[{"oa":1,"date_updated":"2026-06-16T10:47:41Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_type":"original","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","_id":"21342","citation":{"apa":"Naidu, R. P., Oesch, P. A., Brammer, G., Weibel, A., Li, Y., Matthee, J. J., … Whitaker, K. E. (2026). A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST. The Open Journal of Astrophysics. Maynooth Academic Publishing. https://doi.org/10.33232/001c.156033","mla":"Naidu, Rohan P., et al. “A Cosmic Miracle: A Remarkably Luminous Galaxy at Zspec = 14.44 Confirmed with JWST.” The Open Journal of Astrophysics, vol. 9, Maynooth Academic Publishing, 2026, doi:10.33232/001c.156033.","ama":"Naidu RP, Oesch PA, Brammer G, et al. A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST. The Open Journal of Astrophysics. 2026;9. doi:10.33232/001c.156033","chicago":"Naidu, Rohan P., Pascal A. Oesch, Gabriel Brammer, Andrea Weibel, Yijia Li, Jorryt J Matthee, John Chisholm, et al. “A Cosmic Miracle: A Remarkably Luminous Galaxy at Zspec = 14.44 Confirmed with JWST.” The Open Journal of Astrophysics. Maynooth Academic Publishing, 2026. https://doi.org/10.33232/001c.156033.","ista":"Naidu RP, Oesch PA, Brammer G, Weibel A, Li Y, Matthee JJ, Chisholm J, Pollock CL, Heintz KE, Johnson BD, Shen X, Hviding RE, Leja J, Tacchella S, Ganguly A, Witten C, Atek H, Belli S, Bose S, Bouwens R, Dayal P, Decarli R, De Graaff A, Fudamoto Y, Giovinazzo E, Greene JE, Illingworth G, Inoue AK, Kane SG, Labbe I, Leonova E, Marques-Chaves R, Meyer RA, Nelson EJ, Roberts-Borsani G, Schaerer D, Simcoe RA, Stefanon M, Sugahara Y, Toft S, Van Der Wel A, Van Dokkum P, Walter F, Watson D, Weaver JR, Whitaker KE. 2026. A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST. The Open Journal of Astrophysics. 9.","ieee":"R. P. Naidu et al., “A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST,” The Open Journal of Astrophysics, vol. 9. Maynooth Academic Publishing, 2026.","short":"R.P. Naidu, P.A. Oesch, G. Brammer, A. Weibel, Y. Li, J.J. Matthee, J. Chisholm, C.L. Pollock, K.E. Heintz, B.D. Johnson, X. Shen, R.E. Hviding, J. Leja, S. Tacchella, A. Ganguly, C. Witten, H. Atek, S. Belli, S. Bose, R. Bouwens, P. Dayal, R. Decarli, A. De Graaff, Y. Fudamoto, E. Giovinazzo, J.E. Greene, G. Illingworth, A.K. Inoue, S.G. Kane, I. Labbe, E. Leonova, R. Marques-Chaves, R.A. Meyer, E.J. Nelson, G. Roberts-Borsani, D. Schaerer, R.A. Simcoe, M. Stefanon, Y. Sugahara, S. Toft, A. Van Der Wel, P. Van Dokkum, F. Walter, D. Watson, J.R. Weaver, K.E. Whitaker, The Open Journal of Astrophysics 9 (2026)."},"acknowledgement":"We thank the two anonymous referees for their insightful comments that have strengthened this work. “Mirage or Miracle” is but the latest link in a long chain of surveys that have built COSMOS into a premier extragalactic legacy field. We are thankful to all the teams who have contributed to this legacy, particularly those mentioned in §3 for leading recent JWST programs whose imaging\r\nwe have incorporated in our analysis. We are grateful to Vasily Belokurov for help in compiling the Milky Way reference sample featured in Fig 8. We thank Danielle Berg for sharing a highly complete, highly decimalized NUV vacuum line list. We are grateful to our program’s NIRSpec reviewer, Dan Coe, and program coordinator, Allison Vick, for valuable input on our MSA design. We acknowledge illuminating conversations with Risa Wechsler and Chao-Lin Kuo about early reionization. RPN thanks Neil Pappalardo and Jane Pappalardo for their generous support of the MIT Pappalardo Fellowships in Physics, and for their enthusiasm and encouragement for seeking galaxies at the highest redshifts. RPN acknowledges funding from JWST program GO5224. Support for this work was provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss National Science Foundation (SNSF) through project grant 200020 207349. Funded by the European Union (ERC, AGENTS, 101076224 and HEAVYMETAL, 101071865). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of\r\nthe European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant DNRF140. This work has also been supported by JSPS KAKENHI Grant Number 23H00131. HA acknowledges support from CNES, focused on the JWST mission, and the Programme National Cosmology and Galaxies (PNCG)\r\nof CNRS/INSU with INP and IN2P3, co-funded by CEA and CNES. HA is supported by the French National Research Agency (ANR) under the project FIRSTGAL, grant number ANR-24-CE31-0838. SB is supported by the UK Research and Innovation (UKRI) Future Leaders Fellowship [grant number MR/V023381/1]. R.D. acknowledges support from the INAF GO 2022\r\ngrant “The birth of the giants: JWST sheds light on the build-up of quasars at cosmic dawn” and by the PRIN MUR “2022935STW”, RFF M4.C2.1.1, CUP J53D23001570006 and C53D23000950006. Computations supporting this paper were run on MIT’s Engaging cluster. This publication made use of the NASA Astrophysical Data System for bibliographic information. Some of the data products presented herein were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN), which is funded by the Danish National Research Foundation under grant DNRF140. Software used in developing this work includes: matplotlib (Hunter 2007), jupyter (Kluyver et al. 2016), IPython (P´erez & Granger 2007), numpy (Oliphant 2015), scipy (Virtanen et al. 2020), TOPCAT (Taylor 2005), and Astropy (Astropy Collaboration et al. 2013).This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space\r\nTelescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with program # 5224.","author":[{"full_name":"Naidu, Rohan P.","first_name":"Rohan P.","last_name":"Naidu"},{"first_name":"Pascal A.","full_name":"Oesch, Pascal A.","last_name":"Oesch"},{"full_name":"Brammer, Gabriel","first_name":"Gabriel","last_name":"Brammer"},{"last_name":"Weibel","first_name":"Andrea","full_name":"Weibel, Andrea"},{"first_name":"Yijia","full_name":"Li, Yijia","last_name":"Li"},{"id":"7439a258-f3c0-11ec-9501-9df22fe06720","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","full_name":"Matthee, Jorryt J","last_name":"Matthee"},{"last_name":"Chisholm","first_name":"John","full_name":"Chisholm, John"},{"first_name":"Clara L.","full_name":"Pollock, Clara L.","last_name":"Pollock"},{"first_name":"Kasper E.","full_name":"Heintz, Kasper E.","last_name":"Heintz"},{"full_name":"Johnson, Benjamin D.","first_name":"Benjamin D.","last_name":"Johnson"},{"last_name":"Shen","full_name":"Shen, Xuejian","first_name":"Xuejian"},{"first_name":"Raphael E.","full_name":"Hviding, Raphael E.","last_name":"Hviding"},{"first_name":"Joel","full_name":"Leja, Joel","last_name":"Leja"},{"last_name":"Tacchella","first_name":"Sandro","full_name":"Tacchella, Sandro"},{"first_name":"Arpita","full_name":"Ganguly, Arpita","last_name":"Ganguly"},{"last_name":"Witten","first_name":"Callum","full_name":"Witten, Callum"},{"last_name":"Atek","first_name":"Hakim","full_name":"Atek, Hakim"},{"last_name":"Belli","first_name":"Sirio","full_name":"Belli, Sirio"},{"first_name":"Sownak","full_name":"Bose, Sownak","last_name":"Bose"},{"first_name":"Rychard","full_name":"Bouwens, Rychard","last_name":"Bouwens"},{"first_name":"Pratika","full_name":"Dayal, Pratika","last_name":"Dayal"},{"full_name":"Decarli, Roberto","first_name":"Roberto","last_name":"Decarli"},{"last_name":"De Graaff","first_name":"Anna","full_name":"De Graaff, Anna"},{"last_name":"Fudamoto","full_name":"Fudamoto, Yoshinobu","first_name":"Yoshinobu"},{"last_name":"Giovinazzo","full_name":"Giovinazzo, Emma","first_name":"Emma"},{"last_name":"Greene","full_name":"Greene, Jenny E.","first_name":"Jenny E."},{"last_name":"Illingworth","first_name":"Garth","full_name":"Illingworth, Garth"},{"last_name":"Inoue","first_name":"Akio K.","full_name":"Inoue, Akio K."},{"last_name":"Kane","full_name":"Kane, Sarah G.","first_name":"Sarah G."},{"first_name":"Ivo","full_name":"Labbe, Ivo","last_name":"Labbe"},{"last_name":"Leonova","first_name":"Ecaterina","full_name":"Leonova, Ecaterina"},{"full_name":"Marques-Chaves, Rui","first_name":"Rui","last_name":"Marques-Chaves"},{"full_name":"Meyer, Romain A.","first_name":"Romain A.","last_name":"Meyer"},{"full_name":"Nelson, Erica J.","first_name":"Erica J.","last_name":"Nelson"},{"full_name":"Roberts-Borsani, Guido","first_name":"Guido","last_name":"Roberts-Borsani"},{"first_name":"Daniel","full_name":"Schaerer, Daniel","last_name":"Schaerer"},{"full_name":"Simcoe, Robert A.","first_name":"Robert A.","last_name":"Simcoe"},{"first_name":"Mauro","full_name":"Stefanon, Mauro","last_name":"Stefanon"},{"full_name":"Sugahara, Yuma","first_name":"Yuma","last_name":"Sugahara"},{"full_name":"Toft, Sune","first_name":"Sune","last_name":"Toft"},{"last_name":"Van Der Wel","first_name":"Arjen","full_name":"Van Der Wel, Arjen"},{"last_name":"Van Dokkum","full_name":"Van Dokkum, Pieter","first_name":"Pieter"},{"last_name":"Walter","full_name":"Walter, Fabian","first_name":"Fabian"},{"full_name":"Watson, Darach","first_name":"Darach","last_name":"Watson"},{"first_name":"John R.","full_name":"Weaver, John R.","last_name":"Weaver"},{"last_name":"Whitaker","full_name":"Whitaker, Katherine E.","first_name":"Katherine E."}],"project":[{"grant_number":"101076224","_id":"bd9b2118-d553-11ed-ba76-db24564edfea","name":"Young galaxies as tracers and agents of cosmic reionization"}],"ddc":["520"],"publication_identifier":{"eissn":["2565-6120"]},"external_id":{"arxiv":["2505.11263"]},"date_created":"2026-02-22T23:01:35Z","oa_version":"Published Version","month":"01","language":[{"iso":"eng"}],"publisher":"Maynooth Academic Publishing","date_published":"2026-01-30T00:00:00Z","doi":"10.33232/001c.156033","type":"journal_article","intvolume":" 9","PlanS_conform":"1","status":"public","abstract":[{"lang":"eng","text":"JWST has revealed a stunning population of bright galaxies at surprisingly early epochs, z > 10,\r\nwhere few such sources were expected. Here we present the most distant example of this class yet – MoM-z14, a luminous (MUV = −20.2) source in the COSMOS legacy field at zspec = 14.44+0.02−0.02 that expands the observational frontier to a mere 280 million years after the Big Bang. The redshift is confirmed with NIRSpec/prism spectroscopy through a sharp Lyman-α break and ≈ 3σ detections of five rest-UV emission lines. The number density of bright zspec ≈ 14 − 15 sources implied by our “Mirage or Miracle” survey spanning ≈ 350 arcmin2 is > 100× larger (182+329 −105×) than pre-JWST consensus models. The high EWs of UV lines (≈15−35˚A) signal a rising star-formation history, with a ≈10× increase in the last 5 Myr (SFR5Myr/SFR50Myr = 9.9 +3.0 −5.8). The source is extremely compact (circularized re = 74+15\r\n−12 pc), and yet elongated (b/a = 0.25+0.11−0.06), suggesting an AGN is not the dominant source of UV light. The steep UV slope (β = −2.5 +0.2 −0.2) implies negligible dust attenuation\r\nand a young stellar population. The absence of a strong damping wing provides tentative evidence that the immediate surroundings of MoM-z14 may be partially ionized at a redshift where virtually every reionization model predicts a ≈ 100% neutral fraction. The nitrogen emission and highly supersolar [N/C]> 1 hint at an abundance pattern similar to local globular clusters that may have once hosted luminous supermassive stars. Since this abundance pattern is also common among the most ancient stars born in the Milky Way, we may be directly witnessing the formation of such stars in dense clusters, connecting galaxy evolution across the entire sweep of cosmic time. "}],"publication_status":"published","license":"https://creativecommons.org/licenses/by/4.0/","article_processing_charge":"No","publication":"The Open Journal of Astrophysics","day":"30","has_accepted_license":"1","title":"A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed with JWST","year":"2026","scopus_import":"1","OA_type":"diamond","arxiv":1,"department":[{"_id":"JoMa"}],"volume":9,"main_file_link":[{"url":"https://doi.org/10.33232/001c.156033","open_access":"1"}]},{"abstract":[{"text":"Tropospheric ozone has the potential to become an increasingly pressing public health issue in Bogotá, Colombia, due to rising concentrations across the city driven by complex interactions among emissions, meteorology, and urban structure. This study presents a comprehensive spatiotemporal analysis of ozone levels from 2013 to 2023 and assesses the associated health burden using mortality data from the same period. Results reveal a consistent upward trend in ozone concentrations, particularly in northern, western, and southern localities, with seasonal peaks linked to biomass burning and photochemical conditions. Mortality analysis, based on the Global Exposure Mortality Model, estimates that 18.3% of all deaths among individuals aged 25 and older are attributable to long-term ozone exposure. The highest burdens are found in densely populated and socioeconomically vulnerable areas such as Kennedy, Suba, and Ciudad Bolívar, with the elderly being the most affected. Building on these findings, we developed a machine learning prediction model for ozone using a convolutional merge with a long-short term memory network architecture trained on air quality and meteorological variables. The model demonstrated strong predictive performance (mean Rho=0.86, RMSE=3.5 μg/m3) across monitoring stations (17 with at least 35000 data points), supporting its potential application in real-time early warning systems across Bogotá. This integrated approach highlights the importance of localized air quality management, combining epidemiological assessment with predictive modeling. The findings underscore the urgency of implementing region-specific mitigation strategies and improving monitoring infrastructure to reduce health risks from ozone exposure in Bogotá’s rapidly growing urban environment.","lang":"eng"}],"publication_status":"epub_ahead","status":"public","PlanS_conform":"1","article_processing_charge":"Yes (via OA deal)","year":"2026","has_accepted_license":"1","title":"Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia","day":"20","publication":"Earth Systems and Environment","main_file_link":[{"url":"https://doi.org/10.1007/s41748-026-01052-3","open_access":"1"}],"department":[{"_id":"CaMu"}],"ec_funded":1,"OA_type":"hybrid","corr_author":"1","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"article_type":"original","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_updated":"2026-02-24T08:02:58Z","author":[{"first_name":"Daniela","full_name":"Bustos, Daniela","last_name":"Bustos"},{"last_name":"Garcia","full_name":"Garcia, Diana","first_name":"Diana"},{"first_name":"Nestor Y.","full_name":"Rojas, Nestor Y.","last_name":"Rojas"},{"first_name":"Ellie A.","full_name":"Lopez-Barrera, Ellie A.","last_name":"Lopez-Barrera"},{"last_name":"Peña-Rincon","first_name":"Carlos","full_name":"Peña-Rincon, Carlos"},{"orcid":"0000-0002-1988-5035","last_name":"Casallas Garcia","full_name":"Casallas Garcia, Alejandro","first_name":"Alejandro","id":"92081129-2d75-11ef-a48d-b04dd7a2385a"}],"acknowledgement":"EAL-B and CP-R received support from Sergio Arboleda University through project No. IN.BG.086.24.014. AC acknowledges support by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034413. We thank two anonymous reviewers for thein insightful comments that largely improve the manuscript. Open access funding provided by Institute of Science and Technology (IST Austria). This work was funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034413. The work also received funding from Sergio Arboleda University through project No. IN.BG.086.24.014.","citation":{"short":"D. Bustos, D. Garcia, N.Y. Rojas, E.A. Lopez-Barrera, C. Peña-Rincon, A. Casallas Garcia, Earth Systems and Environment (2026).","ieee":"D. Bustos, D. Garcia, N. Y. Rojas, E. A. Lopez-Barrera, C. Peña-Rincon, and A. Casallas Garcia, “Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia,” Earth Systems and Environment. Springer Nature, 2026.","chicago":"Bustos, Daniela, Diana Garcia, Nestor Y. Rojas, Ellie A. Lopez-Barrera, Carlos Peña-Rincon, and Alejandro Casallas Garcia. “Ozone Trends and Mortality Risk: The Growing Need for Machine Learning Predictions in Bogotá, Colombia.” Earth Systems and Environment. Springer Nature, 2026. https://doi.org/10.1007/s41748-026-01052-3.","ama":"Bustos D, Garcia D, Rojas NY, Lopez-Barrera EA, Peña-Rincon C, Casallas Garcia A. Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia. Earth Systems and Environment. 2026. doi:10.1007/s41748-026-01052-3","ista":"Bustos D, Garcia D, Rojas NY, Lopez-Barrera EA, Peña-Rincon C, Casallas Garcia A. 2026. Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia. Earth Systems and Environment.","mla":"Bustos, Daniela, et al. “Ozone Trends and Mortality Risk: The Growing Need for Machine Learning Predictions in Bogotá, Colombia.” Earth Systems and Environment, Springer Nature, 2026, doi:10.1007/s41748-026-01052-3.","apa":"Bustos, D., Garcia, D., Rojas, N. Y., Lopez-Barrera, E. A., Peña-Rincon, C., & Casallas Garcia, A. (2026). Ozone trends and mortality risk: The growing need for machine learning predictions in Bogotá, Colombia. Earth Systems and Environment. Springer Nature. https://doi.org/10.1007/s41748-026-01052-3"},"_id":"21344","OA_place":"publisher","month":"02","date_created":"2026-02-23T08:26:51Z","oa_version":"Published Version","project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020","grant_number":"101034413"}],"ddc":["550"],"publication_identifier":{"eissn":["2509-9434"],"issn":["2509-9426"]},"doi":"10.1007/s41748-026-01052-3","type":"journal_article","date_published":"2026-02-20T00:00:00Z","publisher":"Springer Nature","language":[{"iso":"eng"}]},{"article_processing_charge":"No","license":"https://creativecommons.org/licenses/by-sa/4.0/","page":"185","publication_status":"published","file":[{"creator":"sriegler","file_id":"21386","access_level":"closed","content_type":"application/x-zip-compressed","file_name":"2026_Riegler_Stefan_Thesis.zip","date_created":"2026-03-02T10:59:50Z","checksum":"2f1f44e8536c2538f94a440217452c9f","file_size":31430022,"relation":"source_file","date_updated":"2026-03-02T10:59:50Z"},{"file_size":11635090,"relation":"main_file","date_updated":"2026-03-02T10:59:49Z","checksum":"2e8dc39640bc26ae5684c944c619719b","embargo":"2027-02-27","embargo_to":"open_access","file_name":"2026_Riegler_Stefan_Thesis.pdf","date_created":"2026-03-02T10:59:49Z","content_type":"application/pdf","access_level":"closed","file_id":"21387","creator":"sriegler"}],"status":"public","department":[{"_id":"GradSch"},{"_id":"EvBe"}],"alternative_title":["ISTA Thesis"],"degree_awarded":"PhD","year":"2026","has_accepted_license":"1","title":"Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea species","day":"26","author":[{"id":"FF6018E0-D806-11E9-8E43-0B14E6697425","full_name":"Riegler, Stefan","first_name":"Stefan","last_name":"Riegler","orcid":"0000-0003-3413-1343"}],"acknowledgement":"I would like to acknowledge the Austrian Academy of Sciences (ÖAW) and European\r\nResearch Executive Agency (REA) for funding my research (DOC ÖAW Fellowship\r\n26130, Horizon Europe BOLERO Project 101060393). ","citation":{"ieee":"S. Riegler, “Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species,” Institute of Science and Technology Austria, 2026.","short":"S. Riegler, Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species, Institute of Science and Technology Austria, 2026.","apa":"Riegler, S. (2026). Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21360","mla":"Riegler, Stefan. Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21360.","ista":"Riegler S. 2026. 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First, contrasting nitrogen supply, second, intra- and interspecific grafting."}],"file":[{"file_id":"21364","creator":"sriegler","access_level":"closed","file_name":"SupplementaryTables.xlsx","date_created":"2026-02-27T09:11:33Z","embargo_to":"open_access","content_type":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","relation":"main_file","file_size":63749444,"date_updated":"2026-02-27T09:11:33Z","embargo":"2027-02-27","checksum":"de9145fa166a28c588b5184a2d3d4fee"},{"date_created":"2026-02-27T09:13:11Z","file_name":"ReadMe.txt","embargo_to":"open_access","content_type":"text/plain","relation":"main_file","file_size":124,"date_updated":"2026-02-27T09:13:11Z","embargo":"2027-02-27","checksum":"ce1f163551c96cee45943a8ea29720b6","file_id":"21365","creator":"sriegler","access_level":"closed"}],"date_updated":"2026-06-10T09:39:13Z","tmp":{"image":"/images/cc_by_sa.png","short":"CC BY-SA (4.0)","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode"},"citation":{"ieee":"S. Riegler, “Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea  species.” Institute of Science and Technology Austria, 2026.","short":"S. Riegler, (2026).","mla":"Riegler, Stefan. Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21363.","apa":"Riegler, S. (2026). Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea  species. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21363","chicago":"Riegler, Stefan. “Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21363.","ista":"Riegler S. 2026. Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea  species, Institute of Science and Technology Austria, 10.15479/AT-ISTA-21363.","ama":"Riegler S. Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea  species. 2026. doi:10.15479/AT-ISTA-21363"},"article_processing_charge":"No","author":[{"id":"FF6018E0-D806-11E9-8E43-0B14E6697425","orcid":"0000-0003-3413-1343","full_name":"Riegler, Stefan","first_name":"Stefan","last_name":"Riegler"}],"contributor":[{"contributor_type":"supervisor","orcid":"0000-0002-8510-9739","last_name":"Benková","first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87"}],"_id":"21363","title":"Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea species","has_accepted_license":"1","oa_version":"Published Version","date_created":"2026-02-27T09:18:41Z","year":"2026","month":"02","ddc":["575"],"day":"27","file_date_updated":"2026-02-27T09:13:11Z","doi":"10.15479/AT-ISTA-21363","type":"research_data","department":[{"_id":"GradSch"},{"_id":"EvBe"}],"related_material":{"record":[{"status":"public","id":"21360","relation":"used_in_publication"}]},"date_published":"2026-02-27T00:00:00Z","publisher":"Institute of Science and Technology Austria"},{"article_processing_charge":"Yes","PlanS_conform":"1","intvolume":" 17","status":"public","file":[{"date_created":"2026-03-02T09:34:18Z","file_name":"2026_NatureComm_Hu.pdf","success":1,"content_type":"application/pdf","date_updated":"2026-03-02T09:34:18Z","relation":"main_file","file_size":4821073,"checksum":"fa2b55b3a0d8978de7d2d061c7ad8779","file_id":"21377","creator":"dernst","access_level":"open_access"}],"publication_status":"published","abstract":[{"text":"Formation of new amyloid fibrils and oligomers from monomeric protein on the surfaces of existing fibrils is an important driver of many disorders such as Alzheimer’s and Parkinson’s diseases. The structural basis of this secondary nucleation process, however, is poorly understood. Here, we ask whether secondary nucleation sites are found predominantly at rare growth defects: irregularities in the fibril core structure incorporated during their original assembly. We first demonstrate using the specific inhibitor of secondary nucleation, Brichos, that secondary nucleation sites on Alzheimer’s disease-associated fibrils composed of Aβ40 and Aβ42 peptides are rare compared to the number of protein molecules they contain. We then grow Aβ40 fibrils under conditions designed to eliminate most growth defects while leaving the regular fibril morphology unchanged, and confirm the latter using cryo-electron microscopy. We measure both the ability of these annealed fibrils to promote secondary nucleation and the stoichiometry of their secondary nucleation sites, finding that both are greatly reduced as predicted. Re-analysis of published data for other proteins suggests that fibril growth defects may also drive secondary nucleation generally across most amyloids. These findings could unlock structure-based drug design of therapeutics that aim to halt amyloid disorders by inhibiting secondary nucleation sites.","lang":"eng"}],"OA_type":"gold","ec_funded":1,"volume":17,"article_number":"1933","department":[{"_id":"AnSa"}],"publication":"Nature Communications","day":"20","has_accepted_license":"1","title":"Structural defects in amyloid-β fibrils drive secondary nucleation","year":"2026","scopus_import":"1","OA_place":"publisher","DOAJ_listed":"1","_id":"21369","acknowledgement":"This work was supported by the Swedish Research Council (2019-02397 to E.S., 2015-00143 to S.L., and 2022-06641 to S.L. and E.S.), and the GenerationNano project, the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 945378 (S.L. co-PI). We acknowledge support from the Wellcome Trust (T.P.J.K.), the Cambridge Centre for Misfolding Diseases (T.P.J.K.), the BBSRC (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the ERC PhysProt (agreement n 337969) (T.S., T.P.J.K., S.L.), ETC StG “NEPA” (A.Š. and S.C.), the Royal Society (S.C., A.S.), the ERASMUS Programme (T.S.), and The Danish Council for Independent Research ∣ Natural Sciences (FNU-11-113326) (M.A.). This work was also funded by the Novo Nordisk Foundation (#NNF19OC0054635 to S.L.), ETH Zürich (T.C.T.M.), and the Swiss National Science Foundation (grant no 219703 to A.J.D. and T.C.T.M.). We acknowledge the use of the nano-Characterisation and nano-Manufacturing Research Equipment (nCHREM) facility for access to microscopy instrumentation. We are grateful to the late Professor Sir Christopher Dobson for invaluable conversations regarding the microfluidic diffusional sizing experiments. We are also grateful to Quentin A. E. Peter and Thomas Müller for their guidance on microfluidic device design. The cuvette-filled icon in Fig. 3d is by Servier [https://smart.servier.com/]. It is licensed under CC-BY 3.0 Unported [https://creativecommons.org/licenses/by/3.0/]. The authors would like to acknowledge Umeå Centre for Electron Microscopy (UCEM) for technical assistance and access to electron microscopy. Support was provided by SciLifeLab national Cryo-EM Unit at Umeå University.","citation":{"apa":"Hu, J., Scheidt, T., Thacker, D., Axell, E., Stemme, E., Łapińska, U., … Dear, A. J. (2026). Structural defects in amyloid-β fibrils drive secondary nucleation. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-69377-1","mla":"Hu, Jing, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary Nucleation.” Nature Communications, vol. 17, 1933, Springer Nature, 2026, doi:10.1038/s41467-026-69377-1.","chicago":"Hu, Jing, Tom Scheidt, Dev Thacker, Emil Axell, Elin Stemme, Urszula Łapińska, Stefan Wennmalm, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary Nucleation.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-69377-1.","ama":"Hu J, Scheidt T, Thacker D, et al. Structural defects in amyloid-β fibrils drive secondary nucleation. Nature Communications. 2026;17. doi:10.1038/s41467-026-69377-1","ista":"Hu J, Scheidt T, Thacker D, Axell E, Stemme E, Łapińska U, Wennmalm S, Meisl G, Curk S, Andreasen M, Vendruscolo M, Arosio P, Šarić A, Schmit JD, Knowles TPJ, Sparr E, Linse S, Michaels TCT, Dear AJ. 2026. Structural defects in amyloid-β fibrils drive secondary nucleation. Nature Communications. 17, 1933.","ieee":"J. Hu et al., “Structural defects in amyloid-β fibrils drive secondary nucleation,” Nature Communications, vol. 17. Springer Nature, 2026.","short":"J. Hu, T. Scheidt, D. Thacker, E. Axell, E. Stemme, U. Łapińska, S. Wennmalm, G. Meisl, S. Curk, M. Andreasen, M. Vendruscolo, P. Arosio, A. Šarić, J.D. Schmit, T.P.J. Knowles, E. Sparr, S. Linse, T.C.T. Michaels, A.J. Dear, Nature Communications 17 (2026)."},"pmid":1,"author":[{"last_name":"Hu","first_name":"Jing","full_name":"Hu, Jing"},{"last_name":"Scheidt","first_name":"Tom","full_name":"Scheidt, Tom"},{"last_name":"Thacker","first_name":"Dev","full_name":"Thacker, Dev"},{"last_name":"Axell","full_name":"Axell, Emil","first_name":"Emil"},{"full_name":"Stemme, Elin","first_name":"Elin","last_name":"Stemme"},{"first_name":"Urszula","full_name":"Łapińska, Urszula","last_name":"Łapińska"},{"full_name":"Wennmalm, Stefan","first_name":"Stefan","last_name":"Wennmalm"},{"full_name":"Meisl, Georg","first_name":"Georg","last_name":"Meisl"},{"id":"031eff0d-d481-11ee-8508-cd12a7a86e5b","orcid":"0000-0001-6160-9766","last_name":"Curk","first_name":"Samo","full_name":"Curk, Samo"},{"last_name":"Andreasen","full_name":"Andreasen, Maria","first_name":"Maria"},{"last_name":"Vendruscolo","full_name":"Vendruscolo, Michele","first_name":"Michele"},{"first_name":"Paolo","full_name":"Arosio, Paolo","last_name":"Arosio"},{"id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139","last_name":"Šarić","first_name":"Anđela","full_name":"Šarić, Anđela"},{"full_name":"Schmit, Jeremy D.","first_name":"Jeremy D.","last_name":"Schmit"},{"last_name":"Knowles","full_name":"Knowles, Tuomas P.J.","first_name":"Tuomas P.J."},{"last_name":"Sparr","first_name":"Emma","full_name":"Sparr, Emma"},{"last_name":"Linse","full_name":"Linse, Sara","first_name":"Sara"},{"last_name":"Michaels","full_name":"Michaels, Thomas C.T.","first_name":"Thomas C.T."},{"last_name":"Dear","first_name":"Alexander J.","full_name":"Dear, Alexander J."}],"oa":1,"article_type":"original","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_updated":"2026-03-02T09:36:48Z","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"date_published":"2026-02-20T00:00:00Z","publisher":"Springer Nature","doi":"10.1038/s41467-026-69377-1","file_date_updated":"2026-03-02T09:34:18Z","type":"journal_article","project":[{"_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines","call_identifier":"H2020","grant_number":"802960"}],"ddc":["570"],"publication_identifier":{"eissn":["2041-1723"]},"external_id":{"pmid":["41708600"]},"oa_version":"Published Version","date_created":"2026-03-01T23:01:38Z","month":"02"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_updated":"2026-03-23T13:18:11Z","article_type":"original","issue":"1","citation":{"ista":"Volpe G, Wählby C, Tian L, Hecht M, Yakimovich A, Monakhova K, Waller L, Sbalzarini IF, Metzler CA, Xie M, Zhang K, Lenton IC, Rubinsztein-Dunlop H, Brunner D, Bai B, Ozcan A, Midtvedt D, Wang H, Li T, Sladoje N, Lindblad J, Smith JT, Ochoa M, Barroso M, Intes X, Qiu T, Yu LY, You S, Liu Y, Ziatdinov MA, Kalinin SV, Sheridan A, Manor U, Nehme E, Goldenberg O, Shechtman Y, Moberg HK, Langhammer C, Špačková B, Helgadottir S, Midtvedt B, Argun A, Thalheim T, Cichos F, Bo S, Hubatsch L, Pineda J, Manzo C, Bachimanchi H, Selander E, Homs-Corbera A, Fränzl M, De Haan K, Rivenson Y, Korczak Z, Adiels CB, Mijalkov M, Veréb D, Chang YW, Pereira JB, Matuszewski D, Kylberg G, Sintorn IM, Caicedo JC, Cimini BA, Lediju Bell MA, Saraiva BM, Jacquemet G, Henriques R, Ouyang W, Le T, Gómez-De-Mariscal E, Sage D, Muñoz-Barrutia A, Lindqvist EJ, Bergman J. 2026. Roadmap on deep learning for microscopy. Journal of Physics: Photonics. 8(1), 012501.","chicago":"Volpe, Giovanni, Carolina Wählby, Lei Tian, Michael Hecht, Artur Yakimovich, Kristina Monakhova, Laura Waller, et al. “Roadmap on Deep Learning for Microscopy.” Journal of Physics: Photonics. IOP Publishing, 2026. https://doi.org/10.1088/2515-7647/ae0fd1.","ama":"Volpe G, Wählby C, Tian L, et al. Roadmap on deep learning for microscopy. Journal of Physics: Photonics. 2026;8(1). doi:10.1088/2515-7647/ae0fd1","apa":"Volpe, G., Wählby, C., Tian, L., Hecht, M., Yakimovich, A., Monakhova, K., … Bergman, J. (2026). Roadmap on deep learning for microscopy. Journal of Physics: Photonics. IOP Publishing. https://doi.org/10.1088/2515-7647/ae0fd1","mla":"Volpe, Giovanni, et al. “Roadmap on Deep Learning for Microscopy.” Journal of Physics: Photonics, vol. 8, no. 1, 012501, IOP Publishing, 2026, doi:10.1088/2515-7647/ae0fd1.","short":"G. Volpe, C. Wählby, L. Tian, M. Hecht, A. Yakimovich, K. Monakhova, L. Waller, I.F. Sbalzarini, C.A. Metzler, M. Xie, K. Zhang, I.C. Lenton, H. Rubinsztein-Dunlop, D. Brunner, B. Bai, A. Ozcan, D. Midtvedt, H. Wang, T. Li, N. Sladoje, J. Lindblad, J.T. Smith, M. Ochoa, M. Barroso, X. Intes, T. Qiu, L.Y. Yu, S. You, Y. Liu, M.A. Ziatdinov, S.V. Kalinin, A. Sheridan, U. Manor, E. Nehme, O. Goldenberg, Y. Shechtman, H.K. Moberg, C. Langhammer, B. Špačková, S. Helgadottir, B. Midtvedt, A. Argun, T. Thalheim, F. Cichos, S. Bo, L. Hubatsch, J. Pineda, C. Manzo, H. Bachimanchi, E. Selander, A. Homs-Corbera, M. Fränzl, K. De Haan, Y. Rivenson, Z. Korczak, C.B. Adiels, M. Mijalkov, D. Veréb, Y.W. Chang, J.B. Pereira, D. Matuszewski, G. Kylberg, I.M. Sintorn, J.C. Caicedo, B.A. Cimini, M.A. Lediju Bell, B.M. Saraiva, G. Jacquemet, R. Henriques, W. Ouyang, T. Le, E. Gómez-De-Mariscal, D. Sage, A. Muñoz-Barrutia, E.J. Lindqvist, J. Bergman, Journal of Physics: Photonics 8 (2026).","ieee":"G. Volpe et al., “Roadmap on deep learning for microscopy,” Journal of Physics: Photonics, vol. 8, no. 1. IOP Publishing, 2026."},"author":[{"first_name":"Giovanni","full_name":"Volpe, Giovanni","last_name":"Volpe"},{"first_name":"Carolina","full_name":"Wählby, Carolina","last_name":"Wählby"},{"last_name":"Tian","first_name":"Lei","full_name":"Tian, Lei"},{"first_name":"Michael","full_name":"Hecht, Michael","last_name":"Hecht"},{"last_name":"Yakimovich","full_name":"Yakimovich, Artur","first_name":"Artur"},{"last_name":"Monakhova","first_name":"Kristina","full_name":"Monakhova, Kristina"},{"last_name":"Waller","full_name":"Waller, Laura","first_name":"Laura"},{"last_name":"Sbalzarini","first_name":"Ivo F.","full_name":"Sbalzarini, Ivo F."},{"full_name":"Metzler, Christopher A.","first_name":"Christopher A.","last_name":"Metzler"},{"full_name":"Xie, Mingyang","first_name":"Mingyang","last_name":"Xie"},{"full_name":"Zhang, Kevin","first_name":"Kevin","last_name":"Zhang"},{"orcid":"0000-0002-5010-6984","last_name":"Lenton","first_name":"Isaac C","full_name":"Lenton, Isaac C","id":"a550210f-223c-11ec-8182-e2d45e817efb"},{"first_name":"Halina","full_name":"Rubinsztein-Dunlop, Halina","last_name":"Rubinsztein-Dunlop"},{"last_name":"Brunner","first_name":"Daniel","full_name":"Brunner, Daniel"},{"first_name":"Bijie","full_name":"Bai, Bijie","last_name":"Bai"},{"last_name":"Ozcan","first_name":"Aydogan","full_name":"Ozcan, Aydogan"},{"first_name":"Daniel","full_name":"Midtvedt, Daniel","last_name":"Midtvedt"},{"last_name":"Wang","full_name":"Wang, Hao","first_name":"Hao"},{"last_name":"Li","full_name":"Li, Tongyu","first_name":"Tongyu"},{"full_name":"Sladoje, Nataša","first_name":"Nataša","last_name":"Sladoje"},{"last_name":"Lindblad","first_name":"Joakim","full_name":"Lindblad, Joakim"},{"last_name":"Smith","full_name":"Smith, Jason T.","first_name":"Jason T."},{"first_name":"Marien","full_name":"Ochoa, Marien","last_name":"Ochoa"},{"last_name":"Barroso","first_name":"Margarida","full_name":"Barroso, Margarida"},{"full_name":"Intes, Xavier","first_name":"Xavier","last_name":"Intes"},{"first_name":"Tong","full_name":"Qiu, Tong","last_name":"Qiu"},{"full_name":"Yu, Li Yu","first_name":"Li Yu","last_name":"Yu"},{"last_name":"You","full_name":"You, Sixian","first_name":"Sixian"},{"first_name":"Yongtao","full_name":"Liu, Yongtao","last_name":"Liu"},{"first_name":"Maxim A.","full_name":"Ziatdinov, Maxim A.","last_name":"Ziatdinov"},{"first_name":"Sergei V.","full_name":"Kalinin, Sergei V.","last_name":"Kalinin"},{"full_name":"Sheridan, Arlo","first_name":"Arlo","last_name":"Sheridan"},{"last_name":"Manor","full_name":"Manor, Uri","first_name":"Uri"},{"last_name":"Nehme","first_name":"Elias","full_name":"Nehme, Elias"},{"first_name":"Ofri","full_name":"Goldenberg, Ofri","last_name":"Goldenberg"},{"last_name":"Shechtman","full_name":"Shechtman, Yoav","first_name":"Yoav"},{"first_name":"Henrik K.","full_name":"Moberg, Henrik K.","last_name":"Moberg"},{"full_name":"Langhammer, Christoph","first_name":"Christoph","last_name":"Langhammer"},{"last_name":"Špačková","first_name":"Barbora","full_name":"Špačková, Barbora"},{"last_name":"Helgadottir","full_name":"Helgadottir, Saga","first_name":"Saga"},{"full_name":"Midtvedt, Benjamin","first_name":"Benjamin","last_name":"Midtvedt"},{"last_name":"Argun","full_name":"Argun, Aykut","first_name":"Aykut"},{"last_name":"Thalheim","full_name":"Thalheim, Tobias","first_name":"Tobias"},{"full_name":"Cichos, Frank","first_name":"Frank","last_name":"Cichos"},{"first_name":"Stefano","full_name":"Bo, Stefano","last_name":"Bo"},{"last_name":"Hubatsch","first_name":"Lars","full_name":"Hubatsch, Lars"},{"full_name":"Pineda, Jesus","first_name":"Jesus","last_name":"Pineda"},{"last_name":"Manzo","first_name":"Carlo","full_name":"Manzo, Carlo"},{"full_name":"Bachimanchi, Harshith","first_name":"Harshith","last_name":"Bachimanchi"},{"last_name":"Selander","full_name":"Selander, Erik","first_name":"Erik"},{"first_name":"Antoni","full_name":"Homs-Corbera, Antoni","last_name":"Homs-Corbera"},{"first_name":"Martin","full_name":"Fränzl, Martin","last_name":"Fränzl"},{"last_name":"De Haan","first_name":"Kevin","full_name":"De Haan, Kevin"},{"first_name":"Yair","full_name":"Rivenson, Yair","last_name":"Rivenson"},{"last_name":"Korczak","full_name":"Korczak, Zofia","first_name":"Zofia"},{"first_name":"Caroline Beck","full_name":"Adiels, Caroline Beck","last_name":"Adiels"},{"full_name":"Mijalkov, Mite","first_name":"Mite","last_name":"Mijalkov"},{"first_name":"Dániel","full_name":"Veréb, Dániel","last_name":"Veréb"},{"last_name":"Chang","first_name":"Yu Wei","full_name":"Chang, Yu Wei"},{"full_name":"Pereira, Joana B.","first_name":"Joana B.","last_name":"Pereira"},{"full_name":"Matuszewski, Damian","first_name":"Damian","last_name":"Matuszewski"},{"last_name":"Kylberg","first_name":"Gustaf","full_name":"Kylberg, Gustaf"},{"full_name":"Sintorn, Ida Maria","first_name":"Ida Maria","last_name":"Sintorn"},{"first_name":"Juan C.","full_name":"Caicedo, Juan C.","last_name":"Caicedo"},{"last_name":"Cimini","full_name":"Cimini, Beth A.","first_name":"Beth A."},{"full_name":"Lediju Bell, Muyinatu A.","first_name":"Muyinatu A.","last_name":"Lediju Bell"},{"first_name":"Bruno M.","full_name":"Saraiva, Bruno M.","last_name":"Saraiva"},{"last_name":"Jacquemet","full_name":"Jacquemet, Guillaume","first_name":"Guillaume"},{"full_name":"Henriques, Ricardo","first_name":"Ricardo","last_name":"Henriques"},{"first_name":"Wei","full_name":"Ouyang, Wei","last_name":"Ouyang"},{"last_name":"Le","full_name":"Le, Trang","first_name":"Trang"},{"last_name":"Gómez-De-Mariscal","full_name":"Gómez-De-Mariscal, Estibaliz","first_name":"Estibaliz"},{"last_name":"Sage","first_name":"Daniel","full_name":"Sage, Daniel"},{"full_name":"Muñoz-Barrutia, Arrate","first_name":"Arrate","last_name":"Muñoz-Barrutia"},{"full_name":"Lindqvist, Ebba Josefson","first_name":"Ebba Josefson","last_name":"Lindqvist"},{"first_name":"Johanna","full_name":"Bergman, Johanna","last_name":"Bergman"}],"OA_place":"publisher","DOAJ_listed":"1","_id":"21370","date_created":"2026-03-01T23:01:39Z","oa_version":"Published Version","month":"03","ddc":["530"],"publication_identifier":{"eissn":["2515-7647"]},"external_id":{"arxiv":["2303.03793"]},"doi":"10.1088/2515-7647/ae0fd1","file_date_updated":"2026-03-02T09:05:53Z","type":"journal_article","language":[{"iso":"eng"}],"publisher":"IOP Publishing","date_published":"2026-03-01T00:00:00Z","status":"public","file":[{"file_size":16789781,"date_updated":"2026-03-02T09:05:53Z","relation":"main_file","checksum":"172720f1f0c5c9d06a282e52023a0030","date_created":"2026-03-02T09:05:53Z","file_name":"2026_JPhysPhotonics_Volpe.pdf","success":1,"content_type":"application/pdf","access_level":"open_access","file_id":"21375","creator":"dernst"}],"abstract":[{"text":"Through digital imaging, microscopy has evolved from primarily being a means for visual observation of life at the micro- and nano-scale, to a quantitative tool with ever-increasing resolution and throughput. Artificial intelligence, deep neural networks, and machine learning (ML) are all niche terms describing computational methods that have gained a pivotal role in microscopy-based research over the past decade. This Roadmap encompasses key aspects of how ML is applied to microscopy image data, with the aim of gaining scientific knowledge by improved image quality, automated detection, segmentation, classification and tracking of objects, and efficient merging of information from multiple imaging modalities. We aim to give the reader an overview of the key developments and an understanding of possibilities and limitations of ML for microscopy. It will be of interest to a wide cross-disciplinary audience in the physical sciences and life sciences.","lang":"eng"}],"publication_status":"published","intvolume":" 8","PlanS_conform":"1","article_processing_charge":"Yes","has_accepted_license":"1","title":"Roadmap on deep learning for microscopy","year":"2026","scopus_import":"1","publication":"Journal of Physics: Photonics","day":"01","article_number":"012501","department":[{"_id":"ScWa"}],"volume":8,"arxiv":1,"OA_type":"gold"},{"type":"journal_article","doi":"10.1126/science.adz8603","date_published":"2026-02-19T00:00:00Z","publisher":"AAAS","language":[{"iso":"eng"}],"month":"02","date_created":"2026-03-01T23:01:39Z","oa_version":"None","external_id":{"pmid":["41712710"]},"publication_identifier":{"eissn":["1095-9203"]},"project":[{"_id":"bd9b2118-d553-11ed-ba76-db24564edfea","name":"Young galaxies as tracers and agents of cosmic reionization","grant_number":"101076224"}],"author":[{"last_name":"Matthee","first_name":"Jorryt J","full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","id":"7439a258-f3c0-11ec-9501-9df22fe06720"}],"pmid":1,"acknowledgement":"The author acknowledges the support from the European Union (European Research Council, AGENTS, 101076224).","citation":{"ieee":"J. J. Matthee, “Black holes disguised as little red dots,” Science, vol. 391, no. 6787. AAAS, pp. 767–768, 2026.","short":"J.J. Matthee, Science 391 (2026) 767–768.","mla":"Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” Science, vol. 391, no. 6787, AAAS, 2026, pp. 767–68, doi:10.1126/science.adz8603.","apa":"Matthee, J. J. (2026). Black holes disguised as little red dots. Science. AAAS. https://doi.org/10.1126/science.adz8603","chicago":"Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” Science. AAAS, 2026. https://doi.org/10.1126/science.adz8603.","ama":"Matthee JJ. Black holes disguised as little red dots. Science. 2026;391(6787):767-768. doi:10.1126/science.adz8603","ista":"Matthee JJ. 2026. Black holes disguised as little red dots. Science. 391(6787), 767–768."},"issue":"6787","_id":"21371","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","corr_author":"1","date_updated":"2026-03-02T09:15:45Z","article_type":"comment","volume":391,"department":[{"_id":"JoMa"}],"OA_type":"closed access","scopus_import":"1","year":"2026","title":"Black holes disguised as little red dots","day":"19","publication":"Science","article_processing_charge":"No","page":"767-768","abstract":[{"text":"There may be a newly identified early phase of supermassive black hole growth","lang":"eng"}],"publication_status":"published","status":"public","intvolume":" 391"},{"article_processing_charge":"No","PlanS_conform":"1","intvolume":" 8","file":[{"date_created":"2026-03-02T09:24:44Z","file_name":"2026_JPhysPhotonics_Volpe.pdf","content_type":"application/pdf","success":1,"relation":"main_file","date_updated":"2026-03-02T09:24:44Z","file_size":16789781,"checksum":"172720f1f0c5c9d06a282e52023a0030","file_id":"21376","creator":"dernst","access_level":"open_access"}],"abstract":[{"lang":"eng","text":"Cold atom experiments show that a mobile impurity particle immersed in a weakly interacting Bose-Einstein condensate forms a well-defined quasiparticle (Bose polaron) for weak to moderate impurity-boson interaction strengths, whereas a significant line broadening is consistently observed for strong interactions. Motivated by this, we introduce a phenomenological theory based on the assumption that the most relevant states are characterized by the impurity correlated with at most one boson, since they have the largest overlap with the uncorrelated states to which the most common experimental probes couple. These experimentally relevant states can, however, decay to lower energy states characterized by correlations involving multiple bosons, and we model this using a minimal variational wave function combined with a complex impurity-boson interaction strength. We first motivate this approach by comparing to a more elaborate theory that includes correlations with up to two bosons. Our phenomenological model is shown to recover the main results of two recent experiments probing both the spectral and the nonequilibrium properties of the Bose polaron. Our work offers an intuitive framework for analyzing experimental data and highlights the importance of understanding the complicated problem of the Bose polaron decay in a many-body setting."}],"publication_status":"published","status":"public","ec_funded":1,"OA_type":"gold","arxiv":1,"volume":8,"article_number":"L012034","department":[{"_id":"MiLe"}],"day":"06","publication":"Physical Review Research","year":"2026","scopus_import":"1","has_accepted_license":"1","title":"Phenomenological model of decaying Bose polarons","_id":"21373","DOAJ_listed":"1","OA_place":"publisher","author":[{"id":"d1c405be-ae15-11ed-8510-ccf53278162e","full_name":"Al Hyder, Ragheed","first_name":"Ragheed","last_name":"Al Hyder"},{"full_name":"Bruun, G. M.","first_name":"G. M.","last_name":"Bruun"},{"full_name":"Pohl, T.","first_name":"T.","last_name":"Pohl"},{"id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","full_name":"Lemeshko, Mikhail","first_name":"Mikhail","last_name":"Lemeshko","orcid":"0000-0002-6990-7802"},{"id":"37D278BC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0393-5525","first_name":"Artem","full_name":"Volosniev, Artem","last_name":"Volosniev"}],"citation":{"mla":"Al Hyder, Ragheed, et al. “Phenomenological Model of Decaying Bose Polarons.” Physical Review Research, vol. 8, L012034, American Physical Society, 2026, doi:10.1103/16dk-5dgx.","apa":"Al Hyder, R., Bruun, G. M., Pohl, T., Lemeshko, M., & Volosniev, A. (2026). Phenomenological model of decaying Bose polarons. Physical Review Research. American Physical Society. https://doi.org/10.1103/16dk-5dgx","ama":"Al Hyder R, Bruun GM, Pohl T, Lemeshko M, Volosniev A. Phenomenological model of decaying Bose polarons. Physical Review Research. 2026;8. doi:10.1103/16dk-5dgx","chicago":"Al Hyder, Ragheed, G. M. Bruun, T. Pohl, Mikhail Lemeshko, and Artem Volosniev. “Phenomenological Model of Decaying Bose Polarons.” Physical Review Research. American Physical Society, 2026. https://doi.org/10.1103/16dk-5dgx.","ista":"Al Hyder R, Bruun GM, Pohl T, Lemeshko M, Volosniev A. 2026. Phenomenological model of decaying Bose polarons. Physical Review Research. 8, L012034.","ieee":"R. Al Hyder, G. M. Bruun, T. Pohl, M. Lemeshko, and A. Volosniev, “Phenomenological model of decaying Bose polarons,” Physical Review Research, vol. 8. American Physical Society, 2026.","short":"R. Al Hyder, G.M. Bruun, T. Pohl, M. Lemeshko, A. Volosniev, Physical Review Research 8 (2026)."},"acknowledgement":"We thank Georgios Koutentakis, Frédéric Chevy, Hussam Al Daas, and Richard Schmidt for fruitful discussions; Jan Arlt for sharing their experimental data and many fruitful discussions; and Christoph Eigen for sharing their experimental data and inspiring discussions. R.A., T.P., and G.M.B. have been supported in part by the Danish National Research Foundation through the Center of Excellence “CCQ” (Grant Agreement No. DNRF156) and the Independent Research Fund Denmark–Natural Sciences via Grant No. DFF-8021-00233B. R.A., A.G.V., and M.L. acknowledge support by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). R.A. received funding from the Austrian Academy of Science ÖAW Grant No. PR1029OEAW03.","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_type":"letter_note","date_updated":"2026-03-02T09:27:26Z","oa":1,"quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","corr_author":"1","date_published":"2026-02-06T00:00:00Z","publisher":"American Physical Society","language":[{"iso":"eng"}],"type":"journal_article","doi":"10.1103/16dk-5dgx","file_date_updated":"2026-03-02T09:24:44Z","external_id":{"arxiv":["2507.04143"]},"publication_identifier":{"issn":["2643-1564"]},"ddc":["530"],"project":[{"call_identifier":"H2020","grant_number":"801770","name":"Angulon: physics and applications of a new quasiparticle","_id":"2688CF98-B435-11E9-9278-68D0E5697425"},{"_id":"8fa7db46-16d5-11f0-9cad-917600954daf","name":"Polarons in Lead Halide Perovskites","grant_number":"12078"}],"month":"02","oa_version":"Published Version","date_created":"2026-03-01T23:01:39Z"},{"date_updated":"2026-03-02T08:49:20Z","oa":1,"quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21374","OA_place":"repository","author":[{"full_name":"Antić, Todor","first_name":"Todor","last_name":"Antić"},{"first_name":"Aleksa","full_name":"Džuklevski, Aleksa","last_name":"Džuklevski"},{"first_name":"Jiří","full_name":"Fiala, Jiří","last_name":"Fiala"},{"last_name":"Kratochvíl","first_name":"Jan","full_name":"Kratochvíl, Jan"},{"first_name":"Giuseppe","full_name":"Liotta, Giuseppe","last_name":"Liotta"},{"id":"f86f7148-b140-11ec-9577-95435b8df824","first_name":"Morteza","full_name":"Saghafian, Morteza","last_name":"Saghafian"},{"last_name":"Saumell","first_name":"Maria","full_name":"Saumell, Maria"},{"last_name":"Zink","full_name":"Zink, Johannes","first_name":"Johannes"}],"citation":{"chicago":"Antić, Todor, Aleksa Džuklevski, Jiří Fiala, Jan Kratochvíl, Giuseppe Liotta, Morteza Saghafian, Maria Saumell, and Johannes Zink. “Edge-Constrained Hamiltonian Paths on a Point Set.” In 51st International Conference on Current Trends in Theory and Practice of Computer Science, 16448:532–46. Springer Nature, 2026. https://doi.org/10.1007/978-3-032-17801-5_39.","ama":"Antić T, Džuklevski A, Fiala J, et al. Edge-constrained Hamiltonian paths on a point set. In: 51st International Conference on Current Trends in Theory and Practice of Computer Science. Vol 16448. Springer Nature; 2026:532-546. doi:10.1007/978-3-032-17801-5_39","ista":"Antić T, Džuklevski A, Fiala J, Kratochvíl J, Liotta G, Saghafian M, Saumell M, Zink J. 2026. Edge-constrained Hamiltonian paths on a point set. 51st International Conference on Current Trends in Theory and Practice of Computer Science. SOFSEM: Conference on Current Trends in Theory and Practice of Computer Science, LNCS, vol. 16448, 532–546.","apa":"Antić, T., Džuklevski, A., Fiala, J., Kratochvíl, J., Liotta, G., Saghafian, M., … Zink, J. (2026). Edge-constrained Hamiltonian paths on a point set. In 51st International Conference on Current Trends in Theory and Practice of Computer Science (Vol. 16448, pp. 532–546). Krakow, Poland: Springer Nature. https://doi.org/10.1007/978-3-032-17801-5_39","mla":"Antić, Todor, et al. “Edge-Constrained Hamiltonian Paths on a Point Set.” 51st International Conference on Current Trends in Theory and Practice of Computer Science, vol. 16448, Springer Nature, 2026, pp. 532–46, doi:10.1007/978-3-032-17801-5_39.","short":"T. Antić, A. Džuklevski, J. Fiala, J. Kratochvíl, G. Liotta, M. Saghafian, M. Saumell, J. Zink, in:, 51st International Conference on Current Trends in Theory and Practice of Computer Science, Springer Nature, 2026, pp. 532–546.","ieee":"T. Antić et al., “Edge-constrained Hamiltonian paths on a point set,” in 51st International Conference on Current Trends in Theory and Practice of Computer Science, Krakow, Poland, 2026, vol. 16448, pp. 532–546."},"acknowledgement":"We thank the organizers of the HOMONOLO 2024 workshop in Nová Louka, Czech Republic, for the fruitful atmosphere where the research on this project was initiated.\r\n\r\nT. Antić, A. Džuklevski, J. Kratochvíl and M. Saumell received funding from GAČR grant 23–04949X, T.A and A.Dž were additionally supported by GAUK grant SVV–2025–260822. G. Liotta was supported in part by MUR of Italy, PRIN Project no. 2022TS4Y3N – EXPAND and PON Project ARS01_00540. J. Fiala was in part supported by GAČR grant 25-16847S.","external_id":{"arxiv":["2511.22526"]},"publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783032178008"]},"month":"02","oa_version":"Preprint","date_created":"2026-03-01T23:01:40Z","publisher":"Springer Nature","date_published":"2026-02-13T00:00:00Z","language":[{"iso":"eng"}],"type":"conference","doi":"10.1007/978-3-032-17801-5_39","conference":{"end_date":"2026-02-13","location":"Krakow, Poland","name":"SOFSEM: Conference on Current Trends in Theory and Practice of Computer Science","start_date":"2026-02-09"},"intvolume":" 16448","abstract":[{"lang":"eng","text":"Let . S be a set of distinct points in general position in the\r\nEuclidean plane. A plane Hamiltonian path on . S is a crossing-free geometric path such that every point of .S is a vertex of the path. It is\r\nknown that, if. S is sufficiently large, there exist three edge-disjoint plane\r\nHamiltonian paths on . S. In this paper we study an edge-constrained\r\nversion of the problem of finding Hamiltonian paths on a point set. We\r\nfirst consider the problem of finding a single plane Hamiltonian path . π\r\nwith endpoints .s, t ∈ S and constraints given by a segment . ab, where\r\n.a, b ∈ S. We consider the following scenarios: (i) .ab ∈ π; (ii) .ab π. We\r\ncharacterize those quintuples . S, a, b, s, t for which . π exists. Secondly,\r\nwe consider the problem of finding two plane Hamiltonian paths . π1, π2\r\non a set . S with constraints given by a segment . ab, where .a, b ∈ S. We\r\nconsider the following scenarios: (i) .π1 and .π2 share no edges and .ab is\r\nan edge of . π1; (ii) .π1 and .π2 share no edges and none of them includes\r\n.ab as an edge; (iii) both .π1 and .π2 include .ab as an edge and share no\r\nother edges. In all cases, we characterize those triples . S, a, b for which\r\n.π1 and .π2 exist."}],"publication_status":"published","status":"public","page":"532-546","article_processing_charge":"No","day":"13","publication":"51st International Conference on Current Trends in Theory and Practice of Computer Science","scopus_import":"1","year":"2026","title":"Edge-constrained Hamiltonian paths on a point set","alternative_title":["LNCS"],"arxiv":1,"OA_type":"green","department":[{"_id":"HeEd"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2511.22526"}],"volume":16448},{"publication_status":"published","file":[{"content_type":"application/pdf","success":1,"date_created":"2026-03-02T15:21:27Z","file_name":"2026_NatureMetab_AmrapaliVishwanath.pdf","checksum":"365932a599d05bc9ce8a57204e7a1465","file_size":5326608,"date_updated":"2026-03-02T15:21:27Z","relation":"main_file","creator":"dernst","file_id":"21392","access_level":"open_access"}],"abstract":[{"text":"From insects to mammals, essential brain functions, such as forming long-term memories (LTMs), increase metabolic activity in stimulated neurons to meet the energetic demand associated with brain activation. However, while impairing neuronal metabolism limits brain performance, whether expanding the metabolic capacity of neurons boosts brain function remains poorly understood. Here, we show that LTM formation of flies and mice can be enhanced by increasing mitochondrial metabolism in central memory circuits. By knocking down the mitochondrial Ca2+ exporter Letm1, we favour Ca2+ retention in the mitochondrial matrix of neurons due to reduction of mitochondrial H+/Ca2+ exchange. The resulting increase in mitochondrial Ca2+ over-activates mitochondrial metabolism in neurons of central memory circuits, leading to improved LTM storage in training paradigms in which wild-type counterparts of both species fail to remember. Our findings unveil an evolutionarily conserved mechanism that controls mitochondrial metabolism in neurons and indicate its involvement in shaping higher brain functions, such as LTM.","lang":"eng"}],"status":"public","PlanS_conform":"1","intvolume":" 8","article_processing_charge":"Yes (in subscription journal)","page":"467-488","scopus_import":"1","year":"2026","title":"Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species","has_accepted_license":"1","day":"11","publication":"Nature Metabolism","volume":8,"department":[{"_id":"TiVo"}],"OA_type":"hybrid","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_type":"original","date_updated":"2026-03-02T15:23:10Z","pmid":1,"author":[{"first_name":"Anjali","full_name":"Amrapali Vishwanath, Anjali","last_name":"Amrapali Vishwanath"},{"last_name":"Comyn","first_name":"Typhaine","full_name":"Comyn, Typhaine"},{"full_name":"Mira, Rodrigo G.","first_name":"Rodrigo G.","last_name":"Mira"},{"full_name":"Brossier, Claire","first_name":"Claire","last_name":"Brossier"},{"full_name":"Pascual-Caro, Carlos","first_name":"Carlos","last_name":"Pascual-Caro"},{"first_name":"Maya","full_name":"Faour, Maya","last_name":"Faour"},{"full_name":"Boumendil, Kahina","first_name":"Kahina","last_name":"Boumendil"},{"id":"BA06AFEE-A4BA-11EA-AE5C-14673DDC885E","orcid":"0000-0003-4252-1608","last_name":"Chintaluri","first_name":"Chaitanya","full_name":"Chintaluri, Chaitanya"},{"last_name":"Ramon-Duaso","first_name":"Carla","full_name":"Ramon-Duaso, Carla"},{"first_name":"Ruolin","full_name":"Fan, Ruolin","last_name":"Fan"},{"full_name":"Ghosh, Kishalay","first_name":"Kishalay","last_name":"Ghosh"},{"first_name":"Helen","full_name":"Farrants, Helen","last_name":"Farrants"},{"last_name":"Berwick","full_name":"Berwick, Jean-Paul","first_name":"Jean-Paul"},{"last_name":"Sivakumar","full_name":"Sivakumar, Riya","first_name":"Riya"},{"last_name":"Lopez-Manzaneda","first_name":"Mario","full_name":"Lopez-Manzaneda, Mario"},{"first_name":"Eric R.","full_name":"Schreiter, Eric R.","last_name":"Schreiter"},{"last_name":"Preat","first_name":"Thomas","full_name":"Preat, Thomas"},{"id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","orcid":"0000-0003-3295-6181","last_name":"Vogels","first_name":"Tim P","full_name":"Vogels, Tim P"},{"last_name":"Rangaraju","first_name":"Vidhya","full_name":"Rangaraju, Vidhya"},{"last_name":"Busquets-Garcia","full_name":"Busquets-Garcia, Arnau","first_name":"Arnau"},{"last_name":"Plaçais","full_name":"Plaçais, Pierre-Yves","first_name":"Pierre-Yves"},{"first_name":"Alice","full_name":"Pavlowsky, Alice","last_name":"Pavlowsky"},{"last_name":"de Juan-Sanz","first_name":"Jaime","full_name":"de Juan-Sanz, Jaime"}],"acknowledgement":"We thank all members of the laboratory of J.d.J.-S. for insightful discussions and comments. We thank S. Perez for technical assistance. This work was made possible by the Paris Brain Institute Diane Barriere Chair in Synaptic Bioenergetics awarded to J.d.J.-S., who is also supported by an ERC Starting Grant (SynaptoEnergy, European Research Council; ERC-StG-852873), 2019 ATIP-Avenir Grant (CNRS, Inserm), a Big Brain Theory Grant (ICM Foundation) and a Kavli Exploratory Award (Kavli Foundation). This work was also supported by an ERC Advanced Grant (EnergyMeMo; ERC-AdG-741550) to T.P. and grants from the Agence Nationale de la Recherche to P.Y.P. (ANR-20-CE92-0047-01), T.P. (ANR-23-CE16-0029-01), A.P. and J.d.J.-S. (ANR-22-CE16-0020) and J.d.J.-S. (ANR-24-CE16-0221). T.P., P.Y.P. and J.d.J.-S. are permanent CNRS researchers. A.P. is a permanent ESPCI associate professor. T.C. was funded by the French Ministry of Research and the Fondation pour la Recherche Médicale. V.R. was funded by the Max Planck Society, the Chan Zuckerberg Initiative DAF, an advised fund of the Silicon Valley Community Foundation grant number 2024-349543 and the NIH Director’s New Innovator Award (DP2 MH140148). A.B.-G. and C.R.-D. received funding from an ERC Starting Grant (HighMemory; ERC-StG-948217), the Ministry of Economy and Competitiveness (PID2021-122795OB-I00) and the Departament d’Economia i Coneixement de la Generalitat de Catalunya (SGR 00022). T.P.V. was funded by the Wellcome Trust and a Royal Society Sir Henry Dale Research Fellowship (WT100000) and a Wellcome Trust Senior Research Fellowship (214316/Z/18/Z). K.G. was supported by the DIM C-BRAINS, funded by the Conseil Régional d’Ile-de-France. The contributions of H.F. and E.R.S. were supported by the Howard Hughes Medical Institute. The PHENO-ICMice animal Core at ICM is supported by two ‘Investissements d’avenir’ (ANR-10- IAIHU-06 and ANR-11-INBS-0011-NeurATRIS) and the Fondation pour la Recherche Médicale.","citation":{"short":"A. Amrapali Vishwanath, T. Comyn, R.G. Mira, C. Brossier, C. Pascual-Caro, M. Faour, K. Boumendil, C. Chintaluri, C. Ramon-Duaso, R. Fan, K. Ghosh, H. Farrants, J.-P. Berwick, R. Sivakumar, M. Lopez-Manzaneda, E.R. Schreiter, T. Preat, T.P. Vogels, V. Rangaraju, A. Busquets-Garcia, P.-Y. Plaçais, A. Pavlowsky, J. de Juan-Sanz, Nature Metabolism 8 (2026) 467–488.","ieee":"A. Amrapali Vishwanath et al., “Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species,” Nature Metabolism, vol. 8, no. 2. Springer Nature, pp. 467–488, 2026.","ista":"Amrapali Vishwanath A, Comyn T, Mira RG, Brossier C, Pascual-Caro C, Faour M, Boumendil K, Chintaluri C, Ramon-Duaso C, Fan R, Ghosh K, Farrants H, Berwick J-P, Sivakumar R, Lopez-Manzaneda M, Schreiter ER, Preat T, Vogels TP, Rangaraju V, Busquets-Garcia A, Plaçais P-Y, Pavlowsky A, de Juan-Sanz J. 2026. Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species. Nature Metabolism. 8(2), 467–488.","chicago":"Amrapali Vishwanath, Anjali, Typhaine Comyn, Rodrigo G. Mira, Claire Brossier, Carlos Pascual-Caro, Maya Faour, Kahina Boumendil, et al. “Mitochondrial Ca2+ Efflux Controls Neuronal Metabolism and Long-Term Memory across Species.” Nature Metabolism. Springer Nature, 2026. https://doi.org/10.1038/s42255-026-01451-w.","ama":"Amrapali Vishwanath A, Comyn T, Mira RG, et al. Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species. Nature Metabolism. 2026;8(2):467-488. doi:10.1038/s42255-026-01451-w","mla":"Amrapali Vishwanath, Anjali, et al. “Mitochondrial Ca2+ Efflux Controls Neuronal Metabolism and Long-Term Memory across Species.” Nature Metabolism, vol. 8, no. 2, Springer Nature, 2026, pp. 467–88, doi:10.1038/s42255-026-01451-w.","apa":"Amrapali Vishwanath, A., Comyn, T., Mira, R. G., Brossier, C., Pascual-Caro, C., Faour, M., … de Juan-Sanz, J. (2026). Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species. Nature Metabolism. Springer Nature. https://doi.org/10.1038/s42255-026-01451-w"},"issue":"2","_id":"21378","OA_place":"publisher","month":"02","oa_version":"Published Version","date_created":"2026-03-02T10:04:49Z","external_id":{"pmid":["41673453"]},"project":[{"_id":"c084a126-5a5b-11eb-8a69-d75314a70a87","name":"What’s in a memory? Spatiotemporal dynamics in strongly coupled recurrent neuronal networks.","grant_number":"214316/Z/18/Z"}],"publication_identifier":{"eissn":["2522-5812"]},"ddc":["570"],"doi":"10.1038/s42255-026-01451-w","file_date_updated":"2026-03-02T15:21:27Z","type":"journal_article","date_published":"2026-02-11T00:00:00Z","publisher":"Springer Nature","language":[{"iso":"eng"}]},{"year":"2026","scopus_import":"1","has_accepted_license":"1","title":"On minimizing curves in a Brownian potential","day":"14","publication":"Probability Theory and Related Fields","department":[{"_id":"JuFi"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1007/s00440-026-01468-y"}],"OA_type":"hybrid","publication_status":"epub_ahead","abstract":[{"lang":"eng","text":"We study a (1 + 1)-dimensional semi-discrete random variational problem that can be interpreted as the geometrically linearized version of the critical 2-dimensional random field Ising model. The scaling of the correlation length of the latter was recently characterized in Probab. Duke Math. J. 172(9), 1781–1811 (2023) and arXiv:2011.08768v3, (2022); our analysis is reminiscent of the multi-scale approach of the latter work and of Combinatorica 9, 161–187 (1989) . We show that at every dyadic scale from the system size down to the lattice spacing the minimizer contains at most order-one Dirichlet energy per unit length. We also establish a quenched homogenization result in the sense that the leading order of the minimal energy becomes deterministic as the ratio system size / lattice spacing diverges. To this purpose we adapt arguments from arXiv:2401.06768, (2024) on the (d + 1)-dimensional version our the model, with a Brownian replacing the white noise potential, to obtain the initial large-scale bounds. Based on our estimate of the (p = 3)-Dirichlet energy, we give an informal justification of the geometric linearization. Our bounds, which are oblivious to the microscopic cut-off scale provided by the lattice spacing, yield tightness of the law of minimizers in the space of continuous functions as the lattice spacing is sent to zero."}],"status":"public","article_processing_charge":"Yes (via OA deal)","month":"02","oa_version":"Published Version","date_created":"2026-03-02T10:05:23Z","publication_identifier":{"eissn":["1432-2064"],"issn":["0178-8051"]},"ddc":["510"],"doi":"10.1007/s00440-026-01468-y","type":"journal_article","publisher":"Springer Nature","date_published":"2026-02-14T00:00:00Z","language":[{"iso":"eng"}],"corr_author":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_updated":"2026-03-02T15:15:13Z","article_type":"original","author":[{"last_name":"Otto","full_name":"Otto, Felix","first_name":"Felix"},{"first_name":"Matteo","full_name":"Palmieri, Matteo","last_name":"Palmieri"},{"id":"bf0c729b-2619-11f0-8024-9d69bb2b8b20","first_name":"Christian","full_name":"Wagner, Christian","last_name":"Wagner"}],"citation":{"ista":"Otto F, Palmieri M, Wagner C. 2026. On minimizing curves in a Brownian potential. Probability Theory and Related Fields.","chicago":"Otto, Felix, Matteo Palmieri, and Christian Wagner. “On Minimizing Curves in a Brownian Potential.” Probability Theory and Related Fields. Springer Nature, 2026. https://doi.org/10.1007/s00440-026-01468-y.","ama":"Otto F, Palmieri M, Wagner C. On minimizing curves in a Brownian potential. Probability Theory and Related Fields. 2026. doi:10.1007/s00440-026-01468-y","mla":"Otto, Felix, et al. “On Minimizing Curves in a Brownian Potential.” Probability Theory and Related Fields, Springer Nature, 2026, doi:10.1007/s00440-026-01468-y.","apa":"Otto, F., Palmieri, M., & Wagner, C. (2026). On minimizing curves in a Brownian potential. Probability Theory and Related Fields. Springer Nature. https://doi.org/10.1007/s00440-026-01468-y","short":"F. Otto, M. Palmieri, C. Wagner, Probability Theory and Related Fields (2026).","ieee":"F. Otto, M. Palmieri, and C. Wagner, “On minimizing curves in a Brownian potential,” Probability Theory and Related Fields. Springer Nature, 2026."},"acknowledgement":"FO and CW thank Ron Peled for insightful discussions on the white-noise multi-dimensional case in the Fall of 2023. CW thanks Barbara Dembin for the discussion during a workshop in Spring 2025. The work was done while the authors were affiliated with the Max Planck Institute for Mathematics in the Sciences; CW thanks the MPI for the support and warm hospitality. Open access funding provided by Institute of Science and Technology (IST Austria).","_id":"21379","OA_place":"publisher"},{"date_created":"2026-03-02T10:06:10Z","oa_version":"Published Version","month":"02","ddc":["520"],"publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"external_id":{"arxiv":["2512.08484"]},"type":"journal_article","file_date_updated":"2026-03-02T14:51:57Z","doi":"10.1051/0004-6361/202557358","language":[{"iso":"eng"}],"publisher":"EDP Sciences","date_published":"2026-02-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_type":"original","date_updated":"2026-03-02T15:10:27Z","oa":1,"citation":{"ista":"Giménez-Alcázar A, Amorín R, Vílchez JM, Hernán-Caballero A, González-Otero M, Arroyo-Polonio A, Iglesias-Páramo J, Lumbreras-Calle A, Fernández-Ontiveros JA, López-Sanjuan C, Bonatto L, González Delgado RM, Kehrig C, Torralba Torregrosa A, Rahna PT, Jiménez-Teja Y, Márquez I, Breda I, Álvarez-Candal A, Abramo R, Alcaniz J, Benitez N, Bonoli S, Carneiro S, Cenarro J, Cristóbal-Hornillos D, Dupke R, Ederoclite A, Hernández-Monteagudo C, Marín-Franch A, Mendes de Oliveira C, Moles M, Sodré L, Taylor K, Varela J, Vázquez Ramió H. 2026. J-PAS: First identification, physical properties, and ionization efficiency of extreme emission line galaxies. Astronomy & Astrophysics. 706, A261.","chicago":"Giménez-Alcázar, A., R. Amorín, J. M. Vílchez, A. Hernán-Caballero, M. González-Otero, A. Arroyo-Polonio, J. Iglesias-Páramo, et al. “J-PAS: First Identification, Physical Properties, and Ionization Efficiency of Extreme Emission Line Galaxies.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202557358.","ama":"Giménez-Alcázar A, Amorín R, Vílchez JM, et al. J-PAS: First identification, physical properties, and ionization efficiency of extreme emission line galaxies. Astronomy & Astrophysics. 2026;706. doi:10.1051/0004-6361/202557358","mla":"Giménez-Alcázar, A., et al. “J-PAS: First Identification, Physical Properties, and Ionization Efficiency of Extreme Emission Line Galaxies.” Astronomy & Astrophysics, vol. 706, A261, EDP Sciences, 2026, doi:10.1051/0004-6361/202557358.","apa":"Giménez-Alcázar, A., Amorín, R., Vílchez, J. M., Hernán-Caballero, A., González-Otero, M., Arroyo-Polonio, A., … Vázquez Ramió, H. (2026). J-PAS: First identification, physical properties, and ionization efficiency of extreme emission line galaxies. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202557358","short":"A. Giménez-Alcázar, R. Amorín, J.M. Vílchez, A. Hernán-Caballero, M. González-Otero, A. Arroyo-Polonio, J. Iglesias-Páramo, A. Lumbreras-Calle, J.A. Fernández-Ontiveros, C. López-Sanjuan, L. Bonatto, R.M. González Delgado, C. Kehrig, A. Torralba Torregrosa, P.T. Rahna, Y. Jiménez-Teja, I. Márquez, I. Breda, A. Álvarez-Candal, R. Abramo, J. Alcaniz, N. Benitez, S. Bonoli, S. Carneiro, J. Cenarro, D. Cristóbal-Hornillos, R. Dupke, A. Ederoclite, C. Hernández-Monteagudo, A. Marín-Franch, C. Mendes de Oliveira, M. Moles, L. Sodré, K. Taylor, J. Varela, H. Vázquez Ramió, Astronomy & Astrophysics 706 (2026).","ieee":"A. Giménez-Alcázar et al., “J-PAS: First identification, physical properties, and ionization efficiency of extreme emission line galaxies,” Astronomy & Astrophysics, vol. 706. EDP Sciences, 2026."},"acknowledgement":"We thank the referee for several helpful suggestions. AGA, MGO and IM acknowledge financial support from the Severo Ochoa grant CEX2021-001131-S, funded by MICIU/AEI/10.13039/501100011033. AGA also acknowledges FPI support under grant code CEX2021-001131-S20-7. Both AGA and MGO acknowledge support from the research grant\r\nPID2022-136598NB-C32 (“Estallidos8”). MGO also acknowledges the support by the project ref. AST22_00001_Subp_11 funded from the EU – NextGenerationEU. RA acknowledges support from PID2023-147386NB-I00 funded by MICIU/AEI/10.13039/501100011033 and ERDF/EU. IM acknowledges support from PID2022-140871NB-C21 funded by MICIU/AEI/10.13039/501100011033 and FEDER/UE. RGD acknowledge financial support from the project PID2022-141755NB-I00, and the Severo Ochoa grant CEX2021-001131-S funded\r\nby MICIU/AEI/ 10.13039/501100011033. JAFO and AE acknowledge support from the Spanish Ministry of Science and Innovation and the EU–NextGenerationEU through the RRF project ICTS-MRR-2021-03-CEFCA. AHC and ALC acknowledge support from MCIN/AEI/10.13039/501100011033, “ERDF A way of making Europe”, and “EU NextGenerationEU/PRTR” through PID2021-124918NB-C44 and CNS2023-145339, as well as from the RRF project ICTS-MRR-2021-03-CEFCA ALC and RPT acknowledge the financial\r\nsupport from the European Union – NextGenerationEU through the RRF program Planes Complementarios con las CCAA de Astrofísica y Física de Altas Energías – LA4. I.B. acknowledges support from the EU Horizon 2020 programme (Marie Sklodowska-Curie Grant 101059532) and the Franziska Seidl Funding Program, University of Vienna. This paper has gone through internal‘ review by the J-PAS collaboration. Based on observations made with the\r\nJST/T250 telescope and JPCam at the Observatorio Astrofísico de Javalambre (OAJ), in Teruel, owned, managed, and operated by the Centro de Estudios de Física del Cosmos de Aragón (CEFCA). We acknowledge the OAJ Data Processing and Archiving Unit (UPAD) for reducing and calibrating the OAJ data used in this work. Funding for the J-PAS Project has been provided by the Governments of Spain and Aragón through the Fondo de Inversiones de Teruel; the Aragonese Government through the Research Groups E96, E103, E16_17R, E16_20R, and E16_23R; the Spanish Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033 y FEDER, Una manera de hacer Europa) with grants PID2021-124918NB-C41, PID2021-124918NB-C42, PID2021-124918NA-C43, and PID2021-124918NB-C44; the Spanish Ministry\r\nof Science, Innovation and Universities (MCIU/AEI/FEDER, UE) with grants\r\nPGC2018-097585-B-C21 and PGC2018-097585-B-C22; the Spanish Ministry of Economy and Competitiveness (MINECO) under AYA2015-66211-C2-1-P, AYA2015-66211-C2-2, and AYA2012-30789; and European FEDER funding (FCDD10-4E-867, FCDD13-4E-2685).","author":[{"last_name":"Giménez-Alcázar","full_name":"Giménez-Alcázar, A.","first_name":"A."},{"first_name":"R.","full_name":"Amorín, R.","last_name":"Amorín"},{"last_name":"Vílchez","full_name":"Vílchez, J. M.","first_name":"J. M."},{"last_name":"Hernán-Caballero","first_name":"A.","full_name":"Hernán-Caballero, A."},{"first_name":"M.","full_name":"González-Otero, M.","last_name":"González-Otero"},{"last_name":"Arroyo-Polonio","full_name":"Arroyo-Polonio, A.","first_name":"A."},{"last_name":"Iglesias-Páramo","first_name":"J.","full_name":"Iglesias-Páramo, J."},{"first_name":"A.","full_name":"Lumbreras-Calle, A.","last_name":"Lumbreras-Calle"},{"last_name":"Fernández-Ontiveros","first_name":"J. A.","full_name":"Fernández-Ontiveros, J. A."},{"last_name":"López-Sanjuan","first_name":"C.","full_name":"López-Sanjuan, C."},{"full_name":"Bonatto, L.","first_name":"L.","last_name":"Bonatto"},{"last_name":"González Delgado","full_name":"González Delgado, R. M.","first_name":"R. M."},{"first_name":"C.","full_name":"Kehrig, C.","last_name":"Kehrig"},{"orcid":"0000-0001-5586-6950","first_name":"Alberto","full_name":"Torralba Torregrosa, Alberto","last_name":"Torralba Torregrosa","id":"018f0249-0e87-11f0-b167-cbce08fbd541"},{"last_name":"Rahna","first_name":"P. T.","full_name":"Rahna, P. T."},{"full_name":"Jiménez-Teja, Y.","first_name":"Y.","last_name":"Jiménez-Teja"},{"full_name":"Márquez, I.","first_name":"I.","last_name":"Márquez"},{"first_name":"I.","full_name":"Breda, I.","last_name":"Breda"},{"last_name":"Álvarez-Candal","full_name":"Álvarez-Candal, A.","first_name":"A."},{"last_name":"Abramo","first_name":"R.","full_name":"Abramo, R."},{"full_name":"Alcaniz, J.","first_name":"J.","last_name":"Alcaniz"},{"last_name":"Benitez","full_name":"Benitez, N.","first_name":"N."},{"last_name":"Bonoli","full_name":"Bonoli, S.","first_name":"S."},{"first_name":"S.","full_name":"Carneiro, S.","last_name":"Carneiro"},{"full_name":"Cenarro, J.","first_name":"J.","last_name":"Cenarro"},{"full_name":"Cristóbal-Hornillos, D.","first_name":"D.","last_name":"Cristóbal-Hornillos"},{"full_name":"Dupke, R.","first_name":"R.","last_name":"Dupke"},{"first_name":"A.","full_name":"Ederoclite, A.","last_name":"Ederoclite"},{"last_name":"Hernández-Monteagudo","first_name":"C.","full_name":"Hernández-Monteagudo, C."},{"first_name":"A.","full_name":"Marín-Franch, A.","last_name":"Marín-Franch"},{"full_name":"Mendes de Oliveira, C.","first_name":"C.","last_name":"Mendes de Oliveira"},{"last_name":"Moles","first_name":"M.","full_name":"Moles, M."},{"last_name":"Sodré","first_name":"L.","full_name":"Sodré, L."},{"last_name":"Taylor","full_name":"Taylor, K.","first_name":"K."},{"last_name":"Varela","first_name":"J.","full_name":"Varela, J."},{"last_name":"Vázquez Ramió","full_name":"Vázquez Ramió, H.","first_name":"H."}],"OA_place":"publisher","_id":"21380","DOAJ_listed":"1","title":"J-PAS: First identification, physical properties, and ionization efficiency of extreme emission line galaxies","has_accepted_license":"1","year":"2026","scopus_import":"1","publication":"Astronomy & Astrophysics","day":"01","department":[{"_id":"JoMa"}],"article_number":"A261","volume":706,"OA_type":"diamond","arxiv":1,"status":"public","file":[{"date_updated":"2026-03-02T14:51:57Z","relation":"main_file","file_size":1813456,"checksum":"cd25a05386ab5638ae5baf8add0ecbee","file_name":"2026_AstronomyAstrophysics_GimenezAlcazar.pdf","date_created":"2026-03-02T14:51:57Z","success":1,"content_type":"application/pdf","access_level":"open_access","file_id":"21391","creator":"dernst"}],"publication_status":"published","abstract":[{"lang":"eng","text":"Context. Extreme emission line galaxies (EELGs) are believed to significantly contribute to the star formation activity and mass assembly in galaxies. EELGs likely also play a leading role in the cosmic re-ionization as their interstellar medium may allow a significant fraction of their ionizing photons to escape (> 5%). Finding low-redshift analogues of these high-z galaxies is therefore essential to characterizing the physical conditions in the interstellar medium of these galaxies and understanding the processes that re-ionized the Universe.\r\n\r\nAims. We aimed to develop a robust and efficient method for the photometric identification of EELGs using the J-PAS survey. J-PAS will cover approximately 8500 deg2 of the sky with 54 narrow-band filters in the optical range plus i-SDSS, enabling detailed studies of the physical properties of these galaxies. In this work we focused on an initial subset of the survey: a 30 square degree area with complete observations in all bands.\r\n\r\nMethods. We combine equivalent width (EW) measurements from J-PAS narrow-band photometry with artificial intelligence techniques to identify galaxies with emission lines exceeding 300 Å. We validated our selection using spectroscopic data from DESI DR1 and characterized the selected sample through spectral energy distribution fitting with CIGALE.\r\n\r\nResults. We identify 917 EELGs up to z = 0.8 over 30 deg2, achieving a purity of 95% and a completeness of 96% for i-SDSS < 22.5 mag. Importantly, active galactic nucleus contamination was carefully considered and is estimated to be around 5%. Furthermore, a cross-match with DESI yielded 79 counterparts; their redshifts are in excellent agreement with our photometric estimates, thereby confirming the reliability of our redshift determination. In addition, the derived emission line fluxes are in good agreement with spectroscopic measurements. Moreover, the selected sample reveals strong correlations between the ionizing photon production efficiency (ξion) and EW(Hβ), which are consistent with previous observational studies at low and high redshifts and theoretical expectations. Finally, most of the sources surpass the ionizing efficiency threshold required for re-ionization, highlighting their relevance as local analogues of early-Universe galaxies."}],"intvolume":" 706","article_processing_charge":"No"},{"arxiv":1,"OA_type":"free access","article_number":"060901","volume":164,"department":[{"_id":"BiCh"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2512.18029"}],"publication":"The Journal of Chemical Physics","day":"14","title":"Long-range electrostatics for machine learning interatomic potentials is easier than we thought","year":"2026","scopus_import":"1","article_processing_charge":"No","intvolume":" 164","status":"public","publication_status":"published","abstract":[{"lang":"eng","text":"The lack of long-range electrostatics is a key limitation of modern machine learning interatomic potentials (MLIPs), hindering reliable applications to interfaces, charge-transfer reactions, polar and ionic materials, and biomolecules. In this Perspective, we distill two design principles behind the Latent Ewald Summation framework, which can capture long-range interactions, charges, and electrical response just by learning from standard energy and force training data: (i) use a Coulomb functional form with environment-dependent charges to capture electrostatic interactions, and (ii) avoid explicit training on ambiguous density functional theory partial charges. When both principles are satisfied, substantial flexibility remains: essentially any short-range MLIP can be augmented; charge equilibration schemes can be added when desired; dipoles and Born effective charges can be inferred or fine-tuned; and charge/spin-state embeddings or tensorial targets can be further incorporated. We also discuss current limitations and open challenges. Together, these minimal, physics-guided design rules suggest that incorporating long-range electrostatics into MLIPs is simpler and perhaps more broadly applicable than is commonly assumed."}],"language":[{"iso":"eng"}],"publisher":"AIP Publishing","date_published":"2026-02-14T00:00:00Z","doi":"10.1063/5.0316886","type":"journal_article","publication_identifier":{"eissn":["1089-7690"],"issn":["0021-9606"]},"external_id":{"arxiv":["2512.18029"]},"oa_version":"Preprint","date_created":"2026-03-02T10:06:46Z","month":"02","OA_place":"repository","_id":"21381","citation":{"apa":"Kim, D., & Cheng, B. (2026). Long-range electrostatics for machine learning interatomic potentials is easier than we thought. The Journal of Chemical Physics. AIP Publishing. https://doi.org/10.1063/5.0316886","mla":"Kim, Dongjin, and Bingqing Cheng. “Long-Range Electrostatics for Machine Learning Interatomic Potentials Is Easier than We Thought.” The Journal of Chemical Physics, vol. 164, no. 6, 060901, AIP Publishing, 2026, doi:10.1063/5.0316886.","ista":"Kim D, Cheng B. 2026. Long-range electrostatics for machine learning interatomic potentials is easier than we thought. The Journal of Chemical Physics. 164(6), 060901.","chicago":"Kim, Dongjin, and Bingqing Cheng. “Long-Range Electrostatics for Machine Learning Interatomic Potentials Is Easier than We Thought.” The Journal of Chemical Physics. AIP Publishing, 2026. https://doi.org/10.1063/5.0316886.","ama":"Kim D, Cheng B. Long-range electrostatics for machine learning interatomic potentials is easier than we thought. The Journal of Chemical Physics. 2026;164(6). doi:10.1063/5.0316886","ieee":"D. Kim and B. Cheng, “Long-range electrostatics for machine learning interatomic potentials is easier than we thought,” The Journal of Chemical Physics, vol. 164, no. 6. AIP Publishing, 2026.","short":"D. Kim, B. Cheng, The Journal of Chemical Physics 164 (2026)."},"issue":"6","acknowledgement":"B.C. thanks Christoph Dellago for his mentorship and influence. In addition to his seminal contributions to statistical mechanics, Christoph Dellago is an early developer and adopter of machine learning interatomic potentials. B.C. did two exchanges in the groups of Christoph Dellago and Jörg Behler in 2018, with transformative impact on her research directions.\r\n\r\nWe thank Peichen Zhong and Daniel S. King for useful feedback on the manuscript and for the collaborations on the LES method.\r\n\r\nFunding acknowledgment: Research reported in this publication was supported by the National Institute Of General Medical Sciences of the National Institutes of Health under Award No. R35GM159986. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.","author":[{"full_name":"Kim, Dongjin","first_name":"Dongjin","last_name":"Kim"},{"id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","orcid":"0000-0002-3584-9632","first_name":"Bingqing","full_name":"Cheng, Bingqing","last_name":"Cheng"}],"oa":1,"article_type":"original","date_updated":"2026-03-02T14:46:24Z","corr_author":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1"},{"article_processing_charge":"Yes","status":"public","publication_status":"published","abstract":[{"lang":"eng","text":"The exceptional energy-harvesting efficiency of lead-halide perovskites arises from unusually long photocarrier diffusion lengths and recombination lifetimes that persist even in defect-rich, solution-grown samples. Paradoxically, perovskites are also known for having very short exciton decay times. Here, we resolve this apparent contradiction by showing that key optoelectronic properties of perovskites can be explained by localized flexoelectric polarization confined to interfaces between domains of spontaneous strain. Using birefringence imaging, electrochemical staining, and zero-bias photocurrent measurements, we visualize the domain structure and directly probe the associated internal fields in nominally cubic single crystals of methylammonium lead bromide. We demonstrate that localized flexoelectric fields spatially separate electrons and holes to opposite sides of domain walls, exponentially suppressing recombination. Domain walls thus act as efficient mesoscopic transport channels for long-lived photocarriers, microscopically linking structural heterogeneity to charge transport and offering mechanistically informed design principles for perovskite solar-energy technologies."}],"file":[{"file_id":"21390","creator":"dernst","access_level":"open_access","file_name":"2026_NatureComm_Rak.pdf","date_created":"2026-03-02T14:27:56Z","content_type":"application/pdf","success":1,"date_updated":"2026-03-02T14:27:56Z","relation":"main_file","file_size":2570918,"checksum":"dd7a98de892d0b5abefca7e290ca0f77"}],"intvolume":" 17","PlanS_conform":"1","department":[{"_id":"ZhAl"},{"_id":"LifeSc"}],"volume":17,"article_number":"946","OA_type":"gold","has_accepted_license":"1","title":"Flexoelectric domain walls enable charge separation and transport in cubic perovskites","year":"2026","scopus_import":"1","publication":"Nature Communications","day":"16","acknowledgement":"We are grateful to A. G. Volosniev for the valuable discussions. We thank D. Milius for the assistance with microscopy. D. R. would like to thank F. Filakovský and T. Čuchráč for the valuable discussions. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF) and the Miba Machine Shop Facility (MS).","citation":{"ieee":"D. Rak, D. Lorenc, D. Balazs, A. A. Zhumekenov, O. M. Bakr, and Z. Alpichshev, “Flexoelectric domain walls enable charge separation and transport in cubic perovskites,” Nature Communications, vol. 17. Springer Nature, 2026.","short":"D. Rak, D. Lorenc, D. Balazs, A.A. Zhumekenov, O.M. Bakr, Z. Alpichshev, Nature Communications 17 (2026).","mla":"Rak, Dmytro, et al. “Flexoelectric Domain Walls Enable Charge Separation and Transport in Cubic Perovskites.” Nature Communications, vol. 17, 946, Springer Nature, 2026, doi:10.1038/s41467-026-68660-5.","apa":"Rak, D., Lorenc, D., Balazs, D., Zhumekenov, A. A., Bakr, O. M., & Alpichshev, Z. (2026). Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-68660-5","ama":"Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. 2026;17. doi:10.1038/s41467-026-68660-5","chicago":"Rak, Dmytro, Dusan Lorenc, Daniel Balazs, Ayan A. Zhumekenov, Osman M. Bakr, and Zhanybek Alpichshev. “Flexoelectric Domain Walls Enable Charge Separation and Transport in Cubic Perovskites.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-68660-5.","ista":"Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. 2026. Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. 17, 946."},"pmid":1,"author":[{"first_name":"Dmytro","full_name":"Rak, Dmytro","last_name":"Rak","id":"70313b46-47c2-11ec-9e88-cd79101918fe"},{"full_name":"Lorenc, Dusan","first_name":"Dusan","last_name":"Lorenc","id":"40D8A3E6-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Balazs","full_name":"Balazs, Daniel","first_name":"Daniel","orcid":"0000-0001-7597-043X","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E"},{"last_name":"Zhumekenov","full_name":"Zhumekenov, Ayan A.","first_name":"Ayan A."},{"last_name":"Bakr","full_name":"Bakr, Osman M.","first_name":"Osman M."},{"full_name":"Alpichshev, Zhanybek","first_name":"Zhanybek","last_name":"Alpichshev","orcid":"0000-0002-7183-5203","id":"45E67A2A-F248-11E8-B48F-1D18A9856A87"}],"OA_place":"publisher","acknowledged_ssus":[{"_id":"Bio"},{"_id":"M-Shop"}],"DOAJ_listed":"1","_id":"21382","corr_author":"1","quality_controlled":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_type":"original","date_updated":"2026-04-28T12:12:46Z","file_date_updated":"2026-03-02T14:27:56Z","doi":"10.1038/s41467-026-68660-5","type":"journal_article","language":[{"iso":"eng"}],"related_material":{"link":[{"url":"https://ista.ac.at/en/news/explaining-next-generation-solar-cells/","relation":"press_release","description":"News on ISTA website"}]},"publisher":"Springer Nature","date_published":"2026-02-16T00:00:00Z","oa_version":"Published Version","date_created":"2026-03-02T10:06:58Z","month":"02","ddc":["530"],"publication_identifier":{"eissn":["2041-1723"]},"external_id":{"pmid":["41698893"]}},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"date_updated":"2026-03-02T14:23:22Z","article_type":"original","oa":1,"author":[{"full_name":"Sasidharan, Vidyanand","first_name":"Vidyanand","last_name":"Sasidharan"},{"last_name":"Ancellotti","full_name":"Ancellotti, Laura","first_name":"Laura"},{"id":"034e0824-174b-11ef-b32b-9366a0e70d1c","last_name":"Doddihal","full_name":"Doddihal, Viraj","first_name":"Viraj"},{"last_name":"Brewster","full_name":"Brewster, Carolyn","first_name":"Carolyn"},{"first_name":"Frederick","full_name":"Mann, Frederick","last_name":"Mann"},{"first_name":"Mary Cathleen","full_name":"McKinney, Mary Cathleen","last_name":"McKinney"},{"first_name":"Joseph","full_name":"Varberg, Joseph","last_name":"Varberg"},{"first_name":"Eric","full_name":"Ross, Eric","last_name":"Ross"},{"first_name":"Fengyan","full_name":"Deng, Fengyan","last_name":"Deng"},{"last_name":"Yi","first_name":"Kexi","full_name":"Yi, Kexi"},{"first_name":"Alejandro","full_name":"Sánchez Alvarado, Alejandro","last_name":"Sánchez Alvarado"}],"issue":"6","acknowledgement":"We thank all the Sánchez Alvarado lab members for inputs and discussions. We are grateful to the Stowers Aquatics (particularly the Planarian team), Microscopy, and Molecular Biology core facilities for technical contributions and method development; e. n. lissek and A. Fujii from Oni US and S. Wang from the University of Missouri, Kansas city, for assistance with dStORM imaging; and d. Alburty and A. Page from innovaprep for assisting with the ntA. We also thank M. Miller for the illustrations. This work was supported by the hhMi and Stowers institute. ","citation":{"mla":"Sasidharan, Vidyanand, et al. “Extracellular Vesicles Mediate Stem Cell Signaling and Systemic RNAi in Planarians.” Science Advances, vol. 12, no. 6, eady1461, American Association for the Advancement of Science, 2026, doi:10.1126/sciadv.ady1461.","apa":"Sasidharan, V., Ancellotti, L., Doddihal, V., Brewster, C., Mann, F., McKinney, M. C., … Sánchez Alvarado, A. (2026). Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians. Science Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.ady1461","chicago":"Sasidharan, Vidyanand, Laura Ancellotti, Viraj Doddihal, Carolyn Brewster, Frederick Mann, Mary Cathleen McKinney, Joseph Varberg, et al. “Extracellular Vesicles Mediate Stem Cell Signaling and Systemic RNAi in Planarians.” Science Advances. American Association for the Advancement of Science, 2026. https://doi.org/10.1126/sciadv.ady1461.","ista":"Sasidharan V, Ancellotti L, Doddihal V, Brewster C, Mann F, McKinney MC, Varberg J, Ross E, Deng F, Yi K, Sánchez Alvarado A. 2026. Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians. Science Advances. 12(6), eady1461.","ama":"Sasidharan V, Ancellotti L, Doddihal V, et al. Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians. Science Advances. 2026;12(6). doi:10.1126/sciadv.ady1461","ieee":"V. Sasidharan et al., “Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians,” Science Advances, vol. 12, no. 6. American Association for the Advancement of Science, 2026.","short":"V. Sasidharan, L. Ancellotti, V. Doddihal, C. Brewster, F. Mann, M.C. McKinney, J. Varberg, E. Ross, F. Deng, K. Yi, A. Sánchez Alvarado, Science Advances 12 (2026)."},"_id":"21383","DOAJ_listed":"1","OA_place":"publisher","month":"02","date_created":"2026-03-02T10:08:07Z","oa_version":"Published Version","ddc":["570"],"publication_identifier":{"eissn":["2375-2548"]},"type":"journal_article","doi":"10.1126/sciadv.ady1461","file_date_updated":"2026-03-02T14:19:35Z","publisher":"American Association for the Advancement of Science","date_published":"2026-02-01T00:00:00Z","language":[{"iso":"eng"}],"file":[{"creator":"dernst","file_id":"21389","access_level":"open_access","success":1,"content_type":"application/pdf","date_created":"2026-03-02T14:19:35Z","file_name":"2026_ScienceAdv_Sasidharan.pdf","checksum":"fa9f6dafe3538e2d2872c098e06d1712","date_updated":"2026-03-02T14:19:35Z","relation":"main_file","file_size":2841345}],"publication_status":"published","abstract":[{"lang":"eng","text":"Planarian flatworms are known for their remarkable regenerative capacity; however, the precise intercellular communication mechanisms underlying this process remain unsolved. Here, we report the discovery and characterization of abundant extracellular vesicles (EVs) in planarians. Using imaging and molecular analysis, we show conservation of biogenesis, morphology, and protein composition of planarian EVs. Environmental stressors significantly elevate EV release, indicating that planarians dynamically regulate vesicle production. Functionally, planarian EVs mediate intercellular communication by transferring regulatory signals: We find that they shuttle small RNAs that effect systemic RNA interference (RNAi) throughout the organism. Notably, gene knockdown experiments reveal a crucial role for AGO-3, a member of the Argonaute family of proteins, in modulating the association of small interfering RNAs with EVs, linking the intracellular RNAi machinery to EV-based signaling. These findings highlight EVs as pivotal mediators of cell-cell communication in planarians, with broad implications for understanding the coordination of gene regulation and tissue regeneration in animals."}],"status":"public","intvolume":" 12","article_processing_charge":"Yes","license":"https://creativecommons.org/licenses/by-nc/4.0/","year":"2026","scopus_import":"1","title":"Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians","has_accepted_license":"1","day":"01","publication":"Science Advances","volume":12,"article_number":"eady1461","department":[{"_id":"CaHe"}],"OA_type":"gold"},{"month":"02","oa_version":"Published Version","date_created":"2026-03-02T10:08:38Z","external_id":{"pmid":["41632822"]},"publication_identifier":{"eissn":["1553-7358"]},"ddc":["570"],"project":[{"grant_number":"101071793","_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces"}],"type":"journal_article","doi":"10.1371/journal.pcbi.1013934","file_date_updated":"2026-03-02T14:11:14Z","publisher":"Public Library of Science","date_published":"2026-02-03T00:00:00Z","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_type":"original","date_updated":"2026-03-02T14:12:22Z","oa":1,"author":[{"full_name":"Liu, Jiayi","first_name":"Jiayi","last_name":"Liu"},{"last_name":"Ron","full_name":"Ron, Jonathan E.","first_name":"Jonathan E."},{"last_name":"Rinaldi","first_name":"Giulia","full_name":"Rinaldi, Giulia"},{"last_name":"Williantarra","first_name":"Ivanna","full_name":"Williantarra, Ivanna"},{"last_name":"Georgantzoglou","first_name":"Antonios","full_name":"Georgantzoglou, Antonios"},{"last_name":"de Vries","first_name":"Ingrid","full_name":"de Vries, Ingrid","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K","first_name":"Michael K","last_name":"Sixt"},{"last_name":"Sarris","full_name":"Sarris, Milka","first_name":"Milka"},{"full_name":"Gov, Nir S.","first_name":"Nir S.","last_name":"Gov"}],"pmid":1,"citation":{"ieee":"J. Liu et al., “Modelling chemotaxis of branched cells in complex environments provides insights into immune cell navigation,” PLOS Computational Biology, vol. 22, no. 2. Public Library of Science, 2026.","short":"J. Liu, J.E. Ron, G. Rinaldi, I. Williantarra, A. Georgantzoglou, I. de Vries, M.K. Sixt, M. Sarris, N.S. Gov, PLOS Computational Biology 22 (2026).","mla":"Liu, Jiayi, et al. “Modelling Chemotaxis of Branched Cells in Complex Environments Provides Insights into Immune Cell Navigation.” PLOS Computational Biology, vol. 22, no. 2, e1013934, Public Library of Science, 2026, doi:10.1371/journal.pcbi.1013934.","apa":"Liu, J., Ron, J. E., Rinaldi, G., Williantarra, I., Georgantzoglou, A., de Vries, I., … Gov, N. S. (2026). Modelling chemotaxis of branched cells in complex environments provides insights into immune cell navigation. PLOS Computational Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1013934","ama":"Liu J, Ron JE, Rinaldi G, et al. Modelling chemotaxis of branched cells in complex environments provides insights into immune cell navigation. PLOS Computational Biology. 2026;22(2). doi:10.1371/journal.pcbi.1013934","ista":"Liu J, Ron JE, Rinaldi G, Williantarra I, Georgantzoglou A, de Vries I, Sixt MK, Sarris M, Gov NS. 2026. Modelling chemotaxis of branched cells in complex environments provides insights into immune cell navigation. PLOS Computational Biology. 22(2), e1013934.","chicago":"Liu, Jiayi, Jonathan E. Ron, Giulia Rinaldi, Ivanna Williantarra, Antonios Georgantzoglou, Ingrid de Vries, Michael K Sixt, Milka Sarris, and Nir S. Gov. “Modelling Chemotaxis of Branched Cells in Complex Environments Provides Insights into Immune Cell Navigation.” PLOS Computational Biology. Public Library of Science, 2026. https://doi.org/10.1371/journal.pcbi.1013934."},"acknowledgement":"N.S.G. is the incumbent of the Lee and William Abramowitz Professorial Chair of Biophysics (Weizmann Institute), and acknowledges support from the Royal Society Wolfson Visiting Fellowship, and Human Frontier Science Program grant RGP0032/2022. Work by M.S., I.W., G.R. and A.G. was supported by the Leverhulme Trust (grant RPG-2021-226) and the European Research Council (ERC) under the Horizon 2020 program and UKRI, Grant agreement No.\r\nEP/Y02799X/1. M.S. and I.d.V acknowledge support by the European Research Council (grant ERC-SyG 101071793 to M.S). The funders had no role in study design, data collection and\r\nanalysis, decision to publish, or preparation of the manuscript.","issue":"2","_id":"21384","DOAJ_listed":"1","OA_place":"publisher","year":"2026","scopus_import":"1","title":"Modelling chemotaxis of branched cells in complex environments provides insights into immune cell navigation","has_accepted_license":"1","day":"03","publication":"PLOS Computational Biology","department":[{"_id":"MiSi"}],"article_number":"e1013934","volume":22,"OA_type":"gold","abstract":[{"lang":"eng","text":"Cell migration in vivo is often guided by chemical signaling, i.e., chemotaxis. For immune cells performing chemotaxis in the organism, this process is influenced by the complex geometry of the tissue environment. In this study, we use a theoretical model of branched cell migration on a network to explore the cellular response to chemical gradients. The model predicts the response of a branched cell to a chemical gradient: how the cell reorients its internal polarity and how it navigates through a complex environment up a chemical gradient. We then compare the model’s predictions with experimental observations of neutrophils migrating to the site of a laser-inflicted wound in a zebrafish larva fin, and neutrophils migrating in vitro inside a regular lattice of pillars. We find that the model captures the details of the subcellular response to the chemokine gradient, as well as qualitative characteristics of the large-scale migration, suggesting that the neutrophils behave as fast cells, which explains the functionality of these immune cells."}],"file":[{"content_type":"application/pdf","success":1,"date_created":"2026-03-02T14:11:14Z","file_name":"2026_PloSCompBio_.pdf","checksum":"564041089e7334804ad3cade973f80b4","date_updated":"2026-03-02T14:11:14Z","relation":"main_file","file_size":20688452,"creator":"dernst","file_id":"21388","access_level":"open_access"}],"publication_status":"published","status":"public","intvolume":" 22","PlanS_conform":"1","article_processing_charge":"Yes"},{"ec_funded":1,"OA_type":"hybrid","arxiv":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1017/prm.2026.10123"}],"department":[{"_id":"TiBr"}],"publication":"Proceedings of the Royal Society of Edinburgh: Section A Mathematics","year":"2026","title":"Average sizes of mixed character sums","has_accepted_license":"1","page":"1-15","article_processing_charge":"Yes (via OA deal)","PlanS_conform":"1","publication_status":"epub_ahead","abstract":[{"lang":"eng","text":"We prove that the average size of a mixed character sum (math. formular) (for a suitable smooth function w) is on the order of √x for all irrational real θ satisfying a weak Diophantine condition, where χ is drawn from the family of Dirichlet characters modulo a large prime r and where x 6 r. In contrast, it was proved by Harper that the average size is o(√x) for rational θ. Certain quadratic Diophantine equations play a key role in the present paper. "}],"status":"public","date_published":"2026-01-01T00:00:00Z","publisher":"Cambridge University Press","language":[{"iso":"eng"}],"type":"journal_article","doi":"10.1017/prm.2026.10123","external_id":{"arxiv":["2411.14181"]},"ddc":["510"],"publication_identifier":{"eissn":["1473-7124"],"issn":["0308-2105"]},"project":[{"name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","call_identifier":"H2020"}],"month":"01","date_created":"2026-03-02T10:09:23Z","oa_version":"Published Version","_id":"21385","OA_place":"publisher","author":[{"first_name":"Victor","full_name":"Wang, Victor","last_name":"Wang","orcid":"0000-0002-0704-7026","id":"76096395-aea4-11ed-a680-ab8ebbd3f1b9"},{"last_name":"Xu","full_name":"Xu, Max","first_name":"Max"}],"acknowledgement":"We thank Ofir Gorodetsky, Andrew Granville, Adam Harper, Youness Lamzouri,\r\nKannan Soundararajan, Ping Xi, and Matt Young for their interest, helpful discussions, and comments. Special thanks are due to Jonathan Bober, Oleksiy Klurman,\r\nand Besfort Shala for sending us a letter about Question 1.3, and to Hung Bui\r\nfor informing us of [7]. V.W. thanks Stanford University for its hospitality and is supported by the European Union’s Horizon 2020 research and innovation program\r\nunder the Marie Skłodowska–Curie Grant Agreement No. 101034413. M.X. is supported by a Simons Junior Fellowship from the Simons Society of Fellows at the\r\nSimons Foundation.","citation":{"apa":"Wang, V., & Xu, M. (2026). Average sizes of mixed character sums. Proceedings of the Royal Society of Edinburgh: Section A Mathematics. Cambridge University Press. https://doi.org/10.1017/prm.2026.10123","mla":"Wang, Victor, and Max Xu. “Average Sizes of Mixed Character Sums.” Proceedings of the Royal Society of Edinburgh: Section A Mathematics, Cambridge University Press, 2026, pp. 1–15, doi:10.1017/prm.2026.10123.","ama":"Wang V, Xu M. Average sizes of mixed character sums. Proceedings of the Royal Society of Edinburgh: Section A Mathematics. 2026:1-15. doi:10.1017/prm.2026.10123","ista":"Wang V, Xu M. 2026. Average sizes of mixed character sums. Proceedings of the Royal Society of Edinburgh: Section A Mathematics., 1–15.","chicago":"Wang, Victor, and Max Xu. “Average Sizes of Mixed Character Sums.” Proceedings of the Royal Society of Edinburgh: Section A Mathematics. Cambridge University Press, 2026. https://doi.org/10.1017/prm.2026.10123.","ieee":"V. Wang and M. Xu, “Average sizes of mixed character sums,” Proceedings of the Royal Society of Edinburgh: Section A Mathematics. Cambridge University Press, pp. 1–15, 2026.","short":"V. Wang, M. Xu, Proceedings of the Royal Society of Edinburgh: Section A Mathematics (2026) 1–15."},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_type":"original","date_updated":"2026-03-02T14:05:47Z","oa":1,"quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","corr_author":"1"},{"abstract":[{"text":"This thesis documents a voyage towards truth and beauty via formal verification of theorems. To this end, we develop libraries in Lean 4 that present definitions and results from diverse areas of MathematiCS (i.e., Mathematics and Computer Science). The aim is to create code that is understandable, believable, useful, and elegant. The code should stand for itself as much as possible without a need for documentation; however, this text redundantly documents our code artifacts and provides additional context that isn’t present in the code. This thesis is written for readers who know Lean 4 but are not familiar with any of the topics presented. We manifest truth and beauty in three formalized areas of MathematiCS.\r\n\r\nWe formalize general grammars in Lean 4 and use grammars to show closure of the class of type-0 languages under four operations; union, reversal, concatenation, and the Kleene star.\r\n\r\nOur second stop is the theory of optimization. Farkas established that a system of linear inequalities has a solution if and only if we cannot obtain a contradiction by taking a linear combination of the inequalities. We state and formally prove several Farkas-like theorems over linearly ordered fields in Lean 4. Furthermore, we extend duality theory to the case when some coefficients are allowed to take “infinite values”. Additionally, we develop the basics of the theory of optimization in terms of the framework called General-Valued Constraint Satisfaction Problems, and we prove that, if a Rational-Valued Constraint Satisfaction Problem template has symmetric fractional polymorphisms of all arities, then its basic LP relaxation is tight.\r\n\r\nOur third stop is matroid theory. Seymour’s decomposition theorem is a hallmark result in matroid theory, presenting a structural characterization of the class of regular matroids. We aim to formally verify Seymour’s theorem in Lean 4. First, we build a library for working with totally unimodular matrices. We define binary matroids and their standard representations, and we prove that they form a matroid in the sense how Mathlib defines matroids. We define regular matroids to be matroids for which there exists a full representation rational matrix that is totally unimodular, and we prove that all regular matroids are binary. We define 1-sum, 2-sum, and 3 sum of binary matroids as specific ways to compose their standard representation matrices. We prove that the 1-sum, the 2-sum, and the 3-sum of regular matroids are a regular matroid, which concludes the composition direction of the Seymour’s theorem. The (more difficult) decomposition direction remains unproved.\r\n\r\nIn the pursuit of truth, we focus on identifying the trusted code in each project and presenting it faithfully. We emphasize the readability and believability of definitions rather than choosing definitions that are easier to work with. In search for beauty, we focus on the philosophical framework of Roger Scruton, who emphasizes that beauty is not a mere decoration but, most importantly, beauty is the means for shaping our place in the world and a source of redemption, where it can be viewed as a substitute for religion.","lang":"eng"}],"publication_status":"published","file":[{"creator":"mdvorak","file_id":"21394","access_level":"open_access","content_type":"application/pdf","success":1,"file_name":"2026_Dvorak_Martin_Thesis.pdf","date_created":"2026-03-04T08:56:15Z","checksum":"cface6dc18152680962b5361575f6e4f","relation":"main_file","file_size":1771231,"date_updated":"2026-03-04T08:56:15Z"},{"date_created":"2026-03-04T09:03:37Z","file_name":"2026_Dvorak_Martin_Thesis.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_updated":"2026-03-04T09:03:37Z","relation":"source_file","file_size":864585,"checksum":"290ddfacfb7e07fb07e6f0b334e67c90","file_id":"21395","creator":"mdvorak","access_level":"closed"}],"status":"public","article_processing_charge":"No","page":"160","year":"2026","has_accepted_license":"1","title":"Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids","day":"04","department":[{"_id":"GradSch"},{"_id":"VlKo"}],"alternative_title":["ISTA Thesis"],"degree_awarded":"PhD","corr_author":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","supervisor":[{"id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kolmogorov","full_name":"Kolmogorov, Vladimir","first_name":"Vladimir"},{"last_name":"Blanchette","first_name":"Jasmin","full_name":"Blanchette, Jasmin"}],"oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_updated":"2026-03-27T12:37:00Z","author":[{"id":"40ED02A8-C8B4-11E9-A9C0-453BE6697425","orcid":"0000-0001-5293-214X","last_name":"Dvorak","first_name":"Martin","full_name":"Dvorak, Martin"}],"citation":{"ieee":"M. Dvorak, “Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids,” Institute of Science and Technology Austria, 2026.","short":"M. Dvorak, Pursuit of Truth and Beauty in Lean 4 : Formally Verified Theory of Grammars, Optimization, Matroids, Institute of Science and Technology Austria, 2026.","apa":"Dvorak, M. (2026). Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21393","mla":"Dvorak, Martin. Pursuit of Truth and Beauty in Lean 4 : Formally Verified Theory of Grammars, Optimization, Matroids. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21393.","ista":"Dvorak M. 2026. Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids. Institute of Science and Technology Austria.","chicago":"Dvorak, Martin. “Pursuit of Truth and Beauty in Lean 4 : Formally Verified Theory of Grammars, Optimization, Matroids.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21393.","ama":"Dvorak M. Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids. 2026. doi:10.15479/AT-ISTA-21393"},"_id":"21393","OA_place":"repository","month":"03","oa_version":"Published Version","date_created":"2026-03-04T09:26:46Z","ddc":["511","000"],"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-074-9"]},"doi":"10.15479/AT-ISTA-21393","file_date_updated":"2026-03-04T09:03:37Z","type":"dissertation","publisher":"Institute of Science and Technology Austria","date_published":"2026-03-04T00:00:00Z","language":[{"iso":"eng"}],"related_material":{"record":[{"status":"public","id":"13120","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"21398","status":"public"},{"relation":"part_of_dissertation","id":"20071","status":"public"}],"link":[{"description":"Full version of all definitions, statements, and proofs for Chapter 3.1 (Linear duality)","relation":"software","url":"https://github.com/madvorak/duality/tree/v3.5.0"},{"description":"Full version of all definitions, statements, and proofs for Chapter 3.2 (Valued Constraint Satisfaction Problems)","url":"https://github.com/madvorak/vcsp/tree/v8.2.0","relation":"software"},{"description":"Full version of all definitions, statements, and proofs for Chapter 4 (Seymour project)","relation":"software","url":"https://github.com/Ivan-Sergeyev/seymour/tree/v1.2.0"},{"relation":"software","url":"https://github.com/madvorak/chomsky/tree/v1.2.0","description":"Full version of all definitions, statements, and proofs for Chapter 5 (Theory of grammars)"},{"relation":"software","url":"https://github.com/madvorak/grammars","description":"Old version (Lean 3) of the project about grammars"},{"relation":"software","url":"https://github.com/madvorak/preliminaries/blob/main/Preliminaries.lean","description":"Demonstration of (minimal) requirements for selected algebraic classes used in my Ph.D. thesis"}]}},{"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_updated":"2026-03-09T15:14:18Z","oa":1,"abstract":[{"lang":"eng","text":"This document is a blueprint for the formalization in Lean of the structural theory of regular matroids underlying Seymour's decomposition theorem. We present a modular account of regularity via totally unimodular representations, show that regularity is preserved under 1-, 2-, and 3-sums, and establish regularity for several special classes of matroids, including graphic, cographic, and the matroid R10. The blueprint records the logical structure of the proof, the precise dependencies between results, and their correspondence with Lean declarations. It is intended both as a guide for the ongoing formalization effort and as a human-readable reference for the organization of the proof."}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publication_status":"submitted","corr_author":"1","status":"public","_id":"21400","page":"18","OA_place":"repository","article_processing_charge":"No","author":[{"orcid":"0009-0004-9145-8785","last_name":"Sergeev","full_name":"Sergeev, Ivan","first_name":"Ivan","id":"ca3c9187-9a72-11ee-a009-8af825d896b0"},{"id":"40ED02A8-C8B4-11E9-A9C0-453BE6697425","full_name":"Dvorak, Martin","first_name":"Martin","last_name":"Dvorak","orcid":"0000-0001-5293-214X"},{"last_name":"Rampell","full_name":"Rampell, Cameron","first_name":"Cameron"},{"last_name":"Sandey","first_name":"Mark","full_name":"Sandey, Mark"},{"first_name":"Pietro","full_name":"Monticone, Pietro","last_name":"Monticone"}],"citation":{"mla":"Sergeev, Ivan, et al. “A Blueprint for the Formalization of Seymour’s Matroid Decomposition Theorem.” ArXiv, doi:10.48550/arXiv.2601.01255.","apa":"Sergeev, I., Dvorak, M., Rampell, C., Sandey, M., & Monticone, P. (n.d.). A blueprint for the formalization of Seymour’s matroid decomposition theorem. arXiv. https://doi.org/10.48550/arXiv.2601.01255","chicago":"Sergeev, Ivan, Martin Dvorak, Cameron Rampell, Mark Sandey, and Pietro Monticone. “A Blueprint for the Formalization of Seymour’s Matroid Decomposition Theorem.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2601.01255.","ista":"Sergeev I, Dvorak M, Rampell C, Sandey M, Monticone P. A blueprint for the formalization of Seymour’s matroid decomposition theorem. arXiv, 10.48550/arXiv.2601.01255.","ama":"Sergeev I, Dvorak M, Rampell C, Sandey M, Monticone P. A blueprint for the formalization of Seymour’s matroid decomposition theorem. arXiv. doi:10.48550/arXiv.2601.01255","ieee":"I. Sergeev, M. Dvorak, C. Rampell, M. Sandey, and P. Monticone, “A blueprint for the formalization of Seymour’s matroid decomposition theorem,” arXiv. .","short":"I. Sergeev, M. Dvorak, C. Rampell, M. Sandey, P. Monticone, ArXiv (n.d.)."},"day":"03","external_id":{"arxiv":["2601.01255"]},"publication":"arXiv","month":"01","year":"2026","title":"A blueprint for the formalization of Seymour's matroid decomposition theorem","date_created":"2026-03-04T12:09:26Z","oa_version":"Preprint","date_published":"2026-01-03T00:00:00Z","related_material":{"link":[{"relation":"supplementary_material","url":"https://ivan-sergeyev.github.io/seymour/blueprint.pdf"}]},"arxiv":1,"language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2601.01255","open_access":"1"}],"department":[{"_id":"GradSch"},{"_id":"VlKo"}],"type":"preprint","doi":"10.48550/arXiv.2601.01255"},{"type":"dissertation","file_date_updated":"2026-03-10T15:20:09Z","doi":"10.15479/AT-ISTA-21401","publisher":"Institute of Science and Technology Austria","date_published":"2026-03-05T00:00:00Z","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"21020"}]},"language":[{"iso":"eng"}],"month":"03","oa_version":"Published Version","date_created":"2026-03-05T15:20:47Z","ddc":["000"],"publication_identifier":{"issn":["2791-4585"]},"project":[{"call_identifier":"H2020","grant_number":"101020093","name":"Vigilant Algorithmic Monitoring of Software","_id":"62781420-2b32-11ec-9570-8d9b63373d4d"},{"grant_number":"F8512","name":"Security and Privacy by Design for Complex Systems","_id":"34a4ce89-11ca-11ed-8bc3-8cc37fb6e11f"}],"author":[{"id":"6e5417ba-5355-11ee-ae5a-94c2e510b26b","first_name":"Mahyar","full_name":"Karimi, Mahyar","last_name":"Karimi","orcid":"0009-0005-0820-1696"}],"citation":{"chicago":"Karimi, Mahyar. “Privacy-Preserving Runtime Verification.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21401.","ama":"Karimi M. Privacy-preserving runtime verification. 2026. doi:10.15479/AT-ISTA-21401","ista":"Karimi M. 2026. Privacy-preserving runtime verification. Institute of Science and Technology Austria.","mla":"Karimi, Mahyar. Privacy-Preserving Runtime Verification. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21401.","apa":"Karimi, M. (2026). Privacy-preserving runtime verification. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21401","short":"M. Karimi, Privacy-Preserving Runtime Verification, Institute of Science and Technology Austria, 2026.","ieee":"M. Karimi, “Privacy-preserving runtime verification,” Institute of Science and Technology Austria, 2026."},"acknowledgement":"This work is part of the project VAMOS, which has received funding from the European\r\nResearch Council (ERC) under grant agreement No. 101020093, and the Austrian Science\r\nFund (FWF) SFB project SpyCoDe F8502.\r\n","_id":"21401","OA_place":"repository","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","corr_author":"1","keyword":["Privacy-preserving verification","Runtime verification","Monitoring","Reactive functionalities","Cryptographic protocols"],"supervisor":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","first_name":"Thomas A","full_name":"Henzinger, Thomas A","orcid":"0000-0002-2985-7724"}],"date_updated":"2026-03-13T13:37:20Z","oa":1,"department":[{"_id":"GradSch"},{"_id":"ToHe"}],"ec_funded":1,"alternative_title":["ISTA Master’s Thesis"],"degree_awarded":"MS","year":"2026","has_accepted_license":"1","title":"Privacy-preserving runtime verification","day":"05","article_processing_charge":"No","page":"60","publication_status":"published","abstract":[{"lang":"eng","text":"Runtime verification offers scalable solutions to improve the safety and reliability of systems. However, systems that require verification or monitoring by a third party to ensure compliance with a specification might contain sensitive information, causing privacy concerns when usual runtime verification approaches are used. Privacy is compromised if protected information about the system, or sensitive data that is processed by the system, is revealed. In addition, revealing the specification being monitored may undermine the essence of third-party verification.\r\n\r\nIn this thesis, we propose a protocol for privacy-preserving runtime verification of systems against formal sequential specifications. We develop the protocol in two steps. In the first step, the monitor verifies whether the system satisfies the specification without learning anything else, though both parties are aware of the specification. In the second step, we extend the protocol to ensure that the system remains oblivious to the monitored specification, while the monitor learns only whether the system satisfies the specification and nothing more. Our protocol adapts and improves existing techniques used in cryptography, and more specifically, multi-party computation.\r\n\r\nThe sequential specification defines the observation step of the monitor, whose granularity depends on the situation (e.g., banks may be monitored on a daily basis). Our protocol exchanges a single message per observation step, after an initialization phase. This design minimizes communication overhead, enabling relatively lightweight privacy-preserving monitoring. We implement our approach for monitoring specifications described by register automata and evaluate it experimentally.\r\n"}],"file":[{"creator":"mkarimi","file_id":"21404","access_level":"open_access","content_type":"application/pdf","date_created":"2026-03-06T14:06:25Z","file_name":"2026_Karimi_Mahyar_Thesis.pdf","checksum":"3f49f05c9d123e14d7adb73d3bc50fe2","relation":"main_file","date_updated":"2026-03-10T15:20:09Z","file_size":766048},{"access_level":"closed","creator":"mkarimi","file_id":"21405","checksum":"8fb9db4b4187e26443369a993427a5ff","relation":"source_file","file_size":1243394,"date_updated":"2026-03-06T14:06:25Z","content_type":"application/zip","file_name":"2026_Karimi_Mahyar_Thesis_src.zip","date_created":"2026-03-06T14:06:25Z"}],"status":"public"}]