[{"abstract":[{"lang":"eng","text":"Intellectual disability (ID) has an estimated prevalence of 2-3%. Due to its extreme heterogeneity, the genetic basis of ID remains elusive in many cases. Recently, whole exome sequencing (WES) studies revealed that a large proportion of sporadic cases are caused by de novo gene variants. To identify further genes involved in ID, we performed WES in 250 patients with unexplained ID and their unaffected parents and included exomes of 51 previously sequenced child-parents trios in the analysis. Exome analysis revealed de novo intragenic variants in SET domain-containing 5 (SETD5) in two patients. One patient carried a nonsense variant, and the other an 81 bp deletion located across a splice-donor site. Chromosomal microarray diagnostics further identified four de novo non-recurrent microdeletions encompassing SETD5. CRISPR/Cas9 mutation modelling of the two intragenic variants demonstrated nonsense-mediated decay of the resulting transcripts, pointing to a loss-of-function (LoF) and haploinsufficiency as the common disease-causing mechanism of intragenic SETD5 sequence variants and SETD5-containing microdeletions. In silico domain prediction of SETD5, a predicted SET domain-containing histone methyltransferase (HMT), substantiated the presence of a SET domain and identified a novel putative PHD domain, strengthening a functional link to well-known histone-modifying ID genes. All six patients presented with ID and certain facial dysmorphisms, suggesting that SETD5 sequence variants contribute substantially to the microdeletion 3p25.3 phenotype. The present report of two SETD5 LoF variants in 301 patients demonstrates a prevalence of 0.7% and thus SETD5 variants as a relatively frequent cause of ID."}],"publisher":"Nature Publishing Group","intvolume":"        23","publication":"European Journal of Human Genetics","date_published":"2015-06-15T00:00:00Z","quality_controlled":"1","article_processing_charge":"No","department":[{"_id":"GaNo"}],"volume":23,"type":"journal_article","author":[{"first_name":"Alma","full_name":"Kuechler, Alma","last_name":"Kuechler"},{"last_name":"Zink","full_name":"Zink, Alexander","first_name":"Alexander"},{"first_name":"Thomas","full_name":"Wieland, Thomas","last_name":"Wieland"},{"full_name":"Lüdecke, Hermann","first_name":"Hermann","last_name":"Lüdecke"},{"first_name":"Kirsten","full_name":"Cremer, Kirsten","last_name":"Cremer"},{"full_name":"Salviati, Leonardo","first_name":"Leonardo","last_name":"Salviati"},{"last_name":"Magini","first_name":"Pamela","full_name":"Magini, Pamela"},{"first_name":"Kimia","full_name":"Najafi, Kimia","last_name":"Najafi"},{"last_name":"Zweier","first_name":"Christiane","full_name":"Zweier, Christiane"},{"last_name":"Czeschik","first_name":"Johanna","full_name":"Czeschik, Johanna"},{"first_name":"Stefan","full_name":"Aretz, Stefan","last_name":"Aretz"},{"last_name":"Endele","first_name":"Sabine","full_name":"Endele, Sabine"},{"last_name":"Tamburrino","full_name":"Tamburrino, Federica","first_name":"Federica"},{"last_name":"Pinato","full_name":"Pinato, Claudia","first_name":"Claudia"},{"last_name":"Clementi","first_name":"Maurizio","full_name":"Clementi, Maurizio"},{"full_name":"Gundlach, Jasmin","first_name":"Jasmin","last_name":"Gundlach"},{"last_name":"Maylahn","first_name":"Carina","full_name":"Maylahn, Carina"},{"last_name":"Mazzanti","first_name":"Laura","full_name":"Mazzanti, Laura"},{"first_name":"Eva","full_name":"Wohlleber, Eva","last_name":"Wohlleber"},{"full_name":"Schwarzmayr, Thomas","first_name":"Thomas","last_name":"Schwarzmayr"},{"last_name":"Kariminejad","first_name":"Roxana","full_name":"Kariminejad, Roxana"},{"full_name":"Schlessinger, Avner","first_name":"Avner","last_name":"Schlessinger"},{"last_name":"Wieczorek","full_name":"Wieczorek, Dagmar","first_name":"Dagmar"},{"first_name":"Tim","full_name":"Strom, Tim","last_name":"Strom"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","last_name":"Novarino","first_name":"Gaia","full_name":"Novarino, Gaia"},{"first_name":"Hartmut","full_name":"Engels, Hartmut","last_name":"Engels"}],"date_updated":"2025-09-23T09:30:27Z","year":"2015","isi":1,"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795044/"}],"oa":1,"page":"753 - 760","external_id":{"isi":["000354474600013"],"pmid":["25138099"]},"doi":"10.1038/ejhg.2014.165","language":[{"iso":"eng"}],"status":"public","date_created":"2018-12-11T11:54:01Z","publist_id":"5324","month":"06","issue":"6","day":"15","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"ista":"Kuechler A, Zink A, Wieland T, Lüdecke H, Cremer K, Salviati L, Magini P, Najafi K, Zweier C, Czeschik J, Aretz S, Endele S, Tamburrino F, Pinato C, Clementi M, Gundlach J, Maylahn C, Mazzanti L, Wohlleber E, Schwarzmayr T, Kariminejad R, Schlessinger A, Wieczorek D, Strom T, Novarino G, Engels H. 2015. Loss-of-function variants of SETD5 cause intellectual disability and the core phenotype of microdeletion 3p25.3 syndrome. European Journal of Human Genetics. 23(6), 753–760.","chicago":"Kuechler, Alma, Alexander Zink, Thomas Wieland, Hermann Lüdecke, Kirsten Cremer, Leonardo Salviati, Pamela Magini, et al. “Loss-of-Function Variants of SETD5 Cause Intellectual Disability and the Core Phenotype of Microdeletion 3p25.3 Syndrome.” <i>European Journal of Human Genetics</i>. Nature Publishing Group, 2015. <a href=\"https://doi.org/10.1038/ejhg.2014.165\">https://doi.org/10.1038/ejhg.2014.165</a>.","ama":"Kuechler A, Zink A, Wieland T, et al. Loss-of-function variants of SETD5 cause intellectual disability and the core phenotype of microdeletion 3p25.3 syndrome. <i>European Journal of Human Genetics</i>. 2015;23(6):753-760. doi:<a href=\"https://doi.org/10.1038/ejhg.2014.165\">10.1038/ejhg.2014.165</a>","ieee":"A. Kuechler <i>et al.</i>, “Loss-of-function variants of SETD5 cause intellectual disability and the core phenotype of microdeletion 3p25.3 syndrome,” <i>European Journal of Human Genetics</i>, vol. 23, no. 6. Nature Publishing Group, pp. 753–760, 2015.","apa":"Kuechler, A., Zink, A., Wieland, T., Lüdecke, H., Cremer, K., Salviati, L., … Engels, H. (2015). Loss-of-function variants of SETD5 cause intellectual disability and the core phenotype of microdeletion 3p25.3 syndrome. <i>European Journal of Human Genetics</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ejhg.2014.165\">https://doi.org/10.1038/ejhg.2014.165</a>","short":"A. Kuechler, A. Zink, T. Wieland, H. Lüdecke, K. Cremer, L. Salviati, P. Magini, K. Najafi, C. Zweier, J. Czeschik, S. Aretz, S. Endele, F. Tamburrino, C. Pinato, M. Clementi, J. Gundlach, C. Maylahn, L. Mazzanti, E. Wohlleber, T. Schwarzmayr, R. Kariminejad, A. Schlessinger, D. Wieczorek, T. Strom, G. Novarino, H. Engels, European Journal of Human Genetics 23 (2015) 753–760.","mla":"Kuechler, Alma, et al. “Loss-of-Function Variants of SETD5 Cause Intellectual Disability and the Core Phenotype of Microdeletion 3p25.3 Syndrome.” <i>European Journal of Human Genetics</i>, vol. 23, no. 6, Nature Publishing Group, 2015, pp. 753–60, doi:<a href=\"https://doi.org/10.1038/ejhg.2014.165\">10.1038/ejhg.2014.165</a>."},"_id":"1789","fulldoi":"https://doi.org/10.1038/ejhg.2014.165","title":"Loss-of-function variants of SETD5 cause intellectual disability and the core phenotype of microdeletion 3p25.3 syndrome","oa_version":"Submitted Version","publication_status":"published","pmid":1},{"abstract":[{"lang":"eng","text":"We present a software platform for reconstructing and analyzing the growth of a plant root system from a time-series of 3D voxelized shapes. It aligns the shapes with each other, constructs a geometric graph representation together with the function that records the time of growth, and organizes the branches into a hierarchy that reflects the order of creation. The software includes the automatic computation of structural and dynamic traits for each root in the system enabling the quantification of growth on fine-scale. These are important advances in plant phenotyping with applications to the study of genetic and environmental influences on growth."}],"publisher":"Public Library of Science","intvolume":"        10","date_published":"2015-06-01T00:00:00Z","publication":"PLoS One","pubrep_id":"454","corr_author":"1","has_accepted_license":"1","ddc":["000"],"quality_controlled":"1","article_processing_charge":"No","department":[{"_id":"MaJö"},{"_id":"HeEd"}],"volume":10,"related_material":{"record":[{"relation":"research_data","id":"9737","status":"public"}]},"type":"journal_article","scopus_import":"1","year":"2015","date_updated":"2025-09-23T08:30:43Z","author":[{"first_name":"Olga","full_name":"Symonova, Olga","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2012-9947","last_name":"Symonova"},{"last_name":"Topp","first_name":"Christopher","full_name":"Topp, Christopher"},{"first_name":"Herbert","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner"}],"isi":1,"external_id":{"isi":["000356630900069"]},"oa":1,"language":[{"iso":"eng"}],"doi":"10.1371/journal.pone.0127657","date_created":"2018-12-11T11:54:02Z","publist_id":"5318","status":"public","file":[{"file_id":"5150","file_size":1850825,"creator":"system","checksum":"d20f26461ca575276ad3ed9ce4bfc787","content_type":"application/pdf","relation":"main_file","date_updated":"2020-07-14T12:45:16Z","access_level":"open_access","file_name":"IST-2016-454-v1+1_journal.pone.0127657.pdf","date_created":"2018-12-12T10:15:30Z"}],"month":"06","issue":"6","day":"01","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"ieee":"O. Symonova, C. Topp, and H. Edelsbrunner, “DynamicRoots: A software platform for the reconstruction and analysis of growing plant roots,” <i>PLoS One</i>, vol. 10, no. 6. Public Library of Science, 2015.","apa":"Symonova, O., Topp, C., &#38; Edelsbrunner, H. (2015). DynamicRoots: A software platform for the reconstruction and analysis of growing plant roots. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0127657\">https://doi.org/10.1371/journal.pone.0127657</a>","short":"O. Symonova, C. Topp, H. Edelsbrunner, PLoS One 10 (2015).","mla":"Symonova, Olga, et al. “DynamicRoots: A Software Platform for the Reconstruction and Analysis of Growing Plant Roots.” <i>PLoS One</i>, vol. 10, no. 6, e0127657, Public Library of Science, 2015, doi:<a href=\"https://doi.org/10.1371/journal.pone.0127657\">10.1371/journal.pone.0127657</a>.","ista":"Symonova O, Topp C, Edelsbrunner H. 2015. DynamicRoots: A software platform for the reconstruction and analysis of growing plant roots. PLoS One. 10(6), e0127657.","ama":"Symonova O, Topp C, Edelsbrunner H. DynamicRoots: A software platform for the reconstruction and analysis of growing plant roots. <i>PLoS One</i>. 2015;10(6). doi:<a href=\"https://doi.org/10.1371/journal.pone.0127657\">10.1371/journal.pone.0127657</a>","chicago":"Symonova, Olga, Christopher Topp, and Herbert Edelsbrunner. “DynamicRoots: A Software Platform for the Reconstruction and Analysis of Growing Plant Roots.” <i>PLoS One</i>. Public Library of Science, 2015. <a href=\"https://doi.org/10.1371/journal.pone.0127657\">https://doi.org/10.1371/journal.pone.0127657</a>."},"file_date_updated":"2020-07-14T12:45:16Z","article_number":"e0127657","fulldoi":"https://doi.org/10.1371/journal.pone.0127657","title":"DynamicRoots: A software platform for the reconstruction and analysis of growing plant roots","_id":"1793","oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_status":"published"},{"pmid":1,"publication_status":"published","oa_version":"None","fulldoi":"https://doi.org/10.1021/acs.nanolett.5b03962","title":"Ultrafast bidirectional charge transport and electron decoherence at molecule/surface interfaces: A comparison of gold, graphene, and graphene nanoribbon surfaces","_id":"17965","citation":{"apa":"Adak, O., Kladnik, G., Bavdek, G., Cossaro, A., Morgante, A., Cvetko, D., &#38; Venkataraman, L. (2015). Ultrafast bidirectional charge transport and electron decoherence at molecule/surface interfaces: A comparison of gold, graphene, and graphene nanoribbon surfaces. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.5b03962\">https://doi.org/10.1021/acs.nanolett.5b03962</a>","ieee":"O. Adak <i>et al.</i>, “Ultrafast bidirectional charge transport and electron decoherence at molecule/surface interfaces: A comparison of gold, graphene, and graphene nanoribbon surfaces,” <i>Nano Letters</i>, vol. 15, no. 12. American Chemical Society, pp. 8316–8321, 2015.","mla":"Adak, Olgun, et al. “Ultrafast Bidirectional Charge Transport and Electron Decoherence at Molecule/Surface Interfaces: A Comparison of Gold, Graphene, and Graphene Nanoribbon Surfaces.” <i>Nano Letters</i>, vol. 15, no. 12, American Chemical Society, 2015, pp. 8316–21, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b03962\">10.1021/acs.nanolett.5b03962</a>.","short":"O. Adak, G. Kladnik, G. Bavdek, A. Cossaro, A. Morgante, D. Cvetko, L. Venkataraman, Nano Letters 15 (2015) 8316–8321.","chicago":"Adak, Olgun, Gregor Kladnik, Gregor Bavdek, Albano Cossaro, Alberto Morgante, Dean Cvetko, and Latha Venkataraman. “Ultrafast Bidirectional Charge Transport and Electron Decoherence at Molecule/Surface Interfaces: A Comparison of Gold, Graphene, and Graphene Nanoribbon Surfaces.” <i>Nano Letters</i>. American Chemical Society, 2015. <a href=\"https://doi.org/10.1021/acs.nanolett.5b03962\">https://doi.org/10.1021/acs.nanolett.5b03962</a>.","ama":"Adak O, Kladnik G, Bavdek G, et al. Ultrafast bidirectional charge transport and electron decoherence at molecule/surface interfaces: A comparison of gold, graphene, and graphene nanoribbon surfaces. <i>Nano Letters</i>. 2015;15(12):8316-8321. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b03962\">10.1021/acs.nanolett.5b03962</a>","ista":"Adak O, Kladnik G, Bavdek G, Cossaro A, Morgante A, Cvetko D, Venkataraman L. 2015. Ultrafast bidirectional charge transport and electron decoherence at molecule/surface interfaces: A comparison of gold, graphene, and graphene nanoribbon surfaces. Nano Letters. 15(12), 8316–8321."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"17","issue":"12","month":"11","publication_identifier":{"eissn":["1530-6992"],"issn":["1530-6984"]},"date_created":"2024-09-09T09:40:21Z","status":"public","doi":"10.1021/acs.nanolett.5b03962","language":[{"iso":"eng"}],"article_type":"letter_note","page":"8316-8321","external_id":{"pmid":["26574713"]},"year":"2015","author":[{"full_name":"Adak, Olgun","first_name":"Olgun","last_name":"Adak"},{"full_name":"Kladnik, Gregor","first_name":"Gregor","last_name":"Kladnik"},{"first_name":"Gregor","full_name":"Bavdek, Gregor","last_name":"Bavdek"},{"first_name":"Albano","full_name":"Cossaro, Albano","last_name":"Cossaro"},{"last_name":"Morgante","full_name":"Morgante, Alberto","first_name":"Alberto"},{"full_name":"Cvetko, Dean","first_name":"Dean","last_name":"Cvetko"},{"orcid":"0000-0002-6957-6089","last_name":"Venkataraman","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","full_name":"Venkataraman, Latha","first_name":"Latha"}],"date_updated":"2024-12-18T10:22:39Z","scopus_import":"1","type":"journal_article","volume":15,"extern":"1","article_processing_charge":"No","quality_controlled":"1","date_published":"2015-11-17T00:00:00Z","publication":"Nano Letters","intvolume":"        15","publisher":"American Chemical Society","abstract":[{"text":"We investigate bidirectional femtosecond charge transfer dynamics using the core–hole clock implementation of resonant photoemission spectroscopy from 4,4′-bipyridine molecular layers on three different surfaces: Au(111), epitaxial graphene on Ni(111), and graphene nanoribbons. We show that the lowest unoccupied molecular orbital (LUMO) of the molecule drops partially below the Fermi level upon core–hole creation in all systems, opening an additional decay channel for the core–hole, involving electron donation from substrate to the molecule. Furthermore, using the core–hole clock method, we find that the bidirectional charge transfer time between the substrate and the molecule is fastest on Au(111), with a 2 fs time, then around 4 fs for epitaxial graphene and slowest with graphene nanoribbon surface, taking around 10 fs. Finally, we provide evidence for fast phase decoherence of the core-excited LUMO* electron through an interaction with the substrate providing the first observation of such a fast bidirectional charge transfer across an organic/graphene interface.","lang":"eng"}]},{"day":"20","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Strange M, Solomon GC, Venkataraman L, Campos LM. 2015. Reply to “Comment on ‘Breakdown of Interference Rules in Azulene, a Nonalternant Hydrocarbon’”. Nano Letters. 15(11), 7177–7178.","chicago":"Strange, Mikkel, Gemma C. Solomon, Latha Venkataraman, and Luis M. Campos. “Reply to ‘Comment on “Breakdown of Interference Rules in Azulene, a Nonalternant Hydrocarbon.”’” <i>Nano Letters</i>. American Chemical Society, 2015. <a href=\"https://doi.org/10.1021/acs.nanolett.5b04154\">https://doi.org/10.1021/acs.nanolett.5b04154</a>.","ama":"Strange M, Solomon GC, Venkataraman L, Campos LM. Reply to “Comment on ‘Breakdown of Interference Rules in Azulene, a Nonalternant Hydrocarbon.’” <i>Nano Letters</i>. 2015;15(11):7177-7178. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b04154\">10.1021/acs.nanolett.5b04154</a>","mla":"Strange, Mikkel, et al. “Reply to ‘Comment on “Breakdown of Interference Rules in Azulene, a Nonalternant Hydrocarbon.”’” <i>Nano Letters</i>, vol. 15, no. 11, American Chemical Society, 2015, pp. 7177–78, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b04154\">10.1021/acs.nanolett.5b04154</a>.","short":"M. Strange, G.C. Solomon, L. Venkataraman, L.M. Campos, Nano Letters 15 (2015) 7177–7178.","ieee":"M. Strange, G. C. Solomon, L. Venkataraman, and L. M. Campos, “Reply to ‘Comment on “Breakdown of Interference Rules in Azulene, a Nonalternant Hydrocarbon,”’” <i>Nano Letters</i>, vol. 15, no. 11. American Chemical Society, pp. 7177–7178, 2015.","apa":"Strange, M., Solomon, G. C., Venkataraman, L., &#38; Campos, L. M. (2015). Reply to “Comment on ‘Breakdown of Interference Rules in Azulene, a Nonalternant Hydrocarbon.’” <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.5b04154\">https://doi.org/10.1021/acs.nanolett.5b04154</a>"},"fulldoi":"https://doi.org/10.1021/acs.nanolett.5b04154","title":"Reply to “Comment on ‘Breakdown of Interference Rules in Azulene, a Nonalternant Hydrocarbon’”","_id":"17966","oa_version":"None","publication_status":"published","pmid":1,"OA_type":"closed access","external_id":{"pmid":["24745894"]},"page":"7177-7178","article_type":"letter_note","doi":"10.1021/acs.nanolett.5b04154","language":[{"iso":"eng"}],"date_created":"2024-09-09T09:41:17Z","publication_identifier":{"issn":["1530-6984"],"eissn":["1530-6992"]},"status":"public","month":"10","issue":"11","article_processing_charge":"No","extern":"1","volume":15,"scopus_import":"1","type":"journal_article","year":"2015","author":[{"first_name":"Mikkel","full_name":"Strange, Mikkel","last_name":"Strange"},{"last_name":"Solomon","first_name":"Gemma C.","full_name":"Solomon, Gemma C."},{"first_name":"Latha","full_name":"Venkataraman, Latha","orcid":"0000-0002-6957-6089","last_name":"Venkataraman","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf"},{"last_name":"Campos","full_name":"Campos, Luis M.","first_name":"Luis M."}],"date_updated":"2024-12-18T10:28:04Z","publisher":"American Chemical Society","intvolume":"        15","date_published":"2015-10-20T00:00:00Z","publication":"Nano Letters","quality_controlled":"1"},{"page":"5888-5896","external_id":{"pmid":["26642992"]},"doi":"10.1021/acs.jctc.5b00823","language":[{"iso":"eng"}],"article_type":"original","date_created":"2024-09-09T09:42:20Z","publication_identifier":{"eissn":["1549-9626"],"issn":["1549-9618"]},"status":"public","issue":"12","month":"11","day":"03","citation":{"apa":"Ding, W., Koepf, M., Koenigsmann, C., Batra, A., Venkataraman, L., Negre, C. F. A., … Batista, V. S. (2015). Computational design of intrinsic molecular rectifiers based on asymmetric functionalization of N-Phenylbenzamide. <i>Journal of Chemical Theory and Computation</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.jctc.5b00823\">https://doi.org/10.1021/acs.jctc.5b00823</a>","ieee":"W. Ding <i>et al.</i>, “Computational design of intrinsic molecular rectifiers based on asymmetric functionalization of N-Phenylbenzamide,” <i>Journal of Chemical Theory and Computation</i>, vol. 11, no. 12. American Chemical Society, pp. 5888–5896, 2015.","short":"W. Ding, M. Koepf, C. Koenigsmann, A. Batra, L. Venkataraman, C.F.A. Negre, G.W. Brudvig, R.H. Crabtree, C.A. Schmuttenmaer, V.S. Batista, Journal of Chemical Theory and Computation 11 (2015) 5888–5896.","mla":"Ding, Wendu, et al. “Computational Design of Intrinsic Molecular Rectifiers Based on Asymmetric Functionalization of N-Phenylbenzamide.” <i>Journal of Chemical Theory and Computation</i>, vol. 11, no. 12, American Chemical Society, 2015, pp. 5888–96, doi:<a href=\"https://doi.org/10.1021/acs.jctc.5b00823\">10.1021/acs.jctc.5b00823</a>.","ama":"Ding W, Koepf M, Koenigsmann C, et al. Computational design of intrinsic molecular rectifiers based on asymmetric functionalization of N-Phenylbenzamide. <i>Journal of Chemical Theory and Computation</i>. 2015;11(12):5888-5896. doi:<a href=\"https://doi.org/10.1021/acs.jctc.5b00823\">10.1021/acs.jctc.5b00823</a>","chicago":"Ding, Wendu, Matthieu Koepf, Christopher Koenigsmann, Arunabh Batra, Latha Venkataraman, Christian F. A. Negre, Gary W. Brudvig, Robert H. Crabtree, Charles A. Schmuttenmaer, and Victor S. Batista. “Computational Design of Intrinsic Molecular Rectifiers Based on Asymmetric Functionalization of N-Phenylbenzamide.” <i>Journal of Chemical Theory and Computation</i>. American Chemical Society, 2015. <a href=\"https://doi.org/10.1021/acs.jctc.5b00823\">https://doi.org/10.1021/acs.jctc.5b00823</a>.","ista":"Ding W, Koepf M, Koenigsmann C, Batra A, Venkataraman L, Negre CFA, Brudvig GW, Crabtree RH, Schmuttenmaer CA, Batista VS. 2015. Computational design of intrinsic molecular rectifiers based on asymmetric functionalization of N-Phenylbenzamide. Journal of Chemical Theory and Computation. 11(12), 5888–5896."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Computational design of intrinsic molecular rectifiers based on asymmetric functionalization of N-Phenylbenzamide","fulldoi":"https://doi.org/10.1021/acs.jctc.5b00823","_id":"17967","pmid":1,"OA_type":"closed access","publication_status":"published","oa_version":"None","abstract":[{"lang":"eng","text":"We report a systematic computational search of molecular frameworks for intrinsic rectification of electron transport. The screening of molecular rectifiers includes 52 molecules and conformers spanning over 9 series of structural motifs. N-Phenylbenzamide is found to be a promising framework with both suitable conductance and rectification properties. A targeted screening performed on 30 additional derivatives and conformers of N-phenylbenzamide yielded enhanced rectification based on asymmetric functionalization. We demonstrate that electron-donating substituent groups that maintain an asymmetric distribution of charge in the dominant transport channel (e.g., HOMO) enhance rectification by raising the channel closer to the Fermi level. These findings are particularly valuable for the design of molecular assemblies that could ensure directionality of electron transport in a wide range of applications, from molecular electronics to catalytic reactions."}],"intvolume":"        11","publisher":"American Chemical Society","date_published":"2015-11-03T00:00:00Z","publication":"Journal of Chemical Theory and Computation","quality_controlled":"1","extern":"1","article_processing_charge":"No","scopus_import":"1","type":"journal_article","volume":11,"year":"2015","author":[{"first_name":"Wendu","full_name":"Ding, Wendu","last_name":"Ding"},{"last_name":"Koepf","full_name":"Koepf, Matthieu","first_name":"Matthieu"},{"full_name":"Koenigsmann, Christopher","first_name":"Christopher","last_name":"Koenigsmann"},{"last_name":"Batra","full_name":"Batra, Arunabh","first_name":"Arunabh"},{"id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","orcid":"0000-0002-6957-6089","last_name":"Venkataraman","first_name":"Latha","full_name":"Venkataraman, Latha"},{"last_name":"Negre","full_name":"Negre, Christian F. A.","first_name":"Christian F. A."},{"last_name":"Brudvig","full_name":"Brudvig, Gary W.","first_name":"Gary W."},{"full_name":"Crabtree, Robert H.","first_name":"Robert H.","last_name":"Crabtree"},{"full_name":"Schmuttenmaer, Charles A.","first_name":"Charles A.","last_name":"Schmuttenmaer"},{"full_name":"Batista, Victor S.","first_name":"Victor S.","last_name":"Batista"}],"date_updated":"2024-12-18T10:33:40Z"},{"publication":"Journal of the American Chemical Society","date_published":"2015-09-16T00:00:00Z","quality_controlled":"1","abstract":[{"text":"While the electrical conductivity of bulk-scale group 14 materials such as diamond carbon, silicon, and germanium is well understood, there is a gap in knowledge regarding the conductivity of these materials at the nano and molecular scales. Filling this gap is important because integrated circuits have shrunk so far that their active regions, which rely so heavily on silicon and germanium, begin to resemble ornate molecules rather than extended solids. Here we unveil a new approach for synthesizing atomically discrete wires of germanium and present the first conductance measurements of molecular germanium using a scanning tunneling microscope-based break-junction (STM-BJ) technique. Our findings show that germanium and silicon wires are nearly identical in conductivity at the molecular scale, and that both are much more conductive than aliphatic carbon. We demonstrate that the strong donor ability of C–Ge σ-bonds can be used to raise the energy of the anchor lone pair and increase conductance. Furthermore, the oligogermane wires behave as conductance switches that function through stereoelectronic logic. These devices can be trained to operate with a higher switching factor by repeatedly compressing and elongating the molecular junction.","lang":"eng"}],"intvolume":"       137","publisher":"American Chemical Society","type":"journal_article","scopus_import":"1","volume":137,"date_updated":"2024-12-18T11:24:37Z","author":[{"last_name":"Su","first_name":"Timothy A.","full_name":"Su, Timothy A."},{"last_name":"Li","full_name":"Li, Haixing","first_name":"Haixing"},{"full_name":"Zhang, Vivian","first_name":"Vivian","last_name":"Zhang"},{"first_name":"Madhav","full_name":"Neupane, Madhav","last_name":"Neupane"},{"last_name":"Batra","first_name":"Arunabh","full_name":"Batra, Arunabh"},{"last_name":"Klausen","first_name":"Rebekka S.","full_name":"Klausen, Rebekka S."},{"last_name":"Kumar","first_name":"Bharat","full_name":"Kumar, Bharat"},{"last_name":"Steigerwald","full_name":"Steigerwald, Michael L.","first_name":"Michael L."},{"full_name":"Venkataraman, Latha","first_name":"Latha","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","last_name":"Venkataraman","orcid":"0000-0002-6957-6089"},{"last_name":"Nuckolls","first_name":"Colin","full_name":"Nuckolls, Colin"}],"year":"2015","extern":"1","article_processing_charge":"No","status":"public","publication_identifier":{"issn":["0002-7863"],"eissn":["1520-5126"]},"date_created":"2024-09-09T09:43:25Z","issue":"38","month":"09","external_id":{"pmid":["26373928"]},"page":"12400-12405","language":[{"iso":"eng"}],"doi":"10.1021/jacs.5b08155","article_type":"original","_id":"17968","title":"Single-molecule conductance in atomically precise Germanium wires","fulldoi":"https://doi.org/10.1021/jacs.5b08155","OA_type":"closed access","pmid":1,"publication_status":"published","oa_version":"None","day":"16","citation":{"ieee":"T. A. Su <i>et al.</i>, “Single-molecule conductance in atomically precise Germanium wires,” <i>Journal of the American Chemical Society</i>, vol. 137, no. 38. American Chemical Society, pp. 12400–12405, 2015.","apa":"Su, T. A., Li, H., Zhang, V., Neupane, M., Batra, A., Klausen, R. S., … Nuckolls, C. (2015). Single-molecule conductance in atomically precise Germanium wires. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/jacs.5b08155\">https://doi.org/10.1021/jacs.5b08155</a>","short":"T.A. Su, H. Li, V. Zhang, M. Neupane, A. Batra, R.S. Klausen, B. Kumar, M.L. Steigerwald, L. Venkataraman, C. Nuckolls, Journal of the American Chemical Society 137 (2015) 12400–12405.","mla":"Su, Timothy A., et al. “Single-Molecule Conductance in Atomically Precise Germanium Wires.” <i>Journal of the American Chemical Society</i>, vol. 137, no. 38, American Chemical Society, 2015, pp. 12400–05, doi:<a href=\"https://doi.org/10.1021/jacs.5b08155\">10.1021/jacs.5b08155</a>.","ista":"Su TA, Li H, Zhang V, Neupane M, Batra A, Klausen RS, Kumar B, Steigerwald ML, Venkataraman L, Nuckolls C. 2015. Single-molecule conductance in atomically precise Germanium wires. Journal of the American Chemical Society. 137(38), 12400–12405.","chicago":"Su, Timothy A., Haixing Li, Vivian Zhang, Madhav Neupane, Arunabh Batra, Rebekka S. Klausen, Bharat Kumar, Michael L. Steigerwald, Latha Venkataraman, and Colin Nuckolls. “Single-Molecule Conductance in Atomically Precise Germanium Wires.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2015. <a href=\"https://doi.org/10.1021/jacs.5b08155\">https://doi.org/10.1021/jacs.5b08155</a>.","ama":"Su TA, Li H, Zhang V, et al. Single-molecule conductance in atomically precise Germanium wires. <i>Journal of the American Chemical Society</i>. 2015;137(38):12400-12405. doi:<a href=\"https://doi.org/10.1021/jacs.5b08155\">10.1021/jacs.5b08155</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"quality_controlled":"1","publication":"Nano Letters","OA_place":"repository","date_published":"2015-06-12T00:00:00Z","intvolume":"        15","publisher":"American Chemical Society","abstract":[{"lang":"eng","text":"Recent experiments have shown that transport properties of molecular-scale devices can be reversibly altered by the surrounding solvent. Here, we use a combination of first-principles calculations and experiment to explain this change in transport properties through a shift in the local electrostatic potential at the junction caused by nearby conducting and solvent molecules chemically bound to the electrodes. This effect is found to alter the conductance of 4,4′-bipyridine-gold junctions by more than 50%. Moreover, we develop a general electrostatic model that quantitatively relates the conductance and dipoles associated with the bound solvent and conducting molecules. Our work shows that solvent-induced effects can be used to control charge and energy transport at molecular-scale interfaces."}],"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1410.1439","open_access":"1"}],"date_updated":"2024-12-18T11:28:49Z","author":[{"first_name":"Michele","full_name":"Kotiuga, Michele","last_name":"Kotiuga"},{"last_name":"Darancet","full_name":"Darancet, Pierre","first_name":"Pierre"},{"last_name":"Arroyo","full_name":"Arroyo, Carlos R.","first_name":"Carlos R."},{"first_name":"Latha","full_name":"Venkataraman, Latha","orcid":"0000-0002-6957-6089","last_name":"Venkataraman","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf"},{"full_name":"Neaton, Jeffrey B.","first_name":"Jeffrey B.","last_name":"Neaton"}],"year":"2015","type":"journal_article","scopus_import":"1","volume":15,"arxiv":1,"article_processing_charge":"No","extern":"1","issue":"7","month":"06","status":"public","publication_identifier":{"eissn":["1530-6992"],"issn":["1530-6984"]},"date_created":"2024-09-09T09:44:13Z","language":[{"iso":"eng"}],"article_type":"letter_note","doi":"10.1021/acs.nanolett.5b00990","oa":1,"page":"4498-4503","external_id":{"arxiv":["1410.1439"]},"publication_status":"published","OA_type":"green","oa_version":"Preprint","_id":"17969","fulldoi":"https://doi.org/10.1021/acs.nanolett.5b00990","title":"Adsorption-induced solvent-based electrostatic gating of charge transport through molecular junctions","citation":{"apa":"Kotiuga, M., Darancet, P., Arroyo, C. R., Venkataraman, L., &#38; Neaton, J. B. (2015). Adsorption-induced solvent-based electrostatic gating of charge transport through molecular junctions. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.5b00990\">https://doi.org/10.1021/acs.nanolett.5b00990</a>","ieee":"M. Kotiuga, P. Darancet, C. R. Arroyo, L. Venkataraman, and J. B. Neaton, “Adsorption-induced solvent-based electrostatic gating of charge transport through molecular junctions,” <i>Nano Letters</i>, vol. 15, no. 7. American Chemical Society, pp. 4498–4503, 2015.","short":"M. Kotiuga, P. Darancet, C.R. Arroyo, L. Venkataraman, J.B. Neaton, Nano Letters 15 (2015) 4498–4503.","mla":"Kotiuga, Michele, et al. “Adsorption-Induced Solvent-Based Electrostatic Gating of Charge Transport through Molecular Junctions.” <i>Nano Letters</i>, vol. 15, no. 7, American Chemical Society, 2015, pp. 4498–503, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b00990\">10.1021/acs.nanolett.5b00990</a>.","ama":"Kotiuga M, Darancet P, Arroyo CR, Venkataraman L, Neaton JB. Adsorption-induced solvent-based electrostatic gating of charge transport through molecular junctions. <i>Nano Letters</i>. 2015;15(7):4498-4503. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b00990\">10.1021/acs.nanolett.5b00990</a>","chicago":"Kotiuga, Michele, Pierre Darancet, Carlos R. Arroyo, Latha Venkataraman, and Jeffrey B. Neaton. “Adsorption-Induced Solvent-Based Electrostatic Gating of Charge Transport through Molecular Junctions.” <i>Nano Letters</i>. American Chemical Society, 2015. <a href=\"https://doi.org/10.1021/acs.nanolett.5b00990\">https://doi.org/10.1021/acs.nanolett.5b00990</a>.","ista":"Kotiuga M, Darancet P, Arroyo CR, Venkataraman L, Neaton JB. 2015. Adsorption-induced solvent-based electrostatic gating of charge transport through molecular junctions. Nano Letters. 15(7), 4498–4503."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"12"},{"volume":15,"scopus_import":"1","type":"journal_article","author":[{"last_name":"Adak","first_name":"Olgun","full_name":"Adak, Olgun"},{"first_name":"Ethan","full_name":"Rosenthal, Ethan","last_name":"Rosenthal"},{"first_name":"Jeffery","full_name":"Meisner, Jeffery","last_name":"Meisner"},{"full_name":"Andrade, Erick F.","first_name":"Erick F.","last_name":"Andrade"},{"full_name":"Pasupathy, Abhay N.","first_name":"Abhay N.","last_name":"Pasupathy"},{"last_name":"Nuckolls","full_name":"Nuckolls, Colin","first_name":"Colin"},{"full_name":"Hybertsen, Mark S.","first_name":"Mark S.","last_name":"Hybertsen"},{"full_name":"Venkataraman, Latha","first_name":"Latha","orcid":"0000-0002-6957-6089","last_name":"Venkataraman","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf"}],"date_updated":"2024-12-18T11:32:55Z","year":"2015","extern":"1","article_processing_charge":"No","publication":"Nano Letters","date_published":"2015-05-05T00:00:00Z","quality_controlled":"1","abstract":[{"lang":"eng","text":"Charge transport properties of metal–molecule interfaces depend strongly on the character of molecule–electrode interactions. Although through-bond coupled systems have attracted the most attention, through-space coupling is important in molecular systems when, for example, through-bond coupling is suppressed due to quantum interference effects. To date, a probe that clearly distinguishes these two types of coupling has not yet been demonstrated. Here, we investigate the origin of flicker noise in single molecule junctions and demonstrate how the character of the molecule–electrode coupling influences the flicker noise behavior of single molecule junctions. Importantly, we find that flicker noise shows a power law dependence on conductance in all junctions studied with an exponent that can distinguish through-space and through-bond coupling. Our results provide a new and powerful tool for probing and understanding coupling at the metal-molecule interface."}],"publisher":"American Chemical Society","intvolume":"        15","_id":"17970","fulldoi":"https://doi.org/10.1021/acs.nanolett.5b01270","title":"Flicker noise as a probe of electronic interaction at metal–single molecule interfaces","oa_version":"None","pmid":1,"publication_status":"published","OA_type":"closed access","day":"05","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Adak O, Rosenthal E, Meisner J, Andrade EF, Pasupathy AN, Nuckolls C, Hybertsen MS, Venkataraman L. 2015. Flicker noise as a probe of electronic interaction at metal–single molecule interfaces. Nano Letters. 15(6), 4143–4149.","ama":"Adak O, Rosenthal E, Meisner J, et al. Flicker noise as a probe of electronic interaction at metal–single molecule interfaces. <i>Nano Letters</i>. 2015;15(6):4143-4149. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b01270\">10.1021/acs.nanolett.5b01270</a>","chicago":"Adak, Olgun, Ethan Rosenthal, Jeffery Meisner, Erick F. Andrade, Abhay N. Pasupathy, Colin Nuckolls, Mark S. Hybertsen, and Latha Venkataraman. “Flicker Noise as a Probe of Electronic Interaction at Metal–Single Molecule Interfaces.” <i>Nano Letters</i>. American Chemical Society, 2015. <a href=\"https://doi.org/10.1021/acs.nanolett.5b01270\">https://doi.org/10.1021/acs.nanolett.5b01270</a>.","mla":"Adak, Olgun, et al. “Flicker Noise as a Probe of Electronic Interaction at Metal–Single Molecule Interfaces.” <i>Nano Letters</i>, vol. 15, no. 6, American Chemical Society, 2015, pp. 4143–49, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b01270\">10.1021/acs.nanolett.5b01270</a>.","short":"O. Adak, E. Rosenthal, J. Meisner, E.F. Andrade, A.N. Pasupathy, C. Nuckolls, M.S. Hybertsen, L. Venkataraman, Nano Letters 15 (2015) 4143–4149.","ieee":"O. Adak <i>et al.</i>, “Flicker noise as a probe of electronic interaction at metal–single molecule interfaces,” <i>Nano Letters</i>, vol. 15, no. 6. American Chemical Society, pp. 4143–4149, 2015.","apa":"Adak, O., Rosenthal, E., Meisner, J., Andrade, E. F., Pasupathy, A. N., Nuckolls, C., … Venkataraman, L. (2015). Flicker noise as a probe of electronic interaction at metal–single molecule interfaces. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.5b01270\">https://doi.org/10.1021/acs.nanolett.5b01270</a>"},"status":"public","publication_identifier":{"issn":["1530-6984"],"eissn":["1530-6992"]},"date_created":"2024-09-09T09:45:50Z","month":"05","issue":"6","page":"4143-4149","external_id":{"pmid":["25942441"]},"language":[{"iso":"eng"}],"article_type":"letter_note","doi":"10.1021/acs.nanolett.5b01270"},{"oa":1,"page":"3716-3722","external_id":{"arxiv":["1504.00242"]},"doi":"10.1021/acs.nanolett.5b01195","language":[{"iso":"eng"}],"article_type":"letter_note","status":"public","date_created":"2024-09-09T10:02:07Z","publication_identifier":{"issn":["1530-6984"],"eissn":["1530-6992"]},"issue":"6","month":"05","day":"28","citation":{"ieee":"O. Adak, R. Korytár, A. Y. Joe, F. Evers, and L. Venkataraman, “Impact of electrode density of states on transport through pyridine-linked single molecule junctions,” <i>Nano Letters</i>, vol. 15, no. 6. American Chemical Society, pp. 3716–3722, 2015.","apa":"Adak, O., Korytár, R., Joe, A. Y., Evers, F., &#38; Venkataraman, L. (2015). Impact of electrode density of states on transport through pyridine-linked single molecule junctions. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.5b01195\">https://doi.org/10.1021/acs.nanolett.5b01195</a>","short":"O. Adak, R. Korytár, A.Y. Joe, F. Evers, L. Venkataraman, Nano Letters 15 (2015) 3716–3722.","mla":"Adak, Olgun, et al. “Impact of Electrode Density of States on Transport through Pyridine-Linked Single Molecule Junctions.” <i>Nano Letters</i>, vol. 15, no. 6, American Chemical Society, 2015, pp. 3716–22, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b01195\">10.1021/acs.nanolett.5b01195</a>.","ista":"Adak O, Korytár R, Joe AY, Evers F, Venkataraman L. 2015. Impact of electrode density of states on transport through pyridine-linked single molecule junctions. Nano Letters. 15(6), 3716–3722.","chicago":"Adak, Olgun, Richard Korytár, Andrew Y. Joe, Ferdinand Evers, and Latha Venkataraman. “Impact of Electrode Density of States on Transport through Pyridine-Linked Single Molecule Junctions.” <i>Nano Letters</i>. American Chemical Society, 2015. <a href=\"https://doi.org/10.1021/acs.nanolett.5b01195\">https://doi.org/10.1021/acs.nanolett.5b01195</a>.","ama":"Adak O, Korytár R, Joe AY, Evers F, Venkataraman L. Impact of electrode density of states on transport through pyridine-linked single molecule junctions. <i>Nano Letters</i>. 2015;15(6):3716-3722. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5b01195\">10.1021/acs.nanolett.5b01195</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"17971","fulldoi":"https://doi.org/10.1021/acs.nanolett.5b01195","title":"Impact of electrode density of states on transport through pyridine-linked single molecule junctions","publication_status":"published","OA_type":"green","oa_version":"Preprint","abstract":[{"lang":"eng","text":"We study the impact of electrode band structure on transport through single-molecule junctions by measuring the conductance of pyridine-based molecules using Ag and Au electrodes. Our experiments are carried out using the scanning tunneling microscope based break-junction technique and are supported by density functional theory based calculations. We find from both experiments and calculations that the coupling of the dominant transport orbital to the metal is stronger for Au-based junctions when compared with Ag-based junctions. We attribute this difference to relativistic effects, which result in an enhanced density of d-states at the Fermi energy for Au compared with Ag. We further show that the alignment of the conducting orbital relative to the Fermi level does not follow the work function difference between two metals and is different for conjugated and saturated systems. We thus demonstrate that the details of the molecular level alignment and electronic coupling in metal–organic interfaces do not follow simple rules but are rather the consequence of subtle local interactions."}],"intvolume":"        15","publisher":"American Chemical Society","publication":"Nano Letters","OA_place":"repository","date_published":"2015-05-28T00:00:00Z","quality_controlled":"1","arxiv":1,"extern":"1","article_processing_charge":"No","type":"journal_article","scopus_import":"1","volume":15,"main_file_link":[{"url":"https://arxiv.org/abs/1504.00242","open_access":"1"}],"date_updated":"2024-12-18T11:37:35Z","author":[{"last_name":"Adak","first_name":"Olgun","full_name":"Adak, Olgun"},{"first_name":"Richard","full_name":"Korytár, Richard","last_name":"Korytár"},{"first_name":"Andrew Y.","full_name":"Joe, Andrew Y.","last_name":"Joe"},{"full_name":"Evers, Ferdinand","first_name":"Ferdinand","last_name":"Evers"},{"id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","orcid":"0000-0002-6957-6089","last_name":"Venkataraman","full_name":"Venkataraman, Latha","first_name":"Latha"}],"year":"2015"},{"month":"06","issue":"6","publication_identifier":{"eissn":["1748-3395"],"issn":["1748-3387"]},"date_created":"2024-09-09T10:03:23Z","status":"public","doi":"10.1038/nnano.2015.97","article_type":"letter_note","language":[{"iso":"eng"}],"page":"522-527","external_id":{"pmid":["26005998"]},"oa_version":"None","pmid":1,"publication_status":"published","OA_type":"closed access","fulldoi":"https://doi.org/10.1038/nnano.2015.97","title":"Single-molecule diodes with high rectification ratios through environmental control","_id":"17972","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ieee":"B. Capozzi <i>et al.</i>, “Single-molecule diodes with high rectification ratios through environmental control,” <i>Nature Nanotechnology</i>, vol. 10, no. 6. Springer Nature, pp. 522–527, 2015.","apa":"Capozzi, B., Xia, J., Adak, O., Dell, E. J., Liu, Z.-F., Taylor, J. C., … Venkataraman, L. (2015). Single-molecule diodes with high rectification ratios through environmental control. <i>Nature Nanotechnology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nnano.2015.97\">https://doi.org/10.1038/nnano.2015.97</a>","mla":"Capozzi, Brian, et al. “Single-Molecule Diodes with High Rectification Ratios through Environmental Control.” <i>Nature Nanotechnology</i>, vol. 10, no. 6, Springer Nature, 2015, pp. 522–27, doi:<a href=\"https://doi.org/10.1038/nnano.2015.97\">10.1038/nnano.2015.97</a>.","short":"B. Capozzi, J. Xia, O. Adak, E.J. Dell, Z.-F. Liu, J.C. Taylor, J.B. Neaton, L.M. Campos, L. Venkataraman, Nature Nanotechnology 10 (2015) 522–527.","ista":"Capozzi B, Xia J, Adak O, Dell EJ, Liu Z-F, Taylor JC, Neaton JB, Campos LM, Venkataraman L. 2015. Single-molecule diodes with high rectification ratios through environmental control. Nature Nanotechnology. 10(6), 522–527.","ama":"Capozzi B, Xia J, Adak O, et al. Single-molecule diodes with high rectification ratios through environmental control. <i>Nature Nanotechnology</i>. 2015;10(6):522-527. doi:<a href=\"https://doi.org/10.1038/nnano.2015.97\">10.1038/nnano.2015.97</a>","chicago":"Capozzi, Brian, Jianlong Xia, Olgun Adak, Emma J. Dell, Zhen-Fei Liu, Jeffrey C. Taylor, Jeffrey B. Neaton, Luis M. Campos, and Latha Venkataraman. “Single-Molecule Diodes with High Rectification Ratios through Environmental Control.” <i>Nature Nanotechnology</i>. Springer Nature, 2015. <a href=\"https://doi.org/10.1038/nnano.2015.97\">https://doi.org/10.1038/nnano.2015.97</a>."},"day":"01","quality_controlled":"1","date_published":"2015-06-01T00:00:00Z","publication":"Nature Nanotechnology","publisher":"Springer Nature","intvolume":"        10","abstract":[{"text":"Molecular electronics aims to miniaturize electronic devices by using subnanometre-scale active components1,2,3. A single-molecule diode, a circuit element that directs current flow4, was first proposed more than 40 years ago5 and consisted of an asymmetric molecule comprising a donor–bridge–acceptor architecture to mimic a semiconductor p–n junction. Several single-molecule diodes have since been realized in junctions featuring asymmetric molecular backbones6,7,8, molecule–electrode linkers9 or electrode materials10. Despite these advances, molecular diodes have had limited potential for applications due to their low conductance, low rectification ratios, extreme sensitivity to the junction structure and high operating voltages7,8,9,11,12. Here, we demonstrate a powerful approach to induce current rectification in symmetric single-molecule junctions using two electrodes of the same metal, but breaking symmetry by exposing considerably different electrode areas to an ionic solution. This allows us to control the junction's electrostatic environment in an asymmetric fashion by simply changing the bias polarity. With this method, we reliably and reproducibly achieve rectification ratios in excess of 200 at voltages as low as 370 mV using a symmetric oligomer of thiophene-1,1-dioxide13,14. By taking advantage of the changes in the junction environment induced by the presence of an ionic solution, this method provides a general route for tuning nonlinear nanoscale device phenomena, which could potentially be applied in systems beyond single-molecule junctions.","lang":"eng"}],"year":"2015","date_updated":"2024-12-18T12:03:16Z","author":[{"first_name":"Brian","full_name":"Capozzi, Brian","last_name":"Capozzi"},{"full_name":"Xia, Jianlong","first_name":"Jianlong","last_name":"Xia"},{"full_name":"Adak, Olgun","first_name":"Olgun","last_name":"Adak"},{"last_name":"Dell","full_name":"Dell, Emma J.","first_name":"Emma J."},{"last_name":"Liu","full_name":"Liu, Zhen-Fei","first_name":"Zhen-Fei"},{"full_name":"Taylor, Jeffrey C.","first_name":"Jeffrey C.","last_name":"Taylor"},{"first_name":"Jeffrey B.","full_name":"Neaton, Jeffrey B.","last_name":"Neaton"},{"full_name":"Campos, Luis M.","first_name":"Luis M.","last_name":"Campos"},{"full_name":"Venkataraman, Latha","first_name":"Latha","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","last_name":"Venkataraman","orcid":"0000-0002-6957-6089"}],"volume":10,"scopus_import":"1","type":"journal_article","extern":"1","article_processing_charge":"No"},{"oa_version":"None","publication_status":"published","pmid":1,"OA_type":"closed access","_id":"17973","fulldoi":"https://doi.org/10.1021/ja512523r","title":"Electric field breakdown in single molecule junctions","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"H. Li, T.A. Su, V. Zhang, M.L. Steigerwald, C. Nuckolls, L. Venkataraman, Journal of the American Chemical Society 137 (2015) 5028–5033.","mla":"Li, Haixing, et al. “Electric Field Breakdown in Single Molecule Junctions.” <i>Journal of the American Chemical Society</i>, vol. 137, no. 15, American Chemical Society, 2015, pp. 5028–33, doi:<a href=\"https://doi.org/10.1021/ja512523r\">10.1021/ja512523r</a>.","apa":"Li, H., Su, T. A., Zhang, V., Steigerwald, M. L., Nuckolls, C., &#38; Venkataraman, L. (2015). Electric field breakdown in single molecule junctions. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/ja512523r\">https://doi.org/10.1021/ja512523r</a>","ieee":"H. Li, T. A. Su, V. Zhang, M. L. Steigerwald, C. Nuckolls, and L. Venkataraman, “Electric field breakdown in single molecule junctions,” <i>Journal of the American Chemical Society</i>, vol. 137, no. 15. American Chemical Society, pp. 5028–5033, 2015.","ama":"Li H, Su TA, Zhang V, Steigerwald ML, Nuckolls C, Venkataraman L. Electric field breakdown in single molecule junctions. <i>Journal of the American Chemical Society</i>. 2015;137(15):5028-5033. doi:<a href=\"https://doi.org/10.1021/ja512523r\">10.1021/ja512523r</a>","chicago":"Li, Haixing, Timothy A. Su, Vivian Zhang, Michael L. Steigerwald, Colin Nuckolls, and Latha Venkataraman. “Electric Field Breakdown in Single Molecule Junctions.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2015. <a href=\"https://doi.org/10.1021/ja512523r\">https://doi.org/10.1021/ja512523r</a>.","ista":"Li H, Su TA, Zhang V, Steigerwald ML, Nuckolls C, Venkataraman L. 2015. Electric field breakdown in single molecule junctions. Journal of the American Chemical Society. 137(15), 5028–5033."},"day":"12","month":"02","issue":"15","status":"public","publication_identifier":{"issn":["0002-7863"],"eissn":["1520-5126"]},"date_created":"2024-09-09T10:04:02Z","article_type":"original","language":[{"iso":"eng"}],"doi":"10.1021/ja512523r","external_id":{"pmid":["25675085"]},"page":"5028-5033","author":[{"last_name":"Li","full_name":"Li, Haixing","first_name":"Haixing"},{"full_name":"Su, Timothy A.","first_name":"Timothy A.","last_name":"Su"},{"last_name":"Zhang","first_name":"Vivian","full_name":"Zhang, Vivian"},{"full_name":"Steigerwald, Michael L.","first_name":"Michael L.","last_name":"Steigerwald"},{"first_name":"Colin","full_name":"Nuckolls, Colin","last_name":"Nuckolls"},{"id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","orcid":"0000-0002-6957-6089","last_name":"Venkataraman","full_name":"Venkataraman, Latha","first_name":"Latha"}],"date_updated":"2024-12-18T12:10:06Z","year":"2015","volume":137,"scopus_import":"1","type":"journal_article","article_processing_charge":"No","extern":"1","quality_controlled":"1","publication":"Journal of the American Chemical Society","date_published":"2015-02-12T00:00:00Z","publisher":"American Chemical Society","intvolume":"       137","abstract":[{"text":"Here we study the stability and rupture of molecular junctions under high voltage bias at the single molecule/single bond level using the scanning tunneling microscope-based break-junction technique. We synthesize carbon-, silicon-, and germanium-based molecular wires terminated by aurophilic linker groups and study how the molecular backbone and linker group affect the probability of voltage-induced junction rupture. First, we find that junctions formed with covalent S–Au bonds are robust under high voltage and their rupture does not demonstrate bias dependence within our bias range. In contrast, junctions formed through donor–acceptor bonds rupture more frequently, and their rupture probability demonstrates a strong bias dependence. Moreover, we find that the junction rupture probability increases significantly above ∼1 V in junctions formed from methylthiol-terminated disilanes and digermanes, indicating a voltage-induced rupture of individual Si–Si and Ge–Ge bonds. Finally, we compare the rupture probabilities of the thiol-terminated silane derivatives containing Si–Si, Si–C, and Si–O bonds and find that Si–C backbones have higher probabilities of sustaining the highest voltage. These results establish a new method for studying electric field breakdown phenomena at the single molecule level.","lang":"eng"}]},{"publication_identifier":{"issn":["0306-0012"],"eissn":["1460-4744"]},"date_created":"2024-09-09T10:53:55Z","status":"public","month":"01","issue":"4","external_id":{"pmid":["25636152"]},"page":"842-844","language":[{"iso":"eng"}],"article_type":"letter_note","doi":"10.1039/c5cs90010g","fulldoi":"https://doi.org/10.1039/c5cs90010g","title":"Molecular wires","_id":"17974","oa_version":"None","publication_status":"published","pmid":1,"OA_type":"closed access","day":"30","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"apa":"Guldi, D. M., Nishihara, H., &#38; Venkataraman, L. (2015). Molecular wires. <i>Chemical Society Reviews</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/c5cs90010g\">https://doi.org/10.1039/c5cs90010g</a>","ieee":"D. M. Guldi, H. Nishihara, and L. Venkataraman, “Molecular wires,” <i>Chemical Society Reviews</i>, vol. 44, no. 4. Royal Society of Chemistry, pp. 842–844, 2015.","short":"D.M. Guldi, H. Nishihara, L. Venkataraman, Chemical Society Reviews 44 (2015) 842–844.","mla":"Guldi, Dirk M., et al. “Molecular Wires.” <i>Chemical Society Reviews</i>, vol. 44, no. 4, Royal Society of Chemistry, 2015, pp. 842–44, doi:<a href=\"https://doi.org/10.1039/c5cs90010g\">10.1039/c5cs90010g</a>.","ama":"Guldi DM, Nishihara H, Venkataraman L. Molecular wires. <i>Chemical Society Reviews</i>. 2015;44(4):842-844. doi:<a href=\"https://doi.org/10.1039/c5cs90010g\">10.1039/c5cs90010g</a>","chicago":"Guldi, Dirk M., Hiroshi Nishihara, and Latha Venkataraman. “Molecular Wires.” <i>Chemical Society Reviews</i>. Royal Society of Chemistry, 2015. <a href=\"https://doi.org/10.1039/c5cs90010g\">https://doi.org/10.1039/c5cs90010g</a>.","ista":"Guldi DM, Nishihara H, Venkataraman L. 2015. Molecular wires. Chemical Society Reviews. 44(4), 842–844."},"date_published":"2015-01-30T00:00:00Z","publication":"Chemical Society Reviews","quality_controlled":"1","abstract":[{"text":"Guest editors Dirk M. Guldi, Hiroshi Nishihara and Latha Venkataraman introduce the Molecular Wires issue of \"Chemical Society Reviews\".","lang":"eng"}],"publisher":"Royal Society of Chemistry","intvolume":"        44","volume":44,"type":"journal_article","scopus_import":"1","year":"2015","date_updated":"2025-01-02T13:26:36Z","author":[{"last_name":"Guldi","full_name":"Guldi, Dirk M.","first_name":"Dirk M."},{"first_name":"Hiroshi","full_name":"Nishihara, Hiroshi","last_name":"Nishihara"},{"full_name":"Venkataraman, Latha","first_name":"Latha","last_name":"Venkataraman","orcid":"0000-0002-6957-6089","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf"}],"article_processing_charge":"No","extern":"1"},{"abstract":[{"lang":"eng","text":"A new intersection between reaction chemistry and electronic circuitry is emerging from the ultraminiaturization of electronic devices. Over decades chemists have developed a nuanced understanding of stereoelectronics to establish how the electronic properties of molecules relate to their conformation; the recent advent of single-molecule break-junction techniques provides the means to alter this conformation with a level of control previously unimagined. Here we unite these ideas by demonstrating the first single-molecule switch that operates through a stereoelectronic effect. We demonstrate this behaviour in permethyloligosilanes with methylthiomethyl electrode linkers. The strong σ conjugation in the oligosilane backbone couples the stereoelectronic properties of the sulfur–methylene σ bonds that terminate the molecule. Theoretical calculations support the existence of three distinct dihedral conformations that differ drastically in their electronic character. We can shift between these three species by simply lengthening or compressing the molecular junction, and, in doing so, we can switch conductance digitally between two states."}],"publisher":"Springer Nature","intvolume":"         7","date_published":"2015-02-16T00:00:00Z","publication":"Nature Chemistry","quality_controlled":"1","extern":"1","article_processing_charge":"No","volume":7,"type":"journal_article","scopus_import":"1","year":"2015","date_updated":"2025-01-02T13:28:51Z","author":[{"full_name":"Su, Timothy A.","first_name":"Timothy A.","last_name":"Su"},{"full_name":"Li, Haixing","first_name":"Haixing","last_name":"Li"},{"last_name":"Steigerwald","full_name":"Steigerwald, Michael L.","first_name":"Michael L."},{"last_name":"Venkataraman","orcid":"0000-0002-6957-6089","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","full_name":"Venkataraman, Latha","first_name":"Latha"},{"first_name":"Colin","full_name":"Nuckolls, Colin","last_name":"Nuckolls"}],"page":"215-220","external_id":{"pmid":["25698330"]},"doi":"10.1038/nchem.2180","language":[{"iso":"eng"}],"article_type":"original","publication_identifier":{"eissn":["1755-4349"],"issn":["1755-4330"]},"date_created":"2024-09-09T10:54:59Z","status":"public","month":"02","issue":"3","day":"16","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Su TA, Li H, Steigerwald ML, Venkataraman L, Nuckolls C. Stereoelectronic switching in single-molecule junctions. <i>Nature Chemistry</i>. 2015;7(3):215-220. doi:<a href=\"https://doi.org/10.1038/nchem.2180\">10.1038/nchem.2180</a>","chicago":"Su, Timothy A., Haixing Li, Michael L. Steigerwald, Latha Venkataraman, and Colin Nuckolls. “Stereoelectronic Switching in Single-Molecule Junctions.” <i>Nature Chemistry</i>. Springer Nature, 2015. <a href=\"https://doi.org/10.1038/nchem.2180\">https://doi.org/10.1038/nchem.2180</a>.","ista":"Su TA, Li H, Steigerwald ML, Venkataraman L, Nuckolls C. 2015. Stereoelectronic switching in single-molecule junctions. Nature Chemistry. 7(3), 215–220.","apa":"Su, T. A., Li, H., Steigerwald, M. L., Venkataraman, L., &#38; Nuckolls, C. (2015). Stereoelectronic switching in single-molecule junctions. <i>Nature Chemistry</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nchem.2180\">https://doi.org/10.1038/nchem.2180</a>","ieee":"T. A. Su, H. Li, M. L. Steigerwald, L. Venkataraman, and C. Nuckolls, “Stereoelectronic switching in single-molecule junctions,” <i>Nature Chemistry</i>, vol. 7, no. 3. Springer Nature, pp. 215–220, 2015.","short":"T.A. Su, H. Li, M.L. Steigerwald, L. Venkataraman, C. Nuckolls, Nature Chemistry 7 (2015) 215–220.","mla":"Su, Timothy A., et al. “Stereoelectronic Switching in Single-Molecule Junctions.” <i>Nature Chemistry</i>, vol. 7, no. 3, Springer Nature, 2015, pp. 215–20, doi:<a href=\"https://doi.org/10.1038/nchem.2180\">10.1038/nchem.2180</a>."},"title":"Stereoelectronic switching in single-molecule junctions","fulldoi":"https://doi.org/10.1038/nchem.2180","_id":"17975","oa_version":"None","publication_status":"published","OA_type":"closed access","pmid":1},{"article_processing_charge":"No","extern":"1","date_updated":"2025-01-02T13:35:46Z","author":[{"full_name":"Dell, Emma J.","first_name":"Emma J.","last_name":"Dell"},{"first_name":"Brian","full_name":"Capozzi, Brian","last_name":"Capozzi"},{"first_name":"Jianlong","full_name":"Xia, Jianlong","last_name":"Xia"},{"full_name":"Venkataraman, Latha","first_name":"Latha","orcid":"0000-0002-6957-6089","last_name":"Venkataraman","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf"},{"first_name":"Luis M.","full_name":"Campos, Luis M.","last_name":"Campos"}],"year":"2015","scopus_import":"1","type":"journal_article","volume":7,"intvolume":"         7","publisher":"Springer Nature","abstract":[{"text":"To develop advanced materials for electronic devices, it is of utmost importance to design organic building blocks with tunable functionality and to study their properties at the molecular level. For organic electronic and photovoltaic applications, the ability to vary the nature of charge carriers and so create either electron donors or acceptors is critical. Here we demonstrate that charge carriers in single-molecule junctions can be tuned within a family of molecules that contain electron-deficient thiophene-1,1-dioxide (TDO) building blocks. Oligomers of TDO were designed to increase electron affinity and maintain delocalized frontier orbitals while significantly decreasing the transport gap. Through thermopower measurements we show that the dominant charge carriers change from holes to electrons as the number of TDO units is increased. This results in a unique system in which the charge carrier depends on the backbone length, and provides a new means to tune p- and n-type transport in organic materials.","lang":"eng"}],"quality_controlled":"1","publication":"Nature Chemistry","date_published":"2015-02-02T00:00:00Z","citation":{"ieee":"E. J. Dell, B. Capozzi, J. Xia, L. Venkataraman, and L. M. Campos, “Molecular length dictates the nature of charge carriers in single-molecule junctions of oxidized oligothiophenes,” <i>Nature Chemistry</i>, vol. 7, no. 3. Springer Nature, pp. 209–214, 2015.","apa":"Dell, E. J., Capozzi, B., Xia, J., Venkataraman, L., &#38; Campos, L. M. (2015). Molecular length dictates the nature of charge carriers in single-molecule junctions of oxidized oligothiophenes. <i>Nature Chemistry</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nchem.2160\">https://doi.org/10.1038/nchem.2160</a>","short":"E.J. Dell, B. Capozzi, J. Xia, L. Venkataraman, L.M. Campos, Nature Chemistry 7 (2015) 209–214.","mla":"Dell, Emma J., et al. “Molecular Length Dictates the Nature of Charge Carriers in Single-Molecule Junctions of Oxidized Oligothiophenes.” <i>Nature Chemistry</i>, vol. 7, no. 3, Springer Nature, 2015, pp. 209–14, doi:<a href=\"https://doi.org/10.1038/nchem.2160\">10.1038/nchem.2160</a>.","ista":"Dell EJ, Capozzi B, Xia J, Venkataraman L, Campos LM. 2015. Molecular length dictates the nature of charge carriers in single-molecule junctions of oxidized oligothiophenes. Nature Chemistry. 7(3), 209–214.","chicago":"Dell, Emma J., Brian Capozzi, Jianlong Xia, Latha Venkataraman, and Luis M. Campos. “Molecular Length Dictates the Nature of Charge Carriers in Single-Molecule Junctions of Oxidized Oligothiophenes.” <i>Nature Chemistry</i>. Springer Nature, 2015. <a href=\"https://doi.org/10.1038/nchem.2160\">https://doi.org/10.1038/nchem.2160</a>.","ama":"Dell EJ, Capozzi B, Xia J, Venkataraman L, Campos LM. Molecular length dictates the nature of charge carriers in single-molecule junctions of oxidized oligothiophenes. <i>Nature Chemistry</i>. 2015;7(3):209-214. doi:<a href=\"https://doi.org/10.1038/nchem.2160\">10.1038/nchem.2160</a>"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"02","pmid":1,"OA_type":"closed access","publication_status":"published","oa_version":"None","_id":"17976","fulldoi":"https://doi.org/10.1038/nchem.2160","title":"Molecular length dictates the nature of charge carriers in single-molecule junctions of oxidized oligothiophenes","language":[{"iso":"eng"}],"article_type":"original","doi":"10.1038/nchem.2160","page":"209-214","external_id":{"pmid":["25698329"]},"issue":"3","month":"02","status":"public","date_created":"2024-09-09T10:55:42Z","publication_identifier":{"issn":["1755-4330"],"eissn":["1755-4349"]}},{"publication":"Nature Neuroscience","OA_place":"repository","date_published":"2015-07-01T00:00:00Z","quality_controlled":"1","abstract":[{"text":"Noncoding variants in the human MIR137 gene locus increase schizophrenia risk with genome-wide significance. However, the functional consequence of these risk alleles is unknown. Here we examined induced human neurons harboring the minor alleles of four disease-associated single nucleotide polymorphisms in MIR137. We observed increased MIR137 levels compared to those in major allele–carrying cells. microRNA-137 gain of function caused downregulation of the presynaptic target genes complexin-1 (Cplx1), Nsf and synaptotagmin-1 (Syt1), leading to impaired vesicle release. In vivo, miR-137 gain of function resulted in changes in synaptic vesicle pool distribution, impaired induction of mossy fiber long-term potentiation and deficits in hippocampus-dependent learning and memory. By sequestering endogenous miR-137, we were able to ameliorate the synaptic phenotypes. Moreover, reinstatement of Syt1 expression partially restored synaptic plasticity, demonstrating the importance of Syt1 as a miR-137 target. Our data provide new insight into the mechanism by which miR-137 dysregulation can impair synaptic plasticity in the hippocampus.","lang":"eng"}],"intvolume":"        18","publisher":"Springer Nature","scopus_import":"1","type":"journal_article","volume":18,"related_material":{"link":[{"url":"https://doi.org/10.1038/nn0816-1115c","relation":"erratum"}]},"main_file_link":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4506960/","open_access":"1"}],"date_updated":"2026-05-18T12:29:48Z","author":[{"id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","last_name":"Siegert","orcid":"0000-0001-8635-0877","full_name":"Siegert, Sandra","first_name":"Sandra"},{"last_name":"Seo","full_name":"Seo, Jinsoo","first_name":"Jinsoo"},{"first_name":"Ester","full_name":"Kwon, Ester","last_name":"Kwon"},{"first_name":"Andrii","full_name":"Rudenko, Andrii","last_name":"Rudenko"},{"last_name":"Cho","first_name":"Sukhee","full_name":"Cho, Sukhee"},{"last_name":"Wang","full_name":"Wang, Wenyuan","first_name":"Wenyuan"},{"last_name":"Flood","first_name":"Zachary","full_name":"Flood, Zachary"},{"full_name":"Martorell, Anthony","first_name":"Anthony","last_name":"Martorell"},{"full_name":"Ericsson, Maria","first_name":"Maria","last_name":"Ericsson"},{"last_name":"Mungenast","full_name":"Mungenast, Alison","first_name":"Alison"},{"full_name":"Tsai, Lihuei","first_name":"Lihuei","last_name":"Tsai"}],"year":"2015","article_processing_charge":"No","extern":"1","acknowledgement":"S.S. was supported by a Human Frontier Science Program (HFSP) long-term postdoctoral fellowship and a Swiss National Science Foundation fellowship for prospective researchers. E.J.K. was supported by a Simons Foundation Postdoctoral Fellowship. A.R. was supported by a NARSAD Young Investigator Award. This work was supported by a Seed Grant from the Simons Center for the Social Brain and US National Institutes of Health grant RO1 MH 091115 to L.-H.T.","status":"public","publist_id":"5308","date_created":"2018-12-11T11:54:05Z","publication_identifier":{"issn":["1097-6256"],"eissn":["1546-1726"]},"month":"07","oa":1,"page":"1008 - 1016","external_id":{"pmid":[" 26005852"]},"language":[{"iso":"eng"}],"article_type":"original","doi":"10.1038/nn.4023","_id":"1802","fulldoi":"https://doi.org/10.1038/nn.4023","title":"The schizophrenia risk gene product miR-137 alters presynaptic plasticity","pmid":1,"publication_status":"published","OA_type":"green","oa_version":"Accepted Version","day":"01","citation":{"ista":"Siegert S, Seo J, Kwon E, Rudenko A, Cho S, Wang W, Flood Z, Martorell A, Ericsson M, Mungenast A, Tsai L. 2015. The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nature Neuroscience. 18, 1008–1016.","ama":"Siegert S, Seo J, Kwon E, et al. The schizophrenia risk gene product miR-137 alters presynaptic plasticity. <i>Nature Neuroscience</i>. 2015;18:1008-1016. doi:<a href=\"https://doi.org/10.1038/nn.4023\">10.1038/nn.4023</a>","chicago":"Siegert, Sandra, Jinsoo Seo, Ester Kwon, Andrii Rudenko, Sukhee Cho, Wenyuan Wang, Zachary Flood, et al. “The Schizophrenia Risk Gene Product MiR-137 Alters Presynaptic Plasticity.” <i>Nature Neuroscience</i>. Springer Nature, 2015. <a href=\"https://doi.org/10.1038/nn.4023\">https://doi.org/10.1038/nn.4023</a>.","short":"S. Siegert, J. Seo, E. Kwon, A. Rudenko, S. Cho, W. Wang, Z. Flood, A. Martorell, M. Ericsson, A. Mungenast, L. Tsai, Nature Neuroscience 18 (2015) 1008–1016.","mla":"Siegert, Sandra, et al. “The Schizophrenia Risk Gene Product MiR-137 Alters Presynaptic Plasticity.” <i>Nature Neuroscience</i>, vol. 18, Springer Nature, 2015, pp. 1008–16, doi:<a href=\"https://doi.org/10.1038/nn.4023\">10.1038/nn.4023</a>.","ieee":"S. Siegert <i>et al.</i>, “The schizophrenia risk gene product miR-137 alters presynaptic plasticity,” <i>Nature Neuroscience</i>, vol. 18. Springer Nature, pp. 1008–1016, 2015.","apa":"Siegert, S., Seo, J., Kwon, E., Rudenko, A., Cho, S., Wang, W., … Tsai, L. (2015). The schizophrenia risk gene product miR-137 alters presynaptic plasticity. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nn.4023\">https://doi.org/10.1038/nn.4023</a>"},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"page":"7291 - 7296","abstract":[{"text":"Repeated stress has been suggested to underlie learning and memory deficits via the basolateral amygdala (BLA) and the hippocampus; however, the functional contribution of BLA inputs to the hippocampus and their molecular repercussions are not well understood. Here we show that repeated stress is accompanied by generation of the Cdk5 (cyclin-dependent kinase 5)-activator p25, up-regulation and phosphorylation of glucocorticoid receptors, increased HDAC2 expression, and reduced expression of memoryrelated genes in the hippocampus. A combination of optogenetic and pharmacosynthetic approaches shows that BLA activation is both necessary and sufficient for stress-associated molecular changes and memory impairments. Furthermore, we show that this effect relies on direct glutamatergic projections from the BLA to the dorsal hippocampus. Finally, we show that p25 generation is necessary for the stress-induced memory dysfunction. Taken together, our data provide a neural circuit model for stress-induced hippocampal memory deficits through BLA activity-dependent p25 generation.","lang":"eng"}],"doi":"10.1073/pnas.1415845112","publisher":"National Academy of Sciences","intvolume":"       112","date_published":"2015-06-09T00:00:00Z","date_created":"2018-12-11T11:54:06Z","publist_id":"5307","status":"public","publication":"PNAS","month":"06","quality_controlled":0,"issue":"23","acknowledgement":"AG047661; NIH; Schweizerische Nationalfonds zur Förderung der Wissenschaftlichen Forschung\nNS051874; NIH; Schweizerische Nationalfonds zur Förderung der Wissenschaftlichen Forschung\nSNSF; Schweizerische Nationalfonds zur Förderung der Wissenschaftlichen Forschung","day":"09","extern":1,"citation":{"ista":"Rei D, Mason X, Seo J, Gräff J, Rudenko A, Wang J, Rueda R, Siegert S, Cho S, Canter R, Mungenast A, Deisseroth K, Tsai L. 2015. Basolateral amygdala bidirectionally modulates stress induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. PNAS. 112(23), 7291–7296.","ama":"Rei D, Mason X, Seo J, et al. Basolateral amygdala bidirectionally modulates stress induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. <i>PNAS</i>. 2015;112(23):7291-7296. doi:<a href=\"https://doi.org/10.1073/pnas.1415845112\">10.1073/pnas.1415845112</a>","chicago":"Rei, Damien, Xenos Mason, Jinsoo Seo, Johannes Gräff, Andrii Rudenko, Jùn Wang, Richard Rueda, et al. “Basolateral Amygdala Bidirectionally Modulates Stress Induced Hippocampal Learning and Memory Deficits through a P25/Cdk5-Dependent Pathway.” <i>PNAS</i>. National Academy of Sciences, 2015. <a href=\"https://doi.org/10.1073/pnas.1415845112\">https://doi.org/10.1073/pnas.1415845112</a>.","mla":"Rei, Damien, et al. “Basolateral Amygdala Bidirectionally Modulates Stress Induced Hippocampal Learning and Memory Deficits through a P25/Cdk5-Dependent Pathway.” <i>PNAS</i>, vol. 112, no. 23, National Academy of Sciences, 2015, pp. 7291–96, doi:<a href=\"https://doi.org/10.1073/pnas.1415845112\">10.1073/pnas.1415845112</a>.","short":"D. Rei, X. Mason, J. Seo, J. Gräff, A. Rudenko, J. Wang, R. Rueda, S. Siegert, S. Cho, R. Canter, A. Mungenast, K. Deisseroth, L. Tsai, PNAS 112 (2015) 7291–7296.","ieee":"D. Rei <i>et al.</i>, “Basolateral amygdala bidirectionally modulates stress induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway,” <i>PNAS</i>, vol. 112, no. 23. National Academy of Sciences, pp. 7291–7296, 2015.","apa":"Rei, D., Mason, X., Seo, J., Gräff, J., Rudenko, A., Wang, J., … Tsai, L. (2015). Basolateral amygdala bidirectionally modulates stress induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1415845112\">https://doi.org/10.1073/pnas.1415845112</a>"},"volume":112,"fulldoi":"https://doi.org/10.1073/pnas.1415845112","title":"Basolateral amygdala bidirectionally modulates stress induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway","_id":"1803","type":"journal_article","year":"2015","date_updated":"2021-01-12T06:53:18Z","author":[{"last_name":"Rei","first_name":"Damien","full_name":"Rei, Damien"},{"full_name":"Mason, Xenos","first_name":"Xenos","last_name":"Mason"},{"last_name":"Seo","first_name":"Jinsoo","full_name":"Seo, Jinsoo"},{"full_name":"Gräff, Johannes","first_name":"Johannes","last_name":"Gräff"},{"last_name":"Rudenko","first_name":"Andrii","full_name":"Rudenko, Andrii"},{"full_name":"Wang, Jùn","first_name":"Jùn","last_name":"Wang"},{"full_name":"Rueda, Richard","first_name":"Richard","last_name":"Rueda"},{"orcid":"0000-0001-8635-0877","last_name":"Siegert","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","first_name":"Sandra","full_name":"Sandra Siegert"},{"first_name":"Sukhee","full_name":"Cho, Sukhee","last_name":"Cho"},{"last_name":"Canter","full_name":"Canter, Rebecca G","first_name":"Rebecca"},{"last_name":"Mungenast","full_name":"Mungenast, Alison E","first_name":"Alison"},{"first_name":"Karl","full_name":"Deisseroth, Karl A","last_name":"Deisseroth"},{"full_name":"Tsai, Lihuei","first_name":"Lihuei","last_name":"Tsai"}],"publication_status":"published"},{"month":"06","file":[{"checksum":"7716f582f8c9d82d8f2bf80bf896b440","file_size":2449723,"creator":"system","file_id":"5280","date_created":"2018-12-12T10:17:26Z","file_name":"IST-2016-450-v1+1_srep10781.pdf","access_level":"open_access","relation":"main_file","date_updated":"2020-07-14T12:45:16Z","content_type":"application/pdf"}],"date_created":"2018-12-11T11:54:06Z","publist_id":"5306","status":"public","language":[{"iso":"eng"}],"doi":"10.1038/srep10781","external_id":{"isi":["000356150200001"]},"oa":1,"publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","fulldoi":"https://doi.org/10.1038/srep10781","title":"Transition to turbulence in Taylor-Couette ferrofluidic flow","article_number":"10781","_id":"1804","citation":{"apa":"Altmeyer, S., Do, Y., &#38; Lai, Y. (2015). Transition to turbulence in Taylor-Couette ferrofluidic flow. <i>Scientific Reports</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/srep10781\">https://doi.org/10.1038/srep10781</a>","ieee":"S. Altmeyer, Y. Do, and Y. Lai, “Transition to turbulence in Taylor-Couette ferrofluidic flow,” <i>Scientific Reports</i>, vol. 5. Nature Publishing Group, 2015.","short":"S. Altmeyer, Y. Do, Y. Lai, Scientific Reports 5 (2015).","mla":"Altmeyer, Sebastian, et al. “Transition to Turbulence in Taylor-Couette Ferrofluidic Flow.” <i>Scientific Reports</i>, vol. 5, 10781, Nature Publishing Group, 2015, doi:<a href=\"https://doi.org/10.1038/srep10781\">10.1038/srep10781</a>.","chicago":"Altmeyer, Sebastian, Younghae Do, and Ying Lai. “Transition to Turbulence in Taylor-Couette Ferrofluidic Flow.” <i>Scientific Reports</i>. Nature Publishing Group, 2015. <a href=\"https://doi.org/10.1038/srep10781\">https://doi.org/10.1038/srep10781</a>.","ama":"Altmeyer S, Do Y, Lai Y. Transition to turbulence in Taylor-Couette ferrofluidic flow. <i>Scientific Reports</i>. 2015;5. doi:<a href=\"https://doi.org/10.1038/srep10781\">10.1038/srep10781</a>","ista":"Altmeyer S, Do Y, Lai Y. 2015. Transition to turbulence in Taylor-Couette ferrofluidic flow. Scientific Reports. 5, 10781."},"file_date_updated":"2020-07-14T12:45:16Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","day":"12","ddc":["530"],"quality_controlled":"1","corr_author":"1","has_accepted_license":"1","date_published":"2015-06-12T00:00:00Z","pubrep_id":"450","publication":"Scientific Reports","intvolume":"         5","publisher":"Nature Publishing Group","abstract":[{"lang":"eng","text":"It is known that in classical fluids turbulence typically occurs at high Reynolds numbers. But can turbulence occur at low Reynolds numbers? Here we investigate the transition to turbulence in the classic Taylor-Couette system in which the rotating fluids are manufactured ferrofluids with magnetized nanoparticles embedded in liquid carriers. We find that, in the presence of a magnetic field transverse to the symmetry axis of the system, turbulence can occur at Reynolds numbers that are at least one order of magnitude smaller than those in conventional fluids. This is established by extensive computational ferrohydrodynamics through a detailed investigation of transitions in the flow structure, and characterization of behaviors of physical quantities such as the energy, the wave number, and the angular momentum through the bifurcations. A finding is that, as the magnetic field is increased, onset of turbulence can be determined accurately and reliably. Our results imply that experimental investigation of turbulence may be feasible by using ferrofluids. Our study of transition to and evolution of turbulence in the Taylor-Couette ferrofluidic flow system provides insights into the challenging problem of turbulence control."}],"isi":1,"year":"2015","date_updated":"2025-09-29T10:58:13Z","author":[{"id":"2EE67FDC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5964-0203","last_name":"Altmeyer","first_name":"Sebastian","full_name":"Altmeyer, Sebastian"},{"last_name":"Do","full_name":"Do, Younghae","first_name":"Younghae"},{"first_name":"Ying","full_name":"Lai, Ying","last_name":"Lai"}],"type":"journal_article","scopus_import":"1","department":[{"_id":"BjHo"}],"volume":5,"article_processing_charge":"No"},{"year":"2015","author":[{"first_name":"Dominique","full_name":"Attali, Dominique","last_name":"Attali"},{"last_name":"Bauer","orcid":"0000-0002-9683-0724","id":"2ADD483A-F248-11E8-B48F-1D18A9856A87","first_name":"Ulrich","full_name":"Bauer, Ulrich"},{"last_name":"Devillers","full_name":"Devillers, Olivier","first_name":"Olivier"},{"first_name":"Marc","full_name":"Glisse, Marc","last_name":"Glisse"},{"first_name":"André","full_name":"Lieutier, André","last_name":"Lieutier"}],"date_updated":"2026-06-18T17:57:28Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.comgeo.2014.08.010"}],"isi":1,"department":[{"_id":"HeEd"}],"volume":48,"related_material":{"record":[{"relation":"earlier_version","id":"2812","status":"public"}]},"type":"journal_article","scopus_import":"1","article_processing_charge":"No","corr_author":"1","ddc":["500"],"quality_controlled":"1","OA_place":"publisher","date_published":"2015-06-03T00:00:00Z","publication":"Computational Geometry: Theory and Applications","publisher":"Elsevier","intvolume":"        48","abstract":[{"text":"We consider the problem of deciding whether the persistent homology group of a simplicial pair (K,L) can be realized as the homology H∗(X) of some complex X with L ⊂ X ⊂ K. We show that this problem is NP-complete even if K is embedded in double-struck R3. As a consequence, we show that it is NP-hard to simplify level and sublevel sets of scalar functions on double-struck S3 within a given tolerance constraint. This problem has relevance to the visualization of medical images by isosurfaces. We also show an implication to the theory of well groups of scalar functions: not every well group can be realized by some level set, and deciding whether a well group can be realized is NP-hard.","lang":"eng"}],"oa_version":"Published Version","OA_type":"free access","publication_status":"published","title":"Homological reconstruction and simplification in R3","fulldoi":"https://doi.org/10.1016/j.comgeo.2014.08.010","_id":"1805","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Attali D, Bauer U, Devillers O, Glisse M, Lieutier A. Homological reconstruction and simplification in R3. <i>Computational Geometry: Theory and Applications</i>. 2015;48(8):606-621. doi:<a href=\"https://doi.org/10.1016/j.comgeo.2014.08.010\">10.1016/j.comgeo.2014.08.010</a>","chicago":"Attali, Dominique, Ulrich Bauer, Olivier Devillers, Marc Glisse, and André Lieutier. “Homological Reconstruction and Simplification in R3.” <i>Computational Geometry: Theory and Applications</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.comgeo.2014.08.010\">https://doi.org/10.1016/j.comgeo.2014.08.010</a>.","ista":"Attali D, Bauer U, Devillers O, Glisse M, Lieutier A. 2015. Homological reconstruction and simplification in R3. Computational Geometry: Theory and Applications. 48(8), 606–621.","short":"D. Attali, U. Bauer, O. Devillers, M. Glisse, A. Lieutier, Computational Geometry: Theory and Applications 48 (2015) 606–621.","mla":"Attali, Dominique, et al. “Homological Reconstruction and Simplification in R3.” <i>Computational Geometry: Theory and Applications</i>, vol. 48, no. 8, Elsevier, 2015, pp. 606–21, doi:<a href=\"https://doi.org/10.1016/j.comgeo.2014.08.010\">10.1016/j.comgeo.2014.08.010</a>.","apa":"Attali, D., Bauer, U., Devillers, O., Glisse, M., &#38; Lieutier, A. (2015). Homological reconstruction and simplification in R3. <i>Computational Geometry: Theory and Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.comgeo.2014.08.010\">https://doi.org/10.1016/j.comgeo.2014.08.010</a>","ieee":"D. Attali, U. Bauer, O. Devillers, M. Glisse, and A. Lieutier, “Homological reconstruction and simplification in R3,” <i>Computational Geometry: Theory and Applications</i>, vol. 48, no. 8. Elsevier, pp. 606–621, 2015."},"ec_funded":1,"day":"03","month":"06","issue":"8","date_created":"2018-12-11T11:54:06Z","publist_id":"5305","status":"public","article_type":"original","doi":"10.1016/j.comgeo.2014.08.010","language":[{"iso":"eng"}],"project":[{"grant_number":"318493","_id":"255D761E-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Topological Complex Systems"}],"external_id":{"isi":["000357353200006"]},"page":"606 - 621","oa":1},{"abstract":[{"lang":"eng","text":"We study a double Cahn-Hilliard type functional related to the Gross-Pitaevskii energy of two-components Bose-Einstein condensates. In the case of large but same order intercomponent and intracomponent coupling strengths, we prove Γ-convergence to a perimeter minimisation functional with an inhomogeneous surface tension. We study the asymptotic behavior of the surface tension as the ratio between the intercomponent and intracomponent coupling strengths becomes very small or very large and obtain good agreement with the physical literature. We obtain as a consequence, symmetry breaking of the minimisers for the harmonic potential."}],"intvolume":"        21","publisher":"EDP Sciences","publication":"ESAIM - Control, Optimisation and Calculus of Variations","date_published":"2015-05-01T00:00:00Z","quality_controlled":"1","corr_author":"1","arxiv":1,"article_processing_charge":"No","type":"journal_article","scopus_import":"1","volume":21,"department":[{"_id":"RoSe"}],"isi":1,"main_file_link":[{"url":"http://arxiv.org/abs/1401.1727","open_access":"1"}],"author":[{"first_name":"Michael","full_name":"Goldman, Michael","last_name":"Goldman"},{"first_name":"Jimena","full_name":"Royo-Letelier, Jimena","id":"4D3BED28-F248-11E8-B48F-1D18A9856A87","last_name":"Royo-Letelier"}],"date_updated":"2025-09-23T10:45:09Z","year":"2015","oa":1,"page":"603 - 624","external_id":{"isi":["000356012000001"],"arxiv":["1401.1727"]},"doi":"10.1051/cocv/2014040","language":[{"iso":"eng"}],"status":"public","date_created":"2018-12-11T11:54:07Z","publist_id":"5303","issue":"3","month":"05","day":"01","citation":{"apa":"Goldman, M., &#38; Royo-Letelier, J. (2015). Sharp interface limit for two components Bose-Einstein condensates. <i>ESAIM - Control, Optimisation and Calculus of Variations</i>. EDP Sciences. <a href=\"https://doi.org/10.1051/cocv/2014040\">https://doi.org/10.1051/cocv/2014040</a>","ieee":"M. Goldman and J. Royo-Letelier, “Sharp interface limit for two components Bose-Einstein condensates,” <i>ESAIM - Control, Optimisation and Calculus of Variations</i>, vol. 21, no. 3. EDP Sciences, pp. 603–624, 2015.","mla":"Goldman, Michael, and Jimena Royo-Letelier. “Sharp Interface Limit for Two Components Bose-Einstein Condensates.” <i>ESAIM - Control, Optimisation and Calculus of Variations</i>, vol. 21, no. 3, EDP Sciences, 2015, pp. 603–24, doi:<a href=\"https://doi.org/10.1051/cocv/2014040\">10.1051/cocv/2014040</a>.","short":"M. Goldman, J. Royo-Letelier, ESAIM - Control, Optimisation and Calculus of Variations 21 (2015) 603–624.","chicago":"Goldman, Michael, and Jimena Royo-Letelier. “Sharp Interface Limit for Two Components Bose-Einstein Condensates.” <i>ESAIM - Control, Optimisation and Calculus of Variations</i>. EDP Sciences, 2015. <a href=\"https://doi.org/10.1051/cocv/2014040\">https://doi.org/10.1051/cocv/2014040</a>.","ama":"Goldman M, Royo-Letelier J. Sharp interface limit for two components Bose-Einstein condensates. <i>ESAIM - Control, Optimisation and Calculus of Variations</i>. 2015;21(3):603-624. doi:<a href=\"https://doi.org/10.1051/cocv/2014040\">10.1051/cocv/2014040</a>","ista":"Goldman M, Royo-Letelier J. 2015. Sharp interface limit for two components Bose-Einstein condensates. ESAIM - Control, Optimisation and Calculus of Variations. 21(3), 603–624."},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"1807","fulldoi":"https://doi.org/10.1051/cocv/2014040","title":"Sharp interface limit for two components Bose-Einstein condensates","publication_status":"published","oa_version":"Preprint"},{"publisher":"ACM","intvolume":"        25","publication":"ACM Transactions on Modeling and Computer Simulation","date_published":"2015-05-01T00:00:00Z","quality_controlled":"1","article_processing_charge":"No","volume":25,"department":[{"_id":"ToHe"}],"scopus_import":"1","type":"journal_article","date_updated":"2025-09-23T09:11:51Z","author":[{"id":"335E5684-F248-11E8-B48F-1D18A9856A87","last_name":"Gupta","first_name":"Ashutosh","full_name":"Gupta, Ashutosh"},{"full_name":"Henzinger, Thomas A","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","orcid":"0000−0002−2985−7724"}],"year":"2015","isi":1,"external_id":{"isi":["000354789200001"]},"doi":"10.1145/2745799","language":[{"iso":"eng"}],"status":"public","publist_id":"5302","date_created":"2018-12-11T11:54:07Z","month":"05","issue":"2","day":"01","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"chicago":"Gupta, Ashutosh, and Thomas A Henzinger. “Guest Editors’ Introduction to Special Issue on Computational Methods in Systems Biology.” <i>ACM Transactions on Modeling and Computer Simulation</i>. ACM, 2015. <a href=\"https://doi.org/10.1145/2745799\">https://doi.org/10.1145/2745799</a>.","ama":"Gupta A, Henzinger TA. Guest editors’ introduction to special issue on computational methods in systems biology. <i>ACM Transactions on Modeling and Computer Simulation</i>. 2015;25(2). doi:<a href=\"https://doi.org/10.1145/2745799\">10.1145/2745799</a>","ista":"Gupta A, Henzinger TA. 2015. Guest editors’ introduction to special issue on computational methods in systems biology. ACM Transactions on Modeling and Computer Simulation. 25(2), 7.","apa":"Gupta, A., &#38; Henzinger, T. A. (2015). Guest editors’ introduction to special issue on computational methods in systems biology. <i>ACM Transactions on Modeling and Computer Simulation</i>. ACM. <a href=\"https://doi.org/10.1145/2745799\">https://doi.org/10.1145/2745799</a>","ieee":"A. Gupta and T. A. Henzinger, “Guest editors’ introduction to special issue on computational methods in systems biology,” <i>ACM Transactions on Modeling and Computer Simulation</i>, vol. 25, no. 2. ACM, 2015.","mla":"Gupta, Ashutosh, and Thomas A. Henzinger. “Guest Editors’ Introduction to Special Issue on Computational Methods in Systems Biology.” <i>ACM Transactions on Modeling and Computer Simulation</i>, vol. 25, no. 2, 7, ACM, 2015, doi:<a href=\"https://doi.org/10.1145/2745799\">10.1145/2745799</a>.","short":"A. Gupta, T.A. Henzinger, ACM Transactions on Modeling and Computer Simulation 25 (2015)."},"_id":"1808","title":"Guest editors' introduction to special issue on computational methods in systems biology","article_number":"7","fulldoi":"https://doi.org/10.1145/2745799","oa_version":"None","publication_status":"published"}]