[{"OA_place":"publisher","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","abstract":[{"text":"The widespread adoption of apps like Whatsapp and Signal has translated into billions of people all around the world communicating on a regular basis by making use of services that offer end-to-end encryption and even provide security guarantees when a user's device is compromised.\r\n\r\nThis was made possible by the introduction of the Double Ratchet Algorithm~\\cite{double_ratchet}, which was designed for a setting where communication takes place between two parties.\r\nHowever, in practice, many apps offer the possibility of creating groups.\r\nThe protocols they use to secure communication are inefficient for large group which has the undesireable consequence that the aforementioned apps have established limits on the group size of roughly 1000 users.\r\nThis has motivated the introduction of the Messaging Layer Security (MLS) standard~\\cite{rfc9420} by the IETF which is based on a primitive called Continuous Group Key Agreement (CGKA)~\\cite{C:ACDT20}.\r\n\r\nThis primitive allows a group of users to maintain a shared secret key that is frequently rotated by the group members in order to change group membership, achieve forward secrecy (FS) and post compromise security (PCS).\r\nMost protocols are based on binary trees where the nodes are associated to a pair formed by public key and a secret key.\r\nEach leaf corresponds to one of the group members and a user knows the secret keys associated to nodes along the path from their leaf to the root.\r\nWhen a user wants to update their key material they have to change $ \\log(N) $ many keys.\r\nThis requires uploading $ \\log(N) $ many ciphertexts to communicate the new keys to the rest of the group members in a way that respects the tree structure.\r\n\r\nIn this thesis we study how much communication between group members is required in order to add and remove users from a group as well as in order to provide PCS when we consider CGKAs built using standard cryptographic primitives like pseudo-random functions and public-key encryption. Furthermore, we also consider the case of MLS and provide the first lower bound showing that its communication complexity is much worse than previously believed, i.e., it is very far from $ \\log(N) $.\r\nFinally, we also propose a variant of MLS which provably achieves the same security properties with a much lower communication cost.","lang":"eng"}],"year":"2026","corr_author":"1","status":"public","title":"Towards efficient secure group messaging","has_accepted_license":"1","publication_status":"published","file":[{"date_created":"2026-08-13T09:39:00Z","access_level":"open_access","creator":"mcuetono","content_type":"application/pdf","date_updated":"2026-08-19T11:36:46Z","file_size":1390255,"file_id":"22702","file_name":"2026_CuetoNoval_Miguel_Thesis.pdf","checksum":"d61beeb9a250a04396c2c61bbd0783aa","relation":"main_file"},{"content_type":"application/zip","creator":"mcuetono","date_created":"2026-08-13T09:39:01Z","access_level":"closed","date_updated":"2026-08-14T10:26:06Z","file_size":9923509,"file_name":"2026_CuetoNoval_Miguel_Thesis.zip","file_id":"22703","checksum":"4d6def422cc93a108faf5e5defc0f807","relation":"source_file"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)"},"_id":"22664","citation":{"apa":"Cueto Noval, M. (2026). Towards efficient secure group messaging. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22664","ama":"Cueto Noval M. Towards efficient secure group messaging. 2026. doi:10.15479/AT-ISTA-22664","ieee":"M. Cueto Noval, “Towards efficient secure group messaging,” Institute of Science and Technology Austria, 2026.","short":"M. Cueto Noval, Towards Efficient Secure Group Messaging, Institute of Science and Technology Austria, 2026.","ista":"Cueto Noval M. 2026. Towards efficient secure group messaging. Institute of Science and Technology Austria.","mla":"Cueto Noval, Miguel. Towards Efficient Secure Group Messaging. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22664.","chicago":"Cueto Noval, Miguel. “Towards Efficient Secure Group Messaging.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22664."},"day":"10","alternative_title":["ISTA Thesis"],"publication_identifier":{"isbn":[" 978-3-99078-087-9"],"issn":["2663-337X"]},"date_published":"2026-08-10T00:00:00Z","doi":"10.15479/AT-ISTA-22664","doi_confirm":"1","month":"08","type":"dissertation","page":"187","related_material":{"record":[{"status":"public","id":"21262","relation":"part_of_dissertation"},{"status":"public","id":"14691","relation":"part_of_dissertation"},{"id":"18702","relation":"part_of_dissertation","status":"public"}]},"date_updated":"2026-10-16T10:14:40Z","degree_awarded":"PhD","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_created":"2026-08-10T10:18:35Z","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","ddc":["000"],"file_date_updated":"2026-08-19T11:36:46Z","supervisor":[{"full_name":"Pietrzak, Krzysztof Z","last_name":"Pietrzak","orcid":"0000-0002-9139-1654","first_name":"Krzysztof Z","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87"}],"oa":1,"department":[{"_id":"GradSch"},{"_id":"KrPi"}],"article_processing_charge":"No","author":[{"id":"ffc563a3-f6e0-11ea-865d-e3cce03d17cc","first_name":"Miguel","orcid":"0000-0002-2505-4246","last_name":"Cueto Noval","full_name":"Cueto Noval, Miguel"}],"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-22664"},{"project":[{"_id":"92099302-16d5-11f0-9cad-f9a785f54fbd","name":"Trustworthy Deep Learning Theory: Private Over-Parameterized Models and Robust LLMs"},{"grant_number":"101161364","_id":"911e6d1f-16d5-11f0-9cad-c5c68c6a1cdf","name":"Inference in High Dimensions: Light-speed Algorithms and Information Limits"},{"_id":"74caaef7-b034-11f1-8f2d-e0e993bb422e","name":"Bilateral Artificial Intelligence (Mondelli)","grant_number":"COE12"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-22857","language":[{"iso":"eng"}],"oa":1,"department":[{"_id":"GradSch"},{"_id":"MaMo"}],"article_processing_charge":"No","author":[{"last_name":"Bombari","full_name":"Bombari, Simone","id":"ca726dda-de17-11ea-bc14-f9da834f63aa","first_name":"Simone"}],"acknowledged_ssus":[{"_id":"ScienComp"}],"supervisor":[{"orcid":"0000-0002-3242-7020","first_name":"Marco","id":"27EB676C-8706-11E9-9510-7717E6697425","full_name":"Mondelli, Marco","last_name":"Mondelli"}],"file_date_updated":"2026-09-10T10:03:48Z","ddc":["519"],"oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","degree_awarded":"PhD","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_created":"2026-09-08T13:40:08Z","related_material":{"record":[{"status":"public","id":"12537","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"21324"},{"relation":"part_of_dissertation","id":"22894","status":"public"},{"relation":"part_of_dissertation","id":"19627","status":"public"},{"id":"12859","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"18973","relation":"part_of_dissertation"},{"id":"18972","relation":"part_of_dissertation","status":"public"}]},"date_updated":"2026-10-16T10:42:36Z","type":"dissertation","page":"446","month":"09","doi":"10.15479/AT-ISTA-22857","date_published":"2026-09-08T00:00:00Z","doi_confirm":"1","keyword":["machine learning","high-dimensional statistics","deep learning theory","privacy","memorization","robustness"],"publication_identifier":{"isbn":["978-3-99078-091-6"],"issn":["2663-337X"]},"researchdata_availability":"no","_id":"22857","day":"08","citation":{"ista":"Bombari S. 2026. Trustworthy machine learning in high dimensions. Institute of Science and Technology Austria.","short":"S. Bombari, Trustworthy Machine Learning in High Dimensions, Institute of Science and Technology Austria, 2026.","chicago":"Bombari, Simone. “Trustworthy Machine Learning in High Dimensions.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22857.","mla":"Bombari, Simone. Trustworthy Machine Learning in High Dimensions. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22857.","apa":"Bombari, S. (2026). Trustworthy machine learning in high dimensions. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22857","ieee":"S. Bombari, “Trustworthy machine learning in high dimensions,” Institute of Science and Technology Austria, 2026.","ama":"Bombari S. Trustworthy machine learning in high dimensions. 2026. doi:10.15479/AT-ISTA-22857"},"alternative_title":["ISTA Thesis"],"das_tickbox":"0","has_accepted_license":"1","publication_status":"published","file":[{"file_name":"Thesis copy.zip","file_id":"22859","relation":"source_file","checksum":"8eab99d6dc6e4476826bdfc7c00fdebb","creator":"sbombari","content_type":"application/zip","access_level":"closed","date_created":"2026-09-08T13:28:38Z","file_size":99154325,"date_updated":"2026-09-08T13:28:38Z"},{"content_type":"application/pdf","creator":"sbombari","access_level":"open_access","date_created":"2026-09-10T10:03:48Z","file_size":12856211,"date_updated":"2026-09-10T10:03:48Z","file_name":"2026_Bombari_Simone_Thesis.pdf","success":1,"file_id":"22898","relation":"main_file","checksum":"007033bafe4622ff4c2e758301354df1"}],"year":"2026","abstract":[{"lang":"eng","text":"Artificial intelligence and machine learning have undergone an unprecedented evolution in the past decade, motivating a research effort toward a theory able to capture the qualitative behavior of large-scale neural systems. A central puzzle has been the clear benefit of scaling architecture size and overfitting the training set in supervised learning tasks. This evidence, in apparent contradiction with classical statistical learning theory, pushed researchers to develop a new theory capturing the interplay between the algorithmic and architectural bias of training and the specific target function, differently from previous methods rooted in uniform stability.\r\nThis approach has enabled a grounded understanding of novel learning regimes, typically through formal limits where the number of training samples $n$, data dimensions $d$, and model parameters $p$ grow to infinity at different rates. \\\\\r\nIn this thesis, we follow this approach, focusing on the trustworthiness of high-dimensional models: properties that are difficult to control during training or deployment and often emerge under unpredictable or adversarial conditions. In such settings, it is crucial to formally ensure a priori the reliability of machine learning systems.\r\nFirst, we study data memorization, both as label fitting and as the storage of private information about training samples in trained parameters. We prove that $p = \\Omega(n)$ parameters are sufficient for a deep neural network to memorize a generic set of labels, and for a model to memorize spurious features across training data. We then give evidence that $p = \\Omega(dn)$ parameters are instead necessary for an adversary to reconstruct the full training set from the trained parameters.\r\nSecond, we study robustness, both to adversarial perturbations and to distribution shift. We first prove that $p = \\Omega(dn)$ parameters can be sufficient for a class of neural networks to overfit the training data while guaranteeing robustness to adversarial perturbations. Then, we focus on spurious correlations learning in high-dimensional regression, studying the effect of the ridge regularization parameter in the proportional regime $n = \\Theta(d)$, and connecting it via an equivalence argument to the role of over-parameterization $p = \\Omega(n)$ in neural networks. We also investigate the architectural bias of attention-based networks, showing that they are sensitive to the replacement of individual words in an embedded sentence, allowing them to generalize on sentences where the contextual meaning depends on one or few words.\r\nFinally, we study differentially private optimization in high-dimensional regimes. We prove that standard private gradient methods do not suffer in the over-parameterized regime $p = \\Omega(n)$, challenging the current wisdom based on stability-derived generalization bounds. We then consider linear regression in the proportional regime $n = \\Theta(d)$, showing that standard private gradient descent can achieve optimal rates under appropriate hyper-parameter scaling, such as sufficiently small gradient clipping constants, whose role is still debated in practice."}],"status":"public","title":"Trustworthy machine learning in high dimensions","corr_author":"1","acknowledgement":"This project was partially supported by the 2019 Lopez-Loreta prize,\r\nthe European Union (ERC, INF2\r\n, project number 101161364), the Austrian Science Fund\r\n(FWF) 10.55776/COE12, and a Google PhD fellowship in machine intelligence. Furthermore,\r\nthe candidate acknowledges the support from the Scientific Service Units of the Institute of\r\nScience and Technology Austria through resources provided by Scientific Computing.","OA_place":"publisher","supplementarymaterial":"no"},{"intvolume":" 17","fulldoi":"https://doi.org/10.1038/s41467-026-76877-7","language":[{"iso":"eng"}],"oa":1,"scopus_import":"1","acknowledged_ssus":[{"_id":"ScienComp"}],"author":[{"orcid":"0000-0001-6617-9742","first_name":"Nick N","id":"3591A0AA-F248-11E8-B48F-1D18A9856A87","full_name":"Machnik, Nick N","last_name":"Machnik"},{"first_name":"Seyed Mahdi","id":"b9f6d5ef-7774-11eb-a47f-df2c75c02ee7","full_name":"Mahmoudi, Seyed Mahdi","last_name":"Mahmoudi"},{"first_name":"Malgorzata","last_name":"Borczyk","full_name":"Borczyk, Malgorzata"},{"orcid":"0000-0002-5636-9259","id":"30d4014e-7753-11eb-b44b-db6d61112e73","first_name":"Ilse","last_name":"Krätschmer","full_name":"Krätschmer, Ilse"},{"full_name":"Bauer, Markus J.","last_name":"Bauer","first_name":"Markus J."},{"last_name":"Robinson","full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","orcid":"0000-0001-8982-8813"}],"OA_type":"gold","article_processing_charge":"Yes","department":[{"_id":"MaRo"}],"article_number":"10153 ","file_date_updated":"2026-10-07T09:50:18Z","ddc":["570"],"volume":17,"article_type":"original","oa_version":"Published Version","publisher":"Springer Nature","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-04T22:01:53Z","related_material":{"record":[{"relation":"earlier_version","id":"18648","status":"public"}]},"date_updated":"2026-10-16T11:01:16Z","type":"journal_article","month":"08","doi":"10.1038/s41467-026-76877-7","date_published":"2026-08-25T00:00:00Z","publication_identifier":{"eissn":["2041-1723"]},"researchdata_availability":"yes","_id":"23043","quality_controlled":"1","publication":"Nature Communications","das_tickbox":"1","day":"25","citation":{"apa":"Machnik, N. N., Mahmoudi, S. M., Borczyk, M., Krätschmer, I., Bauer, M. J., & Robinson, M. R. (2026). Causal inference for multiple risk factors and diseases from genomics data. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-76877-7","ieee":"N. N. Machnik, S. M. Mahmoudi, M. Borczyk, I. Krätschmer, M. J. Bauer, and M. R. Robinson, “Causal inference for multiple risk factors and diseases from genomics data,” Nature Communications, vol. 17. Springer Nature, 2026.","ama":"Machnik NN, Mahmoudi SM, Borczyk M, Krätschmer I, Bauer MJ, Robinson MR. Causal inference for multiple risk factors and diseases from genomics data. Nature Communications. 2026;17. doi:10.1038/s41467-026-76877-7","ista":"Machnik NN, Mahmoudi SM, Borczyk M, Krätschmer I, Bauer MJ, Robinson MR. 2026. Causal inference for multiple risk factors and diseases from genomics data. Nature Communications. 17, 10153.","short":"N.N. Machnik, S.M. Mahmoudi, M. Borczyk, I. Krätschmer, M.J. Bauer, M.R. Robinson, Nature Communications 17 (2026).","mla":"Machnik, Nick N., et al. “Causal Inference for Multiple Risk Factors and Diseases from Genomics Data.” Nature Communications, vol. 17, 10153, Springer Nature, 2026, doi:10.1038/s41467-026-76877-7.","chicago":"Machnik, Nick N, Seyed Mahdi Mahmoudi, Malgorzata Borczyk, Ilse Krätschmer, Markus J. Bauer, and Matthew Richard Robinson. “Causal Inference for Multiple Risk Factors and Diseases from Genomics Data.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-76877-7."},"publication_status":"published","has_accepted_license":"1","file":[{"date_updated":"2026-10-07T09:50:18Z","file_size":2345578,"creator":"dernst","content_type":"application/pdf","date_created":"2026-10-07T09:50:18Z","access_level":"open_access","checksum":"05517674168a275c70f18e964ce33d8b","relation":"main_file","file_name":"2026_NatureComm_Machnik.pdf","file_id":"23070","success":1}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"year":"2026","abstract":[{"lang":"eng","text":"Mendelian randomization, the standard instrument variable causal-inference approach for genomics, can be severely biased by inadequate selection of appropriate instrument variables and horizontal pleiotropy. We introduce Causal Inference GWAS, a graphical approach that selects genetic instruments from summary statistics controlling for linkage and pleiotropy, accommodates rare variants and binary outcomes, distinguishes direct from indirect risk factors in high dimensions, and flags latent confounding. Applied to 9 risk factors, 4 metabolic disease outcomes, and 8.4M variants across 458,747 UK Biobank individuals, our method runs in 20 minutes, identifying only 696 genome-wide valid instruments. We replicate nearly all previously reported risk factor-outcome paths, but find that most are indistinguishable from unmeasured confounding. This suggests robust biobank causal inference will require longitudinal and family data to resolve temporal precedence from reverse causation. Our approach offers a principled first step toward screening genuine causal signal from phenotypic correlation in biobank data."}],"dataavailabilitystatement":"This project uses the UK Biobank data under project number 35520.\r\nUK Biobank genotypic and phenotypic data is available through a\r\nformal request at (http://www.ukbiobank.ac.uk). All of the data generated\r\nin this study are provided in the Source Data file. Source data\r\nare provided with this paper. The CI-GWAS code is fully open source and available at https://github.\r\ncom/medical-genomics-group/ci-gwasand has been archived on\r\nZenodo52. The scripts used to execute the model are available at\r\nhttps://github.com/medical-genomics-group/ci-gwas. R version 4.2.1 is\r\navailable at https://www.r-project.org/. Plink version 1.9 is available at\r\nhttps://www.cog-genomics.org/plink/1.9/.","corr_author":"1","title":"Causal inference for multiple risk factors and diseases from genomics data","status":"public","acknowledgement":"We thank Zoltan Kutalik andmembers of the Robinson group at ISTA for\r\ntheir comments, which improved this manuscript. We would like to\r\nacknowledge the participants and investigators of the UK Biobank study.\r\nHigh-performance computing was supported by the Scientific Service\r\nUnits (SSU) of IST Austria through resources provided by Scientific\r\nComputing (SciComp). This work was funded by a research collaboration agreement between\r\nBoehringer Ingelheim and the research group of MRR at the Institute of\r\nScience and Technology Austria. Additional funding was also provided\r\nby an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core\r\nfunding from the Institute of Science and Technology Austria. MB was\r\nfunded by the National Science Center Poland grant SONATINA UMO-\r\n2021/40/C/NZ2/00218.","OA_place":"publisher","DOAJ_listed":"1","supplementarymaterial":"no"},{"year":"2026","abstract":[{"text":"We present a panchromatic optical-millimeter characterization of GNz7q, a recently identified X-ray-weak,\r\nrapidly growing red quasar embedded within a dusty starburst galaxy at z = 7.1899, using the full suite of JWST/\r\nNIRCam, NIRSpec, Mid-Infrared Instrument (MIRI), and archival NOEMA observations. Our deep NIRSpec/\r\nG395M spectroscopy reveals unambiguous broad Balmer emission (FWHM = 2221 ± 20 km s\r\n−1\r\n), confirming a\r\nsuper-Eddington accreting black hole (BH) (λEdd = 2.7 ± 0.4) with a mass of\r\nlog(MBH/M ) = 7.55 ± 0.34,\r\nusing accretion-rate-corrected BH mass estimators. After subtracting the point source, we robustly detect stellar\r\nemission from the host galaxy across multiple NIRCam and MIRI filters. Our joint morphological-spectral\r\nanalysis yields a stellar mass of = ± * log(M /M ) 10.5 0.4\r\nand an intense star formation rate of\r\nSFR = 330 ± 97 M⊙ yr−1\r\n, confirming the host as a massive, dusty starburst galaxy. We find that GNz7q lies\r\non the local MBH–M* relation (MBH/M* ≃ 0.001) and is well positioned to evolve into the locus of massive Sloan\r\nDigital Sky Survey (SDSS) quasars with\r\nlog(MBH/M ) 9\r\nand M* ≈ 1011 M⊙ at z ∼ 6, owing to its remarkably\r\nrapid growth in both the BH and its host galaxy. This stands in stark contrast to many recently reported JWST\r\nactive galactic nucleus populations at similar redshifts, including the little red dots, whose weak or undetected star\r\nformation makes it difficult for them to grow into the massive galaxies hosting SDSS-like quasars. These results\r\nsuggest that GNz7q marks a rare, pivotal phase of early BH–galaxy coevolution, plausibly providing a crucial\r\ndirect pathway to the supermassive BH systems within the first billion years of the Universe.","lang":"eng"}],"dataavailabilitystatement":"The reduced 1D NIRSpec/G395M spectra, the MIRI LRS 1D extraction, and the MIRI MRS 1D extraction used in this work are publicly available on Zenodo at DOI: 10.5281/zenodo.21539999.\r\nFacilities: JWST - James Webb Space Telescope, IRAM:NOEMA. -\r\nSoftware: GalfitS (R. Li et al. 2026), LMFIT (M. Newville et al. 2014), grizli (G. Brammer & J. Matharu 2021), msaexp (G. Brammer 2023)","status":"public","title":"Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2","OA_place":"publisher","acknowledgement":"We are grateful to Jinyi Yang and Feige Wang for their insightful discussions about the broad-line fitting. We are grateful to Zhiwei Pan and Yuming Fu for their discussions about the BH mass estimator.\r\n\r\nK.I. acknowledges support from the National Natural Science Foundation of China (12573015, W2532003), the Beijing Natural Science Foundation (IS25003), and the China Manned Space Program (CMS-CSST-2025-A09). LCH was supported by the National Science Foundation of China (12233001) and the China Manned Space Program (CMS-CSST-2025-A09). P.G.P.-G. acknowledges support from grant PID2022-139567NB-I00 funded by the Spanish Ministerio de Ciencia, Innovación y Universidades MCIU/AEI/10.13039/501100011033, FEDER Una manera de hacer Europa. J.A.-M. acknowledges support by grants PID2024-158856NA-I00 & PIB2021-127718NB-I00 from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe.”\r\n\r\nThis work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. The specific observations analyzed can be accessed via DOI: 10.17909/q19z-a348for the GNz7q observations and DOI: 10.17909/0akt-xx69for the MIRI images from the MEOW survey. These observations are associated with programs # 4762 and # 5407.","DOAJ_listed":"1","supplementarymaterial":"yes","_id":"23152","quality_controlled":"1","das_tickbox":"1","publication":"The Astrophysical Journal","citation":{"mla":"Fei, Qinyue, et al. “Direct Pathway to the Early Supermassive Black Holes: A Red Super-Eddington Quasar in a Massive Starburst Host at z = 7.2.” The Astrophysical Journal, vol. 1010, no. 1, 86, IOP Publishing, 2026, doi:10.3847/1538-4357/aea07b.","chicago":"Fei, Qinyue, Seiji Fujimoto, Gabriel Brammer, Ruancun Li, Luis C. Ho, Volker Bromm, Javier Álvarez-Márquez, et al. “Direct Pathway to the Early Supermassive Black Holes: A Red Super-Eddington Quasar in a Massive Starburst Host at z = 7.2.” The Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/aea07b.","short":"Q. Fei, S. Fujimoto, G. Brammer, R. Li, L.C. Ho, V. Bromm, J. Álvarez-Márquez, Y. Asada, G. Barro, L. Colina, P. Dayal, S.L. Finkelstein, J.P.U. Fynbo, M. Ginolfi, K. Inayoshi, V. Kokorev, G.C.K. Leung, J.J. Matthee, R.A. Meyer, R.P. Naidu, M. Onoue, P.G. Pérez-González, C.L. Steinhardt, F. Valentino, F. Walter, M. Xiao, H. Zhang, The Astrophysical Journal 1010 (2026).","ista":"Fei Q, Fujimoto S, Brammer G, Li R, Ho LC, Bromm V, Álvarez-Márquez J, Asada Y, Barro G, Colina L, Dayal P, Finkelstein SL, Fynbo JPU, Ginolfi M, Inayoshi K, Kokorev V, Leung GCK, Matthee JJ, Meyer RA, Naidu RP, Onoue M, Pérez-González PG, Steinhardt CL, Valentino F, Walter F, Xiao M, Zhang H. 2026. Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2. The Astrophysical Journal. 1010(1), 86.","ama":"Fei Q, Fujimoto S, Brammer G, et al. Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2. The Astrophysical Journal. 2026;1010(1). doi:10.3847/1538-4357/aea07b","ieee":"Q. Fei et al., “Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2,” The Astrophysical Journal, vol. 1010, no. 1. IOP Publishing, 2026.","apa":"Fei, Q., Fujimoto, S., Brammer, G., Li, R., Ho, L. C., Bromm, V., … Zhang, H. (2026). Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/aea07b"},"day":"10","publication_status":"published","has_accepted_license":"1","file":[{"relation":"main_file","checksum":"b319631e496b3f50fd32202bb19a5b99","success":1,"file_id":"23162","file_name":"2026_AstrophysicalJour_FeiQinyue.pdf","file_size":3985652,"date_updated":"2026-10-19T06:36:24Z","access_level":"open_access","date_created":"2026-10-19T06:36:24Z","creator":"dernst","content_type":"application/pdf"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.3847/1538-4357/aea07b","date_published":"2026-10-10T00:00:00Z","arxiv":1,"external_id":{"arxiv":["2602.12325"]},"publication_identifier":{"eissn":["1538-4357"],"issn":["0004-637X"]},"researchdata_availability":"yes","type":"journal_article","month":"10","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-18T22:01:51Z","PlanS_conform":"1","date_updated":"2026-10-19T06:48:25Z","file_date_updated":"2026-10-19T06:36:24Z","ddc":["520"],"volume":1010,"article_type":"original","oa_version":"Published Version","publisher":"IOP Publishing","oa":1,"scopus_import":"1","OA_type":"gold","author":[{"full_name":"Fei, Qinyue","last_name":"Fei","first_name":"Qinyue"},{"last_name":"Fujimoto","full_name":"Fujimoto, Seiji","first_name":"Seiji"},{"last_name":"Brammer","full_name":"Brammer, Gabriel","first_name":"Gabriel"},{"first_name":"Ruancun","full_name":"Li, Ruancun","last_name":"Li"},{"first_name":"Luis C.","full_name":"Ho, Luis C.","last_name":"Ho"},{"first_name":"Volker","last_name":"Bromm","full_name":"Bromm, Volker"},{"first_name":"Javier","full_name":"Álvarez-Márquez, Javier","last_name":"Álvarez-Márquez"},{"first_name":"Yoshihisa","last_name":"Asada","full_name":"Asada, Yoshihisa"},{"last_name":"Barro","full_name":"Barro, Guillermo","first_name":"Guillermo"},{"first_name":"Luis","full_name":"Colina, Luis","last_name":"Colina"},{"first_name":"Pratika","full_name":"Dayal, Pratika","last_name":"Dayal"},{"full_name":"Finkelstein, Steven L.","last_name":"Finkelstein","first_name":"Steven L."},{"last_name":"Fynbo","full_name":"Fynbo, Johan P.U.","first_name":"Johan P.U."},{"full_name":"Ginolfi, Michele","last_name":"Ginolfi","first_name":"Michele"},{"full_name":"Inayoshi, Kohei","last_name":"Inayoshi","first_name":"Kohei"},{"last_name":"Kokorev","full_name":"Kokorev, Vasily","first_name":"Vasily"},{"full_name":"Leung, Gene C.K.","last_name":"Leung","first_name":"Gene C.K."},{"last_name":"Matthee","full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720","first_name":"Jorryt J","orcid":"0000-0003-2871-127X"},{"full_name":"Meyer, Romain A.","last_name":"Meyer","first_name":"Romain A."},{"first_name":"Rohan P.","last_name":"Naidu","full_name":"Naidu, Rohan P."},{"first_name":"Masafusa","last_name":"Onoue","full_name":"Onoue, Masafusa"},{"last_name":"Pérez-González","full_name":"Pérez-González, Pablo G.","first_name":"Pablo G."},{"first_name":"Charles L.","full_name":"Steinhardt, Charles L.","last_name":"Steinhardt"},{"first_name":"Francesco","full_name":"Valentino, Francesco","last_name":"Valentino"},{"full_name":"Walter, Fabian","last_name":"Walter","first_name":"Fabian"},{"first_name":"Mengyuan","full_name":"Xiao, Mengyuan","last_name":"Xiao"},{"first_name":"Haowen","full_name":"Zhang, Haowen","last_name":"Zhang"}],"department":[{"_id":"JoMa"}],"article_processing_charge":"Yes","article_number":"86","issue":"1","intvolume":" 1010","fulldoi":"https://doi.org/10.3847/1538-4357/aea07b","language":[{"iso":"eng"}]},{"researchdata_availability":"upon request","publication_identifier":{"eissn":["2399-3642"]},"external_id":{"pmid":["42387039"]},"doi":"10.1038/s42003-026-10581-6","date_published":"2026-10-08T00:00:00Z","month":"10","type":"journal_article","supplementarymaterial":"yes","OA_place":"publisher","acknowledgement":"We appreciate the technical assistance from Anna Schreilechner. We are grateful for support by all members of the animal facility team at IMB, University of Graz, as well as K. Zierler for assistance with animal licenses. F.M, T.E., T.M., T.P., and W.F.G. are grateful to the Austrian Science Fund (FWF) for the excellence cluster 10.55776/COE14 (MetAGE), which was additionally supported by Land Styria, Stadt Graz, University of Graz and Medical University of Graz. This research was further supported by the FWF via the DKplus program 10.55776/W1226 (DK-MCD) to F.M., T.M., R.B.G., and W.F.G., 10.55776/P28529, 10.55776/I3716 (to R.M.), 10.55776/P28854, 10.55776/I3792, 10.55776/DOC130 (to T.M.), and 10.55776/I4319 (to. M.S.R.); the Austrian Research Promotion Agency (FFG) grants 864690 and 870454; the Integrative Metabolism Research Center Graz; the Austrian Infrastructure Program 2016/2017 (to T.M.), and 10.55776/COE7, 10.55776/COE17, 10.55776/FG12 and 10.55776/F73 (to R.B.G.); the Styrian Government; the City of Graz; and BioTechMed-Graz (flagship project) (to T.M.); the MEFO Graz (to W.F.G.). F.E.O., J.G. and Z.K. were doctoral fellows in the doctoral program Metabolic and Cardiovascular Disease (MCD) (FWF, 10.55776/W 1226) at the Medical University of Graz. S.v.A. and A.S. are thesis students in the excellence cluster 10.55776/COE14 (MetAGE, W.F.G.). M.H. was a fellow of the Molecular Medicine (MolMed) doctoral program at the Medical University of Graz supported by MEFO Graz. The SIM equipment is part of the Nikon Center of Excellence, Graz, and is supported by the Austrian infrastructure program 2013/ 2014, Nikon Austria Inc., and BioTechMed (to W.F.G.). Our thanks go to Shimadzu Austria for supporting this research through instrument access given in the Metabolomics and Bioprocess Analytics laboratory (TU Wien) (R.B.G.). For open access purposes, the authors have applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission.” We thank the Medical University of Graz for financial support.","DOAJ_listed":"1","title":"Presenilin-1 controls glycolysis and identity of pancreatic beta cells","status":"public","year":"2026","abstract":[{"lang":"eng","text":"Presenilin-1 (PS1) is an endoplasmic reticulum protein, most known for its role in pathogenesis of familial Alzheimer’s Disease (AD). PS1 has been attributed roles in intracellular calcium homeostasis in the brain, as well as in the pancreatic beta cells, where it has been shown to be fundamental for the initial phase of glucose-induced insulin secretion. To gain mechanistic insight into beta cell autonomous function of PS1, we have examined various beta cell models and found that PS1 controls glycolytic flux of pancreatic beta cells by regulating sub-mitochondrial Ca2+ homeostasis. Transient knock down of PS1 yielded a glycolytic bottleneck at the step catalyzed by glyceraldehyde-3-phosphate dehydrogenase, resulting in defective glucose responsiveness. Moreover, we show that PS1 is needed for the preservation of beta cell identity, likely due to its role in glycolysis. Finally, we show that mouse islets from an in vivo model of AD mimic the defective glucose responsiveness seen in beta cells with transient PS1 knock down, while the identity loss and whole-body glucose homeostasis are not severely impacted, suggesting an adaptive response. Thus, the current work highlights beta cell autonomous role of PS1 and adds a layer of complexity in its impact on whole body metabolism."}],"dataavailabilitystatement":"The data supporting the findings of this research can be obtained from the authors upon a reasonable request; please refer to the author’s contributions for details regarding specific datasets. Numerical source data underlying graphs in this article can be found in Supplementary data file. Supplementary Figs. and figure legends are included in the Supplementary file. The code used in this study is available from the authors on reasonable request.","file":[{"relation":"main_file","checksum":"b90e60a625fcac8ef5d9ff968792d675","file_name":"2026_CommunicationsBiology_Koshenov.pdf","success":1,"file_id":"23161","file_size":1819866,"date_updated":"2026-10-19T06:19:39Z","creator":"dernst","content_type":"application/pdf","access_level":"open_access","date_created":"2026-10-19T06:19:39Z"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","publication_status":"published","publication":"Communications Biology","quality_controlled":"1","das_tickbox":"1","citation":{"chicago":"Koshenov, Zhanat, Sandra Postic, Gabriela Schoiswohl, Savina Van Amsterdam, Victoria Hois-Zelinka, Furkan E. Oflaz, Rene Rost, et al. “Presenilin-1 Controls Glycolysis and Identity of Pancreatic Beta Cells.” Communications Biology. Springer Nature, 2026. https://doi.org/10.1038/s42003-026-10581-6.","mla":"Koshenov, Zhanat, et al. “Presenilin-1 Controls Glycolysis and Identity of Pancreatic Beta Cells.” Communications Biology, vol. 9, 1315, Springer Nature, 2026, doi:10.1038/s42003-026-10581-6.","ista":"Koshenov Z, Postic S, Schoiswohl G, Van Amsterdam S, Hois-Zelinka V, Oflaz FE, Rost R, Tiapko O, Gottschalk B, Hirtl M, Bachkoenig OG, Koshenova A, Erdogan YC, Sagintayev A, Krnjic A, Pfabe JU, Sarikas S, Hochreiter B, Gindlhuber J, Schittmayer M, Tadic J, Ehall B, Madeo F, Madl T, Malli R, Birner-Gruenberger R, Pieber T, Eisenberg T, Slak Rupnik M, Graier WF. 2026. Presenilin-1 controls glycolysis and identity of pancreatic beta cells. Communications Biology. 9, 1315.","short":"Z. Koshenov, S. Postic, G. Schoiswohl, S. Van Amsterdam, V. Hois-Zelinka, F.E. Oflaz, R. Rost, O. Tiapko, B. Gottschalk, M. Hirtl, O.G. Bachkoenig, A. Koshenova, Y.C. Erdogan, A. Sagintayev, A. Krnjic, J.U. Pfabe, S. Sarikas, B. Hochreiter, J. Gindlhuber, M. Schittmayer, J. Tadic, B. Ehall, F. Madeo, T. Madl, R. Malli, R. Birner-Gruenberger, T. Pieber, T. Eisenberg, M. Slak Rupnik, W.F. Graier, Communications Biology 9 (2026).","ieee":"Z. Koshenov et al., “Presenilin-1 controls glycolysis and identity of pancreatic beta cells,” Communications Biology, vol. 9. Springer Nature, 2026.","ama":"Koshenov Z, Postic S, Schoiswohl G, et al. Presenilin-1 controls glycolysis and identity of pancreatic beta cells. Communications Biology. 2026;9. doi:10.1038/s42003-026-10581-6","apa":"Koshenov, Z., Postic, S., Schoiswohl, G., Van Amsterdam, S., Hois-Zelinka, V., Oflaz, F. E., … Graier, W. F. (2026). Presenilin-1 controls glycolysis and identity of pancreatic beta cells. Communications Biology. Springer Nature. https://doi.org/10.1038/s42003-026-10581-6"},"day":"08","_id":"23148","article_number":"1315","author":[{"first_name":"Zhanat","full_name":"Koshenov, Zhanat","last_name":"Koshenov"},{"first_name":"Sandra","last_name":"Postic","full_name":"Postic, Sandra"},{"first_name":"Gabriela","full_name":"Schoiswohl, Gabriela","last_name":"Schoiswohl"},{"last_name":"Van Amsterdam","full_name":"Van Amsterdam, Savina","first_name":"Savina"},{"last_name":"Hois-Zelinka","full_name":"Hois-Zelinka, Victoria","first_name":"Victoria"},{"last_name":"Oflaz","full_name":"Oflaz, Furkan E.","first_name":"Furkan E."},{"full_name":"Rost, Rene","last_name":"Rost","first_name":"Rene"},{"full_name":"Tiapko, Oleksandra","last_name":"Tiapko","first_name":"Oleksandra"},{"first_name":"Benjamin","last_name":"Gottschalk","full_name":"Gottschalk, Benjamin"},{"first_name":"Martin","full_name":"Hirtl, Martin","last_name":"Hirtl"},{"first_name":"Olaf G.","full_name":"Bachkoenig, Olaf G.","last_name":"Bachkoenig"},{"first_name":"Aigerim","last_name":"Koshenova","full_name":"Koshenova, Aigerim"},{"full_name":"Erdogan, Yusuf C.","last_name":"Erdogan","first_name":"Yusuf C."},{"last_name":"Sagintayev","full_name":"Sagintayev, Adlet","first_name":"Adlet"},{"first_name":"Anita","full_name":"Krnjic, Anita","last_name":"Krnjic"},{"last_name":"Pfabe","full_name":"Pfabe, Johannes U.","first_name":"Johannes U."},{"id":"35F0286E-F248-11E8-B48F-1D18A9856A87","first_name":"Srdjan","last_name":"Sarikas","full_name":"Sarikas, Srdjan"},{"last_name":"Hochreiter","full_name":"Hochreiter, Bernhard","id":"e6cab3de-17f6-11ed-9210-c1e42e045e9d","first_name":"Bernhard"},{"last_name":"Gindlhuber","full_name":"Gindlhuber, Juergen","first_name":"Juergen"},{"last_name":"Schittmayer","full_name":"Schittmayer, Matthias","first_name":"Matthias"},{"full_name":"Tadic, Jelena","last_name":"Tadic","first_name":"Jelena"},{"full_name":"Ehall, Barbara","last_name":"Ehall","first_name":"Barbara"},{"first_name":"Frank","last_name":"Madeo","full_name":"Madeo, Frank"},{"first_name":"Tobias","full_name":"Madl, Tobias","last_name":"Madl"},{"first_name":"Roland","last_name":"Malli","full_name":"Malli, Roland"},{"full_name":"Birner-Gruenberger, Ruth","last_name":"Birner-Gruenberger","first_name":"Ruth"},{"last_name":"Pieber","full_name":"Pieber, Thomas","first_name":"Thomas"},{"first_name":"Tobias","full_name":"Eisenberg, Tobias","last_name":"Eisenberg"},{"last_name":"Slak Rupnik","full_name":"Slak Rupnik, Marjan","first_name":"Marjan"},{"full_name":"Graier, Wolfgang F.","last_name":"Graier","first_name":"Wolfgang F."}],"OA_type":"gold","article_processing_charge":"Yes","department":[{"_id":"FISS"}],"scopus_import":"1","oa":1,"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1038/s42003-026-10581-6","intvolume":" 9","date_updated":"2026-10-19T06:23:26Z","PlanS_conform":"1","date_created":"2026-10-18T22:01:50Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"publisher":"Springer Nature","article_type":"original","oa_version":"Published Version","volume":9,"file_date_updated":"2026-10-19T06:19:39Z","ddc":["570"]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-18T22:01:51Z","date_updated":"2026-10-19T07:05:55Z","ddc":["520"],"file_date_updated":"2026-10-19T07:05:43Z","volume":552,"oa_version":"Published Version","article_type":"original","publisher":"Oxford University Press","oa":1,"scopus_import":"1","department":[{"_id":"ZoHa"}],"author":[{"first_name":"Matthew T.","full_name":"Scoggins, Matthew T.","last_name":"Scoggins"},{"id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","first_name":"Zoltán","orcid":"0000-0003-3633-5403","last_name":"Haiman","full_name":"Haiman, Zoltán"},{"first_name":"Fabio","last_name":"Pacucci","full_name":"Pacucci, Fabio"}],"OA_type":"gold","article_processing_charge":"Yes","article_number":"stag1839","intvolume":" 552","issue":"3","fulldoi":"https://doi.org/10.1093/mnras/stag1839","language":[{"iso":"eng"}],"dataavailabilitystatement":"The code used to analyse the merger trees and generate figures for this manuscript is available at this GitHub repository. All other data will be shared upon reasonable request to the corresponding author.","abstract":[{"lang":"eng","text":"High-redshift supermassive black holes (SMBHs) have challenged our understanding of black hole formation and growth. The ‘heavy-seed’ pathway eases the problem with the progenitors of these SMBHs having birth masses up to∼105 M\u0003. Here, we investigate the possibility that a local dwarf galaxy, Leo I, harbours a heavy-seed descendant. Using Monte Carlo merger trees to generate the merger histories of 1000 dark matter haloes similar to the Milky Way (MW), we search for Leo- like satellite haloes and investigate the probability that the progenitors of these satellites formed a heavy seed. We derive the likelihood of such ‘heavy-seed survivors’ (HSSs) across various formation and survival criteria as well as Leo-similarity criteria. We find that the virial temperature for the onset of atomic cooling and rapid gas infall that yields heavy seeds, Tact , has the largest impact on HSS frequency. We find HSSs in a fraction 0.7 per cent, 18.1 per cent, and 96.5 per cent of MW-like haloes when Tact is set to 9000, 7000, and 5000 K, respectively. For the canonical atomic-cooling threshold ( Tact \u0002 8000 K), the HSS fraction is\u0003 1per cent , indicating that Leo I hosting a heavy-seed descendant is unlikely under well-motivated physical assumptions. Higher HSS fractions occur only under optimistic and currently unsubstantiated assumptions on Tact . Nevertheless, these results motivate future work that clarifies the possibility of heavy-seed BH formation in pristine haloes with nominal virial temperatures below 8000 K. This may motivate Leo I as a target for disentangling heavy seeds from other SMBH formation mechanisms."}],"year":"2026","title":"Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I","status":"public","acknowledgement":"We thank the anonymous reviewer for feedback that helped clarify this manuscript. ZH acknowledges support from NSF grant AST-2006176. FP acknowledges support from the Black Hole Initiative at Harvard University, which is funded by grants from the John Templeton Foundation and the Gordon and Betty Moore Foundation. Merger tree generation and analysis were performed with NSF’s ACCESS allocations AST-120046 and AST-140041 on the Stampede3 resource. The freely available plotting library matplotlib (J. D. Hunter 2007) was used to construct the plots in this paper.","DOAJ_listed":"1","OA_place":"publisher","supplementarymaterial":"no","_id":"23150","day":"01","citation":{"ama":"Scoggins MT, Haiman Z, Pacucci F. Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I. Monthly Notices of the Royal Astronomical Society. 2026;552(3). doi:10.1093/mnras/stag1839","ieee":"M. T. Scoggins, Z. Haiman, and F. Pacucci, “Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I,” Monthly Notices of the Royal Astronomical Society, vol. 552, no. 3. Oxford University Press, 2026.","apa":"Scoggins, M. T., Haiman, Z., & Pacucci, F. (2026). Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stag1839","chicago":"Scoggins, Matthew T., Zoltán Haiman, and Fabio Pacucci. “Heavy Black Hole Seed Survivors in Dwarf Galaxies: A Case Study of Leo I.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2026. https://doi.org/10.1093/mnras/stag1839.","mla":"Scoggins, Matthew T., et al. “Heavy Black Hole Seed Survivors in Dwarf Galaxies: A Case Study of Leo I.” Monthly Notices of the Royal Astronomical Society, vol. 552, no. 3, stag1839, Oxford University Press, 2026, doi:10.1093/mnras/stag1839.","short":"M.T. Scoggins, Z. Haiman, F. Pacucci, Monthly Notices of the Royal Astronomical Society 552 (2026).","ista":"Scoggins MT, Haiman Z, Pacucci F. 2026. Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I. Monthly Notices of the Royal Astronomical Society. 552(3), stag1839."},"quality_controlled":"1","das_tickbox":"1","publication":"Monthly Notices of the Royal Astronomical Society","has_accepted_license":"1","publication_status":"published","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_updated":"2026-10-19T07:05:43Z","file_size":1450204,"date_created":"2026-10-19T07:05:43Z","access_level":"open_access","creator":"dernst","content_type":"application/pdf","checksum":"99a35f1305b7f1ed3813bcd51ba16724","relation":"main_file","file_id":"23164","success":1,"file_name":"2026_MonthNoticesRAS_Scoggins.pdf"}],"date_published":"2026-11-01T00:00:00Z","doi":"10.1093/mnras/stag1839","arxiv":1,"external_id":{"arxiv":["2511.04736"]},"researchdata_availability":"yes","publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]},"type":"journal_article","month":"11"},{"year":"2026","abstract":[{"lang":"eng","text":"We present deep, narrowband Gemini North/GMOS images of the Pa 30 nebula that reveal rich small-scale\r\nstructure in the ejecta filaments. In [S II], the number of detected filaments increases by about an order of\r\nmagnitude compared to previous studies. The imaging further reveals that the filaments are not smooth radial\r\nstreaks, but instead are composed of cascades of knots or clumps. The images in [O III] yield the first confirmation\r\nthat previously detected diffuse [O III] emission in fact originates from the same [S II] filaments. We measure a\r\nnebula center consistent with the position of the central star, indicating that the remnant has not received a large\r\ntransverse kick. The 3σ upper limit on the velocity of the stellar kick is ≲100 km s\r\n−1\r\n. Cross-sectional profiles of\r\nthe filaments in [S II] and [O III] show a central peak on top of a nebula background, the latter being likely due to\r\ndiffuse emission or unresolved filaments. The median [S II] width of 0.7 is slightly broader than the 0.50 seeing,\r\nproviding some evidence of partially resolved filaments and implying a characteristic knot diameter of ∼1016 cm.\r\nThe ≈1″ widths measured in [O III] are consistent with the poorer seeing of the oxygen images. The discovery of\r\nthis clumpy substructure provides a new observational constraint on models for the origin and evolution of the\r\nremarkable filamentary ejecta of Pa 30."}],"title":"Detection of knots in the type Iax supernova remnant Pa 30","status":"public","corr_author":"1","OA_place":"publisher","DOAJ_listed":"1","acknowledgement":"We thank Jim Fuller, SR Kulkarni, David Charbonneau, Paul Duffell, Abigail Polin, Miranda Pikus, Tony Piro, Lars Bildsten, Eliot Quartert, and Rob Fesen for helpful discussions. This work was supported by NASA through the NASA Hubble Fellowship grant HST-HF2-51527.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555.\r\n\r\nFacility: Gemini:Gillett (GMOS-N) - .\r\n\r\nSoftware: astropy (Astropy Collaboration et al. 2013, 2018), scipy (P. Virtanen et al. 2020), emcee (D. Foreman-Mackey et al. 2013), DRAGONS (K. Labrie et al. 2023), DS9 (W. A. Joye & E. Mandel 2003).","supplementarymaterial":"yes","_id":"23151","citation":{"ieee":"T. Cunningham, I. Caiazzo, J. C. Raymond, and S. J. Kenyon, “Detection of knots in the type Iax supernova remnant Pa 30,” The Astrophysical Journal, vol. 1010, no. 1. IOP Publishing, 2026.","ama":"Cunningham T, Caiazzo I, Raymond JC, Kenyon SJ. Detection of knots in the type Iax supernova remnant Pa 30. The Astrophysical Journal. 2026;1010(1). doi:10.3847/1538-4357/ae9cb2","apa":"Cunningham, T., Caiazzo, I., Raymond, J. C., & Kenyon, S. J. (2026). Detection of knots in the type Iax supernova remnant Pa 30. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae9cb2","mla":"Cunningham, Tim, et al. “Detection of Knots in the Type Iax Supernova Remnant Pa 30.” The Astrophysical Journal, vol. 1010, no. 1, 28, IOP Publishing, 2026, doi:10.3847/1538-4357/ae9cb2.","chicago":"Cunningham, Tim, Ilaria Caiazzo, John C. Raymond, and Scott J. Kenyon. “Detection of Knots in the Type Iax Supernova Remnant Pa 30.” The Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae9cb2.","ista":"Cunningham T, Caiazzo I, Raymond JC, Kenyon SJ. 2026. Detection of knots in the type Iax supernova remnant Pa 30. The Astrophysical Journal. 1010(1), 28.","short":"T. Cunningham, I. Caiazzo, J.C. Raymond, S.J. Kenyon, The Astrophysical Journal 1010 (2026)."},"day":"10","das_tickbox":"0","publication":"The Astrophysical Journal","quality_controlled":"1","publication_status":"published","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"relation":"main_file","checksum":"a31da77f9197b832da52caf1417a87de","file_name":"2026_AstrophysicalJour_Cunningham.pdf","success":1,"file_id":"23163","file_size":34494943,"date_updated":"2026-10-19T06:57:17Z","creator":"dernst","content_type":"application/pdf","access_level":"open_access","date_created":"2026-10-19T06:57:17Z"}],"doi":"10.3847/1538-4357/ae9cb2","date_published":"2026-10-10T00:00:00Z","arxiv":1,"external_id":{"arxiv":["2610.06424"]},"publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"researchdata_availability":"no","type":"journal_article","month":"10","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-18T22:01:51Z","PlanS_conform":"1","date_updated":"2026-10-19T06:59:28Z","file_date_updated":"2026-10-19T06:57:17Z","ddc":["520"],"volume":1010,"oa_version":"Published Version","article_type":"original","publisher":"IOP Publishing","oa":1,"scopus_import":"1","OA_type":"gold","department":[{"_id":"IlCa"}],"article_processing_charge":"Yes","author":[{"first_name":"Tim","full_name":"Cunningham, Tim","last_name":"Cunningham"},{"full_name":"Caiazzo, Ilaria","last_name":"Caiazzo","first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","orcid":"0000-0002-4770-5388"},{"first_name":"John C.","full_name":"Raymond, John C.","last_name":"Raymond"},{"first_name":"Scott J.","full_name":"Kenyon, Scott J.","last_name":"Kenyon"}],"article_number":"28","intvolume":" 1010","issue":"1","fulldoi":"https://doi.org/10.3847/1538-4357/ae9cb2","language":[{"iso":"eng"}]},{"supplementarymaterial":"no","OA_place":"publisher","acknowledgement":"Open Access funding enabled and organized by Projekt DEAL. We would like to thank the referee for their careful reading and helpful remarks that helped to improve this article. The first two authors were supported by the Deutsche Forschungsgemeinschaft (DFG) – 512730679 (RTG2965). The third author was partially supported by the Caroline Herschel Programme of Leibniz University Hannover. The fourth author was supported by the Deutsche Forschungsgemeinschaft (DFG) – 398436923 (RTG2491).","title":"Integral points over number fields: a Clemens complex jigsaw puzzle","status":"public","dataavailabilitystatement":"Our manuscript has no associated data.","abstract":[{"text":"We prove an asymptotic formula for the number of integral points of bounded log anticanonical height on a singular quartic del Pezzo surface over arbitrary number fields, with respect to the largest admissible boundary divisor. The resulting Clemens complex is more complicated than usual, and leads to particularly interesting effective cone constants, associated with exponentially many polytopes whose volumes appear in the expected formula. Like a jigsaw puzzle, these polytopes fit together to one large polytope. The volume of this polytope appears in the asymptotic formula that we obtain using the universal torsor method via o-minimal structures.","lang":"eng"}],"year":"2026","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_updated":"2026-10-19T06:11:23Z","file_size":593086,"date_created":"2026-10-19T06:11:23Z","access_level":"open_access","creator":"dernst","content_type":"application/pdf","checksum":"c2157633b4832a760336cd5d3f77b022","relation":"main_file","file_id":"23160","success":1,"file_name":"2026_MathemZeitschrift_Bernert.pdf"}],"publication_status":"published","has_accepted_license":"1","day":"01","citation":{"ieee":"C. Bernert, U. Derenthal, J. Ortmann, and F. A. Wilsch, “Integral points over number fields: a Clemens complex jigsaw puzzle,” Mathematische Zeitschrift, vol. 314, no. 3. Springer, 2026.","ama":"Bernert C, Derenthal U, Ortmann J, Wilsch FA. Integral points over number fields: a Clemens complex jigsaw puzzle. Mathematische Zeitschrift. 2026;314(3). doi:10.1007/s00209-026-04140-2","apa":"Bernert, C., Derenthal, U., Ortmann, J., & Wilsch, F. A. (2026). Integral points over number fields: a Clemens complex jigsaw puzzle. Mathematische Zeitschrift. Springer. https://doi.org/10.1007/s00209-026-04140-2","mla":"Bernert, Christian, et al. “Integral Points over Number Fields: A Clemens Complex Jigsaw Puzzle.” Mathematische Zeitschrift, vol. 314, no. 3, 37, Springer, 2026, doi:10.1007/s00209-026-04140-2.","chicago":"Bernert, Christian, Ulrich Derenthal, Judith Ortmann, and Florian Alexander Wilsch. “Integral Points over Number Fields: A Clemens Complex Jigsaw Puzzle.” Mathematische Zeitschrift. Springer, 2026. https://doi.org/10.1007/s00209-026-04140-2.","short":"C. Bernert, U. Derenthal, J. Ortmann, F.A. Wilsch, Mathematische Zeitschrift 314 (2026).","ista":"Bernert C, Derenthal U, Ortmann J, Wilsch FA. 2026. Integral points over number fields: a Clemens complex jigsaw puzzle. Mathematische Zeitschrift. 314(3), 37."},"quality_controlled":"1","das_tickbox":"1","publication":"Mathematische Zeitschrift","_id":"23149","researchdata_availability":"no","publication_identifier":{"issn":["0025-5874"],"eissn":["1432-1823"]},"external_id":{"arxiv":["2601.08774"]},"arxiv":1,"doi":"10.1007/s00209-026-04140-2","date_published":"2026-11-01T00:00:00Z","month":"11","type":"journal_article","date_updated":"2026-10-19T06:13:10Z","PlanS_conform":"1","date_created":"2026-10-18T22:01:50Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer","oa_version":"Published Version","article_type":"original","volume":314,"ddc":["510"],"file_date_updated":"2026-10-19T06:11:23Z","article_number":"37","department":[{"_id":"TiBr"}],"OA_type":"hybrid","author":[{"first_name":"Christian","id":"aefba9fc-4694-11f0-b73e-8bd408e8f734","full_name":"Bernert, Christian","last_name":"Bernert"},{"first_name":"Ulrich","last_name":"Derenthal","full_name":"Derenthal, Ulrich"},{"last_name":"Ortmann","full_name":"Ortmann, Judith","first_name":"Judith"},{"orcid":"0000-0001-7302-8256","id":"560601DA-8D36-11E9-A136-7AC1E5697425","first_name":"Florian Alexander","last_name":"Wilsch","full_name":"Wilsch, Florian Alexander"}],"article_processing_charge":"Yes (via OA deal)","oa":1,"scopus_import":"1","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1007/s00209-026-04140-2","intvolume":" 314","issue":"3"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-18T22:01:52Z","date_updated":"2026-10-19T07:25:01Z","volume":26,"oa_version":"Preprint","article_type":"original","publisher":"American Physical Society","scopus_import":"1","oa":1,"article_processing_charge":"No","department":[{"_id":"GeKa"},{"_id":"GradSch"}],"OA_type":"green","author":[{"last_name":"Tjøtta","full_name":"Tjøtta, Maxim","first_name":"Maxim"},{"last_name":"Shah","full_name":"Shah, Devashish C","orcid":"0009-0007-5829-7707","id":"de191434-4e7e-11ef-bf4b-9a056fc19fc3","first_name":"Devashish C"},{"last_name":"Modi","full_name":"Modi, Kanishk","id":"f05345fd-900f-11f1-bfd8-8c0b6eadcc7f","first_name":"Kanishk"},{"first_name":"Marco","id":"C0BB2FAC-D767-11E9-B658-BC13E6697425","full_name":"Valentini, Marco","last_name":"Valentini"},{"first_name":"Rubén","last_name":"Seoane Souto","full_name":"Seoane Souto, Rubén"},{"last_name":"Katsaros","full_name":"Katsaros, Georgios","orcid":"0000-0001-8342-202X","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios"},{"first_name":"Jeroen","full_name":"Danon, Jeroen","last_name":"Danon"}],"article_number":"044017","intvolume":" 26","issue":"4","project":[{"name":"Superconducting spin qubits in planar Ge","_id":"5b9e579c-ab3d-11f0-914f-88754c5b5a3f","grant_number":"PAT 7682124"}],"fulldoi":"https://doi.org/10.1103/d3gl-qntm","language":[{"iso":"eng"}],"dataavailabilitystatement":"The data that support the findings of this article are openly available at [10.5281/zenodo.22646275].","year":"2026","abstract":[{"text":"Extracting the current-phase relationship (CPR) of a single superconducting junction is challenging in practice and traditionally involves embedding the junction in a larger superconducting circuit containing SQUIDs and/or resonators. Applying ac driving to the junction has proven to be a viable and less invasive way to extract information about the few lowest harmonics of the CPR, by locating the integer and fractional Shapiro steps in the 𝐼𝑉-curve of the driven junction. Here, we present an alternative driving-based method that allows to extract the full harmonic content of a CPR in a relatively noninvasive way, by fitting the measured critical currents of the driven junction as a function of driving power. We test our method, both using numerical simulations and in experiments, and we show that it works accurately.","lang":"eng"}],"title":"Fast-driving spectroscopy of current-phase relationships of individual Josephson elements","status":"public","acknowledgement":"The authors thank Afonso Oliveira, Stefano Calcaterra, Daniel Chrastina, and Giovanni Isella for providing the Ge/SiGe heterostructure. This work was supported by the Research Council of Norway through its Centers of Excellence funding scheme, Project No. 262633, “QuSpin,” the FWF Project with DOI:10.55776/PAT7682124, OeAD “ISTA Austria: ISTernship Summer Programme, Non-EU countries” (Ref. No.: MPC-2025-00945), the Spanish Comunidad de Madrid (CM) “Talento Program” (Project No. 2022-T1/IND-24070), and the Spanish Ministry of Science, Innovation, and Universities through Grants No. CEX2024-001445-S (Severo Ochoa Centres of Excellence program) and No. PID2022-140552NA-I00, funded by MCIN/AEI/10.13039/501100011033.","OA_place":"repository","supplementarymaterial":"yes","_id":"23156","day":"01","citation":{"mla":"Tjøtta, Maxim, et al. “Fast-Driving Spectroscopy of Current-Phase Relationships of Individual Josephson Elements.” Physical Review Applied, vol. 26, no. 4, 044017, American Physical Society, 2026, doi:10.1103/d3gl-qntm.","chicago":"Tjøtta, Maxim, Devashish C Shah, Kanishk Modi, Marco Valentini, Rubén Seoane Souto, Georgios Katsaros, and Jeroen Danon. “Fast-Driving Spectroscopy of Current-Phase Relationships of Individual Josephson Elements.” Physical Review Applied. American Physical Society, 2026. https://doi.org/10.1103/d3gl-qntm.","ista":"Tjøtta M, Shah DC, Modi K, Valentini M, Seoane Souto R, Katsaros G, Danon J. 2026. Fast-driving spectroscopy of current-phase relationships of individual Josephson elements. Physical Review Applied. 26(4), 044017.","short":"M. Tjøtta, D.C. Shah, K. Modi, M. Valentini, R. Seoane Souto, G. Katsaros, J. Danon, Physical Review Applied 26 (2026).","ieee":"M. Tjøtta et al., “Fast-driving spectroscopy of current-phase relationships of individual Josephson elements,” Physical Review Applied, vol. 26, no. 4. American Physical Society, 2026.","ama":"Tjøtta M, Shah DC, Modi K, et al. Fast-driving spectroscopy of current-phase relationships of individual Josephson elements. Physical Review Applied. 2026;26(4). doi:10.1103/d3gl-qntm","apa":"Tjøtta, M., Shah, D. C., Modi, K., Valentini, M., Seoane Souto, R., Katsaros, G., & Danon, J. (2026). Fast-driving spectroscopy of current-phase relationships of individual Josephson elements. Physical Review Applied. American Physical Society. https://doi.org/10.1103/d3gl-qntm"},"quality_controlled":"1","publication":"Physical Review Applied","das_tickbox":"1","publication_status":"published","date_published":"2026-10-01T00:00:00Z","doi":"10.1103/d3gl-qntm","arxiv":1,"external_id":{"arxiv":["2511.14313"]},"publication_identifier":{"eissn":["2331-7019"]},"researchdata_availability":"yes","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2511.14313"}],"type":"journal_article","month":"10"},{"month":"02","type":"journal_article","external_id":{"arxiv":["2512.08427"]},"researchdata_availability":"no","publication_identifier":{"eissn":["2470-0029"],"issn":["2470-0010"]},"date_published":"2026-02-25T00:00:00Z","doi":"10.1103/p328-62sl","arxiv":1,"has_accepted_license":"1","publication_status":"published","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_size":3535182,"date_updated":"2026-10-19T08:06:17Z","access_level":"open_access","date_created":"2026-10-19T08:06:17Z","creator":"dernst","content_type":"application/pdf","relation":"main_file","checksum":"764bd6512975216dd63655da64ceeb95","success":1,"file_id":"23167","file_name":"2026_PhysicalReviewD_Park.pdf"}],"_id":"23159","day":"25","citation":{"chicago":"Park, Kevin S, Zoltán Haiman, Chengcheng Xin, Tzuken Shen, Ashley Villar, and Jordy Davelaar. “Self-Lensing Flares from Black Hole Binaries. V. Systematic Searches in LSST.” Physical Review D. American Physical Society, 2026. https://doi.org/10.1103/p328-62sl.","mla":"Park, Kevin S., et al. “Self-Lensing Flares from Black Hole Binaries. V. Systematic Searches in LSST.” Physical Review D, vol. 113, no. 4, 043055, American Physical Society, 2026, doi:10.1103/p328-62sl.","short":"K.S. Park, Z. Haiman, C. Xin, T. Shen, A. Villar, J. Davelaar, Physical Review D 113 (2026).","ista":"Park KS, Haiman Z, Xin C, Shen T, Villar A, Davelaar J. 2026. Self-lensing flares from black hole binaries. V. Systematic searches in LSST. Physical Review D. 113(4), 043055.","ama":"Park KS, Haiman Z, Xin C, Shen T, Villar A, Davelaar J. Self-lensing flares from black hole binaries. V. Systematic searches in LSST. Physical Review D. 2026;113(4). doi:10.1103/p328-62sl","ieee":"K. S. Park, Z. Haiman, C. Xin, T. Shen, A. Villar, and J. Davelaar, “Self-lensing flares from black hole binaries. V. Systematic searches in LSST,” Physical Review D, vol. 113, no. 4. American Physical Society, 2026.","apa":"Park, K. S., Haiman, Z., Xin, C., Shen, T., Villar, A., & Davelaar, J. (2026). Self-lensing flares from black hole binaries. V. Systematic searches in LSST. Physical Review D. American Physical Society. https://doi.org/10.1103/p328-62sl"},"quality_controlled":"1","publication":"Physical Review D","das_tickbox":"1","acknowledgement":"We acknowledge support by NASA Grants No. 80NSSC22K0822 and No. 80NSSC24K0440 (Z. H). V. A. V. acknowledges support through the David and Lucile Packard Foundation, National Science Foundation under No. PHY-2019786 (The NSF AI Institute for Artificial Intelligence and Fundamental Interactions, [63]), No. AST-2433718, No. AST-2407922 and No. AST-2406110, as well as an Aramont Fellowship for Emerging Science Research. J. D. acknowledges support by a joint Columbia/Flatiron Postdoctoral Fellowship. Research at the Flatiron Institute is supported by the Simons Foundation. This research was supported in part by the National Science Foundation under Grant No. NSF PHY-1748958 to the Kavli Institute for Theoretical Physics (KITP). This research has made use of NASA’s Astrophysics Data System. The authors acknowledge the Texas Advanced Computing Center (TACC) at The University of Texas at Austin for providing computational resources. V. A. V. acknowledges support through the David and Lucile Packard Foundation, National Science Foundation under No. AST-2433718, No. AST-2407922 and No. AST-2406110, as well as an Aramont Fellowship for Emerging Science Research. This work is supported by the National Science Foundation under Cooperative Agreement No. PHY-2019786 (The NSF AI Institute for Artificial Intelligence and Fundamental Interactions, [63]).","OA_place":"publisher","supplementarymaterial":"yes","dataavailabilitystatement":"The data are not publicly available. The data are available from the authors upon reasonable request.","year":"2026","abstract":[{"text":"The Vera C. Rubin Observatory has now seen first light, and over a 10 year duration, Legacy Survey of Space and Time (LSST) is projected to catalog tens of millions of quasars, many of which are expected to be associated with subparsec supermassive black hole binaries (SMBHBs). Out of these SMBHBs, up to thousands of relatively massive binary-quasars are expected to exhibit gravitational self-lensing flares (SLFs) that last for at least 20–30 days. We assess the effectiveness of the Lomb-Scargle (LS) periodogram and matched filters (MFs) as methods for systematic searches for these binaries, using toy-models of hydrodynamical, Doppler, and self-lensing variability from equal-mass, eccentric SMBHBs. We inject SLFs into random realizations of damped random walk (DRW) lightcurves, representing stochastic quasar variability, and compute the LS periodogram with and without the SLF. We find that periodograms of SLF+DRW light-curves do not have maximum peak heights that could not arise from DRW-only periodograms. On the other hand, the matched filter signal-to-noise ratio (SNR) can distinguish SLFs from noise even with LSST-like cadences and DRW noise. Furthermore, we develop a three-step procedure with matched filters, which can also recover injected binary parameters from these light-curves. We expect this method to be computationally efficient enough to be applicable to millions of quasar light-curves in LSST.","lang":"eng"}],"status":"public","title":"Self-lensing flares from black hole binaries. V. Systematic searches in LSST","language":[{"iso":"eng"}],"intvolume":" 113","issue":"4","fulldoi":"https://doi.org/10.1103/p328-62sl","article_number":"043055","oa":1,"scopus_import":"1","OA_type":"hybrid","article_processing_charge":"Yes (in subscription journal)","author":[{"full_name":"Park, Kevin S","last_name":"Park","first_name":"Kevin S","id":"c0a7603b-66e5-11f0-aaf9-b02edf8b2969"},{"id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","first_name":"Zoltán","orcid":"0000-0003-3633-5403","last_name":"Haiman","full_name":"Haiman, Zoltán"},{"last_name":"Xin","full_name":"Xin, Chengcheng","first_name":"Chengcheng"},{"last_name":"Shen","full_name":"Shen, Tzuken","first_name":"Tzuken"},{"first_name":"Ashley","full_name":"Villar, Ashley","last_name":"Villar"},{"last_name":"Davelaar","full_name":"Davelaar, Jordy","first_name":"Jordy"}],"department":[{"_id":"GradSch"},{"_id":"ZoHa"}],"oa_version":"Published Version","article_type":"original","publisher":"American Physical Society","ddc":["520"],"file_date_updated":"2026-10-19T08:06:17Z","volume":113,"PlanS_conform":"1","date_updated":"2026-10-19T08:08:21Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-18T22:01:53Z"},{"publication_identifier":{"eissn":["2168-8737"],"issn":["1050-5164"]},"researchdata_availability":"no","keyword":["Random regular graphs","coupling","contiguity","total variation distance","decomposition"],"external_id":{"arxiv":["2505.22875"]},"arxiv":1,"doi":"10.1214/26-AAP2345","date_published":"2026-10-01T00:00:00Z","month":"10","page":"4716-4738","type":"journal_article","supplementarymaterial":"no","acknowledgement":"We are grateful to Béla Bollobás, to Matthew Kwan and to Fabio\r\nToninelli for their helpful comments and suggestions, and to Nicholas Wormald for useful\r\nremarks on a preliminary version of this work and pointing us towards the reference [29].\r\nThe authors would also like to thank several anonymous referees for many useful suggestions,\r\nincluding pointing out that Lemma 2.10 already appeared in [11].\r\nPart of this research was done during a visit of the fourth author to IST Austria. We thank\r\nIST Austria for its hospitality.\r\nFor open access purposes, the authors have applied a CC BY public copyright license to\r\nany author accepted manuscript version arising from this submission. L. Hollom was supported by the Internal Graduate Studentship of Trinity College, Cambridge.\r\nL. Lichev was supported by the Austrian Science Fund (FWF) grant No. 10.55776/ESP624.\r\nA. Mond was supported by UK Research and Innovation grant MR/W007320/2. Wang was\r\nsupported by the ERC Starting Grant “RANDSTRUCT” No. 101076777.","OA_place":"publisher","title":"Monotonicity and decompositions of random regular graphs","status":"public","year":"2026","abstract":[{"lang":"eng","text":"In this work we establish several monotonicity and decomposition results in the framework of random regular graphs. Among other results, we\r\nshow that, for a wide range of parameters d1 ≤ d2, there exists a coupling of\r\nG(n,d1) and G(n,d2) satisfying that G(n,d1) ⊆ G(n,d2) with high probability, confirming a conjecture of Gao, Isaev and McKay in a new regime.\r\nOur contributions include new tools for analysing contiguity and total variation distance between random regular graph models, a novel procedure for\r\ngenerating unions of random edge-disjoint perfect matchings, and refined estimates of Gao’s bounds on the number of perfect matchings in random regular graphs. In addition, we make progress towards another conjecture of Isaev,\r\nMcKay, Southwell and Zhukovskii."}],"file":[{"content_type":"application/pdf","creator":"dernst","date_created":"2026-10-19T07:33:58Z","access_level":"open_access","date_updated":"2026-10-19T07:33:58Z","file_size":320593,"file_name":"2026_AnnalsAppliedProbability_Hollom.pdf","file_id":"23165","success":1,"checksum":"46101e61d29cf40f0a204801d15a848f","relation":"main_file"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","publication_status":"published","das_tickbox":"0","quality_controlled":"1","publication":"Annals of Applied Probability","day":"01","citation":{"chicago":"Hollom, Lawrence, Lyuben Lichev, Adva Mond, Julien Portier, and Yiting Wang. “Monotonicity and Decompositions of Random Regular Graphs.” Annals of Applied Probability. Institute of Mathematical Statistics, 2026. https://doi.org/10.1214/26-AAP2345.","mla":"Hollom, Lawrence, et al. “Monotonicity and Decompositions of Random Regular Graphs.” Annals of Applied Probability, vol. 36, no. 5, Institute of Mathematical Statistics, 2026, pp. 4716–38, doi:10.1214/26-AAP2345.","ista":"Hollom L, Lichev L, Mond A, Portier J, Wang Y. 2026. Monotonicity and decompositions of random regular graphs. Annals of Applied Probability. 36(5), 4716–4738.","short":"L. Hollom, L. Lichev, A. Mond, J. Portier, Y. Wang, Annals of Applied Probability 36 (2026) 4716–4738.","ieee":"L. Hollom, L. Lichev, A. Mond, J. Portier, and Y. Wang, “Monotonicity and decompositions of random regular graphs,” Annals of Applied Probability, vol. 36, no. 5. Institute of Mathematical Statistics, pp. 4716–4738, 2026.","ama":"Hollom L, Lichev L, Mond A, Portier J, Wang Y. Monotonicity and decompositions of random regular graphs. Annals of Applied Probability. 2026;36(5):4716-4738. doi:10.1214/26-AAP2345","apa":"Hollom, L., Lichev, L., Mond, A., Portier, J., & Wang, Y. (2026). Monotonicity and decompositions of random regular graphs. Annals of Applied Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/26-AAP2345"},"_id":"23155","mathsc":["05C80"],"author":[{"full_name":"Hollom, Lawrence","last_name":"Hollom","first_name":"Lawrence"},{"last_name":"Lichev","full_name":"Lichev, Lyuben","id":"9aa8388e-d003-11ee-8458-c4c1d7447977","first_name":"Lyuben"},{"full_name":"Mond, Adva","last_name":"Mond","first_name":"Adva"},{"first_name":"Julien","full_name":"Portier, Julien","last_name":"Portier"},{"id":"1917d194-076e-11ed-97cd-837255f88785","first_name":"Yiting","last_name":"Wang","full_name":"Wang, Yiting"}],"OA_type":"hybrid","article_processing_charge":"Yes (in subscription journal)","department":[{"_id":"MaKw"},{"_id":"GradSch"}],"scopus_import":"1","oa":1,"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1214/26-AAP2345","project":[{"name":"Randomness and structure in combinatorics","_id":"bd95085b-d553-11ed-ba76-e55d3349be45","grant_number":"101076777"},{"name":"THRESHOLDS IN SEMI-RANDOM PROCESSES AND GRAPH EMBEDDINGS","_id":"e19fef4c-1f3d-11f0-ac04-b8b1af6886d8","grant_number":"E624"}],"intvolume":" 36","issue":"5","date_updated":"2026-10-19T07:39:17Z","PlanS_conform":"1","date_created":"2026-10-18T22:01:52Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Institute of Mathematical Statistics","article_type":"original","oa_version":"Published Version","volume":36,"file_date_updated":"2026-10-19T07:33:58Z","ddc":["500"]},{"oa":1,"scopus_import":"1","OA_type":"gold","author":[{"full_name":"Wu, Jiaojiao","last_name":"Wu","first_name":"Jiaojiao"},{"last_name":"Corvaglia","full_name":"Corvaglia, Valentina","first_name":"Valentina"},{"first_name":"Tulika","full_name":"Chakrabortty, Tulika","last_name":"Chakrabortty"},{"id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","first_name":"Pradeep K","orcid":"0000-0001-5996-956X","last_name":"Mandal","full_name":"Mandal, Pradeep K"},{"first_name":"Ivan","full_name":"Huc, Ivan","last_name":"Huc"}],"department":[{"_id":"LifeSc"}],"article_processing_charge":"Yes","issue":"32","intvolume":" 17","fulldoi":"https://doi.org/10.1039/d6sc00798h","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-06-16T08:04:15Z","PlanS_conform":"1","date_updated":"2026-10-19T08:35:08Z","ddc":["540"],"file_date_updated":"2026-10-19T08:32:00Z","volume":17,"article_type":"original","oa_version":"Published Version","publisher":"Royal Society of Chemistry","pmid":1,"date_published":"2026-08-19T00:00:00Z","doi":"10.1039/d6sc00798h","external_id":{"pmid":["42388815"]},"publication_identifier":{"eissn":["2041-6539"],"issn":["2041-6520"]},"researchdata_availability":"yes","type":"journal_article","page":"15479–15489","month":"08","year":"2026","abstract":[{"text":"Single stranded helically folded aromatic oligoamides bearing anionic phosphonate side chains have been shown to bind to some DNA-binding proteins better than DNA itself. However, these DNA mimic foldamers have until now mainly consisted of a single repeat motif, like a poly(dA:dT) DNA duplex, and contained limited sequence information. Here, we introduce new monomers designed to display different chemical functionalities in the major groove of the DNA mimics. Four new Fmoc-protected amino acid monomers have been synthesized and incorporated into oligomers. Sixteen foldamer sequences were prepared on solid phase. Their conformation in solution and in the solid state and their conformational dynamics were investigated using NMR, circular dichroism, molecular modeling, and X-ray crystallography. The results show that three of four new monomers behaved as designed, and that their introduction enhances the conformational dynamics of the DNA mimic foldamers. In a fourth case, conformational behavior proved to be more complex than expected. The modified sequences retained an ability to bind to bacterial histone-like protein HU. These results showcase design strategies to manipulate large molecular biomimetics where not only side chains but also main chain components are varied. The new monomers pave the way to complex DNA mimic foldamer sequences targeting proteins that recognize sequence-selective DNA-binding proteins such as transcription factors or restriction enzymes.","lang":"eng"}],"dataavailabilitystatement":"CCDC 2514117, 2514118, 2286782 and 2478322 (compound 1, compound 1d, oligomer 5, and oligomer 6, respectively) contain the supplementary crystallographic data for this paper.54a–d \r\n\r\nThe supporting data have been provided as part of the supplementary information (SI). Supplementary information: SI figures, detailed experimental protocols, crystallographic studies, and characterisation of new compounds. See DOI: https://doi.org/10.1039/d6sc00798h.","status":"public","title":"Tailoring the major groove of DNA mimic foldamers","OA_place":"publisher","acknowledgement":"We acknowledge financial support from the European Research Council (ERC) under the European Union's Horizon Europe Framework Programme (grant agreement no. ERC-2021-ADG-320892) and from the China Scholarship Council (CSC, predoctoral fellowship to J. W.). We thank L. Allmendinger for assistance with NMR measurements, P. Mayer for his assistance in solving the crystal structures of 1 and 1d, L. Bodero for assistance with automated solid-phase synthesis, M. Rogovoi for providing monomer precursors, and M. Loos for the purification and analysis of compounds 15a–19a. We thank M. Soler-Lopez (ID23-1, ESRF, Grenoble) and I. Bento (EMBL P13, Petra III, DESY, Hamburg) for assistance during data collection at the synchrotron beamlines.","DOAJ_listed":"1","supplementarymaterial":"yes","_id":"22012","das_tickbox":"1","quality_controlled":"1","publication":"Chemical Science","day":"19","citation":{"apa":"Wu, J., Corvaglia, V., Chakrabortty, T., Mandal, P. K., & Huc, I. (2026). Tailoring the major groove of DNA mimic foldamers. Chemical Science. Royal Society of Chemistry. https://doi.org/10.1039/d6sc00798h","ama":"Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. Tailoring the major groove of DNA mimic foldamers. Chemical Science. 2026;17(32):15479–15489. doi:10.1039/d6sc00798h","ieee":"J. Wu, V. Corvaglia, T. Chakrabortty, P. K. Mandal, and I. Huc, “Tailoring the major groove of DNA mimic foldamers,” Chemical Science, vol. 17, no. 32. Royal Society of Chemistry, pp. 15479–15489, 2026.","short":"J. Wu, V. Corvaglia, T. Chakrabortty, P.K. Mandal, I. Huc, Chemical Science 17 (2026) 15479–15489.","ista":"Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. 2026. Tailoring the major groove of DNA mimic foldamers. Chemical Science. 17(32), 15479–15489.","chicago":"Wu, Jiaojiao, Valentina Corvaglia, Tulika Chakrabortty, Pradeep K Mandal, and Ivan Huc. “Tailoring the Major Groove of DNA Mimic Foldamers.” Chemical Science. Royal Society of Chemistry, 2026. https://doi.org/10.1039/d6sc00798h.","mla":"Wu, Jiaojiao, et al. “Tailoring the Major Groove of DNA Mimic Foldamers.” Chemical Science, vol. 17, no. 32, Royal Society of Chemistry, 2026, pp. 15479–15489, doi:10.1039/d6sc00798h."},"publication_status":"published","has_accepted_license":"1","file":[{"file_name":"2026_ChemicalScience_Wu.pdf","success":1,"file_id":"23169","relation":"main_file","checksum":"fee032060eb71cba73afa8e301b9ee94","creator":"dernst","content_type":"application/pdf","access_level":"open_access","date_created":"2026-10-19T08:32:00Z","file_size":1361818,"date_updated":"2026-10-19T08:32:00Z"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"}},{"date_created":"2026-10-18T22:01:52Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-10-19T07:55:13Z","PlanS_conform":"1","volume":65,"ddc":["500"],"file_date_updated":"2026-10-19T07:53:14Z","publisher":"Springer","pmid":1,"oa_version":"Published Version","article_type":"original","author":[{"full_name":"Brooks, Morris","last_name":"Brooks","first_name":"Morris","id":"B7ECF9FC-AA38-11E9-AC9A-0930E6697425","orcid":"0000-0002-6249-0928"},{"full_name":"Mitrouskas, David Johannes","last_name":"Mitrouskas","first_name":"David Johannes","id":"cbddacee-2b11-11eb-a02e-a2e14d04e52d"}],"article_processing_charge":"Yes (via OA deal)","OA_type":"hybrid","department":[{"_id":"RoSe"}],"oa":1,"scopus_import":"1","mathsc":["81Q05"],"article_number":"270","fulldoi":"https://doi.org/10.1007/s00526-026-03436-9","intvolume":" 65","issue":"10","language":[{"iso":"eng"}],"status":"public","title":"Adiabatic Klein–Gordon dynamics for the renormalized Nelson model","dataavailabilitystatement":"No data are associated with this article.","year":"2026","abstract":[{"lang":"eng","text":"We study the renormalized Nelson model in a semiclassical regime where the field becomes\r\nclassical while the particle remains quantum. The degree of classicality is measured by a\r\nsmall parameter ε << 1. In this scaling the particle evolves on microscopic times, whereas\r\nthe field exhibits nontrivial dynamics only on the macroscopic scale t = O(ε^−2). The natural\r\nsemiclassical model is the coupled Schrödinger–Klein–Gordon (SKG) system, which\r\nencodes the time-scale separation through an explicit ε-dependence. Based on this scale separation\r\nin SKG, we apply the adiabatic principle to derive a new PDE for the classical field,\r\nthe ε-free adiabatic Klein–Gordon (aKG) equation, where the field is driven by the instantaneous\r\nground state of the particle. Our main result is a norm approximation of the Nelson\r\ndynamics by the aKGsolution corrected by a quasi-free fluctuation dynamics around the classical\r\nfield, generated by a renormalized Bogoliubov–Nelson Hamiltonian. As a corollary, we\r\nobtain convergence of the reduced one-body densities for both subsystems, where the fluctuation\r\ncorrection vanishes, thereby justifying aKG as a semiclassical Born–Oppenheimer\r\ntype approximation of the renormalized Nelson model."}],"supplementarymaterial":"yes","acknowledgement":"Morris Brooks gratefully acknowledges support from the ERC Advanced Grant CLaQS, grant agreement No. 834782. Open access funding provided by University of Zurich.","OA_place":"publisher","citation":{"mla":"Brooks, Morris, and David Johannes Mitrouskas. “Adiabatic Klein–Gordon Dynamics for the Renormalized Nelson Model.” Calculus of Variations and Partial Differential Equations, vol. 65, no. 10, 270, Springer, 2026, doi:10.1007/s00526-026-03436-9.","chicago":"Brooks, Morris, and David Johannes Mitrouskas. “Adiabatic Klein–Gordon Dynamics for the Renormalized Nelson Model.” Calculus of Variations and Partial Differential Equations. Springer, 2026. https://doi.org/10.1007/s00526-026-03436-9.","ista":"Brooks M, Mitrouskas DJ. 2026. Adiabatic Klein–Gordon dynamics for the renormalized Nelson model. Calculus of Variations and Partial Differential Equations. 65(10), 270.","short":"M. Brooks, D.J. Mitrouskas, Calculus of Variations and Partial Differential Equations 65 (2026).","ama":"Brooks M, Mitrouskas DJ. Adiabatic Klein–Gordon dynamics for the renormalized Nelson model. Calculus of Variations and Partial Differential Equations. 2026;65(10). doi:10.1007/s00526-026-03436-9","ieee":"M. Brooks and D. J. Mitrouskas, “Adiabatic Klein–Gordon dynamics for the renormalized Nelson model,” Calculus of Variations and Partial Differential Equations, vol. 65, no. 10. Springer, 2026.","apa":"Brooks, M., & Mitrouskas, D. J. (2026). Adiabatic Klein–Gordon dynamics for the renormalized Nelson model. Calculus of Variations and Partial Differential Equations. Springer. https://doi.org/10.1007/s00526-026-03436-9"},"day":"01","publication":"Calculus of Variations and Partial Differential Equations","quality_controlled":"1","das_tickbox":"1","_id":"23153","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"checksum":"406bc9d144c35c9485d277c842d38c36","relation":"main_file","file_id":"23166","success":1,"file_name":"2026_CalculusVariations_Brooks.pdf","date_updated":"2026-10-19T07:53:14Z","file_size":905142,"date_created":"2026-10-19T07:53:14Z","access_level":"open_access","creator":"dernst","content_type":"application/pdf"}],"has_accepted_license":"1","publication_status":"published","arxiv":1,"date_published":"2026-10-01T00:00:00Z","doi":"10.1007/s00526-026-03436-9","researchdata_availability":"no","publication_identifier":{"eissn":["1432-0835"],"issn":["0944-2669"]},"external_id":{"pmid":["42865432"],"arxiv":["2509.14226"]},"type":"journal_article","month":"10"},{"acknowledgement":"This publication is based upon work from the Ethics Crossover Group within the cost Action improve (“3Rs concepts to improve the quality of biomedical science”), ca21139, supported by cost (European Cooperation in Science and Technology).\r\nWe sincerely thank Nuno Franco for critical reviewing the manuscript.\r\nWe acknowledge support by Open Access Publishing Fund of Karl Landsteiner University, Krems, Austria.","OA_place":"publisher","supplementarymaterial":"no","year":"2026","abstract":[{"lang":"eng","text":"The concept of Culture of Care fosters a research environment where lab animals and humans are cared for and respected. Several aspects, such as perception of suffering, time, perceived value of an animal, potential benefits of the research, and public opinion, might influence care for animals. The European Directive 2010/63/EU on the protection of animals used for scientific purposes has represented an advance in animal welfare standards and care. However, the question of how we care about animals in practice, and of why this debate is important to reflect on still exist. Therefore, we draw upon the case study of laboratory non-human primates, to illustrate how these tensions go from theory to practice. It illustrates the conflicts and emotions, by exposing the limitations of the standards and norms in the field. Debating care requires a more comprehensive notion of care, one that goes beyond normative decisions to enable care in practice."}],"title":"How we care about laboratory animals: Acknowledging differences towards a more comprehensive concept of caring","status":"public","has_accepted_license":"1","publication_status":"published","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"creator":"dernst","content_type":"application/pdf","access_level":"open_access","date_created":"2026-10-19T08:25:17Z","file_size":464277,"date_updated":"2026-10-19T08:25:17Z","file_name":"2026_JourAppliedAnimalEthicsResearch_Schober.pdf","success":1,"file_id":"23168","relation":"main_file","checksum":"a148db5e47af7cbfccaecf8cec0beff6"}],"_id":"23157","day":"01","citation":{"ama":"Schober S, Vitale A, Riso B. How we care about laboratory animals: Acknowledging differences towards a more comprehensive concept of caring. Journal of Applied Animal Ethics Research. 2026;8(1):88-104. doi:10.1163/25889567-bja10078","ieee":"S. Schober, A. Vitale, and B. Riso, “How we care about laboratory animals: Acknowledging differences towards a more comprehensive concept of caring,” Journal of Applied Animal Ethics Research, vol. 8, no. 1. Brill Academic Publishers, pp. 88–104, 2026.","apa":"Schober, S., Vitale, A., & Riso, B. (2026). How we care about laboratory animals: Acknowledging differences towards a more comprehensive concept of caring. Journal of Applied Animal Ethics Research. Brill Academic Publishers. https://doi.org/10.1163/25889567-bja10078","mla":"Schober, Sophie, et al. “How We Care about Laboratory Animals: Acknowledging Differences towards a More Comprehensive Concept of Caring.” Journal of Applied Animal Ethics Research, vol. 8, no. 1, Brill Academic Publishers, 2026, pp. 88–104, doi:10.1163/25889567-bja10078.","chicago":"Schober, Sophie, Augusto Vitale, and Brigida Riso. “How We Care about Laboratory Animals: Acknowledging Differences towards a More Comprehensive Concept of Caring.” Journal of Applied Animal Ethics Research. Brill Academic Publishers, 2026. https://doi.org/10.1163/25889567-bja10078.","ista":"Schober S, Vitale A, Riso B. 2026. How we care about laboratory animals: Acknowledging differences towards a more comprehensive concept of caring. Journal of Applied Animal Ethics Research. 8(1), 88–104.","short":"S. Schober, A. Vitale, B. Riso, Journal of Applied Animal Ethics Research 8 (2026) 88–104."},"das_tickbox":"0","publication":"Journal of Applied Animal Ethics Research","quality_controlled":"1","keyword":["culture of care","culture of care in practice","lab animals","interspecies relationships"],"publication_identifier":{"eissn":["2588-9567"],"issn":["2588-9559"]},"researchdata_availability":"no","doi":"10.1163/25889567-bja10078","date_published":"2026-09-01T00:00:00Z","month":"09","type":"journal_article","page":"88-104","PlanS_conform":"1","date_updated":"2026-10-19T08:28:37Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-18T22:01:53Z","oa_version":"Published Version","article_type":"original","publisher":"Brill Academic Publishers","file_date_updated":"2026-10-19T08:25:17Z","ddc":["570"],"volume":8,"oa":1,"scopus_import":"1","article_processing_charge":"Yes (via OA deal)","OA_type":"hybrid","department":[{"_id":"PreCl"}],"author":[{"id":"80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8","first_name":"Sophie","last_name":"Schober","full_name":"Schober, Sophie"},{"first_name":"Augusto","full_name":"Vitale, Augusto","last_name":"Vitale"},{"first_name":"Brigida","last_name":"Riso","full_name":"Riso, Brigida"}],"language":[{"iso":"eng"}],"issue":"1","intvolume":" 8","fulldoi":"https://doi.org/10.1163/25889567-bja10078"},{"_id":"23158","das_tickbox":"1","publication":"Discrete and Computational Geometry","quality_controlled":"1","citation":{"apa":"Hollom, L., Lichev, L., Mond, A., & Portier, J. (2026). A note on high-dimensional discrepancy of subtrees. Discrete and Computational Geometry. Springer. https://doi.org/10.1007/s00454-025-00790-x","ama":"Hollom L, Lichev L, Mond A, Portier J. A note on high-dimensional discrepancy of subtrees. Discrete and Computational Geometry. 2026. doi:10.1007/s00454-025-00790-x","ieee":"L. Hollom, L. Lichev, A. Mond, and J. Portier, “A note on high-dimensional discrepancy of subtrees,” Discrete and Computational Geometry. Springer, 2026.","ista":"Hollom L, Lichev L, Mond A, Portier J. 2026. A note on high-dimensional discrepancy of subtrees. Discrete and Computational Geometry.","short":"L. Hollom, L. Lichev, A. Mond, J. Portier, Discrete and Computational Geometry (2026).","mla":"Hollom, Lawrence, et al. “A Note on High-Dimensional Discrepancy of Subtrees.” Discrete and Computational Geometry, Springer, 2026, doi:10.1007/s00454-025-00790-x.","chicago":"Hollom, Lawrence, Lyuben Lichev, Adva Mond, and Julien Portier. “A Note on High-Dimensional Discrepancy of Subtrees.” Discrete and Computational Geometry. Springer, 2026. https://doi.org/10.1007/s00454-025-00790-x."},"day":"09","publication_status":"epub_ahead","abstract":[{"text":"For a tree T and a function f:E(T)→Sd, the imbalance of a subtree T′⊆T is given by |∑e∈E(T′)f(e)|. The d-dimensional discrepancy of the tree T is the minimum, over all functions f as above, of the maximum imbalance of a subtree of T. We prove tight asymptotic bounds for the discrepancy of a tree T, confirming a conjecture of Krishna, Michaeli, Sarantis, Wang and Wang. We also settle a related conjecture on oriented discrepancy of subtrees by the same authors.","lang":"eng"}],"year":"2026","dataavailabilitystatement":"Data sharing not applicable to this article as no datasets were generated or analysed during the current study.","title":"A note on high-dimensional discrepancy of subtrees","status":"public","acknowledgement":"The authors would like to thank both Béla Bollobás and the anonymous reviewer for their careful readings of the manuscript and for their valuable comments. The first author was funded by Trinity College, Cambridge. The second author was funded in whole or in part by the Austrian Science Fund (FWF) 10.55776/ESP624. The third author was supported by UK Research and Innovation grant MR/W007320/2. The fourth author was funded by EPSRC (Engineering and Physical Sciences Research Council) and by the Cambridge Commonwealth, European and International Trust.","OA_place":"repository","supplementarymaterial":"no","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2412.04170"}],"month":"10","doi":"10.1007/s00454-025-00790-x","date_published":"2026-10-09T00:00:00Z","arxiv":1,"external_id":{"arxiv":["2412.04170"]},"keyword":["Trees","High-dimensional discrepancy","Oriented discrepancy"],"publication_identifier":{"eissn":["1432-0444"],"issn":["0179-5376"]},"researchdata_availability":"no","article_type":"original","oa_version":"Preprint","publisher":"Springer","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-18T22:01:53Z","date_updated":"2026-10-19T08:20:42Z","fulldoi":"https://doi.org/10.1007/s00454-025-00790-x","project":[{"grant_number":"E624","_id":"e19fef4c-1f3d-11f0-ac04-b8b1af6886d8","name":"THRESHOLDS IN SEMI-RANDOM PROCESSES AND GRAPH EMBEDDINGS"}],"language":[{"iso":"eng"}],"scopus_import":"1","oa":1,"author":[{"first_name":"Lawrence","last_name":"Hollom","full_name":"Hollom, Lawrence"},{"first_name":"Lyuben","id":"9aa8388e-d003-11ee-8458-c4c1d7447977","full_name":"Lichev, Lyuben","last_name":"Lichev"},{"full_name":"Mond, Adva","last_name":"Mond","first_name":"Adva"},{"last_name":"Portier","full_name":"Portier, Julien","first_name":"Julien"}],"article_processing_charge":"No","department":[{"_id":"MaKw"}],"OA_type":"green","mathsc":["05C05","05C35","11K38"]},{"article_processing_charge":"Yes (via OA deal)","department":[{"_id":"MiSi"},{"_id":"Bio"}],"author":[{"full_name":"Radler, Philipp","last_name":"Radler","orcid":"0000-0001-9198-2182 ","first_name":"Philipp","id":"40136C2A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Viehboeck, Tobias","last_name":"Viehboeck","first_name":"Tobias"},{"first_name":"Zhen-Hao","last_name":"Luo","full_name":"Luo, Zhen-Hao"},{"full_name":"Maslać, Nevena","last_name":"Maslać","first_name":"Nevena"},{"last_name":"Schmidt","full_name":"Schmidt, Katharina","first_name":"Katharina"},{"full_name":"Hauschild, Robert","last_name":"Hauschild","orcid":"0000-0001-9843-3522","first_name":"Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Masaru K.","full_name":"Nobu, Masaru K.","last_name":"Nobu"},{"first_name":"Silvia","full_name":"Bulgheresi, Silvia","last_name":"Bulgheresi"},{"last_name":"Stradal","full_name":"Stradal, Theresia E. B.","first_name":"Theresia E. B."},{"first_name":"Klemens","full_name":"Rottner, Klemens","last_name":"Rottner"},{"first_name":"Hiroyuki","last_name":"Imachi","full_name":"Imachi, Hiroyuki"},{"last_name":"Sixt","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","orcid":"0000-0002-6620-9179"},{"first_name":"Christa","last_name":"Schleper","full_name":"Schleper, Christa"}],"OA_type":"hybrid","acknowledged_ssus":[{"_id":"Bio"}],"scopus_import":"1","oa":1,"fulldoi":"https://doi.org/10.1038/s41586-026-11063-9","project":[{"grant_number":"101071793","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces","_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd"},{"grant_number":"CZI01","_id":"c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473","name":"Tools for automation and feedback microscopy"}],"language":[{"iso":"eng"}],"date_created":"2026-10-19T09:26:53Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-10-19T09:40:50Z","PlanS_conform":"1","ddc":["570"],"publisher":"Springer Nature","pmid":1,"oa_version":"Published Version","article_type":"original","doi":"10.1038/s41586-026-11063-9","date_published":"2026-09-30T00:00:00Z","researchdata_availability":"yes","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"external_id":{"pmid":["42816618"]},"main_file_link":[{"url":"https://doi.org/10.1038/s41586-026-11063-9","open_access":"1"}],"type":"journal_article","month":"09","title":"Dynamic protrusions mediate crawling motility in Asgard archaea","status":"public","dataavailabilitystatement":"The plots in this manuscript were created using Jupyter Notebook; the source data for all figures have been provided in data source tables. Microscopy raw data for supplementary videos, the Jupyter notebooks to generate the plots and the raw files for the structural phylogenetic analysis are available at https://doi.org/10.6084/m9.figshare.30676367. The remaining raw microscopy data generated for this manuscript are available from https://www.ebi.ac.uk/biostudies/bioimages/studies/S-BIAD3928. The mass spectrometry proteomics data from the Co-IP experiments have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository79 and are available at https://www.ebi.ac.uk/pride/archive/projects/PXD068820. The mass spectrometry proteomics data of the proteome analysis is available at https://www.ebi.ac.uk/pride/archive/projects/PXD074767. Source data are provided with this paper.","year":"2026","abstract":[{"text":"Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion and spatially organized signalling pathways1,2. Asgard archaea, which are considered the closest known prokaryotic relatives of eukaryotes, potentially encode these functions within their large set of ‘eukaryotic signature proteins’3,4,5,6. The few cultivated members show a complex cell morphology, consisting of a central cell body from which several protrusions extend, filled with an actin-based cytoskeleton7,8. Here, live-cell microscopy of two organisms of the Lokiarchaea and Hodarchaea lineages7,9 showed that they dynamically and greatly change their cell shape on a minute time scale and grow and retract their extensive protrusions with a speed of 1.5–4.8 µm min−1, respectively. After adhering to a glass surface, cells use their protrusions to undergo active crawling motion. In the presence of selected actin inhibitors, however, the observed dynamics were arrested, suggesting a central role of actin in these processes. The observed cellular plasticity and motility are unique features among prokaryotes and might have been crucial for the emergence of the first eukaryotic cells that are thought to have formed through the association of a member of the Asgard archaea and an α-proteobacterium, the ancestor of mitochondria.","lang":"eng"}],"supplementarymaterial":"yes","acknowledgement":"This work would not have been possible without the technical support in cultivation from K. Hager, F. Baraket, A. Malits and S. Harrer. We thank the Imaging and Optics Facility (IOF) at ISTA for their help in setting up the anaerobic environment during imaging and the Cell Imaging & Ultrastructure Research (CIUS) facility at the University of Vienna for their support. Proteomics analyses were performed by the Mass Spectrometry Facility at Max Perutz Labs using the VBCF instrument pool. We also thank P. Klahn (University of Gothenburg, Sweden), M. Stadler and members of his department (HZI Braunschweig) as well as R. Cox (LUH Hannover) for providing different cytochalasans and P. Bieling (King’s College London) for discussion. Most of this work was funded by the Austrian Science Fund (FWF) with grant DOI 10.55776/Z437 (available at https://doi.org/10.55776/Z437) and further supported by an emerging field grant with grant DOI 10.55776/EFP25 (available at https://doi.org/10.55776/EFP25) to C.S. For open access purposes, the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission. This work was further supported by a European Research Council grant ERC-SyG (101071793) to M.S., by the German Research Council through the CytoLabs consortium (Research Unit 5170 to K.R. and T.E.B.S.), by the Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research 22H04985 to H.I. and M.N. Furthermore, R.H. was supported by CZI grant DAF2020-225401 and a grant (https://doi.org/10.37921/120055ratwvi) from the Chan Zuckerberg Initiative DAF. Open access funding provided by University of Vienna.","OA_place":"publisher","day":"30","citation":{"mla":"Radler, Philipp, et al. “Dynamic Protrusions Mediate Crawling Motility in Asgard Archaea.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-11063-9.","chicago":"Radler, Philipp, Tobias Viehboeck, Zhen-Hao Luo, Nevena Maslać, Katharina Schmidt, Robert Hauschild, Masaru K. Nobu, et al. “Dynamic Protrusions Mediate Crawling Motility in Asgard Archaea.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-11063-9.","short":"P. Radler, T. Viehboeck, Z.-H. Luo, N. Maslać, K. Schmidt, R. Hauschild, M.K. Nobu, S. Bulgheresi, T.E.B. Stradal, K. Rottner, H. Imachi, M.K. Sixt, C. Schleper, Nature (2026).","ista":"Radler P, Viehboeck T, Luo Z-H, Maslać N, Schmidt K, Hauschild R, Nobu MK, Bulgheresi S, Stradal TEB, Rottner K, Imachi H, Sixt MK, Schleper C. 2026. Dynamic protrusions mediate crawling motility in Asgard archaea. Nature.","ama":"Radler P, Viehboeck T, Luo Z-H, et al. Dynamic protrusions mediate crawling motility in Asgard archaea. Nature. 2026. doi:10.1038/s41586-026-11063-9","ieee":"P. Radler et al., “Dynamic protrusions mediate crawling motility in Asgard archaea,” Nature. Springer Nature, 2026.","apa":"Radler, P., Viehboeck, T., Luo, Z.-H., Maslać, N., Schmidt, K., Hauschild, R., … Schleper, C. (2026). Dynamic protrusions mediate crawling motility in Asgard archaea. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-11063-9"},"publication":"Nature","das_tickbox":"1","quality_controlled":"1","_id":"23171","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_status":"epub_ahead","has_accepted_license":"1"},{"author":[{"first_name":"Cedric","full_name":"Richter, Cedric","last_name":"Richter"},{"first_name":"Marek","id":"87e34708-d6c6-11ec-9f5b-9391e7be2463","full_name":"Chalupa, Marek","last_name":"Chalupa"},{"full_name":"Jakobs, Marie Christine","last_name":"Jakobs","first_name":"Marie Christine"},{"first_name":"Heike","full_name":"Wehrheim, Heike","last_name":"Wehrheim"}],"department":[{"_id":"ToHe"}],"article_processing_charge":"No","OA_type":"hybrid","oa":1,"scopus_import":"1","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.18420/se2026_45","date_updated":"2026-10-19T08:49:32Z","date_created":"2026-08-02T22:01:54Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Gesellschaft für Informatik","oa_version":"Published Version","volume":"P-377","file_date_updated":"2026-10-19T08:39:37Z","ddc":["000"],"researchdata_availability":"yes","publication_identifier":{"eissn":["1617-5468"]},"keyword":["Software Verification","Cooperation","Program Decomposition"],"date_published":"2026-03-01T00:00:00Z","doi":"10.18420/se2026_45","month":"03","page":"41-42","type":"conference","supplementarymaterial":"no","conference":{"start_date":"2026-02-23","location":"Bonn, Switzerland","name":"SE: Software Engineering","end_date":"2026-02-27"},"OA_place":"publisher","status":"public","title":"Off-the-Shelf cooperative software verification by splitting programs dynamically","dataavailabilitystatement":"All our implementations and data are archived and available at Zenodo5\r\nand are evaluated as an artifact in the ICSE 2025 artifact evaluation. Furthermore, our\r\napproach is integrated into the software verifier Bubaak [CR25] which we submitted as\r\npart of our contribution to SV-COMP 2025.","license":"https://creativecommons.org/licenses/by-sa/4.0/","abstract":[{"lang":"eng","text":"Cooperative software verification aims at improving the effectiveness and efficiency of software verification by enabling multiple verification tools to work together. Existing cooperative verification schemes, however, typically require specialized interfaces or tight integration, limiting their practical applicability. In our International Conference on Software Engineering (ICSE) 2025 publication, we introduce dynamic program splitting – a novel approach that enables cooperation between off-the-shelf verification tools without requiring any modifications. The key idea is to probe verification tools on a given verification task under a time limit and split tasks dynamically that cannot be verified under the given time constraints. The process continues recursively, incrementally identifying program parts that are particularly hard for the given verifier. The remaining unverified parts are provided to a second verifier, allowing to leverage the complementary strengths of different tools. Our evaluation on SV-COMP benchmarks demonstrates that cooperation through dynamic program splitting enables the verification of tasks that none of the individual verifiers can solve on their own."}],"year":"2026","tmp":{"image":"/images/cc_by_sa.png","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","short":"CC BY-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode"},"file":[{"file_id":"23170","success":1,"file_name":"2026_LNI_Richter.pdf","checksum":"3371c63711ed26efa41744834d337d28","relation":"main_file","date_created":"2026-10-19T08:39:37Z","access_level":"open_access","content_type":"application/pdf","creator":"dernst","date_updated":"2026-10-19T08:39:37Z","file_size":147208}],"has_accepted_license":"1","publication_status":"published","alternative_title":["Lecture Notes in Informatics"],"citation":{"ieee":"C. Richter, M. Chalupa, M. C. Jakobs, and H. Wehrheim, “Off-the-Shelf cooperative software verification by splitting programs dynamically,” in Software Engineering 2026, Bonn, Switzerland, 2026, vol. P-377, pp. 41–42.","ama":"Richter C, Chalupa M, Jakobs MC, Wehrheim H. Off-the-Shelf cooperative software verification by splitting programs dynamically. In: Software Engineering 2026. Vol P-377. Gesellschaft für Informatik; 2026:41-42. doi:10.18420/se2026_45","apa":"Richter, C., Chalupa, M., Jakobs, M. C., & Wehrheim, H. (2026). Off-the-Shelf cooperative software verification by splitting programs dynamically. In Software Engineering 2026 (Vol. P-377, pp. 41–42). Bonn, Switzerland: Gesellschaft für Informatik. https://doi.org/10.18420/se2026_45","chicago":"Richter, Cedric, Marek Chalupa, Marie Christine Jakobs, and Heike Wehrheim. “Off-the-Shelf Cooperative Software Verification by Splitting Programs Dynamically.” In Software Engineering 2026, P-377:41–42. Gesellschaft für Informatik, 2026. https://doi.org/10.18420/se2026_45.","mla":"Richter, Cedric, et al. “Off-the-Shelf Cooperative Software Verification by Splitting Programs Dynamically.” Software Engineering 2026, vol. P-377, Gesellschaft für Informatik, 2026, pp. 41–42, doi:10.18420/se2026_45.","short":"C. Richter, M. Chalupa, M.C. Jakobs, H. Wehrheim, in:, Software Engineering 2026, Gesellschaft für Informatik, 2026, pp. 41–42.","ista":"Richter C, Chalupa M, Jakobs MC, Wehrheim H. 2026. Off-the-Shelf cooperative software verification by splitting programs dynamically. Software Engineering 2026. SE: Software Engineering, Lecture Notes in Informatics, vol. P-377, 41–42."},"day":"01","das_tickbox":"1","publication":"Software Engineering 2026","quality_controlled":"1","_id":"22622"},{"dataavailabilitystatement":"Supporting Information is available free of charge at https://pubs.acs.org/10.1021/acschembio.6c00587.\r\n\r\nDetailed description of experimental methods; spectra supporting the residue assignment for IiMDH; relaxation analysis of IiMDH proline-Cδ sites; NMR spectra of isolated [13Cδ,15N,2Hβγ4]-Pro (PDF)","year":"2026","abstract":[{"text":"The prevalence of proline residues in intrinsically disordered proteins, functional hinges of enzymes, and protein interaction sites highlights the importance of studying their local dynamics and interactions at atomic resolution. While nuclear magnetic resonance (NMR) spectroscopy is, in principle, ideally suited for such investigations, the absence of an amide proton precludes the use of conventional 1H–15N amide-detected experiments. 1H–13C-based approaches, though possible, remain challenging in large proteins. In this work, we present a selective labeling strategy that introduces an isolated 1H2δ–13Cδ–15N spin system in proline residues in otherwise deuterated proteins. Our method leverages the enzymatic conversion of ornithine, synthesized from cost-effective isotopic precursors. We demonstrate the utility of this approach by applying it to a 134 kDa enzyme using magic-angle spinning NMR, highlighting its potential to efficiently probe functionally relevant sites in proteins.","lang":"eng"}],"title":"Chemoenzymatic proline isotope labeling for solution and magic-angle spinning protein nuclear magnetic resonance","status":"public","corr_author":"1","OA_place":"publisher","acknowledgement":"We thank Undina Guillerm, Rajkumar Singh and Anna Kapitonova for help with protein production. We are grateful to Dominique Madern for discussions and for providing the plasmid of IiMDH. We acknowledge the Scientific Service Units (SSU) of the Institute of Science and Technology Austria (ISTA) through resources provided by the NMR Facility and the Lab Support Facility, as well as the NMR centre and MS centre of the University of Vienna. This work was supported by the Austrian Science Fund (FWF; project number I5812-B) through a French-Austrian binational research project, as well as by the L’Oréal-UNESCO For Women in Science Fellowship, awarded in cooperation with the Austrian Academy of Sciences (ÖAW) and the Austrian Commission for UNESCO.","_id":"23173","citation":{"mla":"Rohden, Darja, et al. “Chemoenzymatic Proline Isotope Labeling for Solution and Magic-Angle Spinning Protein Nuclear Magnetic Resonance.” ACS Chemical Biology, American Chemical Society, 2026, doi:10.1021/acschembio.6c00587.","chicago":"Rohden, Darja, Federico Napoli, Roman J. Lichtenecker, and Paul Schanda. “Chemoenzymatic Proline Isotope Labeling for Solution and Magic-Angle Spinning Protein Nuclear Magnetic Resonance.” ACS Chemical Biology. American Chemical Society, 2026. https://doi.org/10.1021/acschembio.6c00587.","ista":"Rohden D, Napoli F, Lichtenecker RJ, Schanda P. 2026. Chemoenzymatic proline isotope labeling for solution and magic-angle spinning protein nuclear magnetic resonance. ACS Chemical Biology.","short":"D. Rohden, F. Napoli, R.J. Lichtenecker, P. Schanda, ACS Chemical Biology (2026).","ama":"Rohden D, Napoli F, Lichtenecker RJ, Schanda P. Chemoenzymatic proline isotope labeling for solution and magic-angle spinning protein nuclear magnetic resonance. ACS Chemical Biology. 2026. doi:10.1021/acschembio.6c00587","ieee":"D. Rohden, F. Napoli, R. J. Lichtenecker, and P. Schanda, “Chemoenzymatic proline isotope labeling for solution and magic-angle spinning protein nuclear magnetic resonance,” ACS Chemical Biology. American Chemical Society, 2026.","apa":"Rohden, D., Napoli, F., Lichtenecker, R. J., & Schanda, P. (2026). Chemoenzymatic proline isotope labeling for solution and magic-angle spinning protein nuclear magnetic resonance. ACS Chemical Biology. American Chemical Society. https://doi.org/10.1021/acschembio.6c00587"},"day":"13","das_tickbox":"1","quality_controlled":"1","publication":"ACS Chemical Biology","has_accepted_license":"1","publication_status":"epub_ahead","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1021/acschembio.6c00587","date_published":"2026-10-13T00:00:00Z","external_id":{"pmid":["42863127"]},"publication_identifier":{"eissn":["1554-8937"],"issn":["1554-8929"]},"main_file_link":[{"url":"https://doi.org/10.1021/acschembio.6c00587","open_access":"1"}],"type":"journal_article","month":"10","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-19T11:12:28Z","date_updated":"2026-10-19T11:20:33Z","ddc":["540"],"oa_version":"Published Version","article_type":"original","publisher":"American Chemical Society","pmid":1,"scopus_import":"1","oa":1,"department":[{"_id":"PaSc"},{"_id":"GradSch"}],"OA_type":"hybrid","author":[{"first_name":"Darja","id":"81dc668a-19fa-11f0-bf31-d56534059ef3","full_name":"Rohden, Darja","last_name":"Rohden"},{"full_name":"Napoli, Federico","last_name":"Napoli","orcid":"0000-0002-9043-136X","first_name":"Federico","id":"d42e08e7-f4fc-11eb-af0a-d71e26138f1b"},{"first_name":"Roman J.","full_name":"Lichtenecker, Roman J.","last_name":"Lichtenecker"},{"orcid":"0000-0002-9350-7606","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","first_name":"Paul","last_name":"Schanda","full_name":"Schanda, Paul"}],"article_processing_charge":"Yes (via OA deal)","acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"project":[{"grant_number":"I05812","name":"AlloSpace. The emergence and mechanisms of allostery","_id":"eb9c82eb-77a9-11ec-83b8-aadd536561cf"}],"fulldoi":"https://doi.org/10.1021/acschembio.6c00587","language":[{"iso":"eng"}]},{"_id":"23046","day":"01","citation":{"apa":"Torres Rodriguez, S. (2026). Implications for the formation of Oort cloud-like structures and interstellar comets in dense environments. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202554978","ieee":"S. Torres Rodriguez, “Implications for the formation of Oort cloud-like structures and interstellar comets in dense environments,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026.","ama":"Torres Rodriguez S. Implications for the formation of Oort cloud-like structures and interstellar comets in dense environments. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202554978","ista":"Torres Rodriguez S. 2026. Implications for the formation of Oort cloud-like structures and interstellar comets in dense environments. Astronomy & Astrophysics. 708, A301.","short":"S. Torres Rodriguez, Astronomy & Astrophysics 708 (2026).","mla":"Torres Rodriguez, Santiago. “Implications for the Formation of Oort Cloud-like Structures and Interstellar Comets in Dense Environments.” Astronomy & Astrophysics, vol. 708, A301, EDP Sciences, 2026, doi:10.1051/0004-6361/202554978.","chicago":"Torres Rodriguez, Santiago. “Implications for the Formation of Oort Cloud-like Structures and Interstellar Comets in Dense Environments.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202554978."},"quality_controlled":"1","publication":"Astronomy & Astrophysics","das_tickbox":"1","publication_status":"published","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_updated":"2026-10-07T12:22:19Z","file_size":9478404,"creator":"dernst","content_type":"application/pdf","date_created":"2026-10-07T12:22:19Z","access_level":"open_access","checksum":"3ea1c5f0fabaa005a4aac7e46f4b6d9c","relation":"main_file","file_name":"2026_AstronomyAstrophysics_Torres.pdf","file_id":"23076","success":1}],"dataavailabilitystatement":"Movies associated with Figs. 3 and 9 are available at https://www.aanda.org","abstract":[{"lang":"eng","text":"Most stars form in dense stellar environments, where frequent close encounters can strongly perturb and reshape the early architecture of planetary systems. The Solar System, with its rich population of distant comets, provides a natural laboratory to study these processes. We performed detailed numerical simulations using the LonelyPlanets framework that combines NBODY6++GPU and REBOUND to explore the evolution of debris disks around Solar System analogues embedded in stellar clusters. Two initial configurations are considered, the Extended model and the Compact model, each containing four giant planets and either an extended or compact debris disk. We find that compact disks primarily form Kuiper belt and scattered disk-like populations through planet–disk interactions, while extended disks are more strongly shaped by stellar encounters, producing Oort cloud-like structures and interstellar comets with ejection velocities of 1–3 km s−1. Stellar perturbations are most effective for encounter inclinations between 0° and 30°, giving rise to distinct dynamical populations, like Sednoids, and inner Oort cloud analogues, and a characteristic tail in semimajor axis-eccentricity space. In coplanar encounters, the disk remains largely flattened, whereas polar flybys redistribute angular momentum vertically, producing nearly isotropic outer populations that resemble an emerging Oort cloud. Our results suggest that cometary reservoirs and interstellar objects are natural byproducts of planet–disk interactions and stellar flybys in dense clusters, linking the architecture of outer planetary systems to their birth environments."}],"year":"2026","title":"Implications for the formation of Oort cloud-like structures and interstellar comets in dense environments","status":"public","corr_author":"1","OA_place":"publisher","acknowledgement":"We thank the referee for their suggestions and comments,\r\nwhich helped us improve the quality and clarity of the paper. S.T. thanks\r\nYlva Götberg, Maxwell Cai, Diptajyoti Mukherjee, Simon Portegies Zwart, and\r\nAnthony Brown for their valuable feedback and comments. S.T. acknowledges\r\nthe funding from the European Union’s Horizon 2020 research and innovation\r\nprogram under the Marie Skłodowska-Curie grant agreement No 101034413.","DOAJ_listed":"1","supplementarymaterial":"no","type":"journal_article","ec_funded":1,"month":"04","date_published":"2026-04-01T00:00:00Z","doi":"10.1051/0004-6361/202554978","arxiv":1,"external_id":{"arxiv":["2510.23653"]},"publication_identifier":{"issn":["0004-6361"],"eissn":["1432-0746"]},"researchdata_availability":"no","file_date_updated":"2026-10-07T12:22:19Z","ddc":["520"],"volume":708,"oa_version":"Published Version","article_type":"original","publisher":"EDP Sciences","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-04T22:01:54Z","PlanS_conform":"1","date_updated":"2026-10-20T08:14:04Z","intvolume":" 708","project":[{"call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413"}],"fulldoi":"https://doi.org/10.1051/0004-6361/202554978","language":[{"iso":"eng"}],"oa":1,"scopus_import":"1","author":[{"full_name":"Torres Rodriguez, Santiago","last_name":"Torres Rodriguez","orcid":"0000-0002-3150-8988","first_name":"Santiago","id":"a8df4360-4328-11ee-8f1a-e502d0c83fc2"}],"department":[{"_id":"LiBu"}],"article_processing_charge":"No","OA_type":"diamond","article_number":"A301"},{"_id":"22306","citation":{"apa":"Kaufman, J. G. G., Tagiltsev, G., Stalder, D. S., Taylor, R. J., Sava, I., Guo, H., … Owen, D. J. (2026). Architecture of clathrin-independent AP3:ARF1-coated carriers. Science Advances. AAAS. https://doi.org/10.1126/sciadv.aed1529","ieee":"J. G. G. Kaufman et al., “Architecture of clathrin-independent AP3:ARF1-coated carriers,” Science Advances, vol. 12, no. 20. AAAS, 2026.","ama":"Kaufman JGG, Tagiltsev G, Stalder DS, et al. Architecture of clathrin-independent AP3:ARF1-coated carriers. Science Advances. 2026;12(20). doi:10.1126/sciadv.aed1529","short":"J.G.G. Kaufman, G. Tagiltsev, D.S. Stalder, R.J. Taylor, I. Sava, H. Guo, K.A. Ciazynska, N.R. Zaccai, S.R. Gray, Y. Vallis, S. Höning, B.T. Kelly, D.C. Gershlick, J.A.G. Briggs, D.J. Owen, Science Advances 12 (2026).","ista":"Kaufman JGG, Tagiltsev G, Stalder DS, Taylor RJ, Sava I, Guo H, Ciazynska KA, Zaccai NR, Gray SR, Vallis Y, Höning S, Kelly BT, Gershlick DC, Briggs JAG, Owen DJ. 2026. Architecture of clathrin-independent AP3:ARF1-coated carriers. Science Advances. 12(20), eaed1529.","mla":"Kaufman, Jonathan G. G., et al. “Architecture of Clathrin-Independent AP3:ARF1-Coated Carriers.” Science Advances, vol. 12, no. 20, eaed1529, AAAS, 2026, doi:10.1126/sciadv.aed1529.","chicago":"Kaufman, Jonathan G.G., Grigory Tagiltsev, Danièle S. Stalder, Rebecca J. Taylor, Ioana Sava, Hui Guo, Katarzyna A. Ciazynska, et al. “Architecture of Clathrin-Independent AP3:ARF1-Coated Carriers.” Science Advances. AAAS, 2026. https://doi.org/10.1126/sciadv.aed1529."},"day":"15","publication":"Science Advances","quality_controlled":"1","das_tickbox":"1","has_accepted_license":"1","publication_status":"published","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_size":8269526,"date_updated":"2026-07-14T06:45:37Z","creator":"dernst","content_type":"application/pdf","access_level":"open_access","date_created":"2026-07-14T06:45:37Z","relation":"main_file","checksum":"461b5f73941fe6b5df2a129c7563601f","file_name":"2026_ScienceAdv_Kaufman.pdf","success":1,"file_id":"22331"}],"dataavailabilitystatement":"Structures determined by electron microscopy are deposited in the Electron\r\nMicroscopy Data Bank under accession codes EMD-54255,\r\nEMD-54256,\r\nEMD-54257,\r\nand\r\nEMD-54258.\r\nCorresponding molecular models are deposited in the Protein Data Bank under\r\naccession codes 9RTW, 9RTX, 9RTY, and 9RTZ. All additional data and code required to\r\nevaluate and reproduce the results in the paper are present in the paper and/or the\r\nsupplementary materials. Any code used is explicitly stated and available in the original\r\npublications. Plasmids and cell lines can be requested by writing to D.C.G. (dg553@ cam. ac. uk)\r\nor D.J.O. (djo30@ cam. ac. uk). All reasonable requests for materials will be honored.","year":"2026","abstract":[{"text":"The AP3 complex mediates cargo sorting and carrier assembly for the trafficking of transmembrane proteins from endosomes to lysosomes. AP3 is generally believed to localize to clathrin-free, ARF1-positive, elongated carriers in cells, but the architecture of AP3-based coats was unknown. Using in vitro reconstitution and cryo–electron tomography, we demonstrate that AP3:ARF1 spontaneously remodels membranes containing cargo and the phosphoinositide PI(3,5)P\r\n 2\r\n into tubular structures coated in spiraling rows of AP3 arches and ARF1 dimers. Targeted point mutations disrupting critical AP3:ARF1 and AP3:AP3 lattice interfaces disrupt AP3 recruitment, carrier formation, and lysosomal cargo trafficking in cells. We propose that AP3 generates tubular carriers on endosomes by organizing ARF1 dimers into elongated membrane-deforming arrays while simultaneously selecting cargo. By demonstrating that AP3:ARF1 can generate carriers without using a clathrin lattice, we explain the clathrin independence of AP3-mediated trafficking.","lang":"eng"}],"title":"Architecture of clathrin-independent AP3:ARF1-coated carriers","status":"public","acknowledgement":"We thank P. Luzio, N. Bright, and M. S. Robinson for helpful discussions;\r\nJ. Stacey and Y. Fujiharu for technical discussions and assistance; F. Beck for assistance with\r\ncomputing infrastructure; and M. Riggi for discussion of data presentation and figure design.\r\nCryo-E\r\nM data was collected at the Department of Cell and Virus Structure, Max Planck Institute\r\nof Biochemistry. Funding: This work was funded by: the Wellcome Trust, Wellcome Discovery\r\nAward 227915/Z/23/Z (to D.J.O., J.A.G.B., and D.G.S.) and Wellcome PRF 207455/Z/17/Z (to\r\nD.J.O.); the Max Planck Society (to J.A.G.B.); the Medical Research Council (UKRI) MC_\r\nUP_1201/16 (to J.A.G.B.) and MRC DT P MR/N013433/1 (to J.G.G.K.); EMBO Long-term\r\nPostdoctoral Fellowship ALT F-383-\r\n2022\r\n(to G.T.); and the Wellcome Trust/Royal Society, Sir\r\nHenry Dale Fellowship 210481 (to D.C.G) and the Biotechnology and Biological Sciences\r\nResearch Council (UKRI) responsive mode grants BB/W005905/1 and UKRI715 (to D.C.G.).","OA_place":"publisher","DOAJ_listed":"1","supplementarymaterial":"yes","type":"journal_article","month":"05","doi":"10.1126/sciadv.aed1529","date_published":"2026-05-15T00:00:00Z","publication_identifier":{"eissn":["2375-2548"]},"researchdata_availability":"yes","ddc":["570"],"file_date_updated":"2026-07-14T06:45:37Z","volume":12,"oa_version":"Published Version","article_type":"original","publisher":"AAAS","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-07-13T10:52:15Z","PlanS_conform":"1","date_updated":"2026-10-20T08:11:46Z","intvolume":" 12","issue":"20","fulldoi":"https://doi.org/10.1126/sciadv.aed1529","language":[{"iso":"eng"}],"oa":1,"scopus_import":"1","OA_type":"gold","author":[{"first_name":"Jonathan G.G.","last_name":"Kaufman","full_name":"Kaufman, Jonathan G.G."},{"first_name":"Grigory","last_name":"Tagiltsev","full_name":"Tagiltsev, Grigory"},{"last_name":"Stalder","full_name":"Stalder, Danièle S.","first_name":"Danièle S."},{"first_name":"Rebecca J.","last_name":"Taylor","full_name":"Taylor, Rebecca J."},{"last_name":"Sava","full_name":"Sava, Ioana","first_name":"Ioana"},{"full_name":"Guo, Hui","last_name":"Guo","first_name":"Hui"},{"first_name":"Katarzyna A.","full_name":"Ciazynska, Katarzyna A.","last_name":"Ciazynska"},{"first_name":"Nathan R.","full_name":"Zaccai, Nathan R.","last_name":"Zaccai"},{"full_name":"Gray, Sally R.","last_name":"Gray","first_name":"Sally R."},{"full_name":"Vallis, Yvonne","last_name":"Vallis","orcid":"0000-0002-5408-5906","first_name":"Yvonne","id":"05A2795C-31B5-11EA-83A7-7DA23DDC885E"},{"first_name":"Stefan","full_name":"Höning, Stefan","last_name":"Höning"},{"first_name":"Bernard T.","full_name":"Kelly, Bernard T.","last_name":"Kelly"},{"last_name":"Gershlick","full_name":"Gershlick, David C.","first_name":"David C."},{"first_name":"John A.G.","full_name":"Briggs, John A.G.","last_name":"Briggs"},{"first_name":"David J.","full_name":"Owen, David J.","last_name":"Owen"}],"article_processing_charge":"Yes","department":[{"_id":"MaDe"}],"article_number":"eaed1529"}]