[{"date_published":"2017-06-01T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1510.01290"}],"corr_author":"1","department":[{"_id":"CaUh"}],"publication_status":"published","intvolume":"        45","publist_id":"6288","publication_identifier":{"issn":["0090-5364"]},"author":[{"full_name":"Fallat, Shaun","last_name":"Fallat","first_name":"Shaun"},{"full_name":"Lauritzen, Steffen","first_name":"Steffen","last_name":"Lauritzen"},{"full_name":"Sadeghi, Kayvan","last_name":"Sadeghi","first_name":"Kayvan"},{"orcid":"0000-0002-7008-0216","full_name":"Uhler, Caroline","id":"49ADD78E-F248-11E8-B48F-1D18A9856A87","first_name":"Caroline","last_name":"Uhler"},{"full_name":"Wermuth, Nanny","last_name":"Wermuth","first_name":"Nanny"},{"full_name":"Zwiernik, Piotr","first_name":"Piotr","last_name":"Zwiernik"}],"arxiv":1,"date_created":"2018-12-11T11:50:05Z","isi":1,"month":"06","status":"public","year":"2017","quality_controlled":"1","title":"Total positivity in Markov structures","scopus_import":"1","external_id":{"isi":["000404395900008"],"arxiv":["1510.01290"]},"doi":"10.1214/16-AOS1478","oa_version":"Submitted Version","publication":"Annals of Statistics","article_processing_charge":"No","page":"1152 - 1184","publisher":"Institute of Mathematical Statistics","day":"01","_id":"1089","issue":"3","citation":{"chicago":"Fallat, Shaun, Steffen Lauritzen, Kayvan Sadeghi, Caroline Uhler, Nanny Wermuth, and Piotr Zwiernik. “Total Positivity in Markov Structures.” <i>Annals of Statistics</i>. Institute of Mathematical Statistics, 2017. <a href=\"https://doi.org/10.1214/16-AOS1478\">https://doi.org/10.1214/16-AOS1478</a>.","ieee":"S. Fallat, S. Lauritzen, K. Sadeghi, C. Uhler, N. Wermuth, and P. Zwiernik, “Total positivity in Markov structures,” <i>Annals of Statistics</i>, vol. 45, no. 3. Institute of Mathematical Statistics, pp. 1152–1184, 2017.","apa":"Fallat, S., Lauritzen, S., Sadeghi, K., Uhler, C., Wermuth, N., &#38; Zwiernik, P. (2017). Total positivity in Markov structures. <i>Annals of Statistics</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/16-AOS1478\">https://doi.org/10.1214/16-AOS1478</a>","ista":"Fallat S, Lauritzen S, Sadeghi K, Uhler C, Wermuth N, Zwiernik P. 2017. Total positivity in Markov structures. Annals of Statistics. 45(3), 1152–1184.","mla":"Fallat, Shaun, et al. “Total Positivity in Markov Structures.” <i>Annals of Statistics</i>, vol. 45, no. 3, Institute of Mathematical Statistics, 2017, pp. 1152–84, doi:<a href=\"https://doi.org/10.1214/16-AOS1478\">10.1214/16-AOS1478</a>.","ama":"Fallat S, Lauritzen S, Sadeghi K, Uhler C, Wermuth N, Zwiernik P. Total positivity in Markov structures. <i>Annals of Statistics</i>. 2017;45(3):1152-1184. doi:<a href=\"https://doi.org/10.1214/16-AOS1478\">10.1214/16-AOS1478</a>","short":"S. Fallat, S. Lauritzen, K. Sadeghi, C. Uhler, N. Wermuth, P. Zwiernik, Annals of Statistics 45 (2017) 1152–1184."},"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We discuss properties of distributions that are multivariate totally positive of order two (MTP2) related to conditional independence. In particular, we show that any independence model generated by an MTP2 distribution is a compositional semigraphoid which is upward-stable and singleton-transitive. In addition, we prove that any MTP2 distribution satisfying an appropriate support condition is faithful to its concentration graph. Finally, we analyze factorization properties of MTP2 distributions and discuss ways of constructing MTP2 distributions; in particular we give conditions on the log-linear parameters of a discrete distribution which ensure MTP2 and characterize conditional Gaussian distributions which satisfy MTP2."}],"date_updated":"2025-06-04T08:35:37Z","type":"journal_article","volume":45,"project":[{"name":"Gaussian Graphical Models: Theory and Applications","call_identifier":"FWF","grant_number":"Y 903-N35","_id":"2530CA10-B435-11E9-9278-68D0E5697425"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1},{"_id":"1104","publisher":"Nature Publishing Group","day":"06","volume":8,"type":"journal_article","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"Localization of ion channels and receptors by two and three-dimensional immunoelectron microscopic approaches","call_identifier":"FP7","_id":"25CD3DD2-B435-11E9-9278-68D0E5697425","grant_number":"604102"},{"_id":"254D1A94-B435-11E9-9278-68D0E5697425","grant_number":"P 25651-N26","call_identifier":"FWF","name":"Sensitivity to higher-order statistics in natural scenes"}],"abstract":[{"text":"In the early visual system, cells of the same type perform the same computation in different places of the visual field. How these cells code together a complex visual scene is unclear. A common assumption is that cells of a single-type extract a single-stimulus feature to form a feature map, but this has rarely been observed directly. Using large-scale recordings in the rat retina, we show that a homogeneous population of fast OFF ganglion cells simultaneously encodes two radically different features of a visual scene. Cells close to a moving object code quasilinearly for its position, while distant cells remain largely invariant to the object's position and, instead, respond nonlinearly to changes in the object's speed. We develop a quantitative model that accounts for this effect and identify a disinhibitory circuit that mediates it. Ganglion cells of a single type thus do not code for one, but two features simultaneously. This richer, flexible neural map might also be present in other sensory systems.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2025-07-10T11:50:05Z","citation":{"apa":"Deny, S., Ferrari, U., Mace, E., Yger, P., Caplette, R., Picaud, S., … Marre, O. (2017). Multiplexed computations in retinal ganglion cells of a single type. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-017-02159-y\">https://doi.org/10.1038/s41467-017-02159-y</a>","chicago":"Deny, Stephane, Ulisse Ferrari, Emilie Mace, Pierre Yger, Romain Caplette, Serge Picaud, Gašper Tkačik, and Olivier Marre. “Multiplexed Computations in Retinal Ganglion Cells of a Single Type.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/s41467-017-02159-y\">https://doi.org/10.1038/s41467-017-02159-y</a>.","ieee":"S. Deny <i>et al.</i>, “Multiplexed computations in retinal ganglion cells of a single type,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017.","ista":"Deny S, Ferrari U, Mace E, Yger P, Caplette R, Picaud S, Tkačik G, Marre O. 2017. Multiplexed computations in retinal ganglion cells of a single type. Nature Communications. 8(1), 1964.","mla":"Deny, Stephane, et al. “Multiplexed Computations in Retinal Ganglion Cells of a Single Type.” <i>Nature Communications</i>, vol. 8, no. 1, 1964, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-02159-y\">10.1038/s41467-017-02159-y</a>.","short":"S. Deny, U. Ferrari, E. Mace, P. Yger, R. Caplette, S. Picaud, G. Tkačik, O. Marre, Nature Communications 8 (2017).","ama":"Deny S, Ferrari U, Mace E, et al. Multiplexed computations in retinal ganglion cells of a single type. <i>Nature Communications</i>. 2017;8(1). doi:<a href=\"https://doi.org/10.1038/s41467-017-02159-y\">10.1038/s41467-017-02159-y</a>"},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","issue":"1","article_number":"1964","status":"public","month":"12","year":"2017","author":[{"first_name":"Stephane","last_name":"Deny","full_name":"Deny, Stephane"},{"full_name":"Ferrari, Ulisse","last_name":"Ferrari","first_name":"Ulisse"},{"full_name":"Mace, Emilie","first_name":"Emilie","last_name":"Mace"},{"first_name":"Pierre","last_name":"Yger","full_name":"Yger, Pierre"},{"first_name":"Romain","last_name":"Caplette","full_name":"Caplette, Romain"},{"first_name":"Serge","last_name":"Picaud","full_name":"Picaud, Serge"},{"orcid":"0000-0002-6699-1455","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","full_name":"Tkacik, Gasper","first_name":"Gasper","last_name":"Tkacik"},{"first_name":"Olivier","last_name":"Marre","full_name":"Marre, Olivier"}],"publication_identifier":{"issn":["2041-1723"]},"publist_id":"6266","intvolume":"         8","isi":1,"date_created":"2018-12-11T11:50:10Z","pubrep_id":"921","department":[{"_id":"GaTk"}],"publication_status":"published","ec_funded":1,"date_published":"2017-12-06T00:00:00Z","article_processing_charge":"No","publication":"Nature Communications","doi":"10.1038/s41467-017-02159-y","oa_version":"Published Version","external_id":{"isi":["000417241200004"]},"file_date_updated":"2018-12-12T10:16:06Z","ddc":["571"],"file":[{"access_level":"open_access","file_name":"IST-2018-921-v1+1_s41467-017-02159-y.pdf","date_updated":"2018-12-12T10:16:06Z","date_created":"2018-12-12T10:16:06Z","content_type":"application/pdf","creator":"system","file_id":"5191","file_size":2872887,"relation":"main_file"}],"title":"Multiplexed computations in retinal ganglion cells of a single type","quality_controlled":"1","scopus_import":"1"},{"extern":"1","publisher":"Springer Nature","day":"30","_id":"11065","article_type":"original","article_number":"328","citation":{"ista":"Buchwalter A, Hetzer M. 2017. Nucleolar expansion and elevated protein translation in premature aging. Nature Communications. 8, 328.","apa":"Buchwalter, A., &#38; Hetzer, M. (2017). Nucleolar expansion and elevated protein translation in premature aging. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-017-00322-z\">https://doi.org/10.1038/s41467-017-00322-z</a>","chicago":"Buchwalter, Abigail, and Martin Hetzer. “Nucleolar Expansion and Elevated Protein Translation in Premature Aging.” <i>Nature Communications</i>. Springer Nature, 2017. <a href=\"https://doi.org/10.1038/s41467-017-00322-z\">https://doi.org/10.1038/s41467-017-00322-z</a>.","ieee":"A. Buchwalter and M. Hetzer, “Nucleolar expansion and elevated protein translation in premature aging,” <i>Nature Communications</i>, vol. 8. Springer Nature, 2017.","short":"A. Buchwalter, M. Hetzer, Nature Communications 8 (2017).","ama":"Buchwalter A, Hetzer M. Nucleolar expansion and elevated protein translation in premature aging. <i>Nature Communications</i>. 2017;8. doi:<a href=\"https://doi.org/10.1038/s41467-017-00322-z\">10.1038/s41467-017-00322-z</a>","mla":"Buchwalter, Abigail, and Martin Hetzer. “Nucleolar Expansion and Elevated Protein Translation in Premature Aging.” <i>Nature Communications</i>, vol. 8, 328, Springer Nature, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-00322-z\">10.1038/s41467-017-00322-z</a>."},"abstract":[{"text":"Premature aging disorders provide an opportunity to study the mechanisms that drive aging. In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We sought to investigate protein homeostasis in this disease. Here, we report a widespread increase in protein turnover in HGPS-derived cells compared to normal cells. We determine that global protein synthesis is elevated as a consequence of activated nucleoli and enhanced ribosome biogenesis in HGPS-derived fibroblasts. Depleting normal lamin A or inducing mutant lamin A expression are each sufficient to drive nucleolar expansion. We further show that nucleolar size correlates with donor age in primary fibroblasts derived from healthy individuals and that ribosomal RNA production increases with age, indicating that nucleolar size and activity can serve as aging biomarkers. While limiting ribosome biogenesis extends lifespan in several systems, we show that increased ribosome biogenesis and activity are a hallmark of premature aging.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2024-10-14T11:20:12Z","keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry"],"type":"journal_article","volume":8,"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-017-00322-z"}],"date_published":"2017-08-30T00:00:00Z","publication_status":"published","author":[{"full_name":"Buchwalter, Abigail","first_name":"Abigail","last_name":"Buchwalter"},{"last_name":"HETZER","first_name":"Martin W","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X"}],"intvolume":"         8","publication_identifier":{"issn":["2041-1723"]},"date_created":"2022-04-07T07:45:50Z","status":"public","month":"08","year":"2017","title":"Nucleolar expansion and elevated protein translation in premature aging","quality_controlled":"1","scopus_import":"1","external_id":{"pmid":["28855503"]},"oa_version":"Published Version","doi":"10.1038/s41467-017-00322-z","publication":"Nature Communications","pmid":1,"article_processing_charge":"No"},{"publication_identifier":{"issn":["0890-9369","1549-5477"]},"intvolume":"        31","author":[{"first_name":"Tobias M.","last_name":"Franks","full_name":"Franks, Tobias M."},{"first_name":"Asako","last_name":"McCloskey","full_name":"McCloskey, Asako"},{"full_name":"Shokhirev, Maxim Nikolaievich","last_name":"Shokhirev","first_name":"Maxim Nikolaievich"},{"full_name":"Benner, Chris","first_name":"Chris","last_name":"Benner"},{"full_name":"Rathore, Annie","first_name":"Annie","last_name":"Rathore"},{"orcid":"0000-0002-2111-992X","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","first_name":"Martin W","last_name":"HETZER"}],"date_created":"2022-04-07T07:45:59Z","month":"12","status":"public","year":"2017","main_file_link":[{"url":"https://doi.org/10.1101/gad.306753.117","open_access":"1"}],"date_published":"2017-12-21T00:00:00Z","publication_status":"published","publication":"Genes & Development","pmid":1,"article_processing_charge":"No","quality_controlled":"1","title":"Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells","scopus_import":"1","doi":"10.1101/gad.306753.117","external_id":{"pmid":["29269482"]},"oa_version":"Published Version","extern":"1","publisher":"Cold Spring Harbor Laboratory","day":"21","_id":"11066","article_type":"original","page":"2222-2234","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Recent studies have shown that a subset of nucleoporins (Nups) can detach from the nuclear pore complex and move into the nuclear interior to regulate transcription. One such dynamic Nup, called Nup98, has been implicated in gene activation in healthy cells and has been shown to drive leukemogenesis when mutated in patients with acute myeloid leukemia (AML). Here we show that in hematopoietic cells, Nup98 binds predominantly to transcription start sites to recruit the Wdr82–Set1A/COMPASS (complex of proteins associated with Set1) complex, which is required for deposition of the histone 3 Lys4 trimethyl (H3K4me3)-activating mark. Depletion of Nup98 or Wdr82 abolishes Set1A recruitment to chromatin and subsequently ablates H3K4me3 at adjacent promoters. Furthermore, expression of a Nup98 fusion protein implicated in aggressive AML causes mislocalization of H3K4me3 at abnormal regions and up-regulation of associated genes. Our findings establish a function of Nup98 in hematopoietic gene activation and provide mechanistic insight into which Nup98 leukemic fusion proteins promote AML."}],"date_updated":"2024-10-14T11:20:24Z","type":"journal_article","volume":31,"keyword":["Developmental Biology","Genetics"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"issue":"22","citation":{"mla":"Franks, Tobias M., et al. “Nup98 Recruits the Wdr82–Set1A/COMPASS Complex to Promoters to Regulate H3K4 Trimethylation in Hematopoietic Progenitor Cells.” <i>Genes &#38; Development</i>, vol. 31, no. 22, Cold Spring Harbor Laboratory, 2017, pp. 2222–34, doi:<a href=\"https://doi.org/10.1101/gad.306753.117\">10.1101/gad.306753.117</a>.","ama":"Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. <i>Genes &#38; Development</i>. 2017;31(22):2222-2234. doi:<a href=\"https://doi.org/10.1101/gad.306753.117\">10.1101/gad.306753.117</a>","short":"T.M. Franks, A. McCloskey, M.N. Shokhirev, C. Benner, A. Rathore, M. Hetzer, Genes &#38; Development 31 (2017) 2222–2234.","ieee":"T. M. Franks, A. McCloskey, M. N. Shokhirev, C. Benner, A. Rathore, and M. Hetzer, “Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells,” <i>Genes &#38; Development</i>, vol. 31, no. 22. Cold Spring Harbor Laboratory, pp. 2222–2234, 2017.","chicago":"Franks, Tobias M., Asako McCloskey, Maxim Nikolaievich Shokhirev, Chris Benner, Annie Rathore, and Martin Hetzer. “Nup98 Recruits the Wdr82–Set1A/COMPASS Complex to Promoters to Regulate H3K4 Trimethylation in Hematopoietic Progenitor Cells.” <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory, 2017. <a href=\"https://doi.org/10.1101/gad.306753.117\">https://doi.org/10.1101/gad.306753.117</a>.","apa":"Franks, T. M., McCloskey, A., Shokhirev, M. N., Benner, C., Rathore, A., &#38; Hetzer, M. (2017). Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory. <a href=\"https://doi.org/10.1101/gad.306753.117\">https://doi.org/10.1101/gad.306753.117</a>","ista":"Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. 2017. Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes &#38; Development. 31(22), 2222–2234."}},{"main_file_link":[{"url":"https://doi.org/10.1016/j.stem.2017.08.012","open_access":"1"}],"date_published":"2017-11-02T00:00:00Z","publication_status":"published","date_created":"2022-04-07T07:46:12Z","author":[{"first_name":"Tomohisa","last_name":"Toda","full_name":"Toda, Tomohisa"},{"full_name":"Hsu, Jonathan Y.","last_name":"Hsu","first_name":"Jonathan Y."},{"first_name":"Sara B.","last_name":"Linker","full_name":"Linker, Sara B."},{"full_name":"Hu, Lauren","first_name":"Lauren","last_name":"Hu"},{"first_name":"Simon T.","last_name":"Schafer","full_name":"Schafer, Simon T."},{"full_name":"Mertens, Jerome","first_name":"Jerome","last_name":"Mertens"},{"full_name":"Jacinto, Filipe V.","first_name":"Filipe V.","last_name":"Jacinto"},{"last_name":"HETZER","first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"},{"last_name":"Gage","first_name":"Fred H.","full_name":"Gage, Fred H."}],"intvolume":"        21","publication_identifier":{"issn":["1934-5909"]},"year":"2017","status":"public","month":"11","scopus_import":"1","title":"Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells","quality_controlled":"1","doi":"10.1016/j.stem.2017.08.012","external_id":{"pmid":["28919367"]},"oa_version":"Published Version","pmid":1,"publication":"Cell Stem Cell","article_processing_charge":"No","page":"618-634.e7","publisher":"Elsevier","day":"02","extern":"1","_id":"11067","article_type":"original","issue":"5","citation":{"ama":"Toda T, Hsu JY, Linker SB, et al. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. <i>Cell Stem Cell</i>. 2017;21(5):618-634.e7. doi:<a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">10.1016/j.stem.2017.08.012</a>","short":"T. Toda, J.Y. Hsu, S.B. Linker, L. Hu, S.T. Schafer, J. Mertens, F.V. Jacinto, M. Hetzer, F.H. Gage, Cell Stem Cell 21 (2017) 618–634.e7.","mla":"Toda, Tomohisa, et al. “Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.” <i>Cell Stem Cell</i>, vol. 21, no. 5, Elsevier, 2017, p. 618–634.e7, doi:<a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">10.1016/j.stem.2017.08.012</a>.","ista":"Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer M, Gage FH. 2017. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. Cell Stem Cell. 21(5), 618–634.e7.","chicago":"Toda, Tomohisa, Jonathan Y. Hsu, Sara B. Linker, Lauren Hu, Simon T. Schafer, Jerome Mertens, Filipe V. Jacinto, Martin Hetzer, and Fred H. Gage. “Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.” <i>Cell Stem Cell</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">https://doi.org/10.1016/j.stem.2017.08.012</a>.","ieee":"T. Toda <i>et al.</i>, “Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells,” <i>Cell Stem Cell</i>, vol. 21, no. 5. Elsevier, p. 618–634.e7, 2017.","apa":"Toda, T., Hsu, J. Y., Linker, S. B., Hu, L., Schafer, S. T., Mertens, J., … Gage, F. H. (2017). Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. <i>Cell Stem Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">https://doi.org/10.1016/j.stem.2017.08.012</a>"},"date_updated":"2022-07-18T08:33:07Z","abstract":[{"text":"Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors is unclear. Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neuronal differentiation. Genome-wide analyses show that Nup153 and Sox2 bind and co-regulate hundreds of genes. Binding of Nup153 to gene promoters or transcriptional end sites correlates with increased or decreased gene expression, respectively, and inhibiting Nup153 expression alters open chromatin configurations at its target genes, disrupts genomic localization of Sox2, and promotes differentiation in vitro and a gliogenic fate switch in vivo. Together, these findings reveal that nuclear structural proteins may exert bimodal transcriptional effects to control cell fate.","lang":"eng"}],"language":[{"iso":"eng"}],"oa":1,"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","keyword":["Cell Biology","Genetics","Molecular Medicine"],"type":"journal_article","volume":21},{"pubrep_id":"868","publication_status":"published","date_published":"2017-04-14T00:00:00Z","status":"public","month":"04","year":"2017","author":[{"full_name":"Breuss, Martin","last_name":"Breuss","first_name":"Martin"},{"last_name":"Hansen","first_name":"Andi H","full_name":"Hansen, Andi H","id":"38853E16-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Landler, Lukas","first_name":"Lukas","last_name":"Landler"},{"full_name":"Keays, David","last_name":"Keays","first_name":"David"}],"intvolume":"       323","publication_identifier":{"issn":["01664328"]},"publist_id":"6262","date_created":"2018-12-11T11:50:11Z","isi":1,"external_id":{"isi":["000397369100007"]},"file_date_updated":"2018-12-12T10:12:03Z","doi":"10.1016/j.bbr.2017.01.029","oa_version":"Published Version","ddc":["570","571"],"file":[{"relation":"main_file","date_created":"2018-12-12T10:12:03Z","date_updated":"2018-12-12T10:12:03Z","file_name":"IST-2017-868-v1+1_1-s2.0-S0166432816309160-main.pdf","access_level":"open_access","file_size":2291511,"creator":"system","file_id":"4921","content_type":"application/pdf"}],"title":"Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition","quality_controlled":"1","article_processing_charge":"No","publication":"Behavioural Brain Research","acknowledgement":"Austrian Science Fund (FWF) for funding this research [I914,P21092]","page":"47 - 55","_id":"1107","extern":"1","day":"14","publisher":"Elsevier","citation":{"ista":"Breuss M, Hansen AH, Landler L, Keays D. 2017. Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. Behavioural Brain Research. 323, 47–55.","apa":"Breuss, M., Hansen, A. H., Landler, L., &#38; Keays, D. (2017). Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. <i>Behavioural Brain Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">https://doi.org/10.1016/j.bbr.2017.01.029</a>","ieee":"M. Breuss, A. H. Hansen, L. Landler, and D. Keays, “Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition,” <i>Behavioural Brain Research</i>, vol. 323. Elsevier, pp. 47–55, 2017.","chicago":"Breuss, Martin, Andi H Hansen, Lukas Landler, and David Keays. “Brain Specific Knockin of the Pathogenic Tubb5 E401K Allele Causes Defects in Motor Coordination and Prepulse Inhibition.” <i>Behavioural Brain Research</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">https://doi.org/10.1016/j.bbr.2017.01.029</a>.","short":"M. Breuss, A.H. Hansen, L. Landler, D. Keays, Behavioural Brain Research 323 (2017) 47–55.","ama":"Breuss M, Hansen AH, Landler L, Keays D. Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. <i>Behavioural Brain Research</i>. 2017;323:47-55. doi:<a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">10.1016/j.bbr.2017.01.029</a>","mla":"Breuss, Martin, et al. “Brain Specific Knockin of the Pathogenic Tubb5 E401K Allele Causes Defects in Motor Coordination and Prepulse Inhibition.” <i>Behavioural Brain Research</i>, vol. 323, Elsevier, 2017, pp. 47–55, doi:<a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">10.1016/j.bbr.2017.01.029</a>."},"tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"has_accepted_license":"1","type":"journal_article","volume":323,"oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","abstract":[{"text":"The generation, migration, and differentiation of neurons requires the functional integrity of the microtubule cytoskeleton. Mutations in the tubulin gene family are known to cause various neurological diseases including lissencephaly, ocular motor disorders, polymicrogyria and amyotrophic lateral sclerosis. We have previously reported that mutations in TUBB5 cause microcephaly that is accompanied by severe intellectual impairment and motor delay. Here we present the characterization of a Tubb5 mouse model that allows for the conditional expression of the pathogenic E401K mutation. Homozygous knockin animals exhibit a severe reduction in brain size and in body weight. These animals do not show any significant impairment in general activity, anxiety, or in the acoustic startle response, however, present with notable defects in motor coordination. When assessed on the static rod apparatus mice took longer to orient and often lost their balance completely. Interestingly, mutant animals also showed defects in prepulse inhibition, a phenotype associated with sensorimotor gating and considered an endophenotype for schizophrenia. This study provides insight into the behavioral consequences of tubulin gene mutations.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2023-09-20T11:37:25Z"},{"date_created":"2018-12-11T11:50:11Z","isi":1,"author":[{"last_name":"Zimin","first_name":"Alexander","full_name":"Zimin, Alexander","id":"37099E9C-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-8622-7887","full_name":"Lampert, Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph","last_name":"Lampert"}],"publist_id":"6261","intvolume":"        54","year":"2017","status":"public","month":"04","ec_funded":1,"main_file_link":[{"url":"http://proceedings.mlr.press/v54/zimin17a/zimin17a.pdf","open_access":"1"}],"date_published":"2017-04-01T00:00:00Z","publication_status":"published","department":[{"_id":"ChLa"}],"article_processing_charge":"No","alternative_title":["PMLR"],"title":"Learning theory for conditional risk minimization","quality_controlled":"1","oa_version":"Submitted Version","external_id":{"isi":["000509368500024"]},"day":"01","publisher":"ML Research Press","_id":"1108","page":"213 - 222","date_updated":"2025-04-15T07:10:22Z","abstract":[{"text":"In this work we study the learnability of stochastic processes with respect to the conditional risk, i.e. the existence of a learning algorithm that improves its next-step performance with the amount of observed data. We introduce a notion of pairwise discrepancy between conditional distributions at different times steps and show how certain properties of these discrepancies can be used to construct a successful learning algorithm. Our main results are two theorems that establish criteria for learnability for many classes of stochastic processes, including all special cases studied previously in the literature.","lang":"eng"}],"language":[{"iso":"eng"}],"oa":1,"project":[{"name":"Lifelong Learning of Visual Scene Understanding","call_identifier":"FP7","grant_number":"308036","_id":"2532554C-B435-11E9-9278-68D0E5697425"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":54,"type":"conference","conference":{"start_date":"2017-04-20","location":"Fort Lauderdale, FL, United States","name":"AISTATS: Artificial Intelligence and Statistics","end_date":"2017-04-22"},"citation":{"mla":"Zimin, Alexander, and Christoph Lampert. <i>Learning Theory for Conditional Risk Minimization</i>. Vol. 54, ML Research Press, 2017, pp. 213–22.","ama":"Zimin A, Lampert C. Learning theory for conditional risk minimization. In: Vol 54. ML Research Press; 2017:213-222.","short":"A. Zimin, C. Lampert, in:, ML Research Press, 2017, pp. 213–222.","ieee":"A. Zimin and C. Lampert, “Learning theory for conditional risk minimization,” presented at the AISTATS: Artificial Intelligence and Statistics, Fort Lauderdale, FL, United States, 2017, vol. 54, pp. 213–222.","chicago":"Zimin, Alexander, and Christoph Lampert. “Learning Theory for Conditional Risk Minimization,” 54:213–22. ML Research Press, 2017.","apa":"Zimin, A., &#38; Lampert, C. (2017). Learning theory for conditional risk minimization (Vol. 54, pp. 213–222). Presented at the AISTATS: Artificial Intelligence and Statistics, Fort Lauderdale, FL, United States: ML Research Press.","ista":"Zimin A, Lampert C. 2017. Learning theory for conditional risk minimization. AISTATS: Artificial Intelligence and Statistics, PMLR, vol. 54, 213–222."}},{"doi":"10.1103/PhysRevLett.118.203203","external_id":{"arxiv":["1702.01977"],"isi":["000401664000005"]},"oa_version":"Preprint","scopus_import":"1","quality_controlled":"1","title":"Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free","article_processing_charge":"No","publication":"Physical Review Letters","publication_status":"published","department":[{"_id":"MiLe"}],"date_published":"2017-05-19T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1702.01977"}],"year":"2017","month":"05","status":"public","arxiv":1,"isi":1,"date_created":"2018-12-11T11:50:12Z","intvolume":"       118","publist_id":"6260","author":[{"first_name":"Benjamin","last_name":"Shepperson","full_name":"Shepperson, Benjamin"},{"full_name":"Søndergaard, Anders","first_name":"Anders","last_name":"Søndergaard"},{"full_name":"Christiansen, Lars","first_name":"Lars","last_name":"Christiansen"},{"last_name":"Kaczmarczyk","first_name":"Jan","full_name":"Kaczmarczyk, Jan","id":"46C405DE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1629-3675"},{"full_name":"Zillich, Robert","last_name":"Zillich","first_name":"Robert"},{"orcid":"0000-0002-6990-7802","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail","last_name":"Lemeshko"},{"full_name":"Stapelfeldt, Henrik","last_name":"Stapelfeldt","first_name":"Henrik"}],"citation":{"mla":"Shepperson, Benjamin, et al. “Laser-Induced Rotation of Iodine Molecules in Helium Nanodroplets: Revivals and Breaking-Free.” <i>Physical Review Letters</i>, vol. 118, no. 20, 203203, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.203203\">10.1103/PhysRevLett.118.203203</a>.","short":"B. Shepperson, A. Søndergaard, L. Christiansen, J. Kaczmarczyk, R. Zillich, M. Lemeshko, H. Stapelfeldt, Physical Review Letters 118 (2017).","ama":"Shepperson B, Søndergaard A, Christiansen L, et al. Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free. <i>Physical Review Letters</i>. 2017;118(20). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.203203\">10.1103/PhysRevLett.118.203203</a>","apa":"Shepperson, B., Søndergaard, A., Christiansen, L., Kaczmarczyk, J., Zillich, R., Lemeshko, M., &#38; Stapelfeldt, H. (2017). Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.118.203203\">https://doi.org/10.1103/PhysRevLett.118.203203</a>","ieee":"B. Shepperson <i>et al.</i>, “Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free,” <i>Physical Review Letters</i>, vol. 118, no. 20. American Physical Society, 2017.","chicago":"Shepperson, Benjamin, Anders Søndergaard, Lars Christiansen, Jan Kaczmarczyk, Robert Zillich, Mikhail Lemeshko, and Henrik Stapelfeldt. “Laser-Induced Rotation of Iodine Molecules in Helium Nanodroplets: Revivals and Breaking-Free.” <i>Physical Review Letters</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevLett.118.203203\">https://doi.org/10.1103/PhysRevLett.118.203203</a>.","ista":"Shepperson B, Søndergaard A, Christiansen L, Kaczmarczyk J, Zillich R, Lemeshko M, Stapelfeldt H. 2017. Laser-induced rotation of iodine molecules in helium nanodroplets: Revivals and breaking-free. Physical Review Letters. 118(20), 203203."},"article_number":"203203","issue":"20","project":[{"call_identifier":"FWF","grant_number":"P29902","_id":"26031614-B435-11E9-9278-68D0E5697425","name":"Quantum rotations in the presence of a many-body environment"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"volume":118,"type":"journal_article","date_updated":"2025-06-04T08:36:27Z","language":[{"iso":"eng"}],"abstract":[{"text":"Rotation of molecules embedded in He nanodroplets is explored by a combination of fs laser-induced alignment experiments and angulon quasiparticle theory. We demonstrate that at low fluence of the fs alignment pulse, the molecule and its solvation shell can be set into coherent collective rotation lasting long enough to form revivals. With increasing fluence, however, the revivals disappear -- instead, rotational dynamics as rapid as for an isolated molecule is observed during the first few picoseconds. Classical calculations trace this phenomenon to transient decoupling of the molecule from its He shell. Our results open novel opportunities for studying non-equilibrium solute-solvent dynamics and quantum thermalization. ","lang":"eng"}],"_id":"1109","day":"19","publisher":"American Physical Society"},{"type":"journal_article","volume":7,"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"call_identifier":"FP7","grant_number":"282300","_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants"}],"abstract":[{"lang":"eng","text":"The phytohormone auxin is a major determinant and regulatory component important for plant development. Auxin transport between cells is mediated by a complex system of transporters such as AUX1/LAX, PIN, and ABCB proteins, and their localization and activity is thought to be influenced by phosphatases and kinases. Flavonols have been shown to alter auxin transport activity and changes in flavonol accumulation in the Arabidopsis thaliana rol1-2 mutant cause defects in auxin transport and seedling development. A new mutation in ROOTS CURL IN NPA 1 (RCN1), encoding a regulatory subunit of the phosphatase PP2A, was found to suppress the growth defects of rol1-2 without changing the flavonol content. rol1-2 rcn1-3 double mutants show wild type-like auxin transport activity while levels of free auxin are not affected by rcn1-3. In the rol1-2 mutant, PIN2 shows a flavonol-induced basal-to-apical shift in polar localization which is reversed in the rol1-2 rcn1-3 to basal localization. In vivo analysis of PINOID action, a kinase known to influence PIN protein localization in a PP2A-antagonistic manner, revealed a negative impact of flavonols on PINOID activity. Together, these data suggest that flavonols affect auxin transport by modifying the antagonistic kinase/phosphatase equilibrium."}],"language":[{"iso":"eng"}],"date_updated":"2025-07-10T11:50:06Z","citation":{"ama":"Kuhn B, Nodzyński T, Errafi S, et al. Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity. <i>Scientific Reports</i>. 2017;7. doi:<a href=\"https://doi.org/10.1038/srep41906\">10.1038/srep41906</a>","short":"B. Kuhn, T. Nodzyński, S. Errafi, R. Bucher, S. Gupta, B. Aryal, P. Dobrev, L. Bigler, M. Geisler, E. Zažímalová, J. Friml, C. Ringli, Scientific Reports 7 (2017).","mla":"Kuhn, Benjamin, et al. “Flavonol-Induced Changes in PIN2 Polarity and Auxin Transport in the Arabidopsis Thaliana Rol1-2 Mutant Require Phosphatase Activity.” <i>Scientific Reports</i>, vol. 7, 41906, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/srep41906\">10.1038/srep41906</a>.","ista":"Kuhn B, Nodzyński T, Errafi S, Bucher R, Gupta S, Aryal B, Dobrev P, Bigler L, Geisler M, Zažímalová E, Friml J, Ringli C. 2017. Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity. Scientific Reports. 7, 41906.","ieee":"B. Kuhn <i>et al.</i>, “Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity,” <i>Scientific Reports</i>, vol. 7. Nature Publishing Group, 2017.","chicago":"Kuhn, Benjamin, Tomasz Nodzyński, Sanae Errafi, Rahel Bucher, Shibu Gupta, Bibek Aryal, Petre Dobrev, et al. “Flavonol-Induced Changes in PIN2 Polarity and Auxin Transport in the Arabidopsis Thaliana Rol1-2 Mutant Require Phosphatase Activity.” <i>Scientific Reports</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/srep41906\">https://doi.org/10.1038/srep41906</a>.","apa":"Kuhn, B., Nodzyński, T., Errafi, S., Bucher, R., Gupta, S., Aryal, B., … Ringli, C. (2017). Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity. <i>Scientific Reports</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/srep41906\">https://doi.org/10.1038/srep41906</a>"},"has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_number":"41906","_id":"1110","day":"06","publisher":"Nature Publishing Group","article_processing_charge":"No","publication":"Scientific Reports","acknowledgement":"European Research Council (project ERC-2011-StG-20101109-PSDP), European Social Fund (CZ.1.07/2.3.00/20.0043) and the Czech Science Foundation (GA13-40637S) [JF].","oa_version":"Published Version","doi":"10.1038/srep41906","file_date_updated":"2018-12-12T10:18:09Z","external_id":{"isi":["000393367600001"]},"ddc":["581"],"file":[{"relation":"main_file","content_type":"application/pdf","creator":"system","file_id":"5328","file_size":1654496,"access_level":"open_access","file_name":"IST-2017-803-v1+1_srep41906.pdf","date_created":"2018-12-12T10:18:09Z","date_updated":"2018-12-12T10:18:09Z"}],"title":"Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity","quality_controlled":"1","scopus_import":"1","status":"public","month":"02","year":"2017","author":[{"first_name":"Benjamin","last_name":"Kuhn","full_name":"Kuhn, Benjamin"},{"full_name":"Nodzyński, Tomasz","last_name":"Nodzyński","first_name":"Tomasz"},{"full_name":"Errafi, Sanae","first_name":"Sanae","last_name":"Errafi"},{"last_name":"Bucher","first_name":"Rahel","full_name":"Bucher, Rahel"},{"last_name":"Gupta","first_name":"Shibu","full_name":"Gupta, Shibu"},{"first_name":"Bibek","last_name":"Aryal","full_name":"Aryal, Bibek"},{"first_name":"Petre","last_name":"Dobrev","full_name":"Dobrev, Petre"},{"full_name":"Bigler, Laurent","first_name":"Laurent","last_name":"Bigler"},{"first_name":"Markus","last_name":"Geisler","full_name":"Geisler, Markus"},{"full_name":"Zažímalová, Eva","last_name":"Zažímalová","first_name":"Eva"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jirí"},{"first_name":"Christoph","last_name":"Ringli","full_name":"Ringli, Christoph"}],"publication_identifier":{"issn":["2045-2322"]},"publist_id":"6258","intvolume":"         7","date_created":"2018-12-11T11:50:12Z","isi":1,"pubrep_id":"803","department":[{"_id":"JiFr"}],"publication_status":"published","ec_funded":1,"date_published":"2017-02-06T00:00:00Z"},{"citation":{"short":"J. Heredia, B. Trubenova, D. Sudholt, T. Paixao, Genetics 205 (2017) 803–825.","ama":"Heredia J, Trubenova B, Sudholt D, Paixao T. Selection limits to adaptive walks on correlated landscapes. <i>Genetics</i>. 2017;205(2):803-825. doi:<a href=\"https://doi.org/10.1534/genetics.116.189340\">10.1534/genetics.116.189340</a>","mla":"Heredia, Jorge, et al. “Selection Limits to Adaptive Walks on Correlated Landscapes.” <i>Genetics</i>, vol. 205, no. 2, Genetics Society of America, 2017, pp. 803–25, doi:<a href=\"https://doi.org/10.1534/genetics.116.189340\">10.1534/genetics.116.189340</a>.","ista":"Heredia J, Trubenova B, Sudholt D, Paixao T. 2017. Selection limits to adaptive walks on correlated landscapes. Genetics. 205(2), 803–825.","apa":"Heredia, J., Trubenova, B., Sudholt, D., &#38; Paixao, T. (2017). Selection limits to adaptive walks on correlated landscapes. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.116.189340\">https://doi.org/10.1534/genetics.116.189340</a>","ieee":"J. Heredia, B. Trubenova, D. Sudholt, and T. Paixao, “Selection limits to adaptive walks on correlated landscapes,” <i>Genetics</i>, vol. 205, no. 2. Genetics Society of America, pp. 803–825, 2017.","chicago":"Heredia, Jorge, Barbora Trubenova, Dirk Sudholt, and Tiago Paixao. “Selection Limits to Adaptive Walks on Correlated Landscapes.” <i>Genetics</i>. Genetics Society of America, 2017. <a href=\"https://doi.org/10.1534/genetics.116.189340\">https://doi.org/10.1534/genetics.116.189340</a>."},"issue":"2","type":"journal_article","volume":205,"oa":1,"project":[{"name":"Speed of Adaptation in Population Genetics and Evolutionary Computation","call_identifier":"FP7","_id":"25B1EC9E-B435-11E9-9278-68D0E5697425","grant_number":"618091"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Adaptation depends critically on the effects of new mutations and their dependency on the genetic background in which they occur. These two factors can be summarized by the fitness landscape. However, it would require testing all mutations in all backgrounds, making the definition and analysis of fitness landscapes mostly inaccessible. Instead of postulating a particular fitness landscape, we address this problem by considering general classes of landscapes and calculating an upper limit for the time it takes for a population to reach a fitness peak, circumventing the need to have full knowledge about the fitness landscape. We analyze populations in the weak-mutation regime and characterize the conditions that enable them to quickly reach the fitness peak as a function of the number of sites under selection. We show that for additive landscapes there is a critical selection strength enabling populations to reach high-fitness genotypes, regardless of the distribution of effects. This threshold scales with the number of sites under selection, effectively setting a limit to adaptation, and results from the inevitable increase in deleterious mutational pressure as the population adapts in a space of discrete genotypes. Furthermore, we show that for the class of all unimodal landscapes this condition is sufficient but not necessary for rapid adaptation, as in some highly epistatic landscapes the critical strength does not depend on the number of sites under selection; effectively removing this barrier to adaptation."}],"language":[{"iso":"eng"}],"date_updated":"2025-07-10T11:50:06Z","page":"803 - 825","_id":"1111","article_type":"original","day":"01","publisher":"Genetics Society of America","doi":"10.1534/genetics.116.189340","oa_version":"Published Version","external_id":{"isi":["000394144900025"],"pmid":["27881471"]},"title":"Selection limits to adaptive walks on correlated landscapes","quality_controlled":"1","scopus_import":"1","article_processing_charge":"No","pmid":1,"publication":"Genetics","department":[{"_id":"NiBa"}],"publication_status":"published","ec_funded":1,"date_published":"2017-02-01T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1534/genetics.116.189340"}],"status":"public","month":"02","year":"2017","author":[{"full_name":"Heredia, Jorge","first_name":"Jorge","last_name":"Heredia"},{"orcid":"0000-0002-6873-2967","full_name":"Trubenova, Barbora","id":"42302D54-F248-11E8-B48F-1D18A9856A87","first_name":"Barbora","last_name":"Trubenova"},{"full_name":"Sudholt, Dirk","first_name":"Dirk","last_name":"Sudholt"},{"orcid":"0000-0003-2361-3953","full_name":"Paixao, Tiago","id":"2C5658E6-F248-11E8-B48F-1D18A9856A87","first_name":"Tiago","last_name":"Paixao"}],"publication_identifier":{"issn":["0016-6731"]},"publist_id":"6256","intvolume":"       205","date_created":"2018-12-11T11:50:12Z","isi":1},{"oa_version":"None","citation":{"ama":"Paixao T, Pérez Heredia J. An application of stochastic differential equations to evolutionary algorithms. In: <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i>. ACM; 2017:3-11. doi:<a href=\"https://doi.org/10.1145/3040718.3040729\">10.1145/3040718.3040729</a>","short":"T. Paixao, J. Pérez Heredia, in:, Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms, ACM, 2017, pp. 3–11.","mla":"Paixao, Tiago, and Jorge Pérez Heredia. “An Application of Stochastic Differential Equations to Evolutionary Algorithms.” <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i>, ACM, 2017, pp. 3–11, doi:<a href=\"https://doi.org/10.1145/3040718.3040729\">10.1145/3040718.3040729</a>.","ista":"Paixao T, Pérez Heredia J. 2017. An application of stochastic differential equations to evolutionary algorithms. Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms. FOGA: Foundations of Genetic Algorithms, 3–11.","ieee":"T. Paixao and J. Pérez Heredia, “An application of stochastic differential equations to evolutionary algorithms,” in <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i>, Copenhagen, Denmark, 2017, pp. 3–11.","chicago":"Paixao, Tiago, and Jorge Pérez Heredia. “An Application of Stochastic Differential Equations to Evolutionary Algorithms.” In <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i>, 3–11. ACM, 2017. <a href=\"https://doi.org/10.1145/3040718.3040729\">https://doi.org/10.1145/3040718.3040729</a>.","apa":"Paixao, T., &#38; Pérez Heredia, J. (2017). An application of stochastic differential equations to evolutionary algorithms. In <i>Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms</i> (pp. 3–11). Copenhagen, Denmark: ACM. <a href=\"https://doi.org/10.1145/3040718.3040729\">https://doi.org/10.1145/3040718.3040729</a>"},"doi":"10.1145/3040718.3040729","scopus_import":1,"conference":{"start_date":"2017-01-12","location":"Copenhagen, Denmark","end_date":"2017-01-15","name":"FOGA: Foundations of Genetic Algorithms"},"title":"An application of stochastic differential equations to evolutionary algorithms","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","date_updated":"2021-01-12T06:48:22Z","abstract":[{"lang":"eng","text":"There has been renewed interest in modelling the behaviour of evolutionary algorithms by more traditional mathematical objects, such as ordinary differential equations or Markov chains. The advantage is that the analysis becomes greatly facilitated due to the existence of well established methods. However, this typically comes at the cost of disregarding information about the process. Here, we introduce the use of stochastic differential equations (SDEs) for the study of EAs. SDEs can produce simple analytical results for the dynamics of stochastic processes, unlike Markov chains which can produce rigorous but unwieldy expressions about the dynamics. On the other hand, unlike ordinary differential equations (ODEs), they do not discard information about the stochasticity of the process. We show that these are especially suitable for the analysis of fixed budget scenarios and present analogs of the additive and multiplicative drift theorems for SDEs. We exemplify the use of these methods for two model algorithms ((1+1) EA and RLS) on two canonical problems(OneMax and LeadingOnes)."}],"publication":"Proceedings of the 14th ACM/SIGEVO Conference on Foundations of Genetic Algorithms","language":[{"iso":"eng"}],"publication_status":"published","page":"3 - 11","department":[{"_id":"NiBa"}],"date_published":"2017-01-12T00:00:00Z","year":"2017","status":"public","month":"01","_id":"1112","date_created":"2018-12-11T11:50:12Z","publisher":"ACM","day":"12","author":[{"last_name":"Paixao","first_name":"Tiago","id":"2C5658E6-F248-11E8-B48F-1D18A9856A87","full_name":"Paixao, Tiago","orcid":"0000-0003-2361-3953"},{"full_name":"Pérez Heredia, Jorge","last_name":"Pérez Heredia","first_name":"Jorge"}],"publication_identifier":{"isbn":["978-145034651-1"]},"publist_id":"6255"},{"_id":"1113","article_type":"original","related_material":{"record":[{"relation":"earlier_version","status":"public","id":"1164"},{"status":"public","id":"1595","relation":"earlier_version"}]},"publisher":"Brown University","day":"01","page":"135 - 154","type":"journal_article","volume":21,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"oa":1,"language":[{"iso":"eng"}],"abstract":[{"text":"A drawing of a graph G is radial if the vertices of G are placed on concentric circles C 1 , . . . , C k with common center c , and edges are drawn radially : every edge intersects every circle centered at c at most once. G is radial planar if it has a radial embedding, that is, a crossing-free radial drawing. If the vertices of G are ordered or partitioned into ordered levels (as they are for leveled graphs), we require that the assignment of vertices to circles corresponds to the given ordering or leveling. We show that a graph G is radial planar if G has a radial drawing in which every two edges cross an even number of times; the radial embedding has the same leveling as the radial drawing. In other words, we establish the weak variant of the Hanani-Tutte theorem for radial planarity. This generalizes a result by Pach and Toth.","lang":"eng"}],"date_updated":"2025-09-23T09:13:42Z","citation":{"apa":"Fulek, R., Pelsmajer, M., &#38; Schaefer, M. (2017). Hanani-Tutte for radial planarity. <i>Journal of Graph Algorithms and Applications</i>. Brown University. <a href=\"https://doi.org/10.7155/jgaa.00408\">https://doi.org/10.7155/jgaa.00408</a>","chicago":"Fulek, Radoslav, Michael Pelsmajer, and Marcus Schaefer. “Hanani-Tutte for Radial Planarity.” <i>Journal of Graph Algorithms and Applications</i>. Brown University, 2017. <a href=\"https://doi.org/10.7155/jgaa.00408\">https://doi.org/10.7155/jgaa.00408</a>.","ieee":"R. Fulek, M. Pelsmajer, and M. Schaefer, “Hanani-Tutte for radial planarity,” <i>Journal of Graph Algorithms and Applications</i>, vol. 21, no. 1. Brown University, pp. 135–154, 2017.","ista":"Fulek R, Pelsmajer M, Schaefer M. 2017. Hanani-Tutte for radial planarity. Journal of Graph Algorithms and Applications. 21(1), 135–154.","mla":"Fulek, Radoslav, et al. “Hanani-Tutte for Radial Planarity.” <i>Journal of Graph Algorithms and Applications</i>, vol. 21, no. 1, Brown University, 2017, pp. 135–54, doi:<a href=\"https://doi.org/10.7155/jgaa.00408\">10.7155/jgaa.00408</a>.","short":"R. Fulek, M. Pelsmajer, M. Schaefer, Journal of Graph Algorithms and Applications 21 (2017) 135–154.","ama":"Fulek R, Pelsmajer M, Schaefer M. Hanani-Tutte for radial planarity. <i>Journal of Graph Algorithms and Applications</i>. 2017;21(1):135-154. doi:<a href=\"https://doi.org/10.7155/jgaa.00408\">10.7155/jgaa.00408</a>"},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","issue":"1","month":"01","status":"public","year":"2017","intvolume":"        21","publist_id":"6254","author":[{"last_name":"Fulek","first_name":"Radoslav","id":"39F3FFE4-F248-11E8-B48F-1D18A9856A87","full_name":"Fulek, Radoslav","orcid":"0000-0001-8485-1774"},{"last_name":"Pelsmajer","first_name":"Michael","full_name":"Pelsmajer, Michael"},{"first_name":"Marcus","last_name":"Schaefer","full_name":"Schaefer, Marcus"}],"arxiv":1,"date_created":"2018-12-11T11:50:13Z","department":[{"_id":"UlWa"}],"publication_status":"published","date_published":"2017-01-01T00:00:00Z","ec_funded":1,"article_processing_charge":"No","publication":"Journal of Graph Algorithms and Applications","acknowledgement":"An earlier version of the paper appeared in the proceedings of Graph Drawing 2015.  The research of the first author has received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no [291734].","ddc":["510"],"external_id":{"arxiv":["1608.08662"]},"doi":"10.7155/jgaa.00408","file_date_updated":"2019-10-24T10:54:37Z","oa_version":"Published Version","file":[{"relation":"main_file","file_id":"6967","creator":"dernst","content_type":"application/pdf","success":1,"file_size":573623,"access_level":"open_access","file_name":"2017_JournalGraphAlgorithms_Fulek.pdf","date_updated":"2019-10-24T10:54:37Z","date_created":"2019-10-24T10:54:37Z"}],"quality_controlled":"1","title":"Hanani-Tutte for radial planarity","scopus_import":"1"},{"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","volume":7,"date_updated":"2025-07-10T11:50:07Z","abstract":[{"lang":"eng","text":"Nonequilibrium phase transitions exist in damped-driven open quantum systems when the continuous tuning of an external parameter leads to a transition between two robust steady states. In second-order transitions this change is abrupt at a critical point, whereas in first-order transitions the two phases can coexist in a critical hysteresis domain. Here, we report the observation of a first-order dissipative quantum phase transition in a driven circuit quantum electrodynamics system. It takes place when the photon blockade of the driven cavity-atom system is broken by increasing the drive power. The observed experimental signature is a bimodal phase space distribution with varying weights controlled by the drive strength. Our measurements show an improved stabilization of the classical attractors up to the millisecond range when the size of the quantum system is increased from one to three artificial atoms. The formation of such robust pointer states could be used for new quantum measurement schemes or to investigate multiphoton phases of finite-size, nonlinear, open quantum systems."}],"language":[{"iso":"eng"}],"citation":{"mla":"Fink, Johannes M., et al. “Observation of the Photon Blockade Breakdown Phase Transition.” <i>Physical Review X</i>, vol. 7, no. 1, 011012, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevX.7.011012\">10.1103/PhysRevX.7.011012</a>.","ama":"Fink JM, Dombi A, Vukics A, Wallraff A, Domokos P. Observation of the photon blockade breakdown phase transition. <i>Physical Review X</i>. 2017;7(1). doi:<a href=\"https://doi.org/10.1103/PhysRevX.7.011012\">10.1103/PhysRevX.7.011012</a>","short":"J.M. Fink, A. Dombi, A. Vukics, A. Wallraff, P. Domokos, Physical Review X 7 (2017).","ieee":"J. M. Fink, A. Dombi, A. Vukics, A. Wallraff, and P. Domokos, “Observation of the photon blockade breakdown phase transition,” <i>Physical Review X</i>, vol. 7, no. 1. American Physical Society, 2017.","chicago":"Fink, Johannes M, András Dombi, András Vukics, Andreas Wallraff, and Peter Domokos. “Observation of the Photon Blockade Breakdown Phase Transition.” <i>Physical Review X</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevX.7.011012\">https://doi.org/10.1103/PhysRevX.7.011012</a>.","apa":"Fink, J. M., Dombi, A., Vukics, A., Wallraff, A., &#38; Domokos, P. (2017). Observation of the photon blockade breakdown phase transition. <i>Physical Review X</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevX.7.011012\">https://doi.org/10.1103/PhysRevX.7.011012</a>","ista":"Fink JM, Dombi A, Vukics A, Wallraff A, Domokos P. 2017. Observation of the photon blockade breakdown phase transition. Physical Review X. 7(1), 011012."},"issue":"1","article_number":"011012","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"_id":"1114","publisher":"American Physical Society","day":"31","article_processing_charge":"Yes","publication":"Physical Review X","file":[{"relation":"main_file","file_size":1172926,"creator":"system","file_id":"4972","content_type":"application/pdf","date_created":"2018-12-12T10:12:52Z","date_updated":"2018-12-12T10:12:52Z","file_name":"IST-2017-753-v1+1_PhysRevX.7.011012.pdf","access_level":"open_access"}],"external_id":{"isi":["000397450500001"]},"oa_version":"Published Version","file_date_updated":"2018-12-12T10:12:52Z","doi":"10.1103/PhysRevX.7.011012","ddc":["539"],"scopus_import":"1","title":"Observation of the photon blockade breakdown phase transition","quality_controlled":"1","year":"2017","status":"public","month":"01","date_created":"2018-12-11T11:50:13Z","isi":1,"author":[{"first_name":"Johannes M","last_name":"Fink","orcid":"0000-0001-8112-028X","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"András","last_name":"Dombi","full_name":"Dombi, András"},{"full_name":"Vukics, András","last_name":"Vukics","first_name":"András"},{"last_name":"Wallraff","first_name":"Andreas","full_name":"Wallraff, Andreas"},{"last_name":"Domokos","first_name":"Peter","full_name":"Domokos, Peter"}],"intvolume":"         7","publication_identifier":{"issn":["2160-3308"]},"publist_id":"6252","publication_status":"published","pubrep_id":"753","department":[{"_id":"JoFi"}],"date_published":"2017-01-31T00:00:00Z"},{"volume":93,"type":"journal_article","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","project":[{"name":"Mechanisms of transmitter release at GABAergic synapses","_id":"25C26B1E-B435-11E9-9278-68D0E5697425","grant_number":"P24909-B24","call_identifier":"FWF"},{"call_identifier":"FP7","grant_number":"268548","_id":"25C0F108-B435-11E9-9278-68D0E5697425","name":"Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons"}],"oa":1,"language":[{"iso":"eng"}],"abstract":[{"text":"Sharp wave-ripple (SWR) oscillations play a key role in memory consolidation during non-rapid eye movement sleep, immobility, and consummatory behavior. However, whether temporally modulated synaptic excitation or inhibition underlies the ripples is controversial. To address this question, we performed simultaneous recordings of excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) and local field potentials (LFPs) in the CA1 region of awake mice in vivo. During SWRs, inhibition dominated over excitation, with a peak conductance ratio of 4.1 ± 0.5. Furthermore, the amplitude of SWR-associated IPSCs was positively correlated with SWR magnitude, whereas that of EPSCs was not. Finally, phase analysis indicated that IPSCs were phase-locked to individual ripple cycles, whereas EPSCs were uniformly distributed in phase space. Optogenetic inhibition indicated that PV+ interneurons provided a major contribution to SWR-associated IPSCs. Thus, phasic inhibition, but not excitation, shapes SWR oscillations in the hippocampal CA1 region in vivo.","lang":"eng"}],"date_updated":"2025-04-15T07:20:01Z","citation":{"ista":"Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. 2017. Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo. Neuron. 93(2), 308–314.","ieee":"J. Gan, S.-M. Weng, A. Pernia-Andrade, J. L. Csicsvari, and P. M. Jonas, “Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo,” <i>Neuron</i>, vol. 93, no. 2. Elsevier, pp. 308–314, 2017.","chicago":"Gan, Jian, Shih-Ming Weng, Alejandro Pernia-Andrade, Jozsef L Csicsvari, and Peter M Jonas. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice in Vivo.” <i>Neuron</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.neuron.2016.12.018\">https://doi.org/10.1016/j.neuron.2016.12.018</a>.","apa":"Gan, J., Weng, S.-M., Pernia-Andrade, A., Csicsvari, J. L., &#38; Jonas, P. M. (2017). Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2016.12.018\">https://doi.org/10.1016/j.neuron.2016.12.018</a>","ama":"Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo. <i>Neuron</i>. 2017;93(2):308-314. doi:<a href=\"https://doi.org/10.1016/j.neuron.2016.12.018\">10.1016/j.neuron.2016.12.018</a>","short":"J. Gan, S.-M. Weng, A. Pernia-Andrade, J.L. Csicsvari, P.M. Jonas, Neuron 93 (2017) 308–314.","mla":"Gan, Jian, et al. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice in Vivo.” <i>Neuron</i>, vol. 93, no. 2, Elsevier, 2017, pp. 308–14, doi:<a href=\"https://doi.org/10.1016/j.neuron.2016.12.018\">10.1016/j.neuron.2016.12.018</a>."},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","issue":"2","_id":"1118","day":"18","publisher":"Elsevier","page":"308 - 314","article_processing_charge":"No","publication":"Neuron","ddc":["571"],"file_date_updated":"2018-12-12T10:08:56Z","external_id":{"isi":["000396428200010"]},"doi":"10.1016/j.neuron.2016.12.018","oa_version":"Published Version","file":[{"relation":"main_file","file_name":"IST-2017-752-v1+1_1-s2.0-S0896627316309606-main.pdf","access_level":"open_access","date_updated":"2018-12-12T10:08:56Z","date_created":"2018-12-12T10:08:56Z","creator":"system","content_type":"application/pdf","file_id":"4719","file_size":2738950}],"quality_controlled":"1","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"ScienComp"},{"_id":"PreCl"}],"title":"Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations in awake mice in vivo","scopus_import":"1","month":"01","status":"public","year":"2017","intvolume":"        93","publist_id":"6244","author":[{"first_name":"Jian","last_name":"Gan","id":"3614E438-F248-11E8-B48F-1D18A9856A87","full_name":"Gan, Jian"},{"first_name":"Shih-Ming","last_name":"Weng","id":"2F9C5AC8-F248-11E8-B48F-1D18A9856A87","full_name":"Weng, Shih-Ming"},{"id":"36963E98-F248-11E8-B48F-1D18A9856A87","full_name":"Pernia-Andrade, Alejandro","first_name":"Alejandro","last_name":"Pernia-Andrade"},{"full_name":"Csicsvari, Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","first_name":"Jozsef L"},{"full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","last_name":"Jonas","first_name":"Peter M"}],"isi":1,"date_created":"2018-12-11T11:50:15Z","department":[{"_id":"PeJo"},{"_id":"JoCs"}],"pubrep_id":"752","publication_status":"published","date_published":"2017-01-18T00:00:00Z","ec_funded":1},{"day":"27","publisher":"American Physical Society","_id":"1119","date_updated":"2025-06-04T08:36:48Z","abstract":[{"text":"Understanding the behavior of molecules interacting with superfluid helium represents a formidable challenge and, in general, requires approaches relying on large-scale numerical simulations. Here we demonstrate that experimental data collected over the last 20 years provide evidence that molecules immersed in superfluid helium form recently-predicted angulon quasiparticles [Phys. Rev. Lett. 114, 203001 (2015)]. Most importantly, casting the many-body problem in terms of angulons amounts to a drastic simplification and yields effective molecular moments of inertia as straightforward analytic solutions of a simple microscopic Hamiltonian. The outcome of the angulon theory is in good agreement with experiment for a broad range of molecular impurities, from heavy to medium-mass to light species. These results pave the way to understanding molecular rotation in liquid and crystalline phases in terms of the angulon quasiparticle.","lang":"eng"}],"language":[{"iso":"eng"}],"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"Genome-wide Analysis of Root Traits","_id":"25636330-B435-11E9-9278-68D0E5697425","grant_number":"11-NSF-1070"}],"type":"journal_article","volume":118,"issue":"9","article_number":"095301","citation":{"ista":"Lemeshko M. 2017. Quasiparticle approach to molecules interacting with quantum solvents. Physical Review Letters. 118(9), 095301.","ieee":"M. Lemeshko, “Quasiparticle approach to molecules interacting with quantum solvents,” <i>Physical Review Letters</i>, vol. 118, no. 9. American Physical Society, 2017.","chicago":"Lemeshko, Mikhail. “Quasiparticle Approach to Molecules Interacting with Quantum Solvents.” <i>Physical Review Letters</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevLett.118.095301\">https://doi.org/10.1103/PhysRevLett.118.095301</a>.","apa":"Lemeshko, M. (2017). Quasiparticle approach to molecules interacting with quantum solvents. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.118.095301\">https://doi.org/10.1103/PhysRevLett.118.095301</a>","ama":"Lemeshko M. Quasiparticle approach to molecules interacting with quantum solvents. <i>Physical Review Letters</i>. 2017;118(9). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.095301\">10.1103/PhysRevLett.118.095301</a>","short":"M. Lemeshko, Physical Review Letters 118 (2017).","mla":"Lemeshko, Mikhail. “Quasiparticle Approach to Molecules Interacting with Quantum Solvents.” <i>Physical Review Letters</i>, vol. 118, no. 9, 095301, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.095301\">10.1103/PhysRevLett.118.095301</a>."},"date_created":"2018-12-11T11:50:15Z","isi":1,"arxiv":1,"author":[{"first_name":"Mikhail","last_name":"Lemeshko","orcid":"0000-0002-6990-7802","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"6243","intvolume":"       118","publication_identifier":{"issn":["0031-9007"]},"year":"2017","status":"public","month":"02","date_published":"2017-02-27T00:00:00Z","main_file_link":[{"url":"https://arxiv.org/abs/1610.01604","open_access":"1"}],"publication_status":"published","department":[{"_id":"MiLe"}],"publication":"Physical Review Letters","article_processing_charge":"No","scopus_import":"1","title":"Quasiparticle approach to molecules interacting with quantum solvents","quality_controlled":"1","external_id":{"isi":["000404769200006"],"arxiv":["1610.01604"]},"doi":"10.1103/PhysRevLett.118.095301","oa_version":"Submitted Version"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"call_identifier":"FP7","_id":"257A4776-B435-11E9-9278-68D0E5697425","grant_number":"281511","name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex"}],"oa":1,"type":"journal_article","volume":355,"date_updated":"2025-07-10T11:50:09Z","language":[{"iso":"eng"}],"abstract":[{"text":"The hippocampus is thought to initiate systems-wide mnemonic processes through the reactivation of previously acquired spatial and episodic memory traces, which can recruit the entorhinal cortex as a first stage of memory redistribution to other brain areas. Hippocampal reactivation occurs during sharp wave-ripples, in which synchronous network firing encodes sequences of places.We investigated the coordination of this replay by recording assembly activity simultaneously in the CA1 region of the hippocampus and superficial layers of the medial entorhinal cortex. We found that entorhinal cell assemblies can replay trajectories independently of the hippocampus and sharp wave-ripples. This suggests that the hippocampus is not the sole initiator of spatial and episodic memory trace reactivation. Memory systems involved in these processes may include nonhierarchical, parallel components.","lang":"eng"}],"citation":{"ista":"O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. 2017. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. 355(6321), 184–188.","ieee":"J. O’Neill, C. N. Boccara, F. Stella, P. Schönenberger, and J. L. Csicsvari, “Superficial layers of the medial entorhinal cortex replay independently of the hippocampus,” <i>Science</i>, vol. 355, no. 6321. American Association for the Advancement of Science, pp. 184–188, 2017.","chicago":"O’Neill, Joseph, Charlotte N. Boccara, Federico Stella, Philipp Schönenberger, and Jozsef L Csicsvari. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” <i>Science</i>. American Association for the Advancement of Science, 2017. <a href=\"https://doi.org/10.1126/science.aag2787\">https://doi.org/10.1126/science.aag2787</a>.","apa":"O’Neill, J., Boccara, C. N., Stella, F., Schönenberger, P., &#38; Csicsvari, J. L. (2017). Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aag2787\">https://doi.org/10.1126/science.aag2787</a>","ama":"O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. <i>Science</i>. 2017;355(6321):184-188. doi:<a href=\"https://doi.org/10.1126/science.aag2787\">10.1126/science.aag2787</a>","short":"J. O’Neill, C.N. Boccara, F. Stella, P. Schönenberger, J.L. Csicsvari, Science 355 (2017) 184–188.","mla":"O’Neill, Joseph, et al. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” <i>Science</i>, vol. 355, no. 6321, American Association for the Advancement of Science, 2017, pp. 184–88, doi:<a href=\"https://doi.org/10.1126/science.aag2787\">10.1126/science.aag2787</a>."},"issue":"6321","has_accepted_license":"1","_id":"1132","day":"13","publisher":"American Association for the Advancement of Science","page":"184 - 188","article_processing_charge":"No","publication":"Science","file":[{"creator":"system","content_type":"application/pdf","file_id":"4809","file_size":3761201,"access_level":"open_access","file_name":"IST-2018-976-v1+1_2017Preprint_ONeill_Superficial_layers.pdf","date_created":"2018-12-12T10:10:22Z","date_updated":"2018-12-12T10:10:22Z","relation":"main_file"}],"ddc":["571"],"external_id":{"isi":["000391743700044"]},"doi":"10.1126/science.aag2787","file_date_updated":"2018-12-12T10:10:22Z","oa_version":"Submitted Version","scopus_import":"1","quality_controlled":"1","title":"Superficial layers of the medial entorhinal cortex replay independently of the hippocampus","year":"2017","month":"01","status":"public","isi":1,"date_created":"2018-12-11T11:50:19Z","intvolume":"       355","publist_id":"6226","publication_identifier":{"issn":["0036-8075"]},"author":[{"full_name":"O'Neill, Joseph","id":"426376DC-F248-11E8-B48F-1D18A9856A87","first_name":"Joseph","last_name":"O'Neill"},{"first_name":"Charlotte","last_name":"Boccara","orcid":"0000-0001-7237-5109","id":"3FC06552-F248-11E8-B48F-1D18A9856A87","full_name":"Boccara, Charlotte"},{"first_name":"Federico","last_name":"Stella","orcid":"0000-0001-9439-3148","full_name":"Stella, Federico","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Schönenberger, Philipp","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","last_name":"Schönenberger"},{"last_name":"Csicsvari","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036"}],"publication_status":"published","department":[{"_id":"JoCs"}],"pubrep_id":"976","date_published":"2017-01-13T00:00:00Z","ec_funded":1},{"article_number":"085302","issue":"8","citation":{"ista":"Yakaboylu E, Lemeshko M. 2017. Anomalous screening of quantum impurities by a neutral environment. Physical Review Letters. 118(8), 085302.","apa":"Yakaboylu, E., &#38; Lemeshko, M. (2017). Anomalous screening of quantum impurities by a neutral environment. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.118.085302\">https://doi.org/10.1103/PhysRevLett.118.085302</a>","chicago":"Yakaboylu, Enderalp, and Mikhail Lemeshko. “Anomalous Screening of Quantum Impurities by a Neutral Environment.” <i>Physical Review Letters</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevLett.118.085302\">https://doi.org/10.1103/PhysRevLett.118.085302</a>.","ieee":"E. Yakaboylu and M. Lemeshko, “Anomalous screening of quantum impurities by a neutral environment,” <i>Physical Review Letters</i>, vol. 118, no. 8. American Physical Society, 2017.","short":"E. Yakaboylu, M. Lemeshko, Physical Review Letters 118 (2017).","ama":"Yakaboylu E, Lemeshko M. Anomalous screening of quantum impurities by a neutral environment. <i>Physical Review Letters</i>. 2017;118(8). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.085302\">10.1103/PhysRevLett.118.085302</a>","mla":"Yakaboylu, Enderalp, and Mikhail Lemeshko. “Anomalous Screening of Quantum Impurities by a Neutral Environment.” <i>Physical Review Letters</i>, vol. 118, no. 8, 085302, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.118.085302\">10.1103/PhysRevLett.118.085302</a>."},"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"It is a common knowledge that an effective interaction of a quantum impurity with an electromagnetic field can be screened by surrounding charge carriers, whether mobile or static. Here we demonstrate that very strong, \"anomalous\" screening can take place in the presence of a neutral, weakly polarizable environment, due to an exchange of orbital angular momentum between the impurity and the bath. Furthermore, we show that it is possible to generalize all phenomena related to isolated impurities in an external field to the case when a many-body environment is present, by casting the problem in terms of the angulon quasiparticle. As a result, the relevant observables such as the effective Rabi frequency, geometric phase, and impurity spatial alignment are straightforward to evaluate in terms of a single parameter: the angular-momentum-dependent screening factor."}],"date_updated":"2025-06-04T08:38:44Z","type":"journal_article","volume":118,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"International IST Postdoc Fellowship Programme","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"},{"name":"Quantum rotations in the presence of a many-body environment","grant_number":"P29902","_id":"26031614-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"oa":1,"day":"22","publisher":"American Physical Society","_id":"1133","quality_controlled":"1","title":"Anomalous screening of quantum impurities by a neutral environment","scopus_import":"1","doi":"10.1103/PhysRevLett.118.085302","external_id":{"arxiv":["1612.02820"],"isi":["000394667600003"]},"oa_version":"Submitted Version","publication":"Physical Review Letters","article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1612.02820"}],"date_published":"2017-02-22T00:00:00Z","ec_funded":1,"department":[{"_id":"MiLe"}],"publication_status":"published","publication_identifier":{"issn":["0031-9007"]},"intvolume":"       118","publist_id":"6225","author":[{"orcid":"0000-0001-5973-0874","id":"38CB71F6-F248-11E8-B48F-1D18A9856A87","full_name":"Yakaboylu, Enderalp","first_name":"Enderalp","last_name":"Yakaboylu"},{"id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","full_name":"Lemeshko, Mikhail","orcid":"0000-0002-6990-7802","last_name":"Lemeshko","first_name":"Mikhail"}],"arxiv":1,"isi":1,"date_created":"2018-12-11T11:50:19Z","month":"02","status":"public","year":"2017"},{"publication":"34th International Conference on Machine Learning","acknowledgement":"We thank Tim Salimans for spotting a mistake in our preliminary arXiv manuscript. This work was funded by the European Research Council under the European Unions Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no 308036.","article_processing_charge":"No","quality_controlled":"1","title":"PixelCNN models with auxiliary variables for natural image modeling","scopus_import":"1","external_id":{"arxiv":["1612.08185"],"isi":["000683309501102"]},"oa_version":"Submitted Version","intvolume":"        70","publist_id":"6398","publication_identifier":{"isbn":["978-151085514-4"]},"author":[{"full_name":"Kolesnikov, Alexander","id":"2D157DB6-F248-11E8-B48F-1D18A9856A87","first_name":"Alexander","last_name":"Kolesnikov"},{"last_name":"Lampert","first_name":"Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","full_name":"Lampert, Christoph","orcid":"0000-0001-8622-7887"}],"arxiv":1,"date_created":"2018-12-11T11:49:37Z","isi":1,"month":"08","status":"public","year":"2017","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1612.08185"}],"date_published":"2017-08-01T00:00:00Z","ec_funded":1,"department":[{"_id":"ChLa"}],"publication_status":"published","language":[{"iso":"eng"}],"abstract":[{"text":"We study probabilistic models of natural images and extend the autoregressive family of PixelCNN models by incorporating latent variables. Subsequently, we describe two new generative image models that exploit different image transformations as latent variables: a quantized grayscale view of the image or a multi-resolution image pyramid. The proposed models tackle two known shortcomings of existing PixelCNN models: 1) their tendency to focus on low-level image details, while largely ignoring high-level image information, such as object shapes, and 2) their computationally costly procedure for image sampling. We experimentally demonstrate benefits of our LatentPixelCNN models, in particular showing that they produce much more realistically looking image samples than previous state-of-the-art probabilistic models. ","lang":"eng"}],"date_updated":"2025-04-15T07:10:22Z","type":"conference","volume":70,"project":[{"call_identifier":"FP7","grant_number":"308036","_id":"2532554C-B435-11E9-9278-68D0E5697425","name":"Lifelong Learning of Visual Scene Understanding"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"has_accepted_license":"1","conference":{"end_date":"2017-08-11","name":"ICML: International Conference on Machine Learning","location":"Sydney, Australia","start_date":"2017-08-06"},"citation":{"chicago":"Kolesnikov, Alexander, and Christoph Lampert. “PixelCNN Models with Auxiliary Variables for Natural Image Modeling.” In <i>34th International Conference on Machine Learning</i>, 70:1905–14. JMLR, 2017.","ieee":"A. Kolesnikov and C. Lampert, “PixelCNN models with auxiliary variables for natural image modeling,” in <i>34th International Conference on Machine Learning</i>, Sydney, Australia, 2017, vol. 70, pp. 1905–1914.","apa":"Kolesnikov, A., &#38; Lampert, C. (2017). PixelCNN models with auxiliary variables for natural image modeling. In <i>34th International Conference on Machine Learning</i> (Vol. 70, pp. 1905–1914). Sydney, Australia: JMLR.","ista":"Kolesnikov A, Lampert C. 2017. PixelCNN models with auxiliary variables for natural image modeling. 34th International Conference on Machine Learning. ICML: International Conference on Machine Learning vol. 70, 1905–1914.","mla":"Kolesnikov, Alexander, and Christoph Lampert. “PixelCNN Models with Auxiliary Variables for Natural Image Modeling.” <i>34th International Conference on Machine Learning</i>, vol. 70, JMLR, 2017, pp. 1905–14.","ama":"Kolesnikov A, Lampert C. PixelCNN models with auxiliary variables for natural image modeling. In: <i>34th International Conference on Machine Learning</i>. Vol 70. JMLR; 2017:1905-1914.","short":"A. Kolesnikov, C. Lampert, in:, 34th International Conference on Machine Learning, JMLR, 2017, pp. 1905–1914."},"publisher":"JMLR","day":"01","_id":"1000","page":"1905 - 1914"},{"has_accepted_license":"1","conference":{"end_date":"2017-08-25","name":"IJCAI: International Joint Conference on Artificial Intelligence ","location":"Melbourne, Australia","start_date":"2017-08-19"},"citation":{"apa":"Avni, G., Guha, S., &#38; Kupferman, O. (2017). An abstraction-refinement methodology for reasoning about network games (pp. 70–76). Presented at the IJCAI: International Joint Conference on Artificial Intelligence , Melbourne, Australia: AAAI Press. <a href=\"https://doi.org/10.24963/ijcai.2017/11\">https://doi.org/10.24963/ijcai.2017/11</a>","chicago":"Avni, Guy, Shibashis Guha, and Orna Kupferman. “An Abstraction-Refinement Methodology for Reasoning about Network Games,” 70–76. AAAI Press, 2017. <a href=\"https://doi.org/10.24963/ijcai.2017/11\">https://doi.org/10.24963/ijcai.2017/11</a>.","ieee":"G. Avni, S. Guha, and O. Kupferman, “An abstraction-refinement methodology for reasoning about network games,” presented at the IJCAI: International Joint Conference on Artificial Intelligence , Melbourne, Australia, 2017, pp. 70–76.","ista":"Avni G, Guha S, Kupferman O. 2017. An abstraction-refinement methodology for reasoning about network games. IJCAI: International Joint Conference on Artificial Intelligence , 70–76.","mla":"Avni, Guy, et al. <i>An Abstraction-Refinement Methodology for Reasoning about Network Games</i>. AAAI Press, 2017, pp. 70–76, doi:<a href=\"https://doi.org/10.24963/ijcai.2017/11\">10.24963/ijcai.2017/11</a>.","short":"G. Avni, S. Guha, O. Kupferman, in:, AAAI Press, 2017, pp. 70–76.","ama":"Avni G, Guha S, Kupferman O. An abstraction-refinement methodology for reasoning about network games. In: AAAI Press; 2017:70-76. doi:<a href=\"https://doi.org/10.24963/ijcai.2017/11\">10.24963/ijcai.2017/11</a>"},"abstract":[{"text":"Network games (NGs) are played on directed graphs and are extensively used in network design and analysis. Search problems for NGs include finding special strategy profiles such as a Nash equilibrium and a globally optimal solution. The networks modeled by NGs may be huge. In formal verification, abstraction has proven to be an extremely effective technique for reasoning about systems with big and even infinite state spaces. We describe an abstraction-refinement methodology for reasoning about NGs. Our methodology is based on an abstraction function that maps the state space of an NG to a much smaller state space. We search for a global optimum and a Nash equilibrium by reasoning on an under- and an overapproximation defined on top of this smaller state space. When the approximations are too coarse to find such profiles, we refine the abstraction function. Our experimental results demonstrate the efficiency of the methodology.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2025-07-10T11:49:38Z","type":"conference","oa":1,"project":[{"call_identifier":"FWF","_id":"25F5A88A-B435-11E9-9278-68D0E5697425","grant_number":"S11402-N23","name":"Moderne Concurrency Paradigms"},{"grant_number":"Z211","_id":"25F42A32-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Formal methods for the design and analysis of complex systems"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"70 - 76","related_material":{"record":[{"status":"public","id":"6006","relation":"later_version"}]},"day":"30","publisher":"AAAI Press","_id":"1003","title":"An abstraction-refinement methodology for reasoning about network games","quality_controlled":"1","scopus_import":"1","oa_version":"Submitted Version","doi":"10.24963/ijcai.2017/11","file_date_updated":"2018-12-12T10:16:58Z","external_id":{"isi":["000764137500011"]},"ddc":["004"],"file":[{"relation":"main_file","file_id":"5249","content_type":"application/pdf","creator":"system","file_size":365172,"file_name":"IST-2017-818-v1+1_allIJCAI_CR.pdf","access_level":"open_access","date_updated":"2018-12-12T10:16:58Z","date_created":"2018-12-12T10:16:58Z"}],"article_processing_charge":"No","date_published":"2017-05-30T00:00:00Z","pubrep_id":"818","department":[{"_id":"ToHe"}],"publication_status":"published","author":[{"last_name":"Avni","first_name":"Guy","id":"463C8BC2-F248-11E8-B48F-1D18A9856A87","full_name":"Avni, Guy","orcid":"0000-0001-5588-8287"},{"last_name":"Guha","first_name":"Shibashis","full_name":"Guha, Shibashis"},{"full_name":"Kupferman, Orna","last_name":"Kupferman","first_name":"Orna"}],"publist_id":"6395","publication_identifier":{"issn":["1045-0823"]},"date_created":"2018-12-11T11:49:38Z","isi":1,"status":"public","month":"05","year":"2017"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"type":"journal_article","volume":18,"date_updated":"2025-07-10T11:49:40Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Background: The phenomenon of immune priming, i.e. enhanced protection following a secondary exposure to a pathogen, has now been demonstrated in a wide range of invertebrate species. Despite accumulating phenotypic evidence, knowledge of its mechanistic underpinnings is currently very limited. Here we used the system of the red flour beetle, Tribolium castaneum and the insect pathogen Bacillus thuringiensis (Bt) to further our molecular understanding of the oral immune priming phenomenon. We addressed how ingestion of bacterial cues (derived from spore supernatants) of an orally pathogenic and non-pathogenic Bt strain affects gene expression upon later challenge exposure, using a whole-transcriptome sequencing approach. Results: Whereas gene expression of individuals primed with the orally non-pathogenic strain showed minor changes to controls, we found that priming with the pathogenic strain induced regulation of a large set of distinct genes, many of which are known immune candidates. Intriguingly, the immune repertoire activated upon priming and subsequent challenge qualitatively differed from the one mounted upon infection with Bt without previous priming. Moreover, a large subset of priming-specific genes showed an inverse regulation compared to their regulation upon challenge only. Conclusions: Our data demonstrate that gene expression upon infection is strongly affected by previous immune priming. We hypothesise that this shift in gene expression indicates activation of a more targeted and efficient response towards a previously encountered pathogen, in anticipation of potential secondary encounter."}],"citation":{"chicago":"Greenwood, Jenny, Barbara Milutinovic, Robert Peuß, Sarah Behrens, Daniela Essar, Philip Rosenstiel, Hinrich Schulenburg, and Joachim Kurtz. “Oral Immune Priming with Bacillus Thuringiensis Induces a Shift in the Gene Expression of Tribolium Castaneum Larvae.” <i>BMC Genomics</i>. BioMed Central, 2017. <a href=\"https://doi.org/10.1186/s12864-017-3705-7\">https://doi.org/10.1186/s12864-017-3705-7</a>.","ieee":"J. Greenwood <i>et al.</i>, “Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae,” <i>BMC Genomics</i>, vol. 18, no. 1. BioMed Central, p. 329, 2017.","apa":"Greenwood, J., Milutinovic, B., Peuß, R., Behrens, S., Essar, D., Rosenstiel, P., … Kurtz, J. (2017). Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. <i>BMC Genomics</i>. BioMed Central. <a href=\"https://doi.org/10.1186/s12864-017-3705-7\">https://doi.org/10.1186/s12864-017-3705-7</a>","ista":"Greenwood J, Milutinovic B, Peuß R, Behrens S, Essar D, Rosenstiel P, Schulenburg H, Kurtz J. 2017. Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. BMC Genomics. 18(1), 329.","mla":"Greenwood, Jenny, et al. “Oral Immune Priming with Bacillus Thuringiensis Induces a Shift in the Gene Expression of Tribolium Castaneum Larvae.” <i>BMC Genomics</i>, vol. 18, no. 1, BioMed Central, 2017, p. 329, doi:<a href=\"https://doi.org/10.1186/s12864-017-3705-7\">10.1186/s12864-017-3705-7</a>.","ama":"Greenwood J, Milutinovic B, Peuß R, et al. Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. <i>BMC Genomics</i>. 2017;18(1):329. doi:<a href=\"https://doi.org/10.1186/s12864-017-3705-7\">10.1186/s12864-017-3705-7</a>","short":"J. Greenwood, B. Milutinovic, R. Peuß, S. Behrens, D. Essar, P. Rosenstiel, H. Schulenburg, J. Kurtz, BMC Genomics 18 (2017) 329."},"issue":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","_id":"1006","day":"26","publisher":"BioMed Central","related_material":{"record":[{"id":"9859","status":"public","relation":"research_data"},{"id":"9860","status":"public","relation":"research_data"}]},"page":"329","article_processing_charge":"No","publication":"BMC Genomics","file":[{"relation":"main_file","date_created":"2018-12-12T10:16:46Z","date_updated":"2018-12-12T10:16:46Z","access_level":"open_access","file_name":"IST-2017-814-v1+1_s12864-017-3705-7.pdf","file_size":2379672,"content_type":"application/pdf","file_id":"5236","creator":"system"}],"ddc":["570"],"doi":"10.1186/s12864-017-3705-7","external_id":{"isi":["000400625200004"]},"file_date_updated":"2018-12-12T10:16:46Z","oa_version":"Published Version","scopus_import":"1","quality_controlled":"1","title":"Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae","year":"2017","month":"04","status":"public","date_created":"2018-12-11T11:49:39Z","isi":1,"intvolume":"        18","publication_identifier":{"issn":["1471-2164"]},"publist_id":"6392","author":[{"full_name":"Greenwood, Jenny","last_name":"Greenwood","first_name":"Jenny"},{"orcid":"0000-0002-8214-4758","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","full_name":"Milutinovic, Barbara","first_name":"Barbara","last_name":"Milutinovic"},{"last_name":"Peuß","first_name":"Robert","full_name":"Peuß, Robert"},{"first_name":"Sarah","last_name":"Behrens","full_name":"Behrens, Sarah"},{"full_name":"Essar, Daniela","first_name":"Daniela","last_name":"Essar"},{"full_name":"Rosenstiel, Philip","first_name":"Philip","last_name":"Rosenstiel"},{"last_name":"Schulenburg","first_name":"Hinrich","full_name":"Schulenburg, Hinrich"},{"last_name":"Kurtz","first_name":"Joachim","full_name":"Kurtz, Joachim"}],"publication_status":"published","department":[{"_id":"SyCr"}],"pubrep_id":"814","date_published":"2017-04-26T00:00:00Z"}]