[{"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1016/j.cels.2025.101488","oa_version":"Published Version","publication_status":"published","language":[{"iso":"eng"}],"abstract":[{"text":"In aged humans and mice, hypobranched glycogen aggregates, known as polyglucosan bodies (PGBs), accumulate in hippocampal astrocytes. While PGBs are linked to cognitive decline in neurological diseases, they remain largely unstudied in the context of typical aging. We show that PGBs arise in autophagy-dysregulated astrocytes in the aged hippocampus, with substantial variation among 32 inbred BXD mouse strains. Genetic mapping through quantitative trait locus analysis identified a major locus (Pgb1) that modulates hippocampal PGB burden. Extensive transcriptomic and proteomic datasets were produced for the aged hippocampus of the BXD family to investigate the mechanism by which the Pgb1 locus modulates PGB burden. We identified that Pgb1 contains allelic Smarcal1 and Usp37 variants and influences PGB burden through trans-regulation of mRNA and protein expression levels, including abundance of glycogen-mobilizing factor PYGB. Furthermore, comprehensive phenome-wide association scans, transcriptomic analyses, and direct behavioral testing demonstrated that cognition remains intact despite age-related PGB burden. A record of this paper’s transparent peer review process is included in the supplemental information.","lang":"eng"}],"type":"journal_article","month":"02","status":"public","intvolume":"        17","author":[{"last_name":"Gómez-Pascual","full_name":"Gómez-Pascual, Alicia","first_name":"Alicia"},{"first_name":"Dow M","full_name":"Glikman, Dow M","last_name":"Glikman","id":"ab8acda1-91c1-11f0-aad8-f75d3d6424d8"},{"last_name":"Ng","full_name":"Ng, Hui Xin","first_name":"Hui Xin"},{"last_name":"Tomkins","full_name":"Tomkins, James E.","first_name":"James E."},{"full_name":"Lu, Lu","first_name":"Lu","last_name":"Lu"},{"last_name":"Xu","full_name":"Xu, Ying","first_name":"Ying"},{"full_name":"Ashbrook, David G.","first_name":"David G.","last_name":"Ashbrook"},{"full_name":"Kaczorowski, Catherine","first_name":"Catherine","last_name":"Kaczorowski"},{"last_name":"Kempermann","full_name":"Kempermann, Gerd","first_name":"Gerd"},{"last_name":"Killmar","first_name":"John","full_name":"Killmar, John"},{"first_name":"Khyobeni","full_name":"Mozhui, Khyobeni","last_name":"Mozhui"},{"last_name":"Ohlenschläger","first_name":"Oliver","full_name":"Ohlenschläger, Oliver"},{"last_name":"Aebersold","full_name":"Aebersold, Rudolf","first_name":"Rudolf"},{"last_name":"Ingram","full_name":"Ingram, Donald K.","first_name":"Donald K."},{"first_name":"Evan G.","full_name":"Williams, Evan G.","last_name":"Williams"},{"first_name":"Mathias","full_name":"Jucker, Mathias","last_name":"Jucker"},{"first_name":"Rupert W.","full_name":"Overall, Rupert W.","last_name":"Overall"},{"full_name":"Williams, Robert W.","first_name":"Robert W.","last_name":"Williams"},{"last_name":"de Bakker","full_name":"de Bakker, Dennis E.M.","first_name":"Dennis E.M."}],"date_published":"2026-02-18T00:00:00Z","file_date_updated":"2026-02-23T10:32:12Z","scopus_import":"1","has_accepted_license":"1","article_type":"original","date_updated":"2026-02-23T10:35:01Z","title":"The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus","day":"18","publication":"Cell Systems","ddc":["570"],"OA_place":"publisher","_id":"21234","article_number":"101488","file":[{"file_name":"2026_CellSystems_GomezPascual.pdf","success":1,"file_size":10606778,"date_updated":"2026-02-23T10:32:12Z","checksum":"920e8edfd3b8b42f5bb6f86d4c66c54d","date_created":"2026-02-23T10:32:12Z","relation":"main_file","content_type":"application/pdf","access_level":"open_access","file_id":"21349","creator":"dernst"}],"license":"https://creativecommons.org/licenses/by/4.0/","department":[{"_id":"GradSch"}],"publisher":"Elsevier","OA_type":"hybrid","quality_controlled":"1","article_processing_charge":"No","issue":"2","citation":{"ista":"Gómez-Pascual A, Glikman DM, Ng HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski C, Kempermann G, Killmar J, Mozhui K, Ohlenschläger O, Aebersold R, Ingram DK, Williams EG, Jucker M, Overall RW, Williams RW, de Bakker DEM. 2026. The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. Cell Systems. 17(2), 101488.","mla":"Gómez-Pascual, Alicia, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>, vol. 17, no. 2, 101488, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.cels.2025.101488\">10.1016/j.cels.2025.101488</a>.","chicago":"Gómez-Pascual, Alicia, Dow M Glikman, Hui Xin Ng, James E. Tomkins, Lu Lu, Ying Xu, David G. Ashbrook, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.cels.2025.101488\">https://doi.org/10.1016/j.cels.2025.101488</a>.","apa":"Gómez-Pascual, A., Glikman, D. M., Ng, H. X., Tomkins, J. E., Lu, L., Xu, Y., … de Bakker, D. E. M. (2026). The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cels.2025.101488\">https://doi.org/10.1016/j.cels.2025.101488</a>","ieee":"A. Gómez-Pascual <i>et al.</i>, “The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus,” <i>Cell Systems</i>, vol. 17, no. 2. Elsevier, 2026.","short":"A. Gómez-Pascual, D.M. Glikman, H.X. Ng, J.E. Tomkins, L. Lu, Y. Xu, D.G. Ashbrook, C. Kaczorowski, G. Kempermann, J. Killmar, K. Mozhui, O. Ohlenschläger, R. Aebersold, D.K. Ingram, E.G. Williams, M. Jucker, R.W. Overall, R.W. Williams, D.E.M. de Bakker, Cell Systems 17 (2026).","ama":"Gómez-Pascual A, Glikman DM, Ng HX, et al. The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>. 2026;17(2). doi:<a href=\"https://doi.org/10.1016/j.cels.2025.101488\">10.1016/j.cels.2025.101488</a>"},"oa":1,"volume":17,"publication_identifier":{"issn":["2405-4712"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-02-16T10:45:10Z","pmid":1,"PlanS_conform":"1","external_id":{"pmid":["41633365"]},"year":"2026","acknowledgement":"We would like to thank the Summer School Systems Genetics of Neural Ageing for bringing us together and spurring our international collaboration. We would also like to acknowledge the funding for the Summer School 2022 from the e:Med Systems Medicine Program of the BMBF (Bundesministerium für Bildung und Forschung; German Ministry of Education and Research) to R.W.O. In addition, we would like to thank the FLI imaging core facility for their assistance. A.G.-P. is supported by Fundación Séneca, Región de Murcia, Spain (21259/FPI/19). D.E.M.d.B. is financed by a Rubicon scholarship (452021116) from the Dutch Research Council (NWO). This work was also supported by NIH NIA R01AG070913-01 (R.W.W.), R01AG075813-01 (D.G.A.), and R01AG075818 (C.K.). We acknowledge the help of Larry Mobraaten (Jackson Laboratory, Bar Harbor, MN) with the BXD strains and U. Obermüller for the help with the histology. For the purpose of open access, the authors have applied a CC BY public copyright license to all author-accepted manuscripts arising from this submission."},{"arxiv":1,"language":[{"iso":"eng"}],"publication_status":"published","doi":"10.2140/pjm.2026.340.179","oa_version":"Preprint","intvolume":"       340","month":"01","status":"public","abstract":[{"text":"We obtain an asymptotic formula for the number of integral solutions to a system of diagonal equations. We obtain an asymptotic formula for the number of solutions with variables restricted to smooth numbers as well. We improve the required number of variables compared to previous results by incorporating recent progress on Waring’s problem and the resolution of the main conjecture in Vinogradov’s mean value theorem.","lang":"eng"}],"type":"journal_article","date_published":"2026-01-01T00:00:00Z","author":[{"full_name":"Rome, Nick","first_name":"Nick","last_name":"Rome"},{"last_name":"Yamagishi","id":"0c3fbc5c-f7a6-11ec-8d70-9485e75b416b","first_name":"Shuntaro","full_name":"Yamagishi, Shuntaro"}],"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2406.09256","open_access":"1"}],"day":"01","article_type":"original","date_updated":"2026-02-17T11:43:14Z","title":"Integral solutions to systems of diagonal equations","OA_place":"repository","publication":"Pacific Journal of Mathematics","_id":"21242","citation":{"ama":"Rome N, Yamagishi S. Integral solutions to systems of diagonal equations. <i>Pacific Journal of Mathematics</i>. 2026;340(1):179-198. doi:<a href=\"https://doi.org/10.2140/pjm.2026.340.179\">10.2140/pjm.2026.340.179</a>","short":"N. Rome, S. Yamagishi, Pacific Journal of Mathematics 340 (2026) 179–198.","ieee":"N. Rome and S. Yamagishi, “Integral solutions to systems of diagonal equations,” <i>Pacific Journal of Mathematics</i>, vol. 340, no. 1. Mathematical Sciences Publishers, pp. 179–198, 2026.","apa":"Rome, N., &#38; Yamagishi, S. (2026). Integral solutions to systems of diagonal equations. <i>Pacific Journal of Mathematics</i>. Mathematical Sciences Publishers. <a href=\"https://doi.org/10.2140/pjm.2026.340.179\">https://doi.org/10.2140/pjm.2026.340.179</a>","chicago":"Rome, Nick, and Shuntaro Yamagishi. “Integral Solutions to Systems of Diagonal Equations.” <i>Pacific Journal of Mathematics</i>. Mathematical Sciences Publishers, 2026. <a href=\"https://doi.org/10.2140/pjm.2026.340.179\">https://doi.org/10.2140/pjm.2026.340.179</a>.","mla":"Rome, Nick, and Shuntaro Yamagishi. “Integral Solutions to Systems of Diagonal Equations.” <i>Pacific Journal of Mathematics</i>, vol. 340, no. 1, Mathematical Sciences Publishers, 2026, pp. 179–98, doi:<a href=\"https://doi.org/10.2140/pjm.2026.340.179\">10.2140/pjm.2026.340.179</a>.","ista":"Rome N, Yamagishi S. 2026. Integral solutions to systems of diagonal equations. Pacific Journal of Mathematics. 340(1), 179–198."},"oa":1,"volume":340,"issue":"1","quality_controlled":"1","article_processing_charge":"No","OA_type":"green","page":"179-198","publisher":"Mathematical Sciences Publishers","department":[{"_id":"TiBr"}],"year":"2026","external_id":{"arxiv":["2406.09256"]},"date_created":"2026-02-16T15:17:27Z","publication_identifier":{"issn":["0030-8730"],"eissn":["1945-5844"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"date_published":"2026-01-21T00:00:00Z","author":[{"full_name":"Dombret, Albert","first_name":"Albert","last_name":"Dombret"},{"first_name":"Adrien","full_name":"Sutter, Adrien","last_name":"Sutter"},{"orcid":"0000-0001-5524-596X","first_name":"Baptiste","full_name":"Coquinot, Baptiste","last_name":"Coquinot","id":"f8417bd4-f599-11ee-a482-b927e3ed1e8e"},{"first_name":"Nikita","full_name":"Kavokine, Nikita","last_name":"Kavokine"},{"first_name":"Benoit","full_name":"Coasne, Benoit","last_name":"Coasne"},{"last_name":"Bocquet","first_name":"Lydéric","full_name":"Bocquet, Lydéric"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2512.11368"}],"article_type":"original","date_updated":"2026-02-23T12:01:57Z","title":"Hydrodynamic permeability of fluctuating porous membranes","day":"21","publication_status":"published","doi":"10.1103/m8h6-1wfk","oa_version":"Preprint","arxiv":1,"language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"lang":"eng","text":"In this paper we examine how porosity fluctuations affect the hydrodynamic permeability of a porous matrix or membrane. We introduce a fluctuating Darcy model, which couples the Navier-Stokes equation to the space- and time-dependent porosity fluctuations via a Darcy friction term. Using a perturbative approach, a Dyson equation for hydrodynamic fluctuations is derived and solved to express the permeability in terms of the matrix fluctuation spectrum. Surprisingly, the model reveals strong modifications of the fluid permeability in fluctuating matrices compared to static ones. Applications to various matrix excitation models, the breathing matrix, phonons, and active forcing, highlight the significant influence of matrix fluctuations on fluid transport, offering insights for optimizing membrane design for separation applications."}],"intvolume":"        11","month":"01","status":"public","quality_controlled":"1","article_processing_charge":"No","OA_type":"green","department":[{"_id":"MiLe"}],"publisher":"American Physical Society","citation":{"ista":"Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. 2026. Hydrodynamic permeability of fluctuating porous membranes. Physical Review Fluids. 11(1), 014201.","chicago":"Dombret, Albert, Adrien Sutter, Baptiste Coquinot, Nikita Kavokine, Benoit Coasne, and Lydéric Bocquet. “Hydrodynamic Permeability of Fluctuating Porous Membranes.” <i>Physical Review Fluids</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/m8h6-1wfk\">https://doi.org/10.1103/m8h6-1wfk</a>.","mla":"Dombret, Albert, et al. “Hydrodynamic Permeability of Fluctuating Porous Membranes.” <i>Physical Review Fluids</i>, vol. 11, no. 1, 014201, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/m8h6-1wfk\">10.1103/m8h6-1wfk</a>.","ieee":"A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, and L. Bocquet, “Hydrodynamic permeability of fluctuating porous membranes,” <i>Physical Review Fluids</i>, vol. 11, no. 1. American Physical Society, 2026.","apa":"Dombret, A., Sutter, A., Coquinot, B., Kavokine, N., Coasne, B., &#38; Bocquet, L. (2026). Hydrodynamic permeability of fluctuating porous membranes. <i>Physical Review Fluids</i>. American Physical Society. <a href=\"https://doi.org/10.1103/m8h6-1wfk\">https://doi.org/10.1103/m8h6-1wfk</a>","ama":"Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. Hydrodynamic permeability of fluctuating porous membranes. <i>Physical Review Fluids</i>. 2026;11(1). doi:<a href=\"https://doi.org/10.1103/m8h6-1wfk\">10.1103/m8h6-1wfk</a>","short":"A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, L. Bocquet, Physical Review Fluids 11 (2026)."},"oa":1,"volume":11,"issue":"1","date_created":"2026-02-17T08:10:09Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2469-990X"]},"year":"2026","acknowledgement":"The authors acknowledge support from ERC project n-AQUA, Grant Agreement No. 101071937.\r\nB.C. and A.S. acknowledge support from the CFM Foundation. B.C. acknowledges support from\r\nthe NOMIS Foundation.","external_id":{"arxiv":["2512.11368"]},"publication":"Physical Review Fluids","corr_author":"1","OA_place":"repository","_id":"21273","article_number":"014201"},{"_id":"21275","article_number":"013018","corr_author":"1","publication":"PRX Life","OA_place":"publisher","ddc":["570"],"date_created":"2026-02-17T08:17:53Z","publication_identifier":{"eissn":["2835-8279"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This project has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No. 950349 and the Marie Skłodowska-Curie Grant Agreement No. 101034413. The computations in this paper were run in part on the the FASRC Cannon cluster supported by the FAS Division of Science Research Computing Group at Harvard University and the cluster of the Max Planck Institute for the Physics of Complex Systems.","year":"2026","PlanS_conform":"1","article_processing_charge":"Yes","quality_controlled":"1","OA_type":"gold","file":[{"file_name":"2026_PRXLife_Olmeda.pdf","success":1,"file_size":5857833,"date_updated":"2026-02-24T06:53:05Z","date_created":"2026-02-24T06:53:05Z","checksum":"df9776422862d1d02c66d98e2d620849","relation":"main_file","creator":"dernst","content_type":"application/pdf","access_level":"open_access","file_id":"21351"}],"department":[{"_id":"EdHa"}],"publisher":"American Physical Society","oa":1,"volume":4,"citation":{"ieee":"F. Olmeda, M. Gupta, O. Bektas, and S. Rulands, “Spatiotemporal patterns of active epigenetic turnover,” <i>PRX Life</i>, vol. 4. American Physical Society, 2026.","apa":"Olmeda, F., Gupta, M., Bektas, O., &#38; Rulands, S. (2026). Spatiotemporal patterns of active epigenetic turnover. <i>PRX Life</i>. American Physical Society. <a href=\"https://doi.org/10.1103/89bj-79g5\">https://doi.org/10.1103/89bj-79g5</a>","short":"F. Olmeda, M. Gupta, O. Bektas, S. Rulands, PRX Life 4 (2026).","ama":"Olmeda F, Gupta M, Bektas O, Rulands S. Spatiotemporal patterns of active epigenetic turnover. <i>PRX Life</i>. 2026;4. doi:<a href=\"https://doi.org/10.1103/89bj-79g5\">10.1103/89bj-79g5</a>","ista":"Olmeda F, Gupta M, Bektas O, Rulands S. 2026. Spatiotemporal patterns of active epigenetic turnover. PRX Life. 4, 013018.","mla":"Olmeda, Fabrizio, et al. “Spatiotemporal Patterns of Active Epigenetic Turnover.” <i>PRX Life</i>, vol. 4, 013018, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/89bj-79g5\">10.1103/89bj-79g5</a>.","chicago":"Olmeda, Fabrizio, Misha Gupta, Onurcan Bektas, and Steffen Rulands. “Spatiotemporal Patterns of Active Epigenetic Turnover.” <i>PRX Life</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/89bj-79g5\">https://doi.org/10.1103/89bj-79g5</a>."},"project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020","grant_number":"101034413"}],"abstract":[{"text":"DNA methylation is a primary layer of epigenetic modification that plays a pivotal role in the regulation of development, aging, and cancer. The concurrent activity of opposing enzymes that mediate DNA methylation and demethylation gives rise to a biochemical cycle and active turnover of DNA methylation. While the ensuing biochemical oscillations have been implicated in the regulation of cell differentiation, their functional role and spatiotemporal dynamics are unknown. In this work, we demonstrate that chromatin-mediated coupling between these local biochemical cycles can lead to the emergence of phase-locked domains, regions of locally synchronized turnover activity, whose coarsening is arrested by genomic heterogeneity. We introduce a minimal model based on stochastic oscillators with constrained long-range and nonreciprocal interactions, shaped by the local chromatin organization. Through a combination of analytical theory and stochastic simulations, we predict both the degree of synchronization and the typical size of emergent phase-locked domains. We qualitatively test these predictions using single-cell sequencing data. Our results show that DNA methylation turnover exhibits surprisingly rich spatiotemporal patterns that may be used by cells to control cell differentiation.","lang":"eng"}],"type":"journal_article","intvolume":"         4","status":"public","month":"02","publication_status":"published","oa_version":"Published Version","doi":"10.1103/89bj-79g5","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"DOAJ_listed":"1","language":[{"iso":"eng"}],"date_updated":"2026-02-24T06:54:32Z","title":"Spatiotemporal patterns of active epigenetic turnover","article_type":"original","day":"09","file_date_updated":"2026-02-24T06:53:05Z","date_published":"2026-02-09T00:00:00Z","author":[{"last_name":"Olmeda","id":"69dbf5fb-8a76-11ed-866b-fb486d8b5689","first_name":"Fabrizio","full_name":"Olmeda, Fabrizio"},{"last_name":"Gupta","first_name":"Misha","full_name":"Gupta, Misha"},{"last_name":"Bektas","first_name":"Onurcan","full_name":"Bektas, Onurcan"},{"full_name":"Rulands, Steffen","first_name":"Steffen","last_name":"Rulands"}],"ec_funded":1,"has_accepted_license":"1"},{"arxiv":1,"language":[{"iso":"eng"}],"DOAJ_listed":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1103/fdcf-dkws","oa_version":"Published Version","publication_status":"published","month":"01","status":"public","intvolume":"         4","type":"journal_article","abstract":[{"text":"Developmental patterning comprises processes that range from purely instructed, where external signals specify cell fates, to fully self-organized, where spatial patterns emerge autonomously through cellular interactions. We propose that both extremes—as well as the continuum of intermediate cases—can be conceptualized as information-processing systems, whose operation can be described using “Marr's three levels of analysis”: the computational problem being solved, the algorithms employed, and their molecular implementation. At the first level, we argue that normative theories, such as information-theoretic optimization principles, provide a formalization of the computational problem. At the second level, we show how simplified information-processing architectures provide a framework for developmental algorithms, which are formalized mathematically using dynamical systems theory. At the third level, the implementation of developmental algorithms is described by mechanistic biophysical and gene regulatory network models.","lang":"eng"}],"has_accepted_license":"1","author":[{"id":"e1e86031-6537-11eb-953a-f7ab92be508d","last_name":"Brückner","orcid":"0000-0001-7205-2975","first_name":"David","full_name":"Brückner, David"},{"id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","last_name":"Tkačik","orcid":"0000-0002-6699-1455","first_name":"Gašper","full_name":"Tkačik, Gašper"}],"date_published":"2026-01-23T00:00:00Z","file_date_updated":"2026-02-24T06:57:44Z","day":"23","article_type":"original","title":"Marr's three levels for embryonic development: Information, dynamical systems, gene networks","date_updated":"2026-02-24T07:00:16Z","ddc":["570"],"OA_place":"publisher","publication":"PRX Life","corr_author":"1","article_number":"017001","_id":"21282","project":[{"_id":"7bfe6a29-9f16-11ee-852c-c0da5e2045d9","name":"Transcription in 4D: the dynamic interplay between chromatin architecture and gene expression in developing pseudo-embryos","grant_number":"101118866"}],"citation":{"apa":"Brückner, D., &#38; Tkačik, G. (2026). Marr’s three levels for embryonic development: Information, dynamical systems, gene networks. <i>PRX Life</i>. American Physical Society. <a href=\"https://doi.org/10.1103/fdcf-dkws\">https://doi.org/10.1103/fdcf-dkws</a>","ieee":"D. Brückner and G. Tkačik, “Marr’s three levels for embryonic development: Information, dynamical systems, gene networks,” <i>PRX Life</i>, vol. 4. American Physical Society, 2026.","short":"D. Brückner, G. Tkačik, PRX Life 4 (2026).","ama":"Brückner D, Tkačik G. Marr’s three levels for embryonic development: Information, dynamical systems, gene networks. <i>PRX Life</i>. 2026;4. doi:<a href=\"https://doi.org/10.1103/fdcf-dkws\">10.1103/fdcf-dkws</a>","ista":"Brückner D, Tkačik G. 2026. Marr’s three levels for embryonic development: Information, dynamical systems, gene networks. PRX Life. 4, 017001.","mla":"Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic Development: Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>, vol. 4, 017001, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/fdcf-dkws\">10.1103/fdcf-dkws</a>.","chicago":"Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic Development: Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/fdcf-dkws\">https://doi.org/10.1103/fdcf-dkws</a>."},"oa":1,"volume":4,"OA_type":"gold","file":[{"content_type":"application/pdf","access_level":"open_access","file_id":"21352","creator":"dernst","relation":"main_file","file_size":1147994,"date_updated":"2026-02-24T06:57:44Z","date_created":"2026-02-24T06:57:44Z","checksum":"99ef02dd741c4536eeefd12d409d5269","file_name":"2026_PRXLife_Brueckner.pdf","success":1}],"department":[{"_id":"GaTk"}],"publisher":"American Physical Society","quality_controlled":"1","article_processing_charge":"Yes","PlanS_conform":"1","external_id":{"arxiv":["2510.24536"]},"year":"2026","acknowledgement":"We thank Edouard Hannezo, Anna Kicheva, Fridtjof Brauns, and all members of the Brückner and Tkačik groups for feedback and inspiring discussions. This work was supported in part by European Research Council ERC-2023-SyG “Dynatrans” Grant No. 101118866 (G.T.). This work was conducted while visiting the Okinawa Institute of Science and Technology (OIST) through the Theoretical Sciences Visiting Program (TSVP); at the Kavli Institute for Theoretical Physics (KITP) Santa Barbara, supported by NSF Grant No. PHY-1748958 and the Gordon and Betty Moore Foundation Grant No. 2919.02; and at Lucullus, Vienna.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2835-8279"]},"date_created":"2026-02-17T08:29:10Z"},{"acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"_id":"21284","OA_place":"repository","ddc":["541"],"corr_author":"1","acknowledgement":"We thank Ben P. Tatman for insightful discussions. This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance Facility and the Lab Support Facility.","year":"2026","date_created":"2026-02-17T10:17:14Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","oa":1,"citation":{"mla":"Becker, Lea Marie, and Paul Schanda. <i>Research Data for “Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21284\">10.15479/AT-ISTA-21284</a>.","chicago":"Becker, Lea Marie, and Paul Schanda. “Research Data for ‘Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21284\">https://doi.org/10.15479/AT-ISTA-21284</a>.","ista":"Becker LM, Schanda P. 2026. Research data for ‘Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21284\">10.15479/AT-ISTA-21284</a>.","short":"L.M. Becker, P. Schanda, (2026).","ama":"Becker LM, Schanda P. Research data for “Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21284\">10.15479/AT-ISTA-21284</a>","ieee":"L. M. Becker and P. Schanda, “Research data for ‘Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.’” Institute of Science and Technology Austria, 2026.","apa":"Becker, L. M., &#38; Schanda, P. (2026). Research data for “Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21284\">https://doi.org/10.15479/AT-ISTA-21284</a>"},"article_processing_charge":"No","OA_type":"free access","license":"https://creativecommons.org/licenses/by-nc/4.0/","department":[{"_id":"GradSch"},{"_id":"PaSc"}],"publisher":"Institute of Science and Technology Austria","file":[{"creator":"lbecker","file_id":"21285","access_level":"open_access","content_type":"application/zip","relation":"main_file","date_created":"2026-02-17T10:11:14Z","checksum":"2d3105f26be578073b88ee1f2ea0bdb1","date_updated":"2026-02-17T10:11:14Z","file_size":36996027,"success":1,"file_name":"Research_data.zip"},{"date_updated":"2026-02-17T10:11:14Z","file_size":1993,"checksum":"e24aebcdb8856cb181cbaa02de020ddb","date_created":"2026-02-17T10:11:14Z","file_name":"README.txt","creator":"lbecker","content_type":"text/plain","access_level":"open_access","file_id":"21286","relation":"table_of_contents"}],"status":"public","month":"2","type":"research_data","abstract":[{"text":"The advantageous characteristics attributed to the 19F nucleus have made it a popular target for NMR once again in recent years. Aside from solution NMR, an increasing number of studies have been conducted applying solid-state magic-angle-spinning NMR to fluorine-labeled samples. Here, the high chemical shift anisotropy and strong dipolar couplings can be utilized to get structural insights into proteins and measure long distances. Despite increasing popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labeled biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F and 13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labeled protein via 19F-detected MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially reduces measurement times of 19F MAS NMR experiments without compromising resolution. Additionally, we report the chemical-shift assignments of all four fluorotryptophan signals in the 12 × 39 kDa large protein using a mutagenesis approach.","lang":"eng"}],"oa_version":"None","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"doi":"10.15479/AT-ISTA-21284","contributor":[{"contributor_type":"researcher","last_name":"Toscano","id":"334a5e40-8747-11f0-b671-ba1f5154b4b4","first_name":"Giorgia"},{"id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471","last_name":"Kapitonova","contributor_type":"researcher","first_name":"Anna"},{"first_name":"Rajkumar","last_name":"Singh","id":"a3089acd-6806-11ee-bacc-f0c7d500ad20","contributor_type":"researcher"},{"last_name":"Guillerm","id":"bb74f472-ae54-11eb-9835-bc9c22fb1183","contributor_type":"researcher","first_name":"Undina"},{"first_name":"Roman","contributor_type":"researcher","last_name":"Lichtenecker"}],"day":"18","date_updated":"2026-02-18T10:12:49Z","title":"Research data for \"Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants\"","has_accepted_license":"1","file_date_updated":"2026-02-17T10:11:14Z","date_published":"2026-02-18T00:00:00Z","author":[{"id":"36336939-eb97-11eb-a6c2-c83f1214ca79","last_name":"Becker","orcid":"0000-0002-6401-5151","full_name":"Becker, Lea Marie","first_name":"Lea Marie"},{"first_name":"Paul","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","last_name":"Schanda"}]},{"month":"02","status":"public","type":"preprint","abstract":[{"lang":"eng","text":"Gene duplication underlies evolutionary innovation, yet many paralogues remain highly similar, raising questions about their functional divergence and physiological relevance. The spliceosomal Sm core protein SNRPB and its mammalian-specific paralogue SNRPN share over 90% sequence identity, but their distinct expression patterns - SNRPB being ubiquitous and SNRPN confined to the brain - suggest specialized functions. Why mammals have two different spliceosomes has remained obscure. Here, we generated isogenic human cell lines expressing ectopically either SNRPB or SNRPN exclusively and found that SNRPN stabilizes transcripts involved in energy metabolism and mitochondrial function, leading to increased mitochondrial abundance and oxygen consumption. Despite similar spliceosomal interactomes, SNRPN more strongly associates with the PRMT5 methylosome complex and exhibits dynamic arginine methylation in its C-terminal region that is sensitive to translation inhibition and amino acid availability. The SNRPN-dependent transcriptome responds to translation inhibition by stabilizing long, intron-rich genes involved in amino acid and energy metabolism. Our findings reveal a nutrient-sensitive, methylation-dependent mechanism that differentiates the two paralogues. This suggests that SNRPN functions as a metabolic-specialized spliceosomal subunit thereby providing tissue-specific adaptation of RNA processing in mammals."}],"_id":"21290","language":[{"iso":"eng"}],"OA_place":"repository","publication":"bioRxiv","doi":"10.64898/2026.02.11.705284","oa_version":"Preprint","publication_status":"submitted","day":"11","year":"2026","acknowledgement":"We thank Oliver Mühlemann and Alex Hofer (University of Bern) for sharing SMG inhibitors\r\nand for their expertise in nonsense-mediated mRNA decay and Maria Hondele for critical\r\nreading of the manuscript draft. We also thank the IMB Genomics Core Facility for assistance\r\nwith library preparation and sequencing, Martin Möckel and the IMB Protein Production Core\r\nFacility for providing enzymes used in this work, Marton Gelleri together with the IMB\r\nMicroscopy Core Facility for support with microscopy and FRAP experiments, Jasmin Cartano\r\nfor proteomics sample processing and the IMB Flow Cytometry Core Facility for support. In\r\naddition, we thank the Imaging Core Facility (IMCF) and the FACS Core Facility at the\r\nBiozentrum, University of Basel, for technical assistance. CIKV acknowledges funding by the\r\nDeutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Individual Grant\r\nProject no. 513744403, Scientific Network Grant Project no. 531902894, GRK2526 “Genevo”\r\n- Project no. 407023052”, GRK2859 (“4R”) - Project no. 491145305, Forschungsinitiative\r\nRheinland-Pfalz (ReALity), the EMBO Young Investigator Program (5795), institutional\r\nfunding from the Institute of Molecular Biology and funds from the Kanton Basel-Stadt and\r\nBasel-Land provided to the Biozentrum of the University Basel. J.H.G.F.G. was part of the\r\n‘Science of Healthy Ageing Research Programme’ (SHARP) initiative funded by RhinelandPalatinate’s Ministry of Science, Education and Culture. PR is funded by the Biozentrum PhD\r\nFellowships Program. MFB received financial support from the intramural High Potentials\r\nGrant program of the University Medical Center Mainz, Forschungsinitiative Rheinland-Pfalz\r\n(ReALity) and Stiftungen zugunsten der Medizinischen Fakultät der LMU Klinikum (26069).\r\nInstruments in the IMB core facilities were supported by funds from the DFG: Laser Scanning\r\nConfocal (Leica Stellaris 8 Falcon, funded by the DFG - Project #497669232), Orbitrap Astral system (funded by the DFG - Project #524805621) and BD LSRFortessa SOPR is funded by\r\nthe DFG - Project #210253511.\r\n","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-02-17T11:35:59Z","date_updated":"2026-02-23T11:03:33Z","title":"The splicing paralogues SNRPB and SNRPN control differential metabolic states.","citation":{"ieee":"F. Polat Haas <i>et al.</i>, “The splicing paralogues SNRPB and SNRPN control differential metabolic states.,” <i>bioRxiv</i>. .","apa":"Polat Haas, F., Villalba Requena, A., Rusina, P., Gopalan, A., Fritz, H., Akhmetkaliyev, A., … Keller Valsecchi, C. I. (n.d.). The splicing paralogues SNRPB and SNRPN control differential metabolic states. <i>bioRxiv</i>. <a href=\"https://doi.org/10.64898/2026.02.11.705284\">https://doi.org/10.64898/2026.02.11.705284</a>","ama":"Polat Haas F, Villalba Requena A, Rusina P, et al. The splicing paralogues SNRPB and SNRPN control differential metabolic states. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.64898/2026.02.11.705284\">10.64898/2026.02.11.705284</a>","short":"F. Polat Haas, A. Villalba Requena, P. Rusina, A. Gopalan, H. Fritz, A. Akhmetkaliyev, F. Ruehle, A. Einsiedel, A. Szczepinska, F. Kielisch, J.-X. Chen, S. Nguyen, T. Schmidlin, S. Hippenmeyer, M.F. Bailicata, C.I. Keller Valsecchi, BioRxiv (n.d.).","ista":"Polat Haas F, Villalba Requena A, Rusina P, Gopalan A, Fritz H, Akhmetkaliyev A, Ruehle F, Einsiedel A, Szczepinska A, Kielisch F, Chen J-X, Nguyen S, Schmidlin T, Hippenmeyer S, Bailicata MF, Keller Valsecchi CI. The splicing paralogues SNRPB and SNRPN control differential metabolic states. bioRxiv, <a href=\"https://doi.org/10.64898/2026.02.11.705284\">10.64898/2026.02.11.705284</a>.","chicago":"Polat Haas, Feyza, Ana Villalba Requena, Polina Rusina, Anusha Gopalan, Hector Fritz, Azamat Akhmetkaliyev, Frank Ruehle, et al. “The Splicing Paralogues SNRPB and SNRPN Control Differential Metabolic States.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.64898/2026.02.11.705284\">https://doi.org/10.64898/2026.02.11.705284</a>.","mla":"Polat Haas, Feyza, et al. “The Splicing Paralogues SNRPB and SNRPN Control Differential Metabolic States.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.64898/2026.02.11.705284\">10.64898/2026.02.11.705284</a>."},"oa":1,"author":[{"first_name":"Feyza","full_name":"Polat Haas, Feyza","last_name":"Polat Haas"},{"orcid":"0000-0002-5615-5277","first_name":"Ana","full_name":"Villalba Requena, Ana","last_name":"Villalba Requena","id":"68cb85a0-39f7-11eb-9559-9aaab4f6a247"},{"full_name":"Rusina, Polina","first_name":"Polina","last_name":"Rusina"},{"last_name":"Gopalan","full_name":"Gopalan, Anusha","first_name":"Anusha"},{"full_name":"Fritz, Hector","first_name":"Hector","last_name":"Fritz"},{"first_name":"Azamat","full_name":"Akhmetkaliyev, Azamat","last_name":"Akhmetkaliyev"},{"last_name":"Ruehle","full_name":"Ruehle, Frank","first_name":"Frank"},{"first_name":"Anna","full_name":"Einsiedel, Anna","last_name":"Einsiedel"},{"last_name":"Szczepinska","full_name":"Szczepinska, Anna","first_name":"Anna"},{"last_name":"Kielisch","first_name":"Fridolin","full_name":"Kielisch, Fridolin"},{"first_name":"Jia-Xuan","full_name":"Chen, Jia-Xuan","last_name":"Chen"},{"last_name":"Nguyen","first_name":"Susanne","full_name":"Nguyen, Susanne"},{"last_name":"Schmidlin","full_name":"Schmidlin, Thierry","first_name":"Thierry"},{"full_name":"Hippenmeyer, Simon","first_name":"Simon","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Bailicata, M. Felicia","first_name":"M. Felicia","last_name":"Bailicata"},{"first_name":"Claudia Isabelle","full_name":"Keller Valsecchi, Claudia Isabelle","last_name":"Keller Valsecchi"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.64898/2026.02.11.705284"}],"department":[{"_id":"SiHi"}],"OA_type":"green","date_published":"2026-02-11T00:00:00Z","article_processing_charge":"No"},{"status":"public","month":"02","abstract":[{"lang":"eng","text":"Depending on the type of flow, the transition to turbulence can take one of two forms: either turbulence arises from a sequence of instabilities or from the spatial proliferation of transiently chaotic domains, a process analogous to directed percolation. The former scenario is commonly referred to as a supercritical transition and frequently encountered in flows destabilized by body forces, whereas the latter subcritical transition is common in shear flows. Both cases are inherently continuous in a sense that the transformation from ordered laminar to fully turbulent fluid motion is only accomplished gradually with flow speed. Here we show that these established transition types do not account for the more general setting of shear flows subject to body forces. The combination of the two continuous scenarios leads to the attenuation of spatial coupling; with increasing forcing amplitude, the transition becomes increasingly sharp and eventually discontinuous. We argue that the suppression of laminar–turbulent coexistence and the approach towards a discontinuous phase transition potentially apply to a broad range of situations including flows subject to, for example, buoyancy, centrifugal or electromagnetic forces."}],"type":"journal_article","language":[{"iso":"eng"}],"arxiv":1,"publication_status":"epub_ahead","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1038/s41567-025-03166-3","day":"17","title":"Discontinuous transition to shear flow turbulence","date_updated":"2026-02-23T11:36:46Z","article_type":"original","has_accepted_license":"1","scopus_import":"1","date_published":"2026-02-17T00:00:00Z","author":[{"orcid":"0000-0002-4843-6853","full_name":"Yang, Bowen","first_name":"Bowen","id":"71b6ff4b-15b2-11ec-abd3-aef6b028cf7e","last_name":"Yang"},{"last_name":"Zhuang","id":"3677B57C-F248-11E8-B48F-1D18A9856A87","full_name":"Zhuang, Yi","first_name":"Yi"},{"id":"66E74FA2-D8BF-11E9-8249-8DE2E5697425","last_name":"Yalniz","first_name":"Gökhan","full_name":"Yalniz, Gökhan","orcid":"0000-0002-8490-9312"},{"full_name":"Vasudevan, Mukund","first_name":"Mukund","last_name":"Vasudevan","id":"3C5A959A-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-7173-4923","first_name":"Elena","full_name":"Marensi, Elena","last_name":"Marensi","id":"0BE7553A-1004-11EA-B805-18983DDC885E"},{"last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","first_name":"Björn","orcid":"0000-0003-2057-2754"}],"_id":"21295","OA_place":"publisher","ddc":["532"],"corr_author":"1","publication":"Nature Physics","acknowledgement":"The work was supported by the Simons Foundation (grant number 662960, to B.H.). Open access funding provided by Institute of Science and Technology (IST Austria).","year":"2026","external_id":{"arxiv":["2311.11474"]},"PlanS_conform":"1","date_created":"2026-02-17T11:38:41Z","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ieee":"B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, and B. Hof, “Discontinuous transition to shear flow turbulence,” <i>Nature Physics</i>. Springer Nature, 2026.","apa":"Yang, B., Zhuang, Y., Yalniz, G., Vasudevan, M., Marensi, E., &#38; Hof, B. (2026). Discontinuous transition to shear flow turbulence. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-025-03166-3\">https://doi.org/10.1038/s41567-025-03166-3</a>","ama":"Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. Discontinuous transition to shear flow turbulence. <i>Nature Physics</i>. 2026. doi:<a href=\"https://doi.org/10.1038/s41567-025-03166-3\">10.1038/s41567-025-03166-3</a>","short":"B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, B. Hof, Nature Physics (2026).","ista":"Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. 2026. Discontinuous transition to shear flow turbulence. Nature Physics.","mla":"Yang, Bowen, et al. “Discontinuous Transition to Shear Flow Turbulence.” <i>Nature Physics</i>, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41567-025-03166-3\">10.1038/s41567-025-03166-3</a>.","chicago":"Yang, Bowen, Yi Zhuang, Gökhan Yalniz, Mukund Vasudevan, Elena Marensi, and Björn Hof. “Discontinuous Transition to Shear Flow Turbulence.” <i>Nature Physics</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41567-025-03166-3\">https://doi.org/10.1038/s41567-025-03166-3</a>."},"project":[{"name":"Revisiting the Turbulence Problem Using Statistical Mechanics","grant_number":"662960","_id":"238598C6-32DE-11EA-91FC-C7463DDC885E"}],"article_processing_charge":"Yes (via OA deal)","quality_controlled":"1","department":[{"_id":"GradSch"},{"_id":"BjHo"}],"publisher":"Springer Nature","OA_type":"hybrid"},{"_id":"21311","ddc":["550"],"OA_place":"publisher","publication":"Earth Systems and Environment","corr_author":"1","PlanS_conform":"1","year":"2026","acknowledgement":"The author would like to thank Fundación Universitaria Los Libertadores (Project ID: ING-40-25) for supporting her in this work. And EALB, would like to thank Universidad Sergio Arboleda (Project ID: IN.BG.086.24.015) for supporting her in this work. Open access funding provided by Institute of Science and Technology (IST Austria). The first author was funded by the Fundacion Universitaria Los Libertadores (Project ID: ING-40-25). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101034413289 awarded to AC. EALB was supported by Universidad Sergio Arboleda (Project ID: IN.BG.086.24.015).","publication_identifier":{"issn":["2509-9426"],"eissn":["2509-9434"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-02-18T07:11:14Z","citation":{"apa":"González, Y., Malagón, N., Benavides, K., Belalcázar, L. C., Lopez-Barrera, E. A., &#38; Casallas Garcia, A. (2026). Spatio-temporal trends of air pollution in six South American cities. <i>Earth Systems and Environment</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s41748-026-01068-9\">https://doi.org/10.1007/s41748-026-01068-9</a>","ieee":"Y. González, N. Malagón, K. Benavides, L. C. Belalcázar, E. A. Lopez-Barrera, and A. Casallas Garcia, “Spatio-temporal trends of air pollution in six South American cities,” <i>Earth Systems and Environment</i>. Springer Nature, 2026.","ama":"González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas Garcia A. Spatio-temporal trends of air pollution in six South American cities. <i>Earth Systems and Environment</i>. 2026. doi:<a href=\"https://doi.org/10.1007/s41748-026-01068-9\">10.1007/s41748-026-01068-9</a>","short":"Y. González, N. Malagón, K. Benavides, L.C. Belalcázar, E.A. Lopez-Barrera, A. Casallas Garcia, Earth Systems and Environment (2026).","ista":"González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas Garcia A. 2026. Spatio-temporal trends of air pollution in six South American cities. Earth Systems and Environment.","chicago":"González, Yuri, Nicolás Malagón, Kevin Benavides, Luis Carlos Belalcázar, Ellie Anne Lopez-Barrera, and Alejandro Casallas Garcia. “Spatio-Temporal Trends of Air Pollution in Six South American Cities.” <i>Earth Systems and Environment</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/s41748-026-01068-9\">https://doi.org/10.1007/s41748-026-01068-9</a>.","mla":"González, Yuri, et al. “Spatio-Temporal Trends of Air Pollution in Six South American Cities.” <i>Earth Systems and Environment</i>, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1007/s41748-026-01068-9\">10.1007/s41748-026-01068-9</a>."},"oa":1,"publisher":"Springer Nature","OA_type":"hybrid","department":[{"_id":"CaMu"}],"quality_controlled":"1","article_processing_charge":"Yes (via OA deal)","month":"02","status":"public","abstract":[{"text":"Air pollution is a critical public health issue worldwide, South America faces unique challenges due to rapid urban growth, industrial expansion, and recurrent biomass burning. Existing studies have largely focused on regional or national scales, overlooking detailed spatio-temporal dynamics in cities. This study provides a comprehensive assessment of air pollution spatio-temporal trends from 2013 to 2023 in six major South American cities: Bogotá, Buenos Aires, Montevideo, Quito, Santiago de Chile, and São Paulo. We evaluated four key pollutants, NO2, O3, PM10, and PM2.5, using in situ monitoring networks complemented with reanalysis (boundary layer and pollution dynamics), and fire detections datasets (biomass burning). A key innovation is the use of a Lagrangian Tracker, which identifies persistent hotspots and transport pathways of pollutants, offering new insights into transboundary pollution. Results show that nearly all cities experienced reductions in particulate matter concentrations, while three of the six cities exhibited rising O3 levels, reflecting complex interactions between emissions, meteorology, and atmospheric chemistry. Santiago de Chile recorded the highest levels of NO2 and PM, strongly influenced by topography and biomass burning in JJA. Bogotá and Quito were notably impacted by regional fire emissions, whereas coastal cities such as Buenos Aires and Montevideo benefited from greater pollutant dispersion but still exceeded the World Health Organization guidelines. By integrating ground-based, satellite, and reanalysis data with advanced trajectory modeling, this research provides detailed spatio-temporal evaluations of air pollution in South America and highlights the urgent need for coordinated regional strategies to reduce health and economic burdens.","lang":"eng"}],"type":"journal_article","language":[{"iso":"eng"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1007/s41748-026-01068-9","oa_version":"Published Version","publication_status":"epub_ahead","day":"17","article_type":"original","date_updated":"2026-02-23T11:57:21Z","title":"Spatio-temporal trends of air pollution in six South American cities","scopus_import":"1","has_accepted_license":"1","author":[{"full_name":"González, Yuri","first_name":"Yuri","last_name":"González"},{"full_name":"Malagón, Nicolás","first_name":"Nicolás","last_name":"Malagón"},{"last_name":"Benavides","first_name":"Kevin","full_name":"Benavides, Kevin"},{"first_name":"Luis Carlos","full_name":"Belalcázar, Luis Carlos","last_name":"Belalcázar"},{"last_name":"Lopez-Barrera","full_name":"Lopez-Barrera, Ellie Anne","first_name":"Ellie Anne"},{"orcid":"0000-0002-1988-5035","first_name":"Alejandro","full_name":"Casallas Garcia, Alejandro","last_name":"Casallas Garcia","id":"92081129-2d75-11ef-a48d-b04dd7a2385a"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1007/s41748-026-01068-9"}],"date_published":"2026-02-17T00:00:00Z"},{"author":[{"first_name":"Anton","full_name":"Bubis, Anton","id":"1f6212b5-f795-11ec-9c0c-de4780302890","last_name":"Bubis"},{"id":"539e1e1a-e604-11ee-a1df-f02b018e5c8c","last_name":"Vigliotti","first_name":"Lucia","full_name":"Vigliotti, Lucia"},{"orcid":"0000-0002-2399-5827","first_name":"Maksym","full_name":"Serbyn, Maksym","last_name":"Serbyn","id":"47809E7E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Higginbotham, Andrew P","first_name":"Andrew P","orcid":"0000-0003-2607-2363","last_name":"Higginbotham","id":"4AD6785A-F248-11E8-B48F-1D18A9856A87"}],"file_date_updated":"2026-02-24T07:23:32Z","date_published":"2026-02-13T00:00:00Z","has_accepted_license":"1","title":"Non-equilibrium plasmon liquid in a Josephson junction chain","date_updated":"2026-02-24T07:25:34Z","article_type":"original","day":"13","oa_version":"Published Version","doi":"10.1126/sciadv.ady7222","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","language":[{"iso":"eng"}],"DOAJ_listed":"1","arxiv":1,"type":"journal_article","abstract":[{"lang":"eng","text":"Equilibrium quantum systems are often described by a gas of weakly interacting normal modes. Bringing such systems far from equilibrium, however, can drastically enhance mode-to-mode interactions. Understanding the resulting liquid is a fundamental question for quantum statistical mechanics and a practical question for engineering driven quantum devices. To tackle this question, we probe the non-equilibrium kinetics of one-dimensional plasmons in a long chain of Josephson junctions. We introduce multimode spectroscopy to controllably study the departure from equilibrium, witnessing the evolution from pairwise coupling between plasma modes at weak driving to dramatic, high-order, cascaded couplings at strong driving. Scaling to many-mode drives, we stimulate interactions between hundreds of modes, resulting in near-continuum internal dynamics. Imaging the resulting non-equilibrium plasmon populations, we then resolve the nonlocal redistribution of energy in the response to a weak perturbation—an explicit verification of the emergence of a strongly interacting, non-equilibrium liquid of plasmons."}],"status":"public","month":"02","intvolume":"        12","publisher":"American Association for the Advancement of Science","OA_type":"gold","file":[{"creator":"dernst","file_id":"21353","content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"8402f322f8f0e858b1d9aac57e306e31","date_created":"2026-02-24T07:23:32Z","date_updated":"2026-02-24T07:23:32Z","file_size":2775975,"success":1,"file_name":"2026_ScienceAdv_Bubis.pdf"}],"department":[{"_id":"MaSe"},{"_id":"AnHi"},{"_id":"GeKa"}],"article_processing_charge":"Yes","quality_controlled":"1","issue":"7","volume":12,"oa":1,"citation":{"chicago":"Bubis, Anton, Lucia Vigliotti, Maksym Serbyn, and Andrew P Higginbotham. “Non-Equilibrium Plasmon Liquid in a Josephson Junction Chain.” <i>Science Advances</i>. American Association for the Advancement of Science, 2026. <a href=\"https://doi.org/10.1126/sciadv.ady7222\">https://doi.org/10.1126/sciadv.ady7222</a>.","mla":"Bubis, Anton, et al. “Non-Equilibrium Plasmon Liquid in a Josephson Junction Chain.” <i>Science Advances</i>, vol. 12, no. 7, eady7222, American Association for the Advancement of Science, 2026, doi:<a href=\"https://doi.org/10.1126/sciadv.ady7222\">10.1126/sciadv.ady7222</a>.","ista":"Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. 2026. Non-equilibrium plasmon liquid in a Josephson junction chain. Science Advances. 12(7), eady7222.","ama":"Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. Non-equilibrium plasmon liquid in a Josephson junction chain. <i>Science Advances</i>. 2026;12(7). doi:<a href=\"https://doi.org/10.1126/sciadv.ady7222\">10.1126/sciadv.ady7222</a>","short":"A. Bubis, L. Vigliotti, M. Serbyn, A.P. Higginbotham, Science Advances 12 (2026).","ieee":"A. Bubis, L. Vigliotti, M. Serbyn, and A. P. Higginbotham, “Non-equilibrium plasmon liquid in a Josephson junction chain,” <i>Science Advances</i>, vol. 12, no. 7. American Association for the Advancement of Science, 2026.","apa":"Bubis, A., Vigliotti, L., Serbyn, M., &#38; Higginbotham, A. P. (2026). Non-equilibrium plasmon liquid in a Josephson junction chain. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.ady7222\">https://doi.org/10.1126/sciadv.ady7222</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2375-2548"]},"date_created":"2026-02-22T20:47:38Z","external_id":{"arxiv":["2504.09721"]},"PlanS_conform":"1","acknowledgement":"We thank V. Vitelli, M. Fruchart, and A. Burshstein for helpful input. We acknowledge technical support from the Nanofabrication Facility and the MIBA machine shop at IST Austria. This research was supported in part by grant NSF PHY-2309135 to the Kavli Institute for Theoretical Physics (KITP), by the Austrian Science Fund (FWF) SFB F86, and by the NOMIS foundation.","year":"2026","corr_author":"1","publication":"Science Advances","ddc":["530"],"OA_place":"publisher","_id":"21340","acknowledged_ssus":[{"_id":"NanoFab"},{"_id":"M-Shop"}],"article_number":"eady7222"},{"publication":"Astronomy & Astrophysics","corr_author":"1","ddc":["520"],"OA_place":"publisher","_id":"21341","article_number":"A165","OA_type":"diamond","department":[{"_id":"JoMa"},{"_id":"GradSch"}],"publisher":"EDP Sciences","file":[{"date_created":"2026-02-24T07:46:47Z","checksum":"6f5849d29ad43bee32f90152f6fc0294","file_size":6531719,"date_updated":"2026-02-24T07:46:47Z","success":1,"file_name":"2026_AstronomyAstrophysics_Kotiwale.pdf","file_id":"21355","access_level":"open_access","content_type":"application/pdf","creator":"dernst","relation":"main_file"}],"quality_controlled":"1","article_processing_charge":"No","project":[{"_id":"bd9b2118-d553-11ed-ba76-db24564edfea","name":"Young galaxies as tracers and agents of cosmic reionization","grant_number":"101076224"}],"citation":{"mla":"Kotiwale, Gauri, et al. “Rapid, out-of-Equilibrium Metal Enrichment Indicated by a Flat Mass-Metallicity Relation at z ∼ 6 from NIRCam Grism Spectroscopy.” <i>Astronomy &#38; Astrophysics</i>, vol. 706, A165, EDP Sciences, 2026, doi:<a href=\"https://doi.org/10.1051/0004-6361/202556597\">10.1051/0004-6361/202556597</a>.","chicago":"Kotiwale, Gauri, Jorryt J Matthee, Daichi Kashino, Aswin P. Vijayan, Alberto Torralba Torregrosa, Claudia Di Cesare, Edoardo Iani, et al. “Rapid, out-of-Equilibrium Metal Enrichment Indicated by a Flat Mass-Metallicity Relation at z ∼ 6 from NIRCam Grism Spectroscopy.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2026. <a href=\"https://doi.org/10.1051/0004-6361/202556597\">https://doi.org/10.1051/0004-6361/202556597</a>.","ista":"Kotiwale G, Matthee JJ, Kashino D, Vijayan AP, Torralba Torregrosa A, Di Cesare C, Iani E, Bordoloi R, Leja J, Maseda MV, Tacchella S, Shivaei I, Heintz KE, Danhaive AL, Mascia S, Kramarenko I, Navarrete B, Mackenzie R, Naidu RP, Sobral D. 2026. Rapid, out-of-equilibrium metal enrichment indicated by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy. Astronomy &#38; Astrophysics. 706, A165.","ama":"Kotiwale G, Matthee JJ, Kashino D, et al. Rapid, out-of-equilibrium metal enrichment indicated by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy. <i>Astronomy &#38; Astrophysics</i>. 2026;706. doi:<a href=\"https://doi.org/10.1051/0004-6361/202556597\">10.1051/0004-6361/202556597</a>","short":"G. Kotiwale, J.J. Matthee, D. Kashino, A.P. Vijayan, A. Torralba Torregrosa, C. Di Cesare, E. Iani, R. Bordoloi, J. Leja, M.V. Maseda, S. Tacchella, I. Shivaei, K.E. Heintz, A.L. Danhaive, S. Mascia, I. Kramarenko, B. Navarrete, R. Mackenzie, R.P. Naidu, D. Sobral, Astronomy &#38; Astrophysics 706 (2026).","apa":"Kotiwale, G., Matthee, J. J., Kashino, D., Vijayan, A. P., Torralba Torregrosa, A., Di Cesare, C., … Sobral, D. (2026). Rapid, out-of-equilibrium metal enrichment indicated by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy. <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/0004-6361/202556597\">https://doi.org/10.1051/0004-6361/202556597</a>","ieee":"G. Kotiwale <i>et al.</i>, “Rapid, out-of-equilibrium metal enrichment indicated by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy,” <i>Astronomy &#38; Astrophysics</i>, vol. 706. EDP Sciences, 2026."},"volume":706,"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"date_created":"2026-02-22T23:01:35Z","PlanS_conform":"1","external_id":{"arxiv":["2510.19959"]},"year":"2026","acknowledgement":"We thank the anonymous referee for the insightful comments that helped improving this paper. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Associations of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations were taken under programmes # 1243, # 1933 and # 3516. Funded by the European Union (ERC, AGENTS, 101076224). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. GK acknowledges support from the Foundation MERAC. APV acknowledge support from the Sussex Astronomy Centre STFC Consolidated Grant (ST/X001040/1).","doi":"10.1051/0004-6361/202556597","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa_version":"Published Version","publication_status":"published","arxiv":1,"DOAJ_listed":"1","language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"text":"We aim to characterise the mass-metallicity relation (MZR) and the 3D correlation between the stellar mass, metallicity, and star formation rate (SFR) known as the fundamental metallicity relation (FMR) for galaxies at 5 < z < 7. Using ∼800 [O III] selected galaxies from deep NIRCam grism surveys, we present our stacked measurements of direct-Te metallicities, which we used to test recent strong-line metallicity calibrations. Our measured direct-Te metallicities (0.1–0.2 Z⊙ for M★ ≈ 5 × 107 − 9 M⊙, respectively) match recent JWST/NIRSpec-based results. However, there are significant inconsistencies between observations and hydrodynamical simulations. We observe a flatter MZR slope than the SPHINX20 and FLARES simulations, which cannot be attributed to selection effects. With simple models, we show that the effect of an [O III] flux-limited sample on the observed shape of the MZR is strongly dependent on the FMR. If the FMR is similar to the one in the local Universe, the intrinsic high-redshift MZR should be even flatter than is observed. In turn, a 3D relation where SFR correlates positively with metallicity at fixed mass would imply an intrinsically steeper MZR. Our measurements indicate that metallicity variations at fixed mass show little dependence on the SFR, suggesting a flat intrinsic MZR. This could indicate that the low-mass galaxies at these redshifts are out of equilibrium and that metal enrichment occurs rapidly in low-mass galaxies. However, being limited by our stacking analysis, we are yet to probe the scatter in the MZR and its dependence on SFR. Large carefully selected samples of galaxies with robust metallicity measurements can put tight constraints on the high-redshift FMR and help us to understand the interplay between gas flows, star formation, and feedback in early galaxies.","lang":"eng"}],"month":"02","status":"public","intvolume":"       706","author":[{"first_name":"Gauri","full_name":"Kotiwale, Gauri","id":"1438afc8-1ff6-11ee-9fa6-cd4a75d66875","last_name":"Kotiwale"},{"first_name":"Jorryt J","full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"last_name":"Kashino","first_name":"Daichi","full_name":"Kashino, Daichi"},{"last_name":"Vijayan","first_name":"Aswin P.","full_name":"Vijayan, Aswin P."},{"orcid":"0000-0001-5586-6950","full_name":"Torralba Torregrosa, Alberto","first_name":"Alberto","id":"018f0249-0e87-11f0-b167-cbce08fbd541","last_name":"Torralba Torregrosa"},{"last_name":"Di Cesare","id":"2d002343-372f-11ef-98ec-a164d20427cb","full_name":"Di Cesare, Claudia","first_name":"Claudia"},{"last_name":"Iani","id":"4053390a-6b68-11ef-9828-a3b8adef8d0a","orcid":"0000-0001-8386-3546","full_name":"Iani, Edoardo","first_name":"Edoardo"},{"last_name":"Bordoloi","first_name":"Rongmon","full_name":"Bordoloi, Rongmon"},{"first_name":"Joel","full_name":"Leja, Joel","last_name":"Leja"},{"full_name":"Maseda, Michael V.","first_name":"Michael V.","last_name":"Maseda"},{"last_name":"Tacchella","first_name":"Sandro","full_name":"Tacchella, Sandro"},{"last_name":"Shivaei","full_name":"Shivaei, Irene","first_name":"Irene"},{"full_name":"Heintz, Kasper E.","first_name":"Kasper E.","last_name":"Heintz"},{"full_name":"Danhaive, A. Lola","first_name":"A. Lola","last_name":"Danhaive"},{"last_name":"Mascia","id":"edaf889c-c7cd-11ef-ab1b-bb28c431bd29","full_name":"Mascia, Sara","first_name":"Sara"},{"first_name":"Ivan","full_name":"Kramarenko, Ivan","orcid":"0000-0001-5346-6048","id":"9a9394cb-3200-11ee-973b-f5ba2a8b16e4","last_name":"Kramarenko"},{"id":"aa14a535-50c9-11ef-b52e-e0c373d10148","last_name":"Navarrete","full_name":"Navarrete, Benjamín","first_name":"Benjamín"},{"last_name":"Mackenzie","first_name":"Ruari","full_name":"Mackenzie, Ruari"},{"full_name":"Naidu, Rohan P.","first_name":"Rohan P.","last_name":"Naidu"},{"last_name":"Sobral","first_name":"David","full_name":"Sobral, David"}],"date_published":"2026-02-01T00:00:00Z","file_date_updated":"2026-02-24T07:46:47Z","scopus_import":"1","has_accepted_license":"1","article_type":"original","title":"Rapid, out-of-equilibrium metal enrichment indicated by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy","date_updated":"2026-02-24T07:49:42Z","day":"01"},{"project":[{"_id":"bd9b2118-d553-11ed-ba76-db24564edfea","grant_number":"101076224","name":"Young galaxies as tracers and agents of cosmic reionization"}],"oa":1,"volume":9,"citation":{"ista":"Naidu RP, Oesch PA, Brammer G, Weibel A, Li Y, Matthee JJ, Chisholm J, Pollock CL, Heintz KE, Johnson BD, Shen X, Hviding RE, Leja J, Tacchella S, Ganguly A, Witten C, Atek H, Belli S, Bose S, Bouwens R, Dayal P, Decarli R, De Graaff A, Fudamoto Y, Giovinazzo E, Greene JE, Illingworth G, Inoue AK, Kane SG, Labbe I, Leonova E, Marques-Chaves R, Meyer RA, Nelson EJ, Roberts-Borsani G, Schaerer D, Simcoe RA, Stefanon M, Sugahara Y, Toft S, Van Der Wel A, Van Dokkum P, Walter F, Watson D, Weaver JR, Whitaker KE. 2026. A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST. The Open Journal of Astrophysics. 9.","chicago":"Naidu, Rohan P., Pascal A. Oesch, Gabriel Brammer, Andrea Weibel, Yijia Li, Jorryt J Matthee, John Chisholm, et al. “A Cosmic Miracle: A Remarkably Luminous Galaxy at Zspec = 14.44 Confirmed with JWST.” <i>The Open Journal of Astrophysics</i>. Maynooth Academic Publishing, 2026. <a href=\"https://doi.org/10.33232/001c.156033\">https://doi.org/10.33232/001c.156033</a>.","mla":"Naidu, Rohan P., et al. “A Cosmic Miracle: A Remarkably Luminous Galaxy at Zspec = 14.44 Confirmed with JWST.” <i>The Open Journal of Astrophysics</i>, vol. 9, Maynooth Academic Publishing, 2026, doi:<a href=\"https://doi.org/10.33232/001c.156033\">10.33232/001c.156033</a>.","apa":"Naidu, R. P., Oesch, P. A., Brammer, G., Weibel, A., Li, Y., Matthee, J. J., … Whitaker, K. E. (2026). A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST. <i>The Open Journal of Astrophysics</i>. Maynooth Academic Publishing. <a href=\"https://doi.org/10.33232/001c.156033\">https://doi.org/10.33232/001c.156033</a>","ieee":"R. P. Naidu <i>et al.</i>, “A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST,” <i>The Open Journal of Astrophysics</i>, vol. 9. Maynooth Academic Publishing, 2026.","short":"R.P. Naidu, P.A. Oesch, G. Brammer, A. Weibel, Y. Li, J.J. Matthee, J. Chisholm, C.L. Pollock, K.E. Heintz, B.D. Johnson, X. Shen, R.E. Hviding, J. Leja, S. Tacchella, A. Ganguly, C. Witten, H. Atek, S. Belli, S. Bose, R. Bouwens, P. Dayal, R. Decarli, A. De Graaff, Y. Fudamoto, E. Giovinazzo, J.E. Greene, G. Illingworth, A.K. Inoue, S.G. Kane, I. Labbe, E. Leonova, R. Marques-Chaves, R.A. Meyer, E.J. Nelson, G. Roberts-Borsani, D. Schaerer, R.A. Simcoe, M. Stefanon, Y. Sugahara, S. Toft, A. Van Der Wel, P. Van Dokkum, F. Walter, D. Watson, J.R. Weaver, K.E. Whitaker, The Open Journal of Astrophysics 9 (2026).","ama":"Naidu RP, Oesch PA, Brammer G, et al. A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST. <i>The Open Journal of Astrophysics</i>. 2026;9. doi:<a href=\"https://doi.org/10.33232/001c.156033\">10.33232/001c.156033</a>"},"OA_type":"diamond","department":[{"_id":"JoMa"}],"publisher":"Maynooth Academic Publishing","article_processing_charge":"No","quality_controlled":"1","external_id":{"arxiv":["2505.11263"]},"PlanS_conform":"1","acknowledgement":"We thank the two anonymous referees for their insightful comments that have strengthened this work. “Mirage or Miracle” is but the latest link in a long chain of surveys that have built COSMOS into a premier extragalactic legacy field. We are thankful to all the teams who have contributed to this legacy, particularly those mentioned in §3 for leading recent JWST programs whose imaging\r\nwe have incorporated in our analysis. We are grateful to Vasily Belokurov for help in compiling the Milky Way reference sample featured in Fig 8. We thank Danielle Berg for sharing a highly complete, highly decimalized NUV vacuum line list. We are grateful to our program’s NIRSpec reviewer, Dan Coe, and program coordinator, Allison Vick, for valuable input on our MSA design. We acknowledge illuminating conversations with Risa Wechsler and Chao-Lin Kuo about early reionization. RPN thanks Neil Pappalardo and Jane Pappalardo for their generous support of the MIT Pappalardo Fellowships in Physics, and for their enthusiasm and encouragement for seeking galaxies at the highest redshifts. RPN acknowledges funding from JWST program GO5224. Support for this work was provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss National Science Foundation (SNSF) through project grant 200020 207349. Funded by the European Union (ERC, AGENTS, 101076224 and HEAVYMETAL, 101071865). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of\r\nthe European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant DNRF140. This work has also been supported by JSPS KAKENHI Grant Number 23H00131. HA acknowledges support from CNES, focused on the JWST mission, and the Programme National Cosmology and Galaxies (PNCG)\r\nof CNRS/INSU with INP and IN2P3, co-funded by CEA and CNES. HA is supported by the French National Research Agency (ANR) under the project FIRSTGAL, grant number ANR-24-CE31-0838. SB is supported by the UK Research and Innovation (UKRI) Future Leaders Fellowship [grant number MR/V023381/1]. R.D. acknowledges support from the INAF GO 2022\r\ngrant “The birth of the giants: JWST sheds light on the build-up of quasars at cosmic dawn” and by the PRIN MUR “2022935STW”, RFF M4.C2.1.1, CUP J53D23001570006 and C53D23000950006. Computations supporting this paper were run on MIT’s Engaging cluster. This publication made use of the NASA Astrophysical Data System for bibliographic information. Some of the data products presented herein were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN), which is funded by the Danish National Research Foundation under grant DNRF140. Software used in developing this work includes: matplotlib (Hunter 2007), jupyter (Kluyver et al. 2016), IPython (P´erez & Granger 2007), numpy (Oliphant 2015), scipy (Virtanen et al. 2020), TOPCAT (Taylor 2005), and Astropy (Astropy Collaboration et al. 2013).This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space\r\nTelescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with program # 5224.","year":"2026","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2565-6120"]},"date_created":"2026-02-22T23:01:35Z","ddc":["520"],"OA_place":"publisher","publication":"The Open Journal of Astrophysics","_id":"21342","scopus_import":"1","has_accepted_license":"1","main_file_link":[{"open_access":"1","url":"https:/​/​doi.org/​10.33232/​001c.156033"}],"author":[{"first_name":"Rohan P.","full_name":"Naidu, Rohan P.","last_name":"Naidu"},{"last_name":"Oesch","full_name":"Oesch, Pascal A.","first_name":"Pascal A."},{"full_name":"Brammer, Gabriel","first_name":"Gabriel","last_name":"Brammer"},{"last_name":"Weibel","full_name":"Weibel, Andrea","first_name":"Andrea"},{"last_name":"Li","first_name":"Yijia","full_name":"Li, Yijia"},{"orcid":"0000-0003-2871-127X","full_name":"Matthee, Jorryt J","first_name":"Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720","last_name":"Matthee"},{"full_name":"Chisholm, John","first_name":"John","last_name":"Chisholm"},{"last_name":"Pollock","first_name":"Clara L.","full_name":"Pollock, Clara L."},{"last_name":"Heintz","first_name":"Kasper E.","full_name":"Heintz, Kasper E."},{"last_name":"Johnson","first_name":"Benjamin D.","full_name":"Johnson, Benjamin D."},{"full_name":"Shen, Xuejian","first_name":"Xuejian","last_name":"Shen"},{"last_name":"Hviding","first_name":"Raphael E.","full_name":"Hviding, Raphael E."},{"last_name":"Leja","first_name":"Joel","full_name":"Leja, Joel"},{"last_name":"Tacchella","full_name":"Tacchella, Sandro","first_name":"Sandro"},{"full_name":"Ganguly, Arpita","first_name":"Arpita","last_name":"Ganguly"},{"last_name":"Witten","full_name":"Witten, Callum","first_name":"Callum"},{"last_name":"Atek","full_name":"Atek, Hakim","first_name":"Hakim"},{"first_name":"Sirio","full_name":"Belli, Sirio","last_name":"Belli"},{"first_name":"Sownak","full_name":"Bose, Sownak","last_name":"Bose"},{"first_name":"Rychard","full_name":"Bouwens, Rychard","last_name":"Bouwens"},{"full_name":"Dayal, Pratika","first_name":"Pratika","last_name":"Dayal"},{"last_name":"Decarli","first_name":"Roberto","full_name":"Decarli, Roberto"},{"first_name":"Anna","full_name":"De Graaff, Anna","last_name":"De Graaff"},{"last_name":"Fudamoto","full_name":"Fudamoto, Yoshinobu","first_name":"Yoshinobu"},{"last_name":"Giovinazzo","first_name":"Emma","full_name":"Giovinazzo, Emma"},{"first_name":"Jenny E.","full_name":"Greene, Jenny E.","last_name":"Greene"},{"full_name":"Illingworth, Garth","first_name":"Garth","last_name":"Illingworth"},{"last_name":"Inoue","first_name":"Akio K.","full_name":"Inoue, Akio K."},{"last_name":"Kane","first_name":"Sarah G.","full_name":"Kane, Sarah G."},{"full_name":"Labbe, Ivo","first_name":"Ivo","last_name":"Labbe"},{"last_name":"Leonova","full_name":"Leonova, Ecaterina","first_name":"Ecaterina"},{"last_name":"Marques-Chaves","full_name":"Marques-Chaves, Rui","first_name":"Rui"},{"last_name":"Meyer","first_name":"Romain A.","full_name":"Meyer, Romain A."},{"full_name":"Nelson, Erica J.","first_name":"Erica J.","last_name":"Nelson"},{"last_name":"Roberts-Borsani","full_name":"Roberts-Borsani, Guido","first_name":"Guido"},{"last_name":"Schaerer","full_name":"Schaerer, Daniel","first_name":"Daniel"},{"full_name":"Simcoe, Robert A.","first_name":"Robert A.","last_name":"Simcoe"},{"last_name":"Stefanon","full_name":"Stefanon, Mauro","first_name":"Mauro"},{"full_name":"Sugahara, Yuma","first_name":"Yuma","last_name":"Sugahara"},{"last_name":"Toft","full_name":"Toft, Sune","first_name":"Sune"},{"full_name":"Van Der Wel, Arjen","first_name":"Arjen","last_name":"Van Der Wel"},{"last_name":"Van Dokkum","full_name":"Van Dokkum, Pieter","first_name":"Pieter"},{"first_name":"Fabian","full_name":"Walter, Fabian","last_name":"Walter"},{"last_name":"Watson","first_name":"Darach","full_name":"Watson, Darach"},{"last_name":"Weaver","first_name":"John R.","full_name":"Weaver, John R."},{"first_name":"Katherine E.","full_name":"Whitaker, Katherine E.","last_name":"Whitaker"}],"date_published":"2026-01-30T00:00:00Z","day":"30","title":"A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST","date_updated":"2026-02-24T07:37:17Z","article_type":"original","language":[{"iso":"eng"}],"arxiv":1,"oa_version":"Published Version","doi":"10.33232/001c.156033","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","status":"public","month":"01","intvolume":"         9","type":"journal_article","abstract":[{"text":"JWST has revealed a stunning population of bright galaxies at surprisingly early epochs, z > 10,\r\nwhere few such sources were expected. Here we present the most distant example of this class yet – MoM-z14, a luminous (MUV = −20.2) source in the COSMOS legacy field at zspec = 14.44+0.02−0.02 that expands the observational frontier to a mere 280 million years after the Big Bang. The redshift is confirmed with NIRSpec/prism spectroscopy through a sharp Lyman-α break and ≈ 3σ detections of five rest-UV emission lines. The number density of bright zspec ≈ 14 − 15 sources implied by our “Mirage or Miracle” survey spanning ≈ 350 arcmin2 is > 100× larger (182+329 −105×) than pre-JWST consensus models. The high EWs of UV lines (≈15−35˚A) signal a rising star-formation history, with a ≈10× increase in the last 5 Myr (SFR5Myr/SFR50Myr = 9.9 +3.0 −5.8). The source is extremely compact (circularized re = 74+15\r\n−12 pc), and yet elongated (b/a = 0.25+0.11−0.06), suggesting an AGN is not the dominant source of UV light. The steep UV slope (β = −2.5 +0.2 −0.2) implies negligible dust attenuation\r\nand a young stellar population. The absence of a strong damping wing provides tentative evidence that the immediate surroundings of MoM-z14 may be partially ionized at a redshift where virtually every reionization model predicts a ≈ 100% neutral fraction. The nitrogen emission and highly supersolar [N/C]> 1 hint at an abundance pattern similar to local globular clusters that may have once hosted luminous supermassive stars. Since this abundance pattern is also common among the most ancient stars born in the Milky Way, we may be directly witnessing the formation of such stars in dense clusters, connecting galaxy evolution across the entire sweep of cosmic time. ","lang":"eng"}]},{"project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","call_identifier":"H2020"}],"oa":1,"citation":{"ista":"Bustos D, Garcia D, Rojas NY, Lopez-Barrera EA, Peña-Rincon C, Casallas Garcia A. 2026. Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia. Earth Systems and Environment.","chicago":"Bustos, Daniela, Diana Garcia, Nestor Y. Rojas, Ellie A. Lopez-Barrera, Carlos Peña-Rincon, and Alejandro Casallas Garcia. “Ozone Trends and Mortality Risk: The Growing Need for Machine Learning Predictions in Bogotá, Colombia.” <i>Earth Systems and Environment</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/s41748-026-01052-3\">https://doi.org/10.1007/s41748-026-01052-3</a>.","mla":"Bustos, Daniela, et al. “Ozone Trends and Mortality Risk: The Growing Need for Machine Learning Predictions in Bogotá, Colombia.” <i>Earth Systems and Environment</i>, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1007/s41748-026-01052-3\">10.1007/s41748-026-01052-3</a>.","ieee":"D. Bustos, D. Garcia, N. Y. Rojas, E. A. Lopez-Barrera, C. Peña-Rincon, and A. Casallas Garcia, “Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia,” <i>Earth Systems and Environment</i>. Springer Nature, 2026.","apa":"Bustos, D., Garcia, D., Rojas, N. Y., Lopez-Barrera, E. A., Peña-Rincon, C., &#38; Casallas Garcia, A. (2026). Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia. <i>Earth Systems and Environment</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s41748-026-01052-3\">https://doi.org/10.1007/s41748-026-01052-3</a>","ama":"Bustos D, Garcia D, Rojas NY, Lopez-Barrera EA, Peña-Rincon C, Casallas Garcia A. Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia. <i>Earth Systems and Environment</i>. 2026. doi:<a href=\"https://doi.org/10.1007/s41748-026-01052-3\">10.1007/s41748-026-01052-3</a>","short":"D. Bustos, D. Garcia, N.Y. Rojas, E.A. Lopez-Barrera, C. Peña-Rincon, A. Casallas Garcia, Earth Systems and Environment (2026)."},"OA_type":"hybrid","publisher":"Springer Nature","department":[{"_id":"CaMu"}],"article_processing_charge":"Yes (via OA deal)","quality_controlled":"1","PlanS_conform":"1","acknowledgement":"EAL-B and CP-R received support from Sergio Arboleda University through project No. IN.BG.086.24.014. AC acknowledges support by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034413. We thank two anonymous reviewers for thein insightful comments that largely improve the manuscript. Open access funding provided by Institute of Science and Technology (IST Austria). This work was funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034413. The work also received funding from Sergio Arboleda University through project No. IN.BG.086.24.014.","year":"2026","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2509-9434"],"issn":["2509-9426"]},"date_created":"2026-02-23T08:26:51Z","ddc":["550"],"OA_place":"publisher","corr_author":"1","publication":"Earth Systems and Environment","_id":"21344","ec_funded":1,"has_accepted_license":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1007/s41748-026-01052-3"}],"author":[{"first_name":"Daniela","full_name":"Bustos, Daniela","last_name":"Bustos"},{"last_name":"Garcia","full_name":"Garcia, Diana","first_name":"Diana"},{"full_name":"Rojas, Nestor Y.","first_name":"Nestor Y.","last_name":"Rojas"},{"first_name":"Ellie A.","full_name":"Lopez-Barrera, Ellie A.","last_name":"Lopez-Barrera"},{"full_name":"Peña-Rincon, Carlos","first_name":"Carlos","last_name":"Peña-Rincon"},{"orcid":"0000-0002-1988-5035","full_name":"Casallas Garcia, Alejandro","first_name":"Alejandro","last_name":"Casallas Garcia","id":"92081129-2d75-11ef-a48d-b04dd7a2385a"}],"date_published":"2026-02-20T00:00:00Z","day":"20","title":"Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia","date_updated":"2026-02-24T08:02:58Z","article_type":"original","language":[{"iso":"eng"}],"oa_version":"Published Version","doi":"10.1007/s41748-026-01052-3","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"epub_ahead","status":"public","month":"02","type":"journal_article","abstract":[{"lang":"eng","text":"Tropospheric ozone has the potential to become an increasingly pressing public health issue in Bogotá, Colombia, due to rising concentrations across the city driven by complex interactions among emissions, meteorology, and urban structure. This study presents a comprehensive spatiotemporal analysis of ozone levels from 2013 to 2023 and assesses the associated health burden using mortality data from the same period. Results reveal a consistent upward trend in ozone concentrations, particularly in northern, western, and southern localities, with seasonal peaks linked to biomass burning and photochemical conditions. Mortality analysis, based on the Global Exposure Mortality Model, estimates that 18.3% of all deaths among individuals aged 25 and older are attributable to long-term ozone exposure. The highest burdens are found in densely populated and socioeconomically vulnerable areas such as Kennedy, Suba, and Ciudad Bolívar, with the elderly being the most affected. Building on these findings, we developed a machine learning prediction model for ozone using a convolutional merge with a long-short term memory network architecture trained on air quality and meteorological variables. The model demonstrated strong predictive performance (mean Rho=0.86, RMSE=3.5 μg/m3) across monitoring stations (17 with at least 35000 data points), supporting its potential application in real-time early warning systems across Bogotá. This integrated approach highlights the importance of localized air quality management, combining epidemiological assessment with predictive modeling. The findings underscore the urgency of implementing region-specific mitigation strategies and improving monitoring infrastructure to reduce health risks from ozone exposure in Bogotá’s rapidly growing urban environment."}]},{"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"_id":"21360","OA_place":"repository","ddc":["570","575","583"],"corr_author":"1","year":"2026","acknowledgement":"I would like to acknowledge the Austrian Academy of Sciences (ÖAW) and European\r\nResearch Executive Agency (REA) for funding my research (DOC ÖAW Fellowship\r\n26130, Horizon Europe BOLERO Project 101060393). ","date_created":"2026-02-27T09:08:14Z","alternative_title":["ISTA Thesis"],"publication_identifier":{"issn":["2663-337X"]},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","citation":{"short":"S. Riegler, Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species, Institute of Science and Technology Austria, 2026.","ama":"Riegler S. Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21360\">10.15479/AT-ISTA-21360</a>","ieee":"S. Riegler, “Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species,” Institute of Science and Technology Austria, 2026.","apa":"Riegler, S. (2026). <i>Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21360\">https://doi.org/10.15479/AT-ISTA-21360</a>","mla":"Riegler, Stefan. <i>Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21360\">10.15479/AT-ISTA-21360</a>.","chicago":"Riegler, Stefan. “Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21360\">https://doi.org/10.15479/AT-ISTA-21360</a>.","ista":"Riegler S. 2026. 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Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21363\">10.15479/AT-ISTA-21363</a>.","chicago":"Riegler, Stefan. “Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21363\">https://doi.org/10.15479/AT-ISTA-21363</a>."},"file_date_updated":"2026-02-27T09:13:11Z","article_processing_charge":"No","date_published":"2026-02-27T00:00:00Z","file":[{"creator":"sriegler","content_type":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","access_level":"closed","file_id":"21364","relation":"main_file","file_size":63749444,"date_updated":"2026-02-27T09:11:33Z","date_created":"2026-02-27T09:11:33Z","checksum":"de9145fa166a28c588b5184a2d3d4fee","file_name":"SupplementaryTables.xlsx","embargo_to":"open_access","embargo":"2027-02-27"},{"relation":"main_file","creator":"sriegler","file_id":"21365","access_level":"closed","content_type":"text/plain","file_name":"ReadMe.txt","embargo_to":"open_access","embargo":"2027-02-27","date_created":"2026-02-27T09:13:11Z","checksum":"ce1f163551c96cee45943a8ea29720b6","date_updated":"2026-02-27T09:13:11Z","file_size":124}],"department":[{"_id":"GradSch"},{"_id":"EvBe"}],"publisher":"Institute of Science and Technology Austria","author":[{"orcid":"0000-0003-3413-1343","full_name":"Riegler, Stefan","first_name":"Stefan","id":"FF6018E0-D806-11E9-8E43-0B14E6697425","last_name":"Riegler"}],"year":"2026","contributor":[{"orcid":"0000-0002-8510-9739","first_name":"Eva","last_name":"Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","contributor_type":"supervisor"}],"day":"27","title":"Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea  species","date_updated":"2026-03-09T12:20:56Z","date_created":"2026-02-27T09:18:41Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","ddc":["575"],"oa_version":"None","corr_author":"1","doi":"10.15479/AT-ISTA-21363","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","short":"CC BY-SA (4.0)","image":"/images/cc_by_sa.png"},"status":"public","month":"02","_id":"21363","type":"research_data","abstract":[{"lang":"eng","text":"The data contains information on coffee differential gene expression as well as co-expression and trait correlations in two separate experiments. First, contrasting nitrogen supply, second, intra- and interspecific grafting."}],"related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"21360"}]}},{"date_updated":"2026-03-02T09:36:48Z","title":"Structural defects in amyloid-β fibrils drive secondary nucleation","article_type":"original","day":"20","author":[{"last_name":"Hu","full_name":"Hu, Jing","first_name":"Jing"},{"last_name":"Scheidt","first_name":"Tom","full_name":"Scheidt, Tom"},{"last_name":"Thacker","full_name":"Thacker, Dev","first_name":"Dev"},{"last_name":"Axell","first_name":"Emil","full_name":"Axell, Emil"},{"last_name":"Stemme","first_name":"Elin","full_name":"Stemme, Elin"},{"first_name":"Urszula","full_name":"Łapińska, Urszula","last_name":"Łapińska"},{"last_name":"Wennmalm","full_name":"Wennmalm, Stefan","first_name":"Stefan"},{"full_name":"Meisl, Georg","first_name":"Georg","last_name":"Meisl"},{"last_name":"Curk","id":"031eff0d-d481-11ee-8508-cd12a7a86e5b","orcid":"0000-0001-6160-9766","first_name":"Samo","full_name":"Curk, Samo"},{"first_name":"Maria","full_name":"Andreasen, Maria","last_name":"Andreasen"},{"last_name":"Vendruscolo","first_name":"Michele","full_name":"Vendruscolo, Michele"},{"full_name":"Arosio, Paolo","first_name":"Paolo","last_name":"Arosio"},{"last_name":"Šarić","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela","first_name":"Anđela"},{"full_name":"Schmit, Jeremy D.","first_name":"Jeremy D.","last_name":"Schmit"},{"first_name":"Tuomas P.J.","full_name":"Knowles, Tuomas P.J.","last_name":"Knowles"},{"full_name":"Sparr, Emma","first_name":"Emma","last_name":"Sparr"},{"full_name":"Linse, Sara","first_name":"Sara","last_name":"Linse"},{"last_name":"Michaels","first_name":"Thomas C.T.","full_name":"Michaels, Thomas C.T."},{"last_name":"Dear","full_name":"Dear, Alexander J.","first_name":"Alexander J."}],"file_date_updated":"2026-03-02T09:34:18Z","date_published":"2026-02-20T00:00:00Z","scopus_import":"1","ec_funded":1,"has_accepted_license":"1","abstract":[{"lang":"eng","text":"Formation of new amyloid fibrils and oligomers from monomeric protein on the surfaces of existing fibrils is an important driver of many disorders such as Alzheimer’s and Parkinson’s diseases. The structural basis of this secondary nucleation process, however, is poorly understood. Here, we ask whether secondary nucleation sites are found predominantly at rare growth defects: irregularities in the fibril core structure incorporated during their original assembly. We first demonstrate using the specific inhibitor of secondary nucleation, Brichos, that secondary nucleation sites on Alzheimer’s disease-associated fibrils composed of Aβ40 and Aβ42 peptides are rare compared to the number of protein molecules they contain. We then grow Aβ40 fibrils under conditions designed to eliminate most growth defects while leaving the regular fibril morphology unchanged, and confirm the latter using cryo-electron microscopy. We measure both the ability of these annealed fibrils to promote secondary nucleation and the stoichiometry of their secondary nucleation sites, finding that both are greatly reduced as predicted. Re-analysis of published data for other proteins suggests that fibril growth defects may also drive secondary nucleation generally across most amyloids. These findings could unlock structure-based drug design of therapeutics that aim to halt amyloid disorders by inhibiting secondary nucleation sites."}],"type":"journal_article","status":"public","month":"02","intvolume":"        17","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1038/s41467-026-69377-1","publication_status":"published","language":[{"iso":"eng"}],"DOAJ_listed":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2041-1723"]},"date_created":"2026-03-01T23:01:38Z","external_id":{"pmid":["41708600"]},"PlanS_conform":"1","pmid":1,"acknowledgement":"This work was supported by the Swedish Research Council (2019-02397 to E.S., 2015-00143 to S.L., and 2022-06641 to S.L. and E.S.), and the GenerationNano project, the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 945378 (S.L. co-PI). We acknowledge support from the Wellcome Trust (T.P.J.K.), the Cambridge Centre for Misfolding Diseases (T.P.J.K.), the BBSRC (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the ERC PhysProt (agreement n 337969) (T.S., T.P.J.K., S.L.), ETC StG “NEPA” (A.Š. and S.C.), the Royal Society (S.C., A.S.), the ERASMUS Programme (T.S.), and The Danish Council for Independent Research ∣ Natural Sciences (FNU-11-113326) (M.A.). This work was also funded by the Novo Nordisk Foundation (#NNF19OC0054635 to S.L.), ETH Zürich (T.C.T.M.), and the Swiss National Science Foundation (grant no 219703 to A.J.D. and T.C.T.M.). We acknowledge the use of the nano-Characterisation and nano-Manufacturing Research Equipment (nCHREM) facility for access to microscopy instrumentation. We are grateful to the late Professor Sir Christopher Dobson for invaluable conversations regarding the microfluidic diffusional sizing experiments. We are also grateful to Quentin A. E. Peter and Thomas Müller for their guidance on microfluidic device design. The cuvette-filled icon in Fig. 3d is by Servier [https://smart.servier.com/]. It is licensed under CC-BY 3.0 Unported [https://creativecommons.org/licenses/by/3.0/]. The authors would like to acknowledge Umeå Centre for Electron Microscopy (UCEM) for technical assistance and access to electron microscopy. Support was provided by SciLifeLab national Cryo-EM Unit at Umeå University.","year":"2026","OA_type":"gold","file":[{"success":1,"file_name":"2026_NatureComm_Hu.pdf","date_created":"2026-03-02T09:34:18Z","checksum":"fa2b55b3a0d8978de7d2d061c7ad8779","file_size":4821073,"date_updated":"2026-03-02T09:34:18Z","relation":"main_file","file_id":"21377","access_level":"open_access","content_type":"application/pdf","creator":"dernst"}],"publisher":"Springer Nature","department":[{"_id":"AnSa"}],"article_processing_charge":"Yes","quality_controlled":"1","project":[{"_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","call_identifier":"H2020","grant_number":"802960","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines"}],"volume":17,"oa":1,"citation":{"mla":"Hu, Jing, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary Nucleation.” <i>Nature Communications</i>, vol. 17, 1933, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-026-69377-1\">10.1038/s41467-026-69377-1</a>.","chicago":"Hu, Jing, Tom Scheidt, Dev Thacker, Emil Axell, Elin Stemme, Urszula Łapińska, Stefan Wennmalm, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary Nucleation.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-026-69377-1\">https://doi.org/10.1038/s41467-026-69377-1</a>.","ista":"Hu J, Scheidt T, Thacker D, Axell E, Stemme E, Łapińska U, Wennmalm S, Meisl G, Curk S, Andreasen M, Vendruscolo M, Arosio P, Šarić A, Schmit JD, Knowles TPJ, Sparr E, Linse S, Michaels TCT, Dear AJ. 2026. Structural defects in amyloid-β fibrils drive secondary nucleation. Nature Communications. 17, 1933.","short":"J. Hu, T. Scheidt, D. Thacker, E. Axell, E. Stemme, U. Łapińska, S. Wennmalm, G. Meisl, S. Curk, M. Andreasen, M. Vendruscolo, P. Arosio, A. Šarić, J.D. Schmit, T.P.J. Knowles, E. Sparr, S. Linse, T.C.T. Michaels, A.J. Dear, Nature Communications 17 (2026).","ama":"Hu J, Scheidt T, Thacker D, et al. Structural defects in amyloid-β fibrils drive secondary nucleation. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-026-69377-1\">10.1038/s41467-026-69377-1</a>","apa":"Hu, J., Scheidt, T., Thacker, D., Axell, E., Stemme, E., Łapińska, U., … Dear, A. J. (2026). Structural defects in amyloid-β fibrils drive secondary nucleation. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-026-69377-1\">https://doi.org/10.1038/s41467-026-69377-1</a>","ieee":"J. Hu <i>et al.</i>, “Structural defects in amyloid-β fibrils drive secondary nucleation,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026."},"_id":"21369","article_number":"1933","publication":"Nature Communications","ddc":["570"],"OA_place":"publisher"},{"external_id":{"pmid":["41712710"]},"pmid":1,"acknowledgement":"The author acknowledges the support from the European Union (European Research Council, AGENTS, 101076224).","year":"2026","publication_identifier":{"eissn":["1095-9203"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-03-01T23:01:39Z","project":[{"name":"Young galaxies as tracers and agents of cosmic reionization","grant_number":"101076224","_id":"bd9b2118-d553-11ed-ba76-db24564edfea"}],"issue":"6787","volume":391,"citation":{"ista":"Matthee JJ. 2026. Black holes disguised as little red dots. Science. 391(6787), 767–768.","mla":"Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” <i>Science</i>, vol. 391, no. 6787, AAAS, 2026, pp. 767–68, doi:<a href=\"https://doi.org/10.1126/science.adz8603\">10.1126/science.adz8603</a>.","chicago":"Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” <i>Science</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/science.adz8603\">https://doi.org/10.1126/science.adz8603</a>.","apa":"Matthee, J. J. (2026). Black holes disguised as little red dots. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adz8603\">https://doi.org/10.1126/science.adz8603</a>","ieee":"J. J. Matthee, “Black holes disguised as little red dots,” <i>Science</i>, vol. 391, no. 6787. AAAS, pp. 767–768, 2026.","ama":"Matthee JJ. Black holes disguised as little red dots. <i>Science</i>. 2026;391(6787):767-768. doi:<a href=\"https://doi.org/10.1126/science.adz8603\">10.1126/science.adz8603</a>","short":"J.J. Matthee, Science 391 (2026) 767–768."},"OA_type":"closed access","page":"767-768","publisher":"AAAS","department":[{"_id":"JoMa"}],"article_processing_charge":"No","quality_controlled":"1","_id":"21371","corr_author":"1","publication":"Science","day":"19","title":"Black holes disguised as little red dots","date_updated":"2026-03-02T09:15:45Z","article_type":"comment","scopus_import":"1","author":[{"last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720","orcid":"0000-0003-2871-127X","full_name":"Matthee, Jorryt J","first_name":"Jorryt J"}],"date_published":"2026-02-19T00:00:00Z","status":"public","month":"02","intvolume":"       391","type":"journal_article","abstract":[{"text":"There may be a newly identified early phase of supermassive black hole growth","lang":"eng"}],"language":[{"iso":"eng"}],"oa_version":"None","doi":"10.1126/science.adz8603","publication_status":"published"},{"day":"06","date_updated":"2026-03-02T09:27:26Z","title":"Phenomenological model of decaying Bose polarons","article_type":"letter_note","has_accepted_license":"1","ec_funded":1,"scopus_import":"1","file_date_updated":"2026-03-02T09:24:44Z","date_published":"2026-02-06T00:00:00Z","author":[{"full_name":"Al Hyder, Ragheed","first_name":"Ragheed","id":"d1c405be-ae15-11ed-8510-ccf53278162e","last_name":"Al Hyder"},{"last_name":"Bruun","full_name":"Bruun, G. M.","first_name":"G. M."},{"last_name":"Pohl","full_name":"Pohl, T.","first_name":"T."},{"last_name":"Lemeshko","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802","first_name":"Mikhail","full_name":"Lemeshko, Mikhail"},{"id":"37D278BC-F248-11E8-B48F-1D18A9856A87","last_name":"Volosniev","orcid":"0000-0003-0393-5525","full_name":"Volosniev, Artem","first_name":"Artem"}],"intvolume":"         8","status":"public","month":"02","abstract":[{"lang":"eng","text":"Cold atom experiments show that a mobile impurity particle immersed in a weakly interacting Bose-Einstein condensate forms a well-defined quasiparticle (Bose polaron) for weak to moderate impurity-boson interaction strengths, whereas a significant line broadening is consistently observed for strong interactions. Motivated by this, we introduce a phenomenological theory based on the assumption that the most relevant states are characterized by the impurity correlated with at most one boson, since they have the largest overlap with the uncorrelated states to which the most common experimental probes couple. These experimentally relevant states can, however, decay to lower energy states characterized by correlations involving multiple bosons, and we model this using a minimal variational wave function combined with a complex impurity-boson interaction strength. We first motivate this approach by comparing to a more elaborate theory that includes correlations with up to two bosons. Our phenomenological model is shown to recover the main results of two recent experiments probing both the spectral and the nonequilibrium properties of the Bose polaron. Our work offers an intuitive framework for analyzing experimental data and highlights the importance of understanding the complicated problem of the Bose polaron decay in a many-body setting."}],"type":"journal_article","language":[{"iso":"eng"}],"DOAJ_listed":"1","arxiv":1,"publication_status":"published","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1103/16dk-5dgx","acknowledgement":"We thank Georgios Koutentakis, Frédéric Chevy, Hussam Al Daas, and Richard Schmidt for fruitful discussions; Jan Arlt for sharing their experimental data and many fruitful discussions; and Christoph Eigen for sharing their experimental data and inspiring discussions. R.A., T.P., and G.M.B. have been supported in part by the Danish National Research Foundation through the Center of Excellence “CCQ” (Grant Agreement No. DNRF156) and the Independent Research Fund Denmark–Natural Sciences via Grant No. DFF-8021-00233B. R.A., A.G.V., and M.L. acknowledge support by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). R.A. received funding from the Austrian Academy of Science ÖAW Grant No. PR1029OEAW03.","year":"2026","external_id":{"arxiv":["2507.04143"]},"PlanS_conform":"1","date_created":"2026-03-01T23:01:39Z","publication_identifier":{"issn":["2643-1564"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"volume":8,"citation":{"ista":"Al Hyder R, Bruun GM, Pohl T, Lemeshko M, Volosniev A. 2026. Phenomenological model of decaying Bose polarons. Physical Review Research. 8, L012034.","mla":"Al Hyder, Ragheed, et al. “Phenomenological Model of Decaying Bose Polarons.” <i>Physical Review Research</i>, vol. 8, L012034, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/16dk-5dgx\">10.1103/16dk-5dgx</a>.","chicago":"Al Hyder, Ragheed, G. M. Bruun, T. Pohl, Mikhail Lemeshko, and Artem Volosniev. “Phenomenological Model of Decaying Bose Polarons.” <i>Physical Review Research</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/16dk-5dgx\">https://doi.org/10.1103/16dk-5dgx</a>.","apa":"Al Hyder, R., Bruun, G. M., Pohl, T., Lemeshko, M., &#38; Volosniev, A. (2026). Phenomenological model of decaying Bose polarons. <i>Physical Review Research</i>. American Physical Society. <a href=\"https://doi.org/10.1103/16dk-5dgx\">https://doi.org/10.1103/16dk-5dgx</a>","ieee":"R. Al Hyder, G. M. Bruun, T. Pohl, M. Lemeshko, and A. Volosniev, “Phenomenological model of decaying Bose polarons,” <i>Physical Review Research</i>, vol. 8. American Physical Society, 2026.","ama":"Al Hyder R, Bruun GM, Pohl T, Lemeshko M, Volosniev A. Phenomenological model of decaying Bose polarons. <i>Physical Review Research</i>. 2026;8. doi:<a href=\"https://doi.org/10.1103/16dk-5dgx\">10.1103/16dk-5dgx</a>","short":"R. Al Hyder, G.M. Bruun, T. Pohl, M. Lemeshko, A. Volosniev, Physical Review Research 8 (2026)."},"project":[{"_id":"2688CF98-B435-11E9-9278-68D0E5697425","name":"Angulon: physics and applications of a new quasiparticle","call_identifier":"H2020","grant_number":"801770"},{"grant_number":"12078","name":"Polarons in Lead Halide Perovskites","_id":"8fa7db46-16d5-11f0-9cad-917600954daf"}],"article_processing_charge":"No","quality_controlled":"1","publisher":"American Physical Society","OA_type":"gold","file":[{"creator":"dernst","file_id":"21376","content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"172720f1f0c5c9d06a282e52023a0030","date_created":"2026-03-02T09:24:44Z","file_size":16789781,"date_updated":"2026-03-02T09:24:44Z","success":1,"file_name":"2026_JPhysPhotonics_Volpe.pdf"}],"department":[{"_id":"MiLe"}],"article_number":"L012034","_id":"21373","OA_place":"publisher","ddc":["530"],"corr_author":"1","publication":"Physical Review Research"},{"date_published":"2026-02-13T00:00:00Z","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2511.22526","open_access":"1"}],"author":[{"last_name":"Antić","full_name":"Antić, Todor","first_name":"Todor"},{"first_name":"Aleksa","full_name":"Džuklevski, Aleksa","last_name":"Džuklevski"},{"full_name":"Fiala, Jiří","first_name":"Jiří","last_name":"Fiala"},{"last_name":"Kratochvíl","first_name":"Jan","full_name":"Kratochvíl, Jan"},{"last_name":"Liotta","first_name":"Giuseppe","full_name":"Liotta, Giuseppe"},{"full_name":"Saghafian, Morteza","first_name":"Morteza","id":"f86f7148-b140-11ec-9577-95435b8df824","last_name":"Saghafian"},{"last_name":"Saumell","full_name":"Saumell, Maria","first_name":"Maria"},{"full_name":"Zink, Johannes","first_name":"Johannes","last_name":"Zink"}],"scopus_import":"1","title":"Edge-constrained Hamiltonian paths on a point set","date_updated":"2026-03-02T08:49:20Z","day":"13","publication_status":"published","oa_version":"Preprint","doi":"10.1007/978-3-032-17801-5_39","language":[{"iso":"eng"}],"arxiv":1,"type":"conference","abstract":[{"text":"Let . S be a set of distinct points in general position in the\r\nEuclidean plane. A plane Hamiltonian path on . S is a crossing-free geometric path such that every point of .S is a vertex of the path. It is\r\nknown that, if. S is sufficiently large, there exist three edge-disjoint plane\r\nHamiltonian paths on . S. In this paper we study an edge-constrained\r\nversion of the problem of finding Hamiltonian paths on a point set. We\r\nfirst consider the problem of finding a single plane Hamiltonian path . π\r\nwith endpoints .s, t ∈ S and constraints given by a segment . ab, where\r\n.a, b ∈ S. We consider the following scenarios: (i) .ab ∈ π; (ii) .ab π. We\r\ncharacterize those quintuples . S, a, b, s, t for which . π exists. Secondly,\r\nwe consider the problem of finding two plane Hamiltonian paths . π1, π2\r\non a set . S with constraints given by a segment . ab, where .a, b ∈ S. We\r\nconsider the following scenarios: (i) .π1 and .π2 share no edges and .ab is\r\nan edge of . π1; (ii) .π1 and .π2 share no edges and none of them includes\r\n.ab as an edge; (iii) both .π1 and .π2 include .ab as an edge and share no\r\nother edges. In all cases, we characterize those triples . S, a, b for which\r\n.π1 and .π2 exist.","lang":"eng"}],"intvolume":"     16448","status":"public","month":"02","article_processing_charge":"No","quality_controlled":"1","OA_type":"green","publisher":"Springer Nature","department":[{"_id":"HeEd"}],"page":"532-546","volume":16448,"oa":1,"citation":{"ista":"Antić T, Džuklevski A, Fiala J, Kratochvíl J, Liotta G, Saghafian M, Saumell M, Zink J. 2026. Edge-constrained Hamiltonian paths on a point set. 51st International Conference on Current Trends in Theory and Practice of Computer Science. SOFSEM: Conference on Current Trends in Theory and Practice of Computer Science, LNCS, vol. 16448, 532–546.","mla":"Antić, Todor, et al. “Edge-Constrained Hamiltonian Paths on a Point Set.” <i>51st International Conference on Current Trends in Theory and Practice of Computer Science</i>, vol. 16448, Springer Nature, 2026, pp. 532–46, doi:<a href=\"https://doi.org/10.1007/978-3-032-17801-5_39\">10.1007/978-3-032-17801-5_39</a>.","chicago":"Antić, Todor, Aleksa Džuklevski, Jiří Fiala, Jan Kratochvíl, Giuseppe Liotta, Morteza Saghafian, Maria Saumell, and Johannes Zink. “Edge-Constrained Hamiltonian Paths on a Point Set.” In <i>51st International Conference on Current Trends in Theory and Practice of Computer Science</i>, 16448:532–46. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-3-032-17801-5_39\">https://doi.org/10.1007/978-3-032-17801-5_39</a>.","apa":"Antić, T., Džuklevski, A., Fiala, J., Kratochvíl, J., Liotta, G., Saghafian, M., … Zink, J. (2026). Edge-constrained Hamiltonian paths on a point set. In <i>51st International Conference on Current Trends in Theory and Practice of Computer Science</i> (Vol. 16448, pp. 532–546). Krakow, Poland: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-032-17801-5_39\">https://doi.org/10.1007/978-3-032-17801-5_39</a>","ieee":"T. Antić <i>et al.</i>, “Edge-constrained Hamiltonian paths on a point set,” in <i>51st International Conference on Current Trends in Theory and Practice of Computer Science</i>, Krakow, Poland, 2026, vol. 16448, pp. 532–546.","short":"T. Antić, A. Džuklevski, J. Fiala, J. Kratochvíl, G. Liotta, M. Saghafian, M. Saumell, J. Zink, in:, 51st International Conference on Current Trends in Theory and Practice of Computer Science, Springer Nature, 2026, pp. 532–546.","ama":"Antić T, Džuklevski A, Fiala J, et al. Edge-constrained Hamiltonian paths on a point set. In: <i>51st International Conference on Current Trends in Theory and Practice of Computer Science</i>. Vol 16448. Springer Nature; 2026:532-546. doi:<a href=\"https://doi.org/10.1007/978-3-032-17801-5_39\">10.1007/978-3-032-17801-5_39</a>"},"alternative_title":["LNCS"],"date_created":"2026-03-01T23:01:40Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1611-3349"],"isbn":["9783032178008"],"issn":["0302-9743"]},"acknowledgement":"We thank the organizers of the HOMONOLO 2024 workshop in Nová Louka, Czech Republic, for the fruitful atmosphere where the research on this project was initiated.\r\n\r\nT. Antić, A. Džuklevski, J. Kratochvíl and M. Saumell received funding from GAČR grant 23–04949X, T.A and A.Dž were additionally supported by GAUK grant SVV–2025–260822. G. Liotta was supported in part by MUR of Italy, PRIN Project no. 2022TS4Y3N – EXPAND and PON Project ARS01_00540. J. Fiala was in part supported by GAČR grant 25-16847S.","year":"2026","external_id":{"arxiv":["2511.22526"]},"conference":{"end_date":"2026-02-13","location":"Krakow, Poland","name":"SOFSEM: Conference on Current Trends in Theory and Practice of Computer Science","start_date":"2026-02-09"},"publication":"51st International Conference on Current Trends in Theory and Practice of Computer Science","OA_place":"repository","_id":"21374"},{"publication":"Nature Metabolism","OA_place":"publisher","ddc":["570"],"_id":"21378","quality_controlled":"1","article_processing_charge":"Yes (in subscription journal)","file":[{"relation":"main_file","content_type":"application/pdf","access_level":"open_access","file_id":"21392","creator":"dernst","file_name":"2026_NatureMetab_AmrapaliVishwanath.pdf","success":1,"date_updated":"2026-03-02T15:21:27Z","file_size":5326608,"date_created":"2026-03-02T15:21:27Z","checksum":"365932a599d05bc9ce8a57204e7a1465"}],"page":"467-488","OA_type":"hybrid","publisher":"Springer Nature","department":[{"_id":"TiVo"}],"citation":{"apa":"Amrapali Vishwanath, A., Comyn, T., Mira, R. G., Brossier, C., Pascual-Caro, C., Faour, M., … de Juan-Sanz, J. (2026). Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species. <i>Nature Metabolism</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42255-026-01451-w\">https://doi.org/10.1038/s42255-026-01451-w</a>","ieee":"A. Amrapali Vishwanath <i>et al.</i>, “Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species,” <i>Nature Metabolism</i>, vol. 8, no. 2. Springer Nature, pp. 467–488, 2026.","ama":"Amrapali Vishwanath A, Comyn T, Mira RG, et al. Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species. <i>Nature Metabolism</i>. 2026;8(2):467-488. doi:<a href=\"https://doi.org/10.1038/s42255-026-01451-w\">10.1038/s42255-026-01451-w</a>","short":"A. Amrapali Vishwanath, T. Comyn, R.G. Mira, C. Brossier, C. Pascual-Caro, M. Faour, K. Boumendil, C. Chintaluri, C. Ramon-Duaso, R. Fan, K. Ghosh, H. Farrants, J.-P. Berwick, R. Sivakumar, M. Lopez-Manzaneda, E.R. Schreiter, T. Preat, T.P. Vogels, V. Rangaraju, A. Busquets-Garcia, P.-Y. Plaçais, A. Pavlowsky, J. de Juan-Sanz, Nature Metabolism 8 (2026) 467–488.","ista":"Amrapali Vishwanath A, Comyn T, Mira RG, Brossier C, Pascual-Caro C, Faour M, Boumendil K, Chintaluri C, Ramon-Duaso C, Fan R, Ghosh K, Farrants H, Berwick J-P, Sivakumar R, Lopez-Manzaneda M, Schreiter ER, Preat T, Vogels TP, Rangaraju V, Busquets-Garcia A, Plaçais P-Y, Pavlowsky A, de Juan-Sanz J. 2026. Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species. Nature Metabolism. 8(2), 467–488.","mla":"Amrapali Vishwanath, Anjali, et al. “Mitochondrial Ca2+ Efflux Controls Neuronal Metabolism and Long-Term Memory across Species.” <i>Nature Metabolism</i>, vol. 8, no. 2, Springer Nature, 2026, pp. 467–88, doi:<a href=\"https://doi.org/10.1038/s42255-026-01451-w\">10.1038/s42255-026-01451-w</a>.","chicago":"Amrapali Vishwanath, Anjali, Typhaine Comyn, Rodrigo G. Mira, Claire Brossier, Carlos Pascual-Caro, Maya Faour, Kahina Boumendil, et al. “Mitochondrial Ca2+ Efflux Controls Neuronal Metabolism and Long-Term Memory across Species.” <i>Nature Metabolism</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s42255-026-01451-w\">https://doi.org/10.1038/s42255-026-01451-w</a>."},"volume":8,"oa":1,"issue":"2","project":[{"_id":"c084a126-5a5b-11eb-8a69-d75314a70a87","grant_number":"214316/Z/18/Z","name":"What’s in a memory? Spatiotemporal dynamics in strongly coupled recurrent neuronal networks."}],"date_created":"2026-03-02T10:04:49Z","publication_identifier":{"eissn":["2522-5812"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2026","acknowledgement":"We thank all members of the laboratory of J.d.J.-S. for insightful discussions and comments. We thank S. Perez for technical assistance. This work was made possible by the Paris Brain Institute Diane Barriere Chair in Synaptic Bioenergetics awarded to J.d.J.-S., who is also supported by an ERC Starting Grant (SynaptoEnergy, European Research Council; ERC-StG-852873), 2019 ATIP-Avenir Grant (CNRS, Inserm), a Big Brain Theory Grant (ICM Foundation) and a Kavli Exploratory Award (Kavli Foundation). This work was also supported by an ERC Advanced Grant (EnergyMeMo; ERC-AdG-741550) to T.P. and grants from the Agence Nationale de la Recherche to P.Y.P. (ANR-20-CE92-0047-01), T.P. (ANR-23-CE16-0029-01), A.P. and J.d.J.-S. (ANR-22-CE16-0020) and J.d.J.-S. (ANR-24-CE16-0221). T.P., P.Y.P. and J.d.J.-S. are permanent CNRS researchers. A.P. is a permanent ESPCI associate professor. T.C. was funded by the French Ministry of Research and the Fondation pour la Recherche Médicale. V.R. was funded by the Max Planck Society, the Chan Zuckerberg Initiative DAF, an advised fund of the Silicon Valley Community Foundation grant number 2024-349543 and the NIH Director’s New Innovator Award (DP2 MH140148). A.B.-G. and C.R.-D. received funding from an ERC Starting Grant (HighMemory; ERC-StG-948217), the Ministry of Economy and Competitiveness (PID2021-122795OB-I00) and the Departament d’Economia i Coneixement de la Generalitat de Catalunya (SGR 00022). T.P.V. was funded by the Wellcome Trust and a Royal Society Sir Henry Dale Research Fellowship (WT100000) and a Wellcome Trust Senior Research Fellowship (214316/Z/18/Z). K.G. was supported by the DIM C-BRAINS, funded by the Conseil Régional d’Ile-de-France. The contributions of H.F. and E.R.S. were supported by the Howard Hughes Medical Institute. The PHENO-ICMice animal Core at ICM is supported by two ‘Investissements d’avenir’ (ANR-10- IAIHU-06 and ANR-11-INBS-0011-NeurATRIS) and the Fondation pour la Recherche Médicale.","pmid":1,"PlanS_conform":"1","external_id":{"pmid":["41673453"]},"publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1038/s42255-026-01451-w","oa_version":"Published Version","language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"lang":"eng","text":"From insects to mammals, essential brain functions, such as forming long-term memories (LTMs), increase metabolic activity in stimulated neurons to meet the energetic demand associated with brain activation. However, while impairing neuronal metabolism limits brain performance, whether expanding the metabolic capacity of neurons boosts brain function remains poorly understood. Here, we show that LTM formation of flies and mice can be enhanced by increasing mitochondrial metabolism in central memory circuits. By knocking down the mitochondrial Ca2+ exporter Letm1, we favour Ca2+ retention in the mitochondrial matrix of neurons due to reduction of mitochondrial H+/Ca2+ exchange. The resulting increase in mitochondrial Ca2+ over-activates mitochondrial metabolism in neurons of central memory circuits, leading to improved LTM storage in training paradigms in which wild-type counterparts of both species fail to remember. Our findings unveil an evolutionarily conserved mechanism that controls mitochondrial metabolism in neurons and indicate its involvement in shaping higher brain functions, such as LTM."}],"intvolume":"         8","month":"02","status":"public","date_published":"2026-02-11T00:00:00Z","file_date_updated":"2026-03-02T15:21:27Z","author":[{"full_name":"Amrapali Vishwanath, Anjali","first_name":"Anjali","last_name":"Amrapali Vishwanath"},{"first_name":"Typhaine","full_name":"Comyn, Typhaine","last_name":"Comyn"},{"full_name":"Mira, Rodrigo G.","first_name":"Rodrigo G.","last_name":"Mira"},{"full_name":"Brossier, Claire","first_name":"Claire","last_name":"Brossier"},{"last_name":"Pascual-Caro","first_name":"Carlos","full_name":"Pascual-Caro, Carlos"},{"last_name":"Faour","first_name":"Maya","full_name":"Faour, Maya"},{"last_name":"Boumendil","full_name":"Boumendil, Kahina","first_name":"Kahina"},{"id":"BA06AFEE-A4BA-11EA-AE5C-14673DDC885E","last_name":"Chintaluri","full_name":"Chintaluri, Chaitanya","first_name":"Chaitanya","orcid":"0000-0003-4252-1608"},{"last_name":"Ramon-Duaso","first_name":"Carla","full_name":"Ramon-Duaso, Carla"},{"full_name":"Fan, Ruolin","first_name":"Ruolin","last_name":"Fan"},{"last_name":"Ghosh","full_name":"Ghosh, Kishalay","first_name":"Kishalay"},{"full_name":"Farrants, Helen","first_name":"Helen","last_name":"Farrants"},{"first_name":"Jean-Paul","full_name":"Berwick, Jean-Paul","last_name":"Berwick"},{"first_name":"Riya","full_name":"Sivakumar, Riya","last_name":"Sivakumar"},{"last_name":"Lopez-Manzaneda","full_name":"Lopez-Manzaneda, Mario","first_name":"Mario"},{"last_name":"Schreiter","first_name":"Eric R.","full_name":"Schreiter, Eric R."},{"first_name":"Thomas","full_name":"Preat, Thomas","last_name":"Preat"},{"first_name":"Tim P","full_name":"Vogels, Tim P","orcid":"0000-0003-3295-6181","last_name":"Vogels","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425"},{"full_name":"Rangaraju, Vidhya","first_name":"Vidhya","last_name":"Rangaraju"},{"full_name":"Busquets-Garcia, Arnau","first_name":"Arnau","last_name":"Busquets-Garcia"},{"first_name":"Pierre-Yves","full_name":"Plaçais, Pierre-Yves","last_name":"Plaçais"},{"last_name":"Pavlowsky","full_name":"Pavlowsky, Alice","first_name":"Alice"},{"last_name":"de Juan-Sanz","full_name":"de Juan-Sanz, Jaime","first_name":"Jaime"}],"has_accepted_license":"1","scopus_import":"1","article_type":"original","date_updated":"2026-03-02T15:23:10Z","title":"Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species","day":"11"}]