[{"date_published":"2018-07-09T00:00:00Z","title":"Efficient algorithms for asymptotic bounds on termination time in VASS","scopus_import":"1","main_file_link":[{"url":"https://arxiv.org/abs/1804.10985","open_access":"1"}],"year":"2018","author":[{"full_name":"Brázdil, Tomáš","last_name":"Brázdil","first_name":"Tomáš"},{"last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kučera","full_name":"Kučera, Antonín","first_name":"Antonín"},{"first_name":"Petr","id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","last_name":"Novotny","full_name":"Novotny, Petr"},{"last_name":"Velan","full_name":"Velan, Dominik","first_name":"Dominik"},{"last_name":"Zuleger","full_name":"Zuleger, Florian","first_name":"Florian"}],"publisher":"IEEE","date_created":"2018-12-11T11:44:51Z","isi":1,"quality_controlled":"1","ec_funded":1,"publication_identifier":{"isbn":["978-1-4503-5583-4"]},"arxiv":1,"alternative_title":["ACM/IEEE Symposium on Logic in Computer Science"],"status":"public","conference":{"name":"LICS: Logic in Computer Science","start_date":"2018-07-09","location":"Oxford, United Kingdom","end_date":"2018-07-12"},"department":[{"_id":"KrCh"}],"external_id":{"isi":["000545262800020"],"arxiv":["1804.10985"]},"publication_status":"published","volume":"F138033","day":"09","month":"07","language":[{"iso":"eng"}],"publist_id":"7780","type":"conference","project":[{"name":"Efficient Algorithms for Computer Aided Verification","grant_number":"ICT15-003","_id":"25892FC0-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FP7","grant_number":"279307","name":"Quantitative Graph Games: Theory and Applications","_id":"2581B60A-B435-11E9-9278-68D0E5697425"},{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Rigorous Systems Engineering","grant_number":"S 11407_N23"}],"doi":"10.1145/3209108.3209191","_id":"143","abstract":[{"lang":"eng","text":"Vector Addition Systems with States (VASS) provide a well-known and fundamental model for the analysis of concurrent processes, parameterized systems, and are also used as abstract models of programs in resource bound analysis. In this paper we study the problem of obtaining asymptotic bounds on the termination time of a given VASS. In particular, we focus on the practically important case of obtaining polynomial bounds on termination time. Our main contributions are as follows: First, we present a polynomial-time algorithm for deciding whether a given VASS has a linear asymptotic complexity. We also show that if the complexity of a VASS is not linear, it is at least quadratic. Second, we classify VASS according to quantitative properties of their cycles. We show that certain singularities in these properties are the key reason for non-polynomial asymptotic complexity of VASS. In absence of singularities, we show that the asymptotic complexity is always polynomial and of the form Θ(nk), for some integer k d, where d is the dimension of the VASS. We present a polynomial-time algorithm computing the optimal k. For general VASS, the same algorithm, which is based on a complete technique for the construction of ranking functions in VASS, produces a valid lower bound, i.e., a k such that the termination complexity is (nk). Our results are based on new insights into the geometry of VASS dynamics, which hold the potential for further applicability to VASS analysis."}],"article_processing_charge":"No","oa_version":"Preprint","date_updated":"2025-06-04T08:04:55Z","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"185 - 194","citation":{"ieee":"T. Brázdil, K. Chatterjee, A. Kučera, P. Novotný, D. Velan, and F. Zuleger, “Efficient algorithms for asymptotic bounds on termination time in VASS,” presented at the LICS: Logic in Computer Science, Oxford, United Kingdom, 2018, vol. F138033, pp. 185–194.","short":"T. Brázdil, K. Chatterjee, A. Kučera, P. Novotný, D. Velan, F. Zuleger, in:, IEEE, 2018, pp. 185–194.","apa":"Brázdil, T., Chatterjee, K., Kučera, A., Novotný, P., Velan, D., &#38; Zuleger, F. (2018). Efficient algorithms for asymptotic bounds on termination time in VASS (Vol. F138033, pp. 185–194). Presented at the LICS: Logic in Computer Science, Oxford, United Kingdom: IEEE. <a href=\"https://doi.org/10.1145/3209108.3209191\">https://doi.org/10.1145/3209108.3209191</a>","ista":"Brázdil T, Chatterjee K, Kučera A, Novotný P, Velan D, Zuleger F. 2018. Efficient algorithms for asymptotic bounds on termination time in VASS. LICS: Logic in Computer Science, ACM/IEEE Symposium on Logic in Computer Science, vol. F138033, 185–194.","mla":"Brázdil, Tomáš, et al. <i>Efficient Algorithms for Asymptotic Bounds on Termination Time in VASS</i>. Vol. F138033, IEEE, 2018, pp. 185–94, doi:<a href=\"https://doi.org/10.1145/3209108.3209191\">10.1145/3209108.3209191</a>.","chicago":"Brázdil, Tomáš, Krishnendu Chatterjee, Antonín Kučera, Petr Novotný, Dominik Velan, and Florian Zuleger. “Efficient Algorithms for Asymptotic Bounds on Termination Time in VASS,” F138033:185–94. IEEE, 2018. <a href=\"https://doi.org/10.1145/3209108.3209191\">https://doi.org/10.1145/3209108.3209191</a>.","ama":"Brázdil T, Chatterjee K, Kučera A, Novotný P, Velan D, Zuleger F. Efficient algorithms for asymptotic bounds on termination time in VASS. In: Vol F138033. IEEE; 2018:185-194. doi:<a href=\"https://doi.org/10.1145/3209108.3209191\">10.1145/3209108.3209191</a>"}},{"date_updated":"2024-10-14T12:31:46Z","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"citation":{"ista":"Praetorius FM. 2018. Genetically encoding the spatial arrangement of DNA and proteins in self-assembling nanostructures. Technische Universität München.","apa":"Praetorius, F. M. (2018). <i>Genetically encoding the spatial arrangement of DNA and proteins in self-assembling nanostructures</i>. Technische Universität München.","short":"F.M. Praetorius, Genetically Encoding the Spatial Arrangement of DNA and Proteins in Self-Assembling Nanostructures, Technische Universität München, 2018.","ieee":"F. M. Praetorius, “Genetically encoding the spatial arrangement of DNA and proteins in self-assembling nanostructures,” Technische Universität München, 2018.","ama":"Praetorius FM. Genetically encoding the spatial arrangement of DNA and proteins in self-assembling nanostructures. 2018.","chicago":"Praetorius, Florian M. “Genetically Encoding the Spatial Arrangement of DNA and Proteins in Self-Assembling Nanostructures.” Technische Universität München, 2018.","mla":"Praetorius, Florian M. <i>Genetically Encoding the Spatial Arrangement of DNA and Proteins in Self-Assembling Nanostructures</i>. Technische Universität München, 2018."},"publication_status":"published","type":"dissertation","_id":"14306","abstract":[{"lang":"eng","text":"Function and activity of biomolecules often depend on their spatial arrangement. The method introduced here allows genetically encoding the spatial arrangement of proteins and DNA. The approach relies on staple proteins that fold double-stranded DNA into user-defined shapes. This thesis describes the development of staple proteins based on the DNA recognition of TAL effectors and presents experimentally derived rules for designing a variety of self-assembling nanoscale shapes featuring structural motifs such as curvature, vertices, corners, and multilayer helix packing. "}],"article_processing_charge":"No","oa_version":"Published Version","supervisor":[{"first_name":"Hendrik","last_name":"Dietz","full_name":"Dietz, Hendrik"}],"status":"public","year":"2018","day":"16","author":[{"id":"dfec9381-4341-11ee-8fd8-faa02bba7d62","first_name":"Florian M","full_name":"Praetorius, Florian M","last_name":"Praetorius"}],"publisher":"Technische Universität München","degree_awarded":"PhD","date_created":"2023-09-06T13:11:22Z","language":[{"iso":"eng"}],"month":"01","date_published":"2018-01-16T00:00:00Z","title":"Genetically encoding the spatial arrangement of DNA and proteins in self-assembling nanostructures","main_file_link":[{"url":"https://mediatum.ub.tum.de/1398662","open_access":"1"}]},{"abstract":[{"lang":"eng","text":"A common assumption in causal modeling posits that the data is generated by a\r\nset of independent mechanisms, and algorithms should aim to recover this\r\nstructure. Standard unsupervised learning, however, is often concerned with\r\ntraining a single model to capture the overall distribution or aspects thereof.\r\nInspired by clustering approaches, we consider mixtures of implicit generative\r\nmodels that ``disentangle'' the independent generative mechanisms underlying\r\nthe data. Relying on an additional set of discriminators, we propose a\r\ncompetitive training procedure in which the models only need to capture the\r\nportion of the data distribution from which they can produce realistic samples.\r\nAs a by-product, each model is simpler and faster to train. We empirically show\r\nthat our approach splits the training distribution in a sensible way and\r\nincreases the quality of the generated samples."}],"_id":"14327","arxiv":1,"doi":"10.48550/arXiv.1804.11130","oa_version":"Preprint","article_processing_charge":"No","type":"preprint","status":"public","article_number":"1804.11130","publication":"arXiv","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","date_updated":"2024-10-14T12:31:09Z","publication_status":"submitted","external_id":{"arxiv":["1804.11130"]},"department":[{"_id":"FrLo"}],"citation":{"ieee":"F. Locatello, D. Vincent, I. Tolstikhin, G. Rätsch, S. Gelly, and B. Schölkopf, “Competitive training of mixtures of independent deep generative models,” <i>arXiv</i>. .","ista":"Locatello F, Vincent D, Tolstikhin I, Rätsch G, Gelly S, Schölkopf B. Competitive training of mixtures of independent deep generative models. arXiv, 1804.11130.","apa":"Locatello, F., Vincent, D., Tolstikhin, I., Rätsch, G., Gelly, S., &#38; Schölkopf, B. (n.d.). Competitive training of mixtures of independent deep generative models. <i>arXiv</i>. <a href=\"https://doi.org/10.48550/arXiv.1804.11130\">https://doi.org/10.48550/arXiv.1804.11130</a>","short":"F. Locatello, D. Vincent, I. Tolstikhin, G. Rätsch, S. Gelly, B. Schölkopf, ArXiv (n.d.).","chicago":"Locatello, Francesco, Damien Vincent, Ilya Tolstikhin, Gunnar Rätsch, Sylvain Gelly, and Bernhard Schölkopf. “Competitive Training of Mixtures of Independent Deep Generative Models.” <i>ArXiv</i>, n.d. <a href=\"https://doi.org/10.48550/arXiv.1804.11130\">https://doi.org/10.48550/arXiv.1804.11130</a>.","mla":"Locatello, Francesco, et al. “Competitive Training of Mixtures of Independent Deep Generative Models.” <i>ArXiv</i>, 1804.11130, doi:<a href=\"https://doi.org/10.48550/arXiv.1804.11130\">10.48550/arXiv.1804.11130</a>.","ama":"Locatello F, Vincent D, Tolstikhin I, Rätsch G, Gelly S, Schölkopf B. Competitive training of mixtures of independent deep generative models. <i>arXiv</i>. doi:<a href=\"https://doi.org/10.48550/arXiv.1804.11130\">10.48550/arXiv.1804.11130</a>"},"date_published":"2018-04-30T00:00:00Z","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1804.11130","open_access":"1"}],"title":"Competitive training of mixtures of independent deep generative models","author":[{"id":"26cfd52f-2483-11ee-8040-88983bcc06d4","first_name":"Francesco","last_name":"Locatello","full_name":"Locatello, Francesco","orcid":"0000-0002-4850-0683"},{"first_name":"Damien","last_name":"Vincent","full_name":"Vincent, Damien"},{"first_name":"Ilya","full_name":"Tolstikhin, Ilya","last_name":"Tolstikhin"},{"first_name":"Gunnar","full_name":"Rätsch, Gunnar","last_name":"Rätsch"},{"first_name":"Sylvain","full_name":"Gelly, Sylvain","last_name":"Gelly"},{"last_name":"Schölkopf","full_name":"Schölkopf, Bernhard","first_name":"Bernhard"}],"year":"2018","day":"30","month":"04","language":[{"iso":"eng"}],"date_created":"2023-09-13T12:20:49Z"},{"conference":{"name":"LICS: Logic in Computer Science","start_date":"2018-07-09","location":"Oxford, UK","end_date":"2018-07-12"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-08T11:49:13Z","publication_status":"published","external_id":{"isi":["000545262800041"]},"page":"394 - 403","department":[{"_id":"ToHe"}],"citation":{"ama":"Ferrere T, Henzinger TA, Saraç E. A theory of register monitors. In: Vol Part F138033. IEEE; 2018:394-403. doi:<a href=\"https://doi.org/10.1145/3209108.3209194\">10.1145/3209108.3209194</a>","mla":"Ferrere, Thomas, et al. <i>A Theory of Register Monitors</i>. Vol. Part F138033, IEEE, 2018, pp. 394–403, doi:<a href=\"https://doi.org/10.1145/3209108.3209194\">10.1145/3209108.3209194</a>.","chicago":"Ferrere, Thomas, Thomas A Henzinger, and Ege Saraç. “A Theory of Register Monitors,” Part F138033:394–403. IEEE, 2018. <a href=\"https://doi.org/10.1145/3209108.3209194\">https://doi.org/10.1145/3209108.3209194</a>.","short":"T. Ferrere, T.A. Henzinger, E. Saraç, in:, IEEE, 2018, pp. 394–403.","ista":"Ferrere T, Henzinger TA, Saraç E. 2018. A theory of register monitors. LICS: Logic in Computer Science, ACM/IEEE Symposium on Logic in Computer Science, vol. Part F138033, 394–403.","apa":"Ferrere, T., Henzinger, T. A., &#38; Saraç, E. (2018). A theory of register monitors (Vol. Part F138033, pp. 394–403). Presented at the LICS: Logic in Computer Science, Oxford, UK: IEEE. <a href=\"https://doi.org/10.1145/3209108.3209194\">https://doi.org/10.1145/3209108.3209194</a>","ieee":"T. Ferrere, T. A. Henzinger, and E. Saraç, “A theory of register monitors,” presented at the LICS: Logic in Computer Science, Oxford, UK, 2018, vol. Part F138033, pp. 394–403."},"_id":"144","doi":"10.1145/3209108.3209194","abstract":[{"lang":"eng","text":"The task of a monitor is to watch, at run-time, the execution of a reactive system, and signal the occurrence of a safety violation in the observed sequence of events. While finite-state monitors have been studied extensively, in practice, monitoring software also makes use of unbounded memory. We define a model of automata equipped with integer-valued registers which can execute only a bounded number of instructions between consecutive events, and thus can form the theoretical basis for the study of infinite-state monitors. We classify these register monitors according to the number k of available registers, and the type of register instructions. In stark contrast to the theory of computability for register machines, we prove that for every k 1, monitors with k + 1 counters (with instruction set 〈+1, =〉) are strictly more expressive than monitors with k counters. We also show that adder monitors (with instruction set 〈1, +, =〉) are strictly more expressive than counter monitors, but are complete for monitoring all computable safety -languages for k = 6. Real-time monitors are further required to signal the occurrence of a safety violation as soon as it occurs. The expressiveness hierarchy for counter monitors carries over to real-time monitors. We then show that 2 adders cannot simulate 3 counters in real-time. Finally, we show that real-time adder monitors with inequalities are as expressive as real-time Turing machines."}],"oa_version":"None","article_processing_charge":"No","publist_id":"7779","type":"conference","status":"public","alternative_title":["ACM/IEEE Symposium on Logic in Computer Science"],"author":[{"last_name":"Ferrere","orcid":"0000-0001-5199-3143","full_name":"Ferrere, Thomas","id":"40960E6E-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas"},{"last_name":"Henzinger","orcid":"0000−0002−2985−7724","full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A"},{"first_name":"Ege","full_name":"Saraç, Ege","last_name":"Saraç"}],"publisher":"IEEE","volume":"Part F138033","year":"2018","day":"09","quality_controlled":"1","isi":1,"language":[{"iso":"eng"}],"month":"07","date_created":"2018-12-11T11:44:52Z","date_published":"2018-07-09T00:00:00Z","scopus_import":"1","title":"A theory of register monitors"},{"publication":"The EMBO Journal","article_processing_charge":"No","oa_version":"Published Version","_id":"145","abstract":[{"text":"Aged proteins can become hazardous to cellular function, by accumulating molecular damage. This implies that cells should preferentially rely on newly produced ones. We tested this hypothesis in cultured hippocampal neurons, focusing on synaptic transmission. We found that newly synthesized vesicle proteins were incorporated in the actively recycling pool of vesicles responsible for all neurotransmitter release during physiological activity. We observed this for the calcium sensor Synaptotagmin 1, for the neurotransmitter transporter VGAT, and for the fusion protein VAMP2 (Synaptobrevin 2). Metabolic labeling of proteins and visualization by secondary ion mass spectrometry enabled us to query the entire protein makeup of the actively recycling vesicles, which we found to be younger than that of non-recycling vesicles. The young vesicle proteins remained in use for up to ~ 24 h, during which they participated in recycling a few hundred times. They were afterward reluctant to release and were degraded after an additional ~ 24–48 h. We suggest that the recycling pool of synaptic vesicles relies on newly synthesized proteins, while the inactive reserve pool contains older proteins.","lang":"eng"}],"doi":"10.15252/embj.201798044","type":"journal_article","publist_id":"7778","citation":{"short":"S.M. Truckenbrodt, A. Viplav, S. Jähne, A. Vogts, A. Denker, H. Wildhagen, E. Fornasiero, S. Rizzoli, The EMBO Journal 37 (2018).","ista":"Truckenbrodt SM, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero E, Rizzoli S. 2018. Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. The EMBO Journal. 37(15), e98044.","apa":"Truckenbrodt, S. M., Viplav, A., Jähne, S., Vogts, A., Denker, A., Wildhagen, H., … Rizzoli, S. (2018). Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. <i>The EMBO Journal</i>. Wiley. <a href=\"https://doi.org/10.15252/embj.201798044\">https://doi.org/10.15252/embj.201798044</a>","ieee":"S. M. Truckenbrodt <i>et al.</i>, “Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission,” <i>The EMBO Journal</i>, vol. 37, no. 15. Wiley, 2018.","ama":"Truckenbrodt SM, Viplav A, Jähne S, et al. Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. <i>The EMBO Journal</i>. 2018;37(15). doi:<a href=\"https://doi.org/10.15252/embj.201798044\">10.15252/embj.201798044</a>","mla":"Truckenbrodt, Sven M., et al. “Newly Produced Synaptic Vesicle Proteins Are Preferentially Used in Synaptic Transmission.” <i>The EMBO Journal</i>, vol. 37, no. 15, e98044, Wiley, 2018, doi:<a href=\"https://doi.org/10.15252/embj.201798044\">10.15252/embj.201798044</a>.","chicago":"Truckenbrodt, Sven M, Abhiyan Viplav, Sebsatian Jähne, Angela Vogts, Annette Denker, Hanna Wildhagen, Eugenio Fornasiero, and Silvio Rizzoli. “Newly Produced Synaptic Vesicle Proteins Are Preferentially Used in Synaptic Transmission.” <i>The EMBO Journal</i>. Wiley, 2018. <a href=\"https://doi.org/10.15252/embj.201798044\">https://doi.org/10.15252/embj.201798044</a>."},"acknowledgement":"We thank Reinhard Jahn for providing a plasmid for YFP-SNAP25. We thank Erwin Neher for help with the development of the mathematical model of the synaptic vesicle life cycle. We thank Martin Meschkat, Andreas Höbartner, Annedore Punge, and Peer Hoopmann for help with the experiments. We thank Burkhard Rammner for providing the illustrations of synaptic vesicle and protein dynamics. We thank Manuel Maidorn, Martin Helm, and Katharina N. Richter for critically reading the manuscript. S.T. was supported by an Excellence Stipend of the Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences (GGNB). E.F.F. is a recipient of long-term fellowships from the European Molecular Biology Organization (ALTF_797-2012) and from the Human Frontier Science Program (HFSP_LT000830/2013). The work was supported by grants to S.O.R. from the European Research Council (ERC-2013-CoG NeuroMolAnatomy) and from the Deutsche Forschungsgemeinschaft (Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, SFB1190/P09, SFB889/A05, and SFB1286/A03, and DFG RI 1967 7/1). The nanoSIMS instrument was funded by the German Federal Ministry of Education and Research (03F0626A).","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2024-10-09T20:58:32Z","file_date_updated":"2020-07-14T12:44:56Z","language":[{"iso":"eng"}],"month":"08","day":"01","volume":37,"status":"public","article_number":"e98044","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"file":[{"creator":"dernst","checksum":"a540feb6c9af6aefc78de531461a8835","file_size":2846470,"relation":"main_file","content_type":"application/pdf","file_name":"2018_EMBO_Truckenbrodt.pdf","date_created":"2018-12-17T14:17:29Z","file_id":"5710","access_level":"open_access","date_updated":"2020-07-14T12:44:56Z"}],"publication_status":"published","external_id":{"isi":["000440416900005"],"pmid":["29950309"]},"corr_author":"1","has_accepted_license":"1","department":[{"_id":"JoDa"}],"scopus_import":"1","article_type":"original","issue":"15","title":"Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission","date_published":"2018-08-01T00:00:00Z","publication_identifier":{"issn":["0261-4189"]},"pmid":1,"date_created":"2018-12-11T11:44:52Z","isi":1,"quality_controlled":"1","ddc":["570"],"publisher":"Wiley","author":[{"full_name":"Truckenbrodt, Sven M","last_name":"Truckenbrodt","first_name":"Sven M","id":"45812BD4-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Abhiyan","last_name":"Viplav","full_name":"Viplav, Abhiyan"},{"first_name":"Sebsatian","full_name":"Jähne, Sebsatian","last_name":"Jähne"},{"last_name":"Vogts","full_name":"Vogts, Angela","first_name":"Angela"},{"last_name":"Denker","full_name":"Denker, Annette","first_name":"Annette"},{"full_name":"Wildhagen, Hanna","last_name":"Wildhagen","first_name":"Hanna"},{"last_name":"Fornasiero","full_name":"Fornasiero, Eugenio","first_name":"Eugenio"},{"first_name":"Silvio","last_name":"Rizzoli","full_name":"Rizzoli, Silvio"}],"year":"2018","intvolume":"        37"},{"file":[{"file_id":"7043","access_level":"open_access","date_updated":"2020-07-14T12:44:56Z","content_type":"application/pdf","file_name":"2018_NaturePlants_Shi.pdf","date_created":"2019-11-18T16:24:07Z","relation":"main_file","creator":"dernst","checksum":"da33101c76ee1b2dc5ab28fd2ccba9d0","file_size":226829}],"status":"public","department":[{"_id":"JiFr"}],"has_accepted_license":"1","external_id":{"isi":["000443861300016"],"pmid":["30061750"]},"publication_status":"published","related_material":{"link":[{"url":"https://ist.ac.at/en/news/new-process-in-root-development-discovered/","relation":"press_release","description":"News on IST Homepage"}]},"date_published":"2018-07-30T00:00:00Z","title":"The dynamics of root cap sloughing in Arabidopsis is regulated by peptide signalling","issue":"8","scopus_import":"1","article_type":"original","intvolume":"         4","year":"2018","author":[{"first_name":"Chun Lin","full_name":"Shi, Chun Lin","last_name":"Shi"},{"id":"49E91952-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel","full_name":"Von Wangenheim, Daniel","last_name":"Von Wangenheim","orcid":"0000-0002-6862-1247"},{"first_name":"Ullrich","last_name":"Herrmann","full_name":"Herrmann, Ullrich"},{"last_name":"Wildhagen","full_name":"Wildhagen, Mari","first_name":"Mari"},{"last_name":"Kulik","full_name":"Kulik, Ivan","first_name":"Ivan","id":"F0AB3FCE-02D1-11E9-BD0E-99399A5D3DEB"},{"last_name":"Kopf","full_name":"Kopf, Andreas","first_name":"Andreas"},{"last_name":"Ishida","full_name":"Ishida, Takashi","first_name":"Takashi"},{"first_name":"Vilde","full_name":"Olsson, Vilde","last_name":"Olsson"},{"last_name":"Anker","full_name":"Anker, Mari Kristine","first_name":"Mari Kristine"},{"last_name":"Albert","full_name":"Albert, Markus","first_name":"Markus"},{"first_name":"Melinka A","last_name":"Butenko","full_name":"Butenko, Melinka A"},{"full_name":"Felix, Georg","last_name":"Felix","first_name":"Georg"},{"first_name":"Shinichiro","full_name":"Sawa, Shinichiro","last_name":"Sawa"},{"last_name":"Claassen","full_name":"Claassen, Manfred","first_name":"Manfred"},{"last_name":"Friml","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Aalen","full_name":"Aalen, Reidunn B","first_name":"Reidunn B"}],"publisher":"Nature Publishing Group","ddc":["580"],"isi":1,"date_created":"2018-12-11T11:44:52Z","quality_controlled":"1","pmid":1,"publist_id":"7777","type":"journal_article","_id":"146","doi":"10.1038/s41477-018-0212-z","abstract":[{"text":"The root cap protects the stem cell niche of angiosperm roots from damage. In Arabidopsis, lateral root cap (LRC) cells covering the meristematic zone are regularly lost through programmed cell death, while the outermost layer of the root cap covering the tip is repeatedly sloughed. Efficient coordination with stem cells producing new layers is needed to maintain a constant size of the cap. We present a signalling pair, the peptide IDA-LIKE1 (IDL1) and its receptor HAESA-LIKE2 (HSL2), mediating such communication. Live imaging over several days characterized this process from initial fractures in LRC cell files to full separation of a layer. Enhanced expression of IDL1 in the separating root cap layers resulted in increased frequency of sloughing, balanced with generation of new layers in a HSL2-dependent manner. Transcriptome analyses linked IDL1-HSL2 signalling to the transcription factors BEARSKIN1/2 and genes associated with programmed cell death. Mutations in either IDL1 or HSL2 slowed down cell division, maturation and separation. Thus, IDL1-HSL2 signalling potentiates dynamic regulation of the homeostatic balance between stem cell division and sloughing activity.","lang":"eng"}],"article_processing_charge":"No","oa_version":"Submitted Version","publication":"Nature Plants","date_updated":"2023-09-19T10:08:45Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1,"page":"596 - 604","citation":{"short":"C.L. Shi, D. von Wangenheim, U. Herrmann, M. Wildhagen, I. Kulik, A. Kopf, T. Ishida, V. Olsson, M.K. Anker, M. Albert, M.A. Butenko, G. Felix, S. Sawa, M. Claassen, J. Friml, R.B. Aalen, Nature Plants 4 (2018) 596–604.","apa":"Shi, C. L., von Wangenheim, D., Herrmann, U., Wildhagen, M., Kulik, I., Kopf, A., … Aalen, R. B. (2018). The dynamics of root cap sloughing in Arabidopsis is regulated by peptide signalling. <i>Nature Plants</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41477-018-0212-z\">https://doi.org/10.1038/s41477-018-0212-z</a>","ista":"Shi CL, von Wangenheim D, Herrmann U, Wildhagen M, Kulik I, Kopf A, Ishida T, Olsson V, Anker MK, Albert M, Butenko MA, Felix G, Sawa S, Claassen M, Friml J, Aalen RB. 2018. The dynamics of root cap sloughing in Arabidopsis is regulated by peptide signalling. Nature Plants. 4(8), 596–604.","ieee":"C. L. Shi <i>et al.</i>, “The dynamics of root cap sloughing in Arabidopsis is regulated by peptide signalling,” <i>Nature Plants</i>, vol. 4, no. 8. Nature Publishing Group, pp. 596–604, 2018.","ama":"Shi CL, von Wangenheim D, Herrmann U, et al. The dynamics of root cap sloughing in Arabidopsis is regulated by peptide signalling. <i>Nature Plants</i>. 2018;4(8):596-604. doi:<a href=\"https://doi.org/10.1038/s41477-018-0212-z\">10.1038/s41477-018-0212-z</a>","mla":"Shi, Chun Lin, et al. “The Dynamics of Root Cap Sloughing in Arabidopsis Is Regulated by Peptide Signalling.” <i>Nature Plants</i>, vol. 4, no. 8, Nature Publishing Group, 2018, pp. 596–604, doi:<a href=\"https://doi.org/10.1038/s41477-018-0212-z\">10.1038/s41477-018-0212-z</a>.","chicago":"Shi, Chun Lin, Daniel von Wangenheim, Ullrich Herrmann, Mari Wildhagen, Ivan Kulik, Andreas Kopf, Takashi Ishida, et al. “The Dynamics of Root Cap Sloughing in Arabidopsis Is Regulated by Peptide Signalling.” <i>Nature Plants</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41477-018-0212-z\">https://doi.org/10.1038/s41477-018-0212-z</a>."},"file_date_updated":"2020-07-14T12:44:56Z","volume":4,"day":"30","month":"07","language":[{"iso":"eng"}]},{"acknowledgement":"We thank Gerd Jürgens, Sandra Richter, and Sheng Yang He for providing antibodies; Maciek Adamowski, Fernando Aniento, Sebastian Bednarek, Nico Callewaert, Matyás Fendrych, Elena Feraru, and Mugurel I. Feraru for helpful suggestions; Siamsa Doyle for critical reading of the manuscript and helpful comments and suggestions; and Stephanie Smith and Martine De Cock for help in editing and language corrections. We acknowledge the core facility Cellular Imaging of CEITEC supported by the Czech-BioImaging large RI project (LM2015062 funded by MEYS CR) for their support with obtaining scientific data presented in this article. Plant Sciences Core Facility of CEITEC Masaryk University is gratefully acknowledged for obtaining part of the scientific data presented in this article. We acknowledge support from the Fondation pour la Recherche Médicale and from the Institut National du Cancer (J.C.). The research leading to these results was funded by the European Research Council under the European Union's 7th Framework Program (FP7/2007-2013)/ERC grant agreement numbers 282300 and 742985 and the Czech Science Foundation GAČR (GA18-26981S; J.F.); Ministry of Education, Youth, and Sports/MEYS of the Czech Republic under the Project CEITEC 2020 (LQ1601; T.N.); the China Science Council for a predoctoral fellowship (Q.L.); a joint research project within the framework of cooperation between the Research Foundation-Flanders and the Bulgarian Academy of Sciences (VS.025.13N; K.M. and E.R.); Vetenskapsrådet and Vinnova (Verket för Innovationssystem; S.R.), Knut och Alice Wallenbergs Stiftelse via “Shapesystem” Grant 2012.0050 (S.R.), Kempe stiftelserna (P.G.), Tryggers CTS410 (P.G.).","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-06-18T17:36:26Z","page":"2553 - 2572","citation":{"apa":"Kania, U., Nodzyński, T., Lu, Q., Hicks, G. R., Nerinckx, W., Mishev, K., … Friml, J. (2018). The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with sub cellular trafficking in eukaryotes. <i>The Plant Cell</i>. Oxford University Press. <a href=\"https://doi.org/10.1105/tpc.18.00127\">https://doi.org/10.1105/tpc.18.00127</a>","ista":"Kania U, Nodzyński T, Lu Q, Hicks GR, Nerinckx W, Mishev K, Peurois F, Cherfils J, De RRM, Grones P, Robert S, Russinova E, Friml J. 2018. The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with sub cellular trafficking in eukaryotes. The Plant Cell. 30(10), 2553–2572.","short":"U. Kania, T. Nodzyński, Q. Lu, G.R. Hicks, W. Nerinckx, K. Mishev, F. Peurois, J. Cherfils, R.R.M. De, P. Grones, S. Robert, E. Russinova, J. Friml, The Plant Cell 30 (2018) 2553–2572.","ieee":"U. Kania <i>et al.</i>, “The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with sub cellular trafficking in eukaryotes,” <i>The Plant Cell</i>, vol. 30, no. 10. Oxford University Press, pp. 2553–2572, 2018.","ama":"Kania U, Nodzyński T, Lu Q, et al. The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with sub cellular trafficking in eukaryotes. <i>The Plant Cell</i>. 2018;30(10):2553-2572. doi:<a href=\"https://doi.org/10.1105/tpc.18.00127\">10.1105/tpc.18.00127</a>","chicago":"Kania, Urszula, Tomasz Nodzyński, Qing Lu, Glenn R Hicks, Wim Nerinckx, Kiril Mishev, Francois Peurois, et al. “The Inhibitor Endosidin 4 Targets SEC7 Domain-Type ARF GTPase Exchange Factors and Interferes with Sub Cellular Trafficking in Eukaryotes.” <i>The Plant Cell</i>. Oxford University Press, 2018. <a href=\"https://doi.org/10.1105/tpc.18.00127\">https://doi.org/10.1105/tpc.18.00127</a>.","mla":"Kania, Urszula, et al. “The Inhibitor Endosidin 4 Targets SEC7 Domain-Type ARF GTPase Exchange Factors and Interferes with Sub Cellular Trafficking in Eukaryotes.” <i>The Plant Cell</i>, vol. 30, no. 10, Oxford University Press, 2018, pp. 2553–72, doi:<a href=\"https://doi.org/10.1105/tpc.18.00127\">10.1105/tpc.18.00127</a>."},"_id":"147","abstract":[{"text":"The trafficking of subcellular cargos in eukaryotic cells crucially depends on vesicle budding, a process mediated by ARF-GEFs (ADP-ribosylation factor guanine nucleotide exchange factors). In plants, ARF-GEFs play essential roles in endocytosis, vacuolar trafficking, recycling, secretion, and polar trafficking. Moreover, they are important for plant development, mainly through controlling the polar subcellular localization of PIN-FORMED (PIN) transporters of the plant hormone auxin. Here, using a chemical genetics screen in Arabidopsis thaliana, we identified Endosidin 4 (ES4), an inhibitor of eukaryotic ARF-GEFs. ES4 acts similarly to and synergistically with the established ARF-GEF inhibitor Brefeldin A and has broad effects on intracellular trafficking, including endocytosis, exocytosis, and vacuolar targeting. Additionally, Arabidopsis and yeast (Sacharomyces cerevisiae) mutants defective in ARF-GEF show altered sensitivity to ES4. ES4 interferes with the activation-based membrane association of the ARF1 GTPases, but not of their mutant variants that are activated independently of ARF-GEF activity. Biochemical approaches and docking simulations confirmed that ES4 specifically targets the SEC7 domain-containing ARF-GEFs. These observations collectively identify ES4 as a chemical tool enabling the study of ARF-GEF-mediated processes, including ARF-GEF-mediated plant development.","lang":"eng"}],"doi":"10.1105/tpc.18.00127","article_processing_charge":"No","oa_version":"Published Version","publist_id":"7776","type":"journal_article","project":[{"_id":"25716A02-B435-11E9-9278-68D0E5697425","grant_number":"282300","name":"Polarity and subcellular dynamics in plants","call_identifier":"FP7"},{"_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020"}],"publication":"The Plant Cell","volume":30,"day":"12","month":"11","language":[{"iso":"eng"}],"corr_author":"1","publication_status":"published","external_id":{"isi":["000450000500023"],"pmid":["30018156"]},"department":[{"_id":"JiFr"}],"status":"public","author":[{"full_name":"Kania, Urszula","last_name":"Kania","first_name":"Urszula","id":"4AE5C486-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Tomasz","last_name":"Nodzyński","full_name":"Nodzyński, Tomasz"},{"first_name":"Qing","last_name":"Lu","full_name":"Lu, Qing"},{"last_name":"Hicks","full_name":"Hicks, Glenn R","first_name":"Glenn R"},{"first_name":"Wim","full_name":"Nerinckx, Wim","last_name":"Nerinckx"},{"last_name":"Mishev","full_name":"Mishev, Kiril","first_name":"Kiril"},{"first_name":"Francois","full_name":"Peurois, Francois","last_name":"Peurois"},{"last_name":"Cherfils","full_name":"Cherfils, Jacqueline","first_name":"Jacqueline"},{"full_name":"De, Rycke Riet Maria","last_name":"De","first_name":"Rycke Riet Maria"},{"last_name":"Grones","full_name":"Grones, Peter","id":"399876EC-F248-11E8-B48F-1D18A9856A87","first_name":"Peter"},{"last_name":"Robert","full_name":"Robert, Stéphanie","first_name":"Stéphanie"},{"first_name":"Eugenia","full_name":"Russinova, Eugenia","last_name":"Russinova"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","last_name":"Friml"}],"publisher":"Oxford University Press","intvolume":"        30","year":"2018","pmid":1,"ec_funded":1,"publication_identifier":{"issn":["1040-4651"]},"ddc":["580"],"date_created":"2018-12-11T11:44:52Z","quality_controlled":"1","isi":1,"date_published":"2018-11-12T00:00:00Z","scopus_import":"1","article_type":"original","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1105/tpc.18.00127"}],"issue":"10","title":"The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with sub cellular trafficking in eukaryotes"},{"publication":"Cell","publist_id":"7774","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","grant_number":"742985","call_identifier":"H2020","_id":"261099A6-B435-11E9-9278-68D0E5697425"}],"type":"journal_article","_id":"148","doi":"10.1016/j.cell.2018.06.033","abstract":[{"text":"Land plants evolved from charophytic algae, among which Charophyceae possess the most complex body plans. We present the genome of Chara braunii; comparison of the genome to those of land plants identified evolutionary novelties for plant terrestrialization and land plant heritage genes. C. braunii employs unique xylan synthases for cell wall biosynthesis, a phragmoplast (cell separation) mechanism similar to that of land plants, and many phytohormones. C. braunii plastids are controlled via land-plant-like retrograde signaling, and transcriptional regulation is more elaborate than in other algae. The morphological complexity of this organism may result from expanded gene families, with three cases of particular note: genes effecting tolerance to reactive oxygen species (ROS), LysM receptor-like kinases, and transcription factors (TFs). Transcriptomic analysis of sexual reproductive structures reveals intricate control by TFs, activity of the ROS gene network, and the ancestral use of plant-like storage and stress protection proteins in the zygote.","lang":"eng"}],"article_processing_charge":"No","oa_version":"Published Version","page":"448 - 464.e24","citation":{"short":"T. Nishiyama, H. Sakayama, J. De Vries, H. Buschmann, D. Saint Marcoux, K. Ullrich, F. Haas, L. Vanderstraeten, D. Becker, D. Lang, S. Vosolsobě, S. Rombauts, P. Wilhelmsson, P. Janitza, R. Kern, A. Heyl, F. Rümpler, L. Calderón Villalobos, J. Clay, R. Skokan, A. Toyoda, Y. Suzuki, H. Kagoshima, E. Schijlen, N. Tajeshwar, B. Catarino, A. Hetherington, A. Saltykova, C. Bonnot, H. Breuninger, A. Symeonidi, G. Radhakrishnan, F. Van Nieuwerburgh, D. Deforce, C. Chang, K. Karol, R. Hedrich, P. Ulvskov, G. Glöckner, C. Delwiche, J. Petrášek, Y. Van De Peer, J. Friml, M. Beilby, L. Dolan, Y. Kohara, S. Sugano, A. Fujiyama, P.M. Delaux, M. Quint, G. Theissen, M. Hagemann, J. Harholt, C. Dunand, S. Zachgo, J. Langdale, F. Maumus, D. Van Der Straeten, S.B. Gould, S. Rensing, Cell 174 (2018) 448–464.e24.","ista":"Nishiyama T, Sakayama H, De Vries J, Buschmann H, Saint Marcoux D, Ullrich K, Haas F, Vanderstraeten L, Becker D, Lang D, Vosolsobě S, Rombauts S, Wilhelmsson P, Janitza P, Kern R, Heyl A, Rümpler F, Calderón Villalobos L, Clay J, Skokan R, Toyoda A, Suzuki Y, Kagoshima H, Schijlen E, Tajeshwar N, Catarino B, Hetherington A, Saltykova A, Bonnot C, Breuninger H, Symeonidi A, Radhakrishnan G, Van Nieuwerburgh F, Deforce D, Chang C, Karol K, Hedrich R, Ulvskov P, Glöckner G, Delwiche C, Petrášek J, Van De Peer Y, Friml J, Beilby M, Dolan L, Kohara Y, Sugano S, Fujiyama A, Delaux PM, Quint M, Theissen G, Hagemann M, Harholt J, Dunand C, Zachgo S, Langdale J, Maumus F, Van Der Straeten D, Gould SB, Rensing S. 2018. The Chara genome: Secondary complexity and implications for plant terrestrialization. Cell. 174(2), 448–464.e24.","apa":"Nishiyama, T., Sakayama, H., De Vries, J., Buschmann, H., Saint Marcoux, D., Ullrich, K., … Rensing, S. (2018). The Chara genome: Secondary complexity and implications for plant terrestrialization. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cell.2018.06.033\">https://doi.org/10.1016/j.cell.2018.06.033</a>","ieee":"T. Nishiyama <i>et al.</i>, “The Chara genome: Secondary complexity and implications for plant terrestrialization,” <i>Cell</i>, vol. 174, no. 2. Cell Press, p. 448–464.e24, 2018.","ama":"Nishiyama T, Sakayama H, De Vries J, et al. The Chara genome: Secondary complexity and implications for plant terrestrialization. <i>Cell</i>. 2018;174(2):448-464.e24. doi:<a href=\"https://doi.org/10.1016/j.cell.2018.06.033\">10.1016/j.cell.2018.06.033</a>","mla":"Nishiyama, Tomoaki, et al. “The Chara Genome: Secondary Complexity and Implications for Plant Terrestrialization.” <i>Cell</i>, vol. 174, no. 2, Cell Press, 2018, p. 448–464.e24, doi:<a href=\"https://doi.org/10.1016/j.cell.2018.06.033\">10.1016/j.cell.2018.06.033</a>.","chicago":"Nishiyama, Tomoaki, Hidetoshi Sakayama, Jan De Vries, Henrik Buschmann, Denis Saint Marcoux, Kristian Ullrich, Fabian Haas, et al. “The Chara Genome: Secondary Complexity and Implications for Plant Terrestrialization.” <i>Cell</i>. Cell Press, 2018. <a href=\"https://doi.org/10.1016/j.cell.2018.06.033\">https://doi.org/10.1016/j.cell.2018.06.033</a>."},"date_updated":"2026-06-18T17:39:09Z","oa":1,"acknowledgement":"In-Data-Review","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"07","language":[{"iso":"eng"}],"volume":174,"day":"12","status":"public","department":[{"_id":"JiFr"}],"external_id":{"pmid":["30007417"],"isi":["000438482800019"]},"publication_status":"published","issue":"2","title":"The Chara genome: Secondary complexity and implications for plant terrestrialization","scopus_import":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pubmed/30007417","open_access":"1"}],"date_published":"2018-07-12T00:00:00Z","ddc":["580"],"date_created":"2018-12-11T11:44:53Z","quality_controlled":"1","isi":1,"pmid":1,"ec_funded":1,"intvolume":"       174","year":"2018","author":[{"last_name":"Nishiyama","full_name":"Nishiyama, Tomoaki","first_name":"Tomoaki"},{"last_name":"Sakayama","full_name":"Sakayama, Hidetoshi","first_name":"Hidetoshi"},{"last_name":"De Vries","full_name":"De Vries, Jan","first_name":"Jan"},{"last_name":"Buschmann","full_name":"Buschmann, Henrik","first_name":"Henrik"},{"last_name":"Saint Marcoux","full_name":"Saint Marcoux, Denis","first_name":"Denis"},{"full_name":"Ullrich, Kristian","last_name":"Ullrich","first_name":"Kristian"},{"first_name":"Fabian","full_name":"Haas, Fabian","last_name":"Haas"},{"first_name":"Lisa","last_name":"Vanderstraeten","full_name":"Vanderstraeten, Lisa"},{"first_name":"Dirk","last_name":"Becker","full_name":"Becker, Dirk"},{"last_name":"Lang","full_name":"Lang, Daniel","first_name":"Daniel"},{"first_name":"Stanislav","last_name":"Vosolsobě","full_name":"Vosolsobě, Stanislav"},{"first_name":"Stephane","last_name":"Rombauts","full_name":"Rombauts, Stephane"},{"full_name":"Wilhelmsson, Per","last_name":"Wilhelmsson","first_name":"Per"},{"first_name":"Philipp","full_name":"Janitza, Philipp","last_name":"Janitza"},{"first_name":"Ramona","last_name":"Kern","full_name":"Kern, Ramona"},{"last_name":"Heyl","full_name":"Heyl, Alexander","first_name":"Alexander"},{"last_name":"Rümpler","full_name":"Rümpler, Florian","first_name":"Florian"},{"first_name":"Luz","full_name":"Calderón Villalobos, Luz","last_name":"Calderón Villalobos"},{"first_name":"John","full_name":"Clay, John","last_name":"Clay"},{"first_name":"Roman","last_name":"Skokan","full_name":"Skokan, Roman"},{"full_name":"Toyoda, Atsushi","last_name":"Toyoda","first_name":"Atsushi"},{"full_name":"Suzuki, Yutaka","last_name":"Suzuki","first_name":"Yutaka"},{"full_name":"Kagoshima, Hiroshi","last_name":"Kagoshima","first_name":"Hiroshi"},{"first_name":"Elio","full_name":"Schijlen, Elio","last_name":"Schijlen"},{"first_name":"Navindra","last_name":"Tajeshwar","full_name":"Tajeshwar, Navindra"},{"last_name":"Catarino","full_name":"Catarino, Bruno","first_name":"Bruno"},{"first_name":"Alexander","full_name":"Hetherington, Alexander","last_name":"Hetherington"},{"full_name":"Saltykova, Assia","last_name":"Saltykova","first_name":"Assia"},{"full_name":"Bonnot, Clemence","last_name":"Bonnot","first_name":"Clemence"},{"last_name":"Breuninger","full_name":"Breuninger, Holger","first_name":"Holger"},{"last_name":"Symeonidi","full_name":"Symeonidi, Aikaterini","first_name":"Aikaterini"},{"full_name":"Radhakrishnan, Guru","last_name":"Radhakrishnan","first_name":"Guru"},{"full_name":"Van Nieuwerburgh, Filip","last_name":"Van Nieuwerburgh","first_name":"Filip"},{"first_name":"Dieter","full_name":"Deforce, Dieter","last_name":"Deforce"},{"first_name":"Caren","last_name":"Chang","full_name":"Chang, Caren"},{"first_name":"Kenneth","last_name":"Karol","full_name":"Karol, Kenneth"},{"last_name":"Hedrich","full_name":"Hedrich, Rainer","first_name":"Rainer"},{"last_name":"Ulvskov","full_name":"Ulvskov, Peter","first_name":"Peter"},{"first_name":"Gernot","full_name":"Glöckner, Gernot","last_name":"Glöckner"},{"full_name":"Delwiche, Charles","last_name":"Delwiche","first_name":"Charles"},{"first_name":"Jan","last_name":"Petrášek","full_name":"Petrášek, Jan"},{"full_name":"Van De Peer, Yves","last_name":"Van De Peer","first_name":"Yves"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jirí"},{"first_name":"Mary","full_name":"Beilby, Mary","last_name":"Beilby"},{"last_name":"Dolan","full_name":"Dolan, Liam","first_name":"Liam"},{"first_name":"Yuji","full_name":"Kohara, Yuji","last_name":"Kohara"},{"first_name":"Sumio","last_name":"Sugano","full_name":"Sugano, Sumio"},{"last_name":"Fujiyama","full_name":"Fujiyama, Asao","first_name":"Asao"},{"last_name":"Delaux","full_name":"Delaux, Pierre Marc","first_name":"Pierre Marc"},{"first_name":"Marcel","full_name":"Quint, Marcel","last_name":"Quint"},{"first_name":"Gunter","last_name":"Theissen","full_name":"Theissen, Gunter"},{"last_name":"Hagemann","full_name":"Hagemann, Martin","first_name":"Martin"},{"first_name":"Jesper","full_name":"Harholt, Jesper","last_name":"Harholt"},{"first_name":"Christophe","last_name":"Dunand","full_name":"Dunand, Christophe"},{"first_name":"Sabine","full_name":"Zachgo, Sabine","last_name":"Zachgo"},{"first_name":"Jane","last_name":"Langdale","full_name":"Langdale, Jane"},{"first_name":"Florian","last_name":"Maumus","full_name":"Maumus, Florian"},{"first_name":"Dominique","last_name":"Van Der Straeten","full_name":"Van Der Straeten, Dominique"},{"first_name":"Sven B","last_name":"Gould","full_name":"Gould, Sven B"},{"last_name":"Rensing","full_name":"Rensing, Stefan","first_name":"Stefan"}],"publisher":"Cell Press"},{"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242333/","open_access":"1"}],"scopus_import":"1","article_type":"original","issue":"7719","title":"Inositol phosphates are assembly co-factors for HIV-1","date_published":"2018-08-29T00:00:00Z","related_material":{"link":[{"url":"https://doi.org/10.1038/s41586-018-0505-4","relation":"erratum"}]},"publication_identifier":{"eissn":["1476-4687"]},"pmid":1,"date_created":"2018-12-11T11:44:53Z","isi":1,"quality_controlled":"1","publisher":"Nature Publishing Group","author":[{"last_name":"Dick","full_name":"Dick, Robert","first_name":"Robert"},{"full_name":"Zadrozny, Kaneil K","last_name":"Zadrozny","first_name":"Kaneil K"},{"last_name":"Xu","full_name":"Xu, Chaoyi","first_name":"Chaoyi"},{"first_name":"Florian","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","full_name":"Schur, Florian","orcid":"0000-0003-4790-8078","last_name":"Schur"},{"full_name":"Lyddon, Terri D","last_name":"Lyddon","first_name":"Terri D"},{"first_name":"Clifton L","full_name":"Ricana, Clifton L","last_name":"Ricana"},{"first_name":"Jonathan M","full_name":"Wagner, Jonathan M","last_name":"Wagner"},{"full_name":"Perilla, Juan R","last_name":"Perilla","first_name":"Juan R"},{"first_name":"Pornillos Barbie K","last_name":"Ganser","full_name":"Ganser, Pornillos Barbie K"},{"full_name":"Johnson, Marc C","last_name":"Johnson","first_name":"Marc C"},{"last_name":"Pornillos","full_name":"Pornillos, Owen","first_name":"Owen"},{"last_name":"Vogt","full_name":"Vogt, Volker","first_name":"Volker"}],"year":"2018","intvolume":"       560","status":"public","external_id":{"pmid":["30158708"],"isi":["000442483400046"]},"publication_status":"published","department":[{"_id":"FlSc"}],"month":"08","language":[{"iso":"eng"}],"day":"29","volume":560,"publication":"Nature","article_processing_charge":"No","oa_version":"Submitted Version","_id":"150","doi":"10.1038/s41586-018-0396-4","abstract":[{"text":"A short, 14-amino-acid segment called SP1, located in the Gag structural protein1, has a critical role during the formation of the HIV-1 virus particle. During virus assembly, the SP1 peptide and seven preceding residues fold into a six-helix bundle, which holds together the Gag hexamer and facilitates the formation of a curved immature hexagonal lattice underneath the viral membrane2,3. Upon completion of assembly and budding, proteolytic cleavage of Gag leads to virus maturation, in which the immature lattice is broken down; the liberated CA domain of Gag then re-assembles into the mature conical capsid that encloses the viral genome and associated enzymes. Folding and proteolysis of the six-helix bundle are crucial rate-limiting steps of both Gag assembly and disassembly, and the six-helix bundle is an established target of HIV-1 inhibitors4,5. Here, using a combination of structural and functional analyses, we show that inositol hexakisphosphate (InsP6, also known as IP6) facilitates the formation of the six-helix bundle and assembly of the immature HIV-1 Gag lattice. IP6 makes ionic contacts with two rings of lysine residues at the centre of the Gag hexamer. Proteolytic cleavage then unmasks an alternative binding site, where IP6 interaction promotes the assembly of the mature capsid lattice. These studies identify IP6 as a naturally occurring small molecule that promotes both assembly and maturation of HIV-1.","lang":"eng"}],"type":"journal_article","citation":{"short":"R. Dick, K.K. Zadrozny, C. Xu, F.K. Schur, T.D. Lyddon, C.L. Ricana, J.M. Wagner, J.R. Perilla, P.B.K. Ganser, M.C. Johnson, O. Pornillos, V. Vogt, Nature 560 (2018) 509–512.","apa":"Dick, R., Zadrozny, K. K., Xu, C., Schur, F. K., Lyddon, T. D., Ricana, C. L., … Vogt, V. (2018). Inositol phosphates are assembly co-factors for HIV-1. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41586-018-0396-4\">https://doi.org/10.1038/s41586-018-0396-4</a>","ista":"Dick R, Zadrozny KK, Xu C, Schur FK, Lyddon TD, Ricana CL, Wagner JM, Perilla JR, Ganser PBK, Johnson MC, Pornillos O, Vogt V. 2018. Inositol phosphates are assembly co-factors for HIV-1. Nature. 560(7719), 509–512.","ieee":"R. Dick <i>et al.</i>, “Inositol phosphates are assembly co-factors for HIV-1,” <i>Nature</i>, vol. 560, no. 7719. Nature Publishing Group, pp. 509–512, 2018.","ama":"Dick R, Zadrozny KK, Xu C, et al. Inositol phosphates are assembly co-factors for HIV-1. <i>Nature</i>. 2018;560(7719):509–512. doi:<a href=\"https://doi.org/10.1038/s41586-018-0396-4\">10.1038/s41586-018-0396-4</a>","mla":"Dick, Robert, et al. “Inositol Phosphates Are Assembly Co-Factors for HIV-1.” <i>Nature</i>, vol. 560, no. 7719, Nature Publishing Group, 2018, pp. 509–512, doi:<a href=\"https://doi.org/10.1038/s41586-018-0396-4\">10.1038/s41586-018-0396-4</a>.","chicago":"Dick, Robert, Kaneil K Zadrozny, Chaoyi Xu, Florian KM Schur, Terri D Lyddon, Clifton L Ricana, Jonathan M Wagner, et al. “Inositol Phosphates Are Assembly Co-Factors for HIV-1.” <i>Nature</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41586-018-0396-4\">https://doi.org/10.1038/s41586-018-0396-4</a>."},"page":"509–512","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-12T07:44:37Z"},{"_id":"15107","doi":"10.1021/acs.chemmater.8b03108","article_processing_charge":"No","oa_version":"None","type":"journal_article","status":"public","publication":"Chemistry of Materials","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","date_updated":"2024-03-20T07:50:07Z","publication_status":"published","page":"8415-8419","citation":{"chicago":"Roy, Soumendu, Sumit Roy, Anish Rao, Gayathri Devatha, and Pramod P. Pillai. “Precise Nanoparticle–Reactant Interaction Outplays Ligand Poisoning in Visible-Light Photocatalysis.” <i>Chemistry of Materials</i>. American Chemical Society, 2018. <a href=\"https://doi.org/10.1021/acs.chemmater.8b03108\">https://doi.org/10.1021/acs.chemmater.8b03108</a>.","mla":"Roy, Soumendu, et al. “Precise Nanoparticle–Reactant Interaction Outplays Ligand Poisoning in Visible-Light Photocatalysis.” <i>Chemistry of Materials</i>, vol. 30, no. 23, American Chemical Society, 2018, pp. 8415–19, doi:<a href=\"https://doi.org/10.1021/acs.chemmater.8b03108\">10.1021/acs.chemmater.8b03108</a>.","ama":"Roy S, Roy S, Rao A, Devatha G, Pillai PP. Precise nanoparticle–reactant interaction outplays ligand poisoning in visible-light photocatalysis. <i>Chemistry of Materials</i>. 2018;30(23):8415-8419. doi:<a href=\"https://doi.org/10.1021/acs.chemmater.8b03108\">10.1021/acs.chemmater.8b03108</a>","ieee":"S. Roy, S. Roy, A. Rao, G. Devatha, and P. P. Pillai, “Precise nanoparticle–reactant interaction outplays ligand poisoning in visible-light photocatalysis,” <i>Chemistry of Materials</i>, vol. 30, no. 23. American Chemical Society, pp. 8415–8419, 2018.","ista":"Roy S, Roy S, Rao A, Devatha G, Pillai PP. 2018. Precise nanoparticle–reactant interaction outplays ligand poisoning in visible-light photocatalysis. Chemistry of Materials. 30(23), 8415–8419.","apa":"Roy, S., Roy, S., Rao, A., Devatha, G., &#38; Pillai, P. P. (2018). Precise nanoparticle–reactant interaction outplays ligand poisoning in visible-light photocatalysis. <i>Chemistry of Materials</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.chemmater.8b03108\">https://doi.org/10.1021/acs.chemmater.8b03108</a>","short":"S. Roy, S. Roy, A. Rao, G. Devatha, P.P. Pillai, Chemistry of Materials 30 (2018) 8415–8419."},"date_published":"2018-11-19T00:00:00Z","article_type":"review","scopus_import":"1","title":"Precise nanoparticle–reactant interaction outplays ligand poisoning in visible-light photocatalysis","issue":"23","author":[{"last_name":"Roy","full_name":"Roy, Soumendu","first_name":"Soumendu"},{"id":"67a1dc7d-cffb-11ee-b082-e15ca6a616d9","first_name":"Sumit","last_name":"Roy","full_name":"Roy, Sumit","orcid":"0000-0002-6883-4939"},{"first_name":"Anish","last_name":"Rao","full_name":"Rao, Anish"},{"last_name":"Devatha","full_name":"Devatha, Gayathri","first_name":"Gayathri"},{"first_name":"Pramod P.","last_name":"Pillai","full_name":"Pillai, Pramod P."}],"publisher":"American Chemical Society","volume":30,"intvolume":"        30","keyword":["Materials Chemistry","General Chemical Engineering","General Chemistry"],"year":"2018","day":"19","publication_identifier":{"eissn":["1520-5002"],"issn":["0897-4756"]},"quality_controlled":"1","language":[{"iso":"eng"}],"month":"11","date_created":"2024-03-12T12:54:30Z"},{"issue":"15","title":"Stability of local secondary structure determines selectivity of viral RNA chaperones","main_file_link":[{"url":"https://doi.org/10.1093/nar/gky394","open_access":"1"}],"scopus_import":"1","article_type":"original","date_published":"2018-09-06T00:00:00Z","date_created":"2024-03-20T10:43:13Z","quality_controlled":"1","publication_identifier":{"issn":["0305-1048"],"eissn":["1362-4962"]},"pmid":1,"keyword":["Genetics"],"year":"2018","intvolume":"        46","publisher":"Oxford University Press","author":[{"id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","first_name":"Jack Peter Kelly","last_name":"Bravo","full_name":"Bravo, Jack Peter Kelly","orcid":"0000-0003-0456-0753"},{"first_name":"Alexander","last_name":"Borodavka","full_name":"Borodavka, Alexander"},{"first_name":"Anders","last_name":"Barth","full_name":"Barth, Anders"},{"full_name":"Calabrese, Antonio N","last_name":"Calabrese","first_name":"Antonio N"},{"full_name":"Mojzes, Peter","last_name":"Mojzes","first_name":"Peter"},{"full_name":"Cockburn, Joseph J B","last_name":"Cockburn","first_name":"Joseph J B"},{"first_name":"Don C","full_name":"Lamb, Don C","last_name":"Lamb"},{"full_name":"Tuma, Roman","last_name":"Tuma","first_name":"Roman"}],"status":"public","publication_status":"published","external_id":{"pmid":["29796667"]},"extern":"1","month":"09","language":[{"iso":"eng"}],"day":"06","volume":46,"publication":"Nucleic Acids Research","type":"journal_article","article_processing_charge":"Yes","oa_version":"Published Version","_id":"15143","doi":"10.1093/nar/gky394","abstract":[{"lang":"eng","text":"To maintain genome integrity, segmented double-stranded RNA viruses of the Reoviridae family must accurately select and package a complete set of up to a dozen distinct genomic RNAs. It is thought that the high fidelity segmented genome assembly involves multiple sequence-specific RNA–RNA interactions between single-stranded RNA segment precursors. These are mediated by virus-encoded non-structural proteins with RNA chaperone-like activities, such as rotavirus (RV) NSP2 and avian reovirus σNS. Here, we compared the abilities of NSP2 and σNS to mediate sequence-specific interactions between RV genomic segment precursors. Despite their similar activities, NSP2 successfully promotes inter-segment association, while σNS fails to do so. To understand the mechanisms underlying such selectivity in promoting inter-molecular duplex formation, we compared RNA-binding and helix-unwinding activities of both proteins. We demonstrate that octameric NSP2 binds structured RNAs with high affinity, resulting in efficient intramolecular RNA helix disruption. Hexameric σNS oligomerizes into an octamer that binds two RNAs, yet it exhibits only limited RNA-unwinding activity compared to NSP2. Thus, the formation of intersegment RNA–RNA interactions is governed by both helix-unwinding capacity of the chaperones and stability of RNA structure. We propose that this protein-mediated RNA selection mechanism may underpin the high fidelity assembly of multi-segmented RNA genomes in Reoviridae."}],"citation":{"ieee":"J. P. K. Bravo <i>et al.</i>, “Stability of local secondary structure determines selectivity of viral RNA chaperones,” <i>Nucleic Acids Research</i>, vol. 46, no. 15. Oxford University Press, pp. 7924–7937, 2018.","short":"J.P.K. Bravo, A. Borodavka, A. Barth, A.N. Calabrese, P. Mojzes, J.J.B. Cockburn, D.C. Lamb, R. Tuma, Nucleic Acids Research 46 (2018) 7924–7937.","ista":"Bravo JPK, Borodavka A, Barth A, Calabrese AN, Mojzes P, Cockburn JJB, Lamb DC, Tuma R. 2018. Stability of local secondary structure determines selectivity of viral RNA chaperones. Nucleic Acids Research. 46(15), 7924–7937.","apa":"Bravo, J. P. K., Borodavka, A., Barth, A., Calabrese, A. N., Mojzes, P., Cockburn, J. J. B., … Tuma, R. (2018). Stability of local secondary structure determines selectivity of viral RNA chaperones. <i>Nucleic Acids Research</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/nar/gky394\">https://doi.org/10.1093/nar/gky394</a>","mla":"Bravo, Jack Peter Kelly, et al. “Stability of Local Secondary Structure Determines Selectivity of Viral RNA Chaperones.” <i>Nucleic Acids Research</i>, vol. 46, no. 15, Oxford University Press, 2018, pp. 7924–37, doi:<a href=\"https://doi.org/10.1093/nar/gky394\">10.1093/nar/gky394</a>.","chicago":"Bravo, Jack Peter Kelly, Alexander Borodavka, Anders Barth, Antonio N Calabrese, Peter Mojzes, Joseph J B Cockburn, Don C Lamb, and Roman Tuma. “Stability of Local Secondary Structure Determines Selectivity of Viral RNA Chaperones.” <i>Nucleic Acids Research</i>. Oxford University Press, 2018. <a href=\"https://doi.org/10.1093/nar/gky394\">https://doi.org/10.1093/nar/gky394</a>.","ama":"Bravo JPK, Borodavka A, Barth A, et al. Stability of local secondary structure determines selectivity of viral RNA chaperones. <i>Nucleic Acids Research</i>. 2018;46(15):7924-7937. doi:<a href=\"https://doi.org/10.1093/nar/gky394\">10.1093/nar/gky394</a>"},"page":"7924-7937","date_updated":"2024-04-09T11:07:07Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1},{"author":[{"full_name":"Fiedorczuk, Karol","last_name":"Fiedorczuk","first_name":"Karol","id":"5BFF67CE-02D1-11E9-B11A-A5A4D7DFFFD0"},{"last_name":"Sazanov","orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A"}],"publisher":"Elsevier","intvolume":"        28","year":"2018","ddc":["572"],"isi":1,"quality_controlled":"1","date_created":"2018-12-11T11:44:54Z","date_published":"2018-07-26T00:00:00Z","article_type":"original","scopus_import":"1","issue":"10","title":"Mammalian mitochondrial complex I structure and disease causing mutations","external_id":{"isi":["000445118200007"]},"publication_status":"published","department":[{"_id":"LeSa"}],"has_accepted_license":"1","file":[{"date_created":"2019-11-07T12:55:20Z","file_name":"SasanovFinalMS+EdComments_LS_allacc_withFigs.pdf","content_type":"application/pdf","date_updated":"2020-07-14T12:45:00Z","access_level":"open_access","file_id":"6994","file_size":2185385,"creator":"lsazanov","checksum":"ef6d2b4e1fd63948539639242610bfa6","relation":"main_file"}],"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"volume":28,"day":"26","language":[{"iso":"eng"}],"month":"07","file_date_updated":"2020-07-14T12:45:00Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1,"date_updated":"2023-09-13T08:51:56Z","page":"835 - 867","citation":{"short":"K. Fiedorczuk, L.A. Sazanov, Trends in Cell Biology 28 (2018) 835–867.","ista":"Fiedorczuk K, Sazanov LA. 2018. Mammalian mitochondrial complex I structure and disease causing mutations. Trends in Cell Biology. 28(10), 835–867.","apa":"Fiedorczuk, K., &#38; Sazanov, L. A. (2018). Mammalian mitochondrial complex I structure and disease causing mutations. <i>Trends in Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tcb.2018.06.006\">https://doi.org/10.1016/j.tcb.2018.06.006</a>","ieee":"K. Fiedorczuk and L. A. Sazanov, “Mammalian mitochondrial complex I structure and disease causing mutations,” <i>Trends in Cell Biology</i>, vol. 28, no. 10. Elsevier, pp. 835–867, 2018.","ama":"Fiedorczuk K, Sazanov LA. Mammalian mitochondrial complex I structure and disease causing mutations. <i>Trends in Cell Biology</i>. 2018;28(10):835-867. doi:<a href=\"https://doi.org/10.1016/j.tcb.2018.06.006\">10.1016/j.tcb.2018.06.006</a>","mla":"Fiedorczuk, Karol, and Leonid A. Sazanov. “Mammalian Mitochondrial Complex I Structure and Disease Causing Mutations.” <i>Trends in Cell Biology</i>, vol. 28, no. 10, Elsevier, 2018, pp. 835–67, doi:<a href=\"https://doi.org/10.1016/j.tcb.2018.06.006\">10.1016/j.tcb.2018.06.006</a>.","chicago":"Fiedorczuk, Karol, and Leonid A Sazanov. “Mammalian Mitochondrial Complex I Structure and Disease Causing Mutations.” <i>Trends in Cell Biology</i>. Elsevier, 2018. <a href=\"https://doi.org/10.1016/j.tcb.2018.06.006\">https://doi.org/10.1016/j.tcb.2018.06.006</a>."},"_id":"152","doi":"10.1016/j.tcb.2018.06.006","abstract":[{"text":"Complex I has an essential role in ATP production by coupling electron transfer from NADH to quinone with translocation of protons across the inner mitochondrial membrane. Isolated complex I deficiency is a frequent cause of mitochondrial inherited diseases. Complex I has also been implicated in cancer, ageing, and neurodegenerative conditions. Until recently, the understanding of complex I deficiency on the molecular level was limited due to the lack of high-resolution structures of the enzyme. However, due to developments in single particle cryo-electron microscopy (cryo-EM), recent studies have reported nearly atomic resolution maps and models of mitochondrial complex I. These structures significantly add to our understanding of complex I mechanism and assembly. The disease-causing mutations are discussed here in their structural context.","lang":"eng"}],"oa_version":"Submitted Version","article_processing_charge":"No","publist_id":"7769","type":"journal_article","publication":"Trends in Cell Biology"},{"month":"12","language":[{"iso":"eng"}],"day":"07","volume":62,"citation":{"ieee":"A. D. Rosa <i>et al.</i>, “Accretion in strong field gravity with eXTP,” <i>Science China Physics, Mechanics &#38; Astronomy</i>, vol. 62, no. 2. Springer Nature, 2018.","ista":"Rosa AD et al. 2018. Accretion in strong field gravity with eXTP. Science China Physics, Mechanics &#38; Astronomy. 62(2), 29504.","apa":"Rosa, A. D., Uttley, P., Gou, L., Liu, Y., Bambi, C., Barret, D., … Zhou, X. (2018). Accretion in strong field gravity with eXTP. <i>Science China Physics, Mechanics &#38; Astronomy</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11433-018-9297-0\">https://doi.org/10.1007/s11433-018-9297-0</a>","short":"A.D. Rosa, P. Uttley, L. Gou, Y. Liu, C. Bambi, D. Barret, T. Belloni, E. Berti, S. Bianchi, I. Caiazzo, P. Casella, M. Feroci, V. Ferrari, L. Gualtieri, J. Heyl, A. Ingram, V. Karas, F. Lu, B. Luo, G. Matt, S. Motta, J. Neilsen, P. Pani, A. Santangelo, X. Shu, J. Wang, J.-M. Wang, Y. Xue, Y. Xu, W. Yuan, Y. Yuan, S.-N. Zhang, S. Zhang, I. Agudo, L. Amati, N. Andersson, C. Baglio, P. Bakala, A. Baykal, S. Bhattacharyya, I. Bombaci, N. Bucciantini, F. Capitanio, R. Ciolfi, W.K. Cui, F. D’Ammando, T. Dauser, M. Del Santo, B. De Marco, T. Di Salvo, C. Done, M. Dovčiak, A.C. Fabian, M. Falanga, A.F. Gambino, B. Gendre, V. Grinberg, A. Heger, J. Homan, R. Iaria, J. Jiang, C. Jin, E. Koerding, M. Linares, Z. Liu, T.J. Maccarone, J. Malzac, A. Manousakis, F. Marin, A. Marinucci, M. Mehdipour, M. Méndez, S. Migliari, C. Miller, G. Miniutti, E. Nardini, P.T. O’Brien, J.P. Osborne, P.O. Petrucci, A. Possenti, A. Riggio, J. Rodriguez, A. Sanna, L. Shao, M. Sobolewska, E. Sramkova, A.L. Stevens, H. Stiele, G. Stratta, Z. Stuchlik, J. Svoboda, F. Tamburini, T.M. Tauris, F. Tombesi, G. Torok, M. Urbanec, F. Vincent, Q. Wu, F. Yuan, J.J.M. in’ t Zand, A.A. Zdziarski, X. Zhou, Science China Physics, Mechanics &#38; Astronomy 62 (2018).","chicago":"Rosa, Alessandra De, Phil Uttley, LiJun Gou, Yuan Liu, Cosimo Bambi, Didier Barret, Tomaso Belloni, et al. “Accretion in Strong Field Gravity with EXTP.” <i>Science China Physics, Mechanics &#38; Astronomy</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1007/s11433-018-9297-0\">https://doi.org/10.1007/s11433-018-9297-0</a>.","mla":"Rosa, Alessandra De, et al. “Accretion in Strong Field Gravity with EXTP.” <i>Science China Physics, Mechanics &#38; Astronomy</i>, vol. 62, no. 2, 29504, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1007/s11433-018-9297-0\">10.1007/s11433-018-9297-0</a>.","ama":"Rosa AD, Uttley P, Gou L, et al. Accretion in strong field gravity with eXTP. <i>Science China Physics, Mechanics &#38; Astronomy</i>. 2018;62(2). doi:<a href=\"https://doi.org/10.1007/s11433-018-9297-0\">10.1007/s11433-018-9297-0</a>"},"date_updated":"2024-04-05T07:12:09Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","oa":1,"publication":"Science China Physics, Mechanics & Astronomy","type":"journal_article","oa_version":"Preprint","article_processing_charge":"No","_id":"15232","abstract":[{"text":"In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry (eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced “spectral-timing-polarimetry” techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process. ","lang":"eng"}],"doi":"10.1007/s11433-018-9297-0","date_created":"2024-03-26T10:37:41Z","quality_controlled":"1","publication_identifier":{"eissn":["1869-1927"],"issn":["1674-7348"]},"keyword":["General Physics and Astronomy"],"year":"2018","intvolume":"        62","publisher":"Springer Nature","author":[{"first_name":"Alessandra De","last_name":"Rosa","full_name":"Rosa, Alessandra De"},{"first_name":"Phil","last_name":"Uttley","full_name":"Uttley, Phil"},{"first_name":"LiJun","last_name":"Gou","full_name":"Gou, LiJun"},{"full_name":"Liu, Yuan","last_name":"Liu","first_name":"Yuan"},{"last_name":"Bambi","full_name":"Bambi, Cosimo","first_name":"Cosimo"},{"first_name":"Didier","last_name":"Barret","full_name":"Barret, Didier"},{"last_name":"Belloni","full_name":"Belloni, Tomaso","first_name":"Tomaso"},{"first_name":"Emanuele","full_name":"Berti, Emanuele","last_name":"Berti"},{"full_name":"Bianchi, Stefano","last_name":"Bianchi","first_name":"Stefano"},{"id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","first_name":"Ilaria","full_name":"Caiazzo, Ilaria","last_name":"Caiazzo","orcid":"0000-0002-4770-5388"},{"full_name":"Casella, Piergiorgio","last_name":"Casella","first_name":"Piergiorgio"},{"last_name":"Feroci","full_name":"Feroci, Marco","first_name":"Marco"},{"full_name":"Ferrari, Valeria","last_name":"Ferrari","first_name":"Valeria"},{"first_name":"Leonardo","full_name":"Gualtieri, Leonardo","last_name":"Gualtieri"},{"first_name":"Jeremy","last_name":"Heyl","full_name":"Heyl, Jeremy"},{"last_name":"Ingram","full_name":"Ingram, Adam","first_name":"Adam"},{"last_name":"Karas","full_name":"Karas, Vladimir","first_name":"Vladimir"},{"first_name":"FangJun","last_name":"Lu","full_name":"Lu, FangJun"},{"last_name":"Luo","full_name":"Luo, Bin","first_name":"Bin"},{"first_name":"Giorgio","last_name":"Matt","full_name":"Matt, Giorgio"},{"last_name":"Motta","full_name":"Motta, Sara","first_name":"Sara"},{"full_name":"Neilsen, Joseph","last_name":"Neilsen","first_name":"Joseph"},{"first_name":"Paolo","full_name":"Pani, Paolo","last_name":"Pani"},{"last_name":"Santangelo","full_name":"Santangelo, Andrea","first_name":"Andrea"},{"first_name":"XinWen","last_name":"Shu","full_name":"Shu, XinWen"},{"full_name":"Wang, JunFeng","last_name":"Wang","first_name":"JunFeng"},{"full_name":"Wang, Jian-Min","last_name":"Wang","first_name":"Jian-Min"},{"first_name":"YongQuan","full_name":"Xue, YongQuan","last_name":"Xue"},{"first_name":"YuPeng","last_name":"Xu","full_name":"Xu, YuPeng"},{"last_name":"Yuan","full_name":"Yuan, WeiMin","first_name":"WeiMin"},{"first_name":"YeFei","full_name":"Yuan, YeFei","last_name":"Yuan"},{"first_name":"Shuang-Nan","last_name":"Zhang","full_name":"Zhang, Shuang-Nan"},{"last_name":"Zhang","full_name":"Zhang, Shu","first_name":"Shu"},{"last_name":"Agudo","full_name":"Agudo, Ivan","first_name":"Ivan"},{"last_name":"Amati","full_name":"Amati, Lorenzo","first_name":"Lorenzo"},{"full_name":"Andersson, Nils","last_name":"Andersson","first_name":"Nils"},{"first_name":"Cristina","last_name":"Baglio","full_name":"Baglio, Cristina"},{"first_name":"Pavel","last_name":"Bakala","full_name":"Bakala, Pavel"},{"last_name":"Baykal","full_name":"Baykal, Altan","first_name":"Altan"},{"full_name":"Bhattacharyya, Sudip","last_name":"Bhattacharyya","first_name":"Sudip"},{"first_name":"Ignazio","last_name":"Bombaci","full_name":"Bombaci, Ignazio"},{"full_name":"Bucciantini, Niccoló","last_name":"Bucciantini","first_name":"Niccoló"},{"full_name":"Capitanio, Fiamma","last_name":"Capitanio","first_name":"Fiamma"},{"last_name":"Ciolfi","full_name":"Ciolfi, Riccardo","first_name":"Riccardo"},{"first_name":"Wei K.","last_name":"Cui","full_name":"Cui, Wei K."},{"first_name":"Filippo","last_name":"D’Ammando","full_name":"D’Ammando, Filippo"},{"last_name":"Dauser","full_name":"Dauser, Thomas","first_name":"Thomas"},{"last_name":"Del Santo","full_name":"Del Santo, Melania","first_name":"Melania"},{"first_name":"Barbara","last_name":"De Marco","full_name":"De Marco, Barbara"},{"first_name":"Tiziana","last_name":"Di Salvo","full_name":"Di Salvo, Tiziana"},{"last_name":"Done","full_name":"Done, Chris","first_name":"Chris"},{"first_name":"Michal","full_name":"Dovčiak, Michal","last_name":"Dovčiak"},{"full_name":"Fabian, Andrew C.","last_name":"Fabian","first_name":"Andrew C."},{"first_name":"Maurizio","last_name":"Falanga","full_name":"Falanga, Maurizio"},{"first_name":"Angelo Francesco","full_name":"Gambino, Angelo Francesco","last_name":"Gambino"},{"first_name":"Bruce","full_name":"Gendre, Bruce","last_name":"Gendre"},{"full_name":"Grinberg, Victoria","last_name":"Grinberg","first_name":"Victoria"},{"first_name":"Alexander","full_name":"Heger, Alexander","last_name":"Heger"},{"last_name":"Homan","full_name":"Homan, Jeroen","first_name":"Jeroen"},{"full_name":"Iaria, Rosario","last_name":"Iaria","first_name":"Rosario"},{"full_name":"Jiang, JiaChen","last_name":"Jiang","first_name":"JiaChen"},{"first_name":"ChiChuan","last_name":"Jin","full_name":"Jin, ChiChuan"},{"first_name":"Elmar","last_name":"Koerding","full_name":"Koerding, Elmar"},{"full_name":"Linares, Manu","last_name":"Linares","first_name":"Manu"},{"full_name":"Liu, Zhu","last_name":"Liu","first_name":"Zhu"},{"full_name":"Maccarone, Thomas J.","last_name":"Maccarone","first_name":"Thomas J."},{"first_name":"Julien","full_name":"Malzac, Julien","last_name":"Malzac"},{"full_name":"Manousakis, Antonios","last_name":"Manousakis","first_name":"Antonios"},{"first_name":"Frédéric","full_name":"Marin, Frédéric","last_name":"Marin"},{"first_name":"Andrea","full_name":"Marinucci, Andrea","last_name":"Marinucci"},{"first_name":"Missagh","last_name":"Mehdipour","full_name":"Mehdipour, Missagh"},{"first_name":"Mariano","full_name":"Méndez, Mariano","last_name":"Méndez"},{"first_name":"Simone","last_name":"Migliari","full_name":"Migliari, Simone"},{"first_name":"Cole","full_name":"Miller, Cole","last_name":"Miller"},{"last_name":"Miniutti","full_name":"Miniutti, Giovanni","first_name":"Giovanni"},{"last_name":"Nardini","full_name":"Nardini, Emanuele","first_name":"Emanuele"},{"last_name":"O’Brien","full_name":"O’Brien, Paul T.","first_name":"Paul T."},{"first_name":"Julian P.","full_name":"Osborne, Julian P.","last_name":"Osborne"},{"first_name":"Pierre Olivier","last_name":"Petrucci","full_name":"Petrucci, Pierre Olivier"},{"first_name":"Andrea","full_name":"Possenti, Andrea","last_name":"Possenti"},{"first_name":"Alessandro","full_name":"Riggio, Alessandro","last_name":"Riggio"},{"full_name":"Rodriguez, Jerome","last_name":"Rodriguez","first_name":"Jerome"},{"last_name":"Sanna","full_name":"Sanna, Andrea","first_name":"Andrea"},{"first_name":"LiJing","last_name":"Shao","full_name":"Shao, LiJing"},{"full_name":"Sobolewska, Malgosia","last_name":"Sobolewska","first_name":"Malgosia"},{"last_name":"Sramkova","full_name":"Sramkova, Eva","first_name":"Eva"},{"first_name":"Abigail L.","full_name":"Stevens, Abigail L.","last_name":"Stevens"},{"last_name":"Stiele","full_name":"Stiele, Holger","first_name":"Holger"},{"first_name":"Giulia","full_name":"Stratta, Giulia","last_name":"Stratta"},{"full_name":"Stuchlik, Zdenek","last_name":"Stuchlik","first_name":"Zdenek"},{"full_name":"Svoboda, Jiri","last_name":"Svoboda","first_name":"Jiri"},{"last_name":"Tamburini","full_name":"Tamburini, Fabrizio","first_name":"Fabrizio"},{"last_name":"Tauris","full_name":"Tauris, Thomas M.","first_name":"Thomas M."},{"full_name":"Tombesi, Francesco","last_name":"Tombesi","first_name":"Francesco"},{"first_name":"Gabriel","last_name":"Torok","full_name":"Torok, Gabriel"},{"first_name":"Martin","full_name":"Urbanec, Martin","last_name":"Urbanec"},{"first_name":"Frederic","last_name":"Vincent","full_name":"Vincent, Frederic"},{"first_name":"QingWen","last_name":"Wu","full_name":"Wu, QingWen"},{"last_name":"Yuan","full_name":"Yuan, Feng","first_name":"Feng"},{"last_name":"in’ t Zand","full_name":"in’ t Zand, Jean J. M.","first_name":"Jean J. M."},{"last_name":"Zdziarski","full_name":"Zdziarski, Andrzej A.","first_name":"Andrzej A."},{"first_name":"XinLin","full_name":"Zhou, XinLin","last_name":"Zhou"}],"title":"Accretion in strong field gravity with eXTP","issue":"2","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1812.04022","open_access":"1"}],"scopus_import":"1","article_type":"original","date_published":"2018-12-07T00:00:00Z","external_id":{"arxiv":["1812.04022"]},"publication_status":"published","extern":"1","article_number":"29504","status":"public","arxiv":1},{"language":[{"iso":"eng"}],"month":"10","volume":62,"day":"08","citation":{"ieee":"A. Santangelo <i>et al.</i>, “Physics and astrophysics of strong magnetic field systems with eXTP,” <i>Science China Physics, Mechanics &#38; Astronomy</i>, vol. 62, no. 2. Springer Nature, 2018.","apa":"Santangelo, A., Zane, S., Feng, H., Xu, R., Doroshenko, V., Bozzo, E., … Zhan, S.-N. (2018). Physics and astrophysics of strong magnetic field systems with eXTP. <i>Science China Physics, Mechanics &#38; Astronomy</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11433-018-9234-3\">https://doi.org/10.1007/s11433-018-9234-3</a>","ista":"Santangelo A, Zane S, Feng H, Xu R, Doroshenko V, Bozzo E, Caiazzo I, Zelati FC, Esposito P, González-Caniulef D, Heyl J, Huppenkothen D, Israel G, Li Z, Lin L, Mignani R, Rea N, Orlandini M, Taverna R, Tong H, Turolla R, Baglio C, Bernardini F, Bucciantini N, Feroci M, Fürst F, Göğüş E, Güngör C, Ji L, Lu F, Manousakis A, Mereghetti S, Mikusincova R, Paul B, Prescod-Weinstein C, Younes G, Tiengo A, Xu Y, Watts A, Zhang S, Zhan S-N. 2018. Physics and astrophysics of strong magnetic field systems with eXTP. Science China Physics, Mechanics &#38; Astronomy. 62(2), 29505.","short":"A. Santangelo, S. Zane, H. Feng, R. Xu, V. Doroshenko, E. Bozzo, I. Caiazzo, F.C. Zelati, P. Esposito, D. González-Caniulef, J. Heyl, D. Huppenkothen, G. Israel, Z. Li, L. Lin, R. Mignani, N. Rea, M. Orlandini, R. Taverna, H. Tong, R. Turolla, C. Baglio, F. Bernardini, N. Bucciantini, M. Feroci, F. Fürst, E. Göğüş, C. Güngör, L. Ji, F. Lu, A. Manousakis, S. Mereghetti, R. Mikusincova, B. Paul, C. Prescod-Weinstein, G. Younes, A. Tiengo, Y. Xu, A. Watts, S. Zhang, S.-N. Zhan, Science China Physics, Mechanics &#38; Astronomy 62 (2018).","chicago":"Santangelo, Andrea, Silvia Zane, Hua Feng, RenXin Xu, Victor Doroshenko, Enrico Bozzo, Ilaria Caiazzo, et al. “Physics and Astrophysics of Strong Magnetic Field Systems with EXTP.” <i>Science China Physics, Mechanics &#38; Astronomy</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1007/s11433-018-9234-3\">https://doi.org/10.1007/s11433-018-9234-3</a>.","mla":"Santangelo, Andrea, et al. “Physics and Astrophysics of Strong Magnetic Field Systems with EXTP.” <i>Science China Physics, Mechanics &#38; Astronomy</i>, vol. 62, no. 2, 29505, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1007/s11433-018-9234-3\">10.1007/s11433-018-9234-3</a>.","ama":"Santangelo A, Zane S, Feng H, et al. Physics and astrophysics of strong magnetic field systems with eXTP. <i>Science China Physics, Mechanics &#38; Astronomy</i>. 2018;62(2). doi:<a href=\"https://doi.org/10.1007/s11433-018-9234-3\">10.1007/s11433-018-9234-3</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"date_updated":"2024-04-08T07:01:20Z","publication":"Science China Physics, Mechanics & Astronomy","_id":"15233","doi":"10.1007/s11433-018-9234-3","abstract":[{"text":"In this paper we present the science potential of the enhanced X-ray Timing and Polarimetry (eXTP) mission for studies of strongly magnetized objects. We will focus on the physics and astrophysics of strongly magnetized objects, namely magnetars, accreting X-ray pulsars, and rotation powered pulsars. We also discuss the science potential of eXTP for QED studies. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020s.","lang":"eng"}],"article_processing_charge":"No","oa_version":"Preprint","type":"journal_article","publication_identifier":{"eissn":["1869-1927"],"issn":["1674-7348"]},"date_created":"2024-03-26T10:38:05Z","quality_controlled":"1","author":[{"first_name":"Andrea","full_name":"Santangelo, Andrea","last_name":"Santangelo"},{"first_name":"Silvia","full_name":"Zane, Silvia","last_name":"Zane"},{"full_name":"Feng, Hua","last_name":"Feng","first_name":"Hua"},{"full_name":"Xu, RenXin","last_name":"Xu","first_name":"RenXin"},{"full_name":"Doroshenko, Victor","last_name":"Doroshenko","first_name":"Victor"},{"last_name":"Bozzo","full_name":"Bozzo, Enrico","first_name":"Enrico"},{"id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","first_name":"Ilaria","last_name":"Caiazzo","full_name":"Caiazzo, Ilaria","orcid":"0000-0002-4770-5388"},{"first_name":"Francesco Coti","last_name":"Zelati","full_name":"Zelati, Francesco Coti"},{"first_name":"Paolo","full_name":"Esposito, Paolo","last_name":"Esposito"},{"first_name":"Denis","full_name":"González-Caniulef, Denis","last_name":"González-Caniulef"},{"last_name":"Heyl","full_name":"Heyl, Jeremy","first_name":"Jeremy"},{"full_name":"Huppenkothen, Daniela","last_name":"Huppenkothen","first_name":"Daniela"},{"full_name":"Israel, Gianluca","last_name":"Israel","first_name":"Gianluca"},{"last_name":"Li","full_name":"Li, ZhaoSheng","first_name":"ZhaoSheng"},{"first_name":"Lin","full_name":"Lin, Lin","last_name":"Lin"},{"last_name":"Mignani","full_name":"Mignani, Roberto","first_name":"Roberto"},{"full_name":"Rea, Nanda","last_name":"Rea","first_name":"Nanda"},{"first_name":"Mauro","last_name":"Orlandini","full_name":"Orlandini, Mauro"},{"first_name":"Roberto","last_name":"Taverna","full_name":"Taverna, Roberto"},{"first_name":"Hao","last_name":"Tong","full_name":"Tong, Hao"},{"first_name":"Roberto","full_name":"Turolla, Roberto","last_name":"Turolla"},{"full_name":"Baglio, Cristina","last_name":"Baglio","first_name":"Cristina"},{"full_name":"Bernardini, Federico","last_name":"Bernardini","first_name":"Federico"},{"first_name":"Niccolo’","last_name":"Bucciantini","full_name":"Bucciantini, Niccolo’"},{"first_name":"Marco","full_name":"Feroci, Marco","last_name":"Feroci"},{"last_name":"Fürst","full_name":"Fürst, Felix","first_name":"Felix"},{"first_name":"Ersin","full_name":"Göğüş, Ersin","last_name":"Göğüş"},{"first_name":"Can","full_name":"Güngör, Can","last_name":"Güngör"},{"first_name":"Long","full_name":"Ji, Long","last_name":"Ji"},{"first_name":"FangJun","last_name":"Lu","full_name":"Lu, FangJun"},{"last_name":"Manousakis","full_name":"Manousakis, Antonios","first_name":"Antonios"},{"full_name":"Mereghetti, Sandro","last_name":"Mereghetti","first_name":"Sandro"},{"last_name":"Mikusincova","full_name":"Mikusincova, Romana","first_name":"Romana"},{"first_name":"Biswajit","last_name":"Paul","full_name":"Paul, Biswajit"},{"last_name":"Prescod-Weinstein","full_name":"Prescod-Weinstein, Chanda","first_name":"Chanda"},{"full_name":"Younes, George","last_name":"Younes","first_name":"George"},{"first_name":"Andrea","full_name":"Tiengo, Andrea","last_name":"Tiengo"},{"first_name":"YuPeng","last_name":"Xu","full_name":"Xu, YuPeng"},{"first_name":"Anna","last_name":"Watts","full_name":"Watts, Anna"},{"full_name":"Zhang, Shu","last_name":"Zhang","first_name":"Shu"},{"first_name":"Shuang-Nan","full_name":"Zhan, Shuang-Nan","last_name":"Zhan"}],"publisher":"Springer Nature","intvolume":"        62","keyword":["General Physics and Astronomy"],"year":"2018","scopus_import":"1","article_type":"original","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1812.04460"}],"issue":"2","title":"Physics and astrophysics of strong magnetic field systems with eXTP","date_published":"2018-10-08T00:00:00Z","publication_status":"published","external_id":{"arxiv":["1812.04460"]},"extern":"1","article_number":"29505","status":"public","arxiv":1},{"arxiv":1,"status":"public","article_number":"132","extern":"1","external_id":{"arxiv":["1807.07089"]},"publication_status":"published","date_published":"2018-11-07T00:00:00Z","article_type":"original","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1807.07089"}],"issue":"2","title":"Distances to the globular clusters 47 Tucanae and NGC 362 using Gaia DR2 parallaxes","author":[{"full_name":"Chen, Seery","last_name":"Chen","first_name":"Seery"},{"first_name":"Harvey","last_name":"Richer","full_name":"Richer, Harvey"},{"first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","last_name":"Caiazzo","orcid":"0000-0002-4770-5388","full_name":"Caiazzo, Ilaria"},{"first_name":"Jeremy","last_name":"Heyl","full_name":"Heyl, Jeremy"}],"publisher":"American Astronomical Society","intvolume":"       867","year":"2018","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"publication_identifier":{"eissn":["1538-4357"],"issn":["0004-637X"]},"date_created":"2024-03-26T10:38:28Z","quality_controlled":"1","doi":"10.3847/1538-4357/aae089","_id":"15234","abstract":[{"lang":"eng","text":"Using parallaxes from Gaia Data Release 2 (Gaia DR2), we estimate the distance to the globular clusters 47 Tuc and NGC 362, taking advantage of the background stars in the Small Magellanic Cloud and quasars to account for various parallax systematics. We found the parallax to be dependent on the Gaia DR2 G-band apparent magnitude for stars with 13 < G < 18, where brighter stars have a lower parallax zero point than fainter stars. The distance to 47 Tuc was found to be 4.45 ± 0.01 ± 0.12 kpc, and for NGC 362 8.54 ± 0.20 ± 0.44 kpc, with random and systematic errors listed, respectively. This is the first time a precise distance measurement directly using parallaxes has been determined for either of these two globular clusters."}],"article_processing_charge":"No","oa_version":"Preprint","type":"journal_article","publication":"The Astrophysical Journal","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"date_updated":"2024-04-08T07:01:51Z","citation":{"ama":"Chen S, Richer H, Caiazzo I, Heyl J. Distances to the globular clusters 47 Tucanae and NGC 362 using Gaia DR2 parallaxes. <i>The Astrophysical Journal</i>. 2018;867(2). doi:<a href=\"https://doi.org/10.3847/1538-4357/aae089\">10.3847/1538-4357/aae089</a>","mla":"Chen, Seery, et al. “Distances to the Globular Clusters 47 Tucanae and NGC 362 Using Gaia DR2 Parallaxes.” <i>The Astrophysical Journal</i>, vol. 867, no. 2, 132, American Astronomical Society, 2018, doi:<a href=\"https://doi.org/10.3847/1538-4357/aae089\">10.3847/1538-4357/aae089</a>.","chicago":"Chen, Seery, Harvey Richer, Ilaria Caiazzo, and Jeremy Heyl. “Distances to the Globular Clusters 47 Tucanae and NGC 362 Using Gaia DR2 Parallaxes.” <i>The Astrophysical Journal</i>. American Astronomical Society, 2018. <a href=\"https://doi.org/10.3847/1538-4357/aae089\">https://doi.org/10.3847/1538-4357/aae089</a>.","short":"S. Chen, H. Richer, I. Caiazzo, J. Heyl, The Astrophysical Journal 867 (2018).","apa":"Chen, S., Richer, H., Caiazzo, I., &#38; Heyl, J. (2018). Distances to the globular clusters 47 Tucanae and NGC 362 using Gaia DR2 parallaxes. <i>The Astrophysical Journal</i>. American Astronomical Society. <a href=\"https://doi.org/10.3847/1538-4357/aae089\">https://doi.org/10.3847/1538-4357/aae089</a>","ista":"Chen S, Richer H, Caiazzo I, Heyl J. 2018. Distances to the globular clusters 47 Tucanae and NGC 362 using Gaia DR2 parallaxes. The Astrophysical Journal. 867(2), 132.","ieee":"S. Chen, H. Richer, I. Caiazzo, and J. Heyl, “Distances to the globular clusters 47 Tucanae and NGC 362 using Gaia DR2 parallaxes,” <i>The Astrophysical Journal</i>, vol. 867, no. 2. American Astronomical Society, 2018."},"volume":867,"day":"07","language":[{"iso":"eng"}],"month":"11"},{"date_created":"2024-03-26T10:38:46Z","quality_controlled":"1","publication_identifier":{"eissn":["2075-4434"]},"intvolume":"         6","year":"2018","keyword":["Astronomy and Astrophysics"],"author":[{"first_name":"Jeremy","last_name":"Heyl","full_name":"Heyl, Jeremy"},{"first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","orcid":"0000-0002-4770-5388","full_name":"Caiazzo, Ilaria","last_name":"Caiazzo"}],"publisher":"MDPI","issue":"3","title":"Strongly magnetized sources: QED and X-ray polarization","scopus_import":"1","article_type":"original","main_file_link":[{"open_access":"1","url":"https://doi.org/10.3390/galaxies6030076"}],"date_published":"2018-07-21T00:00:00Z","external_id":{"arxiv":["1802.00358"]},"publication_status":"published","extern":"1","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","article_number":"76","arxiv":1,"language":[{"iso":"eng"}],"month":"07","volume":6,"day":"21","citation":{"ieee":"J. Heyl and I. Caiazzo, “Strongly magnetized sources: QED and X-ray polarization,” <i>Galaxies</i>, vol. 6, no. 3. MDPI, 2018.","apa":"Heyl, J., &#38; Caiazzo, I. (2018). Strongly magnetized sources: QED and X-ray polarization. <i>Galaxies</i>. MDPI. <a href=\"https://doi.org/10.3390/galaxies6030076\">https://doi.org/10.3390/galaxies6030076</a>","ista":"Heyl J, Caiazzo I. 2018. Strongly magnetized sources: QED and X-ray polarization. Galaxies. 6(3), 76.","short":"J. Heyl, I. Caiazzo, Galaxies 6 (2018).","chicago":"Heyl, Jeremy, and Ilaria Caiazzo. “Strongly Magnetized Sources: QED and X-Ray Polarization.” <i>Galaxies</i>. MDPI, 2018. <a href=\"https://doi.org/10.3390/galaxies6030076\">https://doi.org/10.3390/galaxies6030076</a>.","mla":"Heyl, Jeremy, and Ilaria Caiazzo. “Strongly Magnetized Sources: QED and X-Ray Polarization.” <i>Galaxies</i>, vol. 6, no. 3, 76, MDPI, 2018, doi:<a href=\"https://doi.org/10.3390/galaxies6030076\">10.3390/galaxies6030076</a>.","ama":"Heyl J, Caiazzo I. Strongly magnetized sources: QED and X-ray polarization. <i>Galaxies</i>. 2018;6(3). doi:<a href=\"https://doi.org/10.3390/galaxies6030076\">10.3390/galaxies6030076</a>"},"date_updated":"2024-04-08T07:02:25Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"publication":"Galaxies","type":"journal_article","doi":"10.3390/galaxies6030076","_id":"15235","abstract":[{"lang":"eng","text":"Radiative corrections of quantum electrodynamics cause a vacuum threaded by a magnetic field to be birefringent. This means that radiation of different polarizations travels at different speeds. Even in the strong magnetic fields of astrophysical sources, the difference in speed is small. However, it has profound consequences for the extent of polarization expected from strongly magnetized sources. We demonstrate how the birefringence arises from first principles, show how birefringence affects the polarization state of radiation and present recent calculations for the expected polarization from magnetars and X-ray pulsars."}],"oa_version":"Published Version","article_processing_charge":"No"},{"type":"journal_article","article_processing_charge":"No","oa_version":"Preprint","doi":"10.1093/mnras/sty482","_id":"15236","abstract":[{"text":"Radio pulsars found in binary systems with short orbital periods are usually fast spinning as a consequence of recycling via mass transfer from their companion stars; this process is also thought to decrease the magnetic field of the neutron star being recycled. Here, we report on timing observations of the recently discovered binary PSR J1755−2550 and find that this pulsar is an exception: with a characteristic age of 2.1 Myr, it is relatively young; furthermore, with a spin period of 315 ms and a surface magnetic field strength at its poles of 0.88 × 1012 G, the pulsar shows no sign of having been recycled. Based on its timing and orbital characteristics, the pulsar either has a massive white dwarf (WD) or a neutron star (NS) companion. To distinguish between these two cases, we searched radio observations for a potential recycled pulsar companion and analysed archival optical data for a potential WD companion. Neither work returned conclusive detections. We apply population synthesis modelling and find that both solutions are roughly equally probable. Our population synthesis also predicts a minimum mass of 0.90 M⊙ for the companion star to PSR J1755−2550 and we simulate the systemic runaway velocities for the resulting WDNS systems which may merge and possibly produce Ca-rich supernovae. Whether PSR J1755−2550 hosts a WD or a NS companion star, it is certainly a member of a rare subpopulation of binary radio pulsars.","lang":"eng"}],"publication":"Monthly Notices of the Royal Astronomical Society","date_updated":"2024-04-08T07:02:52Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"citation":{"ama":"Ng C, Kruckow MU, Tauris TM, et al. PSR J1755−2550: A young radio pulsar with a massive, compact companion. <i>Monthly Notices of the Royal Astronomical Society</i>. 2018;476(4):4315-4326. doi:<a href=\"https://doi.org/10.1093/mnras/sty482\">10.1093/mnras/sty482</a>","mla":"Ng, C., et al. “PSR J1755−2550: A Young Radio Pulsar with a Massive, Compact Companion.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 476, no. 4, Oxford University Press, 2018, pp. 4315–26, doi:<a href=\"https://doi.org/10.1093/mnras/sty482\">10.1093/mnras/sty482</a>.","chicago":"Ng, C, M U Kruckow, T M Tauris, A G Lyne, P C C Freire, A Ridolfi, Ilaria Caiazzo, et al. “PSR J1755−2550: A Young Radio Pulsar with a Massive, Compact Companion.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2018. <a href=\"https://doi.org/10.1093/mnras/sty482\">https://doi.org/10.1093/mnras/sty482</a>.","short":"C. Ng, M.U. Kruckow, T.M. Tauris, A.G. Lyne, P.C.C. Freire, A. Ridolfi, I. Caiazzo, J. Heyl, M. Kramer, A.D. Cameron, D.J. Champion, B. Stappers, Monthly Notices of the Royal Astronomical Society 476 (2018) 4315–4326.","apa":"Ng, C., Kruckow, M. U., Tauris, T. M., Lyne, A. G., Freire, P. C. C., Ridolfi, A., … Stappers, B. (2018). PSR J1755−2550: A young radio pulsar with a massive, compact companion. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/sty482\">https://doi.org/10.1093/mnras/sty482</a>","ista":"Ng C, Kruckow MU, Tauris TM, Lyne AG, Freire PCC, Ridolfi A, Caiazzo I, Heyl J, Kramer M, Cameron AD, Champion DJ, Stappers B. 2018. PSR J1755−2550: A young radio pulsar with a massive, compact companion. Monthly Notices of the Royal Astronomical Society. 476(4), 4315–4326.","ieee":"C. Ng <i>et al.</i>, “PSR J1755−2550: A young radio pulsar with a massive, compact companion,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 476, no. 4. Oxford University Press, pp. 4315–4326, 2018."},"page":"4315-4326","day":"23","volume":476,"language":[{"iso":"eng"}],"month":"02","arxiv":1,"status":"public","extern":"1","external_id":{"arxiv":["1802.08248"]},"publication_status":"published","date_published":"2018-02-23T00:00:00Z","issue":"4","title":"PSR J1755−2550: A young radio pulsar with a massive, compact companion","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1802.08248"}],"scopus_import":"1","article_type":"original","year":"2018","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"intvolume":"       476","publisher":"Oxford University Press","author":[{"full_name":"Ng, C","last_name":"Ng","first_name":"C"},{"last_name":"Kruckow","full_name":"Kruckow, M U","first_name":"M U"},{"first_name":"T M","full_name":"Tauris, T M","last_name":"Tauris"},{"full_name":"Lyne, A G","last_name":"Lyne","first_name":"A G"},{"full_name":"Freire, P C C","last_name":"Freire","first_name":"P C C"},{"first_name":"A","full_name":"Ridolfi, A","last_name":"Ridolfi"},{"full_name":"Caiazzo, Ilaria","last_name":"Caiazzo","orcid":"0000-0002-4770-5388","first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d"},{"full_name":"Heyl, J","last_name":"Heyl","first_name":"J"},{"first_name":"M","full_name":"Kramer, M","last_name":"Kramer"},{"first_name":"A D","full_name":"Cameron, A D","last_name":"Cameron"},{"first_name":"D J","full_name":"Champion, D J","last_name":"Champion"},{"first_name":"B","full_name":"Stappers, B","last_name":"Stappers"}],"date_created":"2024-03-26T10:39:05Z","quality_controlled":"1","publication_identifier":{"issn":["0035-8711"],"eissn":["1365-2966"]}},{"citation":{"short":"I. Caiazzo, J. Heyl, Galaxies 6 (2018).","ista":"Caiazzo I, Heyl J. 2018. Probing black hole magnetic fields with QED. Galaxies. 6(2), 57.","apa":"Caiazzo, I., &#38; Heyl, J. (2018). Probing black hole magnetic fields with QED. <i>Galaxies</i>. MDPI. <a href=\"https://doi.org/10.3390/galaxies6020057\">https://doi.org/10.3390/galaxies6020057</a>","ieee":"I. Caiazzo and J. Heyl, “Probing black hole magnetic fields with QED,” <i>Galaxies</i>, vol. 6, no. 2. MDPI, 2018.","ama":"Caiazzo I, Heyl J. Probing black hole magnetic fields with QED. <i>Galaxies</i>. 2018;6(2). doi:<a href=\"https://doi.org/10.3390/galaxies6020057\">10.3390/galaxies6020057</a>","mla":"Caiazzo, Ilaria, and Jeremy Heyl. “Probing Black Hole Magnetic Fields with QED.” <i>Galaxies</i>, vol. 6, no. 2, 57, MDPI, 2018, doi:<a href=\"https://doi.org/10.3390/galaxies6020057\">10.3390/galaxies6020057</a>.","chicago":"Caiazzo, Ilaria, and Jeremy Heyl. “Probing Black Hole Magnetic Fields with QED.” <i>Galaxies</i>. MDPI, 2018. <a href=\"https://doi.org/10.3390/galaxies6020057\">https://doi.org/10.3390/galaxies6020057</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"date_updated":"2024-10-14T12:33:20Z","publication":"Galaxies","doi":"10.3390/galaxies6020057","_id":"15237","abstract":[{"text":"The effect of vacuum birefringence is one of the first predictions of quantum electrodynamics (QED): the presence of a charged Dirac field makes the vacuum birefringent when threaded by magnetic fields. This effect, extremely weak for terrestrial magnetic fields, becomes important for highly magnetized astrophysical objects, such as accreting black holes. In the X-ray regime, the polarization of photons traveling in the magnetosphere of a black hole is not frozen at emission but is changed by the local magnetic field. We show that, for photons traveling along the plane of the disk, where the field is expected to be partially organized, this results in a depolarization of the X-ray radiation. Because the amount of depolarization depends on the strength of the magnetic field, this effect can provide a way to probe the magnetic field in black-hole accretion disks and to study the role of magnetic fields in astrophysical accretion in general.","lang":"eng"}],"article_processing_charge":"No","oa_version":"Published Version","type":"journal_article","language":[{"iso":"eng"}],"month":"05","volume":6,"day":"24","publication_status":"published","external_id":{"arxiv":["1805.11018"]},"extern":"1","status":"public","article_number":"57","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"arxiv":1,"publication_identifier":{"eissn":["2075-4434"]},"quality_controlled":"1","date_created":"2024-03-26T10:39:26Z","author":[{"full_name":"Caiazzo, Ilaria","orcid":"0000-0002-4770-5388","last_name":"Caiazzo","first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d"},{"full_name":"Heyl, Jeremy","last_name":"Heyl","first_name":"Jeremy"}],"publisher":"MDPI","intvolume":"         6","keyword":["Astronomy and Astrophysics"],"year":"2018","article_type":"original","scopus_import":"1","main_file_link":[{"url":"https://doi.org/10.3390/galaxies6020057","open_access":"1"}],"title":"Probing black hole magnetic fields with QED","issue":"2","date_published":"2018-05-24T00:00:00Z"},{"citation":{"mla":"Caiazzo, Ilaria, and Jeremy Heyl. “Vacuum Birefringence and the X-Ray Polarization from Black-Hole Accretion Disks.” <i>Physical Review D</i>, vol. 97, no. 8, 083001, American Physical Society, 2018, doi:<a href=\"https://doi.org/10.1103/physrevd.97.083001\">10.1103/physrevd.97.083001</a>.","chicago":"Caiazzo, Ilaria, and Jeremy Heyl. “Vacuum Birefringence and the X-Ray Polarization from Black-Hole Accretion Disks.” <i>Physical Review D</i>. American Physical Society, 2018. <a href=\"https://doi.org/10.1103/physrevd.97.083001\">https://doi.org/10.1103/physrevd.97.083001</a>.","ama":"Caiazzo I, Heyl J. Vacuum birefringence and the x-ray polarization from black-hole accretion disks. <i>Physical Review D</i>. 2018;97(8). doi:<a href=\"https://doi.org/10.1103/physrevd.97.083001\">10.1103/physrevd.97.083001</a>","ieee":"I. Caiazzo and J. Heyl, “Vacuum birefringence and the x-ray polarization from black-hole accretion disks,” <i>Physical Review D</i>, vol. 97, no. 8. American Physical Society, 2018.","short":"I. Caiazzo, J. Heyl, Physical Review D 97 (2018).","apa":"Caiazzo, I., &#38; Heyl, J. (2018). Vacuum birefringence and the x-ray polarization from black-hole accretion disks. <i>Physical Review D</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevd.97.083001\">https://doi.org/10.1103/physrevd.97.083001</a>","ista":"Caiazzo I, Heyl J. 2018. Vacuum birefringence and the x-ray polarization from black-hole accretion disks. Physical Review D. 97(8), 083001."},"date_updated":"2024-10-14T12:33:32Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"publication":"Physical Review D","type":"journal_article","abstract":[{"text":"In the next decade, x-ray polarimetry will open a new window on the high-energy Universe, as several missions that include an x-ray polarimeter are currently under development. Observations of the polarization of x rays coming from the accretion disks of stellar-mass and supermassive black holes are among the new polarimeters’ major objectives. In this paper, we show that these observations can be affected by the quantum electrodynamic (QED) effect of vacuum birefringence: after an x-ray photon is emitted from the accretion disk, its polarization changes as the photon travels through the accretion disk’s magnetosphere, as a result of the vacuum becoming birefringent in the presence of a magnetic field. We show that this effect can be important for black holes in the energy band of the upcoming polarimeters and has to be taken into account in a complete model of the x-ray polarization that we expect to detect from black-hole accretion disks, both for stellar mass and for supermassive black holes. We find that, for a chaotic magnetic field in the disk, QED can significantly decrease the linear polarization fraction of edge-on photons, depending on the spin of the hole and on the strength of the magnetic field. This effect can provide, for the first time, a direct way to probe the magnetic field strength close to the innermost stable orbit of black-hole accretion disks and to study the role of magnetic fields in astrophysical accretion in general.","lang":"eng"}],"_id":"15238","doi":"10.1103/physrevd.97.083001","article_processing_charge":"No","oa_version":"Preprint","month":"04","language":[{"iso":"eng"}],"volume":97,"day":"03","publication_status":"published","external_id":{"arxiv":["1803.03798"]},"extern":"1","status":"public","article_number":"083001","arxiv":1,"date_created":"2024-03-26T10:39:46Z","quality_controlled":"1","publication_identifier":{"issn":["2470-0010"],"eissn":["2470-0029"]},"intvolume":"        97","year":"2018","author":[{"last_name":"Caiazzo","full_name":"Caiazzo, Ilaria","orcid":"0000-0002-4770-5388","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","first_name":"Ilaria"},{"last_name":"Heyl","full_name":"Heyl, Jeremy","first_name":"Jeremy"}],"publisher":"American Physical Society","issue":"8","title":"Vacuum birefringence and the x-ray polarization from black-hole accretion disks","scopus_import":"1","article_type":"original","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1803.03798","open_access":"1"}],"date_published":"2018-04-03T00:00:00Z"},{"external_id":{"isi":["000452412300006"],"pmid":["30165964"]},"publication_status":"published","department":[{"_id":"MiSi"},{"_id":"NanoFab"}],"status":"public","publisher":"Academic Press","author":[{"first_name":"Jörg","id":"3F0587C8-F248-11E8-B48F-1D18A9856A87","last_name":"Renkawitz","full_name":"Renkawitz, Jörg","orcid":"0000-0003-2856-3369"},{"id":"35B76592-F248-11E8-B48F-1D18A9856A87","first_name":"Anne","orcid":"0000-0003-0666-8928","full_name":"Reversat, Anne","last_name":"Reversat"},{"last_name":"Leithner","orcid":"0000-0002-1073-744X","full_name":"Leithner, Alexander F","first_name":"Alexander F","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-5145-4609","full_name":"Merrin, Jack","last_name":"Merrin","first_name":"Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-6620-9179","last_name":"Sixt","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K"}],"year":"2018","intvolume":"       147","publication_identifier":{"issn":["0091-679X"]},"pmid":1,"isi":1,"date_created":"2018-12-11T11:44:54Z","quality_controlled":"1","date_published":"2018-07-27T00:00:00Z","scopus_import":"1","title":"Micro-engineered “pillar forests” to study cell migration in complex but controlled 3D environments","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-07-10T11:51:09Z","citation":{"apa":"Renkawitz, J., Reversat, A., Leithner, A. F., Merrin, J., &#38; Sixt, M. K. (2018). Micro-engineered “pillar forests” to study cell migration in complex but controlled 3D environments. In <i>Methods in Cell Biology</i> (Vol. 147, pp. 79–91). Academic Press. <a href=\"https://doi.org/10.1016/bs.mcb.2018.07.004\">https://doi.org/10.1016/bs.mcb.2018.07.004</a>","ista":"Renkawitz J, Reversat A, Leithner AF, Merrin J, Sixt MK. 2018.Micro-engineered “pillar forests” to study cell migration in complex but controlled 3D environments. In: Methods in Cell Biology. vol. 147, 79–91.","short":"J. Renkawitz, A. Reversat, A.F. Leithner, J. Merrin, M.K. Sixt, in:, Methods in Cell Biology, Academic Press, 2018, pp. 79–91.","ieee":"J. Renkawitz, A. Reversat, A. F. Leithner, J. Merrin, and M. K. Sixt, “Micro-engineered ‘pillar forests’ to study cell migration in complex but controlled 3D environments,” in <i>Methods in Cell Biology</i>, vol. 147, Academic Press, 2018, pp. 79–91.","ama":"Renkawitz J, Reversat A, Leithner AF, Merrin J, Sixt MK. Micro-engineered “pillar forests” to study cell migration in complex but controlled 3D environments. In: <i>Methods in Cell Biology</i>. Vol 147. Academic Press; 2018:79-91. doi:<a href=\"https://doi.org/10.1016/bs.mcb.2018.07.004\">10.1016/bs.mcb.2018.07.004</a>","chicago":"Renkawitz, Jörg, Anne Reversat, Alexander F Leithner, Jack Merrin, and Michael K Sixt. “Micro-Engineered ‘Pillar Forests’ to Study Cell Migration in Complex but Controlled 3D Environments.” In <i>Methods in Cell Biology</i>, 147:79–91. Academic Press, 2018. <a href=\"https://doi.org/10.1016/bs.mcb.2018.07.004\">https://doi.org/10.1016/bs.mcb.2018.07.004</a>.","mla":"Renkawitz, Jörg, et al. “Micro-Engineered ‘Pillar Forests’ to Study Cell Migration in Complex but Controlled 3D Environments.” <i>Methods in Cell Biology</i>, vol. 147, Academic Press, 2018, pp. 79–91, doi:<a href=\"https://doi.org/10.1016/bs.mcb.2018.07.004\">10.1016/bs.mcb.2018.07.004</a>."},"page":"79 - 91","article_processing_charge":"No","oa_version":"None","_id":"153","abstract":[{"lang":"eng","text":"Cells migrating in multicellular organisms steadily traverse complex three-dimensional (3D) environments. To decipher the underlying cell biology, current experimental setups either use simplified 2D, tissue-mimetic 3D (e.g., collagen matrices) or in vivo environments. While only in vivo experiments are truly physiological, they do not allow for precise manipulation of environmental parameters. 2D in vitro experiments do allow mechanical and chemical manipulations, but increasing evidence demonstrates substantial differences of migratory mechanisms in 2D and 3D. Here, we describe simple, robust, and versatile “pillar forests” to investigate cell migration in complex but fully controllable 3D environments. Pillar forests are polydimethylsiloxane-based setups, in which two closely adjacent surfaces are interconnected by arrays of micrometer-sized pillars. Changing the pillar shape, size, height and the inter-pillar distance precisely manipulates microenvironmental parameters (e.g., pore sizes, micro-geometry, micro-topology), while being easily combined with chemotactic cues, surface coatings, diverse cell types and advanced imaging techniques. Thus, pillar forests combine the advantages of 2D cell migration assays with the precise definition of 3D environmental parameters."}],"doi":"10.1016/bs.mcb.2018.07.004","type":"book_chapter","publist_id":"7768","publication":"Methods in Cell Biology","day":"27","volume":147,"month":"07","language":[{"iso":"eng"}]}]