[{"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","oa":1,"ddc":["005"],"citation":{"mla":"Guzmán, José, et al. <i>How Connectivity Rules and Synaptic Properties Shape the Efficacy of Pattern Separation in the Entorhinal Cortex–Dentate Gyrus–CA3 Network</i>. IST Austria, 2021, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10110\">10.15479/AT:ISTA:10110</a>.","apa":"Guzmán, J., Schlögl, A., Espinoza Martinez, C., Zhang, X., Suter, B., &#38; Jonas, P. M. (2021). How connectivity rules and synaptic properties shape the efficacy of pattern separation in the entorhinal cortex–dentate gyrus–CA3 network. IST Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:10110\">https://doi.org/10.15479/AT:ISTA:10110</a>","ama":"Guzmán J, Schlögl A, Espinoza Martinez C, Zhang X, Suter B, Jonas PM. How connectivity rules and synaptic properties shape the efficacy of pattern separation in the entorhinal cortex–dentate gyrus–CA3 network. 2021. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:10110\">10.15479/AT:ISTA:10110</a>","ista":"Guzmán J, Schlögl A, Espinoza Martinez C, Zhang X, Suter B, Jonas PM. 2021. How connectivity rules and synaptic properties shape the efficacy of pattern separation in the entorhinal cortex–dentate gyrus–CA3 network, IST Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:10110\">10.15479/AT:ISTA:10110</a>.","ieee":"J. Guzmán, A. Schlögl, C. Espinoza Martinez, X. Zhang, B. Suter, and P. M. Jonas, “How connectivity rules and synaptic properties shape the efficacy of pattern separation in the entorhinal cortex–dentate gyrus–CA3 network.” IST Austria, 2021.","chicago":"Guzmán, José, Alois Schlögl, Claudia  Espinoza Martinez, Xiaomin Zhang, Benjamin Suter, and Peter M Jonas. “How Connectivity Rules and Synaptic Properties Shape the Efficacy of Pattern Separation in the Entorhinal Cortex–Dentate Gyrus–CA3 Network.” IST Austria, 2021. <a href=\"https://doi.org/10.15479/AT:ISTA:10110\">https://doi.org/10.15479/AT:ISTA:10110</a>.","short":"J. Guzmán, A. Schlögl, C. Espinoza Martinez, X. Zhang, B. Suter, P.M. Jonas, (2021)."},"doi":"10.15479/AT:ISTA:10110","publisher":"IST Austria","has_accepted_license":"1","title":"How connectivity rules and synaptic properties shape the efficacy of pattern separation in the entorhinal cortex–dentate gyrus–CA3 network","license":"https://opensource.org/licenses/GPL-3.0","tmp":{"name":"GNU General Public License 3.0","short":"GPL 3.0","legal_code_url":"https://www.gnu.org/licenses/gpl-3.0.en.html"},"type":"software","department":[{"_id":"PeJo"},{"_id":"ScienComp"}],"author":[{"id":"30CC5506-F248-11E8-B48F-1D18A9856A87","last_name":"Guzmán","first_name":"José","orcid":"0000-0003-2209-5242","full_name":"Guzmán, José"},{"full_name":"Schlögl, Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","last_name":"Schlögl","first_name":"Alois","orcid":"0000-0002-5621-8100"},{"full_name":"Espinoza Martinez, Claudia ","first_name":"Claudia ","orcid":"0000-0003-4710-2082","id":"31FFEE2E-F248-11E8-B48F-1D18A9856A87","last_name":"Espinoza Martinez"},{"full_name":"Zhang, Xiaomin","id":"423EC9C2-F248-11E8-B48F-1D18A9856A87","last_name":"Zhang","first_name":"Xiaomin","orcid":"0000-0003-0256-6529"},{"full_name":"Suter, Benjamin","last_name":"Suter","id":"4952F31E-F248-11E8-B48F-1D18A9856A87","first_name":"Benjamin","orcid":"0000-0002-9885-6936"},{"orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","full_name":"Jonas, Peter M"}],"_id":"10110","month":"12","related_material":{"record":[{"id":"10816","relation":"used_for_analysis_in","status":"public"}],"link":[{"description":"News on IST Webpage","url":"https://ist.ac.at/en/news/spot-the-difference/","relation":"press_release"}]},"date_created":"2021-10-08T06:44:22Z","status":"public","date_updated":"2026-11-12T23:30:48Z","day":"16","fulldoi":"https://doi.org/10.15479/AT:ISTA:10110","file":[{"date_created":"2021-10-08T08:46:04Z","date_updated":"2021-10-08T08:46:04Z","creator":"cchlebak","success":1,"file_size":332990101,"file_name":"patternseparation-main (1).zip","checksum":"f92f8931cad0aa7e411c1715337bf408","file_id":"10114","content_type":"application/x-zip-compressed","relation":"main_file","access_level":"open_access"}],"file_date_updated":"2021-10-08T08:46:04Z","date_published":"2021-12-16T00:00:00Z","abstract":[{"lang":"eng","text":"Pattern separation is a fundamental brain computation that converts small differences in input patterns into large differences in output patterns. Several synaptic mechanisms of pattern separation have been proposed, including code expansion, inhibition and plasticity; however, which of these mechanisms play a role in the entorhinal cortex (EC)–dentate gyrus (DG)–CA3 circuit, a classical pattern separation circuit, remains unclear. Here we show that a biologically realistic, full-scale EC–DG–CA3 circuit model, including granule cells (GCs) and parvalbumin-positive inhibitory interneurons (PV+-INs) in the DG, is an efficient pattern separator. Both external gamma-modulated inhibition and internal lateral inhibition mediated by PV+-INs substantially contributed to pattern separation. Both local connectivity and fast signaling at GC–PV+-IN synapses were important for maximum effectiveness. Similarly, mossy fiber synapses with conditional detonator properties contributed to pattern separation. By contrast, perforant path synapses with Hebbian synaptic plasticity and direct EC–CA3 connection shifted the network towards pattern completion. Our results demonstrate that the specific properties of cells and synapses optimize higher-order computations in biological networks and might be useful to improve the deep learning capabilities of technical networks."}],"year":"2021"},{"author":[{"full_name":"Goharshady, Amir Kafshdar","id":"391365CE-F248-11E8-B48F-1D18A9856A87","last_name":"Goharshady","orcid":"0000-0003-1702-6584","first_name":"Amir Kafshdar"}],"month":"01","degree_awarded":"PhD","date_created":"2020-12-10T12:17:07Z","tmp":{"image":"/images/cc_0.png","name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","short":"CC0 (1.0)"},"type":"dissertation","OA_place":"publisher","day":"01","fulldoi":"https://doi.org/10.15479/AT:ISTA:8934","file_date_updated":"2021-12-23T23:30:04Z","publication_status":"published","date_published":"2021-01-01T00:00:00Z","title":"Parameterized and algebro-geometric advances in static program analysis","license":"https://creativecommons.org/publicdomain/zero/1.0/","publication_identifier":{"issn":["2663-337X"]},"citation":{"mla":"Goharshady, Amir Kafshdar. <i>Parameterized and Algebro-Geometric Advances in Static Program Analysis</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8934\">10.15479/AT:ISTA:8934</a>.","apa":"Goharshady, A. K. (2021). <i>Parameterized and algebro-geometric advances in static program analysis</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8934\">https://doi.org/10.15479/AT:ISTA:8934</a>","ista":"Goharshady AK. 2021. Parameterized and algebro-geometric advances in static program analysis. Institute of Science and Technology Austria.","ama":"Goharshady AK. Parameterized and algebro-geometric advances in static program analysis. 2021. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8934\">10.15479/AT:ISTA:8934</a>","ieee":"A. K. Goharshady, “Parameterized and algebro-geometric advances in static program analysis,” Institute of Science and Technology Austria, 2021.","chicago":"Goharshady, Amir Kafshdar. “Parameterized and Algebro-Geometric Advances in Static Program Analysis.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/AT:ISTA:8934\">https://doi.org/10.15479/AT:ISTA:8934</a>.","short":"A.K. Goharshady, Parameterized and Algebro-Geometric Advances in Static Program Analysis, Institute of Science and Technology Austria, 2021."},"doi":"10.15479/AT:ISTA:8934","page":"278","_id":"8934","article_processing_charge":"No","related_material":{"record":[{"relation":"part_of_dissertation","id":"6490","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"6780"},{"status":"public","id":"7158","relation":"part_of_dissertation"},{"status":"public","id":"66","relation":"part_of_dissertation"},{"status":"public","id":"6378","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"311"},{"id":"6175","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"6340"},{"relation":"part_of_dissertation","id":"7014","status":"public"},{"relation":"part_of_dissertation","id":"6009","status":"public"},{"id":"1437","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","id":"8728","status":"public"},{"status":"public","id":"8089","relation":"part_of_dissertation"},{"status":"public","id":"6380","relation":"part_of_dissertation"},{"id":"5977","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"6056","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"639"},{"status":"public","id":"1386","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"6918","status":"public"},{"status":"public","id":"7810","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"949"}]},"status":"public","date_updated":"2026-04-16T10:07:18Z","department":[{"_id":"KrCh"},{"_id":"GradSch"}],"language":[{"iso":"eng"}],"oa_version":"Published Version","year":"2021","project":[{"name":"Quantitative Analysis of Probabilistic Systems with a focus on Crypto-Currencies","_id":"267066CE-B435-11E9-9278-68D0E5697425"},{"_id":"266EEEC0-B435-11E9-9278-68D0E5697425","name":"Quantitative Game-theoretic Analysis of Blockchain Applications and Smart Contracts"}],"file":[{"file_name":"Thesis-pdfa.pdf","embargo":"2021-12-22","file_size":5251507,"date_updated":"2021-12-23T23:30:04Z","date_created":"2020-12-22T20:08:44Z","creator":"akafshda","relation":"main_file","access_level":"open_access","checksum":"d1b9db3725aed34dadd81274aeb9426c","file_id":"8969","content_type":"application/pdf"},{"access_level":"closed","relation":"source_file","content_type":"application/zip","file_id":"8970","checksum":"1661df7b393e6866d2460eba3c905130","file_name":"source.zip","file_size":10636756,"embargo_to":"open_access","creator":"akafshda","date_created":"2020-12-22T20:08:50Z","date_updated":"2021-03-04T23:30:04Z"}],"corr_author":"1","abstract":[{"lang":"eng","text":"In this thesis, we consider several of the most classical and fundamental problems in static analysis and formal verification, including invariant generation, reachability analysis, termination analysis of probabilistic programs, data-flow analysis, quantitative analysis of Markov chains and Markov decision processes, and the problem of data packing in cache management.\r\nWe use techniques from parameterized complexity theory, polyhedral geometry, and real algebraic geometry to significantly improve the state-of-the-art, in terms of both scalability and completeness guarantees, for the mentioned problems. In some cases, our results are the first theoretical improvements for the respective problems in two or three decades."}],"acknowledgement":"The research was partially supported by an IBM PhD fellowship, a Facebook PhD fellowship, and DOC fellowship #24956 of the Austrian Academy of Sciences (OeAW).","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"ddc":["005"],"has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","supervisor":[{"full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"}],"alternative_title":["ISTA Thesis"]},{"publisher":"Institute of Science and Technology Austria","has_accepted_license":"1","alternative_title":["ISTA Thesis"],"supervisor":[{"last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87","first_name":"Simon","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"ddc":["570"],"project":[{"name":"Molecular mechanisms of radial neuronal migration","grant_number":"24812","_id":"2625A13E-B435-11E9-9278-68D0E5697425"}],"file":[{"file_size":10629190,"file_name":"Thesis_Hansen.docx","date_created":"2021-08-30T09:17:39Z","date_updated":"2022-09-03T22:30:04Z","embargo_to":"open_access","creator":"ahansen","relation":"source_file","access_level":"closed","checksum":"66b56f5b988b233dc66a4f4b4fb2cdfe","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"9971"},{"date_created":"2021-08-30T09:29:44Z","date_updated":"2022-09-03T22:30:04Z","creator":"ahansen","file_size":13457469,"file_name":"Thesis_Hansen_PDFA-1a.pdf","embargo":"2022-09-02","checksum":"204fa40321a1c6289b68c473634c4bf3","content_type":"application/pdf","file_id":"9972","relation":"main_file","access_level":"open_access"}],"corr_author":"1","abstract":[{"text":"The brain is one of the largest and most complex organs and it is composed of billions of neurons that communicate together enabling e.g. consciousness. The cerebral cortex is the largest site of neural integration in the central nervous system. Concerted radial migration of newly born cortical projection neurons, from their birthplace to their final position, is a key step in the assembly of the cerebral cortex. The cellular and molecular mechanisms regulating radial neuronal migration in vivo are however still unclear. Recent evidence suggests that distinct signaling cues act cell-autonomously but differentially at certain steps during the overall migration process. Moreover, functional analysis of genetic mosaics (mutant neurons present in wild-type/heterozygote environment) using the MADM (Mosaic Analysis with Double Markers) analyses in comparison to global knockout also indicate a significant degree of non-cell-autonomous and/or community effects in the control of cortical neuron migration. The interactions of cell-intrinsic (cell-autonomous) and cell-extrinsic (non-cell-autonomous) components are largely unknown. In part of this thesis work we established a MADM-based experimental strategy for the quantitative analysis of cell-autonomous gene function versus non-cell-autonomous and/or community effects. The direct comparison of mutant neurons from the genetic mosaic (cell-autonomous) to mutant neurons in the conditional and/or global knockout (cell-autonomous + non-cell-autonomous) allows to quantitatively analyze non-cell-autonomous effects. Such analysis enable the high-resolution analysis of projection neuron migration dynamics in distinct environments with concomitant isolation of genomic and proteomic profiles. Using these experimental paradigms and in combination with computational modeling we show and characterize the nature of non-cell-autonomous effects to coordinate radial neuron migration. Furthermore, this thesis discusses recent developments in neurodevelopment with focus on neuronal polarization and non-cell-autonomous mechanisms in neuronal migration.","lang":"eng"}],"language":[{"iso":"eng"}],"oa_version":"Published Version","year":"2021","keyword":["Neuronal migration","Non-cell-autonomous","Cell-autonomous","Neurodevelopmental disease"],"department":[{"_id":"GradSch"},{"_id":"SiHi"}],"page":"182","_id":"9962","article_processing_charge":"No","date_updated":"2026-04-08T07:19:09Z","status":"public","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"8569"},{"id":"960","relation":"part_of_dissertation","status":"public"}]},"citation":{"chicago":"Hansen, Andi H. “Cell-Autonomous Gene Function and Non-Cell-Autonomous Effects in Radial Projection Neuron Migration.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:9962\">https://doi.org/10.15479/at:ista:9962</a>.","short":"A.H. Hansen, Cell-Autonomous Gene Function and Non-Cell-Autonomous Effects in Radial Projection Neuron Migration, Institute of Science and Technology Austria, 2021.","apa":"Hansen, A. H. (2021). <i>Cell-autonomous gene function and non-cell-autonomous effects in radial projection neuron migration</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:9962\">https://doi.org/10.15479/at:ista:9962</a>","ista":"Hansen AH. 2021. Cell-autonomous gene function and non-cell-autonomous effects in radial projection neuron migration. Institute of Science and Technology Austria.","ama":"Hansen AH. Cell-autonomous gene function and non-cell-autonomous effects in radial projection neuron migration. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:9962\">10.15479/at:ista:9962</a>","mla":"Hansen, Andi H. <i>Cell-Autonomous Gene Function and Non-Cell-Autonomous Effects in Radial Projection Neuron Migration</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:9962\">10.15479/at:ista:9962</a>.","ieee":"A. H. Hansen, “Cell-autonomous gene function and non-cell-autonomous effects in radial projection neuron migration,” Institute of Science and Technology Austria, 2021."},"publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/at:ista:9962","title":"Cell-autonomous gene function and non-cell-autonomous effects in radial projection neuron migration","day":"02","fulldoi":"https://doi.org/10.15479/at:ista:9962","file_date_updated":"2022-09-03T22:30:04Z","date_published":"2021-09-02T00:00:00Z","publication_status":"published","OA_place":"publisher","type":"dissertation","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"author":[{"full_name":"Hansen, Andi H","first_name":"Andi H","id":"38853E16-F248-11E8-B48F-1D18A9856A87","last_name":"Hansen"}],"month":"09","degree_awarded":"PhD","date_created":"2021-08-29T12:36:50Z"},{"month":"06","author":[{"id":"42E121A4-F248-11E8-B48F-1D18A9856A87","last_name":"Kleindienst","first_name":"David","full_name":"Kleindienst, David"}],"date_created":"2021-06-17T14:10:47Z","degree_awarded":"PhD","acknowledged_ssus":[{"_id":"EM-Fac"}],"type":"dissertation","OA_place":"publisher","fulldoi":"https://doi.org/10.15479/at:ista:9562","day":"01","file_date_updated":"2022-07-02T22:30:04Z","publication_status":"published","date_published":"2021-06-01T00:00:00Z","title":"2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning","publication_identifier":{"issn":["2663-337X"]},"citation":{"chicago":"Kleindienst, David. “2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:9562\">https://doi.org/10.15479/at:ista:9562</a>.","short":"D. Kleindienst, 2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning, Institute of Science and Technology Austria, 2021.","apa":"Kleindienst, D. (2021). <i>2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:9562\">https://doi.org/10.15479/at:ista:9562</a>","ama":"Kleindienst D. 2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:9562\">10.15479/at:ista:9562</a>","ista":"Kleindienst D. 2021. 2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning. Institute of Science and Technology Austria.","mla":"Kleindienst, David. <i>2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:9562\">10.15479/at:ista:9562</a>.","ieee":"D. Kleindienst, “2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning,” Institute of Science and Technology Austria, 2021."},"doi":"10.15479/at:ista:9562","_id":"9562","page":"124","date_updated":"2026-07-06T13:11:44Z","status":"public","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"9437"},{"status":"public","relation":"part_of_dissertation","id":"612"},{"id":"8532","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"9756"}]},"article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"RySh"}],"oa_version":"Published Version","language":[{"iso":"eng"}],"year":"2021","abstract":[{"text":"Left-right asymmetries can be considered a fundamental organizational principle of the vertebrate central nervous system. The hippocampal CA3-CA1 pyramidal cell synaptic connection shows an input-side dependent asymmetry where the hemispheric location of the presynaptic CA3 neuron determines the synaptic properties. Left-input synapses terminating on apical dendrites in stratum radiatum have a higher density of NMDA receptor subunit GluN2B, a lower density of AMPA receptor subunit GluA1 and smaller areas with less often perforated PSDs. On the other hand, left-input synapses terminating on basal dendrites in stratum oriens have lower GluN2B densities than right-input ones. Apical and basal synapses further employ different signaling pathways involved in LTP. SDS-digested freeze-fracture replica labeling can visualize synaptic membrane proteins with high sensitivity and resolution, and has been used to reveal the asymmetry at the electron microscopic level. However, it requires time-consuming manual demarcation of the synaptic surface for quantitative measurements. To facilitate the analysis of replica labeling, I first developed a software named Darea, which utilizes deep-learning to automatize this demarcation. With Darea I characterized the synaptic distribution of NMDA and AMPA receptors as well as the voltage-gated Ca2+ channels in CA1 stratum radiatum and oriens. Second, I explored the role of GluN2B and its carboxy-terminus in the establishment of input-side dependent hippocampal asymmetry. In conditional knock-out mice lacking GluN2B expression in CA1 and GluN2B-2A swap mice, where GluN2B carboxy-terminus was exchanged to that of GluN2A, no significant asymmetries of GluN2B, GluA1 and PSD area were detected. We further discovered a previously unknown functional asymmetry of GluN2A, which was also lost in the swap mouse. These results demonstrate that GluN2B carboxy-terminus plays a critical role in normal formation of input-side dependent asymmetry.","lang":"eng"}],"corr_author":"1","file":[{"access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"9563","checksum":"659df5518db495f679cb1df9e9bd1d94","file_name":"Thesis.pdf","embargo":"2022-07-01","file_size":77299142,"creator":"dkleindienst","date_created":"2021-06-17T14:03:14Z","date_updated":"2022-07-02T22:30:04Z"},{"access_level":"closed","relation":"source_file","file_id":"9564","content_type":"application/zip","checksum":"3bcf63a2b19e5b6663be051bea332748","file_name":"Thesis_source.zip","file_size":369804895,"creator":"dkleindienst","embargo_to":"open_access","date_updated":"2022-07-02T22:30:04Z","date_created":"2021-06-17T14:04:30Z"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"ddc":["570"],"has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","alternative_title":["ISTA Thesis"],"supervisor":[{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"}]},{"type":"book_chapter","ec_funded":1,"author":[{"id":"3F99E422-F248-11E8-B48F-1D18A9856A87","last_name":"Kaufmann","orcid":"0000-0001-9735-5315","first_name":"Walter","full_name":"Kaufmann, Walter"},{"full_name":"Kleindienst, David","last_name":"Kleindienst","id":"42E121A4-F248-11E8-B48F-1D18A9856A87","first_name":"David"},{"orcid":"0000-0001-7429-7896","first_name":"Harumi","id":"2E55CDF2-F248-11E8-B48F-1D18A9856A87","last_name":"Harada","full_name":"Harada, Harumi"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"}],"month":"07","date_created":"2021-07-30T09:34:56Z","day":"27","fulldoi":"https://doi.org/10.1007/978-1-0716-1522-5_19","publication_status":"published","date_published":"2021-07-27T00:00:00Z","scopus_import":"1","das_tickbox":"1","quality_controlled":"1","citation":{"ieee":"W. Kaufmann, D. Kleindienst, H. Harada, and R. Shigemoto, “High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL),” in <i>Receptor and Ion Channel Detection in the Brain</i>, vol. 169, New York: Humana Press, 2021, pp. 267–283.","mla":"Kaufmann, Walter, et al. “High-Resolution Localization and Quantitation of Membrane Proteins by SDS-Digested Freeze-Fracture Replica Labeling (SDS-FRL).” <i>Receptor and Ion Channel Detection in the Brain</i>, vol. 169, Humana Press, 2021, pp. 267–83, doi:<a href=\"https://doi.org/10.1007/978-1-0716-1522-5_19\">10.1007/978-1-0716-1522-5_19</a>.","ista":"Kaufmann W, Kleindienst D, Harada H, Shigemoto R. 2021.High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL). In: Receptor and Ion Channel Detection in the Brain. Neuromethods, vol. 169, 267–283.","apa":"Kaufmann, W., Kleindienst, D., Harada, H., &#38; Shigemoto, R. (2021). High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL). In <i>Receptor and Ion Channel Detection in the Brain</i> (Vol. 169, pp. 267–283). New York: Humana Press. <a href=\"https://doi.org/10.1007/978-1-0716-1522-5_19\">https://doi.org/10.1007/978-1-0716-1522-5_19</a>","ama":"Kaufmann W, Kleindienst D, Harada H, Shigemoto R. High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL). In: <i>Receptor and Ion Channel Detection in the Brain</i>. Vol 169. Neuromethods. New York: Humana Press; 2021:267-283. doi:<a href=\"https://doi.org/10.1007/978-1-0716-1522-5_19\">10.1007/978-1-0716-1522-5_19</a>","short":"W. Kaufmann, D. Kleindienst, H. Harada, R. Shigemoto, in:, Receptor and Ion Channel Detection in the Brain, Humana Press, New York, 2021, pp. 267–283.","chicago":"Kaufmann, Walter, David Kleindienst, Harumi Harada, and Ryuichi Shigemoto. “High-Resolution Localization and Quantitation of Membrane Proteins by SDS-Digested Freeze-Fracture Replica Labeling (SDS-FRL).” In <i>Receptor and Ion Channel Detection in the Brain</i>, 169:267–83. Neuromethods. New York: Humana Press, 2021. <a href=\"https://doi.org/10.1007/978-1-0716-1522-5_19\">https://doi.org/10.1007/978-1-0716-1522-5_19</a>."},"publication_identifier":{"isbn":["9781071615218"],"eisbn":["9781071615225"]},"doi":"10.1007/978-1-0716-1522-5_19","title":"High-Resolution localization and quantitation of membrane proteins by SDS-digested freeze-fracture replica labeling (SDS-FRL)","publication":"Receptor and Ion Channel Detection in the Brain","department":[{"_id":"RySh"},{"_id":"EM-Fac"}],"intvolume":"       169","page":"267-283","_id":"9756","article_processing_charge":"No","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"9562"}]},"status":"public","date_updated":"2026-11-12T23:30:56Z","project":[{"call_identifier":"H2020","_id":"25CA28EA-B435-11E9-9278-68D0E5697425","grant_number":"694539","name":"In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour"},{"grant_number":"720270","name":"Human Brain Project Specific Grant Agreement 1","_id":"25CBA828-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"abstract":[{"lang":"eng","text":"High-resolution visualization and quantification of membrane proteins contribute to the understanding of their functions and the roles they play in physiological and pathological conditions. Sodium dodecyl sulfate-digested freeze-fracture replica labeling (SDS-FRL) is a powerful electron microscopy method to study quantitatively the two-dimensional distribution of transmembrane proteins and their tightly associated proteins. During treatment with SDS, intracellular organelles and proteins not anchored to the replica are dissolved, whereas integral membrane proteins captured and stabilized by carbon/platinum deposition remain on the replica. Their intra- and extracellular domains become exposed on the surface of the replica, facilitating the accessibility of antibodies and, therefore, providing higher labeling efficiency than those obtained with other immunoelectron microscopy techniques. In this chapter, we describe the protocols of SDS-FRL adapted for mammalian brain samples, and optimization of the SDS treatment to increase the labeling efficiency for quantification of Cav2.1, the alpha subunit of P/Q-type voltage-dependent calcium channels utilizing deep learning algorithms."}],"corr_author":"1","language":[{"iso":"eng"}],"oa_version":"None","volume":169,"year":"2021","keyword":["Freeze-fracture replica: Deep learning","Immunogold labeling","Integral membrane protein","Electron microscopy"],"acknowledgement":"This work was supported by the European Union (European Research Council Advanced grant no. 694539 and Human Brain Project Ref. 720270 to R. S.) and the Austrian Academy of Sciences (DOC fellowship to D.K.).","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["573"],"place":"New York","has_accepted_license":"1","publisher":"Humana Press","series_title":"Neuromethods","alternative_title":["Neuromethods"]},{"external_id":{"arxiv":["2103.00023"],"isi":["000720926900019"],"pmid":[" 34732570"]},"keyword":["multidisciplinary","elastoinertial turbulence","viscoelastic flows","elastic instability","drag reduction"],"volume":118,"year":"2021","oa_version":"Preprint","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Turbulence generally arises in shear flows if velocities and hence, inertial forces are sufficiently large. In striking contrast, viscoelastic fluids can exhibit disordered motion even at vanishing inertia. Intermediate between these cases, a state of chaotic motion, “elastoinertial turbulence” (EIT), has been observed in a narrow Reynolds number interval. We here determine the origin of EIT in experiments and show that characteristic EIT structures can be detected across an unexpectedly wide range of parameters. Close to onset, a pattern of chevron-shaped streaks emerges in qualitative agreement with linear and weakly nonlinear theory. However, in experiments, the dynamics remain weakly chaotic, and the instability can be traced to far lower Reynolds numbers than permitted by theory. For increasing inertia, the flow undergoes a transformation to a wall mode composed of inclined near-wall streaks and shear layers. This mode persists to what is known as the “maximum drag reduction limit,” and overall EIT is found to dominate viscoelastic flows across more than three orders of magnitude in Reynolds number."}],"corr_author":"1","project":[{"call_identifier":"FWF","_id":"238B8092-32DE-11EA-91FC-C7463DDC885E","grant_number":"I04188","name":"Instabilities in pulsating pipe flow in complex fluids"}],"isi":1,"date_updated":"2026-11-12T23:30:57Z","status":"public","related_material":{"record":[{"id":"19906","relation":"dissertation_contains","status":"public"}]},"article_processing_charge":"No","_id":"10299","intvolume":"       118","department":[{"_id":"BjHo"}],"publisher":"National Academy of Sciences","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We thank Y. Dubief, R. Kerswell, E. Marensi, V. Shankar, V. Steinberg, and V. Terrapon for discussions and helpful comments. A.V. and B.H. acknowledge funding from the Austrian Science Fund, grant I4188-N30, within the Deutsche Forschungsgemeinschaft research unit FOR 2688.","scopus_import":"1","article_type":"original","date_published":"2021-11-03T00:00:00Z","publication_status":"published","fulldoi":"https://doi.org/10.1073/pnas.2102350118","day":"03","date_created":"2021-11-17T13:24:24Z","article_number":"e2102350118","month":"11","author":[{"first_name":"George H","id":"448BD5BC-F248-11E8-B48F-1D18A9856A87","last_name":"Choueiri","full_name":"Choueiri, George H"},{"id":"40770848-F248-11E8-B48F-1D18A9856A87","last_name":"Lopez Alonso","first_name":"Jose M","orcid":"0000-0002-0384-2022","full_name":"Lopez Alonso, Jose M"},{"full_name":"Varshney, Atul","id":"2A2006B2-F248-11E8-B48F-1D18A9856A87","last_name":"Varshney","orcid":"0000-0002-3072-5999","first_name":"Atul"},{"full_name":"Sankar, Sarath","last_name":"Sankar","first_name":"Sarath"},{"first_name":"Björn","orcid":"0000-0003-2057-2754","last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn"}],"type":"journal_article","publication":"Proceedings of the National Academy of Sciences of the United States of America","main_file_link":[{"url":"https://arxiv.org/abs/2103.00023","open_access":"1"}],"title":"Experimental observation of the origin and structure of elastoinertial turbulence","doi":"10.1073/pnas.2102350118","arxiv":1,"citation":{"short":"G.H. Choueiri, J.M. Lopez Alonso, A. Varshney, S. Sankar, B. Hof, Proceedings of the National Academy of Sciences of the United States of America 118 (2021).","chicago":"Choueiri, George H, Jose M Lopez Alonso, Atul Varshney, Sarath Sankar, and Björn Hof. “Experimental Observation of the Origin and Structure of Elastoinertial Turbulence.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2021. <a href=\"https://doi.org/10.1073/pnas.2102350118\">https://doi.org/10.1073/pnas.2102350118</a>.","ieee":"G. H. Choueiri, J. M. Lopez Alonso, A. Varshney, S. Sankar, and B. Hof, “Experimental observation of the origin and structure of elastoinertial turbulence,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 118, no. 45. National Academy of Sciences, 2021.","apa":"Choueiri, G. H., Lopez Alonso, J. M., Varshney, A., Sankar, S., &#38; Hof, B. (2021). Experimental observation of the origin and structure of elastoinertial turbulence. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2102350118\">https://doi.org/10.1073/pnas.2102350118</a>","ista":"Choueiri GH, Lopez Alonso JM, Varshney A, Sankar S, Hof B. 2021. Experimental observation of the origin and structure of elastoinertial turbulence. Proceedings of the National Academy of Sciences of the United States of America. 118(45), e2102350118.","ama":"Choueiri GH, Lopez Alonso JM, Varshney A, Sankar S, Hof B. Experimental observation of the origin and structure of elastoinertial turbulence. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2021;118(45). doi:<a href=\"https://doi.org/10.1073/pnas.2102350118\">10.1073/pnas.2102350118</a>","mla":"Choueiri, George H., et al. “Experimental Observation of the Origin and Structure of Elastoinertial Turbulence.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 118, no. 45, e2102350118, National Academy of Sciences, 2021, doi:<a href=\"https://doi.org/10.1073/pnas.2102350118\">10.1073/pnas.2102350118</a>."},"publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"quality_controlled":"1","pmid":1,"issue":"45"},{"oa":1,"ddc":["530"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We would like to thank D. Abanin and R. Medina for fruitful discussions and A. Smith and I. Kim for valuable feedback on the manuscript. We acknowledge support by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).","publisher":"Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften","has_accepted_license":"1","date_updated":"2026-11-12T23:31:01Z","status":"public","related_material":{"record":[{"status":"public","id":"14622","relation":"dissertation_contains"}]},"article_processing_charge":"Yes","_id":"9760","intvolume":"         5","department":[{"_id":"GradSch"},{"_id":"MaSe"}],"external_id":{"isi":["000669830600001"],"arxiv":["2101.05742"]},"volume":5,"year":"2021","oa_version":"Published Version","language":[{"iso":"eng"}],"corr_author":"1","abstract":[{"lang":"eng","text":"The quantum approximate optimization algorithm (QAOA) is a prospective near-term quantum algorithm due to its modest circuit depth and promising benchmarks. However, an external parameter optimization required in the QAOA could become a performance bottleneck. This motivates studies of the optimization landscape and search for heuristic ways of parameter initialization. In this work we visualize the optimization landscape of the QAOA applied to the MaxCut problem on random graphs, demonstrating that random initialization of the QAOA is prone to converging to local minima with suboptimal performance. We introduce the initialization of QAOA parameters based on the Trotterized quantum annealing (TQA) protocol, parameterized by the Trotter time step. We find that the TQA initialization allows to circumvent\r\nthe issue of false minima for a broad range of time steps, yielding the same performance as the best result out of an exponentially scaling number of random initializations. Moreover, we demonstrate that the optimal value of the time step coincides with the point of proliferation of Trotter errors in quantum annealing. Our results suggest practical ways of initializing QAOA protocols on near-term quantum devices and reveal new connections between QAOA and quantum annealing."}],"file":[{"file_size":2312482,"file_name":"2021_Quantum_Sack.pdf","date_created":"2021-08-06T06:44:31Z","date_updated":"2021-08-06T06:44:31Z","creator":"cchlebak","relation":"main_file","access_level":"open_access","checksum":"9706c2bb8e748e9b5b138381995a7f6f","content_type":"application/pdf","file_id":"9774"}],"isi":1,"project":[{"grant_number":"850899","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control","_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","call_identifier":"H2020"}],"quality_controlled":"1","publication":"Quantum","title":"Quantum annealing initialization of the quantum approximate optimization algorithm","doi":"10.22331/Q-2021-07-01-491","arxiv":1,"citation":{"ieee":"S. Sack and M. Serbyn, “Quantum annealing initialization of the quantum approximate optimization algorithm,” <i>Quantum</i>, vol. 5. Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften, 2021.","mla":"Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the Quantum Approximate Optimization Algorithm.” <i>Quantum</i>, vol. 5, 491, Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften, 2021, doi:<a href=\"https://doi.org/10.22331/Q-2021-07-01-491\">10.22331/Q-2021-07-01-491</a>.","ama":"Sack S, Serbyn M. Quantum annealing initialization of the quantum approximate optimization algorithm. <i>Quantum</i>. 2021;5. doi:<a href=\"https://doi.org/10.22331/Q-2021-07-01-491\">10.22331/Q-2021-07-01-491</a>","ista":"Sack S, Serbyn M. 2021. Quantum annealing initialization of the quantum approximate optimization algorithm. Quantum. 5, 491.","apa":"Sack, S., &#38; Serbyn, M. (2021). Quantum annealing initialization of the quantum approximate optimization algorithm. <i>Quantum</i>. Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften. <a href=\"https://doi.org/10.22331/Q-2021-07-01-491\">https://doi.org/10.22331/Q-2021-07-01-491</a>","short":"S. Sack, M. Serbyn, Quantum 5 (2021).","chicago":"Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the Quantum Approximate Optimization Algorithm.” <i>Quantum</i>. Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften, 2021. <a href=\"https://doi.org/10.22331/Q-2021-07-01-491\">https://doi.org/10.22331/Q-2021-07-01-491</a>."},"publication_identifier":{"eissn":["2521-327X"]},"date_created":"2021-08-01T22:01:21Z","article_number":"491","month":"07","author":[{"first_name":"Stefan","orcid":"0000-0001-5400-8508","id":"dd622248-f6e0-11ea-865d-ce382a1c81a5","last_name":"Sack","full_name":"Sack, Stefan"},{"orcid":"0000-0002-2399-5827","first_name":"Maksym","last_name":"Serbyn","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","full_name":"Serbyn, Maksym"}],"ec_funded":1,"type":"journal_article","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"scopus_import":"1","article_type":"original","publication_status":"published","date_published":"2021-07-01T00:00:00Z","file_date_updated":"2021-08-06T06:44:31Z","fulldoi":"https://doi.org/10.22331/Q-2021-07-01-491","day":"01"},{"publisher":"Oxford University Press","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"The authors thank IT support at IST Austria for providing an optimal environment for bioinformatic analyses. This work was supported by an Austrian Science Foundation FWF grant (Project P28842) to B.V.","oa":1,"ddc":["610"],"oa_version":"Published Version","language":[{"iso":"eng"}],"external_id":{"pmid":["34146097"],"isi":["000741368600009"]},"keyword":["sex chromosomes","evolutionary strata","W-linked gene","sex determining gene","schistosome parasites"],"year":"2021","volume":138,"project":[{"_id":"250ED89C-B435-11E9-9278-68D0E5697425","grant_number":"P28842-B22","name":"Sex chromosome evolution under male- and female- heterogamety","call_identifier":"FWF"}],"isi":1,"corr_author":"1","abstract":[{"lang":"eng","text":"Schistosomes, the human parasites responsible for snail fever, are female-heterogametic. Different parts of their ZW sex chromosomes have stopped recombining in distinct lineages, creating “evolutionary strata” of various ages. Although the Z-chromosome is well characterized at the genomic and molecular level, the W-chromosome has remained largely unstudied from an evolutionary perspective, as only a few W-linked genes have been detected outside of the model species Schistosoma mansoni. Here, we characterize the gene content and evolution of the W-chromosomes of S. mansoni and of the divergent species S. japonicum. We use a combined RNA/DNA k-mer based pipeline to assemble around 100 candidate W-specific transcripts in each of the species. About half of them map to known protein coding genes, the majority homologous to S. mansoni Z-linked genes. We perform an extended analysis of the evolutionary strata present in the two species (including characterizing a previously undetected young stratum in S. japonicum) to infer patterns of sequence and expression evolution of W-linked genes at different time points after recombination was lost. W-linked genes show evidence of degeneration, including high rates of protein evolution and reduced expression. Most are found in young lineage-specific strata, with only a few high expression ancestral W-genes remaining, consistent with the progressive erosion of nonrecombining regions. Among these, the splicing factor u2af2 stands out as a promising candidate for primary sex determination, opening new avenues for understanding the molecular basis of the reproductive biology of this group."}],"file":[{"date_updated":"2022-05-06T09:47:18Z","date_created":"2022-05-06T09:47:18Z","creator":"dernst","success":1,"file_size":1008594,"file_name":"2021_MolecularBiolEvolution_Elkrewi.pdf","checksum":"1b096702fb356d9c0eb88e1b3fcff5f8","file_id":"11352","content_type":"application/pdf","relation":"main_file","access_level":"open_access"}],"_id":"10167","page":"5345-58","status":"public","related_material":{"record":[{"relation":"dissertation_contains","id":"19386","status":"public"}]},"date_updated":"2026-11-12T23:31:03Z","article_processing_charge":"No","department":[{"_id":"BeVi"}],"intvolume":"       138","title":"Schistosome W-linked genes inform temporal dynamics of sex chromosome evolution and suggest candidate for sex determination","publication":"Molecular Biology and Evolution","citation":{"short":"M.N. Elkrewi, M.A. Moldovan, M.A.L. Picard, B. Vicoso, Molecular Biology and Evolution 138 (2021) 5345–58.","chicago":"Elkrewi, Marwan N, Mikhail A. Moldovan, Marion A L Picard, and Beatriz Vicoso. “Schistosome W-Linked Genes Inform Temporal Dynamics of Sex Chromosome Evolution and Suggest Candidate for Sex Determination.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2021. <a href=\"https://doi.org/10.1093/molbev/msab178\">https://doi.org/10.1093/molbev/msab178</a>.","ieee":"M. N. Elkrewi, M. A. Moldovan, M. A. L. Picard, and B. Vicoso, “Schistosome W-linked genes inform temporal dynamics of sex chromosome evolution and suggest candidate for sex determination,” <i>Molecular Biology and Evolution</i>, vol. 138, no. 12. Oxford University Press, pp. 5345–58, 2021.","mla":"Elkrewi, Marwan N., et al. “Schistosome W-Linked Genes Inform Temporal Dynamics of Sex Chromosome Evolution and Suggest Candidate for Sex Determination.” <i>Molecular Biology and Evolution</i>, vol. 138, no. 12, Oxford University Press, 2021, pp. 5345–58, doi:<a href=\"https://doi.org/10.1093/molbev/msab178\">10.1093/molbev/msab178</a>.","apa":"Elkrewi, M. N., Moldovan, M. A., Picard, M. A. L., &#38; Vicoso, B. (2021). Schistosome W-linked genes inform temporal dynamics of sex chromosome evolution and suggest candidate for sex determination. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msab178\">https://doi.org/10.1093/molbev/msab178</a>","ista":"Elkrewi MN, Moldovan MA, Picard MAL, Vicoso B. 2021. Schistosome W-linked genes inform temporal dynamics of sex chromosome evolution and suggest candidate for sex determination. Molecular Biology and Evolution. 138(12), 5345–58.","ama":"Elkrewi MN, Moldovan MA, Picard MAL, Vicoso B. Schistosome W-linked genes inform temporal dynamics of sex chromosome evolution and suggest candidate for sex determination. <i>Molecular Biology and Evolution</i>. 2021;138(12):5345-5358. doi:<a href=\"https://doi.org/10.1093/molbev/msab178\">10.1093/molbev/msab178</a>"},"publication_identifier":{"eissn":["1537-1719"],"issn":["0737-4038"]},"doi":"10.1093/molbev/msab178","issue":"12","quality_controlled":"1","pmid":1,"das_tickbox":"1","fulldoi":"https://doi.org/10.1093/molbev/msab178","day":"19","scopus_import":"1","article_type":"original","date_published":"2021-06-19T00:00:00Z","file_date_updated":"2022-05-06T09:47:18Z","publication_status":"published","month":"06","author":[{"orcid":"0000-0002-5328-7231","first_name":"Marwan N","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","last_name":"Elkrewi","full_name":"Elkrewi, Marwan N"},{"id":"c8bb7f32-3315-11ec-b58b-e5950e6c14a0","last_name":"Moldovan","first_name":"Mikhail A.","orcid":"0000-0002-8876-6494","full_name":"Moldovan, Mikhail A."},{"full_name":"Picard, Marion A L","first_name":"Marion A L","orcid":"0000-0002-8101-2518","id":"2C921A7A-F248-11E8-B48F-1D18A9856A87","last_name":"Picard"},{"full_name":"Vicoso, Beatriz","last_name":"Vicoso","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","orcid":"0000-0002-4579-8306"}],"date_created":"2021-10-21T07:49:12Z","acknowledged_ssus":[{"_id":"ScienComp"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"type":"journal_article"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We are grateful to Akari Hagiwara and Toshihisa Ohtsuka for CAST antibody, and Masahiko Watanabe for neurexin antibody. We thank David Adams for kindly providing the stable Cav2.3 cell line. Cav2.3 KO mice were kindly provided by Tsutomu Tanabe. This project has received funding from the European Research Council (ERC) and European Commission (EC), under the European Union’s Horizon 2020 research and innovation programme (ERC grant agreement no. 694539 to Ryuichi Shigemoto, no. 692692 to Peter Jonas, and the Marie Skłodowska-Curie grant agreement no. 665385 to Cihan Önal), the Swiss National Science Foundation Grant 31003A-172881 to Bernhard Bettler and Deutsche Forschungsgemeinschaft (For 2143) and BIOSS-2 to Akos Kulik.","ddc":["570"],"oa":1,"has_accepted_license":"1","publisher":"eLife Sciences Publications","_id":"9437","date_updated":"2026-11-12T23:31:18Z","related_material":{"link":[{"relation":"earlier_version","url":"https://doi.org/10.1101/2020.04.16.045112"}],"record":[{"relation":"dissertation_contains","id":"9562","status":"public"},{"id":"19271","relation":"dissertation_contains","status":"public"}]},"status":"public","article_processing_charge":"No","department":[{"_id":"RySh"},{"_id":"PeJo"}],"intvolume":"        10","oa_version":"Published Version","language":[{"iso":"eng"}],"external_id":{"pmid":["33913808"],"isi":["000651761700001"]},"volume":10,"year":"2021","project":[{"call_identifier":"H2020","grant_number":"694539","name":"In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour","_id":"25CA28EA-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","grant_number":"692692","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425"},{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","name":"International IST Doctoral Program","call_identifier":"H2020"}],"isi":1,"abstract":[{"lang":"eng","text":"The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+-channel tetramerization domain-containing proteins (KCTDs). Activation of GBRs facilitates or inhibits transmitter release from MHb terminals depending on the IPN subnucleus, but the role of KCTDs is unknown. We therefore examined the localization and function of Cav2.3, GBRs, and KCTDs in this pathway in mice. We show in heterologous cells that KCTD8 and KCTD12b directly bind to Cav2.3 and that KCTD8 potentiates Cav2.3 currents in the absence of GBRs. In the rostral IPN, KCTD8, KCTD12b, and Cav2.3 co-localize at the presynaptic active zone. Genetic deletion indicated a bidirectional modulation of Cav2.3-mediated release by these KCTDs with a compensatory increase of KCTD8 in the active zone in KCTD12b-deficient mice. The interaction of Cav2.3 with KCTDs therefore scales synaptic strength independent of GBR activation."}],"file":[{"content_type":"application/pdf","file_id":"9440","checksum":"6ebcb79999f889766f7cd79ee134ad28","access_level":"open_access","relation":"main_file","creator":"cziletti","date_created":"2021-05-31T09:43:09Z","date_updated":"2021-05-31T09:43:09Z","file_name":"2021_eLife_Bhandari.pdf","file_size":8174719,"success":1}],"quality_controlled":"1","pmid":1,"title":"GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals","publication":"eLife","publication_identifier":{"eissn":["2050-084X"]},"citation":{"ieee":"P. Bhandari <i>et al.</i>, “GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals,” <i>eLife</i>, vol. 10. eLife Sciences Publications, 2021.","apa":"Bhandari, P., Vandael, D. H., Fernández-Fernández, D., Fritzius, T., Kleindienst, D., Önal, C., … Koppensteiner, P. (2021). GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/ELIFE.68274\">https://doi.org/10.7554/ELIFE.68274</a>","ama":"Bhandari P, Vandael DH, Fernández-Fernández D, et al. GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. <i>eLife</i>. 2021;10. doi:<a href=\"https://doi.org/10.7554/ELIFE.68274\">10.7554/ELIFE.68274</a>","ista":"Bhandari P, Vandael DH, Fernández-Fernández D, Fritzius T, Kleindienst D, Önal C, Montanaro-Punzengruber J-C, Gassmann M, Jonas PM, Kulik A, Bettler B, Shigemoto R, Koppensteiner P. 2021. GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. eLife. 10, e68274.","mla":"Bhandari, Pradeep, et al. “GABAB Receptor Auxiliary Subunits Modulate Cav2.3-Mediated Release from Medial Habenula Terminals.” <i>ELife</i>, vol. 10, e68274, eLife Sciences Publications, 2021, doi:<a href=\"https://doi.org/10.7554/ELIFE.68274\">10.7554/ELIFE.68274</a>.","short":"P. Bhandari, D.H. Vandael, D. Fernández-Fernández, T. Fritzius, D. Kleindienst, C. Önal, J.-C. Montanaro-Punzengruber, M. Gassmann, P.M. Jonas, A. Kulik, B. Bettler, R. Shigemoto, P. Koppensteiner, ELife 10 (2021).","chicago":"Bhandari, Pradeep, David H Vandael, Diego Fernández-Fernández, Thorsten Fritzius, David Kleindienst, Cihan Önal, Jacqueline-Claire Montanaro-Punzengruber, et al. “GABAB Receptor Auxiliary Subunits Modulate Cav2.3-Mediated Release from Medial Habenula Terminals.” <i>ELife</i>. eLife Sciences Publications, 2021. <a href=\"https://doi.org/10.7554/ELIFE.68274\">https://doi.org/10.7554/ELIFE.68274</a>."},"doi":"10.7554/ELIFE.68274","article_number":"e68274","month":"04","author":[{"orcid":"0000-0003-0863-4481","first_name":"Pradeep","last_name":"Bhandari","id":"45EDD1BC-F248-11E8-B48F-1D18A9856A87","full_name":"Bhandari, Pradeep"},{"orcid":"0000-0001-7577-1676","first_name":"David H","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87","last_name":"Vandael","full_name":"Vandael, David H"},{"full_name":"Fernández-Fernández, Diego","first_name":"Diego","last_name":"Fernández-Fernández"},{"full_name":"Fritzius, Thorsten","first_name":"Thorsten","last_name":"Fritzius"},{"first_name":"David","last_name":"Kleindienst","id":"42E121A4-F248-11E8-B48F-1D18A9856A87","full_name":"Kleindienst, David"},{"full_name":"Önal, Hüseyin C","last_name":"Önal","id":"4659D740-F248-11E8-B48F-1D18A9856A87","first_name":"Hüseyin C","orcid":"0000-0002-2771-2011"},{"last_name":"Montanaro-Punzengruber","id":"3786AB44-F248-11E8-B48F-1D18A9856A87","first_name":"Jacqueline-Claire","full_name":"Montanaro-Punzengruber, Jacqueline-Claire"},{"first_name":"Martin","last_name":"Gassmann","full_name":"Gassmann, Martin"},{"full_name":"Jonas, Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","first_name":"Peter M"},{"full_name":"Kulik, Akos","first_name":"Akos","last_name":"Kulik"},{"full_name":"Bettler, Bernhard","first_name":"Bernhard","last_name":"Bettler"},{"full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto"},{"full_name":"Koppensteiner, Peter","first_name":"Peter","orcid":"0000-0002-3509-1948","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","last_name":"Koppensteiner"}],"date_created":"2021-05-30T22:01:23Z","type":"journal_article","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"ec_funded":1,"fulldoi":"https://doi.org/10.7554/ELIFE.68274","day":"29","scopus_import":"1","date_published":"2021-04-29T00:00:00Z","publication_status":"published","article_type":"original","file_date_updated":"2021-05-31T09:43:09Z"},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"We thank A. Coll Manzano, F. Freeman, M. Ladron de Guevara, and A. Ç. Yahya for technical assistance, S. Deixler, A. Lepold, and A. Schlerka for the management of our animal colony, as well as M. Schunn and the Preclinical Facility team for technical assistance. We thank K. Heesom and her team at the University of Bristol Proteomics Facility for the proteomics sample preparation, data generation, and analysis support. We thank Y. B. Simon for kindly providing the plasmid for lentiviral labeling. Further, we thank M. Sixt for his advice regarding cell migration and the fruitful discussions. This work was supported by the ISTPlus postdoctoral fellowship (Grant Agreement No. 754411) to B.B., by the European Union’s Horizon 2020 research and innovation program (ERC) grant 715508 (REVERSEAUTISM), and by the Austrian Science Fund (FWF) to G.N. (DK W1232-B24 and SFB F7807-B) and to J.G.D (I3600-B27).","ddc":["572"],"oa":1,"has_accepted_license":"1","publisher":"Springer Nature","_id":"9429","status":"public","related_material":{"record":[{"relation":"earlier_version","id":"7800","status":"public"},{"status":"public","relation":"dissertation_contains","id":"12401"},{"id":"19557","relation":"dissertation_contains","status":"public"}],"link":[{"url":"https://ist.ac.at/en/news/defective-gene-slows-down-brain-cells/","relation":"press_release"}]},"date_updated":"2026-11-13T12:31:10Z","article_processing_charge":"No","department":[{"_id":"GaNo"},{"_id":"JoDa"},{"_id":"FlSc"},{"_id":"MiSi"},{"_id":"LifeSc"},{"_id":"Bio"}],"intvolume":"        12","oa_version":"Published Version","language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology"],"external_id":{"isi":["000658769900010"]},"year":"2021","volume":12,"isi":1,"project":[{"call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"grant_number":"715508","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","_id":"25444568-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"call_identifier":"FWF","_id":"2548AE96-B435-11E9-9278-68D0E5697425","name":"Molecular Drug Targets","grant_number":"W1232"},{"_id":"05A0D778-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P07-Neural stem cells in autism and epilepsy","grant_number":"F7807"},{"grant_number":"I03600","name":"Optical control of synaptic function via adhesion molecules","_id":"265CB4D0-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"corr_author":"1","abstract":[{"lang":"eng","text":"De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 lead to autism spectrum disorder (ASD). In mouse, constitutive haploinsufficiency leads to motor coordination deficits as well as ASD-relevant social and cognitive impairments. However, induction of Cul3 haploinsufficiency later in life does not lead to ASD-relevant behaviors, pointing to an important role of Cul3 during a critical developmental window. Here we show that Cul3 is essential to regulate neuronal migration and, therefore, constitutive Cul3 heterozygous mutant mice display cortical lamination abnormalities. At the molecular level, we found that Cul3 controls neuronal migration by tightly regulating the amount of Plastin3 (Pls3), a previously unrecognized player of neural migration. Furthermore, we found that Pls3 cell-autonomously regulates cell migration by regulating actin cytoskeleton organization, and its levels are inversely proportional to neural migration speed. Finally, we provide evidence that cellular phenotypes associated with autism-linked gene haploinsufficiency can be rescued by transcriptional activation of the intact allele in vitro, offering a proof of concept for a potential therapeutic approach for ASDs."}],"file":[{"success":1,"file_size":9358599,"file_name":"2021_NatureCommunications_Morandell.pdf","creator":"kschuh","date_created":"2021-05-28T12:39:43Z","date_updated":"2021-05-28T12:39:43Z","access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"9430","checksum":"337e0f7959c35ec959984cacdcb472ba"}],"issue":"1","quality_controlled":"1","title":"Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development","publication":"Nature Communications","publication_identifier":{"eissn":["2041-1723"]},"citation":{"ieee":"J. Morandell <i>et al.</i>, “Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021.","mla":"Morandell, Jasmin, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis and Cell Migration during a Critical Window of Brain Development.” <i>Nature Communications</i>, vol. 12, no. 1, 3058, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23123-x\">10.1038/s41467-021-23123-x</a>.","ista":"Morandell J, Schwarz LA, Basilico B, Tasciyan S, Dimchev GA, Nicolas A, Sommer CM, Kreuzinger C, Dotter C, Knaus L, Dobler Z, Cacci E, Schur FK, Danzl JG, Novarino G. 2021. Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. Nature Communications. 12(1), 3058.","ama":"Morandell J, Schwarz LA, Basilico B, et al. Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-23123-x\">10.1038/s41467-021-23123-x</a>","apa":"Morandell, J., Schwarz, L. A., Basilico, B., Tasciyan, S., Dimchev, G. A., Nicolas, A., … Novarino, G. (2021). Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-23123-x\">https://doi.org/10.1038/s41467-021-23123-x</a>","short":"J. Morandell, L.A. Schwarz, B. Basilico, S. Tasciyan, G.A. Dimchev, A. Nicolas, C.M. Sommer, C. Kreuzinger, C. Dotter, L. Knaus, Z. Dobler, E. Cacci, F.K. Schur, J.G. Danzl, G. Novarino, Nature Communications 12 (2021).","chicago":"Morandell, Jasmin, Lena A Schwarz, Bernadette Basilico, Saren Tasciyan, Georgi A Dimchev, Armel Nicolas, Christoph M Sommer, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis and Cell Migration during a Critical Window of Brain Development.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23123-x\">https://doi.org/10.1038/s41467-021-23123-x</a>."},"doi":"10.1038/s41467-021-23123-x","month":"05","article_number":"3058","author":[{"full_name":"Morandell, Jasmin","id":"4739D480-F248-11E8-B48F-1D18A9856A87","last_name":"Morandell","first_name":"Jasmin"},{"first_name":"Lena A","id":"29A8453C-F248-11E8-B48F-1D18A9856A87","last_name":"Schwarz","full_name":"Schwarz, Lena A"},{"first_name":"Bernadette","orcid":"0000-0003-1843-3173","last_name":"Basilico","id":"36035796-5ACA-11E9-A75E-7AF2E5697425","full_name":"Basilico, Bernadette"},{"full_name":"Tasciyan, Saren","first_name":"Saren","orcid":"0000-0003-1671-393X","id":"4323B49C-F248-11E8-B48F-1D18A9856A87","last_name":"Tasciyan"},{"full_name":"Dimchev, Georgi A","first_name":"Georgi A","orcid":"0000-0001-8370-6161","last_name":"Dimchev","id":"38C393BE-F248-11E8-B48F-1D18A9856A87"},{"id":"2A103192-F248-11E8-B48F-1D18A9856A87","last_name":"Nicolas","first_name":"Armel","full_name":"Nicolas, Armel"},{"last_name":"Sommer","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105","first_name":"Christoph M","full_name":"Sommer, Christoph M"},{"full_name":"Kreuzinger, Caroline","last_name":"Kreuzinger","id":"382077BA-F248-11E8-B48F-1D18A9856A87","first_name":"Caroline"},{"full_name":"Dotter, Christoph","orcid":"0000-0002-9033-9096","first_name":"Christoph","id":"4C66542E-F248-11E8-B48F-1D18A9856A87","last_name":"Dotter"},{"full_name":"Knaus, Lisa","last_name":"Knaus","id":"3B2ABCF4-F248-11E8-B48F-1D18A9856A87","first_name":"Lisa"},{"id":"D23090A2-9057-11EA-883A-A8396FC7A38F","last_name":"Dobler","first_name":"Zoe","full_name":"Dobler, Zoe"},{"last_name":"Cacci","first_name":"Emanuele","full_name":"Cacci, Emanuele"},{"full_name":"Schur, Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","last_name":"Schur","orcid":"0000-0003-4790-8078","first_name":"Florian KM"},{"first_name":"Johann G","orcid":"0000-0001-8559-3973","last_name":"Danzl","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","full_name":"Danzl, Johann G"},{"first_name":"Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","full_name":"Novarino, Gaia"}],"date_created":"2021-05-28T11:49:46Z","acknowledged_ssus":[{"_id":"PreCl"}],"type":"journal_article","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"ec_funded":1,"fulldoi":"https://doi.org/10.1038/s41467-021-23123-x","day":"24","scopus_import":"1","publication_status":"published","date_published":"2021-05-24T00:00:00Z","article_type":"original","file_date_updated":"2021-05-28T12:39:43Z"},{"day":"03","fulldoi":"https://doi.org/10.1007/s10009-020-00582-z","article_type":"original","date_published":"2020-08-03T00:00:00Z","publication_status":"published","scopus_import":"1","author":[{"last_name":"Nickovic","id":"41BCEE5C-F248-11E8-B48F-1D18A9856A87","first_name":"Dejan","full_name":"Nickovic, Dejan"},{"full_name":"Lebeltel, Olivier","first_name":"Olivier","last_name":"Lebeltel"},{"last_name":"Maler","first_name":"Oded","full_name":"Maler, Oded"},{"full_name":"Ferrere, Thomas","id":"40960E6E-F248-11E8-B48F-1D18A9856A87","last_name":"Ferrere","first_name":"Thomas","orcid":"0000-0001-5199-3143"},{"last_name":"Ulus","first_name":"Dogan","full_name":"Ulus, Dogan"}],"month":"08","date_created":"2022-03-18T10:10:53Z","type":"journal_article","title":"AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic","publication":"International Journal on Software Tools for Technology Transfer","publication_identifier":{"issn":["1433-2779"],"eissn":["1433-2787"]},"citation":{"chicago":"Nickovic, Dejan, Olivier Lebeltel, Oded Maler, Thomas Ferrere, and Dogan Ulus. “AMT 2.0: Qualitative and Quantitative Trace Analysis with Extended Signal Temporal Logic.” <i>International Journal on Software Tools for Technology Transfer</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s10009-020-00582-z\">https://doi.org/10.1007/s10009-020-00582-z</a>.","short":"D. Nickovic, O. Lebeltel, O. Maler, T. Ferrere, D. Ulus, International Journal on Software Tools for Technology Transfer 22 (2020) 741–758.","mla":"Nickovic, Dejan, et al. “AMT 2.0: Qualitative and Quantitative Trace Analysis with Extended Signal Temporal Logic.” <i>International Journal on Software Tools for Technology Transfer</i>, vol. 22, no. 6, Springer Nature, 2020, pp. 741–58, doi:<a href=\"https://doi.org/10.1007/s10009-020-00582-z\">10.1007/s10009-020-00582-z</a>.","ama":"Nickovic D, Lebeltel O, Maler O, Ferrere T, Ulus D. AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic. <i>International Journal on Software Tools for Technology Transfer</i>. 2020;22(6):741-758. doi:<a href=\"https://doi.org/10.1007/s10009-020-00582-z\">10.1007/s10009-020-00582-z</a>","ista":"Nickovic D, Lebeltel O, Maler O, Ferrere T, Ulus D. 2020. AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic. International Journal on Software Tools for Technology Transfer. 22(6), 741–758.","apa":"Nickovic, D., Lebeltel, O., Maler, O., Ferrere, T., &#38; Ulus, D. (2020). AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic. <i>International Journal on Software Tools for Technology Transfer</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10009-020-00582-z\">https://doi.org/10.1007/s10009-020-00582-z</a>","ieee":"D. Nickovic, O. Lebeltel, O. Maler, T. Ferrere, and D. Ulus, “AMT 2.0: Qualitative and quantitative trace analysis with extended signal temporal logic,” <i>International Journal on Software Tools for Technology Transfer</i>, vol. 22, no. 6. Springer Nature, pp. 741–758, 2020."},"doi":"10.1007/s10009-020-00582-z","issue":"6","quality_controlled":"1","language":[{"iso":"eng"}],"oa_version":"None","volume":22,"year":"2020","keyword":["Information Systems","Software"],"external_id":{"isi":["000555398600001"]},"isi":1,"abstract":[{"lang":"eng","text":"We introduce in this paper AMT2.0, a tool for qualitative and quantitative analysis of hybrid continuous and Boolean signals that combine numerical values and discrete events. The evaluation of the signals is based on rich temporal specifications expressed in extended signal temporal logic, which integrates timed regular expressions within signal temporal logic. The tool features qualitative monitoring (property satisfaction checking), trace diagnostics for explaining and justifying property violations and specification-driven measurement of quantitative features of the signal. We demonstrate the tool functionality on several running examples and case studies, and evaluate its performance."}],"page":"741-758","_id":"10861","article_processing_charge":"No","related_material":{"record":[{"relation":"earlier_version","id":"299","status":"public"}]},"date_updated":"2024-10-09T20:58:18Z","status":"public","department":[{"_id":"ToHe"}],"intvolume":"        22","publisher":"Springer Nature","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"publisher":"Elsevier","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"Partially supported by ERC Advanced Grant RANMAT No. 338804.","oa":1,"isi":1,"project":[{"call_identifier":"FP7","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems","grant_number":"338804"}],"abstract":[{"text":"We consider the sum of two large Hermitian matrices A and B with a Haar unitary conjugation bringing them into a general relative position. We prove that the eigenvalue density on the scale slightly above the local eigenvalue spacing is asymptotically given by the free additive convolution of the laws of A and B as the dimension of the matrix increases. This implies optimal rigidity of the eigenvalues and optimal rate of convergence in Voiculescu's theorem. Our previous works [4], [5] established these results in the bulk spectrum, the current paper completely settles the problem at the spectral edges provided they have the typical square-root behavior. The key element of our proof is to compensate the deterioration of the stability of the subordination equations by sharp error estimates that properly account for the local density near the edge. Our results also hold if the Haar unitary matrix is replaced by the Haar orthogonal matrix.","lang":"eng"}],"corr_author":"1","oa_version":"Preprint","language":[{"iso":"eng"}],"external_id":{"isi":["000559623200009"],"arxiv":["1708.01597"]},"keyword":["Analysis"],"volume":279,"year":"2020","department":[{"_id":"LaEr"}],"intvolume":"       279","_id":"10862","date_updated":"2025-04-15T08:05:01Z","status":"public","article_processing_charge":"No","arxiv":1,"publication_identifier":{"issn":["0022-1236"]},"citation":{"ama":"Bao Z, Erdös L, Schnelli K. Spectral rigidity for addition of random matrices at the regular edge. <i>Journal of Functional Analysis</i>. 2020;279(7). doi:<a href=\"https://doi.org/10.1016/j.jfa.2020.108639\">10.1016/j.jfa.2020.108639</a>","ista":"Bao Z, Erdös L, Schnelli K. 2020. Spectral rigidity for addition of random matrices at the regular edge. Journal of Functional Analysis. 279(7), 108639.","apa":"Bao, Z., Erdös, L., &#38; Schnelli, K. (2020). Spectral rigidity for addition of random matrices at the regular edge. <i>Journal of Functional Analysis</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jfa.2020.108639\">https://doi.org/10.1016/j.jfa.2020.108639</a>","mla":"Bao, Zhigang, et al. “Spectral Rigidity for Addition of Random Matrices at the Regular Edge.” <i>Journal of Functional Analysis</i>, vol. 279, no. 7, 108639, Elsevier, 2020, doi:<a href=\"https://doi.org/10.1016/j.jfa.2020.108639\">10.1016/j.jfa.2020.108639</a>.","ieee":"Z. Bao, L. Erdös, and K. Schnelli, “Spectral rigidity for addition of random matrices at the regular edge,” <i>Journal of Functional Analysis</i>, vol. 279, no. 7. Elsevier, 2020.","chicago":"Bao, Zhigang, László Erdös, and Kevin Schnelli. “Spectral Rigidity for Addition of Random Matrices at the Regular Edge.” <i>Journal of Functional Analysis</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.jfa.2020.108639\">https://doi.org/10.1016/j.jfa.2020.108639</a>.","short":"Z. Bao, L. Erdös, K. Schnelli, Journal of Functional Analysis 279 (2020)."},"doi":"10.1016/j.jfa.2020.108639","title":"Spectral rigidity for addition of random matrices at the regular edge","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1708.01597"}],"publication":"Journal of Functional Analysis","issue":"7","quality_controlled":"1","fulldoi":"https://doi.org/10.1016/j.jfa.2020.108639","day":"15","scopus_import":"1","date_published":"2020-10-15T00:00:00Z","article_type":"original","publication_status":"published","type":"journal_article","ec_funded":1,"month":"10","article_number":"108639","author":[{"full_name":"Bao, Zhigang","id":"442E6A6C-F248-11E8-B48F-1D18A9856A87","last_name":"Bao","first_name":"Zhigang","orcid":"0000-0003-3036-1475"},{"full_name":"Erdös, László","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603"},{"full_name":"Schnelli, Kevin","last_name":"Schnelli","first_name":"Kevin"}],"date_created":"2022-03-18T10:18:59Z"},{"intvolume":"     12110","article_processing_charge":"No","date_updated":"2026-04-16T10:21:31Z","status":"public","page":"220-246","_id":"10865","abstract":[{"lang":"eng","text":"We introduce the notion of Witness Maps as a cryptographic notion of a proof system. A Unique Witness Map (UWM) deterministically maps all witnesses for an   NP  statement to a single representative witness, resulting in a computationally sound, deterministic-prover, non-interactive witness independent proof system. A relaxation of UWM, called Compact Witness Map (CWM), maps all the witnesses to a small number of witnesses, resulting in a “lossy” deterministic-prover, non-interactive proof-system. We also define a Dual Mode Witness Map (DMWM) which adds an “extractable” mode to a CWM.\r\nOur main construction is a DMWM for all   NP  relations, assuming sub-exponentially secure indistinguishability obfuscation (  iO ), along with standard cryptographic assumptions. The DMWM construction relies on a CWM and a new primitive called Cumulative All-Lossy-But-One Trapdoor Functions (C-ALBO-TDF), both of which are in turn instantiated based on   iO  and other primitives. Our instantiation of a CWM is in fact a UWM; in turn, we show that a UWM implies Witness Encryption. Along the way to constructing UWM and C-ALBO-TDF, we also construct, from standard assumptions, Puncturable Digital Signatures and a new primitive called Cumulative Lossy Trapdoor Functions (C-LTDF). The former improves up on a construction of Bellare et al. (Eurocrypt 2016), who relied on sub-exponentially secure   iO  and sub-exponentially secure OWF.\r\nAs an application of our constructions, we show how to use a DMWM to construct the first leakage and tamper-resilient signatures with a deterministic signer, thereby solving a decade old open problem posed by Katz and Vaikunthanathan (Asiacrypt 2009), by Boyle, Segev and Wichs (Eurocrypt 2011), as well as by Faonio and Venturi (Asiacrypt 2016). Our construction achieves the optimal leakage rate of   1−o(1) ."}],"corr_author":"1","isi":1,"volume":12110,"year":"2020","external_id":{"isi":["001299210200008"]},"language":[{"iso":"eng"}],"oa_version":"Preprint","editor":[{"last_name":"Kiayias","first_name":"A","full_name":"Kiayias, A"}],"oa":1,"acknowledgement":"We would like to thank the anonymous reviewers of PKC 2019 for their useful comments and suggestions. We thank Omer Paneth for pointing out to us the connection between Unique Witness Maps (UWM) and Witness encryption (WE). The first author would like to acknowledge Pandu Rangan for his involvement during the initial discussion phase of the project.","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","series_title":"LNCS","place":"Cham","publisher":"Springer Nature","type":"book_chapter","date_created":"2022-03-18T11:35:51Z","author":[{"full_name":"Chakraborty, Suvradip","id":"B9CD0494-D033-11E9-B219-A439E6697425","last_name":"Chakraborty","first_name":"Suvradip"},{"full_name":"Prabhakaran, Manoj","last_name":"Prabhakaran","first_name":"Manoj"},{"full_name":"Wichs, Daniel","last_name":"Wichs","first_name":"Daniel"}],"month":"04","date_published":"2020-04-29T00:00:00Z","publication_status":"published","scopus_import":"1","day":"29","fulldoi":"https://doi.org/10.1007/978-3-030-45374-9_8","quality_controlled":"1","doi":"10.1007/978-3-030-45374-9_8","publication_identifier":{"issn":["0302-9743"],"eisbn":["9783030453749"],"eissn":["1611-3349"],"isbn":["9783030453732"]},"citation":{"ieee":"S. Chakraborty, M. Prabhakaran, and D. Wichs, “Witness maps and applications,” in <i>Public-Key Cryptography</i>, vol. 12110, A. Kiayias, Ed. Cham: Springer Nature, 2020, pp. 220–246.","mla":"Chakraborty, Suvradip, et al. “Witness Maps and Applications.” <i>Public-Key Cryptography</i>, edited by A Kiayias, vol. 12110, Springer Nature, 2020, pp. 220–46, doi:<a href=\"https://doi.org/10.1007/978-3-030-45374-9_8\">10.1007/978-3-030-45374-9_8</a>.","ista":"Chakraborty S, Prabhakaran M, Wichs D. 2020.Witness maps and applications. In: Public-Key Cryptography. vol. 12110, 220–246.","apa":"Chakraborty, S., Prabhakaran, M., &#38; Wichs, D. (2020). Witness maps and applications. In A. Kiayias (Ed.), <i>Public-Key Cryptography</i> (Vol. 12110, pp. 220–246). Cham: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-45374-9_8\">https://doi.org/10.1007/978-3-030-45374-9_8</a>","ama":"Chakraborty S, Prabhakaran M, Wichs D. Witness maps and applications. In: Kiayias A, ed. <i>Public-Key Cryptography</i>. Vol 12110. LNCS. Cham: Springer Nature; 2020:220-246. doi:<a href=\"https://doi.org/10.1007/978-3-030-45374-9_8\">10.1007/978-3-030-45374-9_8</a>","short":"S. Chakraborty, M. Prabhakaran, D. Wichs, in:, A. Kiayias (Ed.), Public-Key Cryptography, Springer Nature, Cham, 2020, pp. 220–246.","chicago":"Chakraborty, Suvradip, Manoj Prabhakaran, and Daniel Wichs. “Witness Maps and Applications.” In <i>Public-Key Cryptography</i>, edited by A Kiayias, 12110:220–46. LNCS. Cham: Springer Nature, 2020. <a href=\"https://doi.org/10.1007/978-3-030-45374-9_8\">https://doi.org/10.1007/978-3-030-45374-9_8</a>."},"publication":"Public-Key Cryptography","main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2020/090"}],"title":"Witness maps and applications"},{"day":"01","fulldoi":"https://doi.org/10.1021/acs.nanolett.0c01673","date_published":"2020-07-01T00:00:00Z","publication_status":"published","article_type":"original","scopus_import":"1","type":"journal_article","author":[{"first_name":"Jiahua","last_name":"Duan","full_name":"Duan, Jiahua"},{"full_name":"Capote-Robayna, Nathaniel","first_name":"Nathaniel","last_name":"Capote-Robayna"},{"full_name":"Taboada-Gutiérrez, Javier","first_name":"Javier","last_name":"Taboada-Gutiérrez"},{"last_name":"Álvarez-Pérez","first_name":"Gonzalo","full_name":"Álvarez-Pérez, Gonzalo"},{"full_name":"Prieto Gonzalez, Ivan","first_name":"Ivan","orcid":"0000-0002-7370-5357","id":"2A307FE2-F248-11E8-B48F-1D18A9856A87","last_name":"Prieto Gonzalez"},{"full_name":"Martín-Sánchez, Javier","first_name":"Javier","last_name":"Martín-Sánchez"},{"full_name":"Nikitin, Alexey Y.","last_name":"Nikitin","first_name":"Alexey Y."},{"last_name":"Alonso-González","first_name":"Pablo","full_name":"Alonso-González, Pablo"}],"month":"07","date_created":"2022-03-18T11:37:38Z","publication_identifier":{"eissn":["1530-6992"],"issn":["1530-6984"]},"citation":{"short":"J. Duan, N. Capote-Robayna, J. Taboada-Gutiérrez, G. Álvarez-Pérez, I. Prieto Gonzalez, J. Martín-Sánchez, A.Y. Nikitin, P. Alonso-González, Nano Letters 20 (2020) 5323–5329.","chicago":"Duan, Jiahua, Nathaniel Capote-Robayna, Javier Taboada-Gutiérrez, Gonzalo Álvarez-Pérez, Ivan Prieto Gonzalez, Javier Martín-Sánchez, Alexey Y. Nikitin, and Pablo Alonso-González. “Twisted Nano-Optics: Manipulating Light at the Nanoscale with Twisted Phonon Polaritonic Slabs.” <i>Nano Letters</i>. American Chemical Society, 2020. <a href=\"https://doi.org/10.1021/acs.nanolett.0c01673\">https://doi.org/10.1021/acs.nanolett.0c01673</a>.","ieee":"J. Duan <i>et al.</i>, “Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs,” <i>Nano Letters</i>, vol. 20, no. 7. American Chemical Society, pp. 5323–5329, 2020.","ama":"Duan J, Capote-Robayna N, Taboada-Gutiérrez J, et al. Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs. <i>Nano Letters</i>. 2020;20(7):5323-5329. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.0c01673\">10.1021/acs.nanolett.0c01673</a>","apa":"Duan, J., Capote-Robayna, N., Taboada-Gutiérrez, J., Álvarez-Pérez, G., Prieto Gonzalez, I., Martín-Sánchez, J., … Alonso-González, P. (2020). Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.0c01673\">https://doi.org/10.1021/acs.nanolett.0c01673</a>","ista":"Duan J, Capote-Robayna N, Taboada-Gutiérrez J, Álvarez-Pérez G, Prieto Gonzalez I, Martín-Sánchez J, Nikitin AY, Alonso-González P. 2020. Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs. Nano Letters. 20(7), 5323–5329.","mla":"Duan, Jiahua, et al. “Twisted Nano-Optics: Manipulating Light at the Nanoscale with Twisted Phonon Polaritonic Slabs.” <i>Nano Letters</i>, vol. 20, no. 7, American Chemical Society, 2020, pp. 5323–29, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.0c01673\">10.1021/acs.nanolett.0c01673</a>."},"arxiv":1,"doi":"10.1021/acs.nanolett.0c01673","main_file_link":[{"url":"https://arxiv.org/abs/2004.14599","open_access":"1"}],"title":"Twisted nano-optics: Manipulating light at the nanoscale with twisted phonon polaritonic slabs","publication":"Nano Letters","issue":"7","pmid":1,"quality_controlled":"1","isi":1,"abstract":[{"text":"Recent discoveries have shown that, when two layers of van der Waals (vdW) materials are superimposed with a relative twist angle between them, the electronic properties of the coupled system can be dramatically altered. Here, we demonstrate that a similar concept can be extended to the optics realm, particularly to propagating phonon polaritons–hybrid light-matter interactions. To do this, we fabricate stacks composed of two twisted slabs of a vdW crystal (α-MoO3) supporting anisotropic phonon polaritons (PhPs), and image the propagation of the latter when launched by localized sources. Our images reveal that, under a critical angle, the PhPs isofrequency curve undergoes a topological transition, in which the propagation of PhPs is strongly guided (canalization regime) along predetermined directions without geometric spreading. These results demonstrate a new degree of freedom (twist angle) for controlling the propagation of polaritons at the nanoscale with potential for nanoimaging, (bio)-sensing, or heat management.","lang":"eng"}],"language":[{"iso":"eng"}],"oa_version":"Preprint","volume":20,"year":"2020","keyword":["Mechanical Engineering","Condensed Matter Physics","General Materials Science","General Chemistry","Bioengineering"],"external_id":{"isi":["000548893200082"],"arxiv":["2004.14599"],"pmid":["32530634"]},"department":[{"_id":"NanoFab"}],"intvolume":"        20","page":"5323-5329","_id":"10866","article_processing_charge":"No","date_updated":"2023-09-05T12:05:58Z","status":"public","publisher":"American Chemical Society","acknowledgement":"J.T.-G. and G.Á.-P. acknowledge support through the Severo Ochoa Program from the\r\nGovernment of the Principality of Asturias (nos. PA-18-PF-BP17-126 and PA20-PF-BP19-053,\r\nrespectively). J. M-S acknowledges financial support through the Ramón y Cajal Program from\r\nthe Government of Spain (RYC2018-026196-I). A.Y.N. acknowledges the Spanish Ministry of\r\nScience, Innovation and Universities (national project no. MAT201788358-C3-3-R). P.A.-G.\r\nacknowledges support from the European Research Council under starting grant no. 715496,\r\n2DNANOPTICA.","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1},{"type":"journal_article","author":[{"full_name":"Akopyan, Arseniy","orcid":"0000-0002-2548-617X","first_name":"Arseniy","last_name":"Akopyan","id":"430D2C90-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Roman","last_name":"Karasev","full_name":"Karasev, Roman"}],"month":"02","date_created":"2022-03-18T11:39:30Z","day":"01","fulldoi":"https://doi.org/10.1093/imrn/rny037","article_type":"original","publication_status":"published","date_published":"2020-02-01T00:00:00Z","scopus_import":"1","issue":"3","quality_controlled":"1","citation":{"chicago":"Akopyan, Arseniy, and Roman Karasev. “Waist of Balls in Hyperbolic and Spherical Spaces.” <i>International Mathematics Research Notices</i>. Oxford University Press, 2020. <a href=\"https://doi.org/10.1093/imrn/rny037\">https://doi.org/10.1093/imrn/rny037</a>.","short":"A. Akopyan, R. Karasev, International Mathematics Research Notices 2020 (2020) 669–697.","apa":"Akopyan, A., &#38; Karasev, R. (2020). Waist of balls in hyperbolic and spherical spaces. <i>International Mathematics Research Notices</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/imrn/rny037\">https://doi.org/10.1093/imrn/rny037</a>","ama":"Akopyan A, Karasev R. Waist of balls in hyperbolic and spherical spaces. <i>International Mathematics Research Notices</i>. 2020;2020(3):669-697. doi:<a href=\"https://doi.org/10.1093/imrn/rny037\">10.1093/imrn/rny037</a>","ista":"Akopyan A, Karasev R. 2020. Waist of balls in hyperbolic and spherical spaces. International Mathematics Research Notices. 2020(3), 669–697.","mla":"Akopyan, Arseniy, and Roman Karasev. “Waist of Balls in Hyperbolic and Spherical Spaces.” <i>International Mathematics Research Notices</i>, vol. 2020, no. 3, Oxford University Press, 2020, pp. 669–97, doi:<a href=\"https://doi.org/10.1093/imrn/rny037\">10.1093/imrn/rny037</a>.","ieee":"A. Akopyan and R. Karasev, “Waist of balls in hyperbolic and spherical spaces,” <i>International Mathematics Research Notices</i>, vol. 2020, no. 3. Oxford University Press, pp. 669–697, 2020."},"publication_identifier":{"issn":["1073-7928"],"eissn":["1687-0247"]},"arxiv":1,"doi":"10.1093/imrn/rny037","title":"Waist of balls in hyperbolic and spherical spaces","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1702.07513"}],"publication":"International Mathematics Research Notices","department":[{"_id":"HeEd"}],"intvolume":"      2020","page":"669-697","_id":"10867","article_processing_charge":"No","status":"public","date_updated":"2023-08-24T14:19:55Z","isi":1,"abstract":[{"text":"In this paper we find a tight estimate for Gromov’s waist of the balls in spaces of constant curvature, deduce the estimates for the balls in Riemannian manifolds with upper bounds on the curvature (CAT(ϰ)-spaces), and establish similar result for normed spaces.","lang":"eng"}],"language":[{"iso":"eng"}],"oa_version":"Preprint","year":"2020","volume":2020,"keyword":["General Mathematics"],"external_id":{"arxiv":["1702.07513"],"isi":["000522852700002"]},"acknowledgement":" Supported by the Russian Foundation for Basic Research grant 18-01-00036.","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"publisher":"Oxford University Press"},{"issue":"6","extern":"1","pmid":1,"quality_controlled":"1","citation":{"chicago":"Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging.” <i>Neuron</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.neuron.2020.05.031\">https://doi.org/10.1016/j.neuron.2020.05.031</a>.","short":"U.H. Cho, M. Hetzer, Neuron 106 (2020) 899–911.","mla":"Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging.” <i>Neuron</i>, vol. 106, no. 6, Elsevier, 2020, pp. 899–911, doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.05.031\">10.1016/j.neuron.2020.05.031</a>.","ista":"Cho UH, Hetzer M. 2020. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. 106(6), 899–911.","ama":"Cho UH, Hetzer M. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. <i>Neuron</i>. 2020;106(6):899-911. doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.05.031\">10.1016/j.neuron.2020.05.031</a>","apa":"Cho, U. H., &#38; Hetzer, M. (2020). Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2020.05.031\">https://doi.org/10.1016/j.neuron.2020.05.031</a>","ieee":"U. H. Cho and M. Hetzer, “Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging,” <i>Neuron</i>, vol. 106, no. 6. Elsevier, pp. 899–911, 2020."},"publication_identifier":{"issn":["0896-6273"]},"doi":"10.1016/j.neuron.2020.05.031","title":"Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging","main_file_link":[{"url":"https://doi.org/10.1016/j.neuron.2020.05.031","open_access":"1"}],"publication":"Neuron","type":"journal_article","author":[{"full_name":"Cho, Ukrae H.","first_name":"Ukrae H.","last_name":"Cho"},{"full_name":"HETZER, Martin W","first_name":"Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"month":"06","date_created":"2022-04-07T07:43:36Z","day":"17","fulldoi":"https://doi.org/10.1016/j.neuron.2020.05.031","publication_status":"published","date_published":"2020-06-17T00:00:00Z","article_type":"review","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"publisher":"Elsevier","intvolume":"       106","page":"899-911","_id":"11054","article_processing_charge":"No","status":"public","date_updated":"2024-10-14T11:15:26Z","abstract":[{"lang":"eng","text":"In recent years, the nuclear pore complex (NPC) has emerged as a key player in genome regulation and cellular homeostasis. New discoveries have revealed that the NPC has multiple cellular functions besides mediating the molecular exchange between the nucleus and the cytoplasm. In this review, we discuss non-transport aspects of the NPC focusing on the NPC-genome interaction, the extreme longevity of the NPC proteins, and NPC dysfunction in age-related diseases. The examples summarized herein demonstrate that the NPC, which first evolved to enable the biochemical communication between the nucleus and the cytoplasm, now doubles as the gatekeeper of cellular identity and aging."}],"language":[{"iso":"eng"}],"oa_version":"Published Version","volume":106,"year":"2020","keyword":["General Neuroscience"],"external_id":{"pmid":["32553207"]}},{"intvolume":"         9","article_processing_charge":"No","status":"public","date_updated":"2024-10-14T11:17:02Z","_id":"11055","file":[{"success":1,"file_size":4399825,"file_name":"2020_eLife_Bersini.pdf","creator":"dernst","date_created":"2022-04-08T06:53:10Z","date_updated":"2022-04-08T06:53:10Z","access_level":"open_access","relation":"main_file","file_id":"11132","content_type":"application/pdf","checksum":"f8b3821349a194050be02570d8fe7d4b"}],"abstract":[{"text":"Vascular dysfunctions are a common feature of multiple age-related diseases. However, modeling healthy and pathological aging of the human vasculature represents an unresolved experimental challenge. Here, we generated induced vascular endothelial cells (iVECs) and smooth muscle cells (iSMCs) by direct reprogramming of healthy human fibroblasts from donors of different ages and Hutchinson-Gilford Progeria Syndrome (HGPS) patients. iVECs induced from old donors revealed upregulation of GSTM1 and PALD1, genes linked to oxidative stress, inflammation and endothelial junction stability, as vascular aging markers. A functional assay performed on PALD1 KD VECs demonstrated a recovery in vascular permeability. We found that iSMCs from HGPS donors overexpressed bone morphogenetic protein (BMP)−4, which plays a key role in both vascular calcification and endothelial barrier damage observed in HGPS. Strikingly, BMP4 concentrations are higher in serum from HGPS vs. age-matched mice. Furthermore, targeting BMP4 with blocking antibody recovered the functionality of the vascular barrier in vitro, hence representing a potential future therapeutic strategy to limit cardiovascular dysfunction in HGPS. These results show that iVECs and iSMCs retain disease-related signatures, allowing modeling of vascular aging and HGPS in vitro.","lang":"eng"}],"volume":9,"year":"2020","external_id":{"pmid":["32896271"]},"keyword":["General Immunology and Microbiology","General Biochemistry","Genetics and Molecular Biology","General Medicine","General Neuroscience"],"language":[{"iso":"eng"}],"oa_version":"Published Version","ddc":["570"],"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"eLife Sciences Publications","has_accepted_license":"1","type":"journal_article","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"date_created":"2022-04-07T07:43:48Z","author":[{"full_name":"Bersini, Simone","last_name":"Bersini","first_name":"Simone"},{"last_name":"Schulte","first_name":"Roberta","full_name":"Schulte, Roberta"},{"full_name":"Huang, Ling","last_name":"Huang","first_name":"Ling"},{"last_name":"Tsai","first_name":"Hannah","full_name":"Tsai, Hannah"},{"full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","first_name":"Martin W","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"month":"09","article_number":"e54383","publication_status":"published","article_type":"original","file_date_updated":"2022-04-08T06:53:10Z","date_published":"2020-09-08T00:00:00Z","scopus_import":"1","day":"08","fulldoi":"https://doi.org/10.7554/elife.54383","pmid":1,"quality_controlled":"1","extern":"1","doi":"10.7554/elife.54383","citation":{"short":"S. Bersini, R. Schulte, L. Huang, H. Tsai, M. Hetzer, ELife 9 (2020).","chicago":"Bersini, Simone, Roberta Schulte, Ling Huang, Hannah Tsai, and Martin Hetzer. “Direct Reprogramming of Human Smooth Muscle and Vascular Endothelial Cells Reveals Defects Associated with Aging and Hutchinson-Gilford Progeria Syndrome.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/elife.54383\">https://doi.org/10.7554/elife.54383</a>.","ieee":"S. Bersini, R. Schulte, L. Huang, H. Tsai, and M. Hetzer, “Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020.","mla":"Bersini, Simone, et al. “Direct Reprogramming of Human Smooth Muscle and Vascular Endothelial Cells Reveals Defects Associated with Aging and Hutchinson-Gilford Progeria Syndrome.” <i>ELife</i>, vol. 9, e54383, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/elife.54383\">10.7554/elife.54383</a>.","ista":"Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. 2020. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. eLife. 9, e54383.","apa":"Bersini, S., Schulte, R., Huang, L., Tsai, H., &#38; Hetzer, M. (2020). Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/elife.54383\">https://doi.org/10.7554/elife.54383</a>","ama":"Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/elife.54383\">10.7554/elife.54383</a>"},"publication_identifier":{"issn":["2050-084X"]},"publication":"eLife","title":"Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome"},{"doi":"10.1002/adbi.202000044","publication_identifier":{"issn":["2366-7478","2366-7478"]},"citation":{"short":"S. Bersini, R. Arrojo e Drigo, L. Huang, M.N. Shokhirev, M. Hetzer, Advanced Biosystems 4 (2020).","chicago":"Bersini, Simone, Rafael Arrojo e Drigo, Ling Huang, Maxim N. Shokhirev, and Martin Hetzer. “Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.” <i>Advanced Biosystems</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/adbi.202000044\">https://doi.org/10.1002/adbi.202000044</a>.","ieee":"S. Bersini, R. Arrojo e Drigo, L. Huang, M. N. Shokhirev, and M. Hetzer, “Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease,” <i>Advanced Biosystems</i>, vol. 4, no. 5. Wiley, 2020.","mla":"Bersini, Simone, et al. “Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.” <i>Advanced Biosystems</i>, vol. 4, no. 5, 2000044, Wiley, 2020, doi:<a href=\"https://doi.org/10.1002/adbi.202000044\">10.1002/adbi.202000044</a>.","ista":"Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. 2020. Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. Advanced Biosystems. 4(5), 2000044.","ama":"Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. <i>Advanced Biosystems</i>. 2020;4(5). doi:<a href=\"https://doi.org/10.1002/adbi.202000044\">10.1002/adbi.202000044</a>","apa":"Bersini, S., Arrojo e Drigo, R., Huang, L., Shokhirev, M. N., &#38; Hetzer, M. (2020). Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. <i>Advanced Biosystems</i>. Wiley. <a href=\"https://doi.org/10.1002/adbi.202000044\">https://doi.org/10.1002/adbi.202000044</a>"},"publication":"Advanced Biosystems","title":"Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease","quality_controlled":"1","pmid":1,"extern":"1","issue":"5","scopus_import":"1","article_type":"original","publication_status":"published","file_date_updated":"2022-04-08T07:06:05Z","date_published":"2020-05-01T00:00:00Z","fulldoi":"https://doi.org/10.1002/adbi.202000044","day":"01","type":"journal_article","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"date_created":"2022-04-07T07:43:57Z","month":"05","article_number":"2000044","author":[{"full_name":"Bersini, Simone","first_name":"Simone","last_name":"Bersini"},{"full_name":"Arrojo e Drigo, Rafael","last_name":"Arrojo e Drigo","first_name":"Rafael"},{"last_name":"Huang","first_name":"Ling","full_name":"Huang, Ling"},{"full_name":"Shokhirev, Maxim N.","last_name":"Shokhirev","first_name":"Maxim N."},{"full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","first_name":"Martin W","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"publisher":"Wiley","has_accepted_license":"1","ddc":["570"],"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Aging of the circulatory system correlates with the pathogenesis of a large spectrum of diseases. However, it is largely unknown which factors drive the age-dependent or pathological decline of the vasculature and how vascular defects relate to tissue aging. The goal of the study is to design a multianalytical approach to identify how the cellular microenvironment (i.e., fibroblasts) and serum from healthy donors of different ages or Alzheimer disease (AD) patients can modulate the functionality of organ-specific vascular endothelial cells (VECs). Long-living human microvascular networks embedding VECs and fibroblasts from skin biopsies are generated. RNA-seq, secretome analyses, and microfluidic assays demonstrate that fibroblasts from young donors restore the functionality of aged endothelial cells, an effect also achieved by serum from young donors. New biomarkers of vascular aging are validated in human biopsies and it is shown that young serum induces angiopoietin-like-4, which can restore compromised vascular barriers. This strategy is then employed to characterize transcriptional/functional changes induced on the blood–brain barrier by AD serum, demonstrating the importance of PTP4A3 in the regulation of permeability. Features of vascular degeneration during aging and AD are recapitulated, and a tool to identify novel biomarkers that can be exploited to develop future therapeutics modulating vascular function is established.","lang":"eng"}],"file":[{"checksum":"5584d9a1609812dc75c02ce1e35d2ec0","content_type":"application/pdf","file_id":"11134","relation":"main_file","access_level":"open_access","date_created":"2022-04-08T07:06:05Z","date_updated":"2022-04-08T07:06:05Z","creator":"dernst","file_name":"2020_AdvancedBiosystems_Bersini.pdf","file_size":2490829,"success":1}],"external_id":{"pmid":["32402127"]},"keyword":["General Biochemistry","Genetics and Molecular Biology","Biomedical Engineering","Biomaterials"],"volume":4,"year":"2020","oa_version":"Published Version","language":[{"iso":"eng"}],"intvolume":"         4","status":"public","date_updated":"2024-10-14T11:18:07Z","article_processing_charge":"No","_id":"11056"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"ddc":["570"],"publisher":"Cold Spring Harbor Laboratory Press","has_accepted_license":"1","page":"913-930","_id":"11057","article_processing_charge":"No","status":"public","date_updated":"2024-10-14T11:18:25Z","intvolume":"        34","language":[{"iso":"eng"}],"oa_version":"Published Version","volume":34,"year":"2020","keyword":["Developmental Biology","Genetics"],"external_id":{"pmid":["32499403"]},"file":[{"file_size":4406772,"success":1,"file_name":"2020_GenesDevelopment_Kang.pdf","date_updated":"2022-04-08T07:12:33Z","date_created":"2022-04-08T07:12:33Z","creator":"dernst","relation":"main_file","access_level":"open_access","checksum":"84e92d40e67936c739628315c238daf9","content_type":"application/pdf","file_id":"11136"}],"abstract":[{"lang":"eng","text":"During mitosis, transcription of genomic DNA is dramatically reduced, before it is reactivated during nuclear reformation in anaphase/telophase. Many aspects of the underlying principles that mediate transcriptional memory and reactivation in the daughter cells remain unclear. Here, we used ChIP-seq on synchronized cells at different stages after mitosis to generate genome-wide maps of histone modifications. Combined with EU-RNA-seq and Hi-C analyses, we found that during prometaphase, promoters, enhancers, and insulators retain H3K4me3 and H3K4me1, while losing H3K27ac. Enhancers globally retaining mitotic H3K4me1 or locally retaining mitotic H3K27ac are associated with cell type-specific genes and their transcription factors for rapid transcriptional activation. As cells exit mitosis, promoters regain H3K27ac, which correlates with transcriptional reactivation. Insulators also gain H3K27ac and CCCTC-binding factor (CTCF) in anaphase/telophase. This increase of H3K27ac in anaphase/telophase is required for posttranscriptional activation and may play a role in the establishment of topologically associating domains (TADs). Together, our results suggest that the genome is reorganized in a sequential order, in which histone methylations occur first in prometaphase, histone acetylation, and CTCF in anaphase/telophase, transcription in cytokinesis, and long-range chromatin interactions in early G1. We thus provide insights into the histone modification landscape that allows faithful reestablishment of the transcriptional program and TADs during cell division."}],"issue":"13-14","extern":"1","pmid":1,"quality_controlled":"1","title":"Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation","publication":"Genes & Development","citation":{"ista":"Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. 2020. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Genes &#38; Development. 34(13–14), 913–930.","ama":"Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. <i>Genes &#38; Development</i>. 2020;34(13-14):913-930. doi:<a href=\"https://doi.org/10.1101/gad.335794.119\">10.1101/gad.335794.119</a>","apa":"Kang, H., Shokhirev, M. N., Xu, Z., Chandran, S., Dixon, J. R., &#38; Hetzer, M. (2020). Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/gad.335794.119\">https://doi.org/10.1101/gad.335794.119</a>","mla":"Kang, Hyeseon, et al. “Dynamic Regulation of Histone Modifications and Long-Range Chromosomal Interactions during Postmitotic Transcriptional Reactivation.” <i>Genes &#38; Development</i>, vol. 34, no. 13–14, Cold Spring Harbor Laboratory Press, 2020, pp. 913–30, doi:<a href=\"https://doi.org/10.1101/gad.335794.119\">10.1101/gad.335794.119</a>.","ieee":"H. Kang, M. N. Shokhirev, Z. Xu, S. Chandran, J. R. Dixon, and M. Hetzer, “Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation,” <i>Genes &#38; Development</i>, vol. 34, no. 13–14. Cold Spring Harbor Laboratory Press, pp. 913–930, 2020.","chicago":"Kang, Hyeseon, Maxim N. Shokhirev, Zhichao Xu, Sahaana Chandran, Jesse R. Dixon, and Martin Hetzer. “Dynamic Regulation of Histone Modifications and Long-Range Chromosomal Interactions during Postmitotic Transcriptional Reactivation.” <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory Press, 2020. <a href=\"https://doi.org/10.1101/gad.335794.119\">https://doi.org/10.1101/gad.335794.119</a>.","short":"H. Kang, M.N. Shokhirev, Z. Xu, S. Chandran, J.R. Dixon, M. Hetzer, Genes &#38; Development 34 (2020) 913–930."},"publication_identifier":{"issn":["0890-9369","1549-5477"]},"doi":"10.1101/gad.335794.119","author":[{"full_name":"Kang, Hyeseon","last_name":"Kang","first_name":"Hyeseon"},{"last_name":"Shokhirev","first_name":"Maxim N.","full_name":"Shokhirev, Maxim N."},{"last_name":"Xu","first_name":"Zhichao","full_name":"Xu, Zhichao"},{"full_name":"Chandran, Sahaana","last_name":"Chandran","first_name":"Sahaana"},{"first_name":"Jesse R.","last_name":"Dixon","full_name":"Dixon, Jesse R."},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","first_name":"Martin W","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W"}],"month":"04","date_created":"2022-04-07T07:44:09Z","type":"journal_article","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"day":"28","fulldoi":"https://doi.org/10.1101/gad.335794.119","file_date_updated":"2022-04-08T07:12:33Z","publication_status":"published","article_type":"original","date_published":"2020-04-28T00:00:00Z","scopus_import":"1"},{"abstract":[{"text":"Nucleoporin 93 (Nup93) expression inversely correlates with the survival of triple-negative breast cancer patients. However, our knowledge of Nup93 function in breast cancer besides its role as structural component of the nuclear pore complex is not understood. Combination of functional assays and genetic analyses suggested that chromatin interaction of Nup93 partially modulates the expression of genes associated with actin cytoskeleton remodeling and epithelial to mesenchymal transition, resulting in impaired invasion of triple-negative, claudin-low breast cancer cells. Nup93 depletion induced stress fiber formation associated with reduced cell migration/proliferation and impaired expression of mesenchymal-like genes. Silencing LIMCH1, a gene responsible for actin cytoskeleton remodeling and up-regulated upon Nup93 depletion, partially restored the invasive phenotype of cancer cells. Loss of Nup93 led to significant defects in tumor establishment/propagation in vivo, whereas patient samples revealed that high Nup93 and low LIMCH1 expression correlate with late tumor stage. Our approach identified Nup93 as contributor of triple-negative, claudin-low breast cancer cell invasion and paves the way to study the role of nuclear envelope proteins during breast cancer tumorigenesis.","lang":"eng"}],"file":[{"creator":"dernst","date_created":"2022-04-08T07:33:01Z","date_updated":"2022-04-08T07:33:01Z","success":1,"file_name":"2020_LifeScienceAlliance_Bersini.pdf","file_size":2653960,"file_id":"11137","content_type":"application/pdf","checksum":"3bf33e7e93bef7823287807206b69b38","access_level":"open_access","relation":"main_file"}],"oa_version":"Published Version","language":[{"iso":"eng"}],"keyword":["Health","Toxicology and Mutagenesis","Plant Science","Biochemistry","Genetics and Molecular Biology (miscellaneous)","Ecology"],"external_id":{"pmid":["31959624"]},"year":"2020","volume":3,"intvolume":"         3","_id":"11058","date_updated":"2024-10-14T11:18:41Z","status":"public","article_processing_charge":"No","publisher":"Life Science Alliance","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["570"],"oa":1,"fulldoi":"https://doi.org/10.26508/lsa.201900623","day":"01","scopus_import":"1","article_type":"original","file_date_updated":"2022-04-08T07:33:01Z","publication_status":"published","date_published":"2020-01-01T00:00:00Z","type":"journal_article","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"article_number":"e201900623","month":"01","author":[{"full_name":"Bersini, Simone","last_name":"Bersini","first_name":"Simone"},{"first_name":"Nikki K","last_name":"Lytle","full_name":"Lytle, Nikki K"},{"full_name":"Schulte, Roberta","last_name":"Schulte","first_name":"Roberta"},{"full_name":"Huang, Ling","last_name":"Huang","first_name":"Ling"},{"first_name":"Geoffrey M","last_name":"Wahl","full_name":"Wahl, Geoffrey M"},{"full_name":"HETZER, Martin W","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","first_name":"Martin W"}],"date_created":"2022-04-07T07:44:18Z","citation":{"ama":"Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. <i>Life Science Alliance</i>. 2020;3(1). doi:<a href=\"https://doi.org/10.26508/lsa.201900623\">10.26508/lsa.201900623</a>","ista":"Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. 2020. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Science Alliance. 3(1), e201900623.","apa":"Bersini, S., Lytle, N. K., Schulte, R., Huang, L., Wahl, G. M., &#38; Hetzer, M. (2020). Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. <i>Life Science Alliance</i>. Life Science Alliance. <a href=\"https://doi.org/10.26508/lsa.201900623\">https://doi.org/10.26508/lsa.201900623</a>","mla":"Bersini, Simone, et al. “Nup93 Regulates Breast Tumor Growth by Modulating Cell Proliferation and Actin Cytoskeleton Remodeling.” <i>Life Science Alliance</i>, vol. 3, no. 1, e201900623, Life Science Alliance, 2020, doi:<a href=\"https://doi.org/10.26508/lsa.201900623\">10.26508/lsa.201900623</a>.","ieee":"S. Bersini, N. K. Lytle, R. Schulte, L. Huang, G. M. Wahl, and M. Hetzer, “Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling,” <i>Life Science Alliance</i>, vol. 3, no. 1. Life Science Alliance, 2020.","chicago":"Bersini, Simone, Nikki K Lytle, Roberta Schulte, Ling Huang, Geoffrey M Wahl, and Martin Hetzer. “Nup93 Regulates Breast Tumor Growth by Modulating Cell Proliferation and Actin Cytoskeleton Remodeling.” <i>Life Science Alliance</i>. Life Science Alliance, 2020. <a href=\"https://doi.org/10.26508/lsa.201900623\">https://doi.org/10.26508/lsa.201900623</a>.","short":"S. Bersini, N.K. Lytle, R. Schulte, L. Huang, G.M. Wahl, M. Hetzer, Life Science Alliance 3 (2020)."},"publication_identifier":{"issn":["2575-1077"]},"doi":"10.26508/lsa.201900623","title":"Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling","publication":"Life Science Alliance","extern":"1","issue":"1","quality_controlled":"1","pmid":1}]