[{"OA_place":"publisher","date_published":"2020-10-12T00:00:00Z","day":"12","article_processing_charge":"No","supervisor":[{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","full_name":"Novarino, Gaia","first_name":"Gaia","orcid":"0000-0002-7673-7178"}],"publication_identifier":{"issn":["2663-337X"]},"degree_awarded":"PhD","publisher":"Institute of Science and Technology Austria","alternative_title":["ISTA Thesis"],"department":[{"_id":"GaNo"}],"citation":{"apa":"Morandell, J. (2020). <i>Illuminating the role of Cul3 in autism spectrum disorder pathogenesis</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8620\">https://doi.org/10.15479/AT:ISTA:8620</a>","chicago":"Morandell, Jasmin. “Illuminating the Role of Cul3 in Autism Spectrum Disorder Pathogenesis.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8620\">https://doi.org/10.15479/AT:ISTA:8620</a>.","ieee":"J. Morandell, “Illuminating the role of Cul3 in autism spectrum disorder pathogenesis,” Institute of Science and Technology Austria, 2020.","ista":"Morandell J. 2020. Illuminating the role of Cul3 in autism spectrum disorder pathogenesis. Institute of Science and Technology Austria.","mla":"Morandell, Jasmin. <i>Illuminating the Role of Cul3 in Autism Spectrum Disorder Pathogenesis</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8620\">10.15479/AT:ISTA:8620</a>.","short":"J. Morandell, Illuminating the Role of Cul3 in Autism Spectrum Disorder Pathogenesis, Institute of Science and Technology Austria, 2020.","ama":"Morandell J. Illuminating the role of Cul3 in autism spectrum disorder pathogenesis. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8620\">10.15479/AT:ISTA:8620</a>"},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","corr_author":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"acknowledgement":"I would like to especially thank Armel Nicolas from the Proteomics and Christoph Sommer from the Bioimaging Facilities for the data analysis, and to thank the team of the Preclinical Facility, especially Sabina Deixler, Angela Schlerka, Anita Lepold, Mihalea Mihai and Michael Schun for taking care of the mouse line maintenance and their great support.","has_accepted_license":"1","doi":"10.15479/AT:ISTA:8620","oa":1,"type":"dissertation","file_date_updated":"2021-10-16T22:30:04Z","month":"10","author":[{"last_name":"Morandell","id":"4739D480-F248-11E8-B48F-1D18A9856A87","first_name":"Jasmin","full_name":"Morandell, Jasmin"}],"publication_status":"published","date_updated":"2026-04-14T09:07:16Z","ddc":["610"],"status":"public","file":[{"creator":"jmorande","file_id":"8621","content_type":"application/pdf","embargo":"2021-10-15","access_level":"open_access","relation":"main_file","file_name":"Jasmin_Morandell_Thesis-2020_final.pdf","file_size":16155786,"checksum":"7ee83e42de3e5ce2fedb44dff472f75f","date_created":"2020-10-07T14:41:49Z","date_updated":"2021-10-16T22:30:04Z"},{"date_updated":"2021-10-16T22:30:04Z","embargo_to":"open_access","date_created":"2020-10-07T14:45:07Z","checksum":"5e0464af453734210ce7aab7b4a92e3a","file_size":24344152,"file_name":"Jasmin_Morandell_Thesis-2020_final.zip","relation":"source_file","content_type":"application/x-zip-compressed","access_level":"closed","file_id":"8622","creator":"jmorande"}],"title":"Illuminating the role of Cul3 in autism spectrum disorder pathogenesis","language":[{"iso":"eng"}],"_id":"8620","oa_version":"Published Version","related_material":{"record":[{"status":"public","id":"7800","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"8131","status":"public"}]},"date_created":"2020-10-07T14:53:13Z","year":"2020","project":[{"call_identifier":"FWF","name":"Molecular Drug Targets","_id":"2548AE96-B435-11E9-9278-68D0E5697425","grant_number":"W1232"},{"name":"Stem Cell Modulation in Neural Development and Regeneration/ P07-Neural stem cells in autism and epilepsy","_id":"05A0D778-7A3F-11EA-A408-12923DDC885E","grant_number":"F7807"}],"page":"138","abstract":[{"text":"The development of the human brain occurs through a tightly regulated series of dynamic and adaptive processes during prenatal and postnatal life. A disruption of this strictly orchestrated series of events can lead to a number of neurodevelopmental conditions, including Autism Spectrum Disorders (ASDs). ASDs are a very common, etiologically and phenotypically heterogeneous group of disorders sharing the core symptoms of social interaction and communication deficits and restrictive and repetitive interests and behaviors. They are estimated to affect one in 59 individuals in the U.S. and, over the last three decades, mutations in more than a hundred genetic loci have been convincingly linked to ASD pathogenesis. Yet, for the vast majority of these ASD-risk genes their role during brain development and precise molecular function still remain elusive.\r\nDe novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin 3 (CUL3) lead to ASD. In the study described here, we used Cul3 mouse models to evaluate the consequences of Cul3 mutations in vivo. Our results show that Cul3 heterozygous knockout mice exhibit deficits in motor coordination as well as ASD-relevant social and cognitive impairments. Cul3+/-, Cul3+/fl Emx1-Cre and Cul3fl/fl Emx1-Cre mutant brains display cortical lamination abnormalities due to defective migration of post-mitotic excitatory neurons, as well as reduced numbers of excitatory and inhibitory neurons. In line with the observed abnormal cortical organization, Cul3 heterozygous deletion is associated with decreased spontaneous excitatory and inhibitory activity in the cortex. At the molecular level we show that Cul3 regulates cytoskeletal and adhesion protein abundance in the mouse embryonic cortex. Abnormal regulation of cytoskeletal proteins in Cul3 mutant neural cells results in atypical organization of the actin mesh at the cell leading edge. Of note, heterozygous deletion of Cul3 in adult mice does not induce the majority of the behavioral defects observed in constitutive Cul3 haploinsufficient animals, pointing to a critical time-window for Cul3 deficiency.\r\nIn conclusion, our data indicate that Cul3 plays a critical role in the regulation of cytoskeletal proteins and neuronal migration. ASD-associated defects and behavioral abnormalities are primarily due to dosage sensitive Cul3 functions at early brain developmental stages.","lang":"eng"}]},{"author":[{"id":"4739D480-F248-11E8-B48F-1D18A9856A87","last_name":"Morandell","full_name":"Morandell, Jasmin","first_name":"Jasmin"},{"full_name":"Schwarz, Lena A","first_name":"Lena A","last_name":"Schwarz","id":"29A8453C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Basilico, Bernadette","orcid":"0000-0003-1843-3173","first_name":"Bernadette","last_name":"Basilico","id":"36035796-5ACA-11E9-A75E-7AF2E5697425"},{"full_name":"Tasciyan, Saren","orcid":"0000-0003-1671-393X","first_name":"Saren","last_name":"Tasciyan","id":"4323B49C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Armel","full_name":"Nicolas, Armel","id":"2A103192-F248-11E8-B48F-1D18A9856A87","last_name":"Nicolas"},{"id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","last_name":"Sommer","first_name":"Christoph M","orcid":"0000-0003-1216-9105","full_name":"Sommer, Christoph M"},{"full_name":"Kreuzinger, Caroline","first_name":"Caroline","id":"382077BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kreuzinger"},{"first_name":"Lisa","full_name":"Knaus, Lisa","id":"3B2ABCF4-F248-11E8-B48F-1D18A9856A87","last_name":"Knaus"},{"id":"D23090A2-9057-11EA-883A-A8396FC7A38F","last_name":"Dobler","first_name":"Zoe","full_name":"Dobler, Zoe"},{"full_name":"Cacci, Emanuele","first_name":"Emanuele","last_name":"Cacci"},{"last_name":"Danzl","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973","first_name":"Johann G","full_name":"Danzl, Johann G"},{"orcid":"0000-0002-7673-7178","first_name":"Gaia","full_name":"Novarino, Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"}],"month":"01","date_updated":"2026-05-15T22:31:08Z","publication_status":"draft","ddc":["570"],"title":"Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development","status":"public","file":[{"checksum":"c6799ab5daba80efe8e2ed63c15f8c81","file_size":2931370,"date_created":"2020-05-05T14:31:19Z","date_updated":"2020-07-14T12:48:03Z","creator":"rsix","file_id":"7801","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_name":"2020.01.10.902064v1.full.pdf"}],"publication":"bioRxiv","language":[{"iso":"eng"}],"_id":"7800","oa_version":"Preprint","related_material":{"record":[{"status":"public","id":"9429","relation":"later_version"},{"relation":"dissertation_contains","id":"8620","status":"public"}]},"date_created":"2020-05-05T14:31:33Z","project":[{"call_identifier":"FWF","name":"Optical control of synaptic function via adhesion molecules","_id":"265CB4D0-B435-11E9-9278-68D0E5697425","grant_number":"I03600"},{"name":"Molecular Drug Targets","call_identifier":"FWF","_id":"2548AE96-B435-11E9-9278-68D0E5697425","grant_number":"W1232"}],"year":"2020","abstract":[{"text":"De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 (CUL3) lead to autism spectrum disorder (ASD). Here, we used Cul3 mouse models to evaluate the consequences of Cul3 mutations in vivo. Our results show that Cul3 haploinsufficient mice exhibit deficits in motor coordination as well as ASD-relevant social and cognitive impairments. Cul3 mutant brain displays cortical lamination abnormalities due to defective neuronal migration and reduced numbers of excitatory and inhibitory neurons. In line with the observed abnormal columnar organization, Cul3 haploinsufficiency is associated with decreased spontaneous excitatory and inhibitory activity in the cortex. At the molecular level, employing a quantitative proteomic approach, we show that Cul3 regulates cytoskeletal and adhesion protein abundance in mouse embryos. Abnormal regulation of cytoskeletal proteins in Cul3 mutant neuronal cells results in atypical organization of the actin mesh at the cell leading edge, likely causing the observed migration deficits. In contrast to these important functions early in development, Cul3 deficiency appears less relevant at adult stages. In fact, induction of Cul3 haploinsufficiency in adult mice does not result in the behavioral defects observed in constitutive Cul3 haploinsufficient animals. Taken together, our data indicate that Cul3 has a critical role in the regulation of cytoskeletal proteins and neuronal migration and that ASD-associated defects and behavioral abnormalities are primarily due to Cul3 functions at early developmental stages.","lang":"eng"}],"date_published":"2020-01-11T00:00:00Z","day":"11","article_processing_charge":"No","department":[{"_id":"JoDa"},{"_id":"GaNo"},{"_id":"LifeSc"}],"citation":{"ama":"Morandell J, Schwarz LA, Basilico B, et al. Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2020.01.10.902064 \">10.1101/2020.01.10.902064 </a>","short":"J. Morandell, L.A. Schwarz, B. Basilico, S. Tasciyan, A. Nicolas, C.M. Sommer, C. Kreuzinger, L. Knaus, Z. Dobler, E. Cacci, J.G. Danzl, G. Novarino, BioRxiv (n.d.).","mla":"Morandell, Jasmin, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis and Cell Migration during a Critical Window of Brain Development.” <i>BioRxiv</i>, Cold Spring Harbor Laboratory, doi:<a href=\"https://doi.org/10.1101/2020.01.10.902064 \">10.1101/2020.01.10.902064 </a>.","ista":"Morandell J, Schwarz LA, Basilico B, Tasciyan S, Nicolas A, Sommer CM, Kreuzinger C, Knaus L, Dobler Z, Cacci E, Danzl JG, Novarino G. Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. bioRxiv, <a href=\"https://doi.org/10.1101/2020.01.10.902064 \">10.1101/2020.01.10.902064 </a>.","apa":"Morandell, J., Schwarz, L. A., Basilico, B., Tasciyan, S., Nicolas, A., Sommer, C. M., … Novarino, G. (n.d.). Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. <i>bioRxiv</i>. Cold Spring Harbor Laboratory. <a href=\"https://doi.org/10.1101/2020.01.10.902064 \">https://doi.org/10.1101/2020.01.10.902064 </a>","chicago":"Morandell, Jasmin, Lena A Schwarz, Bernadette Basilico, Saren Tasciyan, Armel Nicolas, Christoph M Sommer, Caroline Kreuzinger, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis and Cell Migration during a Critical Window of Brain Development.” <i>BioRxiv</i>. Cold Spring Harbor Laboratory, n.d. <a href=\"https://doi.org/10.1101/2020.01.10.902064 \">https://doi.org/10.1101/2020.01.10.902064 </a>.","ieee":"J. Morandell <i>et al.</i>, “Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development,” <i>bioRxiv</i>. Cold Spring Harbor Laboratory."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Cold Spring Harbor Laboratory","acknowledged_ssus":[{"_id":"PreCl"}],"corr_author":"1","tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"has_accepted_license":"1","doi":"10.1101/2020.01.10.902064 ","oa":1,"file_date_updated":"2020-07-14T12:48:03Z","type":"preprint"},{"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"article_processing_charge":"No","publisher":"Springer Nature","department":[{"_id":"NanoFab"},{"_id":"Bio"},{"_id":"MiSi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Reversat A, Gärtner FR, Merrin J, et al. Cellular locomotion using environmental topography. <i>Nature</i>. 2020;582:582–585. doi:<a href=\"https://doi.org/10.1038/s41586-020-2283-z\">10.1038/s41586-020-2283-z</a>","short":"A. Reversat, F.R. Gärtner, J. Merrin, J.A. Stopp, S. Tasciyan, J.L. Aguilera Servin, I. de Vries, R. Hauschild, M. Hons, M. Piel, A. Callan-Jones, R. Voituriez, M.K. Sixt, Nature 582 (2020) 582–585.","mla":"Reversat, Anne, et al. “Cellular Locomotion Using Environmental Topography.” <i>Nature</i>, vol. 582, Springer Nature, 2020, pp. 582–585, doi:<a href=\"https://doi.org/10.1038/s41586-020-2283-z\">10.1038/s41586-020-2283-z</a>.","ista":"Reversat A, Gärtner FR, Merrin J, Stopp JA, Tasciyan S, Aguilera Servin JL, de Vries I, Hauschild R, Hons M, Piel M, Callan-Jones A, Voituriez R, Sixt MK. 2020. Cellular locomotion using environmental topography. Nature. 582, 582–585.","ieee":"A. Reversat <i>et al.</i>, “Cellular locomotion using environmental topography,” <i>Nature</i>, vol. 582. Springer Nature, pp. 582–585, 2020.","chicago":"Reversat, Anne, Florian R Gärtner, Jack Merrin, Julian A Stopp, Saren Tasciyan, Juan L Aguilera Servin, Ingrid de Vries, et al. “Cellular Locomotion Using Environmental Topography.” <i>Nature</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41586-020-2283-z\">https://doi.org/10.1038/s41586-020-2283-z</a>.","apa":"Reversat, A., Gärtner, F. R., Merrin, J., Stopp, J. A., Tasciyan, S., Aguilera Servin, J. L., … Sixt, M. K. (2020). Cellular locomotion using environmental topography. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-020-2283-z\">https://doi.org/10.1038/s41586-020-2283-z</a>"},"date_published":"2020-06-25T00:00:00Z","OA_place":"repository","intvolume":"       582","day":"25","quality_controlled":"1","oa":1,"doi":"10.1038/s41586-020-2283-z","main_file_link":[{"url":"https://doi.org/10.1101/793919","open_access":"1"}],"type":"journal_article","pmid":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"M-Shop"}],"acknowledgement":"We thank A. Leithner and J. Renkawitz for discussion and critical reading of the manuscript; J. Schwarz and M. Mehling for establishing the microfluidic setups; the Bioimaging Facility of IST Austria for excellent support, as well as the Life Science Facility and the Miba Machine Shop of IST Austria; and F. N. Arslan, L. E. Burnett and L. Li for their work during their rotation in the IST PhD programme. This work was supported by the European Research Council (ERC StG 281556 and CoG 724373) to M.S. and grants from the Austrian Science Fund (FWF P29911) and the WWTF to M.S. M.H. was supported by the European Regional Development Fund Project (CZ.02.1.01/0.0/0.0/15_003/0000476). F.G. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 747687.","article_type":"original","status":"public","scopus_import":"1","title":"Cellular locomotion using environmental topography","_id":"7885","publication":"Nature","language":[{"iso":"eng"}],"author":[{"last_name":"Reversat","id":"35B76592-F248-11E8-B48F-1D18A9856A87","full_name":"Reversat, Anne","orcid":"0000-0003-0666-8928","first_name":"Anne"},{"full_name":"Gärtner, Florian R","orcid":"0000-0001-6120-3723","first_name":"Florian R","last_name":"Gärtner","id":"397A88EE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Merrin","id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack","orcid":"0000-0001-5145-4609","first_name":"Jack"},{"last_name":"Stopp","id":"489E3F00-F248-11E8-B48F-1D18A9856A87","first_name":"Julian A","full_name":"Stopp, Julian A"},{"full_name":"Tasciyan, Saren","orcid":"0000-0003-1671-393X","first_name":"Saren","last_name":"Tasciyan","id":"4323B49C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Aguilera Servin, Juan L","first_name":"Juan L","orcid":"0000-0002-2862-8372","id":"2A67C376-F248-11E8-B48F-1D18A9856A87","last_name":"Aguilera Servin"},{"first_name":"Ingrid","full_name":"De Vries, Ingrid","last_name":"De Vries","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87"},{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","last_name":"Hauschild","first_name":"Robert","orcid":"0000-0001-9843-3522","full_name":"Hauschild, Robert"},{"first_name":"Miroslav","orcid":"0000-0002-6625-3348","full_name":"Hons, Miroslav","id":"4167FE56-F248-11E8-B48F-1D18A9856A87","last_name":"Hons"},{"full_name":"Piel, Matthieu","first_name":"Matthieu","last_name":"Piel"},{"full_name":"Callan-Jones, Andrew","first_name":"Andrew","last_name":"Callan-Jones"},{"full_name":"Voituriez, Raphael","first_name":"Raphael","last_name":"Voituriez"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K"}],"month":"06","OA_type":"green","publication_status":"published","date_updated":"2026-05-15T22:31:08Z","year":"2020","isi":1,"project":[{"_id":"25A603A2-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Cytoskeletal force generation and force transduction of migrating leukocytes","grant_number":"281556"},{"call_identifier":"H2020","name":"Cellular Navigation Along Spatial Gradients","_id":"25FE9508-B435-11E9-9278-68D0E5697425","grant_number":"724373"},{"grant_number":"P29911","_id":"26018E70-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Mechanical adaptation of lamellipodial actin"},{"call_identifier":"H2020","name":"Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells","_id":"260AA4E2-B435-11E9-9278-68D0E5697425","grant_number":"747687"}],"volume":582,"abstract":[{"text":"Eukaryotic cells migrate by coupling the intracellular force of the actin cytoskeleton to the environment. While force coupling is usually mediated by transmembrane adhesion receptors, especially those of the integrin family, amoeboid cells such as leukocytes can migrate extremely fast despite very low adhesive forces1. Here we show that leukocytes cannot only migrate under low adhesion but can also transmit forces in the complete absence of transmembrane force coupling. When confined within three-dimensional environments, they use the topographical features of the substrate to propel themselves. Here the retrograde flow of the actin cytoskeleton follows the texture of the substrate, creating retrograde shear forces that are sufficient to drive the cell body forwards. Notably, adhesion-dependent and adhesion-independent migration are not mutually exclusive, but rather are variants of the same principle of coupling retrograde actin flow to the environment and thus can potentially operate interchangeably and simultaneously. As adhesion-free migration is independent of the chemical composition of the environment, it renders cells completely autonomous in their locomotive behaviour.","lang":"eng"}],"ec_funded":1,"page":"582–585","oa_version":"Preprint","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/off-road-mode-enables-mobile-cells-to-move-freely/","description":"News on IST Homepage"}],"record":[{"status":"public","relation":"dissertation_contains","id":"14697"},{"id":"12401","relation":"dissertation_contains","status":"public"}]},"date_created":"2020-05-24T22:01:01Z","external_id":{"isi":["000532688300008"],"pmid":["32581372"]}},{"article_processing_charge":"Yes (via OA deal)","publication_identifier":{"eissn":["1879-0380"],"issn":["0959-437X"]},"publisher":"Elsevier","issue":"12","department":[{"_id":"GaNo"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"ama":"Basilico B, Morandell J, Novarino G. Molecular mechanisms for targeted ASD treatments. <i>Current Opinion in Genetics and Development</i>. 2020;65(12):126-137. doi:<a href=\"https://doi.org/10.1016/j.gde.2020.06.004\">10.1016/j.gde.2020.06.004</a>","short":"B. Basilico, J. Morandell, G. Novarino, Current Opinion in Genetics and Development 65 (2020) 126–137.","mla":"Basilico, Bernadette, et al. “Molecular Mechanisms for Targeted ASD Treatments.” <i>Current Opinion in Genetics and Development</i>, vol. 65, no. 12, Elsevier, 2020, pp. 126–37, doi:<a href=\"https://doi.org/10.1016/j.gde.2020.06.004\">10.1016/j.gde.2020.06.004</a>.","apa":"Basilico, B., Morandell, J., &#38; Novarino, G. (2020). Molecular mechanisms for targeted ASD treatments. <i>Current Opinion in Genetics and Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.gde.2020.06.004\">https://doi.org/10.1016/j.gde.2020.06.004</a>","chicago":"Basilico, Bernadette, Jasmin Morandell, and Gaia Novarino. “Molecular Mechanisms for Targeted ASD Treatments.” <i>Current Opinion in Genetics and Development</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.gde.2020.06.004\">https://doi.org/10.1016/j.gde.2020.06.004</a>.","ieee":"B. Basilico, J. Morandell, and G. Novarino, “Molecular mechanisms for targeted ASD treatments,” <i>Current Opinion in Genetics and Development</i>, vol. 65, no. 12. Elsevier, pp. 126–137, 2020.","ista":"Basilico B, Morandell J, Novarino G. 2020. Molecular mechanisms for targeted ASD treatments. Current Opinion in Genetics and Development. 65(12), 126–137."},"intvolume":"        65","date_published":"2020-12-01T00:00:00Z","quality_controlled":"1","day":"01","doi":"10.1016/j.gde.2020.06.004","oa":1,"type":"journal_article","pmid":1,"file_date_updated":"2020-07-22T06:47:45Z","corr_author":"1","tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"has_accepted_license":"1","scopus_import":"1","status":"public","file":[{"creator":"dernst","file_id":"8146","file_name":"2020_CurrentOpGenetics_Basilico.pdf","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_size":1381545,"date_updated":"2020-07-22T06:47:45Z","success":1,"date_created":"2020-07-22T06:47:45Z"}],"title":"Molecular mechanisms for targeted ASD treatments","article_type":"original","publication":"Current Opinion in Genetics and Development","language":[{"iso":"eng"}],"_id":"8131","month":"12","author":[{"full_name":"Basilico, Bernadette","orcid":"0000-0003-1843-3173","first_name":"Bernadette","last_name":"Basilico","id":"36035796-5ACA-11E9-A75E-7AF2E5697425"},{"first_name":"Jasmin","full_name":"Morandell, Jasmin","last_name":"Morandell","id":"4739D480-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","first_name":"Gaia"}],"publication_status":"published","date_updated":"2026-05-15T22:31:08Z","ddc":["570"],"year":"2020","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","name":"Molecular Drug Targets","_id":"2548AE96-B435-11E9-9278-68D0E5697425","grant_number":"W1232"},{"_id":"05A0D778-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P07-Neural stem cells in autism and epilepsy","grant_number":"F7807"}],"isi":1,"volume":65,"page":"126-137","ec_funded":1,"abstract":[{"lang":"eng","text":"The possibility to generate construct valid animal models enabled the development and testing of therapeutic strategies targeting the core features of autism spectrum disorders (ASDs). At the same time, these studies highlighted the necessity of identifying sensitive developmental time windows for successful therapeutic interventions. Animal and human studies also uncovered the possibility to stratify the variety of ASDs in molecularly distinct subgroups, potentially facilitating effective treatment design. Here, we focus on the molecular pathways emerging as commonly affected by mutations in diverse ASD-risk genes, on their role during critical windows of brain development and the potential treatments targeting these biological processes."}],"oa_version":"Published Version","related_material":{"record":[{"relation":"dissertation_contains","id":"8620","status":"public"}]},"date_created":"2020-07-19T22:00:58Z","external_id":{"isi":["000598918900019"],"pmid":["32659636"]}},{"oa_version":"Published Version","external_id":{"isi":["000546406600043"],"pmid":["32449730"]},"date_created":"2020-05-11T08:31:20Z","related_material":{"record":[{"status":"public","id":"7902","relation":"part_of_dissertation"}]},"year":"2020","isi":1,"project":[{"call_identifier":"FWF","name":"Molecular Mechanisms Regulating Gliogenesis in the Neocortex","_id":"264E56E2-B435-11E9-9278-68D0E5697425","grant_number":"M02416"},{"grant_number":"T01031","call_identifier":"FWF","name":"Role of Eed in neural stem cell lineage progression","_id":"268F8446-B435-11E9-9278-68D0E5697425"},{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"},{"grant_number":"24812","_id":"2625A13E-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of radial neuronal migration"},{"grant_number":"725780","_id":"260018B0-B435-11E9-9278-68D0E5697425","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","call_identifier":"H2020"}],"ec_funded":1,"abstract":[{"lang":"eng","text":"Beginning from a limited pool of progenitors, the mammalian cerebral cortex forms highly organized functional neural circuits. However, the underlying cellular and molecular mechanisms regulating lineage transitions of neural stem cells (NSCs) and eventual production of neurons and glia in the developing neuroepithelium remains unclear. Methods to trace NSC division patterns and map the lineage of clonally related cells have advanced dramatically. However, many contemporary lineage tracing techniques suffer from the lack of cellular resolution of progeny cell fate, which is essential for deciphering progenitor cell division patterns. Presented is a protocol using mosaic analysis with double markers (MADM) to perform in vivo clonal analysis. MADM concomitantly manipulates individual progenitor cells and visualizes precise division patterns and lineage progression at unprecedented single cell resolution. MADM-based interchromosomal recombination events during the G2-X phase of mitosis, together with temporally inducible CreERT2, provide exact information on the birth dates of clones and their division patterns. Thus, MADM lineage tracing provides unprecedented qualitative and quantitative optical readouts of the proliferation mode of stem cell progenitors at the single cell level. MADM also allows for examination of the mechanisms and functional requirements of candidate genes in NSC lineage progression. This method is unique in that comparative analysis of control and mutant subclones can be performed in the same tissue environment in vivo. Here, the protocol is described in detail, and experimental paradigms to employ MADM for clonal analysis and lineage tracing in the developing cerebral cortex are demonstrated. Importantly, this protocol can be adapted to perform MADM clonal analysis in any murine stem cell niche, as long as the CreERT2 driver is present."}],"month":"05","author":[{"id":"2E26DF60-F248-11E8-B48F-1D18A9856A87","last_name":"Beattie","first_name":"Robert J","orcid":"0000-0002-8483-8753","full_name":"Beattie, Robert J"},{"first_name":"Carmen","full_name":"Streicher, Carmen","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","last_name":"Streicher"},{"full_name":"Amberg, Nicole","orcid":"0000-0002-3183-8207","first_name":"Nicole","last_name":"Amberg","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87"},{"id":"471195F6-F248-11E8-B48F-1D18A9856A87","last_name":"Cheung","first_name":"Giselle T","orcid":"0000-0001-8457-2572","full_name":"Cheung, Giselle T"},{"id":"475990FE-F248-11E8-B48F-1D18A9856A87","last_name":"Contreras","full_name":"Contreras, Ximena","first_name":"Ximena"},{"first_name":"Andi H","full_name":"Hansen, Andi H","last_name":"Hansen","id":"38853E16-F248-11E8-B48F-1D18A9856A87"},{"id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","full_name":"Hippenmeyer, Simon","first_name":"Simon","orcid":"0000-0003-2279-1061"}],"ddc":["570"],"publication_status":"published","date_updated":"2026-05-15T22:31:12Z","article_type":"original","scopus_import":"1","status":"public","file":[{"date_updated":"2020-07-14T12:48:03Z","date_created":"2020-05-11T08:28:38Z","file_size":1352186,"checksum":"3154ea7f90b9fb45e084cd1c2770597d","file_name":"jove-protocol-61147-lineage-tracing-clonal-analysis-developing-cerebral-cortex-using.pdf","relation":"main_file","content_type":"application/pdf","access_level":"open_access","file_id":"7816","creator":"rbeattie"}],"title":"Lineage tracing and clonal analysis in developing cerebral cortex using mosaic analysis with double markers (MADM)","_id":"7815","publication":"Journal of Visual Experiments","language":[{"iso":"eng"}],"corr_author":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"PreCl"}],"has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_number":"e61147","oa":1,"doi":"10.3791/61147","type":"journal_article","pmid":1,"file_date_updated":"2020-07-14T12:48:03Z","date_published":"2020-05-08T00:00:00Z","day":"08","quality_controlled":"1","publication_identifier":{"issn":["1940-087X"]},"article_processing_charge":"No","issue":"159","publisher":"MyJove Corporation","department":[{"_id":"SiHi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Beattie RJ, Streicher C, Amberg N, Cheung GT, Contreras X, Hansen AH, Hippenmeyer S. 2020. Lineage tracing and clonal analysis in developing cerebral cortex using mosaic analysis with double markers (MADM). Journal of Visual Experiments. (159), e61147.","ieee":"R. J. Beattie <i>et al.</i>, “Lineage tracing and clonal analysis in developing cerebral cortex using mosaic analysis with double markers (MADM),” <i>Journal of Visual Experiments</i>, no. 159. MyJove Corporation, 2020.","chicago":"Beattie, Robert J, Carmen Streicher, Nicole Amberg, Giselle T Cheung, Ximena Contreras, Andi H Hansen, and Simon Hippenmeyer. “Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM).” <i>Journal of Visual Experiments</i>. MyJove Corporation, 2020. <a href=\"https://doi.org/10.3791/61147\">https://doi.org/10.3791/61147</a>.","apa":"Beattie, R. J., Streicher, C., Amberg, N., Cheung, G. T., Contreras, X., Hansen, A. H., &#38; Hippenmeyer, S. (2020). Lineage tracing and clonal analysis in developing cerebral cortex using mosaic analysis with double markers (MADM). <i>Journal of Visual Experiments</i>. MyJove Corporation. <a href=\"https://doi.org/10.3791/61147\">https://doi.org/10.3791/61147</a>","mla":"Beattie, Robert J., et al. “Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM).” <i>Journal of Visual Experiments</i>, no. 159, e61147, MyJove Corporation, 2020, doi:<a href=\"https://doi.org/10.3791/61147\">10.3791/61147</a>.","short":"R.J. Beattie, C. Streicher, N. Amberg, G.T. Cheung, X. Contreras, A.H. Hansen, S. Hippenmeyer, Journal of Visual Experiments (2020).","ama":"Beattie RJ, Streicher C, Amberg N, et al. Lineage tracing and clonal analysis in developing cerebral cortex using mosaic analysis with double markers (MADM). <i>Journal of Visual Experiments</i>. 2020;(159). doi:<a href=\"https://doi.org/10.3791/61147\">10.3791/61147</a>"}},{"publisher":"Institute of Science and Technology Austria","department":[{"_id":"SiHi"}],"alternative_title":["ISTA Thesis"],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"ista":"Contreras X. 2020. Genetic dissection of neural development in health and disease at single cell resolution. Institute of Science and Technology Austria.","chicago":"Contreras, Ximena. “Genetic Dissection of Neural Development in Health and Disease at Single Cell Resolution.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:7902\">https://doi.org/10.15479/AT:ISTA:7902</a>.","ieee":"X. Contreras, “Genetic dissection of neural development in health and disease at single cell resolution,” Institute of Science and Technology Austria, 2020.","apa":"Contreras, X. (2020). <i>Genetic dissection of neural development in health and disease at single cell resolution</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:7902\">https://doi.org/10.15479/AT:ISTA:7902</a>","mla":"Contreras, Ximena. <i>Genetic Dissection of Neural Development in Health and Disease at Single Cell Resolution</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7902\">10.15479/AT:ISTA:7902</a>.","short":"X. Contreras, Genetic Dissection of Neural Development in Health and Disease at Single Cell Resolution, Institute of Science and Technology Austria, 2020.","ama":"Contreras X. Genetic dissection of neural development in health and disease at single cell resolution. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7902\">10.15479/AT:ISTA:7902</a>"},"degree_awarded":"PhD","publication_identifier":{"issn":["2663-337X"]},"article_processing_charge":"No","supervisor":[{"last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","first_name":"Simon"}],"day":"05","date_published":"2020-06-05T00:00:00Z","OA_place":"publisher","type":"dissertation","file_date_updated":"2021-06-07T22:30:03Z","oa":1,"doi":"10.15479/AT:ISTA:7902","has_accepted_license":"1","corr_author":"1","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"}],"_id":"7902","language":[{"iso":"eng"}],"file":[{"creator":"xcontreras","file_id":"7927","file_name":"PhDThesis_Contreras.docx","access_level":"closed","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","relation":"source_file","checksum":"43c172bf006c95b65992d473c7240d13","file_size":53134142,"date_updated":"2021-06-07T22:30:03Z","date_created":"2020-06-05T08:18:08Z","embargo_to":"open_access"},{"checksum":"addfed9128271be05cae3608e03a6ec0","file_size":35117191,"date_updated":"2021-06-07T22:30:03Z","date_created":"2020-06-05T08:18:07Z","creator":"xcontreras","file_id":"7928","file_name":"PhDThesis_Contreras.pdf","content_type":"application/pdf","embargo":"2021-06-06","access_level":"open_access","relation":"main_file"}],"status":"public","title":"Genetic dissection of neural development in health and disease at single cell resolution","ddc":["570"],"publication_status":"published","date_updated":"2026-04-16T09:52:49Z","author":[{"id":"475990FE-F248-11E8-B48F-1D18A9856A87","last_name":"Contreras","full_name":"Contreras, Ximena","first_name":"Ximena"}],"month":"06","ec_funded":1,"abstract":[{"text":"Mosaic genetic analysis has been widely used in different model organisms such as the fruit fly to study gene-function in a cell-autonomous or tissue-specific fashion. More recently, and less easily conducted, mosaic genetic analysis in mice has also been enabled with the ambition to shed light on human gene function and disease. These genetic tools are of particular interest, but not restricted to, the study of the brain. Notably, the MADM technology offers a genetic approach in mice to visualize and concomitantly manipulate small subsets of genetically defined cells at a clonal level and single cell resolution. MADM-based analysis has already advanced the study of genetic mechanisms regulating brain development and is expected that further MADM-based analysis of genetic alterations will continue to reveal important insights on the fundamental principles of development and disease to potentially assist in the development of new therapies or treatments.\r\nIn summary, this work completed and characterized the necessary genome-wide genetic tools to perform MADM-based analysis at single cell level of the vast majority of mouse genes in virtually any cell type and provided a protocol to perform lineage tracing using the novel MADM resource. Importantly, this work also explored and revealed novel aspects of biologically relevant events in an in vivo context, such as the chromosome-specific bias of chromatid sister segregation pattern, the generation of cell-type diversity in the cerebral cortex and in the cerebellum and finally, the relevance of the interplay between the cell-autonomous gene function and cell-non-autonomous (community) effects in radial glial progenitor lineage progression.\r\nThis work provides a foundation and opens the door to further elucidating the molecular mechanisms underlying neuronal diversity and astrocyte generation.","lang":"eng"}],"page":"214","year":"2020","project":[{"_id":"260018B0-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780"}],"date_created":"2020-05-29T08:27:32Z","related_material":{"record":[{"id":"28","relation":"dissertation_contains","status":"public"},{"status":"public","id":"7815","relation":"dissertation_contains"},{"id":"6830","relation":"dissertation_contains","status":"public"}]},"oa_version":"Published Version"},{"intvolume":"     12075","date_published":"2020-04-18T00:00:00Z","quality_controlled":"1","day":"18","article_processing_charge":"No","publication_identifier":{"eissn":["1611-3349"],"isbn":["9783030449131"],"issn":["0302-9743"]},"publisher":"Springer Nature","alternative_title":["LNCS"],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"short":"K. Chatterjee, A.K. Goharshady, R. Ibsen-Jensen, A. Pavlogiannis, in:, European Symposium on Programming, Springer Nature, 2020, pp. 112–140.","ama":"Chatterjee K, Goharshady AK, Ibsen-Jensen R, Pavlogiannis A. Optimal and perfectly parallel algorithms for on-demand data-flow analysis. In: <i>European Symposium on Programming</i>. Vol 12075. Springer Nature; 2020:112-140. doi:<a href=\"https://doi.org/10.1007/978-3-030-44914-8_5\">10.1007/978-3-030-44914-8_5</a>","ista":"Chatterjee K, Goharshady AK, Ibsen-Jensen R, Pavlogiannis A. 2020. Optimal and perfectly parallel algorithms for on-demand data-flow analysis. European Symposium on Programming. ESOP: Programming Languages and Systems, LNCS, vol. 12075, 112–140.","chicago":"Chatterjee, Krishnendu, Amir Kafshdar Goharshady, Rasmus Ibsen-Jensen, and Andreas Pavlogiannis. “Optimal and Perfectly Parallel Algorithms for On-Demand Data-Flow Analysis.” In <i>European Symposium on Programming</i>, 12075:112–40. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/978-3-030-44914-8_5\">https://doi.org/10.1007/978-3-030-44914-8_5</a>.","apa":"Chatterjee, K., Goharshady, A. K., Ibsen-Jensen, R., &#38; Pavlogiannis, A. (2020). Optimal and perfectly parallel algorithms for on-demand data-flow analysis. In <i>European Symposium on Programming</i> (Vol. 12075, pp. 112–140). Dublin, Ireland: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-44914-8_5\">https://doi.org/10.1007/978-3-030-44914-8_5</a>","ieee":"K. Chatterjee, A. K. Goharshady, R. Ibsen-Jensen, and A. Pavlogiannis, “Optimal and perfectly parallel algorithms for on-demand data-flow analysis,” in <i>European Symposium on Programming</i>, Dublin, Ireland, 2020, vol. 12075, pp. 112–140.","mla":"Chatterjee, Krishnendu, et al. “Optimal and Perfectly Parallel Algorithms for On-Demand Data-Flow Analysis.” <i>European Symposium on Programming</i>, vol. 12075, Springer Nature, 2020, pp. 112–40, doi:<a href=\"https://doi.org/10.1007/978-3-030-44914-8_5\">10.1007/978-3-030-44914-8_5</a>."},"department":[{"_id":"KrCh"}],"corr_author":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","doi":"10.1007/978-3-030-44914-8_5","oa":1,"type":"conference","file_date_updated":"2020-07-14T12:48:03Z","conference":{"name":"ESOP: Programming Languages and Systems","start_date":"2020-04-25","location":"Dublin, Ireland","end_date":"2020-04-30"},"author":[{"orcid":"0000-0002-4561-241X","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Goharshady","id":"391365CE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1702-6584","first_name":"Amir Kafshdar","full_name":"Goharshady, Amir Kafshdar"},{"last_name":"Ibsen-Jensen","id":"3B699956-F248-11E8-B48F-1D18A9856A87","full_name":"Ibsen-Jensen, Rasmus","orcid":"0000-0003-4783-0389","first_name":"Rasmus"},{"orcid":"0000-0002-8943-0722","first_name":"Andreas","full_name":"Pavlogiannis, Andreas","last_name":"Pavlogiannis","id":"49704004-F248-11E8-B48F-1D18A9856A87"}],"month":"04","publication_status":"published","date_updated":"2026-05-15T22:31:17Z","ddc":["000"],"status":"public","scopus_import":"1","file":[{"relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_name":"2020_LNCS_Chatterjee.pdf","file_id":"7895","creator":"dernst","date_created":"2020-05-26T13:34:48Z","date_updated":"2020-07-14T12:48:03Z","checksum":"8618b80f4cf7b39a60e61a6445ad9807","file_size":651250}],"title":"Optimal and perfectly parallel algorithms for on-demand data-flow analysis","publication":"European Symposium on Programming","language":[{"iso":"eng"}],"_id":"7810","oa_version":"Published Version","date_created":"2020-05-10T22:00:50Z","external_id":{"isi":["000681656800005"]},"related_material":{"record":[{"id":"8934","relation":"dissertation_contains","status":"public"}]},"year":"2020","volume":12075,"isi":1,"project":[{"call_identifier":"FWF","name":"Rigorous Systems Engineering","_id":"25832EC2-B435-11E9-9278-68D0E5697425","grant_number":"S 11407_N23"},{"grant_number":"ICT15-003","name":"Efficient Algorithms for Computer Aided Verification","_id":"25892FC0-B435-11E9-9278-68D0E5697425"},{"name":"Quantitative Game-theoretic Analysis of Blockchain Applications and Smart Contracts","_id":"266EEEC0-B435-11E9-9278-68D0E5697425"},{"_id":"267066CE-B435-11E9-9278-68D0E5697425","name":"Quantitative Analysis of Probabilistic Systems with a focus on Crypto-Currencies"}],"page":"112-140","abstract":[{"lang":"eng","text":"Interprocedural data-flow analyses form an expressive and useful paradigm of numerous static analysis applications, such as live variables analysis, alias analysis and null pointers analysis. The most widely-used framework for interprocedural data-flow analysis is IFDS, which encompasses distributive data-flow functions over a finite domain. On-demand data-flow analyses restrict the focus of the analysis on specific program locations and data facts. This setting provides a natural split between (i) an offline (or preprocessing) phase, where the program is partially analyzed and analysis summaries are created, and (ii) an online (or query) phase, where analysis queries arrive on demand and the summaries are used to speed up answering queries.\r\nIn this work, we consider on-demand IFDS analyses where the queries concern program locations of the same procedure (aka same-context queries). We exploit the fact that flow graphs of programs have low treewidth to develop faster algorithms that are space and time optimal for many common data-flow analyses, in both the preprocessing and the query phase. We also use treewidth to develop query solutions that are embarrassingly parallelizable, i.e. the total work for answering each query is split to a number of threads such that each thread performs only a constant amount of work. Finally, we implement a static analyzer based on our algorithms, and perform a series of on-demand analysis experiments on standard benchmarks. Our experimental results show a drastic speed-up of the queries after only a lightweight preprocessing phase, which significantly outperforms existing techniques."}]},{"has_accepted_license":"1","conference":{"end_date":"2020-10-23","location":"Hanoi, Vietnam","start_date":"2020-10-19","name":"ATVA: Automated Technology for Verification and Analysis"},"file_date_updated":"2020-11-06T07:41:03Z","type":"conference","oa":1,"doi":"10.1007/978-3-030-59152-6_14","day":"12","quality_controlled":"1","date_published":"2020-10-12T00:00:00Z","intvolume":"     12302","department":[{"_id":"KrCh"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","alternative_title":["LNCS"],"citation":{"ama":"Asadi A, Chatterjee K, Goharshady AK, Mohammadi K, Pavlogiannis A. Faster algorithms for quantitative analysis of MCs and MDPs with small treewidth. In: <i>Automated Technology for Verification and Analysis</i>. Vol 12302. Springer Nature; 2020:253-270. doi:<a href=\"https://doi.org/10.1007/978-3-030-59152-6_14\">10.1007/978-3-030-59152-6_14</a>","short":"A. Asadi, K. Chatterjee, A.K. Goharshady, K. Mohammadi, A. Pavlogiannis, in:, Automated Technology for Verification and Analysis, Springer Nature, 2020, pp. 253–270.","mla":"Asadi, Ali, et al. “Faster Algorithms for Quantitative Analysis of MCs and MDPs with Small Treewidth.” <i>Automated Technology for Verification and Analysis</i>, vol. 12302, Springer Nature, 2020, pp. 253–70, doi:<a href=\"https://doi.org/10.1007/978-3-030-59152-6_14\">10.1007/978-3-030-59152-6_14</a>.","ieee":"A. Asadi, K. Chatterjee, A. K. Goharshady, K. Mohammadi, and A. Pavlogiannis, “Faster algorithms for quantitative analysis of MCs and MDPs with small treewidth,” in <i>Automated Technology for Verification and Analysis</i>, Hanoi, Vietnam, 2020, vol. 12302, pp. 253–270.","apa":"Asadi, A., Chatterjee, K., Goharshady, A. K., Mohammadi, K., &#38; Pavlogiannis, A. (2020). Faster algorithms for quantitative analysis of MCs and MDPs with small treewidth. In <i>Automated Technology for Verification and Analysis</i> (Vol. 12302, pp. 253–270). Hanoi, Vietnam: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-59152-6_14\">https://doi.org/10.1007/978-3-030-59152-6_14</a>","chicago":"Asadi, Ali, Krishnendu Chatterjee, Amir Kafshdar Goharshady, Kiarash Mohammadi, and Andreas Pavlogiannis. “Faster Algorithms for Quantitative Analysis of MCs and MDPs with Small Treewidth.” In <i>Automated Technology for Verification and Analysis</i>, 12302:253–70. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/978-3-030-59152-6_14\">https://doi.org/10.1007/978-3-030-59152-6_14</a>.","ista":"Asadi A, Chatterjee K, Goharshady AK, Mohammadi K, Pavlogiannis A. 2020. Faster algorithms for quantitative analysis of MCs and MDPs with small treewidth. Automated Technology for Verification and Analysis. ATVA: Automated Technology for Verification and Analysis, LNCS, vol. 12302, 253–270."},"publisher":"Springer Nature","publication_identifier":{"issn":["0302-9743"],"eisbn":["9783030591526"],"isbn":["9783030591519"],"eissn":["1611-3349"]},"article_processing_charge":"No","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"8934"}]},"external_id":{"isi":["000723555700014"]},"date_created":"2020-11-06T07:30:05Z","oa_version":"Submitted Version","abstract":[{"text":"Discrete-time Markov Chains (MCs) and Markov Decision Processes (MDPs) are two standard formalisms in system analysis. Their main associated quantitative objectives are hitting probabilities, discounted sum, and mean payoff. Although there are many techniques for computing these objectives in general MCs/MDPs, they have not been thoroughly studied in terms of parameterized algorithms, particularly when treewidth is used as the parameter. This is in sharp contrast to qualitative objectives for MCs, MDPs and graph games, for which treewidth-based algorithms yield significant complexity improvements. In this work, we show that treewidth can also be used to obtain faster algorithms for the quantitative problems. For an MC with n states and m transitions, we show that each of the classical quantitative objectives can be computed in   O((n+m)⋅t2)  time, given a tree decomposition of the MC with width t. Our results also imply a bound of   O(κ⋅(n+m)⋅t2)  for each objective on MDPs, where   κ  is the number of strategy-iteration refinements required for the given input and objective. Finally, we make an experimental evaluation of our new algorithms on low-treewidth MCs and MDPs obtained from the DaCapo benchmark suite. Our experiments show that on low-treewidth MCs and MDPs, our algorithms outperform existing well-established methods by one or more orders of magnitude.","lang":"eng"}],"page":"253-270","project":[{"grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","call_identifier":"FWF"},{"_id":"25892FC0-B435-11E9-9278-68D0E5697425","name":"Efficient Algorithms for Computer Aided Verification","grant_number":"ICT15-003"},{"_id":"267066CE-B435-11E9-9278-68D0E5697425","name":"Quantitative Analysis of Probabilistic Systems with a focus on Crypto-Currencies"}],"isi":1,"volume":12302,"year":"2020","ddc":["000"],"date_updated":"2026-05-15T22:31:16Z","publication_status":"published","month":"10","author":[{"last_name":"Asadi","first_name":"Ali","full_name":"Asadi, Ali"},{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu","first_name":"Krishnendu","orcid":"0000-0002-4561-241X"},{"full_name":"Goharshady, Amir Kafshdar","first_name":"Amir Kafshdar","orcid":"0000-0003-1702-6584","id":"391365CE-F248-11E8-B48F-1D18A9856A87","last_name":"Goharshady"},{"first_name":"Kiarash","full_name":"Mohammadi, Kiarash","last_name":"Mohammadi"},{"full_name":"Pavlogiannis, Andreas","first_name":"Andreas","orcid":"0000-0002-8943-0722","id":"49704004-F248-11E8-B48F-1D18A9856A87","last_name":"Pavlogiannis"}],"_id":"8728","language":[{"iso":"eng"}],"publication":"Automated Technology for Verification and Analysis","title":"Faster algorithms for quantitative analysis of MCs and MDPs with small treewidth","scopus_import":"1","file":[{"creator":"dernst","file_id":"8729","file_name":"2020_LNCS_ATVA_Asadi_accepted.pdf","access_level":"open_access","content_type":"application/pdf","relation":"main_file","checksum":"ae83f27e5b189d5abc2e7514f1b7e1b5","file_size":726648,"date_updated":"2020-11-06T07:41:03Z","date_created":"2020-11-06T07:41:03Z","success":1}],"status":"public"},{"scopus_import":"1","status":"public","title":"Polynomial invariant generation for non-deterministic recursive programs","_id":"8089","language":[{"iso":"eng"}],"publication":"Proceedings of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation","author":[{"last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu"},{"full_name":"Fu, Hongfei","first_name":"Hongfei","last_name":"Fu","id":"3AAD03D6-F248-11E8-B48F-1D18A9856A87"},{"id":"391365CE-F248-11E8-B48F-1D18A9856A87","last_name":"Goharshady","full_name":"Goharshady, Amir Kafshdar","first_name":"Amir Kafshdar","orcid":"0000-0003-1702-6584"},{"full_name":"Goharshady, Ehsan Kafshdar","first_name":"Ehsan Kafshdar","last_name":"Goharshady"}],"month":"06","publication_status":"published","date_updated":"2026-05-15T22:31:16Z","year":"2020","isi":1,"project":[{"grant_number":"S 11407_N23","name":"Rigorous Systems Engineering","call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425"},{"name":"Efficient Algorithms for Computer Aided Verification","_id":"25892FC0-B435-11E9-9278-68D0E5697425","grant_number":"ICT15-003"}],"abstract":[{"lang":"eng","text":"We consider the classical problem of invariant generation for programs with polynomial assignments and focus on synthesizing invariants that are a conjunction of strict polynomial inequalities. We present a sound and semi-complete method based on positivstellensaetze, i.e. theorems in semi-algebraic geometry that characterize positive polynomials over a semi-algebraic set.\r\n\r\nOn the theoretical side, the worst-case complexity of our approach is subexponential, whereas the worst-case complexity of the previous complete method (Kapur, ACA 2004) is doubly-exponential. Even when restricted to linear invariants, the best previous complexity for complete invariant generation is exponential (Colon et al, CAV 2003). On the practical side, we reduce the invariant generation problem to quadratic programming (QCLP), which is a classical optimization problem with many industrial solvers. We demonstrate the applicability of our approach by providing experimental results on several academic benchmarks. To the best of our knowledge, the only previous invariant generation method that provides completeness guarantees for invariants consisting of polynomial inequalities is (Kapur, ACA 2004), which relies on quantifier elimination and cannot even handle toy programs such as our running example."}],"page":"672-687","oa_version":"Preprint","external_id":{"isi":["000614622300045"],"arxiv":["1902.04373"]},"related_material":{"record":[{"relation":"dissertation_contains","id":"8934","status":"public"}]},"date_created":"2020-07-05T22:00:45Z","publication_identifier":{"isbn":["9781450376136"]},"article_processing_charge":"No","publisher":"Association for Computing Machinery","citation":{"short":"K. Chatterjee, H. Fu, A.K. Goharshady, E.K. Goharshady, in:, Proceedings of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation, Association for Computing Machinery, 2020, pp. 672–687.","ama":"Chatterjee K, Fu H, Goharshady AK, Goharshady EK. Polynomial invariant generation for non-deterministic recursive programs. In: <i>Proceedings of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation</i>. Association for Computing Machinery; 2020:672-687. doi:<a href=\"https://doi.org/10.1145/3385412.3385969\">10.1145/3385412.3385969</a>","apa":"Chatterjee, K., Fu, H., Goharshady, A. K., &#38; Goharshady, E. K. (2020). Polynomial invariant generation for non-deterministic recursive programs. In <i>Proceedings of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation</i> (pp. 672–687). London, United Kingdom: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3385412.3385969\">https://doi.org/10.1145/3385412.3385969</a>","chicago":"Chatterjee, Krishnendu, Hongfei Fu, Amir Kafshdar Goharshady, and Ehsan Kafshdar Goharshady. “Polynomial Invariant Generation for Non-Deterministic Recursive Programs.” In <i>Proceedings of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation</i>, 672–87. Association for Computing Machinery, 2020. <a href=\"https://doi.org/10.1145/3385412.3385969\">https://doi.org/10.1145/3385412.3385969</a>.","ieee":"K. Chatterjee, H. Fu, A. K. Goharshady, and E. K. Goharshady, “Polynomial invariant generation for non-deterministic recursive programs,” in <i>Proceedings of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation</i>, London, United Kingdom, 2020, pp. 672–687.","ista":"Chatterjee K, Fu H, Goharshady AK, Goharshady EK. 2020. Polynomial invariant generation for non-deterministic recursive programs. Proceedings of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation. PLDI: Programming Language Design and Implementation, 672–687.","mla":"Chatterjee, Krishnendu, et al. “Polynomial Invariant Generation for Non-Deterministic Recursive Programs.” <i>Proceedings of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation</i>, Association for Computing Machinery, 2020, pp. 672–87, doi:<a href=\"https://doi.org/10.1145/3385412.3385969\">10.1145/3385412.3385969</a>."},"department":[{"_id":"KrCh"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2020-06-11T00:00:00Z","arxiv":1,"day":"11","quality_controlled":"1","oa":1,"doi":"10.1145/3385412.3385969","conference":{"location":"London, United Kingdom","end_date":"2020-06-20","name":"PLDI: Programming Language Design and Implementation","start_date":"2020-06-15"},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1902.04373"}],"type":"conference"},{"date_created":"2019-09-29T22:00:44Z","related_material":{"record":[{"id":"8934","relation":"dissertation_contains","status":"public"}]},"external_id":{"isi":["000501641400050"],"arxiv":["1712.09692"]},"oa_version":"Preprint","abstract":[{"lang":"eng","text":"We consider the classic problem of Network Reliability. A network is given together with a source vertex, one or more target vertices, and probabilities assigned to each of the edges. Each edge of the network is operable with its associated probability and the problem is to determine the probability of having at least one source-to-target path that is entirely composed of operable edges. This problem is known to be NP-hard.\r\n\r\nWe provide a novel scalable algorithm to solve the Network Reliability problem when the treewidth of the underlying network is small. We also show our algorithm’s applicability for real-world transit networks that have small treewidth, including the metro networks of major cities, such as London and Tokyo. Our algorithm leverages tree decompositions to shrink the original graph into much smaller graphs, for which reliability can be efficiently and exactly computed using a brute force method. To the best of our knowledge, this is the first exact algorithm for Network Reliability that can scale to handle real-world instances of the problem."}],"isi":1,"volume":193,"project":[{"name":"Quantitative Game-theoretic Analysis of Blockchain Applications and Smart Contracts","_id":"266EEEC0-B435-11E9-9278-68D0E5697425"}],"year":"2020","date_updated":"2026-05-15T22:31:17Z","publication_status":"published","author":[{"id":"391365CE-F248-11E8-B48F-1D18A9856A87","last_name":"Goharshady","full_name":"Goharshady, Amir Kafshdar","first_name":"Amir Kafshdar","orcid":"0000-0003-1702-6584"},{"last_name":"Mohammadi","first_name":"Fatemeh","full_name":"Mohammadi, Fatemeh"}],"month":"01","publication":"Reliability Engineering and System Safety","language":[{"iso":"eng"}],"_id":"6918","title":"An efficient algorithm for computing network reliability in small treewidth","scopus_import":"1","status":"public","article_type":"original","article_number":"106665","acknowledgement":"We are grateful to the anonymous reviewers for their comments, which significantly improved the present work. The research was partially supported by the EPSRC Early Career Fellowship EP/R023379/1, grant no. SC7-1718-01 of the London Mathematical Society, an IBM PhD Fellowship, and a DOC Fellowship of the Austrian Academy of Sciences (ÖAW).","type":"journal_article","main_file_link":[{"url":"https://arxiv.org/abs/1712.09692","open_access":"1"}],"doi":"10.1016/j.ress.2019.106665","oa":1,"quality_controlled":"1","arxiv":1,"day":"01","intvolume":"       193","date_published":"2020-01-01T00:00:00Z","citation":{"ista":"Goharshady AK, Mohammadi F. 2020. An efficient algorithm for computing network reliability in small treewidth. Reliability Engineering and System Safety. 193, 106665.","apa":"Goharshady, A. K., &#38; Mohammadi, F. (2020). An efficient algorithm for computing network reliability in small treewidth. <i>Reliability Engineering and System Safety</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ress.2019.106665\">https://doi.org/10.1016/j.ress.2019.106665</a>","chicago":"Goharshady, Amir Kafshdar, and Fatemeh Mohammadi. “An Efficient Algorithm for Computing Network Reliability in Small Treewidth.” <i>Reliability Engineering and System Safety</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.ress.2019.106665\">https://doi.org/10.1016/j.ress.2019.106665</a>.","ieee":"A. K. Goharshady and F. Mohammadi, “An efficient algorithm for computing network reliability in small treewidth,” <i>Reliability Engineering and System Safety</i>, vol. 193. Elsevier, 2020.","mla":"Goharshady, Amir Kafshdar, and Fatemeh Mohammadi. “An Efficient Algorithm for Computing Network Reliability in Small Treewidth.” <i>Reliability Engineering and System Safety</i>, vol. 193, 106665, Elsevier, 2020, doi:<a href=\"https://doi.org/10.1016/j.ress.2019.106665\">10.1016/j.ress.2019.106665</a>.","short":"A.K. Goharshady, F. Mohammadi, Reliability Engineering and System Safety 193 (2020).","ama":"Goharshady AK, Mohammadi F. An efficient algorithm for computing network reliability in small treewidth. <i>Reliability Engineering and System Safety</i>. 2020;193. doi:<a href=\"https://doi.org/10.1016/j.ress.2019.106665\">10.1016/j.ress.2019.106665</a>"},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","department":[{"_id":"KrCh"}],"publisher":"Elsevier","article_processing_charge":"No","publication_identifier":{"issn":["0951-8320"]}},{"ec_funded":1,"abstract":[{"text":"Flowering plants display the highest diversity among plant species and have notably shaped terrestrial landscapes. Nonetheless, the evolutionary origin of their unprecedented morphological complexity remains largely an enigma. Here, we show that the coevolution of cis-regulatory and coding regions of PIN-FORMED (PIN) auxin transporters confined their expression to certain cell types and directed their subcellular localization to particular cell sides, which together enabled dynamic auxin gradients across tissues critical to the complex architecture of flowering plants. Extensive intraspecies and interspecies genetic complementation experiments with PINs from green alga up to flowering plant lineages showed that PIN genes underwent three subsequent, critical evolutionary innovations and thus acquired a triple function to regulate the development of three essential components of the flowering plant Arabidopsis: shoot/root, inflorescence, and floral organ. Our work highlights the critical role of functional innovations within the PIN gene family as essential prerequisites for the origin of flowering plants.","lang":"eng"}],"year":"2020","volume":6,"isi":1,"project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985"},{"_id":"26538374-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Molecular mechanisms of endocytic cargo recognition in plants","grant_number":"I03630"},{"grant_number":"25351","_id":"26B4D67E-B435-11E9-9278-68D0E5697425","name":"A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated Rapid Growth Inhibition in Arabidopsis Root"}],"external_id":{"isi":["000599903600014"],"pmid":["33310852"]},"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"10083"}]},"date_created":"2021-01-03T23:01:23Z","oa_version":"Published Version","_id":"8986","publication":"Science Advances","language":[{"iso":"eng"}],"article_type":"original","scopus_import":"1","file":[{"file_id":"8994","creator":"dernst","file_name":"2020_ScienceAdvances_Zhang.pdf","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_size":10578145,"checksum":"5ac2500b191c08ef6dab5327f40ff663","date_updated":"2021-01-07T12:44:33Z","date_created":"2021-01-07T12:44:33Z","success":1}],"status":"public","title":"Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants","ddc":["580"],"publication_status":"published","date_updated":"2026-05-15T22:31:18Z","author":[{"last_name":"Zhang","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87","full_name":"Zhang, Yuzhou","orcid":"0000-0003-2627-6956","first_name":"Yuzhou"},{"id":"3922B506-F248-11E8-B48F-1D18A9856A87","last_name":"Rodriguez Solovey","full_name":"Rodriguez Solovey, Lesia","first_name":"Lesia","orcid":"0000-0002-7244-7237"},{"last_name":"Li","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","full_name":"Li, Lanxin","orcid":"0000-0002-5607-272X","first_name":"Lanxin"},{"last_name":"Zhang","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A","full_name":"Zhang, Xixi","orcid":"0000-0001-7048-4627","first_name":"Xixi"},{"first_name":"Jiří","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"}],"month":"12","pmid":1,"type":"journal_article","file_date_updated":"2021-01-07T12:44:33Z","oa":1,"doi":"10.1126/sciadv.abc8895","acknowledgement":"We thank C.Löhne (Botanic Gardens, University of Bonn) for providing us with A. trichopoda. We would like to thank T.Han, A.Mally (IST, Austria), and C.Hartinger (University of Oxford) for constructive comment and careful reading. Funding: The research leading to these results has received funding from the European Union’s Horizon 2020 Research and Innovation Programme (ERC grant agreement number 742985), Austrian Science Fund (FWF, grant number I 3630-B25), DOC Fellowship of the Austrian Academy of Sciences, and IST Fellow program. ","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"article_number":"eabc8895","corr_author":"1","publisher":"AAAS","issue":"50","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"JiFr"}],"citation":{"mla":"Zhang, Yuzhou, et al. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary Transitions during Rise of Flowering Plants.” <i>Science Advances</i>, vol. 6, no. 50, eabc8895, AAAS, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.abc8895\">10.1126/sciadv.abc8895</a>.","ista":"Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. 2020. Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. Science Advances. 6(50), eabc8895.","chicago":"Zhang, Yuzhou, Lesia Rodriguez Solovey, Lanxin Li, Xixi Zhang, and Jiří Friml. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary Transitions during Rise of Flowering Plants.” <i>Science Advances</i>. AAAS, 2020. <a href=\"https://doi.org/10.1126/sciadv.abc8895\">https://doi.org/10.1126/sciadv.abc8895</a>.","ieee":"Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, and J. Friml, “Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants,” <i>Science Advances</i>, vol. 6, no. 50. AAAS, 2020.","apa":"Zhang, Y., Rodriguez Solovey, L., Li, L., Zhang, X., &#38; Friml, J. (2020). Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.abc8895\">https://doi.org/10.1126/sciadv.abc8895</a>","ama":"Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. <i>Science Advances</i>. 2020;6(50). doi:<a href=\"https://doi.org/10.1126/sciadv.abc8895\">10.1126/sciadv.abc8895</a>","short":"Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, J. Friml, Science Advances 6 (2020)."},"publication_identifier":{"eissn":["2375-2548"]},"article_processing_charge":"No","day":"11","quality_controlled":"1","date_published":"2020-12-11T00:00:00Z","intvolume":"         6"},{"intvolume":"        21","date_published":"2020-08-10T00:00:00Z","quality_controlled":"1","day":"10","article_processing_charge":"No","publication_identifier":{"eissn":["1422-0067"],"issn":["1661-6596"]},"issue":"16","publisher":"MDPI","citation":{"ieee":"H. Chen <i>et al.</i>, “AcoMYB4, an Ananas comosus L. MYB transcription factor, functions in osmotic stress through negative regulation of ABA signaling,” <i>International Journal of Molecular Sciences</i>, vol. 21, no. 16. MDPI, 2020.","apa":"Chen, H., Lai, L., Li, L., Liu, L., Jakada, B. H., Huang, Y., … Qin, Y. (2020). AcoMYB4, an Ananas comosus L. MYB transcription factor, functions in osmotic stress through negative regulation of ABA signaling. <i>International Journal of Molecular Sciences</i>. MDPI. <a href=\"https://doi.org/10.3390/ijms21165727\">https://doi.org/10.3390/ijms21165727</a>","chicago":"Chen, Huihuang, Linyi Lai, Lanxin Li, Liping Liu, Bello Hassan Jakada, Youmei Huang, Qing He, Mengnan Chai, Xiaoping Niu, and Yuan Qin. “AcoMYB4, an Ananas Comosus L. MYB Transcription Factor, Functions in Osmotic Stress through Negative Regulation of ABA Signaling.” <i>International Journal of Molecular Sciences</i>. MDPI, 2020. <a href=\"https://doi.org/10.3390/ijms21165727\">https://doi.org/10.3390/ijms21165727</a>.","ista":"Chen H, Lai L, Li L, Liu L, Jakada BH, Huang Y, He Q, Chai M, Niu X, Qin Y. 2020. AcoMYB4, an Ananas comosus L. MYB transcription factor, functions in osmotic stress through negative regulation of ABA signaling. International Journal of Molecular Sciences. 21(16), 5272.","mla":"Chen, Huihuang, et al. “AcoMYB4, an Ananas Comosus L. MYB Transcription Factor, Functions in Osmotic Stress through Negative Regulation of ABA Signaling.” <i>International Journal of Molecular Sciences</i>, vol. 21, no. 16, 5272, MDPI, 2020, doi:<a href=\"https://doi.org/10.3390/ijms21165727\">10.3390/ijms21165727</a>.","short":"H. Chen, L. Lai, L. Li, L. Liu, B.H. Jakada, Y. Huang, Q. He, M. Chai, X. Niu, Y. Qin, International Journal of Molecular Sciences 21 (2020).","ama":"Chen H, Lai L, Li L, et al. AcoMYB4, an Ananas comosus L. MYB transcription factor, functions in osmotic stress through negative regulation of ABA signaling. <i>International Journal of Molecular Sciences</i>. 2020;21(16). doi:<a href=\"https://doi.org/10.3390/ijms21165727\">10.3390/ijms21165727</a>"},"department":[{"_id":"JiFr"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_number":"5272","acknowledgement":"We would like to thank the reviewers for their helpful comments on the original manuscript. ","has_accepted_license":"1","doi":"10.3390/ijms21165727","oa":1,"pmid":1,"type":"journal_article","file_date_updated":"2020-08-25T09:53:50Z","author":[{"full_name":"Chen, Huihuang","first_name":"Huihuang","last_name":"Chen"},{"last_name":"Lai","full_name":"Lai, Linyi","first_name":"Linyi"},{"last_name":"Li","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5607-272X","first_name":"Lanxin","full_name":"Li, Lanxin"},{"full_name":"Liu, Liping","first_name":"Liping","last_name":"Liu"},{"first_name":"Bello Hassan","full_name":"Jakada, Bello Hassan","last_name":"Jakada"},{"first_name":"Youmei","full_name":"Huang, Youmei","last_name":"Huang"},{"last_name":"He","full_name":"He, Qing","first_name":"Qing"},{"first_name":"Mengnan","full_name":"Chai, Mengnan","last_name":"Chai"},{"last_name":"Niu","full_name":"Niu, Xiaoping","first_name":"Xiaoping"},{"last_name":"Qin","first_name":"Yuan","full_name":"Qin, Yuan"}],"month":"08","publication_status":"published","date_updated":"2026-05-15T22:31:18Z","ddc":["570"],"status":"public","scopus_import":"1","file":[{"creator":"cziletti","file_id":"8292","file_name":"2020_IntMolecSciences_Chen.pdf","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_size":5718755,"checksum":"03b039244e6ae80580385fd9f577e2b2","date_updated":"2020-08-25T09:53:50Z","date_created":"2020-08-25T09:53:50Z","success":1}],"title":"AcoMYB4, an Ananas comosus L. MYB transcription factor, functions in osmotic stress through negative regulation of ABA signaling","article_type":"original","language":[{"iso":"eng"}],"publication":"International Journal of Molecular Sciences","_id":"8283","oa_version":"Published Version","external_id":{"pmid":["32785037"],"isi":["000565090300001"]},"date_created":"2020-08-24T06:24:03Z","related_material":{"record":[{"status":"public","id":"10083","relation":"dissertation_contains"}]},"year":"2020","isi":1,"volume":21,"abstract":[{"lang":"eng","text":"Drought and salt stress are the main environmental cues affecting the survival, development, distribution, and yield of crops worldwide. MYB transcription factors play a crucial role in plants’ biological processes, but the function of pineapple MYB genes is still obscure. In this study, one of the pineapple MYB transcription factors, AcoMYB4, was isolated and characterized. The results showed that AcoMYB4 is localized in the cell nucleus, and its expression is induced by low temperature, drought, salt stress, and hormonal stimulation, especially by abscisic acid (ABA). Overexpression of AcoMYB4 in rice and Arabidopsis enhanced plant sensitivity to osmotic stress; it led to an increase in the number stomata on leaf surfaces and lower germination rate under salt and drought stress. Furthermore, in AcoMYB4 OE lines, the membrane oxidation index, free proline, and soluble sugar contents were decreased. In contrast, electrolyte leakage and malondialdehyde (MDA) content increased significantly due to membrane injury, indicating higher sensitivity to drought and salinity stresses. Besides the above, both the expression level and activities of several antioxidant enzymes were decreased, indicating lower antioxidant activity in AcoMYB4 transgenic plants. Moreover, under osmotic stress, overexpression of AcoMYB4 inhibited ABA biosynthesis through a decrease in the transcription of genes responsible for ABA synthesis (ABA1 and ABA2) and ABA signal transduction factor ABI5. These results suggest that AcoMYB4 negatively regulates osmotic stress by attenuating cellular ABA biosynthesis and signal transduction pathways. "}]},{"publisher":"Springer Nature","citation":{"mla":"Arnold, Georg M., et al. “Converting Microwave and Telecom Photons with a Silicon Photonic Nanomechanical Interface.” <i>Nature Communications</i>, vol. 11, 4460, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-18269-z\">10.1038/s41467-020-18269-z</a>.","ista":"Arnold GM, Wulf M, Barzanjeh S, Redchenko E, Rueda Sanchez AR, Hease WJ, Hassani F, Fink JM. 2020. Converting microwave and telecom photons with a silicon photonic nanomechanical interface. Nature Communications. 11, 4460.","chicago":"Arnold, Georg M, Matthias Wulf, Shabir Barzanjeh, Elena Redchenko, Alfredo R Rueda Sanchez, William J Hease, Farid Hassani, and Johannes M Fink. “Converting Microwave and Telecom Photons with a Silicon Photonic Nanomechanical Interface.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-18269-z\">https://doi.org/10.1038/s41467-020-18269-z</a>.","ieee":"G. M. Arnold <i>et al.</i>, “Converting microwave and telecom photons with a silicon photonic nanomechanical interface,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","apa":"Arnold, G. M., Wulf, M., Barzanjeh, S., Redchenko, E., Rueda Sanchez, A. R., Hease, W. J., … Fink, J. M. (2020). Converting microwave and telecom photons with a silicon photonic nanomechanical interface. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-18269-z\">https://doi.org/10.1038/s41467-020-18269-z</a>","ama":"Arnold GM, Wulf M, Barzanjeh S, et al. Converting microwave and telecom photons with a silicon photonic nanomechanical interface. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-18269-z\">10.1038/s41467-020-18269-z</a>","short":"G.M. Arnold, M. Wulf, S. Barzanjeh, E. Redchenko, A.R. Rueda Sanchez, W.J. Hease, F. Hassani, J.M. Fink, Nature Communications 11 (2020)."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JoFi"}],"publication_identifier":{"issn":["2041-1723"]},"article_processing_charge":"No","day":"08","quality_controlled":"1","date_published":"2020-09-08T00:00:00Z","intvolume":"        11","type":"journal_article","pmid":1,"file_date_updated":"2020-09-18T13:02:37Z","oa":1,"doi":"10.1038/s41467-020-18269-z","acknowledgement":"We thank Yuan Chen for performing supplementary FEM simulations and Andrew Higginbotham, Ralf Riedinger, Sungkun Hong, and Lorenzo Magrini for valuable discussions. This work was supported by IST Austria, the IST nanofabrication facility (NFF), the European Union’s Horizon 2020 research and innovation program under grant agreement no. 732894 (FET Proactive HOT) and the European Research Council under grant agreement no. 758053 (ERC StG QUNNECT). G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 754411. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (F71), a NOMIS foundation research grant, and the EU’s Horizon 2020 research and innovation program under grant agreement no. 862644 (FET Open QUARTET).","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_number":"4460","keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"corr_author":"1","acknowledged_ssus":[{"_id":"NanoFab"}],"_id":"8529","publication":"Nature Communications","language":[{"iso":"eng"}],"article_type":"original","file":[{"checksum":"88f92544889eb18bb38e25629a422a86","file_size":1002818,"date_created":"2020-09-18T13:02:37Z","success":1,"date_updated":"2020-09-18T13:02:37Z","creator":"dernst","file_id":"8530","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_name":"2020_NatureComm_Arnold.pdf"}],"status":"public","scopus_import":"1","title":"Converting microwave and telecom photons with a silicon photonic nanomechanical interface","ddc":["530"],"publication_status":"published","date_updated":"2026-05-15T22:31:21Z","month":"09","author":[{"first_name":"Georg M","orcid":"0000-0003-1397-7876","full_name":"Arnold, Georg M","id":"3770C838-F248-11E8-B48F-1D18A9856A87","last_name":"Arnold"},{"full_name":"Wulf, Matthias","orcid":"0000-0001-6613-1378","first_name":"Matthias","last_name":"Wulf","id":"45598606-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Barzanjeh","id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0415-1423","first_name":"Shabir","full_name":"Barzanjeh, Shabir"},{"id":"2C21D6E8-F248-11E8-B48F-1D18A9856A87","last_name":"Redchenko","first_name":"Elena","full_name":"Redchenko, Elena"},{"first_name":"Alfredo R","orcid":"0000-0001-6249-5860","full_name":"Rueda Sanchez, Alfredo R","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","last_name":"Rueda Sanchez"},{"last_name":"Hease","id":"29705398-F248-11E8-B48F-1D18A9856A87","full_name":"Hease, William J","orcid":"0000-0001-9868-2166","first_name":"William J"},{"last_name":"Hassani","id":"2AED110C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6937-5773","first_name":"Farid","full_name":"Hassani, Farid"},{"id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","last_name":"Fink","full_name":"Fink, Johannes M","first_name":"Johannes M","orcid":"0000-0001-8112-028X"}],"abstract":[{"text":"Practical quantum networks require low-loss and noise-resilient optical interconnects as well as non-Gaussian resources for entanglement distillation and distributed quantum computation. The latter could be provided by superconducting circuits but existing solutions to interface the microwave and optical domains lack either scalability or efficiency, and in most cases the conversion noise is not known. In this work we utilize the unique opportunities of silicon photonics, cavity optomechanics and superconducting circuits to demonstrate a fully integrated, coherent transducer interfacing the microwave X and the telecom S bands with a total (internal) bidirectional transduction efficiency of 1.2% (135%) at millikelvin temperatures. The coupling relies solely on the radiation pressure interaction mediated by the femtometer-scale motion of two silicon nanobeams reaching a <jats:italic>V</jats:italic><jats:sub><jats:italic>π</jats:italic></jats:sub> as low as 16 μV for sub-nanowatt pump powers. Without the associated optomechanical gain, we achieve a total (internal) pure conversion efficiency of up to 0.019% (1.6%), relevant for future noise-free operation on this qubit-compatible platform.","lang":"eng"}],"ec_funded":1,"year":"2020","isi":1,"volume":11,"project":[{"grant_number":"732894","call_identifier":"H2020","name":"Hybrid Optomechanical Technologies","_id":"257EB838-B435-11E9-9278-68D0E5697425"},{"grant_number":"758053","call_identifier":"H2020","name":"A Fiber Optic Transceiver for Superconducting Qubits","_id":"26336814-B435-11E9-9278-68D0E5697425"},{"_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411"},{"call_identifier":"H2020","name":"Quantum readout techniques and technologies","_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","grant_number":"862644"},{"name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies","_id":"2671EB66-B435-11E9-9278-68D0E5697425"}],"external_id":{"isi":["000577280200001"],"pmid":["32901014"]},"date_created":"2020-09-18T10:56:20Z","related_material":{"record":[{"id":"13056","relation":"research_data","status":"public"},{"id":"18871","relation":"dissertation_contains","status":"public"}],"link":[{"url":"https://doi.org/10.1038/s41467-020-18912-9","relation":"erratum"},{"url":"https://ist.ac.at/en/news/how-to-transport-microwave-quantum-information-via-optical-fiber/","relation":"press_release","description":"News on IST Homepage"}]},"oa_version":"Published Version"},{"oa":1,"doi":"10.1103/prxquantum.1.020315","type":"journal_article","file_date_updated":"2021-02-12T11:16:16Z","acknowledged_ssus":[{"_id":"M-Shop"}],"corr_author":"1","acknowledgement":"The authors acknowledge the support of T. Menner, A. Arslani, and T. Asenov from the Miba machine shop for machining the microwave cavity, and thank S. Barzanjeh, F. Sedlmeir, and C. Marquardt for fruitful discussions. This work is supported by IST Austria and the European Research Council under Grant No. 758053 (ERC StG QUNNECT). W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant No. 754411.\r\nG.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (F71) and the European Union’s Horizon 2020 research and innovation program under Grant No. 899354 (FET Open SuperQuLAN). H.G.L.S. acknowledges support from the Aotearoa/New Zealand’s MBIE Endeavour Smart Ideas Grant No UOOX1805.","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_number":"020315","publication_identifier":{"issn":["2691-3399"]},"article_processing_charge":"No","publisher":"American Physical Society","issue":"2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JoFi"}],"citation":{"mla":"Hease, William J., et al. “Bidirectional Electro-Optic Wavelength Conversion in the Quantum Ground State.” <i>PRX Quantum</i>, vol. 1, no. 2, 020315, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/prxquantum.1.020315\">10.1103/prxquantum.1.020315</a>.","ista":"Hease WJ, Rueda Sanchez AR, Sahu R, Wulf M, Arnold GM, Schwefel HGL, Fink JM. 2020. Bidirectional electro-optic wavelength conversion in the quantum ground state. PRX Quantum. 1(2), 020315.","chicago":"Hease, William J, Alfredo R Rueda Sanchez, Rishabh Sahu, Matthias Wulf, Georg M Arnold, Harald G.L. Schwefel, and Johannes M Fink. “Bidirectional Electro-Optic Wavelength Conversion in the Quantum Ground State.” <i>PRX Quantum</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/prxquantum.1.020315\">https://doi.org/10.1103/prxquantum.1.020315</a>.","ieee":"W. J. Hease <i>et al.</i>, “Bidirectional electro-optic wavelength conversion in the quantum ground state,” <i>PRX Quantum</i>, vol. 1, no. 2. American Physical Society, 2020.","apa":"Hease, W. J., Rueda Sanchez, A. R., Sahu, R., Wulf, M., Arnold, G. M., Schwefel, H. G. L., &#38; Fink, J. M. (2020). Bidirectional electro-optic wavelength conversion in the quantum ground state. <i>PRX Quantum</i>. American Physical Society. <a href=\"https://doi.org/10.1103/prxquantum.1.020315\">https://doi.org/10.1103/prxquantum.1.020315</a>","ama":"Hease WJ, Rueda Sanchez AR, Sahu R, et al. Bidirectional electro-optic wavelength conversion in the quantum ground state. <i>PRX Quantum</i>. 2020;1(2). doi:<a href=\"https://doi.org/10.1103/prxquantum.1.020315\">10.1103/prxquantum.1.020315</a>","short":"W.J. Hease, A.R. Rueda Sanchez, R. Sahu, M. Wulf, G.M. Arnold, H.G.L. Schwefel, J.M. Fink, PRX Quantum 1 (2020)."},"date_published":"2020-11-23T00:00:00Z","intvolume":"         1","day":"23","quality_controlled":"1","year":"2020","volume":1,"isi":1,"project":[{"name":"A Fiber Optic Transceiver for Superconducting Qubits","call_identifier":"H2020","_id":"26336814-B435-11E9-9278-68D0E5697425","grant_number":"758053"},{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"},{"grant_number":"899354","name":"Quantum Local Area Networks with Superconducting Qubits","call_identifier":"H2020","_id":"9B868D20-BA93-11EA-9121-9846C619BF3A"},{"name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies","_id":"2671EB66-B435-11E9-9278-68D0E5697425"},{"grant_number":"F07105","name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits","_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f"}],"ec_funded":1,"abstract":[{"lang":"eng","text":"Microwave photonics lends the advantages of fiber optics to electronic sensing and communication systems. In contrast to nonlinear optics, electro-optic devices so far require classical modulation fields whose variance is dominated by electronic or thermal noise rather than quantum fluctuations. Here we demonstrate bidirectional single-sideband conversion of X band microwave to C band telecom light with a microwave mode occupancy as low as 0.025 ± 0.005 and an added output noise of less than or equal to 0.074 photons. This is facilitated by radiative cooling and a triply resonant ultra-low-loss transducer operating at millikelvin temperatures. The high bandwidth of 10.7 MHz and total (internal) photon conversion\r\nefficiency of 0.03% (0.67%) combined with the extremely slow heating rate of 1.1 added output noise photons per second for the highest available pump power of 1.48 mW puts near-unity efficiency pulsed quantum transduction within reach. Together with the non-Gaussian resources of superconducting qubits this might provide the practical foundation to extend the range and scope of current quantum networks in analogy to electrical repeaters in classical fiber optic communication."}],"oa_version":"Published Version","external_id":{"isi":["000674680100001"]},"date_created":"2021-02-12T10:41:28Z","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/how-to-transport-microwave-quantum-information-via-optical-fiber/","description":"News on IST Homepage"}],"record":[{"status":"public","id":"13071","relation":"research_data"},{"relation":"dissertation_contains","id":"13175","status":"public"},{"status":"public","relation":"dissertation_contains","id":"12900"},{"id":"18871","relation":"dissertation_contains","status":"public"}]},"article_type":"original","status":"public","file":[{"file_name":"2020_PRXQuantum_Hease.pdf","content_type":"application/pdf","access_level":"open_access","relation":"main_file","creator":"dernst","file_id":"9115","date_updated":"2021-02-12T11:16:16Z","success":1,"date_created":"2021-02-12T11:16:16Z","checksum":"b70b12ded6d7660d4c9037eb09bfed0c","file_size":2146924}],"scopus_import":"1","title":"Bidirectional electro-optic wavelength conversion in the quantum ground state","_id":"9114","language":[{"iso":"eng"}],"publication":"PRX Quantum","month":"11","author":[{"last_name":"Hease","id":"29705398-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9868-2166","first_name":"William J","full_name":"Hease, William J"},{"last_name":"Rueda Sanchez","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","full_name":"Rueda Sanchez, Alfredo R","orcid":"0000-0001-6249-5860","first_name":"Alfredo R"},{"last_name":"Sahu","id":"47D26E34-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6264-2162","first_name":"Rishabh","full_name":"Sahu, Rishabh"},{"id":"45598606-F248-11E8-B48F-1D18A9856A87","last_name":"Wulf","full_name":"Wulf, Matthias","first_name":"Matthias","orcid":"0000-0001-6613-1378"},{"full_name":"Arnold, Georg M","first_name":"Georg M","orcid":"0000-0003-1397-7876","id":"3770C838-F248-11E8-B48F-1D18A9856A87","last_name":"Arnold"},{"full_name":"Schwefel, Harald G.L.","first_name":"Harald G.L.","last_name":"Schwefel"},{"first_name":"Johannes M","orcid":"0000-0001-8112-028X","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","last_name":"Fink"}],"ddc":["530"],"publication_status":"published","date_updated":"2026-05-15T22:31:21Z"},{"oa_version":"Published Version","date_created":"2022-07-06T09:07:06Z","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1051/0004-6361/201834565e"}]},"external_id":{"arxiv":["1902.05960"]},"volume":648,"year":"2019","abstract":[{"text":"Deep optical spectroscopic surveys of galaxies provide a unique opportunity to investigate rest-frame ultra-violet (UV) emission line properties of galaxies at z ∼ 2 − 4.5. Here we combine VLT/MUSE Guaranteed Time Observations of the Hubble Deep Field South, Ultra Deep Field, COSMOS, and several quasar fields with other publicly available data from VLT/VIMOS and VLT/FORS2 to construct a catalogue of He II λ1640 emitters at z ≳ 2. The deepest areas of our MUSE pointings reach a 3σ line flux limit of 3.1 × 10−19 erg s−1 cm−2. After discarding broad-line active galactic nuclei, we find 13 He II λ1640 detections from MUSE with a median MUV = −20.1 and 21 tentative He II λ1640 detections from other public surveys. Excluding Lyα, all except two galaxies in our sample show at least one other rest-UV emission line, with C III] λ1907, λ1909 being the most prominent. We use multi-wavelength data available in the Hubble legacy fields to derive basic galaxy properties of our sample through spectral energy distribution fitting techniques. Taking advantage of the high-quality spectra obtained by MUSE (∼10 − 30 h of exposure time per pointing), we use photo-ionisation models to study the rest-UV emission line diagnostics of the He II λ1640 emitters. Line ratios of our sample can be reproduced by moderately sub-solar photo-ionisation models, however, we find that including effects of binary stars lead to degeneracies in most free parameters. Even after considering extra ionising photons produced by extreme sub-solar metallicity binary stellar models, photo-ionisation models are unable to reproduce rest-frame He II λ1640 equivalent widths (∼0.2 − 10 Å), thus additional mechanisms are necessary in models to match the observed He II λ1640 properties.","lang":"eng"}],"month":"04","author":[{"full_name":"Nanayakkara, Themiya","first_name":"Themiya","last_name":"Nanayakkara"},{"last_name":"Brinchmann","first_name":"Jarle","full_name":"Brinchmann, Jarle"},{"last_name":"Boogaard","first_name":"Leindert","full_name":"Boogaard, Leindert"},{"last_name":"Bouwens","first_name":"Rychard","full_name":"Bouwens, Rychard"},{"last_name":"Cantalupo","first_name":"Sebastiano","full_name":"Cantalupo, Sebastiano"},{"full_name":"Feltre, Anna","first_name":"Anna","last_name":"Feltre"},{"last_name":"Kollatschny","first_name":"Wolfram","full_name":"Kollatschny, Wolfram"},{"last_name":"Marino","full_name":"Marino, Raffaella Anna","first_name":"Raffaella Anna"},{"full_name":"Maseda, Michael","first_name":"Michael","last_name":"Maseda"},{"last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720","full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","first_name":"Jorryt J"},{"last_name":"Paalvast","full_name":"Paalvast, Mieke","first_name":"Mieke"},{"full_name":"Richard, Johan","first_name":"Johan","last_name":"Richard"},{"last_name":"Verhamme","full_name":"Verhamme, Anne","first_name":"Anne"}],"date_updated":"2022-07-19T09:36:08Z","publication_status":"published","title":"Exploring He II λ1640 emission line properties at z ∼2−4","scopus_import":"1","status":"public","article_type":"original","extern":"1","language":[{"iso":"eng"}],"publication":"Astronomy & Astrophysics","_id":"11499","keyword":["Space and Planetary Science","Astronomy and Astrophysics","galaxies: ISM / galaxies: star formation / galaxies: evolution / galaxies: high-redshift"],"article_number":"A89","acknowledgement":"The authors wish to thank the referee for constructive comments that improved the paper substantially. We thank the BPASS team for making the stellar population models available. We thank Elizabeth Stanway, Claus Leitherer, Daniel Schaerer, Jorick Vink, and Nell Byler for insightful discussions. We thank the Lorentz Centre and the scientific organizers of the Characterizing galaxies with spectroscopy with a view for JWST workshop held at the Lorentz Centre in 2017 October, which promoted useful discussions in the wider community. TN, JB, and RB acknowledges the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) top grant TOP1.16.057. AF acknowledges support from the ERC via an Advanced Grant under grant agreement no. 339659-MUSICOS. JB acknowledges support by Fundação para a Ciência e a Tecnologia (FCT) through national funds (UID/FIS/04434/2013) and Investigador FCT contract IF/01654/2014/CP1215/CT0003, and by FEDER through COMPETE2020 (POCI-01-0145-FEDER-007672). JR acknowledges support from the ERC Starting grant 336736 (CALENDS). This research made use of astropy (http://www.astropy.org) a community-developed core Python package for Astronomy (Astropy Collaboration 2013, 2018) and pandas (McKinney 2010). Figures were generated using matplotlib (Hunter 2007) and seaborn (https://seaborn.pydata.org). Facilities: VLT (MUSE).","doi":"10.1051/0004-6361/201834565","oa":1,"type":"journal_article","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1902.05960"}],"intvolume":"       648","date_published":"2019-04-16T00:00:00Z","quality_controlled":"1","arxiv":1,"day":"16","article_processing_charge":"No","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Nanayakkara, Themiya, Jarle Brinchmann, Leindert Boogaard, Rychard Bouwens, Sebastiano Cantalupo, Anna Feltre, Wolfram Kollatschny, et al. “Exploring He II Λ1640 Emission Line Properties at z ∼2−4.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2019. <a href=\"https://doi.org/10.1051/0004-6361/201834565\">https://doi.org/10.1051/0004-6361/201834565</a>.","apa":"Nanayakkara, T., Brinchmann, J., Boogaard, L., Bouwens, R., Cantalupo, S., Feltre, A., … Verhamme, A. (2019). Exploring He II λ1640 emission line properties at z ∼2−4. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/201834565\">https://doi.org/10.1051/0004-6361/201834565</a>","ieee":"T. Nanayakkara <i>et al.</i>, “Exploring He II λ1640 emission line properties at z ∼2−4,” <i>Astronomy &#38; Astrophysics</i>, vol. 648. EDP Sciences, 2019.","ista":"Nanayakkara T, Brinchmann J, Boogaard L, Bouwens R, Cantalupo S, Feltre A, Kollatschny W, Marino RA, Maseda M, Matthee JJ, Paalvast M, Richard J, Verhamme A. 2019. Exploring He II λ1640 emission line properties at z ∼2−4. Astronomy &#38; Astrophysics. 648, A89.","mla":"Nanayakkara, Themiya, et al. “Exploring He II Λ1640 Emission Line Properties at z ∼2−4.” <i>Astronomy &#38; Astrophysics</i>, vol. 648, A89, EDP Sciences, 2019, doi:<a href=\"https://doi.org/10.1051/0004-6361/201834565\">10.1051/0004-6361/201834565</a>.","short":"T. Nanayakkara, J. Brinchmann, L. Boogaard, R. Bouwens, S. Cantalupo, A. Feltre, W. Kollatschny, R.A. Marino, M. Maseda, J.J. Matthee, M. Paalvast, J. Richard, A. Verhamme, Astronomy &#38; Astrophysics 648 (2019).","ama":"Nanayakkara T, Brinchmann J, Boogaard L, et al. Exploring He II λ1640 emission line properties at z ∼2−4. <i>Astronomy &#38; Astrophysics</i>. 2019;648. doi:<a href=\"https://doi.org/10.1051/0004-6361/201834565\">10.1051/0004-6361/201834565</a>"},"publisher":"EDP Sciences"},{"article_processing_charge":"No","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"publisher":"EDP Sciences","citation":{"short":"G. de La Vieuville, D. Bina, R. Pello, G. Mahler, J. Richard, A.B. Drake, E.C. Herenz, F.E. Bauer, B. Clément, D. Lagattuta, N. Laporte, J. Martinez, V. Patrício, L. Wisotzki, J. Zabl, R.J. Bouwens, T. Contini, T. Garel, B. Guiderdoni, R.A. Marino, M.V. Maseda, J.J. Matthee, J. Schaye, G. Soucail, Astronomy &#38; Astrophysics 628 (2019).","ama":"de La Vieuville G, Bina D, Pello R, et al. Faint end of the z ∼ 3–7 luminosity function of Lyman-alpha emitters behind lensing clusters observed with MUSE. <i>Astronomy &#38; Astrophysics</i>. 2019;628. doi:<a href=\"https://doi.org/10.1051/0004-6361/201834471\">10.1051/0004-6361/201834471</a>","ista":"de La Vieuville G, Bina D, Pello R, Mahler G, Richard J, Drake AB, Herenz EC, Bauer FE, Clément B, Lagattuta D, Laporte N, Martinez J, Patrício V, Wisotzki L, Zabl J, Bouwens RJ, Contini T, Garel T, Guiderdoni B, Marino RA, Maseda MV, Matthee JJ, Schaye J, Soucail G. 2019. Faint end of the z ∼ 3–7 luminosity function of Lyman-alpha emitters behind lensing clusters observed with MUSE. Astronomy &#38; Astrophysics. 628, A3.","chicago":"La Vieuville, G. de, D. Bina, R. Pello, G. Mahler, J. Richard, A. B. Drake, E. C. Herenz, et al. “Faint End of the z ∼ 3–7 Luminosity Function of Lyman-Alpha Emitters behind Lensing Clusters Observed with MUSE.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2019. <a href=\"https://doi.org/10.1051/0004-6361/201834471\">https://doi.org/10.1051/0004-6361/201834471</a>.","ieee":"G. de La Vieuville <i>et al.</i>, “Faint end of the z ∼ 3–7 luminosity function of Lyman-alpha emitters behind lensing clusters observed with MUSE,” <i>Astronomy &#38; Astrophysics</i>, vol. 628. EDP Sciences, 2019.","apa":"de La Vieuville, G., Bina, D., Pello, R., Mahler, G., Richard, J., Drake, A. B., … Soucail, G. (2019). Faint end of the z ∼ 3–7 luminosity function of Lyman-alpha emitters behind lensing clusters observed with MUSE. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/201834471\">https://doi.org/10.1051/0004-6361/201834471</a>","mla":"de La Vieuville, G., et al. “Faint End of the z ∼ 3–7 Luminosity Function of Lyman-Alpha Emitters behind Lensing Clusters Observed with MUSE.” <i>Astronomy &#38; Astrophysics</i>, vol. 628, A3, EDP Sciences, 2019, doi:<a href=\"https://doi.org/10.1051/0004-6361/201834471\">10.1051/0004-6361/201834471</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"       628","date_published":"2019-07-25T00:00:00Z","quality_controlled":"1","arxiv":1,"day":"25","doi":"10.1051/0004-6361/201834471","oa":1,"type":"journal_article","main_file_link":[{"url":"https://arxiv.org/abs/1905.13696","open_access":"1"}],"keyword":["Space and Planetary Science","Astronomy and Astrophysics","gravitational lensing: strong / galaxies: high-redshift / dark ages","reionization","first stars / galaxies: clusters: general / galaxies: luminosity function","mass function"],"article_number":"A3","acknowledgement":"We thank the anonymous referee for their critical review and useful suggestions. This work has been carried out thanks to the support of the OCEVU Labex (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02) funded by the “Investissements d’Avenir” French government programme managed by the ANR. Partially funded by the ERC starting grant CALENDS (JR, VP, BC, JM), the Agence Nationale de la recherche bearing the reference ANR-13-BS05-0010-02 (FOGHAR), and the “Programme National de Cosmologie and Galaxies” (PNCG) of CNRS/INSU, France. GdV, RP, JR, GM, JM, BC, and VP also acknowledge support by the Programa de Cooperacion Cientifica – ECOS SUD Program C16U02. NL acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 669253), ABD acknowledges support from the ERC advanced grant “Cosmic Gas”. LW acknowledges support by the Competitive Fund of the Leibniz Association through grant SAW-2015-AIP-2, and TG acknowledges support from the European Research Council under grant agreement ERC-stg-757258 (TRIPLE).. Based on observations made with ESO Telescopes at the La Silla Paranal Observatory under programme IDs 060.A-9345, 094.A-0115, 095.A-0181, 096.A-0710, 097.A0269, 100.A-0249, and 294.A-5032. Also based on observations obtained with the NASA/ESA Hubble Space Telescope, retrieved from the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science Institute (STScI). STScI is operated by the Association of Universities for Research in Astronomy, Inc. under NASA contract NAS 5-26555. This research made use of Astropy, a community-developed core Python package for Astronomy (Astropy Collaboration 2013). All plots in this paper were created using Matplotlib (Hunter 2007).","status":"public","scopus_import":"1","title":"Faint end of the z ∼ 3–7 luminosity function of Lyman-alpha emitters behind lensing clusters observed with MUSE","extern":"1","article_type":"original","language":[{"iso":"eng"}],"publication":"Astronomy & Astrophysics","_id":"11505","author":[{"last_name":"de La Vieuville","full_name":"de La Vieuville, G.","first_name":"G."},{"first_name":"D.","full_name":"Bina, D.","last_name":"Bina"},{"full_name":"Pello, R.","first_name":"R.","last_name":"Pello"},{"first_name":"G.","full_name":"Mahler, G.","last_name":"Mahler"},{"last_name":"Richard","full_name":"Richard, J.","first_name":"J."},{"last_name":"Drake","full_name":"Drake, A. B.","first_name":"A. B."},{"last_name":"Herenz","first_name":"E. C.","full_name":"Herenz, E. C."},{"last_name":"Bauer","first_name":"F. E.","full_name":"Bauer, F. E."},{"last_name":"Clément","first_name":"B.","full_name":"Clément, B."},{"last_name":"Lagattuta","first_name":"D.","full_name":"Lagattuta, D."},{"last_name":"Laporte","first_name":"N.","full_name":"Laporte, N."},{"last_name":"Martinez","full_name":"Martinez, J.","first_name":"J."},{"full_name":"Patrício, V.","first_name":"V.","last_name":"Patrício"},{"last_name":"Wisotzki","full_name":"Wisotzki, L.","first_name":"L."},{"last_name":"Zabl","first_name":"J.","full_name":"Zabl, J."},{"full_name":"Bouwens, R. J.","first_name":"R. J.","last_name":"Bouwens"},{"first_name":"T.","full_name":"Contini, T.","last_name":"Contini"},{"first_name":"T.","full_name":"Garel, T.","last_name":"Garel"},{"last_name":"Guiderdoni","first_name":"B.","full_name":"Guiderdoni, B."},{"last_name":"Marino","full_name":"Marino, R. A.","first_name":"R. A."},{"last_name":"Maseda","full_name":"Maseda, M. V.","first_name":"M. V."},{"full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"full_name":"Schaye, J.","first_name":"J.","last_name":"Schaye"},{"full_name":"Soucail, G.","first_name":"G.","last_name":"Soucail"}],"month":"07","publication_status":"published","date_updated":"2022-07-19T09:36:31Z","year":"2019","volume":628,"abstract":[{"lang":"eng","text":"Contact. This paper presents the results obtained with the Multi-Unit Spectroscopic Explorer (MUSE) at the ESO Very Large Telescope on the faint end of the Lyman-alpha luminosity function (LF) based on deep observations of four lensing clusters. The goal of our project is to set strong constraints on the relative contribution of the Lyman-alpha emitter (LAE) population to cosmic reionization.\r\n\r\nAims. The precise aim of the present study is to further constrain the abundance of LAEs by taking advantage of the magnification provided by lensing clusters to build a blindly selected sample of galaxies which is less biased than current blank field samples in redshift and luminosity. By construction, this sample of LAEs is complementary to those built from deep blank fields, whether observed by MUSE or by other facilities, and makes it possible to determine the shape of the LF at fainter levels, as well as its evolution with redshift.\r\n\r\nMethods. We selected a sample of 156 LAEs with redshifts between 2.9 ≤ z ≤ 6.7 and magnification-corrected luminosities in the range 39 ≲ log LLyα [erg s−1] ≲43. To properly take into account the individual differences in detection conditions between the LAEs when computing the LF, including lensing configurations, and spatial and spectral morphologies, the non-parametric 1/Vmax method was adopted. The price to pay to benefit from magnification is a reduction of the effective volume of the survey, together with a more complex analysis procedure to properly determine the effective volume Vmax for each galaxy. In this paper we present a complete procedure for the determination of the LF based on IFU detections in lensing clusters. This procedure, including some new methods for masking, effective volume integration and (individual) completeness determinations, has been fully automated when possible, and it can be easily generalized to the analysis of IFU observations in blank fields.\r\n\r\nResults. As a result of this analysis, the Lyman-alpha LF has been obtained in four different redshift bins: 2.9 <  z <  6, 7, 2.9 <  z <  4.0, 4.0 <  z <  5.0, and 5.0 <  z <  6.7 with constraints down to log LLyα = 40.5. From our data only, no significant evolution of LF mean slope can be found. When performing a Schechter analysis also including data from the literature to complete the present sample towards the brightest luminosities, a steep faint end slope was measured varying from α = −1.69−0.08+0.08 to α = −1.87−0.12+0.12 between the lowest and the highest redshift bins.\r\n\r\nConclusions. The contribution of the LAE population to the star formation rate density at z ∼ 6 is ≲50% depending on the luminosity limit considered, which is of the same order as the Lyman-break galaxy (LBG) contribution. The evolution of the LAE contribution with redshift depends on the assumed escape fraction of Lyman-alpha photons, and appears to slightly increase with increasing redshift when this fraction is conservatively set to one. Depending on the intersection between the LAE/LBG populations, the contribution of the observed galaxies to the ionizing flux may suffice to keep the universe ionized at z ∼ 6."}],"oa_version":"Published Version","external_id":{"arxiv":["1905.13696"]},"date_created":"2022-07-06T10:09:36Z"},{"external_id":{"arxiv":["1803.08923"]},"date_created":"2022-07-06T11:08:16Z","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Lyman-α (Lyα) is intrinsically the brightest line emitted from active galaxies. While it originates from many physical processes, for star-forming galaxies the intrinsic Lyα luminosity is a direct tracer of the Lyman-continuum (LyC) radiation produced by the most massive O- and early-type B-stars (M⋆ ≳ 10 M⊙) with lifetimes of a few Myrs. As such, Lyα luminosity should be an excellent instantaneous star formation rate (SFR) indicator. However, its resonant nature and susceptibility to dust as a rest-frame UV photon makes Lyα very hard to interpret due to the uncertain Lyα escape fraction, fesc, Lyα. Here we explore results from the CAlibrating LYMan-α with Hα (CALYMHA) survey at z = 2.2, follow-up of Lyα emitters (LAEs) at z = 2.2 − 2.6 and a z ∼ 0−0.3 compilation of LAEs to directly measure fesc, Lyα with Hα. We derive a simple empirical relation that robustly retrieves fesc, Lyα as a function of Lyα rest-frame EW (EW0): fesc,Lyα = 0.0048 EW0[Å] ± 0.05 and we show that it constrains a well-defined anti-correlation between ionisation efficiency (ξion) and dust extinction in LAEs. Observed Lyα luminosities and EW0 are easy measurable quantities at high redshift, thus making our relation a practical tool to estimate intrinsic Lyα and LyC luminosities under well controlled and simple assumptions. Our results allow observed Lyα luminosities to be used to compute SFRs for LAEs at z ∼ 0−2.6 within ±0.2 dex of the Hα dust corrected SFRs. We apply our empirical SFR(Lyα,EW0) calibration to several sources at z ≥ 2.6 to find that star-forming LAEs have SFRs typically ranging from 0.1 to 20 M⊙ yr−1 and that our calibration might be even applicable for the most luminous LAEs within the epoch of re-ionisation. Our results imply high ionisation efficiencies (log10[ξion/Hz erg−1] = 25.4−25.6) and low dust content in LAEs across cosmic time, and will be easily tested with future observations with JWST which can obtain Hα and Hβ measurements for high-redshift LAEs."}],"volume":623,"year":"2019","date_updated":"2022-07-19T09:37:20Z","publication_status":"published","author":[{"full_name":"Sobral, David","first_name":"David","last_name":"Sobral"},{"full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720"}],"month":"03","_id":"11507","language":[{"iso":"eng"}],"publication":"Astronomy & Astrophysics","article_type":"original","extern":"1","title":"Predicting Lyα escape fractions with a simple observable: Lyα in emission as an empirically calibrated star formation rate indicator","status":"public","scopus_import":"1","acknowledgement":"We thank the anonymous referees for multiple comments and suggestions which have improved the manuscript. JM acknowledges the support of a Huygens PhD fellowship from Leiden University. We have benefited greatly from the publicly available programming language PYTHON, including the NUMPY & SCIPY (Van Der Walt et al. 2011; Jones et al. 2001), MATPLOTLIB (Hunter 2007) and ASTROPY (Astropy Collaboration 2013) packages, and the TOPCAT analysis program (Taylor 2013). The results and samples of LAEs used for this paper are publicly available (see e.g. Sobral et al. 2017, 2018a) and we also provide the toy model used as a PYTHON script.","article_number":"A157","keyword":["Space and Planetary Science","Astronomy and Astrophysics","galaxies: high-redshift / galaxies: star formation / galaxies: statistics / galaxies: evolution / galaxies: formation / galaxies: ISM"],"main_file_link":[{"url":"https://arxiv.org/abs/1803.08923","open_access":"1"}],"type":"journal_article","oa":1,"doi":"10.1051/0004-6361/201833075","day":"26","arxiv":1,"quality_controlled":"1","date_published":"2019-03-26T00:00:00Z","intvolume":"       623","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"D. Sobral, J.J. Matthee, Astronomy &#38; Astrophysics 623 (2019).","ama":"Sobral D, Matthee JJ. Predicting Lyα escape fractions with a simple observable: Lyα in emission as an empirically calibrated star formation rate indicator. <i>Astronomy &#38; Astrophysics</i>. 2019;623. doi:<a href=\"https://doi.org/10.1051/0004-6361/201833075\">10.1051/0004-6361/201833075</a>","ista":"Sobral D, Matthee JJ. 2019. Predicting Lyα escape fractions with a simple observable: Lyα in emission as an empirically calibrated star formation rate indicator. Astronomy &#38; Astrophysics. 623, A157.","ieee":"D. Sobral and J. J. Matthee, “Predicting Lyα escape fractions with a simple observable: Lyα in emission as an empirically calibrated star formation rate indicator,” <i>Astronomy &#38; Astrophysics</i>, vol. 623. EDP Sciences, 2019.","chicago":"Sobral, David, and Jorryt J Matthee. “Predicting Lyα Escape Fractions with a Simple Observable: Lyα in Emission as an Empirically Calibrated Star Formation Rate Indicator.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2019. <a href=\"https://doi.org/10.1051/0004-6361/201833075\">https://doi.org/10.1051/0004-6361/201833075</a>.","apa":"Sobral, D., &#38; Matthee, J. J. (2019). Predicting Lyα escape fractions with a simple observable: Lyα in emission as an empirically calibrated star formation rate indicator. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/201833075\">https://doi.org/10.1051/0004-6361/201833075</a>","mla":"Sobral, David, and Jorryt J. Matthee. “Predicting Lyα Escape Fractions with a Simple Observable: Lyα in Emission as an Empirically Calibrated Star Formation Rate Indicator.” <i>Astronomy &#38; Astrophysics</i>, vol. 623, A157, EDP Sciences, 2019, doi:<a href=\"https://doi.org/10.1051/0004-6361/201833075\">10.1051/0004-6361/201833075</a>."},"publisher":"EDP Sciences","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"article_processing_charge":"No"},{"type":"journal_article","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1903.09167"}],"doi":"10.3847/1538-4357/ab3102","oa":1,"article_number":"140","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"acknowledgement":"We are grateful to the referee for providing a constructive report. L.A.B. wants to thank Madusha L.P. Gunawardhana for her help with platefit. Based on observations collected at the European Southern Observatory under ESO programme(s): 094.A-2089(B), 095.A-0010(A), 096.A-0045(A), and 096.A-0045(B). This paper makes use of the following ALMA data: ADS/JAO.ALMA#2016.1.00324.L. ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS (Japan), together with NRC (Canada), NSC and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO, and NAOJ. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.\r\n\r\n\"Este trabajo contó con el apoyo de CONICYT+Programa de Astronomía+ Fondo CHINA-CONICYT\" J.G-L. acknowledges partial support from ALMA-CONICYT project 31160033. F.E.B. acknowledges support from CONICYT grant Basal AFB-170002 (FEB), and the Ministry of Economy, Development, and Tourism's Millennium Science Initiative through grant IC120009, awarded to The Millennium Institute of Astrophysics, MAS (FEB). J.B. acknowledges support by Fundação para a Ciência e a Tecnologia (FCT) through national funds (UID/FIS/04434/2013) and Investigador FCT contract IF/01654/2014/CP1215/CT0003., and by FEDER through COMPETE2020 (POCI-01-0145-FEDER-007672). T.D-S. acknowledges support from ALMA-CONYCIT project 31130005 and FONDECYT project 1151239. J.H. acknowledges support of the VIDI research programme with project number 639.042.611, which is (partly) financed by the Netherlands Organization for Scientific Research (NWO). D.R. acknowledges support from the National Science Foundation under grant No. AST-1614213. I.R.S. acknowledges support from the ERC Advanced Grant DUSTYGAL (321334) and STFC (ST/P000541/1)\r\n\r\nWork on Gnuastro has been funded by the Japanese MEXT scholarship and its Grant-in-Aid for Scientific Research (21244012, 24253003), the ERC advanced grant 339659-MUSICOS, European Union's Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement No. 721463 to the SUNDIAL ITN, and from the Spanish MINECO under grant No. AYA2016-76219-P.","citation":{"ista":"Boogaard LA, Decarli R, González-López J, van der Werf P, Walter F, Bouwens R, Aravena M, Carilli C, Bauer FE, Brinchmann J, Contini T, Cox P, da Cunha E, Daddi E, Díaz-Santos T, Hodge J, Inami H, Ivison R, Maseda M, Matthee JJ, Oesch P, Popping G, Riechers D, Schaye J, Schouws S, Smail I, Weiss A, Wisotzki L, Bacon R, Cortes PC, Rix H-W, Somerville RS, Swinbank M, Wagg J. 2019. The ALMA spectroscopic survey in the HUDF: Nature and physical properties of gas-mass selected galaxies using MUSE spectroscopy. The Astrophysical Journal. 882(2), 140.","ieee":"L. A. Boogaard <i>et al.</i>, “The ALMA spectroscopic survey in the HUDF: Nature and physical properties of gas-mass selected galaxies using MUSE spectroscopy,” <i>The Astrophysical Journal</i>, vol. 882, no. 2. IOP Publishing, 2019.","chicago":"Boogaard, Leindert A., Roberto Decarli, Jorge González-López, Paul van der Werf, Fabian Walter, Rychard Bouwens, Manuel Aravena, et al. “The ALMA Spectroscopic Survey in the HUDF: Nature and Physical Properties of Gas-Mass Selected Galaxies Using MUSE Spectroscopy.” <i>The Astrophysical Journal</i>. IOP Publishing, 2019. <a href=\"https://doi.org/10.3847/1538-4357/ab3102\">https://doi.org/10.3847/1538-4357/ab3102</a>.","apa":"Boogaard, L. A., Decarli, R., González-López, J., van der Werf, P., Walter, F., Bouwens, R., … Wagg, J. (2019). The ALMA spectroscopic survey in the HUDF: Nature and physical properties of gas-mass selected galaxies using MUSE spectroscopy. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ab3102\">https://doi.org/10.3847/1538-4357/ab3102</a>","mla":"Boogaard, Leindert A., et al. “The ALMA Spectroscopic Survey in the HUDF: Nature and Physical Properties of Gas-Mass Selected Galaxies Using MUSE Spectroscopy.” <i>The Astrophysical Journal</i>, vol. 882, no. 2, 140, IOP Publishing, 2019, doi:<a href=\"https://doi.org/10.3847/1538-4357/ab3102\">10.3847/1538-4357/ab3102</a>.","short":"L.A. Boogaard, R. Decarli, J. González-López, P. van der Werf, F. Walter, R. Bouwens, M. Aravena, C. Carilli, F.E. Bauer, J. Brinchmann, T. Contini, P. Cox, E. da Cunha, E. Daddi, T. Díaz-Santos, J. Hodge, H. Inami, R. Ivison, M. Maseda, J.J. Matthee, P. Oesch, G. Popping, D. Riechers, J. Schaye, S. Schouws, I. Smail, A. Weiss, L. Wisotzki, R. Bacon, P.C. Cortes, H.-W. Rix, R.S. Somerville, M. Swinbank, J. Wagg, The Astrophysical Journal 882 (2019).","ama":"Boogaard LA, Decarli R, González-López J, et al. The ALMA spectroscopic survey in the HUDF: Nature and physical properties of gas-mass selected galaxies using MUSE spectroscopy. <i>The Astrophysical Journal</i>. 2019;882(2). doi:<a href=\"https://doi.org/10.3847/1538-4357/ab3102\">10.3847/1538-4357/ab3102</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"2","publisher":"IOP Publishing","article_processing_charge":"No","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"quality_controlled":"1","day":"11","arxiv":1,"intvolume":"       882","date_published":"2019-09-11T00:00:00Z","abstract":[{"text":"We discuss the nature and physical properties of gas-mass selected galaxies in the ALMA spectroscopic survey (ASPECS) of the Hubble Ultra Deep Field (HUDF). We capitalize on the deep optical integral-field spectroscopy from the Multi Unit Spectroscopic Explorer (MUSE) HUDF Survey and multiwavelength data to uniquely associate all 16 line emitters, detected in the ALMA data without preselection, with rotational transitions of carbon monoxide (CO). We identify 10 as CO(2–1) at 1 < z < 2, 5 as CO(3–2) at 2 < z < 3, and 1 as CO(4–3) at z = 3.6. Using the MUSE data as a prior, we identify two additional CO(2–1) emitters, increasing the total sample size to 18. We infer metallicities consistent with (super-)solar for the CO-detected galaxies at z ≤ 1.5, motivating our choice of a Galactic conversion factor between CO luminosity and molecular gas mass for these galaxies. Using deep Chandra imaging of the HUDF, we determine an X-ray AGN fraction of 20% and 60% among the CO emitters at z ∼ 1.4 and z ∼ 2.6, respectively. Being a CO-flux-limited survey, ASPECS-LP detects molecular gas in galaxies on, above, and below the main sequence (MS) at z ∼ 1.4. For stellar masses ≥1010 (1010.5) ${M}_{\\odot }$, we detect about 40% (50%) of all galaxies in the HUDF at 1 < z < 2 (2 < z < 3). The combination of ALMA and MUSE integral-field spectroscopy thus enables an unprecedented view of MS galaxies during the peak of galaxy formation.","lang":"eng"}],"volume":882,"year":"2019","external_id":{"arxiv":["1903.09167"]},"date_created":"2022-07-06T13:31:35Z","oa_version":"Preprint","language":[{"iso":"eng"}],"publication":"The Astrophysical Journal","_id":"11514","title":"The ALMA spectroscopic survey in the HUDF: Nature and physical properties of gas-mass selected galaxies using MUSE spectroscopy","scopus_import":"1","status":"public","article_type":"original","extern":"1","date_updated":"2022-07-19T09:50:55Z","publication_status":"published","month":"09","author":[{"full_name":"Boogaard, Leindert A.","first_name":"Leindert A.","last_name":"Boogaard"},{"last_name":"Decarli","first_name":"Roberto","full_name":"Decarli, Roberto"},{"last_name":"González-López","first_name":"Jorge","full_name":"González-López, Jorge"},{"last_name":"van der Werf","first_name":"Paul","full_name":"van der Werf, Paul"},{"last_name":"Walter","full_name":"Walter, Fabian","first_name":"Fabian"},{"last_name":"Bouwens","first_name":"Rychard","full_name":"Bouwens, Rychard"},{"last_name":"Aravena","first_name":"Manuel","full_name":"Aravena, Manuel"},{"first_name":"Chris","full_name":"Carilli, Chris","last_name":"Carilli"},{"last_name":"Bauer","first_name":"Franz Erik","full_name":"Bauer, Franz Erik"},{"last_name":"Brinchmann","first_name":"Jarle","full_name":"Brinchmann, Jarle"},{"full_name":"Contini, Thierry","first_name":"Thierry","last_name":"Contini"},{"last_name":"Cox","full_name":"Cox, Pierre","first_name":"Pierre"},{"full_name":"da Cunha, Elisabete","first_name":"Elisabete","last_name":"da Cunha"},{"first_name":"Emanuele","full_name":"Daddi, Emanuele","last_name":"Daddi"},{"first_name":"Tanio","full_name":"Díaz-Santos, Tanio","last_name":"Díaz-Santos"},{"full_name":"Hodge, Jacqueline","first_name":"Jacqueline","last_name":"Hodge"},{"first_name":"Hanae","full_name":"Inami, Hanae","last_name":"Inami"},{"first_name":"Rob","full_name":"Ivison, Rob","last_name":"Ivison"},{"last_name":"Maseda","first_name":"Michael","full_name":"Maseda, Michael"},{"full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"first_name":"Pascal","full_name":"Oesch, Pascal","last_name":"Oesch"},{"last_name":"Popping","first_name":"Gergö","full_name":"Popping, Gergö"},{"last_name":"Riechers","first_name":"Dominik","full_name":"Riechers, Dominik"},{"last_name":"Schaye","full_name":"Schaye, Joop","first_name":"Joop"},{"full_name":"Schouws, Sander","first_name":"Sander","last_name":"Schouws"},{"last_name":"Smail","first_name":"Ian","full_name":"Smail, Ian"},{"full_name":"Weiss, Axel","first_name":"Axel","last_name":"Weiss"},{"last_name":"Wisotzki","first_name":"Lutz","full_name":"Wisotzki, Lutz"},{"last_name":"Bacon","full_name":"Bacon, Roland","first_name":"Roland"},{"full_name":"Cortes, Paulo C.","first_name":"Paulo C.","last_name":"Cortes"},{"last_name":"Rix","first_name":"Hans-Walter","full_name":"Rix, Hans-Walter"},{"last_name":"Somerville","first_name":"Rachel S.","full_name":"Somerville, Rachel S."},{"full_name":"Swinbank, Mark","first_name":"Mark","last_name":"Swinbank"},{"first_name":"Jeff","full_name":"Wagg, Jeff","last_name":"Wagg"}]},{"type":"journal_article","main_file_link":[{"url":"https://arxiv.org/abs/1903.08171","open_access":"1"}],"doi":"10.3847/1538-4357/ab2f81","oa":1,"article_number":"124","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"acknowledgement":"We thank the anonymous referee for constructive comments and suggestions. We thank Max Gronke for comments on an earlier version of this paper. L.V. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 746119. This paper makes use of the following ALMA data: ADS/JAO.ALMA#2017.1.01451.S. ALMA is a partnership of ESO (representing its member states), NSF (USA), and NINS (Japan), together with NRC (Canada), NSC and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO, and NAOJ. Based on observations obtained with the Very Large Telescope, programs 294.A-5018, 097.A-0943, and 99.A-0462. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained (from the Data Archive) at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with program No. 14699.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Matthee JJ, Sobral D, Boogaard LA, et al. Resolved UV and [C ii] structures of luminous galaxies within the epoch of reionization. <i>The Astrophysical Journal</i>. 2019;881(2). doi:<a href=\"https://doi.org/10.3847/1538-4357/ab2f81\">10.3847/1538-4357/ab2f81</a>","short":"J.J. Matthee, D. Sobral, L.A. Boogaard, H. Röttgering, L. Vallini, A. Ferrara, A. Paulino-Afonso, F. Boone, D. Schaerer, B. Mobasher, The Astrophysical Journal 881 (2019).","mla":"Matthee, Jorryt J., et al. “Resolved UV and [C Ii] Structures of Luminous Galaxies within the Epoch of Reionization.” <i>The Astrophysical Journal</i>, vol. 881, no. 2, 124, IOP Publishing, 2019, doi:<a href=\"https://doi.org/10.3847/1538-4357/ab2f81\">10.3847/1538-4357/ab2f81</a>.","ieee":"J. J. Matthee <i>et al.</i>, “Resolved UV and [C ii] structures of luminous galaxies within the epoch of reionization,” <i>The Astrophysical Journal</i>, vol. 881, no. 2. IOP Publishing, 2019.","apa":"Matthee, J. J., Sobral, D., Boogaard, L. A., Röttgering, H., Vallini, L., Ferrara, A., … Mobasher, B. (2019). Resolved UV and [C ii] structures of luminous galaxies within the epoch of reionization. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ab2f81\">https://doi.org/10.3847/1538-4357/ab2f81</a>","chicago":"Matthee, Jorryt J, D. Sobral, L. A. Boogaard, H. Röttgering, L. Vallini, A. Ferrara, A. Paulino-Afonso, F. Boone, D. Schaerer, and B. Mobasher. “Resolved UV and [C Ii] Structures of Luminous Galaxies within the Epoch of Reionization.” <i>The Astrophysical Journal</i>. IOP Publishing, 2019. <a href=\"https://doi.org/10.3847/1538-4357/ab2f81\">https://doi.org/10.3847/1538-4357/ab2f81</a>.","ista":"Matthee JJ, Sobral D, Boogaard LA, Röttgering H, Vallini L, Ferrara A, Paulino-Afonso A, Boone F, Schaerer D, Mobasher B. 2019. Resolved UV and [C ii] structures of luminous galaxies within the epoch of reionization. The Astrophysical Journal. 881(2), 124."},"publisher":"IOP Publishing","issue":"2","article_processing_charge":"No","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"quality_controlled":"1","arxiv":1,"day":"21","intvolume":"       881","date_published":"2019-08-21T00:00:00Z","abstract":[{"text":"We present new deep ALMA and Hubble Space Telescope (HST)/WFC3 observations of MASOSA and VR7, two luminous Lyα emitters (LAEs) at z = 6.5, for which the UV continuum levels differ by a factor of four. No IR dust continuum emission is detected in either, indicating little amounts of obscured star formation and/or high dust temperatures. MASOSA, with a UV luminosity M1500 = −20.9, compact size, and very high Lyα ${\\mathrm{EW}}_{0}\\approx 145\\,\\mathring{\\rm A} $, is undetected in [C ii] to a limit of L[C ii] < 2.2 × 107 L⊙, implying a metallicity Z ≲ 0.07 Z⊙. Intriguingly, our HST data indicate a red UV slope β = −1.1 ± 0.7, at odds with the low dust content. VR7, which is a bright (M1500 = −22.4) galaxy with moderate color (β = −1.4 ± 0.3) and Lyα EW0 = 34 Å, is clearly detected in [C ii] emission (S/N = 15). VR7's rest-frame UV morphology can be described by two components separated by ≈1.5 kpc and is globally more compact than the [C ii] emission. The global [C ii]/UV ratio indicates Z ≈ 0.2 Z⊙, but there are large variations in the UV/[C ii] ratio on kiloparsec scales. We also identify diffuse, possibly outflowing, [C ii]-emitting gas at ≈100 km s−1 with respect to the peak. VR7 appears to be assembling its components at a slightly more evolved stage than other luminous LAEs, with outflows already shaping its direct environment at z ∼ 7. Our results further indicate that the global [C ii]−UV relation steepens at SFR < 30 M⊙ yr−1, naturally explaining why the [C ii]/UV ratio is anticorrelated with Lyα EW in many, but not all, observed LAEs.","lang":"eng"}],"volume":881,"year":"2019","external_id":{"arxiv":["1903.08171"]},"date_created":"2022-07-06T13:38:15Z","oa_version":"Preprint","publication":"The Astrophysical Journal","language":[{"iso":"eng"}],"_id":"11515","title":"Resolved UV and [C ii] structures of luminous galaxies within the epoch of reionization","status":"public","scopus_import":"1","article_type":"original","extern":"1","date_updated":"2024-10-14T11:32:02Z","publication_status":"published","month":"08","author":[{"full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"first_name":"D.","full_name":"Sobral, D.","last_name":"Sobral"},{"last_name":"Boogaard","full_name":"Boogaard, L. A.","first_name":"L. A."},{"last_name":"Röttgering","full_name":"Röttgering, H.","first_name":"H."},{"full_name":"Vallini, L.","first_name":"L.","last_name":"Vallini"},{"first_name":"A.","full_name":"Ferrara, A.","last_name":"Ferrara"},{"first_name":"A.","full_name":"Paulino-Afonso, A.","last_name":"Paulino-Afonso"},{"last_name":"Boone","full_name":"Boone, F.","first_name":"F."},{"first_name":"D.","full_name":"Schaerer, D.","last_name":"Schaerer"},{"last_name":"Mobasher","full_name":"Mobasher, B.","first_name":"B."}]},{"publication_status":"published","date_updated":"2022-08-18T10:20:18Z","author":[{"full_name":"Marino, Raffaella Anna","first_name":"Raffaella Anna","last_name":"Marino"},{"last_name":"Cantalupo","first_name":"Sebastiano","full_name":"Cantalupo, Sebastiano"},{"first_name":"Gabriele","full_name":"Pezzulli, Gabriele","last_name":"Pezzulli"},{"full_name":"Lilly, Simon J.","first_name":"Simon J.","last_name":"Lilly"},{"full_name":"Gallego, Sofia","first_name":"Sofia","last_name":"Gallego"},{"full_name":"Mackenzie, Ruari","first_name":"Ruari","last_name":"Mackenzie"},{"orcid":"0000-0003-2871-127X","first_name":"Jorryt J","full_name":"Matthee, Jorryt J","last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"last_name":"Brinchmann","first_name":"Jarle","full_name":"Brinchmann, Jarle"},{"first_name":"Nicolas","full_name":"Bouché, Nicolas","last_name":"Bouché"},{"first_name":"Anna","full_name":"Feltre, Anna","last_name":"Feltre"},{"first_name":"Sowgat","full_name":"Muzahid, Sowgat","last_name":"Muzahid"},{"full_name":"Schroetter, Ilane","first_name":"Ilane","last_name":"Schroetter"},{"first_name":"Sean D.","full_name":"Johnson, Sean D.","last_name":"Johnson"},{"last_name":"Nanayakkara","first_name":"Themiya","full_name":"Nanayakkara, Themiya"}],"month":"07","publication":"The Astrophysical Journal","language":[{"iso":"eng"}],"_id":"11516","scopus_import":"1","status":"public","title":"A giant Lyα nebula and a small-scale clumpy outflow in the system of the exotic quasar J0952+0114 unveiled by MUSE","extern":"1","article_type":"original","external_id":{"arxiv":["1906.06347"]},"date_created":"2022-07-06T13:50:33Z","oa_version":"Preprint","abstract":[{"text":"The well-known quasar SDSS J095253.83+011421.9 (J0952+0114) at z = 3.02 has one of the most peculiar spectra discovered so far, showing the presence of narrow Lyα and broad metal emission lines. Although recent studies have suggested that a proximate damped Lyα absorption (PDLA) system causes this peculiar spectrum, the origin of the gas associated with the PDLA is unknown. Here we report the results of observations with the Multi Unit Spectroscopic Explorer (MUSE) that reveal a new giant (≈100 physical kpc) Lyα nebula. The detailed analysis of the Lyα velocity, velocity dispersion, and surface brightness profiles suggests that the J0952+0114 Lyα nebula shares similar properties with other QSO nebulae previously detected with MUSE, implying that the PDLA in J0952+0144 is covering only a small fraction of the solid angle of the QSO emission. We also detected bright and spectrally narrow C iv λ1550 and He ii λ1640 extended emission around J0952+0114 with velocity centroids similar to the peak of the extended and central narrow Lyα emission. The presence of a peculiarly bright, unresolved, and relatively broad He ii λ1640 emission in the central region at exactly the same PDLA redshift hints at the possibility that the PDLA originates in a clumpy outflow with a bulk velocity of about 500 km s−1. The smaller velocity dispersion of the large-scale Lyα emission suggests that the high-speed outflow is confined to the central region. Lastly, the derived spatially resolved He ii/Lyα and C iv/Lyα maps show a positive gradient with the distance to the QSO, hinting at a non-homogeneous distribution of the ionization parameter.","lang":"eng"}],"year":"2019","volume":880,"quality_controlled":"1","day":"24","arxiv":1,"intvolume":"       880","date_published":"2019-07-24T00:00:00Z","issue":"1","publisher":"IOP Publishing","citation":{"mla":"Marino, Raffaella Anna, et al. “A Giant Lyα Nebula and a Small-Scale Clumpy Outflow in the System of the Exotic Quasar J0952+0114 Unveiled by MUSE.” <i>The Astrophysical Journal</i>, vol. 880, no. 1, 47, IOP Publishing, 2019, doi:<a href=\"https://doi.org/10.3847/1538-4357/ab2881\">10.3847/1538-4357/ab2881</a>.","apa":"Marino, R. A., Cantalupo, S., Pezzulli, G., Lilly, S. J., Gallego, S., Mackenzie, R., … Nanayakkara, T. (2019). A giant Lyα nebula and a small-scale clumpy outflow in the system of the exotic quasar J0952+0114 unveiled by MUSE. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ab2881\">https://doi.org/10.3847/1538-4357/ab2881</a>","ieee":"R. A. Marino <i>et al.</i>, “A giant Lyα nebula and a small-scale clumpy outflow in the system of the exotic quasar J0952+0114 unveiled by MUSE,” <i>The Astrophysical Journal</i>, vol. 880, no. 1. IOP Publishing, 2019.","chicago":"Marino, Raffaella Anna, Sebastiano Cantalupo, Gabriele Pezzulli, Simon J. Lilly, Sofia Gallego, Ruari Mackenzie, Jorryt J Matthee, et al. “A Giant Lyα Nebula and a Small-Scale Clumpy Outflow in the System of the Exotic Quasar J0952+0114 Unveiled by MUSE.” <i>The Astrophysical Journal</i>. IOP Publishing, 2019. <a href=\"https://doi.org/10.3847/1538-4357/ab2881\">https://doi.org/10.3847/1538-4357/ab2881</a>.","ista":"Marino RA, Cantalupo S, Pezzulli G, Lilly SJ, Gallego S, Mackenzie R, Matthee JJ, Brinchmann J, Bouché N, Feltre A, Muzahid S, Schroetter I, Johnson SD, Nanayakkara T. 2019. A giant Lyα nebula and a small-scale clumpy outflow in the system of the exotic quasar J0952+0114 unveiled by MUSE. The Astrophysical Journal. 880(1), 47.","ama":"Marino RA, Cantalupo S, Pezzulli G, et al. A giant Lyα nebula and a small-scale clumpy outflow in the system of the exotic quasar J0952+0114 unveiled by MUSE. <i>The Astrophysical Journal</i>. 2019;880(1). doi:<a href=\"https://doi.org/10.3847/1538-4357/ab2881\">10.3847/1538-4357/ab2881</a>","short":"R.A. Marino, S. Cantalupo, G. Pezzulli, S.J. Lilly, S. Gallego, R. Mackenzie, J.J. Matthee, J. Brinchmann, N. Bouché, A. Feltre, S. Muzahid, I. Schroetter, S.D. Johnson, T. Nanayakkara, The Astrophysical Journal 880 (2019)."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","publication_identifier":{"eissn":["1538-4357"],"issn":["0004-637X"]},"keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"article_number":"47","acknowledgement":"We thank Lutz Wisotzki for stimulating discussions. This work is based on observations taken at ESO/VLT in Paranal and we would like to thank the ESO staff for their assistance and support during the MUSE GTO campaigns. This work was supported by the Swiss National Science Foundation. This research made use of Astropy, a community-developed core PYTHON package for astronomy (Astropy Collaboration et al. 2013), NumPy and SciPy (Oliphant 2007), Matplotlib (Hunter 2007), IPython (Perez & Granger 2007), and of the NASA Astrophysics Data System Bibliographic Services. S.C. and G.P. gratefully acknowledge support from Swiss National Science Foundation grant PP00P2−163824. A.F. acknowledges support from the ERC via Advanced Grant under grants agreement no. 339659-MUSICOS. J.B. acknowledges support by FCT/MCTES through national funds by grant UID/FIS/04434/2019 and through Investigador FCT Contract No. IF/01654/2014/CP1215/CT0003. S.D.J. is supported by a NASA Hubble Fellowship (HST-HF2-51375.001-A). T.N. acknowledges the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) top grant TOP1.16.057.","type":"journal_article","main_file_link":[{"url":"https://arxiv.org/abs/1906.06347","open_access":"1"}],"doi":"10.3847/1538-4357/ab2881","oa":1}]