[{"publication_status":"published","page":"401-408","date_published":"2017-01-20T00:00:00Z","year":"2017","month":"01","_id":"7291","article_type":"original","status":"public","publisher":"Wiley","day":"20","date_created":"2020-01-15T12:15:29Z","intvolume":"        10","publication_identifier":{"issn":["1864-5631"]},"extern":"1","author":[{"last_name":"Schafzahl","first_name":"Lukas","full_name":"Schafzahl, Lukas"},{"full_name":"Hanzu, Ilie","first_name":"Ilie","last_name":"Hanzu"},{"last_name":"Wilkening","first_name":"Martin","full_name":"Wilkening, Martin"},{"orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander","last_name":"Freunberger"}],"citation":{"ista":"Schafzahl L, Hanzu I, Wilkening M, Freunberger SA. 2017. An electrolyte for reversible cycling of sodium metal and intercalation compounds. ChemSusChem. 10(2), 401–408.","ieee":"L. Schafzahl, I. Hanzu, M. Wilkening, and S. A. Freunberger, “An electrolyte for reversible cycling of sodium metal and intercalation compounds,” <i>ChemSusChem</i>, vol. 10, no. 2. Wiley, pp. 401–408, 2017.","chicago":"Schafzahl, Lukas, Ilie Hanzu, Martin Wilkening, and Stefan Alexander Freunberger. “An Electrolyte for Reversible Cycling of Sodium Metal and Intercalation Compounds.” <i>ChemSusChem</i>. Wiley, 2017. <a href=\"https://doi.org/10.1002/cssc.201601222\">https://doi.org/10.1002/cssc.201601222</a>.","apa":"Schafzahl, L., Hanzu, I., Wilkening, M., &#38; Freunberger, S. A. (2017). An electrolyte for reversible cycling of sodium metal and intercalation compounds. <i>ChemSusChem</i>. Wiley. <a href=\"https://doi.org/10.1002/cssc.201601222\">https://doi.org/10.1002/cssc.201601222</a>","ama":"Schafzahl L, Hanzu I, Wilkening M, Freunberger SA. An electrolyte for reversible cycling of sodium metal and intercalation compounds. <i>ChemSusChem</i>. 2017;10(2):401-408. doi:<a href=\"https://doi.org/10.1002/cssc.201601222\">10.1002/cssc.201601222</a>","short":"L. Schafzahl, I. Hanzu, M. Wilkening, S.A. Freunberger, ChemSusChem 10 (2017) 401–408.","mla":"Schafzahl, Lukas, et al. “An Electrolyte for Reversible Cycling of Sodium Metal and Intercalation Compounds.” <i>ChemSusChem</i>, vol. 10, no. 2, Wiley, 2017, pp. 401–08, doi:<a href=\"https://doi.org/10.1002/cssc.201601222\">10.1002/cssc.201601222</a>."},"oa_version":"None","doi":"10.1002/cssc.201601222","issue":"2","quality_controlled":"1","title":"An electrolyte for reversible cycling of sodium metal and intercalation compounds","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","volume":10,"type":"journal_article","date_updated":"2021-01-12T08:12:48Z","language":[{"iso":"eng"}],"abstract":[{"text":"Na battery chemistries show poor passivation behavior of low voltage Na storage compounds and Na metal with organic carbonate‐based electrolytes adopted from Li‐ion batteries. Therefore, a suitable electrolyte remains a major challenge for establishing Na batteries. Here we report highly concentrated sodium bis(fluorosulfonyl)imide (NaFSI) in dimethoxyethane (DME) electrolytes and investigate them for Na metal and hard carbon anodes and intercalation cathodes. For a DME/NaFSI ratio of 2, a stable passivation of anode materials was found owing to the formation of a stable solid electrolyte interface, which was characterized spectroscopically. This permitted non‐dentritic Na metal cycling with approximately 98 % coulombic efficiency as shown for up to 300 cycles. The NaFSI/DME electrolyte may enable Na‐metal anodes and allows for more reliable assessment of electrode materials in Na‐ion half‐cells, as is demonstrated by comparing half‐cell cycling of hard carbon anodes and Na3V2(PO4)3 cathodes with a widely used carbonate and the NaFSI/DME electrolyte.","lang":"eng"}],"publication":"ChemSusChem"},{"_id":"7292","article_type":"original","day":"31","publisher":"RSC","extern":"1","page":"6716-6729","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"type":"journal_article","volume":8,"date_updated":"2021-01-12T08:12:49Z","language":[{"iso":"eng"}],"abstract":[{"text":"Rechargeable Li–O2 batteries have amongst the highest formal energy and could store significantly more energy than other rechargeable batteries in practice if at least a large part of their promise could be realized. Realization, however, still faces many challenges than can only be overcome by fundamental understanding of the processes taking place. Here, we review recent advances in understanding the chemistry of the Li–O2 cathode and provide a perspective on dominant research needs. We put particular emphasis on issues that are often grossly misunderstood: realistic performance metrics and their reporting as well as identifying reversibility and quantitative measures to do so. Parasitic reactions are the prime obstacle for reversible cell operation and have recently been identified to be predominantly caused by singlet oxygen and not by reduced oxygen species as thought before. We discuss the far reaching implications of this finding on electrolyte and cathode stability, electrocatalysis, and future research needs.","lang":"eng"}],"citation":{"mla":"Mahne, Nika, et al. “Mechanism and Performance of Lithium–Oxygen Batteries – a Perspective.” <i>Chemical Science</i>, vol. 8, no. 10, RSC, 2017, pp. 6716–29, doi:<a href=\"https://doi.org/10.1039/c7sc02519j\">10.1039/c7sc02519j</a>.","short":"N. Mahne, O. Fontaine, M.O. Thotiyl, M. Wilkening, S.A. Freunberger, Chemical Science 8 (2017) 6716–6729.","ama":"Mahne N, Fontaine O, Thotiyl MO, Wilkening M, Freunberger SA. Mechanism and performance of lithium–oxygen batteries – a perspective. <i>Chemical Science</i>. 2017;8(10):6716-6729. doi:<a href=\"https://doi.org/10.1039/c7sc02519j\">10.1039/c7sc02519j</a>","apa":"Mahne, N., Fontaine, O., Thotiyl, M. O., Wilkening, M., &#38; Freunberger, S. A. (2017). Mechanism and performance of lithium–oxygen batteries – a perspective. <i>Chemical Science</i>. RSC. <a href=\"https://doi.org/10.1039/c7sc02519j\">https://doi.org/10.1039/c7sc02519j</a>","chicago":"Mahne, Nika, Olivier Fontaine, Musthafa Ottakam Thotiyl, Martin Wilkening, and Stefan Alexander Freunberger. “Mechanism and Performance of Lithium–Oxygen Batteries – a Perspective.” <i>Chemical Science</i>. RSC, 2017. <a href=\"https://doi.org/10.1039/c7sc02519j\">https://doi.org/10.1039/c7sc02519j</a>.","ieee":"N. Mahne, O. Fontaine, M. O. Thotiyl, M. Wilkening, and S. A. Freunberger, “Mechanism and performance of lithium–oxygen batteries – a perspective,” <i>Chemical Science</i>, vol. 8, no. 10. RSC, pp. 6716–6729, 2017.","ista":"Mahne N, Fontaine O, Thotiyl MO, Wilkening M, Freunberger SA. 2017. Mechanism and performance of lithium–oxygen batteries – a perspective. Chemical Science. 8(10), 6716–6729."},"issue":"10","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2017","month":"07","status":"public","date_created":"2020-01-15T12:15:42Z","publication_identifier":{"eissn":["2041-6539"],"issn":["2041-6520"]},"intvolume":"         8","author":[{"last_name":"Mahne","first_name":"Nika","full_name":"Mahne, Nika"},{"last_name":"Fontaine","first_name":"Olivier","full_name":"Fontaine, Olivier"},{"first_name":"Musthafa Ottakam","last_name":"Thotiyl","full_name":"Thotiyl, Musthafa Ottakam"},{"full_name":"Wilkening, Martin","first_name":"Martin","last_name":"Wilkening"},{"id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","last_name":"Freunberger","first_name":"Stefan Alexander"}],"publication_status":"published","date_published":"2017-07-31T00:00:00Z","article_processing_charge":"No","publication":"Chemical Science","file":[{"date_created":"2020-01-26T15:04:44Z","date_updated":"2020-07-14T12:47:55Z","access_level":"open_access","file_name":"2017_ChemicalScience_Mahne.pdf","checksum":"70c7c2ce5430b6e8605ccbf0275f1e80","file_size":992106,"content_type":"application/pdf","creator":"dernst","file_id":"7363","relation":"main_file"}],"ddc":["540"],"oa_version":"Published Version","file_date_updated":"2020-07-14T12:47:55Z","doi":"10.1039/c7sc02519j","quality_controlled":"1","title":"Mechanism and performance of lithium–oxygen batteries – a perspective"},{"publication":"Science Translational Medicine","article_processing_charge":"No","title":"The science of love in ASD and ADHD","quality_controlled":"1","scopus_import":"1","doi":"10.1126/scitranslmed.aap8168","oa_version":"None","author":[{"last_name":"Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178"}],"publication_identifier":{"issn":["1946-6234"]},"intvolume":"         9","publist_id":"6938","date_created":"2018-12-11T11:48:12Z","status":"public","month":"10","year":"2017","date_published":"2017-10-11T00:00:00Z","corr_author":"1","department":[{"_id":"GaNo"}],"publication_status":"published","abstract":[{"text":"Genetic variations in the oxytocin receptor gene affect patients with ASD and ADHD differently.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2025-07-10T11:54:29Z","volume":9,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"411","article_number":"eaap8168","citation":{"mla":"Novarino, Gaia. “The Science of Love in ASD and ADHD.” <i>Science Translational Medicine</i>, vol. 9, no. 411, eaap8168, American Association for the Advancement of Science, 2017, doi:<a href=\"https://doi.org/10.1126/scitranslmed.aap8168\">10.1126/scitranslmed.aap8168</a>.","short":"G. Novarino, Science Translational Medicine 9 (2017).","ama":"Novarino G. The science of love in ASD and ADHD. <i>Science Translational Medicine</i>. 2017;9(411). doi:<a href=\"https://doi.org/10.1126/scitranslmed.aap8168\">10.1126/scitranslmed.aap8168</a>","apa":"Novarino, G. (2017). The science of love in ASD and ADHD. <i>Science Translational Medicine</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/scitranslmed.aap8168\">https://doi.org/10.1126/scitranslmed.aap8168</a>","chicago":"Novarino, Gaia. “The Science of Love in ASD and ADHD.” <i>Science Translational Medicine</i>. American Association for the Advancement of Science, 2017. <a href=\"https://doi.org/10.1126/scitranslmed.aap8168\">https://doi.org/10.1126/scitranslmed.aap8168</a>.","ieee":"G. Novarino, “The science of love in ASD and ADHD,” <i>Science Translational Medicine</i>, vol. 9, no. 411. American Association for the Advancement of Science, 2017.","ista":"Novarino G. 2017. The science of love in ASD and ADHD. Science Translational Medicine. 9(411), eaap8168."},"day":"11","publisher":"American Association for the Advancement of Science","_id":"731"},{"day":"15","publisher":"Academic Press","_id":"733","page":"251 - 291","abstract":[{"text":"Let A and B be two N by N deterministic Hermitian matrices and let U be an N by N Haar distributed unitary matrix. It is well known that the spectral distribution of the sum H = A + UBU∗ converges weakly to the free additive convolution of the spectral distributions of A and B, as N tends to infinity. We establish the optimal convergence rate in the bulk of the spectrum.","lang":"eng"}],"language":[{"iso":"eng"}],"date_updated":"2025-06-04T10:13:45Z","volume":319,"type":"journal_article","oa":1,"project":[{"call_identifier":"FP7","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","name":"Random matrices, universality and disordered quantum systems"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"Z. Bao, L. Erdös, K. Schnelli, Advances in Mathematics 319 (2017) 251–291.","ama":"Bao Z, Erdös L, Schnelli K. Convergence rate for spectral distribution of addition of random matrices. <i>Advances in Mathematics</i>. 2017;319:251-291. doi:<a href=\"https://doi.org/10.1016/j.aim.2017.08.028\">10.1016/j.aim.2017.08.028</a>","mla":"Bao, Zhigang, et al. “Convergence Rate for Spectral Distribution of Addition of Random Matrices.” <i>Advances in Mathematics</i>, vol. 319, Academic Press, 2017, pp. 251–91, doi:<a href=\"https://doi.org/10.1016/j.aim.2017.08.028\">10.1016/j.aim.2017.08.028</a>.","ista":"Bao Z, Erdös L, Schnelli K. 2017. Convergence rate for spectral distribution of addition of random matrices. Advances in Mathematics. 319, 251–291.","apa":"Bao, Z., Erdös, L., &#38; Schnelli, K. (2017). Convergence rate for spectral distribution of addition of random matrices. <i>Advances in Mathematics</i>. Academic Press. <a href=\"https://doi.org/10.1016/j.aim.2017.08.028\">https://doi.org/10.1016/j.aim.2017.08.028</a>","chicago":"Bao, Zhigang, László Erdös, and Kevin Schnelli. “Convergence Rate for Spectral Distribution of Addition of Random Matrices.” <i>Advances in Mathematics</i>. Academic Press, 2017. <a href=\"https://doi.org/10.1016/j.aim.2017.08.028\">https://doi.org/10.1016/j.aim.2017.08.028</a>.","ieee":"Z. Bao, L. Erdös, and K. Schnelli, “Convergence rate for spectral distribution of addition of random matrices,” <i>Advances in Mathematics</i>, vol. 319. Academic Press, pp. 251–291, 2017."},"author":[{"id":"442E6A6C-F248-11E8-B48F-1D18A9856A87","full_name":"Bao, Zhigang","orcid":"0000-0003-3036-1475","last_name":"Bao","first_name":"Zhigang"},{"full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László"},{"id":"434AD0AE-F248-11E8-B48F-1D18A9856A87","full_name":"Schnelli, Kevin","orcid":"0000-0003-0954-3231","last_name":"Schnelli","first_name":"Kevin"}],"intvolume":"       319","publist_id":"6935","date_created":"2018-12-11T11:48:13Z","isi":1,"arxiv":1,"status":"public","month":"10","year":"2017","ec_funded":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1606.03076"}],"date_published":"2017-10-15T00:00:00Z","corr_author":"1","department":[{"_id":"LaEr"}],"publication_status":"published","publication":"Advances in Mathematics","acknowledgement":"Partially supported by ERC Advanced Grant RANMAT No. 338804, Hong Kong RGC grant ECS 26301517, and the Göran Gustafsson Foundation","article_processing_charge":"No","title":"Convergence rate for spectral distribution of addition of random matrices","quality_controlled":"1","scopus_import":"1","external_id":{"arxiv":["1606.03076"],"isi":["000412150400010"]},"oa_version":"Submitted Version","doi":"10.1016/j.aim.2017.08.028"},{"page":"3375 - 3393","day":"01","publisher":"Springer","_id":"736","issue":"8","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"apa":"Rubio, M., Matsui, K., Fukazawa, Y., Kamasawa, N., Harada, H., Itakura, M., … Shigemoto, R. (2017). The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells. <i>Brain Structure and Function</i>. Springer. <a href=\"https://doi.org/10.1007/s00429-017-1408-0\">https://doi.org/10.1007/s00429-017-1408-0</a>","chicago":"Rubio, María, Ko Matsui, Yugo Fukazawa, Naomi Kamasawa, Harumi Harada, Makoto Itakura, Elek Molnár, Manabu Abe, Kenji Sakimura, and Ryuichi Shigemoto. “The Number and Distribution of AMPA Receptor Channels Containing Fast Kinetic GluA3 and GluA4 Subunits at Auditory Nerve Synapses Depend on the Target Cells.” <i>Brain Structure and Function</i>. Springer, 2017. <a href=\"https://doi.org/10.1007/s00429-017-1408-0\">https://doi.org/10.1007/s00429-017-1408-0</a>.","ieee":"M. Rubio <i>et al.</i>, “The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells,” <i>Brain Structure and Function</i>, vol. 222, no. 8. Springer, pp. 3375–3393, 2017.","ista":"Rubio M, Matsui K, Fukazawa Y, Kamasawa N, Harada H, Itakura M, Molnár E, Abe M, Sakimura K, Shigemoto R. 2017. The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells. Brain Structure and Function. 222(8), 3375–3393.","mla":"Rubio, María, et al. “The Number and Distribution of AMPA Receptor Channels Containing Fast Kinetic GluA3 and GluA4 Subunits at Auditory Nerve Synapses Depend on the Target Cells.” <i>Brain Structure and Function</i>, vol. 222, no. 8, Springer, 2017, pp. 3375–93, doi:<a href=\"https://doi.org/10.1007/s00429-017-1408-0\">10.1007/s00429-017-1408-0</a>.","short":"M. Rubio, K. Matsui, Y. Fukazawa, N. Kamasawa, H. Harada, M. Itakura, E. Molnár, M. Abe, K. Sakimura, R. Shigemoto, Brain Structure and Function 222 (2017) 3375–3393.","ama":"Rubio M, Matsui K, Fukazawa Y, et al. The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells. <i>Brain Structure and Function</i>. 2017;222(8):3375-3393. doi:<a href=\"https://doi.org/10.1007/s00429-017-1408-0\">10.1007/s00429-017-1408-0</a>"},"date_updated":"2025-07-10T11:54:32Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"The neurotransmitter receptor subtype, number, density, and distribution relative to the location of transmitter release sites are key determinants of signal transmission. AMPA-type ionotropic glutamate receptors (AMPARs) containing GluA3 and GluA4 subunits are prominently expressed in subsets of neurons capable of firing action potentials at high frequencies, such as auditory relay neurons. The auditory nerve (AN) forms glutamatergic synapses on two types of relay neurons, bushy cells (BCs) and fusiform cells (FCs) of the cochlear nucleus. AN-BC and AN-FC synapses have distinct kinetics; thus, we investigated whether the number, density, and localization of GluA3 and GluA4 subunits in these synapses are differentially organized using quantitative freeze-fracture replica immunogold labeling. We identify a positive correlation between the number of AMPARs and the size of AN-BC and AN-FC synapses. Both types of AN synapses have similar numbers of AMPARs; however, the AN-BC have a higher density of AMPARs than AN-FC synapses, because the AN-BC synapses are smaller. A higher number and density of GluA3 subunits are observed at AN-BC synapses, whereas a higher number and density of GluA4 subunits are observed at AN-FC synapses. The intrasynaptic distribution of immunogold labeling revealed that AMPAR subunits, particularly GluA3, are concentrated at the center of the AN-BC synapses. The central distribution of AMPARs is absent in GluA3-knockout mice, and gold particles are evenly distributed along the postsynaptic density. GluA4 gold labeling was homogenously distributed along both synapse types. Thus, GluA3 and GluA4 subunits are distributed at AN synapses in a target-cell-dependent manner."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"type":"journal_article","volume":222,"date_published":"2017-11-01T00:00:00Z","publication_status":"published","department":[{"_id":"RySh"}],"pubrep_id":"881","isi":1,"date_created":"2018-12-11T11:48:14Z","intvolume":"       222","publist_id":"6932","publication_identifier":{"issn":["1863-2653"]},"author":[{"full_name":"Rubio, María","last_name":"Rubio","first_name":"María"},{"first_name":"Ko","last_name":"Matsui","full_name":"Matsui, Ko"},{"full_name":"Fukazawa, Yugo","last_name":"Fukazawa","first_name":"Yugo"},{"first_name":"Naomi","last_name":"Kamasawa","full_name":"Kamasawa, Naomi"},{"orcid":"0000-0001-7429-7896","full_name":"Harada, Harumi","id":"2E55CDF2-F248-11E8-B48F-1D18A9856A87","first_name":"Harumi","last_name":"Harada"},{"full_name":"Itakura, Makoto","last_name":"Itakura","first_name":"Makoto"},{"last_name":"Molnár","first_name":"Elek","full_name":"Molnár, Elek"},{"last_name":"Abe","first_name":"Manabu","full_name":"Abe, Manabu"},{"first_name":"Kenji","last_name":"Sakimura","full_name":"Sakimura, Kenji"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","last_name":"Shigemoto"}],"year":"2017","month":"11","status":"public","scopus_import":"1","quality_controlled":"1","title":"The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells","file":[{"relation":"main_file","file_name":"IST-2017-881-v1+1_s00429-017-1408-0.pdf","access_level":"open_access","date_created":"2018-12-12T10:10:20Z","date_updated":"2020-07-14T12:47:56Z","creator":"system","content_type":"application/pdf","file_id":"4806","file_size":4011126,"checksum":"73787a22507de8fb585bb598e1418ca7"}],"ddc":["571"],"oa_version":"Published Version","file_date_updated":"2020-07-14T12:47:56Z","doi":"10.1007/s00429-017-1408-0","external_id":{"isi":["000414761700002"]},"publication":"Brain Structure and Function","article_processing_charge":"No"},{"_id":"7360","article_type":"original","day":"01","publisher":"Elsevier","page":"102-119","type":"journal_article","volume":25,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"language":[{"iso":"eng"}],"abstract":[{"text":"Inflammation, which is a highly regulated host response against danger signals, may be harmful if it is excessive and deregulated. Ideally, anti-inflammatory therapy should autonomously commence as soon as possible after the onset of inflammation, should be controllable by a physician, and should not systemically block beneficial immune response in the long term. We describe a genetically encoded anti-inflammatory mammalian cell device based on a modular engineered genetic circuit comprising a sensor, an amplifier, a “thresholder” to restrict activation of a positive-feedback loop, a combination of advanced clinically used biopharmaceutical proteins, and orthogonal regulatory elements that linked modules into the functional device. This genetic circuit was autonomously activated by inflammatory signals, including endogenous cecal ligation and puncture (CLP)-induced inflammation in mice and serum from a systemic juvenile idiopathic arthritis (sIJA) patient, and could be reset externally by a chemical signal. The microencapsulated anti-inflammatory device significantly reduced the pathology in dextran sodium sulfate (DSS)-induced acute murine colitis, demonstrating a synthetic immunological approach for autonomous anti-inflammatory therapy.","lang":"eng"}],"date_updated":"2025-09-18T10:41:35Z","citation":{"mla":"Smole, Anže, et al. “A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation.” <i>Molecular Therapy</i>, vol. 25, no. 1, Elsevier, 2017, pp. 102–19, doi:<a href=\"https://doi.org/10.1016/j.ymthe.2016.10.005\">10.1016/j.ymthe.2016.10.005</a>.","short":"A. Smole, D. Lainšček, U. Bezeljak, S. Horvat, R. Jerala, Molecular Therapy 25 (2017) 102–119.","ama":"Smole A, Lainšček D, Bezeljak U, Horvat S, Jerala R. A synthetic mammalian therapeutic gene circuit for sensing and suppressing inflammation. <i>Molecular Therapy</i>. 2017;25(1):102-119. doi:<a href=\"https://doi.org/10.1016/j.ymthe.2016.10.005\">10.1016/j.ymthe.2016.10.005</a>","apa":"Smole, A., Lainšček, D., Bezeljak, U., Horvat, S., &#38; Jerala, R. (2017). A synthetic mammalian therapeutic gene circuit for sensing and suppressing inflammation. <i>Molecular Therapy</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ymthe.2016.10.005\">https://doi.org/10.1016/j.ymthe.2016.10.005</a>","chicago":"Smole, Anže, Duško Lainšček, Urban Bezeljak, Simon Horvat, and Roman Jerala. “A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation.” <i>Molecular Therapy</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.ymthe.2016.10.005\">https://doi.org/10.1016/j.ymthe.2016.10.005</a>.","ieee":"A. Smole, D. Lainšček, U. Bezeljak, S. Horvat, and R. Jerala, “A synthetic mammalian therapeutic gene circuit for sensing and suppressing inflammation,” <i>Molecular Therapy</i>, vol. 25, no. 1. Elsevier, pp. 102–119, 2017.","ista":"Smole A, Lainšček D, Bezeljak U, Horvat S, Jerala R. 2017. A synthetic mammalian therapeutic gene circuit for sensing and suppressing inflammation. Molecular Therapy. 25(1), 102–119."},"has_accepted_license":"1","tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"issue":"1","month":"01","status":"public","year":"2017","publication_identifier":{"issn":["1525-0016"]},"intvolume":"        25","author":[{"last_name":"Smole","first_name":"Anže","full_name":"Smole, Anže"},{"full_name":"Lainšček, Duško","last_name":"Lainšček","first_name":"Duško"},{"last_name":"Bezeljak","first_name":"Urban","full_name":"Bezeljak, Urban","id":"2A58201A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1365-5631"},{"full_name":"Horvat, Simon","first_name":"Simon","last_name":"Horvat"},{"first_name":"Roman","last_name":"Jerala","full_name":"Jerala, Roman"}],"isi":1,"date_created":"2020-01-25T15:55:39Z","department":[{"_id":"MaLo"}],"publication_status":"published","date_published":"2017-01-01T00:00:00Z","article_processing_charge":"No","pmid":1,"publication":"Molecular Therapy","ddc":["570"],"oa_version":"Published Version","file_date_updated":"2020-07-14T12:47:56Z","external_id":{"pmid":["28129106"],"isi":["000391901600013"]},"doi":"10.1016/j.ymthe.2016.10.005","file":[{"checksum":"ea8b1b28606dd1edab7379ba4fa3641f","file_size":3404806,"creator":"dernst","file_id":"7561","content_type":"application/pdf","date_updated":"2020-07-14T12:47:56Z","date_created":"2020-03-03T10:55:13Z","access_level":"open_access","file_name":"2017_MolecularTherapy_Smole.pdf","relation":"main_file"}],"quality_controlled":"1","title":"A synthetic mammalian therapeutic gene circuit for sensing and suppressing inflammation"},{"article_processing_charge":"No","publication":"Journal de Mathématiques Pures et Appliquées","doi":"10.1016/j.matpur.2017.05.013","oa_version":"Submitted Version","external_id":{"isi":["000414113600003"],"arxiv":["1604.05240"]},"scopus_import":"1","title":"A note on the validity of Bogoliubov correction to mean field dynamics","quality_controlled":"1","year":"2017","status":"public","month":"11","date_created":"2018-12-11T11:48:15Z","isi":1,"arxiv":1,"author":[{"first_name":"Phan","last_name":"Nam","id":"404092F4-F248-11E8-B48F-1D18A9856A87","full_name":"Nam, Phan"},{"last_name":"Napiórkowski","first_name":"Marcin M","full_name":"Napiórkowski, Marcin M","id":"4197AD04-F248-11E8-B48F-1D18A9856A87"}],"publication_identifier":{"issn":["0021-7824"]},"publist_id":"6928","intvolume":"       108","publication_status":"published","department":[{"_id":"RoSe"}],"corr_author":"1","date_published":"2017-11-01T00:00:00Z","main_file_link":[{"url":"https://arxiv.org/abs/1604.05240","open_access":"1"}],"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems","grant_number":"P27533_N27","_id":"25C878CE-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"volume":108,"type":"journal_article","date_updated":"2025-06-04T09:41:48Z","abstract":[{"lang":"eng","text":"We study the norm approximation to the Schrödinger dynamics of N bosons in with an interaction potential of the form . Assuming that in the initial state the particles outside of the condensate form a quasi-free state with finite kinetic energy, we show that in the large N limit, the fluctuations around the condensate can be effectively described using Bogoliubov approximation for all . The range of β is expected to be optimal for this large class of initial states."}],"language":[{"iso":"eng"}],"citation":{"mla":"Nam, Phan, and Marcin M. Napiórkowski. “A Note on the Validity of Bogoliubov Correction to Mean Field Dynamics.” <i>Journal de Mathématiques Pures et Appliquées</i>, vol. 108, no. 5, Elsevier, 2017, pp. 662–88, doi:<a href=\"https://doi.org/10.1016/j.matpur.2017.05.013\">10.1016/j.matpur.2017.05.013</a>.","ama":"Nam P, Napiórkowski MM. A note on the validity of Bogoliubov correction to mean field dynamics. <i>Journal de Mathématiques Pures et Appliquées</i>. 2017;108(5):662-688. doi:<a href=\"https://doi.org/10.1016/j.matpur.2017.05.013\">10.1016/j.matpur.2017.05.013</a>","short":"P. Nam, M.M. Napiórkowski, Journal de Mathématiques Pures et Appliquées 108 (2017) 662–688.","chicago":"Nam, Phan, and Marcin M Napiórkowski. “A Note on the Validity of Bogoliubov Correction to Mean Field Dynamics.” <i>Journal de Mathématiques Pures et Appliquées</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.matpur.2017.05.013\">https://doi.org/10.1016/j.matpur.2017.05.013</a>.","ieee":"P. Nam and M. M. Napiórkowski, “A note on the validity of Bogoliubov correction to mean field dynamics,” <i>Journal de Mathématiques Pures et Appliquées</i>, vol. 108, no. 5. Elsevier, pp. 662–688, 2017.","apa":"Nam, P., &#38; Napiórkowski, M. M. (2017). A note on the validity of Bogoliubov correction to mean field dynamics. <i>Journal de Mathématiques Pures et Appliquées</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.matpur.2017.05.013\">https://doi.org/10.1016/j.matpur.2017.05.013</a>","ista":"Nam P, Napiórkowski MM. 2017. A note on the validity of Bogoliubov correction to mean field dynamics. Journal de Mathématiques Pures et Appliquées. 108(5), 662–688."},"issue":"5","_id":"739","day":"01","publisher":"Elsevier","page":"662 - 688"},{"article_processing_charge":"No","pmid":1,"publication":"WIREs Developmental Biology","file":[{"relation":"main_file","checksum":"a9370f27b1591773b7a0de299bc81c8c","file_size":1647787,"content_type":"application/pdf","file_id":"7045","creator":"dernst","date_updated":"2020-07-14T12:47:57Z","date_created":"2019-11-19T07:36:18Z","access_level":"open_access","file_name":"2017_WIREs_Shigemoto.pdf"}],"ddc":["570"],"external_id":{"pmid":["28800674"],"isi":["000412827400005"]},"doi":"10.1002/wdev.288","file_date_updated":"2020-07-14T12:47:57Z","oa_version":"Submitted Version","scopus_import":"1","quality_controlled":"1","title":"The genetic encoded toolbox for electron microscopy and connectomics","year":"2017","month":"08","status":"public","isi":1,"date_created":"2018-12-11T11:48:15Z","publication_identifier":{"issn":["1759-7684"]},"publist_id":"6927","intvolume":"         6","author":[{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto"},{"first_name":"Maximilian A","last_name":"Jösch","orcid":"0000-0002-3937-1330","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","full_name":"Jösch, Maximilian A"}],"publication_status":"published","department":[{"_id":"RySh"},{"_id":"MaJö"}],"corr_author":"1","date_published":"2017-08-11T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"volume":6,"type":"journal_article","date_updated":"2025-07-10T11:54:34Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Developments in bioengineering and molecular biology have introduced a palette of genetically encoded probes for identification of specific cell populations in electron microscopy. These probes can be targeted to distinct cellular compartments, rendering them electron dense through a subsequent chemical reaction. These electron densities strongly increase the local contrast in samples prepared for electron microscopy, allowing three major advances in ultrastructural mapping of circuits: genetic identification of circuit components, targeted imaging of regions of interest and automated analysis of the tagged circuits. Together, the gains from these advances can decrease the time required for the analysis of targeted circuit motifs by over two orders of magnitude. These genetic encoded tags for electron microscopy promise to simplify the analysis of circuit motifs and become a central tool for structure‐function studies of synaptic connections in the brain. We review the current state‐of‐the‐art with an emphasis on connectomics, the quantitative analysis of neuronal structures and motifs."}],"citation":{"ista":"Shigemoto R, Jösch MA. 2017. The genetic encoded toolbox for electron microscopy and connectomics. WIREs Developmental Biology. 6(6), e288.","apa":"Shigemoto, R., &#38; Jösch, M. A. (2017). The genetic encoded toolbox for electron microscopy and connectomics. <i>WIREs Developmental Biology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/wdev.288\">https://doi.org/10.1002/wdev.288</a>","ieee":"R. Shigemoto and M. A. Jösch, “The genetic encoded toolbox for electron microscopy and connectomics,” <i>WIREs Developmental Biology</i>, vol. 6, no. 6. Wiley-Blackwell, 2017.","chicago":"Shigemoto, Ryuichi, and Maximilian A Jösch. “The Genetic Encoded Toolbox for Electron Microscopy and Connectomics.” <i>WIREs Developmental Biology</i>. Wiley-Blackwell, 2017. <a href=\"https://doi.org/10.1002/wdev.288\">https://doi.org/10.1002/wdev.288</a>.","short":"R. Shigemoto, M.A. Jösch, WIREs Developmental Biology 6 (2017).","ama":"Shigemoto R, Jösch MA. The genetic encoded toolbox for electron microscopy and connectomics. <i>WIREs Developmental Biology</i>. 2017;6(6). doi:<a href=\"https://doi.org/10.1002/wdev.288\">10.1002/wdev.288</a>","mla":"Shigemoto, Ryuichi, and Maximilian A. Jösch. “The Genetic Encoded Toolbox for Electron Microscopy and Connectomics.” <i>WIREs Developmental Biology</i>, vol. 6, no. 6, e288, Wiley-Blackwell, 2017, doi:<a href=\"https://doi.org/10.1002/wdev.288\">10.1002/wdev.288</a>."},"article_number":"e288","issue":"6","tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"license":"https://creativecommons.org/licenses/by-nc/4.0/","has_accepted_license":"1","_id":"740","article_type":"original","publisher":"Wiley-Blackwell","day":"11"},{"date_published":"2017-11-14T00:00:00Z","department":[{"_id":"ToHe"}],"publication_status":"published","page":"267 - 269","intvolume":"        51","publist_id":"6924","author":[{"full_name":"Gottlob, Georg","last_name":"Gottlob","first_name":"Georg"},{"last_name":"Henzinger","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","orcid":"0000−0002−2985−7724"},{"full_name":"Weißenbacher, Georg","first_name":"Georg","last_name":"Weißenbacher"}],"day":"14","publisher":"Springer","date_created":"2018-12-11T11:48:16Z","isi":1,"month":"11","_id":"743","status":"public","year":"2017","quality_controlled":"1","title":"Preface of the special issue in memoriam Helmut Veith","issue":"2","oa_version":"None","external_id":{"isi":["000415615600001"]},"doi":"10.1007/s10703-017-0307-6","citation":{"ista":"Gottlob G, Henzinger TA, Weißenbacher G. 2017. Preface of the special issue in memoriam Helmut Veith. Formal Methods in System Design. 51(2), 267–269.","apa":"Gottlob, G., Henzinger, T. A., &#38; Weißenbacher, G. (2017). Preface of the special issue in memoriam Helmut Veith. <i>Formal Methods in System Design</i>. Springer. <a href=\"https://doi.org/10.1007/s10703-017-0307-6\">https://doi.org/10.1007/s10703-017-0307-6</a>","chicago":"Gottlob, Georg, Thomas A Henzinger, and Georg Weißenbacher. “Preface of the Special Issue in Memoriam Helmut Veith.” <i>Formal Methods in System Design</i>. Springer, 2017. <a href=\"https://doi.org/10.1007/s10703-017-0307-6\">https://doi.org/10.1007/s10703-017-0307-6</a>.","ieee":"G. Gottlob, T. A. Henzinger, and G. Weißenbacher, “Preface of the special issue in memoriam Helmut Veith,” <i>Formal Methods in System Design</i>, vol. 51, no. 2. Springer, pp. 267–269, 2017.","short":"G. Gottlob, T.A. Henzinger, G. Weißenbacher, Formal Methods in System Design 51 (2017) 267–269.","ama":"Gottlob G, Henzinger TA, Weißenbacher G. Preface of the special issue in memoriam Helmut Veith. <i>Formal Methods in System Design</i>. 2017;51(2):267-269. doi:<a href=\"https://doi.org/10.1007/s10703-017-0307-6\">10.1007/s10703-017-0307-6</a>","mla":"Gottlob, Georg, et al. “Preface of the Special Issue in Memoriam Helmut Veith.” <i>Formal Methods in System Design</i>, vol. 51, no. 2, Springer, 2017, pp. 267–69, doi:<a href=\"https://doi.org/10.1007/s10703-017-0307-6\">10.1007/s10703-017-0307-6</a>."},"language":[{"iso":"eng"}],"abstract":[{"text":"This special issue of the Journal on Formal Methods in System Design is dedicated to Prof. Helmut Veith, who unexpectedly passed away in March 2016. Helmut Veith was a brilliant researcher, inspiring collaborator, passionate mentor, generous friend, and valued member of the formal methods community. Helmut was not only known for his numerous and influential contributions in the field of automated verification (most prominently his work on Counterexample-Guided Abstraction Refinement [1,2]), but also for his untiring and passionate efforts for the logic community: he co-organized the Vienna Summer of Logic (an event comprising twelve conferences and numerous workshops which attracted thousands of researchers from all over the world), he initiated the Vienna Center for Logic and Algorithms (which promotes international collaboration on logic and algorithms and organizes outreach events such as the LogicLounge), and he coordinated the Doctoral Program on Logical Methods in Computer Science at TU Wien (currently educating more than 40 doctoral students) and a National Research Network on Rigorous Systems Engineering (uniting fifteen researchers in Austria to address the challenge of building reliable and safe computer\r\nsystems). With his enthusiasm and commitment, Helmut completely reshaped the Austrian research landscape in the field of logic and verification in his few years as a full professor at TU Wien.","lang":"eng"}],"publication":"Formal Methods in System Design","date_updated":"2023-09-27T12:29:29Z","volume":51,"article_processing_charge":"No","type":"journal_article","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"article_type":"original","_id":"744","day":"21","publisher":"Elsevier","page":"64 - 72","volume":433,"type":"journal_article","project":[{"call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","name":"International IST Postdoc Fellowship Programme"},{"name":"Quantitative Graph Games: Theory and Applications","grant_number":"279307","_id":"2581B60A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"In evolutionary game theory interactions between individuals are often assumed obligatory. However, in many real-life situations, individuals can decide to opt out of an interaction depending on the information they have about the opponent. We consider a simple evolutionary game theoretic model to study such a scenario, where at each encounter between two individuals the type of the opponent (cooperator/defector) is known with some probability, and where each individual either accepts or opts out of the interaction. If the type of the opponent is unknown, a trustful individual accepts the interaction, whereas a suspicious individual opts out of the interaction. If either of the two individuals opt out both individuals remain without an interaction. We show that in the prisoners dilemma optional interactions along with suspicious behaviour facilitates the emergence of trustful cooperation."}],"date_updated":"2025-07-10T11:54:37Z","citation":{"ama":"Priklopil T, Chatterjee K, Nowak M. Optional interactions and suspicious behaviour facilitates trustful cooperation in prisoners dilemma. <i> Journal of Theoretical Biology</i>. 2017;433:64-72. doi:<a href=\"https://doi.org/10.1016/j.jtbi.2017.08.025\">10.1016/j.jtbi.2017.08.025</a>","short":"T. Priklopil, K. Chatterjee, M. Nowak,  Journal of Theoretical Biology 433 (2017) 64–72.","mla":"Priklopil, Tadeas, et al. “Optional Interactions and Suspicious Behaviour Facilitates Trustful Cooperation in Prisoners Dilemma.” <i> Journal of Theoretical Biology</i>, vol. 433, Elsevier, 2017, pp. 64–72, doi:<a href=\"https://doi.org/10.1016/j.jtbi.2017.08.025\">10.1016/j.jtbi.2017.08.025</a>.","ista":"Priklopil T, Chatterjee K, Nowak M. 2017. Optional interactions and suspicious behaviour facilitates trustful cooperation in prisoners dilemma.  Journal of Theoretical Biology. 433, 64–72.","chicago":"Priklopil, Tadeas, Krishnendu Chatterjee, and Martin Nowak. “Optional Interactions and Suspicious Behaviour Facilitates Trustful Cooperation in Prisoners Dilemma.” <i> Journal of Theoretical Biology</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.jtbi.2017.08.025\">https://doi.org/10.1016/j.jtbi.2017.08.025</a>.","ieee":"T. Priklopil, K. Chatterjee, and M. Nowak, “Optional interactions and suspicious behaviour facilitates trustful cooperation in prisoners dilemma,” <i> Journal of Theoretical Biology</i>, vol. 433. Elsevier, pp. 64–72, 2017.","apa":"Priklopil, T., Chatterjee, K., &#38; Nowak, M. (2017). Optional interactions and suspicious behaviour facilitates trustful cooperation in prisoners dilemma. <i> Journal of Theoretical Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jtbi.2017.08.025\">https://doi.org/10.1016/j.jtbi.2017.08.025</a>"},"tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"has_accepted_license":"1","month":"11","status":"public","year":"2017","intvolume":"       433","publication_identifier":{"issn":["0022-5193"]},"publist_id":"6923","author":[{"id":"3C869AA0-F248-11E8-B48F-1D18A9856A87","full_name":"Priklopil, Tadeas","first_name":"Tadeas","last_name":"Priklopil"},{"first_name":"Krishnendu","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Nowak, Martin","last_name":"Nowak","first_name":"Martin"}],"date_created":"2018-12-11T11:48:16Z","isi":1,"department":[{"_id":"KrCh"}],"publication_status":"published","date_published":"2017-11-21T00:00:00Z","ec_funded":1,"corr_author":"1","article_processing_charge":"No","publication":" Journal of Theoretical Biology","pmid":1,"ddc":["000","570"],"file_date_updated":"2020-07-14T12:47:58Z","doi":"10.1016/j.jtbi.2017.08.025","oa_version":"Submitted Version","external_id":{"isi":["000412039800007"],"pmid":["28867224"]},"file":[{"file_size":537323,"checksum":"4b43af1615ebf1a861840cb03d8a320c","file_id":"7047","content_type":"application/pdf","creator":"dernst","date_updated":"2020-07-14T12:47:58Z","date_created":"2019-11-19T07:57:39Z","file_name":"2017_JournTheoretBio_Priklopil.pdf","access_level":"open_access","relation":"main_file"}],"quality_controlled":"1","title":"Optional interactions and suspicious behaviour facilitates trustful cooperation in prisoners dilemma","scopus_import":"1"},{"project":[{"name":"Decoding the complexity of turbulence at its origin","grant_number":"306589","_id":"25152F3A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"type":"journal_article","volume":831,"date_updated":"2025-06-04T09:44:06Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Fluid flows in nature and applications are frequently subject to periodic velocity modulations. Surprisingly, even for the generic case of flow through a straight pipe, there is little consensus regarding the influence of pulsation on the transition threshold to turbulence: while most studies predict a monotonically increasing threshold with pulsation frequency (i.e. Womersley number, ), others observe a decreasing threshold for identical parameters and only observe an increasing threshold at low . In the present study we apply recent advances in the understanding of transition in steady shear flows to pulsating pipe flow. For moderate pulsation amplitudes we find that the first instability encountered is subcritical (i.e. requiring finite amplitude disturbances) and gives rise to localized patches of turbulence ('puffs') analogous to steady pipe flow. By monitoring the impact of pulsation on the lifetime of turbulence we map the onset of turbulence in parameter space. Transition in pulsatile flow can be separated into three regimes. At small Womersley numbers the dynamics is dominated by the decay turbulence suffers during the slower part of the cycle and hence transition is delayed significantly. As shown in this regime thresholds closely agree with estimates based on a quasi-steady flow assumption only taking puff decay rates into account. The transition point predicted in the zero limit equals to the critical point for steady pipe flow offset by the oscillation Reynolds number (i.e. the dimensionless oscillation amplitude). In the high frequency limit on the other hand, puff lifetimes are identical to those in steady pipe flow and hence the transition threshold appears to be unaffected by flow pulsation. In the intermediate frequency regime the transition threshold sharply drops (with increasing ) from the decay dominated (quasi-steady) threshold to the steady pipe flow level."}],"citation":{"ista":"Xu D, Warnecke S, Song B, Ma X, Hof B. 2017. Transition to turbulence in pulsating pipe flow. Journal of Fluid Mechanics. 831, 418–432.","chicago":"Xu, Duo, Sascha Warnecke, Baofang Song, Xingyu Ma, and Björn Hof. “Transition to Turbulence in Pulsating Pipe Flow.” <i>Journal of Fluid Mechanics</i>. Cambridge University Press, 2017. <a href=\"https://doi.org/10.1017/jfm.2017.620\">https://doi.org/10.1017/jfm.2017.620</a>.","ieee":"D. Xu, S. Warnecke, B. Song, X. Ma, and B. Hof, “Transition to turbulence in pulsating pipe flow,” <i>Journal of Fluid Mechanics</i>, vol. 831. Cambridge University Press, pp. 418–432, 2017.","apa":"Xu, D., Warnecke, S., Song, B., Ma, X., &#38; Hof, B. (2017). Transition to turbulence in pulsating pipe flow. <i>Journal of Fluid Mechanics</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/jfm.2017.620\">https://doi.org/10.1017/jfm.2017.620</a>","ama":"Xu D, Warnecke S, Song B, Ma X, Hof B. Transition to turbulence in pulsating pipe flow. <i>Journal of Fluid Mechanics</i>. 2017;831:418-432. doi:<a href=\"https://doi.org/10.1017/jfm.2017.620\">10.1017/jfm.2017.620</a>","short":"D. Xu, S. Warnecke, B. Song, X. Ma, B. Hof, Journal of Fluid Mechanics 831 (2017) 418–432.","mla":"Xu, Duo, et al. “Transition to Turbulence in Pulsating Pipe Flow.” <i>Journal of Fluid Mechanics</i>, vol. 831, Cambridge University Press, 2017, pp. 418–32, doi:<a href=\"https://doi.org/10.1017/jfm.2017.620\">10.1017/jfm.2017.620</a>."},"_id":"745","publisher":"Cambridge University Press","day":"25","page":"418 - 432","article_processing_charge":"No","publication":"Journal of Fluid Mechanics","doi":"10.1017/jfm.2017.620","external_id":{"arxiv":["1709.03738"],"isi":["000412934800005"]},"oa_version":"Submitted Version","scopus_import":"1","quality_controlled":"1","title":"Transition to turbulence in pulsating pipe flow","year":"2017","month":"11","status":"public","arxiv":1,"isi":1,"date_created":"2018-12-11T11:48:17Z","publication_identifier":{"issn":["0022-1120"]},"intvolume":"       831","publist_id":"6922","author":[{"full_name":"Xu, Duo","id":"3454D55E-F248-11E8-B48F-1D18A9856A87","first_name":"Duo","last_name":"Xu"},{"full_name":"Warnecke, Sascha","last_name":"Warnecke","first_name":"Sascha"},{"last_name":"Song","first_name":"Baofang","full_name":"Song, Baofang"},{"full_name":"Ma, Xingyu","id":"34BADBA6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0179-9737","last_name":"Ma","first_name":"Xingyu"},{"orcid":"0000-0003-2057-2754","id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","first_name":"Björn","last_name":"Hof"}],"publication_status":"published","department":[{"_id":"BjHo"}],"corr_author":"1","date_published":"2017-11-25T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1709.03738"}],"ec_funded":1},{"publisher":"Nature Publishing Group","day":"01","_id":"746","article_number":"1103","issue":"1","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","citation":{"short":"E. Aloisi, K. Le Corf, J. Dupuis, P. Zhang, M. Ginger, V. Labrousse, M. Spatuzza, M. Georg Haberl, L. Costa, R. Shigemoto, A. Tappe Theodor, F. Drago, P. Vincenzo Piazza, C. Mulle, L. Groc, L. Ciranna, M. Catania, A. Frick, Nature Communications 8 (2017).","ama":"Aloisi E, Le Corf K, Dupuis J, et al. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. <i>Nature Communications</i>. 2017;8(1). doi:<a href=\"https://doi.org/10.1038/s41467-017-01191-2\">10.1038/s41467-017-01191-2</a>","mla":"Aloisi, Elisabetta, et al. “Altered Surface MGluR5 Dynamics Provoke Synaptic NMDAR Dysfunction and Cognitive Defects in Fmr1 Knockout Mice.” <i>Nature Communications</i>, vol. 8, no. 1, 1103, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-01191-2\">10.1038/s41467-017-01191-2</a>.","ista":"Aloisi E, Le Corf K, Dupuis J, Zhang P, Ginger M, Labrousse V, Spatuzza M, Georg Haberl M, Costa L, Shigemoto R, Tappe Theodor A, Drago F, Vincenzo Piazza P, Mulle C, Groc L, Ciranna L, Catania M, Frick A. 2017. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nature Communications. 8(1), 1103.","apa":"Aloisi, E., Le Corf, K., Dupuis, J., Zhang, P., Ginger, M., Labrousse, V., … Frick, A. (2017). Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-017-01191-2\">https://doi.org/10.1038/s41467-017-01191-2</a>","ieee":"E. Aloisi <i>et al.</i>, “Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017.","chicago":"Aloisi, Elisabetta, Katy Le Corf, Julien Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, et al. “Altered Surface MGluR5 Dynamics Provoke Synaptic NMDAR Dysfunction and Cognitive Defects in Fmr1 Knockout Mice.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/s41467-017-01191-2\">https://doi.org/10.1038/s41467-017-01191-2</a>."},"date_updated":"2025-07-10T11:54:38Z","language":[{"iso":"eng"}],"abstract":[{"text":"Metabotropic glutamate receptor subtype 5 (mGluR5) is crucially implicated in the pathophysiology of Fragile X Syndrome (FXS); however, its dysfunction at the sub-cellular level, and related synaptic and cognitive phenotypes are unexplored. Here, we probed the consequences of mGluR5/Homer scaffold disruption for mGluR5 cell-surface mobility, synaptic N-methyl-D-Aspartate receptor (NMDAR) function, and behavioral phenotypes in the second-generation Fmr1 knockout (KO) mouse. Using single-molecule tracking, we found that mGluR5 was significantly more mobile at synapses in hippocampal Fmr1 KO neurons, causing an increased synaptic surface co-clustering of mGluR5 and NMDAR. This correlated with a reduced amplitude of synaptic NMDAR currents, a lack of their mGluR5-Activated long-Term depression, and NMDAR/hippocampus dependent cognitive deficits. These synaptic and behavioral phenomena were reversed by knocking down Homer1a in Fmr1 KO mice. Our study provides a mechanistic link between changes of mGluR5 dynamics and pathological phenotypes of FXS, unveiling novel targets for mGluR5-based therapeutics.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"type":"journal_article","volume":8,"date_published":"2017-12-01T00:00:00Z","publication_status":"published","department":[{"_id":"RySh"}],"pubrep_id":"915","date_created":"2018-12-11T11:48:17Z","isi":1,"publication_identifier":{"issn":["2041-1723"]},"intvolume":"         8","publist_id":"6921","author":[{"full_name":"Aloisi, Elisabetta","last_name":"Aloisi","first_name":"Elisabetta"},{"last_name":"Le Corf","first_name":"Katy","full_name":"Le Corf, Katy"},{"last_name":"Dupuis","first_name":"Julien","full_name":"Dupuis, Julien"},{"full_name":"Zhang, Pei","first_name":"Pei","last_name":"Zhang"},{"full_name":"Ginger, Melanie","last_name":"Ginger","first_name":"Melanie"},{"full_name":"Labrousse, Virginie","first_name":"Virginie","last_name":"Labrousse"},{"last_name":"Spatuzza","first_name":"Michela","full_name":"Spatuzza, Michela"},{"full_name":"Georg Haberl, Matthias","first_name":"Matthias","last_name":"Georg Haberl"},{"full_name":"Costa, Lara","last_name":"Costa","first_name":"Lara"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Tappe Theodor, Anke","first_name":"Anke","last_name":"Tappe Theodor"},{"full_name":"Drago, Fillippo","first_name":"Fillippo","last_name":"Drago"},{"last_name":"Vincenzo Piazza","first_name":"Pier","full_name":"Vincenzo Piazza, Pier"},{"full_name":"Mulle, Christophe","last_name":"Mulle","first_name":"Christophe"},{"first_name":"Laurent","last_name":"Groc","full_name":"Groc, Laurent"},{"first_name":"Lucia","last_name":"Ciranna","full_name":"Ciranna, Lucia"},{"last_name":"Catania","first_name":"Maria","full_name":"Catania, Maria"},{"first_name":"Andreas","last_name":"Frick","full_name":"Frick, Andreas"}],"year":"2017","month":"12","status":"public","scopus_import":"1","quality_controlled":"1","title":"Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice","file":[{"file_name":"IST-2017-915-v1+1_s41467-017-01191-2.pdf","access_level":"open_access","date_updated":"2020-07-14T12:47:58Z","date_created":"2018-12-12T10:17:32Z","file_id":"5287","content_type":"application/pdf","creator":"system","file_size":1841650,"checksum":"99ceee57549dc0461e3adfc037ec70a9","relation":"main_file"}],"ddc":["571"],"external_id":{"isi":["000413571300004"]},"file_date_updated":"2020-07-14T12:47:58Z","oa_version":"Published Version","doi":"10.1038/s41467-017-01191-2","publication":"Nature Communications","article_processing_charge":"No"},{"doi":"10.3726/b11899","citation":{"ista":"Wenzl B. 2017.‘...beyond the invisible barrier at Portage and Main’: Liminality in John Marlyn’s Under the Ribs of Death. In: In-Between - Liminal Spaces in Canadian Literature and Culture. Canadiana, , 91–100.","chicago":"Wenzl, Bernhard. “‘...Beyond the Invisible Barrier at Portage and Main’: Liminality in John Marlyn’s Under the Ribs of Death.” In <i>In-Between - Liminal Spaces in Canadian Literature and Culture</i>, edited by Stefan Brandt, 91–100. Peter Lang GmbH, 2017. <a href=\"https://doi.org/10.3726/b11899\">https://doi.org/10.3726/b11899</a>.","ieee":"B. Wenzl, “‘...beyond the invisible barrier at Portage and Main’: Liminality in John Marlyn’s Under the Ribs of Death,” in <i>In-Between - Liminal Spaces in Canadian Literature and Culture</i>, S. Brandt, Ed. Peter Lang GmbH, 2017, pp. 91–100.","apa":"Wenzl, B. (2017). “...beyond the invisible barrier at Portage and Main”: Liminality in John Marlyn’s Under the Ribs of Death. In S. Brandt (Ed.), <i>In-Between - Liminal Spaces in Canadian Literature and Culture</i> (pp. 91–100). Peter Lang GmbH. <a href=\"https://doi.org/10.3726/b11899\">https://doi.org/10.3726/b11899</a>","ama":"Wenzl B. “...beyond the invisible barrier at Portage and Main”: Liminality in John Marlyn’s Under the Ribs of Death. In: Brandt S, ed. <i>In-Between - Liminal Spaces in Canadian Literature and Culture</i>. Peter Lang GmbH; 2017:91-100. doi:<a href=\"https://doi.org/10.3726/b11899\">10.3726/b11899</a>","short":"B. Wenzl, in:, S. Brandt (Ed.), In-Between - Liminal Spaces in Canadian Literature and Culture, Peter Lang GmbH, 2017, pp. 91–100.","mla":"Wenzl, Bernhard. “‘...Beyond the Invisible Barrier at Portage and Main’: Liminality in John Marlyn’s Under the Ribs of Death.” <i>In-Between - Liminal Spaces in Canadian Literature and Culture</i>, edited by Stefan Brandt, Peter Lang GmbH, 2017, pp. 91–100, doi:<a href=\"https://doi.org/10.3726/b11899\">10.3726/b11899</a>."},"oa_version":"None","alternative_title":["Canadiana"],"title":"'...beyond the invisible barrier at Portage and Main': Liminality in John Marlyn's Under the Ribs of Death","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","type":"book_chapter","date_updated":"2025-09-04T06:53:20Z","language":[{"iso":"eng"}],"publication":"In-Between - Liminal Spaces in Canadian Literature and Culture","abstract":[{"lang":"eng","text":"The essay focuses on individual and collective forms of liminality in John Marlyn’s Under the Ribs of Death. Set in early twentieth-century Winnipeg, the 1957 immigrant novel explores liminal experiences related to ethnic identity, male sexuality, social class, urban spaces and turbulent economic times. As the son of a poor working-class family from Hungary, Sandor Hunyadi makes every effort to become a true Canadian and a successful businessman, but, no matter how hard he tries to overcome contemporary ethnic prejudices and economic hardships, his personal and professional life remains in liminality. In other words, the protagonist undergoes separation, fails at incorporation, and becomes stuck in transition."}],"publication_status":"published","page":"91 - 100","editor":[{"first_name":"Stefan","last_name":"Brandt","full_name":"Brandt, Stefan"}],"date_published":"2017-12-01T00:00:00Z","year":"2017","_id":"748","month":"12","status":"public","publisher":"Peter Lang GmbH","day":"01","date_created":"2018-12-11T11:48:18Z","publication_identifier":{"isbn":[" 9783631735695"]},"publist_id":"6909","extern":"1","author":[{"id":"479E9046-F248-11E8-B48F-1D18A9856A87","full_name":"Wenzl, Bernhard","last_name":"Wenzl","first_name":"Bernhard"}]},{"page":"3760 - 3763","publication_status":"published","department":[{"_id":"ChLa"}],"date_published":"2017-12-01T00:00:00Z","year":"2017","status":"public","month":"12","_id":"750","date_created":"2018-12-11T11:48:18Z","day":"01","publisher":"IEEE","author":[{"first_name":"Jasmin","last_name":"Pielorz","full_name":"Pielorz, Jasmin","id":"49BC895A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Prandtstetter, Matthias","first_name":"Matthias","last_name":"Prandtstetter"},{"first_name":"Markus","last_name":"Straub","full_name":"Straub, Markus"},{"last_name":"Lampert","first_name":"Christoph","full_name":"Lampert, Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8622-7887"}],"publist_id":"6906","publication_identifier":{"isbn":["978-153862714-3"]},"citation":{"mla":"Pielorz, Jasmin, et al. “Optimal Geospatial Volunteer Allocation Needs Realistic Distances.” <i>2017 IEEE International Conference on Big Data</i>, IEEE, 2017, pp. 3760–63, doi:<a href=\"https://doi.org/10.1109/BigData.2017.8258375\">10.1109/BigData.2017.8258375</a>.","ama":"Pielorz J, Prandtstetter M, Straub M, Lampert C. Optimal geospatial volunteer allocation needs realistic distances. In: <i>2017 IEEE International Conference on Big Data</i>. IEEE; 2017:3760-3763. doi:<a href=\"https://doi.org/10.1109/BigData.2017.8258375\">10.1109/BigData.2017.8258375</a>","short":"J. Pielorz, M. Prandtstetter, M. Straub, C. Lampert, in:, 2017 IEEE International Conference on Big Data, IEEE, 2017, pp. 3760–3763.","ieee":"J. Pielorz, M. Prandtstetter, M. Straub, and C. Lampert, “Optimal geospatial volunteer allocation needs realistic distances,” in <i>2017 IEEE International Conference on Big Data</i>, Boston, MA, United States, 2017, pp. 3760–3763.","chicago":"Pielorz, Jasmin, Matthias Prandtstetter, Markus Straub, and Christoph Lampert. “Optimal Geospatial Volunteer Allocation Needs Realistic Distances.” In <i>2017 IEEE International Conference on Big Data</i>, 3760–63. IEEE, 2017. <a href=\"https://doi.org/10.1109/BigData.2017.8258375\">https://doi.org/10.1109/BigData.2017.8258375</a>.","apa":"Pielorz, J., Prandtstetter, M., Straub, M., &#38; Lampert, C. (2017). Optimal geospatial volunteer allocation needs realistic distances. In <i>2017 IEEE International Conference on Big Data</i> (pp. 3760–3763). Boston, MA, United States: IEEE. <a href=\"https://doi.org/10.1109/BigData.2017.8258375\">https://doi.org/10.1109/BigData.2017.8258375</a>","ista":"Pielorz J, Prandtstetter M, Straub M, Lampert C. 2017. Optimal geospatial volunteer allocation needs realistic distances. 2017 IEEE International Conference on Big Data. Big Data, 3760–3763."},"doi":"10.1109/BigData.2017.8258375","oa_version":"None","scopus_import":1,"conference":{"end_date":"2017-12-14","name":"Big Data","location":"Boston, MA, United States","start_date":"2017-12-11"},"title":"Optimal geospatial volunteer allocation needs realistic distances","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","date_updated":"2021-01-12T08:13:55Z","abstract":[{"lang":"eng","text":"Modern communication technologies allow first responders to contact thousands of potential volunteers simultaneously for support during a crisis or disaster event. However, such volunteer efforts must be well coordinated and monitored, in order to offer an effective relief to the professionals. In this paper we extend earlier work on optimally assigning volunteers to selected landmark locations. In particular, we emphasize the aspect that obtaining good assignments requires not only advanced computational tools, but also a realistic measure of distance between volunteers and landmarks. Specifically, we propose the use of the Open Street Map (OSM) driving distance instead of he previously used flight distance. We find the OSM driving distance to be better aligned with the interests of volunteers and first responders. Furthermore, we show that relying on the flying distance leads to a substantial underestimation of the number of required volunteers, causing negative side effects in case of an actual crisis situation."}],"publication":"2017 IEEE International Conference on Big Data","language":[{"iso":"eng"}]},{"date_published":"2017-11-09T00:00:00Z","publication_status":"published","department":[{"_id":"DaSi"}],"pubrep_id":"875","date_created":"2018-12-11T11:48:18Z","isi":1,"publist_id":"6905","intvolume":"        27","publication_identifier":{"issn":["09609822"]},"author":[{"last_name":"Matsubayashi","first_name":"Yutaka","full_name":"Matsubayashi, Yutaka"},{"full_name":"Louani, Adam","last_name":"Louani","first_name":"Adam"},{"full_name":"Dragu, Anca","first_name":"Anca","last_name":"Dragu"},{"first_name":"Besaiz","last_name":"Sanchez Sanchez","full_name":"Sanchez Sanchez, Besaiz"},{"last_name":"Serna Morales","first_name":"Eduardo","full_name":"Serna Morales, Eduardo"},{"last_name":"Yolland","first_name":"Lawrence","full_name":"Yolland, Lawrence"},{"id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87","full_name":"György, Attila","orcid":"0000-0002-1819-198X","last_name":"György","first_name":"Attila"},{"first_name":"Gema","last_name":"Vizcay","full_name":"Vizcay, Gema"},{"full_name":"Fleck, Roland","first_name":"Roland","last_name":"Fleck"},{"full_name":"Heddleston, John","last_name":"Heddleston","first_name":"John"},{"first_name":"Teng","last_name":"Chew","full_name":"Chew, Teng"},{"orcid":"0000-0001-8323-8353","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","full_name":"Siekhaus, Daria E","first_name":"Daria E","last_name":"Siekhaus"},{"first_name":"Brian","last_name":"Stramer","full_name":"Stramer, Brian"}],"year":"2017","month":"11","status":"public","scopus_import":"1","quality_controlled":"1","title":"A moving source of matrix components is essential for De Novo basement membrane formation","file":[{"file_size":4770657,"checksum":"264cf6c6c3551486ba5ea786850e000a","file_id":"4770","content_type":"application/pdf","creator":"system","date_created":"2018-12-12T10:09:45Z","date_updated":"2020-07-14T12:47:59Z","file_name":"IST-2017-875-v1+1_1-s2.0-S0960982217312691-main.pdf","access_level":"open_access","relation":"main_file"}],"ddc":["570","576"],"doi":"10.1016/j.cub.2017.10.001","file_date_updated":"2020-07-14T12:47:59Z","oa_version":"Published Version","external_id":{"isi":["000415815800031"]},"publication":"Current Biology","article_processing_charge":"No","page":"3526 - 3534e.4","day":"09","publisher":"Cell Press","_id":"751","issue":"22","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","citation":{"apa":"Matsubayashi, Y., Louani, A., Dragu, A., Sanchez Sanchez, B., Serna Morales, E., Yolland, L., … Stramer, B. (2017). A moving source of matrix components is essential for De Novo basement membrane formation. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2017.10.001\">https://doi.org/10.1016/j.cub.2017.10.001</a>","chicago":"Matsubayashi, Yutaka, Adam Louani, Anca Dragu, Besaiz Sanchez Sanchez, Eduardo Serna Morales, Lawrence Yolland, Attila György, et al. “A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation.” <i>Current Biology</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.cub.2017.10.001\">https://doi.org/10.1016/j.cub.2017.10.001</a>.","ieee":"Y. Matsubayashi <i>et al.</i>, “A moving source of matrix components is essential for De Novo basement membrane formation,” <i>Current Biology</i>, vol. 27, no. 22. Cell Press, p. 3526–3534e.4, 2017.","ista":"Matsubayashi Y, Louani A, Dragu A, Sanchez Sanchez B, Serna Morales E, Yolland L, György A, Vizcay G, Fleck R, Heddleston J, Chew T, Siekhaus DE, Stramer B. 2017. A moving source of matrix components is essential for De Novo basement membrane formation. Current Biology. 27(22), 3526–3534e.4.","mla":"Matsubayashi, Yutaka, et al. “A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation.” <i>Current Biology</i>, vol. 27, no. 22, Cell Press, 2017, p. 3526–3534e.4, doi:<a href=\"https://doi.org/10.1016/j.cub.2017.10.001\">10.1016/j.cub.2017.10.001</a>.","short":"Y. Matsubayashi, A. Louani, A. Dragu, B. Sanchez Sanchez, E. Serna Morales, L. Yolland, A. György, G. Vizcay, R. Fleck, J. Heddleston, T. Chew, D.E. Siekhaus, B. Stramer, Current Biology 27 (2017) 3526–3534e.4.","ama":"Matsubayashi Y, Louani A, Dragu A, et al. A moving source of matrix components is essential for De Novo basement membrane formation. <i>Current Biology</i>. 2017;27(22):3526-3534e.4. doi:<a href=\"https://doi.org/10.1016/j.cub.2017.10.001\">10.1016/j.cub.2017.10.001</a>"},"date_updated":"2023-09-27T12:25:31Z","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"The basement membrane (BM) is a thin layer of extracellular matrix (ECM) beneath nearly all epithelial cell types that is critical for cellular and tissue function. It is composed of numerous components conserved among all bilaterians [1]; however, it is unknown how all of these components are generated and subsequently constructed to form a fully mature BM in the living animal. Although BM formation is thought to simply involve a process of self-assembly [2], this concept suffers from a number of logistical issues when considering its construction in vivo. First, incorporation of BM components appears to be hierarchical [3-5], yet it is unclear whether their production during embryogenesis must also be regulated in a temporal fashion. Second, many BM proteins are produced not only by the cells residing on the BM but also by surrounding cell types [6-9], and it is unclear how large, possibly insoluble protein complexes [10] are delivered into the matrix. Here we exploit our ability to live image and genetically dissect de novo BM formation during Drosophila development. This reveals that there is a temporal hierarchy of BM protein production that is essential for proper component incorporation. Furthermore, we show that BM components require secretion by migrating macrophages (hemocytes) during their developmental dispersal, which is critical for embryogenesis. Indeed, hemocyte migration is essential to deliver a subset of ECM components evenly throughout the embryo. This reveals that de novo BM construction requires a combination of both production and distribution logistics allowing for the timely delivery of core components."}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1,"volume":27,"type":"journal_article"},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.17632/nw68fxzjpm.1"}],"date_published":"2017-12-29T00:00:00Z","department":[{"_id":"NiBa"}],"date_created":"2021-08-09T13:18:55Z","publisher":"Mendeley Data","day":"29","author":[{"first_name":"Alison","last_name":"Etheridge","full_name":"Etheridge, Alison"},{"last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240"}],"related_material":{"record":[{"id":"564","status":"public","relation":"used_in_publication"}]},"year":"2017","status":"public","_id":"9842","month":"12","title":"Data for: Establishment in a new habitat by polygenic adaptation","citation":{"mla":"Etheridge, Alison, and Nicholas H. Barton. <i>Data for: Establishment in a New Habitat by Polygenic Adaptation</i>. Mendeley Data, 2017, doi:<a href=\"https://doi.org/10.17632/nw68fxzjpm.1\">10.17632/nw68fxzjpm.1</a>.","ama":"Etheridge A, Barton NH. Data for: Establishment in a new habitat by polygenic adaptation. 2017. doi:<a href=\"https://doi.org/10.17632/nw68fxzjpm.1\">10.17632/nw68fxzjpm.1</a>","short":"A. Etheridge, N.H. Barton, (2017).","ieee":"A. Etheridge and N. H. Barton, “Data for: Establishment in a new habitat by polygenic adaptation.” Mendeley Data, 2017.","chicago":"Etheridge, Alison, and Nicholas H Barton. “Data for: Establishment in a New Habitat by Polygenic Adaptation.” Mendeley Data, 2017. <a href=\"https://doi.org/10.17632/nw68fxzjpm.1\">https://doi.org/10.17632/nw68fxzjpm.1</a>.","apa":"Etheridge, A., &#38; Barton, N. H. (2017). Data for: Establishment in a new habitat by polygenic adaptation. 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