[{"month":"02","publication_status":"published","date_published":"2018-02-28T00:00:00Z","article_type":"original","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","citation":{"ieee":"T. C. T. Michaels <i>et al.</i>, “Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation,” <i>Annual Review of Physical Chemistry</i>, vol. 69, no. 1. Annual Reviews, pp. 273–298, 2018.","mla":"Michaels, Thomas C. T., et al. “Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.” <i>Annual Review of Physical Chemistry</i>, vol. 69, no. 1, Annual Reviews, 2018, pp. 273–98, doi:<a href=\"https://doi.org/10.1146/annurev-physchem-050317-021322\">10.1146/annurev-physchem-050317-021322</a>.","ista":"Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ. 2018. Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation. Annual Review of Physical Chemistry. 69(1), 273–298.","apa":"Michaels, T. C. T., Šarić, A., Habchi, J., Chia, S., Meisl, G., Vendruscolo, M., … Knowles, T. P. J. (2018). Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation. <i>Annual Review of Physical Chemistry</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-physchem-050317-021322\">https://doi.org/10.1146/annurev-physchem-050317-021322</a>","short":"T.C.T. Michaels, A. Šarić, J. Habchi, S. Chia, G. Meisl, M. Vendruscolo, C.M. Dobson, T.P.J. Knowles, Annual Review of Physical Chemistry 69 (2018) 273–298.","chicago":"Michaels, Thomas C.T., Anđela Šarić, Johnny Habchi, Sean Chia, Georg Meisl, Michele Vendruscolo, Christopher M. Dobson, and Tuomas P.J. Knowles. “Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.” <i>Annual Review of Physical Chemistry</i>. Annual Reviews, 2018. <a href=\"https://doi.org/10.1146/annurev-physchem-050317-021322\">https://doi.org/10.1146/annurev-physchem-050317-021322</a>.","ama":"Michaels TCT, Šarić A, Habchi J, et al. Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation. <i>Annual Review of Physical Chemistry</i>. 2018;69(1):273-298. doi:<a href=\"https://doi.org/10.1146/annurev-physchem-050317-021322\">10.1146/annurev-physchem-050317-021322</a>"},"volume":69,"extern":"1","scopus_import":"1","publisher":"Annual Reviews","fulldoi":"https://doi.org/10.1146/annurev-physchem-050317-021322","_id":"10361","publication_identifier":{"eissn":["1545-1593"],"issn":["0066-426X"]},"pmid":1,"publication":"Annual Review of Physical Chemistry","year":"2018","external_id":{"pmid":["29490200"]},"quality_controlled":"1","page":"273-298","keyword":["physical and theoretical chemistry"],"oa_version":"None","language":[{"iso":"eng"}],"title":"Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation","date_updated":"2021-11-26T15:58:19Z","day":"28","abstract":[{"text":"Understanding how normally soluble peptides and proteins aggregate to form amyloid fibrils is central to many areas of modern biomolecular science, ranging from the development of functional biomaterials to the design of rational therapeutic strategies against increasingly prevalent medical conditions such as Alzheimer's and Parkinson's diseases. As such, there is a great need to develop models to mechanistically describe how amyloid fibrils are formed from precursor peptides and proteins. Here we review and discuss how ideas and concepts from chemical reaction kinetics can help to achieve this objective. In particular, we show how a combination of theory, experiments, and computer simulations, based on chemical kinetics, provides a general formalism for uncovering, at the molecular level, the mechanistic steps that underlie the phenomenon of amyloid fibril formation.","lang":"eng"}],"intvolume":"        69","status":"public","doi":"10.1146/annurev-physchem-050317-021322","type":"journal_article","author":[{"full_name":"Michaels, Thomas C.T.","last_name":"Michaels","first_name":"Thomas C.T."},{"full_name":"Šarić, Anđela","orcid":"0000-0002-7854-2139","last_name":"Šarić","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela"},{"first_name":"Johnny","last_name":"Habchi","full_name":"Habchi, Johnny"},{"full_name":"Chia, Sean","last_name":"Chia","first_name":"Sean"},{"full_name":"Meisl, Georg","first_name":"Georg","last_name":"Meisl"},{"first_name":"Michele","last_name":"Vendruscolo","full_name":"Vendruscolo, Michele"},{"full_name":"Dobson, Christopher M.","first_name":"Christopher M.","last_name":"Dobson"},{"first_name":"Tuomas P.J.","last_name":"Knowles","full_name":"Knowles, Tuomas P.J."}],"acknowledgement":"We acknowledge support from the Swiss National Science Foundation (T.C.T.M.); Peterhouse,\r\nCambridge (T.C.T.M.); the Royal Society (A.S.); the Academy of Medical Sciences (A.S.); the\r\nWellcome Trust (A.S., M.V., C.M.D., T.P.J.K.); the Cambridge Centre for Misfolding Diseases\r\n(M.V., C.M.D., T.P.J.K.); the Biotechnology and Biological Sciences Research Council (C.M.D.,\r\nT.P.J.K.); and the Frances and Augustus Newman Foundation (T.P.J.K.). The research leading\r\nto these results has received funding from the European Research Council (ERC) under the\r\nEuropean Union’s Seventh Framework Programme (FP7/2007-2013) through the ERC grant\r\nPhysProt (337969).","issue":"1","date_created":"2021-11-26T12:52:12Z"},{"publication":"ACS Nano","publication_identifier":{"eissn":["1936-086X"],"issn":["1936-0851"]},"_id":"10362","pmid":1,"fulldoi":"https://doi.org/10.1021/acsnano.7b08044","publisher":"American Chemical Society","scopus_import":"1","extern":"1","volume":12,"citation":{"short":"P.D.E. Fisher, Q. Shen, B. Akpinar, L.K. Davis, K.K.H. Chung, D. Baddeley, A. Šarić, T.J. Melia, B.W. Hoogenboom, C. Lin, C.P. Lusk, ACS Nano 12 (2018) 1508–1518.","apa":"Fisher, P. D. E., Shen, Q., Akpinar, B., Davis, L. K., Chung, K. K. H., Baddeley, D., … Lusk, C. P. (2018). A Programmable DNA origami platform for organizing intrinsically disordered nucleoporins within nanopore confinement. <i>ACS Nano</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsnano.7b08044\">https://doi.org/10.1021/acsnano.7b08044</a>","mla":"Fisher, Patrick D. Ellis, et al. “A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement.” <i>ACS Nano</i>, vol. 12, no. 2, American Chemical Society, 2018, pp. 1508–18, doi:<a href=\"https://doi.org/10.1021/acsnano.7b08044\">10.1021/acsnano.7b08044</a>.","ista":"Fisher PDE, Shen Q, Akpinar B, Davis LK, Chung KKH, Baddeley D, Šarić A, Melia TJ, Hoogenboom BW, Lin C, Lusk CP. 2018. A Programmable DNA origami platform for organizing intrinsically disordered nucleoporins within nanopore confinement. ACS Nano. 12(2), 1508–1518.","ieee":"P. D. E. Fisher <i>et al.</i>, “A Programmable DNA origami platform for organizing intrinsically disordered nucleoporins within nanopore confinement,” <i>ACS Nano</i>, vol. 12, no. 2. American Chemical Society, pp. 1508–1518, 2018.","chicago":"Fisher, Patrick D. Ellis, Qi Shen, Bernice Akpinar, Luke K. Davis, Kenny Kwok Hin Chung, David Baddeley, Anđela Šarić, et al. “A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement.” <i>ACS Nano</i>. American Chemical Society, 2018. <a href=\"https://doi.org/10.1021/acsnano.7b08044\">https://doi.org/10.1021/acsnano.7b08044</a>.","ama":"Fisher PDE, Shen Q, Akpinar B, et al. A Programmable DNA origami platform for organizing intrinsically disordered nucleoporins within nanopore confinement. <i>ACS Nano</i>. 2018;12(2):1508-1518. doi:<a href=\"https://doi.org/10.1021/acsnano.7b08044\">10.1021/acsnano.7b08044</a>"},"article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_type":"original","date_published":"2018-01-19T00:00:00Z","publication_status":"published","month":"01","date_created":"2021-11-26T15:15:00Z","acknowledgement":"We thank J. Edel and members of the Lusk, Lin and Hoogenboom lab for discussion and acknowledge A. Pyne and R. Thorogate for support carrying out the AFM experiments. This work was funded by the NIH (R21GM109466 to CPL, CL and TJM, DP2GM114830 to CL, RO1GM105672 to CPL, and T32GM007223 to PDEF) and the UK Engineering and Physical Sciences Research Council (EP/L015277/1, EP/L504889/1, and EP/M028100/1).","issue":"2","author":[{"full_name":"Fisher, Patrick D. Ellis","last_name":"Fisher","first_name":"Patrick D. Ellis"},{"full_name":"Shen, Qi","first_name":"Qi","last_name":"Shen"},{"first_name":"Bernice","last_name":"Akpinar","full_name":"Akpinar, Bernice"},{"full_name":"Davis, Luke K.","first_name":"Luke K.","last_name":"Davis"},{"full_name":"Chung, Kenny Kwok Hin","first_name":"Kenny Kwok Hin","last_name":"Chung"},{"full_name":"Baddeley, David","first_name":"David","last_name":"Baddeley"},{"full_name":"Šarić, Anđela","last_name":"Šarić","orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela"},{"full_name":"Melia, Thomas J.","first_name":"Thomas J.","last_name":"Melia"},{"full_name":"Hoogenboom, Bart W.","first_name":"Bart W.","last_name":"Hoogenboom"},{"full_name":"Lin, Chenxiang","last_name":"Lin","first_name":"Chenxiang"},{"full_name":"Lusk, C. Patrick","first_name":"C. Patrick","last_name":"Lusk"}],"type":"journal_article","status":"public","doi":"10.1021/acsnano.7b08044","intvolume":"        12","abstract":[{"lang":"eng","text":"Nuclear pore complexes (NPCs) form gateways that control molecular exchange between the nucleus and the cytoplasm. They impose a diffusion barrier to macromolecules and enable the selective transport of nuclear transport receptors with bound cargo. The underlying mechanisms that establish these permeability properties remain to be fully elucidated but require unstructured nuclear pore proteins rich in Phe-Gly (FG)-repeat domains of different types, such as FxFG and GLFG. While physical modeling and in vitro approaches have provided a framework for explaining how the FG network contributes to the barrier and transport properties of the NPC, it remains unknown whether the number and/or the spatial positioning of different FG-domains along a cylindrical, ∼40 nm diameter transport channel contributes to their collective properties and function. To begin to answer these questions, we have used DNA origami to build a cylinder that mimics the dimensions of the central transport channel and can house a specified number of FG-domains at specific positions with easily tunable design parameters, such as grafting density and topology. We find the overall morphology of the FG-domain assemblies to be dependent on their chemical composition, determined by the type and density of FG-repeat, and on their architectural confinement provided by the DNA cylinder, largely consistent with here presented molecular dynamics simulations based on a coarse-grained polymer model. In addition, high-speed atomic force microscopy reveals local and reversible FG-domain condensation that transiently occludes the lumen of the DNA central channel mimics, suggestive of how the NPC might establish its permeability properties."}],"title":"A Programmable DNA origami platform for organizing intrinsically disordered nucleoporins within nanopore confinement","date_updated":"2021-11-26T15:57:02Z","day":"19","oa_version":"None","language":[{"iso":"eng"}],"page":"1508-1518","keyword":["general physics and astronomy"],"quality_controlled":"1","external_id":{"pmid":["29350911"]},"year":"2018"},{"month":"10","publication_status":"published","date_published":"2018-10-01T00:00:00Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","department":[{"_id":"GradSch"}],"article_processing_charge":"No","citation":{"ieee":"D. Seitner, S. Uhse, M. C. Gallei, and A. Djamei, “The core effector Cce1 is required for early infection of maize by Ustilago maydis,” <i>Molecular Plant Pathology</i>, vol. 19, no. 10. Wiley, pp. 2277–2287, 2018.","short":"D. Seitner, S. Uhse, M.C. Gallei, A. Djamei, Molecular Plant Pathology 19 (2018) 2277–2287.","ista":"Seitner D, Uhse S, Gallei MC, Djamei A. 2018. The core effector Cce1 is required for early infection of maize by Ustilago maydis. Molecular Plant Pathology. 19(10), 2277–2287.","mla":"Seitner, Denise, et al. “The Core Effector Cce1 Is Required for Early Infection of Maize by Ustilago Maydis.” <i>Molecular Plant Pathology</i>, vol. 19, no. 10, Wiley, 2018, pp. 2277–87, doi:<a href=\"https://doi.org/10.1111/mpp.12698\">10.1111/mpp.12698</a>.","apa":"Seitner, D., Uhse, S., Gallei, M. C., &#38; Djamei, A. (2018). The core effector Cce1 is required for early infection of maize by Ustilago maydis. <i>Molecular Plant Pathology</i>. Wiley. <a href=\"https://doi.org/10.1111/mpp.12698\">https://doi.org/10.1111/mpp.12698</a>","ama":"Seitner D, Uhse S, Gallei MC, Djamei A. The core effector Cce1 is required for early infection of maize by Ustilago maydis. <i>Molecular Plant Pathology</i>. 2018;19(10):2277-2287. doi:<a href=\"https://doi.org/10.1111/mpp.12698\">10.1111/mpp.12698</a>","chicago":"Seitner, Denise, Simon Uhse, Michelle C Gallei, and Armin Djamei. “The Core Effector Cce1 Is Required for Early Infection of Maize by Ustilago Maydis.” <i>Molecular Plant Pathology</i>. Wiley, 2018. <a href=\"https://doi.org/10.1111/mpp.12698\">https://doi.org/10.1111/mpp.12698</a>."},"volume":19,"has_accepted_license":"1","oa":1,"scopus_import":"1","publisher":"Wiley","fulldoi":"https://doi.org/10.1111/mpp.12698","_id":"104","publication":"Molecular Plant Pathology","year":"2018","external_id":{"isi":["000445624100006"]},"license":"https://creativecommons.org/licenses/by/4.0/","quality_controlled":"1","isi":1,"page":"2277 - 2287","oa_version":"Published Version","language":[{"iso":"eng"}],"day":"01","title":"The core effector Cce1 is required for early infection of maize by Ustilago maydis","publist_id":"7950","date_updated":"2023-09-19T10:06:42Z","abstract":[{"text":"The biotrophic pathogen Ustilago maydis, the causative agent of corn smut disease, infects one of the most important crops worldwide – Zea mays. To successfully colonize its host, U. maydis secretes proteins, known as effectors, that suppress plant defense responses and facilitate the establishment of biotrophy. In this work, we describe the U. maydis effector protein Cce1. Cce1 is essential for virulence and is upregulated during infection. Through microscopic analysis and in vitro assays, we show that Cce1 is secreted from hyphae during filamentous growth of the fungus. Strikingly, Δcce1 mutants are blocked at early stages of infection and induce callose deposition as a plant defense response. Cce1 is highly conserved among smut fungi and the Ustilago bromivora ortholog complemented the virulence defect of the SG200Δcce1 deletion strain. These data indicate that Cce1 is a core effector with apoplastic localization that is essential for U. maydis to infect its host.","lang":"eng"}],"file":[{"file_size":682335,"relation":"main_file","access_level":"open_access","date_updated":"2018-12-18T09:46:00Z","file_name":"2018_MolecPlantPath_Seitner.pdf","success":1,"content_type":"application/pdf","creator":"dernst","file_id":"5740","date_created":"2018-12-18T09:46:00Z"}],"intvolume":"        19","doi":"10.1111/mpp.12698","file_date_updated":"2018-12-18T09:46:00Z","status":"public","type":"journal_article","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"author":[{"first_name":"Denise","last_name":"Seitner","full_name":"Seitner, Denise"},{"full_name":"Uhse, Simon","last_name":"Uhse","first_name":"Simon"},{"last_name":"Gallei","orcid":"0000-0003-1286-7368","id":"35A03822-F248-11E8-B48F-1D18A9856A87","first_name":"Michelle C","full_name":"Gallei, Michelle C"},{"last_name":"Djamei","first_name":"Armin","full_name":"Djamei, Armin"}],"ddc":["580"],"issue":"10","acknowledgement":"the Austrian Science Fund (FWF): [P27429‐B22, P27818‐B22, I 3033‐B22], and the Austrian Academy of Science (OEAW).","date_created":"2018-12-11T11:44:39Z"},{"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"author":[{"full_name":"Chalupa, Marek","first_name":"Marek","last_name":"Chalupa"},{"last_name":"Chatterjee","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu"},{"orcid":"0000-0002-8943-0722","last_name":"Pavlogiannis","first_name":"Andreas","id":"49704004-F248-11E8-B48F-1D18A9856A87","full_name":"Pavlogiannis, Andreas"},{"full_name":"Sinha, Nishant","last_name":"Sinha","first_name":"Nishant"},{"first_name":"Kapil","last_name":"Vaidya","full_name":"Vaidya, Kapil"}],"ddc":["000"],"acknowledgement":"The research was partly supported by Austrian Science Fund (FWF) Grant No P23499- N23, FWF\r\nNFN Grant No S11407-N23 (RiSE/SHiNE), ERC Start grant (279307: Graph Games), and Czech\r\nScience Foundation grant GBP202/12/G061.","issue":"POPL","date_created":"2021-12-05T23:01:49Z","OA_type":"hybrid","file_date_updated":"2025-05-20T09:44:47Z","status":"public","doi":"10.1145/3158119","type":"journal_article","conference":{"location":"Los Angeles, CA, United States","name":"POPL: Programming Languages","start_date":"2018-01-07","end_date":"2018-01-13"},"language":[{"iso":"eng"}],"oa_version":"Published Version","day":"01","date_updated":"2025-05-20T09:45:10Z","title":"Data-centric dynamic partial order reduction","abstract":[{"lang":"eng","text":"We present a new dynamic partial-order reduction method for stateless model checking of concurrent programs. A common approach for exploring program behaviors relies on enumerating the traces of the program, without storing the visited states (aka stateless exploration). As the number of distinct traces grows exponentially, dynamic partial-order reduction (DPOR) techniques have been successfully used to partition the space of traces into equivalence classes (Mazurkiewicz partitioning), with the goal of exploring only few representative traces from each class.\r\n\r\nWe introduce a new equivalence on traces under sequential consistency semantics, which we call the observation equivalence. Two traces are observationally equivalent if every read event observes the same write event in both traces. While the traditional Mazurkiewicz equivalence is control-centric, our new definition is data-centric. We show that our observation equivalence is coarser than the Mazurkiewicz equivalence, and in many cases even exponentially coarser. We devise a DPOR exploration of the trace space, called data-centric DPOR, based on the observation equivalence."}],"article_number":"31","file":[{"date_created":"2025-05-20T09:44:47Z","file_id":"19716","success":1,"creator":"dernst","content_type":"application/pdf","checksum":"b27ab1745f6dba2387deb785798a657c","date_updated":"2025-05-20T09:44:47Z","file_name":"2018_ACM_Chalupa.pdf","access_level":"open_access","relation":"main_file","file_size":388891}],"intvolume":"         2","year":"2018","external_id":{"arxiv":["1610.01188"]},"quality_controlled":"1","scopus_import":"1","publisher":"Association for Computing Machinery","fulldoi":"https://doi.org/10.1145/3158119","_id":"10417","publication_identifier":{"eissn":["2475-1421"]},"publication":"Proceedings of the ACM on Programming Languages","arxiv":1,"OA_place":"publisher","project":[{"name":"Modern Graph Algorithmic Techniques in Formal Verification","grant_number":"P 23499-N23","call_identifier":"FWF","_id":"2584A770-B435-11E9-9278-68D0E5697425"},{"name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425"},{"_id":"2581B60A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"279307","name":"Quantitative Graph Games: Theory and Applications"}],"has_accepted_license":"1","oa":1,"department":[{"_id":"KrCh"}],"article_processing_charge":"No","ec_funded":1,"citation":{"chicago":"Chalupa, Marek, Krishnendu Chatterjee, Andreas Pavlogiannis, Nishant Sinha, and Kapil Vaidya. “Data-Centric Dynamic Partial Order Reduction.” <i>Proceedings of the ACM on Programming Languages</i>. Association for Computing Machinery, 2018. <a href=\"https://doi.org/10.1145/3158119\">https://doi.org/10.1145/3158119</a>.","ama":"Chalupa M, Chatterjee K, Pavlogiannis A, Sinha N, Vaidya K. Data-centric dynamic partial order reduction. <i>Proceedings of the ACM on Programming Languages</i>. 2018;2(POPL). doi:<a href=\"https://doi.org/10.1145/3158119\">10.1145/3158119</a>","ieee":"M. Chalupa, K. Chatterjee, A. Pavlogiannis, N. Sinha, and K. Vaidya, “Data-centric dynamic partial order reduction,” <i>Proceedings of the ACM on Programming Languages</i>, vol. 2, no. POPL. Association for Computing Machinery, 2018.","short":"M. Chalupa, K. Chatterjee, A. Pavlogiannis, N. Sinha, K. Vaidya, Proceedings of the ACM on Programming Languages 2 (2018).","apa":"Chalupa, M., Chatterjee, K., Pavlogiannis, A., Sinha, N., &#38; Vaidya, K. (2018). Data-centric dynamic partial order reduction. <i>Proceedings of the ACM on Programming Languages</i>. Los Angeles, CA, United States: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3158119\">https://doi.org/10.1145/3158119</a>","mla":"Chalupa, Marek, et al. “Data-Centric Dynamic Partial Order Reduction.” <i>Proceedings of the ACM on Programming Languages</i>, vol. 2, no. POPL, 31, Association for Computing Machinery, 2018, doi:<a href=\"https://doi.org/10.1145/3158119\">10.1145/3158119</a>.","ista":"Chalupa M, Chatterjee K, Pavlogiannis A, Sinha N, Vaidya K. 2018. Data-centric dynamic partial order reduction. Proceedings of the ACM on Programming Languages. 2(POPL), 31."},"volume":2,"month":"01","date_published":"2018-01-01T00:00:00Z","publication_status":"published","article_type":"original","related_material":{"record":[{"id":"5448","status":"public","relation":"earlier_version"},{"relation":"earlier_version","id":"5456","status":"public"}]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"type":"journal_article","doi":"10.1007/s00283-018-9795-5","status":"public","author":[{"full_name":"Akopyan, Arseniy","last_name":"Akopyan","orcid":"0000-0002-2548-617X","id":"430D2C90-F248-11E8-B48F-1D18A9856A87","first_name":"Arseniy"},{"last_name":"Petrunin","first_name":"Anton","full_name":"Petrunin, Anton"}],"date_created":"2018-12-11T11:44:40Z","main_file_link":[{"url":"https://arxiv.org/abs/1702.05172","open_access":"1"}],"issue":"3","external_id":{"arxiv":["1702.05172"],"isi":["000444141200005"]},"year":"2018","isi":1,"page":"26 - 31","quality_controlled":"1","day":"01","publist_id":"7948","date_updated":"2023-09-13T08:49:16Z","title":"Long geodesics on convex surfaces","oa_version":"Preprint","language":[{"iso":"eng"}],"intvolume":"        40","abstract":[{"text":"The goal of this article is to introduce the reader to the theory of intrinsic geometry of convex surfaces. We illustrate the power of the tools by proving a theorem on convex surfaces containing an arbitrarily long closed simple geodesic. Let us remind ourselves that a curve in a surface is called geodesic if every sufficiently short arc of the curve is length minimizing; if, in addition, it has no self-intersections, we call it simple geodesic. A tetrahedron with equal opposite edges is called isosceles. The axiomatic method of Alexandrov geometry allows us to work with the metrics of convex surfaces directly, without approximating it first by a smooth or polyhedral metric. Such approximations destroy the closed geodesics on the surface; therefore it is difficult (if at all possible) to apply approximations in the proof of our theorem. On the other hand, a proof in the smooth or polyhedral case usually admits a translation into Alexandrov’s language; such translation makes the result more general. In fact, our proof resembles a translation of the proof given by Protasov. Note that the main theorem implies in particular that a smooth convex surface does not have arbitrarily long simple closed geodesics. However we do not know a proof of this corollary that is essentially simpler than the one presented below.","lang":"eng"}],"arxiv":1,"oa":1,"fulldoi":"https://doi.org/10.1007/s00283-018-9795-5","publisher":"Springer","scopus_import":"1","publication":"Mathematical Intelligencer","_id":"106","publication_status":"published","date_published":"2018-09-01T00:00:00Z","month":"09","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","article_processing_charge":"No","department":[{"_id":"HeEd"}],"volume":40,"citation":{"apa":"Akopyan, A., &#38; Petrunin, A. (2018). Long geodesics on convex surfaces. <i>Mathematical Intelligencer</i>. Springer. <a href=\"https://doi.org/10.1007/s00283-018-9795-5\">https://doi.org/10.1007/s00283-018-9795-5</a>","mla":"Akopyan, Arseniy, and Anton Petrunin. “Long Geodesics on Convex Surfaces.” <i>Mathematical Intelligencer</i>, vol. 40, no. 3, Springer, 2018, pp. 26–31, doi:<a href=\"https://doi.org/10.1007/s00283-018-9795-5\">10.1007/s00283-018-9795-5</a>.","ista":"Akopyan A, Petrunin A. 2018. Long geodesics on convex surfaces. Mathematical Intelligencer. 40(3), 26–31.","short":"A. Akopyan, A. Petrunin, Mathematical Intelligencer 40 (2018) 26–31.","ieee":"A. Akopyan and A. Petrunin, “Long geodesics on convex surfaces,” <i>Mathematical Intelligencer</i>, vol. 40, no. 3. Springer, pp. 26–31, 2018.","chicago":"Akopyan, Arseniy, and Anton Petrunin. “Long Geodesics on Convex Surfaces.” <i>Mathematical Intelligencer</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s00283-018-9795-5\">https://doi.org/10.1007/s00283-018-9795-5</a>.","ama":"Akopyan A, Petrunin A. Long geodesics on convex surfaces. <i>Mathematical Intelligencer</i>. 2018;40(3):26-31. doi:<a href=\"https://doi.org/10.1007/s00283-018-9795-5\">10.1007/s00283-018-9795-5</a>"}},{"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1805.04199"}],"acknowledgement":"We thank Cory Dean, S. Chen, Y. Zeng, M. Yankowitz, and J. Li for discussing their unpublished data and for sharing the stack inversion technique. The authors acknowledge further discussions of the results with I. Sodemann, M. Zaletel, C. Nayak, and J. Jain. A. F. Y., H. P., H. Z., and E. M. S. were supported by the ARO under awards 69188PHH and MURI W911NF-17-1-0323. A portion of this work was performed at the National High Magnetic Field Laboratory, which is supported by National Science Foundation Cooperative Agreement No. DMR-1644779 and the State of Florida. K. W. and T. T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan, and JSPS KAKENHI Grant No. JP15K21722. E. M. S. acknowledges the support of the Elings Prize Fellowship in Science of the California Nanosystems Institute at the University of California, Santa Barbara. A. F. Y. acknowledges the support of the David and Lucile Packard Foundation.","issue":"22","date_created":"2022-01-14T12:15:47Z","author":[{"full_name":"Polshyn, Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy","last_name":"Polshyn","orcid":"0000-0001-8223-8896"},{"full_name":"Zhou, H.","last_name":"Zhou","first_name":"H."},{"last_name":"Spanton","first_name":"E. M.","full_name":"Spanton, E. M."},{"first_name":"T.","last_name":"Taniguchi","full_name":"Taniguchi, T."},{"full_name":"Watanabe, K.","last_name":"Watanabe","first_name":"K."},{"first_name":"A. F.","last_name":"Young","full_name":"Young, A. F."}],"doi":"10.1103/physrevlett.121.226801","status":"public","type":"journal_article","article_number":"226801","abstract":[{"lang":"eng","text":"Owing to their wide tunability, multiple internal degrees of freedom, and low disorder, graphene heterostructures are emerging as a promising experimental platform for fractional quantum Hall (FQH) studies. Here, we report FQH thermal activation gap measurements in dual graphite-gated monolayer graphene devices fabricated in an edgeless Corbino geometry. In devices with substrate-induced sublattice splitting, we find a tunable crossover between single- and multicomponent FQH states in the zero energy Landau level. Activation gaps in the single-component regime show excellent agreement with numerical calculations using a single broadening parameter \r\nΓ≈7.2K. In the first excited Landau level, in contrast, FQH gaps are strongly influenced by Landau level mixing, and we observe an unexpected valley-ordered state at integer filling ν=−4."}],"intvolume":"       121","language":[{"iso":"eng"}],"oa_version":"Preprint","day":"28","date_updated":"2022-01-14T13:48:35Z","title":"Quantitative transport measurements of fractional quantum Hall energy gaps in edgeless graphene devices","quality_controlled":"1","keyword":["general physics and astronomy"],"year":"2018","external_id":{"arxiv":["1805.04199"]},"_id":"10626","publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"publication":"Physical Review Letters","publisher":"American Physical Society","scopus_import":"1","fulldoi":"https://doi.org/10.1103/physrevlett.121.226801","extern":"1","oa":1,"arxiv":1,"citation":{"chicago":"Polshyn, Hryhoriy, H. Zhou, E. M. Spanton, T. Taniguchi, K. Watanabe, and A. F. Young. “Quantitative Transport Measurements of Fractional Quantum Hall Energy Gaps in Edgeless Graphene Devices.” <i>Physical Review Letters</i>. American Physical Society, 2018. <a href=\"https://doi.org/10.1103/physrevlett.121.226801\">https://doi.org/10.1103/physrevlett.121.226801</a>.","ama":"Polshyn H, Zhou H, Spanton EM, Taniguchi T, Watanabe K, Young AF. Quantitative transport measurements of fractional quantum Hall energy gaps in edgeless graphene devices. <i>Physical Review Letters</i>. 2018;121(22). doi:<a href=\"https://doi.org/10.1103/physrevlett.121.226801\">10.1103/physrevlett.121.226801</a>","ieee":"H. Polshyn, H. Zhou, E. M. Spanton, T. Taniguchi, K. Watanabe, and A. F. Young, “Quantitative transport measurements of fractional quantum Hall energy gaps in edgeless graphene devices,” <i>Physical Review Letters</i>, vol. 121, no. 22. American Physical Society, 2018.","mla":"Polshyn, Hryhoriy, et al. “Quantitative Transport Measurements of Fractional Quantum Hall Energy Gaps in Edgeless Graphene Devices.” <i>Physical Review Letters</i>, vol. 121, no. 22, 226801, American Physical Society, 2018, doi:<a href=\"https://doi.org/10.1103/physrevlett.121.226801\">10.1103/physrevlett.121.226801</a>.","apa":"Polshyn, H., Zhou, H., Spanton, E. M., Taniguchi, T., Watanabe, K., &#38; Young, A. F. (2018). Quantitative transport measurements of fractional quantum Hall energy gaps in edgeless graphene devices. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.121.226801\">https://doi.org/10.1103/physrevlett.121.226801</a>","ista":"Polshyn H, Zhou H, Spanton EM, Taniguchi T, Watanabe K, Young AF. 2018. Quantitative transport measurements of fractional quantum Hall energy gaps in edgeless graphene devices. Physical Review Letters. 121(22), 226801.","short":"H. Polshyn, H. Zhou, E.M. Spanton, T. Taniguchi, K. Watanabe, A.F. Young, Physical Review Letters 121 (2018)."},"volume":121,"article_processing_charge":"No","article_type":"original","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","month":"11","publication_status":"published","date_published":"2018-11-28T00:00:00Z"},{"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1703.08184"}],"issue":"18","acknowledgement":"We are grateful to Nadya Mason for useful discussions. This work was supported by the DOE Basic Energy Sciences under Contract No. DE-SC0012649, the Department of Physics and the Frederick Seitz Materials Research Laboratory Central Facilities at the University of Illinois.\r\n","date_created":"2022-01-14T13:48:47Z","author":[{"full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896","last_name":"Polshyn","first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48"},{"full_name":"Naibert, Tyler R.","first_name":"Tyler R.","last_name":"Naibert"},{"full_name":"Budakian, Raffi","first_name":"Raffi","last_name":"Budakian"}],"status":"public","doi":"10.1103/physrevb.97.184501","type":"journal_article","abstract":[{"text":"We present a scanning probe technique for measuring the dynamics of individual fluxoid transitions in multiply connected superconducting structures. In these measurements, a small magnetic particle attached to the tip of a silicon cantilever is scanned over a micron-size superconducting ring fabricated from a thin aluminum film. We find that near the superconducting transition temperature of the aluminum, the dissipation and frequency of the cantilever changes significantly at particular locations where the tip-induced magnetic flux penetrating the ring causes the two lowest-energy fluxoid states to become nearly degenerate. In this regime, we show that changes in the cantilever frequency and dissipation are well-described by a stochastic resonance (SR) process, wherein small oscillations of the cantilever in the presence of thermally activated phase slips (TAPS) in the ring give rise to a dynamical force that modifies the mechanical properties of the cantilever. Using the SR model, we calculate the average fluctuation rate of the TAPS as a function of temperature over a 32-dB range in frequency, and we compare it to the Langer-Ambegaokar-McCumber-Halperin theory for TAPS in one-dimensional superconducting structures.","lang":"eng"}],"article_number":"184501","intvolume":"        97","oa_version":"Preprint","language":[{"iso":"eng"}],"day":"08","title":"Imaging phase slip dynamics in micron-size superconducting rings","date_updated":"2022-01-14T13:58:24Z","quality_controlled":"1","year":"2018","external_id":{"arxiv":["1703.08184"]},"_id":"10627","publication_identifier":{"issn":["2469-9950"],"eissn":["2469-9969"]},"publication":"Physical Review B","scopus_import":"1","publisher":"American Physical Society","fulldoi":"https://doi.org/10.1103/physrevb.97.184501","extern":"1","oa":1,"arxiv":1,"citation":{"ama":"Polshyn H, Naibert TR, Budakian R. Imaging phase slip dynamics in micron-size superconducting rings. <i>Physical Review B</i>. 2018;97(18). doi:<a href=\"https://doi.org/10.1103/physrevb.97.184501\">10.1103/physrevb.97.184501</a>","chicago":"Polshyn, Hryhoriy, Tyler R. Naibert, and Raffi Budakian. “Imaging Phase Slip Dynamics in Micron-Size Superconducting Rings.” <i>Physical Review B</i>. American Physical Society, 2018. <a href=\"https://doi.org/10.1103/physrevb.97.184501\">https://doi.org/10.1103/physrevb.97.184501</a>.","short":"H. Polshyn, T.R. Naibert, R. Budakian, Physical Review B 97 (2018).","mla":"Polshyn, Hryhoriy, et al. “Imaging Phase Slip Dynamics in Micron-Size Superconducting Rings.” <i>Physical Review B</i>, vol. 97, no. 18, 184501, American Physical Society, 2018, doi:<a href=\"https://doi.org/10.1103/physrevb.97.184501\">10.1103/physrevb.97.184501</a>.","apa":"Polshyn, H., Naibert, T. R., &#38; Budakian, R. (2018). Imaging phase slip dynamics in micron-size superconducting rings. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevb.97.184501\">https://doi.org/10.1103/physrevb.97.184501</a>","ista":"Polshyn H, Naibert TR, Budakian R. 2018. Imaging phase slip dynamics in micron-size superconducting rings. Physical Review B. 97(18), 184501.","ieee":"H. Polshyn, T. R. Naibert, and R. Budakian, “Imaging phase slip dynamics in micron-size superconducting rings,” <i>Physical Review B</i>, vol. 97, no. 18. American Physical Society, 2018."},"volume":97,"article_processing_charge":"No","article_type":"original","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","month":"05","date_published":"2018-05-08T00:00:00Z","publication_status":"published"},{"date_published":"2018-06-01T00:00:00Z","publication_status":"published","month":"06","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"HeEd"}],"volume":59,"citation":{"ieee":"A. Akopyan, A. Balitskiy, and M. Grigorev, “On the circle covering theorem by A.W. Goodman and R.E. Goodman,” <i>Discrete &#38; Computational Geometry</i>, vol. 59, no. 4. Springer, pp. 1001–1009, 2018.","short":"A. Akopyan, A. Balitskiy, M. Grigorev, Discrete &#38; Computational Geometry 59 (2018) 1001–1009.","mla":"Akopyan, Arseniy, et al. “On the Circle Covering Theorem by A.W. Goodman and R.E. Goodman.” <i>Discrete &#38; Computational Geometry</i>, vol. 59, no. 4, Springer, 2018, pp. 1001–09, doi:<a href=\"https://doi.org/10.1007/s00454-017-9883-x\">10.1007/s00454-017-9883-x</a>.","ista":"Akopyan A, Balitskiy A, Grigorev M. 2018. On the circle covering theorem by A.W. Goodman and R.E. Goodman. Discrete &#38; Computational Geometry. 59(4), 1001–1009.","apa":"Akopyan, A., Balitskiy, A., &#38; Grigorev, M. (2018). On the circle covering theorem by A.W. Goodman and R.E. Goodman. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-017-9883-x\">https://doi.org/10.1007/s00454-017-9883-x</a>","chicago":"Akopyan, Arseniy, Alexey Balitskiy, and Mikhail Grigorev. “On the Circle Covering Theorem by A.W. Goodman and R.E. Goodman.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s00454-017-9883-x\">https://doi.org/10.1007/s00454-017-9883-x</a>.","ama":"Akopyan A, Balitskiy A, Grigorev M. On the circle covering theorem by A.W. Goodman and R.E. Goodman. <i>Discrete &#38; Computational Geometry</i>. 2018;59(4):1001-1009. doi:<a href=\"https://doi.org/10.1007/s00454-017-9883-x\">10.1007/s00454-017-9883-x</a>"},"ec_funded":1,"project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"}],"oa":1,"has_accepted_license":"1","fulldoi":"https://doi.org/10.1007/s00454-017-9883-x","scopus_import":"1","publisher":"Springer","publication":"Discrete & Computational Geometry","publication_identifier":{"eissn":["1432-0444"],"issn":["0179-5376"]},"_id":"1064","external_id":{"isi":["000432205500011"]},"year":"2018","page":"1001-1009","isi":1,"quality_controlled":"1","title":"On the circle covering theorem by A.W. Goodman and R.E. Goodman","date_updated":"2026-05-20T10:19:33Z","publist_id":"6324","day":"01","oa_version":"Published Version","language":[{"iso":"eng"}],"intvolume":"        59","file":[{"file_size":482518,"relation":"main_file","access_level":"open_access","file_name":"2018_DiscreteComp_Akopyan.pdf","date_updated":"2019-01-18T09:27:36Z","success":1,"content_type":"application/pdf","creator":"dernst","file_id":"5844","date_created":"2019-01-18T09:27:36Z"}],"abstract":[{"lang":"eng","text":"In 1945, A.W. Goodman and R.E. Goodman proved the following conjecture by P. Erdős: Given a family of (round) disks of radii r1, … , rn in the plane, it is always possible to cover them by a disk of radius R= ∑ ri, provided they cannot be separated into two subfamilies by a straight line disjoint from the disks. In this note we show that essentially the same idea may work for different analogues and generalizations of their result. In particular, we prove the following: Given a family of positive homothetic copies of a fixed convex body K⊂ Rd with homothety coefficients τ1, … , τn> 0 , it is always possible to cover them by a translate of d+12(∑τi)K, provided they cannot be separated into two subfamilies by a hyperplane disjoint from the homothets."}],"type":"journal_article","doi":"10.1007/s00454-017-9883-x","file_date_updated":"2019-01-18T09:27:36Z","status":"public","ddc":["516","000"],"author":[{"full_name":"Akopyan, Arseniy","last_name":"Akopyan","orcid":"0000-0002-2548-617X","first_name":"Arseniy","id":"430D2C90-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Balitskiy, Alexey","first_name":"Alexey","last_name":"Balitskiy"},{"full_name":"Grigorev, Mikhail","first_name":"Mikhail","last_name":"Grigorev"}],"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"corr_author":"1","date_created":"2018-12-11T11:49:57Z","issue":"4"},{"doi":"10.1145/3178432","status":"public","type":"journal_article","main_file_link":[{"url":"https://eprint.iacr.org/2009/608","open_access":"1"}],"issue":"4","date_created":"2018-12-11T11:44:40Z","author":[{"full_name":"Dziembowski, Stefan","last_name":"Dziembowski","first_name":"Stefan"},{"orcid":"0000-0002-9139-1654","last_name":"Pietrzak","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","first_name":"Krzysztof Z","full_name":"Pietrzak, Krzysztof Z"},{"full_name":"Wichs, Daniel","last_name":"Wichs","first_name":"Daniel"}],"quality_controlled":"1","isi":1,"year":"2018","external_id":{"isi":["000442938200004"]},"article_number":"20","abstract":[{"lang":"eng","text":"We introduce the notion of “non-malleable codes” which relaxes the notion of error correction and error detection. Informally, a code is non-malleable if the message contained in a modified codeword is either the original message, or a completely unrelated value. In contrast to error correction and error detection, non-malleability can be achieved for very rich classes of modifications. We construct an efficient code that is non-malleable with respect to modifications that affect each bit of the codeword arbitrarily (i.e., leave it untouched, flip it, or set it to either 0 or 1), but independently of the value of the other bits of the codeword. Using the probabilistic method, we also show a very strong and general statement: there exists a non-malleable code for every “small enough” family F of functions via which codewords can be modified. Although this probabilistic method argument does not directly yield efficient constructions, it gives us efficient non-malleable codes in the random-oracle model for very general classes of tampering functions—e.g., functions where every bit in the tampered codeword can depend arbitrarily on any 99% of the bits in the original codeword. As an application of non-malleable codes, we show that they provide an elegant algorithmic solution to the task of protecting functionalities implemented in hardware (e.g., signature cards) against “tampering attacks.” In such attacks, the secret state of a physical system is tampered, in the hopes that future interaction with the modified system will reveal some secret information. This problem was previously studied in the work of Gennaro et al. in 2004 under the name “algorithmic tamper proof security” (ATP). We show that non-malleable codes can be used to achieve important improvements over the prior work. In particular, we show that any functionality can be made secure against a large class of tampering attacks, simply by encoding the secret state with a non-malleable code while it is stored in memory."}],"intvolume":"        65","language":[{"iso":"eng"}],"oa_version":"Preprint","day":"01","publist_id":"7947","title":"Non-malleable codes","date_updated":"2025-04-14T07:22:06Z","oa":1,"project":[{"_id":"258AA5B2-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"682815","name":"Teaching Old Crypto New Tricks"},{"_id":"258C570E-B435-11E9-9278-68D0E5697425","name":"Provable Security for Physical Cryptography","grant_number":"259668","call_identifier":"FP7"}],"_id":"107","publication":"Journal of the ACM","scopus_import":"1","publisher":"ACM","fulldoi":"https://doi.org/10.1145/3178432","article_type":"original","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","month":"08","date_published":"2018-08-01T00:00:00Z","publication_status":"published","ec_funded":1,"citation":{"ieee":"S. Dziembowski, K. Z. Pietrzak, and D. Wichs, “Non-malleable codes,” <i>Journal of the ACM</i>, vol. 65, no. 4. ACM, 2018.","short":"S. Dziembowski, K.Z. Pietrzak, D. Wichs, Journal of the ACM 65 (2018).","apa":"Dziembowski, S., Pietrzak, K. Z., &#38; Wichs, D. (2018). Non-malleable codes. <i>Journal of the ACM</i>. ACM. <a href=\"https://doi.org/10.1145/3178432\">https://doi.org/10.1145/3178432</a>","mla":"Dziembowski, Stefan, et al. “Non-Malleable Codes.” <i>Journal of the ACM</i>, vol. 65, no. 4, 20, ACM, 2018, doi:<a href=\"https://doi.org/10.1145/3178432\">10.1145/3178432</a>.","ista":"Dziembowski S, Pietrzak KZ, Wichs D. 2018. Non-malleable codes. Journal of the ACM. 65(4), 20.","chicago":"Dziembowski, Stefan, Krzysztof Z Pietrzak, and Daniel Wichs. “Non-Malleable Codes.” <i>Journal of the ACM</i>. ACM, 2018. <a href=\"https://doi.org/10.1145/3178432\">https://doi.org/10.1145/3178432</a>.","ama":"Dziembowski S, Pietrzak KZ, Wichs D. Non-malleable codes. <i>Journal of the ACM</i>. 2018;65(4). doi:<a href=\"https://doi.org/10.1145/3178432\">10.1145/3178432</a>"},"volume":65,"department":[{"_id":"KrPi"}],"article_processing_charge":"No"},{"alternative_title":["ISIT Proceedings"],"author":[{"last_name":"Obremski","first_name":"Marciej","full_name":"Obremski, Marciej"},{"last_name":"Skorski","id":"EC09FA6A-02D0-11E9-8223-86B7C91467DD","first_name":"Maciej","full_name":"Skorski, Maciej"}],"main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2017/507"}],"date_created":"2018-12-11T11:44:40Z","status":"public","doi":"10.1109/ISIT.2018.8437654","type":"conference","conference":{"end_date":"2018-06-22","location":"Vail, CO, USA","name":"ISIT: International Symposium on Information Theory","start_date":"2018-06-17 "},"oa_version":"Submitted Version","language":[{"iso":"eng"}],"day":"16","date_updated":"2023-09-13T08:23:18Z","publist_id":"7946","title":"Inverted leftover hash lemma","abstract":[{"lang":"eng","text":"Universal hashing found a lot of applications in computer science. In cryptography the most important fact about universal families is the so called Leftover Hash Lemma, proved by Impagliazzo, Levin and Luby. In the language of modern cryptography it states that almost universal families are good extractors. In this work we provide a somewhat surprising characterization in the opposite direction. Namely, every extractor with sufficiently good parameters yields a universal family on a noticeable fraction of its inputs. Our proof technique is based on tools from extremal graph theory applied to the \\'collision graph\\' induced by the extractor, and may be of independent interest. We discuss possible applications to the theory of randomness extractors and non-malleable codes."}],"intvolume":"      2018","year":"2018","external_id":{"isi":["000448139300368"]},"quality_controlled":"1","isi":1,"scopus_import":"1","publisher":"IEEE","fulldoi":"https://doi.org/10.1109/ISIT.2018.8437654","_id":"108","oa":1,"department":[{"_id":"KrPi"}],"article_processing_charge":"No","citation":{"chicago":"Obremski, Marciej, and Maciej Skórski. “Inverted Leftover Hash Lemma,” Vol. 2018. IEEE, 2018. <a href=\"https://doi.org/10.1109/ISIT.2018.8437654\">https://doi.org/10.1109/ISIT.2018.8437654</a>.","ama":"Obremski M, Skórski M. Inverted leftover hash lemma. In: Vol 2018. IEEE; 2018. doi:<a href=\"https://doi.org/10.1109/ISIT.2018.8437654\">10.1109/ISIT.2018.8437654</a>","short":"M. Obremski, M. Skórski, in:, IEEE, 2018.","mla":"Obremski, Marciej, and Maciej Skórski. <i>Inverted Leftover Hash Lemma</i>. Vol. 2018, IEEE, 2018, doi:<a href=\"https://doi.org/10.1109/ISIT.2018.8437654\">10.1109/ISIT.2018.8437654</a>.","ista":"Obremski M, Skórski M. 2018. Inverted leftover hash lemma. ISIT: International Symposium on Information Theory, ISIT Proceedings, vol. 2018.","apa":"Obremski, M., &#38; Skórski, M. (2018). Inverted leftover hash lemma (Vol. 2018). Presented at the ISIT: International Symposium on Information Theory, Vail, CO, USA: IEEE. <a href=\"https://doi.org/10.1109/ISIT.2018.8437654\">https://doi.org/10.1109/ISIT.2018.8437654</a>","ieee":"M. Obremski and M. Skórski, “Inverted leftover hash lemma,” presented at the ISIT: International Symposium on Information Theory, Vail, CO, USA, 2018, vol. 2018."},"volume":2018,"month":"08","publication_status":"published","date_published":"2018-08-16T00:00:00Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"isi":1,"quality_controlled":"1","external_id":{"isi":["000475627800005"]},"year":"2018","abstract":[{"text":"Consider a fully-connected synchronous distributed system consisting of n nodes, where up to f nodes may be faulty and every node starts in an arbitrary initial state. In the synchronous C-counting problem, all nodes need to eventually agree on a counter that is increased by one modulo C in each round for given C&gt;1. In the self-stabilising firing squad problem, the task is to eventually guarantee that all non-faulty nodes have simultaneous responses to external inputs: if a subset of the correct nodes receive an external “go” signal as input, then all correct nodes should agree on a round (in the not-too-distant future) in which to jointly output a “fire” signal. Moreover, no node should generate a “fire” signal without some correct node having previously received a “go” signal as input. We present a framework reducing both tasks to binary consensus at very small cost. For example, we obtain a deterministic algorithm for self-stabilising Byzantine firing squads with optimal resilience f&lt;n/3, asymptotically optimal stabilisation and response time O(f), and message size O(log f). As our framework does not restrict the type of consensus routines used, we also obtain efficient randomised solutions.","lang":"eng"}],"file":[{"file_size":799337,"relation":"main_file","access_level":"open_access","date_updated":"2020-07-14T12:48:01Z","file_name":"2018_DistributedComputing_Lenzen.pdf","date_created":"2018-12-17T14:21:22Z","checksum":"872db70bba9b401500abe3c6ae2f1a61","creator":"dernst","content_type":"application/pdf","file_id":"5711"}],"day":"12","date_updated":"2025-04-15T06:53:15Z","title":"Near-optimal self-stabilising counting and firing squads","publist_id":"7978","oa_version":"Published Version","language":[{"iso":"eng"}],"type":"journal_article","status":"public","file_date_updated":"2020-07-14T12:48:01Z","doi":"10.1007/s00446-018-0342-6","date_created":"2018-12-11T11:44:30Z","author":[{"last_name":"Lenzen","first_name":"Christoph","full_name":"Lenzen, Christoph"},{"full_name":"Rybicki, Joel","id":"334EFD2E-F248-11E8-B48F-1D18A9856A87","first_name":"Joel","last_name":"Rybicki","orcid":"0000-0002-6432-6646"}],"ddc":["000"],"corr_author":"1","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_published":"2018-09-12T00:00:00Z","publication_status":"published","month":"09","citation":{"ama":"Lenzen C, Rybicki J. Near-optimal self-stabilising counting and firing squads. <i>Distributed Computing</i>. 2018. doi:<a href=\"https://doi.org/10.1007/s00446-018-0342-6\">10.1007/s00446-018-0342-6</a>","chicago":"Lenzen, Christoph, and Joel Rybicki. “Near-Optimal Self-Stabilising Counting and Firing Squads.” <i>Distributed Computing</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s00446-018-0342-6\">https://doi.org/10.1007/s00446-018-0342-6</a>.","ieee":"C. Lenzen and J. Rybicki, “Near-optimal self-stabilising counting and firing squads,” <i>Distributed Computing</i>. Springer, 2018.","ista":"Lenzen C, Rybicki J. 2018. Near-optimal self-stabilising counting and firing squads. Distributed Computing.","apa":"Lenzen, C., &#38; Rybicki, J. (2018). Near-optimal self-stabilising counting and firing squads. <i>Distributed Computing</i>. Springer. <a href=\"https://doi.org/10.1007/s00446-018-0342-6\">https://doi.org/10.1007/s00446-018-0342-6</a>","mla":"Lenzen, Christoph, and Joel Rybicki. “Near-Optimal Self-Stabilising Counting and Firing Squads.” <i>Distributed Computing</i>, Springer, 2018, doi:<a href=\"https://doi.org/10.1007/s00446-018-0342-6\">10.1007/s00446-018-0342-6</a>.","short":"C. Lenzen, J. Rybicki, Distributed Computing (2018)."},"article_processing_charge":"Yes (via OA deal)","department":[{"_id":"DaAl"}],"oa":1,"has_accepted_license":"1","project":[{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"publication":"Distributed Computing","_id":"76","fulldoi":"https://doi.org/10.1007/s00446-018-0342-6","scopus_import":"1","publisher":"Springer"},{"fulldoi":"https://doi.org/10.1016/j.neuron.2017.12.029","author":[{"last_name":"Sweeney","orcid":"0000-0001-9242-5601","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","first_name":"Lora Beatrice Jaeger","full_name":"Sweeney, Lora Beatrice Jaeger"},{"full_name":"Bikoff, Jay B.","first_name":"Jay B.","last_name":"Bikoff"},{"last_name":"Gabitto","first_name":"Mariano I.","full_name":"Gabitto, Mariano I."},{"full_name":"Brenner-Morton, Susan","first_name":"Susan","last_name":"Brenner-Morton"},{"last_name":"Baek","first_name":"Myungin","full_name":"Baek, Myungin"},{"full_name":"Yang, Jerry H.","first_name":"Jerry H.","last_name":"Yang"},{"full_name":"Tabak, Esteban G.","last_name":"Tabak","first_name":"Esteban G."},{"full_name":"Dasen, Jeremy S.","last_name":"Dasen","first_name":"Jeremy S."},{"last_name":"Kintner","first_name":"Christopher R.","full_name":"Kintner, Christopher R."},{"first_name":"Thomas M.","last_name":"Jessell","full_name":"Jessell, Thomas M."}],"publisher":"Elsevier","date_created":"2020-04-30T10:35:13Z","publication":"Neuron","publication_identifier":{"issn":["0896-6273"]},"_id":"7698","issue":"2","type":"journal_article","doi":"10.1016/j.neuron.2017.12.029","status":"public","extern":"1","date_updated":"2024-01-31T10:13:54Z","title":"Origin and segmental diversity of spinal inhibitory interneurons","article_processing_charge":"No","day":"04","oa_version":"None","language":[{"iso":"eng"}],"intvolume":"        97","volume":97,"citation":{"ieee":"L. B. Sweeney <i>et al.</i>, “Origin and segmental diversity of spinal inhibitory interneurons,” <i>Neuron</i>, vol. 97, no. 2. Elsevier, p. 341–355.e3, 2018.","short":"L.B. Sweeney, J.B. Bikoff, M.I. Gabitto, S. Brenner-Morton, M. Baek, J.H. Yang, E.G. Tabak, J.S. Dasen, C.R. Kintner, T.M. Jessell, Neuron 97 (2018) 341–355.e3.","apa":"Sweeney, L. B., Bikoff, J. B., Gabitto, M. I., Brenner-Morton, S., Baek, M., Yang, J. H., … Jessell, T. M. (2018). Origin and segmental diversity of spinal inhibitory interneurons. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2017.12.029\">https://doi.org/10.1016/j.neuron.2017.12.029</a>","ista":"Sweeney LB, Bikoff JB, Gabitto MI, Brenner-Morton S, Baek M, Yang JH, Tabak EG, Dasen JS, Kintner CR, Jessell TM. 2018. Origin and segmental diversity of spinal inhibitory interneurons. Neuron. 97(2), 341–355.e3.","mla":"Sweeney, Lora B., et al. “Origin and Segmental Diversity of Spinal Inhibitory Interneurons.” <i>Neuron</i>, vol. 97, no. 2, Elsevier, 2018, p. 341–355.e3, doi:<a href=\"https://doi.org/10.1016/j.neuron.2017.12.029\">10.1016/j.neuron.2017.12.029</a>.","chicago":"Sweeney, Lora B., Jay B. Bikoff, Mariano I. Gabitto, Susan Brenner-Morton, Myungin Baek, Jerry H. Yang, Esteban G. Tabak, Jeremy S. Dasen, Christopher R. Kintner, and Thomas M. Jessell. “Origin and Segmental Diversity of Spinal Inhibitory Interneurons.” <i>Neuron</i>. Elsevier, 2018. <a href=\"https://doi.org/10.1016/j.neuron.2017.12.029\">https://doi.org/10.1016/j.neuron.2017.12.029</a>.","ama":"Sweeney LB, Bikoff JB, Gabitto MI, et al. Origin and segmental diversity of spinal inhibitory interneurons. <i>Neuron</i>. 2018;97(2):341-355.e3. doi:<a href=\"https://doi.org/10.1016/j.neuron.2017.12.029\">10.1016/j.neuron.2017.12.029</a>"},"abstract":[{"text":"Motor output varies along the rostro-caudal axis of the tetrapod spinal cord. At limb levels, ∼60 motor pools control the alternation of flexor and extensor muscles about each joint, whereas at thoracic levels as few as 10 motor pools supply muscle groups that support posture, inspiration, and expiration. Whether such differences in motor neuron identity and muscle number are associated with segmental distinctions in interneuron diversity has not been resolved. We show that select combinations of nineteen transcription factors that specify lumbar V1 inhibitory interneurons generate subpopulations enriched at limb and thoracic levels. Specification of limb and thoracic V1 interneurons involves the Hox gene Hoxc9 independently of motor neurons. Thus, early Hox patterning of the spinal cord determines the identity of V1 interneurons and motor neurons. These studies reveal a developmental program of V1 interneuron diversity, providing insight into the organization of inhibitory interneurons associated with differential motor output.","lang":"eng"}],"date_published":"2018-01-04T00:00:00Z","publication_status":"published","year":"2018","month":"01","page":"341-355.e3","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","article_type":"original"},{"_id":"77","publication":"Nature Communications","publisher":"Nature Publishing Group","scopus_import":"1","fulldoi":"https://doi.org/10.1038/s41467-018-06418-4","has_accepted_license":"1","oa":1,"project":[{"name":"Towards Spin qubits and Majorana fermions in Germanium self assembled hut-wires","grant_number":"335497","call_identifier":"FP7","_id":"25517E86-B435-11E9-9278-68D0E5697425"},{"_id":"2552F888-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"Y00715","name":"Loch Spin-Qubits und Majorana-Fermionen in Germanium"}],"citation":{"short":"H. Watzinger, J. Kukucka, L. Vukušić, F. Gao, T. Wang, F. Schäffler, J. Zhang, G. Katsaros, Nature Communications 9 (2018).","mla":"Watzinger, Hannes, et al. “A Germanium Hole Spin Qubit.” <i>Nature Communications</i>, vol. 9, no. 3902, Nature Publishing Group, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-06418-4\">10.1038/s41467-018-06418-4</a>.","apa":"Watzinger, H., Kukucka, J., Vukušić, L., Gao, F., Wang, T., Schäffler, F., … Katsaros, G. (2018). A germanium hole spin qubit. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-018-06418-4\">https://doi.org/10.1038/s41467-018-06418-4</a>","ista":"Watzinger H, Kukucka J, Vukušić L, Gao F, Wang T, Schäffler F, Zhang J, Katsaros G. 2018. A germanium hole spin qubit. Nature Communications. 9(3902).","ieee":"H. Watzinger <i>et al.</i>, “A germanium hole spin qubit,” <i>Nature Communications</i>, vol. 9, no. 3902. Nature Publishing Group, 2018.","ama":"Watzinger H, Kukucka J, Vukušić L, et al. A germanium hole spin qubit. <i>Nature Communications</i>. 2018;9(3902). doi:<a href=\"https://doi.org/10.1038/s41467-018-06418-4\">10.1038/s41467-018-06418-4</a>","chicago":"Watzinger, Hannes, Josip Kukucka, Lada Vukušić, Fei Gao, Ting Wang, Friedrich Schäffler, Jian Zhang, and Georgios Katsaros. “A Germanium Hole Spin Qubit.” <i>Nature Communications</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41467-018-06418-4\">https://doi.org/10.1038/s41467-018-06418-4</a>."},"ec_funded":1,"volume":9,"article_processing_charge":"Yes","department":[{"_id":"GeKa"}],"related_material":{"record":[{"relation":"popular_science","id":"7977"},{"relation":"dissertation_contains","status":"public","id":"7996"}]},"article_type":"original","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","month":"09","date_published":"2018-09-25T00:00:00Z","publication_status":"published","issue":"3902 ","date_created":"2018-12-11T11:44:30Z","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"ddc":["530"],"author":[{"last_name":"Watzinger","first_name":"Hannes","id":"35DF8E50-F248-11E8-B48F-1D18A9856A87","full_name":"Watzinger, Hannes"},{"last_name":"Kukucka","id":"3F5D8856-F248-11E8-B48F-1D18A9856A87","first_name":"Josip","full_name":"Kukucka, Josip"},{"full_name":"Vukusic, Lada","id":"31E9F056-F248-11E8-B48F-1D18A9856A87","first_name":"Lada","orcid":"0000-0003-2424-8636","last_name":"Vukusic"},{"last_name":"Gao","first_name":"Fei","full_name":"Gao, Fei"},{"first_name":"Ting","last_name":"Wang","full_name":"Wang, Ting"},{"last_name":"Schäffler","first_name":"Friedrich","full_name":"Schäffler, Friedrich"},{"full_name":"Zhang, Jian","first_name":"Jian","last_name":"Zhang"},{"last_name":"Katsaros","orcid":"0000-0001-8342-202X","first_name":"Georgios","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","full_name":"Katsaros, Georgios"}],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"doi":"10.1038/s41467-018-06418-4","file_date_updated":"2020-07-14T12:48:02Z","status":"public","type":"journal_article","file":[{"relation":"main_file","file_size":1063469,"file_id":"5687","checksum":"e7148c10a64497e279c4de570b6cc544","creator":"dernst","content_type":"application/pdf","date_created":"2018-12-17T10:28:30Z","file_name":"2018_NatureComm_Watzinger.pdf","date_updated":"2020-07-14T12:48:02Z","access_level":"open_access"}],"abstract":[{"lang":"eng","text":"Holes confined in quantum dots have gained considerable interest in the past few years due to their potential as spin qubits. Here we demonstrate two-axis control of a spin 3/2 qubit in natural Ge. The qubit is formed in a hut wire double quantum dot device. The Pauli spin blockade principle allowed us to demonstrate electric dipole spin resonance by applying a radio frequency electric field to one of the electrodes defining the double quantum dot. Coherent hole spin oscillations with Rabi frequencies reaching 140 MHz are demonstrated and dephasing times of 130 ns are measured. The reported results emphasize the potential of Ge as a platform for fast and electrically tunable hole spin qubit devices."}],"intvolume":"         9","oa_version":"Published Version","language":[{"iso":"eng"}],"date_updated":"2026-04-08T07:27:13Z","title":"A germanium hole spin qubit","day":"25","quality_controlled":"1","isi":1,"year":"2018","external_id":{"isi":["000445560800010"]}},{"status":"public","doi":"10.1038/s41467-018-07862-y","type":"journal_article","author":[{"full_name":"Yap, Chloe X.","first_name":"Chloe X.","last_name":"Yap"},{"last_name":"Sidorenko","first_name":"Julia","full_name":"Sidorenko, Julia"},{"full_name":"Wu, Yang","first_name":"Yang","last_name":"Wu"},{"full_name":"Kemper, Kathryn E.","last_name":"Kemper","first_name":"Kathryn E."},{"last_name":"Yang","first_name":"Jian","full_name":"Yang, Jian"},{"full_name":"Wray, Naomi R.","last_name":"Wray","first_name":"Naomi R."},{"full_name":"Robinson, Matthew Richard","first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","last_name":"Robinson","orcid":"0000-0001-8982-8813"},{"last_name":"Visscher","first_name":"Peter M.","full_name":"Visscher, Peter M."}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-018-07862-y"}],"date_created":"2020-04-30T10:41:19Z","year":"2018","quality_controlled":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"date_updated":"2021-01-12T08:15:02Z","title":"Dissection of genetic variation and evidence for pleiotropy in male pattern baldness","day":"20","article_number":"5407","abstract":[{"text":"Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.01) from conventionally-unrelated males. We detect 624 near-independent genome-wide loci, contributing SNP-heritability of 0.25 (SE = 0.01), of which 26 X-chromosome loci explain 11.6%. Autosomal genetic variance is enriched for common variants and regions of lower linkage disequilibrium. We identify plausible genetic correlations between MPB and multiple sex-limited markers of earlier puberty, increased bone mineral density (rg = 0.15) and pancreatic β-cell function (rg = 0.12). Correlations with reproductive traits imply an effect on fitness, consistent with an estimated linear selection gradient of -0.018 per MPB standard deviation. Overall, we provide genetic insights into MPB: a phenotype of interest in its own right, with value as a model sex-limited, complex trait.","lang":"eng"}],"intvolume":"         9","extern":"1","oa":1,"publisher":"Springer Nature","fulldoi":"https://doi.org/10.1038/s41467-018-07862-y","publication_identifier":{"issn":["2041-1723"]},"_id":"7712","publication":"Nature Communications","month":"12","publication_status":"published","date_published":"2018-12-20T00:00:00Z","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","citation":{"apa":"Yap, C. X., Sidorenko, J., Wu, Y., Kemper, K. E., Yang, J., Wray, N. R., … Visscher, P. M. (2018). Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-018-07862-y\">https://doi.org/10.1038/s41467-018-07862-y</a>","ista":"Yap CX, Sidorenko J, Wu Y, Kemper KE, Yang J, Wray NR, Robinson MR, Visscher PM. 2018. Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. Nature Communications. 9, 5407.","mla":"Yap, Chloe X., et al. “Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness.” <i>Nature Communications</i>, vol. 9, 5407, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-07862-y\">10.1038/s41467-018-07862-y</a>.","short":"C.X. Yap, J. Sidorenko, Y. Wu, K.E. Kemper, J. Yang, N.R. Wray, M.R. Robinson, P.M. Visscher, Nature Communications 9 (2018).","ieee":"C. X. Yap <i>et al.</i>, “Dissection of genetic variation and evidence for pleiotropy in male pattern baldness,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","ama":"Yap CX, Sidorenko J, Wu Y, et al. Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-018-07862-y\">10.1038/s41467-018-07862-y</a>","chicago":"Yap, Chloe X., Julia Sidorenko, Yang Wu, Kathryn E. Kemper, Jian Yang, Naomi R. Wray, Matthew Richard Robinson, and Peter M. Visscher. “Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-018-07862-y\">https://doi.org/10.1038/s41467-018-07862-y</a>."},"volume":9},{"article_processing_charge":"No","volume":9,"citation":{"chicago":"Guo, Jing, Yang Wu, Zhihong Zhu, Zhili Zheng, Maciej Trzaskowski, Jian Zeng, Matthew Richard Robinson, Peter M. Visscher, and Jian Yang. “Global Genetic Differentiation of Complex Traits Shaped by Natural Selection in Humans.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-018-04191-y\">https://doi.org/10.1038/s41467-018-04191-y</a>.","ama":"Guo J, Wu Y, Zhu Z, et al. Global genetic differentiation of complex traits shaped by natural selection in humans. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-018-04191-y\">10.1038/s41467-018-04191-y</a>","short":"J. Guo, Y. Wu, Z. Zhu, Z. Zheng, M. Trzaskowski, J. Zeng, M.R. Robinson, P.M. Visscher, J. Yang, Nature Communications 9 (2018).","apa":"Guo, J., Wu, Y., Zhu, Z., Zheng, Z., Trzaskowski, M., Zeng, J., … Yang, J. (2018). Global genetic differentiation of complex traits shaped by natural selection in humans. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-018-04191-y\">https://doi.org/10.1038/s41467-018-04191-y</a>","ista":"Guo J, Wu Y, Zhu Z, Zheng Z, Trzaskowski M, Zeng J, Robinson MR, Visscher PM, Yang J. 2018. Global genetic differentiation of complex traits shaped by natural selection in humans. Nature Communications. 9, 1865.","mla":"Guo, Jing, et al. “Global Genetic Differentiation of Complex Traits Shaped by Natural Selection in Humans.” <i>Nature Communications</i>, vol. 9, 1865, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-04191-y\">10.1038/s41467-018-04191-y</a>.","ieee":"J. Guo <i>et al.</i>, “Global genetic differentiation of complex traits shaped by natural selection in humans,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018."},"publication_status":"published","date_published":"2018-05-14T00:00:00Z","month":"05","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","fulldoi":"https://doi.org/10.1038/s41467-018-04191-y","publisher":"Springer Nature","publication":"Nature Communications","_id":"7713","publication_identifier":{"issn":["2041-1723"]},"oa":1,"extern":"1","day":"14","date_updated":"2021-01-12T08:15:02Z","title":"Global genetic differentiation of complex traits shaped by natural selection in humans","oa_version":"Published Version","language":[{"iso":"eng"}],"intvolume":"         9","article_number":"1865","abstract":[{"lang":"eng","text":"There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to ~405,000). We show that SNPs associated with height (P=2.46×10−5), waist-to-hip ratio (P=2.77×10−4), and schizophrenia (P=3.96×10−5) are significantly more differentiated among populations than matched “control” SNPs, suggesting that these trait-associated SNPs have undergone natural selection. We further find that SNPs associated with height (P=2.01×10−6) and schizophrenia (P=5.16×10−18) show significantly higher variance in linkage disequilibrium (LD) scores across populations than control SNPs. Our results support the hypothesis that natural selection has shaped the genetic differentiation of complex traits, such as height and schizophrenia, among worldwide populations."}],"year":"2018","quality_controlled":"1","author":[{"full_name":"Guo, Jing","first_name":"Jing","last_name":"Guo"},{"full_name":"Wu, Yang","last_name":"Wu","first_name":"Yang"},{"first_name":"Zhihong","last_name":"Zhu","full_name":"Zhu, Zhihong"},{"full_name":"Zheng, Zhili","first_name":"Zhili","last_name":"Zheng"},{"full_name":"Trzaskowski, Maciej","first_name":"Maciej","last_name":"Trzaskowski"},{"full_name":"Zeng, Jian","last_name":"Zeng","first_name":"Jian"},{"first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","last_name":"Robinson","orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard"},{"first_name":"Peter M.","last_name":"Visscher","full_name":"Visscher, Peter M."},{"full_name":"Yang, Jian","last_name":"Yang","first_name":"Jian"}],"date_created":"2020-04-30T10:41:36Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-018-04191-y"}],"type":"journal_article","doi":"10.1038/s41467-018-04191-y","status":"public"},{"article_processing_charge":"No","citation":{"ieee":"Z. Zhu <i>et al.</i>, “Causal associations between risk factors and common diseases inferred from GWAS summary data,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","apa":"Zhu, Z., Zheng, Z., Zhang, F., Wu, Y., Trzaskowski, M., Maier, R., … Yang, J. (2018). Causal associations between risk factors and common diseases inferred from GWAS summary data. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-017-02317-2\">https://doi.org/10.1038/s41467-017-02317-2</a>","mla":"Zhu, Zhihong, et al. “Causal Associations between Risk Factors and Common Diseases Inferred from GWAS Summary Data.” <i>Nature Communications</i>, vol. 9, 224, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-017-02317-2\">10.1038/s41467-017-02317-2</a>.","ista":"Zhu Z, Zheng Z, Zhang F, Wu Y, Trzaskowski M, Maier R, Robinson MR, McGrath JJ, Visscher PM, Wray NR, Yang J. 2018. Causal associations between risk factors and common diseases inferred from GWAS summary data. Nature Communications. 9, 224.","short":"Z. Zhu, Z. Zheng, F. Zhang, Y. Wu, M. Trzaskowski, R. Maier, M.R. Robinson, J.J. McGrath, P.M. Visscher, N.R. Wray, J. Yang, Nature Communications 9 (2018).","chicago":"Zhu, Zhihong, Zhili Zheng, Futao Zhang, Yang Wu, Maciej Trzaskowski, Robert Maier, Matthew Richard Robinson, et al. “Causal Associations between Risk Factors and Common Diseases Inferred from GWAS Summary Data.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-017-02317-2\">https://doi.org/10.1038/s41467-017-02317-2</a>.","ama":"Zhu Z, Zheng Z, Zhang F, et al. Causal associations between risk factors and common diseases inferred from GWAS summary data. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-017-02317-2\">10.1038/s41467-017-02317-2</a>"},"volume":9,"month":"01","publication_status":"published","date_published":"2018-01-15T00:00:00Z","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","fulldoi":"https://doi.org/10.1038/s41467-017-02317-2","_id":"7714","publication_identifier":{"issn":["2041-1723"]},"publication":"Nature Communications","extern":"1","oa":1,"oa_version":"Published Version","language":[{"iso":"eng"}],"day":"15","date_updated":"2021-01-12T08:15:03Z","title":"Causal associations between risk factors and common diseases inferred from GWAS summary data","abstract":[{"lang":"eng","text":"Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a multi-SNP Mendelian randomization analysis using summary-level data from genome-wide association studies to test the causal associations of BMI, waist-to-hip ratio, serum cholesterols, blood pressures, height, and years of schooling (EduYears) with common diseases (sample sizes of up to 405,072). We identify a number of causal associations including a protective effect of LDL-cholesterol against type-2 diabetes (T2D) that might explain the side effects of statins on T2D, a protective effect of EduYears against Alzheimer’s disease, and bidirectional associations with opposite effects (e.g., higher BMI increases the risk of T2D but the effect of T2D on BMI is negative)."}],"article_number":"224","intvolume":"         9","year":"2018","quality_controlled":"1","author":[{"first_name":"Zhihong","last_name":"Zhu","full_name":"Zhu, Zhihong"},{"last_name":"Zheng","first_name":"Zhili","full_name":"Zheng, Zhili"},{"last_name":"Zhang","first_name":"Futao","full_name":"Zhang, Futao"},{"full_name":"Wu, Yang","first_name":"Yang","last_name":"Wu"},{"last_name":"Trzaskowski","first_name":"Maciej","full_name":"Trzaskowski, Maciej"},{"first_name":"Robert","last_name":"Maier","full_name":"Maier, Robert"},{"first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","orcid":"0000-0001-8982-8813","last_name":"Robinson","full_name":"Robinson, Matthew Richard"},{"full_name":"McGrath, John J.","first_name":"John J.","last_name":"McGrath"},{"full_name":"Visscher, Peter M.","last_name":"Visscher","first_name":"Peter M."},{"full_name":"Wray, Naomi R.","last_name":"Wray","first_name":"Naomi R."},{"last_name":"Yang","first_name":"Jian","full_name":"Yang, Jian"}],"main_file_link":[{"url":"https://doi.org/10.1038/s41467-017-02317-2","open_access":"1"}],"date_created":"2020-04-30T10:41:55Z","doi":"10.1038/s41467-017-02317-2","status":"public","type":"journal_article"},{"date_updated":"2021-01-12T08:15:03Z","title":"Imprint of assortative mating on the human genome","day":"26","article_processing_charge":"No","oa_version":"None","language":[{"iso":"eng"}],"intvolume":"         2","volume":2,"citation":{"ieee":"L. Yengo <i>et al.</i>, “Imprint of assortative mating on the human genome,” <i>Nature Human Behaviour</i>, vol. 2, no. 12. Springer Nature, pp. 948–954, 2018.","short":"L. Yengo, M.R. Robinson, M.C. Keller, K.E. Kemper, Y. Yang, M. Trzaskowski, J. Gratten, P. Turley, D. Cesarini, D.J. Benjamin, N.R. Wray, M.E. Goddard, J. Yang, P.M. Visscher, Nature Human Behaviour 2 (2018) 948–954.","apa":"Yengo, L., Robinson, M. R., Keller, M. C., Kemper, K. E., Yang, Y., Trzaskowski, M., … Visscher, P. M. (2018). Imprint of assortative mating on the human genome. <i>Nature Human Behaviour</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41562-018-0476-3\">https://doi.org/10.1038/s41562-018-0476-3</a>","ista":"Yengo L, Robinson MR, Keller MC, Kemper KE, Yang Y, Trzaskowski M, Gratten J, Turley P, Cesarini D, Benjamin DJ, Wray NR, Goddard ME, Yang J, Visscher PM. 2018. Imprint of assortative mating on the human genome. Nature Human Behaviour. 2(12), 948–954.","mla":"Yengo, Loic, et al. “Imprint of Assortative Mating on the Human Genome.” <i>Nature Human Behaviour</i>, vol. 2, no. 12, Springer Nature, 2018, pp. 948–54, doi:<a href=\"https://doi.org/10.1038/s41562-018-0476-3\">10.1038/s41562-018-0476-3</a>.","chicago":"Yengo, Loic, Matthew Richard Robinson, Matthew C. Keller, Kathryn E. Kemper, Yuanhao Yang, Maciej Trzaskowski, Jacob Gratten, et al. “Imprint of Assortative Mating on the Human Genome.” <i>Nature Human Behaviour</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41562-018-0476-3\">https://doi.org/10.1038/s41562-018-0476-3</a>.","ama":"Yengo L, Robinson MR, Keller MC, et al. Imprint of assortative mating on the human genome. <i>Nature Human Behaviour</i>. 2018;2(12):948-954. doi:<a href=\"https://doi.org/10.1038/s41562-018-0476-3\">10.1038/s41562-018-0476-3</a>"},"abstract":[{"lang":"eng","text":"Preference for mates with similar phenotypes; that is, assortative mating, is widely observed in humans1,2,3,4,5 and has evolutionary consequences6,7,8. Under Fisher's classical theory6, assortative mating is predicted to induce a signature in the genome at trait-associated loci that can be detected and quantified. Here, we develop and apply a method to quantify assortative mating on a specific trait by estimating the correlation (θ) between genetic predictors of the trait from single nucleotide polymorphisms on odd- versus even-numbered chromosomes. We show by theory and simulation that the effect of assortative mating can be quantified in the presence of population stratification. We applied this approach to 32 complex traits and diseases using single nucleotide polymorphism data from ~400,000 unrelated individuals of European ancestry. We found significant evidence of assortative mating for height (θ = 3.2%) and educational attainment (θ = 2.7%), both of which were consistent with theoretical predictions. Overall, our results imply that assortative mating involves multiple traits and affects the genomic architecture of loci that are associated with these traits, and that the consequence of mate choice can be detected from a random sample of genomes."}],"date_published":"2018-11-26T00:00:00Z","publication_status":"published","year":"2018","month":"11","page":"948-954","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","article_type":"original","fulldoi":"https://doi.org/10.1038/s41562-018-0476-3","author":[{"full_name":"Yengo, Loic","first_name":"Loic","last_name":"Yengo"},{"id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard"},{"first_name":"Matthew C.","last_name":"Keller","full_name":"Keller, Matthew C."},{"full_name":"Kemper, Kathryn E.","last_name":"Kemper","first_name":"Kathryn E."},{"full_name":"Yang, Yuanhao","first_name":"Yuanhao","last_name":"Yang"},{"full_name":"Trzaskowski, Maciej","first_name":"Maciej","last_name":"Trzaskowski"},{"full_name":"Gratten, Jacob","first_name":"Jacob","last_name":"Gratten"},{"full_name":"Turley, Patrick","last_name":"Turley","first_name":"Patrick"},{"last_name":"Cesarini","first_name":"David","full_name":"Cesarini, David"},{"full_name":"Benjamin, Daniel J.","last_name":"Benjamin","first_name":"Daniel J."},{"full_name":"Wray, Naomi R.","last_name":"Wray","first_name":"Naomi R."},{"full_name":"Goddard, Michael E.","last_name":"Goddard","first_name":"Michael E."},{"full_name":"Yang, Jian","last_name":"Yang","first_name":"Jian"},{"full_name":"Visscher, Peter M.","last_name":"Visscher","first_name":"Peter M."}],"publisher":"Springer Nature","date_created":"2020-04-30T10:42:12Z","publication":"Nature Human Behaviour","_id":"7715","publication_identifier":{"issn":["2397-3374"]},"issue":"12","type":"journal_article","status":"public","doi":"10.1038/s41562-018-0476-3","extern":"1"},{"citation":{"apa":"Maier, R. M., Zhu, Z., Lee, S. H., Trzaskowski, M., Ruderfer, D. M., Stahl, E. A., … Robinson, M. R. (2018). Improving genetic prediction by leveraging genetic correlations among human diseases and traits. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-017-02769-6\">https://doi.org/10.1038/s41467-017-02769-6</a>","ista":"Maier RM, Zhu Z, Lee SH, Trzaskowski M, Ruderfer DM, Stahl EA, Ripke S, Wray NR, Yang J, Visscher PM, Robinson MR. 2018. Improving genetic prediction by leveraging genetic correlations among human diseases and traits. Nature Communications. 9, 989.","mla":"Maier, Robert M., et al. “Improving Genetic Prediction by Leveraging Genetic Correlations among Human Diseases and Traits.” <i>Nature Communications</i>, vol. 9, 989, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-017-02769-6\">10.1038/s41467-017-02769-6</a>.","short":"R.M. Maier, Z. Zhu, S.H. Lee, M. Trzaskowski, D.M. Ruderfer, E.A. Stahl, S. Ripke, N.R. Wray, J. Yang, P.M. Visscher, M.R. Robinson, Nature Communications 9 (2018).","ieee":"R. M. Maier <i>et al.</i>, “Improving genetic prediction by leveraging genetic correlations among human diseases and traits,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","ama":"Maier RM, Zhu Z, Lee SH, et al. Improving genetic prediction by leveraging genetic correlations among human diseases and traits. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-017-02769-6\">10.1038/s41467-017-02769-6</a>","chicago":"Maier, Robert M., Zhihong Zhu, Sang Hong Lee, Maciej Trzaskowski, Douglas M. Ruderfer, Eli A. Stahl, Stephan Ripke, et al. “Improving Genetic Prediction by Leveraging Genetic Correlations among Human Diseases and Traits.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-017-02769-6\">https://doi.org/10.1038/s41467-017-02769-6</a>."},"volume":9,"article_processing_charge":"No","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"03","publication_status":"published","date_published":"2018-03-07T00:00:00Z","_id":"7716","publication_identifier":{"issn":["2041-1723"]},"publication":"Nature Communications","publisher":"Springer Nature","fulldoi":"https://doi.org/10.1038/s41467-017-02769-6","extern":"1","oa":1,"article_number":"989","abstract":[{"lang":"eng","text":"Genomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to demonstrate that widespread pleiotropy among phenotypes can be utilised to improve genomic risk prediction. We show how a genetic predictor can be created as a weighted index that combines published genome-wide association study (GWAS) summary statistics across many different traits. We apply this framework to predict risk of schizophrenia and bipolar disorder in the Psychiatric Genomics consortium data, finding substantial heterogeneity in prediction accuracy increases across cohorts. For six additional phenotypes in the UK Biobank data, we find increases in prediction accuracy ranging from 0.7% for height to 47% for type 2 diabetes, when using a multi-trait predictor that combines published summary statistics from multiple traits, as compared to a predictor based only on one trait."}],"intvolume":"         9","oa_version":"Published Version","language":[{"iso":"eng"}],"date_updated":"2021-01-12T08:15:03Z","title":"Improving genetic prediction by leveraging genetic correlations among human diseases and traits","day":"07","quality_controlled":"1","year":"2018","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-017-02769-6"}],"date_created":"2020-04-30T10:42:29Z","author":[{"full_name":"Maier, Robert M.","last_name":"Maier","first_name":"Robert M."},{"full_name":"Zhu, Zhihong","first_name":"Zhihong","last_name":"Zhu"},{"first_name":"Sang Hong","last_name":"Lee","full_name":"Lee, Sang Hong"},{"first_name":"Maciej","last_name":"Trzaskowski","full_name":"Trzaskowski, Maciej"},{"full_name":"Ruderfer, Douglas M.","first_name":"Douglas M.","last_name":"Ruderfer"},{"full_name":"Stahl, Eli A.","last_name":"Stahl","first_name":"Eli A."},{"full_name":"Ripke, Stephan","last_name":"Ripke","first_name":"Stephan"},{"full_name":"Wray, Naomi R.","first_name":"Naomi R.","last_name":"Wray"},{"full_name":"Yang, Jian","last_name":"Yang","first_name":"Jian"},{"full_name":"Visscher, Peter M.","first_name":"Peter M.","last_name":"Visscher"},{"full_name":"Robinson, Matthew Richard","first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","orcid":"0000-0001-8982-8813","last_name":"Robinson"}],"status":"public","doi":"10.1038/s41467-017-02769-6","type":"journal_article"},{"status":"public","doi":"10.1186/s13073-018-0585-7","type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1186/s13073-018-0585-7","open_access":"1"}],"issue":"1","date_created":"2020-04-30T10:42:50Z","author":[{"full_name":"Zhang, Qian","last_name":"Zhang","first_name":"Qian"},{"first_name":"Riccardo E","last_name":"Marioni","full_name":"Marioni, Riccardo E"},{"full_name":"Robinson, Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard"},{"full_name":"Higham, Jon","first_name":"Jon","last_name":"Higham"},{"first_name":"Duncan","last_name":"Sproul","full_name":"Sproul, Duncan"},{"full_name":"Wray, Naomi R","first_name":"Naomi R","last_name":"Wray"},{"full_name":"Deary, Ian J","last_name":"Deary","first_name":"Ian J"},{"full_name":"McRae, Allan F","first_name":"Allan F","last_name":"McRae"},{"last_name":"Visscher","first_name":"Peter M","full_name":"Visscher, Peter M"}],"quality_controlled":"1","year":"2018","article_number":"75","abstract":[{"lang":"eng","text":"Background: DNA methylation levels change along with age, but few studies have examined the variation in the rate of such changes between individuals.\r\nMethods: We performed a longitudinal analysis to quantify the variation in the rate of change of DNA methylation between individuals using whole blood DNA methylation array profiles collected at 2–4 time points (N = 2894) in 954 individuals (67–90 years).\r\nResults: After stringent quality control, we identified 1507 DNA methylation CpG sites (rsCpGs) with statistically significant variation in the rate of change (random slope) of DNA methylation among individuals in a mixed linear model analysis. Genes in the vicinity of these rsCpGs were found to be enriched in Homeobox transcription factors and the Wnt signalling pathway, both of which are related to ageing processes. Furthermore, we investigated the SNP effect on the random slope. We found that 4 out of 1507 rsCpGs had one significant (P < 5 × 10−8/1507) SNP effect and 343 rsCpGs had at least one SNP effect (436 SNP-probe pairs) reaching genome-wide significance (P < 5 × 10−8). Ninety-five percent of the significant (P < 5 × 10−8) SNPs are on different chromosomes from their corresponding probes.\r\nConclusions: We identified CpG sites that have variability in the rate of change of DNA methylation between individuals, and our results suggest a genetic basis of this variation. Genes around these CpG sites have been reported to be involved in the ageing process."}],"intvolume":"        10","oa_version":"Published Version","language":[{"iso":"eng"}],"day":"22","title":"Genotype effects contribute to variation in longitudinal methylome patterns in older people","date_updated":"2021-01-12T08:15:04Z","extern":"1","oa":1,"_id":"7717","publication_identifier":{"issn":["1756-994X"]},"publication":"Genome Medicine","publisher":"Springer Nature","fulldoi":"https://doi.org/10.1186/s13073-018-0585-7","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"10","publication_status":"published","date_published":"2018-10-22T00:00:00Z","citation":{"chicago":"Zhang, Qian, Riccardo E Marioni, Matthew Richard Robinson, Jon Higham, Duncan Sproul, Naomi R Wray, Ian J Deary, Allan F McRae, and Peter M Visscher. “Genotype Effects Contribute to Variation in Longitudinal Methylome Patterns in Older People.” <i>Genome Medicine</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1186/s13073-018-0585-7\">https://doi.org/10.1186/s13073-018-0585-7</a>.","ama":"Zhang Q, Marioni RE, Robinson MR, et al. Genotype effects contribute to variation in longitudinal methylome patterns in older people. <i>Genome Medicine</i>. 2018;10(1). doi:<a href=\"https://doi.org/10.1186/s13073-018-0585-7\">10.1186/s13073-018-0585-7</a>","mla":"Zhang, Qian, et al. “Genotype Effects Contribute to Variation in Longitudinal Methylome Patterns in Older People.” <i>Genome Medicine</i>, vol. 10, no. 1, 75, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1186/s13073-018-0585-7\">10.1186/s13073-018-0585-7</a>.","apa":"Zhang, Q., Marioni, R. E., Robinson, M. R., Higham, J., Sproul, D., Wray, N. R., … Visscher, P. M. (2018). Genotype effects contribute to variation in longitudinal methylome patterns in older people. <i>Genome Medicine</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s13073-018-0585-7\">https://doi.org/10.1186/s13073-018-0585-7</a>","ista":"Zhang Q, Marioni RE, Robinson MR, Higham J, Sproul D, Wray NR, Deary IJ, McRae AF, Visscher PM. 2018. Genotype effects contribute to variation in longitudinal methylome patterns in older people. Genome Medicine. 10(1), 75.","short":"Q. Zhang, R.E. Marioni, M.R. Robinson, J. Higham, D. Sproul, N.R. Wray, I.J. Deary, A.F. McRae, P.M. Visscher, Genome Medicine 10 (2018).","ieee":"Q. Zhang <i>et al.</i>, “Genotype effects contribute to variation in longitudinal methylome patterns in older people,” <i>Genome Medicine</i>, vol. 10, no. 1. Springer Nature, 2018."},"volume":10,"article_processing_charge":"No"},{"abstract":[{"text":"Flores Island, Indonesia, was inhabited by the small-bodied hominin species Homo floresiensis, which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where H. floresiensis was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores.","lang":"eng"}],"intvolume":"       361","language":[{"iso":"eng"}],"oa_version":"None","date_updated":"2021-01-12T08:15:04Z","title":"Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia","day":"03","quality_controlled":"1","page":"511-516","year":"2018","external_id":{"pmid":["30072539"]},"issue":"6401","date_created":"2020-04-30T10:43:24Z","author":[{"full_name":"Tucci, Serena","first_name":"Serena","last_name":"Tucci"},{"full_name":"Vohr, Samuel H.","last_name":"Vohr","first_name":"Samuel H."},{"last_name":"McCoy","first_name":"Rajiv C.","full_name":"McCoy, Rajiv C."},{"full_name":"Vernot, Benjamin","last_name":"Vernot","first_name":"Benjamin"},{"orcid":"0000-0001-8982-8813","last_name":"Robinson","first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","full_name":"Robinson, Matthew Richard"},{"first_name":"Chiara","last_name":"Barbieri","full_name":"Barbieri, Chiara"},{"full_name":"Nelson, Brad J.","last_name":"Nelson","first_name":"Brad J."},{"full_name":"Fu, Wenqing","last_name":"Fu","first_name":"Wenqing"},{"full_name":"Purnomo, Gludhug A.","last_name":"Purnomo","first_name":"Gludhug A."},{"full_name":"Sudoyo, Herawati","last_name":"Sudoyo","first_name":"Herawati"},{"full_name":"Eichler, Evan E.","first_name":"Evan E.","last_name":"Eichler"},{"last_name":"Barbujani","first_name":"Guido","full_name":"Barbujani, Guido"},{"first_name":"Peter M.","last_name":"Visscher","full_name":"Visscher, Peter M."},{"full_name":"Akey, Joshua M.","first_name":"Joshua M.","last_name":"Akey"},{"first_name":"Richard E.","last_name":"Green","full_name":"Green, Richard E."}],"status":"public","doi":"10.1126/science.aar8486","type":"journal_article","citation":{"ieee":"S. Tucci <i>et al.</i>, “Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia,” <i>Science</i>, vol. 361, no. 6401. American Association for the Advancement of Science, pp. 511–516, 2018.","short":"S. Tucci, S.H. Vohr, R.C. McCoy, B. Vernot, M.R. Robinson, C. Barbieri, B.J. Nelson, W. Fu, G.A. Purnomo, H. Sudoyo, E.E. Eichler, G. Barbujani, P.M. Visscher, J.M. Akey, R.E. Green, Science 361 (2018) 511–516.","apa":"Tucci, S., Vohr, S. H., McCoy, R. C., Vernot, B., Robinson, M. R., Barbieri, C., … Green, R. E. (2018). Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aar8486\">https://doi.org/10.1126/science.aar8486</a>","mla":"Tucci, Serena, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” <i>Science</i>, vol. 361, no. 6401, American Association for the Advancement of Science, 2018, pp. 511–16, doi:<a href=\"https://doi.org/10.1126/science.aar8486\">10.1126/science.aar8486</a>.","ista":"Tucci S, Vohr SH, McCoy RC, Vernot B, Robinson MR, Barbieri C, Nelson BJ, Fu W, Purnomo GA, Sudoyo H, Eichler EE, Barbujani G, Visscher PM, Akey JM, Green RE. 2018. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science. 361(6401), 511–516.","chicago":"Tucci, Serena, Samuel H. Vohr, Rajiv C. McCoy, Benjamin Vernot, Matthew Richard Robinson, Chiara Barbieri, Brad J. Nelson, et al. “Evolutionary History and Adaptation of a Human Pygmy Population of Flores Island, Indonesia.” <i>Science</i>. American Association for the Advancement of Science, 2018. <a href=\"https://doi.org/10.1126/science.aar8486\">https://doi.org/10.1126/science.aar8486</a>.","ama":"Tucci S, Vohr SH, McCoy RC, et al. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. <i>Science</i>. 2018;361(6401):511-516. doi:<a href=\"https://doi.org/10.1126/science.aar8486\">10.1126/science.aar8486</a>"},"volume":361,"article_processing_charge":"No","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"08","publication_status":"published","date_published":"2018-08-03T00:00:00Z","_id":"7718","publication_identifier":{"issn":["0036-8075","1095-9203"]},"pmid":1,"publication":"Science","publisher":"American Association for the Advancement of Science","fulldoi":"https://doi.org/10.1126/science.aar8486","extern":"1"}]