrodynamics,” <i>arXiv</i>. .","ama":"Jamie A. P. Law-Smith JAPL-S, Everson RW, Enrico Ramirez-Ruiz ER-R, et al. Successful common envelope ejection and binary neutron star formation in 3D hydrodynamics. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.2011.06630\">10.48550/arXiv.2011.06630</a>","ista":"Jamie A. P. Law-Smith JAPL-S, Everson RW, Enrico Ramirez-Ruiz ER-R, Mink SE de, Son LAC van, Götberg YLL, Zellmann S, Alejandro Vigna-Gómez AV-G, Renzo M, Wu S, Schrøder SL, Foley RJ, Tenley Hutchinson-Smith TH-S. Successful common envelope ejection and binary neutron star formation in 3D hydrodynamics. arXiv, 2011.06630."},"doi":"10.48550/arXiv.2011.06630","date_updated":"2025-01-14T14:22:04Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2011.06630"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","arxiv":1,"abstract":[{"text":"A binary neutron star merger has been observed in a multi-messenger detection of gravitational wave (GW) and electromagnetic (EM) radiation. Binary neutron stars that merge within a Hubble time, as well as many other compact binaries, are expected to form via common envelope evolution. Yet five decades of research on common envelope evolution have not yet resulted in a satisfactory understanding of the multi-spatial multi-timescale evolution for the systems that lead to compact binaries. In this paper, we report on the first successful simulations of common envelope ejection leading to binary neutron star formation in 3D hydrodynamics. We simulate the dynamical inspiral phase of the interaction between a 12M⊙ red supergiant and a 1.4M⊙ neutron star for different initial separations and initial conditions. For all of our simulations, we find complete envelope ejection and final orbital separations of af≈1.3-5.1R⊙ depending on the simulation and criterion, leading to binary neutron stars that can merge within a Hubble time. We find αCE-equivalent efficiencies of ≈0.1-2.7 depending on the simulation and criterion, but this may be specific for these extended progenitors. We fully resolve the core of the star to ≲0.005R⊙ and our 3D hydrodynamics simulations are informed by an adjusted 1D analytic energy formalism and a 2D kinematics study in order to overcome the prohibitive computational cost of simulating these systems. The framework we develop in this paper can be used to simulate a wide variety of interactions between stars, from stellar mergers to common envelope episodes leading to GW sources.","lang":"eng"}],"publication_status":"submitted","_id":"14096","date_published":"2020-11-12T00:00:00Z","type":"preprint","language":[{"iso":"eng"}],"month":"11"},{"date_updated":"2023-09-11T10:21:00Z","citation":{"mla":"Stark, Stefan G., et al. “SCIM: Universal Single-Cell Matching with Unpaired Feature Sets.” <i>Bioinformatics</i>, vol. 36, no. Supplement_2, Oxford University Press, 2020, pp. i919–27, doi:<a href=\"https://doi.org/10.1093/bioinformatics/btaa843\">10.1093/bioinformatics/btaa843</a>.","short":"S.G. Stark, J. Ficek, F. Locatello, X. Bonilla, S. Chevrier, F. Singer, R. Aebersold, F.S. Al-Quaddoomi, J. Albinus, I. Alborelli, S. Andani, P.-O. Attinger, M. Bacac, D. Baumhoer, B. Beck-Schimmer, N. Beerenwinkel, C. Beisel, L. Bernasconi, A. Bertolini, B. Bodenmiller, X. Bonilla, R. Casanova, S. Chevrier, N. Chicherova, M. D’Costa, E. Danenberg, N. Davidson, M.-A.D. gan, R. Dummer, S. Engler, M. Erkens, K. Eschbach, C. Esposito, A. Fedier, P. Ferreira, J. Ficek, A.L. Frei, B. Frey, S. Goetze, L. Grob, G. Gut, D. Günther, M. Haberecker, P. Haeuptle, V. Heinzelmann-Schwarz, S. Herter, R. Holtackers, T. Huesser, A. Irmisch, F. Jacob, A. Jacobs, T.M. Jaeger, K. Jahn, A.R. James, P.M. Jermann, A. Kahles, A. Kahraman, V.H. Koelzer, W. Kuebler, J. Kuipers, C.P. Kunze, C. Kurzeder, K.-V. Lehmann, M. Levesque, S. Lugert, G. Maass, M. Manz, P. Markolin, J. Mena, U. Menzel, J.M. Metzler, N. Miglino, E.S. Milani, H. Moch, S. Muenst, R. Murri, C.K. Ng, S. Nicolet, M. Nowak, P.G. Pedrioli, L. Pelkmans, S. Piscuoglio, M. Prummer, M. Ritter, C. Rommel, M.L. Rosano-González, G. Rätsch, N. Santacroce, J.S. del Castillo, R. Schlenker, P.C. Schwalie, S. Schwan, T. Schär, G. Senti, F. Singer, S. Sivapatham, B. Snijder, B. Sobottka, V.T. Sreedharan, S. Stark, D.J. Stekhoven, A.P. Theocharides, T.M. Thomas, M. Tolnay, V. Tosevski, N.C. Toussaint, M.A. Tuncel, M. Tusup, A.V. Drogen, M. Vetter, T. Vlajnic, S. Weber, W.P. Weber, R. Wegmann, M. Weller, F. Wendt, N. Wey, A. Wicki, B. Wollscheid, S. Yu, J. Ziegler, M. Zimmermann, M. Zoche, G. Zuend, G. Rätsch, K.-V. Lehmann, Bioinformatics 36 (2020) i919–i927.","chicago":"Stark, Stefan G, Joanna Ficek, Francesco Locatello, Ximena Bonilla, Stéphane Chevrier, Franziska Singer, Rudolf Aebersold, et al. “SCIM: Universal Single-Cell Matching with Unpaired Feature Sets.” <i>Bioinformatics</i>. Oxford University Press, 2020. <a href=\"https://doi.org/10.1093/bioinformatics/btaa843\">https://doi.org/10.1093/bioinformatics/btaa843</a>.","apa":"Stark, S. G., Ficek, J., Locatello, F., Bonilla, X., Chevrier, S., Singer, F., … Lehmann, K.-V. (2020). SCIM: Universal single-cell matching with unpaired feature sets. <i>Bioinformatics</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/bioinformatics/btaa843\">https://doi.org/10.1093/bioinformatics/btaa843</a>","ista":"Stark SG et al. 2020. SCIM: Universal single-cell matching with unpaired feature sets. Bioinformatics. 36(Supplement_2), i919–i927.","ieee":"S. G. Stark <i>et al.</i>, “SCIM: Universal single-cell matching with unpaired feature sets,” <i>Bioinformatics</i>, vol. 36, no. Supplement_2. Oxford University Press, pp. i919–i927, 2020.","ama":"Stark SG, Ficek J, Locatello F, et al. SCIM: Universal single-cell matching with unpaired feature sets. <i>Bioinformatics</i>. 2020;36(Supplement_2):i919-i927. doi:<a href=\"https://doi.org/10.1093/bioinformatics/btaa843\">10.1093/bioinformatics/btaa843</a>"},"date_published":"2020-12-01T00:00:00Z","quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","intvolume":"        36","author":[{"first_name":"Stefan G","last_name":"Stark","full_name":"Stark, Stefan G"},{"full_name":"Ficek, Joanna","first_name":"Joanna","last_name":"Ficek"},{"id":"26cfd52f-2483-11ee-8040-88983bcc06d4","last_name":"Locatello","first_name":"Francesco","orcid":"0000-0002-4850-0683","full_name":"Locatello, Francesco"},{"full_name":"Bonilla, Ximena","last_name":"Bonilla","first_name":"Ximena"},{"first_name":"Stéphane","last_name":"Chevrier","full_name":"Chevrier, Stéphane"},{"first_name":"Franziska","last_name":"Singer","full_name":"Singer, Franziska"},{"first_name":"Rudolf","last_name":"Aebersold","full_name":"Aebersold, Rudolf"},{"first_name":"Faisal S","last_name":"Al-Quaddoomi","full_name":"Al-Quaddoomi, Faisal S"},{"last_name":"Albinus","first_name":"Jonas","full_name":"Albinus, Jonas"},{"last_name":"Alborelli","first_name":"Ilaria","full_name":"Alborelli, Ilaria"},{"last_name":"Andani","first_name":"Sonali","full_name":"Andani, Sonali"},{"last_name":"Attinger","first_name":"Per-Olof","full_name":"Attinger, Per-Olof"},{"full_name":"Bacac, Marina","last_name":"Bacac","first_name":"Marina"},{"last_name":"Baumhoer","first_name":"Daniel","full_name":"Baumhoer, Daniel"},{"full_name":"Beck-Schimmer, Beatrice","last_name":"Beck-Schimmer","first_name":"Beatrice"},{"first_name":"Niko","last_name":"Beerenwinkel","full_name":"Beerenwinkel, Niko"},{"full_name":"Beisel, Christian","first_name":"Christian","last_name":"Beisel"},{"first_name":"Lara","last_name":"Bernasconi","full_name":"Bernasconi, Lara"},{"last_name":"Bertolini","first_name":"Anne","full_name":"Bertolini, Anne"},{"first_name":"Bernd","last_name":"Bodenmiller","full_name":"Bodenmiller, Bernd"},{"full_name":"Bonilla, Ximena","first_name":"Ximena","last_name":"Bonilla"},{"full_name":"Casanova, Ruben","last_name":"Casanova","first_name":"Ruben"},{"full_name":"Chevrier, Stéphane","first_name":"Stéphane","last_name":"Chevrier"},{"last_name":"Chicherova","first_name":"Natalia","full_name":"Chicherova, Natalia"},{"last_name":"D'Costa","first_name":"Maya","full_name":"D'Costa, Maya"},{"first_name":"Esther","last_name":"Danenberg","full_name":"Danenberg, Esther"},{"first_name":"Natalie","last_name":"Davidson","full_name":"Davidson, Natalie"},{"last_name":"gan","first_name":"Monica-Andreea Dră","full_name":"gan, Monica-Andreea Dră"},{"last_name":"Dummer","first_name":"Reinhard","full_name":"Dummer, Reinhard"},{"last_name":"Engler","first_name":"Stefanie","full_name":"Engler, Stefanie"},{"last_name":"Erkens","first_name":"Martin","full_name":"Erkens, Martin"},{"first_name":"Katja","last_name":"Eschbach","full_name":"Eschbach, Katja"},{"last_name":"Esposito","first_name":"Cinzia","full_name":"Esposito, Cinzia"},{"full_name":"Fedier, André","first_name":"André","last_name":"Fedier"},{"first_name":"Pedro","last_name":"Ferreira","full_name":"Ferreira, Pedro"},{"last_name":"Ficek","first_name":"Joanna","full_name":"Ficek, Joanna"},{"full_name":"Frei, Anja L","first_name":"Anja L","last_name":"Frei"},{"first_name":"Bruno","last_name":"Frey","full_name":"Frey, Bruno"},{"last_name":"Goetze","first_name":"Sandra","full_name":"Goetze, Sandra"},{"full_name":"Grob, Linda","last_name":"Grob","first_name":"Linda"},{"full_name":"Gut, Gabriele","first_name":"Gabriele","last_name":"Gut"},{"last_name":"Günther","first_name":"Detlef","full_name":"Günther, Detlef"},{"last_name":"Haberecker","first_name":"Martina","full_name":"Haberecker, Martina"},{"last_name":"Haeuptle","first_name":"Pirmin","full_name":"Haeuptle, Pirmin"},{"full_name":"Heinzelmann-Schwarz, Viola","last_name":"Heinzelmann-Schwarz","first_name":"Viola"},{"first_name":"Sylvia","last_name":"Herter","full_name":"Herter, Sylvia"},{"first_name":"Rene","last_name":"Holtackers","full_name":"Holtackers, Rene"},{"first_name":"Tamara","last_name":"Huesser","full_name":"Huesser, Tamara"},{"first_name":"Anja","last_name":"Irmisch","full_name":"Irmisch, Anja"},{"full_name":"Jacob, Francis","last_name":"Jacob","first_name":"Francis"},{"first_name":"Andrea","last_name":"Jacobs","full_name":"Jacobs, Andrea"},{"last_name":"Jaeger","first_name":"Tim M","full_name":"Jaeger, Tim M"},{"last_name":"Jahn","first_name":"Katharina","full_name":"Jahn, Katharina"},{"full_name":"James, Alva R","last_name":"James","first_name":"Alva R"},{"first_name":"Philip M","last_name":"Jermann","full_name":"Jermann, Philip M"},{"full_name":"Kahles, André","first_name":"André","last_name":"Kahles"},{"full_name":"Kahraman, Abdullah","first_name":"Abdullah","last_name":"Kahraman"},{"first_name":"Viktor H","last_name":"Koelzer","full_name":"Koelzer, Viktor H"},{"last_name":"Kuebler","first_name":"Werner","full_name":"Kuebler, Werner"},{"full_name":"Kuipers, Jack","last_name":"Kuipers","first_name":"Jack"},{"last_name":"Kunze","first_name":"Christian P","full_name":"Kunze, Christian P"},{"first_name":"Christian","last_name":"Kurzeder","full_name":"Kurzeder, Christian"},{"first_name":"Kjong-Van","last_name":"Lehmann","full_name":"Lehmann, Kjong-Van"},{"last_name":"Levesque","first_name":"Mitchell","full_name":"Levesque, Mitchell"},{"full_name":"Lugert, Sebastian","first_name":"Sebastian","last_name":"Lugert"},{"full_name":"Maass, Gerd","last_name":"Maass","first_name":"Gerd"},{"full_name":"Manz, Markus","first_name":"Markus","last_name":"Manz"},{"full_name":"Markolin, Philipp","last_name":"Markolin","first_name":"Philipp"},{"full_name":"Mena, Julien","last_name":"Mena","first_name":"Julien"},{"full_name":"Menzel, Ulrike","first_name":"Ulrike","last_name":"Menzel"},{"full_name":"Metzler, Julian M","last_name":"Metzler","first_name":"Julian M"},{"full_name":"Miglino, Nicola","last_name":"Miglino","first_name":"Nicola"},{"first_name":"Emanuela S","last_name":"Milani","full_name":"Milani, Emanuela S"},{"first_name":"Holger","last_name":"Moch","full_name":"Moch, Holger"},{"first_name":"Simone","last_name":"Muenst","full_name":"Muenst, Simone"},{"full_name":"Murri, Riccardo","last_name":"Murri","first_name":"Riccardo"},{"last_name":"Ng","first_name":"Charlotte KY","full_name":"Ng, Charlotte KY"},{"first_name":"Stefan","last_name":"Nicolet","full_name":"Nicolet, Stefan"},{"full_name":"Nowak, Marta","last_name":"Nowak","first_name":"Marta"},{"full_name":"Pedrioli, Patrick GA","first_name":"Patrick GA","last_name":"Pedrioli"},{"full_name":"Pelkmans, Lucas","last_name":"Pelkmans","first_name":"Lucas"},{"full_name":"Piscuoglio, Salvatore","first_name":"Salvatore","last_name":"Piscuoglio"},{"first_name":"Michael","last_name":"Prummer","full_name":"Prummer, Michael"},{"last_name":"Ritter","first_name":"Mathilde","full_name":"Ritter, Mathilde"},{"full_name":"Rommel, Christian","last_name":"Rommel","first_name":"Christian"},{"full_name":"Rosano-González, María L","first_name":"María L","last_name":"Rosano-González"},{"full_name":"Rätsch, Gunnar","first_name":"Gunnar","last_name":"Rätsch"},{"full_name":"Santacroce, Natascha","last_name":"Santacroce","first_name":"Natascha"},{"full_name":"Castillo, Jacobo Sarabia del","last_name":"Castillo","first_name":"Jacobo Sarabia del"},{"full_name":"Schlenker, Ramona","last_name":"Schlenker","first_name":"Ramona"},{"full_name":"Schwalie, Petra C","last_name":"Schwalie","first_name":"Petra C"},{"first_name":"Severin","last_name":"Schwan","full_name":"Schwan, Severin"},{"full_name":"Schär, Tobias","first_name":"Tobias","last_name":"Schär"},{"first_name":"Gabriela","last_name":"Senti","full_name":"Senti, Gabriela"},{"first_name":"Franziska","last_name":"Singer","full_name":"Singer, Franziska"},{"first_name":"Sujana","last_name":"Sivapatham","full_name":"Sivapatham, Sujana"},{"full_name":"Snijder, Berend","last_name":"Snijder","first_name":"Berend"},{"full_name":"Sobottka, Bettina","first_name":"Bettina","last_name":"Sobottka"},{"full_name":"Sreedharan, Vipin T","first_name":"Vipin T","last_name":"Sreedharan"},{"full_name":"Stark, Stefan","first_name":"Stefan","last_name":"Stark"},{"full_name":"Stekhoven, Daniel J","last_name":"Stekhoven","first_name":"Daniel J"},{"last_name":"Theocharides","first_name":"Alexandre PA","full_name":"Theocharides, Alexandre PA"},{"first_name":"Tinu M","last_name":"Thomas","full_name":"Thomas, Tinu M"},{"first_name":"Markus","last_name":"Tolnay","full_name":"Tolnay, Markus"},{"full_name":"Tosevski, Vinko","first_name":"Vinko","last_name":"Tosevski"},{"first_name":"Nora C","last_name":"Toussaint","full_name":"Toussaint, Nora C"},{"full_name":"Tuncel, Mustafa A","first_name":"Mustafa A","last_name":"Tuncel"},{"full_name":"Tusup, Marina","last_name":"Tusup","first_name":"Marina"},{"last_name":"Drogen","first_name":"Audrey Van","full_name":"Drogen, Audrey Van"},{"full_name":"Vetter, Marcus","first_name":"Marcus","last_name":"Vetter"},{"first_name":"Tatjana","last_name":"Vlajnic","full_name":"Vlajnic, Tatjana"},{"first_name":"Sandra","last_name":"Weber","full_name":"Weber, Sandra"},{"last_name":"Weber","first_name":"Walter P","full_name":"Weber, Walter P"},{"full_name":"Wegmann, Rebekka","last_name":"Wegmann","first_name":"Rebekka"},{"full_name":"Weller, Michael","last_name":"Weller","first_name":"Michael"},{"first_name":"Fabian","last_name":"Wendt","full_name":"Wendt, Fabian"},{"last_name":"Wey","first_name":"Norbert","full_name":"Wey, Norbert"},{"first_name":"Andreas","last_name":"Wicki","full_name":"Wicki, Andreas"},{"full_name":"Wollscheid, Bernd","last_name":"Wollscheid","first_name":"Bernd"},{"full_name":"Yu, Shuqing","first_name":"Shuqing","last_name":"Yu"},{"full_name":"Ziegler, Johanna","last_name":"Ziegler","first_name":"Johanna"},{"first_name":"Marc","last_name":"Zimmermann","full_name":"Zimmermann, Marc"},{"first_name":"Martin","last_name":"Zoche","full_name":"Zoche, Martin"},{"last_name":"Zuend","first_name":"Gregor","full_name":"Zuend, Gregor"},{"last_name":"Rätsch","first_name":"Gunnar","full_name":"Rätsch, Gunnar"},{"full_name":"Lehmann, Kjong-Van","last_name":"Lehmann","first_name":"Kjong-Van"}],"external_id":{"pmid":["33381818"]},"publisher":"Oxford University Press","article_type":"original","publication_identifier":{"eissn":["1367-4811"]},"status":"public","article_processing_charge":"No","day":"01","related_material":{"link":[{"url":"https://github.com/ratschlab/scim","relation":"software"}]},"date_created":"2023-08-21T12:28:20Z","department":[{"_id":"FrLo"}],"abstract":[{"text":"Motivation: Recent technological advances have led to an increase in the production and availability of single-cell data. The ability to integrate a set of multi-technology measurements would allow the identification of biologically or clinically meaningful observations through the unification of the perspectives afforded by each technology. In most cases, however, profiling technologies consume the used cells and thus pairwise correspondences between datasets are lost. Due to the sheer size single-cell datasets can acquire, scalable algorithms that are able to universally match single-cell measurements carried out in one cell to its corresponding sibling in another technology are needed.\r\nResults: We propose Single-Cell data Integration via Matching (SCIM), a scalable approach to recover such correspondences in two or more technologies. SCIM assumes that cells share a common (low-dimensional) underlying structure and that the underlying cell distribution is approximately constant across technologies. It constructs a technology-invariant latent space using an autoencoder framework with an adversarial objective. Multi-modal datasets are integrated by pairing cells across technologies using a bipartite matching scheme that operates on the low-dimensional latent representations. We evaluate SCIM on a simulated cellular branching process and show that the cell-to-cell matches derived by SCIM reflect the same pseudotime on the simulated dataset. Moreover, we apply our method to two real-world scenarios, a melanoma tumor sample and a human bone marrow sample, where we pair cells from a scRNA dataset to their sibling cells in a CyTOF dataset achieving 90% and 78% cell-matching accuracy for each one of the samples, respectively.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://doi.org/10.1093/bioinformatics/btaa843","open_access":"1"}],"keyword":["Computational Mathematics","Computational Theory and Mathematics","Computer Science Applications","Molecular Biology","Biochemistry","Statistics and Probability"],"scopus_import":"1","doi":"10.1093/bioinformatics/btaa843","issue":"Supplement_2","_id":"14125","page":"i919-i927","pmid":1,"publication_status":"published","month":"12","year":"2020","oa_version":"Published Version","oa":1,"publication":"Bioinformatics","extern":"1","title":"SCIM: Universal single-cell matching with unpaired feature sets","volume":36},{"intvolume":"        34","language":[{"iso":"eng"}],"type":"conference","date_published":"2020-07-28T00:00:00Z","quality_controlled":"1","citation":{"apa":"Locatello, F., Bauer, S., Lucic, M., Rätsch, G., Gelly, S., Schölkopf, B., &#38; Bachem, O. (2020). A commentary on the unsupervised learning of disentangled representations. In <i>The 34th AAAI Conference on Artificial Intelligence</i> (Vol. 34, pp. 13681–13684). New York, NY, United States: Association for the Advancement of Artificial Intelligence. <a href=\"https://doi.org/10.1609/aaai.v34i09.7120\">https://doi.org/10.1609/aaai.v34i09.7120</a>","chicago":"Locatello, Francesco, Stefan Bauer, Mario Lucic, Gunnar Rätsch, Sylvain Gelly, Bernhard Schölkopf, and Olivier Bachem. “A Commentary on the Unsupervised Learning of Disentangled Representations.” In <i>The 34th AAAI Conference on Artificial Intelligence</i>, 34:13681–84. Association for the Advancement of Artificial Intelligence, 2020. <a href=\"https://doi.org/10.1609/aaai.v34i09.7120\">https://doi.org/10.1609/aaai.v34i09.7120</a>.","short":"F. Locatello, S. Bauer, M. Lucic, G. Rätsch, S. Gelly, B. Schölkopf, O. Bachem, in:, The 34th AAAI Conference on Artificial Intelligence, Association for the Advancement of Artificial Intelligence, 2020, pp. 13681–13684.","mla":"Locatello, Francesco, et al. “A Commentary on the Unsupervised Learning of Disentangled Representations.” <i>The 34th AAAI Conference on Artificial Intelligence</i>, vol. 34, no. 9, Association for the Advancement of Artificial Intelligence, 2020, pp. 13681–84, doi:<a href=\"https://doi.org/10.1609/aaai.v34i09.7120\">10.1609/aaai.v34i09.7120</a>.","ama":"Locatello F, Bauer S, Lucic M, et al. A commentary on the unsupervised learning of disentangled representations. In: <i>The 34th AAAI Conference on Artificial Intelligence</i>. Vol 34. Association for the Advancement of Artificial Intelligence; 2020:13681-13684. doi:<a href=\"https://doi.org/10.1609/aaai.v34i09.7120\">10.1609/aaai.v34i09.7120</a>","ista":"Locatello F, Bauer S, Lucic M, Rätsch G, Gelly S, Schölkopf B, Bachem O. 2020. A commentary on the unsupervised learning of disentangled representations. The 34th AAAI Conference on Artificial Intelligence. AAAI: Conference on Artificial Intelligence vol. 34, 13681–13684.","ieee":"F. Locatello <i>et al.</i>, “A commentary on the unsupervised learning of disentangled representations,” in <i>The 34th AAAI Conference on Artificial Intelligence</i>, New York, NY, United States, 2020, vol. 34, no. 9, pp. 13681–13684."},"date_updated":"2023-09-12T07:44:48Z","conference":{"name":"AAAI: Conference on Artificial Intelligence","location":"New York, NY, United States","end_date":"2020-02-12","start_date":"2020-02-07"},"department":[{"_id":"FrLo"}],"date_created":"2023-08-22T14:07:26Z","publication_identifier":{"isbn":["9781577358350"],"eissn":["2374-3468"]},"status":"public","article_processing_charge":"No","day":"28","author":[{"full_name":"Locatello, Francesco","orcid":"0000-0002-4850-0683","first_name":"Francesco","last_name":"Locatello","id":"26cfd52f-2483-11ee-8040-88983bcc06d4"},{"first_name":"Stefan","last_name":"Bauer","full_name":"Bauer, Stefan"},{"last_name":"Lucic","first_name":"Mario","full_name":"Lucic, Mario"},{"full_name":"Rätsch, Gunnar","first_name":"Gunnar","last_name":"Rätsch"},{"last_name":"Gelly","first_name":"Sylvain","full_name":"Gelly, Sylvain"},{"first_name":"Bernhard","last_name":"Schölkopf","full_name":"Schölkopf, Bernhard"},{"first_name":"Olivier","last_name":"Bachem","full_name":"Bachem, Olivier"}],"publisher":"Association for the Advancement of Artificial Intelligence","external_id":{"arxiv":["2007.14184"]},"month":"07","publication_status":"published","page":"13681-13684","issue":"9","_id":"14186","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2007.14184"}],"arxiv":1,"abstract":[{"lang":"eng","text":"The goal of the unsupervised learning of disentangled representations is to\r\nseparate the independent explanatory factors of variation in the data without\r\naccess to supervision. In this paper, we summarize the results of Locatello et\r\nal., 2019, and focus on their implications for practitioners. We discuss the\r\ntheoretical result showing that the unsupervised learning of disentangled\r\nrepresentations is fundamentally impossible without inductive biases and the\r\npractical challenges it entails. Finally, we comment on our experimental\r\nfindings, highlighting the limitations of state-of-the-art approaches and\r\ndirections for future research."}],"doi":"10.1609/aaai.v34i09.7120","scopus_import":"1","volume":34,"title":"A commentary on the unsupervised learning of disentangled representations","publication":"The 34th AAAI Conference on Artificial Intelligence","extern":"1","oa":1,"oa_version":"Preprint","year":"2020"},{"quality_controlled":"1","date_published":"2020-07-27T00:00:00Z","date_updated":"2023-09-12T08:03:40Z","conference":{"end_date":"2020-07-18","start_date":"2020-07-13","name":"International Conference on Machine Learning","location":"Virtual"},"citation":{"ama":"Négiar G, Dresdner G, Tsai A, et al. Stochastic Frank-Wolfe for constrained finite-sum minimization. In: <i>Proceedings of the 37th International Conference on Machine Learning</i>. Vol 119. ; 2020:7253-7262.","ieee":"G. Négiar <i>et al.</i>, “Stochastic Frank-Wolfe for constrained finite-sum minimization,” in <i>Proceedings of the 37th International Conference on Machine Learning</i>, Virtual, 2020, vol. 119, pp. 7253–7262.","ista":"Négiar G, Dresdner G, Tsai A, Ghaoui LE, Locatello F, Freund RM, Pedregosa F. 2020. Stochastic Frank-Wolfe for constrained finite-sum minimization. Proceedings of the 37th International Conference on Machine Learning. International Conference on Machine Learning, PMLR, vol. 119, 7253–7262.","chicago":"Négiar, Geoffrey, Gideon Dresdner, Alicia Tsai, Laurent El Ghaoui, Francesco Locatello, Robert M. Freund, and Fabian Pedregosa. “Stochastic Frank-Wolfe for Constrained Finite-Sum Minimization.” In <i>Proceedings of the 37th International Conference on Machine Learning</i>, 119:7253–62, 2020.","apa":"Négiar, G., Dresdner, G., Tsai, A., Ghaoui, L. E., Locatello, F., Freund, R. M., &#38; Pedregosa, F. (2020). Stochastic Frank-Wolfe for constrained finite-sum minimization. In <i>Proceedings of the 37th International Conference on Machine Learning</i> (Vol. 119, pp. 7253–7262). Virtual.","mla":"Négiar, Geoffrey, et al. “Stochastic Frank-Wolfe for Constrained Finite-Sum Minimization.” <i>Proceedings of the 37th International Conference on Machine Learning</i>, vol. 119, 2020, pp. 7253–62.","short":"G. Négiar, G. Dresdner, A. Tsai, L.E. Ghaoui, F. Locatello, R.M. Freund, F. Pedregosa, in:, Proceedings of the 37th International Conference on Machine Learning, 2020, pp. 7253–7262."},"intvolume":"       119","type":"conference","language":[{"iso":"eng"}],"external_id":{"arxiv":["2002.11860"]},"author":[{"first_name":"Geoffrey","last_name":"Négiar","full_name":"Négiar, Geoffrey"},{"first_name":"Gideon","last_name":"Dresdner","full_name":"Dresdner, Gideon"},{"full_name":"Tsai, Alicia","first_name":"Alicia","last_name":"Tsai"},{"last_name":"Ghaoui","first_name":"Laurent El","full_name":"Ghaoui, Laurent El"},{"id":"26cfd52f-2483-11ee-8040-88983bcc06d4","last_name":"Locatello","first_name":"Francesco","full_name":"Locatello, Francesco","orcid":"0000-0002-4850-0683"},{"first_name":"Robert M.","last_name":"Freund","full_name":"Freund, Robert M."},{"first_name":"Fabian","last_name":"Pedregosa","full_name":"Pedregosa, Fabian"}],"date_created":"2023-08-22T14:07:52Z","department":[{"_id":"FrLo"}],"day":"27","status":"public","article_processing_charge":"No","_id":"14187","publication_status":"published","page":"7253-7262","arxiv":1,"abstract":[{"lang":"eng","text":"We propose a novel Stochastic Frank-Wolfe (a.k.a. conditional gradient)\r\nalgorithm for constrained smooth finite-sum minimization with a generalized\r\nlinear prediction/structure. This class of problems includes empirical risk\r\nminimization with sparse, low-rank, or other structured constraints. The\r\nproposed method is simple to implement, does not require step-size tuning, and\r\nhas a constant per-iteration cost that is independent of the dataset size.\r\nFurthermore, as a byproduct of the method we obtain a stochastic estimator of\r\nthe Frank-Wolfe gap that can be used as a stopping criterion. Depending on the\r\nsetting, the proposed method matches or improves on the best computational\r\nguarantees for Stochastic Frank-Wolfe algorithms. Benchmarks on several\r\ndatasets highlight different regimes in which the proposed method exhibits a\r\nfaster empirical convergence than related methods. Finally, we provide an\r\nimplementation of all considered methods in an open-source package."}],"main_file_link":[{"url":"https://arxiv.org/abs/2002.11860","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"07","alternative_title":["PMLR"],"oa_version":"Preprint","oa":1,"year":"2020","title":"Stochastic Frank-Wolfe for constrained finite-sum minimization","volume":119,"extern":"1","publication":"Proceedings of the 37th International Conference on Machine Learning"},{"oa_version":"Preprint","oa":1,"year":"2020","title":"Weakly-supervised disentanglement without compromises","volume":119,"extern":"1","publication":"Proceedings of the 37th International Conference on Machine Learning","page":"6348–6359","publication_status":"published","_id":"14188","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2002.02886"}],"abstract":[{"lang":"eng","text":"Intelligent agents should be able to learn useful representations by\r\nobserving changes in their environment. We model such observations as pairs of\r\nnon-i.i.d. images sharing at least one of the underlying factors of variation.\r\nFirst, we theoretically show that only knowing how many factors have changed,\r\nbut not which ones, is sufficient to learn disentangled representations.\r\nSecond, we provide practical algorithms that learn disentangled representations\r\nfrom pairs of images without requiring annotation of groups, individual\r\nfactors, or the number of factors that have changed. Third, we perform a\r\nlarge-scale empirical study and show that such pairs of observations are\r\nsufficient to reliably learn disentangled representations on several benchmark\r\ndata sets. Finally, we evaluate our learned representations and find that they\r\nare simultaneously useful on a diverse suite of tasks, including generalization\r\nunder covariate shifts, fairness, and abstract reasoning. Overall, our results\r\ndemonstrate that weak supervision enables learning of useful disentangled\r\nrepresentations in realistic scenarios."}],"arxiv":1,"month":"07","alternative_title":["PMLR"],"external_id":{"arxiv":["2002.02886"]},"author":[{"first_name":"Francesco","last_name":"Locatello","id":"26cfd52f-2483-11ee-8040-88983bcc06d4","full_name":"Locatello, Francesco","orcid":"0000-0002-4850-0683"},{"last_name":"Poole","first_name":"Ben","full_name":"Poole, Ben"},{"first_name":"Gunnar","last_name":"Rätsch","full_name":"Rätsch, Gunnar"},{"last_name":"Schölkopf","first_name":"Bernhard","full_name":"Schölkopf, Bernhard"},{"last_name":"Bachem","first_name":"Olivier","full_name":"Bachem, Olivier"},{"first_name":"Michael","last_name":"Tschannen","full_name":"Tschannen, Michael"}],"department":[{"_id":"FrLo"}],"date_created":"2023-08-22T14:08:14Z","day":"07","status":"public","article_processing_charge":"No","quality_controlled":"1","date_published":"2020-07-07T00:00:00Z","citation":{"apa":"Locatello, F., Poole, B., Rätsch, G., Schölkopf, B., Bachem, O., &#38; Tschannen, M. (2020). Weakly-supervised disentanglement without compromises. In <i>Proceedings of the 37th International Conference on Machine Learning</i> (Vol. 119, pp. 6348–6359). Virtual.","chicago":"Locatello, Francesco, Ben Poole, Gunnar Rätsch, Bernhard Schölkopf, Olivier Bachem, and Michael Tschannen. “Weakly-Supervised Disentanglement without Compromises.” In <i>Proceedings of the 37th International Conference on Machine Learning</i>, 119:6348–6359, 2020.","short":"F. Locatello, B. Poole, G. Rätsch, B. Schölkopf, O. Bachem, M. Tschannen, in:, Proceedings of the 37th International Conference on Machine Learning, 2020, pp. 6348–6359.","mla":"Locatello, Francesco, et al. “Weakly-Supervised Disentanglement without Compromises.” <i>Proceedings of the 37th International Conference on Machine Learning</i>, vol. 119, 2020, pp. 6348–6359.","ama":"Locatello F, Poole B, Rätsch G, Schölkopf B, Bachem O, Tschannen M. Weakly-supervised disentanglement without compromises. In: <i>Proceedings of the 37th International Conference on Machine Learning</i>. Vol 119. ; 2020:6348–6359.","ieee":"F. Locatello, B. Poole, G. Rätsch, B. Schölkopf, O. Bachem, and M. Tschannen, “Weakly-supervised disentanglement without compromises,” in <i>Proceedings of the 37th International Conference on Machine Learning</i>, Virtual, 2020, vol. 119, pp. 6348–6359.","ista":"Locatello F, Poole B, Rätsch G, Schölkopf B, Bachem O, Tschannen M. 2020. Weakly-supervised disentanglement without compromises. Proceedings of the 37th International Conference on Machine Learning. International Conference on Machine Learning, PMLR, vol. 119, 6348–6359."},"date_updated":"2024-10-14T12:28:02Z","conference":{"end_date":"2020-07-18","start_date":"2020-07-13","name":"International Conference on Machine Learning","location":"Virtual"},"intvolume":"       119","type":"conference","language":[{"iso":"eng"}]},{"intvolume":"        21","language":[{"iso":"eng"}],"type":"journal_article","date_published":"2020-09-01T00:00:00Z","quality_controlled":"1","citation":{"ama":"Locatello F, Bauer S, Lucic M, et al. A sober look at the unsupervised learning of disentangled representations and their evaluation. <i>Journal of Machine Learning Research</i>. 2020;21.","ieee":"F. Locatello <i>et al.</i>, “A sober look at the unsupervised learning of disentangled representations and their evaluation,” <i>Journal of Machine Learning Research</i>, vol. 21. MIT Press, 2020.","ista":"Locatello F, Bauer S, Lucic M, Rätsch G, Gelly S, Schölkopf B, Bachem O. 2020. A sober look at the unsupervised learning of disentangled representations and their evaluation. Journal of Machine Learning Research. 21, 209.","chicago":"Locatello, Francesco, Stefan Bauer, Mario Lucic, Gunnar Rätsch, Sylvain Gelly, Bernhard Schölkopf, and Olivier Bachem. “A Sober Look at the Unsupervised Learning of Disentangled Representations and Their Evaluation.” <i>Journal of Machine Learning Research</i>. MIT Press, 2020.","apa":"Locatello, F., Bauer, S., Lucic, M., Rätsch, G., Gelly, S., Schölkopf, B., &#38; Bachem, O. (2020). A sober look at the unsupervised learning of disentangled representations and their evaluation. <i>Journal of Machine Learning Research</i>. MIT Press.","short":"F. Locatello, S. Bauer, M. Lucic, G. Rätsch, S. Gelly, B. Schölkopf, O. Bachem, Journal of Machine Learning Research 21 (2020).","mla":"Locatello, Francesco, et al. “A Sober Look at the Unsupervised Learning of Disentangled Representations and Their Evaluation.” <i>Journal of Machine Learning Research</i>, vol. 21, 209, MIT Press, 2020."},"date_updated":"2024-10-14T12:28:26Z","department":[{"_id":"FrLo"}],"date_created":"2023-08-22T14:10:34Z","status":"public","article_processing_charge":"No","article_number":"209","day":"01","author":[{"first_name":"Francesco","last_name":"Locatello","id":"26cfd52f-2483-11ee-8040-88983bcc06d4","orcid":"0000-0002-4850-0683","full_name":"Locatello, Francesco"},{"first_name":"Stefan","last_name":"Bauer","full_name":"Bauer, Stefan"},{"full_name":"Lucic, Mario","first_name":"Mario","last_name":"Lucic"},{"last_name":"Rätsch","first_name":"Gunnar","full_name":"Rätsch, Gunnar"},{"full_name":"Gelly, Sylvain","last_name":"Gelly","first_name":"Sylvain"},{"first_name":"Bernhard","last_name":"Schölkopf","full_name":"Schölkopf, Bernhard"},{"full_name":"Bachem, Olivier","last_name":"Bachem","first_name":"Olivier"}],"publisher":"MIT Press","article_type":"original","external_id":{"arxiv":["2010.14766"]},"month":"09","publication_status":"published","license":"https://creativecommons.org/licenses/by/4.0/","_id":"14195","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://jmlr.csail.mit.edu/papers/v21/19-976.html","open_access":"1"}],"arxiv":1,"abstract":[{"lang":"eng","text":"The idea behind the unsupervised learning of disentangled representations is that real-world data is generated by a few explanatory factors of variation which can be recovered by unsupervised learning algorithms. In this paper, we provide a sober look at recent progress in the field and challenge some common assumptions. We first theoretically show that the unsupervised learning of disentangled representations is fundamentally impossible without inductive biases on both the models and the data. Then, we train over 14000\r\n models covering most prominent methods and evaluation metrics in a reproducible large-scale experimental study on eight data sets. We observe that while the different methods successfully enforce properties “encouraged” by the corresponding losses, well-disentangled models seemingly cannot be identified without supervision. Furthermore, different evaluation metrics do not always agree on what should be considered “disentangled” and exhibit systematic differences in the estimation. Finally, increased disentanglement does not seem to necessarily lead to a decreased sample complexity of learning for downstream tasks. Our results suggest that future work on disentanglement learning should be explicit about the role of inductive biases and (implicit) supervision, investigate concrete benefits of enforcing disentanglement of the learned representations, and consider a reproducible experimental setup covering several data sets."}],"scopus_import":"1","title":"A sober look at the unsupervised learning of disentangled representations and their evaluation","volume":21,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication":"Journal of Machine Learning Research","extern":"1","oa_version":"Published Version","oa":1,"has_accepted_license":"1","year":"2020","ddc":["000"]},{"conference":{"location":"Virtual","name":"NeurIPS: Neural Information Processing Systems","start_date":"2020-12-06","end_date":"2020-12-12"},"date_updated":"2025-07-10T11:50:47Z","citation":{"ista":"Locatello F, Weissenborn D, Unterthiner T, Mahendran A, Heigold G, Uszkoreit J, Dosovitskiy A, Kipf T. 2020. Object-centric learning with slot attention. 34th International Conference on Neural Information Processing Systems. NeurIPS: Neural Information Processing Systems, Advances in Neural Information Processing Systems, vol. 33, 11525–11538.","ieee":"F. Locatello <i>et al.</i>, “Object-centric learning with slot attention,” in <i>34th International Conference on Neural Information Processing Systems</i>, Virtual, 2020, vol. 33, pp. 11525–11538.","ama":"Locatello F, Weissenborn D, Unterthiner T, et al. Object-centric learning with slot attention. In: <i>34th International Conference on Neural Information Processing Systems</i>. Vol 33. Neural Information Processing Systems Foundation; 2020:11525-11538.","mla":"Locatello, Francesco, et al. “Object-Centric Learning with Slot Attention.” <i>34th International Conference on Neural Information Processing Systems</i>, vol. 33, Neural Information Processing Systems Foundation, 2020, pp. 11525–38.","short":"F. Locatello, D. Weissenborn, T. Unterthiner, A. Mahendran, G. Heigold, J. Uszkoreit, A. Dosovitskiy, T. Kipf, in:, 34th International Conference on Neural Information Processing Systems, Neural Information Processing Systems Foundation, 2020, pp. 11525–11538.","apa":"Locatello, F., Weissenborn, D., Unterthiner, T., Mahendran, A., Heigold, G., Uszkoreit, J., … Kipf, T. (2020). Object-centric learning with slot attention. In <i>34th International Conference on Neural Information Processing Systems</i> (Vol. 33, pp. 11525–11538). Virtual: Neural Information Processing Systems Foundation.","chicago":"Locatello, Francesco, Dirk Weissenborn, Thomas Unterthiner, Aravindh Mahendran, Georg Heigold, Jakob Uszkoreit, Alexey Dosovitskiy, and Thomas Kipf. “Object-Centric Learning with Slot Attention.” In <i>34th International Conference on Neural Information Processing Systems</i>, 33:11525–38. Neural Information Processing Systems Foundation, 2020."},"date_published":"2020-12-20T00:00:00Z","quality_controlled":"1","language":[{"iso":"eng"}],"type":"conference","intvolume":"        33","author":[{"orcid":"0000-0002-4850-0683","full_name":"Locatello, Francesco","last_name":"Locatello","id":"26cfd52f-2483-11ee-8040-88983bcc06d4","first_name":"Francesco"},{"full_name":"Weissenborn, Dirk","last_name":"Weissenborn","first_name":"Dirk"},{"first_name":"Thomas","last_name":"Unterthiner","full_name":"Unterthiner, Thomas"},{"full_name":"Mahendran, Aravindh","first_name":"Aravindh","last_name":"Mahendran"},{"full_name":"Heigold, Georg","first_name":"Georg","last_name":"Heigold"},{"last_name":"Uszkoreit","first_name":"Jakob","full_name":"Uszkoreit, Jakob"},{"first_name":"Alexey","last_name":"Dosovitskiy","full_name":"Dosovitskiy, Alexey"},{"full_name":"Kipf, Thomas","first_name":"Thomas","last_name":"Kipf"}],"external_id":{"arxiv":["2006.15055"]},"publisher":"Neural Information Processing Systems Foundation","status":"public","publication_identifier":{"isbn":["9781713829546"],"eissn":["1049-5258"]},"article_processing_charge":"No","day":"20","date_created":"2023-09-13T12:03:46Z","department":[{"_id":"FrLo"}],"abstract":[{"lang":"eng","text":"Learning object-centric representations of complex scenes is a promising step towards enabling efficient abstract reasoning from low-level perceptual features. Yet, most deep learning approaches learn distributed representations that do not capture the compositional properties of natural scenes. In this paper, we present the Slot Attention module, an architectural component that interfaces with perceptual representations such as the output of a convolutional neural network and produces a set of task-dependent abstract representations which we call slots. These slots are exchangeable and can bind to any object in the input by specializing through a competitive procedure over multiple rounds of attention. We empirically demonstrate that Slot Attention can extract object-centric representations that enable generalization to unseen compositions when trained on unsupervised object discovery and supervised property prediction tasks.\r\n\r\n"}],"arxiv":1,"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2006.15055","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"14326","page":"11525-11538","publication_status":"published","alternative_title":["Advances in Neural Information Processing Systems"],"month":"12","year":"2020","oa_version":"Preprint","oa":1,"publication":"34th International Conference on Neural Information Processing Systems","extern":"1","volume":33,"title":"Object-centric learning with slot attention"},{"publisher":"Institute of Science and Technology Austria","file":[{"date_updated":"2023-11-22T14:58:44Z","relation":"main_file","file_id":"14593","content_type":"application/zip","success":1,"creator":"fschur","file_size":49297,"access_level":"open_access","date_created":"2023-11-22T14:58:44Z","checksum":"0108616e2a59e51879ea51299a29b091","file_name":"3Dprint-files_download_v2.zip"},{"checksum":"4c66ddedee4d01c1c4a7978208350cfc","file_name":"readme.txt","date_created":"2023-12-01T10:39:59Z","access_level":"open_access","file_size":641,"content_type":"text/plain","creator":"cchlebak","success":1,"file_id":"14637","relation":"main_file","date_updated":"2023-12-01T10:39:59Z"}],"oa":1,"author":[{"first_name":"Florian KM","last_name":"Schur","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4790-8078","full_name":"Schur, Florian KM"}],"oa_version":"Published Version","year":"2020","ddc":["570"],"has_accepted_license":"1","title":"STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy","department":[{"_id":"FlSc"}],"date_created":"2023-11-22T15:00:57Z","corr_author":"1","related_material":{"record":[{"status":"public","relation":"research_data","id":"8586"}]},"day":"01","tmp":{"image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"article_processing_charge":"No","status":"public","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","file_date_updated":"2023-12-01T10:39:59Z","_id":"14592","date_published":"2020-12-01T00:00:00Z","citation":{"ama":"Schur FK. STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14592\">10.15479/AT:ISTA:14592</a>","ista":"Schur FK. 2020. STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:14592\">10.15479/AT:ISTA:14592</a>.","ieee":"F. K. Schur, “STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy.” Institute of Science and Technology Austria, 2020.","apa":"Schur, F. K. (2020). STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:14592\">https://doi.org/10.15479/AT:ISTA:14592</a>","chicago":"Schur, Florian KM. “STL-Files for 3D-Printed Grid Holders Described in  Fäßler F, Zens B, et Al.; 3D Printed Cell Culture Grid Holders for Improved Cellular Specimen Preparation in Cryo-Electron Microscopy.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:14592\">https://doi.org/10.15479/AT:ISTA:14592</a>.","short":"F.K. Schur, (2020).","mla":"Schur, Florian KM. <i>STL-Files for 3D-Printed Grid Holders Described in  Fäßler F, Zens B, et Al.; 3D Printed Cell Culture Grid Holders for Improved Cellular Specimen Preparation in Cryo-Electron Microscopy</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14592\">10.15479/AT:ISTA:14592</a>."},"doi":"10.15479/AT:ISTA:14592","contributor":[{"first_name":"Florian","contributor_type":"researcher","id":"404F5528-F248-11E8-B48F-1D18A9856A87","last_name":"Fäßler","orcid":"0000-0001-7149-769X"},{"id":"45FD126C-F248-11E8-B48F-1D18A9856A87","last_name":"Zens","contributor_type":"researcher","first_name":"Bettina"},{"last_name":"Hauschild","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","contributor_type":"researcher"},{"id":"48AD8942-F248-11E8-B48F-1D18A9856A87","last_name":"Schur","contributor_type":"researcher","first_name":"Florian KM","orcid":"0000-0003-4790-8078"}],"date_updated":"2025-06-12T07:35:28Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Cryo-electron microscopy (cryo-EM) of cellular specimens provides insights into biological processes and structures within a native context. However, a major challenge still lies in the efficient and reproducible preparation of adherent cells for subsequent cryo-EM analysis. This is due to the sensitivity of many cellular specimens to the varying seeding and culturing conditions required for EM experiments, the often limited amount of cellular material and also the fragility of EM grids and their substrate. Here, we present low-cost and reusable 3D printed grid holders, designed to improve specimen preparation when culturing challenging cellular samples directly on grids. The described grid holders increase cell culture reproducibility and throughput, and reduce the resources required for cell culturing. We show that grid holders can be integrated into various cryo-EM workflows, including micro-patterning approaches to control cell seeding on grids, and for generating samples for cryo-focused ion beam milling and cryo-electron tomography experiments. Their adaptable design allows for the generation of specialized grid holders customized to a large variety of applications."}],"month":"12","type":"research_data","project":[{"_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","grant_number":"P33367","name":"Structure and isoform diversity of the Arp2/3 complex"}]},{"month":"09","_id":"14694","publication_status":"published","page":"1421-1539","abstract":[{"lang":"eng","text":"We study the unique solution m of the Dyson equation \\( -m(z)^{-1} = z\\1 - a + S[m(z)] \\) on a von Neumann algebra A with the constraint Imm≥0. Here, z lies in the complex upper half-plane, a is a self-adjoint element of A and S is a positivity-preserving linear operator on A. We show that m is the Stieltjes transform of a compactly supported A-valued measure on R. Under suitable assumptions, we establish that this measure has a uniformly 1/3-Hölder continuous density with respect to the Lebesgue measure, which is supported on finitely many intervals, called bands. In fact, the density is analytic inside the bands with a square-root growth at the edges and internal cubic root cusps whenever the gap between two bands vanishes. The shape of these singularities is universal and no other singularity may occur. We give a precise asymptotic description of m near the singular points. These asymptotics generalize the analysis at the regular edges given in the companion paper on the Tracy-Widom universality for the edge eigenvalue statistics for correlated random matrices [the first author et al., Ann. Probab. 48, No. 2, 963--1001 (2020; Zbl 1434.60017)] and they play a key role in the proof of the Pearcey universality at the cusp for Wigner-type matrices [G. Cipolloni et al., Pure Appl. Anal. 1, No. 4, 615--707 (2019; Zbl 07142203); the second author et al., Commun. Math. Phys. 378, No. 2, 1203--1278 (2020; Zbl 07236118)]. We also extend the finite dimensional band mass formula from [the first author et al., loc. cit.] to the von Neumann algebra setting by showing that the spectral mass of the bands is topologically rigid under deformations and we conclude that these masses are quantized in some important cases."}],"arxiv":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","keyword":["General Mathematics"],"doi":"10.4171/dm/780","title":"The Dyson equation with linear self-energy: Spectral bands, edges and cusps","volume":25,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication":"Documenta Mathematica","oa_version":"Published Version","oa":1,"file":[{"date_created":"2023-12-18T10:42:32Z","checksum":"12aacc1d63b852ff9a51c1f6b218d4a6","file_name":"2020_DocumentaMathematica_Alt.pdf","file_size":1374708,"access_level":"open_access","file_id":"14695","content_type":"application/pdf","success":1,"creator":"dernst","date_updated":"2023-12-18T10:42:32Z","relation":"main_file"}],"has_accepted_license":"1","ddc":["510"],"year":"2020","intvolume":"        25","language":[{"iso":"eng"}],"type":"journal_article","date_published":"2020-09-01T00:00:00Z","quality_controlled":"1","file_date_updated":"2023-12-18T10:42:32Z","date_updated":"2025-04-15T08:05:00Z","citation":{"ieee":"J. Alt, L. Erdös, and T. H. Krüger, “The Dyson equation with linear self-energy: Spectral bands, edges and cusps,” <i>Documenta Mathematica</i>, vol. 25. EMS Press, pp. 1421–1539, 2020.","ista":"Alt J, Erdös L, Krüger TH. 2020. The Dyson equation with linear self-energy: Spectral bands, edges and cusps. Documenta Mathematica. 25, 1421–1539.","ama":"Alt J, Erdös L, Krüger TH. The Dyson equation with linear self-energy: Spectral bands, edges and cusps. <i>Documenta Mathematica</i>. 2020;25:1421-1539. doi:<a href=\"https://doi.org/10.4171/dm/780\">10.4171/dm/780</a>","short":"J. Alt, L. Erdös, T.H. Krüger, Documenta Mathematica 25 (2020) 1421–1539.","mla":"Alt, Johannes, et al. “The Dyson Equation with Linear Self-Energy: Spectral Bands, Edges and Cusps.” <i>Documenta Mathematica</i>, vol. 25, EMS Press, 2020, pp. 1421–539, doi:<a href=\"https://doi.org/10.4171/dm/780\">10.4171/dm/780</a>.","chicago":"Alt, Johannes, László Erdös, and Torben H Krüger. “The Dyson Equation with Linear Self-Energy: Spectral Bands, Edges and Cusps.” <i>Documenta Mathematica</i>. EMS Press, 2020. <a href=\"https://doi.org/10.4171/dm/780\">https://doi.org/10.4171/dm/780</a>.","apa":"Alt, J., Erdös, L., &#38; Krüger, T. H. (2020). The Dyson equation with linear self-energy: Spectral bands, edges and cusps. <i>Documenta Mathematica</i>. EMS Press. <a href=\"https://doi.org/10.4171/dm/780\">https://doi.org/10.4171/dm/780</a>"},"corr_author":"1","date_created":"2023-12-18T10:37:43Z","department":[{"_id":"LaEr"}],"status":"public","publication_identifier":{"eissn":["1431-0643"],"issn":["1431-0635"]},"article_processing_charge":"Yes","day":"01","related_material":{"record":[{"id":"6183","relation":"earlier_version","status":"public"}]},"author":[{"full_name":"Alt, Johannes","first_name":"Johannes","id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87","last_name":"Alt"},{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","first_name":"László","orcid":"0000-0001-5366-9603","full_name":"Erdös, László"},{"full_name":"Krüger, Torben H","orcid":"0000-0002-4821-3297","first_name":"Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87","last_name":"Krüger"}],"external_id":{"arxiv":["1804.07752"]},"article_type":"original","publisher":"EMS Press"},{"author":[{"last_name":"Rosa","first_name":"Higor Vinícius Dias","full_name":"Rosa, Higor Vinícius Dias"},{"full_name":"Leonardo, Diego Antonio","last_name":"Leonardo","first_name":"Diego Antonio"},{"id":"D96FFDA0-A884-11E9-9968-DC26E6697425","last_name":"Brognara","first_name":"Gabriel","full_name":"Brognara, Gabriel"},{"last_name":"Brandão-Neto","first_name":"José","full_name":"Brandão-Neto, José"},{"full_name":"D'Muniz Pereira, Humberto","last_name":"D'Muniz Pereira","first_name":"Humberto"},{"full_name":"Araújo, Ana Paula Ulian","last_name":"Araújo","first_name":"Ana Paula Ulian"},{"first_name":"Richard Charles","last_name":"Garratt","full_name":"Garratt, Richard Charles"}],"article_type":"original","publisher":"Elsevier","external_id":{"pmid":["32910969"]},"status":"public","article_processing_charge":"No","publication_identifier":{"issn":["0022-2836"]},"day":"02","department":[{"_id":"MaLo"}],"date_created":"2024-02-28T08:50:34Z","citation":{"mla":"Rosa, Higor Vinícius Dias, et al. “Molecular Recognition at Septin Interfaces: The Switches Hold the Key.” <i>Journal of Molecular Biology</i>, vol. 432, no. 21, Elsevier, 2020, pp. 5784–801, doi:<a href=\"https://doi.org/10.1016/j.jmb.2020.09.001\">10.1016/j.jmb.2020.09.001</a>.","short":"H.V.D. Rosa, D.A. Leonardo, G. Brognara, J. Brandão-Neto, H. D’Muniz Pereira, A.P.U. Araújo, R.C. Garratt, Journal of Molecular Biology 432 (2020) 5784–5801.","chicago":"Rosa, Higor Vinícius Dias, Diego Antonio Leonardo, Gabriel Brognara, José Brandão-Neto, Humberto D’Muniz Pereira, Ana Paula Ulian Araújo, and Richard Charles Garratt. “Molecular Recognition at Septin Interfaces: The Switches Hold the Key.” <i>Journal of Molecular Biology</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.jmb.2020.09.001\">https://doi.org/10.1016/j.jmb.2020.09.001</a>.","apa":"Rosa, H. V. D., Leonardo, D. A., Brognara, G., Brandão-Neto, J., D’Muniz Pereira, H., Araújo, A. P. U., &#38; Garratt, R. C. (2020). Molecular recognition at septin interfaces: The switches hold the key. <i>Journal of Molecular Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jmb.2020.09.001\">https://doi.org/10.1016/j.jmb.2020.09.001</a>","ista":"Rosa HVD, Leonardo DA, Brognara G, Brandão-Neto J, D’Muniz Pereira H, Araújo APU, Garratt RC. 2020. Molecular recognition at septin interfaces: The switches hold the key. Journal of Molecular Biology. 432(21), 5784–5801.","ama":"Rosa HVD, Leonardo DA, Brognara G, et al. Molecular recognition at septin interfaces: The switches hold the key. <i>Journal of Molecular Biology</i>. 2020;432(21):5784-5801. doi:<a href=\"https://doi.org/10.1016/j.jmb.2020.09.001\">10.1016/j.jmb.2020.09.001</a>","ieee":"H. V. D. Rosa <i>et al.</i>, “Molecular recognition at septin interfaces: The switches hold the key,” <i>Journal of Molecular Biology</i>, vol. 432, no. 21. Elsevier, pp. 5784–5801, 2020."},"date_updated":"2026-06-18T17:44:49Z","date_published":"2020-10-02T00:00:00Z","quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","intvolume":"       432","year":"2020","ddc":["570"],"oa_version":"Published Version","oa":1,"publication":"Journal of Molecular Biology","title":"Molecular recognition at septin interfaces: The switches hold the key","volume":432,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.jmb.2020.09.001"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"The assembly of a septin filament requires that homologous monomers must distinguish between one another in establishing appropriate interfaces with their neighbors. To understand this phenomenon at the molecular level, we present the first four crystal structures of heterodimeric septin complexes. We describe in detail the two distinct types of G-interface present within the octameric particles, which must polymerize to form filaments. These are formed between SEPT2 and SEPT6 and between SEPT7 and SEPT3, and their description permits an understanding of the structural basis for the selectivity necessary for correct filament assembly. By replacing SEPT6 by SEPT8 or SEPT11, it is possible to rationalize Kinoshita's postulate, which predicts the exchangeability of septins from within a subgroup. Switches I and II, which in classical small GTPases provide a mechanism for nucleotide-dependent conformational change, have been repurposed in septins to play a fundamental role in molecular recognition. Specifically, it is switch I which holds the key to discriminating between the two different G-interfaces. Moreover, residues which are characteristic for a given subgroup play subtle, but pivotal, roles in guaranteeing that the correct interfaces are formed.","lang":"eng"}],"doi":"10.1016/j.jmb.2020.09.001","keyword":["Molecular Biology","Structural Biology"],"page":"5784-5801","publication_status":"published","pmid":1,"issue":"21","_id":"15036","month":"10"},{"file":[{"date_created":"2024-02-28T12:39:56Z","checksum":"c538a5008f7827f62d17d40a3bfabe65","file_name":"2020_MolecularPlant_MoulinierAnzola.pdf","file_size":3089212,"access_level":"open_access","file_id":"15038","creator":"dernst","success":1,"content_type":"application/pdf","date_updated":"2024-02-28T12:39:56Z","relation":"main_file"}],"oa_version":"Published Version","oa":1,"ddc":["580"],"year":"2020","has_accepted_license":"1","title":"TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants","volume":13,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication":"Molecular Plant","publication_status":"published","page":"717-731","pmid":1,"_id":"15037","issue":"5","doi":"10.1016/j.molp.2020.02.012","keyword":["Plant Science","Molecular Biology"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Protein abundance and localization at the plasma membrane (PM) shapes plant development and mediates adaptation to changing environmental conditions. It is regulated by ubiquitination, a post-translational modification crucial for the proper sorting of endocytosed PM proteins to the vacuole for subsequent degradation. To understand the significance and the variety of roles played by this reversible modification, the function of ubiquitin receptors, which translate the ubiquitin signature into a cellular response, needs to be elucidated. In this study, we show that TOL (TOM1-like) proteins function in plants as multivalent ubiquitin receptors, governing ubiquitinated cargo delivery to the vacuole via the conserved Endosomal Sorting Complex Required for Transport (ESCRT) pathway. TOL2 and TOL6 interact with components of the ESCRT machinery and bind to K63-linked ubiquitin via two tandemly arranged conserved ubiquitin-binding domains. Mutation of these domains results not only in a loss of ubiquitin binding but also altered localization, abolishing TOL6 ubiquitin receptor activity. Function and localization of TOL6 is itself regulated by ubiquitination, whereby TOL6 ubiquitination potentially modulates degradation of PM-localized cargoes, assisting in the fine-tuning of the delicate interplay between protein recycling and downregulation. Taken together, our findings demonstrate the function and regulation of a ubiquitin receptor that mediates vacuolar degradation of PM proteins in higher plants.","lang":"eng"}],"month":"05","publisher":"Elsevier","article_type":"original","external_id":{"pmid":["32087370"]},"author":[{"last_name":"Moulinier-Anzola","first_name":"Jeanette","full_name":"Moulinier-Anzola, Jeanette"},{"full_name":"Schwihla, Maximilian","first_name":"Maximilian","last_name":"Schwihla"},{"full_name":"De-Araújo, Lucinda","first_name":"Lucinda","last_name":"De-Araújo"},{"full_name":"Artner, Christina","last_name":"Artner","id":"45DF286A-F248-11E8-B48F-1D18A9856A87","first_name":"Christina"},{"full_name":"Jörg, Lisa","first_name":"Lisa","last_name":"Jörg"},{"full_name":"Konstantinova, Nataliia","last_name":"Konstantinova","first_name":"Nataliia"},{"first_name":"Christian","last_name":"Luschnig","full_name":"Luschnig, Christian"},{"full_name":"Korbei, Barbara","last_name":"Korbei","first_name":"Barbara"}],"department":[{"_id":"EvBe"}],"date_created":"2024-02-28T08:55:56Z","day":"04","article_processing_charge":"No","status":"public","publication_identifier":{"issn":["1674-2052"]},"file_date_updated":"2024-02-28T12:39:56Z","quality_controlled":"1","date_published":"2020-05-04T00:00:00Z","citation":{"short":"J. Moulinier-Anzola, M. Schwihla, L. De-Araújo, C. Artner, L. Jörg, N. Konstantinova, C. Luschnig, B. Korbei, Molecular Plant 13 (2020) 717–731.","mla":"Moulinier-Anzola, Jeanette, et al. “TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway in Higher Plants.” <i>Molecular Plant</i>, vol. 13, no. 5, Elsevier, 2020, pp. 717–31, doi:<a href=\"https://doi.org/10.1016/j.molp.2020.02.012\">10.1016/j.molp.2020.02.012</a>.","chicago":"Moulinier-Anzola, Jeanette, Maximilian Schwihla, Lucinda De-Araújo, Christina Artner, Lisa Jörg, Nataliia Konstantinova, Christian Luschnig, and Barbara Korbei. “TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway in Higher Plants.” <i>Molecular Plant</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.molp.2020.02.012\">https://doi.org/10.1016/j.molp.2020.02.012</a>.","apa":"Moulinier-Anzola, J., Schwihla, M., De-Araújo, L., Artner, C., Jörg, L., Konstantinova, N., … Korbei, B. (2020). TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants. <i>Molecular Plant</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.molp.2020.02.012\">https://doi.org/10.1016/j.molp.2020.02.012</a>","ama":"Moulinier-Anzola J, Schwihla M, De-Araújo L, et al. TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants. <i>Molecular Plant</i>. 2020;13(5):717-731. doi:<a href=\"https://doi.org/10.1016/j.molp.2020.02.012\">10.1016/j.molp.2020.02.012</a>","ieee":"J. Moulinier-Anzola <i>et al.</i>, “TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants,” <i>Molecular Plant</i>, vol. 13, no. 5. Elsevier, pp. 717–731, 2020.","ista":"Moulinier-Anzola J, Schwihla M, De-Araújo L, Artner C, Jörg L, Konstantinova N, Luschnig C, Korbei B. 2020. TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants. Molecular Plant. 13(5), 717–731."},"date_updated":"2024-02-28T12:41:52Z","intvolume":"        13","type":"journal_article","language":[{"iso":"eng"}]},{"day":"03","publication_identifier":{"issn":["2374-3468"]},"status":"public","article_processing_charge":"No","department":[{"_id":"KrCh"}],"date_created":"2024-03-04T08:07:22Z","article_type":"original","publisher":"Association for the Advancement of Artificial Intelligence","external_id":{"arxiv":["2002.12086"]},"author":[{"full_name":"Brázdil, Tomáš","last_name":"Brázdil","first_name":"Tomáš"},{"last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu"},{"last_name":"Novotný","first_name":"Petr","full_name":"Novotný, Petr"},{"full_name":"Vahala, Jiří","last_name":"Vahala","first_name":"Jiří"}],"project":[{"call_identifier":"FWF","name":"Game Theory","grant_number":"S11407","_id":"25863FF4-B435-11E9-9278-68D0E5697425"}],"type":"journal_article","language":[{"iso":"eng"}],"intvolume":"        34","citation":{"short":"T. Brázdil, K. Chatterjee, P. Novotný, J. Vahala, Proceedings of the 34th AAAI Conference on Artificial Intelligence 34 (2020) 9794–9801.","mla":"Brázdil, Tomáš, et al. “Reinforcement Learning of Risk-Constrained Policies in Markov Decision Processes.” <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>, vol. 34, no. 06, Association for the Advancement of Artificial Intelligence, 2020, pp. 9794–801, doi:<a href=\"https://doi.org/10.1609/aaai.v34i06.6531\">10.1609/aaai.v34i06.6531</a>.","apa":"Brázdil, T., Chatterjee, K., Novotný, P., &#38; Vahala, J. (2020). Reinforcement learning of risk-constrained policies in Markov decision processes. <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>. New York, NY, United States: Association for the Advancement of Artificial Intelligence. <a href=\"https://doi.org/10.1609/aaai.v34i06.6531\">https://doi.org/10.1609/aaai.v34i06.6531</a>","chicago":"Brázdil, Tomáš, Krishnendu Chatterjee, Petr Novotný, and Jiří Vahala. “Reinforcement Learning of Risk-Constrained Policies in Markov Decision Processes.” <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>. Association for the Advancement of Artificial Intelligence, 2020. <a href=\"https://doi.org/10.1609/aaai.v34i06.6531\">https://doi.org/10.1609/aaai.v34i06.6531</a>.","ama":"Brázdil T, Chatterjee K, Novotný P, Vahala J. Reinforcement learning of risk-constrained policies in Markov decision processes. <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>. 2020;34(06):9794-9801. doi:<a href=\"https://doi.org/10.1609/aaai.v34i06.6531\">10.1609/aaai.v34i06.6531</a>","ieee":"T. Brázdil, K. Chatterjee, P. Novotný, and J. Vahala, “Reinforcement learning of risk-constrained policies in Markov decision processes,” <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>, vol. 34, no. 06. Association for the Advancement of Artificial Intelligence, pp. 9794–9801, 2020.","ista":"Brázdil T, Chatterjee K, Novotný P, Vahala J. 2020. Reinforcement learning of risk-constrained policies in Markov decision processes. Proceedings of the 34th AAAI Conference on Artificial Intelligence. 34(06), 9794–9801."},"conference":{"name":"AAAI: Conference on Artificial Intelligence","location":"New York, NY, United States","end_date":"2020-02-12","start_date":"2020-02-07"},"date_updated":"2025-04-15T06:30:08Z","quality_controlled":"1","date_published":"2020-04-03T00:00:00Z","publication":"Proceedings of the 34th AAAI Conference on Artificial Intelligence","volume":34,"title":"Reinforcement learning of risk-constrained policies in Markov decision processes","year":"2020","oa":1,"oa_version":"Preprint","acknowledgement":"Krishnendu Chatterjee is supported by the Austrian Science Fund (FWF) NFN Grant No. S11407-N23 (RiSE/SHiNE), and COST Action GAMENET. Tomas Brazdil is supported by the Grant Agency of Masaryk University grant no. MUNI/G/0739/2017 and by the Czech Science Foundation grant No. 18-11193S. Petr Novotny and Jirı Vahala are supported by the Czech Science Foundation grant No. GJ19-15134Y.","month":"04","doi":"10.1609/aaai.v34i06.6531","keyword":["General Medicine"],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2002.12086"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"<jats:p>Markov decision processes (MDPs) are the defacto framework for sequential decision making in the presence of stochastic uncertainty. A classical optimization criterion for MDPs is to maximize the expected discounted-sum payoff, which ignores low probability catastrophic events with highly negative impact on the system. On the other hand, risk-averse policies require the probability of undesirable events to be below a given threshold, but they do not account for optimization of the expected payoff. We consider MDPs with discounted-sum payoff with failure states which represent catastrophic outcomes. The objective of risk-constrained planning is to maximize the expected discounted-sum payoff among risk-averse policies that ensure the probability to encounter a failure state is below a desired threshold. Our main contribution is an efficient risk-constrained planning algorithm that combines UCT-like search with a predictor learned through interaction with the MDP (in the style of AlphaZero) and with a risk-constrained action selection via linear programming. We demonstrate the effectiveness of our approach with experiments on classical MDPs from the literature, including benchmarks with an order of 106 states.</jats:p>","lang":"eng"}],"arxiv":1,"publication_status":"published","page":"9794-9801","issue":"06","_id":"15055"},{"type":"journal_article","language":[{"iso":"eng"}],"intvolume":"         6","citation":{"ista":"Park S, Artan M, Han SH, Park H-EH, Jung Y, Hwang AB, Shin WS, Kim K-T, Lee S-JV. 2020. VRK-1 extends life span by activation of AMPK via phosphorylation. Science Advances. 6(27), aaw7824.","ama":"Park S, Artan M, Han SH, et al. VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. 2020;6(27). doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>","ieee":"S. Park <i>et al.</i>, “VRK-1 extends life span by activation of AMPK via phosphorylation,” <i>Science Advances</i>, vol. 6, no. 27. American Association for the Advancement of Science, 2020.","apa":"Park, S., Artan, M., Han, S. H., Park, H.-E. H., Jung, Y., Hwang, A. B., … Lee, S.-J. V. (2020). VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>","chicago":"Park, Sangsoon, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung, Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, and Seung-Jae V. Lee. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>.","mla":"Park, Sangsoon, et al. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>, vol. 6, no. 27, aaw7824, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>.","short":"S. Park, M. Artan, S.H. Han, H.-E.H. Park, Y. Jung, A.B. Hwang, W.S. Shin, K.-T. Kim, S.-J.V. Lee, Science Advances 6 (2020)."},"date_updated":"2024-03-04T09:52:09Z","quality_controlled":"1","file_date_updated":"2024-03-04T09:46:41Z","date_published":"2020-07-01T00:00:00Z","article_number":"aaw7824","day":"01","article_processing_charge":"No","publication_identifier":{"eissn":["2375-2548"]},"status":"public","department":[{"_id":"MaDe"}],"date_created":"2024-03-04T09:41:57Z","publisher":"American Association for the Advancement of Science","article_type":"original","author":[{"full_name":"Park, Sangsoon","first_name":"Sangsoon","last_name":"Park"},{"first_name":"Murat","last_name":"Artan","id":"C407B586-6052-11E9-B3AE-7006E6697425","orcid":"0000-0001-8945-6992","full_name":"Artan, Murat"},{"full_name":"Han, Seung Hyun","last_name":"Han","first_name":"Seung Hyun"},{"full_name":"Park, Hae-Eun H.","last_name":"Park","first_name":"Hae-Eun H."},{"full_name":"Jung, Yoonji","last_name":"Jung","first_name":"Yoonji"},{"full_name":"Hwang, Ara B.","last_name":"Hwang","first_name":"Ara B."},{"full_name":"Shin, Won Sik","last_name":"Shin","first_name":"Won Sik"},{"full_name":"Kim, Kyong-Tai","first_name":"Kyong-Tai","last_name":"Kim"},{"full_name":"Lee, Seung-Jae V.","last_name":"Lee","first_name":"Seung-Jae V."}],"acknowledgement":"This research was supported by grants NRF-2019R1A3B2067745 and NRF-2017R1A5A1015366 funded by the Korean Government (MSIT) through the National Research Foundation (NRF) of Korea to S.-J.V.L. and by grant Basic Science Research Program (No. 2019R1A2C2009440) funded by the Korean Government (MSIT) through the NRF of Korea to K.-T.K. ","month":"07","doi":"10.1126/sciadv.aaw7824","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and germline proliferation. However, the role of VRK-1 in postmitotic cells and adult life span remains unknown. Here, we show that VRK-1 increases organismal longevity by activating the cellular energy sensor, AMP-activated protein kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1 in the soma of adult C. elegans increased life span and, conversely, inhibition of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred by mutations that inhibit C. elegans mitochondrial respiration, which requires AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1, promotes longevity through AMPK activation, and this function appears to be conserved between C. elegans and humans."}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","publication_status":"published","issue":"27","_id":"15057","publication":"Science Advances","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"volume":6,"title":"VRK-1 extends life span by activation of AMPK via phosphorylation","year":"2020","ddc":["570"],"has_accepted_license":"1","file":[{"file_id":"15058","content_type":"application/pdf","creator":"dernst","success":1,"date_updated":"2024-03-04T09:46:41Z","relation":"main_file","date_created":"2024-03-04T09:46:41Z","checksum":"a37157cd0de709dce5fe03f4a31cd0b6","file_name":"2020_ScienceAdvances_Park.pdf","access_level":"open_access","file_size":1864415}],"oa":1,"oa_version":"Published Version"},{"language":[{"iso":"eng"}],"type":"conference","acknowledgement":"This work has been financially supported by Comunidad de Madrid S2018/NMT-4333 ARTINLARA-CM projects, and “FUNDACIÓN SENER” REFTA projects.","month":"07","abstract":[{"lang":"eng","text":"In this paper we present a room temperature radiometer that can eliminate the need of using cryostats in satellite payload reducing its weight and improving reliability. The proposed radiometer is based on an electro-optic upconverter that boosts up microwave photons energy by upconverting them into an optical domain what makes them immune to thermal noise even if operating at room temperature. The converter uses a high-quality factor whispering gallery\r\nmode (WGM) resonator providing naturally narrow bandwidth and therefore might be useful for applications like microwave hyperspectral sensing. The upconversion process is explained by\r\nproviding essential information about photon conversion efficiency and sensitivity. To prove the concept, we describe an experiment which shows state-of-the-art photon conversion efficiency n=10-5 per mW of pump power at the frequency of 80 GHz."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","conference":{"start_date":"2020-03-15","end_date":"2020-03-20","location":"Copenhagen, Denmark","name":"EuCAP: European Conference on Antennas and Propagation"},"date_updated":"2024-03-04T10:02:49Z","doi":"10.23919/eucap48036.2020.9135962","citation":{"ama":"Wasiak M, Botello GS, Abdalmalak KA, et al. Compact millimeter and submillimeter-wave photonic radiometer for cubesats. In: <i>14th European Conference on Antennas and Propagation</i>. IEEE; 2020. doi:<a href=\"https://doi.org/10.23919/eucap48036.2020.9135962\">10.23919/eucap48036.2020.9135962</a>","ista":"Wasiak M, Botello GS, Abdalmalak KA, Sedlmeir F, Rueda Sanchez AR, Segovia-Vargas D, Schwefel HGL, Munoz LEG. 2020. Compact millimeter and submillimeter-wave photonic radiometer for cubesats. 14th European Conference on Antennas and Propagation. EuCAP: European Conference on Antennas and Propagation.","ieee":"M. Wasiak <i>et al.</i>, “Compact millimeter and submillimeter-wave photonic radiometer for cubesats,” in <i>14th European Conference on Antennas and Propagation</i>, Copenhagen, Denmark, 2020.","short":"M. Wasiak, G.S. Botello, K.A. Abdalmalak, F. Sedlmeir, A.R. Rueda Sanchez, D. Segovia-Vargas, H.G.L. Schwefel, L.E.G. Munoz, in:, 14th European Conference on Antennas and Propagation, IEEE, 2020.","mla":"Wasiak, Michal, et al. “Compact Millimeter and Submillimeter-Wave Photonic Radiometer for Cubesats.” <i>14th European Conference on Antennas and Propagation</i>, IEEE, 2020, doi:<a href=\"https://doi.org/10.23919/eucap48036.2020.9135962\">10.23919/eucap48036.2020.9135962</a>.","apa":"Wasiak, M., Botello, G. S., Abdalmalak, K. A., Sedlmeir, F., Rueda Sanchez, A. R., Segovia-Vargas, D., … Munoz, L. E. G. (2020). Compact millimeter and submillimeter-wave photonic radiometer for cubesats. In <i>14th European Conference on Antennas and Propagation</i>. Copenhagen, Denmark: IEEE. <a href=\"https://doi.org/10.23919/eucap48036.2020.9135962\">https://doi.org/10.23919/eucap48036.2020.9135962</a>","chicago":"Wasiak, Michal, Gabriel Santamaria Botello, Kerlos Atia Abdalmalak, Florian Sedlmeir, Alfredo R Rueda Sanchez, Daniel Segovia-Vargas, Harald G. L. Schwefel, and Luis Enrique Garcia Munoz. “Compact Millimeter and Submillimeter-Wave Photonic Radiometer for Cubesats.” In <i>14th European Conference on Antennas and Propagation</i>. IEEE, 2020. <a href=\"https://doi.org/10.23919/eucap48036.2020.9135962\">https://doi.org/10.23919/eucap48036.2020.9135962</a>."},"date_published":"2020-07-08T00:00:00Z","quality_controlled":"1","_id":"15059","publication_status":"published","status":"public","publication":"14th European Conference on Antennas and Propagation","article_processing_charge":"No","publication_identifier":{"eisbn":["9788831299008"]},"day":"08","date_created":"2024-03-04T09:57:48Z","department":[{"_id":"JoFi"}],"title":"Compact millimeter and submillimeter-wave photonic radiometer for cubesats","year":"2020","author":[{"last_name":"Wasiak","first_name":"Michal","full_name":"Wasiak, Michal"},{"full_name":"Botello, Gabriel Santamaria","last_name":"Botello","first_name":"Gabriel Santamaria"},{"full_name":"Abdalmalak, Kerlos Atia","first_name":"Kerlos Atia","last_name":"Abdalmalak"},{"first_name":"Florian","last_name":"Sedlmeir","full_name":"Sedlmeir, Florian"},{"id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","last_name":"Rueda Sanchez","first_name":"Alfredo R","full_name":"Rueda Sanchez, Alfredo R","orcid":"0000-0001-6249-5860"},{"full_name":"Segovia-Vargas, Daniel","last_name":"Segovia-Vargas","first_name":"Daniel"},{"full_name":"Schwefel, Harald G. L.","last_name":"Schwefel","first_name":"Harald G. L."},{"last_name":"Munoz","first_name":"Luis Enrique Garcia","full_name":"Munoz, Luis Enrique Garcia"}],"oa_version":"None","publisher":"IEEE"},{"quality_controlled":"1","date_published":"2020-09-08T00:00:00Z","citation":{"ista":"Pinotsis N, Zielinska K, Babuta M, Arolas JL, Kostan J, Khan MB, Schreiner C, Testa Salmazo AP, Ciccarelli L, Puchinger M, Gkougkoulia EA, Ribeiro E de A, Marlovits TC, Bhattacharya A, Djinovic-Carugo K. 2020. Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin. Proceedings of the National Academy of Sciences of the United States of America. 117(36), 22101–22112.","ama":"Pinotsis N, Zielinska K, Babuta M, et al. Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2020;117(36):22101-22112. doi:<a href=\"https://doi.org/10.1073/pnas.1917269117\">10.1073/pnas.1917269117</a>","ieee":"N. Pinotsis <i>et al.</i>, “Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 117, no. 36. National Academy of Sciences, pp. 22101–22112, 2020.","apa":"Pinotsis, N., Zielinska, K., Babuta, M., Arolas, J. L., Kostan, J., Khan, M. B., … Djinovic-Carugo, K. (2020). Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1917269117\">https://doi.org/10.1073/pnas.1917269117</a>","chicago":"Pinotsis, Nikos, Karolina Zielinska, Mrigya Babuta, Joan L. Arolas, Julius Kostan, Muhammad Bashir Khan, Claudia Schreiner, et al. “Calcium Modulates the Domain Flexibility and Function of an α-Actinin Similar to the Ancestral α-Actinin.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2020. <a href=\"https://doi.org/10.1073/pnas.1917269117\">https://doi.org/10.1073/pnas.1917269117</a>.","short":"N. Pinotsis, K. Zielinska, M. Babuta, J.L. Arolas, J. Kostan, M.B. Khan, C. Schreiner, A.P. Testa Salmazo, L. Ciccarelli, M. Puchinger, E.A. Gkougkoulia, E. de A. Ribeiro, T.C. Marlovits, A. Bhattacharya, K. Djinovic-Carugo, Proceedings of the National Academy of Sciences of the United States of America 117 (2020) 22101–22112.","mla":"Pinotsis, Nikos, et al. “Calcium Modulates the Domain Flexibility and Function of an α-Actinin Similar to the Ancestral α-Actinin.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 117, no. 36, National Academy of Sciences, 2020, pp. 22101–12, doi:<a href=\"https://doi.org/10.1073/pnas.1917269117\">10.1073/pnas.1917269117</a>."},"date_updated":"2026-06-18T17:45:21Z","intvolume":"       117","type":"journal_article","language":[{"iso":"eng"}],"publisher":"National Academy of Sciences","article_type":"original","external_id":{"pmid":["32848067"]},"author":[{"full_name":"Pinotsis, Nikos","first_name":"Nikos","last_name":"Pinotsis"},{"last_name":"Zielinska","first_name":"Karolina","full_name":"Zielinska, Karolina"},{"full_name":"Babuta, Mrigya","last_name":"Babuta","first_name":"Mrigya"},{"full_name":"Arolas, Joan L.","first_name":"Joan L.","last_name":"Arolas"},{"first_name":"Julius","last_name":"Kostan","full_name":"Kostan, Julius"},{"full_name":"Khan, Muhammad Bashir","first_name":"Muhammad Bashir","last_name":"Khan"},{"full_name":"Schreiner, Claudia","last_name":"Schreiner","first_name":"Claudia"},{"full_name":"Testa Salmazo, Anita P","first_name":"Anita P","id":"41F1F098-F248-11E8-B48F-1D18A9856A87","last_name":"Testa Salmazo"},{"first_name":"Luciano","last_name":"Ciccarelli","full_name":"Ciccarelli, Luciano"},{"full_name":"Puchinger, Martin","first_name":"Martin","last_name":"Puchinger"},{"last_name":"Gkougkoulia","first_name":"Eirini A.","full_name":"Gkougkoulia, Eirini A."},{"full_name":"Ribeiro, Euripedes de Almeida","first_name":"Euripedes de Almeida","last_name":"Ribeiro"},{"first_name":"Thomas C.","last_name":"Marlovits","full_name":"Marlovits, Thomas C."},{"full_name":"Bhattacharya, Alok","first_name":"Alok","last_name":"Bhattacharya"},{"full_name":"Djinovic-Carugo, Kristina","last_name":"Djinovic-Carugo","first_name":"Kristina"}],"department":[{"_id":"CaBe"}],"date_created":"2024-03-04T10:03:52Z","day":"08","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"status":"public","article_processing_charge":"No","pmid":1,"publication_status":"published","page":"22101-22112","_id":"15061","issue":"36","doi":"10.1073/pnas.1917269117","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1073/pnas.191726911"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledged_ssus":[{"_id":"LifeSc"}],"abstract":[{"text":"The actin cytoskeleton, a dynamic network of actin filaments and associated F-actin–binding proteins, is fundamentally important in eukaryotes. α-Actinins are major F-actin bundlers that are inhibited by Ca2+ in nonmuscle cells. Here we report the mechanism of Ca2+-mediated regulation of Entamoeba histolytica α-actinin-2 (EhActn2) with features expected for the common ancestor of Entamoeba and higher eukaryotic α-actinins. Crystal structures of Ca2+-free and Ca2+-bound EhActn2 reveal a calmodulin-like domain (CaMD) uniquely inserted within the rod domain. Integrative studies reveal an exceptionally high affinity of the EhActn2 CaMD for Ca2+, binding of which can only be regulated in the presence of physiological concentrations of Mg2+. Ca2+ binding triggers an increase in protein multidomain rigidity, reducing conformational flexibility of F-actin–binding domains via interdomain cross-talk and consequently inhibiting F-actin bundling. In vivo studies uncover that EhActn2 plays an important role in phagocytic cup formation and might constitute a new drug target for amoebic dysentery.","lang":"eng"}],"month":"09","acknowledgement":"We thank the staff of the macromolecular crystallography (MX) and SAXS beamlines at the European Synchrotron Radiation facility, Diamond, and Swiss Light Source for excellent support, and the Life Sciences Facility of the Institute of Science and Technology Austria for usage of the rheometer. We thank Life Sciences editors for editing assistance. EM data were\r\nrecorded at the EM Facility of the Vienna BioCenter Core Facilities (Austria). Confocal microscopy was carried out at the Advanced Instrument Research Facility, Jawaharlal Nehru University. K.D.-C.’s research was supported by the Initial Training Network MUZIC (ITN-MUZIC) (N°238423), Austrian Science Fund (FWF) Projects I525, I1593, P22276, P19060, and W1221, Laura Bassi Centre of Optimized Structural Studies (N°253275), a Wellcome Trust Collaborative Award (201543/Z/16/Z), COST Action BM1405, Vienna Science and Technology Fund (WWTF) Chemical Biology Project LS17-008, and Christian Doppler Laboratory for High-Content Structural Biology and Biotechnology. K.Z., J.L.A., C.S., E.A.G., and A.S. were supported by the University of Vienna, J.K. by a Wellcome Trust Collaborative Award and by the Centre of Optimized Structural Studies, M.P. by FWF Project I1593, E.d.A.R. ITN-MUZIC, and FWF Projects I525 and I1593, and T.C.M. and L.C. by FWF Project I 2408-B22. E.A.G. acknowledges the PhD program Structure and Interaction of Biological Macromolecules. M.B. acknowledges the University Grant Commission, India, for a senior research fellowship. A.B. acknowledges a JC Bose Fellowship from the Science Engineering Research Council. ","oa":1,"oa_version":"Published Version","ddc":["570"],"year":"2020","title":"Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin","volume":117,"publication":"Proceedings of the National Academy of Sciences of the United States of America"}]