[{"keyword":["Multidisciplinary"],"date_updated":"2024-03-25T12:12:23Z","fulldoi":"https://doi.org/10.1073/pnas.1615310114","issue":"7","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","pmid":1,"doi":"10.1073/pnas.1615310114","main_file_link":[{"url":"https://doi.org/10.1073/pnas.1615310114","open_access":"1"}],"status":"public","citation":{"apa":"Michael, A. K., Fribourgh, J. L., Chelliah, Y., Sandate, C. R., Hura, G. L., Schneidman-Duhovny, D., … Partch, C. L. (2017). Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1. <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1615310114\">https://doi.org/10.1073/pnas.1615310114</a>","mla":"Michael, Alicia K., et al. “Formation of a Repressive Complex in the Mammalian Circadian Clock Is Mediated by the Secondary Pocket of CRY1.” <i>Proceedings of the National Academy of Sciences</i>, vol. 114, no. 7, Proceedings of the National Academy of Sciences, 2017, pp. 1560–65, doi:<a href=\"https://doi.org/10.1073/pnas.1615310114\">10.1073/pnas.1615310114</a>.","ieee":"A. K. Michael <i>et al.</i>, “Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1,” <i>Proceedings of the National Academy of Sciences</i>, vol. 114, no. 7. Proceedings of the National Academy of Sciences, pp. 1560–1565, 2017.","short":"A.K. Michael, J.L. Fribourgh, Y. Chelliah, C.R. Sandate, G.L. Hura, D. Schneidman-Duhovny, S.M. Tripathi, J.S. Takahashi, C.L. Partch, Proceedings of the National Academy of Sciences 114 (2017) 1560–1565.","ama":"Michael AK, Fribourgh JL, Chelliah Y, et al. Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1. <i>Proceedings of the National Academy of Sciences</i>. 2017;114(7):1560-1565. doi:<a href=\"https://doi.org/10.1073/pnas.1615310114\">10.1073/pnas.1615310114</a>","chicago":"Michael, Alicia K., Jennifer L. Fribourgh, Yogarany Chelliah, Colby R. Sandate, Greg L. Hura, Dina Schneidman-Duhovny, Sarvind M. Tripathi, Joseph S. Takahashi, and Carrie L. Partch. “Formation of a Repressive Complex in the Mammalian Circadian Clock Is Mediated by the Secondary Pocket of CRY1.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences, 2017. <a href=\"https://doi.org/10.1073/pnas.1615310114\">https://doi.org/10.1073/pnas.1615310114</a>.","ista":"Michael AK, Fribourgh JL, Chelliah Y, Sandate CR, Hura GL, Schneidman-Duhovny D, Tripathi SM, Takahashi JS, Partch CL. 2017. Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1. Proceedings of the National Academy of Sciences. 114(7), 1560–1565."},"date_published":"2017-01-31T00:00:00Z","external_id":{"pmid":["28143926"]},"type":"journal_article","oa_version":"Published Version","abstract":[{"lang":"eng","text":"The basic helix–loop–helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (brain and muscle Arnt-like protein 1) sits at the core of the mammalian circadian transcription/translation feedback loop. Precise control of CLOCK:BMAL1 activity by coactivators and repressors establishes the ∼24-h periodicity of gene expression. Formation of a repressive complex, defined by the core clock proteins cryptochrome 1 (CRY1):CLOCK:BMAL1, plays an important role controlling the switch from repression to activation each day. Here we show that CRY1 binds directly to the PAS domain core of CLOCK:BMAL1, driven primarily by interaction with the CLOCK PAS-B domain. Integrative modeling and solution X-ray scattering studies unambiguously position a key loop of the CLOCK PAS-B domain in the secondary pocket of CRY1, analogous to the antenna chromophore-binding pocket of photolyase. CRY1 docks onto the transcription factor alongside the PAS domains, extending above the DNA-binding bHLH domain. Single point mutations at the interface on either CRY1 or CLOCK disrupt formation of the ternary complex, highlighting the importance of this interface for direct regulation of CLOCK:BMAL1 activity by CRY1."}],"month":"01","day":"31","volume":114,"publication":"Proceedings of the National Academy of Sciences","intvolume":"       114","oa":1,"language":[{"iso":"eng"}],"year":"2017","_id":"15157","page":"1560-1565","date_created":"2024-03-21T07:56:50Z","extern":"1","article_type":"original","author":[{"last_name":"Michael","id":"6437c950-2a03-11ee-914d-d6476dd7b75c","full_name":"Michael, Alicia Kathleen","first_name":"Alicia Kathleen"},{"full_name":"Fribourgh, Jennifer L.","last_name":"Fribourgh","first_name":"Jennifer L."},{"full_name":"Chelliah, Yogarany","last_name":"Chelliah","first_name":"Yogarany"},{"first_name":"Colby R.","last_name":"Sandate","full_name":"Sandate, Colby R."},{"last_name":"Hura","full_name":"Hura, Greg L.","first_name":"Greg L."},{"first_name":"Dina","full_name":"Schneidman-Duhovny, Dina","last_name":"Schneidman-Duhovny"},{"first_name":"Sarvind M.","last_name":"Tripathi","full_name":"Tripathi, Sarvind M."},{"first_name":"Joseph S.","last_name":"Takahashi","full_name":"Takahashi, Joseph S."},{"first_name":"Carrie L.","full_name":"Partch, Carrie L.","last_name":"Partch"}],"quality_controlled":"1","title":"Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1","scopus_import":"1","publisher":"Proceedings of the National Academy of Sciences","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]}},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","issue":"1","fulldoi":"https://doi.org/10.1111/php.12677","date_updated":"2024-03-25T12:09:21Z","keyword":["Physical and Theoretical Chemistry","General Medicine","Biochemistry"],"article_processing_charge":"No","date_published":"2017-02-01T00:00:00Z","citation":{"short":"A.K. Michael, J.L. Fribourgh, R.N. Van Gelder, C.L. Partch, Photochemistry and Photobiology 93 (2017) 128–140.","ieee":"A. K. Michael, J. L. Fribourgh, R. N. Van Gelder, and C. L. Partch, “Animal cryptochromes: Divergent roles in light perception, circadian timekeeping and beyond,” <i>Photochemistry and Photobiology</i>, vol. 93, no. 1. Wiley, pp. 128–140, 2017.","ama":"Michael AK, Fribourgh JL, Van Gelder RN, Partch CL. Animal cryptochromes: Divergent roles in light perception, circadian timekeeping and beyond. <i>Photochemistry and Photobiology</i>. 2017;93(1):128-140. doi:<a href=\"https://doi.org/10.1111/php.12677\">10.1111/php.12677</a>","ista":"Michael AK, Fribourgh JL, Van Gelder RN, Partch CL. 2017. Animal cryptochromes: Divergent roles in light perception, circadian timekeeping and beyond. Photochemistry and Photobiology. 93(1), 128–140.","chicago":"Michael, Alicia K., Jennifer L. Fribourgh, Russell N. Van Gelder, and Carrie L. Partch. “Animal Cryptochromes: Divergent Roles in Light Perception, Circadian Timekeeping and Beyond.” <i>Photochemistry and Photobiology</i>. Wiley, 2017. <a href=\"https://doi.org/10.1111/php.12677\">https://doi.org/10.1111/php.12677</a>.","mla":"Michael, Alicia K., et al. “Animal Cryptochromes: Divergent Roles in Light Perception, Circadian Timekeeping and Beyond.” <i>Photochemistry and Photobiology</i>, vol. 93, no. 1, Wiley, 2017, pp. 128–40, doi:<a href=\"https://doi.org/10.1111/php.12677\">10.1111/php.12677</a>.","apa":"Michael, A. K., Fribourgh, J. L., Van Gelder, R. N., &#38; Partch, C. L. (2017). Animal cryptochromes: Divergent roles in light perception, circadian timekeeping and beyond. <i>Photochemistry and Photobiology</i>. Wiley. <a href=\"https://doi.org/10.1111/php.12677\">https://doi.org/10.1111/php.12677</a>"},"status":"public","main_file_link":[{"url":"https://doi.org/10.1111/php.12677","open_access":"1"}],"doi":"10.1111/php.12677","month":"02","abstract":[{"lang":"eng","text":"Cryptochromes are evolutionarily related to the light‐dependent DNA repair enzyme photolyase, serving as major regulators of circadian rhythms in insects and vertebrate animals. There are two types of cryptochromes in the animal kingdom: <jats:italic>Drosophila</jats:italic>‐like CRYs that act as nonvisual photopigments linking circadian rhythms to the environmental light/dark cycle, and vertebrate‐like CRYs that do not appear to sense light directly, but control the generation of circadian rhythms by acting as transcriptional repressors. Some animals have both types of CRYs, while others possess only one. Cryptochromes have two domains, the photolyase homology region (PHR) and an extended, intrinsically disordered C‐terminus. While all animal CRYs share a high degree of sequence and structural homology in their PHR domains, the C‐termini are divergent in both length and sequence identity. Recently, cryptochrome function has been shown to extend beyond its pivotal role in circadian clocks, participating in regulation of the DNA damage response, cancer progression and glucocorticoid signaling, as well as being implicated as possible magnetoreceptors. In this review, we provide a historical perspective on the discovery of animal cryptochromes, examine similarities and differences of the two types of animal cryptochromes and explore some of the divergent roles for this class of proteins."}],"oa_version":"Published Version","type":"journal_article","publication":"Photochemistry and Photobiology","volume":93,"day":"01","year":"2017","language":[{"iso":"eng"}],"oa":1,"intvolume":"        93","extern":"1","date_created":"2024-03-21T07:57:18Z","_id":"15158","page":"128-140","publication_identifier":{"issn":["0031-8655"],"eissn":["1751-1097"]},"publisher":"Wiley","scopus_import":"1","title":"Animal cryptochromes: Divergent roles in light perception, circadian timekeeping and beyond","quality_controlled":"1","article_type":"original","author":[{"full_name":"Michael, Alicia Kathleen","last_name":"Michael","id":"6437c950-2a03-11ee-914d-d6476dd7b75c","first_name":"Alicia Kathleen"},{"first_name":"Jennifer L.","full_name":"Fribourgh, Jennifer L.","last_name":"Fribourgh"},{"last_name":"Van Gelder","full_name":"Van Gelder, Russell N.","first_name":"Russell N."},{"full_name":"Partch, Carrie L.","last_name":"Partch","first_name":"Carrie L."}]},{"citation":{"short":"A. Obertas, I. Caiazzo, J. Heyl, H. Richer, J. Kalirai, P.-E. Tremblay, Monthly Notices of the Royal Astronomical Society 474 (2017) 677–682.","ieee":"A. Obertas, I. Caiazzo, J. Heyl, H. Richer, J. Kalirai, and P.-E. Tremblay, “The onset of convective coupling and freezing in the white dwarfs of 47 Tucanae,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 474, no. 1. Oxford University Press, pp. 677–682, 2017.","ista":"Obertas A, Caiazzo I, Heyl J, Richer H, Kalirai J, Tremblay P-E. 2017. The onset of convective coupling and freezing in the white dwarfs of 47 Tucanae. Monthly Notices of the Royal Astronomical Society. 474(1), 677–682.","chicago":"Obertas, Alysa, Ilaria Caiazzo, Jeremy Heyl, Harvey Richer, Jason Kalirai, and Pier-Emmanuel Tremblay. “The Onset of Convective Coupling and Freezing in the White Dwarfs of 47 Tucanae.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2017. <a href=\"https://doi.org/10.1093/mnras/stx2759\">https://doi.org/10.1093/mnras/stx2759</a>.","ama":"Obertas A, Caiazzo I, Heyl J, Richer H, Kalirai J, Tremblay P-E. The onset of convective coupling and freezing in the white dwarfs of 47 Tucanae. <i>Monthly Notices of the Royal Astronomical Society</i>. 2017;474(1):677-682. doi:<a href=\"https://doi.org/10.1093/mnras/stx2759\">10.1093/mnras/stx2759</a>","apa":"Obertas, A., Caiazzo, I., Heyl, J., Richer, H., Kalirai, J., &#38; Tremblay, P.-E. (2017). The onset of convective coupling and freezing in the white dwarfs of 47 Tucanae. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stx2759\">https://doi.org/10.1093/mnras/stx2759</a>","mla":"Obertas, Alysa, et al. “The Onset of Convective Coupling and Freezing in the White Dwarfs of 47 Tucanae.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 474, no. 1, Oxford University Press, 2017, pp. 677–82, doi:<a href=\"https://doi.org/10.1093/mnras/stx2759\">10.1093/mnras/stx2759</a>."},"date_published":"2017-10-24T00:00:00Z","doi":"10.1093/mnras/stx2759","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1709.08097"}],"status":"public","abstract":[{"lang":"eng","text":"Using images from the Hubble Space Telescope Advanced Camera for Surveys, we measure the rate of cooling of white dwarfs in the globular cluster 47 Tucanae and compare it to modelled cooling curves. We examine the effects of the outer convective envelope reaching the nearly isothermal degenerate core and the release of latent heat during core crystallization on the white dwarf cooling rates. For white dwarfs typical of 47 Tuc, the onset of these effects occur at similar times. The latent heat released during crystallization is a small heat source. In contrast, the heat reservoir of the degenerate core is substantially larger. When the convective envelope reaches the nearly isothermal interior of the white dwarf, the star becomes brighter than it would be in the absence of this effect. Our modelled cooling curves that include this convective coupling closely match the observed luminosity function of the white dwarfs in 47 Tuc."}],"month":"10","external_id":{"arxiv":["1709.08097"]},"type":"journal_article","oa_version":"Preprint","fulldoi":"https://doi.org/10.1093/mnras/stx2759","date_updated":"2024-04-08T07:04:10Z","issue":"1","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"article_processing_charge":"No","date_created":"2024-03-26T10:40:05Z","_id":"15239","page":"677-682","extern":"1","scopus_import":"1","publisher":"Oxford University Press","publication_identifier":{"issn":["0035-8711"],"eissn":["1365-2966"]},"author":[{"first_name":"Alysa","last_name":"Obertas","full_name":"Obertas, Alysa"},{"first_name":"Ilaria","orcid":"0000-0002-4770-5388","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","full_name":"Caiazzo, Ilaria","last_name":"Caiazzo"},{"first_name":"Jeremy","last_name":"Heyl","full_name":"Heyl, Jeremy"},{"first_name":"Harvey","last_name":"Richer","full_name":"Richer, Harvey"},{"first_name":"Jason","last_name":"Kalirai","full_name":"Kalirai, Jason"},{"full_name":"Tremblay, Pier-Emmanuel","last_name":"Tremblay","first_name":"Pier-Emmanuel"}],"article_type":"original","quality_controlled":"1","title":"The onset of convective coupling and freezing in the white dwarfs of 47 Tucanae","volume":474,"publication":"Monthly Notices of the Royal Astronomical Society","arxiv":1,"day":"24","language":[{"iso":"eng"}],"year":"2017","intvolume":"       474","oa":1},{"title":"Deep HST imaging in 47 Tucanae: A global dynamical model","quality_controlled":"1","author":[{"full_name":"Heyl, J.","last_name":"Heyl","first_name":"J."},{"orcid":"0000-0002-4770-5388","first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","last_name":"Caiazzo","full_name":"Caiazzo, Ilaria"},{"full_name":"Richer, H.","last_name":"Richer","first_name":"H."},{"full_name":"Anderson, J.","last_name":"Anderson","first_name":"J."},{"full_name":"Kalirai, J.","last_name":"Kalirai","first_name":"J."},{"full_name":"Parada, J.","last_name":"Parada","first_name":"J."}],"article_type":"original","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"publisher":"American Astronomical Society","scopus_import":"1","extern":"1","date_created":"2024-03-26T10:40:23Z","_id":"15240","oa":1,"intvolume":"       850","year":"2017","language":[{"iso":"eng"}],"arxiv":1,"day":"01","publication":"The Astrophysical Journal","volume":850,"oa_version":"Preprint","type":"journal_article","external_id":{"arxiv":["1710.10666"]},"month":"12","abstract":[{"lang":"eng","text":"Multi-epoch observations with the Advanced Camera Survey and WFC3 on the Hubble Space Telescope provide a unique and comprehensive probe of stellar dynamics within 47 Tucanae. We confront analytic models of the globular cluster with the observed stellar proper motions that probe along the main sequence from just above 0.8–0.1M⊙ as well as white dwarfs younger than 1 Gyr. One field lies just beyond the half-light radius where dynamical models (e.g., lowered Maxwellian distributions) make robust predictions for the stellar proper motions. The observed proper motions in this outer field show evidence for anisotropy in the velocity distribution as well as skewness; the latter is evidence of rotation. The measured velocity dispersions and surface brightness distributions agree in detail with a rotating anisotropic model of the stellar distribution function with mild dependence of the proper-motion dispersion on mass. However, the best-fitting models underpredict the rotation and skewness of the stellar velocities. In the second field, centered on the core of the cluster, the mass segregation in proper motion is much stronger. Nevertheless the model developed in the outer field can be extended inward by taking this mass segregation into account in a heuristic fashion. The proper motions of the main-sequence stars yield a mass estimate of the cluster of \r\n at a distance of 4.7 kpc. By comparing the proper motions of a sample of giant and subgiant stars with the observed radial velocities we estimate the distance to the cluster kinematically to be 4.29 ± 0.47 kpc."}],"status":"public","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1710.10666","open_access":"1"}],"doi":"10.3847/1538-4357/aa974f","date_published":"2017-12-01T00:00:00Z","citation":{"short":"J. Heyl, I. Caiazzo, H. Richer, J. Anderson, J. Kalirai, J. Parada, The Astrophysical Journal 850 (2017).","ieee":"J. Heyl, I. Caiazzo, H. Richer, J. Anderson, J. Kalirai, and J. Parada, “Deep HST imaging in 47 Tucanae: A global dynamical model,” <i>The Astrophysical Journal</i>, vol. 850, no. 2. American Astronomical Society, 2017.","chicago":"Heyl, J., Ilaria Caiazzo, H. Richer, J. Anderson, J. Kalirai, and J. Parada. “Deep HST Imaging in 47 Tucanae: A Global Dynamical Model.” <i>The Astrophysical Journal</i>. American Astronomical Society, 2017. <a href=\"https://doi.org/10.3847/1538-4357/aa974f\">https://doi.org/10.3847/1538-4357/aa974f</a>.","ista":"Heyl J, Caiazzo I, Richer H, Anderson J, Kalirai J, Parada J. 2017. Deep HST imaging in 47 Tucanae: A global dynamical model. The Astrophysical Journal. 850(2), 186.","ama":"Heyl J, Caiazzo I, Richer H, Anderson J, Kalirai J, Parada J. Deep HST imaging in 47 Tucanae: A global dynamical model. <i>The Astrophysical Journal</i>. 2017;850(2). doi:<a href=\"https://doi.org/10.3847/1538-4357/aa974f\">10.3847/1538-4357/aa974f</a>","mla":"Heyl, J., et al. “Deep HST Imaging in 47 Tucanae: A Global Dynamical Model.” <i>The Astrophysical Journal</i>, vol. 850, no. 2, 186, American Astronomical Society, 2017, doi:<a href=\"https://doi.org/10.3847/1538-4357/aa974f\">10.3847/1538-4357/aa974f</a>.","apa":"Heyl, J., Caiazzo, I., Richer, H., Anderson, J., Kalirai, J., &#38; Parada, J. (2017). Deep HST imaging in 47 Tucanae: A global dynamical model. <i>The Astrophysical Journal</i>. American Astronomical Society. <a href=\"https://doi.org/10.3847/1538-4357/aa974f\">https://doi.org/10.3847/1538-4357/aa974f</a>"},"article_processing_charge":"No","article_number":"186","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","issue":"2","fulldoi":"https://doi.org/10.3847/1538-4357/aa974f","date_updated":"2024-04-08T07:04:35Z"},{"keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"fulldoi":"https://doi.org/10.1093/mnras/stx1036","date_updated":"2024-10-14T12:33:43Z","issue":"3","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","doi":"10.1093/mnras/stx1036","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1702.07682","open_access":"1"}],"status":"public","citation":{"short":"I. Caiazzo, J.S. Heyl, Monthly Notices of the Royal Astronomical Society 469 (2017) 2750–2759.","ieee":"I. Caiazzo and J. S. Heyl, “Polluting white dwarfs with perturbed exo-comets,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 469, no. 3. Oxford University Press, pp. 2750–2759, 2017.","ama":"Caiazzo I, Heyl JS. Polluting white dwarfs with perturbed exo-comets. <i>Monthly Notices of the Royal Astronomical Society</i>. 2017;469(3):2750-2759. doi:<a href=\"https://doi.org/10.1093/mnras/stx1036\">10.1093/mnras/stx1036</a>","chicago":"Caiazzo, Ilaria, and Jeremy S. Heyl. “Polluting White Dwarfs with Perturbed Exo-Comets.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2017. <a href=\"https://doi.org/10.1093/mnras/stx1036\">https://doi.org/10.1093/mnras/stx1036</a>.","ista":"Caiazzo I, Heyl JS. 2017. Polluting white dwarfs with perturbed exo-comets. Monthly Notices of the Royal Astronomical Society. 469(3), 2750–2759.","mla":"Caiazzo, Ilaria, and Jeremy S. Heyl. “Polluting White Dwarfs with Perturbed Exo-Comets.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 469, no. 3, Oxford University Press, 2017, pp. 2750–59, doi:<a href=\"https://doi.org/10.1093/mnras/stx1036\">10.1093/mnras/stx1036</a>.","apa":"Caiazzo, I., &#38; Heyl, J. S. (2017). Polluting white dwarfs with perturbed exo-comets. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stx1036\">https://doi.org/10.1093/mnras/stx1036</a>"},"date_published":"2017-05-01T00:00:00Z","external_id":{"arxiv":["1702.07682"]},"type":"journal_article","oa_version":"Preprint","abstract":[{"lang":"eng","text":"We present a model to account for the observed debris discs around young white dwarfs and the presence of metal lines in their spectra. Stellar evolution models predict that the mass-loss on the AGB will be pulsed; furthermore, observations indicate that the bulk of the mass-loss occurs on the AGB. In this case, if the progenitors of the white dwarfs had remnants of planetary formation like the Sun’s Oort cloud or the Kuiper Belt and a planet lying within that cloud or nearby, we find that up to 2 per cent of the planetesimals will fall either into planet-crossing orbits or into chaotic regions after the mass-loss, depending on the location and mass of the planet (from Mars to Neptune). This yields a sufficient mass of comets that can be scattered towards the star, form a debris disc and pollute the atmosphere."}],"month":"05","arxiv":1,"day":"01","volume":469,"publication":"Monthly Notices of the Royal Astronomical Society","intvolume":"       469","oa":1,"language":[{"iso":"eng"}],"year":"2017","page":"2750-2759","_id":"15241","date_created":"2024-03-26T10:40:45Z","extern":"1","article_type":"original","author":[{"first_name":"Ilaria","orcid":"0000-0002-4770-5388","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","full_name":"Caiazzo, Ilaria","last_name":"Caiazzo"},{"first_name":"Jeremy S.","last_name":"Heyl","full_name":"Heyl, Jeremy S."}],"quality_controlled":"1","title":"Polluting white dwarfs with perturbed exo-comets","scopus_import":"1","publisher":"Oxford University Press","publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]}},{"month":"07","abstract":[{"lang":"eng","text":"High-energy (>250 keV) emission has been detected persisting for several tens of seconds after the initial spike of magnetar giant flares (GFs). It has been conjectured that this emission might arise via inverse Compton scattering in a highly extended corona generated by super-Eddington outflows high up in the magnetosphere. In this paper, we undertake a detailed examination of this model. We investigate the properties of the required scatterers, and whether the mechanism is consistent with the degree of pulsed emission observed in the tail of the GF. We conclude that the mechanism is consistent with current data, although the origin of the scattering population remains an open question. We propose an alternative picture in which the emission is closer to that star and is dominated by synchrotron radiation. The Reuven Ramaty High Energy Solar Spectroscopic Imager observations of the 2004 December flare modestly favour this latter picture. We assess the prospects for the Fermi Gamma-ray Space Telescope to detect and characterize a similar high-energy component in a future GF. Such a detection should help to resolve some of the outstanding issues."}],"oa_version":"Preprint","external_id":{"arxiv":["1707.02922"]},"type":"journal_article","date_published":"2017-07-13T00:00:00Z","citation":{"apa":"Elenbaas, C., Huppenkothen, D., Omand, C., Watts, A. L., Bissaldi, E., Caiazzo, I., &#38; Heyl, J. (2017). Magnetar giant flare high-energy emission. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stx1727\">https://doi.org/10.1093/mnras/stx1727</a>","mla":"Elenbaas, C., et al. “Magnetar Giant Flare High-Energy Emission.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 471, no. 2, Oxford University Press, 2017, pp. 1856–72, doi:<a href=\"https://doi.org/10.1093/mnras/stx1727\">10.1093/mnras/stx1727</a>.","ama":"Elenbaas C, Huppenkothen D, Omand C, et al. Magnetar giant flare high-energy emission. <i>Monthly Notices of the Royal Astronomical Society</i>. 2017;471(2):1856-1872. doi:<a href=\"https://doi.org/10.1093/mnras/stx1727\">10.1093/mnras/stx1727</a>","chicago":"Elenbaas, C., D. Huppenkothen, C. Omand, A. L. Watts, E. Bissaldi, Ilaria Caiazzo, and J. Heyl. “Magnetar Giant Flare High-Energy Emission.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2017. <a href=\"https://doi.org/10.1093/mnras/stx1727\">https://doi.org/10.1093/mnras/stx1727</a>.","ista":"Elenbaas C, Huppenkothen D, Omand C, Watts AL, Bissaldi E, Caiazzo I, Heyl J. 2017. Magnetar giant flare high-energy emission. Monthly Notices of the Royal Astronomical Society. 471(2), 1856–1872.","ieee":"C. Elenbaas <i>et al.</i>, “Magnetar giant flare high-energy emission,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 471, no. 2. Oxford University Press, pp. 1856–1872, 2017.","short":"C. Elenbaas, D. Huppenkothen, C. Omand, A.L. Watts, E. Bissaldi, I. Caiazzo, J. Heyl, Monthly Notices of the Royal Astronomical Society 471 (2017) 1856–1872."},"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1707.02922"}],"doi":"10.1093/mnras/stx1727","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"2","publication_status":"published","date_updated":"2024-04-08T07:05:47Z","fulldoi":"https://doi.org/10.1093/mnras/stx1727","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]},"publisher":"Oxford University Press","scopus_import":"1","title":"Magnetar giant flare high-energy emission","quality_controlled":"1","author":[{"first_name":"C.","last_name":"Elenbaas","full_name":"Elenbaas, C."},{"full_name":"Huppenkothen, D.","last_name":"Huppenkothen","first_name":"D."},{"full_name":"Omand, C.","last_name":"Omand","first_name":"C."},{"first_name":"A. L.","last_name":"Watts","full_name":"Watts, A. L."},{"full_name":"Bissaldi, E.","last_name":"Bissaldi","first_name":"E."},{"orcid":"0000-0002-4770-5388","first_name":"Ilaria","full_name":"Caiazzo, Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","last_name":"Caiazzo"},{"first_name":"J.","last_name":"Heyl","full_name":"Heyl, J."}],"article_type":"original","extern":"1","date_created":"2024-03-26T10:41:24Z","_id":"15243","page":"1856-1872","year":"2017","language":[{"iso":"eng"}],"oa":1,"intvolume":"       471","publication":"Monthly Notices of the Royal Astronomical Society","volume":471,"day":"13","arxiv":1},{"day":"01","acknowledgement":"Z. Bao was supported by ERC Advanced Grant RANMAT No. 338804; L. Erdős was partially supported by ERC Advanced Grant RANMAT No. 338804.\r\nOpen access funding provided by Institute of Science and Technology (IST Austria). The authors are very grateful to the anonymous referees for careful reading and valuable comments, which helped to improve the organization.","publication":"Probability Theory and Related Fields","volume":167,"intvolume":"       167","oa":1,"language":[{"iso":"eng"}],"corr_author":"1","year":"2017","page":"673 - 776","_id":"1528","date_created":"2018-12-11T11:52:32Z","file_date_updated":"2020-07-14T12:45:00Z","author":[{"first_name":"Zhigang","orcid":"0000-0003-3036-1475","last_name":"Bao","id":"442E6A6C-F248-11E8-B48F-1D18A9856A87","full_name":"Bao, Zhigang"},{"first_name":"László","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","full_name":"Erdös, László"}],"article_type":"original","quality_controlled":"1","title":"Delocalization for a class of random block band matrices","scopus_import":"1","file":[{"creator":"system","relation":"main_file","access_level":"open_access","file_id":"4665","checksum":"67afa85ff1e220cbc1f9f477a828513c","file_size":1615755,"date_created":"2018-12-12T10:08:05Z","file_name":"IST-2016-489-v1+1_s00440-015-0692-y.pdf","date_updated":"2020-07-14T12:45:00Z","content_type":"application/pdf"}],"publisher":"Springer","publication_identifier":{"issn":["0178-8051"]},"fulldoi":"https://doi.org/10.1007/s00440-015-0692-y","date_updated":"2026-04-16T09:55:56Z","publication_status":"published","issue":"3-4","pubrep_id":"489","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","ec_funded":1,"department":[{"_id":"LaEr"}],"has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","license":"https://creativecommons.org/licenses/by/4.0/","isi":1,"doi":"10.1007/s00440-015-0692-y","project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Random matrices, universality and disordered quantum systems","grant_number":"338804"}],"status":"public","ddc":["530"],"citation":{"apa":"Bao, Z., &#38; Erdös, L. (2017). Delocalization for a class of random block band matrices. <i>Probability Theory and Related Fields</i>. Springer. <a href=\"https://doi.org/10.1007/s00440-015-0692-y\">https://doi.org/10.1007/s00440-015-0692-y</a>","mla":"Bao, Zhigang, and László Erdös. “Delocalization for a Class of Random Block Band Matrices.” <i>Probability Theory and Related Fields</i>, vol. 167, no. 3–4, Springer, 2017, pp. 673–776, doi:<a href=\"https://doi.org/10.1007/s00440-015-0692-y\">10.1007/s00440-015-0692-y</a>.","short":"Z. Bao, L. Erdös, Probability Theory and Related Fields 167 (2017) 673–776.","ieee":"Z. Bao and L. Erdös, “Delocalization for a class of random block band matrices,” <i>Probability Theory and Related Fields</i>, vol. 167, no. 3–4. Springer, pp. 673–776, 2017.","ista":"Bao Z, Erdös L. 2017. Delocalization for a class of random block band matrices. Probability Theory and Related Fields. 167(3–4), 673–776.","chicago":"Bao, Zhigang, and László Erdös. “Delocalization for a Class of Random Block Band Matrices.” <i>Probability Theory and Related Fields</i>. Springer, 2017. <a href=\"https://doi.org/10.1007/s00440-015-0692-y\">https://doi.org/10.1007/s00440-015-0692-y</a>.","ama":"Bao Z, Erdös L. Delocalization for a class of random block band matrices. <i>Probability Theory and Related Fields</i>. 2017;167(3-4):673-776. doi:<a href=\"https://doi.org/10.1007/s00440-015-0692-y\">10.1007/s00440-015-0692-y</a>"},"date_published":"2017-04-01T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"isi":["000398842700004"]},"type":"journal_article","publist_id":"5644","oa_version":"Published Version","abstract":[{"lang":"eng","text":"We consider N×N Hermitian random matrices H consisting of blocks of size M≥N6/7. The matrix elements are i.i.d. within the blocks, close to a Gaussian in the four moment matching sense, but their distribution varies from block to block to form a block-band structure, with an essential band width M. We show that the entries of the Green’s function G(z)=(H−z)−1 satisfy the local semicircle law with spectral parameter z=E+iη down to the real axis for any η≫N−1, using a combination of the supersymmetry method inspired by Shcherbina (J Stat Phys 155(3): 466–499, 2014) and the Green’s function comparison strategy. Previous estimates were valid only for η≫M−1. The new estimate also implies that the eigenvectors in the middle of the spectrum are fully delocalized."}],"month":"04"},{"_id":"169","date_created":"2018-12-11T11:44:59Z","citation":{"apa":"Browning, T. D., Kumaraswamy, V., &#38; Steiner, R. (2017). Twisted Linnik implies optimal covering exponent for S3. <i>International Mathematics Research Notices</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/imrn/rnx116\">https://doi.org/10.1093/imrn/rnx116</a>","mla":"Browning, Timothy D., et al. “Twisted Linnik Implies Optimal Covering Exponent for S3.” <i>International Mathematics Research Notices</i>, Oxford University Press, 2017, doi:<a href=\"https://doi.org/10.1093/imrn/rnx116\">10.1093/imrn/rnx116</a>.","ama":"Browning TD, Kumaraswamy V, Steiner R. Twisted Linnik implies optimal covering exponent for S3. <i>International Mathematics Research Notices</i>. 2017. doi:<a href=\"https://doi.org/10.1093/imrn/rnx116\">10.1093/imrn/rnx116</a>","chicago":"Browning, Timothy D, Vinay Kumaraswamy, and Rapael Steiner. “Twisted Linnik Implies Optimal Covering Exponent for S3.” <i>International Mathematics Research Notices</i>. Oxford University Press, 2017. <a href=\"https://doi.org/10.1093/imrn/rnx116\">https://doi.org/10.1093/imrn/rnx116</a>.","ista":"Browning TD, Kumaraswamy V, Steiner R. 2017. Twisted Linnik implies optimal covering exponent for S3. International Mathematics Research Notices.","ieee":"T. D. Browning, V. Kumaraswamy, and R. Steiner, “Twisted Linnik implies optimal covering exponent for S3,” <i>International Mathematics Research Notices</i>. Oxford University Press, 2017.","short":"T.D. Browning, V. Kumaraswamy, R. Steiner, International Mathematics Research Notices (2017)."},"extern":"1","date_published":"2017-06-19T00:00:00Z","doi":"10.1093/imrn/rnx116","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1609.06097"}],"status":"public","abstract":[{"text":"We show that a twisted variant of Linnik’s conjecture on sums of Kloosterman sums leads to an optimal covering exponent for S3.","lang":"eng"}],"month":"06","publisher":"Oxford University Press","author":[{"orcid":"0000-0002-8314-0177","first_name":"Timothy D","full_name":"Browning, Timothy D","id":"35827D50-F248-11E8-B48F-1D18A9856A87","last_name":"Browning"},{"full_name":"Kumaraswamy, Vinay","last_name":"Kumaraswamy","first_name":"Vinay"},{"first_name":"Rapael","full_name":"Steiner, Rapael","last_name":"Steiner"}],"type":"journal_article","external_id":{"arxiv":["1609.06097"]},"quality_controlled":"1","publist_id":"7752","title":"Twisted Linnik implies optimal covering exponent for S3","oa_version":"None","publication":"International Mathematics Research Notices","fulldoi":"https://doi.org/10.1093/imrn/rnx116","date_updated":"2021-01-12T06:52:32Z","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"19","arxiv":1,"language":[{"iso":"eng"}],"year":"2017","oa":1,"article_processing_charge":"No"},{"oa":1,"article_processing_charge":"No","year":"2017","language":[{"iso":"eng"}],"arxiv":1,"day":"30","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T06:52:45Z","fulldoi":"https://doi.org/10.1093/imrn/rnx252","publication":"International Mathematics Research Notices","publication_status":"published","quality_controlled":"1","publist_id":"7749","title":"Strong approximation and a conjecture of Harpaz and Wittenberg","oa_version":"None","author":[{"id":"35827D50-F248-11E8-B48F-1D18A9856A87","last_name":"Browning","full_name":"Browning, Timothy D","orcid":"0000-0002-8314-0177","first_name":"Timothy D"},{"full_name":"Schindler, Damaris","last_name":"Schindler","first_name":"Damaris"}],"type":"journal_article","external_id":{"arxiv":["1509.07744"]},"month":"10","publisher":"Oxford University Press","abstract":[{"lang":"eng","text":"We study strong approximation for some algebraic varieties over ℚ which are defined using norm forms. This allows us to confirm a special case of a conjecture due to Harpaz and Wittenberg."}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1509.07744"}],"status":"public","doi":"10.1093/imrn/rnx252","date_published":"2017-10-30T00:00:00Z","_id":"172","date_created":"2018-12-11T11:45:00Z","extern":"1","citation":{"apa":"Browning, T. D., &#38; Schindler, D. (2017). Strong approximation and a conjecture of Harpaz and Wittenberg. <i>International Mathematics Research Notices</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/imrn/rnx252\">https://doi.org/10.1093/imrn/rnx252</a>","mla":"Browning, Timothy D., and Damaris Schindler. “Strong Approximation and a Conjecture of Harpaz and Wittenberg.” <i>International Mathematics Research Notices</i>, Oxford University Press, 2017, doi:<a href=\"https://doi.org/10.1093/imrn/rnx252\">10.1093/imrn/rnx252</a>.","chicago":"Browning, Timothy D, and Damaris Schindler. “Strong Approximation and a Conjecture of Harpaz and Wittenberg.” <i>International Mathematics Research Notices</i>. Oxford University Press, 2017. <a href=\"https://doi.org/10.1093/imrn/rnx252\">https://doi.org/10.1093/imrn/rnx252</a>.","ama":"Browning TD, Schindler D. Strong approximation and a conjecture of Harpaz and Wittenberg. <i>International Mathematics Research Notices</i>. 2017. doi:<a href=\"https://doi.org/10.1093/imrn/rnx252\">10.1093/imrn/rnx252</a>","ista":"Browning TD, Schindler D. 2017. Strong approximation and a conjecture of Harpaz and Wittenberg. International Mathematics Research Notices.","short":"T.D. Browning, D. Schindler, International Mathematics Research Notices (2017).","ieee":"T. D. Browning and D. Schindler, “Strong approximation and a conjecture of Harpaz and Wittenberg,” <i>International Mathematics Research Notices</i>. Oxford University Press, 2017."}},{"date_published":"2017-10-01T00:00:00Z","citation":{"short":"A.M. Douglass, H. Kucukdereli, M. Ponserre, M. Markovic, J. Gründemann, C. Strobel, P.L. Alcala Morales, K.-K. Conzelmann, A. Lüthi, R. Klein, Nature Neuroscience 20 (2017) 1384–1394.","ieee":"A. M. Douglass <i>et al.</i>, “Central amygdala circuits modulate food consumption through a positive-valence mechanism,” <i>Nature Neuroscience</i>, vol. 20, no. 10. Springer Nature, pp. 1384–1394, 2017.","ama":"Douglass AM, Kucukdereli H, Ponserre M, et al. Central amygdala circuits modulate food consumption through a positive-valence mechanism. <i>Nature Neuroscience</i>. 2017;20(10):1384-1394. doi:<a href=\"https://doi.org/10.1038/nn.4623\">10.1038/nn.4623</a>","ista":"Douglass AM, Kucukdereli H, Ponserre M, Markovic M, Gründemann J, Strobel C, Alcala Morales PL, Conzelmann K-K, Lüthi A, Klein R. 2017. Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience. 20(10), 1384–1394.","chicago":"Douglass, Amelia M., Hakan Kucukdereli, Marion Ponserre, Milica Markovic, Jan Gründemann, Cornelia Strobel, Pilar L Alcala Morales, Karl-Klaus Conzelmann, Andreas Lüthi, and Rüdiger Klein. “Central Amygdala Circuits Modulate Food Consumption through a Positive-Valence Mechanism.” <i>Nature Neuroscience</i>. Springer Nature, 2017. <a href=\"https://doi.org/10.1038/nn.4623\">https://doi.org/10.1038/nn.4623</a>.","apa":"Douglass, A. M., Kucukdereli, H., Ponserre, M., Markovic, M., Gründemann, J., Strobel, C., … Klein, R. (2017). Central amygdala circuits modulate food consumption through a positive-valence mechanism. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nn.4623\">https://doi.org/10.1038/nn.4623</a>","mla":"Douglass, Amelia M., et al. “Central Amygdala Circuits Modulate Food Consumption through a Positive-Valence Mechanism.” <i>Nature Neuroscience</i>, vol. 20, no. 10, Springer Nature, 2017, pp. 1384–94, doi:<a href=\"https://doi.org/10.1038/nn.4623\">10.1038/nn.4623</a>."},"status":"public","main_file_link":[{"url":"https://doi.org/10.1101/145375","open_access":"1"}],"doi":"10.1038/nn.4623","OA_type":"green","month":"10","abstract":[{"lang":"eng","text":"The complex behaviors underlying reward seeking and consumption are integral to organism survival. The hypothalamus and mesolimbic dopamine system are key mediators of these behaviors, yet regulation of appetitive and consummatory behaviors outside of these regions is poorly understood. The central nucleus of the amygdala (CeA) has been implicated in feeding and reward, but the neurons and circuit mechanisms that positively regulate these behaviors remain unclear. Here, we defined the neuronal mechanisms by which CeA neurons promote food consumption. Using in vivo activity manipulations and Ca2+ imaging in mice, we found that GABAergic serotonin receptor 2a (Htr2a)-expressing CeA neurons modulate food consumption, promote positive reinforcement and are active in vivo during eating. We demonstrated electrophysiologically, anatomically and behaviorally that intra-CeA and long-range circuit mechanisms underlie these behaviors. Finally, we showed that CeAHtr2a neurons receive inputs from feeding-relevant brain regions. Our results illustrate how defined CeA neural circuits positively regulate food consumption."}],"oa_version":"Preprint","external_id":{"pmid":["28825719 "]},"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","issue":"10","date_updated":"2025-07-10T11:51:42Z","fulldoi":"https://doi.org/10.1038/nn.4623","pmid":1,"article_processing_charge":"No","extern":"1","page":"1384-1394","_id":"19474","date_created":"2025-04-03T12:30:57Z","publication_identifier":{"issn":["1097-6256"],"eissn":["1546-1726"]},"publisher":"Springer Nature","scopus_import":"1","title":"Central amygdala circuits modulate food consumption through a positive-valence mechanism","quality_controlled":"1","author":[{"orcid":"0000-0001-5398-6473","first_name":"Amelia May Barnett","last_name":"Douglass","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","full_name":"Douglass, Amelia May Barnett"},{"full_name":"Kucukdereli, Hakan","last_name":"Kucukdereli","first_name":"Hakan"},{"last_name":"Ponserre","full_name":"Ponserre, Marion","first_name":"Marion"},{"last_name":"Markovic","full_name":"Markovic, Milica","first_name":"Milica"},{"first_name":"Jan","last_name":"Gründemann","full_name":"Gründemann, Jan"},{"full_name":"Strobel, Cornelia","last_name":"Strobel","first_name":"Cornelia"},{"first_name":"Pilar L","last_name":"Alcala Morales","full_name":"Alcala Morales, Pilar L"},{"first_name":"Karl-Klaus","full_name":"Conzelmann, Karl-Klaus","last_name":"Conzelmann"},{"full_name":"Lüthi, Andreas","last_name":"Lüthi","first_name":"Andreas"},{"full_name":"Klein, Rüdiger","last_name":"Klein","first_name":"Rüdiger"}],"article_type":"original","publication":"Nature Neuroscience","volume":20,"day":"01","year":"2017","OA_place":"repository","language":[{"iso":"eng"}],"oa":1,"intvolume":"        20"},{"has_accepted_license":"1","article_processing_charge":"No","date_updated":"2025-09-18T10:03:47Z","fulldoi":"https://doi.org/10.1186/s40170-017-0164-1","issue":"2","publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","type":"journal_article","external_id":{"isi":["000396463900001"]},"publist_id":"7380","oa_version":"Published Version","abstract":[{"text":"Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic strategy for cancers such as pancreatic cancer, which are driven by genetic alterations that are not tractable drug targets. Although somatic mitochondrial genome (mtDNA) mutations have been observed in various tumors types, understanding of metabolic genotype-phenotype relationships is limited.","lang":"eng"}],"month":"01","doi":"10.1186/s40170-017-0164-1","isi":1,"status":"public","citation":{"ieee":"R. Hardie <i>et al.</i>, “Mitochondrial mutations and metabolic adaptation in pancreatic cancer,” <i>Cancer &#38; Metabolism</i>, vol. 5, no. 2. BioMed Central, 2017.","short":"R. Hardie, E. Van Dam, M. Cowley, T. Han, S. Balaban, M. Pajic, M. Pinese, M. Iconomou, R. Shearer, J. Mckenna, D. Miller, N. Waddell, J. Pearson, S. Grimmond, L.A. Sazanov, A. Biankin, S. Villas Boas, A. Hoy, N. Turner, D. Saunders, Cancer &#38; Metabolism 5 (2017).","chicago":"Hardie, Rae, Ellen Van Dam, Mark Cowley, Ting Han, Seher Balaban, Marina Pajic, Mark Pinese, et al. “Mitochondrial Mutations and Metabolic Adaptation in Pancreatic Cancer.” <i>Cancer &#38; Metabolism</i>. BioMed Central, 2017. <a href=\"https://doi.org/10.1186/s40170-017-0164-1\">https://doi.org/10.1186/s40170-017-0164-1</a>.","ama":"Hardie R, Van Dam E, Cowley M, et al. Mitochondrial mutations and metabolic adaptation in pancreatic cancer. <i>Cancer &#38; Metabolism</i>. 2017;5(2). doi:<a href=\"https://doi.org/10.1186/s40170-017-0164-1\">10.1186/s40170-017-0164-1</a>","ista":"Hardie R, Van Dam E, Cowley M, Han T, Balaban S, Pajic M, Pinese M, Iconomou M, Shearer R, Mckenna J, Miller D, Waddell N, Pearson J, Grimmond S, Sazanov LA, Biankin A, Villas Boas S, Hoy A, Turner N, Saunders D. 2017. Mitochondrial mutations and metabolic adaptation in pancreatic cancer. Cancer &#38; Metabolism. 5(2).","apa":"Hardie, R., Van Dam, E., Cowley, M., Han, T., Balaban, S., Pajic, M., … Saunders, D. (2017). Mitochondrial mutations and metabolic adaptation in pancreatic cancer. <i>Cancer &#38; Metabolism</i>. BioMed Central. <a href=\"https://doi.org/10.1186/s40170-017-0164-1\">https://doi.org/10.1186/s40170-017-0164-1</a>","mla":"Hardie, Rae, et al. “Mitochondrial Mutations and Metabolic Adaptation in Pancreatic Cancer.” <i>Cancer &#38; Metabolism</i>, vol. 5, no. 2, BioMed Central, 2017, doi:<a href=\"https://doi.org/10.1186/s40170-017-0164-1\">10.1186/s40170-017-0164-1</a>."},"ddc":["570"],"date_published":"2017-01-30T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"intvolume":"         5","oa":1,"language":[{"iso":"eng"}],"year":"2017","day":"30","publication":"Cancer & Metabolism","volume":5,"author":[{"full_name":"Hardie, Rae","last_name":"Hardie","first_name":"Rae"},{"first_name":"Ellen","last_name":"Van Dam","full_name":"Van Dam, Ellen"},{"first_name":"Mark","full_name":"Cowley, Mark","last_name":"Cowley"},{"full_name":"Han, Ting","last_name":"Han","first_name":"Ting"},{"first_name":"Seher","full_name":"Balaban, Seher","last_name":"Balaban"},{"full_name":"Pajic, Marina","last_name":"Pajic","first_name":"Marina"},{"first_name":"Mark","last_name":"Pinese","full_name":"Pinese, Mark"},{"first_name":"Mary","last_name":"Iconomou","full_name":"Iconomou, Mary"},{"last_name":"Shearer","full_name":"Shearer, Robert","first_name":"Robert"},{"first_name":"Jessie","last_name":"Mckenna","full_name":"Mckenna, Jessie"},{"full_name":"Miller, David","last_name":"Miller","first_name":"David"},{"first_name":"Nicola","full_name":"Waddell, Nicola","last_name":"Waddell"},{"first_name":"John","last_name":"Pearson","full_name":"Pearson, John"},{"last_name":"Grimmond","full_name":"Grimmond, Sean","first_name":"Sean"},{"orcid":"0000-0002-0977-7989","first_name":"Leonid A","last_name":"Sazanov","full_name":"Sazanov, Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Andrew","full_name":"Biankin, Andrew","last_name":"Biankin"},{"first_name":"Silas","last_name":"Villas Boas","full_name":"Villas Boas, Silas"},{"last_name":"Hoy","full_name":"Hoy, Andrew","first_name":"Andrew"},{"first_name":"Nigel","last_name":"Turner","full_name":"Turner, Nigel"},{"full_name":"Saunders, Darren","last_name":"Saunders","first_name":"Darren"}],"quality_controlled":"1","title":"Mitochondrial mutations and metabolic adaptation in pancreatic cancer","file":[{"checksum":"337a65786875f64a1fe9fc0ac24767dc","relation":"main_file","creator":"dernst","access_level":"open_access","file_id":"5868","file_size":1609174,"file_name":"2017_Cancer_Hardie.pdf","date_updated":"2020-07-14T12:46:29Z","date_created":"2019-01-22T08:17:56Z","content_type":"application/pdf"}],"publisher":"BioMed Central","_id":"443","date_created":"2018-12-11T11:46:30Z","extern":"1","file_date_updated":"2020-07-14T12:46:29Z"},{"day":"29","series_title":"Mechanisms of Primary Energy Transduction in Biology ","publication_status":"published","fulldoi":"https://doi.org/10.1039/9781788010405-00025","publication":"Mechanisms of primary energy transduction in biology ","date_updated":"2024-10-09T20:58:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"LeSa"}],"editor":[{"first_name":"Mårten","last_name":"Wikström","full_name":"Wikström, Mårten"}],"corr_author":"1","language":[{"iso":"eng"}],"year":"2017","doi":"10.1039/9781788010405-00025","status":"public","citation":{"apa":"Sazanov, L. A. (2017). Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions. In M. Wikström (Ed.), <i>Mechanisms of primary energy transduction in biology </i> (pp. 25–59). Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/9781788010405-00025\">https://doi.org/10.1039/9781788010405-00025</a>","mla":"Sazanov, Leonid A. “Structure of Respiratory Complex I: ‘Minimal’ Bacterial and ‘de Luxe’ Mammalian Versions.” <i>Mechanisms of Primary Energy Transduction in Biology </i>, edited by Mårten Wikström, Royal Society of Chemistry, 2017, pp. 25–59, doi:<a href=\"https://doi.org/10.1039/9781788010405-00025\">10.1039/9781788010405-00025</a>.","ieee":"L. A. Sazanov, “Structure of respiratory complex I: ‘Minimal’ bacterial and ‘de luxe’ mammalian versions,” in <i>Mechanisms of primary energy transduction in biology </i>, M. Wikström, Ed. Royal Society of Chemistry, 2017, pp. 25–59.","short":"L.A. Sazanov, in:, M. Wikström (Ed.), Mechanisms of Primary Energy Transduction in Biology , Royal Society of Chemistry, 2017, pp. 25–59.","ista":"Sazanov LA. 2017.Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions. In: Mechanisms of primary energy transduction in biology . , 25–59.","ama":"Sazanov LA. Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions. In: Wikström M, ed. <i>Mechanisms of Primary Energy Transduction in Biology </i>. Mechanisms of Primary Energy Transduction in Biology . Royal Society of Chemistry; 2017:25-59. doi:<a href=\"https://doi.org/10.1039/9781788010405-00025\">10.1039/9781788010405-00025</a>","chicago":"Sazanov, Leonid A. “Structure of Respiratory Complex I: ‘Minimal’ Bacterial and ‘de Luxe’ Mammalian Versions.” In <i>Mechanisms of Primary Energy Transduction in Biology </i>, edited by Mårten Wikström, 25–59. Mechanisms of Primary Energy Transduction in Biology . Royal Society of Chemistry, 2017. <a href=\"https://doi.org/10.1039/9781788010405-00025\">https://doi.org/10.1039/9781788010405-00025</a>."},"_id":"444","date_created":"2018-12-11T11:46:30Z","page":"25 - 59","date_published":"2017-11-29T00:00:00Z","type":"book_chapter","author":[{"orcid":"0000-0002-0977-7989","first_name":"Leonid A","last_name":"Sazanov","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","full_name":"Sazanov, Leonid A"}],"oa_version":"None","title":"Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions","quality_controlled":"1","publist_id":"7379","abstract":[{"text":"Complex I (NADH:ubiquinone oxidoreductase) plays a central role in cellular energy generation, contributing to the proton motive force used to produce ATP. It couples the transfer of two electrons between NADH and quinone to translocation of four protons across the membrane. It is the largest protein assembly of bacterial and mitochondrial respiratory chains, composed, in mammals, of up to 45 subunits with a total molecular weight of ∼1 MDa. Bacterial enzyme is about half the size, providing the important “minimal” model of complex I. The l-shaped complex consists of a hydrophilic arm, where electron transfer occurs, and a membrane arm, where proton translocation takes place. Previously, we have solved the crystal structures of the hydrophilic domain of complex I from Thermus thermophilus and of the membrane domain from Escherichia coli, followed by the atomic structure of intact, entire complex I from T. thermophilus. Recently, we have solved by cryo-EM a first complete atomic structure of mammalian (ovine) mitochondrial complex I. Core subunits are well conserved from the bacterial version, whilst supernumerary subunits form an interlinked, stabilizing shell around the core. Subunits containing additional cofactors, including Zn ion, NADPH and phosphopantetheine, probably have regulatory roles. Dysfunction of mitochondrial complex I is implicated in many human neurodegenerative diseases. The structure of mammalian enzyme provides many insights into complex I mechanism, assembly, maturation and dysfunction, allowing detailed molecular analysis of disease-causing mutations.","lang":"eng"}],"publication_identifier":{"isbn":["978-1-78262-865-1"]},"publisher":"Royal Society of Chemistry","month":"11"},{"acknowledgement":"This research was supported in part by the National\r\nScience Foundation under Grant No. NSF PHY11-25915.\r\nM.S. was supported by Gordon and Betty Moore Foundation’s\r\nEPiQS Initiative through Grant No. GBMF4307. D.A. also\r\nacknowledges support by Swiss National Science Foundation.","day":"12","arxiv":1,"publication":"Physical Review B - Condensed Matter and Materials Physics","volume":96,"oa":1,"intvolume":"        96","year":"2017","language":[{"iso":"eng"}],"extern":"1","date_created":"2018-12-11T11:46:31Z","_id":"445","title":"Loschmidt echo in many body localized phases","author":[{"orcid":"0000-0002-2399-5827","first_name":"Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","last_name":"Serbyn","full_name":"Serbyn, Maksym"},{"full_name":"Abanin, Dimitry","last_name":"Abanin","first_name":"Dimitry"}],"publisher":"American Physical Society","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"1","publication_status":"published","date_updated":"2025-09-04T06:59:31Z","fulldoi":"https://doi.org/10.1103/PhysRevB.96.014202","article_processing_charge":"No","status":"public","main_file_link":[{"url":"https://arxiv.org/abs/1701.07772","open_access":"1"}],"doi":"10.1103/PhysRevB.96.014202","date_published":"2017-07-12T00:00:00Z","citation":{"mla":"Serbyn, Maksym, and Dimitry Abanin. “Loschmidt Echo in Many Body Localized Phases.” <i>Physical Review B - Condensed Matter and Materials Physics</i>, vol. 96, no. 1, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevB.96.014202\">10.1103/PhysRevB.96.014202</a>.","apa":"Serbyn, M., &#38; Abanin, D. (2017). Loschmidt echo in many body localized phases. <i>Physical Review B - Condensed Matter and Materials Physics</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.96.014202\">https://doi.org/10.1103/PhysRevB.96.014202</a>","ama":"Serbyn M, Abanin D. Loschmidt echo in many body localized phases. <i>Physical Review B - Condensed Matter and Materials Physics</i>. 2017;96(1). doi:<a href=\"https://doi.org/10.1103/PhysRevB.96.014202\">10.1103/PhysRevB.96.014202</a>","ista":"Serbyn M, Abanin D. 2017. Loschmidt echo in many body localized phases. Physical Review B - Condensed Matter and Materials Physics. 96(1).","chicago":"Serbyn, Maksym, and Dimitry Abanin. “Loschmidt Echo in Many Body Localized Phases.” <i>Physical Review B - Condensed Matter and Materials Physics</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevB.96.014202\">https://doi.org/10.1103/PhysRevB.96.014202</a>.","short":"M. Serbyn, D. Abanin, Physical Review B - Condensed Matter and Materials Physics 96 (2017).","ieee":"M. Serbyn and D. Abanin, “Loschmidt echo in many body localized phases,” <i>Physical Review B - Condensed Matter and Materials Physics</i>, vol. 96, no. 1. American Physical Society, 2017."},"oa_version":"Preprint","publist_id":"7378","type":"journal_article","external_id":{"arxiv":["1701.07772"]},"month":"07","abstract":[{"text":"The Loschmidt echo, defined as the overlap between quantum wave function evolved with different Hamiltonians, quantifies the sensitivity of quantum dynamics to perturbations and is often used as a probe of quantum chaos. In this work we consider the behavior of the Loschmidt echo in the many-body localized phase, which is characterized by emergent local integrals of motion and provides a generic example of nonergodic dynamics. We demonstrate that the fluctuations of the Loschmidt echo decay as a power law in time in the many-body localized phase, in contrast to the exponential decay in few-body ergodic systems. We consider the spin-echo generalization of the Loschmidt echo and argue that the corresponding correlation function saturates to a finite value in localized systems. Slow, power-law decay of fluctuations of such spin-echo-type overlap is related to the operator spreading and is present only in the many-body localized phase, but not in a noninteracting Anderson insulator. While most of the previously considered probes of dephasing dynamics could be understood by approximating physical spin operators with local integrals of motion, the Loschmidt echo and its generalizations crucially depend on the full expansion of the physical operators via local integrals of motion operators, as well as operators which flip local integrals of motion. Hence these probes allow one to get insights into the relation between physical operators and local integrals of motion and access the operator spreading in the many-body localized phase.","lang":"eng"}]},{"year":"2017","language":[{"iso":"eng"}],"corr_author":"1","oa":1,"intvolume":"         9","volume":9,"publication":"Revista Latino-Americana de Probabilidade e Estatística","day":"23","publisher":"Instituto Nacional de Matematica Pura e Aplicada","scopus_import":"1","quality_controlled":"1","title":"Fluctuations of the competition interface in presence of shocks","article_type":"original","author":[{"first_name":"Patrik","full_name":"Ferrari, Patrik","last_name":"Ferrari"},{"first_name":"Peter","last_name":"Nejjar","full_name":"Nejjar, Peter","id":"4BF426E2-F248-11E8-B48F-1D18A9856A87"}],"date_created":"2018-12-11T11:46:31Z","_id":"447","page":"299 - 325","article_processing_charge":"No","department":[{"_id":"LaEr"},{"_id":"JaMa"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","ec_funded":1,"fulldoi":"https://doi.org/10.30757/ALEA.v14-17","date_updated":"2025-09-18T10:02:36Z","publication_status":"published","month":"03","abstract":[{"text":"We consider last passage percolation (LPP) models with exponentially distributed random variables, which are linked to the totally asymmetric simple exclusion process (TASEP). The competition interface for LPP was introduced and studied in Ferrari and Pimentel (2005a) for cases where the corresponding exclusion process had a rarefaction fan. Here we consider situations with a shock and determine the law of the fluctuations of the competition interface around its deter- ministic law of large number position. We also study the multipoint distribution of the LPP around the shock, extending our one-point result of Ferrari and Nejjar (2015).","lang":"eng"}],"publist_id":"7376","oa_version":"Submitted Version","external_id":{"isi":["000404011700017"]},"type":"journal_article","date_published":"2017-03-23T00:00:00Z","citation":{"ieee":"P. Ferrari and P. Nejjar, “Fluctuations of the competition interface in presence of shocks,” <i>Revista Latino-Americana de Probabilidade e Estatística</i>, vol. 9. Instituto Nacional de Matematica Pura e Aplicada, pp. 299–325, 2017.","short":"P. Ferrari, P. Nejjar, Revista Latino-Americana de Probabilidade e Estatística 9 (2017) 299–325.","ama":"Ferrari P, Nejjar P. Fluctuations of the competition interface in presence of shocks. <i>Revista Latino-Americana de Probabilidade e Estatística</i>. 2017;9:299-325. doi:<a href=\"https://doi.org/10.30757/ALEA.v14-17\">10.30757/ALEA.v14-17</a>","ista":"Ferrari P, Nejjar P. 2017. Fluctuations of the competition interface in presence of shocks. Revista Latino-Americana de Probabilidade e Estatística. 9, 299–325.","chicago":"Ferrari, Patrik, and Peter Nejjar. “Fluctuations of the Competition Interface in Presence of Shocks.” <i>Revista Latino-Americana de Probabilidade e Estatística</i>. Instituto Nacional de Matematica Pura e Aplicada, 2017. <a href=\"https://doi.org/10.30757/ALEA.v14-17\">https://doi.org/10.30757/ALEA.v14-17</a>.","apa":"Ferrari, P., &#38; Nejjar, P. (2017). Fluctuations of the competition interface in presence of shocks. <i>Revista Latino-Americana de Probabilidade e Estatística</i>. Instituto Nacional de Matematica Pura e Aplicada. <a href=\"https://doi.org/10.30757/ALEA.v14-17\">https://doi.org/10.30757/ALEA.v14-17</a>","mla":"Ferrari, Patrik, and Peter Nejjar. “Fluctuations of the Competition Interface in Presence of Shocks.” <i>Revista Latino-Americana de Probabilidade e Estatística</i>, vol. 9, Instituto Nacional de Matematica Pura e Aplicada, 2017, pp. 299–325, doi:<a href=\"https://doi.org/10.30757/ALEA.v14-17\">10.30757/ALEA.v14-17</a>."},"main_file_link":[{"open_access":"1","url":"http://alea.impa.br/articles/v14/14-17.pdf"}],"status":"public","project":[{"call_identifier":"FP7","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","name":"Random matrices, universality and disordered quantum systems"}],"doi":"10.30757/ALEA.v14-17","isi":1},{"publist_id":"7370","oa_version":"None","type":"journal_article","month":"08","related_material":{"record":[{"relation":"earlier_version","id":"2080","status":"public"}]},"abstract":[{"text":"Spinning tops and yo-yos have long fascinated cultures around the world with their unexpected, graceful motions that seemingly elude gravity. Yet, due to the exceeding difficulty of creating stably spinning objects of asymmetric shape in a manual trial-and-error process, there has been little departure from rotationally symmetric designs. With modern 3D printing technologies, however, we can manufacture shapes of almost unbounded complexity at the press of a button, shifting this design complexity toward computation. In this article, we describe an algorithm to generate designs for spinning objects by optimizing their mass distribution: as input, the user provides a solid 3D model and a desired axis of rotation. Our approach then modifies the interior mass distribution such that the principal directions of the moment of inertia align with the target rotation frame. To create voids inside the model, we represent its volume with an adaptive multiresolution voxelization and optimize the discrete voxel fill values using a continuous, nonlinear formulation. We further optimize for rotational stability by maximizing the dominant principal moment. Our method is well-suited for a variety of 3D printed models, ranging from characters to abstract shapes. We demonstrate tops and yo-yos that spin surprisingly stably despite their asymmetric appearance.","lang":"eng"}],"status":"public","doi":"10.1145/3068766","date_published":"2017-08-01T00:00:00Z","citation":{"short":"M. Bächer, B. Bickel, E. Whiting, O. Sorkine Hornung, Communications of the ACM 60 (2017) 92–99.","ieee":"M. Bächer, B. Bickel, E. Whiting, and O. Sorkine Hornung, “Spin it: Optimizing moment of inertia for spinnable objects,” <i>Communications of the ACM</i>, vol. 60, no. 8. ACM, pp. 92–99, 2017.","ama":"Bächer M, Bickel B, Whiting E, Sorkine Hornung O. Spin it: Optimizing moment of inertia for spinnable objects. <i>Communications of the ACM</i>. 2017;60(8):92-99. doi:<a href=\"https://doi.org/10.1145/3068766\">10.1145/3068766</a>","chicago":"Bächer, Moritz, Bernd Bickel, Emily Whiting, and Olga Sorkine Hornung. “Spin It: Optimizing Moment of Inertia for Spinnable Objects.” <i>Communications of the ACM</i>. ACM, 2017. <a href=\"https://doi.org/10.1145/3068766\">https://doi.org/10.1145/3068766</a>.","ista":"Bächer M, Bickel B, Whiting E, Sorkine Hornung O. 2017. Spin it: Optimizing moment of inertia for spinnable objects. Communications of the ACM. 60(8), 92–99.","apa":"Bächer, M., Bickel, B., Whiting, E., &#38; Sorkine Hornung, O. (2017). Spin it: Optimizing moment of inertia for spinnable objects. <i>Communications of the ACM</i>. ACM. <a href=\"https://doi.org/10.1145/3068766\">https://doi.org/10.1145/3068766</a>","mla":"Bächer, Moritz, et al. “Spin It: Optimizing Moment of Inertia for Spinnable Objects.” <i>Communications of the ACM</i>, vol. 60, no. 8, ACM, 2017, pp. 92–99, doi:<a href=\"https://doi.org/10.1145/3068766\">10.1145/3068766</a>."},"article_processing_charge":"No","department":[{"_id":"BeBi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-08-05T14:20:24Z","fulldoi":"https://doi.org/10.1145/3068766","issue":"8","publication_status":"published","quality_controlled":"1","title":"Spin it: Optimizing moment of inertia for spinnable objects","author":[{"first_name":"Moritz","last_name":"Bächer","full_name":"Bächer, Moritz"},{"orcid":"0000-0001-6511-9385","first_name":"Bernd","last_name":"Bickel","id":"49876194-F248-11E8-B48F-1D18A9856A87","full_name":"Bickel, Bernd"},{"first_name":"Emily","full_name":"Whiting, Emily","last_name":"Whiting"},{"full_name":"Sorkine Hornung, Olga","last_name":"Sorkine Hornung","first_name":"Olga"}],"article_type":"original","publisher":"ACM","scopus_import":"1","date_created":"2018-12-11T11:46:33Z","_id":"452","page":"92 - 99","intvolume":"        60","year":"2017","language":[{"iso":"eng"}],"day":"01","acknowledgement":"This project was supported in part by the ERC Starting Grant iModel (StG-2012-306877). Emily Whiting was supported by the ETH Zurich/Marie Curie COFUND Postdoctoral Fellowship. \r\nFirst and foremost, we would like to thank our editor Steve Marschner for his invaluable feedback. We were fortunate to get further help from Maurizio Nitti for model design, Romain Prévost for Make-It-Stand comparisons, Alexander Sorkine-Hornung, Kaan Yücer, and Changil Kim for video and photo assistance, Ronnie Gänsli for metal casting, Alec Jacobson for the posed Elephant and Armadillo models, and Romain Prévost and Amit Bermano for print preparation. Model sources include: Woven Ring: generated by “Sculpture Generator 1” by Carlo H. Séquin, UC Berkeley; Elephant: De Espona model library, courtesy of Robert Sumner; T-Rex: TurboSquid; Armadillo: Stanford Computer Graphics Laboratory; and Utah Teapot: Martin Newell, University of Utah. ","volume":60,"publication":"Communications of the ACM"},{"doi":"10.1016/j.bpj.2017.09.006","OA_type":"hybrid","status":"public","ddc":["570"],"citation":{"apa":"Fallesen, T., Roostalu, J., Düllberg, C. F., Pruessner, G., &#38; Surrey, T. (2017). Ensembles of bidirectional kinesin Cin8 produce additive forces in both directions of movement. <i>Biophysical Journal</i>. Biophysical Society. <a href=\"https://doi.org/10.1016/j.bpj.2017.09.006\">https://doi.org/10.1016/j.bpj.2017.09.006</a>","mla":"Fallesen, Todd, et al. “Ensembles of Bidirectional Kinesin Cin8 Produce Additive Forces in Both Directions of Movement.” <i>Biophysical Journal</i>, vol. 113, no. 9, Biophysical Society, 2017, pp. 2055–67, doi:<a href=\"https://doi.org/10.1016/j.bpj.2017.09.006\">10.1016/j.bpj.2017.09.006</a>.","ista":"Fallesen T, Roostalu J, Düllberg CF, Pruessner G, Surrey T. 2017. Ensembles of bidirectional kinesin Cin8 produce additive forces in both directions of movement. Biophysical Journal. 113(9), 2055–2067.","chicago":"Fallesen, Todd, Johanna Roostalu, Christian F Düllberg, Gunnar Pruessner, and Thomas Surrey. “Ensembles of Bidirectional Kinesin Cin8 Produce Additive Forces in Both Directions of Movement.” <i>Biophysical Journal</i>. Biophysical Society, 2017. <a href=\"https://doi.org/10.1016/j.bpj.2017.09.006\">https://doi.org/10.1016/j.bpj.2017.09.006</a>.","ama":"Fallesen T, Roostalu J, Düllberg CF, Pruessner G, Surrey T. Ensembles of bidirectional kinesin Cin8 produce additive forces in both directions of movement. <i>Biophysical Journal</i>. 2017;113(9):2055-2067. doi:<a href=\"https://doi.org/10.1016/j.bpj.2017.09.006\">10.1016/j.bpj.2017.09.006</a>","ieee":"T. Fallesen, J. Roostalu, C. F. Düllberg, G. Pruessner, and T. Surrey, “Ensembles of bidirectional kinesin Cin8 produce additive forces in both directions of movement,” <i>Biophysical Journal</i>, vol. 113, no. 9. Biophysical Society, pp. 2055–2067, 2017.","short":"T. Fallesen, J. Roostalu, C.F. Düllberg, G. Pruessner, T. Surrey, Biophysical Journal 113 (2017) 2055–2067."},"date_published":"2017-11-07T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"pmid":["29117528"]},"type":"journal_article","oa_version":"Published Version","publist_id":"7369","abstract":[{"lang":"eng","text":"Most kinesin motors move in only one direction along microtubules. Members of the kinesin-5 subfamily were initially described as unidirectional plus-end-directed motors and shown to produce piconewton forces. However, some fungal kinesin-5 motors are bidirectional. The force production of a bidirectional kinesin-5 has not yet been measured. Therefore, it remains unknown whether the mechanism of the unconventional minus-end-directed motility differs fundamentally from that of plus-end-directed stepping. Using force spectroscopy, we have measured here the forces that ensembles of purified budding yeast kinesin-5 Cin8 produce in microtubule gliding assays in both plus- and minus-end direction. Correlation analysis of pause forces demonstrated that individual Cin8 molecules produce additive forces in both directions of movement. In ensembles, Cin8 motors were able to produce single-motor forces up to a magnitude of ∼1.5 pN. Hence, these properties appear to be conserved within the kinesin-5 subfamily. Force production was largely independent of the directionality of movement, indicating similarities between the motility mechanisms for both directions. These results provide constraints for the development of models for the bidirectional motility mechanism of fission yeast kinesin-5 and provide insight into the function of this mitotic motor."}],"month":"11","pubrep_id":"965","publication_status":"published","issue":"9","fulldoi":"https://doi.org/10.1016/j.bpj.2017.09.006","date_updated":"2025-08-05T14:08:52Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MaLo"}],"article_processing_charge":"No","has_accepted_license":"1","pmid":1,"file_date_updated":"2020-07-14T12:46:31Z","_id":"453","page":"2055 - 2067","date_created":"2018-12-11T11:46:33Z","article_type":"original","author":[{"full_name":"Fallesen, Todd","last_name":"Fallesen","first_name":"Todd"},{"full_name":"Roostalu, Johanna","last_name":"Roostalu","first_name":"Johanna"},{"orcid":"0000-0001-6335-9748","first_name":"Christian F","id":"459064DC-F248-11E8-B48F-1D18A9856A87","last_name":"Düllberg","full_name":"Düllberg, Christian F"},{"first_name":"Gunnar","last_name":"Pruessner","full_name":"Pruessner, Gunnar"},{"first_name":"Thomas","last_name":"Surrey","full_name":"Surrey, Thomas"}],"title":"Ensembles of bidirectional kinesin Cin8 produce additive forces in both directions of movement","quality_controlled":"1","file":[{"creator":"system","relation":"main_file","file_id":"5052","access_level":"open_access","checksum":"99a2474088e20ac74b1882c4fbbb45b1","file_size":977192,"content_type":"application/pdf","file_name":"IST-2018-965-v1+1_2017_Duellberg_Ensembles_of.pdf","date_updated":"2020-07-14T12:46:31Z","date_created":"2018-12-12T10:14:03Z"}],"scopus_import":"1","publication_identifier":{"issn":["0006-3495"],"eissn":["1542-0086"]},"publisher":"Biophysical Society","acknowledgement":"The plasmid for full-length kinesin-1 was a gift from G. Holzwarth and J. Macosko with permission from J. Howard. We thank I. Lueke and N. I. Cade for technical assistance. G.P. thanks the Francis Crick Institute, and in particular the Surrey and Salbreux groups, for their hospitality during his sabbatical stay, as well as Imperial College London for making it possible. This work was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001163), the United Kingdom Medical Research Council (FC001163), and the Wellcome Trust (FC001163), and by Imperial College London. J.R. was also supported by a Sir Henry Wellcome Postdoctoral Fellowship (100145/Z/12/Z) and T.S. by the European Research Council (Advanced Grant, project 323042). ","day":"07","publication":"Biophysical Journal","volume":113,"intvolume":"       113","oa":1,"OA_place":"publisher","language":[{"iso":"eng"}],"year":"2017"},{"license":"https://creativecommons.org/licenses/by-nd/4.0/","has_accepted_license":"1","article_processing_charge":"No","department":[{"_id":"SyCr"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-10-09T20:58:13Z","publication_status":"published","pubrep_id":"962","month":"04","abstract":[{"lang":"eng","text":"The social insects bees, wasps, ants, and termites are species-rich, occur in many habitats, and often constitute a large part of the biomass. Many are also invasive, including species of termites, the red imported fire ant, and the Argentine ant. While invasive social insects have been a problem in Southern Europe for some time, Central Europa was free of invasive ant species until recently because most ants are adapted to warmer climates. Only in the 1990s, did Lasius neglectus, a close relative of the common black garden ant, arrive in Germany. First described in 1990 based on individuals collected in Budapest, the species has since been detected for example in France, Germany, Spain, England, and Kyrgyzstan. The species is spread with soil during construction work or plantings, and L. neglectus therefore is often found in parks and botanical gardens. Another invasive ant now spreading in southern Germany is Formica fuscocinerea, which occurs along rivers, including in the sandy floodplains of the river Isar. As is typical of pioneer species, F. fuscocinerea quickly becomes extremely abundant and therefore causes problems for example on playgrounds in Munich. All invasive ant species are characterized by cooperation across nests, leading to strongly interconnected, very large super-colonies. The resulting dominance results in the extinction of native ant species as well as other arthropod species and thus in the reduction of biodiversity."}],"publist_id":"7362","oa_version":"Published Version","type":"journal_article","date_published":"2017-04-04T00:00:00Z","tmp":{"short":"CC BY-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nd/4.0/legalcode","name":"Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)","image":"/image/cc_by_nd.png"},"citation":{"mla":"Cremer, Sylvia. “Invasive Ameisen in Europa: Wie Sie Sich Ausbreiten Und Die Heimische Fauna Verändern.” <i>Rundgespräche Forum Ökologie</i>, vol. 46, Verlag Dr. Friedrich Pfeil, 2017, pp. 105–16.","apa":"Cremer, S. (2017). Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern. <i>Rundgespräche Forum Ökologie</i>. Verlag Dr. Friedrich Pfeil.","short":"S. Cremer, Rundgespräche Forum Ökologie 46 (2017) 105–116.","ieee":"S. Cremer, “Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern,” <i>Rundgespräche Forum Ökologie</i>, vol. 46. Verlag Dr. Friedrich Pfeil, pp. 105–116, 2017.","ista":"Cremer S. 2017. Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern. Rundgespräche Forum Ökologie. 46, 105–116.","chicago":"Cremer, Sylvia. “Invasive Ameisen in Europa: Wie Sie Sich Ausbreiten Und Die Heimische Fauna Verändern.” <i>Rundgespräche Forum Ökologie</i>. Verlag Dr. Friedrich Pfeil, 2017.","ama":"Cremer S. Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern. <i>Rundgespräche Forum Ökologie</i>. 2017;46:105-116."},"ddc":["592"],"status":"public","year":"2017","language":[{"iso":"eng"}],"corr_author":"1","oa":1,"intvolume":"        46","publication":"Rundgespräche Forum Ökologie","volume":46,"day":"04","publisher":"Verlag Dr. Friedrich Pfeil","publication_identifier":{"issn":["2366-2875"]},"file":[{"file_id":"5175","access_level":"open_access","relation":"main_file","creator":"system","checksum":"4919baf9050415ca151fe22497379f78","content_type":"application/pdf","date_updated":"2020-07-14T12:46:32Z","file_name":"IST-2018-962-v1+1_044676698_07_Cremer__Invasive_Ameisen_in_Europa_...__BY-ND_.pdf","date_created":"2018-12-12T10:15:52Z","file_size":1711131}],"quality_controlled":"1","title":"Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern","author":[{"first_name":"Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia"}],"_id":"459","page":"105 - 116","date_created":"2018-12-11T11:46:35Z","file_date_updated":"2020-07-14T12:46:32Z"},{"oa":1,"intvolume":"        27","year":"2017","language":[{"iso":"eng"}],"day":"01","publication":"Chaos","volume":27,"quality_controlled":"1","title":"Transient behavior between multi-cell flow states in ferrofluidic Taylor-Couette flow","author":[{"id":"2EE67FDC-F248-11E8-B48F-1D18A9856A87","last_name":"Altmeyer","full_name":"Altmeyer, Sebastian","first_name":"Sebastian","orcid":"0000-0001-5964-0203"},{"first_name":"Younghae","last_name":"Do","full_name":"Do, Younghae"},{"first_name":"Soorok","full_name":"Ryu, Soorok","last_name":"Ryu"}],"article_type":"original","publisher":"AIP Publishing","publication_identifier":{"issn":["1054-1500"]},"scopus_import":"1","file":[{"date_updated":"2020-07-14T12:46:32Z","file_name":"2017_Chaos_Altmeyer.pdf","date_created":"2019-10-24T15:14:30Z","content_type":"application/pdf","file_size":7714020,"access_level":"open_access","file_id":"6970","creator":"dernst","relation":"main_file","checksum":"0731f9d416760c1062db258ca51f8bdc"}],"date_created":"2018-12-11T11:46:37Z","_id":"463","file_date_updated":"2020-07-14T12:46:32Z","has_accepted_license":"1","article_processing_charge":"No","department":[{"_id":"BjHo"}],"article_number":"113112","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2025-09-18T09:58:08Z","fulldoi":"https://doi.org/10.1063/1.5002771","publication_status":"published","issue":"11","publist_id":"7358","oa_version":"Published Version","external_id":{"isi":["000416827300016"]},"type":"journal_article","month":"11","abstract":[{"lang":"eng","text":"We investigate transient behaviors induced by magnetic fields on the dynamics of the flow of a ferrofluid in the gap between two concentric, independently rotating cylinders. Without applying any magnetic fields, we uncover emergence of flow states constituted by a combination of a localized spiral state (SPIl) in the top and bottom of the annulus and different multi-cell flow states (SPI2v, SPI3v) with toroidally closed vortices in the interior of the bulk (SPIl+2v = SPIl + SPI2v and SPIl+3v = SPIl + SPI3v). However, when a magnetic field is presented, we observe the transient behaviors between multi-cell states passing through two critical thresholds in a strength of an axial (transverse) magnetic field. Before the first critical threshold of a magnetic field strength, multi-stable states with different number of cells could be observed. After the first critical threshold, we find the transient behavior between the three- and two-cell flow states. For more strength of magnetic field or after the second critical threshold, we discover that multi-cell states are disappeared and a localized spiral state remains to be stimulated. The studied transient behavior could be understood by the investigation of various quantities including a modal kinetic energy, a mode amplitude of the radial velocity, wavenumber, angular momentum, and torque. In addition, the emergence of new flow states and the transient behavior between their states in ferrofluidic flows indicate that richer and potentially controllable dynamics through magnetic fields could be possible in ferrofluic flow."}],"status":"public","isi":1,"doi":"10.1063/1.5002771","date_published":"2017-11-01T00:00:00Z","citation":{"short":"S. Altmeyer, Y. Do, S. Ryu, Chaos 27 (2017).","ieee":"S. Altmeyer, Y. Do, and S. Ryu, “Transient behavior between multi-cell flow states in ferrofluidic Taylor-Couette flow,” <i>Chaos</i>, vol. 27, no. 11. AIP Publishing, 2017.","ama":"Altmeyer S, Do Y, Ryu S. Transient behavior between multi-cell flow states in ferrofluidic Taylor-Couette flow. <i>Chaos</i>. 2017;27(11). doi:<a href=\"https://doi.org/10.1063/1.5002771\">10.1063/1.5002771</a>","ista":"Altmeyer S, Do Y, Ryu S. 2017. Transient behavior between multi-cell flow states in ferrofluidic Taylor-Couette flow. Chaos. 27(11), 113112.","chicago":"Altmeyer, Sebastian, Younghae Do, and Soorok Ryu. “Transient Behavior between Multi-Cell Flow States in Ferrofluidic Taylor-Couette Flow.” <i>Chaos</i>. AIP Publishing, 2017. <a href=\"https://doi.org/10.1063/1.5002771\">https://doi.org/10.1063/1.5002771</a>.","mla":"Altmeyer, Sebastian, et al. “Transient Behavior between Multi-Cell Flow States in Ferrofluidic Taylor-Couette Flow.” <i>Chaos</i>, vol. 27, no. 11, 113112, AIP Publishing, 2017, doi:<a href=\"https://doi.org/10.1063/1.5002771\">10.1063/1.5002771</a>.","apa":"Altmeyer, S., Do, Y., &#38; Ryu, S. (2017). Transient behavior between multi-cell flow states in ferrofluidic Taylor-Couette flow. <i>Chaos</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/1.5002771\">https://doi.org/10.1063/1.5002771</a>"},"ddc":["530"]},{"day":"01","volume":36,"publication":"ACM Transactions on Graphics","oa":1,"intvolume":"        36","year":"2017","acknowledged_ssus":[{"_id":"ScienComp"}],"language":[{"iso":"eng"}],"date_created":"2018-12-11T11:46:39Z","_id":"470","file_date_updated":"2020-07-14T12:46:34Z","quality_controlled":"1","title":"Water wave packets","author":[{"orcid":"0000-0003-4330-8884","first_name":"Stefan","id":"44D6411A-F248-11E8-B48F-1D18A9856A87","full_name":"Jeschke, Stefan","last_name":"Jeschke"},{"orcid":"0000-0001-6646-5546","first_name":"Christopher J","last_name":"Wojtan","full_name":"Wojtan, Christopher J","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87"}],"article_type":"original","publisher":"ACM","publication_identifier":{"issn":["0730-0301"]},"scopus_import":"1","file":[{"file_id":"7359","access_level":"open_access","creator":"wojtan","relation":"main_file","checksum":"82a3b2bfeee4ddef16ecc21675d1a48a","content_type":"application/pdf","date_created":"2020-01-24T09:32:35Z","date_updated":"2020-07-14T12:46:34Z","file_name":"wavepackets_final.pdf","file_size":13131683}],"ec_funded":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-04-16T09:58:39Z","fulldoi":"https://doi.org/10.1145/3072959.3073678","publication_status":"published","issue":"4","has_accepted_license":"1","article_processing_charge":"Yes (in subscription journal)","department":[{"_id":"ChWo"}],"article_number":"103","project":[{"call_identifier":"H2020","_id":"2533E772-B435-11E9-9278-68D0E5697425","name":"Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large Scales","grant_number":"638176"}],"status":"public","doi":"10.1145/3072959.3073678","isi":1,"date_published":"2017-07-01T00:00:00Z","ddc":["006"],"citation":{"mla":"Jeschke, Stefan, and Chris Wojtan. “Water Wave Packets.” <i>ACM Transactions on Graphics</i>, vol. 36, no. 4, 103, ACM, 2017, doi:<a href=\"https://doi.org/10.1145/3072959.3073678\">10.1145/3072959.3073678</a>.","apa":"Jeschke, S., &#38; Wojtan, C. (2017). Water wave packets. <i>ACM Transactions on Graphics</i>. ACM. <a href=\"https://doi.org/10.1145/3072959.3073678\">https://doi.org/10.1145/3072959.3073678</a>","short":"S. Jeschke, C. Wojtan, ACM Transactions on Graphics 36 (2017).","ieee":"S. Jeschke and C. Wojtan, “Water wave packets,” <i>ACM Transactions on Graphics</i>, vol. 36, no. 4. ACM, 2017.","ama":"Jeschke S, Wojtan C. Water wave packets. <i>ACM Transactions on Graphics</i>. 2017;36(4). doi:<a href=\"https://doi.org/10.1145/3072959.3073678\">10.1145/3072959.3073678</a>","ista":"Jeschke S, Wojtan C. 2017. Water wave packets. ACM Transactions on Graphics. 36(4), 103.","chicago":"Jeschke, Stefan, and Chris Wojtan. “Water Wave Packets.” <i>ACM Transactions on Graphics</i>. ACM, 2017. <a href=\"https://doi.org/10.1145/3072959.3073678\">https://doi.org/10.1145/3072959.3073678</a>."},"publist_id":"7350","oa_version":"Published Version","external_id":{"isi":["000406432100071"]},"type":"journal_article","month":"07","abstract":[{"text":"This paper presents a method for simulating water surface waves as a displacement field on a 2D domain. Our method relies on Lagrangian particles that carry packets of water wave energy; each packet carries information about an entire group of wave trains, as opposed to only a single wave crest. Our approach is unconditionally stable and can simulate high resolution geometric details. This approach also presents a straightforward interface for artistic control, because it is essentially a particle system with intuitive parameters like wavelength and amplitude. Our implementation parallelizes well and runs in real time for moderately challenging scenarios.","lang":"eng"}]},{"_id":"471","date_created":"2018-12-11T11:46:39Z","publication_identifier":{"issn":["1529-3785"]},"publisher":"ACM","scopus_import":"1","title":"Faster statistical model checking for unbounded temporal properties","quality_controlled":"1","author":[{"full_name":"Daca, Przemyslaw","id":"49351290-F248-11E8-B48F-1D18A9856A87","last_name":"Daca","first_name":"Przemyslaw"},{"last_name":"Henzinger","full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","orcid":"0000−0002−2985−7724"},{"last_name":"Kretinsky","id":"44CEF464-F248-11E8-B48F-1D18A9856A87","full_name":"Kretinsky, Jan","first_name":"Jan","orcid":"0000-0002-8122-2881"},{"first_name":"Tatjana","orcid":"0000-0002-9041-0905","last_name":"Petrov","id":"3D5811FC-F248-11E8-B48F-1D18A9856A87","full_name":"Petrov, Tatjana"}],"publication":"ACM Transactions on Computational Logic","volume":18,"day":"01","arxiv":1,"year":"2017","corr_author":"1","language":[{"iso":"eng"}],"oa":1,"intvolume":"        18","date_published":"2017-05-01T00:00:00Z","citation":{"mla":"Daca, Przemyslaw, et al. “Faster Statistical Model Checking for Unbounded Temporal Properties.” <i>ACM Transactions on Computational Logic</i>, vol. 18, no. 2, 12, ACM, 2017, doi:<a href=\"https://doi.org/10.1145/3060139\">10.1145/3060139</a>.","apa":"Daca, P., Henzinger, T. A., Kretinsky, J., &#38; Petrov, T. (2017). Faster statistical model checking for unbounded temporal properties. <i>ACM Transactions on Computational Logic</i>. ACM. <a href=\"https://doi.org/10.1145/3060139\">https://doi.org/10.1145/3060139</a>","ista":"Daca P, Henzinger TA, Kretinsky J, Petrov T. 2017. Faster statistical model checking for unbounded temporal properties. ACM Transactions on Computational Logic. 18(2), 12.","chicago":"Daca, Przemyslaw, Thomas A Henzinger, Jan Kretinsky, and Tatjana Petrov. “Faster Statistical Model Checking for Unbounded Temporal Properties.” <i>ACM Transactions on Computational Logic</i>. ACM, 2017. <a href=\"https://doi.org/10.1145/3060139\">https://doi.org/10.1145/3060139</a>.","ama":"Daca P, Henzinger TA, Kretinsky J, Petrov T. Faster statistical model checking for unbounded temporal properties. <i>ACM Transactions on Computational Logic</i>. 2017;18(2). doi:<a href=\"https://doi.org/10.1145/3060139\">10.1145/3060139</a>","ieee":"P. Daca, T. A. Henzinger, J. Kretinsky, and T. Petrov, “Faster statistical model checking for unbounded temporal properties,” <i>ACM Transactions on Computational Logic</i>, vol. 18, no. 2. ACM, 2017.","short":"P. Daca, T.A. Henzinger, J. Kretinsky, T. Petrov, ACM Transactions on Computational Logic 18 (2017)."},"project":[{"grant_number":"267989","name":"Quantitative Reactive Modeling","call_identifier":"FP7","_id":"25EE3708-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","_id":"25F5A88A-B435-11E9-9278-68D0E5697425","grant_number":"S11402-N23","name":"Moderne Concurrency Paradigms"},{"grant_number":"Z211","name":"Formal methods for the design and analysis of complex systems","call_identifier":"FWF","_id":"25F42A32-B435-11E9-9278-68D0E5697425"},{"grant_number":"291734","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"status":"public","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1504.05739"}],"isi":1,"doi":"10.1145/3060139","month":"05","related_material":{"record":[{"id":"1234","status":"public","relation":"earlier_version"}]},"abstract":[{"lang":"eng","text":"We present a new algorithm for the statistical model checking of Markov chains with respect to unbounded temporal properties, including full linear temporal logic. The main idea is that we monitor each simulation run on the fly, in order to detect quickly if a bottom strongly connected component is entered with high probability, in which case the simulation run can be terminated early. As a result, our simulation runs are often much shorter than required by termination bounds that are computed a priori for a desired level of confidence on a large state space. In comparison to previous algorithms for statistical model checking our method is not only faster in many cases but also requires less information about the system, namely, only the minimum transition probability that occurs in the Markov chain. In addition, our method can be generalised to unbounded quantitative properties such as mean-payoff bounds. "}],"oa_version":"Submitted Version","publist_id":"7349","external_id":{"arxiv":["1504.05739"],"isi":["000405208400005"]},"type":"journal_article","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","ec_funded":1,"publication_status":"published","issue":"2","date_updated":"2025-09-22T09:21:16Z","fulldoi":"https://doi.org/10.1145/3060139","article_number":"12","article_processing_charge":"No","department":[{"_id":"ToHe"}]}]