[{"oa_version":"None","issue":"40","quality_controlled":"1","intvolume":"        51","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","title":"Challenges facing Lithium batteries and electrical double-layer capacitors","article_type":"original","type":"journal_article","year":"2012","page":"9994-10024","publisher":"Wiley","month":"10","publication_status":"published","abstract":[{"text":"Energy‐storage technologies, including electrical double‐layer capacitors and rechargeable batteries, have attracted significant attention for applications in portable electronic devices, electric vehicles, bulk electricity storage at power stations, and “load leveling” of renewable sources, such as solar energy and wind power. Transforming lithium batteries and electric double‐layer capacitors requires a step change in the science underpinning these devices, including the discovery of new materials, new electrochemistry, and an increased understanding of the processes on which the devices depend. The Review will consider some of the current scientific issues underpinning lithium batteries and electric double‐layer capacitors.","lang":"eng"}],"date_updated":"2021-01-12T08:12:56Z","article_processing_charge":"No","extern":"1","day":"01","language":[{"iso":"eng"}],"date_published":"2012-10-01T00:00:00Z","doi":"10.1002/anie.201201429","publication":"Angewandte Chemie International Edition","volume":51,"publication_identifier":{"issn":["1433-7851"]},"date_created":"2020-01-15T12:19:11Z","citation":{"mla":"Choi, Nam-Soon, et al. “Challenges Facing Lithium Batteries and Electrical Double-Layer Capacitors.” <i>Angewandte Chemie International Edition</i>, vol. 51, no. 40, Wiley, 2012, pp. 9994–10024, doi:<a href=\"https://doi.org/10.1002/anie.201201429\">10.1002/anie.201201429</a>.","chicago":"Choi, Nam-Soon, Zonghai Chen, Stefan Alexander Freunberger, Xiulei Ji, Yang-Kook Sun, Khalil Amine, Gleb Yushin, Linda F. Nazar, Jaephil Cho, and Peter G. Bruce. “Challenges Facing Lithium Batteries and Electrical Double-Layer Capacitors.” <i>Angewandte Chemie International Edition</i>. Wiley, 2012. <a href=\"https://doi.org/10.1002/anie.201201429\">https://doi.org/10.1002/anie.201201429</a>.","apa":"Choi, N.-S., Chen, Z., Freunberger, S. A., Ji, X., Sun, Y.-K., Amine, K., … Bruce, P. G. (2012). Challenges facing Lithium batteries and electrical double-layer capacitors. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.201201429\">https://doi.org/10.1002/anie.201201429</a>","ista":"Choi N-S, Chen Z, Freunberger SA, Ji X, Sun Y-K, Amine K, Yushin G, Nazar LF, Cho J, Bruce PG. 2012. Challenges facing Lithium batteries and electrical double-layer capacitors. Angewandte Chemie International Edition. 51(40), 9994–10024.","ama":"Choi N-S, Chen Z, Freunberger SA, et al. Challenges facing Lithium batteries and electrical double-layer capacitors. <i>Angewandte Chemie International Edition</i>. 2012;51(40):9994-10024. doi:<a href=\"https://doi.org/10.1002/anie.201201429\">10.1002/anie.201201429</a>","short":"N.-S. Choi, Z. Chen, S.A. Freunberger, X. Ji, Y.-K. Sun, K. Amine, G. Yushin, L.F. Nazar, J. Cho, P.G. Bruce, Angewandte Chemie International Edition 51 (2012) 9994–10024.","ieee":"N.-S. Choi <i>et al.</i>, “Challenges facing Lithium batteries and electrical double-layer capacitors,” <i>Angewandte Chemie International Edition</i>, vol. 51, no. 40. Wiley, pp. 9994–10024, 2012."},"_id":"7309","author":[{"full_name":"Choi, Nam-Soon","first_name":"Nam-Soon","last_name":"Choi"},{"first_name":"Zonghai","last_name":"Chen","full_name":"Chen, Zonghai"},{"full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","first_name":"Stefan Alexander","last_name":"Freunberger","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"},{"full_name":"Ji, Xiulei","last_name":"Ji","first_name":"Xiulei"},{"first_name":"Yang-Kook","last_name":"Sun","full_name":"Sun, Yang-Kook"},{"first_name":"Khalil","last_name":"Amine","full_name":"Amine, Khalil"},{"first_name":"Gleb","last_name":"Yushin","full_name":"Yushin, Gleb"},{"last_name":"Nazar","first_name":"Linda F.","full_name":"Nazar, Linda F."},{"full_name":"Cho, Jaephil","last_name":"Cho","first_name":"Jaephil"},{"full_name":"Bruce, Peter G.","first_name":"Peter G.","last_name":"Bruce"}]},{"date_created":"2020-01-15T12:19:23Z","publication_identifier":{"issn":["0036-8075","1095-9203"]},"volume":337,"publication":"Science","_id":"7310","citation":{"ieee":"Z. Peng, S. A. Freunberger, Y. Chen, and P. G. Bruce, “A reversible and higher-rate Li-O2 battery,” <i>Science</i>, vol. 337, no. 6094. AAAS, pp. 563–566, 2012.","short":"Z. Peng, S.A. Freunberger, Y. Chen, P.G. Bruce, Science 337 (2012) 563–566.","ama":"Peng Z, Freunberger SA, Chen Y, Bruce PG. A reversible and higher-rate Li-O2 battery. <i>Science</i>. 2012;337(6094):563-566. doi:<a href=\"https://doi.org/10.1126/science.1223985\">10.1126/science.1223985</a>","apa":"Peng, Z., Freunberger, S. A., Chen, Y., &#38; Bruce, P. G. (2012). A reversible and higher-rate Li-O2 battery. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.1223985\">https://doi.org/10.1126/science.1223985</a>","ista":"Peng Z, Freunberger SA, Chen Y, Bruce PG. 2012. A reversible and higher-rate Li-O2 battery. Science. 337(6094), 563–566.","chicago":"Peng, Z., Stefan Alexander Freunberger, Y. Chen, and P. G. Bruce. “A Reversible and Higher-Rate Li-O2 Battery.” <i>Science</i>. AAAS, 2012. <a href=\"https://doi.org/10.1126/science.1223985\">https://doi.org/10.1126/science.1223985</a>.","mla":"Peng, Z., et al. “A Reversible and Higher-Rate Li-O2 Battery.” <i>Science</i>, vol. 337, no. 6094, AAAS, 2012, pp. 563–66, doi:<a href=\"https://doi.org/10.1126/science.1223985\">10.1126/science.1223985</a>."},"author":[{"first_name":"Z.","last_name":"Peng","full_name":"Peng, Z."},{"id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","first_name":"Stefan Alexander","last_name":"Freunberger"},{"full_name":"Chen, Y.","first_name":"Y.","last_name":"Chen"},{"full_name":"Bruce, P. G.","last_name":"Bruce","first_name":"P. G."}],"day":"03","extern":"1","article_processing_charge":"No","language":[{"iso":"eng"}],"doi":"10.1126/science.1223985","date_published":"2012-08-03T00:00:00Z","year":"2012","page":"563-566","month":"08","publisher":"AAAS","date_updated":"2021-01-12T08:12:57Z","abstract":[{"text":"The rechargeable nonaqueous lithium-air (Li-O2) battery is receiving a great deal of interest because, theoretically, its specific energy far exceeds the best that can be achieved with lithium-ion cells. Operation of the rechargeable Li-O2 battery depends critically on repeated and highly reversible formation/decomposition of lithium peroxide (Li2O2) at the cathode upon cycling. Here, we show that this process is possible with the use of a dimethyl sulfoxide electrolyte and a porous gold electrode (95% capacity retention from cycles 1 to 100), whereas previously only partial Li2O2 formation/decomposition and limited cycling could occur. Furthermore, we present data indicating that the kinetics of Li2O2 oxidation on charge is approximately 10 times faster than on carbon electrodes.","lang":"eng"}],"publication_status":"published","quality_controlled":"1","issue":"6094","oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"       337","article_type":"original","type":"journal_article","title":"A reversible and higher-rate Li-O2 battery","status":"public"},{"date_created":"2020-01-15T12:19:36Z","publication_identifier":{"issn":["0002-7863","1520-5126"]},"publication":"Journal of the American Chemical Society","volume":134,"author":[{"first_name":"Yuhui","last_name":"Chen","full_name":"Chen, Yuhui"},{"first_name":"Stefan Alexander","last_name":"Freunberger","orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"},{"first_name":"Zhangquan","last_name":"Peng","full_name":"Peng, Zhangquan"},{"full_name":"Bardé, Fanny","last_name":"Bardé","first_name":"Fanny"},{"full_name":"Bruce, Peter G.","first_name":"Peter G.","last_name":"Bruce"}],"_id":"7311","citation":{"ieee":"Y. Chen, S. A. Freunberger, Z. Peng, F. Bardé, and P. G. Bruce, “Li–O2 battery with a dimethylformamide electrolyte,” <i>Journal of the American Chemical Society</i>, vol. 134, no. 18. ACS, pp. 7952–7957, 2012.","apa":"Chen, Y., Freunberger, S. A., Peng, Z., Bardé, F., &#38; Bruce, P. G. (2012). Li–O2 battery with a dimethylformamide electrolyte. <i>Journal of the American Chemical Society</i>. ACS. <a href=\"https://doi.org/10.1021/ja302178w\">https://doi.org/10.1021/ja302178w</a>","ista":"Chen Y, Freunberger SA, Peng Z, Bardé F, Bruce PG. 2012. Li–O2 battery with a dimethylformamide electrolyte. Journal of the American Chemical Society. 134(18), 7952–7957.","short":"Y. Chen, S.A. Freunberger, Z. Peng, F. Bardé, P.G. Bruce, Journal of the American Chemical Society 134 (2012) 7952–7957.","ama":"Chen Y, Freunberger SA, Peng Z, Bardé F, Bruce PG. Li–O2 battery with a dimethylformamide electrolyte. <i>Journal of the American Chemical Society</i>. 2012;134(18):7952-7957. doi:<a href=\"https://doi.org/10.1021/ja302178w\">10.1021/ja302178w</a>","mla":"Chen, Yuhui, et al. “Li–O2 Battery with a Dimethylformamide Electrolyte.” <i>Journal of the American Chemical Society</i>, vol. 134, no. 18, ACS, 2012, pp. 7952–57, doi:<a href=\"https://doi.org/10.1021/ja302178w\">10.1021/ja302178w</a>.","chicago":"Chen, Yuhui, Stefan Alexander Freunberger, Zhangquan Peng, Fanny Bardé, and Peter G. Bruce. “Li–O2 Battery with a Dimethylformamide Electrolyte.” <i>Journal of the American Chemical Society</i>. ACS, 2012. <a href=\"https://doi.org/10.1021/ja302178w\">https://doi.org/10.1021/ja302178w</a>."},"day":"19","article_processing_charge":"No","extern":"1","doi":"10.1021/ja302178w","date_published":"2012-04-19T00:00:00Z","language":[{"iso":"eng"}],"year":"2012","page":"7952-7957","date_updated":"2021-01-12T08:12:58Z","abstract":[{"text":"Stability of the electrolyte toward reduced oxygen species generated at the cathode is a crucial challenge for the rechargeable nonaqueous Li–O2 battery. Here, we investigate dimethylformamide as the basis of an electrolyte. Although reactions at the O2 cathode on the first discharge–charge cycle are dominated by reversible Li2O2 formation/decomposition, there is also electrolyte decomposition, which increases on cycling. The products of decomposition at the cathode on discharge are Li2O2, Li2CO3, HCO2Li, CH3CO2Li, NO, H2O, and CO2. Li2CO3 accumulates in the electrode with cycling. The stability of dimethylformamide toward reduced oxygen species is insufficient for its use in the rechargeable nonaqueous Li–O2 battery.","lang":"eng"}],"publication_status":"published","month":"04","publisher":"ACS","issue":"18","quality_controlled":"1","oa_version":"None","type":"journal_article","article_type":"original","title":"Li–O2 battery with a dimethylformamide electrolyte","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"       134"},{"publication_status":"published","date_updated":"2021-01-12T07:41:05Z","abstract":[{"text":"\nGradients of the plant hormone auxin, which depend on its active intercellular transport, are crucial for the maintenance of root meristematic activity. This directional transport is largely orchestrated by a complex interaction of specific influx and efflux carriers that mediate the auxin flow into and out of cells, respectively. Besides these transport proteins, plant-specific polyphenolic compounds knownasflavonols have beenshownto act as endogenous regulators of auxin transport. However, only limited information is available on how flavonol synthesis is developmentally regulated. Using reduction-of-function and overexpression approaches in parallel, we demonstrate that the WRKY23 transcription factor is needed for proper root growth and development by stimulating the local biosynthesis of flavonols. The expression of WRKY23 itself is controlled by auxin through the AUXIN RESPONSE FACTOR 7 (ARF7) and ARF19 transcriptional response pathway. Our results suggest a model in which WRKY23 is part of a transcriptional feedback loop of auxin on its own transport through local regulation of flavonol biosynthesis.","lang":"eng"}],"publisher":"National Academy of Sciences","month":"01","year":"2012","page":"1554 - 1559","publist_id":"3595","title":"Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis","status":"public","type":"journal_article","intvolume":"       109","quality_controlled":0,"issue":"5","author":[{"first_name":"Wim","last_name":"Grunewald","full_name":"Grunewald, Wim"},{"full_name":"De Smet, Ive","first_name":"Ive","last_name":"De Smet"},{"full_name":"Lewis, Daniel R","last_name":"Lewis","first_name":"Daniel"},{"last_name":"Löfke","first_name":"Christian","full_name":"Löfke, Christian"},{"full_name":"Jansen, Leentje","last_name":"Jansen","first_name":"Leentje"},{"first_name":"Geert","last_name":"Goeminne","full_name":"Goeminne, Geert"},{"full_name":"Vanden Bossche, Robin","last_name":"Vanden Bossche","first_name":"Robin"},{"last_name":"Karimi","first_name":"Mansour","full_name":"Karimi, Mansour"},{"first_name":"Bert","last_name":"De Rybel","full_name":"De Rybel, Bert"},{"last_name":"Vanholme","first_name":"Bartel","full_name":"Vanholme, Bartel"},{"first_name":"Thomas","last_name":"Teichmann","full_name":"Teichmann, Thomas"},{"full_name":"Boerjan, Wout","last_name":"Boerjan","first_name":"Wout"},{"full_name":"Van Montagu, Marc C","last_name":"Van Montagu","first_name":"Marc"},{"full_name":"Gheysen, Godelieve","first_name":"Godelieve","last_name":"Gheysen"},{"first_name":"Gloria","last_name":"Muday","full_name":"Muday, Gloria K"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jirí","orcid":"0000-0002-8302-7596","full_name":"Jirí Friml"},{"first_name":"Tom","last_name":"Beeckman","full_name":"Beeckman, Tom"}],"citation":{"ama":"Grunewald W, De Smet I, Lewis D, et al. Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis. <i>PNAS</i>. 2012;109(5):1554-1559. doi:<a href=\"https://doi.org/10.1073/pnas.1121134109\">10.1073/pnas.1121134109</a>","short":"W. Grunewald, I. De Smet, D. Lewis, C. Löfke, L. Jansen, G. Goeminne, R. Vanden Bossche, M. Karimi, B. De Rybel, B. Vanholme, T. Teichmann, W. Boerjan, M. Van Montagu, G. Gheysen, G. Muday, J. Friml, T. Beeckman, PNAS 109 (2012) 1554–1559.","apa":"Grunewald, W., De Smet, I., Lewis, D., Löfke, C., Jansen, L., Goeminne, G., … Beeckman, T. (2012). Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1121134109\">https://doi.org/10.1073/pnas.1121134109</a>","ista":"Grunewald W, De Smet I, Lewis D, Löfke C, Jansen L, Goeminne G, Vanden Bossche R, Karimi M, De Rybel B, Vanholme B, Teichmann T, Boerjan W, Van Montagu M, Gheysen G, Muday G, Friml J, Beeckman T. 2012. Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis. PNAS. 109(5), 1554–1559.","chicago":"Grunewald, Wim, Ive De Smet, Daniel Lewis, Christian Löfke, Leentje Jansen, Geert Goeminne, Robin Vanden Bossche, et al. “Transcription Factor WRKY23 Assists Auxin Distribution Patterns during Arabidopsis Root Development through Local Control on Flavonol Biosynthesis.” <i>PNAS</i>. National Academy of Sciences, 2012. <a href=\"https://doi.org/10.1073/pnas.1121134109\">https://doi.org/10.1073/pnas.1121134109</a>.","mla":"Grunewald, Wim, et al. “Transcription Factor WRKY23 Assists Auxin Distribution Patterns during Arabidopsis Root Development through Local Control on Flavonol Biosynthesis.” <i>PNAS</i>, vol. 109, no. 5, National Academy of Sciences, 2012, pp. 1554–59, doi:<a href=\"https://doi.org/10.1073/pnas.1121134109\">10.1073/pnas.1121134109</a>.","ieee":"W. Grunewald <i>et al.</i>, “Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis,” <i>PNAS</i>, vol. 109, no. 5. National Academy of Sciences, pp. 1554–1559, 2012."},"_id":"3104","volume":109,"publication":"PNAS","date_created":"2018-12-11T12:01:24Z","date_published":"2012-01-31T00:00:00Z","doi":"10.1073/pnas.1121134109","extern":1,"day":"31"},{"publist_id":"3594","year":"2012","page":"678 - 685","month":"03","publisher":"Cell Press","abstract":[{"text":"Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signaling within the cellular microenvironment. We show that genes coding for small secretory peptides, designated GOLVEN (GLV), modulate the distribution of the phytohormone auxin. The deregulation of the GLV function impairs the formation of auxin gradients and alters the reorientation of shoots and roots after a gravity stimulus. Specifically, the GLV signal modulates the trafficking dynamics of the auxin efflux carrier PIN-FORMED2 involved in root tropic responses and meristem organization. Our work links the local action of secretory peptides with phytohormone transport. Root growth factor (RGF) or GOLVEN (GLV) secreted peptides have previously been implicated in meristem regulation. Whitford et al. now show that RGF/GLV peptides induce rapid relocalization of the auxin efflux regulator PIN2, regulate auxin gradients, and modulate auxin-dependent root responses to specific stimuli.","lang":"eng"}],"date_updated":"2021-01-12T07:41:06Z","publication_status":"published","quality_controlled":0,"issue":"3","intvolume":"        22","type":"journal_article","title":"GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses","status":"public","date_created":"2018-12-11T12:01:25Z","publication":"Developmental Cell","volume":22,"_id":"3105","citation":{"chicago":"Whitford, Ryan, Ana Fernandez, Ricardo Tejos, Amparo Pérez, Jürgen Kleine Vehn, Steffen Vanneste, Andrzej Drozdzecki, et al. “GOLVEN Secretory Peptides Regulate Auxin Carrier Turnover during Plant Gravitropic Responses.” <i>Developmental Cell</i>. Cell Press, 2012. <a href=\"https://doi.org/10.1016/j.devcel.2012.02.002\">https://doi.org/10.1016/j.devcel.2012.02.002</a>.","mla":"Whitford, Ryan, et al. “GOLVEN Secretory Peptides Regulate Auxin Carrier Turnover during Plant Gravitropic Responses.” <i>Developmental Cell</i>, vol. 22, no. 3, Cell Press, 2012, pp. 678–85, doi:<a href=\"https://doi.org/10.1016/j.devcel.2012.02.002\">10.1016/j.devcel.2012.02.002</a>.","short":"R. Whitford, A. Fernandez, R. Tejos, A. Pérez, J. Kleine Vehn, S. Vanneste, A. Drozdzecki, J. Leitner, L. Abas, M. Aerts, K. Hoogewijs, P. Baster, R. De Groodt, Y. Lin, V. Storme, Y. Van De Peer, T. Beeckman, A. Madder, B. Devreese, C. Luschnig, J. Friml, P. Hilson, Developmental Cell 22 (2012) 678–685.","ama":"Whitford R, Fernandez A, Tejos R, et al. GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses. <i>Developmental Cell</i>. 2012;22(3):678-685. doi:<a href=\"https://doi.org/10.1016/j.devcel.2012.02.002\">10.1016/j.devcel.2012.02.002</a>","apa":"Whitford, R., Fernandez, A., Tejos, R., Pérez, A., Kleine Vehn, J., Vanneste, S., … Hilson, P. (2012). GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2012.02.002\">https://doi.org/10.1016/j.devcel.2012.02.002</a>","ista":"Whitford R, Fernandez A, Tejos R, Pérez A, Kleine Vehn J, Vanneste S, Drozdzecki A, Leitner J, Abas L, Aerts M, Hoogewijs K, Baster P, De Groodt R, Lin Y, Storme V, Van De Peer Y, Beeckman T, Madder A, Devreese B, Luschnig C, Friml J, Hilson P. 2012. GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses. Developmental Cell. 22(3), 678–685.","ieee":"R. Whitford <i>et al.</i>, “GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses,” <i>Developmental Cell</i>, vol. 22, no. 3. Cell Press, pp. 678–685, 2012."},"author":[{"full_name":"Whitford, Ryan","first_name":"Ryan","last_name":"Whitford"},{"full_name":"Fernandez, Ana","first_name":"Ana","last_name":"Fernandez"},{"full_name":"Tejos, Ricardo","first_name":"Ricardo","last_name":"Tejos"},{"last_name":"Pérez","first_name":"Amparo","full_name":"Pérez, Amparo Cuéllar"},{"last_name":"Kleine Vehn","first_name":"Jürgen","full_name":"Kleine-Vehn, Jürgen"},{"full_name":"Vanneste, Steffen","first_name":"Steffen","last_name":"Vanneste"},{"full_name":"Drozdzecki, Andrzej","last_name":"Drozdzecki","first_name":"Andrzej"},{"first_name":"Johannes","last_name":"Leitner","full_name":"Leitner, Johannes"},{"full_name":"Abas, Lindy","first_name":"Lindy","last_name":"Abas"},{"full_name":"Aerts, Maarten","last_name":"Aerts","first_name":"Maarten"},{"full_name":"Hoogewijs, Kurt","first_name":"Kurt","last_name":"Hoogewijs"},{"last_name":"Baster","first_name":"Pawel","full_name":"Pawel Baster","id":"3028BD74-F248-11E8-B48F-1D18A9856A87"},{"last_name":"De Groodt","first_name":"Ruth","full_name":"De Groodt, Ruth"},{"full_name":"Lin, Yao-Cheng","last_name":"Lin","first_name":"Yao"},{"first_name":"Véronique","last_name":"Storme","full_name":"Storme, Véronique"},{"first_name":"Yves","last_name":"Van De Peer","full_name":"Van de Peer, Yves"},{"last_name":"Beeckman","first_name":"Tom","full_name":"Beeckman, Tom"},{"full_name":"Madder, Annemieke","first_name":"Annemieke","last_name":"Madder"},{"first_name":"Bart","last_name":"Devreese","full_name":"Devreese, Bart"},{"first_name":"Christian","last_name":"Luschnig","full_name":"Luschnig, Christian"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jirí","orcid":"0000-0002-8302-7596","full_name":"Jirí Friml"},{"full_name":"Hilson, Pierre","last_name":"Hilson","first_name":"Pierre"}],"day":"13","extern":1,"doi":"10.1016/j.devcel.2012.02.002","date_published":"2012-03-13T00:00:00Z"},{"issue":"4","quality_controlled":0,"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"title":"ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis","type":"journal_article","intvolume":"        10","year":"2012","publist_id":"3593","publication_status":"published","abstract":[{"text":"Cell polarization via asymmetrical distribution of structures or molecules is essential for diverse cellular functions and development of organisms, but how polarity is developmentally controlled has been poorly understood. In plants, the asymmetrical distribution of the PIN-FORMED (PIN) proteins involved in the cellular efflux of the quintessential phytohormone auxin plays a central role in developmental patterning, morphogenesis, and differential growth. Recently we showed that auxin promotes cell interdigitation by activating the Rho family ROP GTPases in leaf epidermal pavement cells. Here we found that auxin activation of the ROP2 signaling pathway regulates the asymmetric distribution of PIN1 by inhibiting its endocytosis. ROP2 inhibits PIN1 endocytosis via the accumulation of cortical actin microfilaments induced by the ROP2 effector protein RIC4. Our findings suggest a link between the developmental auxin signal and polar PIN1 distribution via Rho-dependent cytoskeletal reorganization and reveal the conservation of a design principle for cell polarization that is based on Rho GTPase-mediated inhibition of endocytosis.","lang":"eng"}],"date_updated":"2021-01-12T07:41:06Z","publisher":"Public Library of Science","month":"04","extern":1,"day":"01","date_published":"2012-04-01T00:00:00Z","doi":"10.1371/journal.pbio.1001299","publication":"PLoS Biology","volume":10,"date_created":"2018-12-11T12:01:25Z","author":[{"last_name":"Nagawa","first_name":"Shingo","full_name":"Nagawa, Shingo"},{"full_name":"Xu, Tongda","first_name":"Tongda","last_name":"Xu"},{"last_name":"Lin","first_name":"Deshu","full_name":"Lin, Deshu"},{"full_name":"Dhonukshe, Pankaj","first_name":"Pankaj","last_name":"Dhonukshe"},{"last_name":"Zhang","first_name":"Xingxing","full_name":"Zhang, Xingxing"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Jirí Friml"},{"first_name":"Ben","last_name":"Scheres","full_name":"Scheres, Ben"},{"full_name":"Fu, Ying","last_name":"Fu","first_name":"Ying"},{"last_name":"Yang","first_name":"Zhenbiao","full_name":"Yang, Zhenbiao"}],"citation":{"ieee":"S. Nagawa <i>et al.</i>, “ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis,” <i>PLoS Biology</i>, vol. 10, no. 4. Public Library of Science, 2012.","short":"S. Nagawa, T. Xu, D. Lin, P. Dhonukshe, X. Zhang, J. Friml, B. Scheres, Y. Fu, Z. Yang, PLoS Biology 10 (2012).","ama":"Nagawa S, Xu T, Lin D, et al. ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis. <i>PLoS Biology</i>. 2012;10(4). doi:<a href=\"https://doi.org/10.1371/journal.pbio.1001299\">10.1371/journal.pbio.1001299</a>","apa":"Nagawa, S., Xu, T., Lin, D., Dhonukshe, P., Zhang, X., Friml, J., … Yang, Z. (2012). ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis. <i>PLoS Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.1001299\">https://doi.org/10.1371/journal.pbio.1001299</a>","ista":"Nagawa S, Xu T, Lin D, Dhonukshe P, Zhang X, Friml J, Scheres B, Fu Y, Yang Z. 2012. ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis. PLoS Biology. 10(4).","chicago":"Nagawa, Shingo, Tongda Xu, Deshu Lin, Pankaj Dhonukshe, Xingxing Zhang, Jiří Friml, Ben Scheres, Ying Fu, and Zhenbiao Yang. “ROP GTPase-Dependent Actin Microfilaments Promote PIN1 Polarization by Localized Inhibition of Clathrin-Dependent Endocytosis.” <i>PLoS Biology</i>. Public Library of Science, 2012. <a href=\"https://doi.org/10.1371/journal.pbio.1001299\">https://doi.org/10.1371/journal.pbio.1001299</a>.","mla":"Nagawa, Shingo, et al. “ROP GTPase-Dependent Actin Microfilaments Promote PIN1 Polarization by Localized Inhibition of Clathrin-Dependent Endocytosis.” <i>PLoS Biology</i>, vol. 10, no. 4, Public Library of Science, 2012, doi:<a href=\"https://doi.org/10.1371/journal.pbio.1001299\">10.1371/journal.pbio.1001299</a>."},"_id":"3106"},{"citation":{"ieee":"S. Vanneste and J. Friml, <i>Plant signaling: Deconstructing auxin sensing</i>, vol. 8, no. 5. Nature Publishing Group, 2012, pp. 415–416.","ama":"Vanneste S, Friml J. <i>Plant Signaling: Deconstructing Auxin Sensing</i>. Vol 8. Nature Publishing Group; 2012:415-416. doi:<a href=\"https://doi.org/10.1038/nchembio.943\">10.1038/nchembio.943</a>","short":"S. Vanneste, J. Friml, Plant Signaling: Deconstructing Auxin Sensing, Nature Publishing Group, 2012.","ista":"Vanneste S, Friml J. 2012. Plant signaling: Deconstructing auxin sensing, Nature Publishing Group,p.","apa":"Vanneste, S., &#38; Friml, J. (2012). <i>Plant signaling: Deconstructing auxin sensing</i>. <i>Nature Chemical Biology</i> (Vol. 8, pp. 415–416). Nature Publishing Group. <a href=\"https://doi.org/10.1038/nchembio.943\">https://doi.org/10.1038/nchembio.943</a>","chicago":"Vanneste, Steffen, and Jiří Friml. <i>Plant Signaling: Deconstructing Auxin Sensing</i>. <i>Nature Chemical Biology</i>. Vol. 8. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nchembio.943\">https://doi.org/10.1038/nchembio.943</a>.","mla":"Vanneste, Steffen, and Jiří Friml. “Plant Signaling: Deconstructing Auxin Sensing.” <i>Nature Chemical Biology</i>, vol. 8, no. 5, Nature Publishing Group, 2012, pp. 415–16, doi:<a href=\"https://doi.org/10.1038/nchembio.943\">10.1038/nchembio.943</a>."},"_id":"3107","author":[{"full_name":"Vanneste, Steffen","first_name":"Steffen","last_name":"Vanneste"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","last_name":"Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"publication":"Nature Chemical Biology","volume":8,"date_created":"2018-12-11T12:01:26Z","language":[{"iso":"eng"}],"date_published":"2012-05-01T00:00:00Z","doi":"10.1038/nchembio.943","extern":"1","day":"01","publisher":"Nature Publishing Group","month":"05","publication_status":"published","date_updated":"2021-01-12T07:41:06Z","page":"415 - 416","year":"2012","publist_id":"3592","intvolume":"         8","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","title":"Plant signaling: Deconstructing auxin sensing","status":"public","type":"other_academic_publication","oa_version":"None","issue":"5","quality_controlled":"1"},{"type":"journal_article","title":"A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants","status":"public","intvolume":"       485","issue":"7396","quality_controlled":0,"date_updated":"2021-01-12T07:41:07Z","abstract":[{"text":"The phytohormone auxin acts as a prominent signal, providing, by its local accumulation or depletion in selected cells, a spatial and temporal reference for changes in the developmental program. The distribution of auxin depends on both auxin metabolism (biosynthesis, conjugation and degradation) and cellular auxin transport. We identified in silico a novel putative auxin transport facilitator family, called PIN-LIKES (PILS). Here we illustrate that PILS proteins are required for auxin-dependent regulation of plant growth by determining the cellular sensitivity to auxin. PILS proteins regulate intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signalling. PILS activity affects the level of endogenous auxin indole-3-acetic acid (IAA), presumably via intracellular accumulation and metabolism. Our findings reveal that the transport machinery to compartmentalize auxin within the cell is of an unexpected molecular complexity and demonstrate this compartmentalization to be functionally important for a number of developmental processes.","lang":"eng"}],"publication_status":"published","month":"05","publisher":"Nature Publishing Group","publist_id":"3591","year":"2012","page":"119 - 122","doi":"10.1038/nature11001","date_published":"2012-05-03T00:00:00Z","day":"03","extern":1,"author":[{"first_name":"Elke","last_name":"Barbez","full_name":"Barbez, Elke"},{"first_name":"Martin","last_name":"Kubeš","full_name":"Kubeš, Martin"},{"full_name":"Rolčík, Jakub","first_name":"Jakub","last_name":"Rolčík"},{"full_name":"Béziat, Chloe","last_name":"Béziat","first_name":"Chloe"},{"first_name":"Aleš","last_name":"Pěnčík","full_name":"Pěnčík, Aleš"},{"last_name":"Wang","first_name":"Bangjun","full_name":"Wang, Bangjun"},{"last_name":"Rosquete","first_name":"Michel","full_name":"Rosquete, Michel Ruiz"},{"last_name":"Zhu","first_name":"Jinsheng","full_name":"Zhu, Jinsheng"},{"last_name":"Dobrev","first_name":"Petre","full_name":"Dobrev, Petre I"},{"full_name":"Lee, Yuree","last_name":"Lee","first_name":"Yuree"},{"full_name":"Zašímalová, Eva","last_name":"Zašímalová","first_name":"Eva"},{"full_name":"Petrášek, Jan","last_name":"Petrášek","first_name":"Jan"},{"full_name":"Geisler, Markus","first_name":"Markus","last_name":"Geisler"},{"full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jürgen","last_name":"Kleine Vehn","full_name":"Kleine-Vehn, Jürgen"}],"_id":"3108","citation":{"ieee":"E. Barbez <i>et al.</i>, “A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants,” <i>Nature</i>, vol. 485, no. 7396. Nature Publishing Group, pp. 119–122, 2012.","mla":"Barbez, Elke, et al. “A Novel Putative Auxin Carrier Family Regulates Intracellular Auxin Homeostasis in Plants.” <i>Nature</i>, vol. 485, no. 7396, Nature Publishing Group, 2012, pp. 119–22, doi:<a href=\"https://doi.org/10.1038/nature11001\">10.1038/nature11001</a>.","chicago":"Barbez, Elke, Martin Kubeš, Jakub Rolčík, Chloe Béziat, Aleš Pěnčík, Bangjun Wang, Michel Rosquete, et al. “A Novel Putative Auxin Carrier Family Regulates Intracellular Auxin Homeostasis in Plants.” <i>Nature</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nature11001\">https://doi.org/10.1038/nature11001</a>.","ista":"Barbez E, Kubeš M, Rolčík J, Béziat C, Pěnčík A, Wang B, Rosquete M, Zhu J, Dobrev P, Lee Y, Zašímalová E, Petrášek J, Geisler M, Friml J, Kleine Vehn J. 2012. A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants. Nature. 485(7396), 119–122.","apa":"Barbez, E., Kubeš, M., Rolčík, J., Béziat, C., Pěnčík, A., Wang, B., … Kleine Vehn, J. (2012). A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature11001\">https://doi.org/10.1038/nature11001</a>","ama":"Barbez E, Kubeš M, Rolčík J, et al. A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants. <i>Nature</i>. 2012;485(7396):119-122. doi:<a href=\"https://doi.org/10.1038/nature11001\">10.1038/nature11001</a>","short":"E. Barbez, M. Kubeš, J. Rolčík, C. Béziat, A. Pěnčík, B. Wang, M. Rosquete, J. Zhu, P. Dobrev, Y. Lee, E. Zašímalová, J. Petrášek, M. Geisler, J. Friml, J. Kleine Vehn, Nature 485 (2012) 119–122."},"date_created":"2018-12-11T12:01:26Z","volume":485,"publication":"Nature"},{"doi":"10.1038/nchembio.958","date_published":"2012-06-01T00:00:00Z","day":"01","extern":1,"author":[{"full_name":"Irani, Niloufer G","first_name":"Niloufer","last_name":"Irani"},{"full_name":"Di Rubbo, Simone","last_name":"Di Rubbo","first_name":"Simone"},{"full_name":"Mylle, Evelien","first_name":"Evelien","last_name":"Mylle"},{"last_name":"Van Den Begin","first_name":"Jos","full_name":"Van Den Begin, Jos"},{"full_name":"Schneider-Pizoń, Joanna","first_name":"Joanna","last_name":"Schneider Pizoń"},{"last_name":"Hniliková","first_name":"Jaroslava","full_name":"Hniliková, Jaroslava"},{"full_name":"Šíša, Miroslav","last_name":"Šíša","first_name":"Miroslav"},{"first_name":"Dieter","last_name":"Buyst","full_name":"Buyst, Dieter"},{"full_name":"Vilarrasa-Blasi, Josep","first_name":"Josep","last_name":"Vilarrasa Blasi"},{"first_name":"Anna","last_name":"Szatmári","full_name":"Szatmári, Anna-Maria"},{"full_name":"Van Damme, Daniël","last_name":"Van Damme","first_name":"Daniël"},{"first_name":"Kiril","last_name":"Mishev","full_name":"Mishev, Kiril"},{"full_name":"Codreanu, Mirela-Corina","first_name":"Mirela","last_name":"Codreanu"},{"first_name":"Ladislav","last_name":"Kohout","full_name":"Kohout, Ladislav"},{"full_name":"Strnad, Miroslav","last_name":"Strnad","first_name":"Miroslav"},{"full_name":"Caño-Delgado, Ana I","first_name":"Ana","last_name":"Caño Delgado"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jirí","orcid":"0000-0002-8302-7596","full_name":"Jirí Friml"},{"full_name":"Madder, Annemieke","first_name":"Annemieke","last_name":"Madder"},{"first_name":"Eugenia","last_name":"Russinova","full_name":"Russinova, Eugenia"}],"_id":"3109","citation":{"chicago":"Irani, Niloufer, Simone Di Rubbo, Evelien Mylle, Jos Van Den Begin, Joanna Schneider Pizoń, Jaroslava Hniliková, Miroslav Šíša, et al. “Fluorescent Castasterone Reveals BRI1 Signaling from the Plasma Membrane.” <i>Nature Chemical Biology</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nchembio.958\">https://doi.org/10.1038/nchembio.958</a>.","mla":"Irani, Niloufer, et al. “Fluorescent Castasterone Reveals BRI1 Signaling from the Plasma Membrane.” <i>Nature Chemical Biology</i>, vol. 8, no. 6, Nature Publishing Group, 2012, pp. 583–89, doi:<a href=\"https://doi.org/10.1038/nchembio.958\">10.1038/nchembio.958</a>.","ama":"Irani N, Di Rubbo S, Mylle E, et al. Fluorescent castasterone reveals BRI1 signaling from the plasma membrane. <i>Nature Chemical Biology</i>. 2012;8(6):583-589. doi:<a href=\"https://doi.org/10.1038/nchembio.958\">10.1038/nchembio.958</a>","short":"N. Irani, S. Di Rubbo, E. Mylle, J. Van Den Begin, J. Schneider Pizoń, J. Hniliková, M. Šíša, D. Buyst, J. Vilarrasa Blasi, A. Szatmári, D. Van Damme, K. Mishev, M. Codreanu, L. Kohout, M. Strnad, A. Caño Delgado, J. Friml, A. Madder, E. Russinova, Nature Chemical Biology 8 (2012) 583–589.","apa":"Irani, N., Di Rubbo, S., Mylle, E., Van Den Begin, J., Schneider Pizoń, J., Hniliková, J., … Russinova, E. (2012). Fluorescent castasterone reveals BRI1 signaling from the plasma membrane. <i>Nature Chemical Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nchembio.958\">https://doi.org/10.1038/nchembio.958</a>","ista":"Irani N, Di Rubbo S, Mylle E, Van Den Begin J, Schneider Pizoń J, Hniliková J, Šíša M, Buyst D, Vilarrasa Blasi J, Szatmári A, Van Damme D, Mishev K, Codreanu M, Kohout L, Strnad M, Caño Delgado A, Friml J, Madder A, Russinova E. 2012. Fluorescent castasterone reveals BRI1 signaling from the plasma membrane. Nature Chemical Biology. 8(6), 583–589.","ieee":"N. Irani <i>et al.</i>, “Fluorescent castasterone reveals BRI1 signaling from the plasma membrane,” <i>Nature Chemical Biology</i>, vol. 8, no. 6. Nature Publishing Group, pp. 583–589, 2012."},"date_created":"2018-12-11T12:01:26Z","publication":"Nature Chemical Biology","volume":8,"type":"journal_article","title":"Fluorescent castasterone reveals BRI1 signaling from the plasma membrane","status":"public","intvolume":"         8","issue":"6","quality_controlled":0,"abstract":[{"lang":"eng","text":"Receptor-mediated endocytosis is an integral part of signal transduction as it mediates signal attenuation and provides spatial and temporal dimensions to signaling events. One of the best-studied leucine-rich repeat receptor-like kinases in plants, BRASSINOSTEROID INSENSITIVE 1 (BRI1), perceives its ligand, the brassinosteroid (BR) hormone, at the cell surface and is constitutively endocytosed. However, the importance of endocytosis for BR signaling remains unclear. Here we developed a bioactive, fluorescent BR analog, Alexa Fluor 647-castasterone (AFCS), and visualized the endocytosis of BRI1-AFCS complexes in living Arabidopsis thaliana cells. Impairment of endocytosis dependent on clathrin and the guanine nucleotide exchange factor for ARF GTPases (ARF-GEF) GNOM enhanced BR signaling by retaining active BRI1-ligand complexes at the plasma membrane. Increasing the trans-Golgi network/early endosome pool of BRI1-BR complexes did not affect BR signaling. Our findings provide what is to our knowledge the first visualization of receptor-ligand complexes in plants and reveal clathrin-and ARF-GEF-dependent endocytic regulation of BR signaling from the plasma membrane."}],"date_updated":"2021-01-12T07:41:07Z","publication_status":"published","month":"06","publisher":"Nature Publishing Group","publist_id":"3590","page":"583 - 589","year":"2012"},{"date_created":"2018-12-11T12:01:27Z","volume":24,"publication":"Plant Cell","author":[{"last_name":"Dai","first_name":"Mingqiu","full_name":"Dai, Mingqiu"},{"full_name":"Zhang, Chen","last_name":"Zhang","first_name":"Chen"},{"id":"4AE5C486-F248-11E8-B48F-1D18A9856A87","last_name":"Kania","first_name":"Urszula","full_name":"Urszula Kania"},{"full_name":"Chen, Fang","last_name":"Chen","first_name":"Fang"},{"first_name":"Qin","last_name":"Xue","full_name":"Xue, Qin"},{"full_name":"McCray, Tyra","last_name":"Mccray","first_name":"Tyra"},{"last_name":"Li","first_name":"Gang","full_name":"Li, Gang"},{"full_name":"Qin, Genji","first_name":"Genji","last_name":"Qin"},{"last_name":"Wakeley","first_name":"Michelle","full_name":"Wakeley, Michelle"},{"full_name":"Terzaghi, William","first_name":"William","last_name":"Terzaghi"},{"full_name":"Wan, Jianmin","first_name":"Jianmin","last_name":"Wan"},{"last_name":"Zhao","first_name":"Yunde","full_name":"Zhao, Yunde"},{"full_name":"Xu, Jian","last_name":"Xu","first_name":"Jian"},{"last_name":"Friml","first_name":"Jirí","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Deng, Xing W","last_name":"Deng","first_name":"Xing"},{"last_name":"Wang","first_name":"Haiyang","full_name":"Wang, Haiyang"}],"_id":"3110","citation":{"mla":"Dai, Mingqiu, et al. “A PP6 Type Phosphatase Holoenzyme Directly Regulates PIN Phosphorylation and Auxin Efflux in Arabidopsis.” <i>Plant Cell</i>, vol. 24, no. 6, American Society of Plant Biologists, 2012, pp. 2497–514, doi:<a href=\"https://doi.org/10.1105/tpc.112.098905\">10.1105/tpc.112.098905</a>.","chicago":"Dai, Mingqiu, Chen Zhang, Urszula Kania, Fang Chen, Qin Xue, Tyra Mccray, Gang Li, et al. “A PP6 Type Phosphatase Holoenzyme Directly Regulates PIN Phosphorylation and Auxin Efflux in Arabidopsis.” <i>Plant Cell</i>. American Society of Plant Biologists, 2012. <a href=\"https://doi.org/10.1105/tpc.112.098905\">https://doi.org/10.1105/tpc.112.098905</a>.","ista":"Dai M, Zhang C, Kania U, Chen F, Xue Q, Mccray T, Li G, Qin G, Wakeley M, Terzaghi W, Wan J, Zhao Y, Xu J, Friml J, Deng X, Wang H. 2012. A PP6 type phosphatase holoenzyme directly regulates PIN phosphorylation and auxin efflux in Arabidopsis. Plant Cell. 24(6), 2497–2514.","apa":"Dai, M., Zhang, C., Kania, U., Chen, F., Xue, Q., Mccray, T., … Wang, H. (2012). A PP6 type phosphatase holoenzyme directly regulates PIN phosphorylation and auxin efflux in Arabidopsis. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.112.098905\">https://doi.org/10.1105/tpc.112.098905</a>","ama":"Dai M, Zhang C, Kania U, et al. A PP6 type phosphatase holoenzyme directly regulates PIN phosphorylation and auxin efflux in Arabidopsis. <i>Plant Cell</i>. 2012;24(6):2497-2514. doi:<a href=\"https://doi.org/10.1105/tpc.112.098905\">10.1105/tpc.112.098905</a>","short":"M. Dai, C. Zhang, U. Kania, F. Chen, Q. Xue, T. Mccray, G. Li, G. Qin, M. Wakeley, W. Terzaghi, J. Wan, Y. Zhao, J. Xu, J. Friml, X. Deng, H. Wang, Plant Cell 24 (2012) 2497–2514.","ieee":"M. Dai <i>et al.</i>, “A PP6 type phosphatase holoenzyme directly regulates PIN phosphorylation and auxin efflux in Arabidopsis,” <i>Plant Cell</i>, vol. 24, no. 6. American Society of Plant Biologists, pp. 2497–2514, 2012."},"day":"01","extern":1,"doi":"10.1105/tpc.112.098905","date_published":"2012-06-01T00:00:00Z","publist_id":"3589","year":"2012","page":"2497 - 2514","date_updated":"2021-01-12T07:41:08Z","abstract":[{"lang":"eng","text":"The directional transport of the phytohormone auxin depends on the phosphorylation status and polar localization of PIN-FORMED (PIN) auxin efflux proteins. While PINIOD (PID) kinase is directly involved in the phosphorylation of PIN proteins, the phosphatase holoenzyme complexes that dephosphorylate PIN proteins remain elusive. Here, we demonstrate that mutations simultaneously disrupting the function of Arabidopsis thaliana FyPP1 (for Phytochrome-associated serine/threonine protein phosphatase1) and FyPP3, two homologous genes encoding the catalytic subunits of protein phosphatase6 (PP6), cause elevated accumulation of phosphorylated PIN proteins, correlating with a basal-to-apical shift in subcellular PIN localization. The changes in PIN polarity result in increased root basipetal auxin transport and severe defects, including shorter roots, fewer lateral roots, defective columella cells, root meristem collapse, abnormal cotyledons (small, cup-shaped, or fused cotyledons), and altered leaf venation. Our molecular, biochemical, and genetic data support the notion that FyPP1/3, SAL (for SAPS DOMAIN-LIKE), and PP2AA proteins (RCN1 [for ROOTS CURL IN NAPHTHYLPHTHALAMIC ACID1] or PP2AA1, PP2AA2, and PP2AA3) physically interact to form a novel PP6-type heterotrimeric holoenzyme complex. We also show that FyPP1/3, SAL, and PP2AA interact with a subset of PIN proteins and that for SAL the strength of the interaction depends on the PIN phosphorylation status. Thus, an Arabidopsis PP6-type phosphatase holoenzyme acts antagonistically with PID to direct auxin transport polarity and plant development by directly regulating PIN phosphorylation. "}],"publication_status":"published","month":"06","publisher":"American Society of Plant Biologists","quality_controlled":0,"issue":"6","type":"journal_article","title":"A PP6 type phosphatase holoenzyme directly regulates PIN phosphorylation and auxin efflux in Arabidopsis","status":"public","intvolume":"        24"},{"date_created":"2018-12-11T12:01:27Z","publication":"Current Biology","volume":22,"_id":"3111","citation":{"ieee":"D. Lin <i>et al.</i>, “A ROP GTPase dependent auxin signaling pathway regulates the subcellular distribution of PIN2 in Arabidopsis roots,” <i>Current Biology</i>, vol. 22, no. 14. Cell Press, pp. 1319–1325, 2012.","short":"D. Lin, S. Nagawa, J. Chen, L. Cao, X. Chen, T. Xu, H. Li, P. Dhonukshe, C. Yamamuro, J. Friml, B. Scheres, Y. Fu, Z. Yang, Current Biology 22 (2012) 1319–1325.","ama":"Lin D, Nagawa S, Chen J, et al. A ROP GTPase dependent auxin signaling pathway regulates the subcellular distribution of PIN2 in Arabidopsis roots. <i>Current Biology</i>. 2012;22(14):1319-1325. doi:<a href=\"https://doi.org/10.1016/j.cub.2012.05.019\">10.1016/j.cub.2012.05.019</a>","ista":"Lin D, Nagawa S, Chen J, Cao L, Chen X, Xu T, Li H, Dhonukshe P, Yamamuro C, Friml J, Scheres B, Fu Y, Yang Z. 2012. A ROP GTPase dependent auxin signaling pathway regulates the subcellular distribution of PIN2 in Arabidopsis roots. Current Biology. 22(14), 1319–1325.","apa":"Lin, D., Nagawa, S., Chen, J., Cao, L., Chen, X., Xu, T., … Yang, Z. (2012). A ROP GTPase dependent auxin signaling pathway regulates the subcellular distribution of PIN2 in Arabidopsis roots. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2012.05.019\">https://doi.org/10.1016/j.cub.2012.05.019</a>","chicago":"Lin, Deshu, Shingo Nagawa, Jisheng Chen, Lingyan Cao, Xu Chen, Tongda Xu, Hongjiang Li, et al. “A ROP GTPase Dependent Auxin Signaling Pathway Regulates the Subcellular Distribution of PIN2 in Arabidopsis Roots.” <i>Current Biology</i>. Cell Press, 2012. <a href=\"https://doi.org/10.1016/j.cub.2012.05.019\">https://doi.org/10.1016/j.cub.2012.05.019</a>.","mla":"Lin, Deshu, et al. “A ROP GTPase Dependent Auxin Signaling Pathway Regulates the Subcellular Distribution of PIN2 in Arabidopsis Roots.” <i>Current Biology</i>, vol. 22, no. 14, Cell Press, 2012, pp. 1319–25, doi:<a href=\"https://doi.org/10.1016/j.cub.2012.05.019\">10.1016/j.cub.2012.05.019</a>."},"author":[{"full_name":"Lin, Deshu","first_name":"Deshu","last_name":"Lin"},{"full_name":"Nagawa, Shingo","first_name":"Shingo","last_name":"Nagawa"},{"last_name":"Chen","first_name":"Jisheng","full_name":"Chen, Jisheng"},{"full_name":"Cao, Lingyan","last_name":"Cao","first_name":"Lingyan"},{"full_name":"Xu Chen","first_name":"Xu","last_name":"Chen","id":"4E5ADCAA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Tongda","last_name":"Xu","full_name":"Xu, Tongda"},{"full_name":"Hongjiang Li","orcid":"0000-0001-5039-9660","first_name":"Hongjiang","last_name":"Li","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Pankaj","last_name":"Dhonukshe","full_name":"Dhonukshe, Pankaj"},{"full_name":"Yamamuro, Chizuko","first_name":"Chizuko","last_name":"Yamamuro"},{"full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Scheres, Ben","last_name":"Scheres","first_name":"Ben"},{"full_name":"Fu, Ying","first_name":"Ying","last_name":"Fu"},{"first_name":"Zhenbiao","last_name":"Yang","full_name":"Yang, Zhenbiao"}],"day":"24","extern":1,"doi":"10.1016/j.cub.2012.05.019","date_published":"2012-07-24T00:00:00Z","publist_id":"3588","page":"1319 - 1325","year":"2012","month":"07","publisher":"Cell Press","date_updated":"2021-01-12T07:41:08Z","abstract":[{"lang":"eng","text":"PIN-FORMED (PIN) protein-mediated auxin polar transport is critically important for development, pattern formation, and morphogenesis in plants. Auxin has been implicated in the regulation of polar auxin transport by inhibiting PIN endocytosis [1, 2], but how auxin regulates this process is poorly understood. Our genetic screen identified the Arabidopsis SPIKE1 (SPK1) gene whose loss-of-function mutations increased lateral root density and retarded gravitropic responses, as do pin2 knockout mutations [3]. SPK1 belongs to the conserved DHR2-Dock family of Rho guanine nucleotide exchange factors [4-6]. The spk1 mutations induced PIN2 internalization that was not suppressed by auxin, as did the loss-of-function mutations for Rho-like GTPase from Plants 6 (ROP6)-GTPase or its effector RIC1. Furthermore, SPK1 was required for auxin induction of ROP6 activation. Our results have established a Rho GTPase-based auxin signaling pathway that maintains PIN2 polar distribution to the plasma membrane via inhibition of its internalization in Arabidopsis roots. Our findings provide new insights into signaling mechanisms that underlie the regulation of the dynamic trafficking of PINs required for long-distance auxin transport and that link auxin signaling to PIN-mediated pattern formation and morphogenesis."}],"publication_status":"published","issue":"14","quality_controlled":0,"intvolume":"        22","type":"journal_article","status":"public","title":"A ROP GTPase dependent auxin signaling pathway regulates the subcellular distribution of PIN2 in Arabidopsis roots"},{"publisher":"Cell Press","month":"07","publication_status":"published","date_updated":"2021-01-12T07:41:08Z","abstract":[{"lang":"eng","text":"The dynamic spatial and temporal distribution of the crucial plant signaling molecule auxin is achieved by feedback coordination of auxin signaling and intercellular auxin transport pathways [1, 2]. Developmental roles of auxin have been attributed predominantly to its effect on transcription; however, an alternative pathway involving AUXIN BINDING PROTEIN1 (ABP1) has been proposed to regulate clathrin-mediated endocytosis in roots and Rho-like GTPase (ROP)-dependent pavement cell interdigitation in leaves [3, 4]. In this study, we show that ROP6 and its downstream effector RIC1 regulate clathrin association with the plasma membrane for clathrin-mediated endocytosis, as well as for its feedback regulation by auxin. Genetic analysis revealed that ROP6/RIC1 acts downstream of ABP1 to regulate endocytosis. This signaling circuit is also involved in the feedback regulation of PIN-FORMED 1 (PIN1) and PIN2 auxin transporters activity (via its constitutive endocytosis) and corresponding auxin transport-mediated processes, including root gravitropism and leave vascular tissue patterning. Our findings suggest that the signaling module auxin-ABP1-ROP6/RIC1-clathrin-PIN1/PIN2 is a shared component of the feedback regulation of auxin transport during both root and aerial development."}],"page":"1326 - 1332","year":"2012","publist_id":"3587","intvolume":"        22","title":"ABP1 and ROP6 GTPase signaling regulate clathrin mediated endocytosis in Arabidopsis roots","status":"public","type":"journal_article","quality_controlled":0,"issue":"14","citation":{"ieee":"X. Chen <i>et al.</i>, “ABP1 and ROP6 GTPase signaling regulate clathrin mediated endocytosis in Arabidopsis roots,” <i>Current Biology</i>, vol. 22, no. 14. Cell Press, pp. 1326–1332, 2012.","chicago":"Chen, Xu, Satoshi Naramoto, Stéphanie Robert, Ricardo Tejos, Christian Löfke, Deshu Lin, Zhenbiao Yang, and Jiří Friml. “ABP1 and ROP6 GTPase Signaling Regulate Clathrin Mediated Endocytosis in Arabidopsis Roots.” <i>Current Biology</i>. Cell Press, 2012. <a href=\"https://doi.org/10.1016/j.cub.2012.05.020\">https://doi.org/10.1016/j.cub.2012.05.020</a>.","mla":"Chen, Xu, et al. “ABP1 and ROP6 GTPase Signaling Regulate Clathrin Mediated Endocytosis in Arabidopsis Roots.” <i>Current Biology</i>, vol. 22, no. 14, Cell Press, 2012, pp. 1326–32, doi:<a href=\"https://doi.org/10.1016/j.cub.2012.05.020\">10.1016/j.cub.2012.05.020</a>.","ama":"Chen X, Naramoto S, Robert S, et al. ABP1 and ROP6 GTPase signaling regulate clathrin mediated endocytosis in Arabidopsis roots. <i>Current Biology</i>. 2012;22(14):1326-1332. doi:<a href=\"https://doi.org/10.1016/j.cub.2012.05.020\">10.1016/j.cub.2012.05.020</a>","short":"X. Chen, S. Naramoto, S. Robert, R. Tejos, C. Löfke, D. Lin, Z. Yang, J. Friml, Current Biology 22 (2012) 1326–1332.","apa":"Chen, X., Naramoto, S., Robert, S., Tejos, R., Löfke, C., Lin, D., … Friml, J. (2012). ABP1 and ROP6 GTPase signaling regulate clathrin mediated endocytosis in Arabidopsis roots. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2012.05.020\">https://doi.org/10.1016/j.cub.2012.05.020</a>","ista":"Chen X, Naramoto S, Robert S, Tejos R, Löfke C, Lin D, Yang Z, Friml J. 2012. ABP1 and ROP6 GTPase signaling regulate clathrin mediated endocytosis in Arabidopsis roots. Current Biology. 22(14), 1326–1332."},"_id":"3112","author":[{"id":"4E5ADCAA-F248-11E8-B48F-1D18A9856A87","first_name":"Xu","last_name":"Chen","full_name":"Xu Chen"},{"last_name":"Naramoto","first_name":"Satoshi","full_name":"Naramoto, Satoshi"},{"full_name":"Robert, Stéphanie","last_name":"Robert","first_name":"Stéphanie"},{"last_name":"Tejos","first_name":"Ricardo","full_name":"Tejos, Ricardo"},{"last_name":"Löfke","first_name":"Christian","full_name":"Löfke, Christian"},{"last_name":"Lin","first_name":"Deshu","full_name":"Lin, Deshu"},{"last_name":"Yang","first_name":"Zhenbiao","full_name":"Yang, Zhenbiao"},{"full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"volume":22,"publication":"Current Biology","date_created":"2018-12-11T12:01:27Z","date_published":"2012-07-24T00:00:00Z","doi":"10.1016/j.cub.2012.05.020","extern":1,"day":"24"},{"citation":{"apa":"Martinière, A., Lavagi, I., Nageswaran, G., Rolfe, D., Maneta Peyret, L., Luu, D., … Runions, J. (2012). Cell wall constrains lateral diffusion of plant plasma membrane proteins. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1202040109\">https://doi.org/10.1073/pnas.1202040109</a>","ista":"Martinière A, Lavagi I, Nageswaran G, Rolfe D, Maneta Peyret L, Luu D, Botchway S, Webb S, Mongrand S, Maurel C, Martin Fernandez M, Kleine Vehn J, Friml J, Moreau P, Runions J. 2012. Cell wall constrains lateral diffusion of plant plasma membrane proteins. PNAS. 109(31), 12805–12810.","ama":"Martinière A, Lavagi I, Nageswaran G, et al. Cell wall constrains lateral diffusion of plant plasma membrane proteins. <i>PNAS</i>. 2012;109(31):12805-12810. doi:<a href=\"https://doi.org/10.1073/pnas.1202040109\">10.1073/pnas.1202040109</a>","short":"A. Martinière, I. Lavagi, G. Nageswaran, D. Rolfe, L. Maneta Peyret, D. Luu, S. Botchway, S. Webb, S. Mongrand, C. Maurel, M. Martin Fernandez, J. Kleine Vehn, J. Friml, P. Moreau, J. Runions, PNAS 109 (2012) 12805–12810.","mla":"Martinière, Alexandre, et al. “Cell Wall Constrains Lateral Diffusion of Plant Plasma Membrane Proteins.” <i>PNAS</i>, vol. 109, no. 31, National Academy of Sciences, 2012, pp. 12805–10, doi:<a href=\"https://doi.org/10.1073/pnas.1202040109\">10.1073/pnas.1202040109</a>.","chicago":"Martinière, Alexandre, Irene Lavagi, Gayathri Nageswaran, Daniel Rolfe, Lilly Maneta Peyret, Doan Luu, Stanley Botchway, et al. “Cell Wall Constrains Lateral Diffusion of Plant Plasma Membrane Proteins.” <i>PNAS</i>. National Academy of Sciences, 2012. <a href=\"https://doi.org/10.1073/pnas.1202040109\">https://doi.org/10.1073/pnas.1202040109</a>.","ieee":"A. Martinière <i>et al.</i>, “Cell wall constrains lateral diffusion of plant plasma membrane proteins,” <i>PNAS</i>, vol. 109, no. 31. National Academy of Sciences, pp. 12805–12810, 2012."},"_id":"3113","author":[{"last_name":"Martinière","first_name":"Alexandre","full_name":"Martinière, Alexandre"},{"full_name":"Lavagi, Irene","last_name":"Lavagi","first_name":"Irene"},{"first_name":"Gayathri","last_name":"Nageswaran","full_name":"Nageswaran, Gayathri"},{"last_name":"Rolfe","first_name":"Daniel","full_name":"Rolfe, Daniel J"},{"full_name":"Maneta-Peyret, Lilly","last_name":"Maneta Peyret","first_name":"Lilly"},{"full_name":"Luu, Doan-Trung","first_name":"Doan","last_name":"Luu"},{"full_name":"Botchway, Stanley W","last_name":"Botchway","first_name":"Stanley"},{"full_name":"Webb, Stephen E","last_name":"Webb","first_name":"Stephen"},{"first_name":"Sebastien","last_name":"Mongrand","full_name":"Mongrand, Sebastien"},{"full_name":"Maurel, Christophe","last_name":"Maurel","first_name":"Christophe"},{"first_name":"Marisa","last_name":"Martin Fernandez","full_name":"Martin-Fernandez, Marisa L"},{"last_name":"Kleine Vehn","first_name":"Jürgen","full_name":"Kleine-Vehn, Jürgen"},{"last_name":"Friml","first_name":"Jirí","orcid":"0000-0002-8302-7596","full_name":"Jirí Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Patrick","last_name":"Moreau","full_name":"Moreau, Patrick"},{"first_name":"John","last_name":"Runions","full_name":"Runions, John"}],"publication":"PNAS","volume":109,"date_created":"2018-12-11T12:01:28Z","date_published":"2012-07-31T00:00:00Z","doi":"10.1073/pnas.1202040109","extern":1,"day":"31","publisher":"National Academy of Sciences","month":"07","publication_status":"published","date_updated":"2021-01-12T07:41:09Z","abstract":[{"lang":"eng","text":"A cell membrane can be considered a liquid-phase plane in which lipids and proteins theoretically are free to diffuse. Numerous reports,however, describe retarded diffusion ofmembrane proteins in animal cells. This anomalous diffusion results from a combination of structuring factors including protein-protein interactions, cytoskeleton corralling, and lipid organization into microdomains. In plant cells, plasma-membrane (PM) proteins have been described as relatively immobile, but the control mechanisms that structure the PM have not been studied. Here, we use fluorescence recovery after photobleaching to estimate mobility of a set of minimal PM proteins. These proteins consist only of a PM-anchoring domain fused to a fluorescent protein, but their mobilities remained limited, as is the case for many full-length proteins. Neither the cytoskeleton nor membrane microdomain structure was involved in constraining the diffusion of these proteins. The cell wall, however, was shown to have a crucial role in immobilizing PM proteins. In addition, by single-molecule fluorescence imaging we confirmed that the pattern of cellulose deposition in the cell wall affects the trajectory and speed ofPMprotein diffusion. Regulation ofPMprotein dynamics by the plant cell wall can be interpreted as a mechanism for regulating protein interactions in processes such as trafficking and signal transduction."}],"year":"2012","page":"12805 - 12810","publist_id":"3586","intvolume":"       109","title":"Cell wall constrains lateral diffusion of plant plasma membrane proteins","status":"public","type":"journal_article","quality_controlled":0,"issue":"31"},{"intvolume":"         3","type":"journal_article","title":"ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis","status":"public","issue":"AN 941","quality_controlled":0,"month":"07","publisher":"Nature Publishing Group","date_updated":"2021-01-12T07:41:09Z","abstract":[{"text":"Auxin is a key coordinative signal required for many aspects of plant development and its levels are controlled by auxin metabolism and intercellular auxin transport. Here we find that a member of PIN auxin transporter family, PIN8 is expressed in male gametophyte of Arabidopsis thaliana and has a crucial role in pollen development and functionality. Ectopic expression in sporophytic tissues establishes a role of PIN8 in regulating auxin homoeostasis and metabolism. PIN8 co-localizes with PIN5 to the endoplasmic reticulum (ER) where it acts as an auxin transporter. Genetic analyses reveal an antagonistic action of PIN5 and PIN8 in the regulation of intracellular auxin homoeostasis and gametophyte as well as sporophyte development. Our results reveal a role of the auxin transport in male gametophyte development in which the distinct actions of ER-localized PIN transporters regulate cellular auxin homoeostasis and maintain the auxin levels optimal for pollen development and pollen tube growth.","lang":"eng"}],"publication_status":"published","publist_id":"3585","year":"2012","doi":"10.1038/ncomms1941","date_published":"2012-07-03T00:00:00Z","day":"03","extern":1,"_id":"3114","citation":{"ieee":"Z. Ding <i>et al.</i>, “ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis,” <i>Nature Communications</i>, vol. 3, no. AN 941. Nature Publishing Group, 2012.","ama":"Ding Z, Wang B, Moreno I, et al. ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. <i>Nature Communications</i>. 2012;3(AN 941). doi:<a href=\"https://doi.org/10.1038/ncomms1941\">10.1038/ncomms1941</a>","short":"Z. Ding, B. Wang, I. Moreno, N. Dupláková, S. Simon, N. Carraro, J. Reemmer, A. Pěnčík, X. Chen, R. Tejos, P. Skůpa, S. Pollmann, J. Mravec, J. Petrášek, E. Zažímalová, D. Honys, J. Rolčík, A. Murphy, A. Orellana, M. Geisler, J. Friml, Nature Communications 3 (2012).","ista":"Ding Z, Wang B, Moreno I, Dupláková N, Simon S, Carraro N, Reemmer J, Pěnčík A, Chen X, Tejos R, Skůpa P, Pollmann S, Mravec J, Petrášek J, Zažímalová E, Honys D, Rolčík J, Murphy A, Orellana A, Geisler M, Friml J. 2012. ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. Nature Communications. 3(AN 941).","apa":"Ding, Z., Wang, B., Moreno, I., Dupláková, N., Simon, S., Carraro, N., … Friml, J. (2012). ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms1941\">https://doi.org/10.1038/ncomms1941</a>","chicago":"Ding, Zhaojun, Bangjun Wang, Ignacio Moreno, Nikoleta Dupláková, Sibu Simon, Nicola Carraro, Jesica Reemmer, et al. “ER-Localized Auxin Transporter PIN8 Regulates Auxin Homeostasis and Male Gametophyte Development in Arabidopsis.” <i>Nature Communications</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/ncomms1941\">https://doi.org/10.1038/ncomms1941</a>.","mla":"Ding, Zhaojun, et al. “ER-Localized Auxin Transporter PIN8 Regulates Auxin Homeostasis and Male Gametophyte Development in Arabidopsis.” <i>Nature Communications</i>, vol. 3, no. AN 941, Nature Publishing Group, 2012, doi:<a href=\"https://doi.org/10.1038/ncomms1941\">10.1038/ncomms1941</a>."},"author":[{"full_name":"Ding, Zhaojun","last_name":"Ding","first_name":"Zhaojun"},{"first_name":"Bangjun","last_name":"Wang","full_name":"Wang, Bangjun"},{"last_name":"Moreno","first_name":"Ignacio","full_name":"Moreno, Ignacio"},{"full_name":"Dupláková, Nikoleta","last_name":"Dupláková","first_name":"Nikoleta"},{"orcid":"0000-0002-1998-6741","full_name":"Sibu Simon","last_name":"Simon","first_name":"Sibu","id":"4542EF9A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Carraro, Nicola","last_name":"Carraro","first_name":"Nicola"},{"first_name":"Jesica","last_name":"Reemmer","full_name":"Reemmer, Jesica"},{"first_name":"Aleš","last_name":"Pěnčík","full_name":"Pěnčík, Aleš"},{"id":"4E5ADCAA-F248-11E8-B48F-1D18A9856A87","first_name":"Xu","last_name":"Chen","full_name":"Xu Chen"},{"full_name":"Tejos, Ricardo I","first_name":"Ricardo","last_name":"Tejos"},{"first_name":"Petr","last_name":"Skůpa","full_name":"Skůpa, Petr"},{"full_name":"Pollmann, Stephan","last_name":"Pollmann","first_name":"Stephan"},{"first_name":"Jozef","last_name":"Mravec","full_name":"Mravec, Jozef"},{"full_name":"Petrášek, Jan","first_name":"Jan","last_name":"Petrášek"},{"full_name":"Zažímalová, Eva","last_name":"Zažímalová","first_name":"Eva"},{"last_name":"Honys","first_name":"David","full_name":"Honys, David"},{"first_name":"Jakub","last_name":"Rolčík","full_name":"Rolčík, Jakub"},{"last_name":"Murphy","first_name":"Angus","full_name":"Murphy, Angus S"},{"full_name":"Orellana, Ariel","last_name":"Orellana","first_name":"Ariel"},{"first_name":"Markus","last_name":"Geisler","full_name":"Geisler, Markus"},{"last_name":"Friml","first_name":"Jirí","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"date_created":"2018-12-11T12:01:28Z","volume":3,"publication":"Nature Communications"},{"quality_controlled":"1","oa_version":"Preprint","arxiv":1,"status":"public","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","related_material":{"record":[{"relation":"earlier_version","id":"3329","status":"public"}]},"intvolume":"        48","publist_id":"3584","external_id":{"isi":["000311503200006"],"arxiv":["1109.2158"]},"abstract":[{"lang":"eng","text":"We consider the offset-deconstruction problem: Given a polygonal shape Q with n vertices, can it be expressed, up to a tolerance ε in Hausdorff distance, as the Minkowski sum of another polygonal shape P with a disk of fixed radius? If it does, we also seek a preferably simple-looking solution P; then, P's offset constitutes an accurate, vertex-reduced, and smoothened approximation of Q. We give an O(nlogn)-time exact decision algorithm that handles any polygonal shape, assuming the real-RAM model of computation. A variant of the algorithm, which we have implemented using the cgal library, is based on rational arithmetic and answers the same deconstruction problem up to an uncertainty parameter δ its running time additionally depends on δ. If the input shape is found to be approximable, this algorithm also computes an approximate solution for the problem. It also allows us to solve parameter-optimization problems induced by the offset-deconstruction problem. For convex shapes, the complexity of the exact decision algorithm drops to O(n), which is also the time required to compute a solution P with at most one more vertex than a vertex-minimal one."}],"date_updated":"2025-09-30T08:01:36Z","month":"12","article_processing_charge":"No","doi":"10.1007/s00454-012-9441-5","department":[{"_id":"HeEd"}],"date_published":"2012-12-01T00:00:00Z","language":[{"iso":"eng"}],"acknowledgement":"We thank Eyal Flato (Plataine Ltd.) for raising the offset-deconstruction problem in connection with wood cutting. We also thank Tim Bretl (UIUC) for suggesting the digital-pen offset-deconstruction problem. This work has been supported in part by the Israel Science Foundation (grant no. 1102/11), by the German–Israeli Foundation (grant no. 969/07), by the Hermann Minkowski–Minerva Center for Geometry at Tel Aviv University, and by the EU Project under Contract No. 255827 (CGL—Computational Geometry Learning).\r\n","publication":"Discrete & Computational Geometry","author":[{"first_name":"Eric","last_name":"Berberich","full_name":"Berberich, Eric"},{"full_name":"Halperin, Dan","last_name":"Halperin","first_name":"Dan"},{"id":"36E4574A-F248-11E8-B48F-1D18A9856A87","first_name":"Michael","last_name":"Kerber","orcid":"0000-0002-8030-9299","full_name":"Kerber, Michael"},{"last_name":"Pogalnikova","first_name":"Roza","full_name":"Pogalnikova, Roza"}],"_id":"3115","isi":1,"issue":"4","type":"journal_article","title":"Deconstructing approximate offsets","corr_author":"1","year":"2012","page":"964 - 989","publication_status":"published","publisher":"Springer","day":"01","scopus_import":"1","main_file_link":[{"url":"http://arxiv.org/abs/1109.2158","open_access":"1"}],"date_created":"2018-12-11T12:01:28Z","volume":48,"citation":{"ieee":"E. Berberich, D. Halperin, M. Kerber, and R. Pogalnikova, “Deconstructing approximate offsets,” <i>Discrete &#38; Computational Geometry</i>, vol. 48, no. 4. Springer, pp. 964–989, 2012.","short":"E. Berberich, D. Halperin, M. Kerber, R. Pogalnikova, Discrete &#38; Computational Geometry 48 (2012) 964–989.","ama":"Berberich E, Halperin D, Kerber M, Pogalnikova R. Deconstructing approximate offsets. <i>Discrete &#38; Computational Geometry</i>. 2012;48(4):964-989. doi:<a href=\"https://doi.org/10.1007/s00454-012-9441-5\">10.1007/s00454-012-9441-5</a>","ista":"Berberich E, Halperin D, Kerber M, Pogalnikova R. 2012. Deconstructing approximate offsets. Discrete &#38; Computational Geometry. 48(4), 964–989.","apa":"Berberich, E., Halperin, D., Kerber, M., &#38; Pogalnikova, R. (2012). Deconstructing approximate offsets. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-012-9441-5\">https://doi.org/10.1007/s00454-012-9441-5</a>","chicago":"Berberich, Eric, Dan Halperin, Michael Kerber, and Roza Pogalnikova. “Deconstructing Approximate Offsets.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2012. <a href=\"https://doi.org/10.1007/s00454-012-9441-5\">https://doi.org/10.1007/s00454-012-9441-5</a>.","mla":"Berberich, Eric, et al. “Deconstructing Approximate Offsets.” <i>Discrete &#38; Computational Geometry</i>, vol. 48, no. 4, Springer, 2012, pp. 964–89, doi:<a href=\"https://doi.org/10.1007/s00454-012-9441-5\">10.1007/s00454-012-9441-5</a>."}},{"publication_status":"published","publisher":"Elsevier","corr_author":"1","page":"2246 - 2258","year":"2012","type":"journal_article","title":"Minimizing a sum of submodular functions","issue":"15","citation":{"ieee":"V. Kolmogorov, “Minimizing a sum of submodular functions,” <i>Discrete Applied Mathematics</i>, vol. 160, no. 15. Elsevier, pp. 2246–2258, 2012.","short":"V. Kolmogorov, Discrete Applied Mathematics 160 (2012) 2246–2258.","ama":"Kolmogorov V. Minimizing a sum of submodular functions. <i>Discrete Applied Mathematics</i>. 2012;160(15):2246-2258. doi:<a href=\"https://doi.org/10.1016/j.dam.2012.05.025\">10.1016/j.dam.2012.05.025</a>","apa":"Kolmogorov, V. (2012). Minimizing a sum of submodular functions. <i>Discrete Applied Mathematics</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.dam.2012.05.025\">https://doi.org/10.1016/j.dam.2012.05.025</a>","ista":"Kolmogorov V. 2012. Minimizing a sum of submodular functions. Discrete Applied Mathematics. 160(15), 2246–2258.","chicago":"Kolmogorov, Vladimir. “Minimizing a Sum of Submodular Functions.” <i>Discrete Applied Mathematics</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.dam.2012.05.025\">https://doi.org/10.1016/j.dam.2012.05.025</a>.","mla":"Kolmogorov, Vladimir. “Minimizing a Sum of Submodular Functions.” <i>Discrete Applied Mathematics</i>, vol. 160, no. 15, Elsevier, 2012, pp. 2246–58, doi:<a href=\"https://doi.org/10.1016/j.dam.2012.05.025\">10.1016/j.dam.2012.05.025</a>."},"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1006.1990"}],"date_created":"2018-12-11T12:01:29Z","volume":160,"scopus_import":"1","day":"01","abstract":[{"lang":"eng","text":"We consider the problem of minimizing a function represented as a sum of submodular terms. We assume each term allows an efficient computation of exchange capacities. This holds, for example, for terms depending on a small number of variables, or for certain cardinality-dependent terms. A naive application of submodular minimization algorithms would not exploit the existence of specialized exchange capacity subroutines for individual terms. To overcome this, we cast the problem as a submodular flow (SF) problem in an auxiliary graph in such a way that applying most existing SF algorithms would rely only on these subroutines. We then explore in more detail Iwata's capacity scaling approach for submodular flows (Iwata 1997 [19]). In particular, we show how to improve its complexity in the case when the function contains cardinality-dependent terms."}],"date_updated":"2025-09-30T08:01:04Z","month":"10","publist_id":"3582","external_id":{"isi":["000308052600017"]},"status":"public","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","intvolume":"       160","quality_controlled":"1","oa_version":"Preprint","author":[{"id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","first_name":"Vladimir","last_name":"Kolmogorov","full_name":"Kolmogorov, Vladimir"}],"_id":"3117","isi":1,"publication":"Discrete Applied Mathematics","doi":"10.1016/j.dam.2012.05.025","department":[{"_id":"VlKo"}],"date_published":"2012-10-01T00:00:00Z","language":[{"iso":"eng"}],"article_processing_charge":"No"},{"pubrep_id":"602","scopus_import":"1","day":"01","article_number":"53","citation":{"ieee":"M. Bojsen-Hansen, H. Li, and C. Wojtan, “Tracking surfaces with evolving topology,” <i>ACM Transactions on Graphics</i>, vol. 31, no. 4. ACM, 2012.","mla":"Bojsen-Hansen, Morten, et al. “Tracking Surfaces with Evolving Topology.” <i>ACM Transactions on Graphics</i>, vol. 31, no. 4, 53, ACM, 2012, doi:<a href=\"https://doi.org/10.1145/2185520.2185549\">10.1145/2185520.2185549</a>.","chicago":"Bojsen-Hansen, Morten, Hao Li, and Chris Wojtan. “Tracking Surfaces with Evolving Topology.” <i>ACM Transactions on Graphics</i>. ACM, 2012. <a href=\"https://doi.org/10.1145/2185520.2185549\">https://doi.org/10.1145/2185520.2185549</a>.","ista":"Bojsen-Hansen M, Li H, Wojtan C. 2012. Tracking surfaces with evolving topology. ACM Transactions on Graphics. 31(4), 53.","apa":"Bojsen-Hansen, M., Li, H., &#38; Wojtan, C. (2012). Tracking surfaces with evolving topology. <i>ACM Transactions on Graphics</i>. ACM. <a href=\"https://doi.org/10.1145/2185520.2185549\">https://doi.org/10.1145/2185520.2185549</a>","short":"M. Bojsen-Hansen, H. Li, C. Wojtan, ACM Transactions on Graphics 31 (2012).","ama":"Bojsen-Hansen M, Li H, Wojtan C. Tracking surfaces with evolving topology. <i>ACM Transactions on Graphics</i>. 2012;31(4). doi:<a href=\"https://doi.org/10.1145/2185520.2185549\">10.1145/2185520.2185549</a>"},"date_created":"2018-12-11T12:01:29Z","volume":31,"type":"journal_article","file_date_updated":"2020-07-14T12:46:00Z","title":"Tracking surfaces with evolving topology","issue":"4","publisher":"ACM","publication_status":"published","corr_author":"1","year":"2012","acknowledgement":"This work is supported by the SNF fellowship PBEZP2-134464.\r\nWe would like to thank Xiaochen Hu for implementing mesh con- version tools, Duygu Ceylan for helping with the rendering, and Art Tevs for the human performance data comparison. We also thank Nils Thuerey and Christopher Batty for helpful discussions. ","language":[{"iso":"eng"}],"doi":"10.1145/2185520.2185549","department":[{"_id":"ChWo"}],"date_published":"2012-07-01T00:00:00Z","file":[{"file_name":"IST-2016-602-v1+1_topoReg.pdf","creator":"system","date_created":"2018-12-12T10:18:37Z","access_level":"open_access","file_id":"5359","checksum":"1e219c5bf4e5552c1290c62eefa5cd60","content_type":"application/pdf","file_size":44538518,"date_updated":"2020-07-14T12:46:00Z","relation":"main_file"}],"article_processing_charge":"No","_id":"3118","alternative_title":["SIGGRAPH"],"isi":1,"has_accepted_license":"1","author":[{"orcid":"0000-0002-4417-3224","full_name":"Bojsen-Hansen, Morten","first_name":"Morten","last_name":"Bojsen-Hansen","id":"439F0C8C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Li, Hao","last_name":"Li","first_name":"Hao"},{"first_name":"Christopher J","last_name":"Wojtan","full_name":"Wojtan, Christopher J","orcid":"0000-0001-6646-5546","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87"}],"ddc":["000"],"publication":"ACM Transactions on Graphics","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"intvolume":"        31","article_type":"original","status":"public","quality_controlled":"1","oa_version":"Submitted Version","month":"07","date_updated":"2025-09-30T08:00:23Z","abstract":[{"text":"We present a method for recovering a temporally coherent, deforming triangle mesh with arbitrarily changing topology from an incoherent sequence of static closed surfaces. We solve this problem using the surface geometry alone, without any prior information like surface templates or velocity fields. Our system combines a proven strategy for triangle mesh improvement, a robust multi-resolution non-rigid registration routine, and a reliable technique for changing surface mesh topology. We also introduce a novel topological constraint enforcement algorithm to ensure that the output and input always have similar topology. We apply our technique to a series of diverse input data from video reconstructions, physics simulations, and artistic morphs. The structured output of our algorithm allows us to efficiently track information like colors and displacement maps, recover velocity information, and solve PDEs on the mesh as a post process.","lang":"eng"}],"external_id":{"isi":["000308250300029"]},"publist_id":"3581"},{"publication_status":"published","publisher":"ACM","page":"255 - 264","year":"2012","file_date_updated":"2020-07-14T12:46:00Z","title":"Controlling liquids using meshes","type":"conference","citation":{"ieee":"K. Raveendran, N. Thuerey, C. Wojtan, and G. Turk, “Controlling liquids using meshes,” in <i>Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation</i>, Aire-la-Ville, Switzerland, 2012, pp. 255–264.","apa":"Raveendran, K., Thuerey, N., Wojtan, C., &#38; Turk, G. (2012). Controlling liquids using meshes. In <i>Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation</i> (pp. 255–264). Aire-la-Ville, Switzerland: ACM.","ista":"Raveendran K, Thuerey N, Wojtan C, Turk G. 2012. Controlling liquids using meshes. Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation. SCA: ACM SIGGRAPH/Eurographics Symposium on Computer animation, 255–264.","short":"K. Raveendran, N. Thuerey, C. Wojtan, G. Turk, in:, Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation, ACM, 2012, pp. 255–264.","ama":"Raveendran K, Thuerey N, Wojtan C, Turk G. Controlling liquids using meshes. In: <i>Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation</i>. ACM; 2012:255-264.","mla":"Raveendran, Karthik, et al. “Controlling Liquids Using Meshes.” <i>Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation</i>, ACM, 2012, pp. 255–64.","chicago":"Raveendran, Karthik, Nils Thuerey, Chris Wojtan, and Greg Turk. “Controlling Liquids Using Meshes.” In <i>Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation</i>, 255–64. ACM, 2012."},"date_created":"2018-12-11T12:01:30Z","pubrep_id":"600","scopus_import":1,"conference":{"end_date":"2012-07-31","location":"Aire-la-Ville, Switzerland","start_date":"2012-07-29","name":"SCA: ACM SIGGRAPH/Eurographics Symposium on Computer animation"},"day":"29","date_updated":"2023-02-23T11:13:07Z","abstract":[{"lang":"eng","text":"We present an approach for artist-directed animation of liquids using multiple levels of control over the simulation, ranging from the overall tracking of desired shapes to highly detailed secondary effects such as dripping streams, separating sheets of fluid, surface waves and ripples. The first portion of our technique is a volume preserving morph that allows the animator to produce a plausible fluid-like motion from a sparse set of control meshes. By rasterizing the resulting control meshes onto the simulation grid, the mesh velocities act as boundary conditions during the projection step of the fluid simulation. We can then blend this motion together with uncontrolled fluid velocities to achieve a more relaxed control over the fluid that captures natural inertial effects. Our method can produce highly detailed liquid surfaces with control over sub-grid details by using a mesh-based surface tracker on top of a coarse grid-based fluid simulation. We can create ripples and waves on the fluid surface attracting the surface mesh to the control mesh with spring-like forces and also by running a wave simulation over the surface mesh. Our video results demonstrate how our control scheme can be used to create animated characters and shapes that are made of water.\r\n"}],"month":"07","publist_id":"3580","status":"public","related_material":{"link":[{"relation":"table_of_contents","url":"http://dl.acm.org/citation.cfm?id=2422393"}]},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","oa":1,"oa_version":"Submitted Version","quality_controlled":"1","author":[{"last_name":"Raveendran","first_name":"Karthik","full_name":"Raveendran, Karthik"},{"full_name":"Thuerey, Nils","first_name":"Nils","last_name":"Thuerey"},{"id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","last_name":"Wojtan","first_name":"Christopher J","orcid":"0000-0001-6646-5546","full_name":"Wojtan, Christopher J"},{"full_name":"Turk, Greg","first_name":"Greg","last_name":"Turk"}],"has_accepted_license":"1","_id":"3119","ddc":["000"],"publication":"Proceedings of the ACM SIGGRAPH/Eurographics Symposium on Computer Animation","date_published":"2012-07-29T00:00:00Z","department":[{"_id":"ChWo"}],"acknowledgement":"This work was partially funded by NSF grants CCF-0811485 and IIS-1130934. We would like to thank Scanline VFX for additional funding. We would like to thank Jie Tan as well as our anonymous reviewers for their useful suggestions and feedback.","language":[{"iso":"eng"}],"file":[{"file_name":"IST-2016-600-v1+1_ControllingLiquids_Preprint.pdf","checksum":"babda64c24cf90a4d05ae86d712bed08","content_type":"application/pdf","file_id":"4877","date_created":"2018-12-12T10:11:23Z","access_level":"open_access","creator":"system","date_updated":"2020-07-14T12:46:00Z","relation":"main_file","file_size":4939370}]},{"publist_id":"3579","external_id":{"isi":["000307176400007"],"arxiv":["1009.4313"]},"abstract":[{"text":"We introduce a strategy based on Kustin-Miller unprojection that allows us to construct many hundreds of Gorenstein codimension 4 ideals with 9 × 16 resolutions (that is, nine equations and sixteen first syzygies). Our two basic games are called Tom and Jerry; the main application is the biregular construction of most of the anticanonically polarised Mori Fano 3-folds of Altinok's thesis. There are 115 cases whose numerical data (in effect, the Hilbert series) allow a Type I projection. In every case, at least one Tom and one Jerry construction works, providing at least two deformation families of quasismooth Fano 3-folds having the same numerics but different topology. © 2012 Copyright Foundation Compositio Mathematica.","lang":"eng"}],"date_updated":"2025-09-30T07:59:55Z","month":"07","oa_version":"Preprint","quality_controlled":"1","arxiv":1,"status":"public","intvolume":"       148","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication":"Compositio Mathematica","author":[{"full_name":"Brown, Gavin","last_name":"Brown","first_name":"Gavin"},{"id":"36E4574A-F248-11E8-B48F-1D18A9856A87","last_name":"Kerber","first_name":"Michael","full_name":"Kerber, Michael","orcid":"0000-0002-8030-9299"},{"full_name":"Reid, Miles","last_name":"Reid","first_name":"Miles"}],"isi":1,"_id":"3120","article_processing_charge":"No","date_published":"2012-07-01T00:00:00Z","department":[{"_id":"HeEd"}],"doi":"10.1112/S0010437X11007226","acknowledgement":"This research is supported by the Korean Government WCU Grant R33-2008-000-10101-0.","language":[{"iso":"eng"}],"page":"1171 - 1194","year":"2012","publication_status":"published","publisher":"Cambridge University Press","issue":"4","title":"Fano 3 folds in codimension 4 Tom and Jerry Part I","type":"journal_article","main_file_link":[{"url":"http://arxiv.org/abs/1009.4313","open_access":"1"}],"volume":148,"date_created":"2018-12-11T12:01:30Z","citation":{"mla":"Brown, Gavin, et al. “Fano 3 Folds in Codimension 4 Tom and Jerry Part I.” <i>Compositio Mathematica</i>, vol. 148, no. 4, Cambridge University Press, 2012, pp. 1171–94, doi:<a href=\"https://doi.org/10.1112/S0010437X11007226\">10.1112/S0010437X11007226</a>.","chicago":"Brown, Gavin, Michael Kerber, and Miles Reid. “Fano 3 Folds in Codimension 4 Tom and Jerry Part I.” <i>Compositio Mathematica</i>. Cambridge University Press, 2012. <a href=\"https://doi.org/10.1112/S0010437X11007226\">https://doi.org/10.1112/S0010437X11007226</a>.","apa":"Brown, G., Kerber, M., &#38; Reid, M. (2012). Fano 3 folds in codimension 4 Tom and Jerry Part I. <i>Compositio Mathematica</i>. Cambridge University Press. <a href=\"https://doi.org/10.1112/S0010437X11007226\">https://doi.org/10.1112/S0010437X11007226</a>","ista":"Brown G, Kerber M, Reid M. 2012. Fano 3 folds in codimension 4 Tom and Jerry Part I. Compositio Mathematica. 148(4), 1171–1194.","ama":"Brown G, Kerber M, Reid M. Fano 3 folds in codimension 4 Tom and Jerry Part I. <i>Compositio Mathematica</i>. 2012;148(4):1171-1194. doi:<a href=\"https://doi.org/10.1112/S0010437X11007226\">10.1112/S0010437X11007226</a>","short":"G. Brown, M. Kerber, M. Reid, Compositio Mathematica 148 (2012) 1171–1194.","ieee":"G. Brown, M. Kerber, and M. Reid, “Fano 3 folds in codimension 4 Tom and Jerry Part I,” <i>Compositio Mathematica</i>, vol. 148, no. 4. Cambridge University Press, pp. 1171–1194, 2012."},"day":"01","scopus_import":"1"},{"isi":1,"_id":"3121","author":[{"full_name":"Williams, Courtney","first_name":"Courtney","last_name":"Williams"},{"full_name":"Chen, Wenyan","last_name":"Chen","first_name":"Wenyan"},{"last_name":"Lee","first_name":"Chia","full_name":"Lee, Chia"},{"full_name":"Yaeger, Daniel","last_name":"Yaeger","first_name":"Daniel"},{"id":"36C4978E-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas","last_name":"Vyleta","full_name":"Vyleta, Nicholas"},{"last_name":"Smith","first_name":"Stephen","full_name":"Smith, Stephen"}],"publication":"Nature Neuroscience","language":[{"iso":"eng"}],"acknowledgement":"The work was supported by the US National Institutes of Health (DA027110 and GM097433) and OCTRI. C.W. and N.P.V. were supported by a grant from the National Heart, Lung, and Blood Institute (T32HL033808).\r\nWe thank M. Andresen and K. Khodakhah for helpful comments. ","date_published":"2012-09-01T00:00:00Z","department":[{"_id":"PeJo"}],"doi":"10.1038/nn.3162","article_processing_charge":"No","month":"09","date_updated":"2025-09-30T07:59:27Z","abstract":[{"text":"Voltage-activated Ca(2+) channels (VACCs) mediate Ca(2+) influx to trigger action potential-evoked neurotransmitter release, but the mechanism by which Ca(2+) regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type.","lang":"eng"}],"external_id":{"isi":["000308072600008"],"pmid":["22842148"]},"publist_id":"3578","pmid":1,"intvolume":"        15","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","oa_version":"Submitted Version","quality_controlled":"1","citation":{"chicago":"Williams, Courtney, Wenyan Chen, Chia Lee, Daniel Yaeger, Nicholas Vyleta, and Stephen Smith. “Coactivation of Multiple Tightly Coupled Calcium Channels Triggers Spontaneous Release of GABA.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nn.3162\">https://doi.org/10.1038/nn.3162</a>.","mla":"Williams, Courtney, et al. “Coactivation of Multiple Tightly Coupled Calcium Channels Triggers Spontaneous Release of GABA.” <i>Nature Neuroscience</i>, vol. 15, no. 9, Nature Publishing Group, 2012, pp. 1195–97, doi:<a href=\"https://doi.org/10.1038/nn.3162\">10.1038/nn.3162</a>.","ama":"Williams C, Chen W, Lee C, Yaeger D, Vyleta N, Smith S. Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. <i>Nature Neuroscience</i>. 2012;15(9):1195-1197. doi:<a href=\"https://doi.org/10.1038/nn.3162\">10.1038/nn.3162</a>","short":"C. Williams, W. Chen, C. Lee, D. Yaeger, N. Vyleta, S. Smith, Nature Neuroscience 15 (2012) 1195–1197.","apa":"Williams, C., Chen, W., Lee, C., Yaeger, D., Vyleta, N., &#38; Smith, S. (2012). Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn.3162\">https://doi.org/10.1038/nn.3162</a>","ista":"Williams C, Chen W, Lee C, Yaeger D, Vyleta N, Smith S. 2012. Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. Nature Neuroscience. 15(9), 1195–1197.","ieee":"C. Williams, W. Chen, C. Lee, D. Yaeger, N. Vyleta, and S. Smith, “Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA,” <i>Nature Neuroscience</i>, vol. 15, no. 9. Nature Publishing Group, pp. 1195–1197, 2012."},"volume":15,"date_created":"2018-12-11T12:01:30Z","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431448/"}],"scopus_import":"1","day":"01","publisher":"Nature Publishing Group","publication_status":"published","page":"1195 - 1197","year":"2012","title":"Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA","type":"journal_article","issue":"9"}]