[{"oa":1,"quality_controlled":"1","volume":11316,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","alternative_title":["LNCS"],"day":"21","page":"21-36","citation":{"short":"G. Avni, T.A. Henzinger, R. Ibsen-Jensen, in:, Springer, 2018, pp. 21–36.","ista":"Avni G, Henzinger TA, Ibsen-Jensen R. 2018. Infinite-duration poorman-bidding games. 14th International Conference on Web and Internet Economics, WINE, LNCS, vol. 11316, 21–36.","chicago":"Avni, Guy, Thomas A Henzinger, and Rasmus Ibsen-Jensen. “Infinite-Duration Poorman-Bidding Games,” 11316:21–36. Springer, 2018. <a href=\"https://doi.org/10.1007/978-3-030-04612-5_2\">https://doi.org/10.1007/978-3-030-04612-5_2</a>.","apa":"Avni, G., Henzinger, T. A., &#38; Ibsen-Jensen, R. (2018). Infinite-duration poorman-bidding games (Vol. 11316, pp. 21–36). Presented at the 14th International Conference on Web and Internet Economics, WINE, Oxford, UK: Springer. <a href=\"https://doi.org/10.1007/978-3-030-04612-5_2\">https://doi.org/10.1007/978-3-030-04612-5_2</a>","ieee":"G. Avni, T. A. Henzinger, and R. Ibsen-Jensen, “Infinite-duration poorman-bidding games,” presented at the 14th International Conference on Web and Internet Economics, WINE, Oxford, UK, 2018, vol. 11316, pp. 21–36.","ama":"Avni G, Henzinger TA, Ibsen-Jensen R. Infinite-duration poorman-bidding games. In: Vol 11316. Springer; 2018:21-36. doi:<a href=\"https://doi.org/10.1007/978-3-030-04612-5_2\">10.1007/978-3-030-04612-5_2</a>","mla":"Avni, Guy, et al. <i>Infinite-Duration Poorman-Bidding Games</i>. Vol. 11316, Springer, 2018, pp. 21–36, doi:<a href=\"https://doi.org/10.1007/978-3-030-04612-5_2\">10.1007/978-3-030-04612-5_2</a>."},"status":"public","scopus_import":"1","publisher":"Springer","conference":{"name":"14th International Conference on Web and Internet Economics, WINE","start_date":"2018-12-15","end_date":"2018-12-17","location":"Oxford, UK"},"date_updated":"2026-04-16T09:54:39Z","year":"2018","author":[{"full_name":"Avni, Guy","first_name":"Guy","last_name":"Avni","orcid":"0000-0001-5588-8287","id":"463C8BC2-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Henzinger, Thomas A","last_name":"Henzinger","first_name":"Thomas A","orcid":"0000−0002−2985−7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"id":"3B699956-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4783-0389","last_name":"Ibsen-Jensen","first_name":"Rasmus","full_name":"Ibsen-Jensen, Rasmus"}],"publication_identifier":{"isbn":["9783030046118"],"issn":["0302-9743"]},"project":[{"call_identifier":"FWF","_id":"25F42A32-B435-11E9-9278-68D0E5697425","name":"Formal methods for the design and analysis of complex systems","grant_number":"Z211"},{"name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"call_identifier":"FWF","name":"Formal Methods meets Algorithmic Game Theory","grant_number":"M02369","_id":"264B3912-B435-11E9-9278-68D0E5697425"}],"external_id":{"arxiv":["1804.04372"],"isi":["000865933000002"]},"abstract":[{"lang":"eng","text":"In two-player games on graphs, the players move a token through a graph to produce an infinite path, which determines the winner or payoff of the game. Such games are central in formal verification since they model the interaction between a non-terminating system and its environment. We study bidding games in which the players bid for the right to move the token. Two bidding rules have been defined. In Richman bidding, in each round, the players simultaneously submit bids, and the higher bidder moves the token and pays the other player. Poorman bidding is similar except that the winner of the bidding pays the “bank” rather than the other player. While poorman reachability games have been studied before, we present, for the first time, results on infinite-duration poorman games. A central quantity in these games is the ratio between the two players’ initial budgets. The questions we study concern a necessary and sufficient ratio with which a player can achieve a goal. For reachability objectives, such threshold ratios are known to exist for both bidding rules. We show that the properties of poorman reachability games extend to complex qualitative objectives such as parity, similarly to the Richman case. Our most interesting results concern quantitative poorman games, namely poorman mean-payoff games, where we construct optimal strategies depending on the initial ratio, by showing a connection with random-turn based games. The connection in itself is interesting, because it does not hold for reachability poorman games. We also solve the complexity problems that arise in poorman bidding games."}],"month":"11","type":"conference","arxiv":1,"main_file_link":[{"url":"https://arxiv.org/abs/1804.04372","open_access":"1"}],"article_processing_charge":"No","doi":"10.1007/978-3-030-04612-5_2","oa_version":"Preprint","date_created":"2018-12-30T22:59:14Z","title":"Infinite-duration poorman-bidding games","department":[{"_id":"ToHe"}],"intvolume":"     11316","language":[{"iso":"eng"}],"date_published":"2018-11-21T00:00:00Z","isi":1,"_id":"5788"},{"date_published":"2018-12-01T00:00:00Z","isi":1,"_id":"5679","intvolume":"     11275","language":[{"iso":"eng"}],"date_created":"2018-12-16T22:59:20Z","doi":"10.1007/978-3-030-02768-1_11","oa_version":"Preprint","article_processing_charge":"No","main_file_link":[{"url":"http://arxiv.org/abs/1806.06683","open_access":"1"}],"title":"New approaches for almost-sure termination of probabilistic programs","department":[{"_id":"KrCh"}],"publication_identifier":{"issn":["0302-9743"],"isbn":["9783030027674"]},"external_id":{"arxiv":["1806.06683"],"isi":["000916310900011"]},"project":[{"grant_number":"S 11407_N23","name":"Rigorous Systems Engineering","_id":"25832EC2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"_id":"25892FC0-B435-11E9-9278-68D0E5697425","grant_number":"ICT15-003","name":"Efficient Algorithms for Computer Aided Verification"}],"type":"conference","month":"12","arxiv":1,"abstract":[{"text":"We study the almost-sure termination problem for probabilistic programs. First, we show that supermartingales with lower bounds on conditional absolute difference provide a sound approach for the almost-sure termination problem. Moreover, using this approach we can obtain explicit optimal bounds on tail probabilities of non-termination within a given number of steps. Second, we present a new approach based on Central Limit Theorem for the almost-sure termination problem, and show that this approach can establish almost-sure termination of programs which none of the existing approaches can handle. Finally, we discuss algorithmic approaches for the two above methods that lead to automated analysis techniques for almost-sure termination of probabilistic programs.","lang":"eng"}],"date_updated":"2026-04-16T09:54:21Z","editor":[{"first_name":"Sukyoung","last_name":"Ryu","full_name":"Ryu, Sukyoung"}],"author":[{"last_name":"Huang","first_name":"Mingzhang","full_name":"Huang, Mingzhang"},{"full_name":"Fu, Hongfei","last_name":"Fu","first_name":"Hongfei"},{"full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X"}],"year":"2018","citation":{"short":"M. Huang, H. Fu, K. Chatterjee, in:, S. Ryu (Ed.), Springer, 2018, pp. 181–201.","ista":"Huang M, Fu H, Chatterjee K. 2018. New approaches for almost-sure termination of probabilistic programs. 16th Asian Symposium on Programming Languages and Systems, APLAS, LNCS, vol. 11275, 181–201.","chicago":"Huang, Mingzhang, Hongfei Fu, and Krishnendu Chatterjee. “New Approaches for Almost-Sure Termination of Probabilistic Programs.” edited by Sukyoung Ryu, 11275:181–201. Springer, 2018. <a href=\"https://doi.org/10.1007/978-3-030-02768-1_11\">https://doi.org/10.1007/978-3-030-02768-1_11</a>.","ama":"Huang M, Fu H, Chatterjee K. New approaches for almost-sure termination of probabilistic programs. In: Ryu S, ed. Vol 11275. Springer; 2018:181-201. doi:<a href=\"https://doi.org/10.1007/978-3-030-02768-1_11\">10.1007/978-3-030-02768-1_11</a>","apa":"Huang, M., Fu, H., &#38; Chatterjee, K. (2018). New approaches for almost-sure termination of probabilistic programs. In S. Ryu (Ed.) (Vol. 11275, pp. 181–201). Presented at the 16th Asian Symposium on Programming Languages and Systems, APLAS, Wellington, New Zealand: Springer. <a href=\"https://doi.org/10.1007/978-3-030-02768-1_11\">https://doi.org/10.1007/978-3-030-02768-1_11</a>","ieee":"M. Huang, H. Fu, and K. Chatterjee, “New approaches for almost-sure termination of probabilistic programs,” presented at the 16th Asian Symposium on Programming Languages and Systems, APLAS, Wellington, New Zealand, 2018, vol. 11275, pp. 181–201.","mla":"Huang, Mingzhang, et al. <i>New Approaches for Almost-Sure Termination of Probabilistic Programs</i>. Edited by Sukyoung Ryu, vol. 11275, Springer, 2018, pp. 181–201, doi:<a href=\"https://doi.org/10.1007/978-3-030-02768-1_11\">10.1007/978-3-030-02768-1_11</a>."},"page":"181-201","status":"public","conference":{"location":"Wellington, New Zealand","name":"16th Asian Symposium on Programming Languages and Systems, APLAS","start_date":"2018-12-02","end_date":"2018-12-06"},"publisher":"Springer","scopus_import":"1","volume":11275,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","day":"01","alternative_title":["LNCS"],"oa":1,"quality_controlled":"1"},{"language":[{"iso":"eng"}],"publication_status":"published","intvolume":"       215","_id":"5672","isi":1,"date_published":"2018-11-20T00:00:00Z","external_id":{"isi":["000451920600002"]},"abstract":[{"text":"The release of IgM is the first line of an antibody response and precedes the generation of high affinity IgG in germinal centers. Once secreted by freshly activated plasmablasts, IgM is released into the efferent lymph of reactive lymph nodes as early as 3 d after immunization. As pentameric IgM has an enormous size of 1,000 kD, its diffusibility is low, and one might wonder how it can pass through the densely lymphocyte-packed environment of a lymph node parenchyma in order to reach its exit. In this issue of JEM, Thierry et al. show that, in order to reach the blood stream, IgM molecules take a specific micro-anatomical route via lymph node conduits.","lang":"eng"}],"month":"11","file_date_updated":"2020-07-14T12:47:09Z","type":"journal_article","publication_identifier":{"issn":["0022-1007"]},"department":[{"_id":"MiSi"}],"article_processing_charge":"No","doi":"10.1084/jem.20181934","oa_version":"Published Version","date_created":"2018-12-16T22:59:18Z","title":"IgM's exit route","scopus_import":"1","has_accepted_license":"1","file":[{"file_id":"5931","relation":"main_file","file_name":"2018_JournalExperMed_Reversat.pdf","creator":"dernst","content_type":"application/pdf","file_size":1216437,"checksum":"687beea1d64c213f4cb9e3c29ec11a14","date_created":"2019-02-06T08:49:52Z","date_updated":"2020-07-14T12:47:09Z","access_level":"open_access"}],"publisher":"Rockefeller University Press","page":"2959-2961","ddc":["570"],"citation":{"ama":"Reversat A, Sixt MK. IgM’s exit route. <i>Journal of Experimental Medicine</i>. 2018;215(12):2959-2961. doi:<a href=\"https://doi.org/10.1084/jem.20181934\">10.1084/jem.20181934</a>","ieee":"A. Reversat and M. K. Sixt, “IgM’s exit route,” <i>Journal of Experimental Medicine</i>, vol. 215, no. 12. Rockefeller University Press, pp. 2959–2961, 2018.","apa":"Reversat, A., &#38; Sixt, M. K. (2018). IgM’s exit route. <i>Journal of Experimental Medicine</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1084/jem.20181934\">https://doi.org/10.1084/jem.20181934</a>","mla":"Reversat, Anne, and Michael K. Sixt. “IgM’s Exit Route.” <i>Journal of Experimental Medicine</i>, vol. 215, no. 12, Rockefeller University Press, 2018, pp. 2959–61, doi:<a href=\"https://doi.org/10.1084/jem.20181934\">10.1084/jem.20181934</a>.","short":"A. Reversat, M.K. Sixt, Journal of Experimental Medicine 215 (2018) 2959–2961.","chicago":"Reversat, Anne, and Michael K Sixt. “IgM’s Exit Route.” <i>Journal of Experimental Medicine</i>. Rockefeller University Press, 2018. <a href=\"https://doi.org/10.1084/jem.20181934\">https://doi.org/10.1084/jem.20181934</a>.","ista":"Reversat A, Sixt MK. 2018. IgM’s exit route. Journal of Experimental Medicine. 215(12), 2959–2961."},"status":"public","publication":"Journal of Experimental Medicine","year":"2018","author":[{"first_name":"Anne","last_name":"Reversat","full_name":"Reversat, Anne","orcid":"0000-0003-0666-8928","id":"35B76592-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","last_name":"Sixt","first_name":"Michael K"}],"date_updated":"2026-04-16T09:54:07Z","oa":1,"quality_controlled":"1","tmp":{"image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","day":"20","issue":"12","volume":215},{"publist_id":"6992","intvolume":"        40","publication_status":"published","language":[{"iso":"eng"}],"date_published":"2018-07-01T00:00:00Z","_id":"703","isi":1,"corr_author":"1","publication_identifier":{"issn":["0162-8828"]},"external_id":{"isi":["000434294800010"],"arxiv":["1508.07902"]},"type":"journal_article","arxiv":1,"month":"07","abstract":[{"lang":"eng","text":"We consider the NP-hard problem of MAP-inference for undirected discrete graphical models. We propose a polynomial time and practically efficient algorithm for finding a part of its optimal solution. Specifically, our algorithm marks some labels of the considered graphical model either as (i) optimal, meaning that they belong to all optimal solutions of the inference problem; (ii) non-optimal if they provably do not belong to any solution. With access to an exact solver of a linear programming relaxation to the MAP-inference problem, our algorithm marks the maximal possible (in a specified sense) number of labels. We also present a version of the algorithm, which has access to a suboptimal dual solver only and still can ensure the (non-)optimality for the marked labels, although the overall number of the marked labels may decrease. We propose an efficient implementation, which runs in time comparable to a single run of a suboptimal dual solver. Our method is well-scalable and shows state-of-the-art results on computational benchmarks from machine learning and computer vision."}],"doi":"10.1109/TPAMI.2017.2730884","date_created":"2018-12-11T11:48:01Z","oa_version":"Preprint","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1508.07902"}],"title":"Maximum persistency via iterative relaxed inference with graphical models","department":[{"_id":"VlKo"}],"citation":{"chicago":"Shekhovtsov, Alexander, Paul Swoboda, and Bogdan Savchynskyy. “Maximum Persistency via Iterative Relaxed Inference with Graphical Models.” <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. IEEE, 2018. <a href=\"https://doi.org/10.1109/TPAMI.2017.2730884\">https://doi.org/10.1109/TPAMI.2017.2730884</a>.","ista":"Shekhovtsov A, Swoboda P, Savchynskyy B. 2018. Maximum persistency via iterative relaxed inference with graphical models. IEEE Transactions on Pattern Analysis and Machine Intelligence. 40(7), 1668–1682.","short":"A. Shekhovtsov, P. Swoboda, B. Savchynskyy, IEEE Transactions on Pattern Analysis and Machine Intelligence 40 (2018) 1668–1682.","apa":"Shekhovtsov, A., Swoboda, P., &#38; Savchynskyy, B. (2018). Maximum persistency via iterative relaxed inference with graphical models. <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. IEEE. <a href=\"https://doi.org/10.1109/TPAMI.2017.2730884\">https://doi.org/10.1109/TPAMI.2017.2730884</a>","ama":"Shekhovtsov A, Swoboda P, Savchynskyy B. Maximum persistency via iterative relaxed inference with graphical models. <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. 2018;40(7):1668-1682. doi:<a href=\"https://doi.org/10.1109/TPAMI.2017.2730884\">10.1109/TPAMI.2017.2730884</a>","mla":"Shekhovtsov, Alexander, et al. “Maximum Persistency via Iterative Relaxed Inference with Graphical Models.” <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>, vol. 40, no. 7, IEEE, 2018, pp. 1668–82, doi:<a href=\"https://doi.org/10.1109/TPAMI.2017.2730884\">10.1109/TPAMI.2017.2730884</a>.","ieee":"A. Shekhovtsov, P. Swoboda, and B. Savchynskyy, “Maximum persistency via iterative relaxed inference with graphical models,” <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>, vol. 40, no. 7. IEEE, pp. 1668–1682, 2018."},"page":"1668-1682","publication":"IEEE Transactions on Pattern Analysis and Machine Intelligence","status":"public","publisher":"IEEE","scopus_import":"1","date_updated":"2026-04-16T09:54:52Z","author":[{"full_name":"Shekhovtsov, Alexander","last_name":"Shekhovtsov","first_name":"Alexander"},{"last_name":"Swoboda","first_name":"Paul","full_name":"Swoboda, Paul","id":"446560C6-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Savchynskyy","first_name":"Bogdan","full_name":"Savchynskyy, Bogdan"}],"year":"2018","oa":1,"quality_controlled":"1","issue":"7","volume":40,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","day":"01"},{"publication_identifier":{"isbn":["9783662583869"],"eisbn":["9783662583876"],"eissn":["1611-3349"],"issn":["0302-9743"]},"external_id":{"isi":["000540656400026"]},"project":[{"_id":"258AA5B2-B435-11E9-9278-68D0E5697425","name":"Teaching Old Crypto New Tricks","grant_number":"682815","call_identifier":"H2020"}],"type":"conference","month":"12","abstract":[{"lang":"eng","text":"Bitcoin has become the most successful cryptocurrency ever deployed, and its most distinctive feature is that it is decentralized. Its underlying protocol (Nakamoto consensus) achieves this by using proof of work, which has the drawback that it causes the consumption of vast amounts of energy to maintain the ledger. Moreover, Bitcoin mining dynamics have become less distributed over time.\r\n\r\nTowards addressing these issues, we propose SpaceMint, a cryptocurrency based on proofs of space instead of proofs of work. Miners in SpaceMint dedicate disk space rather than computation. We argue that SpaceMint’s design solves or alleviates several of Bitcoin’s issues: most notably, its large energy consumption. SpaceMint also rewards smaller miners fairly according to their contribution to the network, thus incentivizing more distributed participation.\r\n\r\nThis paper adapts proof of space to enable its use in cryptocurrency, studies the attacks that can arise against a Bitcoin-like blockchain that uses proof of space, and proposes a new blockchain format and transaction types to address these attacks. Our prototype shows that initializing 1 TB for mining takes about a day (a one-off setup cost), and miners spend on average just a fraction of a second per block mined. Finally, we provide a game-theoretic analysis modeling SpaceMint as an extensive game (the canonical game-theoretic notion for games that take place over time) and show that this stylized game satisfies a strong equilibrium notion, thereby arguing for SpaceMint ’s stability and consensus."}],"date_created":"2019-10-14T06:35:38Z","doi":"10.1007/978-3-662-58387-6_26","oa_version":"Submitted Version","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2015/528"}],"title":"SpaceMint: A cryptocurrency based on proofs of space","department":[{"_id":"KrPi"}],"intvolume":"     10957","publication_status":"published","language":[{"iso":"eng"}],"date_published":"2018-12-07T00:00:00Z","isi":1,"_id":"6941","oa":1,"quality_controlled":"1","volume":10957,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","day":"07","alternative_title":["LNCS"],"page":"480-499","citation":{"short":"S. Park, A. Kwon, G. Fuchsbauer, P. Gazi, J.F. Alwen, K.Z. Pietrzak, in:, 22nd International Conference on Financial Cryptography and Data Security, Springer Nature, 2018, pp. 480–499.","chicago":"Park, Sunoo, Albert Kwon, Georg Fuchsbauer, Peter Gazi, Joel F Alwen, and Krzysztof Z Pietrzak. “SpaceMint: A Cryptocurrency Based on Proofs of Space.” In <i>22nd International Conference on Financial Cryptography and Data Security</i>, 10957:480–99. Springer Nature, 2018. <a href=\"https://doi.org/10.1007/978-3-662-58387-6_26\">https://doi.org/10.1007/978-3-662-58387-6_26</a>.","ista":"Park S, Kwon A, Fuchsbauer G, Gazi P, Alwen JF, Pietrzak KZ. 2018. SpaceMint: A cryptocurrency based on proofs of space. 22nd International Conference on Financial Cryptography and Data Security. FC: Financial Cryptography and Data Security, LNCS, vol. 10957, 480–499.","apa":"Park, S., Kwon, A., Fuchsbauer, G., Gazi, P., Alwen, J. F., &#38; Pietrzak, K. Z. (2018). SpaceMint: A cryptocurrency based on proofs of space. In <i>22nd International Conference on Financial Cryptography and Data Security</i> (Vol. 10957, pp. 480–499). Nieuwpoort, Curacao: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-662-58387-6_26\">https://doi.org/10.1007/978-3-662-58387-6_26</a>","mla":"Park, Sunoo, et al. “SpaceMint: A Cryptocurrency Based on Proofs of Space.” <i>22nd International Conference on Financial Cryptography and Data Security</i>, vol. 10957, Springer Nature, 2018, pp. 480–99, doi:<a href=\"https://doi.org/10.1007/978-3-662-58387-6_26\">10.1007/978-3-662-58387-6_26</a>.","ieee":"S. Park, A. Kwon, G. Fuchsbauer, P. Gazi, J. F. Alwen, and K. Z. Pietrzak, “SpaceMint: A cryptocurrency based on proofs of space,” in <i>22nd International Conference on Financial Cryptography and Data Security</i>, Nieuwpoort, Curacao, 2018, vol. 10957, pp. 480–499.","ama":"Park S, Kwon A, Fuchsbauer G, Gazi P, Alwen JF, Pietrzak KZ. SpaceMint: A cryptocurrency based on proofs of space. In: <i>22nd International Conference on Financial Cryptography and Data Security</i>. Vol 10957. Springer Nature; 2018:480-499. doi:<a href=\"https://doi.org/10.1007/978-3-662-58387-6_26\">10.1007/978-3-662-58387-6_26</a>"},"publication":"22nd International Conference on Financial Cryptography and Data Security","status":"public","publisher":"Springer Nature","conference":{"end_date":"2018-03-02","start_date":"2018-02-26","name":"FC: Financial Cryptography and Data Security","location":"Nieuwpoort, Curacao"},"scopus_import":"1","ec_funded":1,"date_updated":"2026-04-16T10:30:49Z","author":[{"last_name":"Park","first_name":"Sunoo","full_name":"Park, Sunoo"},{"last_name":"Kwon","first_name":"Albert","full_name":"Kwon, Albert"},{"id":"46B4C3EE-F248-11E8-B48F-1D18A9856A87","first_name":"Georg","last_name":"Fuchsbauer","full_name":"Fuchsbauer, Georg"},{"id":"3E0BFE38-F248-11E8-B48F-1D18A9856A87","full_name":"Gazi, Peter","last_name":"Gazi","first_name":"Peter"},{"id":"2A8DFA8C-F248-11E8-B48F-1D18A9856A87","first_name":"Joel F","last_name":"Alwen","full_name":"Alwen, Joel F"},{"full_name":"Pietrzak, Krzysztof Z","last_name":"Pietrzak","first_name":"Krzysztof Z","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9139-1654"}],"year":"2018"},{"quality_controlled":"1","abstract":[{"lang":"eng","text":"This chapter finds an agreement of equivariant indices of semi-classical homomorphisms between pairwise mirror branes in the GL2 Higgs moduli space on a Riemann surface. On one side of the agreement, components of the Lagrangian brane of U(1,1) Higgs bundles, whose mirror was proposed by Hitchin to be certain even exterior powers of the hyperholomorphic Dirac bundle on the SL2 Higgs moduli space, are present. The agreement arises from a mysterious functional equation. This gives strong computational evidence for Hitchin’s proposal."}],"type":"book_chapter","month":"01","publication_identifier":{"eisbn":["9780191840500"],"isbn":["9780198802013"]},"department":[{"_id":"TaHa"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","day":"01","article_processing_charge":"No","date_created":"2019-06-06T12:42:01Z","doi":"10.1093/oso/9780198802013.003.0009","oa_version":"None","title":"Mirror symmetry with branes by equivariant verlinde formulas","language":[{"iso":"eng"}],"scopus_import":"1","publisher":"Oxford University Press","page":"189-218","citation":{"chicago":"Hausel, Tamás, Anton Mellit, and Du Pei. “Mirror Symmetry with Branes by Equivariant Verlinde Formulas.” In <i>Geometry and Physics: Volume I</i>, 189–218. Oxford University Press, 2018. <a href=\"https://doi.org/10.1093/oso/9780198802013.003.0009\">https://doi.org/10.1093/oso/9780198802013.003.0009</a>.","short":"T. Hausel, A. Mellit, D. Pei, in:, Geometry and Physics: Volume I, Oxford University Press, 2018, pp. 189–218.","ista":"Hausel T, Mellit A, Pei D. 2018.Mirror symmetry with branes by equivariant verlinde formulas. In: Geometry and Physics: Volume I. , 189–218.","ama":"Hausel T, Mellit A, Pei D. Mirror symmetry with branes by equivariant verlinde formulas. In: <i>Geometry and Physics: Volume I</i>. Oxford University Press; 2018:189-218. doi:<a href=\"https://doi.org/10.1093/oso/9780198802013.003.0009\">10.1093/oso/9780198802013.003.0009</a>","ieee":"T. Hausel, A. Mellit, and D. Pei, “Mirror symmetry with branes by equivariant verlinde formulas,” in <i>Geometry and Physics: Volume I</i>, Oxford University Press, 2018, pp. 189–218.","mla":"Hausel, Tamás, et al. “Mirror Symmetry with Branes by Equivariant Verlinde Formulas.” <i>Geometry and Physics: Volume I</i>, Oxford University Press, 2018, pp. 189–218, doi:<a href=\"https://doi.org/10.1093/oso/9780198802013.003.0009\">10.1093/oso/9780198802013.003.0009</a>.","apa":"Hausel, T., Mellit, A., &#38; Pei, D. (2018). Mirror symmetry with branes by equivariant verlinde formulas. In <i>Geometry and Physics: Volume I</i> (pp. 189–218). Oxford University Press. <a href=\"https://doi.org/10.1093/oso/9780198802013.003.0009\">https://doi.org/10.1093/oso/9780198802013.003.0009</a>"},"publication_status":"published","publication":"Geometry and Physics: Volume I","status":"public","year":"2018","author":[{"id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9582-2634","full_name":"Hausel, Tamás","first_name":"Tamás","last_name":"Hausel"},{"full_name":"Mellit, Anton","last_name":"Mellit","first_name":"Anton","id":"388D3134-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Pei, Du","last_name":"Pei","first_name":"Du"}],"_id":"6525","date_published":"2018-01-01T00:00:00Z","date_updated":"2026-04-16T10:30:22Z"},{"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"quality_controlled":"1","oa":1,"volume":46,"issue":"6","day":"06","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication":"Nucleic Acids Research","status":"public","ddc":["576"],"citation":{"ista":"Nikolic N, Bergmiller T, Vandervelde A, Albanese T, Gelens L, Moll I. 2018. Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations. Nucleic Acids Research. 46(6), 2918–2931.","chicago":"Nikolic, Nela, Tobias Bergmiller, Alexandra Vandervelde, Tanino Albanese, Lendert Gelens, and Isabella Moll. “Autoregulation of MazEF Expression Underlies Growth Heterogeneity in Bacterial Populations.” <i>Nucleic Acids Research</i>. Oxford University Press, 2018. <a href=\"https://doi.org/10.1093/nar/gky079\">https://doi.org/10.1093/nar/gky079</a>.","short":"N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, I. Moll, Nucleic Acids Research 46 (2018) 2918–2931.","mla":"Nikolic, Nela, et al. “Autoregulation of MazEF Expression Underlies Growth Heterogeneity in Bacterial Populations.” <i>Nucleic Acids Research</i>, vol. 46, no. 6, Oxford University Press, 2018, pp. 2918–31, doi:<a href=\"https://doi.org/10.1093/nar/gky079\">10.1093/nar/gky079</a>.","apa":"Nikolic, N., Bergmiller, T., Vandervelde, A., Albanese, T., Gelens, L., &#38; Moll, I. (2018). Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations. <i>Nucleic Acids Research</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/nar/gky079\">https://doi.org/10.1093/nar/gky079</a>","ieee":"N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, and I. Moll, “Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations,” <i>Nucleic Acids Research</i>, vol. 46, no. 6. Oxford University Press, pp. 2918–2931, 2018.","ama":"Nikolic N, Bergmiller T, Vandervelde A, Albanese T, Gelens L, Moll I. Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations. <i>Nucleic Acids Research</i>. 2018;46(6):2918-2931. doi:<a href=\"https://doi.org/10.1093/nar/gky079\">10.1093/nar/gky079</a>"},"page":"2918-2931","file":[{"creator":"system","file_name":"IST-2018-971-v1+1_2018_Nikoloc_Autoregulation_of.pdf","relation":"main_file","file_id":"5151","checksum":"3ff4f545c27e11a4cd20ccb30778793e","content_type":"application/pdf","file_size":5027978,"date_updated":"2020-07-14T12:46:27Z","access_level":"open_access","date_created":"2018-12-12T10:15:30Z"}],"publisher":"Oxford University Press","scopus_import":"1","has_accepted_license":"1","date_updated":"2025-04-15T06:28:24Z","author":[{"full_name":"Nikolic, Nela","last_name":"Nikolic","first_name":"Nela","orcid":"0000-0001-9068-6090","id":"42D9CABC-F248-11E8-B48F-1D18A9856A87"},{"id":"2C471CFA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5396-4346","full_name":"Bergmiller, Tobias","last_name":"Bergmiller","first_name":"Tobias"},{"full_name":"Vandervelde, Alexandra","first_name":"Alexandra","last_name":"Vandervelde"},{"full_name":"Albanese, Tanino","first_name":"Tanino","last_name":"Albanese"},{"full_name":"Gelens, Lendert","first_name":"Lendert","last_name":"Gelens"},{"first_name":"Isabella","last_name":"Moll","full_name":"Moll, Isabella"}],"year":"2018","corr_author":"1","pubrep_id":"971","type":"journal_article","month":"04","file_date_updated":"2020-07-14T12:46:27Z","abstract":[{"lang":"eng","text":"The MazF toxin sequence-specifically cleaves single-stranded RNA upon various stressful conditions, and it is activated as a part of the mazEF toxin–antitoxin module in Escherichia coli. Although autoregulation of mazEF expression through the MazE antitoxin-dependent transcriptional repression has been biochemically characterized, less is known about post-transcriptional autoregulation, as well as how both of these autoregulatory features affect growth of single cells during conditions that promote MazF production. Here, we demonstrate post-transcriptional autoregulation of mazF expression dynamics by MazF cleaving its own transcript. Single-cell analyses of bacterial populations during ectopic MazF production indicated that two-level autoregulation of mazEF expression influences cell-to-cell growth rate heterogeneity. The increase in growth rate heterogeneity is governed by the MazE antitoxin, and tuned by the MazF-dependent mazF mRNA cleavage. Also, both autoregulatory features grant rapid exit from the stress caused by mazF overexpression. Time-lapse microscopy revealed that MazF-mediated cleavage of mazF mRNA leads to increased temporal variability in length of individual cells during ectopic mazF overexpression, as explained by a stochastic model indicating that mazEF mRNA cleavage underlies temporal fluctuations in MazF levels during stress."}],"external_id":{"isi":["000429009500021"]},"project":[{"name":"FWF Open Access Fund","_id":"3AC91DDA-15DF-11EA-824D-93A3E7B544D1","call_identifier":"FWF"}],"title":"Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations","doi":"10.1093/nar/gky079","oa_version":"Published Version","date_created":"2018-12-11T11:46:29Z","article_processing_charge":"Yes (in subscription journal)","department":[{"_id":"CaGu"}],"intvolume":"        46","publication_status":"published","language":[{"iso":"eng"}],"date_published":"2018-04-06T00:00:00Z","_id":"438","related_material":{"record":[{"relation":"popular_science","id":"5569","status":"public"}]},"isi":1},{"date_published":"2018-02-07T00:00:00Z","date_updated":"2026-04-16T12:20:36Z","keyword":["microscopy","microfluidics"],"author":[{"full_name":"Bergmiller, Tobias","first_name":"Tobias","last_name":"Bergmiller","orcid":"0000-0001-5396-4346","id":"2C471CFA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Nikolic","first_name":"Nela","full_name":"Nikolic, Nela","orcid":"0000-0001-9068-6090","id":"42D9CABC-F248-11E8-B48F-1D18A9856A87"}],"year":"2018","related_material":{"record":[{"status":"public","relation":"research_paper","id":"438"}]},"_id":"5569","citation":{"ieee":"T. Bergmiller and N. Nikolic, “Time-lapse microscopy data.” Institute of Science and Technology Austria, 2018.","apa":"Bergmiller, T., &#38; Nikolic, N. (2018). Time-lapse microscopy data. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:74\">https://doi.org/10.15479/AT:ISTA:74</a>","ama":"Bergmiller T, Nikolic N. Time-lapse microscopy data. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:74\">10.15479/AT:ISTA:74</a>","mla":"Bergmiller, Tobias, and Nela Nikolic. <i>Time-Lapse Microscopy Data</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:74\">10.15479/AT:ISTA:74</a>.","short":"T. Bergmiller, N. Nikolic, (2018).","chicago":"Bergmiller, Tobias, and Nela Nikolic. “Time-Lapse Microscopy Data.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:74\">https://doi.org/10.15479/AT:ISTA:74</a>.","ista":"Bergmiller T, Nikolic N. 2018. Time-lapse microscopy data, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:74\">10.15479/AT:ISTA:74</a>."},"ddc":["579"],"publist_id":"7385","status":"public","datarep_id":"74","publisher":"Institute of Science and Technology Austria","file":[{"relation":"main_file","file_id":"5637","creator":"system","file_name":"IST-2018-74-v1+2_15-11-05.zip","date_created":"2018-12-12T13:04:39Z","date_updated":"2020-07-14T12:47:04Z","access_level":"open_access","checksum":"61ebb92213cfffeba3ddbaff984b81af","content_type":"application/zip","file_size":3558703796},{"creator":"system","file_name":"IST-2018-74-v1+3_15-07-31.zip","relation":"main_file","file_id":"5638","date_updated":"2020-07-14T12:47:04Z","access_level":"open_access","date_created":"2018-12-12T13:04:55Z","content_type":"application/zip","checksum":"bf26649af310ef6892d68576515cde6d","file_size":1830422606},{"file_id":"5639","relation":"main_file","file_name":"IST-2018-74-v1+4_Images_for_analysis.zip","creator":"system","file_size":2140849248,"content_type":"application/zip","checksum":"8e46eedce06f22acb2be1a9b9d3f56bd","date_created":"2018-12-12T13:05:11Z","date_updated":"2020-07-14T12:47:04Z","access_level":"open_access"}],"has_accepted_license":"1","oa_version":"Published Version","doi":"10.15479/AT:ISTA:74","date_created":"2018-12-12T12:31:35Z","article_processing_charge":"No","title":"Time-lapse microscopy data","department":[{"_id":"CaGu"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"07","tmp":{"legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","short":"CC0 (1.0)","image":"/images/cc_0.png","name":"Creative Commons Public Domain Dedication (CC0 1.0)"},"oa":1,"month":"02","type":"research_data","file_date_updated":"2020-07-14T12:47:04Z","abstract":[{"text":"Nela Nikolic, Tobias Bergmiller, Alexandra Vandervelde, Tanino G. Albanese, Lendert Gelens, and Isabella Moll (2018)\r\n“Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations” Nucleic Acids Research, doi: 10.15479/AT:ISTA:74;\r\nmicroscopy experiments by Tobias Bergmiller; image and data analysis by Nela Nikolic.","lang":"eng"}]},{"corr_author":"1","publication_identifier":{"issn":["2367-1726"],"eissn":["2367-1734"]},"project":[{"call_identifier":"FWF","grant_number":"M01980","name":"Robust Invariants of Nonlinear Systems","_id":"25F8B9BC-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","name":"FWF Open Access Fund","_id":"3AC91DDA-15DF-11EA-824D-93A3E7B544D1"}],"type":"journal_article","file_date_updated":"2020-07-14T12:47:40Z","month":"12","abstract":[{"lang":"eng","text":"A central problem of algebraic topology is to understand the homotopy groups  𝜋𝑑(𝑋)  of a topological space X. For the computational version of the problem, it is well known that there is no algorithm to decide whether the fundamental group  𝜋1(𝑋)  of a given finite simplicial complex X is trivial. On the other hand, there are several algorithms that, given a finite simplicial complex X that is simply connected (i.e., with   𝜋1(𝑋)  trivial), compute the higher homotopy group   𝜋𝑑(𝑋)  for any given   𝑑≥2 . However, these algorithms come with a caveat: They compute the isomorphism type of   𝜋𝑑(𝑋) ,   𝑑≥2  as an abstract finitely generated abelian group given by generators and relations, but they work with very implicit representations of the elements of   𝜋𝑑(𝑋) . Converting elements of this abstract group into explicit geometric maps from the d-dimensional sphere   𝑆𝑑  to X has been one of the main unsolved problems in the emerging field of computational homotopy theory. Here we present an algorithm that, given a simply connected space X, computes   𝜋𝑑(𝑋)  and represents its elements as simplicial maps from a suitable triangulation of the d-sphere   𝑆𝑑  to X. For fixed d, the algorithm runs in time exponential in   size(𝑋) , the number of simplices of X. Moreover, we prove that this is optimal: For every fixed   𝑑≥2 , we construct a family of simply connected spaces X such that for any simplicial map representing a generator of   𝜋𝑑(𝑋) , the size of the triangulation of   𝑆𝑑  on which the map is defined, is exponential in size(𝑋) ."}],"date_created":"2019-08-08T06:47:40Z","doi":"10.1007/s41468-018-0021-5","oa_version":"Published Version","title":"Computing simplicial representatives of homotopy group elements","department":[{"_id":"UlWa"}],"intvolume":"         2","publication_status":"published","language":[{"iso":"eng"}],"date_published":"2018-12-01T00:00:00Z","_id":"6774","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"6681"}]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"article_type":"original","quality_controlled":"1","issue":"3-4","volume":2,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"01","page":"177-231","ddc":["514"],"citation":{"ama":"Filakovský M, Franek P, Wagner U, Zhechev SY. Computing simplicial representatives of homotopy group elements. <i>Journal of Applied and Computational Topology</i>. 2018;2(3-4):177-231. doi:<a href=\"https://doi.org/10.1007/s41468-018-0021-5\">10.1007/s41468-018-0021-5</a>","apa":"Filakovský, M., Franek, P., Wagner, U., &#38; Zhechev, S. Y. (2018). Computing simplicial representatives of homotopy group elements. <i>Journal of Applied and Computational Topology</i>. Springer. <a href=\"https://doi.org/10.1007/s41468-018-0021-5\">https://doi.org/10.1007/s41468-018-0021-5</a>","mla":"Filakovský, Marek, et al. “Computing Simplicial Representatives of Homotopy Group Elements.” <i>Journal of Applied and Computational Topology</i>, vol. 2, no. 3–4, Springer, 2018, pp. 177–231, doi:<a href=\"https://doi.org/10.1007/s41468-018-0021-5\">10.1007/s41468-018-0021-5</a>.","ieee":"M. Filakovský, P. Franek, U. Wagner, and S. Y. Zhechev, “Computing simplicial representatives of homotopy group elements,” <i>Journal of Applied and Computational Topology</i>, vol. 2, no. 3–4. Springer, pp. 177–231, 2018.","chicago":"Filakovský, Marek, Peter Franek, Uli Wagner, and Stephan Y Zhechev. “Computing Simplicial Representatives of Homotopy Group Elements.” <i>Journal of Applied and Computational Topology</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s41468-018-0021-5\">https://doi.org/10.1007/s41468-018-0021-5</a>.","ista":"Filakovský M, Franek P, Wagner U, Zhechev SY. 2018. Computing simplicial representatives of homotopy group elements. Journal of Applied and Computational Topology. 2(3–4), 177–231.","short":"M. Filakovský, P. Franek, U. Wagner, S.Y. Zhechev, Journal of Applied and Computational Topology 2 (2018) 177–231."},"status":"public","publication":"Journal of Applied and Computational Topology","file":[{"relation":"main_file","file_id":"6775","creator":"dernst","file_name":"2018_JourAppliedComputTopology_Filakovsky.pdf","date_created":"2019-08-08T06:55:21Z","access_level":"open_access","date_updated":"2020-07-14T12:47:40Z","checksum":"cf9e7fcd2a113dd4828774fc75cdb7e8","file_size":1056278,"content_type":"application/pdf"}],"publisher":"Springer","has_accepted_license":"1","scopus_import":"1","date_updated":"2026-04-08T13:56:01Z","author":[{"id":"3E8AF77E-F248-11E8-B48F-1D18A9856A87","last_name":"Filakovský","first_name":"Marek","full_name":"Filakovský, Marek"},{"first_name":"Peter","last_name":"Franek","full_name":"Franek, Peter","id":"473294AE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8878-8397"},{"first_name":"Uli","last_name":"Wagner","full_name":"Wagner, Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1494-0568"},{"full_name":"Zhechev, Stephan Y","first_name":"Stephan Y","last_name":"Zhechev","id":"3AA52972-F248-11E8-B48F-1D18A9856A87"}],"year":"2018"},{"publist_id":"8002","publication_status":"published","language":[{"iso":"eng"}],"date_published":"2018-09-04T00:00:00Z","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"5856"},{"relation":"part_of_dissertation","id":"741","status":"public"},{"id":"1198","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","id":"154","status":"public"}]},"_id":"52","pubrep_id":"1043","corr_author":"1","publication_identifier":{"issn":["2663-337X"]},"project":[{"grant_number":"P27533_N27","name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems","_id":"25C878CE-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"abstract":[{"lang":"eng","text":"In this thesis we will discuss systems of point interacting fermions, their stability and other spectral properties. Whereas for bosons a point interacting system is always unstable this ques- tion is more subtle for a gas of two species of fermions. In particular the answer depends on the mass ratio between these two species. Most of this work will be focused on the N + M model which consists of two species of fermions with N, M particles respectively which interact via point interactions. We will introduce this model using a formal limit and discuss the N + 1 system in more detail. In particular, we will show that for mass ratios above a critical one, which does not depend on the particle number, the N + 1 system is stable. In the context of this model we will prove rigorous versions of Tan relations which relate various quantities of the point-interacting model. By restricting the N + 1 system to a box we define a finite density model with point in- teractions. In the context of this system we will discuss the energy change when introducing a point-interacting impurity into a system of non-interacting fermions. We will see that this change in energy is bounded independently of the particle number and in particular the bound only depends on the density and the scattering length. As another special case of the N + M model we will show stability of the 2 + 2 model for mass ratios in an interval around one. Further we will investigate a different model of point interactions which was discussed before in the literature and which is, contrary to the N + M model, not given by a limiting procedure but is based on a Dirichlet form. We will show that this system behaves trivially in the thermodynamic limit, i.e. the free energy per particle is the same as the one of the non-interacting system."}],"file_date_updated":"2020-07-14T12:46:37Z","month":"09","type":"dissertation","article_processing_charge":"No","oa_version":"Published Version","doi":"10.15479/AT:ISTA:th_1043","date_created":"2018-12-11T11:44:22Z","title":"Point interactions in systems of fermions","department":[{"_id":"RoSe"}],"degree_awarded":"PhD","page":"115","citation":{"short":"T. Moser, Point Interactions in Systems of Fermions, Institute of Science and Technology Austria, 2018.","ista":"Moser T. 2018. Point interactions in systems of fermions. Institute of Science and Technology Austria.","chicago":"Moser, Thomas. “Point Interactions in Systems of Fermions.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">https://doi.org/10.15479/AT:ISTA:th_1043</a>.","ama":"Moser T. Point interactions in systems of fermions. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">10.15479/AT:ISTA:th_1043</a>","ieee":"T. Moser, “Point interactions in systems of fermions,” Institute of Science and Technology Austria, 2018.","mla":"Moser, Thomas. <i>Point Interactions in Systems of Fermions</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">10.15479/AT:ISTA:th_1043</a>.","apa":"Moser, T. (2018). <i>Point interactions in systems of fermions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">https://doi.org/10.15479/AT:ISTA:th_1043</a>"},"ddc":["515","530","519"],"status":"public","has_accepted_license":"1","file":[{"content_type":"application/pdf","file_size":851164,"checksum":"fbd8c747d148b468a21213b7cf175225","date_updated":"2020-07-14T12:46:37Z","access_level":"open_access","date_created":"2019-04-09T07:45:38Z","file_name":"2018_Thesis_Moser.pdf","creator":"dernst","file_id":"6256","relation":"main_file"},{"checksum":"c28e16ecfc1126d3ce324ec96493c01e","content_type":"application/zip","file_size":1531516,"access_level":"closed","date_updated":"2020-07-14T12:46:37Z","date_created":"2019-04-09T07:45:38Z","creator":"dernst","file_name":"2018_Thesis_Moser_Source.zip","relation":"source_file","file_id":"6257"}],"publisher":"Institute of Science and Technology Austria","date_updated":"2026-04-16T12:20:40Z","year":"2018","author":[{"first_name":"Thomas","last_name":"Moser","full_name":"Moser, Thomas","id":"2B5FC9A4-F248-11E8-B48F-1D18A9856A87"}],"oa":1,"supervisor":[{"id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","first_name":"Robert","last_name":"Seiringer"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","alternative_title":["ISTA Thesis"],"day":"04"},{"language":[{"iso":"eng"}],"publist_id":"7767","publication_status":"published","intvolume":"        21","_id":"154","isi":1,"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"52"}]},"date_published":"2018-09-01T00:00:00Z","project":[{"call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","grant_number":"694227","name":"Analysis of quantum many-body systems"},{"call_identifier":"FWF","_id":"25C878CE-B435-11E9-9278-68D0E5697425","name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems","grant_number":"P27533_N27"},{"call_identifier":"FWF","name":"FWF Open Access Fund","_id":"3AC91DDA-15DF-11EA-824D-93A3E7B544D1"}],"external_id":{"isi":["000439639700001"]},"abstract":[{"text":"We give a lower bound on the ground state energy of a system of two fermions of one species interacting with two fermions of another species via point interactions. We show that there is a critical mass ratio m2 ≈ 0.58 such that the system is stable, i.e., the energy is bounded from below, for m∈[m2,m2−1]. So far it was not known whether this 2 + 2 system exhibits a stable region at all or whether the formation of four-body bound states causes an unbounded spectrum for all mass ratios, similar to the Thomas effect. Our result gives further evidence for the stability of the more general N + M system.","lang":"eng"}],"file_date_updated":"2020-07-14T12:45:01Z","month":"09","type":"journal_article","acknowledgement":"Open access funding provided by Austrian Science Fund (FWF).","publication_identifier":{"eissn":["1572-9656"],"issn":["1385-0172"]},"department":[{"_id":"RoSe"}],"article_processing_charge":"No","oa_version":"Published Version","doi":"10.1007/s11040-018-9275-3","date_created":"2018-12-11T11:44:55Z","title":"Stability of the 2+2 fermionic system with point interactions","scopus_import":"1","has_accepted_license":"1","ec_funded":1,"publisher":"Springer","file":[{"relation":"main_file","file_id":"5729","creator":"dernst","file_name":"2018_MathPhysics_Moser.pdf","content_type":"application/pdf","file_size":496973,"checksum":"411c4db5700d7297c9cd8ebc5dd29091","date_created":"2018-12-17T16:49:02Z","date_updated":"2020-07-14T12:45:01Z","access_level":"open_access"}],"article_number":"19","ddc":["530"],"citation":{"short":"T. Moser, R. Seiringer, Mathematical Physics Analysis and Geometry 21 (2018).","ista":"Moser T, Seiringer R. 2018. Stability of the 2+2 fermionic system with point interactions. Mathematical Physics Analysis and Geometry. 21(3), 19.","chicago":"Moser, Thomas, and Robert Seiringer. “Stability of the 2+2 Fermionic System with Point Interactions.” <i>Mathematical Physics Analysis and Geometry</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s11040-018-9275-3\">https://doi.org/10.1007/s11040-018-9275-3</a>.","ieee":"T. Moser and R. Seiringer, “Stability of the 2+2 fermionic system with point interactions,” <i>Mathematical Physics Analysis and Geometry</i>, vol. 21, no. 3. Springer, 2018.","apa":"Moser, T., &#38; Seiringer, R. (2018). Stability of the 2+2 fermionic system with point interactions. <i>Mathematical Physics Analysis and Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s11040-018-9275-3\">https://doi.org/10.1007/s11040-018-9275-3</a>","mla":"Moser, Thomas, and Robert Seiringer. “Stability of the 2+2 Fermionic System with Point Interactions.” <i>Mathematical Physics Analysis and Geometry</i>, vol. 21, no. 3, 19, Springer, 2018, doi:<a href=\"https://doi.org/10.1007/s11040-018-9275-3\">10.1007/s11040-018-9275-3</a>.","ama":"Moser T, Seiringer R. Stability of the 2+2 fermionic system with point interactions. <i>Mathematical Physics Analysis and Geometry</i>. 2018;21(3). doi:<a href=\"https://doi.org/10.1007/s11040-018-9275-3\">10.1007/s11040-018-9275-3</a>"},"status":"public","publication":"Mathematical Physics Analysis and Geometry","year":"2018","author":[{"last_name":"Moser","first_name":"Thomas","full_name":"Moser, Thomas","id":"2B5FC9A4-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","last_name":"Seiringer","full_name":"Seiringer, Robert"}],"date_updated":"2026-04-08T14:12:30Z","oa":1,"quality_controlled":"1","article_type":"original","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"01","issue":"3","volume":21},{"year":"2018","author":[{"full_name":"Groever, Benedikt","first_name":"Benedikt","last_name":"Groever"},{"id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","full_name":"Roques-Carmes, Charles","first_name":"Charles","last_name":"Roques-Carmes"},{"first_name":"Steven J.","last_name":"Byrnes","full_name":"Byrnes, Steven J."},{"full_name":"Capasso, Federico","first_name":"Federico","last_name":"Capasso"}],"date_updated":"2026-04-27T08:41:20Z","extern":"1","scopus_import":"1","publisher":"Optica Publishing Group","publication":"Applied Optics","status":"public","OA_type":"closed access","ddc":["530"],"citation":{"ista":"Groever B, Roques-Carmes C, Byrnes SJ, Capasso F. 2018. Substrate aberration and correction for meta-lens imaging: An analytical approach. Applied Optics. 57(12), 2973–2980.","short":"B. Groever, C. Roques-Carmes, S.J. Byrnes, F. Capasso, Applied Optics 57 (2018) 2973–2980.","chicago":"Groever, Benedikt, Charles Roques-Carmes, Steven J. Byrnes, and Federico Capasso. “Substrate Aberration and Correction for Meta-Lens Imaging: An Analytical Approach.” <i>Applied Optics</i>. Optica Publishing Group, 2018. <a href=\"https://doi.org/10.1364/ao.57.002973\">https://doi.org/10.1364/ao.57.002973</a>.","ieee":"B. Groever, C. Roques-Carmes, S. J. Byrnes, and F. Capasso, “Substrate aberration and correction for meta-lens imaging: An analytical approach,” <i>Applied Optics</i>, vol. 57, no. 12. Optica Publishing Group, pp. 2973–2980, 2018.","apa":"Groever, B., Roques-Carmes, C., Byrnes, S. J., &#38; Capasso, F. (2018). Substrate aberration and correction for meta-lens imaging: An analytical approach. <i>Applied Optics</i>. Optica Publishing Group. <a href=\"https://doi.org/10.1364/ao.57.002973\">https://doi.org/10.1364/ao.57.002973</a>","mla":"Groever, Benedikt, et al. “Substrate Aberration and Correction for Meta-Lens Imaging: An Analytical Approach.” <i>Applied Optics</i>, vol. 57, no. 12, Optica Publishing Group, 2018, pp. 2973–80, doi:<a href=\"https://doi.org/10.1364/ao.57.002973\">10.1364/ao.57.002973</a>.","ama":"Groever B, Roques-Carmes C, Byrnes SJ, Capasso F. Substrate aberration and correction for meta-lens imaging: An analytical approach. <i>Applied Optics</i>. 2018;57(12):2973-2980. doi:<a href=\"https://doi.org/10.1364/ao.57.002973\">10.1364/ao.57.002973</a>"},"page":"2973-2980","day":"12","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","volume":57,"issue":"12","quality_controlled":"1","article_type":"original","_id":"21587","date_published":"2018-04-12T00:00:00Z","language":[{"iso":"eng"}],"publication_status":"published","intvolume":"        57","pmid":1,"title":"Substrate aberration and correction for meta-lens imaging: An analytical approach","article_processing_charge":"No","date_created":"2026-03-30T12:22:48Z","doi":"10.1364/ao.57.002973","oa_version":"None","abstract":[{"text":"Meta-lenses based on flat optics enabled a fundamental shift in lens production—providing an easier manufacturing process with an increase in lens profile precision and a reduction in size and weight. Here we present an analytical approach to correct spherical aberrations caused by light propagation through the substrate by adding a substrate-corrected phase profile, which differs from the original hyperbolic one. A meta-lens encoding the new phase profile would yield diffraction-limited focusing and an increase of up to 0.3 of its numerical aperture without changing the radius or focal length. In tightly focused laser spot applications such as direct laser lithography and laser printing, a substrate-corrected meta-lens can reduce the spatial footprint of the meta-lens.","lang":"eng"}],"month":"04","type":"journal_article","external_id":{"pmid":[" 29714325"]},"publication_identifier":{"issn":["1559-128X"],"eissn":["2155-3165"]}},{"title":"Auxin methylation is required for differential growth in Arabidopsis","doi":"10.1073/pnas.1806565115","date_created":"2018-12-11T11:45:11Z","oa_version":"Submitted Version","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"http://eprints.nottingham.ac.uk/52388/"}],"department":[{"_id":"JiFr"}],"type":"journal_article","month":"06","abstract":[{"text":"Asymmetric auxin distribution is instrumental for the differential growth that causes organ bending on tropic stimuli and curvatures during plant development. Local differences in auxin concentrations are achieved mainly by polarized cellular distribution of PIN auxin transporters, but whether other mechanisms involving auxin homeostasis are also relevant for the formation of auxin gradients is not clear. Here we show that auxin methylation is required for asymmetric auxin distribution across the hypocotyl, particularly during its response to gravity. We found that loss-of-function mutants in Arabidopsis IAA CARBOXYL METHYLTRANSFERASE1 (IAMT1) prematurely unfold the apical hook, and that their hypocotyls are impaired in gravitropic reorientation. This defect is linked to an auxin-dependent increase in PIN gene expression, leading to an increased polar auxin transport and lack of asymmetric distribution of PIN3 in the iamt1 mutant. Gravitropic reorientation in the iamt1 mutant could be restored with either endodermis-specific expression of IAMT1 or partial inhibition of polar auxin transport, which also results in normal PIN gene expression levels. We propose that IAA methylation is necessary in gravity-sensing cells to restrict polar auxin transport within the range of auxin levels that allow for differential responses.","lang":"eng"}],"external_id":{"isi":["000436245000096"]},"project":[{"call_identifier":"FP7","_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants","grant_number":"282300"}],"date_published":"2018-06-26T00:00:00Z","_id":"203","isi":1,"intvolume":"       115","publication_status":"published","publist_id":"7710","language":[{"iso":"eng"}],"volume":115,"issue":"26","day":"26","OA_place":"repository","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","quality_controlled":"1","oa":1,"date_updated":"2026-04-28T08:29:26Z","author":[{"id":"47E8FC1C-F248-11E8-B48F-1D18A9856A87","full_name":"Abbas, Mohamad","first_name":"Mohamad","last_name":"Abbas"},{"full_name":"Hernández, García J","last_name":"Hernández","first_name":"García J"},{"full_name":"Pollmann, Stephan","first_name":"Stephan","last_name":"Pollmann"},{"full_name":"Samodelov, Sophia L","first_name":"Sophia L","last_name":"Samodelov"},{"full_name":"Kolb, Martina","last_name":"Kolb","first_name":"Martina"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jirí","full_name":"Friml, Jirí"},{"last_name":"Hammes","first_name":"Ulrich Z","full_name":"Hammes, Ulrich Z"},{"full_name":"Zurbriggen, Matias D","first_name":"Matias D","last_name":"Zurbriggen"},{"full_name":"Blázquez, Miguel","last_name":"Blázquez","first_name":"Miguel"},{"full_name":"Alabadí, David","last_name":"Alabadí","first_name":"David"}],"year":"2018","status":"public","publication":"PNAS","page":"6864-6869","citation":{"ama":"Abbas M, Hernández GJ, Pollmann S, et al. Auxin methylation is required for differential growth in Arabidopsis. <i>PNAS</i>. 2018;115(26):6864-6869. doi:<a href=\"https://doi.org/10.1073/pnas.1806565115\">10.1073/pnas.1806565115</a>","mla":"Abbas, Mohamad, et al. “Auxin Methylation Is Required for Differential Growth in Arabidopsis.” <i>PNAS</i>, vol. 115, no. 26, National Academy of Sciences, 2018, pp. 6864–69, doi:<a href=\"https://doi.org/10.1073/pnas.1806565115\">10.1073/pnas.1806565115</a>.","apa":"Abbas, M., Hernández, G. J., Pollmann, S., Samodelov, S. L., Kolb, M., Friml, J., … Alabadí, D. (2018). Auxin methylation is required for differential growth in Arabidopsis. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1806565115\">https://doi.org/10.1073/pnas.1806565115</a>","ieee":"M. Abbas <i>et al.</i>, “Auxin methylation is required for differential growth in Arabidopsis,” <i>PNAS</i>, vol. 115, no. 26. National Academy of Sciences, pp. 6864–6869, 2018.","short":"M. Abbas, G.J. Hernández, S. Pollmann, S.L. Samodelov, M. Kolb, J. Friml, U.Z. Hammes, M.D. Zurbriggen, M. Blázquez, D. Alabadí, PNAS 115 (2018) 6864–6869.","ista":"Abbas M, Hernández GJ, Pollmann S, Samodelov SL, Kolb M, Friml J, Hammes UZ, Zurbriggen MD, Blázquez M, Alabadí D. 2018. Auxin methylation is required for differential growth in Arabidopsis. PNAS. 115(26), 6864–6869.","chicago":"Abbas, Mohamad, García J Hernández, Stephan Pollmann, Sophia L Samodelov, Martina Kolb, Jiří Friml, Ulrich Z Hammes, Matias D Zurbriggen, Miguel Blázquez, and David Alabadí. “Auxin Methylation Is Required for Differential Growth in Arabidopsis.” <i>PNAS</i>. National Academy of Sciences, 2018. <a href=\"https://doi.org/10.1073/pnas.1806565115\">https://doi.org/10.1073/pnas.1806565115</a>."},"OA_type":"green","publisher":"National Academy of Sciences","ec_funded":1,"scopus_import":"1"},{"has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","file":[{"embargo_to":"open_access","date_created":"2019-04-05T09:23:11Z","date_updated":"2021-02-11T23:30:17Z","access_level":"closed","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_size":29027671,"checksum":"d5e3edbac548c26c1fa43a4b37a54a4c","relation":"source_file","file_id":"6219","creator":"dernst","file_name":"PhD_thesis_AlexLeithner_final_version.docx"},{"date_created":"2019-04-05T09:23:11Z","date_updated":"2021-02-11T11:17:16Z","access_level":"open_access","checksum":"071f7476db29e41146824ebd0697cb10","content_type":"application/pdf","file_size":66045341,"file_id":"6220","relation":"main_file","embargo":"2019-04-15","file_name":"PhD_thesis_AlexLeithner.pdf","creator":"dernst"}],"citation":{"apa":"Leithner, A. F. (2018). <i>Branched actin networks in dendritic cell biology</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_998\">https://doi.org/10.15479/AT:ISTA:th_998</a>","ieee":"A. F. Leithner, “Branched actin networks in dendritic cell biology,” Institute of Science and Technology Austria, 2018.","mla":"Leithner, Alexander F. <i>Branched Actin Networks in Dendritic Cell Biology</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_998\">10.15479/AT:ISTA:th_998</a>.","ama":"Leithner AF. Branched actin networks in dendritic cell biology. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_998\">10.15479/AT:ISTA:th_998</a>","short":"A.F. Leithner, Branched Actin Networks in Dendritic Cell Biology, Institute of Science and Technology Austria, 2018.","ista":"Leithner AF. 2018. Branched actin networks in dendritic cell biology. Institute of Science and Technology Austria.","chicago":"Leithner, Alexander F. “Branched Actin Networks in Dendritic Cell Biology.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_998\">https://doi.org/10.15479/AT:ISTA:th_998</a>."},"ddc":["571","599","610"],"page":"99","status":"public","year":"2018","author":[{"full_name":"Leithner, Alexander F","first_name":"Alexander F","last_name":"Leithner","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1073-744X"}],"acknowledged_ssus":[{"_id":"NanoFab"},{"_id":"Bio"},{"_id":"PreCl"},{"_id":"EM-Fac"}],"date_updated":"2025-09-22T08:27:34Z","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","alternative_title":["ISTA Thesis"],"day":"12","supervisor":[{"first_name":"Michael K","last_name":"Sixt","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179"}],"language":[{"iso":"eng"}],"publist_id":"7542","publication_status":"published","related_material":{"record":[{"relation":"part_of_dissertation","id":"1321","status":"public"}]},"_id":"323","date_published":"2018-04-12T00:00:00Z","abstract":[{"lang":"eng","text":"In the here presented thesis, we explore the role of branched actin networks in cell migration and antigen presentation, the two most relevant processes in dendritic cell biology. Branched actin networks construct lamellipodial protrusions at the leading edge of migrating cells. These are typically seen as adhesive structures, which mediate force transduction to the extracellular matrix that leads to forward locomotion. We ablated Arp2/3 nucleation promoting factor WAVE in DCs and found that the resulting cells lack lamellipodial protrusions. Instead, depending on the maturation state, one or multiple filopodia were formed. By challenging these cells in a variety of migration assays we found that lamellipodial protrusions are dispensable for the locomotion of leukocytes and actually dampen the speed of migration. However, lamellipodia are critically required to negotiate complex environments that DCs experience while they travel to the next draining lymph node. Taken together our results suggest that leukocyte lamellipodia have rather a sensory- than a force transducing function. Furthermore, we show for the first time structure and dynamics of dendritic cell F-actin at the immunological synapse with naïve T cells. Dendritic cell F-actin appears as dynamic foci that are nucleated by the Arp2/3 complex. WAVE ablated dendritic cells show increased membrane tension, leading to an altered ultrastructure of the immunological synapse and severe T cell priming defects. These results point towards a previously unappreciated role of the cellular mechanics of dendritic cells in T cell activation. Additionally, we present a novel cell culture based system for the differentiation of dendritic cells from conditionally immortalized hematopoietic precursors. These precursor cells are genetically tractable via the CRISPR/Cas9 system while they retain their ability to differentiate into highly migratory dendritic cells and other immune cells. This will foster the study of all aspects of dendritic cell biology and beyond. "}],"type":"dissertation","month":"04","file_date_updated":"2021-02-11T23:30:17Z","corr_author":"1","pubrep_id":"998","acknowledgement":"First of all I would like to thank Michael Sixt for giving me the opportunity to work in \r\nhis group and for his support throughout the years. He is a truly inspiring person and \r\nthe  best  boss  one  can  imagine.  I  would  also  like  to  thank  all  current  and  past \r\nmembers of the Sixt group for their help and the great working atmosphere in the lab. \r\nIt is a true privilege to work with such a bright, funny and friendly group of people and \r\nI’m  proud  that  I  could  be  part  of  it.  Furthermore,  I  would  like  to  say  ‘thank  you’  to Daria Siekhaus for all the meetings and discussion we had throughout the years \r\nand to  Federica  Benvenuti  for  being  part  of  my  committee.  I  am  also  grateful  to  Jack \r\nMerrin  in  the  nanofabrication  facility  and  all  the  people  working  in  the  bioimaging-\r\n, the electron microscopy- and the preclinical facilities.","publication_identifier":{"issn":["2663-337X"]},"department":[{"_id":"MiSi"}],"degree_awarded":"PhD","article_processing_charge":"No","oa_version":"Published Version","date_created":"2018-12-11T11:45:49Z","doi":"10.15479/AT:ISTA:th_998","title":"Branched actin networks in dendritic cell biology"},{"intvolume":"       208","publication_status":"published","publist_id":"7274","language":[{"iso":"eng"}],"date_published":"2018-01-01T00:00:00Z","related_material":{"record":[{"relation":"popular_science","id":"5571","status":"public"},{"id":"5572","relation":"popular_science","status":"public"},{"status":"public","id":"17119","relation":"dissertation_contains"}]},"_id":"542","isi":1,"pubrep_id":"1058","corr_author":"1","file_date_updated":"2020-07-14T12:46:50Z","month":"01","type":"journal_article","abstract":[{"lang":"eng","text":"The t-haplotype, a mouse meiotic driver found on chromosome 17, has been a model for autosomal segregation distortion for close to a century, but several questions remain regarding its biology and evolutionary history. A recently published set of population genomics resources for wild mice includes several individuals heterozygous for the t-haplotype, which we use to characterize this selfish element at the genomic and transcriptomic level. Our results show that large sections of the t-haplotype have been replaced by standard homologous sequences, possibly due to occasional events of recombination, and that this complicates the inference of its history. As expected for a long genomic segment of very low recombination, the t-haplotype carries an excess of fixed nonsynonymous mutations compared to the standard chromosome. This excess is stronger for regions that have not undergone recent recombination, suggesting that occasional gene flow between the t and the standard chromosome may provide a mechanism to regenerate coding sequences that have accumulated deleterious mutations. Finally, we find that t-complex genes with altered expression largely overlap with deleted or amplified regions, and that carrying a t-haplotype alters the testis expression of genes outside of the t-complex, providing new leads into the pathways involved in the biology of this segregation distorter."}],"external_id":{"isi":["000419356300024"]},"project":[{"_id":"250BDE62-B435-11E9-9278-68D0E5697425","grant_number":"715257","name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","call_identifier":"H2020"}],"title":"Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver","oa_version":"Published Version","date_created":"2018-12-11T11:47:04Z","doi":"10.1534/genetics.117.300513","article_processing_charge":"No","department":[{"_id":"BeVi"}],"publication":"Genetics","status":"public","page":"365 - 375","ddc":["576"],"citation":{"ieee":"R. K. Kelemen and B. Vicoso, “Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver,” <i>Genetics</i>, vol. 208, no. 1. Genetics Society of America, pp. 365–375, 2018.","mla":"Kelemen, Réka K., and Beatriz Vicoso. “Complex History and Differentiation Patterns of the T-Haplotype, a Mouse Meiotic Driver.” <i>Genetics</i>, vol. 208, no. 1, Genetics Society of America, 2018, pp. 365–75, doi:<a href=\"https://doi.org/10.1534/genetics.117.300513\">10.1534/genetics.117.300513</a>.","ama":"Kelemen RK, Vicoso B. Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver. <i>Genetics</i>. 2018;208(1):365-375. doi:<a href=\"https://doi.org/10.1534/genetics.117.300513\">10.1534/genetics.117.300513</a>","apa":"Kelemen, R. K., &#38; Vicoso, B. (2018). Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.117.300513\">https://doi.org/10.1534/genetics.117.300513</a>","chicago":"Kelemen, Réka K, and Beatriz Vicoso. “Complex History and Differentiation Patterns of the T-Haplotype, a Mouse Meiotic Driver.” <i>Genetics</i>. Genetics Society of America, 2018. <a href=\"https://doi.org/10.1534/genetics.117.300513\">https://doi.org/10.1534/genetics.117.300513</a>.","ista":"Kelemen RK, Vicoso B. 2018. Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver. Genetics. 208(1), 365–375.","short":"R.K. Kelemen, B. Vicoso, Genetics 208 (2018) 365–375."},"publisher":"Genetics Society of America","file":[{"date_created":"2018-12-12T10:15:14Z","date_updated":"2020-07-14T12:46:50Z","access_level":"open_access","file_size":1311661,"checksum":"2123845e7031a0cf043905be160f9e69","content_type":"application/pdf","relation":"main_file","file_id":"5132","creator":"system","file_name":"IST-2018-1058-v1+1_365.full__1_.pdf"}],"has_accepted_license":"1","scopus_import":"1","ec_funded":1,"date_updated":"2026-04-29T22:30:15Z","author":[{"id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8489-9281","full_name":"Kelemen, Réka K","last_name":"Kelemen","first_name":"Réka K"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","first_name":"Beatriz","last_name":"Vicoso"}],"year":"2018","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","quality_controlled":"1","oa":1,"volume":208,"issue":"1","day":"01","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"PreCl"}],"date_updated":"2026-04-29T22:30:32Z","year":"2018","author":[{"id":"37A40D7E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7370-5293","full_name":"Deliu, Elena","first_name":"Elena","last_name":"Deliu"},{"full_name":"Arecco, Niccoló","first_name":"Niccoló","last_name":"Arecco"},{"first_name":"Jasmin","last_name":"Morandell","full_name":"Morandell, Jasmin","id":"4739D480-F248-11E8-B48F-1D18A9856A87"},{"id":"4C66542E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9033-9096","full_name":"Dotter, Christoph","last_name":"Dotter","first_name":"Christoph"},{"id":"475990FE-F248-11E8-B48F-1D18A9856A87","full_name":"Contreras, Ximena","first_name":"Ximena","last_name":"Contreras"},{"last_name":"Girardot","first_name":"Charles","full_name":"Girardot, Charles"},{"last_name":"Käsper","first_name":"Eva","full_name":"Käsper, Eva"},{"id":"C50A9596-02D0-11E9-976E-E38CFE5CBC1D","full_name":"Kozlova, Alena","first_name":"Alena","last_name":"Kozlova"},{"last_name":"Kishi","first_name":"Kasumi","full_name":"Kishi, Kasumi","orcid":"0000-0001-6060-4795","id":"3065DFC4-F248-11E8-B48F-1D18A9856A87"},{"id":"B6467F20-02D0-11E9-BDA5-E960C241894A","orcid":"0000-0002-9529-4464","full_name":"Chiaradia, Ilaria","last_name":"Chiaradia","first_name":"Ilaria"},{"last_name":"Noh","first_name":"Kyung","full_name":"Noh, Kyung"},{"last_name":"Novarino","first_name":"Gaia","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"}],"page":"1717 - 1727","citation":{"mla":"Deliu, Elena, et al. “Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature Neuroscience</i>, vol. 21, no. 12, Nature Publishing Group, 2018, pp. 1717–27, doi:<a href=\"https://doi.org/10.1038/s41593-018-0266-2\">10.1038/s41593-018-0266-2</a>.","apa":"Deliu, E., Arecco, N., Morandell, J., Dotter, C., Contreras, X., Girardot, C., … Novarino, G. (2018). Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41593-018-0266-2\">https://doi.org/10.1038/s41593-018-0266-2</a>","ama":"Deliu E, Arecco N, Morandell J, et al. Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. <i>Nature Neuroscience</i>. 2018;21(12):1717-1727. doi:<a href=\"https://doi.org/10.1038/s41593-018-0266-2\">10.1038/s41593-018-0266-2</a>","ieee":"E. Deliu <i>et al.</i>, “Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition,” <i>Nature Neuroscience</i>, vol. 21, no. 12. Nature Publishing Group, pp. 1717–1727, 2018.","chicago":"Deliu, Elena, Niccoló Arecco, Jasmin Morandell, Christoph Dotter, Ximena Contreras, Charles Girardot, Eva Käsper, et al. “Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41593-018-0266-2\">https://doi.org/10.1038/s41593-018-0266-2</a>.","ista":"Deliu E, Arecco N, Morandell J, Dotter C, Contreras X, Girardot C, Käsper E, Kozlova A, Kishi K, Chiaradia I, Noh K, Novarino G. 2018. Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. Nature Neuroscience. 21(12), 1717–1727.","short":"E. Deliu, N. Arecco, J. Morandell, C. Dotter, X. Contreras, C. Girardot, E. Käsper, A. Kozlova, K. Kishi, I. Chiaradia, K. Noh, G. Novarino, Nature Neuroscience 21 (2018) 1717–1727."},"ddc":["570"],"publication":"Nature Neuroscience","status":"public","scopus_import":"1","has_accepted_license":"1","file":[{"content_type":"application/pdf","file_size":8167169,"checksum":"60abd0f05b7cdc08a6b0ec460884084f","date_created":"2019-04-09T07:41:57Z","access_level":"open_access","date_updated":"2020-07-14T12:45:58Z","relation":"main_file","file_id":"6255","creator":"dernst","file_name":"2017_NatureNeuroscience_Deliu.pdf"}],"publisher":"Nature Publishing Group","issue":"12","volume":21,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","day":"19","oa":1,"quality_controlled":"1","article_type":"original","date_published":"2018-11-19T00:00:00Z","related_material":{"record":[{"status":"public","id":"6074","relation":"popular_science"},{"relation":"dissertation_contains","id":"12364","status":"public"}],"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/mutation-that-causes-autism-and-intellectual-disability-makes-brain-less-flexible/"}]},"_id":"3","isi":1,"publist_id":"8054","publication_status":"published","intvolume":"        21","language":[{"iso":"eng"}],"article_processing_charge":"No","oa_version":"Submitted Version","doi":"10.1038/s41593-018-0266-2","date_created":"2018-12-11T11:44:05Z","title":"Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition","department":[{"_id":"GaNo"},{"_id":"EdHa"}],"corr_author":"1","pubrep_id":"1071","acknowledgement":"This work was supported by the Simons Foundation Autism Research Initiative (grant 401299) to G.N. and the DFG (SPP1738 grant NO 1249) to K.-M.N.","project":[{"_id":"254BA948-B435-11E9-9278-68D0E5697425","name":"Probing development and reversibility of autism spectrum disorders","grant_number":"401299"}],"external_id":{"isi":["000451324700010"]},"abstract":[{"text":"SETD5 gene mutations have been identified as a frequent cause of idiopathic intellectual disability. Here we show that Setd5-haploinsufficient mice present developmental defects such as abnormal brain-to-body weight ratios and neural crest defect-associated phenotypes. Furthermore, Setd5-mutant mice show impairments in cognitive tasks, enhanced long-term potentiation, delayed ontogenetic profile of ultrasonic vocalization, and behavioral inflexibility. Behavioral issues are accompanied by abnormal expression of postsynaptic density proteins previously associated with cognition. Our data additionally indicate that Setd5 regulates RNA polymerase II dynamics and gene transcription via its interaction with the Hdac3 and Paf1 complexes, findings potentially explaining the gene expression defects observed in Setd5-haploinsufficient mice. Our results emphasize the decisive role of Setd5 in a biological pathway found to be disrupted in humans with intellectual disability and autism spectrum disorder.","lang":"eng"}],"type":"journal_article","month":"11","file_date_updated":"2020-07-14T12:45:58Z"},{"pmid":1,"publist_id":"8040","publication_status":"published","intvolume":"        19","language":[{"iso":"eng"}],"date_published":"2018-05-18T00:00:00Z","isi":1,"_id":"15","related_material":{"record":[{"status":"public","id":"6891","relation":"dissertation_contains"}]},"acknowledgement":"This work was funded by grants from the European Research Council (ERC StG 281556 and CoG 724373) and the Austrian Science Foundation (FWF) to M.S. and by Swiss National Foundation (SNF) project grants 31003A_135649, 31003A_153457 and CR23I3_156234 to J.V.S. F.G. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 747687, and J.R. was funded by an EMBO long-term fellowship (ALTF 1396-2014).","project":[{"_id":"25FE9508-B435-11E9-9278-68D0E5697425","grant_number":"724373","name":"Cellular Navigation Along Spatial Gradients","call_identifier":"H2020"},{"call_identifier":"H2020","_id":"260AA4E2-B435-11E9-9278-68D0E5697425","name":"Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells","grant_number":"747687"},{"_id":"25A48D24-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 1396-2014","name":"Molecular and system level view of immune cell migration"},{"_id":"25A603A2-B435-11E9-9278-68D0E5697425","grant_number":"281556","name":"Cytoskeletal force generation and force transduction of migrating leukocytes","call_identifier":"FP7"}],"external_id":{"pmid":["29777221"],"isi":["000433041500026"]},"abstract":[{"text":"Although much is known about the physiological framework of T cell motility, and numerous rate-limiting molecules have been identified through loss-of-function approaches, an integrated functional concept of T cell motility is lacking. Here, we used in vivo precision morphometry together with analysis of cytoskeletal dynamics in vitro to deconstruct the basic mechanisms of T cell migration within lymphatic organs. We show that the contributions of the integrin LFA-1 and the chemokine receptor CCR7 are complementary rather than positioned in a linear pathway, as they are during leukocyte extravasation from the blood vasculature. Our data demonstrate that CCR7 controls cortical actin flows, whereas integrins mediate substrate friction that is sufficient to drive locomotion in the absence of considerable surface adhesions and plasma membrane flux.","lang":"eng"}],"type":"journal_article","month":"05","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pubmed/29777221"}],"article_processing_charge":"No","oa_version":"Published Version","doi":"10.1038/s41590-018-0109-z","date_created":"2018-12-11T11:44:10Z","title":"Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells","department":[{"_id":"MiSi"},{"_id":"Bio"}],"page":"606 - 616","citation":{"ista":"Hons M, Kopf A, Hauschild R, Leithner AF, Gärtner FR, Abe J, Renkawitz J, Stein J, Sixt MK. 2018. Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. Nature Immunology. 19(6), 606–616.","chicago":"Hons, Miroslav, Aglaja Kopf, Robert Hauschild, Alexander F Leithner, Florian R Gärtner, Jun Abe, Jörg Renkawitz, Jens Stein, and Michael K Sixt. “Chemokines and Integrins Independently Tune Actin Flow and Substrate Friction during Intranodal Migration of T Cells.” <i>Nature Immunology</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41590-018-0109-z\">https://doi.org/10.1038/s41590-018-0109-z</a>.","short":"M. Hons, A. Kopf, R. Hauschild, A.F. Leithner, F.R. Gärtner, J. Abe, J. Renkawitz, J. Stein, M.K. Sixt, Nature Immunology 19 (2018) 606–616.","mla":"Hons, Miroslav, et al. “Chemokines and Integrins Independently Tune Actin Flow and Substrate Friction during Intranodal Migration of T Cells.” <i>Nature Immunology</i>, vol. 19, no. 6, Nature Publishing Group, 2018, pp. 606–16, doi:<a href=\"https://doi.org/10.1038/s41590-018-0109-z\">10.1038/s41590-018-0109-z</a>.","ama":"Hons M, Kopf A, Hauschild R, et al. Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. <i>Nature Immunology</i>. 2018;19(6):606-616. doi:<a href=\"https://doi.org/10.1038/s41590-018-0109-z\">10.1038/s41590-018-0109-z</a>","ieee":"M. Hons <i>et al.</i>, “Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells,” <i>Nature Immunology</i>, vol. 19, no. 6. Nature Publishing Group, pp. 606–616, 2018.","apa":"Hons, M., Kopf, A., Hauschild, R., Leithner, A. F., Gärtner, F. R., Abe, J., … Sixt, M. K. (2018). Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. <i>Nature Immunology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41590-018-0109-z\">https://doi.org/10.1038/s41590-018-0109-z</a>"},"publication":"Nature Immunology","status":"public","ec_funded":1,"scopus_import":"1","publisher":"Nature Publishing Group","acknowledged_ssus":[{"_id":"SSU"}],"date_updated":"2026-04-29T22:30:36Z","year":"2018","author":[{"id":"4167FE56-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6625-3348","full_name":"Hons, Miroslav","first_name":"Miroslav","last_name":"Hons"},{"id":"31DAC7B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2187-6656","full_name":"Kopf, Aglaja","last_name":"Kopf","first_name":"Aglaja"},{"full_name":"Hauschild, Robert","last_name":"Hauschild","first_name":"Robert","orcid":"0000-0001-9843-3522","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Leithner","first_name":"Alexander F","full_name":"Leithner, Alexander F","orcid":"0000-0002-1073-744X","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Florian R","last_name":"Gärtner","full_name":"Gärtner, Florian R","orcid":"0000-0001-6120-3723","id":"397A88EE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Abe","first_name":"Jun","full_name":"Abe, Jun"},{"full_name":"Renkawitz, Jörg","first_name":"Jörg","last_name":"Renkawitz","id":"3F0587C8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2856-3369"},{"full_name":"Stein, Jens","first_name":"Jens","last_name":"Stein"},{"full_name":"Sixt, Michael K","first_name":"Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"oa":1,"quality_controlled":"1","issue":"6","volume":19,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","day":"18"},{"quality_controlled":"1","oa":1,"day":"27","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","volume":115,"issue":"48","publisher":"National Academy of Sciences","ec_funded":1,"scopus_import":"1","publication":"PNAS","status":"public","citation":{"short":"C. Hilbe, L. Schmid, J. Tkadlec, K. Chatterjee, M. Nowak, PNAS 115 (2018) 12241–12246.","chicago":"Hilbe, Christian, Laura Schmid, Josef Tkadlec, Krishnendu Chatterjee, and Martin Nowak. “Indirect Reciprocity with Private, Noisy, and Incomplete Information.” <i>PNAS</i>. National Academy of Sciences, 2018. <a href=\"https://doi.org/10.1073/pnas.1810565115\">https://doi.org/10.1073/pnas.1810565115</a>.","ista":"Hilbe C, Schmid L, Tkadlec J, Chatterjee K, Nowak M. 2018. Indirect reciprocity with private, noisy, and incomplete information. PNAS. 115(48), 12241–12246.","mla":"Hilbe, Christian, et al. “Indirect Reciprocity with Private, Noisy, and Incomplete Information.” <i>PNAS</i>, vol. 115, no. 48, National Academy of Sciences, 2018, pp. 12241–46, doi:<a href=\"https://doi.org/10.1073/pnas.1810565115\">10.1073/pnas.1810565115</a>.","ieee":"C. Hilbe, L. Schmid, J. Tkadlec, K. Chatterjee, and M. Nowak, “Indirect reciprocity with private, noisy, and incomplete information,” <i>PNAS</i>, vol. 115, no. 48. National Academy of Sciences, pp. 12241–12246, 2018.","ama":"Hilbe C, Schmid L, Tkadlec J, Chatterjee K, Nowak M. Indirect reciprocity with private, noisy, and incomplete information. <i>PNAS</i>. 2018;115(48):12241-12246. doi:<a href=\"https://doi.org/10.1073/pnas.1810565115\">10.1073/pnas.1810565115</a>","apa":"Hilbe, C., Schmid, L., Tkadlec, J., Chatterjee, K., &#38; Nowak, M. (2018). Indirect reciprocity with private, noisy, and incomplete information. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1810565115\">https://doi.org/10.1073/pnas.1810565115</a>"},"page":"12241-12246","author":[{"orcid":"0000-0001-5116-955X","id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87","full_name":"Hilbe, Christian","first_name":"Christian","last_name":"Hilbe"},{"orcid":"0000-0002-6978-7329","id":"38B437DE-F248-11E8-B48F-1D18A9856A87","full_name":"Schmid, Laura","first_name":"Laura","last_name":"Schmid"},{"id":"3F24CCC8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1097-9684","full_name":"Tkadlec, Josef","last_name":"Tkadlec","first_name":"Josef"},{"orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu"},{"full_name":"Nowak, Martin","first_name":"Martin","last_name":"Nowak"}],"year":"2018","date_updated":"2026-04-29T22:30:38Z","month":"11","type":"journal_article","abstract":[{"text":"Indirect reciprocity explores how humans act when their reputation is at stake, and which social norms they use to assess the actions of others. A crucial question in indirect reciprocity is which social norms can maintain stable cooperation in a society. Past research has highlighted eight such norms, called “leading-eight” strategies. This past research, however, is based on the assumption that all relevant information about other population members is publicly available and that everyone agrees on who is good or bad. Instead, here we explore the reputation dynamics when information is private and noisy. We show that under these conditions, most leading-eight strategies fail to evolve. Those leading-eight strategies that do evolve are unable to sustain full cooperation.Indirect reciprocity is a mechanism for cooperation based on shared moral systems and individual reputations. It assumes that members of a community routinely observe and assess each other and that they use this information to decide who is good or bad, and who deserves cooperation. When information is transmitted publicly, such that all community members agree on each other’s reputation, previous research has highlighted eight crucial moral systems. These “leading-eight” strategies can maintain cooperation and resist invasion by defectors. However, in real populations individuals often hold their own private views of others. Once two individuals disagree about their opinion of some third party, they may also see its subsequent actions in a different light. Their opinions may further diverge over time. Herein, we explore indirect reciprocity when information transmission is private and noisy. We find that in the presence of perception errors, most leading-eight strategies cease to be stable. Even if a leading-eight strategy evolves, cooperation rates may drop considerably when errors are common. Our research highlights the role of reliable information and synchronized reputations to maintain stable moral systems.","lang":"eng"}],"external_id":{"pmid":["30429320"],"isi":["000451351000063"]},"project":[{"call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425","name":"Quantitative Graph Games: Theory and Applications","grant_number":"279307"},{"_id":"2584A770-B435-11E9-9278-68D0E5697425","grant_number":"P 23499-N23","name":"Modern Graph Algorithmic Techniques in Formal Verification","call_identifier":"FWF"},{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","call_identifier":"FWF"},{"call_identifier":"FP7","grant_number":"291734","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"department":[{"_id":"KrCh"}],"title":"Indirect reciprocity with private, noisy, and incomplete information","oa_version":"Submitted Version","date_created":"2018-12-11T11:44:05Z","doi":"10.1073/pnas.1810565115","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pubmed/30429320","open_access":"1"}],"article_processing_charge":"No","language":[{"iso":"eng"}],"intvolume":"       115","publication_status":"published","pmid":1,"_id":"2","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"10293"}],"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/no-cooperation-without-open-communication/","relation":"press_release"}]},"isi":1,"date_published":"2018-11-27T00:00:00Z"},{"month":"11","arxiv":1,"type":"journal_article","abstract":[{"lang":"eng","text":"Solid-state qubit manipulation and read-out fidelities are reaching fault-tolerance, but quantum error correction requires millions of physical qubits and therefore a scalable quantum computer architecture. To solve signal-line bandwidth and fan-out problems, microwave sources required for qubit manipulation might be embedded close to the qubit chip, typically operating at temperatures below 4 K. Here, we perform the first low temperature measurements of a 130 nm BiCMOS based SiGe voltage controlled oscillator at cryogenic temperature. We determined the frequency and output power dependence on temperature and magnetic field up to 5 T and measured the temperature influence on its noise performance. The device maintains its full functionality from 300 K to 4 K. The carrier frequency at 4 K increases by 3% with respect to the carrier frequency at 300 K, and the output power at 4 K increases by 10 dB relative to the output power at 300 K. The frequency tuning range of approximately 20% remains unchanged between 300 K and 4 K. In an in-plane magnetic field of 5 T, the carrier frequency shifts by only 0.02% compared to the frequency at zero magnetic field."}],"external_id":{"arxiv":["1804.09522"],"isi":["000451735700054"]},"publication_identifier":{"issn":["0034-6748"]},"department":[{"_id":"GeKa"}],"title":"30 GHz-voltage controlled oscillator operating at 4 K","doi":"10.1063/1.5038258","oa_version":"Preprint","date_created":"2019-01-10T14:22:23Z","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1804.09522"}],"language":[{"iso":"eng"}],"intvolume":"        89","publication_status":"published","related_material":{"record":[{"status":"public","id":"10058","relation":"dissertation_contains"}]},"_id":"5816","isi":1,"date_published":"2018-11-01T00:00:00Z","quality_controlled":"1","oa":1,"day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":89,"issue":"11","publisher":"AIP Publishing","scopus_import":"1","status":"public","publication":"Review of Scientific Instruments","citation":{"ista":"Hollmann A, Jirovec D, Kucharski M, Kissinger D, Fischer G, Schreiber LR. 2018. 30 GHz-voltage controlled oscillator operating at 4 K. Review of Scientific Instruments. 89(11), 114701.","short":"A. Hollmann, D. Jirovec, M. Kucharski, D. Kissinger, G. Fischer, L.R. Schreiber, Review of Scientific Instruments 89 (2018).","chicago":"Hollmann, Arne, Daniel Jirovec, Maciej Kucharski, Dietmar Kissinger, Gunter Fischer, and Lars R. Schreiber. “30 GHz-Voltage Controlled Oscillator Operating at 4 K.” <i>Review of Scientific Instruments</i>. AIP Publishing, 2018. <a href=\"https://doi.org/10.1063/1.5038258\">https://doi.org/10.1063/1.5038258</a>.","mla":"Hollmann, Arne, et al. “30 GHz-Voltage Controlled Oscillator Operating at 4 K.” <i>Review of Scientific Instruments</i>, vol. 89, no. 11, 114701, AIP Publishing, 2018, doi:<a href=\"https://doi.org/10.1063/1.5038258\">10.1063/1.5038258</a>.","ieee":"A. Hollmann, D. Jirovec, M. Kucharski, D. Kissinger, G. Fischer, and L. R. Schreiber, “30 GHz-voltage controlled oscillator operating at 4 K,” <i>Review of Scientific Instruments</i>, vol. 89, no. 11. AIP Publishing, 2018.","ama":"Hollmann A, Jirovec D, Kucharski M, Kissinger D, Fischer G, Schreiber LR. 30 GHz-voltage controlled oscillator operating at 4 K. <i>Review of Scientific Instruments</i>. 2018;89(11). doi:<a href=\"https://doi.org/10.1063/1.5038258\">10.1063/1.5038258</a>","apa":"Hollmann, A., Jirovec, D., Kucharski, M., Kissinger, D., Fischer, G., &#38; Schreiber, L. R. (2018). 30 GHz-voltage controlled oscillator operating at 4 K. <i>Review of Scientific Instruments</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/1.5038258\">https://doi.org/10.1063/1.5038258</a>"},"article_number":"114701","author":[{"full_name":"Hollmann, Arne","first_name":"Arne","last_name":"Hollmann"},{"orcid":"0000-0002-7197-4801","id":"4C473F58-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel","last_name":"Jirovec","full_name":"Jirovec, Daniel"},{"full_name":"Kucharski, Maciej","first_name":"Maciej","last_name":"Kucharski"},{"full_name":"Kissinger, Dietmar","first_name":"Dietmar","last_name":"Kissinger"},{"full_name":"Fischer, Gunter","last_name":"Fischer","first_name":"Gunter"},{"full_name":"Schreiber, Lars R.","last_name":"Schreiber","first_name":"Lars R."}],"year":"2018","date_updated":"2026-04-29T22:30:40Z"},{"article_type":"original","quality_controlled":"1","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"day":"01","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","volume":223,"issue":"3","file":[{"checksum":"a55b3103476ecb5f4f983d8801807e8b","content_type":"application/pdf","file_size":5542926,"date_updated":"2020-07-14T12:47:20Z","access_level":"open_access","date_created":"2018-12-12T10:15:36Z","creator":"system","file_name":"IST-2018-1013-v1+1_2018_Kleindienst_Differential.pdf","relation":"main_file","file_id":"5157"}],"publisher":"Springer","ec_funded":1,"scopus_import":"1","has_accepted_license":"1","status":"public","publication":"Brain Structure and Function","ddc":["571"],"citation":{"ieee":"R. Luján <i>et al.</i>, “Differential association of GABAB receptors with their effector ion channels in Purkinje cells,” <i>Brain Structure and Function</i>, vol. 223, no. 3. Springer, pp. 1565–1587, 2018.","apa":"Luján, R., Aguado, C., Ciruela, F., Cózar, J., Kleindienst, D., De La Ossa, L., … Fukazawa, Y. (2018). Differential association of GABAB receptors with their effector ion channels in Purkinje cells. <i>Brain Structure and Function</i>. Springer. <a href=\"https://doi.org/10.1007/s00429-017-1568-y\">https://doi.org/10.1007/s00429-017-1568-y</a>","mla":"Luján, Rafael, et al. “Differential Association of GABAB Receptors with Their Effector Ion Channels in Purkinje Cells.” <i>Brain Structure and Function</i>, vol. 223, no. 3, Springer, 2018, pp. 1565–87, doi:<a href=\"https://doi.org/10.1007/s00429-017-1568-y\">10.1007/s00429-017-1568-y</a>.","ama":"Luján R, Aguado C, Ciruela F, et al. Differential association of GABAB receptors with their effector ion channels in Purkinje cells. <i>Brain Structure and Function</i>. 2018;223(3):1565-1587. doi:<a href=\"https://doi.org/10.1007/s00429-017-1568-y\">10.1007/s00429-017-1568-y</a>","short":"R. Luján, C. Aguado, F. Ciruela, J. Cózar, D. Kleindienst, L. De La Ossa, B. Bettler, K. Wickman, M. Watanabe, R. Shigemoto, Y. Fukazawa, Brain Structure and Function 223 (2018) 1565–1587.","ista":"Luján R, Aguado C, Ciruela F, Cózar J, Kleindienst D, De La Ossa L, Bettler B, Wickman K, Watanabe M, Shigemoto R, Fukazawa Y. 2018. Differential association of GABAB receptors with their effector ion channels in Purkinje cells. Brain Structure and Function. 223(3), 1565–1587.","chicago":"Luján, Rafael, Carolina Aguado, Francisco Ciruela, Javier Cózar, David Kleindienst, Luis De La Ossa, Bernhard Bettler, et al. “Differential Association of GABAB Receptors with Their Effector Ion Channels in Purkinje Cells.” <i>Brain Structure and Function</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s00429-017-1568-y\">https://doi.org/10.1007/s00429-017-1568-y</a>."},"page":"1565 - 1587","author":[{"full_name":"Luján, Rafael","last_name":"Luján","first_name":"Rafael"},{"full_name":"Aguado, Carolina","last_name":"Aguado","first_name":"Carolina"},{"full_name":"Ciruela, Francisco","first_name":"Francisco","last_name":"Ciruela"},{"first_name":"Javier","last_name":"Cózar","full_name":"Cózar, Javier"},{"id":"42E121A4-F248-11E8-B48F-1D18A9856A87","first_name":"David","last_name":"Kleindienst","full_name":"Kleindienst, David"},{"full_name":"De La Ossa, Luis","last_name":"De La Ossa","first_name":"Luis"},{"last_name":"Bettler","first_name":"Bernhard","full_name":"Bettler, Bernhard"},{"full_name":"Wickman, Kevin","last_name":"Wickman","first_name":"Kevin"},{"full_name":"Watanabe, Masahiko","first_name":"Masahiko","last_name":"Watanabe"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"last_name":"Fukazawa","first_name":"Yugo","full_name":"Fukazawa, Yugo"}],"year":"2018","date_updated":"2026-04-29T22:30:40Z","month":"04","type":"journal_article","file_date_updated":"2020-07-14T12:47:20Z","abstract":[{"lang":"eng","text":"Metabotropic GABAB receptors mediate slow inhibitory effects presynaptically and postsynaptically through the modulation of different effector signalling pathways. Here, we analysed the distribution of GABAB receptors using highly sensitive SDS-digested freeze-fracture replica labelling in mouse cerebellar Purkinje cells. Immunoreactivity for GABAB1 was observed on presynaptic and, more abundantly, on postsynaptic compartments, showing both scattered and clustered distribution patterns. Quantitative analysis of immunoparticles revealed a somato-dendritic gradient, with the density of immunoparticles increasing 26-fold from somata to dendritic spines. To understand the spatial relationship of GABAB receptors with two key effector ion channels, the G protein-gated inwardly rectifying K+ (GIRK/Kir3) channel and the voltage-dependent Ca2+ channel, biochemical and immunohistochemical approaches were performed. Co-immunoprecipitation analysis demonstrated that GABAB receptors co-assembled with GIRK and CaV2.1 channels in the cerebellum. Using double-labelling immunoelectron microscopic techniques, co-clustering between GABAB1 and GIRK2 was detected in dendritic spines, whereas they were mainly segregated in the dendritic shafts. In contrast, co-clustering of GABAB1 and CaV2.1 was detected in dendritic shafts but not spines. Presynaptically, although no significant co-clustering of GABAB1 and GIRK2 or CaV2.1 channels was detected, inter-cluster distance for GABAB1 and GIRK2 was significantly smaller in the active zone than in the dendritic shafts, and that for GABAB1 and CaV2.1 was significantly smaller in the active zone than in the dendritic shafts and spines. Thus, GABAB receptors are associated with GIRK and CaV2.1 channels in different subcellular compartments. These data provide a better framework for understanding the different roles played by GABAB receptors and their effector ion channels in the cerebellar network."}],"external_id":{"isi":["000428419500030"]},"project":[{"name":"Human Brain Project Specific Grant Agreement 1","grant_number":"720270","_id":"25CBA828-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"}],"pubrep_id":"1013","department":[{"_id":"RySh"}],"title":"Differential association of GABAB receptors with their effector ion channels in Purkinje cells","oa_version":"Published Version","doi":"10.1007/s00429-017-1568-y","date_created":"2018-12-11T11:47:29Z","article_processing_charge":"No","language":[{"iso":"eng"}],"intvolume":"       223","publication_status":"published","publist_id":"7192","_id":"612","related_material":{"record":[{"relation":"dissertation_contains","id":"9562","status":"public"}]},"isi":1,"date_published":"2018-04-01T00:00:00Z"}]