[{"status":"public","intvolume":"     16318","page":"257-267","year":"2026","abstract":[{"text":"Three-dimensional (3D) microscopy data is often anisotropic with significantly lower resolution (up to 8x) along the z axis than along the xy axes. Computationally generating plausible isotropic resolution from anisotropic imaging data would benefit the visual analysis of large-scale volumes. This paper proposes niiv, a self-supervised method for isotropic reconstruction of 3D microscopy data that can quickly produce images at arbitrary output resolutions. The representation embeds a learned latent code within a neural field that describes the implicit higher-resolution isotropic image region. We use an attention-guided latent interpolation approach, which allows flexible information exchange over a local latent neighborhood. Under isotropic volume assumptions, we self-supervise this representation on low-/high-resolution lateral image pairs to reconstruct an isotropic volume from low-resolution axial images. We evaluate our method on simulated and real anisotropic electron (EM) and light microscopy (LM) data. Compared to diffusion-based baselines, niiv shows improved reconstruction quality (+1 dB PSNR) and is over three orders of magnitude faster (1,000x) to infer. Specifically, niiv reconstructs a 128^3 voxel volume in 2/10th of a second, renderable at varying (continuous) high resolutions for display. Our code is available at https://github.com/jakobtroidl/niiv-miccai.","lang":"eng"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2024.09.07.611785"}],"oa":1,"quality_controlled":"1","publisher":"Springer Nature","date_published":"2026-01-03T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","article_processing_charge":"No","date_created":"2026-02-01T23:01:44Z","publication_identifier":{"issn":["0302-9743"],"isbn":["9783032139603"],"eissn":["1611-3349"]},"department":[{"_id":"JoDa"}],"day":"03","publication_status":"published","_id":"21135","language":[{"iso":"eng"}],"related_material":{"link":[{"relation":"software","url":"https://github.com/jakobtroidl/niiv-miccai"}]},"conference":{"name":"EMA4MICCAI: Efficient Medical Artificial Intelligence","start_date":"2025-09-23","location":"Daejeon, South Korea","end_date":"2025-09-23"},"month":"01","date_updated":"2026-02-16T08:50:50Z","publication":"1st International Workshop on Efficient Medical Artificial Intelligence","alternative_title":["LNCS"],"acknowledgement":"This work was supported by NIH grants 1U01NS132158 and R01HD104969. We thank the reviewers for their constructive feedback.","doi":"10.1007/978-3-032-13961-0_26","OA_place":"repository","author":[{"full_name":"Troidl, Jakob","first_name":"Jakob","last_name":"Troidl"},{"full_name":"Liang, Yiqing","first_name":"Yiqing","last_name":"Liang"},{"last_name":"Beyer","full_name":"Beyer, Johanna","first_name":"Johanna"},{"id":"3A0A06F4-F248-11E8-B48F-1D18A9856A87","full_name":"Tavakoli, Mojtaba","first_name":"Mojtaba","last_name":"Tavakoli","orcid":"0000-0002-7667-6854"},{"full_name":"Danzl, Johann G","first_name":"Johann G","last_name":"Danzl","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973"},{"first_name":"Markus","full_name":"Hadwiger, Markus","last_name":"Hadwiger"},{"first_name":"Hanspeter","full_name":"Pfister, Hanspeter","last_name":"Pfister"},{"full_name":"Tompkin, James","first_name":"James","last_name":"Tompkin"}],"OA_type":"green","title":"niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction","citation":{"mla":"Troidl, Jakob, et al. “Niiv: Interactive Self-Supervised Neural Implicit Isotropic Volume Reconstruction.” <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>, vol. 16318, Springer Nature, 2026, pp. 257–67, doi:<a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">10.1007/978-3-032-13961-0_26</a>.","ieee":"J. Troidl <i>et al.</i>, “niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction,” in <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>, Daejeon, South Korea, 2026, vol. 16318, pp. 257–267.","ista":"Troidl J, Liang Y, Beyer J, Tavakoli M, Danzl JG, Hadwiger M, Pfister H, Tompkin J. 2026. niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction. 1st International Workshop on Efficient Medical Artificial Intelligence. EMA4MICCAI: Efficient Medical Artificial Intelligence, LNCS, vol. 16318, 257–267.","chicago":"Troidl, Jakob, Yiqing Liang, Johanna Beyer, Mojtaba Tavakoli, Johann G Danzl, Markus Hadwiger, Hanspeter Pfister, and James Tompkin. “Niiv: Interactive Self-Supervised Neural Implicit Isotropic Volume Reconstruction.” In <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>, 16318:257–67. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">https://doi.org/10.1007/978-3-032-13961-0_26</a>.","ama":"Troidl J, Liang Y, Beyer J, et al. niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction. In: <i>1st International Workshop on Efficient Medical Artificial Intelligence</i>. Vol 16318. Springer Nature; 2026:257-267. doi:<a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">10.1007/978-3-032-13961-0_26</a>","apa":"Troidl, J., Liang, Y., Beyer, J., Tavakoli, M., Danzl, J. G., Hadwiger, M., … Tompkin, J. (2026). niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction. In <i>1st International Workshop on Efficient Medical Artificial Intelligence</i> (Vol. 16318, pp. 257–267). Daejeon, South Korea: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-032-13961-0_26\">https://doi.org/10.1007/978-3-032-13961-0_26</a>","short":"J. Troidl, Y. Liang, J. Beyer, M. Tavakoli, J.G. Danzl, M. Hadwiger, H. Pfister, J. Tompkin, in:, 1st International Workshop on Efficient Medical Artificial Intelligence, Springer Nature, 2026, pp. 257–267."},"volume":16318,"type":"conference","oa_version":"Preprint"},{"publisher":"Institute of Science and Technology Austria","file":[{"file_id":"21461","content_type":"application/zip","checksum":"5d1fda7e410f24c311fcf6bcf725698f","access_level":"open_access","relation":"main_file","description":"Python3 library written in C++20 to integrate vertex models. Please read the readme at https://github.com/yketa/cells/blob/main/README.md for detailed instructions for installation and usage of the code in this repository. ","creator":"snaik","title":"Cell git repository","file_name":"cells-main.zip","date_updated":"2026-03-16T11:51:10Z","date_created":"2026-03-16T11:51:10Z","file_size":725916},{"access_level":"open_access","relation":"main_file","success":1,"checksum":"ee350c8eaed99f3ca348c47c8b190d3c","content_type":"application/x-zip-compressed","file_id":"21464","file_size":282168895,"date_updated":"2026-03-18T14:52:02Z","date_created":"2026-03-18T14:52:02Z","creator":"snaik","file_name":"DevBranchDataRepo.zip"},{"file_name":"ReadMe.md","creator":"snaik","date_created":"2026-03-18T15:01:32Z","date_updated":"2026-03-18T15:01:32Z","file_size":2231,"content_type":"text/markdown","file_id":"21466","checksum":"1ecaf2c1a2ce8ff9c75a128cc02d0b8f","success":1,"access_level":"open_access","relation":"main_file"},{"file_size":1951210,"date_updated":"2026-03-18T15:12:57Z","date_created":"2026-03-18T15:12:57Z","creator":"snaik","file_name":"PaperSchematics.svg","relation":"main_file","access_level":"open_access","success":1,"checksum":"da9a4687e5144b61a64ca341f922046a","content_type":"image/svg+xml","file_id":"21467"},{"checksum":"9ac1054b16c212c6f34d402dce2c80e0","file_id":"21468","content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","success":1,"file_name":"maxwell_sketch.tex","creator":"snaik","file_size":1897,"date_created":"2026-03-21T03:37:43Z","date_updated":"2026-03-21T03:37:43Z"},{"creator":"snaik","file_name":"DataRepo.zip","date_updated":"2026-03-24T07:21:43Z","date_created":"2026-03-24T07:21:43Z","file_size":749368723,"content_type":"application/x-zip-compressed","file_id":"21495","checksum":"7c9ecf78e2593b3830d96fa94baa08df","success":1,"relation":"main_file","access_level":"open_access"}],"oa":1,"ec_funded":1,"date_published":"2026-03-24T00:00:00Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","article_processing_charge":"No","file_date_updated":"2026-03-24T07:21:43Z","date_created":"2026-02-04T16:38:02Z","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385"},{"_id":"8f060199-16d5-11f0-9cad-f3253b266c46","name":"Keratins in epithelial tissue spreading","grant_number":"PAT 5044023"},{"name":"Nano-Analytics of Cellular Systems","_id":"252C3B08-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"W1250-B20"}],"status":"public","corr_author":"1","year":"2026","contributor":[{"last_name":"Keta","contributor_type":"researcher","first_name":"Yann-Edwin"},{"last_name":"Henkes","contributor_type":"supervisor","first_name":"Silke "},{"first_name":"Carl-Philipp J","contributor_type":"supervisor","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"},{"orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","contributor_type":"supervisor","first_name":"Edouard B"}],"doi":"10.15479/AT-ISTA-21137","license":"https://creativecommons.org/licenses/by-sa/4.0/","acknowledgement":"We thank all members of the Heisenberg, Henkes, and Hannezo groups for their support. We are also grateful to the Imaging and Optics, Scientific Computing, Life Science Support, and Cryo-Electron Microscopy facilities at ISTA for their technical assistance and support. Numerical simulations were performed using the computational resources from Lorentz Institute and the Academic Leiden Interdisciplinary Cluster Environment (ALICE) provided by Leiden University, and from PMMH provided by Sorbonne Université. S.N has received funding from European Union’s Horizon 2020 research and innovation programme (grant agreement No. 665385). This work was supported by the Austrian Science Fund (FWF) under projects PAT5044023 and W1250 awarded to C.-P.H.","OA_place":"repository","author":[{"id":"2C0B105C-F248-11E8-B48F-1D18A9856A87","full_name":"Naik, Suyash","first_name":"Suyash","last_name":"Naik","orcid":"0000-0001-8421-5508"}],"citation":{"ista":"Naik S. 2026. Data associated with Keratins coordinate tissue spreading , Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21137\">10.15479/AT-ISTA-21137</a>.","ieee":"S. Naik, “Data associated with Keratins coordinate tissue spreading .” Institute of Science and Technology Austria, 2026.","mla":"Naik, Suyash. <i>Data Associated with Keratins Coordinate Tissue Spreading </i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21137\">10.15479/AT-ISTA-21137</a>.","apa":"Naik, S. (2026). Data associated with Keratins coordinate tissue spreading . Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21137\">https://doi.org/10.15479/AT-ISTA-21137</a>","ama":"Naik S. Data associated with Keratins coordinate tissue spreading . 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21137\">10.15479/AT-ISTA-21137</a>","chicago":"Naik, Suyash. “Data Associated with Keratins Coordinate Tissue Spreading .” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21137\">https://doi.org/10.15479/AT-ISTA-21137</a>.","short":"S. Naik, (2026)."},"title":"Data associated with Keratins coordinate tissue spreading ","oa_version":"Published Version","tmp":{"short":"CC BY-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","image":"/images/cc_by_sa.png"},"type":"research_data","_id":"21137","day":"24","department":[{"_id":"GradSch"},{"_id":"CaHe"},{"_id":"EdHa"}],"has_accepted_license":"1","month":"3","acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"date_updated":"2026-06-10T09:44:10Z"},{"doi":"10.1137/1.9781611978971.148","OA_place":"repository","OA_type":"green","author":[{"id":"b25f2ab2-1fed-11ee-8599-fe02d211784f","last_name":"Arkhipov","first_name":"Pavel","full_name":"Arkhipov, Pavel"},{"id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","full_name":"Kolmogorov, Vladimir","first_name":"Vladimir","last_name":"Kolmogorov"}],"citation":{"ista":"Arkhipov P, Kolmogorov V. 2026. Faster algorithms for packing forests in graphs and related problems. Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 4023–4042.","mla":"Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing Forests in Graphs and Related Problems.” <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Society for Industrial and Applied Mathematics, 2026, pp. 4023–42, doi:<a href=\"https://doi.org/10.1137/1.9781611978971.148\">10.1137/1.9781611978971.148</a>.","ieee":"P. Arkhipov and V. Kolmogorov, “Faster algorithms for packing forests in graphs and related problems,” in <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, Vancouver, Canada, 2026, pp. 4023–4042.","short":"P. Arkhipov, V. Kolmogorov, in:, Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial and Applied Mathematics, 2026, pp. 4023–4042.","apa":"Arkhipov, P., &#38; Kolmogorov, V. (2026). Faster algorithms for packing forests in graphs and related problems. In <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i> (pp. 4023–4042). Vancouver, Canada: Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/1.9781611978971.148\">https://doi.org/10.1137/1.9781611978971.148</a>","ama":"Arkhipov P, Kolmogorov V. Faster algorithms for packing forests in graphs and related problems. In: <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>. Society for Industrial and Applied Mathematics; 2026:4023-4042. doi:<a href=\"https://doi.org/10.1137/1.9781611978971.148\">10.1137/1.9781611978971.148</a>","chicago":"Arkhipov, Pavel, and Vladimir Kolmogorov. “Faster Algorithms for Packing Forests in Graphs and Related Problems.” In <i>Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms</i>, 4023–42. Society for Industrial and Applied Mathematics, 2026. <a href=\"https://doi.org/10.1137/1.9781611978971.148\">https://doi.org/10.1137/1.9781611978971.148</a>."},"title":"Faster algorithms for packing forests in graphs and related problems","oa_version":"Preprint","type":"conference","_id":"21140","publication_status":"published","language":[{"iso":"eng"}],"publication_identifier":{"eisbn":["9781611978971"]},"day":"07","department":[{"_id":"VlKo"}],"conference":{"end_date":"2026-01-14","start_date":"2026-01-11","location":"Vancouver, Canada","name":"SODA: Symposium on Discrete Algorithms"},"month":"01","publication":"Proceedings of the 2026 Annual ACM-SIAM Symposium on Discrete Algorithms","date_updated":"2026-02-16T09:18:33Z","arxiv":1,"publisher":"Society for Industrial and Applied Mathematics","quality_controlled":"1","oa":1,"external_id":{"arxiv":["2409.20314"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2026-01-07T00:00:00Z","article_processing_charge":"No","date_created":"2026-02-05T10:51:34Z","status":"public","page":"4023-4042","corr_author":"1","year":"2026","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2409.20314","open_access":"1"}],"abstract":[{"text":"We consider several problems related to packing forests in graphs. The first one is to find k edge-disjoint forests in a directed graph G of maximal size such that the indegree of each vertex in these forests is at most k. We describe a min-max characterization for this problem and show that it can be solved in almost linear time for fixed k, extending the algorithm of [Gabow, 1995]. Specifically, the complexity is O(kδm log n), where n, m are the number of vertices and edges in G respectively, and δ = max{1, k − kG}, where kG is the edge connectivity of the graph. Using our solution to this problem, we improve complexities for two existing applications:(1) k-forest problem: find k forests in an undirected graph G maximizing the number of edges in their union. We show how to solve this problem in O(k3 min{kn, m} log2 n + k · MAXFLOW(m, m) log n) time, breaking the Ok(n3/2) complexity barrier of previously known approaches.(2) Directed edge-connectivity augmentation problem: find a smallest set of directed edges whose addition to the given directed graph makes it strongly k-connected. We improve the deterministic complexity for this problem from O(kδ(m + δn) log n) [Gabow, STOC 1994] to O(kδm log n). A similar approach with the same complexity also works for the undirected version of the problem.","lang":"eng"}]},{"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"type":"journal_article","oa_version":"Published Version","title":"Bottom-up analysis of rovibrational helical dichroism","volume":136,"citation":{"ista":"Hrast M, Koutentakis G, Maslov M, Lemeshko M. 2026. Bottom-up analysis of rovibrational helical dichroism. Physical Review Letters. 136(5), 053204.","ieee":"M. Hrast, G. Koutentakis, M. Maslov, and M. Lemeshko, “Bottom-up analysis of rovibrational helical dichroism,” <i>Physical Review Letters</i>, vol. 136, no. 5. American Physical Society, 2026.","mla":"Hrast, Mateja, et al. “Bottom-up Analysis of Rovibrational Helical Dichroism.” <i>Physical Review Letters</i>, vol. 136, no. 5, 053204, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/fkf1-1jml\">10.1103/fkf1-1jml</a>.","apa":"Hrast, M., Koutentakis, G., Maslov, M., &#38; Lemeshko, M. (2026). Bottom-up analysis of rovibrational helical dichroism. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/fkf1-1jml\">https://doi.org/10.1103/fkf1-1jml</a>","ama":"Hrast M, Koutentakis G, Maslov M, Lemeshko M. Bottom-up analysis of rovibrational helical dichroism. <i>Physical Review Letters</i>. 2026;136(5). doi:<a href=\"https://doi.org/10.1103/fkf1-1jml\">10.1103/fkf1-1jml</a>","chicago":"Hrast, Mateja, Georgios Koutentakis, Mikhail Maslov, and Mikhail Lemeshko. “Bottom-up Analysis of Rovibrational Helical Dichroism.” <i>Physical Review Letters</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/fkf1-1jml\">https://doi.org/10.1103/fkf1-1jml</a>.","short":"M. Hrast, G. Koutentakis, M. Maslov, M. Lemeshko, Physical Review Letters 136 (2026)."},"OA_type":"hybrid","author":[{"full_name":"Hrast, Mateja","first_name":"Mateja","last_name":"Hrast","id":"48dbb294-2a9c-11ef-905d-f56be71f0e5d"},{"full_name":"Koutentakis, Georgios","first_name":"Georgios","last_name":"Koutentakis","id":"d7b23d3a-9e21-11ec-b482-f76739596b95"},{"full_name":"Maslov, Mikhail","first_name":"Mikhail","last_name":"Maslov","id":"2E65BB0E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4074-2570"},{"last_name":"Lemeshko","full_name":"Lemeshko, Mikhail","first_name":"Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802"}],"OA_place":"publisher","acknowledgement":"This research was funded in whole or in part by the Austrian Science Fund (FWF) [10.55776/F1004].","doi":"10.1103/fkf1-1jml","date_updated":"2026-02-10T11:30:37Z","publication":"Physical Review Letters","article_type":"original","month":"02","article_number":"053204","has_accepted_license":"1","department":[{"_id":"MiLe"}],"day":"05","publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"language":[{"iso":"eng"}],"_id":"21149","publication_status":"published","date_created":"2026-02-06T10:53:17Z","article_processing_charge":"Yes (via OA deal)","file_date_updated":"2026-02-10T11:25:46Z","ddc":["530"],"scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2026-02-05T00:00:00Z","external_id":{"arxiv":["2505.16393"]},"oa":1,"quality_controlled":"1","file":[{"date_updated":"2026-02-10T11:25:46Z","date_created":"2026-02-10T11:25:46Z","file_size":511312,"file_name":"2026_PhysicalReviewLetters_Hrast.pdf","creator":"dernst","success":1,"access_level":"open_access","relation":"main_file","file_id":"21210","content_type":"application/pdf","checksum":"805c929fff9fd4d0e733293eaace67b8"}],"publisher":"American Physical Society","arxiv":1,"abstract":[{"text":"We present a general theoretical framework for helical dichroism (HD), establishing an explicit link between chiral resolution and orbital angular momentum (OAM) exchange in light–matter interaction. Tracing microscopic mechanisms of the OAM transfer, we derive rotational selection rules, which establish that HD emerges only from the spin–orbit coupling of light, even for beams without the far-field OAM. Our findings refine the conditions for observing HD, provide a tool to re-examine the outcome of prior experiments, and guide future designs for chiral sensing with structured light.","lang":"eng"}],"issue":"5","year":"2026","intvolume":"       136","corr_author":"1","PlanS_conform":"1","status":"public","project":[{"name":"Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions","_id":"7c040762-9f16-11ee-852c-dd79eeee4ab3","grant_number":"F100403"}]},{"article_type":"original","month":"01","date_updated":"2026-02-12T14:34:24Z","publication":"Nature Communications","department":[{"_id":"XiFe"}],"day":"27","publication_identifier":{"eissn":["2041-1723"]},"language":[{"iso":"eng"}],"_id":"21158","publication_status":"published","article_number":"999","has_accepted_license":"1","title":"O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering","volume":17,"citation":{"short":"P. Yang, Y. Liu, Q. Dong, Y. Miao, J. Zhang, S. Xu, H. Zhao, Y. Niu, X. Zhang, Y. Xu, Z. Guo, L. Xing, K. Chong, Nature Communications 17 (2026).","ama":"Yang P, Liu Y, Dong Q, et al. O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-025-67734-0\">10.1038/s41467-025-67734-0</a>","chicago":"Yang, Pengfang, Yangyang Liu, Qi Dong, Yuting Miao, Jianlong Zhang, Shujuan Xu, Hong Zhao, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10 Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-025-67734-0\">https://doi.org/10.1038/s41467-025-67734-0</a>.","apa":"Yang, P., Liu, Y., Dong, Q., Miao, Y., Zhang, J., Xu, S., … Chong, K. (2026). O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-67734-0\">https://doi.org/10.1038/s41467-025-67734-0</a>","ieee":"P. Yang <i>et al.</i>, “O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.","mla":"Yang, Pengfang, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10 Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>, vol. 17, 999, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-025-67734-0\">10.1038/s41467-025-67734-0</a>.","ista":"Yang P, Liu Y, Dong Q, Miao Y, Zhang J, Xu S, Zhao H, Niu Y, Zhang X, Xu Y, Guo Z, Xing L, Chong K. 2026. O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. Nature Communications. 17, 999."},"type":"journal_article","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","acknowledgement":"This work was supported by the Basic Science Center Project of National Natural Science Foundation of China (32388201) to K.C and the National Natural Science Foundation of China (31970331) to L.X. We thank Dr. Zhuang Lu, Dr. Bin Han and Ms. Jingquan Li (Plant Science Facility of the Institute of Botany, Chinese Academy of Sciences) for their technical assistance in LC-MS/MS assay, small molecule compound analysis and the subcellular localization assay, respectively. We thank Dr. Wei Luo and Dr. Dongfeng Liu for helpful discussions.","doi":"10.1038/s41467-025-67734-0","OA_type":"gold","author":[{"first_name":"Pengfang","full_name":"Yang, Pengfang","last_name":"Yang"},{"full_name":"Liu, Yangyang","first_name":"Yangyang","last_name":"Liu"},{"last_name":"Dong","full_name":"Dong, Qi","first_name":"Qi"},{"full_name":"Miao, Yuting","first_name":"Yuting","last_name":"Miao"},{"first_name":"Jianlong","full_name":"Zhang, Jianlong","last_name":"Zhang"},{"last_name":"Xu","first_name":"Shujuan","full_name":"Xu, Shujuan","id":"9724dd9d-f591-11ee-bd51-e97ed0652286"},{"last_name":"Zhao","first_name":"Hong","full_name":"Zhao, Hong"},{"full_name":"Niu, Yuda","first_name":"Yuda","last_name":"Niu"},{"full_name":"Zhang, Xueyong","first_name":"Xueyong","last_name":"Zhang"},{"last_name":"Xu","full_name":"Xu, Yunyuan","first_name":"Yunyuan"},{"full_name":"Guo, Zifeng","first_name":"Zifeng","last_name":"Guo"},{"last_name":"Xing","first_name":"Lijing","full_name":"Xing, Lijing"},{"full_name":"Chong, Kang","first_name":"Kang","last_name":"Chong"}],"OA_place":"publisher","year":"2026","abstract":[{"text":"Vernalization-regulated flowering is vital for wheat yield and geographical distribution, and the diversity of flowering time genes is essential for the breeding of climate-resilient varieties. Sugars have long been recognized in regulating flowering; however, the intrinsic connection between carbohydrate metabolism and vernalization response remains largely unexplored. Here, we identify a fructose 1,6-bisphosphate aldolase (FBA) encoding gene, HtL1/FBA10, as a modulator of heading time variation based on a genome-wide association study utilizing wheat core germplasm collections. Evolutionary analysis shows a decrease in the proportion of haplotype-2 of HtL1, which is linked to delayed flowering, in Chinese and American wheat varieties compared to landraces. Vernalization reduces HtL1/FBA10 phosphorylation levels and  increases  its O-GlcNAcylation, which in turn enhances its enzymatic activity and facilitates VERNALIZATION 1 (VRN1) transcription by regulating histone acetylation at the VRN1 locus. Our findings provide mechanistic insights into the interplay between glucose metabolism and the epigenetic regulation of vernalization in winter wheat.","lang":"eng"}],"status":"public","DOAJ_listed":"1","intvolume":"        17","PlanS_conform":"1","pmid":1,"ddc":["580"],"scopus_import":"1","date_published":"2026-01-27T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-02-08T23:02:48Z","file_date_updated":"2026-02-12T14:33:14Z","article_processing_charge":"Yes","external_id":{"pmid":["41455723"]},"oa":1,"quality_controlled":"1","file":[{"checksum":"9ae170ec70ba1ab56b6f1ffe67d1de7f","content_type":"application/pdf","file_id":"21223","access_level":"open_access","relation":"main_file","success":1,"creator":"dernst","file_name":"2026_NatureComm_Yang.pdf","file_size":4685882,"date_updated":"2026-02-12T14:33:14Z","date_created":"2026-02-12T14:33:14Z"}],"publisher":"Springer Nature"},{"publication":"Combinatorica","date_updated":"2026-02-16T09:55:17Z","month":"02","article_type":"original","has_accepted_license":"1","article_number":"5","language":[{"iso":"eng"}],"publication_status":"published","_id":"21159","department":[{"_id":"MaKw"},{"_id":"MoHe"}],"day":"01","publication_identifier":{"eissn":["1439-6912"],"issn":["0209-9683"]},"type":"journal_article","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","volume":46,"citation":{"apa":"Kwan, M. A., Safavi Hemami, R., &#38; Wang, Y. (2026). Counting perfect matchings in Dirac hypergraphs. <i>Combinatorica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00493-025-00194-8\">https://doi.org/10.1007/s00493-025-00194-8</a>","chicago":"Kwan, Matthew Alan, Roodabeh Safavi Hemami, and Yiting Wang. “Counting Perfect Matchings in Dirac Hypergraphs.” <i>Combinatorica</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/s00493-025-00194-8\">https://doi.org/10.1007/s00493-025-00194-8</a>.","ama":"Kwan MA, Safavi Hemami R, Wang Y. Counting perfect matchings in Dirac hypergraphs. <i>Combinatorica</i>. 2026;46. doi:<a href=\"https://doi.org/10.1007/s00493-025-00194-8\">10.1007/s00493-025-00194-8</a>","short":"M.A. Kwan, R. Safavi Hemami, Y. Wang, Combinatorica 46 (2026).","ista":"Kwan MA, Safavi Hemami R, Wang Y. 2026. Counting perfect matchings in Dirac hypergraphs. Combinatorica. 46, 5.","ieee":"M. A. Kwan, R. Safavi Hemami, and Y. Wang, “Counting perfect matchings in Dirac hypergraphs,” <i>Combinatorica</i>, vol. 46. Springer Nature, 2026.","mla":"Kwan, Matthew Alan, et al. “Counting Perfect Matchings in Dirac Hypergraphs.” <i>Combinatorica</i>, vol. 46, 5, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1007/s00493-025-00194-8\">10.1007/s00493-025-00194-8</a>."},"title":"Counting perfect matchings in Dirac hypergraphs","author":[{"first_name":"Matthew Alan","full_name":"Kwan, Matthew Alan","last_name":"Kwan","id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","orcid":"0000-0002-4003-7567"},{"first_name":"Roodabeh","full_name":"Safavi Hemami, Roodabeh","last_name":"Safavi Hemami","id":"72ed2640-8972-11ed-ae7b-f9c81ec75154"},{"orcid":"0000-0002-2856-767X","id":"1917d194-076e-11ed-97cd-837255f88785","last_name":"Wang","first_name":"Yiting","full_name":"Wang, Yiting"}],"OA_type":"hybrid","OA_place":"publisher","doi":"10.1007/s00493-025-00194-8","acknowledgement":"We would like to thank the referees for a number of helpful comments and suggestions, which have substantially improved the paper. Open access funding provided by Institute of Science and Technology (IST Austria).","abstract":[{"text":"One of the foundational theorems of extremal graph theory is Dirac’s theorem, which\r\nsays that if an n-vertex graph G has minimum degree at least n/2, then G has a\r\nHamilton cycle, and therefore a perfect matching (if n is even). Later work by Sárközy,\r\nSelkow and Szemerédi showed that in fact Dirac graphs have many Hamilton cycles\r\nand perfect matchings, culminating in a result of Cuckler and Kahn that gives a precise\r\ndescription of the numbers of Hamilton cycles and perfect matchings in a Dirac graph\r\nG (in terms of an entropy-like parameter of G). In this paper we extend Cuckler\r\nand Kahn’s result to perfect matchings in hypergraphs. For positive integers d < k,\r\nand for n divisible by k, let md (k, n) be the minimum d-degree that ensures the\r\nexistence of a perfect matching in an n-vertex k-uniform hypergraph. In general, it is\r\nan open question to determine (even asymptotically) the values of md (k, n), but we are\r\nnonetheless able to prove an analogue of the Cuckler–Kahn theorem, showing that if\r\nan n-vertex k-uniform hypergraph G has minimum d-degree at least (1+γ )md (k, n)\r\n(for any constantγ > 0), then the number of perfect matchings in G is controlled by\r\nan entropy-like parameter of G. This strengthens cruder estimates arising from work\r\nof Kang–Kelly–Kühn–Osthus–Pfenninger and Pham–Sah–Sawhney–Simkin.","lang":"eng"}],"year":"2026","corr_author":"1","PlanS_conform":"1","intvolume":"        46","status":"public","date_created":"2026-02-08T23:02:49Z","file_date_updated":"2026-02-16T09:52:38Z","article_processing_charge":"Yes (via OA deal)","ddc":["510"],"date_published":"2026-02-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","file":[{"file_name":"2026_Combinatorica_Kwan.pdf","creator":"dernst","file_size":539646,"date_updated":"2026-02-16T09:52:38Z","date_created":"2026-02-16T09:52:38Z","checksum":"47b0031d90b0e6b9a843f422a1486089","file_id":"21228","content_type":"application/pdf","access_level":"open_access","relation":"main_file","success":1}],"arxiv":1,"publisher":"Springer Nature","external_id":{"arxiv":["2408.09589"]},"quality_controlled":"1","oa":1},{"date_created":"2026-02-09T12:04:20Z","article_processing_charge":"Yes","file_date_updated":"2026-02-19T07:39:07Z","ddc":["530"],"user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","date_published":"2026-02-19T00:00:00Z","file":[{"file_size":1347,"date_created":"2026-02-19T07:38:15Z","date_updated":"2026-02-19T07:38:15Z","creator":"kmodic","file_name":"README.txt","access_level":"open_access","relation":"main_file","success":1,"checksum":"53157d908fba663275c2b8dc6ee84fdb","content_type":"text/plain","file_id":"21332"},{"content_type":"application/zip","file_id":"21333","checksum":"b2c8ca5620ee9c181a42082068d3d73c","success":1,"relation":"main_file","access_level":"open_access","creator":"kmodic","file_name":"processed_data_bc_plane_Fig2d.zip","date_created":"2026-02-19T07:39:03Z","date_updated":"2026-02-19T07:39:03Z","file_size":534853},{"file_name":"processed_data_ac_plane_Fig2c.zip","creator":"kmodic","date_created":"2026-02-19T07:39:07Z","date_updated":"2026-02-19T07:39:07Z","file_size":427144,"file_id":"21334","content_type":"application/zip","checksum":"976bf113da4b1133313f0b292e71289f","success":1,"access_level":"open_access","relation":"main_file"}],"publisher":"Institute of Science and Technology Austria","keyword":["transverse magnetic susceptibility","magnetotropic","superconductivity","magnetic fluctuations"],"oa":1,"contributor":[{"orcid":"0000-0002-8806-5719","contributor_type":"project_member","first_name":"Valeska","last_name":"Zambra","id":"467ed36b-dc96-11ea-b7c8-b043a380b282"}],"abstract":[{"text":"UTe2 exhibits the remarkable phenomenon of re-entrant superconductivity, whereby the zero-resistance state reappears above 40 tesla after being suppressed with a field of around 10 tesla. One potential pairing mechanism, invoked in the related re-entrant superconductors UCoGe and URhGe, involves transverse fluctuations of a ferromagnetic order parameter. However, the requisite ferromagnetic order - present in both UCoGe and URhGe - is absent in UTe2, and magnetization measurements show no sign of strong fluctuations. Here, we measure the magnetotropic susceptibility of UTe2 across two field-angle planes. This quantity is sensitive to the magnetic susceptibility in a direction transverse to the applied magnetic field - a quantity that is not accessed in conventional magnetization measurements. We observe a very large decrease in the magnetotropic susceptibility over a broad range of field orientations, indicating a large increase in the transverse magnetic susceptibility. The three superconducting phases of UTe2, including the high-field re-entrant phase, surround this region of enhanced susceptibility in the field-angle phase diagram. The strongest transverse susceptibility is found near the critical end point of the high-field metamagnetic transition, suggesting that quantum critical fluctuations of a field-induced magnetic order parameter may be responsible for the large transverse susceptibility, and may provide a pairing mechanism for field-induced superconductivity in UTe2.","lang":"eng"}],"year":"2026","corr_author":"1","project":[{"_id":"bd968c70-d553-11ed-ba76-cde40b0aba64","name":"Gaining leverage with spin liquids and superconductors","grant_number":"101078696"}],"status":"public","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"type":"research_data","oa_version":"Published Version","citation":{"short":"K.A. Modic, (2026).","apa":"Modic, K. A. (2026). Research data for “Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21174\">https://doi.org/10.15479/AT-ISTA-21174</a>","chicago":"Modic, Kimberly A. “Research Data for ‘Giant Transverse Magnetic Fluctuations at the Edge of Re-Entrant Superconductivity in UTe2.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21174\">https://doi.org/10.15479/AT-ISTA-21174</a>.","ama":"Modic KA. Research data for “Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21174\">10.15479/AT-ISTA-21174</a>","ista":"Modic KA. 2026. Research data for ‘Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21174\">10.15479/AT-ISTA-21174</a>.","ieee":"K. A. Modic, “Research data for ‘Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2.’” Institute of Science and Technology Austria, 2026.","mla":"Modic, Kimberly A. <i>Research Data for “Giant Transverse Magnetic Fluctuations at the Edge of Re-Entrant Superconductivity in UTe2.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21174\">10.15479/AT-ISTA-21174</a>."},"title":"Research data for \"Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2\"","OA_type":"free access","author":[{"orcid":"0000-0001-9760-3147","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425","last_name":"Modic","full_name":"Modic, Kimberly A","first_name":"Kimberly A"}],"OA_place":"repository","doi":"10.15479/AT-ISTA-21174","acknowledgement":"Thanks to Salvatore Bagiante, Evgeniia Volobueva, Lubuna Shafeek, Ali Bangura and Zoltan Kollo.","date_updated":"2026-05-11T06:35:59Z","acknowledged_ssus":[{"_id":"NanoFab"}],"month":"02","has_accepted_license":"1","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"21845"}],"link":[{"url":"https://arxiv.org/pdf/2506.08984","relation":"preprint"}]},"_id":"21174","department":[{"_id":"KiMo"}],"day":"19"},{"doi":"10.64898/2026.01.15.699808","acknowledgement":"We thank Dr. Wenjie Liu for providing critical feedback on the manuscript. We also thank Dr.\r\nPat Pramoonjago at the Biorepository and Tissue Research Facility, and Hope Davis at the\r\nvivarium for their assistance on the project. These Core Facilities are supported by UVA Cancer\r\nCenter grant #P30-CA044579. We are grateful to Dr. Jonathan A. Epstein for providing the\r\nNf1GRD/+ mouse strain (https://pubmed.ncbi.nlm.nih.gov/26460546/). This work was partly\r\nsupported by the National Institute of Neurological Diseases and Stroke R21 NS125479-01A1\r\n(H.Z.), American Cancer Society Institutional Research Grant to the University of Virginia\r\n(Y.J.), the National Natural Science Foundation of China #82072787 (M.Y.), the National\r\nCancer Institute U54 CA238114 (F.W.), U01 CA284193 (K.M.N.), and U54 CA274499 (K.A.J.,\r\nM.F-S.), the National institute of General Medical Sciences R35 GM133404 (M.F-S.), the Dr.\r\nMiriam and Sheldon G. Adelson Medical Research Foundation (H.I.K., S.A.G.), the National\r\nCenter for Advancing Translational Sciences KL2TR001882 (K.S.P.), Tower Cancer Career Development Grant (K.S.P.), McKnight Neurobiology of Brain Disorders Grant (K.S.P.). The\r\ncontent is solely the responsibility of the authors and does not necessarily represent the official\r\nviews of the National Institutes of Health. Illustrations in this manuscript were created with\r\nBioRender (BioRender.com).","oa":1,"OA_type":"green","author":[{"last_name":"Jiang","full_name":"Jiang, Ying","first_name":"Ying"},{"last_name":"Ahn","first_name":"Ryuhjin","full_name":"Ahn, Ryuhjin"},{"last_name":"Huang","first_name":"Arthur","full_name":"Huang, Arthur"},{"last_name":"Gonzalez","first_name":"Phillippe P.","full_name":"Gonzalez, Phillippe P."},{"first_name":"Jungeun","full_name":"Kim, Jungeun","last_name":"Kim"},{"last_name":"Zhang","full_name":"Zhang, Guoxin","first_name":"Guoxin"},{"full_name":"Liu, Zihao","first_name":"Zihao","last_name":"Liu"},{"last_name":"He","first_name":"Zhenqiang","full_name":"He, Zhenqiang"},{"full_name":"Dudley, Lindsey","first_name":"Lindsey","last_name":"Dudley"},{"first_name":"Kunal S.","full_name":"Patel, Kunal S.","last_name":"Patel"},{"last_name":"Dzhivhuho","first_name":"Godfrey A.","full_name":"Dzhivhuho, Godfrey A."},{"last_name":"Crowl","first_name":"Sam","full_name":"Crowl, Sam"},{"full_name":"Przanowski, Piotr","first_name":"Piotr","last_name":"Przanowski"},{"full_name":"Camacho, Luisa Quesada","first_name":"Luisa Quesada","last_name":"Camacho"},{"first_name":"Sijie","full_name":"Hao, Sijie","last_name":"Hao"},{"full_name":"Zeng, Jianhao","first_name":"Jianhao","last_name":"Zeng"},{"full_name":"Hippenmeyer, Simon","first_name":"Simon","last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061"},{"full_name":"Fallahi-Sichani, Mohammad","first_name":"Mohammad","last_name":"Fallahi-Sichani"},{"first_name":"Kevin A.","full_name":"Janes, Kevin A.","last_name":"Janes"},{"first_name":"Kristen M.","full_name":"Naegle, Kristen M.","last_name":"Naegle"},{"full_name":"Hammarskjold, Marie-Louise","first_name":"Marie-Louise","last_name":"Hammarskjold"},{"last_name":"Goldman","first_name":"Steven A.","full_name":"Goldman, Steven A."},{"last_name":"Kornblum","first_name":"Harley I.","full_name":"Kornblum, Harley I."},{"last_name":"Yao","full_name":"Yao, Maojin","first_name":"Maojin"},{"last_name":"White","first_name":"Forest","full_name":"White, Forest"},{"full_name":"Zong, Hui","first_name":"Hui","last_name":"Zong"}],"OA_place":"repository","ddc":["570"],"citation":{"short":"Y. Jiang, R. Ahn, A. Huang, P.P. Gonzalez, J. Kim, G. Zhang, Z. Liu, Z. He, L. Dudley, K.S. Patel, G.A. Dzhivhuho, S. Crowl, P. Przanowski, L.Q. Camacho, S. Hao, J. Zeng, S. Hippenmeyer, M. Fallahi-Sichani, K.A. Janes, K.M. Naegle, M.-L. Hammarskjold, S.A. Goldman, H.I. Kornblum, M. Yao, F. White, H. Zong, BioRxiv (2026).","apa":"Jiang, Y., Ahn, R., Huang, A., Gonzalez, P. P., Kim, J., Zhang, G., … Zong, H. (2026). Critical role of cell competition in gliomagenesis. <i>bioRxiv</i>. <a href=\"https://doi.org/10.64898/2026.01.15.699808\">https://doi.org/10.64898/2026.01.15.699808</a>","chicago":"Jiang, Ying, Ryuhjin Ahn, Arthur Huang, Phillippe P. Gonzalez, Jungeun Kim, Guoxin Zhang, Zihao Liu, et al. “Critical Role of Cell Competition in Gliomagenesis.” <i>BioRxiv</i>, 2026. <a href=\"https://doi.org/10.64898/2026.01.15.699808\">https://doi.org/10.64898/2026.01.15.699808</a>.","ama":"Jiang Y, Ahn R, Huang A, et al. Critical role of cell competition in gliomagenesis. <i>bioRxiv</i>. 2026. doi:<a href=\"https://doi.org/10.64898/2026.01.15.699808\">10.64898/2026.01.15.699808</a>","ista":"Jiang Y, Ahn R, Huang A, Gonzalez PP, Kim J, Zhang G, Liu Z, He Z, Dudley L, Patel KS, Dzhivhuho GA, Crowl S, Przanowski P, Camacho LQ, Hao S, Zeng J, Hippenmeyer S, Fallahi-Sichani M, Janes KA, Naegle KM, Hammarskjold M-L, Goldman SA, Kornblum HI, Yao M, White F, Zong H. 2026. Critical role of cell competition in gliomagenesis. bioRxiv, <a href=\"https://doi.org/10.64898/2026.01.15.699808\">10.64898/2026.01.15.699808</a>.","mla":"Jiang, Ying, et al. “Critical Role of Cell Competition in Gliomagenesis.” <i>BioRxiv</i>, 2026, doi:<a href=\"https://doi.org/10.64898/2026.01.15.699808\">10.64898/2026.01.15.699808</a>.","ieee":"Y. Jiang <i>et al.</i>, “Critical role of cell competition in gliomagenesis,” <i>bioRxiv</i>. 2026."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2026-01-16T00:00:00Z","title":"Critical role of cell competition in gliomagenesis","oa_version":"Preprint","tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"type":"preprint","date_created":"2026-02-10T12:55:55Z","article_processing_charge":"No","language":[{"iso":"eng"}],"publication_status":"published","_id":"21212","department":[{"_id":"SiHi"}],"day":"16","status":"public","has_accepted_license":"1","month":"01","year":"2026","publication":"bioRxiv","main_file_link":[{"url":"https://doi.org/10.64898/2026.01.15.699808","open_access":"1"}],"date_updated":"2026-02-16T10:12:42Z","abstract":[{"text":"Malignant glioma is incurable. Using a mouse genetic mosaic system to generate sporadic Trp53,Nf1-null OPCs, we previously identified oligodendrocyte precursor cell (OPC) as a cell-of-origin of glioma. Here, we report that pre-malignant Trp53,Nf1-null OPCs outcompete wildtype counterparts during their expansion. Blocking competition by mutating/strengthening wildtype OPCs impeded both pre-malignant progression and malignant expansion of glioma.\r\n\r\n“In-tissue” phosphoproteomic profiling revealed an enrichment of phosphopeptides related to RNA splicing and protein translation at the peak of cell competition, suggesting that competitiveness may stem from unique protein species. Among candidates was mTORC1, whose pharmacological inhibition or genetic disruption resulted in a loss of competitiveness in our mouse model. Finally, analysis of patient biopsies and interrogating the role of individual gliomagenic mutations in OPC competition supported its relevance in human gliomas. Together, these findings identified the driving role of competitive interactions among OPCs in gliomagenesis, and suggest unconventional therapeutic strategies to target this process.","lang":"eng"}]},{"month":"01","publication":"Encyclopedia of Astrophysics","date_updated":"2026-02-17T11:05:20Z","language":[{"iso":"eng"}],"publication_status":"published","_id":"21230","department":[{"_id":"LiBu"}],"day":"01","publication_identifier":{"isbn":["9780443214400"]},"citation":{"ista":"Bowman DM, Bugnet LA. 2026.Asteroseismology. In: Encyclopedia of Astrophysics. vol. 2, 133–153.","ieee":"D. M. Bowman and L. A. Bugnet, “Asteroseismology,” in <i>Encyclopedia of Astrophysics</i>, vol. 2, I. Mandel, Ed. Elsevier, 2026, pp. 133–153.","mla":"Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” <i>Encyclopedia of Astrophysics</i>, edited by Ilya Mandel, vol. 2, Elsevier, 2026, pp. 133–53, doi:<a href=\"https://doi.org/10.1016/b978-0-443-21439-4.00036-5\">10.1016/b978-0-443-21439-4.00036-5</a>.","apa":"Bowman, D. M., &#38; Bugnet, L. A. (2026). Asteroseismology. In I. Mandel (Ed.), <i>Encyclopedia of Astrophysics</i> (Vol. 2, pp. 133–153). Elsevier. <a href=\"https://doi.org/10.1016/b978-0-443-21439-4.00036-5\">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>","chicago":"Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” In <i>Encyclopedia of Astrophysics</i>, edited by Ilya Mandel, 2:133–53. Elsevier, 2026. <a href=\"https://doi.org/10.1016/b978-0-443-21439-4.00036-5\">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>.","ama":"Bowman DM, Bugnet LA. Asteroseismology. In: Mandel I, ed. <i>Encyclopedia of Astrophysics</i>. Vol 2. Elsevier; 2026:133-153. doi:<a href=\"https://doi.org/10.1016/b978-0-443-21439-4.00036-5\">10.1016/b978-0-443-21439-4.00036-5</a>","short":"D.M. Bowman, L.A. Bugnet, in:, I. Mandel (Ed.), Encyclopedia of Astrophysics, Elsevier, 2026, pp. 133–153."},"volume":2,"title":"Asteroseismology","oa_version":"Preprint","type":"book_chapter","editor":[{"last_name":"Mandel","full_name":"Mandel, Ilya","first_name":"Ilya"}],"doi":"10.1016/b978-0-443-21439-4.00036-5","author":[{"first_name":"Dominic M.","full_name":"Bowman, Dominic M.","last_name":"Bowman"},{"id":"d9edb345-f866-11ec-9b37-d119b5234501","last_name":"Bugnet","first_name":"Lisa Annabelle","full_name":"Bugnet, Lisa Annabelle","orcid":"0000-0003-0142-4000"}],"OA_type":"green","OA_place":"repository","year":"2026","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2410.01715"}],"abstract":[{"lang":"eng","text":"Asteroseismology is the study of the interior physics and structure of stars using their pulsations. It is applicable to stars across the Hertzsprung–Russell (HR) diagram and a powerful technique not only to measure masses, radii, and ages but also directly constrain interior rotation, chemical mixing, and magnetism. This is because a star's self-excited pulsation modes are sensitive to its structure. Asteroseismology generally requires long-duration and high-precision time-series data. The method of forward asteroseismic modeling, which is the statistical comparison of observed pulsation mode frequencies to theoretically predicted pulsation frequencies calculated from a grid of models, provides precise constraints for calibrating various transport phenomena. In this introduction to asteroseismology, we provide an overview of its principles, and the typical data sets and methodologies used to constrain stellar interiors. Finally, we present key highlights of asteroseismic results from across the HR diagram, and conclude with ongoing challenges and future prospects for this ever-expanding field within stellar astrophysics."}],"status":"public","page":"133-153","intvolume":"         2","date_published":"2026-01-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","date_created":"2026-02-16T10:43:01Z","article_processing_charge":"No","publisher":"Elsevier","arxiv":1,"external_id":{"arxiv":["2410.01715"]},"quality_controlled":"1","oa":1},{"publisher":"Springer Nature","file":[{"checksum":"99b2e6bbaaedf45f22e07751948669f5","content_type":"application/pdf","file_id":"21346","relation":"main_file","access_level":"open_access","success":1,"file_name":"2026_npjSysBioApp_Arruda.pdf","creator":"dernst","file_size":10217687,"date_updated":"2026-02-23T10:09:03Z","date_created":"2026-02-23T10:09:03Z"}],"quality_controlled":"1","oa":1,"external_id":{"pmid":["41611727"]},"file_date_updated":"2026-02-23T10:09:03Z","article_processing_charge":"Yes (via OA deal)","date_created":"2026-02-16T10:44:31Z","date_published":"2026-02-05T00:00:00Z","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["570"],"pmid":1,"PlanS_conform":"1","intvolume":"        12","DOAJ_listed":"1","status":"public","abstract":[{"lang":"eng","text":"To assess cell migration in complex spatial environments, microfabricated chips, such as mazes and pillar forests, are routinely used to impose spatial and mechanical constraints, and cell trajectories are followed within these structures by advanced imaging techniques. In systems mechanobiology, computational models serve as essential tools to uncover how physical geometry influences intracellular dynamics; however, decoding such complex behaviors requires advanced inference techniques. Here, we integrated experimental observations of dendritic cell migration in a geometrically constrained microenvironment into a Cellular Potts model. We demonstrated that these spatial constraints modulate the motility dynamics, including speed and directional changes. We show that classical summary statistics, such as mean squared displacement and turning angle distributions, can resolve key mechanistic features but fail to extract richer spatiotemporal patterns, limiting accurate parameter inference. To solve this, we applied neural posterior estimation with in-the-loop learning of summary features. This learned summary representation of the data enables robust and flexible parameter inference, providing a data-driven framework for model calibration and advancing quantitative analysis of cell migration in structured microenvironments."}],"year":"2026","OA_place":"publisher","author":[{"last_name":"Arruda","first_name":"Jonas","full_name":"Arruda, Jonas"},{"first_name":"Emad","full_name":"Alamoudi, Emad","last_name":"Alamoudi"},{"last_name":"Mueller","first_name":"Robert","full_name":"Mueller, Robert"},{"full_name":"Vaisband, Marc","first_name":"Marc","last_name":"Vaisband"},{"first_name":"Ronja","full_name":"Molkenbur, Ronja","last_name":"Molkenbur"},{"orcid":"0000-0001-5145-4609","id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack","first_name":"Jack","last_name":"Merrin"},{"full_name":"Kiermaier, Eva","first_name":"Eva","last_name":"Kiermaier"},{"last_name":"Hasenauer","full_name":"Hasenauer, Jan","first_name":"Jan"}],"OA_type":"gold","doi":"10.1038/s41540-026-00648-9","acknowledgement":"This work was supported by the German Federal Ministry of Education and Research (BMBF) (EMUNE/031L0293C), the European Union via the ERC grant INTEGRATE, grant agreement number 101126146, and under Germany’s Excellence Strategy by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (EXC 2047—390685813, EXC 2151—390873048, FOR5775 — 533863915, and 524747443), the University of Bonn via the Schlegel Professorship of J.H., and the returning experts fellowship of the Ministry of Innovation, Science, and Research of North-Rhine-Westphalia (AZ: 421-8.03.03.02-137069). J.M. is a member of the Nanofabrication Facility and is supported by the Institute of Science and Technology Austria. E.K. acknowledges the TRA Life and Health (University of Bonn) as part of the Excellence Strategy of the federal and state governments. The authors thank Laeschkir Würthner for his insightful comments on the implementation of the authors’ model. The views and opinions expressed are those of the authors only and do not necessarily reflect those of the funding agencies. Parts of Fig. 1 were created using BioRender. Open Access funding enabled and organized by Projekt DEAL.","type":"journal_article","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","citation":{"short":"J. Arruda, E. Alamoudi, R. Mueller, M. Vaisband, R. Molkenbur, J. Merrin, E. Kiermaier, J. Hasenauer, Npj Systems Biology and Applications 12 (2026).","chicago":"Arruda, Jonas, Emad Alamoudi, Robert Mueller, Marc Vaisband, Ronja Molkenbur, Jack Merrin, Eva Kiermaier, and Jan Hasenauer. “Simulation-Based Inference of Cell Migration Dynamics in Complex Spatial Environments.” <i>Npj Systems Biology and Applications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41540-026-00648-9\">https://doi.org/10.1038/s41540-026-00648-9</a>.","ama":"Arruda J, Alamoudi E, Mueller R, et al. Simulation-based inference of cell migration dynamics in complex spatial environments. <i>npj Systems Biology and Applications</i>. 2026;12. doi:<a href=\"https://doi.org/10.1038/s41540-026-00648-9\">10.1038/s41540-026-00648-9</a>","apa":"Arruda, J., Alamoudi, E., Mueller, R., Vaisband, M., Molkenbur, R., Merrin, J., … Hasenauer, J. (2026). Simulation-based inference of cell migration dynamics in complex spatial environments. <i>Npj Systems Biology and Applications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41540-026-00648-9\">https://doi.org/10.1038/s41540-026-00648-9</a>","mla":"Arruda, Jonas, et al. “Simulation-Based Inference of Cell Migration Dynamics in Complex Spatial Environments.” <i>Npj Systems Biology and Applications</i>, vol. 12, 20, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41540-026-00648-9\">10.1038/s41540-026-00648-9</a>.","ieee":"J. Arruda <i>et al.</i>, “Simulation-based inference of cell migration dynamics in complex spatial environments,” <i>npj Systems Biology and Applications</i>, vol. 12. Springer Nature, 2026.","ista":"Arruda J, Alamoudi E, Mueller R, Vaisband M, Molkenbur R, Merrin J, Kiermaier E, Hasenauer J. 2026. Simulation-based inference of cell migration dynamics in complex spatial environments. npj Systems Biology and Applications. 12, 20."},"volume":12,"title":"Simulation-based inference of cell migration dynamics in complex spatial environments","has_accepted_license":"1","article_number":"20","publication_status":"published","_id":"21231","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["2056-7189"]},"department":[{"_id":"NanoFab"}],"day":"05","publication":"npj Systems Biology and Applications","date_updated":"2026-02-23T10:10:10Z","month":"02","article_type":"original"},{"year":"2026","abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title>\r\n                  <jats:p>In this paper, we consider a simple class of stratified spaces – 2-complexes. We present an algorithm that learns the abstract structure of an embedded 2-complex from a point cloud sampled from it. We use tools and inspiration from computational geometry, algebraic topology, and topological data analysis and prove the correctness of the identified abstract structure under assumptions on the embedding.</jats:p>"}],"status":"public","intvolume":"         5","corr_author":"1","PlanS_conform":"1","ddc":["510"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","date_published":"2026-02-08T00:00:00Z","date_created":"2026-02-16T10:44:44Z","file_date_updated":"2026-02-23T10:18:52Z","article_processing_charge":"Yes (via OA deal)","external_id":{"arxiv":["2305.02724"]},"oa":1,"quality_controlled":"1","file":[{"success":1,"access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"21347","checksum":"6cae2efb47b025af22a8539c606a4e09","date_updated":"2026-02-23T10:18:52Z","date_created":"2026-02-23T10:18:52Z","file_size":15051582,"file_name":"2026_LaMatematica_Bleile.pdf","creator":"dernst"}],"publisher":"Springer Nature","arxiv":1,"article_type":"original","month":"02","date_updated":"2026-06-11T11:51:14Z","publication":"La Matematica","department":[{"_id":"HeEd"}],"day":"08","publication_identifier":{"issn":["2730-9657"]},"language":[{"iso":"eng"}],"_id":"21232","publication_status":"published","article_number":"17","has_accepted_license":"1","title":"Towards stratified space learning: 2-complexes","citation":{"mla":"Bokor Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.” <i>La Matematica</i>, vol. 5, 17, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1007/s44007-025-00183-9\">10.1007/s44007-025-00183-9</a>.","ieee":"Y. Bokor Bleile, “Towards stratified space learning: 2-complexes,” <i>La Matematica</i>, vol. 5. Springer Nature, 2026.","ista":"Bokor Bleile Y. 2026. Towards stratified space learning: 2-complexes. La Matematica. 5, 17.","chicago":"Bokor Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.” <i>La Matematica</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/s44007-025-00183-9\">https://doi.org/10.1007/s44007-025-00183-9</a>.","ama":"Bokor Bleile Y. Towards stratified space learning: 2-complexes. <i>La Matematica</i>. 2026;5. doi:<a href=\"https://doi.org/10.1007/s44007-025-00183-9\">10.1007/s44007-025-00183-9</a>","apa":"Bokor Bleile, Y. (2026). Towards stratified space learning: 2-complexes. <i>La Matematica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s44007-025-00183-9\">https://doi.org/10.1007/s44007-025-00183-9</a>","short":"Y. Bokor Bleile, La Matematica 5 (2026)."},"volume":5,"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"type":"journal_article","oa_version":"Published Version","acknowledgement":"The author would like to thank Kate Turner, Chris Williams, Jonathan Spreer, Stephan Tillmann, Vanessa Robins, Vigleik Angeltveit, Martin Helmer, and James Morgan for very helpful discussions; and thanks Sara Kališnik Hintz and Paul Bendich for comments on an earlier version. Additonally, the author would like to thank both reviewers for their very insightful and helpful comments, without which the paper would be infinitely less coherent than it currently is. Open access funding provided by Institute of Science and Technology (IST Austria). The work in this paper was supported by an Australian Federal Government Grant, 2019-2022, Stratified Space Learning.","doi":"10.1007/s44007-025-00183-9","author":[{"orcid":"0000-0002-4861-9174","id":"920a7385-7995-11ef-9bfd-8c434cd8f3c2","last_name":"Bleile","first_name":"Yossi","full_name":"Bleile, Yossi"}],"OA_type":"hybrid","OA_place":"publisher"},{"date_published":"2026-02-18T00:00:00Z","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"ddc":["570"],"article_processing_charge":"No","file_date_updated":"2026-02-23T10:32:12Z","date_created":"2026-02-16T10:45:10Z","publisher":"Elsevier","file":[{"checksum":"920e8edfd3b8b42f5bb6f86d4c66c54d","file_id":"21349","content_type":"application/pdf","access_level":"open_access","relation":"main_file","success":1,"creator":"dernst","file_name":"2026_CellSystems_GomezPascual.pdf","file_size":10606778,"date_created":"2026-02-23T10:32:12Z","date_updated":"2026-02-23T10:32:12Z"}],"oa":1,"quality_controlled":"1","external_id":{"pmid":["41633365"]},"year":"2026","abstract":[{"lang":"eng","text":"In aged humans and mice, hypobranched glycogen aggregates, known as polyglucosan bodies (PGBs), accumulate in hippocampal astrocytes. While PGBs are linked to cognitive decline in neurological diseases, they remain largely unstudied in the context of typical aging. We show that PGBs arise in autophagy-dysregulated astrocytes in the aged hippocampus, with substantial variation among 32 inbred BXD mouse strains. Genetic mapping through quantitative trait locus analysis identified a major locus (Pgb1) that modulates hippocampal PGB burden. Extensive transcriptomic and proteomic datasets were produced for the aged hippocampus of the BXD family to investigate the mechanism by which the Pgb1 locus modulates PGB burden. We identified that Pgb1 contains allelic Smarcal1 and Usp37 variants and influences PGB burden through trans-regulation of mRNA and protein expression levels, including abundance of glycogen-mobilizing factor PYGB. Furthermore, comprehensive phenome-wide association scans, transcriptomic analyses, and direct behavioral testing demonstrated that cognition remains intact despite age-related PGB burden. A record of this paper’s transparent peer review process is included in the supplemental information."}],"issue":"2","status":"public","PlanS_conform":"1","intvolume":"        17","citation":{"apa":"Gómez-Pascual, A., Glikman, D. M., Ng, H. X., Tomkins, J. E., Lu, L., Xu, Y., … de Bakker, D. E. M. (2026). The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cels.2025.101488\">https://doi.org/10.1016/j.cels.2025.101488</a>","chicago":"Gómez-Pascual, Alicia, Dow M Glikman, Hui Xin Ng, James E. Tomkins, Lu Lu, Ying Xu, David G. Ashbrook, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.cels.2025.101488\">https://doi.org/10.1016/j.cels.2025.101488</a>.","ama":"Gómez-Pascual A, Glikman DM, Ng HX, et al. The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>. 2026;17(2). doi:<a href=\"https://doi.org/10.1016/j.cels.2025.101488\">10.1016/j.cels.2025.101488</a>","short":"A. Gómez-Pascual, D.M. Glikman, H.X. Ng, J.E. Tomkins, L. Lu, Y. Xu, D.G. Ashbrook, C. Kaczorowski, G. Kempermann, J. Killmar, K. Mozhui, O. Ohlenschläger, R. Aebersold, D.K. Ingram, E.G. Williams, M. Jucker, R.W. Overall, R.W. Williams, D.E.M. de Bakker, Cell Systems 17 (2026).","ista":"Gómez-Pascual A, Glikman DM, Ng HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski C, Kempermann G, Killmar J, Mozhui K, Ohlenschläger O, Aebersold R, Ingram DK, Williams EG, Jucker M, Overall RW, Williams RW, de Bakker DEM. 2026. The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. Cell Systems. 17(2), 101488.","mla":"Gómez-Pascual, Alicia, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>, vol. 17, no. 2, 101488, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.cels.2025.101488\">10.1016/j.cels.2025.101488</a>.","ieee":"A. Gómez-Pascual <i>et al.</i>, “The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus,” <i>Cell Systems</i>, vol. 17, no. 2. Elsevier, 2026."},"volume":17,"title":"The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus","oa_version":"Published Version","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"type":"journal_article","doi":"10.1016/j.cels.2025.101488","acknowledgement":"We would like to thank the Summer School Systems Genetics of Neural Ageing for bringing us together and spurring our international collaboration. We would also like to acknowledge the funding for the Summer School 2022 from the e:Med Systems Medicine Program of the BMBF (Bundesministerium für Bildung und Forschung; German Ministry of Education and Research) to R.W.O. In addition, we would like to thank the FLI imaging core facility for their assistance. A.G.-P. is supported by Fundación Séneca, Región de Murcia, Spain (21259/FPI/19). D.E.M.d.B. is financed by a Rubicon scholarship (452021116) from the Dutch Research Council (NWO). This work was also supported by NIH NIA R01AG070913-01 (R.W.W.), R01AG075813-01 (D.G.A.), and R01AG075818 (C.K.). We acknowledge the help of Larry Mobraaten (Jackson Laboratory, Bar Harbor, MN) with the BXD strains and U. Obermüller for the help with the histology. For the purpose of open access, the authors have applied a CC BY public copyright license to all author-accepted manuscripts arising from this submission.","OA_place":"publisher","OA_type":"hybrid","author":[{"last_name":"Gómez-Pascual","first_name":"Alicia","full_name":"Gómez-Pascual, Alicia"},{"id":"ab8acda1-91c1-11f0-aad8-f75d3d6424d8","last_name":"Glikman","full_name":"Glikman, Dow M","first_name":"Dow M"},{"last_name":"Ng","full_name":"Ng, Hui Xin","first_name":"Hui Xin"},{"first_name":"James E.","full_name":"Tomkins, James E.","last_name":"Tomkins"},{"last_name":"Lu","full_name":"Lu, Lu","first_name":"Lu"},{"last_name":"Xu","first_name":"Ying","full_name":"Xu, Ying"},{"first_name":"David G.","full_name":"Ashbrook, David G.","last_name":"Ashbrook"},{"full_name":"Kaczorowski, Catherine","first_name":"Catherine","last_name":"Kaczorowski"},{"last_name":"Kempermann","first_name":"Gerd","full_name":"Kempermann, Gerd"},{"last_name":"Killmar","full_name":"Killmar, John","first_name":"John"},{"last_name":"Mozhui","full_name":"Mozhui, Khyobeni","first_name":"Khyobeni"},{"full_name":"Ohlenschläger, Oliver","first_name":"Oliver","last_name":"Ohlenschläger"},{"last_name":"Aebersold","first_name":"Rudolf","full_name":"Aebersold, Rudolf"},{"first_name":"Donald K.","full_name":"Ingram, Donald K.","last_name":"Ingram"},{"last_name":"Williams","first_name":"Evan G.","full_name":"Williams, Evan G."},{"full_name":"Jucker, Mathias","first_name":"Mathias","last_name":"Jucker"},{"full_name":"Overall, Rupert W.","first_name":"Rupert W.","last_name":"Overall"},{"last_name":"Williams","full_name":"Williams, Robert W.","first_name":"Robert W."},{"first_name":"Dennis E.M.","full_name":"de Bakker, Dennis E.M.","last_name":"de Bakker"}],"month":"02","article_type":"original","publication":"Cell Systems","date_updated":"2026-02-23T10:35:01Z","_id":"21234","publication_status":"published","language":[{"iso":"eng"}],"publication_identifier":{"issn":["2405-4712"]},"day":"18","department":[{"_id":"GradSch"}],"has_accepted_license":"1","article_number":"101488"},{"type":"journal_article","oa_version":"Preprint","citation":{"short":"A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, L. Bocquet, Physical Review Fluids 11 (2026).","chicago":"Dombret, Albert, Adrien Sutter, Baptiste Coquinot, Nikita Kavokine, Benoit Coasne, and Lydéric Bocquet. “Hydrodynamic Permeability of Fluctuating Porous Membranes.” <i>Physical Review Fluids</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/m8h6-1wfk\">https://doi.org/10.1103/m8h6-1wfk</a>.","ama":"Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. Hydrodynamic permeability of fluctuating porous membranes. <i>Physical Review Fluids</i>. 2026;11(1). doi:<a href=\"https://doi.org/10.1103/m8h6-1wfk\">10.1103/m8h6-1wfk</a>","apa":"Dombret, A., Sutter, A., Coquinot, B., Kavokine, N., Coasne, B., &#38; Bocquet, L. (2026). Hydrodynamic permeability of fluctuating porous membranes. <i>Physical Review Fluids</i>. American Physical Society. <a href=\"https://doi.org/10.1103/m8h6-1wfk\">https://doi.org/10.1103/m8h6-1wfk</a>","mla":"Dombret, Albert, et al. “Hydrodynamic Permeability of Fluctuating Porous Membranes.” <i>Physical Review Fluids</i>, vol. 11, no. 1, 014201, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/m8h6-1wfk\">10.1103/m8h6-1wfk</a>.","ieee":"A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, and L. Bocquet, “Hydrodynamic permeability of fluctuating porous membranes,” <i>Physical Review Fluids</i>, vol. 11, no. 1. American Physical Society, 2026.","ista":"Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. 2026. Hydrodynamic permeability of fluctuating porous membranes. Physical Review Fluids. 11(1), 014201."},"volume":11,"title":"Hydrodynamic permeability of fluctuating porous membranes","OA_place":"repository","author":[{"full_name":"Dombret, Albert","first_name":"Albert","last_name":"Dombret"},{"full_name":"Sutter, Adrien","first_name":"Adrien","last_name":"Sutter"},{"orcid":"0000-0001-5524-596X","last_name":"Coquinot","first_name":"Baptiste","full_name":"Coquinot, Baptiste","id":"f8417bd4-f599-11ee-a482-b927e3ed1e8e"},{"last_name":"Kavokine","first_name":"Nikita","full_name":"Kavokine, Nikita"},{"last_name":"Coasne","full_name":"Coasne, Benoit","first_name":"Benoit"},{"first_name":"Lydéric","full_name":"Bocquet, Lydéric","last_name":"Bocquet"}],"OA_type":"green","doi":"10.1103/m8h6-1wfk","acknowledgement":"The authors acknowledge support from ERC project n-AQUA, Grant Agreement No. 101071937.\r\nB.C. and A.S. acknowledge support from the CFM Foundation. B.C. acknowledges support from\r\nthe NOMIS Foundation.","publication":"Physical Review Fluids","date_updated":"2026-02-23T12:01:57Z","month":"01","article_type":"original","article_number":"014201","_id":"21273","publication_status":"published","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["2469-990X"]},"department":[{"_id":"MiLe"}],"day":"21","article_processing_charge":"No","date_created":"2026-02-17T08:10:09Z","date_published":"2026-01-21T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","arxiv":1,"publisher":"American Physical Society","oa":1,"quality_controlled":"1","external_id":{"arxiv":["2512.11368"]},"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2512.11368","open_access":"1"}],"issue":"1","abstract":[{"text":"In this paper we examine how porosity fluctuations affect the hydrodynamic permeability of a porous matrix or membrane. We introduce a fluctuating Darcy model, which couples the Navier-Stokes equation to the space- and time-dependent porosity fluctuations via a Darcy friction term. Using a perturbative approach, a Dyson equation for hydrodynamic fluctuations is derived and solved to express the permeability in terms of the matrix fluctuation spectrum. Surprisingly, the model reveals strong modifications of the fluid permeability in fluctuating matrices compared to static ones. Applications to various matrix excitation models, the breathing matrix, phonons, and active forcing, highlight the significant influence of matrix fluctuations on fluid transport, offering insights for optimizing membrane design for separation applications.","lang":"eng"}],"year":"2026","corr_author":"1","intvolume":"        11","status":"public"},{"DOAJ_listed":"1","status":"public","corr_author":"1","PlanS_conform":"1","intvolume":"       706","year":"2026","abstract":[{"text":"Many white dwarfs are observed in compact double white dwarf binaries, and through the emission of gravitational waves, a large fraction are destined to merge. The merger remnants that do not explode in a Type Ia supernova are expected to initially be rapidly rotating and highly magnetized. In this work, we present our discovery of the variable white dwarf ZTF J200832.79+444939.67, hereafter ZTF J2008+4449, as a likely merger remnant showing signs of circumstellar material without a stellar or substellar companion. The nature of ZTF J2008+4449 as a merger remnant is supported by its physical properties: it is hot (35 500 ± 300 K) and massive (1.12 ± 0.03 M\r\n                    <jats:sub>⊙</jats:sub>\r\n                    ), rapidly rotating with a period of ≈6.6 minutes, and likely possesses exceptionally strong magnetic fields (∼400−600 MG) at its surface. Remarkably, we detect a significant period derivative of (1.80 ± 0.09)×10\r\n                    <jats:sup>−12</jats:sup>\r\n                    s/s, indicating that the white dwarf is spinning down, and a soft X-ray emission that is inconsistent with photospheric emission. As the presence of a mass-transferring stellar or brown dwarf companion is excluded by infrared photometry, the detected spin-down and X-ray emission could be tell-tale signs of a magnetically driven wind or of interaction with circumstellar material, possibly originating from the fallback of gravitationally bound merger ejecta or from the tidal disruption of a planetary object. We also detect Balmer emission, which requires the presence of ionized hydrogen in the vicinity of the white dwarf, showing Doppler shifts as high as ≈2000 km s\r\n                    <jats:sup>−1</jats:sup>\r\n                    . The unusual variability of the Balmer emission on the spin period of the white dwarf is consistent with the trapping of a half ring of ionized gas in the magnetosphere of the white dwarf.\r\n                  </jats:p>","lang":"eng"}],"file":[{"creator":"dernst","file_name":"2026_AstronomyAstrophysics_Cristea.pdf","file_size":5352853,"date_created":"2026-02-23T12:04:37Z","date_updated":"2026-02-23T12:04:37Z","checksum":"229b688e6e78cab5bb8e2bac366d1575","content_type":"application/pdf","file_id":"21350","relation":"main_file","access_level":"open_access","success":1}],"publisher":"EDP Sciences","quality_controlled":"1","oa":1,"ddc":["520"],"date_published":"2026-02-10T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_created":"2026-02-17T08:12:05Z","article_processing_charge":"Yes","file_date_updated":"2026-02-23T12:04:37Z","language":[{"iso":"eng"}],"publication_status":"published","_id":"21274","department":[{"_id":"IlCa"},{"_id":"GradSch"}],"day":"10","publication_identifier":{"issn":["0004-6361"],"eissn":["1432-0746"]},"has_accepted_license":"1","related_material":{"link":[{"url":"https://ista.ac.at/en/news/twos-company-new-class-of-star-remnants/","description":"News on ISTA website","relation":"press_release"}]},"article_number":"A188","month":"02","article_type":"original","publication":"Astronomy & Astrophysics","date_updated":"2026-04-28T12:01:21Z","doi":"10.1051/0004-6361/202556432","acknowledgement":"We thank Lynne Hillenbrand and Soumyadeep Bhattacharjee for helpful discussions, and Kishalay De for his help with the WIRC\r\nreduction pipeline. IC was supported by NASA through grants from the Space\r\nTelescope Science Institute, under NASA contracts NASA.22K1813, NAS5-\r\n26555 and NAS5-03127. TC was supported by NASA through the NASA Hubble\r\nFellowship grant HST-HF2-51527.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research\r\nin Astronomy, Inc., for NASA, under contract NAS5-26555. This project has\r\nreceived funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 101020057). This work was based on observations obtained with the\r\nSamuel Oschin Telescope 48-inch and the 60-inch Telescope at the Palomar\r\nObservatory as part of the Zwicky Transient Facility project. ZTF is supported\r\nby the National Science Foundation under Grants No. AST-1440341, AST2034437, and currently Award #2407588. ZTF receives additional funding from\r\nthe ZTF partnership. Current members include Caltech, USA; Caltech/IPAC,\r\nUSA; University of Maryland, USA; University of California, Berkeley, USA;\r\nUniversity of Wisconsin at Milwaukee, USA; Cornell University, USA; Drexel\r\nUniversity, USA; University of North Carolina at Chapel Hill, USA; Institute\r\nof Science and Technology, Austria; National Central University, Taiwan, and\r\nOKC, University of Stockholm, Sweden. Operations are conducted by Caltech’s\r\nOptical Observatory (COO), Caltech/IPAC, and the University of Washington at\r\nSeattle, USA. This work has made use of data from the European Space Agency\r\n(ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by\r\nthe Gaia Data Processing and Analysis Consortium (DPAC, https://www.\r\ncosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. The Pan-STARRS1 Surveys (PS1)\r\nand the PS1 public science archive have been made possible through contributions by the Institute for Astronomy, the University of Hawaii, the PanSTARRS Project Office, the Max-Planck Society and its participating institutes, the Max Planck Institute for Astronomy, Heidelberg and the Max Planck\r\nInstitute for Extraterrestrial Physics, Garching, The Johns Hopkins University,\r\nDurham University, the University of Edinburgh, the Queen’s University Belfast,\r\nthe Harvard-Smithsonian Center for Astrophysics, the Las Cumbres Observatory Global Telescope Network Incorporated, the National Central University of Taiwan, the Space Telescope Science Institute, the National Aeronautics and Space Administration under Grant No. NNX08AR22G issued through\r\nthe Planetary Science Division of the NASA Science Mission Directorate, the\r\nNational Science Foundation Grant No. AST–1238877, the University of Maryland, Eotvos Lorand University (ELTE), the Los Alamos National Laboratory,\r\nand the Gordon and Betty Moore Foundation. This work made use of Astropy\r\n(http://www.astropy.org): a community-developed core Python package\r\nand an ecosystem of tools and resources for astronomy (Astropy Collaboration\r\n2013, 2018, 2022).","author":[{"id":"4d500bea-31f8-11ee-a48d-d4904fb363c7","full_name":"Cristea, Andrei-Alexandru","first_name":"Andrei-Alexandru","last_name":"Cristea"},{"orcid":"0000-0002-4770-5388","last_name":"Caiazzo","first_name":"Ilaria","full_name":"Caiazzo, Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d"},{"last_name":"Cunningham","full_name":"Cunningham, Tim","first_name":"Tim"},{"last_name":"Raymond","full_name":"Raymond, John C.","first_name":"John C."},{"full_name":"Vennes, Stephane","first_name":"Stephane","last_name":"Vennes"},{"first_name":"Adela","full_name":"Kawka, Adela","last_name":"Kawka"},{"id":"502cfd30-32c1-11ee-a9a4-d8dad5c6739e","last_name":"Desai","first_name":"Aayush A","full_name":"Desai, Aayush A"},{"full_name":"Miller, David R.","first_name":"David R.","last_name":"Miller"},{"full_name":"Hermes, J. J.","first_name":"J. J.","last_name":"Hermes"},{"full_name":"Fuller, Jim","first_name":"Jim","last_name":"Fuller"},{"full_name":"Heyl, Jeremy","first_name":"Jeremy","last_name":"Heyl"},{"full_name":"van Roestel, Jan","first_name":"Jan","last_name":"van Roestel"},{"first_name":"Kevin B.","full_name":"Burdge, Kevin B.","last_name":"Burdge"},{"last_name":"Rodriguez","full_name":"Rodriguez, Antonio C.","first_name":"Antonio C."},{"full_name":"Pelisoli, Ingrid","first_name":"Ingrid","last_name":"Pelisoli"},{"last_name":"Gänsicke","first_name":"Boris T.","full_name":"Gänsicke, Boris T."},{"first_name":"Paula","full_name":"Szkody, Paula","last_name":"Szkody"},{"last_name":"Kenyon","full_name":"Kenyon, Scott J.","first_name":"Scott J."},{"last_name":"Vanderbosch","full_name":"Vanderbosch, Zach","first_name":"Zach"},{"last_name":"Drake","first_name":"Andrew","full_name":"Drake, Andrew"},{"first_name":"Lilia","full_name":"Ferrario, Lilia","last_name":"Ferrario"},{"first_name":"Dayal","full_name":"Wickramasinghe, Dayal","last_name":"Wickramasinghe"},{"last_name":"Karambelkar","first_name":"Viraj R.","full_name":"Karambelkar, Viraj R."},{"full_name":"Justham, Stephen","first_name":"Stephen","last_name":"Justham"},{"full_name":"Pakmor, Ruediger","first_name":"Ruediger","last_name":"Pakmor"},{"full_name":"El-Badry, Kareem","first_name":"Kareem","last_name":"El-Badry"},{"first_name":"Thomas","full_name":"Prince, Thomas","last_name":"Prince"},{"first_name":"S. R.","full_name":"Kulkarni, S. R.","last_name":"Kulkarni"},{"full_name":"Graham, Matthew J.","first_name":"Matthew J.","last_name":"Graham"},{"full_name":"Masci, Frank J.","first_name":"Frank J.","last_name":"Masci"},{"last_name":"Groom","first_name":"Steven L.","full_name":"Groom, Steven L."},{"last_name":"Purdum","full_name":"Purdum, Josiah","first_name":"Josiah"},{"last_name":"Dekany","full_name":"Dekany, Richard","first_name":"Richard"},{"full_name":"Bellm, Eric C.","first_name":"Eric C.","last_name":"Bellm"}],"OA_type":"gold","OA_place":"publisher","volume":706,"citation":{"apa":"Cristea, A.-A., Caiazzo, I., Cunningham, T., Raymond, J. C., Vennes, S., Kawka, A., … Bellm, E. C. (2026). A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/202556432\">https://doi.org/10.1051/0004-6361/202556432</a>","chicago":"Cristea, Andrei-Alexandru, Ilaria Caiazzo, Tim Cunningham, John C. Raymond, Stephane Vennes, Adela Kawka, Aayush A Desai, et al. “A Half Ring of Ionized Circumstellar Material Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2026. <a href=\"https://doi.org/10.1051/0004-6361/202556432\">https://doi.org/10.1051/0004-6361/202556432</a>.","ama":"Cristea A-A, Caiazzo I, Cunningham T, et al. A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant. <i>Astronomy &#38; Astrophysics</i>. 2026;706. doi:<a href=\"https://doi.org/10.1051/0004-6361/202556432\">10.1051/0004-6361/202556432</a>","short":"A.-A. Cristea, I. Caiazzo, T. Cunningham, J.C. Raymond, S. Vennes, A. Kawka, A.A. Desai, D.R. Miller, J.J. Hermes, J. Fuller, J. Heyl, J. van Roestel, K.B. Burdge, A.C. Rodriguez, I. Pelisoli, B.T. Gänsicke, P. Szkody, S.J. Kenyon, Z. Vanderbosch, A. Drake, L. Ferrario, D. Wickramasinghe, V.R. Karambelkar, S. Justham, R. Pakmor, K. El-Badry, T. Prince, S.R. Kulkarni, M.J. Graham, F.J. Masci, S.L. Groom, J. Purdum, R. Dekany, E.C. Bellm, Astronomy &#38; Astrophysics 706 (2026).","ista":"Cristea A-A, Caiazzo I, Cunningham T, Raymond JC, Vennes S, Kawka A, Desai AA, Miller DR, Hermes JJ, Fuller J, Heyl J, van Roestel J, Burdge KB, Rodriguez AC, Pelisoli I, Gänsicke BT, Szkody P, Kenyon SJ, Vanderbosch Z, Drake A, Ferrario L, Wickramasinghe D, Karambelkar VR, Justham S, Pakmor R, El-Badry K, Prince T, Kulkarni SR, Graham MJ, Masci FJ, Groom SL, Purdum J, Dekany R, Bellm EC. 2026. A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant. Astronomy &#38; Astrophysics. 706, A188.","ieee":"A.-A. Cristea <i>et al.</i>, “A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant,” <i>Astronomy &#38; Astrophysics</i>, vol. 706. EDP Sciences, 2026.","mla":"Cristea, Andrei-Alexandru, et al. “A Half Ring of Ionized Circumstellar Material Trapped in the Magnetosphere of a White Dwarf Merger Remnant.” <i>Astronomy &#38; Astrophysics</i>, vol. 706, A188, EDP Sciences, 2026, doi:<a href=\"https://doi.org/10.1051/0004-6361/202556432\">10.1051/0004-6361/202556432</a>."},"title":"A half ring of ionized circumstellar material trapped in the magnetosphere of a white dwarf merger remnant","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","type":"journal_article"},{"language":[{"iso":"eng"}],"_id":"21275","publication_status":"published","day":"09","department":[{"_id":"EdHa"}],"publication_identifier":{"eissn":["2835-8279"]},"has_accepted_license":"1","article_number":"013018","month":"02","article_type":"original","publication":"PRX Life","date_updated":"2026-02-24T06:54:32Z","doi":"10.1103/89bj-79g5","acknowledgement":"This project has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No. 950349 and the Marie Skłodowska-Curie Grant Agreement No. 101034413. The computations in this paper were run in part on the the FASRC Cannon cluster supported by the FAS Division of Science Research Computing Group at Harvard University and the cluster of the Max Planck Institute for the Physics of Complex Systems.","author":[{"last_name":"Olmeda","first_name":"Fabrizio","full_name":"Olmeda, Fabrizio","id":"69dbf5fb-8a76-11ed-866b-fb486d8b5689"},{"last_name":"Gupta","first_name":"Misha","full_name":"Gupta, Misha"},{"last_name":"Bektas","first_name":"Onurcan","full_name":"Bektas, Onurcan"},{"last_name":"Rulands","first_name":"Steffen","full_name":"Rulands, Steffen"}],"OA_type":"gold","OA_place":"publisher","volume":4,"citation":{"ieee":"F. Olmeda, M. Gupta, O. Bektas, and S. Rulands, “Spatiotemporal patterns of active epigenetic turnover,” <i>PRX Life</i>, vol. 4. American Physical Society, 2026.","mla":"Olmeda, Fabrizio, et al. “Spatiotemporal Patterns of Active Epigenetic Turnover.” <i>PRX Life</i>, vol. 4, 013018, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/89bj-79g5\">10.1103/89bj-79g5</a>.","ista":"Olmeda F, Gupta M, Bektas O, Rulands S. 2026. Spatiotemporal patterns of active epigenetic turnover. PRX Life. 4, 013018.","ama":"Olmeda F, Gupta M, Bektas O, Rulands S. Spatiotemporal patterns of active epigenetic turnover. <i>PRX Life</i>. 2026;4. doi:<a href=\"https://doi.org/10.1103/89bj-79g5\">10.1103/89bj-79g5</a>","chicago":"Olmeda, Fabrizio, Misha Gupta, Onurcan Bektas, and Steffen Rulands. “Spatiotemporal Patterns of Active Epigenetic Turnover.” <i>PRX Life</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/89bj-79g5\">https://doi.org/10.1103/89bj-79g5</a>.","apa":"Olmeda, F., Gupta, M., Bektas, O., &#38; Rulands, S. (2026). Spatiotemporal patterns of active epigenetic turnover. <i>PRX Life</i>. American Physical Society. <a href=\"https://doi.org/10.1103/89bj-79g5\">https://doi.org/10.1103/89bj-79g5</a>","short":"F. Olmeda, M. Gupta, O. Bektas, S. Rulands, PRX Life 4 (2026)."},"title":"Spatiotemporal patterns of active epigenetic turnover","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","type":"journal_article","project":[{"name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","grant_number":"101034413"}],"DOAJ_listed":"1","status":"public","corr_author":"1","PlanS_conform":"1","intvolume":"         4","year":"2026","abstract":[{"lang":"eng","text":"DNA methylation is a primary layer of epigenetic modification that plays a pivotal role in the regulation of development, aging, and cancer. The concurrent activity of opposing enzymes that mediate DNA methylation and demethylation gives rise to a biochemical cycle and active turnover of DNA methylation. While the ensuing biochemical oscillations have been implicated in the regulation of cell differentiation, their functional role and spatiotemporal dynamics are unknown. In this work, we demonstrate that chromatin-mediated coupling between these local biochemical cycles can lead to the emergence of phase-locked domains, regions of locally synchronized turnover activity, whose coarsening is arrested by genomic heterogeneity. We introduce a minimal model based on stochastic oscillators with constrained long-range and nonreciprocal interactions, shaped by the local chromatin organization. Through a combination of analytical theory and stochastic simulations, we predict both the degree of synchronization and the typical size of emergent phase-locked domains. We qualitatively test these predictions using single-cell sequencing data. Our results show that DNA methylation turnover exhibits surprisingly rich spatiotemporal patterns that may be used by cells to control cell differentiation."}],"file":[{"date_updated":"2026-02-24T06:53:05Z","date_created":"2026-02-24T06:53:05Z","file_size":5857833,"file_name":"2026_PRXLife_Olmeda.pdf","creator":"dernst","success":1,"access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"21351","checksum":"df9776422862d1d02c66d98e2d620849"}],"publisher":"American Physical Society","quality_controlled":"1","oa":1,"ddc":["570"],"date_published":"2026-02-09T00:00:00Z","ec_funded":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-02-17T08:17:53Z","article_processing_charge":"Yes","file_date_updated":"2026-02-24T06:53:05Z"},{"doi":"10.1103/fdcf-dkws","acknowledgement":"We thank Edouard Hannezo, Anna Kicheva, Fridtjof Brauns, and all members of the Brückner and Tkačik groups for feedback and inspiring discussions. This work was supported in part by European Research Council ERC-2023-SyG “Dynatrans” Grant No. 101118866 (G.T.). This work was conducted while visiting the Okinawa Institute of Science and Technology (OIST) through the Theoretical Sciences Visiting Program (TSVP); at the Kavli Institute for Theoretical Physics (KITP) Santa Barbara, supported by NSF Grant No. PHY-1748958 and the Gordon and Betty Moore Foundation Grant No. 2919.02; and at Lucullus, Vienna.","OA_place":"publisher","author":[{"orcid":"0000-0001-7205-2975","last_name":"Brückner","first_name":"David","full_name":"Brückner, David","id":"e1e86031-6537-11eb-953a-f7ab92be508d"},{"first_name":"Gašper","full_name":"Tkačik, Gašper","last_name":"Tkačik","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6699-1455"}],"OA_type":"gold","citation":{"ista":"Brückner D, Tkačik G. 2026. Marr’s three levels for embryonic development: Information, dynamical systems, gene networks. PRX Life. 4, 017001.","mla":"Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic Development: Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>, vol. 4, 017001, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/fdcf-dkws\">10.1103/fdcf-dkws</a>.","ieee":"D. Brückner and G. Tkačik, “Marr’s three levels for embryonic development: Information, dynamical systems, gene networks,” <i>PRX Life</i>, vol. 4. American Physical Society, 2026.","short":"D. Brückner, G. Tkačik, PRX Life 4 (2026).","apa":"Brückner, D., &#38; Tkačik, G. (2026). Marr’s three levels for embryonic development: Information, dynamical systems, gene networks. <i>PRX Life</i>. American Physical Society. <a href=\"https://doi.org/10.1103/fdcf-dkws\">https://doi.org/10.1103/fdcf-dkws</a>","chicago":"Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic Development: Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/fdcf-dkws\">https://doi.org/10.1103/fdcf-dkws</a>.","ama":"Brückner D, Tkačik G. Marr’s three levels for embryonic development: Information, dynamical systems, gene networks. <i>PRX Life</i>. 2026;4. doi:<a href=\"https://doi.org/10.1103/fdcf-dkws\">10.1103/fdcf-dkws</a>"},"volume":4,"title":"Marr's three levels for embryonic development: Information, dynamical systems, gene networks","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","type":"journal_article","_id":"21282","publication_status":"published","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["2835-8279"]},"department":[{"_id":"GaTk"}],"day":"23","has_accepted_license":"1","article_number":"017001","month":"01","article_type":"original","publication":"PRX Life","date_updated":"2026-02-24T07:00:16Z","arxiv":1,"publisher":"American Physical Society","file":[{"date_updated":"2026-02-24T06:57:44Z","date_created":"2026-02-24T06:57:44Z","file_size":1147994,"file_name":"2026_PRXLife_Brueckner.pdf","creator":"dernst","success":1,"relation":"main_file","access_level":"open_access","file_id":"21352","content_type":"application/pdf","checksum":"99ef02dd741c4536eeefd12d409d5269"}],"quality_controlled":"1","oa":1,"external_id":{"arxiv":["2510.24536"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2026-01-23T00:00:00Z","ddc":["570"],"file_date_updated":"2026-02-24T06:57:44Z","article_processing_charge":"Yes","date_created":"2026-02-17T08:29:10Z","project":[{"_id":"7bfe6a29-9f16-11ee-852c-c0da5e2045d9","name":"Transcription in 4D: the dynamic interplay between chromatin architecture and gene expression in developing pseudo-embryos","grant_number":"101118866"}],"DOAJ_listed":"1","status":"public","PlanS_conform":"1","corr_author":"1","intvolume":"         4","year":"2026","abstract":[{"text":"Developmental patterning comprises processes that range from purely instructed, where external signals specify cell fates, to fully self-organized, where spatial patterns emerge autonomously through cellular interactions. We propose that both extremes—as well as the continuum of intermediate cases—can be conceptualized as information-processing systems, whose operation can be described using “Marr's three levels of analysis”: the computational problem being solved, the algorithms employed, and their molecular implementation. At the first level, we argue that normative theories, such as information-theoretic optimization principles, provide a formalization of the computational problem. At the second level, we show how simplified information-processing architectures provide a framework for developmental algorithms, which are formalized mathematically using dynamical systems theory. At the third level, the implementation of developmental algorithms is described by mechanistic biophysical and gene regulatory network models.","lang":"eng"}]},{"status":"public","corr_author":"1","year":"2026","abstract":[{"text":"The advantageous characteristics attributed to the 19F nucleus have made it a popular target for NMR once again in recent years. Aside from solution NMR, an increasing number of studies have been conducted applying solid-state magic-angle-spinning NMR to fluorine-labeled samples. Here, the high chemical shift anisotropy and strong dipolar couplings can be utilized to get structural insights into proteins and measure long distances. Despite increasing popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labeled biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F and 13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labeled protein via 19F-detected MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially reduces measurement times of 19F MAS NMR experiments without compromising resolution. Additionally, we report the chemical-shift assignments of all four fluorotryptophan signals in the 12 × 39 kDa large protein using a mutagenesis approach.","lang":"eng"}],"contributor":[{"id":"334a5e40-8747-11f0-b671-ba1f5154b4b4","first_name":"Giorgia","contributor_type":"researcher","last_name":"Toscano"},{"last_name":"Kapitonova","contributor_type":"researcher","first_name":"Anna","id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471"},{"id":"a3089acd-6806-11ee-bacc-f0c7d500ad20","first_name":"Rajkumar","contributor_type":"researcher","last_name":"Singh"},{"last_name":"Guillerm","contributor_type":"researcher","first_name":"Undina","id":"bb74f472-ae54-11eb-9835-bc9c22fb1183"},{"contributor_type":"researcher","first_name":"Roman","last_name":"Lichtenecker"}],"oa":1,"publisher":"Institute of Science and Technology Austria","file":[{"file_name":"Research_data.zip","creator":"lbecker","file_size":36996027,"date_created":"2026-02-17T10:11:14Z","date_updated":"2026-02-17T10:11:14Z","checksum":"2d3105f26be578073b88ee1f2ea0bdb1","file_id":"21285","content_type":"application/zip","access_level":"open_access","relation":"main_file","success":1},{"creator":"lbecker","file_name":"README.txt","date_created":"2026-02-17T10:11:14Z","date_updated":"2026-02-17T10:11:14Z","file_size":1993,"file_id":"21286","content_type":"text/plain","checksum":"e24aebcdb8856cb181cbaa02de020ddb","relation":"table_of_contents","access_level":"open_access"}],"date_published":"2026-02-18T00:00:00Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","ddc":["541"],"article_processing_charge":"No","file_date_updated":"2026-02-17T10:11:14Z","date_created":"2026-02-17T10:17:14Z","department":[{"_id":"GradSch"},{"_id":"PaSc"}],"day":"18","_id":"21284","has_accepted_license":"1","month":"2","acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"date_updated":"2026-06-10T09:28:41Z","acknowledgement":"We thank Ben P. Tatman for insightful discussions. This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance Facility and the Lab Support Facility.","doi":"10.15479/AT-ISTA-21284","OA_place":"repository","author":[{"orcid":"0000-0002-6401-5151","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","first_name":"Lea Marie","full_name":"Becker, Lea Marie","last_name":"Becker"},{"last_name":"Schanda","full_name":"Schanda, Paul","first_name":"Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","orcid":"0000-0002-9350-7606"}],"OA_type":"free access","title":"Research data for \"Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants\"","citation":{"ista":"Becker LM, Schanda P. 2026. Research data for ‘Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21284\">10.15479/AT-ISTA-21284</a>.","ieee":"L. M. Becker and P. Schanda, “Research data for ‘Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.’” Institute of Science and Technology Austria, 2026.","mla":"Becker, Lea Marie, and Paul Schanda. <i>Research Data for “Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21284\">10.15479/AT-ISTA-21284</a>.","apa":"Becker, L. M., &#38; Schanda, P. (2026). Research data for “Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21284\">https://doi.org/10.15479/AT-ISTA-21284</a>","chicago":"Becker, Lea Marie, and Paul Schanda. “Research Data for ‘Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21284\">https://doi.org/10.15479/AT-ISTA-21284</a>.","ama":"Becker LM, Schanda P. Research data for “Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21284\">10.15479/AT-ISTA-21284</a>","short":"L.M. Becker, P. Schanda, (2026)."},"tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png"},"oa_version":"Published Version","type":"research_data"},{"oa_version":"Preprint","type":"preprint","date_created":"2026-02-17T11:35:59Z","article_processing_charge":"No","citation":{"ista":"Polat Haas F, Villalba Requena A, Rusina P, Gopalan A, Fritz H, Akhmetkaliyev A, Ruehle F, Einsiedel A, Szczepinska A, Kielisch F, Chen J-X, Nguyen S, Schmidlin T, Hippenmeyer S, Bailicata MF, Keller Valsecchi CI. The splicing paralogues SNRPB and SNRPN control differential metabolic states. bioRxiv, <a href=\"https://doi.org/10.64898/2026.02.11.705284\">10.64898/2026.02.11.705284</a>.","ieee":"F. Polat Haas <i>et al.</i>, “The splicing paralogues SNRPB and SNRPN control differential metabolic states.,” <i>bioRxiv</i>. .","mla":"Polat Haas, Feyza, et al. “The Splicing Paralogues SNRPB and SNRPN Control Differential Metabolic States.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.64898/2026.02.11.705284\">10.64898/2026.02.11.705284</a>.","short":"F. Polat Haas, A. Villalba Requena, P. Rusina, A. Gopalan, H. Fritz, A. Akhmetkaliyev, F. Ruehle, A. Einsiedel, A. Szczepinska, F. Kielisch, J.-X. Chen, S. Nguyen, T. Schmidlin, S. Hippenmeyer, M.F. Bailicata, C.I. Keller Valsecchi, BioRxiv (n.d.).","apa":"Polat Haas, F., Villalba Requena, A., Rusina, P., Gopalan, A., Fritz, H., Akhmetkaliyev, A., … Keller Valsecchi, C. I. (n.d.). The splicing paralogues SNRPB and SNRPN control differential metabolic states. <i>bioRxiv</i>. <a href=\"https://doi.org/10.64898/2026.02.11.705284\">https://doi.org/10.64898/2026.02.11.705284</a>","ama":"Polat Haas F, Villalba Requena A, Rusina P, et al. The splicing paralogues SNRPB and SNRPN control differential metabolic states. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.64898/2026.02.11.705284\">10.64898/2026.02.11.705284</a>","chicago":"Polat Haas, Feyza, Ana Villalba Requena, Polina Rusina, Anusha Gopalan, Hector Fritz, Azamat Akhmetkaliyev, Frank Ruehle, et al. “The Splicing Paralogues SNRPB and SNRPN Control Differential Metabolic States.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.64898/2026.02.11.705284\">https://doi.org/10.64898/2026.02.11.705284</a>."},"date_published":"2026-02-11T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"The splicing paralogues SNRPB and SNRPN control differential metabolic states.","author":[{"last_name":"Polat Haas","first_name":"Feyza","full_name":"Polat Haas, Feyza"},{"orcid":"0000-0002-5615-5277","last_name":"Villalba Requena","full_name":"Villalba Requena, Ana","first_name":"Ana","id":"68cb85a0-39f7-11eb-9559-9aaab4f6a247"},{"full_name":"Rusina, Polina","first_name":"Polina","last_name":"Rusina"},{"last_name":"Gopalan","first_name":"Anusha","full_name":"Gopalan, Anusha"},{"first_name":"Hector","full_name":"Fritz, Hector","last_name":"Fritz"},{"full_name":"Akhmetkaliyev, Azamat","first_name":"Azamat","last_name":"Akhmetkaliyev"},{"full_name":"Ruehle, Frank","first_name":"Frank","last_name":"Ruehle"},{"last_name":"Einsiedel","first_name":"Anna","full_name":"Einsiedel, Anna"},{"first_name":"Anna","full_name":"Szczepinska, Anna","last_name":"Szczepinska"},{"full_name":"Kielisch, Fridolin","first_name":"Fridolin","last_name":"Kielisch"},{"full_name":"Chen, Jia-Xuan","first_name":"Jia-Xuan","last_name":"Chen"},{"last_name":"Nguyen","full_name":"Nguyen, Susanne","first_name":"Susanne"},{"last_name":"Schmidlin","first_name":"Thierry","full_name":"Schmidlin, Thierry"},{"orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","first_name":"Simon","full_name":"Hippenmeyer, Simon"},{"last_name":"Bailicata","first_name":"M. Felicia","full_name":"Bailicata, M. Felicia"},{"last_name":"Keller Valsecchi","full_name":"Keller Valsecchi, Claudia Isabelle","first_name":"Claudia Isabelle"}],"OA_type":"green","OA_place":"repository","doi":"10.64898/2026.02.11.705284","acknowledgement":"We thank Oliver Mühlemann and Alex Hofer (University of Bern) for sharing SMG inhibitors\r\nand for their expertise in nonsense-mediated mRNA decay and Maria Hondele for critical\r\nreading of the manuscript draft. We also thank the IMB Genomics Core Facility for assistance\r\nwith library preparation and sequencing, Martin Möckel and the IMB Protein Production Core\r\nFacility for providing enzymes used in this work, Marton Gelleri together with the IMB\r\nMicroscopy Core Facility for support with microscopy and FRAP experiments, Jasmin Cartano\r\nfor proteomics sample processing and the IMB Flow Cytometry Core Facility for support. In\r\naddition, we thank the Imaging Core Facility (IMCF) and the FACS Core Facility at the\r\nBiozentrum, University of Basel, for technical assistance. CIKV acknowledges funding by the\r\nDeutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Individual Grant\r\nProject no. 513744403, Scientific Network Grant Project no. 531902894, GRK2526 “Genevo”\r\n- Project no. 407023052”, GRK2859 (“4R”) - Project no. 491145305, Forschungsinitiative\r\nRheinland-Pfalz (ReALity), the EMBO Young Investigator Program (5795), institutional\r\nfunding from the Institute of Molecular Biology and funds from the Kanton Basel-Stadt and\r\nBasel-Land provided to the Biozentrum of the University Basel. J.H.G.F.G. was part of the\r\n‘Science of Healthy Ageing Research Programme’ (SHARP) initiative funded by RhinelandPalatinate’s Ministry of Science, Education and Culture. PR is funded by the Biozentrum PhD\r\nFellowships Program. MFB received financial support from the intramural High Potentials\r\nGrant program of the University Medical Center Mainz, Forschungsinitiative Rheinland-Pfalz\r\n(ReALity) and Stiftungen zugunsten der Medizinischen Fakultät der LMU Klinikum (26069).\r\nInstruments in the IMB core facilities were supported by funds from the DFG: Laser Scanning\r\nConfocal (Leica Stellaris 8 Falcon, funded by the DFG - Project #497669232), Orbitrap Astral system (funded by the DFG - Project #524805621) and BD LSRFortessa SOPR is funded by\r\nthe DFG - Project #210253511.\r\n","oa":1,"main_file_link":[{"url":"https://doi.org/10.64898/2026.02.11.705284","open_access":"1"}],"publication":"bioRxiv","date_updated":"2026-02-23T11:03:33Z","abstract":[{"lang":"eng","text":"Gene duplication underlies evolutionary innovation, yet many paralogues remain highly similar, raising questions about their functional divergence and physiological relevance. The spliceosomal Sm core protein SNRPB and its mammalian-specific paralogue SNRPN share over 90% sequence identity, but their distinct expression patterns - SNRPB being ubiquitous and SNRPN confined to the brain - suggest specialized functions. Why mammals have two different spliceosomes has remained obscure. Here, we generated isogenic human cell lines expressing ectopically either SNRPB or SNRPN exclusively and found that SNRPN stabilizes transcripts involved in energy metabolism and mitochondrial function, leading to increased mitochondrial abundance and oxygen consumption. Despite similar spliceosomal interactomes, SNRPN more strongly associates with the PRMT5 methylosome complex and exhibits dynamic arginine methylation in its C-terminal region that is sensitive to translation inhibition and amino acid availability. The SNRPN-dependent transcriptome responds to translation inhibition by stabilizing long, intron-rich genes involved in amino acid and energy metabolism. Our findings reveal a nutrient-sensitive, methylation-dependent mechanism that differentiates the two paralogues. This suggests that SNRPN functions as a metabolic-specialized spliceosomal subunit thereby providing tissue-specific adaptation of RNA processing in mammals."}],"month":"02","year":"2026","language":[{"iso":"eng"}],"publication_status":"submitted","_id":"21290","day":"11","status":"public","department":[{"_id":"SiHi"}]},{"author":[{"last_name":"Gobeil","first_name":"Sophie A","full_name":"Gobeil, Sophie A","id":"2f3e9efb-eb24-11ec-86b2-88efb11d59fa"},{"id":"8cfb7412-10a7-11f1-add1-82b44e6418f2","first_name":"Francisco","full_name":"Da Silveira Neto, Francisco","last_name":"Da Silveira Neto"},{"id":"12632ae8-799e-11ef-94a2-e5a3b5ef49e9","last_name":"Silvestrelli","first_name":"Giulia","full_name":"Silvestrelli, Giulia"},{"full_name":"Smits, Matthijs Geert","first_name":"Matthijs Geert","last_name":"Smits","id":"7a231d52-e216-11ee-a0bb-8acd55f8f1f0"},{"id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","last_name":"Streicher","first_name":"Carmen","full_name":"Streicher, Carmen"},{"orcid":"0000-0001-8457-2572","id":"471195F6-F248-11E8-B48F-1D18A9856A87","first_name":"Giselle T","full_name":"Cheung, Giselle T","last_name":"Cheung"},{"orcid":"0000-0003-2279-1061","first_name":"Simon","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Lora Beatrice Jaeger","full_name":"Sweeney, Lora Beatrice Jaeger","last_name":"Sweeney","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","orcid":"0000-0001-9242-5601"}],"OA_type":"green","OA_place":"repository","doi":"10.64898/2026.02.12.705305","acknowledgement":"We would like to thank Elizabeth Marin, Anna Kicheva, Igor Adameyko, and James Briscoe as\r\nwell as members of the Sweeney and Hippemeyer labs and SFB consortium for comments on\r\nthe manuscript. We are also grateful for the technical support of the Preclinical and Imaging and\r\nOptics Facilities support teams (ISTA). In addition, we thank our funding sources for providing\r\nthe resources to do these experiments: Horizon Europe ERC Starting Grant Number 101041551\r\n(M.S.; L.B.S.); Special Research Program (SFB) of the Austrian Science Fund (FWF)\r\nNeuroStem Modulation Project numbers F7814-B (S.A.G.; M.S.; G.S.; and L.B.S.) and F7805\r\n(G.C. and S.H.). S.A.G is supported by a Boehringer Ingelheim Fonds PhD Fellowship, F.D.S.N.\r\nby an Institute of Science and Technology Austria (ISTA) GROW fellowship, and G.C. by an\r\nISTA Plus postdoctoral fellowship from the European Commission. S.H./L.B.S. and G.C. were\r\nadditionally supported by institutional funds from the ISTA and the University of Exeter,\r\nrespectively. ","type":"preprint","tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"oa_version":"Preprint","citation":{"short":"S.A. Gobeil, F. Da Silveira Neto, G. Silvestrelli, M.G. Smits, C. Streicher, G.T. Cheung, S. Hippenmeyer, L.B. Sweeney, BioRxiv (n.d.).","chicago":"Gobeil, Sophie A, Francisco Da Silveira Neto, Giulia Silvestrelli, Matthijs Geert Smits, Carmen Streicher, Giselle T Cheung, Simon Hippenmeyer, and Lora B. Sweeney. “Lineage Origin of Spinal Cord Cell Type Diversity.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.64898/2026.02.12.705305\">https://doi.org/10.64898/2026.02.12.705305</a>.","ama":"Gobeil SA, Da Silveira Neto F, Silvestrelli G, et al. Lineage origin of spinal cord cell type diversity. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.64898/2026.02.12.705305\">10.64898/2026.02.12.705305</a>","apa":"Gobeil, S. A., Da Silveira Neto, F., Silvestrelli, G., Smits, M. G., Streicher, C., Cheung, G. T., … Sweeney, L. B. (n.d.). Lineage origin of spinal cord cell type diversity. <i>bioRxiv</i>. <a href=\"https://doi.org/10.64898/2026.02.12.705305\">https://doi.org/10.64898/2026.02.12.705305</a>","mla":"Gobeil, Sophie A., et al. “Lineage Origin of Spinal Cord Cell Type Diversity.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.64898/2026.02.12.705305\">10.64898/2026.02.12.705305</a>.","ieee":"S. A. Gobeil <i>et al.</i>, “Lineage origin of spinal cord cell type diversity,” <i>bioRxiv</i>. .","ista":"Gobeil SA, Da Silveira Neto F, Silvestrelli G, Smits MG, Streicher C, Cheung GT, Hippenmeyer S, Sweeney LB. Lineage origin of spinal cord cell type diversity. bioRxiv, <a href=\"https://doi.org/10.64898/2026.02.12.705305\">10.64898/2026.02.12.705305</a>."},"title":"Lineage origin of spinal cord cell type diversity","has_accepted_license":"1","language":[{"iso":"eng"}],"_id":"21291","publication_status":"submitted","department":[{"_id":"SiHi"},{"_id":"LoSw"}],"day":"16","publication":"bioRxiv","date_updated":"2026-04-14T08:16:55Z","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"}],"month":"02","oa":1,"date_created":"2026-02-17T11:36:20Z","article_processing_charge":"No","ddc":["570"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2026-02-16T00:00:00Z","corr_author":"1","project":[{"grant_number":"101041551","_id":"ebb66355-77a9-11ec-83b8-b8ac210a4dae","name":"Development and Evolution of Tetrapod Motor Circuits"},{"_id":"8da85f50-16d5-11f0-9cad-eab8b0ff6c9e","name":"Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb transition: cell type to connection diversity","grant_number":"F7814"},{"grant_number":"F7805","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression","_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E"}],"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.64898/2026.02.12.705305"}],"abstract":[{"lang":"eng","text":"The complexity and specificity of movement in vertebrates is driven by a rich diversity of spinal motor and interneuron cell types. During development, eleven spinal cord progenitor domains generate an equivalent number of cardinal neuron types. How progenitor domains, individual progenitors, and post-mitotic diversity relate is still unknown. We performed high-resolution, single-progenitor cell lineage tracing in the embryonic mouse spinal cord using mosaic analysis with double markers (MADM). Our quantitative study of lineage progression revealed that spinal cord progenitors undergo highly variable numbers of proliferative, neurogenic, and gliogenic cell divisions. The nascent clonally-related neurons migrate radially over large distances, span the dorsoventral axis, and even cross the midline, demonstrating striking bilaterality. Molecular and morphometric analysis indicate high levels of progenitor multipotency, with an individual progenitor capable of producing several molecularly and morphologically distinct neuron types, as well as astrocytes. These findings redefine spinal cord development as a process in which lineage variability — rather than rigid progenitor identity — drives the generation of cellular diversity."}],"year":"2026"},{"PlanS_conform":"1","corr_author":"1","status":"public","abstract":[{"text":"Air pollution is a critical public health issue worldwide, South America faces unique challenges due to rapid urban growth, industrial expansion, and recurrent biomass burning. Existing studies have largely focused on regional or national scales, overlooking detailed spatio-temporal dynamics in cities. This study provides a comprehensive assessment of air pollution spatio-temporal trends from 2013 to 2023 in six major South American cities: Bogotá, Buenos Aires, Montevideo, Quito, Santiago de Chile, and São Paulo. We evaluated four key pollutants, NO2, O3, PM10, and PM2.5, using in situ monitoring networks complemented with reanalysis (boundary layer and pollution dynamics), and fire detections datasets (biomass burning). A key innovation is the use of a Lagrangian Tracker, which identifies persistent hotspots and transport pathways of pollutants, offering new insights into transboundary pollution. Results show that nearly all cities experienced reductions in particulate matter concentrations, while three of the six cities exhibited rising O3 levels, reflecting complex interactions between emissions, meteorology, and atmospheric chemistry. Santiago de Chile recorded the highest levels of NO2 and PM, strongly influenced by topography and biomass burning in JJA. Bogotá and Quito were notably impacted by regional fire emissions, whereas coastal cities such as Buenos Aires and Montevideo benefited from greater pollutant dispersion but still exceeded the World Health Organization guidelines. By integrating ground-based, satellite, and reanalysis data with advanced trajectory modeling, this research provides detailed spatio-temporal evaluations of air pollution in South America and highlights the urgent need for coordinated regional strategies to reduce health and economic burdens.","lang":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1007/s41748-026-01068-9","open_access":"1"}],"year":"2026","oa":1,"quality_controlled":"1","publisher":"Springer Nature","article_processing_charge":"Yes (via OA deal)","date_created":"2026-02-18T07:11:14Z","date_published":"2026-02-17T00:00:00Z","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["550"],"has_accepted_license":"1","publication_identifier":{"issn":["2509-9426"],"eissn":["2509-9434"]},"department":[{"_id":"CaMu"}],"day":"17","_id":"21311","publication_status":"epub_ahead","language":[{"iso":"eng"}],"date_updated":"2026-02-23T11:57:21Z","publication":"Earth Systems and Environment","article_type":"original","month":"02","OA_place":"publisher","author":[{"last_name":"González","first_name":"Yuri","full_name":"González, Yuri"},{"last_name":"Malagón","first_name":"Nicolás","full_name":"Malagón, Nicolás"},{"last_name":"Benavides","full_name":"Benavides, Kevin","first_name":"Kevin"},{"last_name":"Belalcázar","first_name":"Luis Carlos","full_name":"Belalcázar, Luis Carlos"},{"last_name":"Lopez-Barrera","full_name":"Lopez-Barrera, Ellie Anne","first_name":"Ellie Anne"},{"id":"92081129-2d75-11ef-a48d-b04dd7a2385a","full_name":"Casallas Garcia, Alejandro","first_name":"Alejandro","last_name":"Casallas Garcia","orcid":"0000-0002-1988-5035"}],"OA_type":"hybrid","acknowledgement":"The author would like to thank Fundación Universitaria Los Libertadores (Project ID: ING-40-25) for supporting her in this work. And EALB, would like to thank Universidad Sergio Arboleda (Project ID: IN.BG.086.24.015) for supporting her in this work. Open access funding provided by Institute of Science and Technology (IST Austria). The first author was funded by the Fundacion Universitaria Los Libertadores (Project ID: ING-40-25). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101034413289 awarded to AC. EALB was supported by Universidad Sergio Arboleda (Project ID: IN.BG.086.24.015).","doi":"10.1007/s41748-026-01068-9","type":"journal_article","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","title":"Spatio-temporal trends of air pollution in six South American cities","citation":{"ama":"González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas Garcia A. Spatio-temporal trends of air pollution in six South American cities. <i>Earth Systems and Environment</i>. 2026. doi:<a href=\"https://doi.org/10.1007/s41748-026-01068-9\">10.1007/s41748-026-01068-9</a>","chicago":"González, Yuri, Nicolás Malagón, Kevin Benavides, Luis Carlos Belalcázar, Ellie Anne Lopez-Barrera, and Alejandro Casallas Garcia. “Spatio-Temporal Trends of Air Pollution in Six South American Cities.” <i>Earth Systems and Environment</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/s41748-026-01068-9\">https://doi.org/10.1007/s41748-026-01068-9</a>.","apa":"González, Y., Malagón, N., Benavides, K., Belalcázar, L. C., Lopez-Barrera, E. A., &#38; Casallas Garcia, A. (2026). Spatio-temporal trends of air pollution in six South American cities. <i>Earth Systems and Environment</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s41748-026-01068-9\">https://doi.org/10.1007/s41748-026-01068-9</a>","short":"Y. González, N. Malagón, K. Benavides, L.C. Belalcázar, E.A. Lopez-Barrera, A. Casallas Garcia, Earth Systems and Environment (2026).","mla":"González, Yuri, et al. “Spatio-Temporal Trends of Air Pollution in Six South American Cities.” <i>Earth Systems and Environment</i>, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1007/s41748-026-01068-9\">10.1007/s41748-026-01068-9</a>.","ieee":"Y. González, N. Malagón, K. Benavides, L. C. Belalcázar, E. A. Lopez-Barrera, and A. Casallas Garcia, “Spatio-temporal trends of air pollution in six South American cities,” <i>Earth Systems and Environment</i>. Springer Nature, 2026.","ista":"González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas Garcia A. 2026. Spatio-temporal trends of air pollution in six South American cities. Earth Systems and Environment."}}]