[{"article_number":"116056","intvolume":"        44","_id":"20116","pmid":1,"date_published":"2025-07-24T00:00:00Z","acknowledgement":"The study was supported by the National Natural Science Foundation of China (NSFC; 32230011, 91954206, and 31721001). We thank Dr. Deli Lin (Shanghai Jiao Tong University) for kind help with the laser confocal microscope observation and the Arabidopsis Biological Resource Center (ABRC) for providing T-DNA insertional mutants.","language":[{"iso":"eng"}],"scopus_import":"1","OA_place":"publisher","issue":"8","date_created":"2025-08-04T13:39:11Z","article_type":"original","publisher":"Elsevier","isi":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","abstract":[{"lang":"eng","text":"Auxin regulates various aspects of plant growth and development by modulating the transcription of target genes through the degradation of auxin/indole-3-acetic acid (Aux/IAA) repressors via the 26S proteasome. Proteasome regulator 1 (PTRE1), a positive regulator of proteasome activity, has been implicated in auxin-mediated proteasome suppression; however, the mechanism by which auxin modulates PTRE1 function remains unclear. Here, we demonstrate that auxin promotes the interaction between germin-like protein 1 (GLP1) and PTRE1, facilitating PTRE1 retention at the plasma membrane. The relocation of PTRE1 results in reduced nuclear 26S proteasome activity, and thus the attenuated Aux/IAA degradation and altered Aux/IAA homeostasis, ultimately resulting in suppressed auxin-mediated transcriptional regulation. Our findings uncover a previously uncharacterized regulatory axis in auxin signaling that controls Aux/IAA protein stability, functioning alongside the TIR1- and TRANSMEMBRANE KINASE 1 (TMK1)-mediated pathways, and highlight the coordination of auxin signaling from the cell surface to the nucleus via auxin-induced PTRE1 relocation, which fine-tunes Aux/IAA protein homeostasis and auxin responses."}],"quality_controlled":"1","author":[{"full_name":"Xu, Faqing","last_name":"Xu","first_name":"Faqing"},{"last_name":"Yu","first_name":"Yongqiang","full_name":"Yu, Yongqiang"},{"full_name":"Guan, Bin","last_name":"Guan","id":"56aad729-cca2-11ed-a45a-9b4138991a48","first_name":"Bin"},{"first_name":"Tongda","last_name":"Xu","full_name":"Xu, Tongda"},{"last_name":"Xu","first_name":"Zhihong","full_name":"Xu, Zhihong"},{"full_name":"Xue, Hongwei","first_name":"Hongwei","last_name":"Xue"}],"tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"department":[{"_id":"JiFr"}],"title":"Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis","publication_identifier":{"eissn":["2211-1247"]},"type":"journal_article","month":"07","publication":"Cell Reports","has_accepted_license":"1","external_id":{"pmid":["40714631"],"isi":["001542038500001"]},"citation":{"ieee":"F. Xu, Y. Yu, B. Guan, T. Xu, Z. Xu, and H. Xue, “Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis,” <i>Cell Reports</i>, vol. 44, no. 8. Elsevier, 2025.","chicago":"Xu, Faqing, Yongqiang Yu, Bin Guan, Tongda Xu, Zhihong Xu, and Hongwei Xue. “Germin-like Protein 1 Interacts with Proteasome Regulator 1 to Regulate Auxin Signaling by Controlling Aux/IAA Homeostasis.” <i>Cell Reports</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.celrep.2025.116056\">https://doi.org/10.1016/j.celrep.2025.116056</a>.","mla":"Xu, Faqing, et al. “Germin-like Protein 1 Interacts with Proteasome Regulator 1 to Regulate Auxin Signaling by Controlling Aux/IAA Homeostasis.” <i>Cell Reports</i>, vol. 44, no. 8, 116056, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.celrep.2025.116056\">10.1016/j.celrep.2025.116056</a>.","ista":"Xu F, Yu Y, Guan B, Xu T, Xu Z, Xue H. 2025. Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis. Cell Reports. 44(8), 116056.","short":"F. Xu, Y. Yu, B. Guan, T. Xu, Z. Xu, H. Xue, Cell Reports 44 (2025).","apa":"Xu, F., Yu, Y., Guan, B., Xu, T., Xu, Z., &#38; Xue, H. (2025). Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2025.116056\">https://doi.org/10.1016/j.celrep.2025.116056</a>","ama":"Xu F, Yu Y, Guan B, Xu T, Xu Z, Xue H. Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis. <i>Cell Reports</i>. 2025;44(8). doi:<a href=\"https://doi.org/10.1016/j.celrep.2025.116056\">10.1016/j.celrep.2025.116056</a>"},"year":"2025","file":[{"relation":"main_file","access_level":"open_access","checksum":"3c43e040a4a7a65ec67ae1d2bb81261a","success":1,"file_id":"20120","file_name":"2025_CellReports_Xu.pdf","date_created":"2025-08-05T06:15:09Z","content_type":"application/pdf","date_updated":"2025-08-05T06:15:09Z","file_size":24178018,"creator":"dernst"}],"file_date_updated":"2025-08-05T06:15:09Z","day":"24","article_processing_charge":"Yes","volume":44,"oa_version":"Published Version","OA_type":"gold","oa":1,"doi":"10.1016/j.celrep.2025.116056","publication_status":"published","status":"public","ddc":["580"],"date_updated":"2025-09-30T14:13:45Z","DOAJ_listed":"1"},{"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publisher":"Institute of Science and Technology Austria","date_published":"2025-08-04T00:00:00Z","page":"108","alternative_title":["ISTA Thesis"],"_id":"20117","OA_place":"publisher","date_created":"2025-08-04T15:24:21Z","acknowledgement":"I would also like to acknowledge the invaluable assistance provided by the Plant\r\nFacility, Imaging & Optics Facility, and the Lab Support Facility. The technical support and\r\nresources offered by these facilities were indispensable to the successful completion of my\r\nexperiments.","language":[{"iso":"eng"}],"related_material":{"record":[{"id":"18063","status":"public","relation":"part_of_dissertation"}]},"title":"The role of dynamin related protein 2A in cytokinin regulated plant growth and development","publication_identifier":{"issn":["2663-337X"]},"corr_author":"1","type":"dissertation","department":[{"_id":"GradSch"},{"_id":"EvBe"}],"author":[{"full_name":"Wang, Yiqun","id":"82F537F2-B517-11E9-84D7-6433E6697425","first_name":"Yiqun","last_name":"Wang"}],"has_accepted_license":"1","year":"2025","supervisor":[{"orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","last_name":"Benková","full_name":"Benková, Eva"}],"citation":{"apa":"Wang, Y. (2025). <i>The role of dynamin related protein 2A in cytokinin regulated plant growth and development</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20117\">https://doi.org/10.15479/AT-ISTA-20117</a>","ama":"Wang Y. The role of dynamin related protein 2A in cytokinin regulated plant growth and development. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20117\">10.15479/AT-ISTA-20117</a>","chicago":"Wang, Yiqun. “The Role of Dynamin Related Protein 2A in Cytokinin Regulated Plant Growth and Development.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20117\">https://doi.org/10.15479/AT-ISTA-20117</a>.","ista":"Wang Y. 2025. The role of dynamin related protein 2A in cytokinin regulated plant growth and development. Institute of Science and Technology Austria.","mla":"Wang, Yiqun. <i>The Role of Dynamin Related Protein 2A in Cytokinin Regulated Plant Growth and Development</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20117\">10.15479/AT-ISTA-20117</a>.","short":"Y. Wang, The Role of Dynamin Related Protein 2A in Cytokinin Regulated Plant Growth and Development, Institute of Science and Technology Austria, 2025.","ieee":"Y. Wang, “The role of dynamin related protein 2A in cytokinin regulated plant growth and development,” Institute of Science and Technology Austria, 2025."},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"PreCl"}],"degree_awarded":"PhD","month":"08","ddc":["580"],"doi":"10.15479/AT-ISTA-20117","status":"public","publication_status":"published","date_updated":"2026-04-07T11:49:34Z","day":"04","article_processing_charge":"No","file":[{"creator":"yiqwang","file_size":25798848,"date_updated":"2025-08-22T08:53:46Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2025-08-22T08:22:10Z","file_id":"20209","file_name":"2025_Wang_Yiqun_Thesis.docx","checksum":"36b87c17d12c7bf5955d6d812acb8d77","access_level":"closed","relation":"source_file"},{"content_type":"application/pdf","embargo":"2026-09-03","creator":"yiqwang","date_updated":"2025-09-03T09:36:52Z","file_size":12628313,"access_level":"closed","checksum":"8d7a2383f66377da675d379ec30ea0fe","relation":"main_file","date_created":"2025-08-22T10:32:30Z","embargo_to":"open_access","file_id":"20211","file_name":"2025_Wang_Yiqun_Thesis.pdf"}],"file_date_updated":"2025-09-03T09:36:52Z","oa_version":"Published Version"},{"year":"2025","supervisor":[{"full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X"}],"citation":{"ieee":"J. Svoboda, “Structural properties of games on graphs,” Institute of Science and Technology Austria, 2025.","apa":"Svoboda, J. (2025). <i>Structural properties of games on graphs</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20138\">https://doi.org/10.15479/AT-ISTA-20138</a>","ama":"Svoboda J. Structural properties of games on graphs. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20138\">10.15479/AT-ISTA-20138</a>","chicago":"Svoboda, Jakub. “Structural Properties of Games on Graphs.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20138\">https://doi.org/10.15479/AT-ISTA-20138</a>.","mla":"Svoboda, Jakub. <i>Structural Properties of Games on Graphs</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20138\">10.15479/AT-ISTA-20138</a>.","short":"J. Svoboda, Structural Properties of Games on Graphs, Institute of Science and Technology Austria, 2025.","ista":"Svoboda J. 2025. Structural properties of games on graphs. Institute of Science and Technology Austria."},"has_accepted_license":"1","degree_awarded":"PhD","month":"08","ec_funded":1,"date_updated":"2026-04-07T11:49:12Z","doi":"10.15479/AT-ISTA-20138","status":"public","publication_status":"published","ddc":["000","519"],"oa_version":"Published Version","oa":1,"file":[{"date_created":"2025-08-14T09:54:43Z","file_name":"2025_Svoboda_Jakub_Thesis.pdf","file_id":"20177","success":1,"checksum":"c6c4df9777f4537940de7ab392ad57e2","access_level":"open_access","relation":"main_file","creator":"jsvoboda","file_size":5927291,"date_updated":"2025-08-14T09:54:43Z","content_type":"application/pdf"},{"relation":"source_file","access_level":"closed","checksum":"485e9f9822821bc03666d245d80aaa08","file_name":"2025_Svoboda_Jakub_Thesis.zip","file_id":"20178","date_created":"2025-08-14T09:55:20Z","content_type":"application/zip","date_updated":"2025-08-21T11:48:39Z","file_size":6731815,"creator":"jsvoboda"}],"project":[{"_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020","name":"Formal Methods for Stochastic Models: Algorithms and Applications","grant_number":"863818"}],"file_date_updated":"2025-08-21T11:48:39Z","article_processing_charge":"No","day":"05","publisher":"Institute of Science and Technology Austria","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","acknowledgement":"This work was supported by the European Research Council CoG 863818 (ForMSMArt) and Austrian Science Fund 10.55776/COE12.\r\n","language":[{"iso":"eng"}],"OA_place":"publisher","date_created":"2025-08-05T14:33:59Z","page":"167","_id":"20138","alternative_title":["ISTA Thesis"],"date_published":"2025-08-05T00:00:00Z","publication_identifier":{"issn":["2663-337X"]},"type":"dissertation","corr_author":"1","title":"Structural properties of games on graphs","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"12787"},{"status":"public","relation":"part_of_dissertation","id":"12101"},{"status":"public","relation":"part_of_dissertation","id":"12257"},{"status":"public","relation":"part_of_dissertation","id":"15297"},{"status":"public","relation":"part_of_dissertation","id":"18703"}]},"author":[{"last_name":"Svoboda","orcid":"0000-0002-1419-3267","id":"130759D2-D7DD-11E9-87D2-DE0DE6697425","first_name":"Jakub","full_name":"Svoboda, Jakub"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"department":[{"_id":"GradSch"},{"_id":"KrCh"}],"abstract":[{"text":"The evolution shapes the world around us.\r\nNot only in biology, where the fittest individuals spread their genes but also in physics and social dynamics, the evolutionary forces determine the development of a state of matter or public opinions.\r\nMany models describe these dynamics.\r\nThis thesis examines the role of the structure in the models of selection.\r\nThe population structure is represented as a graph or a network, and each vertex is occupied by one individual.\r\nEvery individual has a type and fitness that represents the reproductive potential and depends on the type, occupied vertex, and the arrangement of the neighbors.\r\nThe evolution is modeled in discrete steps; in one step, one individual is replaced by a neighbor selected randomly with the influence of fitness.\r\n\r\n\r\n\r\nThe role of the networks is widely examined in the literature.\r\nThe structures that promote the spread of the desired type compared to the structureless case are called amplifiers.\r\nThe existence of amplifiers in various settings is an intensively studied topic, and in some settings, the amplifiers have been identified.\r\nMoreover, there are other important questions about the number of steps until one type spreads over the whole network (fixation time), the computational complexity, and the questions about the robustness of these processes.\r\n\r\n\r\nThis thesis explores the role of structure in evolution from many perspectives.\r\nFirst, it introduces different models and various choices that can be made in the models of evolution.\r\nIt highlights the role of the structure in the real world and how this is reflected in these models.\r\nThen, it describes the previous results and open problems.\r\nSecond, the thesis describes an amplifier for two variants of the Moran process: one with a constant birth rate and the other with a constant death rate.\r\nThis is an important contribution to the robustness of the amplification.\r\nThird, the thesis determines the complexity of spatial games.\r\nThese are processes where the fitness comes from a game, and the strength of selection is high.\r\nIt shows that determining the fate of cooperation in these games is a PSPACE-complete problem.\r\nFourth, the thesis describes the amplifier of cooperation for spatial games.\r\nThis is the first amplifier in this setting.\r\nFifth, the thesis examines the coexistence in the Moran process with environmental heterogeneity.\r\nIn this setting, the fitness depends not only on the type of the individual but also on the occupied vertex.\r\nThe chapter determines the relationship between the interactions of vertices of different types and the coexistence time.\r\nSixth, the thesis examines the social balance on networks and proposes a stochastic dynamic partially aware of the state of the graph, which reaches a balanced position quickly.\r\nFinally, the thesis presents conclusions and outlines the directions for future work.\r\n\r\n\r\n","lang":"eng"}]},{"external_id":{"pmid":["40730155"],"isi":["001603560700005"]},"year":"2025","citation":{"ieee":"Z. Zhang <i>et al.</i>, “Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites,” <i>Cell</i>, vol. 188, no. 21. Elsevier, p. 5862–5877.e23, 2025.","short":"Z. Zhang, T.C. Todeschini, Y. Wu, R. Kogay, A. Naji, J. Cardenas Rodriguez, R. Mondi, D. Kaganovich, D.W. Taylor, J.P.K. Bravo, M. Teplova, T. Amen, E. Koonin, D.J. Patel, F.L. Nobrega, Cell 188 (2025) 5862–5877.e23.","ista":"Zhang Z, Todeschini TC, Wu Y, Kogay R, Naji A, Cardenas Rodriguez J, Mondi R, Kaganovich D, Taylor DW, Bravo JPK, Teplova M, Amen T, Koonin E, Patel DJ, Nobrega FL. 2025. Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. Cell. 188(21), 5862–5877.e23.","mla":"Zhang, Zhiying, et al. “Kiwa Is a Membrane-Embedded Defense Supercomplex Activated at Phage Attachment Sites.” <i>Cell</i>, vol. 188, no. 21, Elsevier, 2025, p. 5862–5877.e23, doi:<a href=\"https://doi.org/10.1016/j.cell.2025.07.002\">10.1016/j.cell.2025.07.002</a>.","chicago":"Zhang, Zhiying, Thomas C. Todeschini, Yi Wu, Roman Kogay, Ameena Naji, Joaquin Cardenas Rodriguez, Rupavidhya Mondi, et al. “Kiwa Is a Membrane-Embedded Defense Supercomplex Activated at Phage Attachment Sites.” <i>Cell</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.cell.2025.07.002\">https://doi.org/10.1016/j.cell.2025.07.002</a>.","apa":"Zhang, Z., Todeschini, T. C., Wu, Y., Kogay, R., Naji, A., Cardenas Rodriguez, J., … Nobrega, F. L. (2025). Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2025.07.002\">https://doi.org/10.1016/j.cell.2025.07.002</a>","ama":"Zhang Z, Todeschini TC, Wu Y, et al. Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. <i>Cell</i>. 2025;188(21):5862-5877.e23. doi:<a href=\"https://doi.org/10.1016/j.cell.2025.07.002\">10.1016/j.cell.2025.07.002</a>"},"has_accepted_license":"1","month":"10","publication":"Cell","date_updated":"2025-12-29T14:15:58Z","doi":"10.1016/j.cell.2025.07.002","publication_status":"published","status":"public","PlanS_conform":"1","ddc":["570"],"oa_version":"Published Version","OA_type":"hybrid","oa":1,"file_date_updated":"2025-12-29T14:15:25Z","file":[{"content_type":"application/pdf","creator":"dernst","date_updated":"2025-12-29T14:15:25Z","file_size":32104588,"access_level":"open_access","checksum":"b944de5fbd7455f58e1ff338ad352239","relation":"main_file","date_created":"2025-12-29T14:15:25Z","success":1,"file_id":"20875","file_name":"2025_Cell_Zhang.pdf"}],"article_processing_charge":"Yes (in subscription journal)","day":"16","volume":188,"article_type":"original","publisher":"Elsevier","isi":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We thank Rotem Sorek (Weizmann Institute of Science) for the Lambda Gam mutant and Ian Molineux (University of Texas) for T4Δgp2. We thank You Yu (Zhejiang University-University of Edinburgh Institute) and J. De La Cruz (MSK) for assistance with cryo-EM data collection and Lyuqin Zheng (MSK) for discussions on structural analysis. We thank the Imaging and Microscopy Centre (IMC) at the University of Southampton. This work was supported by Royal Society grant RGS\\R2\\222312 to F.L.N.; Welch Foundation grant F-1938 and National Institutes of Health R35GM138348 to D.W.T.; Wessex Medical Research Innovation grant AE06 to T.A.; and NIH grant GM145888 and Maloris Foundation and Memorial Sloan-Kettering Core grant (P30-CA008748) to D.J.P. In addition to MSKCC cryo-EM resources, some of this work was performed at the National Center for CryoEM Access and Training (NCCAT) and the Simons Electron Microscopy Center located at the New York Structural Biology Center, supported by the NIH Common Fund Transformative High Resolution Cryo-Electron Microscopy program (U24 GM129539) and Simons Foundation (SF349247) and NY State Assembly grants. This research used NSLS-II MX X-ray User Resources (FMX) of the National Synchrotron Light Source II, operated for the DOE Office of Science by Brookhaven National Laboratory under contract no. DE-SC0012704. The Center for BioMolecular Structure (CBMS) is primarily supported by the NIH, the National Institute of General Medical Sciences (NIGMS) through a Center Core P30 Grant (P30GM133893), and by the DOE Office of Biological and Environmental Research (KP1605010). R.K. and E.V.K. are supported by the Intramural Research Program of the NIH (National Library of Medicine).","language":[{"iso":"eng"}],"scopus_import":"1","issue":"21","date_created":"2025-08-07T05:00:04Z","OA_place":"publisher","page":"5862-5877.e23","_id":"20143","intvolume":"       188","pmid":1,"date_published":"2025-10-16T00:00:00Z","publication_identifier":{"eissn":["1097-4172"],"issn":["0092-8674"]},"type":"journal_article","title":"Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites","author":[{"first_name":"Zhiying","last_name":"Zhang","full_name":"Zhang, Zhiying"},{"full_name":"Todeschini, Thomas C.","first_name":"Thomas C.","last_name":"Todeschini"},{"full_name":"Wu, Yi","first_name":"Yi","last_name":"Wu"},{"last_name":"Kogay","first_name":"Roman","full_name":"Kogay, Roman"},{"full_name":"Naji, Ameena","first_name":"Ameena","last_name":"Naji"},{"full_name":"Cardenas Rodriguez, Joaquin","first_name":"Joaquin","last_name":"Cardenas Rodriguez"},{"first_name":"Rupavidhya","last_name":"Mondi","full_name":"Mondi, Rupavidhya"},{"full_name":"Kaganovich, Daniel","first_name":"Daniel","last_name":"Kaganovich"},{"last_name":"Taylor","first_name":"David W.","full_name":"Taylor, David W."},{"orcid":"0000-0003-0456-0753","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","first_name":"Jack Peter Kelly","last_name":"Bravo","full_name":"Bravo, Jack Peter Kelly"},{"full_name":"Teplova, Marianna","last_name":"Teplova","first_name":"Marianna"},{"first_name":"Triana","last_name":"Amen","full_name":"Amen, Triana"},{"last_name":"Koonin","first_name":"Eugene","full_name":"Koonin, Eugene"},{"full_name":"Patel, Dinshaw J.","first_name":"Dinshaw J.","last_name":"Patel"},{"full_name":"Nobrega, Franklin L.","last_name":"Nobrega","first_name":"Franklin L."}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"department":[{"_id":"JaBr"}],"quality_controlled":"1","abstract":[{"text":"Bacteria and archaea deploy diverse antiviral defense systems, many of which remain mechanistically uncharacterized. Here, we characterize Kiwa, a widespread two-component system composed of the transmembrane sensor KwaA and the DNA-binding effector KwaB. Cryogenic electron microscopy (cryo-EM) analysis reveals that KwaA and KwaB assemble into a large, membrane-associated supercomplex. Upon phage binding, KwaA senses infection at the membrane, leading to KwaB binding of ejected phage DNA and inhibition of replication and late transcription, without inducing host cell death. Although KwaB can bind DNA independently, its antiviral activity requires association with KwaA, suggesting spatial or conformational regulation. We show that the phage-encoded DNA-mimic protein Gam directly binds and inhibits KwaB but that co-expression with the Gam-targeted RecBCD system restores protection by Kiwa. Our findings support a model in which Kiwa coordinates membrane-associated detection of phage infection with downstream DNA binding by its effector, forming a spatially coordinated antiviral mechanism.","lang":"eng"}]},{"article_processing_charge":"No","abstract":[{"text":"This criteria catalogue and the accompanying assessment questions were developed by a working group of KEMÖ (Kooperation E-Medien Österreich, the Austrian Academic Library Consortium). They are intended to support research institutions and organisations in the evaluation of Open Science Infrastructures. The 20 criteria outlined in the catalogue provide a structured basis for making informed decisions regarding the financial support of these infrastructures.\r\n\r\nThe assessment questions are intended to be completed by Open Science Infrastructures and can be shared with them accordingly.","lang":"eng"}],"day":"07","oa":1,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"department":[{"_id":"E-Lib"}],"oa_version":"Published Version","author":[{"last_name":"Gredler","first_name":"Paul","full_name":"Gredler, Paul"},{"first_name":"Christian","last_name":"Kaier","full_name":"Kaier, Christian"},{"full_name":"Danowski, Patrick","orcid":"0000-0002-6026-4409","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87","first_name":"Patrick","last_name":"Danowski"},{"first_name":"Michael","last_name":"Zoyer","full_name":"Zoyer, Michael"},{"last_name":"Rieck","first_name":"Katharina","full_name":"Rieck, Katharina"},{"full_name":"Ferus, Andreas","last_name":"Ferus","first_name":"Andreas"},{"last_name":"Rosenberger","first_name":"Elisabeth","full_name":"Rosenberger, Elisabeth"},{"full_name":"Löffler, Alexander","first_name":"Alexander","last_name":"Löffler"},{"full_name":"Hofer, Lisa","first_name":"Lisa","last_name":"Hofer"},{"last_name":"Still","first_name":"Laura","full_name":"Still, Laura"}],"OA_type":"gold","ddc":["020"],"doi":"10.5281/zenodo.15269364","title":"Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures","status":"public","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5281/zenodo.15269364"}],"type":"working_paper","date_updated":"2025-08-11T07:20:03Z","date_published":"2025-08-07T00:00:00Z","_id":"20146","OA_place":"publisher","date_created":"2025-08-07T11:10:14Z","month":"08","language":[{"iso":"eng"}],"has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Zenodo","citation":{"ista":"Gredler P, Kaier C, Danowski P, Zoyer M, Rieck K, Ferus A, Rosenberger E, Löffler A, Hofer L, Still L. 2025. Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures, Zenodo,p.","short":"P. Gredler, C. Kaier, P. Danowski, M. Zoyer, K. Rieck, A. Ferus, E. Rosenberger, A. Löffler, L. Hofer, L. Still, Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures, Zenodo, 2025.","mla":"Gredler, Paul, et al. <i>Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures</i>. Zenodo, 2025, doi:<a href=\"https://doi.org/10.5281/zenodo.15269364\">10.5281/zenodo.15269364</a>.","chicago":"Gredler, Paul, Christian Kaier, Patrick Danowski, Michael Zoyer, Katharina Rieck, Andreas Ferus, Elisabeth Rosenberger, Alexander Löffler, Lisa Hofer, and Laura Still. <i>Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures</i>. Zenodo, 2025. <a href=\"https://doi.org/10.5281/zenodo.15269364\">https://doi.org/10.5281/zenodo.15269364</a>.","ama":"Gredler P, Kaier C, Danowski P, et al. <i>Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures</i>. Zenodo; 2025. doi:<a href=\"https://doi.org/10.5281/zenodo.15269364\">10.5281/zenodo.15269364</a>","apa":"Gredler, P., Kaier, C., Danowski, P., Zoyer, M., Rieck, K., Ferus, A., … Still, L. (2025). <i>Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures</i>. Zenodo. <a href=\"https://doi.org/10.5281/zenodo.15269364\">https://doi.org/10.5281/zenodo.15269364</a>","ieee":"P. Gredler <i>et al.</i>, <i>Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures</i>. Zenodo, 2025."},"year":"2025"},{"publication_status":"published","status":"public","doi":"10.15479/AT-ISTA-20147","ddc":["000"],"date_updated":"2026-04-07T12:02:57Z","project":[{"grant_number":"Z211","name":"Formal methods for the design and analysis of complex systems","_id":"25F42A32-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"grant_number":"101020093","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","call_identifier":"H2020","name":"Vigilant Algorithmic Monitoring of Software"}],"file":[{"date_updated":"2025-09-10T08:19:51Z","file_size":8884801,"creator":"esarac","content_type":"application/x-zip-compressed","file_id":"20200","file_name":"2025_Sarac_NaciEge_Thesis.zip","date_created":"2025-08-21T09:40:28Z","relation":"source_file","checksum":"0f3015f1db36576a23d8d669afb60b41","access_level":"closed"},{"creator":"esarac","date_updated":"2025-08-21T09:40:34Z","file_size":2955584,"content_type":"application/pdf","date_created":"2025-08-21T09:40:34Z","success":1,"file_name":"2025_Sarac_NaciEge_Thesis.pdf","file_id":"20201","checksum":"332ed2fe61f580641664ec3f05d30f14","access_level":"open_access","relation":"main_file"}],"file_date_updated":"2025-09-10T08:19:51Z","article_processing_charge":"No","day":"07","oa_version":"Published Version","oa":1,"has_accepted_license":"1","supervisor":[{"full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2985-7724","first_name":"Thomas A","last_name":"Henzinger"}],"year":"2025","citation":{"ieee":"N. E. Sarac, “A monitoring-oriented theory and classification of quantitative specifications,” Institute of Science and Technology Austria, 2025.","chicago":"Sarac, Naci E. “A Monitoring-Oriented Theory and Classification of Quantitative Specifications.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20147\">https://doi.org/10.15479/AT-ISTA-20147</a>.","short":"N.E. Sarac, A Monitoring-Oriented Theory and Classification of Quantitative Specifications, Institute of Science and Technology Austria, 2025.","mla":"Sarac, Naci E. <i>A Monitoring-Oriented Theory and Classification of Quantitative Specifications</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20147\">10.15479/AT-ISTA-20147</a>.","ista":"Sarac NE. 2025. A monitoring-oriented theory and classification of quantitative specifications. Institute of Science and Technology Austria.","apa":"Sarac, N. E. (2025). <i>A monitoring-oriented theory and classification of quantitative specifications</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20147\">https://doi.org/10.15479/AT-ISTA-20147</a>","ama":"Sarac NE. A monitoring-oriented theory and classification of quantitative specifications. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20147\">10.15479/AT-ISTA-20147</a>"},"ec_funded":1,"month":"08","degree_awarded":"PhD","title":"A monitoring-oriented theory and classification of quantitative specifications","related_material":{"record":[{"id":"11775","relation":"part_of_dissertation","status":"public"},{"status":"deleted","relation":"part_of_dissertation","id":"13140"},{"relation":"part_of_dissertation","status":"public","id":"19741"},{"id":"9356","status":"public","relation":"part_of_dissertation"},{"status":"deleted","relation":"part_of_dissertation","id":"19643"},{"id":"17634","status":"public","relation":"part_of_dissertation"},{"id":"20342","status":"public","relation":"part_of_dissertation"},{"id":"13221","status":"public","relation":"part_of_dissertation"}]},"corr_author":"1","type":"dissertation","publication_identifier":{"issn":["2663-337X"]},"abstract":[{"text":"Quantitative properties offer a framework for specifying and verifying system behaviors beyond the traditional boolean perspective. For example, while a boolean property may specify whether a server eventually grants every request it receives, a quantitative one may map each server execution to its average response time. This quantitative view is relatively well-studied in the context of static verification. However, although such properties often appear in practice as performance or robustness measures in a dynamic verification context, a general theoretical framework for their analysis and classification from a monitoring perspective is still missing.\r\n\r\nIn this thesis, we aim to develop such a framework that takes resource-precision tradeoffs of monitors as a central consideration. We present the first theory of monitorability for quantitative properties where monitors can be naturally approximate and compared regarding their precision and resource use. In particular, we show that additional monitor resources such as registers or states lead to strictly better approximations for some properties. To enable such analyses in a machine-model independent way, we describe an abstract notion of monitors that can be instantiated with concrete models of monitors. Within this framework, we study how abstract monitors behave and identify classes of properties amenable to approximate monitoring with resource-precision considerations. We then extend the boolean safety-liveness dichotomy and safety-progress hierarchy to the quantitative setting with a monitoring perspective. In particular, we prove that every property is the pointwise minimum of a safety property and a liveness property, and properties that are both safe and co-safe can be approximately monitored arbitrarily precisely using only finitely many states. We also study the classes of quantitative properties definable by finite-state quantitative automata and provide algorithms for deciding their safety or liveness as well as their safety-liveness decompositions. Finally, we present the first general-purpose tool for automating the analysis, verification, and monitoring of quantitative automata.\r\n\r\n-------------------------------------------------------------------------------------------------------------------------------------------------------------- In reference to IEEE copyrighted material which is used with permission in this thesis, the IEEE does not\r\nendorse any of ISTA's products or services. Internal or personal use of this\r\nmaterial is permitted. If interested in reprinting/republishing IEEE copyrighted material for advertising or promotional\r\npurposes or for creating new collective works for resale or redistribution, please go to\r\nhttp://www.ieee.org/publications_standards/publications/rights/rights_link.html to learn how to obtain a License from\r\nRightsLink.\r\n","lang":"eng"}],"author":[{"full_name":"Sarac, Naci E","last_name":"Sarac","first_name":"Naci E","id":"8C6B42F8-C8E6-11E9-A03A-F2DCE5697425"}],"department":[{"_id":"GradSch"},{"_id":"ToHe"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publisher":"Institute of Science and Technology Austria","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"20147","alternative_title":["ISTA Thesis"],"page":"149","date_published":"2025-08-07T00:00:00Z","language":[{"iso":"eng"}],"acknowledgement":"This work was supported in part by the Austrian Science Fund (FWF)\r\nunder grant Z211-N23 (Wittgenstein Award) and the ERC-2020-AdG 101020093.\r\n","date_created":"2025-08-07T15:57:57Z","OA_place":"publisher"},{"OA_place":"publisher","date_created":"2025-08-08T09:18:02Z","acknowledgement":"I would like to acknowledge the\r\nfinancial support of the European Research Council through the ERC-SyG grant “Pushing from\r\nwithin: Control of cell shape, integrity and motility by cytoskeletal pushing forces”\r\n(01071793), which made this research possible. ","language":[{"iso":"eng"}],"date_published":"2025-08-08T00:00:00Z","page":"114","_id":"20149","alternative_title":["ISTA Thesis"],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publisher":"Institute of Science and Technology Austria","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"department":[{"_id":"GradSch"},{"_id":"MiSi"}],"author":[{"full_name":"Dos Reis Rodrigues, Patricia","last_name":"Dos Reis Rodrigues","orcid":"0000-0003-1681-508X","id":"26E95904-5160-11E9-9C0B-C5B0DC97E90F","first_name":"Patricia"}],"abstract":[{"text":"Immune responses depend on the coordinated and efficient migration of leukocytes. These\r\ncells, which are embedded and tightly confined within tissues, must navigate and traverse\r\ndiverse and complex three-dimensional environments. Leukocytes adapt their locomotory\r\nbehavior to the mechanical, geometrical, and biochemical characteristics of their\r\nsurroundings. In low-density environments, where the pore size of the interstitial matrix\r\nallows free passage, these cells position the nucleus directly behind the lamellipodium, the\r\nprotrusive actin structure that forms the leading front of the cell. In this configuration, they\r\nuse the nucleus as a gauge to identify the path of least resistance.\r\nHere, we show that in high-density environments, where the pore size precludes free passage\r\nof the cell body, leukocytes reposition the microtubule-organizing center (MTOC) and\r\nassociated organelles in front of the nucleus. In this configuration, they use actin structures\r\nprotruding orthogonally to the direction of migration in order to open a path for the cell body.\r\nWe identify two distinct actin populations that serve this purpose at different subcellular\r\nlocalizations. At the leading edge, local indentation of the plasma membrane leads to\r\nrecruitment of the Wiskott-Aldrich syndrome protein (WASp), which, via Arp2/3, results in\r\nthe formation of individual actin foci. At the cell body, actin polymerization is triggered by\r\nDOCK8, a Cdc42 exchange factor, resulting in the formation of a central actin pool.\r\nWe demonstrate that the central and peripheral actin pools are functionally communicating\r\nand that depletion of the central actin pool leads to increased actin accumulation at the cell\r\nfront, resulting in excessive extension of the leading edge.","lang":"eng"}],"publication_identifier":{"issn":["2663-337X"]},"corr_author":"1","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","type":"dissertation","related_material":{"record":[{"id":"10703","status":"public","relation":"part_of_dissertation"},{"id":"20082","relation":"part_of_dissertation","status":"public"}]},"title":"Coordination of protrusive forces in immune cell migration ","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"NanoFab"}],"degree_awarded":"PhD","month":"08","citation":{"ieee":"P. Dos Reis Rodrigues, “Coordination of protrusive forces in immune cell migration ,” Institute of Science and Technology Austria, 2025.","ista":"Dos Reis Rodrigues P. 2025. Coordination of protrusive forces in immune cell migration . Institute of Science and Technology Austria.","short":"P. Dos Reis Rodrigues, Coordination of Protrusive Forces in Immune Cell Migration , Institute of Science and Technology Austria, 2025.","mla":"Dos Reis Rodrigues, Patricia. <i>Coordination of Protrusive Forces in Immune Cell Migration </i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20149\">10.15479/AT-ISTA-20149</a>.","chicago":"Dos Reis Rodrigues, Patricia. “Coordination of Protrusive Forces in Immune Cell Migration .” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20149\">https://doi.org/10.15479/AT-ISTA-20149</a>.","ama":"Dos Reis Rodrigues P. Coordination of protrusive forces in immune cell migration . 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20149\">10.15479/AT-ISTA-20149</a>","apa":"Dos Reis Rodrigues, P. (2025). <i>Coordination of protrusive forces in immune cell migration </i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20149\">https://doi.org/10.15479/AT-ISTA-20149</a>"},"supervisor":[{"full_name":"Sixt, Michael K","last_name":"Sixt","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179"}],"year":"2025","has_accepted_license":"1","oa":1,"oa_version":"Published Version","article_processing_charge":"No","day":"08","file_date_updated":"2025-08-27T13:02:28Z","project":[{"name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces","_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd","grant_number":"101071793"}],"file":[{"creator":"prodrigu","file_size":63885565,"date_updated":"2025-08-27T12:59:10Z","content_type":"application/pdf","date_created":"2025-08-27T12:59:10Z","file_id":"20232","file_name":"2025_ReisRodrigues_Patricia_Thesis.pdf","success":1,"access_level":"open_access","checksum":"fda8a1070667c3562263f4867609b41b","relation":"main_file"},{"creator":"prodrigu","file_size":50483434,"date_updated":"2025-08-27T13:02:28Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2025-08-27T13:00:30Z","file_id":"20233","file_name":"2025_ReisRodrigues_Patricia_Thesis.docx","checksum":"e8b65affcbce846a926454df4b2867b9","access_level":"closed","relation":"source_file"}],"date_updated":"2026-04-28T13:26:50Z","ddc":["570"],"doi":"10.15479/AT-ISTA-20149","status":"public","publication_status":"published"},{"isi":1,"article_type":"original","publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"20154","intvolume":"        48","page":"645-654","date_published":"2025-09-01T00:00:00Z","pmid":1,"language":[{"iso":"eng"}],"acknowledgement":"The work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (470322152 – T1347/3-1; 497658532 – T1347/4-1; 507965872 – T1347/5-1; and 460333672 – CRC1540 Exploring Brain Mechanics) to T.T., the Schram Foundation (T.T.), the European Research Council (ERC-2018-STG, 804468 EAGER; ERC-2023-COG, 101125034 NEUTIME) to T.T., the Hans-Georg Geis und Xue Hong Dong-Geis Foundation and Forschungsstiftung Medizin am Universitätsklinikum Erlangen to T.T., and the Interdisciplinary Centre for Clinical Research Erlangen (Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Erlangen; P162 to T.T.). We thank Dr Laura J. Harrison for editing assistance.","issue":"9","OA_place":"publisher","date_created":"2025-08-10T22:01:29Z","scopus_import":"1","title":"Long-lived cellular molecules in the brain","corr_author":"1","type":"journal_article","publication_identifier":{"eissn":["1878-108X"],"issn":["0166-2236"]},"quality_controlled":"1","abstract":[{"lang":"eng","text":"In long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellular identity and plasticity to preserve brain function. Although extensive studies indicate the importance of recycling and regenerating cellular molecules to maintain cellular homeostasis, recent evidence has shown that some proteins and RNAs do not turn over for months and even years. We propose that these long-lived cellular molecules may be the basis for maintaining brain function in the long term, but also a potential convergent target of brain aging. We highlight key discoveries and challenges, and propose potential directions to unravel the mystery of brain cell longevity."}],"author":[{"full_name":"Hetzer, Martin W","last_name":"Hetzer","first_name":"Martin W","orcid":"0000-0002-2111-992X","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"},{"full_name":"Toda, Tomohisa","last_name":"Toda","first_name":"Tomohisa"}],"department":[{"_id":"MaHe"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","citation":{"mla":"Hetzer, Martin, and Tomohisa Toda. “Long-Lived Cellular Molecules in the Brain.” <i>Trends in Neurosciences</i>, vol. 48, no. 9, Elsevier, 2025, pp. 645–54, doi:<a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">10.1016/j.tins.2025.07.004</a>.","ista":"Hetzer M, Toda T. 2025. Long-lived cellular molecules in the brain. Trends in Neurosciences. 48(9), 645–654.","short":"M. Hetzer, T. Toda, Trends in Neurosciences 48 (2025) 645–654.","chicago":"Hetzer, Martin, and Tomohisa Toda. “Long-Lived Cellular Molecules in the Brain.” <i>Trends in Neurosciences</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">https://doi.org/10.1016/j.tins.2025.07.004</a>.","ama":"Hetzer M, Toda T. Long-lived cellular molecules in the brain. <i>Trends in Neurosciences</i>. 2025;48(9):645-654. doi:<a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">10.1016/j.tins.2025.07.004</a>","apa":"Hetzer, M., &#38; Toda, T. (2025). Long-lived cellular molecules in the brain. <i>Trends in Neurosciences</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">https://doi.org/10.1016/j.tins.2025.07.004</a>","ieee":"M. Hetzer and T. Toda, “Long-lived cellular molecules in the brain,” <i>Trends in Neurosciences</i>, vol. 48, no. 9. Elsevier, pp. 645–654, 2025."},"year":"2025","external_id":{"isi":["001568965400001"],"pmid":["40744775"]},"month":"09","publication":"Trends in Neurosciences","PlanS_conform":"1","publication_status":"published","status":"public","doi":"10.1016/j.tins.2025.07.004","ddc":["570"],"date_updated":"2025-12-29T13:47:58Z","file":[{"date_created":"2025-12-29T13:47:27Z","success":1,"file_name":"2025_TrendsNeurosciences_Hetzer.pdf","file_id":"20873","access_level":"open_access","checksum":"90942491b499f70b0bf48b8aec2e7387","relation":"main_file","creator":"dernst","date_updated":"2025-12-29T13:47:27Z","file_size":327847,"content_type":"application/pdf"}],"file_date_updated":"2025-12-29T13:47:27Z","volume":48,"article_processing_charge":"Yes (in subscription journal)","day":"01","OA_type":"hybrid","oa_version":"Published Version","oa":1},{"isi":1,"article_type":"original","publisher":"Society for Industrial and Applied Mathematics","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        57","_id":"20155","page":"3587-3622","date_published":"2025-08-01T00:00:00Z","language":[{"iso":"eng"}],"acknowledgement":"The first author was funded by the European Union's Horizon 2020 research andinnovation program under the Marie Sklodowska-Curie grant agreements 754362 and 101034413,and partially by Project EFI (ANR-17-CE40-0030) of the French National Research Agency (ANR).The work of the second author was partially funded by the European Research Council (ERC) underthe European Union's Horizon 2020 research and innovation programme (grant agreement 810367),and by the Agence Nationale de la Recherche under grants ANR-19-CE40-0010 (QuAMProcs) andANR-21-CE40-0006 (SINEQ).","issue":"4","date_created":"2025-08-10T22:01:29Z","OA_place":"repository","scopus_import":"1","title":"How to construct explicit decay rates for kinetic Fokker–Planck equations?","type":"journal_article","corr_author":"1","arxiv":1,"publication_identifier":{"issn":["0036-1410"],"eissn":["1095-7154"]},"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2302.14506","open_access":"1"}],"abstract":[{"lang":"eng","text":"We study time averages for the norm of solutions to kinetic Fokker–Planck equations associated with general Hamiltonians. We provide fully explicit and constructive decay estimates for systems subject to a confining potential, allowing fat-tail, subexponential and (super-)exponential local equilibria, which also include the classic Maxwellian case. The key step in our estimates is a modified Poincaré inequality, obtained via a Lions–Poincaré inequality and an averaging lemma."}],"quality_controlled":"1","author":[{"full_name":"Brigati, Giovanni","first_name":"Giovanni","id":"63ff57e8-1fbb-11ee-88f2-f558ffc59cf1","last_name":"Brigati"},{"full_name":"Stoltz, Gabriel","last_name":"Stoltz","first_name":"Gabriel"}],"department":[{"_id":"JaMa"}],"year":"2025","citation":{"chicago":"Brigati, Giovanni, and Gabriel Stoltz. “How to Construct Explicit Decay Rates for Kinetic Fokker–Planck Equations?” <i>SIAM Journal on Mathematical Analysis</i>. Society for Industrial and Applied Mathematics, 2025. <a href=\"https://doi.org/10.1137/24M1700351\">https://doi.org/10.1137/24M1700351</a>.","ista":"Brigati G, Stoltz G. 2025. How to construct explicit decay rates for kinetic Fokker–Planck equations? SIAM Journal on Mathematical Analysis. 57(4), 3587–3622.","short":"G. Brigati, G. Stoltz, SIAM Journal on Mathematical Analysis 57 (2025) 3587–3622.","mla":"Brigati, Giovanni, and Gabriel Stoltz. “How to Construct Explicit Decay Rates for Kinetic Fokker–Planck Equations?” <i>SIAM Journal on Mathematical Analysis</i>, vol. 57, no. 4, Society for Industrial and Applied Mathematics, 2025, pp. 3587–622, doi:<a href=\"https://doi.org/10.1137/24M1700351\">10.1137/24M1700351</a>.","ama":"Brigati G, Stoltz G. How to construct explicit decay rates for kinetic Fokker–Planck equations? <i>SIAM Journal on Mathematical Analysis</i>. 2025;57(4):3587-3622. doi:<a href=\"https://doi.org/10.1137/24M1700351\">10.1137/24M1700351</a>","apa":"Brigati, G., &#38; Stoltz, G. (2025). How to construct explicit decay rates for kinetic Fokker–Planck equations? <i>SIAM Journal on Mathematical Analysis</i>. Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/24M1700351\">https://doi.org/10.1137/24M1700351</a>","ieee":"G. Brigati and G. Stoltz, “How to construct explicit decay rates for kinetic Fokker–Planck equations?,” <i>SIAM Journal on Mathematical Analysis</i>, vol. 57, no. 4. Society for Industrial and Applied Mathematics, pp. 3587–3622, 2025."},"external_id":{"arxiv":["2302.14506"],"isi":["001550830900006"]},"ec_funded":1,"month":"08","publication":"SIAM Journal on Mathematical Analysis","status":"public","publication_status":"published","doi":"10.1137/24M1700351","date_updated":"2025-11-05T13:51:40Z","project":[{"grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program"}],"volume":57,"day":"01","article_processing_charge":"No","OA_type":"green","oa_version":"Preprint","oa":1},{"date_updated":"2026-04-07T11:50:26Z","doi":"10.15479/AT-ISTA-20167","status":"public","publication_status":"published","ddc":["570"],"oa_version":"Published Version","file_date_updated":"2025-09-18T14:12:29Z","project":[{"name":"Molecular mechanisms of neural circuit function","_id":"23870BE8-32DE-11EA-91FC-C7463DDC885E","grant_number":"209504/A/17/Z"},{"grant_number":"ALTF 302-2019","name":"Control of gene expression at the endoplasmic reticulum","_id":"23813290-32DE-11EA-91FC-C7463DDC885E"}],"file":[{"date_created":"2025-09-08T14:33:50Z","file_id":"20311","file_name":"2025_Schoen_Hanna_Thesis.docx","access_level":"closed","checksum":"b40c74404b8d9593802dabf57bfdf10f","relation":"source_file","creator":"hschoen","file_size":78812587,"date_updated":"2025-09-09T08:57:04Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document"},{"embargo_to":"open_access","date_created":"2025-09-11T14:20:59Z","file_name":"2025_Schoen_Hanna_Thesis.pdf","file_id":"20347","access_level":"closed","checksum":"16abc3ff66396ce2457fe07ffa8bed90","relation":"main_file","creator":"hschoen","file_size":9667057,"date_updated":"2025-09-18T14:12:29Z","content_type":"application/pdf","embargo":"2026-09-15"}],"day":"13","article_processing_charge":"No","citation":{"ieee":"H. Schön, “The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs,” Institute of Science and Technology Austria, 2025.","short":"H. Schön, The ER Complex SUTU-7/MACO-1 Regulates the Fate of MRNAs Encoding GPCRs, Institute of Science and Technology Austria, 2025.","mla":"Schön, Hanna. <i>The ER Complex SUTU-7/MACO-1 Regulates the Fate of MRNAs Encoding GPCRs</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20167\">10.15479/AT-ISTA-20167</a>.","ista":"Schön H. 2025. The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs. Institute of Science and Technology Austria.","chicago":"Schön, Hanna. “The ER Complex SUTU-7/MACO-1 Regulates the Fate of MRNAs Encoding GPCRs.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20167\">https://doi.org/10.15479/AT-ISTA-20167</a>.","ama":"Schön H. The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20167\">10.15479/AT-ISTA-20167</a>","apa":"Schön, H. (2025). <i>The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20167\">https://doi.org/10.15479/AT-ISTA-20167</a>"},"year":"2025","supervisor":[{"last_name":"de Bono","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","first_name":"Mario","orcid":"0000-0001-8347-0443","full_name":"de Bono, Mario"}],"has_accepted_license":"1","degree_awarded":"PhD","month":"08","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"publication_identifier":{"isbn":["978-3-99078-061-9"],"issn":["2663-337X"]},"type":"dissertation","corr_author":"1","title":"The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs","author":[{"full_name":"Schön, Hanna","id":"C8E17EDC-D7AA-11E9-B7B7-45ECE5697425","first_name":"Hanna","last_name":"Schön"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"department":[{"_id":"GradSch"},{"_id":"MaDe"}],"publisher":"Institute of Science and Technology Austria","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","acknowledgement":"This work was supported by EMBO (ALTF 302-2019 to Niko Amin-Wetzel), the FWF\r\n(ESPRIT PR1054E140 to Niko Amin-Wetzel), the European Research Council\r\n(Advanced Grant 269058 to Mario de Bono) and Wellcome (209504/A/17/Z\r\nInvestigator Award to Mario de Bono). ","language":[{"iso":"eng"}],"OA_place":"publisher","date_created":"2025-08-13T11:13:13Z","page":"171","alternative_title":["ISTA Thesis"],"_id":"20167","date_published":"2025-08-13T00:00:00Z"},{"isi":1,"publisher":"Elsevier","article_type":"review","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        72","_id":"20182","article_number":"101411","date_published":"2025-12-01T00:00:00Z","language":[{"iso":"eng"}],"acknowledgement":"This work was supported by an Austrian Research Fund (FWF) grant to B.V. (PAT 8748323) and by the Louisiana Board of Regents Research Competitiveness Subprogram (LEQSF(2025-28)-RD-A-20) to MAT.","date_created":"2025-08-17T22:01:35Z","OA_place":"publisher","scopus_import":"1","title":"Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation","corr_author":"1","type":"journal_article","publication_identifier":{"eissn":["2214-5753"],"issn":["2214-5745"]},"abstract":[{"text":"Sex chromosomes have evolved many times throughout the tree of life, and understanding what has shaped their unusual morphological, sequence, and regulatory features has been a long-standing goal. Most early insights into insect sex chromosome biology came from a few model species, such as the fruit fly Drosophila melanogaster, which limited broad-scale evolutionary inferences. More recently, extensive comparative genomics studies have uncovered several unexpected patterns, which we highlight in this review. First, we describe the conservation of the ancestral X chromosome over 450 million years but also its recurrent turnover (i.e. its reversal to an autosome when a new X chromosome arose) in at least one order. We then summarize classical and more recent findings on how insects modulate the expression of X-linked genes following the degradation of the Y chromosome and how the diverse mechanisms of dosage compensation identified may elucidate important principles of sex chromosome regulatory evolution.","lang":"eng"}],"quality_controlled":"1","author":[{"last_name":"Toups","first_name":"Melissa A","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9752-7380","full_name":"Toups, Melissa A"},{"first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso","full_name":"Vicoso, Beatriz"}],"department":[{"_id":"BeVi"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","year":"2025","citation":{"chicago":"Toups, Melissa A, and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>.","ista":"Toups MA, Vicoso B. 2025. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. Current Opinion in Insect Science. 72, 101411.","mla":"Toups, Melissa A., and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>, vol. 72, 101411, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>.","short":"M.A. Toups, B. Vicoso, Current Opinion in Insect Science 72 (2025).","apa":"Toups, M. A., &#38; Vicoso, B. (2025). Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>","ama":"Toups MA, Vicoso B. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. 2025;72. doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>","ieee":"M. A. Toups and B. Vicoso, “Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation,” <i>Current Opinion in Insect Science</i>, vol. 72. Elsevier, 2025."},"external_id":{"isi":["001582424100001"]},"publication":"Current Opinion in Insect Science","month":"12","publication_status":"published","PlanS_conform":"1","status":"public","doi":"10.1016/j.cois.2025.101411","ddc":["570"],"date_updated":"2025-12-30T13:14:38Z","file":[{"content_type":"application/pdf","creator":"dernst","file_size":897079,"date_updated":"2025-12-30T13:14:20Z","access_level":"open_access","checksum":"262640abc34277686b56eb60102976f6","relation":"main_file","date_created":"2025-12-30T13:14:20Z","file_name":"2025_CurrOpinionInsectScience_Toups.pdf","file_id":"20917","success":1}],"file_date_updated":"2025-12-30T13:14:20Z","project":[{"name":"Sex chromosomes in evolution and development","_id":"8ed82125-16d5-11f0-9cad-fbcae312235b","grant_number":"PAT 8748323"}],"volume":72,"article_processing_charge":"Yes (via OA deal)","day":"01","OA_type":"hybrid","oa_version":"Published Version","oa":1},{"ddc":["570"],"doi":"10.1038/s41467-025-62484-5","publication_status":"published","PlanS_conform":"1","status":"public","DOAJ_listed":"1","date_updated":"2025-09-01T09:47:29Z","article_processing_charge":"Yes","day":"04","volume":16,"file":[{"content_type":"application/pdf","file_size":3775190,"date_updated":"2025-09-01T09:46:44Z","creator":"dernst","relation":"main_file","checksum":"f28e73963ea1f55876d0d1afca0f706a","access_level":"open_access","file_id":"20261","file_name":"2025_NatureComm_Segos.pdf","success":1,"date_created":"2025-09-01T09:46:44Z"}],"file_date_updated":"2025-09-01T09:46:44Z","oa":1,"oa_version":"Published Version","OA_type":"gold","has_accepted_license":"1","external_id":{"pmid":["40759648"]},"citation":{"ista":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. 2025. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. Nature Communications. 16, 7174.","mla":"Segos, Ioannis, et al. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” <i>Nature Communications</i>, vol. 16, 7174, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-62484-5\">10.1038/s41467-025-62484-5</a>.","short":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E.J. Lambie, B. Conradt, Nature Communications 16 (2025).","chicago":"Segos, Ioannis, Jens Van Eeckhoven, Simon Berger, Nikhil Mishra, Eric J. Lambie, and Barbara Conradt. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-62484-5\">https://doi.org/10.1038/s41467-025-62484-5</a>.","ama":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-62484-5\">10.1038/s41467-025-62484-5</a>","apa":"Segos, I., Van Eeckhoven, J., Berger, S., Mishra, N., Lambie, E. J., &#38; Conradt, B. (2025). Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-62484-5\">https://doi.org/10.1038/s41467-025-62484-5</a>","ieee":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E. J. Lambie, and B. Conradt, “Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025."},"year":"2025","publication":"Nature Communications","month":"08","title":"Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo","publication_identifier":{"eissn":["2041-1723"]},"type":"journal_article","abstract":[{"lang":"eng","text":"The unequal segregation of organelles has been proposed to be an intrinsic mechanism that contributes to cell fate divergence during asymmetric cell division; however, in vivo evidence is sparse. Using super-resolution microscopy, we analysed the segregation of organelles during the division of the neuroblast QL.p in C. elegans larvae. QL.p divides to generate a daughter that survives, QL.pa, and a daughter that dies, QL.pp. We found that mitochondria segregate unequally by density and morphology and that this is dependent on mitochondrial dynamics. Furthermore, we found that mitochondrial density in QL.pp correlates with the time it takes QL.pp to die. We propose that low mitochondrial density in QL.pp promotes the cell death fate and ensures that QL.pp dies in a highly reproducible and timely manner. Our results provide in vivo evidence that the unequal segregation of mitochondria can contribute to cell fate divergence during asymmetric cell division in a developing animal."}],"quality_controlled":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"department":[{"_id":"CaHe"}],"author":[{"full_name":"Segos, Ioannis","last_name":"Segos","first_name":"Ioannis"},{"full_name":"Van Eeckhoven, Jens","last_name":"Van Eeckhoven","first_name":"Jens"},{"full_name":"Berger, Simon","first_name":"Simon","last_name":"Berger"},{"full_name":"Mishra, Nikhil","orcid":"0000-0002-6425-5788","first_name":"Nikhil","id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","last_name":"Mishra"},{"full_name":"Lambie, Eric J.","last_name":"Lambie","first_name":"Eric J."},{"full_name":"Conradt, Barbara","last_name":"Conradt","first_name":"Barbara"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","publisher":"Springer Nature","date_published":"2025-08-04T00:00:00Z","pmid":1,"article_number":"7174","intvolume":"        16","_id":"20183","scopus_import":"1","OA_place":"publisher","date_created":"2025-08-17T22:01:35Z","acknowledgement":"We thank members of the Conradt lab, the Center for Cell and Molecular Dynamics (https://www.uclccmd.co.uk/) and T. Schedl for discussions and comments on the manuscript. We thank L. McGuinness for excellent technical support. Some strains were provided by the Caenorhabditis Genetics Center (CGC), which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We thank Alex Hajnal (University of Zurich, Switzerland) and Andrew deMello (ETH Zurich, Switzerland) for their support of S.B. This work was supported by a predoctoral fellowship from the Studienstiftung des deutschen Volkes to NM, funds from UCL (Division of Biosciences, UCL LSM Capital Equipment Fund) to B.C., and a Wolfson Fellowship from the Royal Society (https://royalsociety.org/) to B.C. (RSWF\\R1\\180008), and the Biotechnology and Biological Sciences Research Council (https://bbsrc.ukri.org/) (BB/V007572/1 and BB/V015648/1to B.C.).","language":[{"iso":"eng"}]},{"acknowledgement":"This work was supported by the Secretaría de Ciencia y Técnica (33620230100926CB), Universidad Nacional de Córdoba; and the Agencia Nacional de Promoción Científica y Técnica (PICT 2018-4527).\r\n\r\n","language":[{"iso":"eng"}],"scopus_import":"1","OA_place":"publisher","date_created":"2025-08-17T22:01:35Z","article_number":"1148","_id":"20184","intvolume":"         8","pmid":1,"date_published":"2025-08-02T00:00:00Z","publisher":"Springer Nature","article_type":"original","isi":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","author":[{"full_name":"Castell, Sofía D.","last_name":"Castell","first_name":"Sofía D."},{"last_name":"Fernandez","first_name":"Consuelo M.","full_name":"Fernandez, Consuelo M."},{"full_name":"Tumas, Ignacio N.","last_name":"Tumas","first_name":"Ignacio N."},{"full_name":"Margara, Lucía M.","first_name":"Lucía M.","last_name":"Margara"},{"first_name":"Maria C","id":"273e0cbd-72f0-11ef-b75a-f9f932e292fa","last_name":"Miserendino","full_name":"Miserendino, Maria C"},{"first_name":"Danilo G.","last_name":"Ceschin","full_name":"Ceschin, Danilo G."},{"full_name":"Pezza, Roberto J.","first_name":"Roberto J.","last_name":"Pezza"},{"first_name":"Mariela R.","last_name":"Monti","full_name":"Monti, Mariela R."}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"department":[{"_id":"PaSc"},{"_id":"GradSch"}],"abstract":[{"text":"Specialized DNA polymerases facilitate various cellular processes. Despite extensive research, the mutagenic effects of these error-prone enzymes on genomes are not fully understood. Here we show that Pol IV promotes genomic instability in Pseudomonas aeruginosa by misincorporating oxidized guanine nucleotides. This activity led to a distinctive mutational signature, characterized by A-to-C transversions occurring preferentially at AT sites flanked by a 5’G and/or 3’C. Furthermore, Pol IV preferentially targeted pathogenicity genes located at specific chromosomal locations near the replication termination region and rRNA-encoding operons. Half of the mutation events catalyzed by Pol IV impaired gene function. This can be attributed to the bias of Pol IV for mutating codons with its preferred sequence contexts, leading to substitutions to unreactive alanine and glycine residues. Remarkably, mutation signatures identified for Pol IV were found in clinical isolate genomes of P. aeruginosa, providing compelling evidence for its role in genetic diversification during pathogen adaptation.","lang":"eng"}],"quality_controlled":"1","publication_identifier":{"eissn":["2399-3642"]},"type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1038/s42003-025-08589-5","open_access":"1"}],"title":"The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa","month":"08","publication":"Communications Biology","external_id":{"isi":["001541878500001"],"pmid":["40753298"]},"year":"2025","citation":{"ieee":"S. D. Castell <i>et al.</i>, “The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa,” <i>Communications Biology</i>, vol. 8. Springer Nature, 2025.","chicago":"Castell, Sofía D., Consuelo M. Fernandez, Ignacio N. Tumas, Lucía M. Margara, Maria C Miserendino, Danilo G. Ceschin, Roberto J. Pezza, and Mariela R. Monti. “The Low-Fidelity DNA Pol IV Accelerates Evolution of Pathogenicity Genes in Pseudomonas Aeruginosa.” <i>Communications Biology</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s42003-025-08589-5\">https://doi.org/10.1038/s42003-025-08589-5</a>.","short":"S.D. Castell, C.M. Fernandez, I.N. Tumas, L.M. Margara, M.C. Miserendino, D.G. Ceschin, R.J. Pezza, M.R. Monti, Communications Biology 8 (2025).","mla":"Castell, Sofía D., et al. “The Low-Fidelity DNA Pol IV Accelerates Evolution of Pathogenicity Genes in Pseudomonas Aeruginosa.” <i>Communications Biology</i>, vol. 8, 1148, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s42003-025-08589-5\">10.1038/s42003-025-08589-5</a>.","ista":"Castell SD, Fernandez CM, Tumas IN, Margara LM, Miserendino MC, Ceschin DG, Pezza RJ, Monti MR. 2025. The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. Communications Biology. 8, 1148.","apa":"Castell, S. D., Fernandez, C. M., Tumas, I. N., Margara, L. M., Miserendino, M. C., Ceschin, D. G., … Monti, M. R. (2025). The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-025-08589-5\">https://doi.org/10.1038/s42003-025-08589-5</a>","ama":"Castell SD, Fernandez CM, Tumas IN, et al. The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. <i>Communications Biology</i>. 2025;8. doi:<a href=\"https://doi.org/10.1038/s42003-025-08589-5\">10.1038/s42003-025-08589-5</a>"},"has_accepted_license":"1","oa_version":"Published Version","OA_type":"gold","oa":1,"article_processing_charge":"Yes","day":"02","volume":8,"date_updated":"2025-09-30T14:18:46Z","DOAJ_listed":"1","doi":"10.1038/s42003-025-08589-5","PlanS_conform":"1","status":"public","publication_status":"published","ddc":["570"]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","isi":1,"article_type":"original","publisher":"Springer Nature","date_published":"2025-08-07T00:00:00Z","intvolume":"        35","_id":"20185","article_number":"306","date_created":"2025-08-17T22:01:35Z","OA_place":"publisher","issue":"10","scopus_import":"1","language":[{"iso":"eng"}],"acknowledgement":"The author would like to thank Corentin Fierobe, Vadim Kaloshin, Illya Koval and Yunzhe Li for useful discussions. The author would also like to thank the referee for useful remarks. Open access funding provided by Institute of Science and Technology (IST Austria). European Research Council (885707) Mr Daniel Tsodikovich","title":"Local rigidity for symplectic billiards","corr_author":"1","type":"journal_article","publication_identifier":{"issn":["1050-6926"]},"arxiv":1,"abstract":[{"text":"We show a local rigidity result for the integrability of symplectic billiards. We prove that any domain which is close to an ellipse, and for which the symplectic billiard map is rationally integrable must be an ellipse as well. This is in spirit of the result of [2] for Birkhoff billiards.","lang":"eng"}],"quality_controlled":"1","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"department":[{"_id":"VaKa"}],"author":[{"full_name":"Tsodikovich, Daniel","first_name":"Daniel","id":"04531810-fb3e-11ef-87f0-800a4ce333db","last_name":"Tsodikovich"}],"has_accepted_license":"1","citation":{"apa":"Tsodikovich, D. (2025). Local rigidity for symplectic billiards. <i>Journal of Geometric Analysis</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s12220-025-02148-4\">https://doi.org/10.1007/s12220-025-02148-4</a>","ama":"Tsodikovich D. Local rigidity for symplectic billiards. <i>Journal of Geometric Analysis</i>. 2025;35(10). doi:<a href=\"https://doi.org/10.1007/s12220-025-02148-4\">10.1007/s12220-025-02148-4</a>","ista":"Tsodikovich D. 2025. Local rigidity for symplectic billiards. Journal of Geometric Analysis. 35(10), 306.","short":"D. Tsodikovich, Journal of Geometric Analysis 35 (2025).","mla":"Tsodikovich, Daniel. “Local Rigidity for Symplectic Billiards.” <i>Journal of Geometric Analysis</i>, vol. 35, no. 10, 306, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1007/s12220-025-02148-4\">10.1007/s12220-025-02148-4</a>.","chicago":"Tsodikovich, Daniel. “Local Rigidity for Symplectic Billiards.” <i>Journal of Geometric Analysis</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s12220-025-02148-4\">https://doi.org/10.1007/s12220-025-02148-4</a>.","ieee":"D. Tsodikovich, “Local rigidity for symplectic billiards,” <i>Journal of Geometric Analysis</i>, vol. 35, no. 10. Springer Nature, 2025."},"year":"2025","external_id":{"arxiv":["2501.08849"],"isi":["001546433200002"]},"ec_funded":1,"publication":"Journal of Geometric Analysis","month":"08","ddc":["510"],"PlanS_conform":"1","publication_status":"published","status":"public","doi":"10.1007/s12220-025-02148-4","date_updated":"2025-12-30T09:29:27Z","volume":35,"article_processing_charge":"Yes (via OA deal)","day":"07","file":[{"creator":"dernst","date_updated":"2025-12-30T09:28:58Z","file_size":484344,"content_type":"application/pdf","date_created":"2025-12-30T09:28:58Z","success":1,"file_name":"2025_JourGeomAnalysis_Tsodikovich.pdf","file_id":"20907","checksum":"ed86500742b3fd93db3287558a630383","access_level":"open_access","relation":"main_file"}],"file_date_updated":"2025-12-30T09:28:58Z","project":[{"call_identifier":"H2020","_id":"9B8B92DE-BA93-11EA-9121-9846C619BF3A","name":"Spectral rigidity and integrability for billiards and geodesic flows","grant_number":"885707"}],"oa":1,"OA_type":"hybrid","oa_version":"Published Version"},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","isi":1,"article_type":"original","publisher":"Springer Nature","date_published":"2025-09-01T00:00:00Z","intvolume":"        62","_id":"20186","article_number":"30","date_created":"2025-08-17T22:01:36Z","issue":"3","OA_place":"publisher","scopus_import":"1","language":[{"iso":"eng"}],"acknowledgement":"This project was funded in part by the Austrian Science Fund (FWF) SFB project SpyCoDe F8502, Vienna Science and Technology Fund (WWTF) [10.47379/ICT19018] (ProbInG) and WWTF project ICT22-023 (TAIGER), National Science Foundation (NSF) CPS Award 1837680, NSF award ECCS-2144416 and NSF SaTC Award 2245114. Open access funding provided by Institute of Science and Technology (IST Austria).","title":"Gray-box runtime enforcement of hyperproperties","type":"journal_article","corr_author":"1","publication_identifier":{"issn":["0001-5903"],"eissn":["1432-0525"]},"quality_controlled":"1","abstract":[{"lang":"eng","text":"Enforcement of information-flow policies has been extensively studied by language-based approaches over the past few decades. In this paper, we propose an alternative, novel, general, and effective approach using enforcement of hyperproperties– a powerful formalism for expressing and reasoning about a wide range of information-flow security policies. We study black- vs. gray- vs. white-box enforcement of hyperproperties expressed by nondeterministic finite-word hyperautomata (NFH), where the enforcer has null, some, or complete information about the implementation of the system under scrutiny. Given an NFH, in order to generate a runtime enforcer, we reduce the problem to controller synthesis for hyperproperties and subsequently to the satisfiability problem for quantified Boolean formulas (QBFs). The resulting enforcers are transferable with low-overhead. We conduct a rich set of case studies, including information-flow control for JavaScript code, as well as synthesizing obfuscators for control plants."}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"department":[{"_id":"ToHe"}],"author":[{"full_name":"Hsu, Tzu Han","first_name":"Tzu Han","last_name":"Hsu"},{"id":"8b282559-50b0-11ef-861e-d6ace0d92e9b","first_name":"Ana A","last_name":"Oliveira Da Costa","full_name":"Oliveira Da Costa, Ana A"},{"full_name":"Wintenberg, Andrew","first_name":"Andrew","last_name":"Wintenberg"},{"full_name":"Bartocci, Ezio","last_name":"Bartocci","first_name":"Ezio"},{"first_name":"Borzoo","last_name":"Bonakdarpour","full_name":"Bonakdarpour, Borzoo"}],"has_accepted_license":"1","year":"2025","citation":{"ieee":"T. H. Hsu, A. A. Oliveira da Costa, A. Wintenberg, E. Bartocci, and B. Bonakdarpour, “Gray-box runtime enforcement of hyperproperties,” <i>Acta Informatica</i>, vol. 62, no. 3. Springer Nature, 2025.","ama":"Hsu TH, Oliveira da Costa AA, Wintenberg A, Bartocci E, Bonakdarpour B. Gray-box runtime enforcement of hyperproperties. <i>Acta Informatica</i>. 2025;62(3). doi:<a href=\"https://doi.org/10.1007/s00236-025-00502-1\">10.1007/s00236-025-00502-1</a>","apa":"Hsu, T. H., Oliveira da Costa, A. A., Wintenberg, A., Bartocci, E., &#38; Bonakdarpour, B. (2025). Gray-box runtime enforcement of hyperproperties. <i>Acta Informatica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00236-025-00502-1\">https://doi.org/10.1007/s00236-025-00502-1</a>","ista":"Hsu TH, Oliveira da Costa AA, Wintenberg A, Bartocci E, Bonakdarpour B. 2025. Gray-box runtime enforcement of hyperproperties. Acta Informatica. 62(3), 30.","mla":"Hsu, Tzu Han, et al. “Gray-Box Runtime Enforcement of Hyperproperties.” <i>Acta Informatica</i>, vol. 62, no. 3, 30, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1007/s00236-025-00502-1\">10.1007/s00236-025-00502-1</a>.","short":"T.H. Hsu, A.A. Oliveira da Costa, A. Wintenberg, E. Bartocci, B. Bonakdarpour, Acta Informatica 62 (2025).","chicago":"Hsu, Tzu Han, Ana A Oliveira da Costa, Andrew Wintenberg, Ezio Bartocci, and Borzoo Bonakdarpour. “Gray-Box Runtime Enforcement of Hyperproperties.” <i>Acta Informatica</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s00236-025-00502-1\">https://doi.org/10.1007/s00236-025-00502-1</a>."},"external_id":{"isi":["001546115300001"]},"month":"09","publication":"Acta Informatica","ddc":["000"],"PlanS_conform":"1","status":"public","publication_status":"published","doi":"10.1007/s00236-025-00502-1","date_updated":"2025-09-30T14:20:11Z","volume":62,"article_processing_charge":"Yes (via OA deal)","day":"01","file_date_updated":"2025-09-02T05:53:47Z","file":[{"access_level":"open_access","checksum":"90a43350fd4a8c5cb5b1b0e1aea7970d","relation":"main_file","date_created":"2025-09-02T05:53:47Z","file_id":"20267","file_name":"2025_ActaInformatica_Hsu.pdf","success":1,"content_type":"application/pdf","creator":"dernst","file_size":6505049,"date_updated":"2025-09-02T05:53:47Z"}],"project":[{"name":"Interface Theory for Security and Privacy","_id":"34a1b658-11ca-11ed-8bc3-c75229f0241e","grant_number":"F8502"}],"oa":1,"OA_type":"hybrid","oa_version":"Published Version"},{"publication_identifier":{"eissn":["1365-313X"],"issn":["0960-7412"]},"corr_author":"1","type":"journal_article","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"20362"}]},"title":"Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development","department":[{"_id":"EvBe"},{"_id":"JiFr"},{"_id":"GradSch"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"author":[{"last_name":"Babic","id":"db566d23-f6e0-11ea-865d-e6f270e968e7","first_name":"David","full_name":"Babic, David"},{"last_name":"Abualia","first_name":"Rashed","orcid":"0000-0002-9357-9415","id":"4827E134-F248-11E8-B48F-1D18A9856A87","full_name":"Abualia, Rashed"},{"last_name":"Fiedler","id":"7c417475-8972-11ed-ae7b-8b674ca26986","first_name":"Lukas","full_name":"Fiedler, Lukas"},{"full_name":"Qi, Linlin","last_name":"Qi","id":"44B04502-A9ED-11E9-B6FC-583AE6697425","orcid":"0000-0001-5187-8401","first_name":"Linlin"},{"last_name":"Tellier","first_name":"Frédérique","full_name":"Tellier, Frédérique"},{"id":"cced8a85-223e-11ed-af04-b0596c55053b","first_name":"Adrijana","last_name":"Smoljan","full_name":"Smoljan, Adrijana"},{"first_name":"Hana","id":"4CAAA450-78D2-11EA-8E57-B40A396E08BA","last_name":"Rakusova","full_name":"Rakusova, Hana"},{"full_name":"Valošek, Petr","id":"3CDB6F94-F248-11E8-B48F-1D18A9856A87","first_name":"Petr","last_name":"Valošek"},{"last_name":"Han","id":"31435098-F248-11E8-B48F-1D18A9856A87","first_name":"Huibin","full_name":"Han, Huibin"},{"full_name":"Benková, Eva","last_name":"Benková","orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva"},{"last_name":"Faure","first_name":"Jean Denis","full_name":"Faure, Jean Denis"},{"full_name":"Friml, Jiří","last_name":"Friml","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"quality_controlled":"1","abstract":[{"text":"Very long-chain fatty acids (VLCFAs), being constituents of different types of lipids, are critical factors in plant development, presumably due to their impact on the endomembrane system. The VLCFAs are synthesized in the endoplasmic reticulum by a heterotetrameric enzymatic complex including β-ketoacyl CoA reductase 1 (KCR1), whose mutant is lethal. Here, we describe the ectopic shoot meristems (esm) mutant, a viable kcr1 allele presumably affecting surface properties of the KCR1 protein. This kcr1-2 mutant shows reduced fatty acyl elongation that impacts VLCFAs. The kcr1-2 plants show severe defects during different stages of development, which all correlate with defects in polar localization and subcellular trafficking of PIN auxin transporters and resulting asymmetric auxin distribution. Detailed analysis of KCR1 expression and patterning defects in kcr1-2 suggests that KCR1 plays a role in delineating boundaries around meristematic and specialized differentiating tissues, including root and shoot meristems, initiating lateral roots, lateral root primordia, and trichomes. In these contexts, KCR1-produced VLCFAs may act in a non-cell-autonomous manner. Viable kcr1-2 represents a useful tool to study VLCFA roles in plant development and highlights VLCFAs as critical developmental factors at the interface of cell polarity and tissue development.","lang":"eng"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_type":"original","publisher":"Wiley","isi":1,"scopus_import":"1","OA_place":"publisher","date_created":"2025-08-17T22:01:36Z","issue":"3","acknowledgement":"We gratefully acknowledge the Imaging and Optics, Electron Microscopy (especially Vanessa Zheden for technical assistance) and Life Science (in particular Dorota Jaworska) facilities at ISTA for their continuous support. Authors would like to thank Michelle Gallei for advice during the generation of the transgenic lines; Zuzana Gelová for advice with DR5rev::GFP analyses; Ivan Kulich for help and advice on trichome imaging; Aline Monzer for generous help with hypocotyl and root analyses; Shutang Tan for help with the NGS data analysis; and Milan Župunski for advice on abiotic stress experiments. We would like to thank Dolf Weijers for the SOSEKI (SOK) marker line seeds. This work has benefited from the support of IJPB's Plant Observatory platforms P0-Chem.\r\n\r\nThis work was supported by Austrian Science Fund (FWF) (I 6123-B) and Science and Technology Department of Jiangxi Province (20223BCJ25037) to Huibin Han. The IJPB benefits from the support of Saclay Plant Sciences-SPS (ANR-17-EUR-0007).","language":[{"iso":"eng"}],"date_published":"2025-08-01T00:00:00Z","pmid":1,"article_number":"e70396","_id":"20187","intvolume":"       123","date_updated":"2026-04-07T11:52:02Z","ddc":["580"],"doi":"10.1111/tpj.70396","publication_status":"published","PlanS_conform":"1","status":"public","oa":1,"oa_version":"Published Version","OA_type":"hybrid","day":"01","article_processing_charge":"Yes (via OA deal)","volume":123,"project":[{"name":"Peptide receptors for auxin canalization in Arabidopsis","_id":"bd76d395-d553-11ed-ba76-f678c14f9033","grant_number":"I06123"}],"file_date_updated":"2025-09-01T14:09:31Z","file":[{"file_size":5791111,"date_updated":"2025-09-01T14:09:31Z","creator":"dernst","content_type":"application/pdf","file_id":"20264","file_name":"2025_PlantJournal_Babic.pdf","success":1,"date_created":"2025-09-01T14:09:31Z","relation":"main_file","access_level":"open_access","checksum":"1cdc3341d2d23101abca72521f1f23cb"}],"external_id":{"pmid":["40782342"],"isi":["001547884300001"]},"year":"2025","citation":{"ieee":"D. Babic <i>et al.</i>, “Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development,” <i>Plant Journal</i>, vol. 123, no. 3. Wiley, 2025.","ama":"Babic D, Abualia R, Fiedler L, et al. Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. <i>Plant Journal</i>. 2025;123(3). doi:<a href=\"https://doi.org/10.1111/tpj.70396\">10.1111/tpj.70396</a>","apa":"Babic, D., Abualia, R., Fiedler, L., Qi, L., Tellier, F., Smoljan, A., … Friml, J. (2025). Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. <i>Plant Journal</i>. Wiley. <a href=\"https://doi.org/10.1111/tpj.70396\">https://doi.org/10.1111/tpj.70396</a>","chicago":"Babic, David, Rashed Abualia, Lukas Fiedler, Linlin Qi, Frédérique Tellier, Adrijana Smoljan, Hana Rakusova, et al. “Biosynthesis of Very Long-Chain Fatty Acids Is Required for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic Development.” <i>Plant Journal</i>. Wiley, 2025. <a href=\"https://doi.org/10.1111/tpj.70396\">https://doi.org/10.1111/tpj.70396</a>.","short":"D. Babic, R. Abualia, L. Fiedler, L. Qi, F. Tellier, A. Smoljan, H. Rakusova, P. Valošek, H. Han, E. Benková, J.D. Faure, J. Friml, Plant Journal 123 (2025).","ista":"Babic D, Abualia R, Fiedler L, Qi L, Tellier F, Smoljan A, Rakusova H, Valošek P, Han H, Benková E, Faure JD, Friml J. 2025. Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. Plant Journal. 123(3), e70396.","mla":"Babic, David, et al. “Biosynthesis of Very Long-Chain Fatty Acids Is Required for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic Development.” <i>Plant Journal</i>, vol. 123, no. 3, e70396, Wiley, 2025, doi:<a href=\"https://doi.org/10.1111/tpj.70396\">10.1111/tpj.70396</a>."},"has_accepted_license":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"publication":"Plant Journal","month":"08"},{"author":[{"last_name":"Jikko","first_name":"Yuya","full_name":"Jikko, Yuya"},{"first_name":"Eriko","last_name":"Deguchi","full_name":"Deguchi, Eriko"},{"last_name":"Matsuda","first_name":"Kimiya","full_name":"Matsuda, Kimiya"},{"full_name":"Hino, Naoya","id":"5299a9ce-7679-11eb-a7bc-d1e62b936307","first_name":"Naoya","last_name":"Hino"},{"full_name":"Tsukiji, Shinya","first_name":"Shinya","last_name":"Tsukiji"},{"first_name":"Michiyuki","last_name":"Matsuda","full_name":"Matsuda, Michiyuki"},{"last_name":"Terai","first_name":"Kenta","full_name":"Terai, Kenta"}],"department":[{"_id":"CaHe"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"quality_controlled":"1","abstract":[{"lang":"eng","text":"Collective cell migration is coordinated by the front-to-rear intercellular propagation of EGFR-Ras-ERK pathway activation. However, the molecular mechanisms integrating front-to-rear information into this intercellular signaling cascade, particularly the determinants of cellular front-side specification, remain elusive. We visualized the activity of EGFR, Ras, Rac1 and Rab5A (hereafter Rab5) by using FRET biosensors and chemogenetic tools. Whereas EGFR activation was uniformly observed within cells, Ras activation was biased to the front side within cells. The polarized Ras activation depended on Merlin and Rac1, which also showed front-biased activation. Furthermore, Rab5, a crucial regulator of cell migration, demonstrated similar front-biased activation and was found to function downstream of Ras while being necessary for Rac1 activation. Thus, the positive feedback loop consisting of Ras, Rab5 and Rac1 is activated primarily at the front of collectively migrating cells. These findings offer new spatio-temporal insight into processing front–rear information during collective cell migration."}],"publication_identifier":{"eissn":["1477-9137"],"issn":[" 0021-9533"]},"type":"journal_article","title":"Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration","acknowledgement":"We are grateful to the members of the Matsuda Laboratory for their helpful input, to K. Hirano, T. Uesugi and K. Takakura, who provided technical assistance, and to the Medical Research Support Center of Kyoto University for DNA sequence analysis. This work was supported by the Kyoto University Live Imaging Center. Financial support was provided by Japan Society for the Promotion of Science (JSPS) KAKENHI grants (21H05226 to K.T., 19H00993 and 20H05898 to M.M.), a Japan Science and Technology Agency (JST) CREST grant (JPMJCR1654 to M.M.), and a JST Moonshot Research and Development Program grant (JPMJPS2022 to M.M.). Open Access funding provided by Tokushima University. Deposited in PMC for immediate release.","language":[{"iso":"eng"}],"scopus_import":"1","date_created":"2025-08-17T22:01:36Z","OA_place":"publisher","issue":"15","article_number":"263779","_id":"20188","intvolume":"       138","date_published":"2025-08-01T00:00:00Z","pmid":1,"article_type":"original","publisher":"The Company of Biologists","isi":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","OA_type":"hybrid","oa":1,"file_date_updated":"2025-09-01T10:02:24Z","file":[{"content_type":"application/pdf","creator":"dernst","date_updated":"2025-09-01T10:02:24Z","file_size":12393297,"checksum":"29f42619dab5ce251a20c769ed4581c0","access_level":"open_access","relation":"main_file","date_created":"2025-09-01T10:02:24Z","success":1,"file_name":"2025_JourCellScience_Jikko.pdf","file_id":"20262"}],"day":"01","article_processing_charge":"Yes (via OA deal)","volume":138,"date_updated":"2025-11-27T14:12:24Z","doi":"10.1242/jcs.263779","publication_status":"published","PlanS_conform":"1","status":"public","ddc":["570"],"publication":"Journal of Cell Science","month":"08","external_id":{"pmid":["40667649"],"isi":["001567723900009"]},"citation":{"ieee":"Y. Jikko <i>et al.</i>, “Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration,” <i>Journal of Cell Science</i>, vol. 138, no. 15. The Company of Biologists, 2025.","apa":"Jikko, Y., Deguchi, E., Matsuda, K., Hino, N., Tsukiji, S., Matsuda, M., &#38; Terai, K. (2025). Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. <i>Journal of Cell Science</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/jcs.263779\">https://doi.org/10.1242/jcs.263779</a>","ama":"Jikko Y, Deguchi E, Matsuda K, et al. Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. <i>Journal of Cell Science</i>. 2025;138(15). doi:<a href=\"https://doi.org/10.1242/jcs.263779\">10.1242/jcs.263779</a>","chicago":"Jikko, Yuya, Eriko Deguchi, Kimiya Matsuda, Naoya Hino, Shinya Tsukiji, Michiyuki Matsuda, and Kenta Terai. “Front-Biased Activation of the Ras-Rab5-Rac1 Loop Coordinates Collective Cell Migration.” <i>Journal of Cell Science</i>. The Company of Biologists, 2025. <a href=\"https://doi.org/10.1242/jcs.263779\">https://doi.org/10.1242/jcs.263779</a>.","ista":"Jikko Y, Deguchi E, Matsuda K, Hino N, Tsukiji S, Matsuda M, Terai K. 2025. Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. Journal of Cell Science. 138(15), 263779.","short":"Y. Jikko, E. Deguchi, K. Matsuda, N. Hino, S. Tsukiji, M. Matsuda, K. Terai, Journal of Cell Science 138 (2025).","mla":"Jikko, Yuya, et al. “Front-Biased Activation of the Ras-Rab5-Rac1 Loop Coordinates Collective Cell Migration.” <i>Journal of Cell Science</i>, vol. 138, no. 15, 263779, The Company of Biologists, 2025, doi:<a href=\"https://doi.org/10.1242/jcs.263779\">10.1242/jcs.263779</a>."},"year":"2025","has_accepted_license":"1"},{"oa":1,"OA_type":"hybrid","oa_version":"Published Version","volume":15931,"day":"01","article_processing_charge":"Yes (in subscription journal)","file_date_updated":"2025-09-02T05:46:10Z","project":[{"name":"Vigilant Algorithmic Monitoring of Software","call_identifier":"H2020","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","grant_number":"101020093"}],"file":[{"content_type":"application/pdf","creator":"dernst","date_updated":"2025-09-02T05:46:10Z","file_size":1078274,"access_level":"open_access","checksum":"15ec1bc9b9409d3b2736f4c9d5f42fd1","relation":"main_file","date_created":"2025-09-02T05:46:10Z","success":1,"file_name":"2025_CAV_Froleyks.pdf","file_id":"20266"}],"date_updated":"2025-12-01T12:34:05Z","ddc":["000"],"status":"public","publication_status":"published","doi":"10.1007/978-3-031-98668-0_14","publication":"37th International Conference on Computer Aided Verification","month":"01","ec_funded":1,"year":"2025","citation":{"mla":"Froleyks, Nils, et al. “Introducing Certificates to the Hardware Model Checking Competition.” <i>37th International Conference on Computer Aided Verification</i>, vol. 15931, Springer Nature, 2025, pp. 281–95, doi:<a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">10.1007/978-3-031-98668-0_14</a>.","short":"N. Froleyks, E. Yu, M. Preiner, A. Biere, K. Heljanko, in:, 37th International Conference on Computer Aided Verification, Springer Nature, 2025, pp. 281–295.","ista":"Froleyks N, Yu E, Preiner M, Biere A, Heljanko K. 2025. Introducing certificates to the hardware model checking competition. 37th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 15931, 281–295.","chicago":"Froleyks, Nils, Emily Yu, Mathias Preiner, Armin Biere, and Keijo Heljanko. “Introducing Certificates to the Hardware Model Checking Competition.” In <i>37th International Conference on Computer Aided Verification</i>, 15931:281–95. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">https://doi.org/10.1007/978-3-031-98668-0_14</a>.","apa":"Froleyks, N., Yu, E., Preiner, M., Biere, A., &#38; Heljanko, K. (2025). Introducing certificates to the hardware model checking competition. In <i>37th International Conference on Computer Aided Verification</i> (Vol. 15931, pp. 281–295). Zagreb, Croatia: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">https://doi.org/10.1007/978-3-031-98668-0_14</a>","ama":"Froleyks N, Yu E, Preiner M, Biere A, Heljanko K. Introducing certificates to the hardware model checking competition. In: <i>37th International Conference on Computer Aided Verification</i>. Vol 15931. Springer Nature; 2025:281-295. doi:<a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">10.1007/978-3-031-98668-0_14</a>","ieee":"N. Froleyks, E. Yu, M. Preiner, A. Biere, and K. Heljanko, “Introducing certificates to the hardware model checking competition,” in <i>37th International Conference on Computer Aided Verification</i>, Zagreb, Croatia, 2025, vol. 15931, pp. 281–295."},"external_id":{"isi":["001562507100014"]},"has_accepted_license":"1","department":[{"_id":"ToHe"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"author":[{"first_name":"Nils","last_name":"Froleyks","full_name":"Froleyks, Nils"},{"full_name":"Yu, Zhengqi","id":"20aa2ae8-f2f1-11ed-bbfa-8205053f1342","first_name":"Zhengqi","orcid":"0000-0002-4993-773X","last_name":"Yu"},{"full_name":"Preiner, Mathias","first_name":"Mathias","last_name":"Preiner"},{"full_name":"Biere, Armin","last_name":"Biere","first_name":"Armin"},{"first_name":"Keijo","last_name":"Heljanko","full_name":"Heljanko, Keijo"}],"abstract":[{"lang":"eng","text":"Certification was made mandatory for the first time in the latest hardware model checking competition. In this case study, we investigate the trade-offs of requiring certificates for both passing and failing properties in the competition. Our evaluation shows that participating model checkers were able to produce compact, correct certificates that could be verified with minimal overhead. Furthermore, the certifying winner of the competition outperforms the previous non-certifying state-of-the-art model checker, demonstrating that certification can be adopted without compromising model checking efficiency."}],"quality_controlled":"1","type":"conference","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783031986673"]},"title":"Introducing certificates to the hardware model checking competition","OA_place":"publisher","date_created":"2025-08-17T22:01:36Z","scopus_import":"1","language":[{"iso":"eng"}],"acknowledgement":"This work is supported in part by the ERC-2020-AdG 101020093, the LIT AI Lab funded by the State of Upper Austria, the Research Council of Finland under the project 336092, and a gift from Intel Corporation.\r\nFurthermore we of course also owe a big thank-you to the submitters of model checkers and benchmarks to the competition over all these years. Without their enthusiasm and support neither the competition nor this study would exist.","date_published":"2025-01-01T00:00:00Z","_id":"20189","intvolume":"     15931","alternative_title":["LNCS"],"page":"281-295","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","isi":1,"publisher":"Springer Nature","conference":{"end_date":"2025-07-25","name":"CAV: Computer Aided Verification","location":"Zagreb, Croatia","start_date":"2025-07-23"}},{"article_type":"original","publisher":"Wiley","isi":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_number":"e13859","_id":"20191","date_published":"2025-08-06T00:00:00Z","acknowledgement":"The authors acknowledge support from the 2BoSS project of the ERA-MIN3 program with the Spanish grant number PCI2022-132985/AEI/10.13039/50110001103, and funding from Generalitat de Catalunya 2021SGR01581 and European Union NextGenerationEU/PRTR. L.Yang, C.Huang, X.Lu, A.Yu, C.Li, J.Yu, and X.Bi thank the China Scholarship Council (CSC) for the scholarship support. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Electron Microscopy Facility (EMF), and by the Werner Siemens Foundation (WSS) for financial support.","language":[{"iso":"eng"}],"scopus_import":"1","date_created":"2025-08-17T22:01:37Z","OA_place":"publisher","title":"Amorphous high entropy alloy nanosheets enabling robust Li–S batteries","publication_identifier":{"issn":["1616-301X"],"eissn":["1616-3028"]},"type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1002/adfm.202513859","open_access":"1"}],"abstract":[{"lang":"eng","text":"High-entropy alloys (HEAs) show great potential for catalyzing complex multi-step reactions, but optimizing their parameters, i.e., composition, but also their crystallinity and morphology, remains a significant challenge. In this study, FeCoNiMoW HEAs are synthesized into either amorphous nanosheets (HEANS) or crystalline nanoparticles (HEANP), which are then used to catalyze the lithium–sulfur (Li–S) reaction of Li–S batteries (LSBs). Evaluations in symmetric cells, coin cells, and pouch cells reveal that HEANS significantly enhance LSB performance, achieving initial discharge capacities up to 1632 mAh g−1. The batteries also exhibit excellent cycling stability over 1000 cycles at 3Cand maintain high-rate performance up to 10C with a capacity of 614 mAh g−1. Comprehensive in situ analyses and density functional theory calculations demonstrate that amorphous HEANS provide more active sites, better ionic conductivity and stronger chemical interactions with lithium polysulfides (LiPS). These properties effectively suppress the shuttle effect, promote the complete S8 → Li2S conversion by reducing the impedance of the solid-electrolyte interphase, and accelerate the Li2S4 → Li2S2 step by lowering the nucleation energy barrier. Overall, this study highlights the superior catalytic properties of amorphous 2D HEAs in LSBs and offers new insights into the mechanisms of LiPS conversion."}],"quality_controlled":"1","author":[{"last_name":"He","first_name":"Ren","full_name":"He, Ren"},{"full_name":"Lee, Seungho","last_name":"Lee","id":"BB243B88-D767-11E9-B658-BC13E6697425","orcid":"0000-0002-6962-8598","first_name":"Seungho"},{"last_name":"Ding","first_name":"Yang","full_name":"Ding, Yang"},{"full_name":"Huang, Chen","last_name":"Huang","first_name":"Chen"},{"first_name":"Xuan","last_name":"Lu","full_name":"Lu, Xuan"},{"last_name":"Zheng","first_name":"Lirong","full_name":"Zheng, Lirong"},{"full_name":"Yu, Ao","last_name":"Yu","first_name":"Ao"},{"full_name":"Zhang, Chaoyue","last_name":"Zhang","first_name":"Chaoyue"},{"last_name":"Li","first_name":"Canhuang","full_name":"Li, Canhuang"},{"full_name":"Bi, Xiaoyu","last_name":"Bi","first_name":"Xiaoyu"},{"full_name":"Li, Yaqiang","last_name":"Li","first_name":"Yaqiang"},{"last_name":"Liao","first_name":"Yaqi","full_name":"Liao, Yaqi"},{"last_name":"Li","first_name":"Junshan","full_name":"Li, Junshan"},{"first_name":"Ahmad","last_name":"Ostovari Moghaddam","full_name":"Ostovari Moghaddam, Ahmad"},{"first_name":"Salimov","last_name":"Yernar","full_name":"Yernar, Salimov"},{"last_name":"Xu","first_name":"Ying","full_name":"Xu, Ying"},{"full_name":"Ibáñez, Maria","orcid":"0000-0001-5013-2843","first_name":"Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87","last_name":"Ibáñez"},{"full_name":"Zhang, Chaoqi","first_name":"Chaoqi","last_name":"Zhang"},{"full_name":"Yang, Linlin","first_name":"Linlin","last_name":"Yang"},{"full_name":"Zhou, Yingtang","last_name":"Zhou","first_name":"Yingtang"},{"full_name":"Cabot, Andreu","first_name":"Andreu","last_name":"Cabot"}],"department":[{"_id":"MaIb"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"has_accepted_license":"1","external_id":{"isi":["001544757200001"]},"year":"2025","citation":{"ieee":"R. He <i>et al.</i>, “Amorphous high entropy alloy nanosheets enabling robust Li–S batteries,” <i>Advanced Functional Materials</i>. Wiley, 2025.","mla":"He, Ren, et al. “Amorphous High Entropy Alloy Nanosheets Enabling Robust Li–S Batteries.” <i>Advanced Functional Materials</i>, e13859, Wiley, 2025, doi:<a href=\"https://doi.org/10.1002/adfm.202513859\">10.1002/adfm.202513859</a>.","short":"R. He, S. Lee, Y. Ding, C. Huang, X. Lu, L. Zheng, A. Yu, C. Zhang, C. Li, X. Bi, Y. Li, Y. Liao, J. Li, A. Ostovari Moghaddam, S. Yernar, Y. Xu, M. Ibáñez, C. Zhang, L. Yang, Y. Zhou, A. Cabot, Advanced Functional Materials (2025).","ista":"He R, Lee S, Ding Y, Huang C, Lu X, Zheng L, Yu A, Zhang C, Li C, Bi X, Li Y, Liao Y, Li J, Ostovari Moghaddam A, Yernar S, Xu Y, Ibáñez M, Zhang C, Yang L, Zhou Y, Cabot A. 2025. Amorphous high entropy alloy nanosheets enabling robust Li–S batteries. Advanced Functional Materials., e13859.","chicago":"He, Ren, Seungho Lee, Yang Ding, Chen Huang, Xuan Lu, Lirong Zheng, Ao Yu, et al. “Amorphous High Entropy Alloy Nanosheets Enabling Robust Li–S Batteries.” <i>Advanced Functional Materials</i>. Wiley, 2025. <a href=\"https://doi.org/10.1002/adfm.202513859\">https://doi.org/10.1002/adfm.202513859</a>.","apa":"He, R., Lee, S., Ding, Y., Huang, C., Lu, X., Zheng, L., … Cabot, A. (2025). Amorphous high entropy alloy nanosheets enabling robust Li–S batteries. <i>Advanced Functional Materials</i>. Wiley. <a href=\"https://doi.org/10.1002/adfm.202513859\">https://doi.org/10.1002/adfm.202513859</a>","ama":"He R, Lee S, Ding Y, et al. Amorphous high entropy alloy nanosheets enabling robust Li–S batteries. <i>Advanced Functional Materials</i>. 2025. doi:<a href=\"https://doi.org/10.1002/adfm.202513859\">10.1002/adfm.202513859</a>"},"month":"08","publication":"Advanced Functional Materials","acknowledged_ssus":[{"_id":"EM-Fac"}],"doi":"10.1002/adfm.202513859","status":"public","publication_status":"epub_ahead","ddc":["540"],"date_updated":"2025-09-30T14:20:56Z","project":[{"name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery","_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A"}],"article_processing_charge":"Yes (in subscription journal)","day":"06","oa_version":"Published Version","OA_type":"hybrid","oa":1},{"publication":"The Open Journal of Astrophysics","month":"07","year":"2025","citation":{"short":"H. Katz, A.J. Cameron, A. Saxena, L. Barrufet, N. Choustikov, N.J. Cleri, A. De Graaff, R.S. Ellis, R.A.E. Fosbury, K.E. Heintz, M. Maseda, J.J. Matthee, I. Mcconachie, P.A. Oesch, The Open Journal of Astrophysics 8 (2025).","mla":"Katz, Harley, et al. “21 Balmer Jump Street: The Nebular Continuum at High Redshift and Implications for the Bright Galaxy Problem, UV Continuum Slopes, and Early Stellar Populations.” <i>The Open Journal of Astrophysics</i>, vol. 8, Maynooth Academic Publishing, 2025, doi:<a href=\"https://doi.org/10.33232/001c.142570\">10.33232/001c.142570</a>.","ista":"Katz H, Cameron AJ, Saxena A, Barrufet L, Choustikov N, Cleri NJ, De Graaff A, Ellis RS, Fosbury RAE, Heintz KE, Maseda M, Matthee JJ, Mcconachie I, Oesch PA. 2025. 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. The Open Journal of Astrophysics. 8.","chicago":"Katz, Harley, Alex J. Cameron, Aayush Saxena, Laia Barrufet, Nicholas Choustikov, Nikko J. Cleri, Anna De Graaff, et al. “21 Balmer Jump Street: The Nebular Continuum at High Redshift and Implications for the Bright Galaxy Problem, UV Continuum Slopes, and Early Stellar Populations.” <i>The Open Journal of Astrophysics</i>. Maynooth Academic Publishing, 2025. <a href=\"https://doi.org/10.33232/001c.142570\">https://doi.org/10.33232/001c.142570</a>.","ama":"Katz H, Cameron AJ, Saxena A, et al. 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. <i>The Open Journal of Astrophysics</i>. 2025;8. doi:<a href=\"https://doi.org/10.33232/001c.142570\">10.33232/001c.142570</a>","apa":"Katz, H., Cameron, A. J., Saxena, A., Barrufet, L., Choustikov, N., Cleri, N. J., … Oesch, P. A. (2025). 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. <i>The Open Journal of Astrophysics</i>. Maynooth Academic Publishing. <a href=\"https://doi.org/10.33232/001c.142570\">https://doi.org/10.33232/001c.142570</a>","ieee":"H. Katz <i>et al.</i>, “21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations,” <i>The Open Journal of Astrophysics</i>, vol. 8. Maynooth Academic Publishing, 2025."},"external_id":{"arxiv":["2408.03189"]},"has_accepted_license":"1","oa":1,"OA_type":"diamond","oa_version":"Published Version","volume":8,"article_processing_charge":"No","day":"25","file":[{"content_type":"application/pdf","date_updated":"2025-09-30T14:28:25Z","file_size":1836432,"creator":"dernst","relation":"main_file","access_level":"open_access","checksum":"ba469d132907147f9e86d87f9124dd14","success":1,"file_id":"20412","file_name":"2025_OpenJourAstrophysics_Katz.pdf","date_created":"2025-09-30T14:28:25Z"}],"file_date_updated":"2025-09-30T14:28:25Z","date_updated":"2025-09-30T14:29:33Z","ddc":["520"],"publication_status":"published","status":"public","PlanS_conform":"1","doi":"10.33232/001c.142570","OA_place":"publisher","date_created":"2025-08-17T22:01:37Z","scopus_import":"1","language":[{"iso":"eng"}],"acknowledgement":"HK thanks Andrey Kravtsov for insightful comments and thoughtful discussions. We sincerely thank the PIs and Co-Is of the JWST programs where spectral data was made publicly available on the DJA. We refer interested readers to the following papers for survey descriptions regarding the spectral data: Bunker et al. (2023a); D’Eugenio et al. (2024); Bezanson et al. (2022); Barrufet et al. (2024); de Graaff et al. (2024); Finkelstein et al. (2024); Glazebrook et al. (2024); Pierel et al. (2024); Siebert et al. (2024); Maseda et al. (2024). This work is based in part on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs listed in Table 1. AJC and AS acknowledge funding from the “FirstGalaxies” Advanced Grant from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 789056). ","date_published":"2025-07-25T00:00:00Z","_id":"20192","intvolume":"         8","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Maynooth Academic Publishing","article_type":"original","department":[{"_id":"JoMa"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"author":[{"full_name":"Katz, Harley","last_name":"Katz","first_name":"Harley"},{"first_name":"Alex J.","last_name":"Cameron","full_name":"Cameron, Alex J."},{"full_name":"Saxena, Aayush","first_name":"Aayush","last_name":"Saxena"},{"full_name":"Barrufet, Laia","last_name":"Barrufet","first_name":"Laia"},{"last_name":"Choustikov","first_name":"Nicholas","full_name":"Choustikov, Nicholas"},{"first_name":"Nikko J.","last_name":"Cleri","full_name":"Cleri, Nikko J."},{"last_name":"De Graaff","first_name":"Anna","full_name":"De Graaff, Anna"},{"full_name":"Ellis, Richard S.","first_name":"Richard S.","last_name":"Ellis"},{"first_name":"Robert A.E.","last_name":"Fosbury","full_name":"Fosbury, Robert A.E."},{"last_name":"Heintz","first_name":"Kasper E.","full_name":"Heintz, Kasper E."},{"full_name":"Maseda, Michael","last_name":"Maseda","first_name":"Michael"},{"first_name":"Jorryt J","orcid":"0000-0003-2871-127X","id":"7439a258-f3c0-11ec-9501-9df22fe06720","last_name":"Matthee","full_name":"Matthee, Jorryt J"},{"last_name":"Mcconachie","first_name":"Ian","full_name":"Mcconachie, Ian"},{"full_name":"Oesch, Pascal A.","first_name":"Pascal A.","last_name":"Oesch"}],"quality_controlled":"1","abstract":[{"lang":"eng","text":"We study the physical origin and spectroscopic impact of extreme nebular emission in high-redshift galaxies. The nebular continuum, which can appear during an extreme starburst, is of particular importance as it tends to redden UV slopes and has a significant contribution to the UV luminosities of galaxies. Furthermore, its shape can be used to infer the gas density and temperature of the interstellar medium. First, we provide a theoretical background, showing how different stellar populations (SPS models, initial mass functions (IMFs), and stellar temperatures) and nebular conditions impact observed galaxy spectra. We demonstrate that, for systems with strong nebular continuum emission, 1) UV fluxes can increase by up to 0.7~mag (or more in the case of hot/massive stars) above the stellar continuum, which may help reconcile the surprising abundance of bright high-redshift galaxies and the elevated UV luminosity density at z>10, 2) at high gas densities, UV slopes can redden from \\beta<-2.5 to \\beta\\sim-1, 3) observational measurements of \\xi_{\\rm ion} are gross underestimates, and 4) UV downturns from two-photon emission can masquerade as damped Ly\\alpha systems. Second, we present a dataset of 58 galaxies observed with NIRSpec on JWST at 2.5<z<9.0 that are selected to have strong nebular continuum emission via the detection of the Balmer jump. Five of the 58 spectra are consistent with being dominated by nebular emission, exhibiting both a Balmer jump and a UV downturn consistent with two-photon emission. For some galaxies, this may imply the presence of hot massive stars and a top-heavy IMF. We conclude by exploring the properties of spectroscopically confirmed z>10 galaxies, finding that UV slopes and UV downturns are in some cases redder or steeper than expected from SPS models, which may hint at more exotic (e.g. hotter/more massive stars or AGN) ionizing sources."}],"type":"journal_article","publication_identifier":{"eissn":["2565-6120"]},"arxiv":1,"title":"21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations"}]