[{"publication_identifier":{"issn":["1930-5346"]},"volume":12,"publisher":"AIMS","language":[{"iso":"eng"}],"page":"17-47","citation":{"ama":"Chatterjee S, Kamath Hosdurg C, Kumar V. Private set-intersection with common set-up. <i>Advances in Mathematics of Communications</i>. 2018;12(1):17-47. doi:<a href=\"https://doi.org/10.3934/amc.2018002\">10.3934/amc.2018002</a>","ieee":"S. Chatterjee, C. Kamath Hosdurg, and V. Kumar, “Private set-intersection with common set-up,” <i>Advances in Mathematics of Communications</i>, vol. 12, no. 1. AIMS, pp. 17–47, 2018.","short":"S. Chatterjee, C. Kamath Hosdurg, V. Kumar, Advances in Mathematics of Communications 12 (2018) 17–47.","ista":"Chatterjee S, Kamath Hosdurg C, Kumar V. 2018. Private set-intersection with common set-up. Advances in Mathematics of Communications. 12(1), 17–47.","mla":"Chatterjee, Sanjit, et al. “Private Set-Intersection with Common Set-Up.” <i>Advances in Mathematics of Communications</i>, vol. 12, no. 1, AIMS, 2018, pp. 17–47, doi:<a href=\"https://doi.org/10.3934/amc.2018002\">10.3934/amc.2018002</a>.","apa":"Chatterjee, S., Kamath Hosdurg, C., &#38; Kumar, V. (2018). Private set-intersection with common set-up. <i>Advances in Mathematics of Communications</i>. AIMS. <a href=\"https://doi.org/10.3934/amc.2018002\">https://doi.org/10.3934/amc.2018002</a>","chicago":"Chatterjee, Sanjit, Chethan Kamath Hosdurg, and Vikas Kumar. “Private Set-Intersection with Common Set-Up.” <i>Advances in Mathematics of Communications</i>. AIMS, 2018. <a href=\"https://doi.org/10.3934/amc.2018002\">https://doi.org/10.3934/amc.2018002</a>."},"author":[{"last_name":"Chatterjee","full_name":"Chatterjee, Sanjit","first_name":"Sanjit"},{"full_name":"Kamath Hosdurg, Chethan","orcid":"0009-0006-6812-7317","id":"4BD3F30E-F248-11E8-B48F-1D18A9856A87","first_name":"Chethan","last_name":"Kamath Hosdurg"},{"first_name":"Vikas","full_name":"Kumar, Vikas","last_name":"Kumar"}],"issue":"1","type":"journal_article","fulldoi":"https://doi.org/10.3934/amc.2018002","doi":"10.3934/amc.2018002","article_processing_charge":"No","scopus_import":"1","year":"2018","date_created":"2019-02-13T13:49:41Z","publication_status":"published","intvolume":"        12","date_updated":"2026-08-12T09:13:26Z","quality_controlled":"1","publication":"Advances in Mathematics of Communications","date_published":"2018-02-01T00:00:00Z","department":[{"_id":"KrPi"}],"_id":"5980","abstract":[{"text":"The problem of private set-intersection (PSI) has been traditionally treated as an instance of the more general problem of multi-party computation (MPC). Consequently, in order to argue security, or compose these protocols one has to rely on the general theory that was developed for the purpose of MPC. The pursuit of efficient protocols, however, has resulted in designs that exploit properties pertaining to PSI. In almost all practical applications where a PSI protocol is deployed, it is expected to be executed multiple times, possibly on related inputs. In this work we initiate a dedicated study of PSI in the multi-interaction (MI) setting. In this model a server sets up the common system parameters and executes set-intersection multiple times with potentially different clients. We discuss a few attacks that arise when protocols are naïvely composed in this manner and, accordingly, craft security definitions for the MI setting and study their inter-relation. Finally, we suggest a set of protocols that are MI-secure, at the same time almost as efficient as their parent, stand-alone, protocols.","lang":"eng"}],"oa_version":"None","external_id":{"isi":["000430950400002"]},"title":"Private set-intersection with common set-up","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"01","month":"02","status":"public","isi":1},{"degree_awarded":"PhD","OA_place":"publisher","has_accepted_license":"1","title":"Optical and optogenetic control of proliferation and survival ","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","corr_author":"1","month":"01","related_material":{"record":[{"relation":"part_of_dissertation","id":"1678","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"2084"},{"status":"public","id":"1441","relation":"part_of_dissertation"},{"status":"public","id":"1028","relation":"part_of_dissertation"}]},"day":"08","status":"public","abstract":[{"text":"The aim of this thesis was the development of new strategies for optical and optogenetic control of proliferative and pro-survival signaling, and characterizing them from the molecular mechanism up to cellular effects. These new light-based methods have unique features, such as red light as an activator, or the avoidance of gene delivery, which enable to overcome current limitations, such as light delivery to target tissues and feasibility as therapeutic approach. A special focus was placed on implementing these new light-based approaches in pancreatic β-cells, as β-cells are the key players in diabetes and especially their loss in number negatively affects disease progression. Currently no treatment options are available to compensate the lack of functional β-cells in diabetic patients.\r\nIn a first approach, red-light-activated growth factor receptors, in particular receptor tyrosine kinases were engineered and characterized. Receptor activation with light allows spatio-temporal control compared to ligand-based activation, and especially red light exhibits deeper tissue penetration than other wavelengths of the visible spectrum. Red-light-activated receptor tyrosine kinases robustly activated major growth factor related signaling pathways with a high temporal resolution. Moreover, the remote activation of the proliferative MAPK/Erk pathway by red-light-activated receptor tyrosine kinases in a pancreatic β-cell line was also achieved, through one centimeter thick mouse tissue. Although red-light-activated receptor tyrosine kinases are particularly attractive for applications in animal models due to the deep tissue penetration of red light, a drawback, especially with regard to translation into humans, is the requirement of gene therapy.\r\nIn a second approach an endogenous light-sensitive mechanism was identified and its potential to promote proliferative and pro-survival signals was explored, towards light-based tissue regeneration without the need for gene transfer. Blue-green light illumination was found to be sufficient for the activation of proliferation and survival promoting signaling pathways in primary pancreatic murine and human islets. Blue-green light also led to an increase in proliferation of primary islet cells, an effect which was shown to be mostly β-cell specific in human islets. Moreover, it was demonstrated that this approach of pancreatic β-cell expansion did not have any negative effect on the β-cell function, in particular on their insulin secretion capacity. In contrast, a trend for enhanced insulin secretion under high glucose conditions after illumination was detected. In order to unravel the detailed characteristics of this endogenous light-sensitive mechanism, the precise light requirements were determined. In addition, the expression of light sensing proteins, OPN3 and rhodopsin, was detected. The observed effects were found to be independent of handling effects such as temperature differences and cytochrome c oxidase dependent ATP increase, but they were found to be enhanced through the knockout of OPN3. The exact mechanism of how islets cells sense light and the identity of the photoreceptor remains unknown.\r\nSummarized two new light-based systems with unique features were established that enable the activation of proliferative and pro-survival signaling pathways. While red-light-activated receptor tyrosine kinases open a new avenue for optogenetics research, by allowing non-invasive control of signaling in vivo, the identified endogenous light-sensitive mechanism has the potential to be the basis of a gene therapy-free therapeutical approach for light-based β-cell expansion.","lang":"eng"}],"_id":"418","oa_version":"Published Version","department":[{"_id":"HaJa"}],"alternative_title":["ISTA Thesis"],"date_updated":"2026-08-12T09:19:21Z","publist_id":"7405","date_published":"2018-01-08T00:00:00Z","article_processing_charge":"No","supervisor":[{"first_name":"Harald L","full_name":"Janovjak, Harald L","orcid":"0000-0002-8023-9315","id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","last_name":"Janovjak"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:th_913","doi":"10.15479/AT:ISTA:th_913","publication_status":"published","date_created":"2018-12-11T11:46:22Z","year":"2018","type":"dissertation","author":[{"first_name":"Eva","id":"3FEE232A-F248-11E8-B48F-1D18A9856A87","full_name":"Gschaider-Reichhart, Eva","orcid":"0000-0002-7218-7738","last_name":"Gschaider-Reichhart"}],"file_date_updated":"2020-07-14T12:46:24Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"citation":{"apa":"Gschaider-Reichhart, E. (2018). <i>Optical and optogenetic control of proliferation and survival </i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_913\">https://doi.org/10.15479/AT:ISTA:th_913</a>","mla":"Gschaider-Reichhart, Eva. <i>Optical and Optogenetic Control of Proliferation and Survival </i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_913\">10.15479/AT:ISTA:th_913</a>.","ista":"Gschaider-Reichhart E. 2018. Optical and optogenetic control of proliferation and survival . Institute of Science and Technology Austria.","chicago":"Gschaider-Reichhart, Eva. “Optical and Optogenetic Control of Proliferation and Survival .” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_913\">https://doi.org/10.15479/AT:ISTA:th_913</a>.","ieee":"E. Gschaider-Reichhart, “Optical and optogenetic control of proliferation and survival ,” Institute of Science and Technology Austria, 2018.","ama":"Gschaider-Reichhart E. Optical and optogenetic control of proliferation and survival . 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_913\">10.15479/AT:ISTA:th_913</a>","short":"E. Gschaider-Reichhart, Optical and Optogenetic Control of Proliferation and Survival , Institute of Science and Technology Austria, 2018."},"ddc":["571","570"],"pubrep_id":"913","publisher":"Institute of Science and Technology Austria","page":"107","language":[{"iso":"eng"}],"oa":1,"publication_identifier":{"issn":["2663-337X"]},"file":[{"file_id":"6222","creator":"dernst","date_updated":"2020-07-14T12:46:24Z","file_name":"2018_THESIS_Gschaider-Reichhart_source.docx","file_size":7012495,"access_level":"closed","date_created":"2019-04-05T09:28:03Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","relation":"source_file","checksum":"697fa72ca36fb1b8ceabc133d58a73e5"},{"file_id":"6223","creator":"dernst","file_size":6355280,"date_updated":"2020-07-14T12:46:24Z","file_name":"2018_THESIS_Gschaider-Reichhart.pdf","content_type":"application/pdf","date_created":"2019-04-05T09:28:03Z","access_level":"open_access","checksum":"58d7d1e9e58aeb7f061ab686b1d8a48c","relation":"main_file"}]},{"project":[{"call_identifier":"FP7","name":"Random matrices, universality and disordered quantum systems","grant_number":"338804","_id":"258DCDE6-B435-11E9-9278-68D0E5697425"}],"department":[{"_id":"LaEr"}],"oa_version":"Published Version","_id":"149","ec_funded":1,"abstract":[{"lang":"eng","text":"The eigenvalue density of many large random matrices is well approximated by a deterministic measure, the self-consistent density of states. In the present work, we show this behaviour for several classes of random matrices. In fact, we establish that, in each of these classes, the self-consistent density of states approximates the eigenvalue density of the random matrix on all scales slightly above the typical eigenvalue spacing. For large classes of random matrices, the self-consistent density of states exhibits several universal features. We prove that, under suitable assumptions, random Gram matrices and Hermitian random matrices with decaying correlations have a 1/3-Hölder continuous self-consistent density of states ρ on R, which is analytic, where it is positive, and has either a square root edge or a cubic root cusp, where it vanishes. We, thus, extend the validity of the corresponding result for Wigner-type matrices from [4, 5, 7]. We show that ρ is determined as the inverse Stieltjes transform of the normalized trace of the unique solution m(z) to the Dyson equation −m(z) −1 = z − a + S[m(z)] on C N×N with the constraint Im m(z) ≥ 0. Here, z lies in the complex upper half-plane, a is a self-adjoint element of C N×N and S is a positivity-preserving operator on C N×N encoding the first two moments of the random matrix. In order to analyze a possible limit of ρ for N → ∞ and address some applications in free probability theory, we also consider the Dyson equation on infinite dimensional von Neumann algebras. We present two applications to random matrices. We first establish that, under certain assumptions, large random matrices with independent entries have a rotationally symmetric self-consistent density of states which is supported on a centered disk in C. Moreover, it is infinitely often differentiable apart from a jump on the boundary of this disk. Second, we show edge universality at all regular (not necessarily extreme) spectral edges for Hermitian random matrices with decaying correlations."}],"alternative_title":["ISTA Thesis"],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Dyson equation and eigenvalue statistics of random matrices","degree_awarded":"PhD","has_accepted_license":"1","OA_place":"publisher","status":"public","related_material":{"record":[{"id":"6184","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"6183","relation":"part_of_dissertation"},{"status":"public","id":"1010","relation":"part_of_dissertation"},{"id":"550","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","id":"6240","status":"public"},{"status":"public","id":"566","relation":"part_of_dissertation"},{"id":"1677","relation":"part_of_dissertation","status":"public"}]},"day":"12","month":"07","corr_author":"1","doi":"10.15479/AT:ISTA:TH_1040","fulldoi":"https://doi.org/10.15479/AT:ISTA:TH_1040","article_processing_charge":"No","supervisor":[{"first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös"}],"year":"2018","date_created":"2018-12-11T11:44:53Z","publication_status":"published","publist_id":"7772","date_updated":"2026-08-12T13:58:56Z","date_published":"2018-07-12T00:00:00Z","citation":{"apa":"Alt, J. (2018). <i>Dyson equation and eigenvalue statistics of random matrices</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1040\">https://doi.org/10.15479/AT:ISTA:TH_1040</a>","ista":"Alt J. 2018. Dyson equation and eigenvalue statistics of random matrices. Institute of Science and Technology Austria.","mla":"Alt, Johannes. <i>Dyson Equation and Eigenvalue Statistics of Random Matrices</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1040\">10.15479/AT:ISTA:TH_1040</a>.","chicago":"Alt, Johannes. “Dyson Equation and Eigenvalue Statistics of Random Matrices.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1040\">https://doi.org/10.15479/AT:ISTA:TH_1040</a>.","ieee":"J. Alt, “Dyson equation and eigenvalue statistics of random matrices,” Institute of Science and Technology Austria, 2018.","ama":"Alt J. Dyson equation and eigenvalue statistics of random matrices. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1040\">10.15479/AT:ISTA:TH_1040</a>","short":"J. Alt, Dyson Equation and Eigenvalue Statistics of Random Matrices, Institute of Science and Technology Austria, 2018."},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2020-07-14T12:44:57Z","author":[{"first_name":"Johannes","id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87","full_name":"Alt, Johannes","last_name":"Alt"}],"type":"dissertation","publication_identifier":{"issn":["2663-337X"]},"file":[{"file_size":5801709,"date_updated":"2020-07-14T12:44:57Z","file_name":"2018_thesis_Alt.pdf","creator":"dernst","file_id":"6241","checksum":"d4dad55a7513f345706aaaba90cb1bb8","relation":"main_file","content_type":"application/pdf","date_created":"2019-04-08T13:55:20Z","access_level":"open_access"},{"content_type":"application/zip","date_created":"2019-04-08T13:55:20Z","access_level":"closed","checksum":"d73fcf46300dce74c403f2b491148ab4","relation":"source_file","file_id":"6242","creator":"dernst","file_size":3802059,"date_updated":"2020-07-14T12:44:57Z","file_name":"2018_thesis_Alt_source.zip"}],"pubrep_id":"1040","publisher":"Institute of Science and Technology Austria","ddc":["515","519"],"oa":1,"language":[{"iso":"eng"}],"page":"456"},{"citation":{"mla":"Ibsen-Jensen, Rasmus, et al. “Language Acquisition with Communication between Learners.” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 140, 20180073, Royal Society, 2018, doi:<a href=\"https://doi.org/10.1098/rsif.2018.0073\">10.1098/rsif.2018.0073</a>.","ista":"Ibsen-Jensen R, Tkadlec J, Chatterjee K, Nowak M. 2018. Language acquisition with communication between learners. Journal of the Royal Society Interface. 15(140), 20180073.","apa":"Ibsen-Jensen, R., Tkadlec, J., Chatterjee, K., &#38; Nowak, M. (2018). Language acquisition with communication between learners. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2018.0073\">https://doi.org/10.1098/rsif.2018.0073</a>","chicago":"Ibsen-Jensen, Rasmus, Josef Tkadlec, Krishnendu Chatterjee, and Martin Nowak. “Language Acquisition with Communication between Learners.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2018. <a href=\"https://doi.org/10.1098/rsif.2018.0073\">https://doi.org/10.1098/rsif.2018.0073</a>.","ama":"Ibsen-Jensen R, Tkadlec J, Chatterjee K, Nowak M. Language acquisition with communication between learners. <i>Journal of the Royal Society Interface</i>. 2018;15(140). doi:<a href=\"https://doi.org/10.1098/rsif.2018.0073\">10.1098/rsif.2018.0073</a>","ieee":"R. Ibsen-Jensen, J. Tkadlec, K. Chatterjee, and M. Nowak, “Language acquisition with communication between learners,” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 140. Royal Society, 2018.","short":"R. Ibsen-Jensen, J. Tkadlec, K. Chatterjee, M. Nowak, Journal of the Royal Society Interface 15 (2018)."},"author":[{"last_name":"Ibsen-Jensen","full_name":"Ibsen-Jensen, Rasmus","orcid":"0000-0003-4783-0389","id":"3B699956-F248-11E8-B48F-1D18A9856A87","first_name":"Rasmus"},{"last_name":"Tkadlec","first_name":"Josef","id":"3F24CCC8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1097-9684","full_name":"Tkadlec, Josef"},{"first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee"},{"first_name":"Martin","full_name":"Nowak, Martin","last_name":"Nowak"}],"file_date_updated":"2020-07-14T12:45:22Z","type":"journal_article","issue":"140","article_number":"20180073","file":[{"file_size":219837,"date_updated":"2020-07-14T12:45:22Z","file_name":"2018_RS_IbsenJensen.pdf","creator":"dernst","file_id":"5955","checksum":"444e1a9d98eb0e780671be82b13025f3","relation":"main_file","access_level":"open_access","date_created":"2019-02-12T07:54:37Z","content_type":"application/pdf"}],"publication_identifier":{"eissn":["1742-5662"]},"volume":15,"oa":1,"language":[{"iso":"eng"}],"publisher":"Royal Society","ddc":["000"],"external_id":{"isi":["000428576200023"],"pmid":["29593089"]},"department":[{"_id":"KrCh"}],"project":[{"_id":"2581B60A-B435-11E9-9278-68D0E5697425","grant_number":"279307","name":"Quantitative Graph Games: Theory and Applications","call_identifier":"FP7"},{"call_identifier":"FWF","name":"Modern Graph Algorithmic Techniques in Formal Verification","grant_number":"P 23499-N23","_id":"2584A770-B435-11E9-9278-68D0E5697425"},{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","grant_number":"S 11407_N23","name":"Rigorous Systems Engineering","call_identifier":"FWF"}],"_id":"198","ec_funded":1,"abstract":[{"lang":"eng","text":"We consider a class of students learning a language from a teacher. The situation can be interpreted as a group of child learners receiving input from the linguistic environment. The teacher provides sample sentences. The students try to learn the grammar from the teacher. In addition to just listening to the teacher, the students can also communicate with each other. The students hold hypotheses about the grammar and change them if they receive counter evidence. The process stops when all students have converged to the correct grammar. We study how the time to convergence depends on the structure of the classroom by introducing and evaluating various complexity measures. We find that structured communication between students, although potentially introducing confusion, can greatly reduce some of the complexity measures. Our theory can also be interpreted as applying to the scientific process, where nature is the teacher and the scientists are the students."}],"oa_version":"Submitted Version","related_material":{"link":[{"relation":"supplementary_material","url":"https://dx.doi.org/10.6084/m9.figshare.c.4028971"}],"record":[{"status":"public","id":"9814","relation":"research_data"}]},"month":"03","day":"01","isi":1,"status":"public","title":"Language acquisition with communication between learners","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","year":"2018","date_created":"2018-12-11T11:45:09Z","publication_status":"published","article_type":"original","fulldoi":"https://doi.org/10.1098/rsif.2018.0073","doi":"10.1098/rsif.2018.0073","scopus_import":"1","article_processing_charge":"No","publication":"Journal of the Royal Society Interface","pmid":1,"date_published":"2018-03-01T00:00:00Z","publist_id":"7715","intvolume":"        15","quality_controlled":"1","date_updated":"2026-08-12T14:08:29Z"},{"_id":"52","abstract":[{"lang":"eng","text":"In this thesis we will discuss systems of point interacting fermions, their stability and other spectral properties. Whereas for bosons a point interacting system is always unstable this ques- tion is more subtle for a gas of two species of fermions. In particular the answer depends on the mass ratio between these two species. Most of this work will be focused on the N + M model which consists of two species of fermions with N, M particles respectively which interact via point interactions. We will introduce this model using a formal limit and discuss the N + 1 system in more detail. In particular, we will show that for mass ratios above a critical one, which does not depend on the particle number, the N + 1 system is stable. In the context of this model we will prove rigorous versions of Tan relations which relate various quantities of the point-interacting model. By restricting the N + 1 system to a box we define a finite density model with point in- teractions. In the context of this system we will discuss the energy change when introducing a point-interacting impurity into a system of non-interacting fermions. We will see that this change in energy is bounded independently of the particle number and in particular the bound only depends on the density and the scattering length. As another special case of the N + M model we will show stability of the 2 + 2 model for mass ratios in an interval around one. Further we will investigate a different model of point interactions which was discussed before in the literature and which is, contrary to the N + M model, not given by a limiting procedure but is based on a Dirichlet form. We will show that this system behaves trivially in the thermodynamic limit, i.e. the free energy per particle is the same as the one of the non-interacting system."}],"oa_version":"Published Version","department":[{"_id":"RoSe"}],"project":[{"grant_number":"P27533_N27","_id":"25C878CE-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems"}],"alternative_title":["ISTA Thesis"],"has_accepted_license":"1","OA_place":"publisher","degree_awarded":"PhD","title":"Point interactions in systems of fermions","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","corr_author":"1","month":"09","day":"04","related_material":{"record":[{"id":"5856","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"741"},{"id":"1198","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"154","relation":"part_of_dissertation"}]},"status":"public","article_processing_charge":"No","supervisor":[{"last_name":"Seiringer","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:th_1043","doi":"10.15479/AT:ISTA:th_1043","date_created":"2018-12-11T11:44:22Z","publication_status":"published","year":"2018","date_updated":"2026-08-12T14:12:55Z","publist_id":"8002","date_published":"2018-09-04T00:00:00Z","author":[{"last_name":"Moser","first_name":"Thomas","id":"2B5FC9A4-F248-11E8-B48F-1D18A9856A87","full_name":"Moser, Thomas"}],"file_date_updated":"2020-07-14T12:46:37Z","citation":{"mla":"Moser, Thomas. <i>Point Interactions in Systems of Fermions</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">10.15479/AT:ISTA:th_1043</a>.","ista":"Moser T. 2018. Point interactions in systems of fermions. Institute of Science and Technology Austria.","apa":"Moser, T. (2018). <i>Point interactions in systems of fermions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">https://doi.org/10.15479/AT:ISTA:th_1043</a>","chicago":"Moser, Thomas. “Point Interactions in Systems of Fermions.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">https://doi.org/10.15479/AT:ISTA:th_1043</a>.","ama":"Moser T. Point interactions in systems of fermions. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">10.15479/AT:ISTA:th_1043</a>","ieee":"T. Moser, “Point interactions in systems of fermions,” Institute of Science and Technology Austria, 2018.","short":"T. Moser, Point Interactions in Systems of Fermions, Institute of Science and Technology Austria, 2018."},"type":"dissertation","publication_identifier":{"issn":["2663-337X"]},"file":[{"relation":"main_file","checksum":"fbd8c747d148b468a21213b7cf175225","content_type":"application/pdf","access_level":"open_access","date_created":"2019-04-09T07:45:38Z","file_name":"2018_Thesis_Moser.pdf","date_updated":"2020-07-14T12:46:37Z","file_size":851164,"file_id":"6256","creator":"dernst"},{"checksum":"c28e16ecfc1126d3ce324ec96493c01e","relation":"source_file","access_level":"closed","date_created":"2019-04-09T07:45:38Z","content_type":"application/zip","file_size":1531516,"date_updated":"2020-07-14T12:46:37Z","file_name":"2018_Thesis_Moser_Source.zip","creator":"dernst","file_id":"6257"}],"ddc":["515","530","519"],"publisher":"Institute of Science and Technology Austria","pubrep_id":"1043","page":"115","language":[{"iso":"eng"}],"oa":1},{"citation":{"short":"T. Moser, R. Seiringer, Mathematical Physics, Analysis and Geometry 21 (2018).","ama":"Moser T, Seiringer R. Stability of the 2+2 fermionic system with point interactions. <i>Mathematical Physics, Analysis and Geometry</i>. 2018;21(3). doi:<a href=\"https://doi.org/10.1007/s11040-018-9275-3\">10.1007/s11040-018-9275-3</a>","ieee":"T. Moser and R. Seiringer, “Stability of the 2+2 fermionic system with point interactions,” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 21, no. 3. Springer, 2018.","chicago":"Moser, Thomas, and Robert Seiringer. “Stability of the 2+2 Fermionic System with Point Interactions.” <i>Mathematical Physics, Analysis and Geometry</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s11040-018-9275-3\">https://doi.org/10.1007/s11040-018-9275-3</a>.","apa":"Moser, T., &#38; Seiringer, R. (2018). Stability of the 2+2 fermionic system with point interactions. <i>Mathematical Physics, Analysis and Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s11040-018-9275-3\">https://doi.org/10.1007/s11040-018-9275-3</a>","ista":"Moser T, Seiringer R. 2018. Stability of the 2+2 fermionic system with point interactions. Mathematical Physics, Analysis and Geometry. 21(3), 19.","mla":"Moser, Thomas, and Robert Seiringer. “Stability of the 2+2 Fermionic System with Point Interactions.” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 21, no. 3, 19, Springer, 2018, doi:<a href=\"https://doi.org/10.1007/s11040-018-9275-3\">10.1007/s11040-018-9275-3</a>."},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"author":[{"full_name":"Moser, Thomas","id":"2B5FC9A4-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas","last_name":"Moser"},{"first_name":"Robert","full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer"}],"file_date_updated":"2020-07-14T12:45:01Z","issue":"3","type":"journal_article","article_number":"19","publication_identifier":{"issn":["1385-0172"],"eissn":["1572-9656"]},"volume":21,"acknowledgement":"Open access funding provided by Austrian Science Fund (FWF).","file":[{"creator":"dernst","file_id":"5729","file_size":496973,"date_updated":"2020-07-14T12:45:01Z","file_name":"2018_MathPhysics_Moser.pdf","content_type":"application/pdf","date_created":"2018-12-17T16:49:02Z","access_level":"open_access","checksum":"411c4db5700d7297c9cd8ebc5dd29091","relation":"main_file"}],"publisher":"Springer","ddc":["530"],"oa":1,"language":[{"iso":"eng"}],"department":[{"_id":"RoSe"}],"project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","grant_number":"694227","name":"Analysis of quantum many-body systems","call_identifier":"H2020"},{"call_identifier":"FWF","name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems","grant_number":"P27533_N27","_id":"25C878CE-B435-11E9-9278-68D0E5697425"},{"_id":"3AC91DDA-15DF-11EA-824D-93A3E7B544D1","name":"FWF Open Access Fund","call_identifier":"FWF"}],"_id":"154","ec_funded":1,"abstract":[{"lang":"eng","text":"We give a lower bound on the ground state energy of a system of two fermions of one species interacting with two fermions of another species via point interactions. We show that there is a critical mass ratio m2 ≈ 0.58 such that the system is stable, i.e., the energy is bounded from below, for m∈[m2,m2−1]. So far it was not known whether this 2 + 2 system exhibits a stable region at all or whether the formation of four-body bound states causes an unbounded spectrum for all mass ratios, similar to the Thomas effect. Our result gives further evidence for the stability of the more general N + M system."}],"oa_version":"Published Version","external_id":{"isi":["000439639700001"]},"title":"Stability of the 2+2 fermionic system with point interactions","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","day":"01","month":"09","related_material":{"record":[{"status":"public","id":"52","relation":"dissertation_contains"}]},"isi":1,"status":"public","fulldoi":"https://doi.org/10.1007/s11040-018-9275-3","doi":"10.1007/s11040-018-9275-3","article_processing_charge":"No","scopus_import":"1","year":"2018","article_type":"original","date_created":"2018-12-11T11:44:55Z","publication_status":"published","publist_id":"7767","intvolume":"        21","quality_controlled":"1","date_updated":"2026-08-12T14:12:56Z","publication":"Mathematical Physics, Analysis and Geometry","date_published":"2018-09-01T00:00:00Z"},{"external_id":{"isi":["000456469400103"]},"oa_version":"None","author":[{"last_name":"Masís","first_name":"Javier","full_name":"Masís, Javier"},{"last_name":"Mankus","full_name":"Mankus, David","first_name":"David"},{"last_name":"Wolff","full_name":"Wolff, Steffen","first_name":"Steffen"},{"first_name":"Grigori","full_name":"Guitchounts, Grigori","last_name":"Guitchounts"},{"id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","full_name":"Jösch, Maximilian A","orcid":"0000-0002-3937-1330","first_name":"Maximilian A","last_name":"Jösch"},{"last_name":"Cox","first_name":"David","full_name":"Cox, David"}],"_id":"6","abstract":[{"lang":"eng","text":"Lesion and electrode location verification are traditionally done via histological examination of stained brain slices, a time-consuming procedure that requires manual estimation. Here, we describe a simple, straightforward method for quantifying lesions and locating electrodes in the brain that is less laborious and yields more detailed results. Whole brains are stained with osmium tetroxide, embedded in resin, and imaged with a micro-CT scanner. The scans result in 3D digital volumes of the brains with resolutions and virtual section thicknesses dependent on the sample size (12-15 and 5-6 µm per voxel for rat and zebra finch brains, respectively). Surface and deep lesions can be characterized, and single tetrodes, tetrode arrays, electrolytic lesions, and silicon probes can also be localized. Free and proprietary software allows experimenters to examine the sample volume from any plane and segment the volume manually or automatically. Because this method generates whole brain volume, lesions and electrodes can be quantified to a much higher degree than in current methods, which will help standardize comparisons within and across studies."}],"department":[{"_id":"MaJö"}],"citation":{"ieee":"J. Masís, D. Mankus, S. Wolff, G. Guitchounts, M. A. Jösch, and D. Cox, “A micro-CT-based method for characterising lesions and locating electrodes in small animal brains,” <i>Journal of Visualized Experiments</i>, vol. 141. MyJove Corporation, 2018.","ama":"Masís J, Mankus D, Wolff S, Guitchounts G, Jösch MA, Cox D. A micro-CT-based method for characterising lesions and locating electrodes in small animal brains. <i>Journal of Visualized Experiments</i>. 2018;141. doi:<a href=\"https://doi.org/10.3791/58585\">10.3791/58585</a>","short":"J. Masís, D. Mankus, S. Wolff, G. Guitchounts, M.A. Jösch, D. Cox, Journal of Visualized Experiments 141 (2018).","apa":"Masís, J., Mankus, D., Wolff, S., Guitchounts, G., Jösch, M. A., &#38; Cox, D. (2018). A micro-CT-based method for characterising lesions and locating electrodes in small animal brains. <i>Journal of Visualized Experiments</i>. MyJove Corporation. <a href=\"https://doi.org/10.3791/58585\">https://doi.org/10.3791/58585</a>","ista":"Masís J, Mankus D, Wolff S, Guitchounts G, Jösch MA, Cox D. 2018. A micro-CT-based method for characterising lesions and locating electrodes in small animal brains. Journal of Visualized Experiments. 141.","mla":"Masís, Javier, et al. “A Micro-CT-Based Method for Characterising Lesions and Locating Electrodes in Small Animal Brains.” <i>Journal of Visualized Experiments</i>, vol. 141, MyJove Corporation, 2018, doi:<a href=\"https://doi.org/10.3791/58585\">10.3791/58585</a>.","chicago":"Masís, Javier, David Mankus, Steffen Wolff, Grigori Guitchounts, Maximilian A Jösch, and David Cox. “A Micro-CT-Based Method for Characterising Lesions and Locating Electrodes in Small Animal Brains.” <i>Journal of Visualized Experiments</i>. MyJove Corporation, 2018. <a href=\"https://doi.org/10.3791/58585\">https://doi.org/10.3791/58585</a>."},"status":"public","isi":1,"day":"08","month":"11","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"A micro-CT-based method for characterising lesions and locating electrodes in small animal brains","type":"journal_article","publication_status":"published","date_created":"2018-12-11T11:44:07Z","year":"2018","volume":141,"scopus_import":"1","article_processing_charge":"No","doi":"10.3791/58585","fulldoi":"https://doi.org/10.3791/58585","date_published":"2018-11-08T00:00:00Z","language":[{"iso":"eng"}],"publication":"Journal of Visualized Experiments","date_updated":"2026-08-12T14:10:17Z","quality_controlled":"1","publisher":"MyJove Corporation","intvolume":"       141","publist_id":"8050"},{"fulldoi":"https://doi.org/10.1103/PhysRevA.97.043842","doi":"10.1103/PhysRevA.97.043842","article_processing_charge":"No","scopus_import":"1","year":"2018","publication_status":"published","date_created":"2018-12-11T11:45:40Z","publist_id":"7587","intvolume":"        97","quality_controlled":"1","date_updated":"2026-08-12T14:22:13Z","publication":"Physical Review A","date_published":"2018-04-18T00:00:00Z","department":[{"_id":"MiLe"}],"project":[{"grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme"}],"ec_funded":1,"_id":"294","abstract":[{"lang":"eng","text":"We developed a method to calculate two-photon processes in quantum mechanics that replaces the infinite summation over the intermediate states by a perturbation expansion. This latter consists of a series of commutators that involve position, momentum, and Hamiltonian quantum operators. We analyzed several single- and many-particle cases for which a closed-form solution to the perturbation expansion exists, as well as more complicated cases for which a solution is found by convergence. Throughout the article, Rayleigh and Raman scattering are taken as examples of two-photon processes. The present method provides a clear distinction between the Thomson scattering, regarded as classical scattering, and quantum contributions. Such a distinction lets us derive general results concerning light scattering. Finally, possible extensions to the developed formalism are discussed."}],"oa_version":"Submitted Version","external_id":{"isi":["000430296800008"],"arxiv":["1801.06892"]},"title":"Two-photon processes based on quantum commutators","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"04","day":"18","status":"public","isi":1,"volume":97,"publisher":"American Physical Society","arxiv":1,"oa":1,"language":[{"iso":"eng"}],"citation":{"chicago":"Fratini, Filippo, Laleh Safari, Pedro Amaro, and José Santos. “Two-Photon Processes Based on Quantum Commutators.” <i>Physical Review A</i>. American Physical Society, 2018. <a href=\"https://doi.org/10.1103/PhysRevA.97.043842\">https://doi.org/10.1103/PhysRevA.97.043842</a>.","mla":"Fratini, Filippo, et al. “Two-Photon Processes Based on Quantum Commutators.” <i>Physical Review A</i>, vol. 97, no. 4, American Physical Society, 2018, doi:<a href=\"https://doi.org/10.1103/PhysRevA.97.043842\">10.1103/PhysRevA.97.043842</a>.","ista":"Fratini F, Safari L, Amaro P, Santos J. 2018. Two-photon processes based on quantum commutators. Physical Review A. 97(4).","apa":"Fratini, F., Safari, L., Amaro, P., &#38; Santos, J. (2018). Two-photon processes based on quantum commutators. <i>Physical Review A</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevA.97.043842\">https://doi.org/10.1103/PhysRevA.97.043842</a>","short":"F. Fratini, L. Safari, P. Amaro, J. Santos, Physical Review A 97 (2018).","ama":"Fratini F, Safari L, Amaro P, Santos J. Two-photon processes based on quantum commutators. <i>Physical Review A</i>. 2018;97(4). doi:<a href=\"https://doi.org/10.1103/PhysRevA.97.043842\">10.1103/PhysRevA.97.043842</a>","ieee":"F. Fratini, L. Safari, P. Amaro, and J. Santos, “Two-photon processes based on quantum commutators,” <i>Physical Review A</i>, vol. 97, no. 4. American Physical Society, 2018."},"author":[{"last_name":"Fratini","full_name":"Fratini, Filippo","first_name":"Filippo"},{"first_name":"Laleh","full_name":"Safari, Laleh","id":"3C325E5E-F248-11E8-B48F-1D18A9856A87","last_name":"Safari"},{"last_name":"Amaro","full_name":"Amaro, Pedro","first_name":"Pedro"},{"last_name":"Santos","full_name":"Santos, José","first_name":"José"}],"issue":"4","type":"journal_article","main_file_link":[{"url":"https://arxiv.org/abs/1801.06892","open_access":"1"}]},{"project":[{"call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","name":"Quantum rotations in the presence of a many-body environment","grant_number":"P29902","_id":"26031614-B435-11E9-9278-68D0E5697425"}],"department":[{"_id":"MiLe"}],"ec_funded":1,"_id":"195","abstract":[{"text":"We demonstrate that identical impurities immersed in a two-dimensional many-particle bath can be viewed as flux-tube-charged-particle composites described by fractional statistics. In particular, we find that the bath manifests itself as an external magnetic flux tube with respect to the impurities, and hence the time-reversal symmetry is broken for the effective Hamiltonian describing the impurities. The emerging flux tube acts as a statistical gauge field after a certain critical coupling. This critical coupling corresponds to the intersection point between the quasiparticle state and the phonon wing, where the angular momentum is transferred from the impurity to the bath. This amounts to a novel configuration with emerging anyons. The proposed setup paves the way to realizing anyons using electrons interacting with superfluid helium or lattice phonons, as well as using atomic impurities in ultracold gases.","lang":"eng"}],"oa_version":"Submitted Version","external_id":{"isi":["000436939100007"],"arxiv":["1712.00308"]},"title":"Anyonic statistics of quantum impurities in two dimensions","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"15","month":"07","isi":1,"status":"public","corr_author":"1","fulldoi":"https://doi.org/10.1103/PhysRevB.98.045402","doi":"10.1103/PhysRevB.98.045402","scopus_import":"1","article_processing_charge":"No","year":"2018","publication_status":"published","date_created":"2018-12-11T11:45:08Z","intvolume":"        98","date_updated":"2026-08-12T14:24:49Z","quality_controlled":"1","publication":"Physical Review B","date_published":"2018-07-15T00:00:00Z","citation":{"chicago":"Yakaboylu, Enderalp, and Mikhail Lemeshko. “Anyonic Statistics of Quantum Impurities in Two Dimensions.” <i>Physical Review B</i>. American Physical Society, 2018. <a href=\"https://doi.org/10.1103/PhysRevB.98.045402\">https://doi.org/10.1103/PhysRevB.98.045402</a>.","ista":"Yakaboylu E, Lemeshko M. 2018. Anyonic statistics of quantum impurities in two dimensions. Physical Review B. 98(4), 045402.","mla":"Yakaboylu, Enderalp, and Mikhail Lemeshko. “Anyonic Statistics of Quantum Impurities in Two Dimensions.” <i>Physical Review B</i>, vol. 98, no. 4, 045402, American Physical Society, 2018, doi:<a href=\"https://doi.org/10.1103/PhysRevB.98.045402\">10.1103/PhysRevB.98.045402</a>.","apa":"Yakaboylu, E., &#38; Lemeshko, M. (2018). Anyonic statistics of quantum impurities in two dimensions. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.98.045402\">https://doi.org/10.1103/PhysRevB.98.045402</a>","short":"E. Yakaboylu, M. Lemeshko, Physical Review B 98 (2018).","ama":"Yakaboylu E, Lemeshko M. Anyonic statistics of quantum impurities in two dimensions. <i>Physical Review B</i>. 2018;98(4). doi:<a href=\"https://doi.org/10.1103/PhysRevB.98.045402\">10.1103/PhysRevB.98.045402</a>","ieee":"E. Yakaboylu and M. Lemeshko, “Anyonic statistics of quantum impurities in two dimensions,” <i>Physical Review B</i>, vol. 98, no. 4. American Physical Society, 2018."},"author":[{"last_name":"Yakaboylu","id":"38CB71F6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5973-0874","full_name":"Yakaboylu, Enderalp","first_name":"Enderalp"},{"last_name":"Lemeshko","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","full_name":"Lemeshko, Mikhail","orcid":"0000-0002-6990-7802","first_name":"Mikhail"}],"issue":"4","type":"journal_article","article_number":"045402","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1712.00308"}],"volume":98,"publisher":"American Physical Society","arxiv":1,"oa":1,"language":[{"iso":"eng"}]},{"citation":{"ama":"Erdös L, Mühlbacher P. Bounds on the norm of Wigner-type random matrices. <i>Random Matrices: Theory and Applications</i>. 2018. doi:<a href=\"https://doi.org/10.1142/s2010326319500096\">10.1142/s2010326319500096</a>","ieee":"L. Erdös and P. Mühlbacher, “Bounds on the norm of Wigner-type random matrices,” <i>Random Matrices: Theory and Applications</i>. World Scientific Publishing, 2018.","short":"L. Erdös, P. Mühlbacher, Random Matrices: Theory and Applications (2018).","ista":"Erdös L, Mühlbacher P. 2018. Bounds on the norm of Wigner-type random matrices. Random Matrices: Theory and Applications., 1950009.","mla":"Erdös, László, and Peter Mühlbacher. “Bounds on the Norm of Wigner-Type Random Matrices.” <i>Random Matrices: Theory and Applications</i>, 1950009, World Scientific Publishing, 2018, doi:<a href=\"https://doi.org/10.1142/s2010326319500096\">10.1142/s2010326319500096</a>.","apa":"Erdös, L., &#38; Mühlbacher, P. (2018). Bounds on the norm of Wigner-type random matrices. <i>Random Matrices: Theory and Applications</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/s2010326319500096\">https://doi.org/10.1142/s2010326319500096</a>","chicago":"Erdös, László, and Peter Mühlbacher. “Bounds on the Norm of Wigner-Type Random Matrices.” <i>Random Matrices: Theory and Applications</i>. World Scientific Publishing, 2018. <a href=\"https://doi.org/10.1142/s2010326319500096\">https://doi.org/10.1142/s2010326319500096</a>."},"author":[{"last_name":"Erdös","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László"},{"last_name":"Mühlbacher","full_name":"Mühlbacher, Peter","first_name":"Peter"}],"type":"journal_article","main_file_link":[{"url":"https://arxiv.org/abs/1802.05175","open_access":"1"}],"article_number":"1950009","publication_identifier":{"eissn":["2010-3271"],"issn":["2010-3263"]},"oa":1,"language":[{"iso":"eng"}],"arxiv":1,"publisher":"World Scientific Publishing","external_id":{"isi":["000477677200002"],"arxiv":["1802.05175"]},"department":[{"_id":"LaEr"}],"project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7"}],"oa_version":"Preprint","_id":"5971","abstract":[{"lang":"eng","text":"We consider a Wigner-type ensemble, i.e. large hermitian N×N random matrices H=H∗ with centered independent entries and with a general matrix of variances Sxy=𝔼∣∣Hxy∣∣2. The norm of H is asymptotically given by the maximum of the support of the self-consistent density of states. We establish a bound on this maximum in terms of norms of powers of S that substantially improves the earlier bound 2∥S∥1/2∞ given in [O. Ajanki, L. Erdős and T. Krüger, Universality for general Wigner-type matrices, Prob. Theor. Rel. Fields169 (2017) 667–727]. The key element of the proof is an effective Markov chain approximation for the contributions of the weighted Dyck paths appearing in the iterative solution of the corresponding Dyson equation."}],"ec_funded":1,"isi":1,"status":"public","month":"09","day":"26","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Bounds on the norm of Wigner-type random matrices","year":"2018","date_created":"2019-02-13T10:40:54Z","publication_status":"published","doi":"10.1142/s2010326319500096","fulldoi":"https://doi.org/10.1142/s2010326319500096","scopus_import":"1","article_processing_charge":"No","publication":"Random Matrices: Theory and Applications","date_published":"2018-09-26T00:00:00Z","quality_controlled":"1","date_updated":"2026-08-12T14:33:01Z"},{"date_created":"2019-02-13T13:32:48Z","publication_status":"published","year":"2018","scopus_import":"1","article_processing_charge":"No","doi":"10.1609/aaai.v32i1.12202","fulldoi":"https://doi.org/10.1609/aaai.v32i1.12202","date_published":"2018-02-01T00:00:00Z","publication":"Proceedings of the 32st AAAI Conference on Artificial Intelligence","quality_controlled":"1","date_updated":"2026-08-19T09:30:58Z","external_id":{"isi":["000485488906082"],"arxiv":["2004.06370"]},"oa_version":"Preprint","_id":"5978","abstract":[{"lang":"eng","text":"We consider the MAP-inference problem for graphical models,which is a valued constraint satisfaction problem defined onreal numbers with a natural summation operation. We proposea family of relaxations (different from the famous Sherali-Adams hierarchy), which naturally define lower bounds for itsoptimum. This family always contains a tight relaxation andwe give an algorithm able to find it and therefore, solve theinitial non-relaxed NP-hard problem.The relaxations we consider decompose the original probleminto two non-overlapping parts: an easy LP-tight part and adifficult one. For the latter part a combinatorial solver must beused. As we show in our experiments, in a number of applica-tions the second, difficult part constitutes only a small fractionof the whole problem. This property allows to significantlyreduce the computational time of the combinatorial solver andtherefore solve problems which were out of reach before."}],"department":[{"_id":"VlKo"}],"status":"public","isi":1,"day":"01","month":"02","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Exact MAP-inference by confining combinatorial search with LP relaxation","page":"6581-6588","language":[{"iso":"eng"}],"oa":1,"arxiv":1,"publisher":"AAAI Press","author":[{"first_name":"Stefan","full_name":"Haller, Stefan","last_name":"Haller"},{"last_name":"Swoboda","id":"446560C6-F248-11E8-B48F-1D18A9856A87","full_name":"Swoboda, Paul","first_name":"Paul"},{"full_name":"Savchynskyy, Bogdan","first_name":"Bogdan","last_name":"Savchynskyy"}],"conference":{"location":"New Orleans, LU, United States","start_date":"2018-02-02","name":"AAAI: Conference on Artificial Intelligence","end_date":"2018-02-07"},"citation":{"chicago":"Haller, Stefan, Paul Swoboda, and Bogdan Savchynskyy. “Exact MAP-Inference by Confining Combinatorial Search with LP Relaxation.” In <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i>, 6581–88. AAAI Press, 2018. <a href=\"https://doi.org/10.1609/aaai.v32i1.12202\">https://doi.org/10.1609/aaai.v32i1.12202</a>.","apa":"Haller, S., Swoboda, P., &#38; Savchynskyy, B. (2018). Exact MAP-inference by confining combinatorial search with LP relaxation. In <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i> (pp. 6581–6588). New Orleans, LU, United States: AAAI Press. <a href=\"https://doi.org/10.1609/aaai.v32i1.12202\">https://doi.org/10.1609/aaai.v32i1.12202</a>","mla":"Haller, Stefan, et al. “Exact MAP-Inference by Confining Combinatorial Search with LP Relaxation.” <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i>, AAAI Press, 2018, pp. 6581–88, doi:<a href=\"https://doi.org/10.1609/aaai.v32i1.12202\">10.1609/aaai.v32i1.12202</a>.","ista":"Haller S, Swoboda P, Savchynskyy B. 2018. Exact MAP-inference by confining combinatorial search with LP relaxation. Proceedings of the 32st AAAI Conference on Artificial Intelligence. AAAI: Conference on Artificial Intelligence, 6581–6588.","short":"S. Haller, P. Swoboda, B. Savchynskyy, in:, Proceedings of the 32st AAAI Conference on Artificial Intelligence, AAAI Press, 2018, pp. 6581–6588.","ama":"Haller S, Swoboda P, Savchynskyy B. Exact MAP-inference by confining combinatorial search with LP relaxation. In: <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i>. AAAI Press; 2018:6581-6588. doi:<a href=\"https://doi.org/10.1609/aaai.v32i1.12202\">10.1609/aaai.v32i1.12202</a>","ieee":"S. Haller, P. Swoboda, and B. Savchynskyy, “Exact MAP-inference by confining combinatorial search with LP relaxation,” in <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i>, New Orleans, LU, United States, 2018, pp. 6581–6588."},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2004.06370"}],"type":"conference"},{"related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/mutation-that-causes-autism-and-intellectual-disability-makes-brain-less-flexible/","relation":"press_release"}],"record":[{"relation":"popular_science","id":"6074","status":"public"},{"id":"12364","relation":"dissertation_contains","status":"public"}]},"day":"19","month":"11","isi":1,"status":"public","corr_author":"1","title":"Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","has_accepted_license":"1","external_id":{"isi":["000451324700010"]},"department":[{"_id":"GaNo"},{"_id":"EdHa"}],"project":[{"name":"Probing development and reversibility of autism spectrum disorders","_id":"254BA948-B435-11E9-9278-68D0E5697425","grant_number":"401299"}],"_id":"3","abstract":[{"lang":"eng","text":"SETD5 gene mutations have been identified as a frequent cause of idiopathic intellectual disability. Here we show that Setd5-haploinsufficient mice present developmental defects such as abnormal brain-to-body weight ratios and neural crest defect-associated phenotypes. Furthermore, Setd5-mutant mice show impairments in cognitive tasks, enhanced long-term potentiation, delayed ontogenetic profile of ultrasonic vocalization, and behavioral inflexibility. Behavioral issues are accompanied by abnormal expression of postsynaptic density proteins previously associated with cognition. Our data additionally indicate that Setd5 regulates RNA polymerase II dynamics and gene transcription via its interaction with the Hdac3 and Paf1 complexes, findings potentially explaining the gene expression defects observed in Setd5-haploinsufficient mice. Our results emphasize the decisive role of Setd5 in a biological pathway found to be disrupted in humans with intellectual disability and autism spectrum disorder."}],"oa_version":"Submitted Version","publication":"Nature Neuroscience","date_published":"2018-11-19T00:00:00Z","publist_id":"8054","intvolume":"        21","quality_controlled":"1","date_updated":"2026-10-04T22:30:09Z","year":"2018","date_created":"2018-12-11T11:44:05Z","article_type":"original","publication_status":"published","fulldoi":"https://doi.org/10.1038/s41593-018-0266-2","doi":"10.1038/s41593-018-0266-2","article_processing_charge":"No","scopus_import":"1","type":"journal_article","issue":"12","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"PreCl"}],"citation":{"ama":"Deliu E, Arecco N, Morandell J, et al. Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. <i>Nature Neuroscience</i>. 2018;21(12):1717-1727. doi:<a href=\"https://doi.org/10.1038/s41593-018-0266-2\">10.1038/s41593-018-0266-2</a>","ieee":"E. Deliu <i>et al.</i>, “Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition,” <i>Nature Neuroscience</i>, vol. 21, no. 12. Nature Publishing Group, pp. 1717–1727, 2018.","short":"E. Deliu, N. Arecco, J. Morandell, C. Dotter, X. Contreras, C. Girardot, E. Käsper, A. Kozlova, K. Kishi, I. Chiaradia, K. Noh, G. Novarino, Nature Neuroscience 21 (2018) 1717–1727.","apa":"Deliu, E., Arecco, N., Morandell, J., Dotter, C., Contreras, X., Girardot, C., … Novarino, G. (2018). Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41593-018-0266-2\">https://doi.org/10.1038/s41593-018-0266-2</a>","ista":"Deliu E, Arecco N, Morandell J, Dotter C, Contreras X, Girardot C, Käsper E, Kozlova A, Kishi K, Chiaradia I, Noh K, Novarino G. 2018. Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. Nature Neuroscience. 21(12), 1717–1727.","mla":"Deliu, Elena, et al. “Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature Neuroscience</i>, vol. 21, no. 12, Nature Publishing Group, 2018, pp. 1717–27, doi:<a href=\"https://doi.org/10.1038/s41593-018-0266-2\">10.1038/s41593-018-0266-2</a>.","chicago":"Deliu, Elena, Niccoló Arecco, Jasmin Morandell, Christoph Dotter, Ximena Contreras, Charles Girardot, Eva Käsper, et al. “Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41593-018-0266-2\">https://doi.org/10.1038/s41593-018-0266-2</a>."},"author":[{"first_name":"Elena","id":"37A40D7E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7370-5293","full_name":"Deliu, Elena","last_name":"Deliu"},{"last_name":"Arecco","first_name":"Niccoló","full_name":"Arecco, Niccoló"},{"last_name":"Morandell","full_name":"Morandell, Jasmin","id":"4739D480-F248-11E8-B48F-1D18A9856A87","first_name":"Jasmin"},{"last_name":"Dotter","id":"4C66542E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9033-9096","full_name":"Dotter, Christoph","first_name":"Christoph"},{"last_name":"Contreras","first_name":"Ximena","id":"475990FE-F248-11E8-B48F-1D18A9856A87","full_name":"Contreras, Ximena"},{"first_name":"Charles","full_name":"Girardot, Charles","last_name":"Girardot"},{"first_name":"Eva","full_name":"Käsper, Eva","last_name":"Käsper"},{"first_name":"Alena","id":"C50A9596-02D0-11E9-976E-E38CFE5CBC1D","full_name":"Kozlova, Alena","last_name":"Kozlova"},{"first_name":"Kasumi","id":"3065DFC4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6060-4795","full_name":"Kishi, Kasumi","last_name":"Kishi"},{"full_name":"Chiaradia, Ilaria","orcid":"0000-0002-9529-4464","id":"B6467F20-02D0-11E9-BDA5-E960C241894A","first_name":"Ilaria","last_name":"Chiaradia"},{"first_name":"Kyung","full_name":"Noh, Kyung","last_name":"Noh"},{"first_name":"Gaia","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino"}],"file_date_updated":"2020-07-14T12:45:58Z","language":[{"iso":"eng"}],"oa":1,"page":"1717 - 1727","pubrep_id":"1071","publisher":"Nature Publishing Group","ddc":["570"],"acknowledgement":"This work was supported by the Simons Foundation Autism Research Initiative (grant 401299) to G.N. and the DFG (SPP1738 grant NO 1249) to K.-M.N.","file":[{"file_id":"6255","creator":"dernst","file_size":8167169,"file_name":"2017_NatureNeuroscience_Deliu.pdf","date_updated":"2020-07-14T12:45:58Z","content_type":"application/pdf","date_created":"2019-04-09T07:41:57Z","access_level":"open_access","checksum":"60abd0f05b7cdc08a6b0ec460884084f","relation":"main_file"}],"volume":21},{"publist_id":"8029","date_updated":"2026-04-08T14:15:35Z","date_published":"2018-10-30T00:00:00Z","fulldoi":"https://doi.org/10.15479/AT:ISTA:th1059","doi":"10.15479/AT:ISTA:th1059","article_processing_charge":"No","supervisor":[{"last_name":"Guet","orcid":"0000-0001-6220-2052","full_name":"Guet, Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","first_name":"Calin C"}],"year":"2018","date_created":"2018-12-11T11:44:14Z","publication_status":"published","title":"The influence of sequence context on the evolution of bacterial gene expression","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","has_accepted_license":"1","degree_awarded":"PhD","month":"10","related_material":{"record":[{"status":"public","id":"704","relation":"part_of_dissertation"}]},"day":"30","status":"public","corr_author":"1","department":[{"_id":"CaGu"}],"abstract":[{"lang":"eng","text":"Expression of genes is a fundamental molecular phenotype that is subject to evolution by different types of mutations. Both the rate and the effect of mutations may depend on the DNA sequence context of a particular gene or a particular promoter sequence. In this thesis I investigate the nature of this dependence using simple genetic systems in Escherichia coli. With these systems I explore the evolution of constitutive gene expression from random starting sequences at different loci on the chromosome and at different locations in sequence space. First, I dissect chromosomal neighborhood effects that underlie locus-dependent differences in the potential of a gene under selection to become more highly expressed. Next, I find that the effects of point mutations in promoter sequences are dependent on sequence context, and that an existing energy matrix model performs poorly in predicting relative expression of unrelated sequences. Finally, I show that a substantial fraction of random sequences contain functional promoters and I present an extended thermodynamic model that predicts promoter strength in full sequence space. Taken together, these results provide new insights and guides on how to integrate information on sequence context to improve our qualitative and quantitative understanding of bacterial gene expression, with implications for rapid evolution of drug resistance, de novo evolution of genes, and horizontal gene transfer."}],"_id":"26","oa_version":"Published Version","alternative_title":["ISTA Thesis"],"publisher":"Institute of Science and Technology Austria","pubrep_id":"1059","ddc":["576","579"],"language":[{"iso":"eng"}],"oa":1,"page":"109","publication_identifier":{"issn":["2663-337X"]},"file":[{"relation":"source_file","checksum":"413cbce1cd1debeae3abe2a25dbc70d1","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","access_level":"closed","date_created":"2019-02-08T10:51:22Z","date_updated":"2020-07-14T12:45:43Z","file_name":"Thesis_Steinrueck_final.docx","file_size":9190845,"creator":"dernst","file_id":"5941","embargo_to":"open_access"},{"file_name":"Thesis_Steinrueck_final.pdf","date_updated":"2021-02-11T11:17:14Z","file_size":7521973,"file_id":"5942","creator":"dernst","relation":"main_file","checksum":"3def8b7854c8b42d643597ce0215efac","embargo":"2019-11-02","access_level":"open_access","date_created":"2019-02-08T10:51:22Z","content_type":"application/pdf"}],"type":"dissertation","citation":{"chicago":"Steinrück, Magdalena. “The Influence of Sequence Context on the Evolution of Bacterial Gene Expression.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th1059\">https://doi.org/10.15479/AT:ISTA:th1059</a>.","apa":"Steinrück, M. (2018). <i>The influence of sequence context on the evolution of bacterial gene expression</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th1059\">https://doi.org/10.15479/AT:ISTA:th1059</a>","mla":"Steinrück, Magdalena. <i>The Influence of Sequence Context on the Evolution of Bacterial Gene Expression</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th1059\">10.15479/AT:ISTA:th1059</a>.","ista":"Steinrück M. 2018. The influence of sequence context on the evolution of bacterial gene expression. Institute of Science and Technology Austria.","short":"M. Steinrück, The Influence of Sequence Context on the Evolution of Bacterial Gene Expression, Institute of Science and Technology Austria, 2018.","ieee":"M. Steinrück, “The influence of sequence context on the evolution of bacterial gene expression,” Institute of Science and Technology Austria, 2018.","ama":"Steinrück M. The influence of sequence context on the evolution of bacterial gene expression. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th1059\">10.15479/AT:ISTA:th1059</a>"},"author":[{"last_name":"Steinrück","orcid":"0000-0003-1229-9719","full_name":"Steinrück, Magdalena","id":"2C023F40-F248-11E8-B48F-1D18A9856A87","first_name":"Magdalena"}],"file_date_updated":"2021-02-11T11:17:14Z"},{"author":[{"id":"475990FE-F248-11E8-B48F-1D18A9856A87","full_name":"Contreras, Ximena","first_name":"Ximena","last_name":"Contreras"},{"last_name":"Hippenmeyer","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","first_name":"Simon"}],"citation":{"mla":"Contreras, Ximena, and Simon Hippenmeyer. “Incorrect Trafficking Route Leads to Autism.” <i>Brain a Journal of Neurology</i>, vol. 141, no. 9, Oxford University Press, 2018, pp. 2542–44, doi:<a href=\"https://doi.org/10.1093/brain/awy218\">10.1093/brain/awy218</a>.","ista":"Contreras X, Hippenmeyer S. 2018. Incorrect trafficking route leads to autism. Brain a journal of neurology. 141(9), 2542–2544.","apa":"Contreras, X., &#38; Hippenmeyer, S. (2018). Incorrect trafficking route leads to autism. <i>Brain a Journal of Neurology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/brain/awy218\">https://doi.org/10.1093/brain/awy218</a>","chicago":"Contreras, Ximena, and Simon Hippenmeyer. “Incorrect Trafficking Route Leads to Autism.” <i>Brain a Journal of Neurology</i>. Oxford University Press, 2018. <a href=\"https://doi.org/10.1093/brain/awy218\">https://doi.org/10.1093/brain/awy218</a>.","ieee":"X. Contreras and S. Hippenmeyer, “Incorrect trafficking route leads to autism,” <i>Brain a journal of neurology</i>, vol. 141, no. 9. Oxford University Press, pp. 2542–2544, 2018.","ama":"Contreras X, Hippenmeyer S. Incorrect trafficking route leads to autism. <i>Brain a journal of neurology</i>. 2018;141(9):2542-2544. doi:<a href=\"https://doi.org/10.1093/brain/awy218\">10.1093/brain/awy218</a>","short":"X. Contreras, S. Hippenmeyer, Brain a Journal of Neurology 141 (2018) 2542–2544."},"issue":"9","type":"journal_article","volume":141,"page":"2542 - 2544","language":[{"iso":"eng"}],"publisher":"Oxford University Press","external_id":{"isi":["000446548100012"]},"oa_version":"None","_id":"28","abstract":[{"text":"This scientific commentary refers to ‘NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice’ by Szczurkowska et al. ","lang":"eng"}],"department":[{"_id":"SiHi"}],"isi":1,"status":"public","day":"01","month":"09","related_material":{"record":[{"relation":"part_of_dissertation","id":"7902","status":"public"}]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","title":"Incorrect trafficking route leads to autism","date_created":"2018-12-11T11:44:14Z","publication_status":"published","year":"2018","scopus_import":"1","article_processing_charge":"No","doi":"10.1093/brain/awy218","fulldoi":"https://doi.org/10.1093/brain/awy218","date_published":"2018-09-01T00:00:00Z","publication":"Brain a journal of neurology","quality_controlled":"1","date_updated":"2026-10-04T22:30:22Z","intvolume":"       141"},{"abstract":[{"lang":"eng","text":"Although much is known about the physiological framework of T cell motility, and numerous rate-limiting molecules have been identified through loss-of-function approaches, an integrated functional concept of T cell motility is lacking. Here, we used in vivo precision morphometry together with analysis of cytoskeletal dynamics in vitro to deconstruct the basic mechanisms of T cell migration within lymphatic organs. We show that the contributions of the integrin LFA-1 and the chemokine receptor CCR7 are complementary rather than positioned in a linear pathway, as they are during leukocyte extravasation from the blood vasculature. Our data demonstrate that CCR7 controls cortical actin flows, whereas integrins mediate substrate friction that is sufficient to drive locomotion in the absence of considerable surface adhesions and plasma membrane flux."}],"_id":"15","ec_funded":1,"oa_version":"Published Version","project":[{"grant_number":"724373","_id":"25FE9508-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Cellular Navigation Along Spatial Gradients"},{"call_identifier":"H2020","name":"Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells","grant_number":"747687","_id":"260AA4E2-B435-11E9-9278-68D0E5697425"},{"name":"Molecular and system level view of immune cell migration","_id":"25A48D24-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 1396-2014"},{"name":"Cytoskeletal force generation and force transduction of migrating leukocytes","call_identifier":"FP7","_id":"25A603A2-B435-11E9-9278-68D0E5697425","grant_number":"281556"}],"department":[{"_id":"MiSi"},{"_id":"Bio"}],"external_id":{"pmid":["29777221"],"isi":["000433041500026"]},"title":"Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"relation":"dissertation_contains","id":"6891","status":"public"}]},"day":"18","month":"05","status":"public","isi":1,"article_processing_charge":"No","scopus_import":"1","fulldoi":"https://doi.org/10.1038/s41590-018-0109-z","doi":"10.1038/s41590-018-0109-z","publication_status":"published","date_created":"2018-12-11T11:44:10Z","year":"2018","date_updated":"2026-10-04T22:30:26Z","quality_controlled":"1","publist_id":"8040","intvolume":"        19","date_published":"2018-05-18T00:00:00Z","publication":"Nature Immunology","pmid":1,"author":[{"last_name":"Hons","first_name":"Miroslav","id":"4167FE56-F248-11E8-B48F-1D18A9856A87","full_name":"Hons, Miroslav","orcid":"0000-0002-6625-3348"},{"last_name":"Kopf","first_name":"Aglaja","full_name":"Kopf, Aglaja","orcid":"0000-0002-2187-6656","id":"31DAC7B6-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hauschild","full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"},{"last_name":"Leithner","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87","full_name":"Leithner, Alexander F","orcid":"0000-0002-1073-744X","first_name":"Alexander F"},{"last_name":"Gärtner","first_name":"Florian R","id":"397A88EE-F248-11E8-B48F-1D18A9856A87","full_name":"Gärtner, Florian R","orcid":"0000-0001-6120-3723"},{"first_name":"Jun","full_name":"Abe, Jun","last_name":"Abe"},{"last_name":"Renkawitz","first_name":"Jörg","id":"3F0587C8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2856-3369","full_name":"Renkawitz, Jörg"},{"last_name":"Stein","full_name":"Stein, Jens","first_name":"Jens"},{"last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"citation":{"chicago":"Hons, Miroslav, Aglaja Kopf, Robert Hauschild, Alexander F Leithner, Florian R Gärtner, Jun Abe, Jörg Renkawitz, Jens Stein, and Michael K Sixt. “Chemokines and Integrins Independently Tune Actin Flow and Substrate Friction during Intranodal Migration of T Cells.” <i>Nature Immunology</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41590-018-0109-z\">https://doi.org/10.1038/s41590-018-0109-z</a>.","apa":"Hons, M., Kopf, A., Hauschild, R., Leithner, A. F., Gärtner, F. R., Abe, J., … Sixt, M. K. (2018). Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. <i>Nature Immunology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41590-018-0109-z\">https://doi.org/10.1038/s41590-018-0109-z</a>","mla":"Hons, Miroslav, et al. “Chemokines and Integrins Independently Tune Actin Flow and Substrate Friction during Intranodal Migration of T Cells.” <i>Nature Immunology</i>, vol. 19, no. 6, Nature Publishing Group, 2018, pp. 606–16, doi:<a href=\"https://doi.org/10.1038/s41590-018-0109-z\">10.1038/s41590-018-0109-z</a>.","ista":"Hons M, Kopf A, Hauschild R, Leithner AF, Gärtner FR, Abe J, Renkawitz J, Stein J, Sixt MK. 2018. Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. Nature Immunology. 19(6), 606–616.","short":"M. Hons, A. Kopf, R. Hauschild, A.F. Leithner, F.R. Gärtner, J. Abe, J. Renkawitz, J. Stein, M.K. Sixt, Nature Immunology 19 (2018) 606–616.","ama":"Hons M, Kopf A, Hauschild R, et al. Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. <i>Nature Immunology</i>. 2018;19(6):606-616. doi:<a href=\"https://doi.org/10.1038/s41590-018-0109-z\">10.1038/s41590-018-0109-z</a>","ieee":"M. Hons <i>et al.</i>, “Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells,” <i>Nature Immunology</i>, vol. 19, no. 6. Nature Publishing Group, pp. 606–616, 2018."},"acknowledged_ssus":[{"_id":"SSU"}],"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pubmed/29777221","open_access":"1"}],"type":"journal_article","issue":"6","volume":19,"acknowledgement":"This work was funded by grants from the European Research Council (ERC StG 281556 and CoG 724373) and the Austrian Science Foundation (FWF) to M.S. and by Swiss National Foundation (SNF) project grants 31003A_135649, 31003A_153457 and CR23I3_156234 to J.V.S. F.G. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 747687, and J.R. was funded by an EMBO long-term fellowship (ALTF 1396-2014).","ddc":["570"],"publisher":"Nature Publishing Group","page":"606 - 616","oa":1,"language":[{"iso":"eng"}]},{"fulldoi":"https://doi.org/10.1007/s10494-018-9896-4","doi":"10.1007/s10494-018-9896-4","scopus_import":"1","article_processing_charge":"Yes (via OA deal)","year":"2018","date_created":"2018-12-11T11:46:23Z","publication_status":"published","publist_id":"7401","intvolume":"       100","quality_controlled":"1","date_updated":"2026-10-04T22:30:31Z","publication":"Flow Turbulence and Combustion","date_published":"2018-01-01T00:00:00Z","department":[{"_id":"BjHo"}],"project":[{"_id":"25152F3A-B435-11E9-9278-68D0E5697425","grant_number":"306589","name":"Decoding the complexity of turbulence at its origin","call_identifier":"FP7"}],"_id":"422","abstract":[{"text":"We show that a rather simple, steady modification of the streamwise velocity profile in a pipe can lead to a complete collapse of turbulence and the flow fully relaminarizes. Two different devices, a stationary obstacle (inset) and a device which injects fluid through an annular gap close to the wall, are used to control the flow. Both devices modify the streamwise velocity profile such that the flow in the center of the pipe is decelerated and the flow in the near wall region is accelerated. We present measurements with stereoscopic particle image velocimetry to investigate and capture the development of the relaminarizing flow downstream these devices and the specific circumstances responsible for relaminarization. We find total relaminarization up to Reynolds numbers of 6000, where the skin friction in the far downstream distance is reduced by a factor of 3.4 due to relaminarization. In a smooth straight pipe the flow remains completely laminar downstream of the control. Furthermore, we show that transient (temporary) relaminarization in a spatially confined region right downstream the devices occurs also at much higher Reynolds numbers, accompanied by a significant local skin friction drag reduction. The underlying physical mechanism of relaminarization is attributed to a weakening of the near-wall turbulence production cycle.","lang":"eng"}],"ec_funded":1,"oa_version":"Published Version","external_id":{"isi":["000433113900004"]},"title":"Relaminarization by steady modification of the streamwise velocity profile in a pipe","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","has_accepted_license":"1","day":"01","related_material":{"record":[{"relation":"dissertation_contains","id":"7258","status":"public"}]},"month":"01","isi":1,"status":"public","corr_author":"1","volume":100,"file":[{"file_id":"5717","creator":"dernst","file_size":2210020,"file_name":"2018_FlowTurbulenceCombust_Kuehnen.pdf","date_updated":"2020-07-14T12:46:25Z","content_type":"application/pdf","date_created":"2018-12-17T15:52:37Z","access_level":"open_access","checksum":"d7c0bade150faabca150b0a9986e60ca","relation":"main_file"}],"publisher":"Springer","ddc":["530"],"oa":1,"language":[{"iso":"eng"}],"page":"919 - 942","citation":{"apa":"Kühnen, J., Scarselli, D., Schaner, M., &#38; Hof, B. (2018). Relaminarization by steady modification of the streamwise velocity profile in a pipe. <i>Flow Turbulence and Combustion</i>. Springer. <a href=\"https://doi.org/10.1007/s10494-018-9896-4\">https://doi.org/10.1007/s10494-018-9896-4</a>","ista":"Kühnen J, Scarselli D, Schaner M, Hof B. 2018. Relaminarization by steady modification of the streamwise velocity profile in a pipe. Flow Turbulence and Combustion. 100(4), 919–942.","mla":"Kühnen, Jakob, et al. “Relaminarization by Steady Modification of the Streamwise Velocity Profile in a Pipe.” <i>Flow Turbulence and Combustion</i>, vol. 100, no. 4, Springer, 2018, pp. 919–42, doi:<a href=\"https://doi.org/10.1007/s10494-018-9896-4\">10.1007/s10494-018-9896-4</a>.","chicago":"Kühnen, Jakob, Davide Scarselli, Markus Schaner, and Björn Hof. “Relaminarization by Steady Modification of the Streamwise Velocity Profile in a Pipe.” <i>Flow Turbulence and Combustion</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s10494-018-9896-4\">https://doi.org/10.1007/s10494-018-9896-4</a>.","ieee":"J. Kühnen, D. Scarselli, M. Schaner, and B. Hof, “Relaminarization by steady modification of the streamwise velocity profile in a pipe,” <i>Flow Turbulence and Combustion</i>, vol. 100, no. 4. Springer, pp. 919–942, 2018.","ama":"Kühnen J, Scarselli D, Schaner M, Hof B. Relaminarization by steady modification of the streamwise velocity profile in a pipe. <i>Flow Turbulence and Combustion</i>. 2018;100(4):919-942. doi:<a href=\"https://doi.org/10.1007/s10494-018-9896-4\">10.1007/s10494-018-9896-4</a>","short":"J. Kühnen, D. Scarselli, M. Schaner, B. Hof, Flow Turbulence and Combustion 100 (2018) 919–942."},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"author":[{"id":"3A47AE32-F248-11E8-B48F-1D18A9856A87","full_name":"Kühnen, Jakob","orcid":"0000-0003-4312-0179","first_name":"Jakob","last_name":"Kühnen"},{"id":"40315C30-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5227-4271","full_name":"Scarselli, Davide","first_name":"Davide","last_name":"Scarselli"},{"last_name":"Schaner","full_name":"Schaner, Markus","id":"316CE034-F248-11E8-B48F-1D18A9856A87","first_name":"Markus"},{"last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","orcid":"0000-0003-2057-2754","first_name":"Björn"}],"file_date_updated":"2020-07-14T12:46:25Z","type":"journal_article","issue":"4"},{"publication":"Nature Physics","date_published":"2018-01-08T00:00:00Z","intvolume":"        14","publist_id":"7360","quality_controlled":"1","date_updated":"2026-10-04T22:30:31Z","year":"2018","date_created":"2018-12-11T11:46:36Z","publication_status":"published","doi":"10.1038/s41567-017-0018-3","fulldoi":"https://doi.org/10.1038/s41567-017-0018-3","scopus_import":"1","article_processing_charge":"No","status":"public","isi":1,"related_material":{"record":[{"id":"12726","relation":"dissertation_contains","status":"public"},{"id":"14530","relation":"dissertation_contains","status":"public"},{"id":"7258","relation":"dissertation_contains","status":"public"}]},"month":"01","day":"08","corr_author":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Destabilizing turbulence in pipe flow","external_id":{"isi":["000429434100020"],"arxiv":["1711.06543"]},"project":[{"grant_number":"306589","_id":"25152F3A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Decoding the complexity of turbulence at its origin"},{"_id":"25104D44-B435-11E9-9278-68D0E5697425","grant_number":"737549","name":"Eliminating turbulence in oil pipelines","call_identifier":"H2020"}],"department":[{"_id":"BjHo"}],"oa_version":"Preprint","_id":"461","ec_funded":1,"abstract":[{"lang":"eng","text":"Turbulence is the major cause of friction losses in transport processes and it is responsible for a drastic drag increase in flows over bounding surfaces. While much effort is invested into developing ways to control and reduce turbulence intensities, so far no methods exist to altogether eliminate turbulence if velocities are sufficiently large. We demonstrate for pipe flow that appropriate distortions to the velocity profile lead to a complete collapse of turbulence and subsequently friction losses are reduced by as much as 90%. Counterintuitively, the return to laminar motion is accomplished by initially increasing turbulence intensities or by transiently amplifying wall shear. Since neither the Reynolds number nor the shear stresses decrease (the latter often increase), these measures are not indicative of turbulence collapse. Instead, an amplification mechanism                      measuring the interaction between eddies and the mean shear is found to set a threshold below which turbulence is suppressed beyond recovery."}],"language":[{"iso":"eng"}],"oa":1,"arxiv":1,"page":"386-390","publisher":"Nature Publishing Group","acknowledgement":"We acknowledge the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement 306589, the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 737549) and the Deutsche Forschungsgemeinschaft (Project No. FOR 1182) for financial support. We thank our technician P. Maier for providing highly valuable ideas and greatly supporting us in all technical aspects. We thank M. Schaner for technical drawings, construction and design. We thank M. Schwegel for a Matlab code to post-process experimental data.","volume":14,"type":"journal_article","main_file_link":[{"url":"https://arxiv.org/abs/1711.06543","open_access":"1"}],"citation":{"apa":"Kühnen, J., Song, B., Scarselli, D., Budanur, N. B., Riedl, M., Willis, A., … Hof, B. (2018). Destabilizing turbulence in pipe flow. <i>Nature Physics</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41567-017-0018-3\">https://doi.org/10.1038/s41567-017-0018-3</a>","mla":"Kühnen, Jakob, et al. “Destabilizing Turbulence in Pipe Flow.” <i>Nature Physics</i>, vol. 14, Nature Publishing Group, 2018, pp. 386–90, doi:<a href=\"https://doi.org/10.1038/s41567-017-0018-3\">10.1038/s41567-017-0018-3</a>.","ista":"Kühnen J, Song B, Scarselli D, Budanur NB, Riedl M, Willis A, Avila M, Hof B. 2018. Destabilizing turbulence in pipe flow. Nature Physics. 14, 386–390.","chicago":"Kühnen, Jakob, Baofang Song, Davide Scarselli, Nazmi B Budanur, Michael Riedl, Ashley Willis, Marc Avila, and Björn Hof. “Destabilizing Turbulence in Pipe Flow.” <i>Nature Physics</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41567-017-0018-3\">https://doi.org/10.1038/s41567-017-0018-3</a>.","ieee":"J. Kühnen <i>et al.</i>, “Destabilizing turbulence in pipe flow,” <i>Nature Physics</i>, vol. 14. Nature Publishing Group, pp. 386–390, 2018.","ama":"Kühnen J, Song B, Scarselli D, et al. Destabilizing turbulence in pipe flow. <i>Nature Physics</i>. 2018;14:386-390. doi:<a href=\"https://doi.org/10.1038/s41567-017-0018-3\">10.1038/s41567-017-0018-3</a>","short":"J. Kühnen, B. Song, D. Scarselli, N.B. Budanur, M. Riedl, A. Willis, M. Avila, B. Hof, Nature Physics 14 (2018) 386–390."},"author":[{"full_name":"Kühnen, Jakob","orcid":"0000-0003-4312-0179","id":"3A47AE32-F248-11E8-B48F-1D18A9856A87","first_name":"Jakob","last_name":"Kühnen"},{"first_name":"Baofang","full_name":"Song, Baofang","last_name":"Song"},{"last_name":"Scarselli","id":"40315C30-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5227-4271","full_name":"Scarselli, Davide","first_name":"Davide"},{"last_name":"Budanur","first_name":"Nazmi B","id":"3EA1010E-F248-11E8-B48F-1D18A9856A87","full_name":"Budanur, Nazmi B","orcid":"0000-0003-0423-5010"},{"last_name":"Riedl","first_name":"Michael","id":"3BE60946-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4844-6311","full_name":"Riedl, Michael"},{"full_name":"Willis, Ashley","first_name":"Ashley","last_name":"Willis"},{"last_name":"Avila","full_name":"Avila, Marc","first_name":"Marc"},{"first_name":"Björn","orcid":"0000-0003-2057-2754","full_name":"Hof, Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","last_name":"Hof"}]},{"isi":1,"status":"public","month":"04","related_material":{"record":[{"id":"6269","relation":"dissertation_contains","status":"public"}]},"day":"09","corr_author":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","title":"A functional study of AUXILIN LIKE1 and 2 two putative clathrin uncoating factors in Arabidopsis","has_accepted_license":"1","external_id":{"isi":["000429441400018"],"pmid":["29511054"]},"department":[{"_id":"JiFr"}],"project":[{"call_identifier":"FP7","name":"Polarity and subcellular dynamics in plants","grant_number":"282300","_id":"25716A02-B435-11E9-9278-68D0E5697425"}],"oa_version":"Published Version","abstract":[{"text":"Clathrin-mediated endocytosis (CME) is a cellular trafficking process in which cargoes and lipids are internalized from the plasma membrane into vesicles coated with clathrin and adaptor proteins. CME is essential for many developmental and physiological processes in plants, but its underlying mechanism is not well characterised compared to that in yeast and animal systems. Here, we searched for new factors involved in CME in Arabidopsis thaliana by performing Tandem Affinity Purification of proteins that interact with clathrin light chain, a principal component of the clathrin coat. Among the confirmed interactors, we found two putative homologues of the clathrin-coat uncoating factor auxilin previously described in non-plant systems. Overexpression of AUXILIN-LIKE1 and AUXILIN-LIKE2 in A. thaliana caused an arrest of seedling growth and development. This was concomitant with inhibited endocytosis due to blocking of clathrin recruitment after the initial step of adaptor protein binding to the plasma membrane. By contrast, auxilin-like(1/2) loss-of-function lines did not present endocytosis-related developmental or cellular phenotypes under normal growth conditions. This work contributes to the on-going characterization of the endocytotic machinery in plants and provides a robust tool for conditionally and specifically interfering with CME in A. thaliana.","lang":"eng"}],"_id":"412","ec_funded":1,"pmid":1,"publication":"The Plant Cell","date_published":"2018-04-09T00:00:00Z","intvolume":"        30","publist_id":"7417","date_updated":"2026-10-04T22:30:38Z","quality_controlled":"1","year":"2018","article_type":"original","publication_status":"published","date_created":"2018-12-11T11:46:20Z","doi":"10.1105/tpc.17.00785","fulldoi":"https://doi.org/10.1105/tpc.17.00785","article_processing_charge":"No","scopus_import":"1","type":"journal_article","issue":"3","citation":{"apa":"Adamowski, M., Narasimhan, M., Kania, U., Glanc, M., De Jaeger, G., &#38; Friml, J. (2018). A functional study of AUXILIN LIKE1 and 2 two putative clathrin uncoating factors in Arabidopsis. <i>The Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.17.00785\">https://doi.org/10.1105/tpc.17.00785</a>","mla":"Adamowski, Maciek, et al. “A Functional Study of AUXILIN LIKE1 and 2 Two Putative Clathrin Uncoating Factors in Arabidopsis.” <i>The Plant Cell</i>, vol. 30, no. 3, American Society of Plant Biologists, 2018, pp. 700–16, doi:<a href=\"https://doi.org/10.1105/tpc.17.00785\">10.1105/tpc.17.00785</a>.","ista":"Adamowski M, Narasimhan M, Kania U, Glanc M, De Jaeger G, Friml J. 2018. A functional study of AUXILIN LIKE1 and 2 two putative clathrin uncoating factors in Arabidopsis. The Plant Cell. 30(3), 700–716.","chicago":"Adamowski, Maciek, Madhumitha Narasimhan, Urszula Kania, Matous Glanc, Geert De Jaeger, and Jiří Friml. “A Functional Study of AUXILIN LIKE1 and 2 Two Putative Clathrin Uncoating Factors in Arabidopsis.” <i>The Plant Cell</i>. American Society of Plant Biologists, 2018. <a href=\"https://doi.org/10.1105/tpc.17.00785\">https://doi.org/10.1105/tpc.17.00785</a>.","ieee":"M. Adamowski, M. Narasimhan, U. Kania, M. Glanc, G. De Jaeger, and J. Friml, “A functional study of AUXILIN LIKE1 and 2 two putative clathrin uncoating factors in Arabidopsis,” <i>The Plant Cell</i>, vol. 30, no. 3. American Society of Plant Biologists, pp. 700–716, 2018.","ama":"Adamowski M, Narasimhan M, Kania U, Glanc M, De Jaeger G, Friml J. A functional study of AUXILIN LIKE1 and 2 two putative clathrin uncoating factors in Arabidopsis. <i>The Plant Cell</i>. 2018;30(3):700-716. doi:<a href=\"https://doi.org/10.1105/tpc.17.00785\">10.1105/tpc.17.00785</a>","short":"M. Adamowski, M. Narasimhan, U. Kania, M. Glanc, G. De Jaeger, J. Friml, The Plant Cell 30 (2018) 700–716."},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2022-05-23T09:12:38Z","author":[{"last_name":"Adamowski","first_name":"Maciek","id":"45F536D2-F248-11E8-B48F-1D18A9856A87","full_name":"Adamowski, Maciek","orcid":"0000-0001-6463-5257"},{"id":"44BF24D0-F248-11E8-B48F-1D18A9856A87","full_name":"Narasimhan, Madhumitha","orcid":"0000-0002-8600-0671","first_name":"Madhumitha","last_name":"Narasimhan"},{"last_name":"Kania","full_name":"Kania, Urszula","id":"4AE5C486-F248-11E8-B48F-1D18A9856A87","first_name":"Urszula"},{"id":"1AE1EA24-02D0-11E9-9BAA-DAF4881429F2","full_name":"Glanc, Matous","orcid":"0000-0003-0619-7783","first_name":"Matous","last_name":"Glanc"},{"first_name":"Geert","full_name":"De Jaeger, Geert","last_name":"De Jaeger"},{"first_name":"Jirí","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"}],"language":[{"iso":"eng"}],"oa":1,"page":"700 - 716","publisher":"American Society of Plant Biologists","ddc":["580"],"acknowledgement":"We thank James Matthew Watson, Monika Borowska, and Peggy Stolt-Bergner at ProTech Facility of the Vienna Biocenter Core Facilities for the CRISPR/CAS9 construct; Anna Müller for assistance with molecular cloning; Sebastian Bednarek, Liwen Jiang, and Daniël Van Damme for sharing published material; Matyáš Fendrych, Daniël Van Damme, and Lindy Abas for valuable discussions; and Martine De Cock for help with correcting the manuscript. This work was supported by the European Research Council under the European Union Seventh Framework Programme (FP7/2007-2013)/ERC Grant 282300 and by the Ministry of Education of the Czech Republic/MŠMT project NPUI-LO1417.","file":[{"access_level":"open_access","content_type":"application/pdf","date_created":"2022-05-23T09:12:38Z","relation":"main_file","checksum":"4e165e653b67d3f0684697f21aace5a1","success":1,"creator":"dernst","file_id":"11406","file_name":"2018_PlantCell_Adamowski.pdf","date_updated":"2022-05-23T09:12:38Z","file_size":4407538}],"publication_identifier":{"eissn":["1532-298X"],"issn":["1040-4651"]},"volume":30},{"department":[{"_id":"JoCs"}],"abstract":[{"lang":"eng","text":"The hippocampus is a key brain region for spatial memory and navigation and is needed at all stages of memory, including encoding, consolidation, and recall. Hippocampal place cells selectively discharge at specific locations of the environment to form a cognitive map of the space. During the rest period and sleep following spatial navigation and/or learning, the waking activity of the place cells is reactivated within high synchrony events. This reactivation is thought to be important for memory consolidation and stabilization of the spatial representations. The aim of my thesis was to directly test whether the reactivation content encoded in firing patterns of place cells is important for consolidation of spatial memories. In particular, I aimed to test whether, in cases when multiple spatial memory traces are acquired during learning, the specific disruption of the reactivation of a subset of these memories leads to the selective disruption of the corresponding memory traces or through memory interference the other learned memories are disrupted as well. In this thesis, using a modified cheeseboard paradigm and a closed-loop recording setup with feedback optogenetic stimulation, I examined how the disruption of the reactivation of specific spiking patterns affects consolidation of the corresponding memory traces. To obtain multiple distinctive memories, animals had to perform a spatial task in two distinct cheeseboard environments and the reactivation of spiking patterns associated with one of the environments (target) was disrupted after learning during four hours rest period using a real-time decoding method. This real-time decoding method was capable of selectively affecting the firing rates and cofiring correlations of the target environment-encoding cells. The selective disruption led to behavioural impairment in the memory tests after the rest periods in the target environment but not in the other undisrupted control environment. In addition, the map of the target environment was less stable in the impaired memory tests compared to the learning session before than the map of the control environment. However, when the animal relearned the task, the same map recurred in the target environment that was present during learning before the disruption. Altogether my work demonstrated that the reactivation content is important: assembly-related disruption of reactivation can lead to a selective memory impairment and deficiency in map stability. These findings indeed suggest that reactivated assembly patterns reflect processes associated with the consolidation of memory traces. "}],"_id":"48","oa_version":"Published Version","alternative_title":["ISTA Thesis"],"title":"Reactivation content is important for consolidation of spatial memory","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","has_accepted_license":"1","degree_awarded":"PhD","day":"27","month":"08","status":"public","corr_author":"1","fulldoi":"https://doi.org/10.15479/AT:ISTA:th_1042","doi":"10.15479/AT:ISTA:th_1042","supervisor":[{"last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L"}],"article_processing_charge":"No","year":"2018","publication_status":"published","date_created":"2018-12-11T11:44:21Z","publist_id":"8006","date_updated":"2026-04-08T14:13:15Z","date_published":"2018-08-27T00:00:00Z","citation":{"short":"I. Gridchyn, Reactivation Content Is Important for Consolidation of Spatial Memory, Institute of Science and Technology Austria, 2018.","ama":"Gridchyn I. Reactivation content is important for consolidation of spatial memory. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">10.15479/AT:ISTA:th_1042</a>","ieee":"I. Gridchyn, “Reactivation content is important for consolidation of spatial memory,” Institute of Science and Technology Austria, 2018.","chicago":"Gridchyn, Igor. “Reactivation Content Is Important for Consolidation of Spatial Memory.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">https://doi.org/10.15479/AT:ISTA:th_1042</a>.","mla":"Gridchyn, Igor. <i>Reactivation Content Is Important for Consolidation of Spatial Memory</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">10.15479/AT:ISTA:th_1042</a>.","ista":"Gridchyn I. 2018. Reactivation content is important for consolidation of spatial memory. Institute of Science and Technology Austria.","apa":"Gridchyn, I. (2018). <i>Reactivation content is important for consolidation of spatial memory</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">https://doi.org/10.15479/AT:ISTA:th_1042</a>"},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"author":[{"first_name":"Igor","id":"4B60654C-F248-11E8-B48F-1D18A9856A87","full_name":"Gridchyn, Igor","orcid":"0000-0002-1807-1929","last_name":"Gridchyn"}],"file_date_updated":"2021-02-11T23:30:22Z","type":"dissertation","publication_identifier":{"issn":["2663-337X"]},"file":[{"date_created":"2019-04-08T13:36:01Z","access_level":"closed","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","checksum":"7db4415e435590fa33542c7b0a0321d7","relation":"source_file","embargo_to":"open_access","creator":"dernst","file_id":"6236","file_size":7666687,"file_name":"2018_Thesis_Gridchyn_source.docx","date_updated":"2021-02-11T23:30:22Z"},{"file_size":6034153,"date_updated":"2021-02-11T11:17:18Z","file_name":"2018_Thesis_Gridchyn.pdf","file_id":"6237","creator":"dernst","embargo":"2019-08-29","checksum":"f96f3fe8979f7b1e6db6acaca962b10c","relation":"main_file","access_level":"open_access","date_created":"2019-04-08T13:36:01Z","content_type":"application/pdf"}],"pubrep_id":"1042","publisher":"Institute of Science and Technology Austria","ddc":["573"],"oa":1,"language":[{"iso":"eng"}],"page":"104"},{"isi":1,"status":"public","related_material":{"record":[{"status":"public","id":"5585","relation":"popular_science"},{"status":"public","relation":"dissertation_contains","id":"6371"}]},"month":"09","day":"10","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","title":"Evolutionary potential of transcription factors for gene regulatory rewiring","has_accepted_license":"1","external_id":{"isi":["000447947600021"]},"department":[{"_id":"CaGu"},{"_id":"GaTk"},{"_id":"JoBo"}],"project":[{"call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"_id":"2578D616-B435-11E9-9278-68D0E5697425","grant_number":"648440","name":"Selective Barriers to Horizontal Gene Transfer","call_identifier":"H2020"},{"name":"Design principles underlying genetic switch architecture","grant_number":"24573","_id":"251EE76E-B435-11E9-9278-68D0E5697425"}],"oa_version":"Submitted Version","_id":"67","ec_funded":1,"abstract":[{"lang":"eng","text":"Gene regulatory networks evolve through rewiring of individual components—that is, through changes in regulatory connections. However, the mechanistic basis of regulatory rewiring is poorly understood. Using a canonical gene regulatory system, we quantify the properties of transcription factors that determine the evolutionary potential for rewiring of regulatory connections: robustness, tunability and evolvability. In vivo repression measurements of two repressors at mutated operator sites reveal their contrasting evolutionary potential: while robustness and evolvability were positively correlated, both were in trade-off with tunability. Epistatic interactions between adjacent operators alleviated this trade-off. A thermodynamic model explains how the differences in robustness, tunability and evolvability arise from biophysical characteristics of repressor–DNA binding. The model also uncovers that the energy matrix, which describes how mutations affect repressor–DNA binding, encodes crucial information about the evolutionary potential of a repressor. The biophysical determinants of evolutionary potential for regulatory rewiring constitute a mechanistic framework for understanding network evolution."}],"publication":"Nature Ecology and Evolution","date_published":"2018-09-10T00:00:00Z","intvolume":"         2","publist_id":"7987","date_updated":"2026-10-04T22:30:40Z","quality_controlled":"1","year":"2018","publication_status":"published","date_created":"2018-12-11T11:44:27Z","article_type":"original","doi":"10.1038/s41559-018-0651-y","fulldoi":"https://doi.org/10.1038/s41559-018-0651-y","scopus_import":"1","article_processing_charge":"No","issue":"10","type":"journal_article","citation":{"chicago":"Igler, Claudia, Mato Lagator, Gašper Tkačik, Jonathan P Bollback, and Calin C Guet. “Evolutionary Potential of Transcription Factors for Gene Regulatory Rewiring.” <i>Nature Ecology and Evolution</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41559-018-0651-y\">https://doi.org/10.1038/s41559-018-0651-y</a>.","apa":"Igler, C., Lagator, M., Tkačik, G., Bollback, J. P., &#38; Guet, C. C. (2018). Evolutionary potential of transcription factors for gene regulatory rewiring. <i>Nature Ecology and Evolution</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41559-018-0651-y\">https://doi.org/10.1038/s41559-018-0651-y</a>","ista":"Igler C, Lagator M, Tkačik G, Bollback JP, Guet CC. 2018. Evolutionary potential of transcription factors for gene regulatory rewiring. Nature Ecology and Evolution. 2(10), 1633–1643.","mla":"Igler, Claudia, et al. “Evolutionary Potential of Transcription Factors for Gene Regulatory Rewiring.” <i>Nature Ecology and Evolution</i>, vol. 2, no. 10, Nature Publishing Group, 2018, pp. 1633–43, doi:<a href=\"https://doi.org/10.1038/s41559-018-0651-y\">10.1038/s41559-018-0651-y</a>.","short":"C. Igler, M. Lagator, G. Tkačik, J.P. Bollback, C.C. Guet, Nature Ecology and Evolution 2 (2018) 1633–1643.","ama":"Igler C, Lagator M, Tkačik G, Bollback JP, Guet CC. Evolutionary potential of transcription factors for gene regulatory rewiring. <i>Nature Ecology and Evolution</i>. 2018;2(10):1633-1643. doi:<a href=\"https://doi.org/10.1038/s41559-018-0651-y\">10.1038/s41559-018-0651-y</a>","ieee":"C. Igler, M. Lagator, G. Tkačik, J. P. Bollback, and C. C. Guet, “Evolutionary potential of transcription factors for gene regulatory rewiring,” <i>Nature Ecology and Evolution</i>, vol. 2, no. 10. Nature Publishing Group, pp. 1633–1643, 2018."},"file_date_updated":"2020-07-14T12:47:37Z","author":[{"id":"46613666-F248-11E8-B48F-1D18A9856A87","full_name":"Igler, Claudia","orcid":"0000-0001-7777-546X","first_name":"Claudia","last_name":"Igler"},{"full_name":"Lagator, Mato","id":"345D25EC-F248-11E8-B48F-1D18A9856A87","first_name":"Mato","last_name":"Lagator"},{"last_name":"Tkacik","orcid":"0000-0002-6699-1455","full_name":"Tkacik, Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","first_name":"Gasper"},{"last_name":"Bollback","first_name":"Jonathan P","orcid":"0000-0002-4624-4612","full_name":"Bollback, Jonathan P","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Calin C","full_name":"Guet, Calin C","orcid":"0000-0001-6220-2052","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","last_name":"Guet"}],"oa":1,"language":[{"iso":"eng"}],"page":"1633 - 1643","publisher":"Nature Publishing Group","ddc":["570"],"file":[{"creator":"dernst","file_id":"7830","file_name":"2018_NatureEcology_Igler.pdf","date_updated":"2020-07-14T12:47:37Z","file_size":1135973,"content_type":"application/pdf","access_level":"open_access","date_created":"2020-05-14T11:28:52Z","relation":"main_file","checksum":"383a2e2c944a856e2e821ec8e7bf71b6"}],"volume":2}]