[{"article_type":"original","year":"2019","_id":"10622","intvolume":"        19","day":"27","date_updated":"2022-01-13T15:41:24Z","keyword":["mechanical engineering","condensed matter physics","general materials science","general chemistry","bioengineering"],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ista":"Polshyn H, Naibert T, Budakian R. 2019. Manipulating multivortex states in superconducting structures. Nano Letters. 19(8), 5476–5482.","ama":"Polshyn H, Naibert T, Budakian R. Manipulating multivortex states in superconducting structures. <i>Nano Letters</i>. 2019;19(8):5476-5482. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.9b01983\">10.1021/acs.nanolett.9b01983</a>","chicago":"Polshyn, Hryhoriy, Tyler Naibert, and Raffi Budakian. “Manipulating Multivortex States in Superconducting Structures.” <i>Nano Letters</i>. American Chemical Society, 2019. <a href=\"https://doi.org/10.1021/acs.nanolett.9b01983\">https://doi.org/10.1021/acs.nanolett.9b01983</a>.","ieee":"H. Polshyn, T. Naibert, and R. Budakian, “Manipulating multivortex states in superconducting structures,” <i>Nano Letters</i>, vol. 19, no. 8. American Chemical Society, pp. 5476–5482, 2019.","short":"H. Polshyn, T. Naibert, R. Budakian, Nano Letters 19 (2019) 5476–5482.","apa":"Polshyn, H., Naibert, T., &#38; Budakian, R. (2019). Manipulating multivortex states in superconducting structures. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.9b01983\">https://doi.org/10.1021/acs.nanolett.9b01983</a>","mla":"Polshyn, Hryhoriy, et al. “Manipulating Multivortex States in Superconducting Structures.” <i>Nano Letters</i>, vol. 19, no. 8, American Chemical Society, 2019, pp. 5476–82, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.9b01983\">10.1021/acs.nanolett.9b01983</a>."},"doi":"10.1021/acs.nanolett.9b01983","quality_controlled":"1","oa_version":"Preprint","issue":"8","month":"06","volume":19,"acknowledgement":"We are grateful to Nadya Mason, Taylor Hughes, and Alexey Bezryadin for useful discussions. This work was supported by the DOE Basic Energy Sciences under DE-SC0012649 and the Department of Physics and the Frederick Seitz Materials Research Laboratory Central Facilities at the University of Illinois.","external_id":{"arxiv":["1905.06303"],"pmid":["31246034"]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1905.06303"}],"author":[{"orcid":"0000-0001-8223-8896","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy","first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48"},{"last_name":"Naibert","full_name":"Naibert, Tyler","first_name":"Tyler"},{"last_name":"Budakian","full_name":"Budakian, Raffi","first_name":"Raffi"}],"oa":1,"publication_identifier":{"eissn":["1530-6992"],"issn":["1530-6984"]},"publication_status":"published","extern":"1","publisher":"American Chemical Society","scopus_import":"1","date_published":"2019-06-27T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"We demonstrate a method for manipulating small ensembles of vortices in multiply connected superconducting structures. A micron-size magnetic particle attached to the tip of a silicon cantilever is used to locally apply magnetic flux through the superconducting structure. By scanning the tip over the surface of the device and by utilizing the dynamical coupling between the vortices and the cantilever, a high-resolution spatial map of the different vortex configurations is obtained. Moving the tip to a particular location in the map stabilizes a distinct multivortex configuration. Thus, the scanning of the tip over a particular trajectory in space permits nontrivial operations to be performed, such as braiding of individual vortices within a larger vortex ensemble—a key capability required by many proposals for topological quantum computing."}],"title":"Manipulating multivortex states in superconducting structures","publication":"Nano Letters","status":"public","pmid":1,"date_created":"2022-01-13T15:11:14Z","article_processing_charge":"No","page":"5476-5482","arxiv":1,"language":[{"iso":"eng"}]},{"acknowledgement":"We thank J. Zhu and H. Zhou for experimental assistance and D. Shahar, A. Millis, O. Vafek, M. Zaletel, L. Balents, C. Xu, A. Bernevig, L. Fu, M. Koshino, and P. Moon for helpful discussions.","month":"01","volume":363,"issue":"6431","doi":"10.1126/science.aav1910","quality_controlled":"1","oa_version":"Preprint","citation":{"mla":"Yankowitz, Matthew, et al. “Tuning Superconductivity in Twisted Bilayer Graphene.” <i>Science</i>, vol. 363, no. 6431, American Association for the Advancement of Science (AAAS), 2019, pp. 1059–64, doi:<a href=\"https://doi.org/10.1126/science.aav1910\">10.1126/science.aav1910</a>.","apa":"Yankowitz, M., Chen, S., Polshyn, H., Zhang, Y., Watanabe, K., Taniguchi, T., … Dean, C. R. (2019). Tuning superconductivity in twisted bilayer graphene. <i>Science</i>. American Association for the Advancement of Science (AAAS). <a href=\"https://doi.org/10.1126/science.aav1910\">https://doi.org/10.1126/science.aav1910</a>","short":"M. Yankowitz, S. Chen, H. Polshyn, Y. Zhang, K. Watanabe, T. Taniguchi, D. Graf, A.F. Young, C.R. Dean, Science 363 (2019) 1059–1064.","ieee":"M. Yankowitz <i>et al.</i>, “Tuning superconductivity in twisted bilayer graphene,” <i>Science</i>, vol. 363, no. 6431. American Association for the Advancement of Science (AAAS), pp. 1059–1064, 2019.","chicago":"Yankowitz, Matthew, Shaowen Chen, Hryhoriy Polshyn, Yuxuan Zhang, K. Watanabe, T. Taniguchi, David Graf, Andrea F. Young, and Cory R. Dean. “Tuning Superconductivity in Twisted Bilayer Graphene.” <i>Science</i>. American Association for the Advancement of Science (AAAS), 2019. <a href=\"https://doi.org/10.1126/science.aav1910\">https://doi.org/10.1126/science.aav1910</a>.","ista":"Yankowitz M, Chen S, Polshyn H, Zhang Y, Watanabe K, Taniguchi T, Graf D, Young AF, Dean CR. 2019. Tuning superconductivity in twisted bilayer graphene. Science. 363(6431), 1059–1064.","ama":"Yankowitz M, Chen S, Polshyn H, et al. Tuning superconductivity in twisted bilayer graphene. <i>Science</i>. 2019;363(6431):1059-1064. doi:<a href=\"https://doi.org/10.1126/science.aav1910\">10.1126/science.aav1910</a>"},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_updated":"2022-01-14T13:48:32Z","day":"24","keyword":["multidisciplinary"],"_id":"10625","intvolume":"       363","article_type":"original","year":"2019","arxiv":1,"language":[{"iso":"eng"}],"status":"public","pmid":1,"date_created":"2022-01-14T12:14:58Z","article_processing_charge":"No","page":"1059-1064","title":"Tuning superconductivity in twisted bilayer graphene","publication":"Science","extern":"1","publisher":"American Association for the Advancement of Science (AAAS)","scopus_import":"1","type":"journal_article","date_published":"2019-01-24T00:00:00Z","abstract":[{"text":"The discovery of superconductivity and exotic insulating phases in twisted bilayer graphene has established this material as a model system of strongly correlated electrons. To achieve superconductivity, the two layers of graphene need to be at a very precise angle with respect to each other. Yankowitz et al. now show that another experimental knob, hydrostatic pressure, can be used to tune the phase diagram of twisted bilayer graphene (see the Perspective by Feldman). Applying pressure increased the coupling between the layers, which shifted the superconducting transition to higher angles and somewhat higher temperatures.","lang":"eng"}],"author":[{"first_name":"Matthew","last_name":"Yankowitz","full_name":"Yankowitz, Matthew"},{"first_name":"Shaowen","last_name":"Chen","full_name":"Chen, Shaowen"},{"id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy","last_name":"Polshyn","orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy"},{"first_name":"Yuxuan","full_name":"Zhang, Yuxuan","last_name":"Zhang"},{"last_name":"Watanabe","full_name":"Watanabe, K.","first_name":"K."},{"full_name":"Taniguchi, T.","last_name":"Taniguchi","first_name":"T."},{"first_name":"David","last_name":"Graf","full_name":"Graf, David"},{"last_name":"Young","full_name":"Young, Andrea F.","first_name":"Andrea F."},{"last_name":"Dean","full_name":"Dean, Cory R.","first_name":"Cory R."}],"oa":1,"publication_status":"published","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"external_id":{"arxiv":["1808.07865"],"pmid":["30679385 "]},"main_file_link":[{"url":"https://arxiv.org/abs/1808.07865","open_access":"1"}]},{"quality_controlled":"1","publication":"Journal Club for Condensed Matter Physics","oa_version":"Published Version","title":"New correlated phenomena in magic-angle twisted bilayer graphene/s","doi":"10.36471/jccm_february_2019_03","status":"public","date_created":"2022-01-25T15:09:58Z","article_processing_charge":"No","volume":"03","month":"02","language":[{"iso":"eng"}],"article_type":"original","year":"2019","main_file_link":[{"url":"https://www.condmatjclub.org/?p=3541","open_access":"1"}],"intvolume":"         3","_id":"10664","oa":1,"publication_status":"published","date_updated":"2025-01-14T14:28:17Z","day":"28","author":[{"full_name":"Yankowitz, Mathew","last_name":"Yankowitz","first_name":"Mathew"},{"first_name":"Shaowen","last_name":"Chen","full_name":"Chen, Shaowen"},{"id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896","last_name":"Polshyn"},{"full_name":"Watanabe, K.","last_name":"Watanabe","first_name":"K."},{"first_name":"T.","full_name":"Taniguchi, T.","last_name":"Taniguchi"},{"last_name":"Graf","full_name":"Graf, David","first_name":"David"},{"first_name":"Andrea F.","full_name":"Young, Andrea F.","last_name":"Young"},{"first_name":"Cory R.","last_name":"Dean","full_name":"Dean, Cory R."},{"full_name":"Sharpe, Aaron L.","last_name":"Sharpe","first_name":"Aaron L."},{"first_name":"E.J.","last_name":"Fox","full_name":"Fox, E.J."},{"full_name":"Barnard, A.W.","last_name":"Barnard","first_name":"A.W."},{"first_name":"Joe","full_name":"Finney, Joe","last_name":"Finney"}],"extern":"1","publisher":"Simons Foundation ; University of California, Riverside","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"M. Yankowitz, S. Chen, H. Polshyn, K. Watanabe, T. Taniguchi, D. Graf, A.F. Young, C.R. Dean, A.L. Sharpe, E.J. Fox, A.W. Barnard, J. Finney, Journal Club for Condensed Matter Physics 03 (2019).","ista":"Yankowitz M, Chen S, Polshyn H, Watanabe K, Taniguchi T, Graf D, Young AF, Dean CR, Sharpe AL, Fox EJ, Barnard AW, Finney J. 2019. New correlated phenomena in magic-angle twisted bilayer graphene/s. Journal Club for Condensed Matter Physics. 03.","ieee":"M. Yankowitz <i>et al.</i>, “New correlated phenomena in magic-angle twisted bilayer graphene/s,” <i>Journal Club for Condensed Matter Physics</i>, vol. 03. Simons Foundation ; University of California, Riverside, 2019.","ama":"Yankowitz M, Chen S, Polshyn H, et al. New correlated phenomena in magic-angle twisted bilayer graphene/s. <i>Journal Club for Condensed Matter Physics</i>. 2019;03. doi:<a href=\"https://doi.org/10.36471/jccm_february_2019_03\">10.36471/jccm_february_2019_03</a>","chicago":"Yankowitz, Mathew, Shaowen Chen, Hryhoriy Polshyn, K. Watanabe, T. Taniguchi, David Graf, Andrea F. Young, et al. “New Correlated Phenomena in Magic-Angle Twisted Bilayer Graphene/S.” <i>Journal Club for Condensed Matter Physics</i>. Simons Foundation ; University of California, Riverside, 2019. <a href=\"https://doi.org/10.36471/jccm_february_2019_03\">https://doi.org/10.36471/jccm_february_2019_03</a>.","mla":"Yankowitz, Mathew, et al. “New Correlated Phenomena in Magic-Angle Twisted Bilayer Graphene/S.” <i>Journal Club for Condensed Matter Physics</i>, vol. 03, Simons Foundation ; University of California, Riverside, 2019, doi:<a href=\"https://doi.org/10.36471/jccm_february_2019_03\">10.36471/jccm_february_2019_03</a>.","apa":"Yankowitz, M., Chen, S., Polshyn, H., Watanabe, K., Taniguchi, T., Graf, D., … Finney, J. (2019). New correlated phenomena in magic-angle twisted bilayer graphene/s. <i>Journal Club for Condensed Matter Physics</i>. Simons Foundation ; University of California, Riverside. <a href=\"https://doi.org/10.36471/jccm_february_2019_03\">https://doi.org/10.36471/jccm_february_2019_03</a>"},"type":"journal_article","date_published":"2019-02-28T00:00:00Z","abstract":[{"lang":"eng","text":"Since the discovery of correlated insulators and superconductivity in magic-angle twisted bilayer graphene (tBLG) ([1, 2], JCCM April 2018), theorists have been excitedly pursuing the alluring mix of band topology, symmetry breaking, Mott insulators and superconductivity at play, as well as the potential relation (if any) to high-Tc physics. Now a new stream\r\nof experimental work is arriving which further enriches the story. To briefly recap Episodes 1 and 2 (JCCM April and November 2018), when two graphene layers are stacked with a small rotational mismatch θ, the resulting long-wavelength moire pattern leads to a superlattice potential which reconstructs the low energy band structure. When θ approaches the “magic-angle” θM ∼ 1 ◦, the band structure features eight nearly-flat bands which fill when the electron number per moire unit cell, n/n0, lies between −4 < n/n0 < 4. The bands can be counted as 8 = 2 × 2 × 2: for each spin (2×) and valley (2×) characteristic of monolayergraphene, tBLG has has 2× flat bands which cross at mini-Dirac points."}]},{"main_file_link":[{"open_access":"1","url":"https://meetings.aps.org/Meeting/MAR19/Session/L14.6"}],"article_number":"L14.00006","type":"conference","abstract":[{"text":"Bilayer graphene, rotationally faulted to ~1.1 degree misalignment, has recently been shown to host superconducting and resistive states associated with the formation of a flat electronic band. While numerous theories exist for the origins of both states, direct validation of these theories remains an outstanding experimental problem. Here, we focus on the resistive states occurring at commensurate filling (1/2, 1/4, and 3/4) of the two lowest superlattice bands. We test theoretical proposals that these states arise due to broken spin—and/or valley—symmetry by performing direct magnetic imaging with nanoscale SQUID-on-tip microscopy. This technique provides single-spin resolved magnetometry on sub-100nm length scales. I will present imaging data from our 4.2K nSOT microscope on graphite-gated twisted bilayers near the flat band condition and discuss the implications for the physics of the commensurate resistive states.","lang":"eng"}],"date_published":"2019-03-01T00:00:00Z","extern":"1","publisher":"American Physical Society","publication_identifier":{"issn":["0003-0503"]},"publication_status":"published","oa":1,"author":[{"last_name":"Serlin","full_name":"Serlin, Marec","first_name":"Marec"},{"full_name":"Tschirhart, Charles","last_name":"Tschirhart","first_name":"Charles"},{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","orcid":"0000-0001-8223-8896","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy"},{"full_name":"Zhu, Jiacheng","last_name":"Zhu","first_name":"Jiacheng"},{"first_name":"Martin E.","last_name":"Huber","full_name":"Huber, Martin E."},{"first_name":"Andrea","last_name":"Young","full_name":"Young, Andrea"}],"article_processing_charge":"No","date_created":"2022-02-04T11:54:21Z","status":"public","publication":"APS March Meeting 2019","title":"Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy","alternative_title":["Bulletin of the American Physical Society"],"language":[{"iso":"eng"}],"conference":{"name":"APS: American Physical Society","start_date":"2019-03-04","end_date":"2019-03-08","location":"Boston, MA, United States"},"intvolume":"        64","_id":"10722","year":"2019","citation":{"apa":"Serlin, M., Tschirhart, C., Polshyn, H., Zhu, J., Huber, M. E., &#38; Young, A. (2019). Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States: American Physical Society.","mla":"Serlin, Marec, et al. “Direct Imaging of Magnetic Structure in Twisted Bilayer Graphene with Scanning NanoSQUID-On-Tip Microscopy.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, L14.00006, American Physical Society, 2019.","chicago":"Serlin, Marec, Charles Tschirhart, Hryhoriy Polshyn, Jiacheng Zhu, Martin E. Huber, and Andrea Young. “Direct Imaging of Magnetic Structure in Twisted Bilayer Graphene with Scanning NanoSQUID-On-Tip Microscopy.” In <i>APS March Meeting 2019</i>, Vol. 64. American Physical Society, 2019.","ama":"Serlin M, Tschirhart C, Polshyn H, Zhu J, Huber ME, Young A. Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy. In: <i>APS March Meeting 2019</i>. Vol 64. American Physical Society; 2019.","ista":"Serlin M, Tschirhart C, Polshyn H, Zhu J, Huber ME, Young A. 2019. Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy. APS March Meeting 2019. APS: American Physical Society, Bulletin of the American Physical Society, vol. 64, L14.00006.","ieee":"M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, M. E. Huber, and A. Young, “Direct Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip microscopy,” in <i>APS March Meeting 2019</i>, Boston, MA, United States, 2019, vol. 64, no. 2.","short":"M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, M.E. Huber, A. Young, in:, APS March Meeting 2019, American Physical Society, 2019."},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_updated":"2022-02-08T10:25:30Z","day":"01","issue":"2","oa_version":"Published Version","quality_controlled":"1","volume":64,"month":"03"},{"day":"01","date_updated":"2022-02-04T13:59:47Z","author":[{"full_name":"Zhou, Haoxin","last_name":"Zhou","first_name":"Haoxin"},{"orcid":"0000-0001-8223-8896","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy"},{"last_name":"Tanaguchi","full_name":"Tanaguchi, Takashi","first_name":"Takashi"},{"full_name":"Watanabe, Kenji","last_name":"Watanabe","first_name":"Kenji"},{"last_name":"Young","full_name":"Young, Andrea","first_name":"Andrea"}],"oa":1,"publication_identifier":{"issn":["0003-0503"]},"publication_status":"published","publisher":"American Physical Society","extern":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","citation":{"chicago":"Zhou, Haoxin, Hryhoriy Polshyn, Takashi Tanaguchi, Kenji Watanabe, and Andrea Young. “Spin Wave Transport through Electron Solids and Fractional Quantum Hall Liquids in Graphene.” In <i>APS March Meeting 2019</i>, Vol. 64. American Physical Society, 2019.","ama":"Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. Spin wave transport through electron solids and fractional quantum Hall liquids in graphene. In: <i>APS March Meeting 2019</i>. Vol 64. American Physical Society; 2019.","ieee":"H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, and A. Young, “Spin wave transport through electron solids and fractional quantum Hall liquids in graphene,” in <i>APS March Meeting 2019</i>, Boston, MA, United States, 2019, vol. 64, no. 2.","ista":"Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. 2019. Spin wave transport through electron solids and fractional quantum Hall liquids in graphene. APS March Meeting 2019. APS: American Physical Society vol. 64, P01.00004.","short":"H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, A. Young, in:, APS March Meeting 2019, American Physical Society, 2019.","apa":"Zhou, H., Polshyn, H., Tanaguchi, T., Watanabe, K., &#38; Young, A. (2019). Spin wave transport through electron solids and fractional quantum Hall liquids in graphene. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States: American Physical Society.","mla":"Zhou, Haoxin, et al. “Spin Wave Transport through Electron Solids and Fractional Quantum Hall Liquids in Graphene.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, P01.00004, American Physical Society, 2019."},"date_published":"2019-03-01T00:00:00Z","abstract":[{"text":"In monolayer graphene, the interplay of electronic correlations with the internal spin- and valley- degrees of freedom leads to a complex phase diagram of isospin symmetry breaking at high magnetic fields. Recently, Wei et al. (Science (2018)) demonstrated that spin waves can be electrically generated and detected in graphene heterojunctions, allowing direct experiment access to the spin degree of freedom. Here, we apply this technique to high quality graphite-gated graphene devices showing robust fractional quantum Hall phases and isospin phase transitions. We use an edgeless Corbino geometry to eliminate the contributions of edge states to the spin-wave mediated nonlocal voltage, allowing unambiguous identification of spin wave transport signatures. Our data reveal two phases within the ν = 1 plateau. For exactly ν=1, charge is localized but spin waves propagate freely while small carrier doping completely quenches the low-energy spin-wave transport, even as those charges remain localized. We identify this new phase as a spin textured electron solid. We also find that spin-wave transport is modulated by phase transitions in the valley order that preserve spin polarization, suggesting that this technique is sensitive to both spin and valley order.","lang":"eng"}],"type":"conference","article_number":"P01.00004","year":"2019","main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR19/Session/P01.4","open_access":"1"}],"_id":"10723","intvolume":"        64","month":"03","volume":64,"conference":{"location":"Boston, MA, United States","name":"APS: American Physical Society","start_date":"2019-03-04","end_date":"2019-03-08"},"language":[{"iso":"eng"}],"title":"Spin wave transport through electron solids and fractional quantum Hall liquids in graphene","quality_controlled":"1","publication":"APS March Meeting 2019","oa_version":"Published Version","status":"public","article_processing_charge":"No","date_created":"2022-02-04T12:14:02Z","issue":"2"},{"oa":1,"publication_identifier":{"issn":["0003-0503"]},"publication_status":"published","author":[{"orcid":"0000-0001-8223-8896","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy"},{"full_name":"Zhang, Yuxuan","last_name":"Zhang","first_name":"Yuxuan"},{"first_name":"Matthew","full_name":"Yankowitz, Matthew","last_name":"Yankowitz"},{"first_name":"Shaowen","full_name":"Chen, Shaowen","last_name":"Chen"},{"full_name":"Taniguchi, Takashi","last_name":"Taniguchi","first_name":"Takashi"},{"first_name":"Kenji","full_name":"Watanabe, Kenji","last_name":"Watanabe"},{"full_name":"Graf, David E.","last_name":"Graf","first_name":"David E."},{"full_name":"Dean, Cory R.","last_name":"Dean","first_name":"Cory R."},{"full_name":"Young, Andrea","last_name":"Young","first_name":"Andrea"}],"extern":"1","publisher":"American Physical Society","abstract":[{"lang":"eng","text":"Twisted bilayer graphene (tBLG) near the flat band condition is a versatile new platform for the study of correlated physics in 2D. Resistive states have been observed at several commensurate fillings of the flat miniband, along with superconducting states near half filling. To better understand the electronic structure of this system, we study electronic transport of graphite gated superconducting tBLG devices in the normal regime. At high magnetic fields, we observe full lifting of the spin and valley degeneracy. The transitions in the splitting of this four-fold degeneracy as a function of carrier density indicate Landau level (LL) crossings, which tilted field measurements show occur between LLs with different valley polarization. Similar LL structure measured in two devices, one with twist angle θ=1.08° at ambient pressure and one at θ=1.27° and 1.33GPa, suggests that the dimensionless combination of twist angle and interlayer coupling controls the relevant details of the band structure. In addition, we find that the temperature dependence of the resistance at B=0 shows linear growth at several hundred Ohm/K in a broad range of temperatures. We discuss the implications for modeling the scattering processes in this system."}],"date_published":"2019-03-01T00:00:00Z","type":"conference","main_file_link":[{"url":"https://meetings.aps.org/Meeting/MAR19/Session/V14.8","open_access":"1"}],"article_number":"V14.00008","language":[{"iso":"eng"}],"conference":{"location":"Boston, MA, United States","name":"APS: American Physical Society","end_date":"2019-03-08","start_date":"2019-03-04"},"publication":"APS March Meeting 2019","alternative_title":["Bulletin of the American Physical Society"],"title":"Normal state transport in superconducting twisted bilayer graphene","status":"public","date_created":"2022-02-04T12:25:04Z","article_processing_charge":"No","date_updated":"2022-02-08T10:23:13Z","day":"01","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","citation":{"short":"H. Polshyn, Y. Zhang, M. Yankowitz, S. Chen, T. Taniguchi, K. Watanabe, D.E. Graf, C.R. Dean, A. Young, in:, APS March Meeting 2019, American Physical Society, 2019.","ista":"Polshyn H, Zhang Y, Yankowitz M, Chen S, Taniguchi T, Watanabe K, Graf DE, Dean CR, Young A. 2019. Normal state transport in superconducting twisted bilayer graphene. APS March Meeting 2019. APS: American Physical Society, Bulletin of the American Physical Society, vol. 64, V14.00008.","chicago":"Polshyn, Hryhoriy, Yuxuan Zhang, Matthew Yankowitz, Shaowen Chen, Takashi Taniguchi, Kenji Watanabe, David E. Graf, Cory R. Dean, and Andrea Young. “Normal State Transport in Superconducting Twisted Bilayer Graphene.” In <i>APS March Meeting 2019</i>, Vol. 64. American Physical Society, 2019.","ama":"Polshyn H, Zhang Y, Yankowitz M, et al. Normal state transport in superconducting twisted bilayer graphene. In: <i>APS March Meeting 2019</i>. Vol 64. American Physical Society; 2019.","ieee":"H. Polshyn <i>et al.</i>, “Normal state transport in superconducting twisted bilayer graphene,” in <i>APS March Meeting 2019</i>, Boston, MA, United States, 2019, vol. 64, no. 2.","mla":"Polshyn, Hryhoriy, et al. “Normal State Transport in Superconducting Twisted Bilayer Graphene.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, V14.00008, American Physical Society, 2019.","apa":"Polshyn, H., Zhang, Y., Yankowitz, M., Chen, S., Taniguchi, T., Watanabe, K., … Young, A. (2019). Normal state transport in superconducting twisted bilayer graphene. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States: American Physical Society."},"year":"2019","intvolume":"        64","_id":"10724","volume":64,"month":"03","quality_controlled":"1","oa_version":"Published Version","issue":"2"},{"title":"Correlated insulating and superconducting phases in twisted bilayer graphene","alternative_title":["Bulletin of the American Physical Society"],"publication":"APS March Meeting 2019","article_processing_charge":"No","date_created":"2022-02-04T13:48:04Z","status":"public","conference":{"location":"Boston, MA, United States","name":"APS: American Physical Society","end_date":"2019-03-08","start_date":"2019-03-04"},"language":[{"iso":"eng"}],"article_number":"R14.00004","main_file_link":[{"open_access":"1","url":"https://meetings.aps.org/Meeting/MAR19/Session/R14.4"}],"author":[{"full_name":"Chen, Shaowen","last_name":"Chen","first_name":"Shaowen"},{"first_name":"Matthew","full_name":"Yankowitz, Matthew","last_name":"Yankowitz"},{"id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896","last_name":"Polshyn"},{"first_name":"Kenji","last_name":"Watanabe","full_name":"Watanabe, Kenji"},{"first_name":"Takashi","full_name":"Taniguchi, Takashi","last_name":"Taniguchi"},{"last_name":"Graf","full_name":"Graf, David E.","first_name":"David E."},{"first_name":"Andrea","last_name":"Young","full_name":"Young, Andrea"},{"full_name":"Dean, Cory R.","last_name":"Dean","first_name":"Cory R."}],"publication_identifier":{"issn":["0003-0503"]},"publication_status":"published","related_material":{"link":[{"url":"https://arxiv.org/abs/1808.07865","relation":"used_in_publication"}]},"oa":1,"abstract":[{"text":"Bilayer graphene with ~ 1.1 degrees twist mismatch between the layers hosts a low energy flat band in which the Coulomb interaction is large relative to the bandwidth, promoting correlated insulating states at half band filling, and superconducting (SC) phases with dome-like structure neighboring correlated insulating states. Here we show measurements of a dual-graphite-gated twisted bilayer graphene device, which minimizes charge inhomogeneity. We observe new correlated phases, including for the first time a SC pocket near half-filling of the electron-doped band and resistive states at quarter-filling of both bands that emerge in a magnetic field. Changing the layer polarization with vertical electric field reveals an unexpected competition between SC and correlated insulator phases, which we interpret to result from differences in disorder of each graphene layer and underscores the spatial inhomogeneity like twist angle as a significant source of disorder in these devices [1].","lang":"eng"}],"type":"conference","date_published":"2019-03-01T00:00:00Z","extern":"1","publisher":"American Physical Society","oa_version":"Published Version","quality_controlled":"1","issue":"2","month":"03","volume":64,"year":"2019","_id":"10725","intvolume":"        64","day":"01","date_updated":"2022-02-08T10:24:13Z","citation":{"ista":"Chen S, Yankowitz M, Polshyn H, Watanabe K, Taniguchi T, Graf DE, Young A, Dean CR. 2019. Correlated insulating and superconducting phases in twisted bilayer graphene. APS March Meeting 2019. APS: American Physical Society, Bulletin of the American Physical Society, vol. 64, R14.00004.","ieee":"S. Chen <i>et al.</i>, “Correlated insulating and superconducting phases in twisted bilayer graphene,” in <i>APS March Meeting 2019</i>, Boston, MA, United States, 2019, vol. 64, no. 2.","chicago":"Chen, Shaowen, Matthew Yankowitz, Hryhoriy Polshyn, Kenji Watanabe, Takashi Taniguchi, David E. Graf, Andrea Young, and Cory R. Dean. “Correlated Insulating and Superconducting Phases in Twisted Bilayer Graphene.” In <i>APS March Meeting 2019</i>, Vol. 64. American Physical Society, 2019.","ama":"Chen S, Yankowitz M, Polshyn H, et al. Correlated insulating and superconducting phases in twisted bilayer graphene. In: <i>APS March Meeting 2019</i>. Vol 64. American Physical Society; 2019.","short":"S. Chen, M. Yankowitz, H. Polshyn, K. Watanabe, T. Taniguchi, D.E. Graf, A. Young, C.R. Dean, in:, APS March Meeting 2019, American Physical Society, 2019.","apa":"Chen, S., Yankowitz, M., Polshyn, H., Watanabe, K., Taniguchi, T., Graf, D. E., … Dean, C. R. (2019). Correlated insulating and superconducting phases in twisted bilayer graphene. In <i>APS March Meeting 2019</i> (Vol. 64). Boston, MA, United States: American Physical Society.","mla":"Chen, Shaowen, et al. “Correlated Insulating and Superconducting Phases in Twisted Bilayer Graphene.” <i>APS March Meeting 2019</i>, vol. 64, no. 2, R14.00004, American Physical Society, 2019."},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9"},{"citation":{"mla":"Ionica, Sorina, et al. “Modular Invariants for Genus 3 Hyperelliptic Curves.” <i>Research in Number Theory</i>, vol. 5, 9, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1007/s40993-018-0146-6\">10.1007/s40993-018-0146-6</a>.","apa":"Ionica, S., Kılıçer, P., Lauter, K., Lorenzo García, E., Manzateanu, M.-A., Massierer, M., &#38; Vincent, C. (2019). Modular invariants for genus 3 hyperelliptic curves. <i>Research in Number Theory</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s40993-018-0146-6\">https://doi.org/10.1007/s40993-018-0146-6</a>","short":"S. Ionica, P. Kılıçer, K. Lauter, E. Lorenzo García, M.-A. Manzateanu, M. Massierer, C. Vincent, Research in Number Theory 5 (2019).","ama":"Ionica S, Kılıçer P, Lauter K, et al. Modular invariants for genus 3 hyperelliptic curves. <i>Research in Number Theory</i>. 2019;5. doi:<a href=\"https://doi.org/10.1007/s40993-018-0146-6\">10.1007/s40993-018-0146-6</a>","ista":"Ionica S, Kılıçer P, Lauter K, Lorenzo García E, Manzateanu M-A, Massierer M, Vincent C. 2019. Modular invariants for genus 3 hyperelliptic curves. Research in Number Theory. 5, 9.","ieee":"S. Ionica <i>et al.</i>, “Modular invariants for genus 3 hyperelliptic curves,” <i>Research in Number Theory</i>, vol. 5. Springer Nature, 2019.","chicago":"Ionica, Sorina, Pınar Kılıçer, Kristin Lauter, Elisa Lorenzo García, Maria-Adelina Manzateanu, Maike Massierer, and Christelle Vincent. “Modular Invariants for Genus 3 Hyperelliptic Curves.” <i>Research in Number Theory</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1007/s40993-018-0146-6\">https://doi.org/10.1007/s40993-018-0146-6</a>."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","keyword":["Algebra and Number Theory"],"day":"02","date_updated":"2023-09-05T15:39:31Z","_id":"10874","intvolume":"         5","year":"2019","article_type":"original","acknowledgement":"The authors would like to thank the Lorentz Center in Leiden for hosting the Women in Numbers Europe 2 workshop and providing a productive and enjoyable environment for our initial work on this project. We are grateful to the organizers of WIN-E2, Irene Bouw, Rachel Newton and Ekin Ozman, for making this conference and this collaboration possible. We\r\nthank Irene Bouw and Christophe Ritzenhaler for helpful discussions. Ionica acknowledges support from the Thomas Jefferson Fund of the Embassy of France in the United States and the FACE Foundation. Most of Kılıçer’s work was carried out during her stay in Universiteit Leiden and Carl von Ossietzky Universität Oldenburg. Massierer was supported by the Australian Research Council (DP150101689). Vincent is supported by the National Science Foundation under Grant No. DMS-1802323 and by the Thomas Jefferson Fund of the Embassy of France in the United States and the FACE Foundation. ","month":"01","volume":5,"doi":"10.1007/s40993-018-0146-6","oa_version":"Preprint","quality_controlled":"1","type":"journal_article","date_published":"2019-01-02T00:00:00Z","abstract":[{"text":"In this article we prove an analogue of a theorem of Lachaud, Ritzenthaler, and Zykin, which allows us to connect invariants of binary octics to Siegel modular forms of genus 3. We use this connection to show that certain modular functions, when restricted to the hyperelliptic locus, assume values whose denominators are products of powers of primes of bad reduction for the associated hyperelliptic curves. We illustrate our theorem with explicit computations. This work is motivated by the study of the values of these modular functions at CM points of the Siegel upper half-space, which, if their denominators are known, can be used to effectively compute models of (hyperelliptic, in our case) curves with CM.","lang":"eng"}],"publisher":"Springer Nature","scopus_import":"1","author":[{"first_name":"Sorina","full_name":"Ionica, Sorina","last_name":"Ionica"},{"full_name":"Kılıçer, Pınar","last_name":"Kılıçer","first_name":"Pınar"},{"last_name":"Lauter","full_name":"Lauter, Kristin","first_name":"Kristin"},{"first_name":"Elisa","full_name":"Lorenzo García, Elisa","last_name":"Lorenzo García"},{"full_name":"Manzateanu, Maria-Adelina","last_name":"Manzateanu","first_name":"Maria-Adelina","id":"be8d652e-a908-11ec-82a4-e2867729459c"},{"first_name":"Maike","last_name":"Massierer","full_name":"Massierer, Maike"},{"last_name":"Vincent","full_name":"Vincent, Christelle","first_name":"Christelle"}],"publication_identifier":{"issn":["2522-0160"],"eissn":["2363-9555"]},"department":[{"_id":"TiBr"}],"publication_status":"published","oa":1,"external_id":{"arxiv":["1807.08986"]},"article_number":"9","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1807.08986"}],"arxiv":1,"language":[{"iso":"eng"}],"date_created":"2022-03-18T12:09:48Z","article_processing_charge":"No","status":"public","title":"Modular invariants for genus 3 hyperelliptic curves","publication":"Research in Number Theory"},{"year":"2019","intvolume":"        61","_id":"10877","date_updated":"2022-05-17T07:09:47Z","day":"25","citation":{"ista":"Frehse G, Abate A, Adzkiya D, Becchi A, Bu L, Cimatti A, Giacobbe M, Griggio A, Mover S, Mufid MS, Riouak I, Tonetta S, Zaffanella E. 2019. ARCH-COMP19 Category Report: Hybrid systems with piecewise constant dynamics. ARCH19. 6th International Workshop on Applied Verification of Continuous and Hybrid Systems. ARCH: International Workshop on Applied Verification on Continuous and Hybrid Systems, EPiC Series in Computing, vol. 61, 1–13.","ama":"Frehse G, Abate A, Adzkiya D, et al. ARCH-COMP19 Category Report: Hybrid systems with piecewise constant dynamics. In: Frehse G, Althoff M, eds. <i>ARCH19. 6th International Workshop on Applied Verification of Continuous and Hybrid Systems</i>. Vol 61. EasyChair; 2019:1-13. doi:<a href=\"https://doi.org/10.29007/rjwn\">10.29007/rjwn</a>","ieee":"G. Frehse <i>et al.</i>, “ARCH-COMP19 Category Report: Hybrid systems with piecewise constant dynamics,” in <i>ARCH19. 6th International Workshop on Applied Verification of Continuous and Hybrid Systems</i>, Montreal, Canada, 2019, vol. 61, pp. 1–13.","chicago":"Frehse, Goran, Alessandro Abate, Dieky Adzkiya, Anna Becchi, Lei Bu, Alessandro Cimatti, Mirco Giacobbe, et al. “ARCH-COMP19 Category Report: Hybrid Systems with Piecewise Constant Dynamics.” In <i>ARCH19. 6th International Workshop on Applied Verification of Continuous and Hybrid Systems</i>, edited by Goran Frehse and Matthias Althoff, 61:1–13. EasyChair, 2019. <a href=\"https://doi.org/10.29007/rjwn\">https://doi.org/10.29007/rjwn</a>.","short":"G. Frehse, A. Abate, D. Adzkiya, A. Becchi, L. Bu, A. Cimatti, M. Giacobbe, A. Griggio, S. Mover, M.S. Mufid, I. Riouak, S. Tonetta, E. Zaffanella, in:, G. Frehse, M. Althoff (Eds.), ARCH19. 6th International Workshop on Applied Verification of Continuous and Hybrid Systems, EasyChair, 2019, pp. 1–13.","apa":"Frehse, G., Abate, A., Adzkiya, D., Becchi, A., Bu, L., Cimatti, A., … Zaffanella, E. (2019). ARCH-COMP19 Category Report: Hybrid systems with piecewise constant dynamics. In G. Frehse &#38; M. Althoff (Eds.), <i>ARCH19. 6th International Workshop on Applied Verification of Continuous and Hybrid Systems</i> (Vol. 61, pp. 1–13). Montreal, Canada: EasyChair. <a href=\"https://doi.org/10.29007/rjwn\">https://doi.org/10.29007/rjwn</a>","mla":"Frehse, Goran, et al. “ARCH-COMP19 Category Report: Hybrid Systems with Piecewise Constant Dynamics.” <i>ARCH19. 6th International Workshop on Applied Verification of Continuous and Hybrid Systems</i>, edited by Goran Frehse and Matthias Althoff, vol. 61, EasyChair, 2019, pp. 1–13, doi:<a href=\"https://doi.org/10.29007/rjwn\">10.29007/rjwn</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","quality_controlled":"1","doi":"10.29007/rjwn","editor":[{"last_name":"Frehse","full_name":"Frehse, Goran","first_name":"Goran"},{"first_name":"Matthias","last_name":"Althoff","full_name":"Althoff, Matthias"}],"has_accepted_license":"1","volume":61,"month":"05","acknowledgement":"The authors gratefully acknowledge \fnancial support by the European Commission project\r\nUnCoVerCPS under grant number 643921. Lei Bu is supported by the National Natural Science\r\nFoundation of China (No.61572249).","file":[{"content_type":"application/pdf","success":1,"checksum":"4b92e333db7b4e2349501a804dfede69","date_updated":"2022-05-17T06:55:49Z","creator":"dernst","date_created":"2022-05-17T06:55:49Z","relation":"main_file","file_size":346415,"access_level":"open_access","file_id":"11391","file_name":"2019_EPiCs_Frehse.pdf"}],"publication_status":"published","department":[{"_id":"ToHe"}],"publication_identifier":{"issn":["2398-7340"]},"oa":1,"file_date_updated":"2022-05-17T06:55:49Z","author":[{"last_name":"Frehse","full_name":"Frehse, Goran","first_name":"Goran"},{"last_name":"Abate","full_name":"Abate, Alessandro","first_name":"Alessandro"},{"full_name":"Adzkiya, Dieky","last_name":"Adzkiya","first_name":"Dieky"},{"first_name":"Anna","last_name":"Becchi","full_name":"Becchi, Anna"},{"first_name":"Lei","last_name":"Bu","full_name":"Bu, Lei"},{"full_name":"Cimatti, Alessandro","last_name":"Cimatti","first_name":"Alessandro"},{"id":"3444EA5E-F248-11E8-B48F-1D18A9856A87","first_name":"Mirco","full_name":"Giacobbe, Mirco","last_name":"Giacobbe","orcid":"0000-0001-8180-0904"},{"first_name":"Alberto","last_name":"Griggio","full_name":"Griggio, Alberto"},{"first_name":"Sergio","last_name":"Mover","full_name":"Mover, Sergio"},{"last_name":"Mufid","full_name":"Mufid, Muhammad Syifa'ul","first_name":"Muhammad Syifa'ul"},{"first_name":"Idriss","full_name":"Riouak, Idriss","last_name":"Riouak"},{"last_name":"Tonetta","full_name":"Tonetta, Stefano","first_name":"Stefano"},{"last_name":"Zaffanella","full_name":"Zaffanella, Enea","first_name":"Enea"}],"abstract":[{"text":"This report presents the results of a friendly competition for formal verification of continuous and hybrid systems with piecewise constant dynamics. The friendly competition took place as part of the workshop Applied Verification for Continuous and Hybrid Systems (ARCH) in 2019. In this third edition, six tools have been applied to solve five different benchmark problems in the category for piecewise constant dynamics: BACH, Lyse, Hy- COMP, PHAVer/SX, PHAVerLite, and VeriSiMPL. Compared to last year, a new tool has participated (HyCOMP) and PHAVerLite has replaced PHAVer-lite. The result is a snap- shot of the current landscape of tools and the types of benchmarks they are particularly suited for. Due to the diversity of problems, we are not ranking tools, yet the presented results probably provide the most complete assessment of tools for the safety verification of continuous and hybrid systems with piecewise constant dynamics up to this date.","lang":"eng"}],"date_published":"2019-05-25T00:00:00Z","type":"conference","publisher":"EasyChair","scopus_import":"1","ddc":["000"],"publication":"ARCH19. 6th International Workshop on Applied Verification of Continuous and Hybrid Systems","title":"ARCH-COMP19 Category Report: Hybrid systems with piecewise constant dynamics","alternative_title":["EPiC Series in Computing"],"page":"1-13","article_processing_charge":"No","date_created":"2022-03-18T12:29:23Z","status":"public","language":[{"iso":"eng"}],"conference":{"name":"ARCH: International Workshop on Applied Verification on Continuous and Hybrid Systems","start_date":"2019-04-15","end_date":"2019-04-15","location":"Montreal, Canada"}},{"publication":"Discrete and Continuous Dynamical Systems","title":"A mean-field model with discontinuous coefficients for neurons with spatial interaction","page":"3037-3067","article_processing_charge":"No","date_created":"2022-03-18T12:33:34Z","status":"public","language":[{"iso":"eng"}],"corr_author":"1","arxiv":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1708.04156"}],"external_id":{"isi":["000459954800003"],"arxiv":["1708.04156"]},"project":[{"_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","name":"Taming Complexity in Partial Differential Systems","grant_number":"F6504"}],"publication_identifier":{"issn":["1553-5231"]},"department":[{"_id":"JaMa"}],"publication_status":"published","oa":1,"author":[{"last_name":"Flandoli","full_name":"Flandoli, Franco","first_name":"Franco"},{"full_name":"Priola, Enrico","last_name":"Priola","first_name":"Enrico"},{"id":"47491882-F248-11E8-B48F-1D18A9856A87","first_name":"Giovanni A","last_name":"Zanco","full_name":"Zanco, Giovanni A"}],"date_published":"2019-06-01T00:00:00Z","type":"journal_article","abstract":[{"text":"Starting from a microscopic model for a system of neurons evolving in time which individually follow a stochastic integrate-and-fire type model, we study a mean-field limit of the system. Our model is described by a system of SDEs with discontinuous coefficients for the action potential of each neuron and takes into account the (random) spatial configuration of neurons allowing the interaction to depend on it. In the limit as the number of particles tends to infinity, we obtain a nonlinear Fokker-Planck type PDE in two variables, with derivatives only with respect to one variable and discontinuous coefficients. We also study strong well-posedness of the system of SDEs and prove the existence and uniqueness of a weak measure-valued solution to the PDE, obtained as the limit of the laws of the empirical measures for the system of particles.","lang":"eng"}],"publisher":"American Institute of Mathematical Sciences","scopus_import":"1","oa_version":"Preprint","quality_controlled":"1","doi":"10.3934/dcds.2019126","issue":"6","volume":39,"month":"06","acknowledgement":"The second author has been partially supported by INdAM through the GNAMPA Research\r\nProject (2017) “Sistemi stocastici singolari: buona posizione e problemi di controllo”. The third\r\nauthor was partly funded by the Austrian Science Fund (FWF) project F 65.","article_type":"original","year":"2019","intvolume":"        39","_id":"10878","isi":1,"keyword":["Applied Mathematics","Discrete Mathematics and Combinatorics","Analysis"],"day":"01","date_updated":"2025-04-15T08:31:32Z","citation":{"short":"F. Flandoli, E. Priola, G.A. Zanco, Discrete and Continuous Dynamical Systems 39 (2019) 3037–3067.","ieee":"F. Flandoli, E. Priola, and G. A. Zanco, “A mean-field model with discontinuous coefficients for neurons with spatial interaction,” <i>Discrete and Continuous Dynamical Systems</i>, vol. 39, no. 6. American Institute of Mathematical Sciences, pp. 3037–3067, 2019.","ista":"Flandoli F, Priola E, Zanco GA. 2019. A mean-field model with discontinuous coefficients for neurons with spatial interaction. Discrete and Continuous Dynamical Systems. 39(6), 3037–3067.","chicago":"Flandoli, Franco, Enrico Priola, and Giovanni A Zanco. “A Mean-Field Model with Discontinuous Coefficients for Neurons with Spatial Interaction.” <i>Discrete and Continuous Dynamical Systems</i>. American Institute of Mathematical Sciences, 2019. <a href=\"https://doi.org/10.3934/dcds.2019126\">https://doi.org/10.3934/dcds.2019126</a>.","ama":"Flandoli F, Priola E, Zanco GA. A mean-field model with discontinuous coefficients for neurons with spatial interaction. <i>Discrete and Continuous Dynamical Systems</i>. 2019;39(6):3037-3067. doi:<a href=\"https://doi.org/10.3934/dcds.2019126\">10.3934/dcds.2019126</a>","mla":"Flandoli, Franco, et al. “A Mean-Field Model with Discontinuous Coefficients for Neurons with Spatial Interaction.” <i>Discrete and Continuous Dynamical Systems</i>, vol. 39, no. 6, American Institute of Mathematical Sciences, 2019, pp. 3037–67, doi:<a href=\"https://doi.org/10.3934/dcds.2019126\">10.3934/dcds.2019126</a>.","apa":"Flandoli, F., Priola, E., &#38; Zanco, G. A. (2019). A mean-field model with discontinuous coefficients for neurons with spatial interaction. <i>Discrete and Continuous Dynamical Systems</i>. American Institute of Mathematical Sciences. <a href=\"https://doi.org/10.3934/dcds.2019126\">https://doi.org/10.3934/dcds.2019126</a>"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"article_processing_charge":"No","date_created":"2022-03-18T12:36:42Z","status":"public","page":"921-965","title":"Perturbations of continuum random Schrödinger operators with applications to Anderson orthogonality and the spectral shift function","publication":"Journal of Spectral Theory","arxiv":1,"language":[{"iso":"eng"}],"external_id":{"arxiv":["1701.02956"],"isi":["000484709400006"]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1701.02956"}],"date_published":"2019-03-01T00:00:00Z","abstract":[{"text":"We study effects of a bounded and compactly supported perturbation on multidimensional continuum random Schrödinger operators in the region of complete localisation. Our main emphasis is on Anderson orthogonality for random Schrödinger operators. Among others, we prove that Anderson orthogonality does occur for Fermi energies in the region of complete localisation with a non-zero probability. This partially confirms recent non-rigorous findings [V. Khemani et al., Nature Phys. 11 (2015), 560–565]. The spectral shift function plays an important role in our analysis of Anderson orthogonality. We identify it with the index of the corresponding pair of spectral projections and explore the consequences thereof. All our results rely on the main technical estimate of this paper which guarantees separate exponential decay of the disorder-averaged Schatten p-norm of χa(f(H)−f(Hτ))χb in a and b. Here, Hτ is a perturbation of the random Schrödinger operator H, χa is the multiplication operator corresponding to the indicator function of a unit cube centred about a∈Rd, and f is in a suitable class of functions of bounded variation with distributional derivative supported in the region of complete localisation for H.","lang":"eng"}],"type":"journal_article","publisher":"European Mathematical Society","scopus_import":"1","author":[{"id":"317CB464-F248-11E8-B48F-1D18A9856A87","first_name":"Adrian M","last_name":"Dietlein","full_name":"Dietlein, Adrian M"},{"last_name":"Gebert","full_name":"Gebert, Martin","first_name":"Martin"},{"last_name":"Müller","full_name":"Müller, Peter","first_name":"Peter"}],"publication_identifier":{"issn":["1664-039X"]},"department":[{"_id":"LaEr"}],"publication_status":"published","oa":1,"issue":"3","doi":"10.4171/jst/267","oa_version":"Preprint","quality_controlled":"1","acknowledgement":"M.G. was supported by the DFG under grant GE 2871/1-1.","month":"03","volume":9,"_id":"10879","intvolume":"         9","article_type":"original","year":"2019","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Dietlein, Adrian M., et al. “Perturbations of Continuum Random Schrödinger Operators with Applications to Anderson Orthogonality and the Spectral Shift Function.” <i>Journal of Spectral Theory</i>, vol. 9, no. 3, European Mathematical Society, 2019, pp. 921–65, doi:<a href=\"https://doi.org/10.4171/jst/267\">10.4171/jst/267</a>.","apa":"Dietlein, A. M., Gebert, M., &#38; Müller, P. (2019). Perturbations of continuum random Schrödinger operators with applications to Anderson orthogonality and the spectral shift function. <i>Journal of Spectral Theory</i>. European Mathematical Society. <a href=\"https://doi.org/10.4171/jst/267\">https://doi.org/10.4171/jst/267</a>","short":"A.M. Dietlein, M. Gebert, P. Müller, Journal of Spectral Theory 9 (2019) 921–965.","ieee":"A. M. Dietlein, M. Gebert, and P. Müller, “Perturbations of continuum random Schrödinger operators with applications to Anderson orthogonality and the spectral shift function,” <i>Journal of Spectral Theory</i>, vol. 9, no. 3. European Mathematical Society, pp. 921–965, 2019.","chicago":"Dietlein, Adrian M, Martin Gebert, and Peter Müller. “Perturbations of Continuum Random Schrödinger Operators with Applications to Anderson Orthogonality and the Spectral Shift Function.” <i>Journal of Spectral Theory</i>. European Mathematical Society, 2019. <a href=\"https://doi.org/10.4171/jst/267\">https://doi.org/10.4171/jst/267</a>.","ama":"Dietlein AM, Gebert M, Müller P. Perturbations of continuum random Schrödinger operators with applications to Anderson orthogonality and the spectral shift function. <i>Journal of Spectral Theory</i>. 2019;9(3):921-965. doi:<a href=\"https://doi.org/10.4171/jst/267\">10.4171/jst/267</a>","ista":"Dietlein AM, Gebert M, Müller P. 2019. Perturbations of continuum random Schrödinger operators with applications to Anderson orthogonality and the spectral shift function. Journal of Spectral Theory. 9(3), 921–965."},"isi":1,"keyword":["Random Schrödinger operators","spectral shift function","Anderson orthogonality"],"day":"01","date_updated":"2024-12-11T11:49:15Z"},{"_id":"11059","intvolume":"        20","year":"2019","article_type":"review","citation":{"mla":"Buchwalter, Abigail, et al. “Coaching from the Sidelines: The Nuclear Periphery in Genome Regulation.” <i>Nature Reviews Genetics</i>, vol. 20, no. 1, Springer Nature, 2019, pp. 39–50, doi:<a href=\"https://doi.org/10.1038/s41576-018-0063-5\">10.1038/s41576-018-0063-5</a>.","apa":"Buchwalter, A., Kaneshiro, J. M., &#38; Hetzer, M. (2019). Coaching from the sidelines: The nuclear periphery in genome regulation. <i>Nature Reviews Genetics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41576-018-0063-5\">https://doi.org/10.1038/s41576-018-0063-5</a>","short":"A. Buchwalter, J.M. Kaneshiro, M. Hetzer, Nature Reviews Genetics 20 (2019) 39–50.","chicago":"Buchwalter, Abigail, Jeanae M. Kaneshiro, and Martin Hetzer. “Coaching from the Sidelines: The Nuclear Periphery in Genome Regulation.” <i>Nature Reviews Genetics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41576-018-0063-5\">https://doi.org/10.1038/s41576-018-0063-5</a>.","ista":"Buchwalter A, Kaneshiro JM, Hetzer M. 2019. Coaching from the sidelines: The nuclear periphery in genome regulation. Nature Reviews Genetics. 20(1), 39–50.","ieee":"A. Buchwalter, J. M. Kaneshiro, and M. Hetzer, “Coaching from the sidelines: The nuclear periphery in genome regulation,” <i>Nature Reviews Genetics</i>, vol. 20, no. 1. Springer Nature, pp. 39–50, 2019.","ama":"Buchwalter A, Kaneshiro JM, Hetzer M. Coaching from the sidelines: The nuclear periphery in genome regulation. <i>Nature Reviews Genetics</i>. 2019;20(1):39-50. doi:<a href=\"https://doi.org/10.1038/s41576-018-0063-5\">10.1038/s41576-018-0063-5</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-10-14T11:18:54Z","day":"01","keyword":["Genetics (clinical)","Genetics","Molecular Biology"],"issue":"1","doi":"10.1038/s41576-018-0063-5","quality_controlled":"1","oa_version":"None","month":"01","volume":20,"external_id":{"pmid":["30356165"]},"extern":"1","scopus_import":"1","publisher":"Springer Nature","type":"journal_article","date_published":"2019-01-01T00:00:00Z","abstract":[{"text":"The genome is packaged and organized nonrandomly within the 3D space of the nucleus to promote efficient gene expression and to faithfully maintain silencing of heterochromatin. The genome is enclosed within the nucleus by the nuclear envelope membrane, which contains a set of proteins that actively participate in chromatin organization and gene regulation. Technological advances are providing views of genome organization at unprecedented resolution and are beginning to reveal the ways that cells co-opt the structures of the nuclear periphery for nuclear organization and gene regulation. These genome regulatory roles of proteins of the nuclear periphery have important influences on development, disease and ageing.","lang":"eng"}],"author":[{"first_name":"Abigail","last_name":"Buchwalter","full_name":"Buchwalter, Abigail"},{"first_name":"Jeanae M.","last_name":"Kaneshiro","full_name":"Kaneshiro, Jeanae M."},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W"}],"publication_status":"published","publication_identifier":{"issn":["1471-0056"],"eissn":["1471-0064"]},"pmid":1,"status":"public","date_created":"2022-04-07T07:44:45Z","article_processing_charge":"No","page":"39-50","title":"Coaching from the sidelines: The nuclear periphery in genome regulation","publication":"Nature Reviews Genetics","language":[{"iso":"eng"}]},{"intvolume":"         8","_id":"11060","year":"2019","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, M. Hetzer, ELife 8 (2019).","ista":"Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. 2019. Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. eLife. 8, e49796.","chicago":"Buchwalter, Abigail, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, and Martin Hetzer. “Selective Clearance of the Inner Nuclear Membrane Protein Emerin by Vesicular Transport during ER Stress.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/elife.49796\">https://doi.org/10.7554/elife.49796</a>.","ieee":"A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, and M. Hetzer, “Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","ama":"Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/elife.49796\">10.7554/elife.49796</a>","mla":"Buchwalter, Abigail, et al. “Selective Clearance of the Inner Nuclear Membrane Protein Emerin by Vesicular Transport during ER Stress.” <i>ELife</i>, vol. 8, e49796, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/elife.49796\">10.7554/elife.49796</a>.","apa":"Buchwalter, A., Schulte, R., Tsai, H., Capitanio, J., &#38; Hetzer, M. (2019). Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/elife.49796\">https://doi.org/10.7554/elife.49796</a>"},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"day":"10","date_updated":"2024-10-14T12:08:36Z","keyword":["General Immunology and Microbiology","General Biochemistry","Genetics and Molecular Biology","General Medicine","General Neuroscience"],"has_accepted_license":"1","quality_controlled":"1","oa_version":"Published Version","doi":"10.7554/elife.49796","volume":8,"month":"10","file":[{"success":1,"checksum":"1e8672a1e9c3dc0a2d3d0dad89673616","content_type":"application/pdf","creator":"dernst","date_updated":"2022-04-08T08:18:01Z","relation":"main_file","date_created":"2022-04-08T08:18:01Z","access_level":"open_access","file_size":6984654,"file_id":"11138","file_name":"2019_eLife_Buchwalter.pdf"}],"article_number":"e49796","external_id":{"pmid":["31599721"]},"publisher":"eLife Sciences Publications","extern":"1","scopus_import":"1","date_published":"2019-10-10T00:00:00Z","type":"journal_article","abstract":[{"text":"The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian cells. We applied dynamic proteomics to profile protein half-lives and report that INM and ER residents turn over at similar rates, indicating that the INM’s unique topology is not a barrier to turnover. Using a microscopy approach, we observed that the proteasome can degrade INM proteins in situ. However, we also uncovered evidence for selective, vesicular transport-mediated turnover of a single INM protein, emerin, that is potentiated by ER stress. Emerin is rapidly cleared from the INM by a mechanism that requires emerin’s LEM domain to mediate vesicular trafficking to lysosomes. This work demonstrates that the INM can be dynamically remodeled in response to environmental inputs.","lang":"eng"}],"ddc":["570"],"oa":1,"related_material":{"record":[{"id":"13079","status":"public","relation":"research_data"}]},"file_date_updated":"2022-04-08T08:18:01Z","publication_identifier":{"issn":["2050-084X"]},"publication_status":"published","author":[{"first_name":"Abigail","full_name":"Buchwalter, Abigail","last_name":"Buchwalter"},{"last_name":"Schulte","full_name":"Schulte, Roberta","first_name":"Roberta"},{"first_name":"Hsiao","full_name":"Tsai, Hsiao","last_name":"Tsai"},{"first_name":"Juliana","last_name":"Capitanio","full_name":"Capitanio, Juliana"},{"full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W"}],"status":"public","pmid":1,"date_created":"2022-04-07T07:45:02Z","article_processing_charge":"No","publication":"eLife","title":"Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress","language":[{"iso":"eng"}]},{"language":[{"iso":"eng"}],"publication":"Journal of Cell Biology","title":"Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells","page":"433-444","status":"public","pmid":1,"article_processing_charge":"No","date_created":"2022-04-07T07:45:11Z","oa":1,"file_date_updated":"2022-04-08T08:26:32Z","publication_status":"published","publication_identifier":{"issn":["0021-9525"],"eissn":["1540-8140"]},"author":[{"last_name":"Toyama","full_name":"Toyama, Brandon H.","first_name":"Brandon H."},{"first_name":"Rafael","full_name":"Arrojo e Drigo, Rafael","last_name":"Arrojo e Drigo"},{"last_name":"Lev-Ram","full_name":"Lev-Ram, Varda","first_name":"Varda"},{"first_name":"Ranjan","full_name":"Ramachandra, Ranjan","last_name":"Ramachandra"},{"first_name":"Thomas J.","last_name":"Deerinck","full_name":"Deerinck, Thomas J."},{"first_name":"Claude","last_name":"Lechene","full_name":"Lechene, Claude"},{"first_name":"Mark H.","full_name":"Ellisman, Mark H.","last_name":"Ellisman"},{"full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER","first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"scopus_import":"1","extern":"1","publisher":"Rockefeller University Press","type":"journal_article","abstract":[{"lang":"eng","text":"Many adult tissues contain postmitotic cells as old as the host organism. The only organelle that does not turn over in these cells is the nucleus, and its maintenance represents a formidable challenge, as it harbors regulatory proteins that persist throughout adulthood. Here we developed strategies to visualize two classes of such long-lived proteins, histones and nucleoporins, to understand the function of protein longevity in nuclear maintenance. Genome-wide mapping of histones revealed specific enrichment of long-lived variants at silent gene loci. Interestingly, nuclear pores are maintained by piecemeal replacement of subunits, resulting in mosaic complexes composed of polypeptides with vastly different ages. In contrast, nondividing quiescent cells remove old nuclear pores in an ESCRT-dependent manner. Our findings reveal distinct molecular strategies of nuclear maintenance, linking lifelong protein persistence to gene regulation and nuclear integrity."}],"date_published":"2019-02-04T00:00:00Z","ddc":["570"],"file":[{"checksum":"7964ebbf833b0b35f9fba840eea9531d","success":1,"content_type":"application/pdf","creator":"dernst","date_updated":"2022-04-08T08:26:32Z","relation":"main_file","date_created":"2022-04-08T08:26:32Z","file_id":"11139","file_name":"2019_JCB_Toyama.pdf","file_size":2503838,"access_level":"open_access"}],"external_id":{"pmid":["30552100"]},"volume":218,"month":"02","quality_controlled":"1","oa_version":"Published Version","doi":"10.1083/jcb.201809123","issue":"2","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png"},"day":"04","date_updated":"2024-10-14T11:19:21Z","keyword":["Cell Biology"],"citation":{"short":"B.H. Toyama, R. Arrojo e Drigo, V. Lev-Ram, R. Ramachandra, T.J. Deerinck, C. Lechene, M.H. Ellisman, M. Hetzer, Journal of Cell Biology 218 (2019) 433–444.","ieee":"B. H. Toyama <i>et al.</i>, “Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells,” <i>Journal of Cell Biology</i>, vol. 218, no. 2. Rockefeller University Press, pp. 433–444, 2019.","chicago":"Toyama, Brandon H., Rafael Arrojo e Drigo, Varda Lev-Ram, Ranjan Ramachandra, Thomas J. Deerinck, Claude Lechene, Mark H. Ellisman, and Martin Hetzer. “Visualization of Long-Lived Proteins Reveals Age Mosaicism within Nuclei of Postmitotic Cells.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 2019. <a href=\"https://doi.org/10.1083/jcb.201809123\">https://doi.org/10.1083/jcb.201809123</a>.","ista":"Toyama BH, Arrojo e Drigo R, Lev-Ram V, Ramachandra R, Deerinck TJ, Lechene C, Ellisman MH, Hetzer M. 2019. Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. Journal of Cell Biology. 218(2), 433–444.","ama":"Toyama BH, Arrojo e Drigo R, Lev-Ram V, et al. Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. <i>Journal of Cell Biology</i>. 2019;218(2):433-444. doi:<a href=\"https://doi.org/10.1083/jcb.201809123\">10.1083/jcb.201809123</a>","mla":"Toyama, Brandon H., et al. “Visualization of Long-Lived Proteins Reveals Age Mosaicism within Nuclei of Postmitotic Cells.” <i>Journal of Cell Biology</i>, vol. 218, no. 2, Rockefeller University Press, 2019, pp. 433–44, doi:<a href=\"https://doi.org/10.1083/jcb.201809123\">10.1083/jcb.201809123</a>.","apa":"Toyama, B. H., Arrojo e Drigo, R., Lev-Ram, V., Ramachandra, R., Deerinck, T. J., Lechene, C., … Hetzer, M. (2019). Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.201809123\">https://doi.org/10.1083/jcb.201809123</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2019","article_type":"original","intvolume":"       218","_id":"11061"},{"page":"343-351.e3","date_created":"2022-04-07T07:45:21Z","article_processing_charge":"No","pmid":1,"status":"public","publication":"Cell Metabolism","title":"Age mosaicism across multiple scales in adult tissues","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cmet.2019.05.010"}],"external_id":{"pmid":["31178361"]},"date_published":"2019-08-06T00:00:00Z","abstract":[{"lang":"eng","text":"Most neurons are not replaced during an animal’s lifetime. This nondividing state is characterized by extreme longevity and age-dependent decline of key regulatory proteins. To study the lifespans of cells and proteins in adult tissues, we combined isotope labeling of mice with a hybrid imaging method (MIMS-EM). Using 15N mapping, we show that liver and pancreas are composed of cells with vastly different ages, many as old as the animal. Strikingly, we also found that a subset of fibroblasts and endothelial cells, both known for their replicative potential, are characterized by the absence of cell division during adulthood. In addition, we show that the primary cilia of beta cells and neurons contains different structural regions with vastly different lifespans. Based on these results, we propose that age mosaicism across multiple scales is a fundamental principle of adult tissue, cell, and protein complex organization."}],"type":"journal_article","scopus_import":"1","publisher":"Elsevier","extern":"1","publication_identifier":{"issn":["1550-4131"]},"department":[{"_id":"MaHe"}],"publication_status":"published","oa":1,"author":[{"last_name":"Arrojo e Drigo","full_name":"Arrojo e Drigo, Rafael","first_name":"Rafael"},{"full_name":"Lev-Ram, Varda","last_name":"Lev-Ram","first_name":"Varda"},{"first_name":"Swati","full_name":"Tyagi, Swati","last_name":"Tyagi"},{"full_name":"Ramachandra, Ranjan","last_name":"Ramachandra","first_name":"Ranjan"},{"first_name":"Thomas","last_name":"Deerinck","full_name":"Deerinck, Thomas"},{"first_name":"Eric","full_name":"Bushong, Eric","last_name":"Bushong"},{"full_name":"Phan, Sebastien","last_name":"Phan","first_name":"Sebastien"},{"full_name":"Orphan, Victoria","last_name":"Orphan","first_name":"Victoria"},{"full_name":"Lechene, Claude","last_name":"Lechene","first_name":"Claude"},{"last_name":"Ellisman","full_name":"Ellisman, Mark H.","first_name":"Mark H."},{"first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER"}],"issue":"2","oa_version":"Published Version","quality_controlled":"1","doi":"10.1016/j.cmet.2019.05.010","volume":30,"month":"08","intvolume":"        30","_id":"11062","article_type":"original","year":"2019","citation":{"short":"R. Arrojo e Drigo, V. Lev-Ram, S. Tyagi, R. Ramachandra, T. Deerinck, E. Bushong, S. Phan, V. Orphan, C. Lechene, M.H. Ellisman, M. Hetzer, Cell Metabolism 30 (2019) 343–351.e3.","chicago":"Arrojo e Drigo, Rafael, Varda Lev-Ram, Swati Tyagi, Ranjan Ramachandra, Thomas Deerinck, Eric Bushong, Sebastien Phan, et al. “Age Mosaicism across Multiple Scales in Adult Tissues.” <i>Cell Metabolism</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.cmet.2019.05.010\">https://doi.org/10.1016/j.cmet.2019.05.010</a>.","ista":"Arrojo e Drigo R, Lev-Ram V, Tyagi S, Ramachandra R, Deerinck T, Bushong E, Phan S, Orphan V, Lechene C, Ellisman MH, Hetzer M. 2019. Age mosaicism across multiple scales in adult tissues. Cell Metabolism. 30(2), 343–351.e3.","ieee":"R. Arrojo e Drigo <i>et al.</i>, “Age mosaicism across multiple scales in adult tissues,” <i>Cell Metabolism</i>, vol. 30, no. 2. Elsevier, p. 343–351.e3, 2019.","ama":"Arrojo e Drigo R, Lev-Ram V, Tyagi S, et al. Age mosaicism across multiple scales in adult tissues. <i>Cell Metabolism</i>. 2019;30(2):343-351.e3. doi:<a href=\"https://doi.org/10.1016/j.cmet.2019.05.010\">10.1016/j.cmet.2019.05.010</a>","mla":"Arrojo e Drigo, Rafael, et al. “Age Mosaicism across Multiple Scales in Adult Tissues.” <i>Cell Metabolism</i>, vol. 30, no. 2, Elsevier, 2019, p. 343–351.e3, doi:<a href=\"https://doi.org/10.1016/j.cmet.2019.05.010\">10.1016/j.cmet.2019.05.010</a>.","apa":"Arrojo e Drigo, R., Lev-Ram, V., Tyagi, S., Ramachandra, R., Deerinck, T., Bushong, E., … Hetzer, M. (2019). Age mosaicism across multiple scales in adult tissues. <i>Cell Metabolism</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cmet.2019.05.010\">https://doi.org/10.1016/j.cmet.2019.05.010</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","keyword":["Cell Biology","Molecular Biology","Physiology"],"day":"06","date_updated":"2025-12-15T10:02:11Z"},{"volume":3,"month":"10","acknowledgement":"The authors would also like to thank anonymous referees for their valuable comments and helpful suggestions. This work is supported by the Austrian Science Fund (FWF) NFN grants S11407-N23 (RiSE/SHiNE) and S11402-N23 (RiSE/SHiNE), by the Vienna Science and Technology Fund (WWTF) Project ICT15-003, and by the Austrian Science Fund (FWF) Schrodinger grant J-4220.\r\n","oa_version":"Published Version","quality_controlled":"1","doi":"10.1145/3360550","has_accepted_license":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["safety","risk","reliability and quality","software"],"day":"10","date_updated":"2025-05-20T09:38:25Z","citation":{"ista":"Chatterjee K, Pavlogiannis A, Toman V. 2019. Value-centric dynamic partial order reduction. Proceedings of the 34th ACM International Conference on Object-Oriented Programming, Systems, Languages, and Applications. OOPSLA: Object-oriented Programming, Systems, Languages and Applications vol. 3, 124.","ama":"Chatterjee K, Pavlogiannis A, Toman V. Value-centric dynamic partial order reduction. In: <i>Proceedings of the 34th ACM International Conference on Object-Oriented Programming, Systems, Languages, and Applications</i>. Vol 3. ACM; 2019. doi:<a href=\"https://doi.org/10.1145/3360550\">10.1145/3360550</a>","chicago":"Chatterjee, Krishnendu, Andreas Pavlogiannis, and Viktor Toman. “Value-Centric Dynamic Partial Order Reduction.” In <i>Proceedings of the 34th ACM International Conference on Object-Oriented Programming, Systems, Languages, and Applications</i>, Vol. 3. ACM, 2019. <a href=\"https://doi.org/10.1145/3360550\">https://doi.org/10.1145/3360550</a>.","ieee":"K. Chatterjee, A. Pavlogiannis, and V. Toman, “Value-centric dynamic partial order reduction,” in <i>Proceedings of the 34th ACM International Conference on Object-Oriented Programming, Systems, Languages, and Applications</i>, Athens, Greece, 2019, vol. 3.","short":"K. Chatterjee, A. Pavlogiannis, V. Toman, in:, Proceedings of the 34th ACM International Conference on Object-Oriented Programming, Systems, Languages, and Applications, ACM, 2019.","apa":"Chatterjee, K., Pavlogiannis, A., &#38; Toman, V. (2019). Value-centric dynamic partial order reduction. In <i>Proceedings of the 34th ACM International Conference on Object-Oriented Programming, Systems, Languages, and Applications</i> (Vol. 3). Athens, Greece: ACM. <a href=\"https://doi.org/10.1145/3360550\">https://doi.org/10.1145/3360550</a>","mla":"Chatterjee, Krishnendu, et al. “Value-Centric Dynamic Partial Order Reduction.” <i>Proceedings of the 34th ACM International Conference on Object-Oriented Programming, Systems, Languages, and Applications</i>, vol. 3, 124, ACM, 2019, doi:<a href=\"https://doi.org/10.1145/3360550\">10.1145/3360550</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2019","intvolume":"         3","_id":"10190","OA_place":"publisher","language":[{"iso":"eng"}],"corr_author":"1","arxiv":1,"conference":{"name":"OOPSLA: Object-oriented Programming, Systems, Languages and Applications","start_date":"2019-10-23","end_date":"2019-10-25","location":"Athens, Greece"},"publication":"Proceedings of the 34th ACM International Conference on Object-Oriented Programming, Systems, Languages, and Applications","title":"Value-centric dynamic partial order reduction","article_processing_charge":"No","date_created":"2021-10-27T14:57:06Z","status":"public","publication_identifier":{"eissn":["2475-1421"]},"department":[{"_id":"GradSch"},{"_id":"KrCh"}],"publication_status":"published","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"10199"}]},"oa":1,"file_date_updated":"2021-11-12T11:41:56Z","author":[{"orcid":"0000-0002-4561-241X","last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu"},{"last_name":"Pavlogiannis","orcid":"0000-0002-8943-0722","full_name":"Pavlogiannis, Andreas","id":"49704004-F248-11E8-B48F-1D18A9856A87","first_name":"Andreas"},{"id":"3AF3DA7C-F248-11E8-B48F-1D18A9856A87","first_name":"Viktor","full_name":"Toman, Viktor","last_name":"Toman","orcid":"0000-0001-9036-063X"}],"abstract":[{"text":"The verification of concurrent programs remains an open challenge, as thread interaction has to be accounted for, which leads to state-space explosion. Stateless model checking battles this problem by exploring traces rather than states of the program. As there are exponentially many traces, dynamic partial-order reduction (DPOR) techniques are used to partition the trace space into equivalence classes, and explore a few representatives from each class. The standard equivalence that underlies most DPOR techniques is the happens-before equivalence, however recent works have spawned a vivid interest towards coarser equivalences. The efficiency of such approaches is a product of two parameters: (i) the size of the partitioning induced by the equivalence, and (ii) the time spent by the exploration algorithm in each class of the partitioning. In this work, we present a new equivalence, called value-happens-before and show that it has two appealing features. First, value-happens-before is always at least as coarse as the happens-before equivalence, and can be even exponentially coarser. Second, the value-happens-before partitioning is efficiently explorable when the number of threads is bounded. We present an algorithm called value-centric DPOR (VCDPOR), which explores the underlying partitioning using polynomial time per class. Finally, we perform an experimental evaluation of VCDPOR on various benchmarks, and compare it against other state-of-the-art approaches. Our results show that value-happens-before typically induces a significant reduction in the size of the underlying partitioning, which leads to a considerable reduction in the running time for exploring the whole partitioning.","lang":"eng"}],"type":"conference","date_published":"2019-10-10T00:00:00Z","publisher":"ACM","scopus_import":"1","OA_type":"hybrid","ddc":["000"],"file":[{"creator":"cchlebak","date_updated":"2021-11-12T11:41:56Z","checksum":"2149979c46964c4d117af06ccb6c0834","success":1,"content_type":"application/pdf","file_name":"2019_ACM_Chatterjee.pdf","file_id":"10278","access_level":"open_access","file_size":570829,"relation":"main_file","date_created":"2021-11-12T11:41:56Z"}],"article_number":"124","external_id":{"arxiv":["1909.00989"]},"project":[{"grant_number":"ICT15-003","name":"Efficient Algorithms for Computer Aided Verification","_id":"25892FC0-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","name":"Game Theory","_id":"25863FF4-B435-11E9-9278-68D0E5697425","grant_number":"S11407"},{"call_identifier":"FWF","grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering"},{"call_identifier":"FWF","_id":"25F5A88A-B435-11E9-9278-68D0E5697425","name":"Moderne Concurrency Paradigms","grant_number":"S11402-N23"}]},{"keyword":["cell biology"],"date_updated":"2021-11-26T11:54:29Z","day":"22","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","citation":{"ama":"Harker-Kirschneck L, Baum B, Šarić A. Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico. <i>BMC Biology</i>. 2019;17(1). doi:<a href=\"https://doi.org/10.1186/s12915-019-0700-2\">10.1186/s12915-019-0700-2</a>","ieee":"L. Harker-Kirschneck, B. Baum, and A. Šarić, “Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico,” <i>BMC Biology</i>, vol. 17, no. 1. Springer Nature, 2019.","chicago":"Harker-Kirschneck, Lena, Buzz Baum, and Anđela Šarić. “Changes in ESCRT-III Filament Geometry Drive Membrane Remodelling and Fission in Silico.” <i>BMC Biology</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1186/s12915-019-0700-2\">https://doi.org/10.1186/s12915-019-0700-2</a>.","ista":"Harker-Kirschneck L, Baum B, Šarić A. 2019. Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico. BMC Biology. 17(1), 82.","short":"L. Harker-Kirschneck, B. Baum, A. Šarić, BMC Biology 17 (2019).","apa":"Harker-Kirschneck, L., Baum, B., &#38; Šarić, A. (2019). Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico. <i>BMC Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s12915-019-0700-2\">https://doi.org/10.1186/s12915-019-0700-2</a>","mla":"Harker-Kirschneck, Lena, et al. “Changes in ESCRT-III Filament Geometry Drive Membrane Remodelling and Fission in Silico.” <i>BMC Biology</i>, vol. 17, no. 1, 82, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1186/s12915-019-0700-2\">10.1186/s12915-019-0700-2</a>."},"article_type":"original","year":"2019","_id":"10354","intvolume":"        17","month":"10","volume":17,"acknowledgement":"We thank Jeremy Carlton, Mike Staddon, Geraint Harker, and the Wellcome Trust Consortium “Archaeal Origins of Eukaryotic Cell Organisation” for fruitful conversations. We thank Peter Wirnsberger and Tine Curk for discussions about the membrane model implementation.","doi":"10.1186/s12915-019-0700-2","oa_version":"Published Version","quality_controlled":"1","has_accepted_license":"1","issue":"1","author":[{"first_name":"Lena","full_name":"Harker-Kirschneck, Lena","last_name":"Harker-Kirschneck"},{"last_name":"Baum","full_name":"Baum, Buzz","first_name":"Buzz"},{"last_name":"Šarić","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela","first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"}],"publication_identifier":{"issn":["1741-7007"]},"publication_status":"published","oa":1,"file_date_updated":"2021-11-26T11:37:54Z","ddc":["570"],"abstract":[{"text":"Background\r\nESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane repair. Distinct from other cytoskeletal filaments, ESCRT-III filaments do not consume energy themselves, but work in conjunction with another ATP-consuming complex. Despite rapid progress in describing the cell biology of ESCRT-III, we lack an understanding of the physical mechanisms behind its force production and membrane remodelling.\r\nResults\r\nHere we present a minimal coarse-grained model that captures all the experimentally reported cases of ESCRT-III driven membrane sculpting, including the formation of downward and upward cones and tubules. This model suggests that a change in the geometry of membrane bound ESCRT-III filaments—from a flat spiral to a 3D helix—drives membrane deformation. We then show that such repetitive filament geometry transitions can induce the fission of cargo-containing vesicles.\r\nConclusions\r\nOur model provides a general physical mechanism that explains the full range of ESCRT-III-dependent membrane remodelling and scission events observed in cells. This mechanism for filament force production is distinct from the mechanisms described for other cytoskeletal elements discovered so far. The mechanistic principles revealed here suggest new ways of manipulating ESCRT-III-driven processes in cells and could be used to guide the engineering of synthetic membrane-sculpting systems.","lang":"eng"}],"date_published":"2019-10-22T00:00:00Z","type":"journal_article","extern":"1","publisher":"Springer Nature","scopus_import":"1","article_number":"82","external_id":{"pmid":["31640700"]},"main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/559898"}],"file":[{"success":1,"checksum":"31d8bae55a376d30925f53f7e1a02396","content_type":"application/pdf","creator":"cchlebak","date_updated":"2021-11-26T11:37:54Z","relation":"main_file","date_created":"2021-11-26T11:37:54Z","file_id":"10356","file_name":"2019_BMCBio_Harker_Kirschneck.pdf","file_size":1648926,"access_level":"open_access"}],"language":[{"iso":"eng"}],"title":"Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico","publication":"BMC Biology","date_created":"2021-11-26T11:25:03Z","article_processing_charge":"No","pmid":1,"status":"public"},{"doi":"10.1016/j.sbi.2019.05.018","oa_version":"Preprint","quality_controlled":"1","month":"06","volume":58,"acknowledgement":"We acknowledge funding from EPSRC (A.E.H. and A.Š.), the Academy of Medical Sciences (J.K. and A.Š.), the Wellcome Trust (J.K. and A.Š.), and the Royal Society (A.Š.). We thank Shiladitya Banerjee and Nikola Ojkic for critically reading the manuscript, and Claudia Flandoli for helping us with figures and illustrations.","year":"2019","article_type":"original","_id":"10355","intvolume":"        58","keyword":["molecular biology","structural biology"],"date_updated":"2021-11-26T11:54:25Z","day":"18","citation":{"apa":"Hafner, A. E., Krausser, J., &#38; Šarić, A. (2019). Minimal coarse-grained models for molecular self-organisation in biology. <i>Current Opinion in Structural Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.sbi.2019.05.018\">https://doi.org/10.1016/j.sbi.2019.05.018</a>","mla":"Hafner, Anne E., et al. “Minimal Coarse-Grained Models for Molecular Self-Organisation in Biology.” <i>Current Opinion in Structural Biology</i>, vol. 58, Elsevier, 2019, pp. 43–52, doi:<a href=\"https://doi.org/10.1016/j.sbi.2019.05.018\">10.1016/j.sbi.2019.05.018</a>.","ama":"Hafner AE, Krausser J, Šarić A. Minimal coarse-grained models for molecular self-organisation in biology. <i>Current Opinion in Structural Biology</i>. 2019;58:43-52. doi:<a href=\"https://doi.org/10.1016/j.sbi.2019.05.018\">10.1016/j.sbi.2019.05.018</a>","ieee":"A. E. Hafner, J. Krausser, and A. Šarić, “Minimal coarse-grained models for molecular self-organisation in biology,” <i>Current Opinion in Structural Biology</i>, vol. 58. Elsevier, pp. 43–52, 2019.","ista":"Hafner AE, Krausser J, Šarić A. 2019. Minimal coarse-grained models for molecular self-organisation in biology. Current Opinion in Structural Biology. 58, 43–52.","chicago":"Hafner, Anne E, Johannes Krausser, and Anđela Šarić. “Minimal Coarse-Grained Models for Molecular Self-Organisation in Biology.” <i>Current Opinion in Structural Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.sbi.2019.05.018\">https://doi.org/10.1016/j.sbi.2019.05.018</a>.","short":"A.E. Hafner, J. Krausser, A. Šarić, Current Opinion in Structural Biology 58 (2019) 43–52."},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","title":"Minimal coarse-grained models for molecular self-organisation in biology","publication":"Current Opinion in Structural Biology","date_created":"2021-11-26T11:33:21Z","article_processing_charge":"No","pmid":1,"status":"public","page":"43-52","language":[{"iso":"eng"}],"external_id":{"pmid":["31226513"]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1906.09349"}],"author":[{"first_name":"Anne E","full_name":"Hafner, Anne E","last_name":"Hafner"},{"first_name":"Johannes","last_name":"Krausser","full_name":"Krausser, Johannes"},{"last_name":"Šarić","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela","first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"}],"publication_identifier":{"issn":["0959-440X"]},"publication_status":"published","oa":1,"type":"journal_article","date_published":"2019-06-18T00:00:00Z","abstract":[{"text":"The molecular machinery of life is largely created via self-organisation of individual molecules into functional assemblies. Minimal coarse-grained models, in which a whole macromolecule is represented by a small number of particles, can be of great value in identifying the main driving forces behind self-organisation in cell biology. Such models can incorporate data from both molecular and continuum scales, and their results can be directly compared to experiments. Here we review the state of the art of models for studying the formation and biological function of macromolecular assemblies in living organisms. We outline the key ingredients of each model and their main findings. We illustrate the contribution of this class of simulations to identifying the physical mechanisms behind life and diseases, and discuss their future developments.","lang":"eng"}],"scopus_import":"1","extern":"1","publisher":"Elsevier"},{"month":"01","volume":27,"acknowledgement":"This work was supported by EuroGentest2 (Unit 2: “Genetic testing as part of health care”), a Coordination Action under FP7 (Grant Agreement Number 261469) and the European Society of Human Genetics. We acknowledge the participation of the patients and their families in these studies, as well as the generous financial support of the Lefroy and Handbury families. APLM was supported by an Australian Postgraduate Award. PJL is supported by an NHMRC Career Development Fellowship (GNT1032364). RJL is supported by a Melbourne Children’s Clinician Scientist Fellowship.","doi":"10.1038/s41431-018-0231-2","oa_version":"Published Version","quality_controlled":"1","isi":1,"day":"01","date_updated":"2023-08-24T14:28:24Z","citation":{"chicago":"Marsh, Ashley, Gaia Novarino, Paul Lockhart, and Richard Leventer. “CUGC for Pontocerebellar Hypoplasia Type 9 and Spastic Paraplegia-63.” <i>European Journal of Human Genetics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41431-018-0231-2\">https://doi.org/10.1038/s41431-018-0231-2</a>.","ama":"Marsh A, Novarino G, Lockhart P, Leventer R. CUGC for pontocerebellar hypoplasia type 9 and spastic paraplegia-63. <i>European Journal of Human Genetics</i>. 2019;27:161-166. doi:<a href=\"https://doi.org/10.1038/s41431-018-0231-2\">10.1038/s41431-018-0231-2</a>","ista":"Marsh A, Novarino G, Lockhart P, Leventer R. 2019. CUGC for pontocerebellar hypoplasia type 9 and spastic paraplegia-63. European Journal of Human Genetics. 27, 161–166.","ieee":"A. Marsh, G. Novarino, P. Lockhart, and R. Leventer, “CUGC for pontocerebellar hypoplasia type 9 and spastic paraplegia-63,” <i>European Journal of Human Genetics</i>, vol. 27. Springer Nature, pp. 161–166, 2019.","short":"A. Marsh, G. Novarino, P. Lockhart, R. Leventer, European Journal of Human Genetics 27 (2019) 161–166.","apa":"Marsh, A., Novarino, G., Lockhart, P., &#38; Leventer, R. (2019). CUGC for pontocerebellar hypoplasia type 9 and spastic paraplegia-63. <i>European Journal of Human Genetics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41431-018-0231-2\">https://doi.org/10.1038/s41431-018-0231-2</a>","mla":"Marsh, Ashley, et al. “CUGC for Pontocerebellar Hypoplasia Type 9 and Spastic Paraplegia-63.” <i>European Journal of Human Genetics</i>, vol. 27, Springer Nature, 2019, pp. 161–66, doi:<a href=\"https://doi.org/10.1038/s41431-018-0231-2\">10.1038/s41431-018-0231-2</a>."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_type":"original","year":"2019","_id":"105","intvolume":"        27","publist_id":"7949","language":[{"iso":"eng"}],"title":"CUGC for pontocerebellar hypoplasia type 9 and spastic paraplegia-63","publication":"European Journal of Human Genetics","article_processing_charge":"No","date_created":"2018-12-11T11:44:39Z","status":"public","pmid":1,"page":"161-166","author":[{"first_name":"Ashley","full_name":"Marsh, Ashley","last_name":"Marsh"},{"full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia"},{"first_name":"Paul","full_name":"Lockhart, Paul","last_name":"Lockhart"},{"first_name":"Richard","full_name":"Leventer, Richard","last_name":"Leventer"}],"department":[{"_id":"GaNo"}],"publication_status":"published","oa":1,"abstract":[{"lang":"eng","text":"Clinical Utility Gene Card. 1. Name of Disease (Synonyms): Pontocerebellar hypoplasia type 9 (PCH9) and spastic paraplegia-63 (SPG63). 2. OMIM# of the Disease: 615809 and 615686. 3. Name of the Analysed Genes or DNA/Chromosome Segments: AMPD2 at 1p13.3. 4. OMIM# of the Gene(s): 102771."}],"date_published":"2019-01-01T00:00:00Z","type":"journal_article","scopus_import":"1","publisher":"Springer Nature","external_id":{"isi":["000454111500019"],"pmid":["30089829"]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41431-018-0231-2"}]},{"volume":47,"month":"06","quality_controlled":"1","oa_version":"Published Version","doi":"10.1093/nar/gkz352","issue":"11","has_accepted_license":"1","tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"day":"20","date_updated":"2026-02-23T09:56:28Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"V. Corvaglia, D. Carbajo, P. Prabhakaran, K. Ziach, P.K. Mandal, V.D. Santos, C. Legeay, R. Vogel, V. Parissi, P. Pourquier, I. Huc, Nucleic Acids Research 47 (2019) 5511–5521.","ama":"Corvaglia V, Carbajo D, Prabhakaran P, et al. Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins. <i>Nucleic Acids Research</i>. 2019;47(11):5511-5521. doi:<a href=\"https://doi.org/10.1093/nar/gkz352\">10.1093/nar/gkz352</a>","ieee":"V. Corvaglia <i>et al.</i>, “Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins,” <i>Nucleic Acids Research</i>, vol. 47, no. 11. Oxford University Press, pp. 5511–5521, 2019.","ista":"Corvaglia V, Carbajo D, Prabhakaran P, Ziach K, Mandal PK, Santos VD, Legeay C, Vogel R, Parissi V, Pourquier P, Huc I. 2019. Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins. Nucleic Acids Research. 47(11), 5511–5521.","chicago":"Corvaglia, Valentina, Daniel Carbajo, Panchami Prabhakaran, Krzysztof Ziach, Pradeep K Mandal, Victor Dos Santos, Carole Legeay, et al. “Carboxylate-Functionalized Foldamer Inhibitors of HIV-1 Integrase and Topoisomerase 1: Artificial Analogues of DNA Mimic Proteins.” <i>Nucleic Acids Research</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/nar/gkz352\">https://doi.org/10.1093/nar/gkz352</a>.","mla":"Corvaglia, Valentina, et al. “Carboxylate-Functionalized Foldamer Inhibitors of HIV-1 Integrase and Topoisomerase 1: Artificial Analogues of DNA Mimic Proteins.” <i>Nucleic Acids Research</i>, vol. 47, no. 11, Oxford University Press, 2019, pp. 5511–21, doi:<a href=\"https://doi.org/10.1093/nar/gkz352\">10.1093/nar/gkz352</a>.","apa":"Corvaglia, V., Carbajo, D., Prabhakaran, P., Ziach, K., Mandal, P. K., Santos, V. D., … Huc, I. (2019). Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins. <i>Nucleic Acids Research</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/nar/gkz352\">https://doi.org/10.1093/nar/gkz352</a>"},"year":"2019","article_type":"original","intvolume":"        47","_id":"21095","license":"https://creativecommons.org/licenses/by-nc/4.0/","OA_place":"publisher","language":[{"iso":"eng"}],"publication":"Nucleic Acids Research","title":"Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: Artificial analogues of DNA mimic proteins","page":"5511-5521","DOAJ_listed":"1","status":"public","date_created":"2026-01-29T21:17:15Z","article_processing_charge":"No","oa":1,"publication_status":"published","publication_identifier":{"issn":["0305-1048"],"eissn":["1362-4962"]},"author":[{"full_name":"Corvaglia, Valentina","last_name":"Corvaglia","first_name":"Valentina"},{"first_name":"Daniel","full_name":"Carbajo, Daniel","last_name":"Carbajo"},{"last_name":"Prabhakaran","full_name":"Prabhakaran, Panchami","first_name":"Panchami"},{"last_name":"Ziach","full_name":"Ziach, Krzysztof","first_name":"Krzysztof"},{"full_name":"Mandal, Pradeep K","orcid":"0000-0001-5996-956X","last_name":"Mandal","first_name":"Pradeep K","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3"},{"full_name":"Santos, Victor Dos","last_name":"Santos","first_name":"Victor Dos"},{"full_name":"Legeay, Carole","last_name":"Legeay","first_name":"Carole"},{"first_name":"Rachel","last_name":"Vogel","full_name":"Vogel, Rachel"},{"full_name":"Parissi, Vincent","last_name":"Parissi","first_name":"Vincent"},{"full_name":"Pourquier, Philippe","last_name":"Pourquier","first_name":"Philippe"},{"first_name":"Ivan","full_name":"Huc, Ivan","last_name":"Huc"}],"extern":"1","publisher":"Oxford University Press","date_published":"2019-06-20T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"Inspired by DNA mimic proteins, we have introduced aromatic foldamers bearing phosphonate groups as synthetic mimics of the charge surface of B-DNA and competitive inhibitors of some therapeutically relevant DNA-binding enzymes: the human DNA Topoisomerase 1 (Top1) and the human HIV-1 integrase (HIV-1 IN). We now report on variants of these anionic foldamers bearing carboxylates instead of phosphonates. Several new monomers have been synthesized with protecting groups suitable for solid phase synthesis (SPS). Six hexadecaamides have been prepared using SPS. Proof of their resemblance to B-DNA was brought by the first crystal structure of one of these DNA-mimic foldamers in its polyanionic form. While some of the foldamers were found to be as active as, or even more active than, the original phosphonate oligomers, others had no activity at all or could even stimulate enzyme activity in vitro. Some foldamers were found to have differential inhibitory effects on the two enzymes. These results demonstrate a strong dependence of inhibitory activity on foldamer structure and charge distribution. They open broad avenues for the development of new classes of derivatives that could inhibit the interaction of specific proteins with their DNA target thereby influencing the cellular pathways in which they are involved."}],"OA_type":"gold","main_file_link":[{"url":"https://doi.org/10.1093/nar/gkz352","open_access":"1"}]}]