[{"page":"41002","date_created":"2018-12-11T11:50:04Z","article_processing_charge":"No","status":"public","publication":"Scientific Reports","title":"Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide","language":[{"iso":"eng"}],"file":[{"date_updated":"2018-12-12T10:14:59Z","creator":"system","content_type":"application/pdf","file_id":"5115","file_name":"IST-2017-790-v1+1_srep41002_1_.pdf","file_size":1994139,"access_level":"open_access","date_created":"2018-12-12T10:14:59Z","relation":"main_file"}],"external_id":{"isi":["000393163800001"]},"date_published":"2017-02-01T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 600-million-year-old oxytocin/vasopressin signalling system. We isolated the insect oxytocin/vasopressin orthologue inotocin from the black garden ant (Lasius niger), identified and cloned its cognate receptor and determined its pharmacological properties on the insect and human oxytocin/vasopressin receptors. Subsequently, we identified a functional dichotomy: inotocin activated the insect inotocin and the human vasopressin V1b receptors, but inhibited the human V1aR. Replacement of Arg8 of inotocin by D-Arg8 led to a potent, stable and competitive V1aR-antagonist ([D-Arg8]-inotocin) with a 3,000-fold binding selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R. The Arg8/D-Arg8 ligand-pair was further investigated to gain novel insights into the oxytocin/vasopressin peptide-receptor interaction, which led to the identification of key residues of the receptors that are important for ligand functionality and selectivity. These observations could play an important role for development of oxytocin/vasopressin receptor modulators that would enable clear distinction of the physiological and pathological responses of the individual receptor subtypes."}],"scopus_import":"1","publisher":"Nature Publishing Group","ddc":["570","590"],"publication_status":"published","file_date_updated":"2018-12-12T10:14:59Z","oa":1,"author":[{"last_name":"Di Giglio","full_name":"Di Giglio, Maria","first_name":"Maria"},{"last_name":"Muttenthaler","full_name":"Muttenthaler, Markus","first_name":"Markus"},{"first_name":"Kasper","full_name":"Harpsøe, Kasper","last_name":"Harpsøe"},{"full_name":"Liutkeviciute, Zita","last_name":"Liutkeviciute","first_name":"Zita"},{"first_name":"Peter","last_name":"Keov","full_name":"Keov, Peter"},{"first_name":"Thomas","last_name":"Eder","full_name":"Eder, Thomas"},{"last_name":"Rattei","full_name":"Rattei, Thomas","first_name":"Thomas"},{"full_name":"Arrowsmith, Sarah","last_name":"Arrowsmith","first_name":"Sarah"},{"first_name":"Susan","full_name":"Wray, Susan","last_name":"Wray"},{"first_name":"Ales","full_name":"Marek, Ales","last_name":"Marek"},{"full_name":"Elbert, Tomas","last_name":"Elbert","first_name":"Tomas"},{"last_name":"Alewood","full_name":"Alewood, Paul","first_name":"Paul"},{"first_name":"David","last_name":"Gloriam","full_name":"Gloriam, David"},{"full_name":"Gruber, Christian","last_name":"Gruber","first_name":"Christian"}],"has_accepted_license":"1","oa_version":"Published Version","quality_controlled":"1","doi":"10.1038/srep41002","pubrep_id":"790","volume":7,"month":"02","intvolume":"         7","publist_id":"6291","license":"https://creativecommons.org/licenses/by/4.0/","_id":"1086","year":"2017","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"mla":"Di Giglio, Maria, et al. “Development of a Human Vasopressin V1a-Receptor Antagonist from an Evolutionary-Related Insect Neuropeptide.” <i>Scientific Reports</i>, vol. 7, Nature Publishing Group, 2017, p. 41002, doi:<a href=\"https://doi.org/10.1038/srep41002\">10.1038/srep41002</a>.","apa":"Di Giglio, M., Muttenthaler, M., Harpsøe, K., Liutkeviciute, Z., Keov, P., Eder, T., … Gruber, C. (2017). Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. <i>Scientific Reports</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/srep41002\">https://doi.org/10.1038/srep41002</a>","short":"M. Di Giglio, M. Muttenthaler, K. Harpsøe, Z. Liutkeviciute, P. Keov, T. Eder, T. Rattei, S. Arrowsmith, S. Wray, A. Marek, T. Elbert, P. Alewood, D. Gloriam, C. Gruber, Scientific Reports 7 (2017) 41002.","ama":"Di Giglio M, Muttenthaler M, Harpsøe K, et al. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. <i>Scientific Reports</i>. 2017;7:41002. doi:<a href=\"https://doi.org/10.1038/srep41002\">10.1038/srep41002</a>","ieee":"M. Di Giglio <i>et al.</i>, “Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide,” <i>Scientific Reports</i>, vol. 7. Nature Publishing Group, p. 41002, 2017.","chicago":"Di Giglio, Maria, Markus Muttenthaler, Kasper Harpsøe, Zita Liutkeviciute, Peter Keov, Thomas Eder, Thomas Rattei, et al. “Development of a Human Vasopressin V1a-Receptor Antagonist from an Evolutionary-Related Insect Neuropeptide.” <i>Scientific Reports</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/srep41002\">https://doi.org/10.1038/srep41002</a>.","ista":"Di Giglio M, Muttenthaler M, Harpsøe K, Liutkeviciute Z, Keov P, Eder T, Rattei T, Arrowsmith S, Wray S, Marek A, Elbert T, Alewood P, Gloriam D, Gruber C. 2017. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Scientific Reports. 7, 41002."},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"isi":1,"day":"01","date_updated":"2023-09-20T11:47:47Z"},{"month":"02","volume":813,"doi":"10.1017/jfm.2017.14","oa_version":"Submitted Version","quality_controlled":"1","isi":1,"day":"25","date_updated":"2025-06-04T08:35:11Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Song, Baofang, et al. “Speed and Structure of Turbulent Fronts in Pipe Flow.” <i>Journal of Fluid Mechanics</i>, vol. 813, Cambridge University Press, 2017, pp. 1045–59, doi:<a href=\"https://doi.org/10.1017/jfm.2017.14\">10.1017/jfm.2017.14</a>.","apa":"Song, B., Barkley, D., Hof, B., &#38; Avila, M. (2017). Speed and structure of turbulent fronts in pipe flow. <i>Journal of Fluid Mechanics</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/jfm.2017.14\">https://doi.org/10.1017/jfm.2017.14</a>","short":"B. Song, D. Barkley, B. Hof, M. Avila, Journal of Fluid Mechanics 813 (2017) 1045–1059.","ama":"Song B, Barkley D, Hof B, Avila M. Speed and structure of turbulent fronts in pipe flow. <i>Journal of Fluid Mechanics</i>. 2017;813:1045-1059. doi:<a href=\"https://doi.org/10.1017/jfm.2017.14\">10.1017/jfm.2017.14</a>","ista":"Song B, Barkley D, Hof B, Avila M. 2017. Speed and structure of turbulent fronts in pipe flow. Journal of Fluid Mechanics. 813, 1045–1059.","ieee":"B. Song, D. Barkley, B. Hof, and M. Avila, “Speed and structure of turbulent fronts in pipe flow,” <i>Journal of Fluid Mechanics</i>, vol. 813. Cambridge University Press, pp. 1045–1059, 2017.","chicago":"Song, Baofang, Dwight Barkley, Björn Hof, and Marc Avila. “Speed and Structure of Turbulent Fronts in Pipe Flow.” <i>Journal of Fluid Mechanics</i>. Cambridge University Press, 2017. <a href=\"https://doi.org/10.1017/jfm.2017.14\">https://doi.org/10.1017/jfm.2017.14</a>."},"ec_funded":1,"year":"2017","_id":"1087","intvolume":"       813","publist_id":"6290","arxiv":1,"language":[{"iso":"eng"}],"title":"Speed and structure of turbulent fronts in pipe flow","publication":"Journal of Fluid Mechanics","date_created":"2018-12-11T11:50:04Z","article_processing_charge":"No","status":"public","page":"1045 - 1059","author":[{"first_name":"Baofang","last_name":"Song","full_name":"Song, Baofang"},{"first_name":"Dwight","full_name":"Barkley, Dwight","last_name":"Barkley"},{"full_name":"Hof, Björn","last_name":"Hof","orcid":"0000-0003-2057-2754","first_name":"Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Avila","full_name":"Avila, Marc","first_name":"Marc"}],"department":[{"_id":"BjHo"}],"publication_identifier":{"issn":["0022-1120"]},"publication_status":"published","oa":1,"acknowledged_ssus":[{"_id":"ScienComp"}],"type":"journal_article","date_published":"2017-02-25T00:00:00Z","abstract":[{"text":"Using extensive direct numerical simulations, the dynamics of laminar-turbulent fronts in pipe flow is investigated for Reynolds numbers between and 5500. We here investigate the physical distinction between the fronts of weak and strong slugs both by analysing the turbulent kinetic energy budget and by comparing the downstream front motion to the advection speed of bulk turbulent structures. Our study shows that weak downstream fronts travel slower than turbulent structures in the bulk and correspond to decaying turbulence at the front. At the downstream front speed becomes faster than the advection speed, marking the onset of strong fronts. In contrast to weak fronts, turbulent eddies are generated at strong fronts by feeding on the downstream laminar flow. Our study also suggests that temporal fluctuations of production and dissipation at the downstream laminar-turbulent front drive the dynamical switches between the two types of front observed up to.","lang":"eng"}],"scopus_import":"1","publisher":"Cambridge University Press","external_id":{"arxiv":["1603.04077"],"isi":["000394376400044"]},"main_file_link":[{"url":"https://arxiv.org/abs/1603.04077","open_access":"1"}],"project":[{"call_identifier":"FP7","_id":"25152F3A-B435-11E9-9278-68D0E5697425","name":"Decoding the complexity of turbulence at its origin","grant_number":"306589"}]},{"oa_version":"Submitted Version","quality_controlled":"1","doi":"10.1214/16-AOS1478","issue":"3","volume":45,"month":"06","year":"2017","intvolume":"        45","publist_id":"6288","_id":"1089","isi":1,"date_updated":"2025-06-04T08:35:37Z","day":"01","citation":{"apa":"Fallat, S., Lauritzen, S., Sadeghi, K., Uhler, C., Wermuth, N., &#38; Zwiernik, P. (2017). Total positivity in Markov structures. <i>Annals of Statistics</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/16-AOS1478\">https://doi.org/10.1214/16-AOS1478</a>","mla":"Fallat, Shaun, et al. “Total Positivity in Markov Structures.” <i>Annals of Statistics</i>, vol. 45, no. 3, Institute of Mathematical Statistics, 2017, pp. 1152–84, doi:<a href=\"https://doi.org/10.1214/16-AOS1478\">10.1214/16-AOS1478</a>.","ama":"Fallat S, Lauritzen S, Sadeghi K, Uhler C, Wermuth N, Zwiernik P. Total positivity in Markov structures. <i>Annals of Statistics</i>. 2017;45(3):1152-1184. doi:<a href=\"https://doi.org/10.1214/16-AOS1478\">10.1214/16-AOS1478</a>","ista":"Fallat S, Lauritzen S, Sadeghi K, Uhler C, Wermuth N, Zwiernik P. 2017. Total positivity in Markov structures. Annals of Statistics. 45(3), 1152–1184.","chicago":"Fallat, Shaun, Steffen Lauritzen, Kayvan Sadeghi, Caroline Uhler, Nanny Wermuth, and Piotr Zwiernik. “Total Positivity in Markov Structures.” <i>Annals of Statistics</i>. Institute of Mathematical Statistics, 2017. <a href=\"https://doi.org/10.1214/16-AOS1478\">https://doi.org/10.1214/16-AOS1478</a>.","ieee":"S. Fallat, S. Lauritzen, K. Sadeghi, C. Uhler, N. Wermuth, and P. Zwiernik, “Total positivity in Markov structures,” <i>Annals of Statistics</i>, vol. 45, no. 3. Institute of Mathematical Statistics, pp. 1152–1184, 2017.","short":"S. Fallat, S. Lauritzen, K. Sadeghi, C. Uhler, N. Wermuth, P. Zwiernik, Annals of Statistics 45 (2017) 1152–1184."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Annals of Statistics","title":"Total positivity in Markov structures","page":"1152 - 1184","article_processing_charge":"No","date_created":"2018-12-11T11:50:05Z","status":"public","language":[{"iso":"eng"}],"corr_author":"1","arxiv":1,"main_file_link":[{"url":"https://arxiv.org/abs/1510.01290","open_access":"1"}],"external_id":{"isi":["000404395900008"],"arxiv":["1510.01290"]},"project":[{"_id":"2530CA10-B435-11E9-9278-68D0E5697425","name":"Gaussian Graphical Models: Theory and Applications","grant_number":"Y 903-N35","call_identifier":"FWF"}],"publication_identifier":{"issn":["0090-5364"]},"publication_status":"published","department":[{"_id":"CaUh"}],"oa":1,"author":[{"full_name":"Fallat, Shaun","last_name":"Fallat","first_name":"Shaun"},{"last_name":"Lauritzen","full_name":"Lauritzen, Steffen","first_name":"Steffen"},{"full_name":"Sadeghi, Kayvan","last_name":"Sadeghi","first_name":"Kayvan"},{"id":"49ADD78E-F248-11E8-B48F-1D18A9856A87","first_name":"Caroline","full_name":"Uhler, Caroline","orcid":"0000-0002-7008-0216","last_name":"Uhler"},{"first_name":"Nanny","last_name":"Wermuth","full_name":"Wermuth, Nanny"},{"last_name":"Zwiernik","full_name":"Zwiernik, Piotr","first_name":"Piotr"}],"type":"journal_article","date_published":"2017-06-01T00:00:00Z","abstract":[{"lang":"eng","text":"We discuss properties of distributions that are multivariate totally positive of order two (MTP2) related to conditional independence. In particular, we show that any independence model generated by an MTP2 distribution is a compositional semigraphoid which is upward-stable and singleton-transitive. In addition, we prove that any MTP2 distribution satisfying an appropriate support condition is faithful to its concentration graph. Finally, we analyze factorization properties of MTP2 distributions and discuss ways of constructing MTP2 distributions; in particular we give conditions on the log-linear parameters of a discrete distribution which ensure MTP2 and characterize conditional Gaussian distributions which satisfy MTP2."}],"scopus_import":"1","publisher":"Institute of Mathematical Statistics"},{"_id":"1104","intvolume":"         8","publist_id":"6266","ec_funded":1,"year":"2017","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Deny, Stephane, et al. “Multiplexed Computations in Retinal Ganglion Cells of a Single Type.” <i>Nature Communications</i>, vol. 8, no. 1, 1964, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-02159-y\">10.1038/s41467-017-02159-y</a>.","apa":"Deny, S., Ferrari, U., Mace, E., Yger, P., Caplette, R., Picaud, S., … Marre, O. (2017). Multiplexed computations in retinal ganglion cells of a single type. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-017-02159-y\">https://doi.org/10.1038/s41467-017-02159-y</a>","short":"S. Deny, U. Ferrari, E. Mace, P. Yger, R. Caplette, S. Picaud, G. Tkačik, O. Marre, Nature Communications 8 (2017).","chicago":"Deny, Stephane, Ulisse Ferrari, Emilie Mace, Pierre Yger, Romain Caplette, Serge Picaud, Gašper Tkačik, and Olivier Marre. “Multiplexed Computations in Retinal Ganglion Cells of a Single Type.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/s41467-017-02159-y\">https://doi.org/10.1038/s41467-017-02159-y</a>.","ista":"Deny S, Ferrari U, Mace E, Yger P, Caplette R, Picaud S, Tkačik G, Marre O. 2017. Multiplexed computations in retinal ganglion cells of a single type. Nature Communications. 8(1), 1964.","ieee":"S. Deny <i>et al.</i>, “Multiplexed computations in retinal ganglion cells of a single type,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017.","ama":"Deny S, Ferrari U, Mace E, et al. Multiplexed computations in retinal ganglion cells of a single type. <i>Nature Communications</i>. 2017;8(1). doi:<a href=\"https://doi.org/10.1038/s41467-017-02159-y\">10.1038/s41467-017-02159-y</a>"},"isi":1,"day":"06","date_updated":"2025-07-10T11:50:05Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","issue":"1","doi":"10.1038/s41467-017-02159-y","oa_version":"Published Version","quality_controlled":"1","pubrep_id":"921","month":"12","volume":8,"project":[{"call_identifier":"FP7","_id":"25CD3DD2-B435-11E9-9278-68D0E5697425","name":"Localization of ion channels and receptors by two and three-dimensional immunoelectron microscopic approaches","grant_number":"604102"},{"call_identifier":"FWF","_id":"254D1A94-B435-11E9-9278-68D0E5697425","name":"Sensitivity to higher-order statistics in natural scenes","grant_number":"P 25651-N26"}],"article_number":"1964","external_id":{"isi":["000417241200004"]},"file":[{"date_created":"2018-12-12T10:16:06Z","relation":"main_file","file_id":"5191","file_name":"IST-2018-921-v1+1_s41467-017-02159-y.pdf","file_size":2872887,"access_level":"open_access","content_type":"application/pdf","date_updated":"2018-12-12T10:16:06Z","creator":"system"}],"ddc":["571"],"date_published":"2017-12-06T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"In the early visual system, cells of the same type perform the same computation in different places of the visual field. How these cells code together a complex visual scene is unclear. A common assumption is that cells of a single-type extract a single-stimulus feature to form a feature map, but this has rarely been observed directly. Using large-scale recordings in the rat retina, we show that a homogeneous population of fast OFF ganglion cells simultaneously encodes two radically different features of a visual scene. Cells close to a moving object code quasilinearly for its position, while distant cells remain largely invariant to the object's position and, instead, respond nonlinearly to changes in the object's speed. We develop a quantitative model that accounts for this effect and identify a disinhibitory circuit that mediates it. Ganglion cells of a single type thus do not code for one, but two features simultaneously. This richer, flexible neural map might also be present in other sensory systems."}],"publisher":"Nature Publishing Group","scopus_import":"1","author":[{"first_name":"Stephane","full_name":"Deny, Stephane","last_name":"Deny"},{"full_name":"Ferrari, Ulisse","last_name":"Ferrari","first_name":"Ulisse"},{"last_name":"Mace","full_name":"Mace, Emilie","first_name":"Emilie"},{"last_name":"Yger","full_name":"Yger, Pierre","first_name":"Pierre"},{"first_name":"Romain","full_name":"Caplette, Romain","last_name":"Caplette"},{"full_name":"Picaud, Serge","last_name":"Picaud","first_name":"Serge"},{"last_name":"Tkacik","orcid":"0000-0002-6699-1455","full_name":"Tkacik, Gasper","first_name":"Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Olivier","full_name":"Marre, Olivier","last_name":"Marre"}],"publication_status":"published","publication_identifier":{"issn":["2041-1723"]},"department":[{"_id":"GaTk"}],"file_date_updated":"2018-12-12T10:16:06Z","oa":1,"article_processing_charge":"No","date_created":"2018-12-11T11:50:10Z","status":"public","title":"Multiplexed computations in retinal ganglion cells of a single type","publication":"Nature Communications","language":[{"iso":"eng"}]},{"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry"],"day":"30","date_updated":"2024-10-14T11:20:12Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Buchwalter A, Hetzer M. Nucleolar expansion and elevated protein translation in premature aging. <i>Nature Communications</i>. 2017;8. doi:<a href=\"https://doi.org/10.1038/s41467-017-00322-z\">10.1038/s41467-017-00322-z</a>","ieee":"A. Buchwalter and M. Hetzer, “Nucleolar expansion and elevated protein translation in premature aging,” <i>Nature Communications</i>, vol. 8. Springer Nature, 2017.","ista":"Buchwalter A, Hetzer M. 2017. Nucleolar expansion and elevated protein translation in premature aging. Nature Communications. 8, 328.","chicago":"Buchwalter, Abigail, and Martin Hetzer. “Nucleolar Expansion and Elevated Protein Translation in Premature Aging.” <i>Nature Communications</i>. Springer Nature, 2017. <a href=\"https://doi.org/10.1038/s41467-017-00322-z\">https://doi.org/10.1038/s41467-017-00322-z</a>.","short":"A. Buchwalter, M. Hetzer, Nature Communications 8 (2017).","apa":"Buchwalter, A., &#38; Hetzer, M. (2017). Nucleolar expansion and elevated protein translation in premature aging. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-017-00322-z\">https://doi.org/10.1038/s41467-017-00322-z</a>","mla":"Buchwalter, Abigail, and Martin Hetzer. “Nucleolar Expansion and Elevated Protein Translation in Premature Aging.” <i>Nature Communications</i>, vol. 8, 328, Springer Nature, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-00322-z\">10.1038/s41467-017-00322-z</a>."},"year":"2017","article_type":"original","intvolume":"         8","_id":"11065","volume":8,"month":"08","oa_version":"Published Version","quality_controlled":"1","doi":"10.1038/s41467-017-00322-z","publication_identifier":{"issn":["2041-1723"]},"publication_status":"published","oa":1,"author":[{"first_name":"Abigail","last_name":"Buchwalter","full_name":"Buchwalter, Abigail"},{"orcid":"0000-0002-2111-992X","last_name":"HETZER","full_name":"HETZER, Martin W","first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"abstract":[{"text":"Premature aging disorders provide an opportunity to study the mechanisms that drive aging. In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We sought to investigate protein homeostasis in this disease. Here, we report a widespread increase in protein turnover in HGPS-derived cells compared to normal cells. We determine that global protein synthesis is elevated as a consequence of activated nucleoli and enhanced ribosome biogenesis in HGPS-derived fibroblasts. Depleting normal lamin A or inducing mutant lamin A expression are each sufficient to drive nucleolar expansion. We further show that nucleolar size correlates with donor age in primary fibroblasts derived from healthy individuals and that ribosomal RNA production increases with age, indicating that nucleolar size and activity can serve as aging biomarkers. While limiting ribosome biogenesis extends lifespan in several systems, we show that increased ribosome biogenesis and activity are a hallmark of premature aging.","lang":"eng"}],"date_published":"2017-08-30T00:00:00Z","type":"journal_article","publisher":"Springer Nature","scopus_import":"1","extern":"1","main_file_link":[{"url":"https://doi.org/10.1038/s41467-017-00322-z","open_access":"1"}],"external_id":{"pmid":["28855503"]},"article_number":"328","language":[{"iso":"eng"}],"publication":"Nature Communications","title":"Nucleolar expansion and elevated protein translation in premature aging","article_processing_charge":"No","date_created":"2022-04-07T07:45:50Z","status":"public","pmid":1},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/gad.306753.117"}],"external_id":{"pmid":["29269482"]},"publication_identifier":{"issn":["0890-9369","1549-5477"]},"publication_status":"published","oa":1,"author":[{"full_name":"Franks, Tobias M.","last_name":"Franks","first_name":"Tobias M."},{"full_name":"McCloskey, Asako","last_name":"McCloskey","first_name":"Asako"},{"first_name":"Maxim Nikolaievich","full_name":"Shokhirev, Maxim Nikolaievich","last_name":"Shokhirev"},{"last_name":"Benner","full_name":"Benner, Chris","first_name":"Chris"},{"first_name":"Annie","last_name":"Rathore","full_name":"Rathore, Annie"},{"first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","last_name":"HETZER","full_name":"HETZER, Martin W"}],"date_published":"2017-12-21T00:00:00Z","abstract":[{"text":"Recent studies have shown that a subset of nucleoporins (Nups) can detach from the nuclear pore complex and move into the nuclear interior to regulate transcription. One such dynamic Nup, called Nup98, has been implicated in gene activation in healthy cells and has been shown to drive leukemogenesis when mutated in patients with acute myeloid leukemia (AML). Here we show that in hematopoietic cells, Nup98 binds predominantly to transcription start sites to recruit the Wdr82–Set1A/COMPASS (complex of proteins associated with Set1) complex, which is required for deposition of the histone 3 Lys4 trimethyl (H3K4me3)-activating mark. Depletion of Nup98 or Wdr82 abolishes Set1A recruitment to chromatin and subsequently ablates H3K4me3 at adjacent promoters. Furthermore, expression of a Nup98 fusion protein implicated in aggressive AML causes mislocalization of H3K4me3 at abnormal regions and up-regulation of associated genes. Our findings establish a function of Nup98 in hematopoietic gene activation and provide mechanistic insight into which Nup98 leukemic fusion proteins promote AML.","lang":"eng"}],"type":"journal_article","extern":"1","scopus_import":"1","publisher":"Cold Spring Harbor Laboratory","publication":"Genes & Development","title":"Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells","page":"2222-2234","date_created":"2022-04-07T07:45:59Z","article_processing_charge":"No","status":"public","pmid":1,"language":[{"iso":"eng"}],"article_type":"original","year":"2017","intvolume":"        31","_id":"11066","keyword":["Developmental Biology","Genetics"],"date_updated":"2024-10-14T11:20:24Z","day":"21","citation":{"mla":"Franks, Tobias M., et al. “Nup98 Recruits the Wdr82–Set1A/COMPASS Complex to Promoters to Regulate H3K4 Trimethylation in Hematopoietic Progenitor Cells.” <i>Genes &#38; Development</i>, vol. 31, no. 22, Cold Spring Harbor Laboratory, 2017, pp. 2222–34, doi:<a href=\"https://doi.org/10.1101/gad.306753.117\">10.1101/gad.306753.117</a>.","apa":"Franks, T. M., McCloskey, A., Shokhirev, M. N., Benner, C., Rathore, A., &#38; Hetzer, M. (2017). Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory. <a href=\"https://doi.org/10.1101/gad.306753.117\">https://doi.org/10.1101/gad.306753.117</a>","short":"T.M. Franks, A. McCloskey, M.N. Shokhirev, C. Benner, A. Rathore, M. Hetzer, Genes &#38; Development 31 (2017) 2222–2234.","ista":"Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. 2017. Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes &#38; Development. 31(22), 2222–2234.","chicago":"Franks, Tobias M., Asako McCloskey, Maxim Nikolaievich Shokhirev, Chris Benner, Annie Rathore, and Martin Hetzer. “Nup98 Recruits the Wdr82–Set1A/COMPASS Complex to Promoters to Regulate H3K4 Trimethylation in Hematopoietic Progenitor Cells.” <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory, 2017. <a href=\"https://doi.org/10.1101/gad.306753.117\">https://doi.org/10.1101/gad.306753.117</a>.","ieee":"T. M. Franks, A. McCloskey, M. N. Shokhirev, C. Benner, A. Rathore, and M. Hetzer, “Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells,” <i>Genes &#38; Development</i>, vol. 31, no. 22. Cold Spring Harbor Laboratory, pp. 2222–2234, 2017.","ama":"Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. <i>Genes &#38; Development</i>. 2017;31(22):2222-2234. doi:<a href=\"https://doi.org/10.1101/gad.306753.117\">10.1101/gad.306753.117</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","quality_controlled":"1","doi":"10.1101/gad.306753.117","issue":"22","volume":31,"month":"12"},{"_id":"11067","intvolume":"        21","article_type":"original","year":"2017","citation":{"short":"T. Toda, J.Y. Hsu, S.B. Linker, L. Hu, S.T. Schafer, J. Mertens, F.V. Jacinto, M. Hetzer, F.H. Gage, Cell Stem Cell 21 (2017) 618–634.e7.","ieee":"T. Toda <i>et al.</i>, “Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells,” <i>Cell Stem Cell</i>, vol. 21, no. 5. Elsevier, p. 618–634.e7, 2017.","ista":"Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer M, Gage FH. 2017. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. Cell Stem Cell. 21(5), 618–634.e7.","chicago":"Toda, Tomohisa, Jonathan Y. Hsu, Sara B. Linker, Lauren Hu, Simon T. Schafer, Jerome Mertens, Filipe V. Jacinto, Martin Hetzer, and Fred H. Gage. “Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.” <i>Cell Stem Cell</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">https://doi.org/10.1016/j.stem.2017.08.012</a>.","ama":"Toda T, Hsu JY, Linker SB, et al. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. <i>Cell Stem Cell</i>. 2017;21(5):618-634.e7. doi:<a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">10.1016/j.stem.2017.08.012</a>","mla":"Toda, Tomohisa, et al. “Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.” <i>Cell Stem Cell</i>, vol. 21, no. 5, Elsevier, 2017, p. 618–634.e7, doi:<a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">10.1016/j.stem.2017.08.012</a>.","apa":"Toda, T., Hsu, J. Y., Linker, S. B., Hu, L., Schafer, S. T., Mertens, J., … Gage, F. H. (2017). Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. <i>Cell Stem Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">https://doi.org/10.1016/j.stem.2017.08.012</a>"},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","keyword":["Cell Biology","Genetics","Molecular Medicine"],"day":"02","date_updated":"2022-07-18T08:33:07Z","issue":"5","doi":"10.1016/j.stem.2017.08.012","oa_version":"Published Version","quality_controlled":"1","month":"11","volume":21,"external_id":{"pmid":["28919367"]},"main_file_link":[{"url":"https://doi.org/10.1016/j.stem.2017.08.012","open_access":"1"}],"abstract":[{"text":"Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors is unclear. Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neuronal differentiation. Genome-wide analyses show that Nup153 and Sox2 bind and co-regulate hundreds of genes. Binding of Nup153 to gene promoters or transcriptional end sites correlates with increased or decreased gene expression, respectively, and inhibiting Nup153 expression alters open chromatin configurations at its target genes, disrupts genomic localization of Sox2, and promotes differentiation in vitro and a gliogenic fate switch in vivo. Together, these findings reveal that nuclear structural proteins may exert bimodal transcriptional effects to control cell fate.","lang":"eng"}],"type":"journal_article","date_published":"2017-11-02T00:00:00Z","scopus_import":"1","publisher":"Elsevier","extern":"1","author":[{"full_name":"Toda, Tomohisa","last_name":"Toda","first_name":"Tomohisa"},{"first_name":"Jonathan Y.","last_name":"Hsu","full_name":"Hsu, Jonathan Y."},{"first_name":"Sara B.","full_name":"Linker, Sara B.","last_name":"Linker"},{"full_name":"Hu, Lauren","last_name":"Hu","first_name":"Lauren"},{"first_name":"Simon T.","last_name":"Schafer","full_name":"Schafer, Simon T."},{"full_name":"Mertens, Jerome","last_name":"Mertens","first_name":"Jerome"},{"first_name":"Filipe V.","last_name":"Jacinto","full_name":"Jacinto, Filipe V."},{"full_name":"HETZER, Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W"},{"last_name":"Gage","full_name":"Gage, Fred H.","first_name":"Fred H."}],"publication_identifier":{"issn":["1934-5909"]},"publication_status":"published","oa":1,"article_processing_charge":"No","date_created":"2022-04-07T07:46:12Z","status":"public","pmid":1,"page":"618-634.e7","title":"Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells","publication":"Cell Stem Cell","language":[{"iso":"eng"}]},{"doi":"10.1016/j.bbr.2017.01.029","oa_version":"Published Version","quality_controlled":"1","has_accepted_license":"1","month":"04","volume":323,"acknowledgement":"Austrian Science Fund (FWF) for funding this research [I914,P21092]","pubrep_id":"868","year":"2017","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","_id":"1107","intvolume":"       323","publist_id":"6262","isi":1,"date_updated":"2023-09-20T11:37:25Z","day":"14","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"mla":"Breuss, Martin, et al. “Brain Specific Knockin of the Pathogenic Tubb5 E401K Allele Causes Defects in Motor Coordination and Prepulse Inhibition.” <i>Behavioural Brain Research</i>, vol. 323, Elsevier, 2017, pp. 47–55, doi:<a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">10.1016/j.bbr.2017.01.029</a>.","apa":"Breuss, M., Hansen, A. H., Landler, L., &#38; Keays, D. (2017). Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. <i>Behavioural Brain Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">https://doi.org/10.1016/j.bbr.2017.01.029</a>","short":"M. Breuss, A.H. Hansen, L. Landler, D. Keays, Behavioural Brain Research 323 (2017) 47–55.","ista":"Breuss M, Hansen AH, Landler L, Keays D. 2017. Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. Behavioural Brain Research. 323, 47–55.","chicago":"Breuss, Martin, Andi H Hansen, Lukas Landler, and David Keays. “Brain Specific Knockin of the Pathogenic Tubb5 E401K Allele Causes Defects in Motor Coordination and Prepulse Inhibition.” <i>Behavioural Brain Research</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">https://doi.org/10.1016/j.bbr.2017.01.029</a>.","ama":"Breuss M, Hansen AH, Landler L, Keays D. Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. <i>Behavioural Brain Research</i>. 2017;323:47-55. doi:<a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">10.1016/j.bbr.2017.01.029</a>","ieee":"M. Breuss, A. H. Hansen, L. Landler, and D. Keays, “Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition,” <i>Behavioural Brain Research</i>, vol. 323. Elsevier, pp. 47–55, 2017."},"title":"Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition","publication":"Behavioural Brain Research","date_created":"2018-12-11T11:50:11Z","article_processing_charge":"No","status":"public","page":"47 - 55","language":[{"iso":"eng"}],"external_id":{"isi":["000397369100007"]},"file":[{"date_created":"2018-12-12T10:12:03Z","relation":"main_file","access_level":"open_access","file_size":2291511,"file_name":"IST-2017-868-v1+1_1-s2.0-S0166432816309160-main.pdf","file_id":"4921","content_type":"application/pdf","date_updated":"2018-12-12T10:12:03Z","creator":"system"}],"author":[{"first_name":"Martin","full_name":"Breuss, Martin","last_name":"Breuss"},{"full_name":"Hansen, Andi H","last_name":"Hansen","id":"38853E16-F248-11E8-B48F-1D18A9856A87","first_name":"Andi H"},{"first_name":"Lukas","last_name":"Landler","full_name":"Landler, Lukas"},{"last_name":"Keays","full_name":"Keays, David","first_name":"David"}],"publication_status":"published","publication_identifier":{"issn":["01664328"]},"oa":1,"file_date_updated":"2018-12-12T10:12:03Z","ddc":["570","571"],"type":"journal_article","date_published":"2017-04-14T00:00:00Z","abstract":[{"text":"The generation, migration, and differentiation of neurons requires the functional integrity of the microtubule cytoskeleton. Mutations in the tubulin gene family are known to cause various neurological diseases including lissencephaly, ocular motor disorders, polymicrogyria and amyotrophic lateral sclerosis. We have previously reported that mutations in TUBB5 cause microcephaly that is accompanied by severe intellectual impairment and motor delay. Here we present the characterization of a Tubb5 mouse model that allows for the conditional expression of the pathogenic E401K mutation. Homozygous knockin animals exhibit a severe reduction in brain size and in body weight. These animals do not show any significant impairment in general activity, anxiety, or in the acoustic startle response, however, present with notable defects in motor coordination. When assessed on the static rod apparatus mice took longer to orient and often lost their balance completely. Interestingly, mutant animals also showed defects in prepulse inhibition, a phenotype associated with sensorimotor gating and considered an endophenotype for schizophrenia. This study provides insight into the behavioral consequences of tubulin gene mutations.","lang":"eng"}],"publisher":"Elsevier","extern":"1"},{"_id":"1108","intvolume":"        54","publist_id":"6261","ec_funded":1,"year":"2017","citation":{"apa":"Zimin, A., &#38; Lampert, C. (2017). Learning theory for conditional risk minimization (Vol. 54, pp. 213–222). Presented at the AISTATS: Artificial Intelligence and Statistics, Fort Lauderdale, FL, United States: ML Research Press.","mla":"Zimin, Alexander, and Christoph Lampert. <i>Learning Theory for Conditional Risk Minimization</i>. Vol. 54, ML Research Press, 2017, pp. 213–22.","ista":"Zimin A, Lampert C. 2017. Learning theory for conditional risk minimization. AISTATS: Artificial Intelligence and Statistics, PMLR, vol. 54, 213–222.","chicago":"Zimin, Alexander, and Christoph Lampert. “Learning Theory for Conditional Risk Minimization,” 54:213–22. ML Research Press, 2017.","ieee":"A. Zimin and C. Lampert, “Learning theory for conditional risk minimization,” presented at the AISTATS: Artificial Intelligence and Statistics, Fort Lauderdale, FL, United States, 2017, vol. 54, pp. 213–222.","ama":"Zimin A, Lampert C. Learning theory for conditional risk minimization. In: Vol 54. ML Research Press; 2017:213-222.","short":"A. Zimin, C. Lampert, in:, ML Research Press, 2017, pp. 213–222."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","isi":1,"day":"01","date_updated":"2025-04-15T07:10:22Z","oa_version":"Submitted Version","quality_controlled":"1","month":"04","volume":54,"project":[{"call_identifier":"FP7","_id":"2532554C-B435-11E9-9278-68D0E5697425","name":"Lifelong Learning of Visual Scene Understanding","grant_number":"308036"}],"external_id":{"isi":["000509368500024"]},"main_file_link":[{"url":"http://proceedings.mlr.press/v54/zimin17a/zimin17a.pdf","open_access":"1"}],"type":"conference","abstract":[{"lang":"eng","text":"In this work we study the learnability of stochastic processes with respect to the conditional risk, i.e. the existence of a learning algorithm that improves its next-step performance with the amount of observed data. We introduce a notion of pairwise discrepancy between conditional distributions at different times steps and show how certain properties of these discrepancies can be used to construct a successful learning algorithm. Our main results are two theorems that establish criteria for learnability for many classes of stochastic processes, including all special cases studied previously in the literature."}],"date_published":"2017-04-01T00:00:00Z","publisher":"ML Research Press","author":[{"first_name":"Alexander","id":"37099E9C-F248-11E8-B48F-1D18A9856A87","last_name":"Zimin","full_name":"Zimin, Alexander"},{"first_name":"Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","last_name":"Lampert","orcid":"0000-0001-8622-7887","full_name":"Lampert, Christoph"}],"publication_status":"published","department":[{"_id":"ChLa"}],"oa":1,"date_created":"2018-12-11T11:50:11Z","article_processing_charge":"No","status":"public","page":"213 - 222","title":"Learning theory for conditional risk minimization","alternative_title":["PMLR"],"conference":{"name":"AISTATS: Artificial Intelligence and Statistics","end_date":"2017-04-22","start_date":"2017-04-20","location":"Fort Lauderdale, FL, United States"},"language":[{"iso":"eng"}]},{"main_file_link":[{"url":"https://arxiv.org/abs/1702.01977","open_access":"1"}],"external_id":{"arxiv":["1702.01977"],"isi":["000401664000005"]},"article_number":"203203","project":[{"call_identifier":"FWF","name":"Quantum rotations in the presence of a many-body environment","_id":"26031614-B435-11E9-9278-68D0E5697425","grant_number":"P29902"}],"publication_status":"published","department":[{"_id":"MiLe"}],"oa":1,"author":[{"full_name":"Shepperson, Benjamin","last_name":"Shepperson","first_name":"Benjamin"},{"first_name":"Anders","last_name":"Søndergaard","full_name":"Søndergaard, Anders"},{"last_name":"Christiansen","full_name":"Christiansen, Lars","first_name":"Lars"},{"full_name":"Kaczmarczyk, Jan","last_name":"Kaczmarczyk","orcid":"0000-0002-1629-3675","first_name":"Jan","id":"46C405DE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Zillich","full_name":"Zillich, Robert","first_name":"Robert"},{"last_name":"Lemeshko","orcid":"0000-0002-6990-7802","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail"},{"first_name":"Henrik","last_name":"Stapelfeldt","full_name":"Stapelfeldt, Henrik"}],"type":"journal_article","abstract":[{"lang":"eng","text":"Rotation of molecules embedded in He nanodroplets is explored by a combination of fs laser-induced alignment experiments and angulon quasiparticle theory. We demonstrate that at low fluence of the fs alignment pulse, the molecule and its solvation shell can be set into coherent collective rotation lasting long enough to form revivals. With increasing fluence, however, the revivals disappear -- instead, rotational dynamics as rapid as for an isolated molecule is observed during the first few picoseconds. Classical calculations trace this phenomenon to transient decoupling of the molecule from its He shell. Our results open novel opportunities for studying non-equilibrium solute-solvent dynamics and quantum thermalization. "}],"date_published":"2017-05-19T00:00:00Z","publisher":"American Physical Society","scopus_import":"1","publication":"Physical Review Letters","title":"Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free","date_created":"2018-12-11T11:50:12Z","article_processing_charge":"No","status":"public","language":[{"iso":"eng"}],"arxiv":1,"year":"2017","intvolume":"       118","publist_id":"6260","_id":"1109","isi":1,"day":"19","date_updated":"2025-06-04T08:36:27Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Shepperson B, Søndergaard A, Christiansen L, Kaczmarczyk J, Zillich R, Lemeshko M, Stapelfeldt H. 2017. Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free. Physical Review Letters. 118(20), 203203.","chicago":"Shepperson, Benjamin, Anders Søndergaard, Lars Christiansen, Jan Kaczmarczyk, Robert Zillich, Mikhail Lemeshko, and Henrik Stapelfeldt. “Laser-Induced Rotation of Iodine Molecules in Helium Nanodroplets: Revivals and Breaking-Free.” <i>Physical Review Letters</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevLett.118.203203\">https://doi.org/10.1103/PhysRevLett.118.203203</a>.","ama":"Shepperson B, Søndergaard A, Christiansen L, et al. Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free. <i>Physical Review Letters</i>. 2017;118(20). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.203203\">10.1103/PhysRevLett.118.203203</a>","ieee":"B. Shepperson <i>et al.</i>, “Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free,” <i>Physical Review Letters</i>, vol. 118, no. 20. American Physical Society, 2017.","short":"B. Shepperson, A. Søndergaard, L. Christiansen, J. Kaczmarczyk, R. Zillich, M. Lemeshko, H. Stapelfeldt, Physical Review Letters 118 (2017).","apa":"Shepperson, B., Søndergaard, A., Christiansen, L., Kaczmarczyk, J., Zillich, R., Lemeshko, M., &#38; Stapelfeldt, H. (2017). Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.118.203203\">https://doi.org/10.1103/PhysRevLett.118.203203</a>","mla":"Shepperson, Benjamin, et al. “Laser-Induced Rotation of Iodine Molecules in Helium Nanodroplets: Revivals and Breaking-Free.” <i>Physical Review Letters</i>, vol. 118, no. 20, 203203, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.203203\">10.1103/PhysRevLett.118.203203</a>."},"oa_version":"Preprint","quality_controlled":"1","doi":"10.1103/PhysRevLett.118.203203","issue":"20","volume":118,"month":"05"},{"publication":"Scientific Reports","title":"Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity","status":"public","date_created":"2018-12-11T11:50:12Z","article_processing_charge":"No","language":[{"iso":"eng"}],"file":[{"access_level":"open_access","file_size":1654496,"file_id":"5328","file_name":"IST-2017-803-v1+1_srep41906.pdf","date_created":"2018-12-12T10:18:09Z","relation":"main_file","date_updated":"2018-12-12T10:18:09Z","creator":"system","content_type":"application/pdf"}],"article_number":"41906","external_id":{"isi":["000393367600001"]},"project":[{"call_identifier":"FP7","grant_number":"282300","_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants"}],"file_date_updated":"2018-12-12T10:18:09Z","oa":1,"publication_identifier":{"issn":["2045-2322"]},"department":[{"_id":"JiFr"}],"publication_status":"published","author":[{"full_name":"Kuhn, Benjamin","last_name":"Kuhn","first_name":"Benjamin"},{"full_name":"Nodzyński, Tomasz","last_name":"Nodzyński","first_name":"Tomasz"},{"first_name":"Sanae","last_name":"Errafi","full_name":"Errafi, Sanae"},{"first_name":"Rahel","full_name":"Bucher, Rahel","last_name":"Bucher"},{"full_name":"Gupta, Shibu","last_name":"Gupta","first_name":"Shibu"},{"first_name":"Bibek","full_name":"Aryal, Bibek","last_name":"Aryal"},{"full_name":"Dobrev, Petre","last_name":"Dobrev","first_name":"Petre"},{"last_name":"Bigler","full_name":"Bigler, Laurent","first_name":"Laurent"},{"first_name":"Markus","last_name":"Geisler","full_name":"Geisler, Markus"},{"last_name":"Zažímalová","full_name":"Zažímalová, Eva","first_name":"Eva"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml"},{"first_name":"Christoph","full_name":"Ringli, Christoph","last_name":"Ringli"}],"publisher":"Nature Publishing Group","scopus_import":"1","abstract":[{"lang":"eng","text":"The phytohormone auxin is a major determinant and regulatory component important for plant development. Auxin transport between cells is mediated by a complex system of transporters such as AUX1/LAX, PIN, and ABCB proteins, and their localization and activity is thought to be influenced by phosphatases and kinases. Flavonols have been shown to alter auxin transport activity and changes in flavonol accumulation in the Arabidopsis thaliana rol1-2 mutant cause defects in auxin transport and seedling development. A new mutation in ROOTS CURL IN NPA 1 (RCN1), encoding a regulatory subunit of the phosphatase PP2A, was found to suppress the growth defects of rol1-2 without changing the flavonol content. rol1-2 rcn1-3 double mutants show wild type-like auxin transport activity while levels of free auxin are not affected by rcn1-3. In the rol1-2 mutant, PIN2 shows a flavonol-induced basal-to-apical shift in polar localization which is reversed in the rol1-2 rcn1-3 to basal localization. In vivo analysis of PINOID action, a kinase known to influence PIN protein localization in a PP2A-antagonistic manner, revealed a negative impact of flavonols on PINOID activity. Together, these data suggest that flavonols affect auxin transport by modifying the antagonistic kinase/phosphatase equilibrium."}],"type":"journal_article","date_published":"2017-02-06T00:00:00Z","ddc":["581"],"quality_controlled":"1","oa_version":"Published Version","doi":"10.1038/srep41906","has_accepted_license":"1","volume":7,"month":"02","acknowledgement":"European Research Council (project ERC-2011-StG-20101109-PSDP), European Social Fund (CZ.1.07/2.3.00/20.0043) and the Czech Science Foundation (GA13-40637S) [JF].","pubrep_id":"803","year":"2017","ec_funded":1,"publist_id":"6258","intvolume":"         7","_id":"1110","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_updated":"2025-07-10T11:50:06Z","day":"06","isi":1,"citation":{"mla":"Kuhn, Benjamin, et al. “Flavonol-Induced Changes in PIN2 Polarity and Auxin Transport in the Arabidopsis Thaliana Rol1-2 Mutant Require Phosphatase Activity.” <i>Scientific Reports</i>, vol. 7, 41906, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/srep41906\">10.1038/srep41906</a>.","apa":"Kuhn, B., Nodzyński, T., Errafi, S., Bucher, R., Gupta, S., Aryal, B., … Ringli, C. (2017). Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity. <i>Scientific Reports</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/srep41906\">https://doi.org/10.1038/srep41906</a>","short":"B. Kuhn, T. Nodzyński, S. Errafi, R. Bucher, S. Gupta, B. Aryal, P. Dobrev, L. Bigler, M. Geisler, E. Zažímalová, J. Friml, C. Ringli, Scientific Reports 7 (2017).","chicago":"Kuhn, Benjamin, Tomasz Nodzyński, Sanae Errafi, Rahel Bucher, Shibu Gupta, Bibek Aryal, Petre Dobrev, et al. “Flavonol-Induced Changes in PIN2 Polarity and Auxin Transport in the Arabidopsis Thaliana Rol1-2 Mutant Require Phosphatase Activity.” <i>Scientific Reports</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/srep41906\">https://doi.org/10.1038/srep41906</a>.","ieee":"B. Kuhn <i>et al.</i>, “Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity,” <i>Scientific Reports</i>, vol. 7. Nature Publishing Group, 2017.","ama":"Kuhn B, Nodzyński T, Errafi S, et al. Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity. <i>Scientific Reports</i>. 2017;7. doi:<a href=\"https://doi.org/10.1038/srep41906\">10.1038/srep41906</a>","ista":"Kuhn B, Nodzyński T, Errafi S, Bucher R, Gupta S, Aryal B, Dobrev P, Bigler L, Geisler M, Zažímalová E, Friml J, Ringli C. 2017. Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity. Scientific Reports. 7, 41906."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"volume":205,"month":"02","issue":"2","oa_version":"Published Version","quality_controlled":"1","doi":"10.1534/genetics.116.189340","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Heredia, Jorge, Barbora Trubenova, Dirk Sudholt, and Tiago Paixao. “Selection Limits to Adaptive Walks on Correlated Landscapes.” <i>Genetics</i>. Genetics Society of America, 2017. <a href=\"https://doi.org/10.1534/genetics.116.189340\">https://doi.org/10.1534/genetics.116.189340</a>.","ieee":"J. Heredia, B. Trubenova, D. Sudholt, and T. Paixao, “Selection limits to adaptive walks on correlated landscapes,” <i>Genetics</i>, vol. 205, no. 2. Genetics Society of America, pp. 803–825, 2017.","ama":"Heredia J, Trubenova B, Sudholt D, Paixao T. Selection limits to adaptive walks on correlated landscapes. <i>Genetics</i>. 2017;205(2):803-825. doi:<a href=\"https://doi.org/10.1534/genetics.116.189340\">10.1534/genetics.116.189340</a>","ista":"Heredia J, Trubenova B, Sudholt D, Paixao T. 2017. Selection limits to adaptive walks on correlated landscapes. Genetics. 205(2), 803–825.","short":"J. Heredia, B. Trubenova, D. Sudholt, T. Paixao, Genetics 205 (2017) 803–825.","apa":"Heredia, J., Trubenova, B., Sudholt, D., &#38; Paixao, T. (2017). Selection limits to adaptive walks on correlated landscapes. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.116.189340\">https://doi.org/10.1534/genetics.116.189340</a>","mla":"Heredia, Jorge, et al. “Selection Limits to Adaptive Walks on Correlated Landscapes.” <i>Genetics</i>, vol. 205, no. 2, Genetics Society of America, 2017, pp. 803–25, doi:<a href=\"https://doi.org/10.1534/genetics.116.189340\">10.1534/genetics.116.189340</a>."},"isi":1,"date_updated":"2025-07-10T11:50:06Z","day":"01","intvolume":"       205","publist_id":"6256","_id":"1111","ec_funded":1,"article_type":"original","year":"2017","language":[{"iso":"eng"}],"page":"803 - 825","date_created":"2018-12-11T11:50:12Z","article_processing_charge":"No","status":"public","pmid":1,"publication":"Genetics","title":"Selection limits to adaptive walks on correlated landscapes","date_published":"2017-02-01T00:00:00Z","abstract":[{"lang":"eng","text":"Adaptation depends critically on the effects of new mutations and their dependency on the genetic background in which they occur. These two factors can be summarized by the fitness landscape. However, it would require testing all mutations in all backgrounds, making the definition and analysis of fitness landscapes mostly inaccessible. Instead of postulating a particular fitness landscape, we address this problem by considering general classes of landscapes and calculating an upper limit for the time it takes for a population to reach a fitness peak, circumventing the need to have full knowledge about the fitness landscape. We analyze populations in the weak-mutation regime and characterize the conditions that enable them to quickly reach the fitness peak as a function of the number of sites under selection. We show that for additive landscapes there is a critical selection strength enabling populations to reach high-fitness genotypes, regardless of the distribution of effects. This threshold scales with the number of sites under selection, effectively setting a limit to adaptation, and results from the inevitable increase in deleterious mutational pressure as the population adapts in a space of discrete genotypes. Furthermore, we show that for the class of all unimodal landscapes this condition is sufficient but not necessary for rapid adaptation, as in some highly epistatic landscapes the critical strength does not depend on the number of sites under selection; effectively removing this barrier to adaptation."}],"type":"journal_article","publisher":"Genetics Society of America","scopus_import":"1","department":[{"_id":"NiBa"}],"publication_identifier":{"issn":["0016-6731"]},"publication_status":"published","oa":1,"author":[{"first_name":"Jorge","full_name":"Heredia, Jorge","last_name":"Heredia"},{"last_name":"Trubenova","orcid":"0000-0002-6873-2967","full_name":"Trubenova, Barbora","id":"42302D54-F248-11E8-B48F-1D18A9856A87","first_name":"Barbora"},{"first_name":"Dirk","last_name":"Sudholt","full_name":"Sudholt, Dirk"},{"first_name":"Tiago","id":"2C5658E6-F248-11E8-B48F-1D18A9856A87","full_name":"Paixao, Tiago","orcid":"0000-0003-2361-3953","last_name":"Paixao"}],"project":[{"call_identifier":"FP7","grant_number":"618091","_id":"25B1EC9E-B435-11E9-9278-68D0E5697425","name":"Speed of Adaptation in Population Genetics and Evolutionary Computation"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1534/genetics.116.189340"}],"external_id":{"pmid":["27881471"],"isi":["000394144900025"]}},{"year":"2017","publist_id":"6255","_id":"1112","publication_status":"published","department":[{"_id":"NiBa"}],"publication_identifier":{"isbn":["978-145034651-1"]},"day":"12","date_updated":"2021-01-12T06:48:22Z","author":[{"id":"2C5658E6-F248-11E8-B48F-1D18A9856A87","first_name":"Tiago","full_name":"Paixao, Tiago","last_name":"Paixao","orcid":"0000-0003-2361-3953"},{"first_name":"Jorge","full_name":"Pérez Heredia, Jorge","last_name":"Pérez Heredia"}],"scopus_import":1,"citation":{"ieee":"T. Paixao and J. Pérez Heredia, “An application of stochastic differential equations to evolutionary algorithms,” in <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i>, Copenhagen, Denmark, 2017, pp. 3–11.","ista":"Paixao T, Pérez Heredia J. 2017. An application of stochastic differential equations to evolutionary algorithms. Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms. FOGA: Foundations of Genetic Algorithms, 3–11.","ama":"Paixao T, Pérez Heredia J. An application of stochastic differential equations to evolutionary algorithms. In: <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i>. ACM; 2017:3-11. doi:<a href=\"https://doi.org/10.1145/3040718.3040729\">10.1145/3040718.3040729</a>","chicago":"Paixao, Tiago, and Jorge Pérez Heredia. “An Application of Stochastic Differential Equations to Evolutionary Algorithms.” In <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i>, 3–11. ACM, 2017. <a href=\"https://doi.org/10.1145/3040718.3040729\">https://doi.org/10.1145/3040718.3040729</a>.","short":"T. Paixao, J. Pérez Heredia, in:, Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms, ACM, 2017, pp. 3–11.","apa":"Paixao, T., &#38; Pérez Heredia, J. (2017). An application of stochastic differential equations to evolutionary algorithms. In <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i> (pp. 3–11). Copenhagen, Denmark: ACM. <a href=\"https://doi.org/10.1145/3040718.3040729\">https://doi.org/10.1145/3040718.3040729</a>","mla":"Paixao, Tiago, and Jorge Pérez Heredia. “An Application of Stochastic Differential Equations to Evolutionary Algorithms.” <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i>, ACM, 2017, pp. 3–11, doi:<a href=\"https://doi.org/10.1145/3040718.3040729\">10.1145/3040718.3040729</a>."},"publisher":"ACM","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2017-01-12T00:00:00Z","abstract":[{"lang":"eng","text":"There has been renewed interest in modelling the behaviour of evolutionary algorithms by more traditional mathematical objects, such as ordinary differential equations or Markov chains. The advantage is that the analysis becomes greatly facilitated due to the existence of well established methods. However, this typically comes at the cost of disregarding information about the process. Here, we introduce the use of stochastic differential equations (SDEs) for the study of EAs. SDEs can produce simple analytical results for the dynamics of stochastic processes, unlike Markov chains which can produce rigorous but unwieldy expressions about the dynamics. On the other hand, unlike ordinary differential equations (ODEs), they do not discard information about the stochasticity of the process. We show that these are especially suitable for the analysis of fixed budget scenarios and present analogs of the additive and multiplicative drift theorems for SDEs. We exemplify the use of these methods for two model algorithms ((1+1) EA and RLS) on two canonical problems(OneMax and LeadingOnes)."}],"type":"conference","quality_controlled":"1","publication":"Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms","oa_version":"None","title":"An application of stochastic differential equations to evolutionary algorithms","doi":"10.1145/3040718.3040729","page":"3 - 11","status":"public","date_created":"2018-12-11T11:50:12Z","month":"01","language":[{"iso":"eng"}],"conference":{"name":"FOGA: Foundations of Genetic Algorithms","end_date":"2017-01-15","start_date":"2017-01-12","location":"Copenhagen, Denmark"}},{"arxiv":1,"language":[{"iso":"eng"}],"title":"Hanani-Tutte for radial planarity","publication":"Journal of Graph Algorithms and Applications","status":"public","article_processing_charge":"No","date_created":"2018-12-11T11:50:13Z","page":"135 - 154","author":[{"first_name":"Radoslav","id":"39F3FFE4-F248-11E8-B48F-1D18A9856A87","last_name":"Fulek","orcid":"0000-0001-8485-1774","full_name":"Fulek, Radoslav"},{"first_name":"Michael","full_name":"Pelsmajer, Michael","last_name":"Pelsmajer"},{"full_name":"Schaefer, Marcus","last_name":"Schaefer","first_name":"Marcus"}],"file_date_updated":"2019-10-24T10:54:37Z","related_material":{"record":[{"status":"public","relation":"earlier_version","id":"1164"},{"relation":"earlier_version","status":"public","id":"1595"}]},"oa":1,"department":[{"_id":"UlWa"}],"publication_status":"published","ddc":["510"],"scopus_import":"1","publisher":"Brown University","date_published":"2017-01-01T00:00:00Z","abstract":[{"text":"A drawing of a graph G is radial if the vertices of G are placed on concentric circles C 1 , . . . , C k with common center c , and edges are drawn radially : every edge intersects every circle centered at c at most once. G is radial planar if it has a radial embedding, that is, a crossing-free radial drawing. If the vertices of G are ordered or partitioned into ordered levels (as they are for leveled graphs), we require that the assignment of vertices to circles corresponds to the given ordering or leveling. We show that a graph G is radial planar if G has a radial drawing in which every two edges cross an even number of times; the radial embedding has the same leveling as the radial drawing. In other words, we establish the weak variant of the Hanani-Tutte theorem for radial planarity. This generalizes a result by Pach and Toth.","lang":"eng"}],"type":"journal_article","external_id":{"arxiv":["1608.08662"]},"file":[{"date_updated":"2019-10-24T10:54:37Z","creator":"dernst","content_type":"application/pdf","success":1,"file_id":"6967","file_name":"2017_JournalGraphAlgorithms_Fulek.pdf","file_size":573623,"access_level":"open_access","date_created":"2019-10-24T10:54:37Z","relation":"main_file"}],"project":[{"name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","call_identifier":"FP7"}],"month":"01","volume":21,"acknowledgement":"An earlier version of the paper appeared in the proceedings of Graph Drawing 2015.  The research of the first author has received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no [291734].","doi":"10.7155/jgaa.00408","quality_controlled":"1","oa_version":"Published Version","has_accepted_license":"1","issue":"1","date_updated":"2025-09-23T09:13:42Z","day":"01","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Fulek, Radoslav, et al. “Hanani-Tutte for Radial Planarity.” <i>Journal of Graph Algorithms and Applications</i>, vol. 21, no. 1, Brown University, 2017, pp. 135–54, doi:<a href=\"https://doi.org/10.7155/jgaa.00408\">10.7155/jgaa.00408</a>.","apa":"Fulek, R., Pelsmajer, M., &#38; Schaefer, M. (2017). Hanani-Tutte for radial planarity. <i>Journal of Graph Algorithms and Applications</i>. Brown University. <a href=\"https://doi.org/10.7155/jgaa.00408\">https://doi.org/10.7155/jgaa.00408</a>","short":"R. Fulek, M. Pelsmajer, M. Schaefer, Journal of Graph Algorithms and Applications 21 (2017) 135–154.","chicago":"Fulek, Radoslav, Michael Pelsmajer, and Marcus Schaefer. “Hanani-Tutte for Radial Planarity.” <i>Journal of Graph Algorithms and Applications</i>. Brown University, 2017. <a href=\"https://doi.org/10.7155/jgaa.00408\">https://doi.org/10.7155/jgaa.00408</a>.","ista":"Fulek R, Pelsmajer M, Schaefer M. 2017. Hanani-Tutte for radial planarity. Journal of Graph Algorithms and Applications. 21(1), 135–154.","ieee":"R. Fulek, M. Pelsmajer, and M. Schaefer, “Hanani-Tutte for radial planarity,” <i>Journal of Graph Algorithms and Applications</i>, vol. 21, no. 1. Brown University, pp. 135–154, 2017.","ama":"Fulek R, Pelsmajer M, Schaefer M. Hanani-Tutte for radial planarity. <i>Journal of Graph Algorithms and Applications</i>. 2017;21(1):135-154. doi:<a href=\"https://doi.org/10.7155/jgaa.00408\">10.7155/jgaa.00408</a>"},"article_type":"original","year":"2017","ec_funded":1,"_id":"1113","publist_id":"6254","intvolume":"        21"},{"date_created":"2018-12-11T11:50:13Z","article_processing_charge":"Yes","status":"public","title":"Observation of the photon blockade breakdown phase transition","publication":"Physical Review X","language":[{"iso":"eng"}],"external_id":{"isi":["000397450500001"]},"article_number":"011012","file":[{"date_created":"2018-12-12T10:12:52Z","relation":"main_file","access_level":"open_access","file_size":1172926,"file_name":"IST-2017-753-v1+1_PhysRevX.7.011012.pdf","file_id":"4972","content_type":"application/pdf","date_updated":"2018-12-12T10:12:52Z","creator":"system"}],"ddc":["539"],"abstract":[{"text":"Nonequilibrium phase transitions exist in damped-driven open quantum systems when the continuous tuning of an external parameter leads to a transition between two robust steady states. In second-order transitions this change is abrupt at a critical point, whereas in first-order transitions the two phases can coexist in a critical hysteresis domain. Here, we report the observation of a first-order dissipative quantum phase transition in a driven circuit quantum electrodynamics system. It takes place when the photon blockade of the driven cavity-atom system is broken by increasing the drive power. The observed experimental signature is a bimodal phase space distribution with varying weights controlled by the drive strength. Our measurements show an improved stabilization of the classical attractors up to the millisecond range when the size of the quantum system is increased from one to three artificial atoms. The formation of such robust pointer states could be used for new quantum measurement schemes or to investigate multiphoton phases of finite-size, nonlinear, open quantum systems.","lang":"eng"}],"type":"journal_article","date_published":"2017-01-31T00:00:00Z","scopus_import":"1","publisher":"American Physical Society","author":[{"id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes M","last_name":"Fink","orcid":"0000-0001-8112-028X","full_name":"Fink, Johannes M"},{"first_name":"András","full_name":"Dombi, András","last_name":"Dombi"},{"full_name":"Vukics, András","last_name":"Vukics","first_name":"András"},{"first_name":"Andreas","last_name":"Wallraff","full_name":"Wallraff, Andreas"},{"first_name":"Peter","last_name":"Domokos","full_name":"Domokos, Peter"}],"department":[{"_id":"JoFi"}],"publication_identifier":{"issn":["2160-3308"]},"publication_status":"published","oa":1,"file_date_updated":"2018-12-12T10:12:52Z","has_accepted_license":"1","issue":"1","doi":"10.1103/PhysRevX.7.011012","oa_version":"Published Version","quality_controlled":"1","pubrep_id":"753","month":"01","volume":7,"_id":"1114","intvolume":"         7","publist_id":"6252","year":"2017","citation":{"mla":"Fink, Johannes M., et al. “Observation of the Photon Blockade Breakdown Phase Transition.” <i>Physical Review X</i>, vol. 7, no. 1, 011012, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevX.7.011012\">10.1103/PhysRevX.7.011012</a>.","apa":"Fink, J. M., Dombi, A., Vukics, A., Wallraff, A., &#38; Domokos, P. (2017). Observation of the photon blockade breakdown phase transition. <i>Physical Review X</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevX.7.011012\">https://doi.org/10.1103/PhysRevX.7.011012</a>","short":"J.M. Fink, A. Dombi, A. Vukics, A. Wallraff, P. Domokos, Physical Review X 7 (2017).","ista":"Fink JM, Dombi A, Vukics A, Wallraff A, Domokos P. 2017. Observation of the photon blockade breakdown phase transition. Physical Review X. 7(1), 011012.","chicago":"Fink, Johannes M, András Dombi, András Vukics, Andreas Wallraff, and Peter Domokos. “Observation of the Photon Blockade Breakdown Phase Transition.” <i>Physical Review X</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevX.7.011012\">https://doi.org/10.1103/PhysRevX.7.011012</a>.","ama":"Fink JM, Dombi A, Vukics A, Wallraff A, Domokos P. Observation of the photon blockade breakdown phase transition. <i>Physical Review X</i>. 2017;7(1). doi:<a href=\"https://doi.org/10.1103/PhysRevX.7.011012\">10.1103/PhysRevX.7.011012</a>","ieee":"J. M. Fink, A. Dombi, A. Vukics, A. Wallraff, and P. Domokos, “Observation of the photon blockade breakdown phase transition,” <i>Physical Review X</i>, vol. 7, no. 1. American Physical Society, 2017."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","isi":1,"date_updated":"2025-07-10T11:50:07Z","day":"31","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"}},{"corr_author":"1","language":[{"iso":"eng"}],"conference":{"name":"TACAS: Tools and Algorithms for the Construction and Analysis of Systems","start_date":"2017-04-22","end_date":"2017-04-29","location":"Uppsala, Sweden"},"title":"Computing scores of forwarding schemes in switched networks with probabilistic faults","alternative_title":["LNCS"],"page":"169 - 187","date_created":"2018-12-11T11:50:14Z","article_processing_charge":"No","status":"public","department":[{"_id":"ToHe"}],"publication_identifier":{"issn":["03029743"]},"publication_status":"published","oa":1,"file_date_updated":"2018-12-12T10:08:37Z","author":[{"first_name":"Guy","id":"463C8BC2-F248-11E8-B48F-1D18A9856A87","last_name":"Avni","orcid":"0000-0001-5588-8287","full_name":"Avni, Guy"},{"last_name":"Goel","full_name":"Goel, Shubham","first_name":"Shubham"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","full_name":"Henzinger, Thomas A","last_name":"Henzinger","orcid":"0000−0002−2985−7724"},{"last_name":"Rodríguez Navas","full_name":"Rodríguez Navas, Guillermo","first_name":"Guillermo"}],"date_published":"2017-03-31T00:00:00Z","abstract":[{"text":"Time-triggered switched networks are a deterministic communication infrastructure used by real-time distributed embedded systems. Due to the criticality of the applications running over them, developers need to ensure that end-to-end communication is dependable and predictable. Traditional approaches assume static networks that are not flexible to changes caused by reconfigurations or, more importantly, faults, which are dealt with in the application using redundancy. We adopt the concept of handling faults in the switches from non-real-time networks while maintaining the required predictability. \r\n\r\nWe study a class of forwarding schemes that can handle various types of failures. We consider probabilistic failures. We study a class of forwarding schemes that can handle various types of failures. We consider probabilistic failures. For a given network with a forwarding scheme and a constant ℓ, we compute the {\\em score} of the scheme, namely the probability (induced by faults) that at least ℓ messages arrive on time. We reduce the scoring problem to a reachability problem on a Markov chain with a &quot;product-like&quot; structure. Its special structure allows us to reason about it symbolically, and reduce the scoring problem to #SAT. Our solution is generic and can be adapted to different networks and other contexts. Also, we show the computational complexity of the scoring problem is #P-complete, and we study methods to estimate the score. We evaluate the effectiveness of our techniques with an implementation. ","lang":"eng"}],"type":"conference","scopus_import":"1","publisher":"Springer","ddc":["000"],"file":[{"relation":"main_file","date_created":"2018-12-12T10:08:37Z","file_name":"IST-2017-758-v1+1_tacas-cr.pdf","file_id":"4698","file_size":321800,"access_level":"open_access","content_type":"application/pdf","creator":"system","date_updated":"2018-12-12T10:08:37Z"}],"external_id":{"isi":["000440733400010"]},"project":[{"call_identifier":"FWF","_id":"25F5A88A-B435-11E9-9278-68D0E5697425","name":"Moderne Concurrency Paradigms","grant_number":"S11402-N23"},{"call_identifier":"FWF","grant_number":"Z211","name":"Formal methods for the design and analysis of complex systems","_id":"25F42A32-B435-11E9-9278-68D0E5697425"}],"volume":10206,"month":"03","pubrep_id":"758","oa_version":"Submitted Version","quality_controlled":"1","doi":"10.1007/978-3-662-54580-5_10","has_accepted_license":"1","isi":1,"day":"31","date_updated":"2025-04-15T06:25:58Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ama":"Avni G, Goel S, Henzinger TA, Rodríguez Navas G. Computing scores of forwarding schemes in switched networks with probabilistic faults. In: Vol 10206. Springer; 2017:169-187. doi:<a href=\"https://doi.org/10.1007/978-3-662-54580-5_10\">10.1007/978-3-662-54580-5_10</a>","ista":"Avni G, Goel S, Henzinger TA, Rodríguez Navas G. 2017. Computing scores of forwarding schemes in switched networks with probabilistic faults. TACAS: Tools and Algorithms for the Construction and Analysis of Systems, LNCS, vol. 10206, 169–187.","ieee":"G. Avni, S. Goel, T. A. Henzinger, and G. Rodríguez Navas, “Computing scores of forwarding schemes in switched networks with probabilistic faults,” presented at the TACAS: Tools and Algorithms for the Construction and Analysis of Systems, Uppsala, Sweden, 2017, vol. 10206, pp. 169–187.","chicago":"Avni, Guy, Shubham Goel, Thomas A Henzinger, and Guillermo Rodríguez Navas. “Computing Scores of Forwarding Schemes in Switched Networks with Probabilistic Faults,” 10206:169–87. Springer, 2017. <a href=\"https://doi.org/10.1007/978-3-662-54580-5_10\">https://doi.org/10.1007/978-3-662-54580-5_10</a>.","short":"G. Avni, S. Goel, T.A. Henzinger, G. Rodríguez Navas, in:, Springer, 2017, pp. 169–187.","apa":"Avni, G., Goel, S., Henzinger, T. A., &#38; Rodríguez Navas, G. (2017). Computing scores of forwarding schemes in switched networks with probabilistic faults (Vol. 10206, pp. 169–187). Presented at the TACAS: Tools and Algorithms for the Construction and Analysis of Systems, Uppsala, Sweden: Springer. <a href=\"https://doi.org/10.1007/978-3-662-54580-5_10\">https://doi.org/10.1007/978-3-662-54580-5_10</a>","mla":"Avni, Guy, et al. <i>Computing Scores of Forwarding Schemes in Switched Networks with Probabilistic Faults</i>. Vol. 10206, Springer, 2017, pp. 169–87, doi:<a href=\"https://doi.org/10.1007/978-3-662-54580-5_10\">10.1007/978-3-662-54580-5_10</a>."},"year":"2017","intvolume":"     10206","publist_id":"6246","_id":"1116"},{"year":"2017","ec_funded":1,"publist_id":"6245","intvolume":"        18","_id":"1117","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"day":"17","date_updated":"2025-07-10T11:50:09Z","isi":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"C. Chen,  itaru Arai, R. Satterield, S. Young, P.M. Jonas, Cell Reports 18 (2017) 723–736.","ista":"Chen C, Arai  itaru, Satterield R, Young S, Jonas PM. 2017. Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse. Cell Reports. 18(3), 723–736.","chicago":"Chen, Chong, itaru Arai, Rachel Satterield, Samuel Young, and Peter M Jonas. “Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse.” <i>Cell Reports</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.celrep.2016.12.067\">https://doi.org/10.1016/j.celrep.2016.12.067</a>.","ama":"Chen C, Arai  itaru, Satterield R, Young S, Jonas PM. Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse. <i>Cell Reports</i>. 2017;18(3):723-736. doi:<a href=\"https://doi.org/10.1016/j.celrep.2016.12.067\">10.1016/j.celrep.2016.12.067</a>","ieee":"C. Chen,  itaru Arai, R. Satterield, S. Young, and P. M. Jonas, “Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse,” <i>Cell Reports</i>, vol. 18, no. 3. Cell Press, pp. 723–736, 2017.","mla":"Chen, Chong, et al. “Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse.” <i>Cell Reports</i>, vol. 18, no. 3, Cell Press, 2017, pp. 723–36, doi:<a href=\"https://doi.org/10.1016/j.celrep.2016.12.067\">10.1016/j.celrep.2016.12.067</a>.","apa":"Chen, C., Arai,  itaru, Satterield, R., Young, S., &#38; Jonas, P. M. (2017). Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse. <i>Cell Reports</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.celrep.2016.12.067\">https://doi.org/10.1016/j.celrep.2016.12.067</a>"},"quality_controlled":"1","oa_version":"Published Version","doi":"10.1016/j.celrep.2016.12.067","issue":"3","has_accepted_license":"1","volume":18,"month":"01","pubrep_id":"751","file":[{"date_created":"2018-12-12T10:16:09Z","relation":"main_file","file_name":"IST-2017-751-v1+1_1-s2.0-S2211124716317740-main.pdf","file_id":"5195","access_level":"open_access","file_size":4427591,"content_type":"application/pdf","date_updated":"2018-12-12T10:16:09Z","creator":"system"}],"external_id":{"isi":["000396470600013"]},"project":[{"name":"Mechanisms of transmitter release at GABAergic synapses","_id":"25C26B1E-B435-11E9-9278-68D0E5697425","grant_number":"P24909-B24","call_identifier":"FWF"},{"call_identifier":"FP7","grant_number":"268548","name":"Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons","_id":"25C0F108-B435-11E9-9278-68D0E5697425"}],"oa":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"file_date_updated":"2018-12-12T10:16:09Z","related_material":{"record":[{"id":"324","status":"public","relation":"dissertation_contains"}]},"publication_identifier":{"issn":["2211-1247"]},"publication_status":"published","department":[{"_id":"PeJo"}],"author":[{"last_name":"Chen","full_name":"Chen, Chong","id":"3DFD581A-F248-11E8-B48F-1D18A9856A87","first_name":"Chong"},{"last_name":"Arai","full_name":"Arai, Itaru","id":"32A73F6C-F248-11E8-B48F-1D18A9856A87","first_name":"Itaru"},{"first_name":"Rachel","full_name":"Satterield, Rachel","last_name":"Satterield"},{"first_name":"Samuel","full_name":"Young, Samuel","last_name":"Young"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","full_name":"Jonas, Peter M","last_name":"Jonas","orcid":"0000-0001-5001-4804"}],"publisher":"Cell Press","scopus_import":"1","date_published":"2017-01-17T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we examined the Ca^2+ sensor of exocytosis at GABAergic basket cell (BC) to Purkinje cell (PC) synapses in cerebellum. Immunolabeling suggested that BC terminals selectively expressed synaptotagmin 2 (Syt2), whereas synaptotagmin 1 (Syt1) was enriched in excitatory terminals. Genetic elimination of Syt2 reduced action potential-evoked release to ∼10%, identifying Syt2 as the major Ca^2+ sensor at BC-PC synapses. Differential adenovirus-mediated rescue revealed that Syt2 triggered release with shorter latency and higher temporal precision and mediated faster vesicle pool replenishment than Syt1. Furthermore, deletion of Syt2 severely reduced and delayed disynaptic inhibition following parallel fiber stimulation. Thus, the selective use of Syt2 as release sensor at BC-PC synapses ensures fast and efficient feedforward inhibition in cerebellar microcircuits. #bioimagingfacility-author"}],"ddc":["571"],"publication":"Cell Reports","title":"Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse","page":"723 - 736","status":"public","date_created":"2018-12-11T11:50:14Z","article_processing_charge":"No","language":[{"iso":"eng"}]},{"author":[{"first_name":"Jian","id":"3614E438-F248-11E8-B48F-1D18A9856A87","last_name":"Gan","full_name":"Gan, Jian"},{"first_name":"Shih-Ming","id":"2F9C5AC8-F248-11E8-B48F-1D18A9856A87","full_name":"Weng, Shih-Ming","last_name":"Weng"},{"id":"36963E98-F248-11E8-B48F-1D18A9856A87","first_name":"Alejandro","full_name":"Pernia-Andrade, Alejandro","last_name":"Pernia-Andrade"},{"last_name":"Csicsvari","orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas"}],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"ScienComp"},{"_id":"PreCl"}],"oa":1,"file_date_updated":"2018-12-12T10:08:56Z","department":[{"_id":"PeJo"},{"_id":"JoCs"}],"publication_status":"published","ddc":["571"],"publisher":"Elsevier","scopus_import":"1","type":"journal_article","date_published":"2017-01-18T00:00:00Z","abstract":[{"lang":"eng","text":"Sharp wave-ripple (SWR) oscillations play a key role in memory consolidation during non-rapid eye movement sleep, immobility, and consummatory behavior. However, whether temporally modulated synaptic excitation or inhibition underlies the ripples is controversial. To address this question, we performed simultaneous recordings of excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) and local field potentials (LFPs) in the CA1 region of awake mice in vivo. During SWRs, inhibition dominated over excitation, with a peak conductance ratio of 4.1 ± 0.5. Furthermore, the amplitude of SWR-associated IPSCs was positively correlated with SWR magnitude, whereas that of EPSCs was not. Finally, phase analysis indicated that IPSCs were phase-locked to individual ripple cycles, whereas EPSCs were uniformly distributed in phase space. Optogenetic inhibition indicated that PV+ interneurons provided a major contribution to SWR-associated IPSCs. Thus, phasic inhibition, but not excitation, shapes SWR oscillations in the hippocampal CA1 region in vivo."}],"external_id":{"isi":["000396428200010"]},"file":[{"file_name":"IST-2017-752-v1+1_1-s2.0-S0896627316309606-main.pdf","file_id":"4719","file_size":2738950,"access_level":"open_access","relation":"main_file","date_created":"2018-12-12T10:08:56Z","creator":"system","date_updated":"2018-12-12T10:08:56Z","content_type":"application/pdf"}],"project":[{"call_identifier":"FWF","_id":"25C26B1E-B435-11E9-9278-68D0E5697425","name":"Mechanisms of transmitter release at GABAergic synapses","grant_number":"P24909-B24"},{"call_identifier":"FP7","grant_number":"268548","name":"Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons","_id":"25C0F108-B435-11E9-9278-68D0E5697425"}],"language":[{"iso":"eng"}],"title":"Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo","publication":"Neuron","status":"public","date_created":"2018-12-11T11:50:15Z","article_processing_charge":"No","page":"308 - 314","date_updated":"2025-04-15T07:20:01Z","day":"18","isi":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"apa":"Gan, J., Weng, S.-M., Pernia-Andrade, A., Csicsvari, J. L., &#38; Jonas, P. M. (2017). Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2016.12.018\">https://doi.org/10.1016/j.neuron.2016.12.018</a>","mla":"Gan, Jian, et al. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice in Vivo.” <i>Neuron</i>, vol. 93, no. 2, Elsevier, 2017, pp. 308–14, doi:<a href=\"https://doi.org/10.1016/j.neuron.2016.12.018\">10.1016/j.neuron.2016.12.018</a>.","chicago":"Gan, Jian, Shih-Ming Weng, Alejandro Pernia-Andrade, Jozsef L Csicsvari, and Peter M Jonas. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice in Vivo.” <i>Neuron</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.neuron.2016.12.018\">https://doi.org/10.1016/j.neuron.2016.12.018</a>.","ama":"Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo. <i>Neuron</i>. 2017;93(2):308-314. doi:<a href=\"https://doi.org/10.1016/j.neuron.2016.12.018\">10.1016/j.neuron.2016.12.018</a>","ieee":"J. Gan, S.-M. Weng, A. Pernia-Andrade, J. L. Csicsvari, and P. M. Jonas, “Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo,” <i>Neuron</i>, vol. 93, no. 2. Elsevier, pp. 308–314, 2017.","ista":"Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. 2017. Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo. Neuron. 93(2), 308–314.","short":"J. Gan, S.-M. Weng, A. Pernia-Andrade, J.L. Csicsvari, P.M. Jonas, Neuron 93 (2017) 308–314."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","year":"2017","ec_funded":1,"_id":"1118","publist_id":"6244","intvolume":"        93","month":"01","volume":93,"pubrep_id":"752","doi":"10.1016/j.neuron.2016.12.018","quality_controlled":"1","oa_version":"Published Version","has_accepted_license":"1","issue":"2"},{"quality_controlled":"1","oa_version":"Submitted Version","doi":"10.1103/PhysRevLett.118.095301","issue":"9","volume":118,"month":"02","year":"2017","publist_id":"6243","intvolume":"       118","_id":"1119","date_updated":"2025-06-04T08:36:48Z","day":"27","isi":1,"citation":{"short":"M. Lemeshko, Physical Review Letters 118 (2017).","ista":"Lemeshko M. 2017. Quasiparticle approach to molecules interacting with quantum solvents. Physical Review Letters. 118(9), 095301.","ieee":"M. Lemeshko, “Quasiparticle approach to molecules interacting with quantum solvents,” <i>Physical Review Letters</i>, vol. 118, no. 9. American Physical Society, 2017.","ama":"Lemeshko M. Quasiparticle approach to molecules interacting with quantum solvents. <i>Physical Review Letters</i>. 2017;118(9). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.095301\">10.1103/PhysRevLett.118.095301</a>","chicago":"Lemeshko, Mikhail. “Quasiparticle Approach to Molecules Interacting with Quantum Solvents.” <i>Physical Review Letters</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevLett.118.095301\">https://doi.org/10.1103/PhysRevLett.118.095301</a>.","mla":"Lemeshko, Mikhail. “Quasiparticle Approach to Molecules Interacting with Quantum Solvents.” <i>Physical Review Letters</i>, vol. 118, no. 9, 095301, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.095301\">10.1103/PhysRevLett.118.095301</a>.","apa":"Lemeshko, M. (2017). Quasiparticle approach to molecules interacting with quantum solvents. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.118.095301\">https://doi.org/10.1103/PhysRevLett.118.095301</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Physical Review Letters","title":"Quasiparticle approach to molecules interacting with quantum solvents","status":"public","date_created":"2018-12-11T11:50:15Z","article_processing_charge":"No","language":[{"iso":"eng"}],"arxiv":1,"main_file_link":[{"url":"https://arxiv.org/abs/1610.01604","open_access":"1"}],"article_number":"095301","external_id":{"arxiv":["1610.01604"],"isi":["000404769200006"]},"project":[{"name":"Genome-wide Analysis of Root Traits","_id":"25636330-B435-11E9-9278-68D0E5697425","grant_number":"11-NSF-1070"}],"oa":1,"publication_status":"published","department":[{"_id":"MiLe"}],"publication_identifier":{"issn":["0031-9007"]},"author":[{"id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail","orcid":"0000-0002-6990-7802","last_name":"Lemeshko","full_name":"Lemeshko, Mikhail"}],"publisher":"American Physical Society","scopus_import":"1","abstract":[{"lang":"eng","text":"Understanding the behavior of molecules interacting with superfluid helium represents a formidable challenge and, in general, requires approaches relying on large-scale numerical simulations. Here we demonstrate that experimental data collected over the last 20 years provide evidence that molecules immersed in superfluid helium form recently-predicted angulon quasiparticles [Phys. Rev. Lett. 114, 203001 (2015)]. Most importantly, casting the many-body problem in terms of angulons amounts to a drastic simplification and yields effective molecular moments of inertia as straightforward analytic solutions of a simple microscopic Hamiltonian. The outcome of the angulon theory is in good agreement with experiment for a broad range of molecular impurities, from heavy to medium-mass to light species. These results pave the way to understanding molecular rotation in liquid and crystalline phases in terms of the angulon quasiparticle."}],"date_published":"2017-02-27T00:00:00Z","type":"journal_article"},{"scopus_import":"1","publisher":"American Physical Society","date_published":"2017-03-06T00:00:00Z","abstract":[{"text":"The existence of a self-localization transition in the polaron problem has been under an active debate ever since Landau suggested it 83 years ago. Here we reveal the self-localization transition for the rotational analogue of the polaron -- the angulon quasiparticle. We show that, unlike for the polarons, self-localization of angulons occurs at finite impurity-bath coupling already at the mean-field level. The transition is accompanied by the spherical-symmetry breaking of the angulon ground state and a discontinuity in the first derivative of the ground-state energy. Moreover, the type of the symmetry breaking is dictated by the symmetry of the microscopic impurity-bath interaction, which leads to a number of distinct self-localized states. The predicted effects can potentially be addressed in experiments on cold molecules trapped in superfluid helium droplets and ultracold quantum gases, as well as on electronic excitations in solids and Bose-Einstein condensates. ","lang":"eng"}],"type":"journal_article","oa":1,"related_material":{"record":[{"id":"8958","relation":"dissertation_contains","status":"public"}]},"publication_identifier":{"issn":["2469-9926"]},"publication_status":"published","department":[{"_id":"MiLe"},{"_id":"RoSe"}],"author":[{"full_name":"Li, Xiang","last_name":"Li","first_name":"Xiang","id":"4B7E523C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Seiringer, Robert","last_name":"Seiringer","orcid":"0000-0002-6781-0521","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","last_name":"Lemeshko","orcid":"0000-0002-6990-7802","full_name":"Lemeshko, Mikhail"}],"project":[{"grant_number":"694227","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems","call_identifier":"H2020"},{"grant_number":"P27533_N27","_id":"25C878CE-B435-11E9-9278-68D0E5697425","name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems","call_identifier":"FWF"},{"call_identifier":"FWF","_id":"26031614-B435-11E9-9278-68D0E5697425","name":"Quantum rotations in the presence of a many-body environment","grant_number":"P29902"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1610.04908"}],"external_id":{"isi":["000395981900009"],"arxiv":["1610.04908"]},"article_number":"033608","language":[{"iso":"eng"}],"arxiv":1,"status":"public","article_processing_charge":"No","date_created":"2018-12-11T11:50:15Z","publication":"Physical Review A","title":"Angular self-localization of impurities rotating in a bosonic bath","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Li, Xiang, et al. “Angular Self-Localization of Impurities Rotating in a Bosonic Bath.” <i>Physical Review A</i>, vol. 95, no. 3, 033608, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevA.95.033608\">10.1103/PhysRevA.95.033608</a>.","apa":"Li, X., Seiringer, R., &#38; Lemeshko, M. (2017). Angular self-localization of impurities rotating in a bosonic bath. <i>Physical Review A</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevA.95.033608\">https://doi.org/10.1103/PhysRevA.95.033608</a>","short":"X. Li, R. Seiringer, M. Lemeshko, Physical Review A 95 (2017).","ama":"Li X, Seiringer R, Lemeshko M. Angular self-localization of impurities rotating in a bosonic bath. <i>Physical Review A</i>. 2017;95(3). doi:<a href=\"https://doi.org/10.1103/PhysRevA.95.033608\">10.1103/PhysRevA.95.033608</a>","ieee":"X. Li, R. Seiringer, and M. Lemeshko, “Angular self-localization of impurities rotating in a bosonic bath,” <i>Physical Review A</i>, vol. 95, no. 3. American Physical Society, 2017.","ista":"Li X, Seiringer R, Lemeshko M. 2017. Angular self-localization of impurities rotating in a bosonic bath. Physical Review A. 95(3), 033608.","chicago":"Li, Xiang, Robert Seiringer, and Mikhail Lemeshko. “Angular Self-Localization of Impurities Rotating in a Bosonic Bath.” <i>Physical Review A</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevA.95.033608\">https://doi.org/10.1103/PhysRevA.95.033608</a>."},"day":"06","date_updated":"2025-06-04T08:37:18Z","isi":1,"publist_id":"6242","intvolume":"        95","_id":"1120","year":"2017","ec_funded":1,"volume":95,"month":"03","issue":"3","quality_controlled":"1","oa_version":"Published Version","doi":"10.1103/PhysRevA.95.033608"}]