[{"pmid":1,"citation":{"ieee":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E. J. Lambie, and B. Conradt, “Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo,” Nature Communications, vol. 16. Springer Nature, 2025.","ama":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. Nature Communications. 2025;16. doi:10.1038/s41467-025-62484-5","short":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E.J. Lambie, B. Conradt, Nature Communications 16 (2025).","apa":"Segos, I., Van Eeckhoven, J., Berger, S., Mishra, N., Lambie, E. J., & Conradt, B. (2025). Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-62484-5","ista":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. 2025. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. Nature Communications. 16, 7174.","chicago":"Segos, Ioannis, Jens Van Eeckhoven, Simon Berger, Nikhil Mishra, Eric J. Lambie, and Barbara Conradt. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” Nature Communications. Springer Nature, 2025. https://doi.org/10.1038/s41467-025-62484-5.","mla":"Segos, Ioannis, et al. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” Nature Communications, vol. 16, 7174, Springer Nature, 2025, doi:10.1038/s41467-025-62484-5."},"has_accepted_license":"1","title":"Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo","oa_version":"Published Version","acknowledgement":"We thank members of the Conradt lab, the Center for Cell and Molecular Dynamics (https://www.uclccmd.co.uk/) and T. Schedl for discussions and comments on the manuscript. We thank L. McGuinness for excellent technical support. Some strains were provided by the Caenorhabditis Genetics Center (CGC), which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We thank Alex Hajnal (University of Zurich, Switzerland) and Andrew deMello (ETH Zurich, Switzerland) for their support of S.B. This work was supported by a predoctoral fellowship from the Studienstiftung des deutschen Volkes to NM, funds from UCL (Division of Biosciences, UCL LSM Capital Equipment Fund) to B.C., and a Wolfson Fellowship from the Royal Society (https://royalsociety.org/) to B.C. (RSWF\\R1\\180008), and the Biotechnology and Biological Sciences Research Council (https://bbsrc.ukri.org/) (BB/V007572/1 and BB/V015648/1to B.C.).","scopus_import":"1","OA_type":"gold","article_type":"original","article_processing_charge":"Yes","DOAJ_listed":"1","_id":"20183","PlanS_conform":"1","language":[{"iso":"eng"}],"oa":1,"author":[{"first_name":"Ioannis","full_name":"Segos, Ioannis","last_name":"Segos"},{"first_name":"Jens","full_name":"Van Eeckhoven, Jens","last_name":"Van Eeckhoven"},{"last_name":"Berger","full_name":"Berger, Simon","first_name":"Simon"},{"first_name":"Nikhil","id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","last_name":"Mishra","orcid":"0000-0002-6425-5788","full_name":"Mishra, Nikhil"},{"last_name":"Lambie","full_name":"Lambie, Eric J.","first_name":"Eric J."},{"first_name":"Barbara","full_name":"Conradt, Barbara","last_name":"Conradt"}],"type":"journal_article","day":"04","status":"public","OA_place":"publisher","quality_controlled":"1","month":"08","article_number":"7174","publication_identifier":{"eissn":["2041-1723"]},"publisher":"Springer Nature","file_date_updated":"2025-09-01T09:46:44Z","intvolume":" 16","file":[{"creator":"dernst","access_level":"open_access","date_updated":"2025-09-01T09:46:44Z","file_name":"2025_NatureComm_Segos.pdf","file_size":3775190,"checksum":"f28e73963ea1f55876d0d1afca0f706a","file_id":"20261","relation":"main_file","date_created":"2025-09-01T09:46:44Z","content_type":"application/pdf","success":1}],"publication":"Nature Communications","publication_status":"published","external_id":{"pmid":["40759648"]},"department":[{"_id":"CaHe"}],"abstract":[{"lang":"eng","text":"The unequal segregation of organelles has been proposed to be an intrinsic mechanism that contributes to cell fate divergence during asymmetric cell division; however, in vivo evidence is sparse. Using super-resolution microscopy, we analysed the segregation of organelles during the division of the neuroblast QL.p in C. elegans larvae. QL.p divides to generate a daughter that survives, QL.pa, and a daughter that dies, QL.pp. We found that mitochondria segregate unequally by density and morphology and that this is dependent on mitochondrial dynamics. Furthermore, we found that mitochondrial density in QL.pp correlates with the time it takes QL.pp to die. We propose that low mitochondrial density in QL.pp promotes the cell death fate and ensures that QL.pp dies in a highly reproducible and timely manner. Our results provide in vivo evidence that the unequal segregation of mitochondria can contribute to cell fate divergence during asymmetric cell division in a developing animal."}],"doi":"10.1038/s41467-025-62484-5","ddc":["570"],"date_published":"2025-08-04T00:00:00Z","volume":16,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_updated":"2025-09-01T09:47:29Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2025","date_created":"2025-08-17T22:01:35Z"},{"date_created":"2025-08-17T22:01:35Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s42003-025-08589-5"}],"year":"2025","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2025-09-30T14:18:46Z","volume":8,"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"date_published":"2025-08-02T00:00:00Z","ddc":["570"],"doi":"10.1038/s42003-025-08589-5","abstract":[{"lang":"eng","text":"Specialized DNA polymerases facilitate various cellular processes. Despite extensive research, the mutagenic effects of these error-prone enzymes on genomes are not fully understood. Here we show that Pol IV promotes genomic instability in Pseudomonas aeruginosa by misincorporating oxidized guanine nucleotides. This activity led to a distinctive mutational signature, characterized by A-to-C transversions occurring preferentially at AT sites flanked by a 5’G and/or 3’C. Furthermore, Pol IV preferentially targeted pathogenicity genes located at specific chromosomal locations near the replication termination region and rRNA-encoding operons. Half of the mutation events catalyzed by Pol IV impaired gene function. This can be attributed to the bias of Pol IV for mutating codons with its preferred sequence contexts, leading to substitutions to unreactive alanine and glycine residues. Remarkably, mutation signatures identified for Pol IV were found in clinical isolate genomes of P. aeruginosa, providing compelling evidence for its role in genetic diversification during pathogen adaptation."}],"department":[{"_id":"PaSc"},{"_id":"GradSch"}],"external_id":{"isi":["001541878500001"],"pmid":["40753298"]},"publication_status":"published","publication":"Communications Biology","intvolume":" 8","publisher":"Springer Nature","article_number":"1148","publication_identifier":{"eissn":["2399-3642"]},"quality_controlled":"1","month":"08","OA_place":"publisher","status":"public","day":"02","type":"journal_article","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","author":[{"full_name":"Castell, Sofía D.","last_name":"Castell","first_name":"Sofía D."},{"first_name":"Consuelo M.","full_name":"Fernandez, Consuelo M.","last_name":"Fernandez"},{"last_name":"Tumas","full_name":"Tumas, Ignacio N.","first_name":"Ignacio N."},{"last_name":"Margara","full_name":"Margara, Lucía M.","first_name":"Lucía M."},{"first_name":"Maria C","full_name":"Miserendino, Maria C","last_name":"Miserendino","id":"273e0cbd-72f0-11ef-b75a-f9f932e292fa"},{"first_name":"Danilo G.","last_name":"Ceschin","full_name":"Ceschin, Danilo G."},{"last_name":"Pezza","full_name":"Pezza, Roberto J.","first_name":"Roberto J."},{"first_name":"Mariela R.","full_name":"Monti, Mariela R.","last_name":"Monti"}],"language":[{"iso":"eng"}],"oa":1,"PlanS_conform":"1","_id":"20184","DOAJ_listed":"1","article_type":"original","article_processing_charge":"Yes","OA_type":"gold","isi":1,"acknowledgement":"This work was supported by the Secretaría de Ciencia y Técnica (33620230100926CB), Universidad Nacional de Córdoba; and the Agencia Nacional de Promoción Científica y Técnica (PICT 2018-4527).\r\n\r\n","scopus_import":"1","oa_version":"Published Version","title":"The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa","has_accepted_license":"1","citation":{"short":"S.D. Castell, C.M. Fernandez, I.N. Tumas, L.M. Margara, M.C. Miserendino, D.G. Ceschin, R.J. Pezza, M.R. Monti, Communications Biology 8 (2025).","ama":"Castell SD, Fernandez CM, Tumas IN, et al. The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. Communications Biology. 2025;8. doi:10.1038/s42003-025-08589-5","ieee":"S. D. Castell et al., “The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa,” Communications Biology, vol. 8. Springer Nature, 2025.","apa":"Castell, S. D., Fernandez, C. M., Tumas, I. N., Margara, L. M., Miserendino, M. C., Ceschin, D. G., … Monti, M. R. (2025). The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. Communications Biology. Springer Nature. https://doi.org/10.1038/s42003-025-08589-5","ista":"Castell SD, Fernandez CM, Tumas IN, Margara LM, Miserendino MC, Ceschin DG, Pezza RJ, Monti MR. 2025. The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. Communications Biology. 8, 1148.","chicago":"Castell, Sofía D., Consuelo M. Fernandez, Ignacio N. Tumas, Lucía M. Margara, Maria C Miserendino, Danilo G. Ceschin, Roberto J. Pezza, and Mariela R. Monti. “The Low-Fidelity DNA Pol IV Accelerates Evolution of Pathogenicity Genes in Pseudomonas Aeruginosa.” Communications Biology. Springer Nature, 2025. https://doi.org/10.1038/s42003-025-08589-5.","mla":"Castell, Sofía D., et al. “The Low-Fidelity DNA Pol IV Accelerates Evolution of Pathogenicity Genes in Pseudomonas Aeruginosa.” Communications Biology, vol. 8, 1148, Springer Nature, 2025, doi:10.1038/s42003-025-08589-5."},"pmid":1},{"publication_status":"published","department":[{"_id":"VaKa"}],"external_id":{"isi":["001546433200002"],"arxiv":["2501.08849"]},"abstract":[{"lang":"eng","text":"We show a local rigidity result for the integrability of symplectic billiards. We prove that any domain which is close to an ellipse, and for which the symplectic billiard map is rationally integrable must be an ellipse as well. This is in spirit of the result of [2] for Birkhoff billiards."}],"ec_funded":1,"doi":"10.1007/s12220-025-02148-4","file_date_updated":"2025-12-30T09:28:58Z","publication":"Journal of Geometric Analysis","file":[{"date_created":"2025-12-30T09:28:58Z","content_type":"application/pdf","success":1,"file_id":"20907","checksum":"ed86500742b3fd93db3287558a630383","relation":"main_file","access_level":"open_access","file_name":"2025_JourGeomAnalysis_Tsodikovich.pdf","file_size":484344,"date_updated":"2025-12-30T09:28:58Z","creator":"dernst"}],"intvolume":" 35","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2025","date_created":"2025-08-17T22:01:35Z","date_published":"2025-08-07T00:00:00Z","ddc":["510"],"project":[{"name":"Spectral rigidity and integrability for billiards and geodesic flows","_id":"9B8B92DE-BA93-11EA-9121-9846C619BF3A","grant_number":"885707","call_identifier":"H2020"}],"date_updated":"2025-12-30T09:29:27Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":35,"title":"Local rigidity for symplectic billiards","acknowledgement":"The author would like to thank Corentin Fierobe, Vadim Kaloshin, Illya Koval and Yunzhe Li for useful discussions. The author would also like to thank the referee for useful remarks. Open access funding provided by Institute of Science and Technology (IST Austria). European Research Council (885707) Mr Daniel Tsodikovich","oa_version":"Published Version","scopus_import":"1","OA_type":"hybrid","isi":1,"arxiv":1,"citation":{"chicago":"Tsodikovich, Daniel. “Local Rigidity for Symplectic Billiards.” Journal of Geometric Analysis. Springer Nature, 2025. https://doi.org/10.1007/s12220-025-02148-4.","mla":"Tsodikovich, Daniel. “Local Rigidity for Symplectic Billiards.” Journal of Geometric Analysis, vol. 35, no. 10, 306, Springer Nature, 2025, doi:10.1007/s12220-025-02148-4.","short":"D. Tsodikovich, Journal of Geometric Analysis 35 (2025).","ama":"Tsodikovich D. Local rigidity for symplectic billiards. Journal of Geometric Analysis. 2025;35(10). doi:10.1007/s12220-025-02148-4","ieee":"D. Tsodikovich, “Local rigidity for symplectic billiards,” Journal of Geometric Analysis, vol. 35, no. 10. Springer Nature, 2025.","ista":"Tsodikovich D. 2025. Local rigidity for symplectic billiards. Journal of Geometric Analysis. 35(10), 306.","apa":"Tsodikovich, D. (2025). Local rigidity for symplectic billiards. Journal of Geometric Analysis. Springer Nature. https://doi.org/10.1007/s12220-025-02148-4"},"has_accepted_license":"1","day":"07","type":"journal_article","OA_place":"publisher","status":"public","month":"08","quality_controlled":"1","article_number":"306","publisher":"Springer Nature","publication_identifier":{"issn":["1050-6926"]},"article_type":"original","article_processing_charge":"Yes (via OA deal)","PlanS_conform":"1","_id":"20185","corr_author":"1","issue":"10","language":[{"iso":"eng"}],"oa":1,"author":[{"first_name":"Daniel","id":"04531810-fb3e-11ef-87f0-800a4ce333db","full_name":"Tsodikovich, Daniel","last_name":"Tsodikovich"}]},{"date_created":"2025-08-17T22:01:36Z","year":"2025","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","volume":62,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_updated":"2025-09-30T14:20:11Z","project":[{"grant_number":"F8502","_id":"34a1b658-11ca-11ed-8bc3-c75229f0241e","name":"Interface Theory for Security and Privacy"}],"ddc":["000"],"date_published":"2025-09-01T00:00:00Z","doi":"10.1007/s00236-025-00502-1","abstract":[{"lang":"eng","text":"Enforcement of information-flow policies has been extensively studied by language-based approaches over the past few decades. In this paper, we propose an alternative, novel, general, and effective approach using enforcement of hyperproperties– a powerful formalism for expressing and reasoning about a wide range of information-flow security policies. We study black- vs. gray- vs. white-box enforcement of hyperproperties expressed by nondeterministic finite-word hyperautomata (NFH), where the enforcer has null, some, or complete information about the implementation of the system under scrutiny. Given an NFH, in order to generate a runtime enforcer, we reduce the problem to controller synthesis for hyperproperties and subsequently to the satisfiability problem for quantified Boolean formulas (QBFs). The resulting enforcers are transferable with low-overhead. We conduct a rich set of case studies, including information-flow control for JavaScript code, as well as synthesizing obfuscators for control plants."}],"external_id":{"isi":["001546115300001"]},"department":[{"_id":"ToHe"}],"publication_status":"published","file":[{"relation":"main_file","file_id":"20267","checksum":"90a43350fd4a8c5cb5b1b0e1aea7970d","content_type":"application/pdf","success":1,"date_created":"2025-09-02T05:53:47Z","creator":"dernst","date_updated":"2025-09-02T05:53:47Z","file_name":"2025_ActaInformatica_Hsu.pdf","file_size":6505049,"access_level":"open_access"}],"publication":"Acta Informatica","intvolume":" 62","file_date_updated":"2025-09-02T05:53:47Z","article_number":"30","publisher":"Springer Nature","publication_identifier":{"issn":["0001-5903"],"eissn":["1432-0525"]},"month":"09","quality_controlled":"1","status":"public","OA_place":"publisher","type":"journal_article","day":"01","author":[{"first_name":"Tzu Han","full_name":"Hsu, Tzu Han","last_name":"Hsu"},{"last_name":"Oliveira Da Costa","full_name":"Oliveira Da Costa, Ana A","id":"8b282559-50b0-11ef-861e-d6ace0d92e9b","first_name":"Ana A"},{"full_name":"Wintenberg, Andrew","last_name":"Wintenberg","first_name":"Andrew"},{"full_name":"Bartocci, Ezio","last_name":"Bartocci","first_name":"Ezio"},{"first_name":"Borzoo","last_name":"Bonakdarpour","full_name":"Bonakdarpour, Borzoo"}],"language":[{"iso":"eng"}],"oa":1,"_id":"20186","corr_author":"1","issue":"3","PlanS_conform":"1","article_type":"original","article_processing_charge":"Yes (via OA deal)","isi":1,"OA_type":"hybrid","oa_version":"Published Version","scopus_import":"1","acknowledgement":"This project was funded in part by the Austrian Science Fund (FWF) SFB project SpyCoDe F8502, Vienna Science and Technology Fund (WWTF) [10.47379/ICT19018] (ProbInG) and WWTF project ICT22-023 (TAIGER), National Science Foundation (NSF) CPS Award 1837680, NSF award ECCS-2144416 and NSF SaTC Award 2245114. Open access funding provided by Institute of Science and Technology (IST Austria).","title":"Gray-box runtime enforcement of hyperproperties","has_accepted_license":"1","citation":{"mla":"Hsu, Tzu Han, et al. “Gray-Box Runtime Enforcement of Hyperproperties.” Acta Informatica, vol. 62, no. 3, 30, Springer Nature, 2025, doi:10.1007/s00236-025-00502-1.","chicago":"Hsu, Tzu Han, Ana A Oliveira da Costa, Andrew Wintenberg, Ezio Bartocci, and Borzoo Bonakdarpour. “Gray-Box Runtime Enforcement of Hyperproperties.” Acta Informatica. Springer Nature, 2025. https://doi.org/10.1007/s00236-025-00502-1.","ista":"Hsu TH, Oliveira da Costa AA, Wintenberg A, Bartocci E, Bonakdarpour B. 2025. Gray-box runtime enforcement of hyperproperties. Acta Informatica. 62(3), 30.","apa":"Hsu, T. H., Oliveira da Costa, A. A., Wintenberg, A., Bartocci, E., & Bonakdarpour, B. (2025). Gray-box runtime enforcement of hyperproperties. Acta Informatica. Springer Nature. https://doi.org/10.1007/s00236-025-00502-1","ama":"Hsu TH, Oliveira da Costa AA, Wintenberg A, Bartocci E, Bonakdarpour B. Gray-box runtime enforcement of hyperproperties. Acta Informatica. 2025;62(3). doi:10.1007/s00236-025-00502-1","short":"T.H. Hsu, A.A. Oliveira da Costa, A. Wintenberg, E. Bartocci, B. Bonakdarpour, Acta Informatica 62 (2025).","ieee":"T. H. Hsu, A. A. Oliveira da Costa, A. Wintenberg, E. Bartocci, and B. Bonakdarpour, “Gray-box runtime enforcement of hyperproperties,” Acta Informatica, vol. 62, no. 3. Springer Nature, 2025."}},{"pmid":1,"citation":{"apa":"Babic, D., Abualia, R., Fiedler, L., Qi, L., Tellier, F., Smoljan, A., … Friml, J. (2025). Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. Plant Journal. Wiley. https://doi.org/10.1111/tpj.70396","ista":"Babic D, Abualia R, Fiedler L, Qi L, Tellier F, Smoljan A, Rakusova H, Valošek P, Han H, Benková E, Faure JD, Friml J. 2025. Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. Plant Journal. 123(3), e70396.","short":"D. Babic, R. Abualia, L. Fiedler, L. Qi, F. Tellier, A. Smoljan, H. Rakusova, P. Valošek, H. Han, E. Benková, J.D. Faure, J. Friml, Plant Journal 123 (2025).","ieee":"D. Babic et al., “Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development,” Plant Journal, vol. 123, no. 3. Wiley, 2025.","ama":"Babic D, Abualia R, Fiedler L, et al. Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. Plant Journal. 2025;123(3). doi:10.1111/tpj.70396","mla":"Babic, David, et al. “Biosynthesis of Very Long-Chain Fatty Acids Is Required for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic Development.” Plant Journal, vol. 123, no. 3, e70396, Wiley, 2025, doi:10.1111/tpj.70396.","chicago":"Babic, David, Rashed Abualia, Lukas Fiedler, Linlin Qi, Frédérique Tellier, Adrijana Smoljan, Hana Rakusova, et al. “Biosynthesis of Very Long-Chain Fatty Acids Is Required for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic Development.” Plant Journal. Wiley, 2025. https://doi.org/10.1111/tpj.70396."},"has_accepted_license":"1","title":"Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development","related_material":{"record":[{"id":"20362","status":"public","relation":"dissertation_contains"}]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"acknowledgement":"We gratefully acknowledge the Imaging and Optics, Electron Microscopy (especially Vanessa Zheden for technical assistance) and Life Science (in particular Dorota Jaworska) facilities at ISTA for their continuous support. Authors would like to thank Michelle Gallei for advice during the generation of the transgenic lines; Zuzana Gelová for advice with DR5rev::GFP analyses; Ivan Kulich for help and advice on trichome imaging; Aline Monzer for generous help with hypocotyl and root analyses; Shutang Tan for help with the NGS data analysis; and Milan Župunski for advice on abiotic stress experiments. We would like to thank Dolf Weijers for the SOSEKI (SOK) marker line seeds. This work has benefited from the support of IJPB's Plant Observatory platforms P0-Chem.\r\n\r\nThis work was supported by Austrian Science Fund (FWF) (I 6123-B) and Science and Technology Department of Jiangxi Province (20223BCJ25037) to Huibin Han. The IJPB benefits from the support of Saclay Plant Sciences-SPS (ANR-17-EUR-0007).","scopus_import":"1","oa_version":"Published Version","isi":1,"OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","article_type":"original","corr_author":"1","_id":"20187","issue":"3","PlanS_conform":"1","language":[{"iso":"eng"}],"oa":1,"author":[{"last_name":"Babic","full_name":"Babic, David","id":"db566d23-f6e0-11ea-865d-e6f270e968e7","first_name":"David"},{"last_name":"Abualia","full_name":"Abualia, Rashed","orcid":"0000-0002-9357-9415","id":"4827E134-F248-11E8-B48F-1D18A9856A87","first_name":"Rashed"},{"first_name":"Lukas","last_name":"Fiedler","full_name":"Fiedler, Lukas","id":"7c417475-8972-11ed-ae7b-8b674ca26986"},{"first_name":"Linlin","last_name":"Qi","full_name":"Qi, Linlin","orcid":"0000-0001-5187-8401","id":"44B04502-A9ED-11E9-B6FC-583AE6697425"},{"full_name":"Tellier, Frédérique","last_name":"Tellier","first_name":"Frédérique"},{"id":"cced8a85-223e-11ed-af04-b0596c55053b","full_name":"Smoljan, Adrijana","last_name":"Smoljan","first_name":"Adrijana"},{"full_name":"Rakusova, Hana","last_name":"Rakusova","id":"4CAAA450-78D2-11EA-8E57-B40A396E08BA","first_name":"Hana"},{"first_name":"Petr","id":"3CDB6F94-F248-11E8-B48F-1D18A9856A87","last_name":"Valošek","full_name":"Valošek, Petr"},{"id":"31435098-F248-11E8-B48F-1D18A9856A87","full_name":"Han, Huibin","last_name":"Han","first_name":"Huibin"},{"first_name":"Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","full_name":"Benková, Eva","last_name":"Benková"},{"first_name":"Jean Denis","full_name":"Faure, Jean Denis","last_name":"Faure"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jiří"}],"type":"journal_article","day":"01","status":"public","OA_place":"publisher","quality_controlled":"1","month":"08","article_number":"e70396","publisher":"Wiley","publication_identifier":{"eissn":["1365-313X"],"issn":["0960-7412"]},"file_date_updated":"2025-09-01T14:09:31Z","intvolume":" 123","publication":"Plant Journal","file":[{"relation":"main_file","file_id":"20264","checksum":"1cdc3341d2d23101abca72521f1f23cb","success":1,"content_type":"application/pdf","date_created":"2025-09-01T14:09:31Z","creator":"dernst","file_size":5791111,"date_updated":"2025-09-01T14:09:31Z","file_name":"2025_PlantJournal_Babic.pdf","access_level":"open_access"}],"publication_status":"published","external_id":{"isi":["001547884300001"],"pmid":["40782342"]},"department":[{"_id":"EvBe"},{"_id":"JiFr"},{"_id":"GradSch"}],"abstract":[{"lang":"eng","text":"Very long-chain fatty acids (VLCFAs), being constituents of different types of lipids, are critical factors in plant development, presumably due to their impact on the endomembrane system. The VLCFAs are synthesized in the endoplasmic reticulum by a heterotetrameric enzymatic complex including β-ketoacyl CoA reductase 1 (KCR1), whose mutant is lethal. Here, we describe the ectopic shoot meristems (esm) mutant, a viable kcr1 allele presumably affecting surface properties of the KCR1 protein. This kcr1-2 mutant shows reduced fatty acyl elongation that impacts VLCFAs. The kcr1-2 plants show severe defects during different stages of development, which all correlate with defects in polar localization and subcellular trafficking of PIN auxin transporters and resulting asymmetric auxin distribution. Detailed analysis of KCR1 expression and patterning defects in kcr1-2 suggests that KCR1 plays a role in delineating boundaries around meristematic and specialized differentiating tissues, including root and shoot meristems, initiating lateral roots, lateral root primordia, and trichomes. In these contexts, KCR1-produced VLCFAs may act in a non-cell-autonomous manner. Viable kcr1-2 represents a useful tool to study VLCFA roles in plant development and highlights VLCFAs as critical developmental factors at the interface of cell polarity and tissue development."}],"doi":"10.1111/tpj.70396","ddc":["580"],"project":[{"name":"Peptide receptors for auxin canalization in Arabidopsis","grant_number":"I06123","_id":"bd76d395-d553-11ed-ba76-f678c14f9033"}],"date_published":"2025-08-01T00:00:00Z","volume":123,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_updated":"2026-04-07T11:52:02Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","year":"2025","date_created":"2025-08-17T22:01:36Z"},{"title":"Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration","acknowledgement":"We are grateful to the members of the Matsuda Laboratory for their helpful input, to K. Hirano, T. Uesugi and K. Takakura, who provided technical assistance, and to the Medical Research Support Center of Kyoto University for DNA sequence analysis. This work was supported by the Kyoto University Live Imaging Center. Financial support was provided by Japan Society for the Promotion of Science (JSPS) KAKENHI grants (21H05226 to K.T., 19H00993 and 20H05898 to M.M.), a Japan Science and Technology Agency (JST) CREST grant (JPMJCR1654 to M.M.), and a JST Moonshot Research and Development Program grant (JPMJPS2022 to M.M.). Open Access funding provided by Tokushima University. Deposited in PMC for immediate release.","oa_version":"Published Version","scopus_import":"1","OA_type":"hybrid","isi":1,"pmid":1,"citation":{"mla":"Jikko, Yuya, et al. “Front-Biased Activation of the Ras-Rab5-Rac1 Loop Coordinates Collective Cell Migration.” Journal of Cell Science, vol. 138, no. 15, 263779, The Company of Biologists, 2025, doi:10.1242/jcs.263779.","chicago":"Jikko, Yuya, Eriko Deguchi, Kimiya Matsuda, Naoya Hino, Shinya Tsukiji, Michiyuki Matsuda, and Kenta Terai. “Front-Biased Activation of the Ras-Rab5-Rac1 Loop Coordinates Collective Cell Migration.” Journal of Cell Science. The Company of Biologists, 2025. https://doi.org/10.1242/jcs.263779.","short":"Y. Jikko, E. Deguchi, K. Matsuda, N. Hino, S. Tsukiji, M. Matsuda, K. Terai, Journal of Cell Science 138 (2025).","ieee":"Y. Jikko et al., “Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration,” Journal of Cell Science, vol. 138, no. 15. The Company of Biologists, 2025.","ama":"Jikko Y, Deguchi E, Matsuda K, et al. Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. Journal of Cell Science. 2025;138(15). doi:10.1242/jcs.263779","ista":"Jikko Y, Deguchi E, Matsuda K, Hino N, Tsukiji S, Matsuda M, Terai K. 2025. Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. Journal of Cell Science. 138(15), 263779.","apa":"Jikko, Y., Deguchi, E., Matsuda, K., Hino, N., Tsukiji, S., Matsuda, M., & Terai, K. (2025). Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. Journal of Cell Science. The Company of Biologists. https://doi.org/10.1242/jcs.263779"},"has_accepted_license":"1","day":"01","type":"journal_article","OA_place":"publisher","status":"public","quality_controlled":"1","month":"08","publisher":"The Company of Biologists","publication_identifier":{"issn":[" 0021-9533"],"eissn":["1477-9137"]},"article_number":"263779","article_type":"original","article_processing_charge":"Yes (via OA deal)","PlanS_conform":"1","issue":"15","_id":"20188","language":[{"iso":"eng"}],"oa":1,"author":[{"full_name":"Jikko, Yuya","last_name":"Jikko","first_name":"Yuya"},{"last_name":"Deguchi","full_name":"Deguchi, Eriko","first_name":"Eriko"},{"full_name":"Matsuda, Kimiya","last_name":"Matsuda","first_name":"Kimiya"},{"full_name":"Hino, Naoya","last_name":"Hino","id":"5299a9ce-7679-11eb-a7bc-d1e62b936307","first_name":"Naoya"},{"first_name":"Shinya","last_name":"Tsukiji","full_name":"Tsukiji, Shinya"},{"first_name":"Michiyuki","last_name":"Matsuda","full_name":"Matsuda, Michiyuki"},{"full_name":"Terai, Kenta","last_name":"Terai","first_name":"Kenta"}],"publication_status":"published","department":[{"_id":"CaHe"}],"external_id":{"isi":["001567723900009"],"pmid":["40667649"]},"abstract":[{"text":"Collective cell migration is coordinated by the front-to-rear intercellular propagation of EGFR-Ras-ERK pathway activation. However, the molecular mechanisms integrating front-to-rear information into this intercellular signaling cascade, particularly the determinants of cellular front-side specification, remain elusive. We visualized the activity of EGFR, Ras, Rac1 and Rab5A (hereafter Rab5) by using FRET biosensors and chemogenetic tools. Whereas EGFR activation was uniformly observed within cells, Ras activation was biased to the front side within cells. The polarized Ras activation depended on Merlin and Rac1, which also showed front-biased activation. Furthermore, Rab5, a crucial regulator of cell migration, demonstrated similar front-biased activation and was found to function downstream of Ras while being necessary for Rac1 activation. Thus, the positive feedback loop consisting of Ras, Rab5 and Rac1 is activated primarily at the front of collectively migrating cells. These findings offer new spatio-temporal insight into processing front–rear information during collective cell migration.","lang":"eng"}],"doi":"10.1242/jcs.263779","file_date_updated":"2025-09-01T10:02:24Z","file":[{"date_created":"2025-09-01T10:02:24Z","content_type":"application/pdf","success":1,"checksum":"29f42619dab5ce251a20c769ed4581c0","file_id":"20262","relation":"main_file","access_level":"open_access","date_updated":"2025-09-01T10:02:24Z","file_size":12393297,"file_name":"2025_JourCellScience_Jikko.pdf","creator":"dernst"}],"publication":"Journal of Cell Science","intvolume":" 138","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2025","date_created":"2025-08-17T22:01:36Z","date_published":"2025-08-01T00:00:00Z","ddc":["570"],"date_updated":"2025-11-27T14:12:24Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":138},{"author":[{"first_name":"Nils","last_name":"Froleyks","full_name":"Froleyks, Nils"},{"first_name":"Zhengqi","last_name":"Yu","full_name":"Yu, Zhengqi","orcid":"0000-0002-4993-773X","id":"20aa2ae8-f2f1-11ed-bbfa-8205053f1342"},{"first_name":"Mathias","full_name":"Preiner, Mathias","last_name":"Preiner"},{"first_name":"Armin","last_name":"Biere","full_name":"Biere, Armin"},{"first_name":"Keijo","full_name":"Heljanko, Keijo","last_name":"Heljanko"}],"oa":1,"language":[{"iso":"eng"}],"_id":"20189","article_processing_charge":"Yes (in subscription journal)","publication_identifier":{"eissn":["1611-3349"],"issn":["0302-9743"],"isbn":["9783031986673"]},"publisher":"Springer Nature","quality_controlled":"1","month":"01","page":"281-295","status":"public","OA_place":"publisher","type":"conference","day":"01","has_accepted_license":"1","citation":{"ista":"Froleyks N, Yu E, Preiner M, Biere A, Heljanko K. 2025. Introducing certificates to the hardware model checking competition. 37th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 15931, 281–295.","apa":"Froleyks, N., Yu, E., Preiner, M., Biere, A., & Heljanko, K. (2025). Introducing certificates to the hardware model checking competition. In 37th International Conference on Computer Aided Verification (Vol. 15931, pp. 281–295). Zagreb, Croatia: Springer Nature. https://doi.org/10.1007/978-3-031-98668-0_14","ieee":"N. Froleyks, E. Yu, M. Preiner, A. Biere, and K. Heljanko, “Introducing certificates to the hardware model checking competition,” in 37th International Conference on Computer Aided Verification, Zagreb, Croatia, 2025, vol. 15931, pp. 281–295.","ama":"Froleyks N, Yu E, Preiner M, Biere A, Heljanko K. Introducing certificates to the hardware model checking competition. In: 37th International Conference on Computer Aided Verification. Vol 15931. Springer Nature; 2025:281-295. doi:10.1007/978-3-031-98668-0_14","short":"N. Froleyks, E. Yu, M. Preiner, A. Biere, K. Heljanko, in:, 37th International Conference on Computer Aided Verification, Springer Nature, 2025, pp. 281–295.","mla":"Froleyks, Nils, et al. “Introducing Certificates to the Hardware Model Checking Competition.” 37th International Conference on Computer Aided Verification, vol. 15931, Springer Nature, 2025, pp. 281–95, doi:10.1007/978-3-031-98668-0_14.","chicago":"Froleyks, Nils, Emily Yu, Mathias Preiner, Armin Biere, and Keijo Heljanko. “Introducing Certificates to the Hardware Model Checking Competition.” In 37th International Conference on Computer Aided Verification, 15931:281–95. Springer Nature, 2025. https://doi.org/10.1007/978-3-031-98668-0_14."},"OA_type":"hybrid","isi":1,"scopus_import":"1","acknowledgement":"This work is supported in part by the ERC-2020-AdG 101020093, the LIT AI Lab funded by the State of Upper Austria, the Research Council of Finland under the project 336092, and a gift from Intel Corporation.\r\nFurthermore we of course also owe a big thank-you to the submitters of model checkers and benchmarks to the competition over all these years. Without their enthusiasm and support neither the competition nor this study would exist.","oa_version":"Published Version","title":"Introducing certificates to the hardware model checking competition","conference":{"end_date":"2025-07-25","name":"CAV: Computer Aided Verification","start_date":"2025-07-23","location":"Zagreb, Croatia"},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":15931,"date_updated":"2025-12-01T12:34:05Z","ddc":["000"],"project":[{"name":"Vigilant Algorithmic Monitoring of Software","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","grant_number":"101020093","call_identifier":"H2020"}],"date_published":"2025-01-01T00:00:00Z","date_created":"2025-08-17T22:01:36Z","year":"2025","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 15931","file":[{"access_level":"open_access","file_name":"2025_CAV_Froleyks.pdf","file_size":1078274,"date_updated":"2025-09-02T05:46:10Z","creator":"dernst","date_created":"2025-09-02T05:46:10Z","content_type":"application/pdf","success":1,"checksum":"15ec1bc9b9409d3b2736f4c9d5f42fd1","file_id":"20266","relation":"main_file"}],"publication":"37th International Conference on Computer Aided Verification","file_date_updated":"2025-09-02T05:46:10Z","alternative_title":["LNCS"],"doi":"10.1007/978-3-031-98668-0_14","abstract":[{"lang":"eng","text":"Certification was made mandatory for the first time in the latest hardware model checking competition. In this case study, we investigate the trade-offs of requiring certificates for both passing and failing properties in the competition. Our evaluation shows that participating model checkers were able to produce compact, correct certificates that could be verified with minimal overhead. Furthermore, the certifying winner of the competition outperforms the previous non-certifying state-of-the-art model checker, demonstrating that certification can be adopted without compromising model checking efficiency."}],"ec_funded":1,"external_id":{"isi":["001562507100014"]},"department":[{"_id":"ToHe"}],"publication_status":"published"},{"date_updated":"2025-09-30T14:29:33Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":8,"date_published":"2025-07-25T00:00:00Z","ddc":["520"],"date_created":"2025-08-17T22:01:37Z","year":"2025","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"relation":"main_file","checksum":"ba469d132907147f9e86d87f9124dd14","file_id":"20412","success":1,"content_type":"application/pdf","date_created":"2025-09-30T14:28:25Z","creator":"dernst","date_updated":"2025-09-30T14:28:25Z","file_size":1836432,"file_name":"2025_OpenJourAstrophysics_Katz.pdf","access_level":"open_access"}],"publication":"The Open Journal of Astrophysics","intvolume":" 8","file_date_updated":"2025-09-30T14:28:25Z","doi":"10.33232/001c.142570","abstract":[{"text":"We study the physical origin and spectroscopic impact of extreme nebular emission in high-redshift galaxies. The nebular continuum, which can appear during an extreme starburst, is of particular importance as it tends to redden UV slopes and has a significant contribution to the UV luminosities of galaxies. Furthermore, its shape can be used to infer the gas density and temperature of the interstellar medium. First, we provide a theoretical background, showing how different stellar populations (SPS models, initial mass functions (IMFs), and stellar temperatures) and nebular conditions impact observed galaxy spectra. We demonstrate that, for systems with strong nebular continuum emission, 1) UV fluxes can increase by up to 0.7~mag (or more in the case of hot/massive stars) above the stellar continuum, which may help reconcile the surprising abundance of bright high-redshift galaxies and the elevated UV luminosity density at z>10, 2) at high gas densities, UV slopes can redden from \\beta<-2.5 to \\beta\\sim-1, 3) observational measurements of \\xi_{\\rm ion} are gross underestimates, and 4) UV downturns from two-photon emission can masquerade as damped Ly\\alpha systems. Second, we present a dataset of 58 galaxies observed with NIRSpec on JWST at 2.510 galaxies, finding that UV slopes and UV downturns are in some cases redder or steeper than expected from SPS models, which may hint at more exotic (e.g. hotter/more massive stars or AGN) ionizing sources.","lang":"eng"}],"department":[{"_id":"JoMa"}],"external_id":{"arxiv":["2408.03189"]},"publication_status":"published","author":[{"first_name":"Harley","last_name":"Katz","full_name":"Katz, Harley"},{"first_name":"Alex J.","full_name":"Cameron, Alex J.","last_name":"Cameron"},{"full_name":"Saxena, Aayush","last_name":"Saxena","first_name":"Aayush"},{"last_name":"Barrufet","full_name":"Barrufet, Laia","first_name":"Laia"},{"full_name":"Choustikov, Nicholas","last_name":"Choustikov","first_name":"Nicholas"},{"first_name":"Nikko J.","last_name":"Cleri","full_name":"Cleri, Nikko J."},{"last_name":"De Graaff","full_name":"De Graaff, Anna","first_name":"Anna"},{"first_name":"Richard S.","last_name":"Ellis","full_name":"Ellis, Richard S."},{"last_name":"Fosbury","full_name":"Fosbury, Robert A.E.","first_name":"Robert A.E."},{"first_name":"Kasper E.","full_name":"Heintz, Kasper E.","last_name":"Heintz"},{"first_name":"Michael","full_name":"Maseda, Michael","last_name":"Maseda"},{"first_name":"Jorryt J","full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","last_name":"Matthee","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"last_name":"Mcconachie","full_name":"Mcconachie, Ian","first_name":"Ian"},{"first_name":"Pascal A.","last_name":"Oesch","full_name":"Oesch, Pascal A."}],"language":[{"iso":"eng"}],"oa":1,"PlanS_conform":"1","_id":"20192","article_processing_charge":"No","article_type":"original","publication_identifier":{"eissn":["2565-6120"]},"publisher":"Maynooth Academic Publishing","month":"07","quality_controlled":"1","OA_place":"publisher","status":"public","day":"25","type":"journal_article","has_accepted_license":"1","arxiv":1,"citation":{"chicago":"Katz, Harley, Alex J. Cameron, Aayush Saxena, Laia Barrufet, Nicholas Choustikov, Nikko J. Cleri, Anna De Graaff, et al. “21 Balmer Jump Street: The Nebular Continuum at High Redshift and Implications for the Bright Galaxy Problem, UV Continuum Slopes, and Early Stellar Populations.” The Open Journal of Astrophysics. Maynooth Academic Publishing, 2025. https://doi.org/10.33232/001c.142570.","mla":"Katz, Harley, et al. “21 Balmer Jump Street: The Nebular Continuum at High Redshift and Implications for the Bright Galaxy Problem, UV Continuum Slopes, and Early Stellar Populations.” The Open Journal of Astrophysics, vol. 8, Maynooth Academic Publishing, 2025, doi:10.33232/001c.142570.","apa":"Katz, H., Cameron, A. J., Saxena, A., Barrufet, L., Choustikov, N., Cleri, N. J., … Oesch, P. A. (2025). 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. The Open Journal of Astrophysics. Maynooth Academic Publishing. https://doi.org/10.33232/001c.142570","ista":"Katz H, Cameron AJ, Saxena A, Barrufet L, Choustikov N, Cleri NJ, De Graaff A, Ellis RS, Fosbury RAE, Heintz KE, Maseda M, Matthee JJ, Mcconachie I, Oesch PA. 2025. 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. The Open Journal of Astrophysics. 8.","ama":"Katz H, Cameron AJ, Saxena A, et al. 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. The Open Journal of Astrophysics. 2025;8. doi:10.33232/001c.142570","ieee":"H. Katz et al., “21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations,” The Open Journal of Astrophysics, vol. 8. Maynooth Academic Publishing, 2025.","short":"H. Katz, A.J. Cameron, A. Saxena, L. Barrufet, N. Choustikov, N.J. Cleri, A. De Graaff, R.S. Ellis, R.A.E. Fosbury, K.E. Heintz, M. Maseda, J.J. Matthee, I. Mcconachie, P.A. Oesch, The Open Journal of Astrophysics 8 (2025)."},"OA_type":"diamond","scopus_import":"1","acknowledgement":"HK thanks Andrey Kravtsov for insightful comments and thoughtful discussions. We sincerely thank the PIs and Co-Is of the JWST programs where spectral data was made publicly available on the DJA. We refer interested readers to the following papers for survey descriptions regarding the spectral data: Bunker et al. (2023a); D’Eugenio et al. (2024); Bezanson et al. (2022); Barrufet et al. (2024); de Graaff et al. (2024); Finkelstein et al. (2024); Glazebrook et al. (2024); Pierel et al. (2024); Siebert et al. (2024); Maseda et al. (2024). This work is based in part on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs listed in Table 1. AJC and AS acknowledge funding from the “FirstGalaxies” Advanced Grant from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 789056). ","oa_version":"Published Version","title":"21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations"},{"oa_version":"Preprint","acknowledgement":"We thank A. C. Carnall for supporting our use of Bagpipes. We thank Y. Fu for his help on the use of QSOFitMORE. We thank J. Greene, S. Toft, T. Kakimoto and M. Tanaka for fruitful discussions. This work is based on observations made with the NASA/ESA/CSA JWST. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, under NASA contract NAS 5-03127 for JWST. These observations are associated with programmes GO 1967 and GO 3859. Support for these programmes was provided by NASA through a grant from the Space Telescope Science Institute. This work was supported by World Premier International Research Center Initiative, MEXT, Japan. This work used computing resources at Kavli IPMU. M.O., X.D., J.D.S., Y.M., T.I., K. Ito, K.K. and H.U. are supported by the Japan Society for the Promotion of Science (KAKENHI Grant Numbers JP24K22894, JP22K14071, JP18H01251, JP22H01262, JP21H04494, JP20K14531, JP23K13141, JP17H06130 and JP20H01953). M.O. and K. Inayoshi acknowledge support from the National Natural Science Foundation of China (Grant Numbers 12150410307, 12073003, 11721303, 11991052 and 11950410493). K. Inayoshi acknowledges support from the China Manned Space Project (Grant Numbers CMS-CSST-2021-A04 and CMS-CSST-2021-A06). S.E.I.B. is funded by the Deutsche Forschungsgemeinschaft (German Research Foundation) under Emmy Noether Grant Number BO 5771/1-1. Z.H., T.T. and M.S. acknowledge support from the NSF (Grant Numbers AST-2006176, AST-1907208 and AST-2006177). A.L. acknowledges funding from MUR (Grant Number PRIN 2022935STW). B.T. acknowledges support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement Number 950533) and from the Israel Science Foundation (Grant Number 1849/19). F. Walter acknowledges support from the ERC (Grant Cosmic_gas). J.-T.S. is supported by the Deutsche Forschungsgemeinschaft (Project Number 518006966). M.T. acknowledges support from the NWO (Grant Number 0.16.VIDI.189.162, ODIN). S.F. acknowledges support from NASA through the NASA Hubble Fellowship (Grant Number HST-HF2-51505.001-A awarded by the Space Telescope Science Institute). K. Iwasawa acknowledges support under Grant Number PID2022-136827NB-C44 funded by MCIN/AEI/10.13039/501100011033 /FEDER, EU. M. Vestergaard gratefully acknowledges financial support from the Independent Research Fund Denmark (Grant Numbers DFF 8021-00130 and 3103-00146). F. Wang acknowledges support from the NSF (Award Number AST-2513040). R.B. is supported by the SNSF through the Ambizione Grant PZ00P2_223532.","scopus_import":"1","OA_type":"green","isi":1,"title":"A post-starburst pathway for the formation of massive galaxies and black holes at z > 6","citation":{"chicago":"Onoue, Masafusa, Xuheng Ding, John D. Silverman, Yoshiki Matsuoka, Takuma Izumi, Michael A. Strauss, Charlotte Ward, et al. “A Post-Starburst Pathway for the Formation of Massive Galaxies and Black Holes at z > 6.” Nature Astronomy. Springer Nature, 2025. https://doi.org/10.1038/s41550-025-02628-1.","mla":"Onoue, Masafusa, et al. “A Post-Starburst Pathway for the Formation of Massive Galaxies and Black Holes at z > 6.” Nature Astronomy, vol. 9, Springer Nature, 2025, pp. 1541–52, doi:10.1038/s41550-025-02628-1.","ama":"Onoue M, Ding X, Silverman JD, et al. A post-starburst pathway for the formation of massive galaxies and black holes at z > 6. Nature Astronomy. 2025;9:1541-1552. doi:10.1038/s41550-025-02628-1","short":"M. Onoue, X. Ding, J.D. Silverman, Y. Matsuoka, T. Izumi, M.A. Strauss, C. Ward, C.L. Phillips, K. Ito, I.T. Andika, K. Aoki, J. Arita, S. Baba, R. Bieri, S.E.I. Bosman, A.C. Eilers, S. Fujimoto, M. Habouzit, Z. Haiman, M. Imanishi, K. Inayoshi, K. Iwasawa, K. Jahnke, N. Kashikawa, T. Kawaguchi, K. Kohno, C.H. Lee, J. Li, A. Lupi, J. Lyu, T. Nagao, R. Overzier, J.T. Schindler, M. Schramm, M.T. Scoggins, K. Shimasaku, Y. Toba, B. Trakhtenbrot, M. Trebitsch, T. Treu, H. Umehata, B. Venemans, M. Vestergaard, M. Volonteri, F. Walter, F. Wang, J. Yang, H. Zhang, Nature Astronomy 9 (2025) 1541–1552.","ieee":"M. Onoue et al., “A post-starburst pathway for the formation of massive galaxies and black holes at z > 6,” Nature Astronomy, vol. 9. Springer Nature, pp. 1541–1552, 2025.","ista":"Onoue M, Ding X, Silverman JD, Matsuoka Y, Izumi T, Strauss MA, Ward C, Phillips CL, Ito K, Andika IT, Aoki K, Arita J, Baba S, Bieri R, Bosman SEI, Eilers AC, Fujimoto S, Habouzit M, Haiman Z, Imanishi M, Inayoshi K, Iwasawa K, Jahnke K, Kashikawa N, Kawaguchi T, Kohno K, Lee CH, Li J, Lupi A, Lyu J, Nagao T, Overzier R, Schindler JT, Schramm M, Scoggins MT, Shimasaku K, Toba Y, Trakhtenbrot B, Trebitsch M, Treu T, Umehata H, Venemans B, Vestergaard M, Volonteri M, Walter F, Wang F, Yang J, Zhang H. 2025. A post-starburst pathway for the formation of massive galaxies and black holes at z > 6. Nature Astronomy. 9, 1541–1552.","apa":"Onoue, M., Ding, X., Silverman, J. D., Matsuoka, Y., Izumi, T., Strauss, M. A., … Zhang, H. (2025). A post-starburst pathway for the formation of massive galaxies and black holes at z > 6. Nature Astronomy. Springer Nature. https://doi.org/10.1038/s41550-025-02628-1"},"arxiv":1,"month":"10","quality_controlled":"1","publisher":"Springer Nature","publication_identifier":{"eissn":["2397-3366"]},"type":"journal_article","day":"01","status":"public","page":"1541-1552","OA_place":"repository","language":[{"iso":"eng"}],"oa":1,"author":[{"first_name":"Masafusa","full_name":"Onoue, Masafusa","last_name":"Onoue"},{"first_name":"Xuheng","last_name":"Ding","full_name":"Ding, Xuheng"},{"first_name":"John D.","full_name":"Silverman, John D.","last_name":"Silverman"},{"first_name":"Yoshiki","full_name":"Matsuoka, Yoshiki","last_name":"Matsuoka"},{"first_name":"Takuma","full_name":"Izumi, Takuma","last_name":"Izumi"},{"first_name":"Michael A.","last_name":"Strauss","full_name":"Strauss, Michael A."},{"first_name":"Charlotte","last_name":"Ward","full_name":"Ward, Charlotte"},{"last_name":"Phillips","full_name":"Phillips, Camryn L.","first_name":"Camryn L."},{"first_name":"Kei","last_name":"Ito","full_name":"Ito, Kei"},{"first_name":"Irham T.","full_name":"Andika, Irham T.","last_name":"Andika"},{"first_name":"Kentaro","last_name":"Aoki","full_name":"Aoki, Kentaro"},{"full_name":"Arita, Junya","last_name":"Arita","first_name":"Junya"},{"first_name":"Shunsuke","full_name":"Baba, Shunsuke","last_name":"Baba"},{"first_name":"Rebekka","full_name":"Bieri, Rebekka","last_name":"Bieri"},{"full_name":"Bosman, Sarah E.I.","last_name":"Bosman","first_name":"Sarah E.I."},{"first_name":"Anna Christina","last_name":"Eilers","full_name":"Eilers, Anna Christina"},{"last_name":"Fujimoto","full_name":"Fujimoto, Seiji","first_name":"Seiji"},{"full_name":"Habouzit, Melanie","last_name":"Habouzit","first_name":"Melanie"},{"first_name":"Zoltán","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","last_name":"Haiman","full_name":"Haiman, Zoltán","orcid":"0000-0003-3633-5403"},{"last_name":"Imanishi","full_name":"Imanishi, Masatoshi","first_name":"Masatoshi"},{"first_name":"Kohei","full_name":"Inayoshi, Kohei","last_name":"Inayoshi"},{"first_name":"Kazushi","last_name":"Iwasawa","full_name":"Iwasawa, Kazushi"},{"full_name":"Jahnke, Knud","last_name":"Jahnke","first_name":"Knud"},{"full_name":"Kashikawa, Nobunari","last_name":"Kashikawa","first_name":"Nobunari"},{"full_name":"Kawaguchi, Toshihiro","last_name":"Kawaguchi","first_name":"Toshihiro"},{"last_name":"Kohno","full_name":"Kohno, Kotaro","first_name":"Kotaro"},{"first_name":"Chien Hsiu","full_name":"Lee, Chien Hsiu","last_name":"Lee"},{"full_name":"Li, Junyao","last_name":"Li","first_name":"Junyao"},{"last_name":"Lupi","full_name":"Lupi, Alessandro","first_name":"Alessandro"},{"first_name":"Jianwei","last_name":"Lyu","full_name":"Lyu, Jianwei"},{"first_name":"Tohru","last_name":"Nagao","full_name":"Nagao, Tohru"},{"full_name":"Overzier, Roderik","last_name":"Overzier","first_name":"Roderik"},{"full_name":"Schindler, Jan Torge","last_name":"Schindler","first_name":"Jan Torge"},{"last_name":"Schramm","full_name":"Schramm, Malte","first_name":"Malte"},{"first_name":"Matthew T.","full_name":"Scoggins, Matthew T.","last_name":"Scoggins"},{"first_name":"Kazuhiro","last_name":"Shimasaku","full_name":"Shimasaku, Kazuhiro"},{"full_name":"Toba, Yoshiki","last_name":"Toba","first_name":"Yoshiki"},{"first_name":"Benny","full_name":"Trakhtenbrot, Benny","last_name":"Trakhtenbrot"},{"first_name":"Maxime","last_name":"Trebitsch","full_name":"Trebitsch, Maxime"},{"last_name":"Treu","full_name":"Treu, Tommaso","first_name":"Tommaso"},{"first_name":"Hideki","full_name":"Umehata, Hideki","last_name":"Umehata"},{"first_name":"Bram","last_name":"Venemans","full_name":"Venemans, Bram"},{"full_name":"Vestergaard, Marianne","last_name":"Vestergaard","first_name":"Marianne"},{"full_name":"Volonteri, Marta","last_name":"Volonteri","first_name":"Marta"},{"first_name":"Fabian","full_name":"Walter, Fabian","last_name":"Walter"},{"first_name":"Feige","last_name":"Wang","full_name":"Wang, Feige"},{"last_name":"Yang","full_name":"Yang, Jinyi","first_name":"Jinyi"},{"first_name":"Haowen","last_name":"Zhang","full_name":"Zhang, Haowen"}],"article_type":"original","article_processing_charge":"No","_id":"20193","abstract":[{"lang":"eng","text":"Understanding the rapid formation of supermassive black holes in the early Universe requires insights into stellar mass growth in host galaxies. Here we present NIRSpec rest-frame optical spectra and NIRCam imaging from JWST of two galaxies at z > 6, both hosting moderate-luminosity quasars. These galaxies exhibit Balmer absorption lines, like low-redshift post-starburst galaxies. Our analyses of the medium-resolution spectra and multiband photometry show that the bulk of the stellar mass (log(M*/M☉) ≥ 10.6) formed in starburst episodes at redshift 9 and 7. One of the galaxies shows a clear Balmer break and lacks spatially resolved Hα emission. It falls well below the star-formation main sequence at z = 6, indicating quiescence. The other is transitioning to quiescence; together, these massive galaxies are among the most distant post-starburst systems known. The blueshifted wings of the quasar [O iii] emission lines indicate quasar-driven outflow, which possibly influences star formation. Direct stellar velocity dispersion measurements reveal that one galaxy follows the local black hole mass versus σ* relation whereas the other is overmassive. The existence of massive post-starburst galaxies hosting billion-solar-mass black holes in short-lived quasar phases indicates that supermassive black holes and host galaxies played a principal role in each other’s rapid early formation."}],"doi":"10.1038/s41550-025-02628-1","publication_status":"published","external_id":{"isi":["001548138600001"],"arxiv":["2409.07113"]},"department":[{"_id":"ZoHa"}],"intvolume":" 9","publication":"Nature Astronomy","year":"2025","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2409.07113"}],"date_created":"2025-08-17T22:01:38Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":9,"date_updated":"2025-12-30T13:08:12Z","date_published":"2025-10-01T00:00:00Z"},{"language":[{"iso":"eng"}],"oa":1,"supervisor":[{"first_name":"Johann G","last_name":"Danzl","orcid":"0000-0001-8559-3973","full_name":"Danzl, Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87"}],"author":[{"orcid":"0009-0000-7590-3501","full_name":"Vorlaufer, Jakob","last_name":"Vorlaufer","id":"937696FA-C996-11E9-8C7C-CF13E6697425","first_name":"Jakob"}],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","article_processing_charge":"No","corr_author":"1","_id":"20206","month":"08","publication_identifier":{"issn":["2663-337X"]},"publisher":"Institute of Science and Technology Austria","type":"dissertation","day":"25","page":"107","status":"public","OA_place":"publisher","citation":{"ieee":"J. Vorlaufer, “Construction of a cryo-super-resolution microscope to guide in situ structure analysis,” Institute of Science and Technology Austria, 2025.","short":"J. Vorlaufer, Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis, Institute of Science and Technology Austria, 2025.","ama":"Vorlaufer J. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. 2025. doi:10.15479/AT-ISTA-20206","ista":"Vorlaufer J. 2025. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. Institute of Science and Technology Austria.","apa":"Vorlaufer, J. (2025). Construction of a cryo-super-resolution microscope to guide in situ structure analysis. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20206","mla":"Vorlaufer, Jakob. Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20206.","chicago":"Vorlaufer, Jakob. “Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20206."},"has_accepted_license":"1","oa_version":"Published Version","acknowledgement":"The project was supported by CZI grant DAF2021-234754 and grant\r\nDOI: https://doi.org/10.37921/812628ebpcwg from the Chan Zuckerberg Initiative DAF, an\r\nadvised fund of Silicon Valley Community Foundation (funder\r\nDOI: https://doi.org/10.13039/100014989), as well as internal grants from ISTA’s Equipment\r\nInvestment Committee and Interdisciplinary Project Committee. ","title":"Construction of a cryo-super-resolution microscope to guide in situ structure analysis","related_material":{"record":[{"id":"19795","status":"public","relation":"part_of_dissertation"}]},"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"EM-Fac"},{"_id":"Bio"}],"tmp":{"image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"date_updated":"2026-04-07T11:48:07Z","project":[{"name":"CryoMinflux-guided in-situ molecular census and structure determination","grant_number":"CZI01","_id":"62909c6f-2b32-11ec-9570-e1476aab5308"}],"ddc":["621","535"],"date_published":"2025-08-25T00:00:00Z","year":"2025","date_created":"2025-08-22T08:12:55Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","file":[{"checksum":"191db3367c19c9b32b65f4bc3a7c19de","file_id":"20228","relation":"source_file","date_created":"2025-08-25T13:49:55Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","creator":"jvorlauf","access_level":"closed","date_updated":"2025-08-25T13:49:55Z","file_name":"2025_Vorlaufer_Jakob_Thesis.docx","file_size":39735535},{"creator":"jvorlauf","file_size":10947446,"date_updated":"2025-08-25T13:49:56Z","file_name":"2025_Vorlaufer_Jakob_Thesis.pdf","access_level":"open_access","relation":"main_file","file_id":"20229","checksum":"104400e6036921569610230c1d4899dc","content_type":"application/pdf","success":1,"date_created":"2025-08-25T13:49:56Z"}],"file_date_updated":"2025-08-25T13:49:56Z","abstract":[{"text":"The internal structure of biomolecules and their organization in higher-order arrangements are key factors governing the working principles of biological systems. Bioimaging has successfully revealed arrangements across relevant spatial scales. For example, cryo-electron tomography has become widely used for analyzing biomolecular structures in situ due to its comprehensive structural visualization of near-natively preserved samples, and its capability of sub-nm resolution via averaging. However, the identification of molecules within crowded cellular environments is often hindered by low contrast. Fluorescence microscopy, on the other hand, routinely visualizes specifically labeled targets at single-molecule contrast against essentially zero background. Moreover, it provides comparatively high throughput and is amenable to multiplexing. Due to this complementarity, combining datasets from both modalities acquired on the same region via correlative light and electron microscopy can reveal novel types of information. \r\nThe spatial scale at which information can be extracted depends on imaging resolution and correlation accuracy. Since diffraction of light limits the resolution of conventional fluorescence microscopy to few hundreds of nanometers, reaching the full potential of correlative imaging requires super-resolution approaches. Performing imaging at cryogenic temperature preserves structures in a near-native state and minimizes distortions between the fluorescence and the electron microscopy datasets. Implementations of this concept have achieved correlation on the scale of cellular organelles or bacterial domains.\r\nWe have worked towards pushing correlative imaging to the single-molecule scale by improving cryo-super-resolution microscopy, and devising a refined image correlation workflow. As part of this project, I constructed a microscopy setup and adopted it for super-resolution fluorescence microscopy at room temperature and cryogenic conditions. I explored different cryo-stages and acquisition strategies. Specifically, I developed a new scheme for correcting sample drift, thus increasing mechanical stability during microscopy acquisitions.\r\n","lang":"eng"}],"alternative_title":["ISTA Thesis"],"doi":"10.15479/AT-ISTA-20206","degree_awarded":"PhD","publication_status":"published","department":[{"_id":"GradSch"},{"_id":"JoDa"}]},{"date_updated":"2026-04-14T08:16:57Z","date_published":"2025-08-22T00:00:00Z","project":[{"grant_number":"26253","_id":"34c9fbcb-11ca-11ed-8bc3-98fa5658610d","name":"Molecular Mechanisms Regulating Cortical Neural Stem Cell Lineage Progression and Astrocyte Development"}],"ddc":["570"],"year":"2025","date_created":"2025-08-22T14:07:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","file":[{"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2025-08-26T09:03:50Z","relation":"source_file","checksum":"3331f76bbef74ff4908e2d2c9262045c","file_id":"20230","file_size":32887334,"date_updated":"2025-08-26T09:03:50Z","file_name":"2025_MirandaRomero_OsvaldoAntonio_Thesis.docx","access_level":"closed","creator":"omiranda"},{"embargo_to":"open_access","access_level":"closed","file_name":"2025_MirandaRomero_OsvaldoAntonio_Thesis.pdf","file_size":28636240,"date_updated":"2025-08-26T10:43:30Z","embargo":"2026-08-26","creator":"omiranda","date_created":"2025-08-26T09:05:55Z","content_type":"application/pdf","checksum":"02509d50cff8e35c5bcbf71e8d658176","file_id":"20231","relation":"main_file"}],"file_date_updated":"2025-08-26T10:43:30Z","degree_awarded":"PhD","doi":"10.15479/AT-ISTA-20212","alternative_title":["ISTA Thesis"],"publication_status":"published","department":[{"_id":"GradSch"},{"_id":"SiHi"}],"language":[{"iso":"eng"}],"supervisor":[{"first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer"}],"author":[{"first_name":"Osvaldo","id":"862A3C56-A8BF-11E9-B4FA-D9E3E5697425","last_name":"Miranda","full_name":"Miranda, Osvaldo","orcid":"0000-0001-6618-6889"}],"article_processing_charge":"No","corr_author":"1","_id":"20212","keyword":["Pten","mtor","cortical development","MADM","Mapk"],"month":"08","publisher":"Institute of Science and Technology Austria","publication_identifier":{"isbn":["978-3-99078-063-3"],"issn":["2663-337X"]},"day":"22","type":"dissertation","OA_place":"publisher","status":"public","page":"119","citation":{"ista":"Miranda O. 2025. Unraveling the role of Pten in cortical stem cell lineage progression using MADM. Institute of Science and Technology Austria.","apa":"Miranda, O. (2025). Unraveling the role of Pten in cortical stem cell lineage progression using MADM. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20212","ama":"Miranda O. Unraveling the role of Pten in cortical stem cell lineage progression using MADM. 2025. doi:10.15479/AT-ISTA-20212","ieee":"O. Miranda, “Unraveling the role of Pten in cortical stem cell lineage progression using MADM,” Institute of Science and Technology Austria, 2025.","short":"O. Miranda, Unraveling the Role of Pten in Cortical Stem Cell Lineage Progression Using MADM, Institute of Science and Technology Austria, 2025.","mla":"Miranda, Osvaldo. Unraveling the Role of Pten in Cortical Stem Cell Lineage Progression Using MADM. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20212.","chicago":"Miranda, Osvaldo. “Unraveling the Role of Pten in Cortical Stem Cell Lineage Progression Using MADM.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20212."},"has_accepted_license":"1","acknowledgement":"I would also like to\r\nthank the Austrian Academy of Sciences for awarding me a 2-year DOC fellowship\r\n(DOC26253).","oa_version":"Published Version","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"17425"}]},"title":"Unraveling the role of Pten in cortical stem cell lineage progression using MADM","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}]},{"citation":{"ama":"Iani E, Rinaldi P, Caputi KI, et al. MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. The Astrophysical Journal. 2025;989(2). doi:10.3847/1538-4357/ade5a6","short":"E. Iani, P. Rinaldi, K.I. Caputi, M. Annunziatella, D. Langeroodi, J. Melinder, P.G. Pérez-González, J. Álvarez-Márquez, L.A. Boogaard, S.E.I. Bosman, L. Costantin, T. Moutard, L. Colina, G. Östlin, T.R. Greve, G. Wright, A. Alonso-Herrero, A. Bik, S. Gillman, A. Crespo Gómez, J. Hjorth, S. Kendrew, A. Labiano, J.P. Pye, T.V. Tikkanen, F. Walter, M. Güdel, T. Henning, P.P. Van Der Werf, The Astrophysical Journal 989 (2025).","ieee":"E. Iani et al., “MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6,” The Astrophysical Journal, vol. 989, no. 2. IOP Publishing, 2025.","ista":"Iani E, Rinaldi P, Caputi KI, Annunziatella M, Langeroodi D, Melinder J, Pérez-González PG, Álvarez-Márquez J, Boogaard LA, Bosman SEI, Costantin L, Moutard T, Colina L, Östlin G, Greve TR, Wright G, Alonso-Herrero A, Bik A, Gillman S, Crespo Gómez A, Hjorth J, Kendrew S, Labiano A, Pye JP, Tikkanen TV, Walter F, Güdel M, Henning T, Van Der Werf PP. 2025. MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. The Astrophysical Journal. 989(2), 160.","apa":"Iani, E., Rinaldi, P., Caputi, K. I., Annunziatella, M., Langeroodi, D., Melinder, J., … Van Der Werf, P. P. (2025). MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ade5a6","chicago":"Iani, Edoardo, Pierluigi Rinaldi, Karina I. Caputi, Marianna Annunziatella, Danial Langeroodi, Jens Melinder, Pablo G. Pérez-González, et al. “MIDIS: MIRI Uncovers Virgil, the First Little Red Dot with Clear Detection of Its Host Galaxy at z ≃ 6.6.” The Astrophysical Journal. IOP Publishing, 2025. https://doi.org/10.3847/1538-4357/ade5a6.","mla":"Iani, Edoardo, et al. “MIDIS: MIRI Uncovers Virgil, the First Little Red Dot with Clear Detection of Its Host Galaxy at z ≃ 6.6.” The Astrophysical Journal, vol. 989, no. 2, 160, IOP Publishing, 2025, doi:10.3847/1538-4357/ade5a6."},"arxiv":1,"has_accepted_license":"1","title":"MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6","acknowledgement":"The authors thank R. Cooper, G. Yang, V. Kokorev, D. Wen, C. Williams, and H. Übler for useful discussions and comments.\r\nE.I. and K.I.C. acknowledge funding from the Netherlands Research School for Astronomy (NOVA). K.I.C. acknowledges funding from the Dutch Research Council (NWO) through the award of the Vici grant VI.C.212.036. A.A.-H. acknowledges support from grant PID2021-124665NB-I00 funded by MCIN/AEI/10.13039/ 501100011033 and by “ERDF A way of making Europe.” P.G.P.-G. acknowledges support from grant PID2022-139567NB-I00 funded by the Spanish Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033, FEDER Una manera de hacer Europa. J.A.-M., A.C.-G., and L.C. acknowledge support by grant PIB2021-127718NB-100 from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe.” L.C. thanks the support from the Cosmic Dawn Center received during visits to DAWN as an international associate. L.C. acknowledges support by grants PIB2021-127718NB-100 and PID2022-139567NB-I00 from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe.” T.R.G. acknowledges support from the Carlsberg Foundation (grant No. CF20-0534). S.G. acknowledges financial support from the Cosmic Dawn Center (DAWN), funded by the Danish National Research Foundation (DNRF) under grant No. 140. This work was supported by research grants (VIL16599, VIL54489) from VILLUM FONDEN. J.P.P. and T.V.T. acknowledge financial support from the UK Science and Technology Facilities Council and the UK Space Agency.\r\n\r\nThis work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the MAST at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs GO #1963, GO #1895, and GTO #1283. The authors acknowledge the team led by co-PIs: C. Williams, M. Maseda, and S. Tacchella, and PI P. Oesch, for developing their respective observing programs with a zero-exclusive-access period. Also based on observations made with the NASA/ESA HST obtained from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. The work presented here is the effort of the entire MIRI team, and the enthusiasm within the MIRI partnership is a significant factor in its success. MIRI draws on the scientific and technical expertise of the following organizations: Ames Research Center, USA; Airbus Defence and Space, UK; CEA-Irfu, Saclay, France; Centre Spatial de Liège, Belgium; Consejo Superior de Investigaciones Científicas, Spain; Carl Zeiss Optronics, Germany; Chalmers University of Technology, Sweden; Danish Space Research Institute, Denmark; Dublin Institute for Advanced Studies, Ireland; European Space Agency, Netherlands; ETCA, Belgium; ETH Zurich, Switzerland; Goddard Space Flight Center, USA; Institute d’Astrophysique Spatiale, France; Instituto Nacional de Técnica Aeroespacial, Spain; Institute for Astronomy, Edinburgh, UK; Jet Propulsion Laboratory, USA; Laboratoire d’Astrophysique de Marseille (LAM), France; Leiden University, Netherlands; Lockheed Advanced Technology Center (USA); NOVA Opt-IR group at Dwingeloo, Netherlands; Northrop Grumman, USA; Max-Planck Institut für Astronomie (MPIA), Heidelberg, Germany; Laboratoire d’Etudes Spatiales et d’Instrumentation en Astrophysique (LESIA), France; Paul Scherrer Institut, Switzerland; Raytheon Vision Systems, USA; RUAG Aerospace, Switzerland; Rutherford Appleton Laboratory (RAL Space), UK; Space Telescope Science Institute, USA; Toegepast-Natuurwetenschappelijk Onderzoek (TNO-TPD), Netherlands; UK Astronomy Technology Centre, UK; University College London, UK; University of Amsterdam, Netherlands; University of Arizona, USA; University of Cardiff, UK; University of Cologne, Germany; University of Ghent; University of Groningen, Netherlands; University of Leicester, UK; University of Leuven, Belgium; University of Stockholm, Sweden; Utah State University, USA.\r\nFor the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to the Author Accepted Manuscript version arising from this submission.","scopus_import":"1","oa_version":"Published Version","OA_type":"gold","isi":1,"article_type":"original","article_processing_charge":"Yes","issue":"2","_id":"20217","DOAJ_listed":"1","PlanS_conform":"1","language":[{"iso":"eng"}],"oa":1,"author":[{"last_name":"Iani","orcid":"0000-0001-8386-3546","full_name":"Iani, Edoardo","id":"4053390a-6b68-11ef-9828-a3b8adef8d0a","first_name":"Edoardo"},{"full_name":"Rinaldi, Pierluigi","last_name":"Rinaldi","first_name":"Pierluigi"},{"first_name":"Karina I.","full_name":"Caputi, Karina I.","last_name":"Caputi"},{"last_name":"Annunziatella","full_name":"Annunziatella, Marianna","first_name":"Marianna"},{"first_name":"Danial","full_name":"Langeroodi, Danial","last_name":"Langeroodi"},{"first_name":"Jens","full_name":"Melinder, Jens","last_name":"Melinder"},{"first_name":"Pablo G.","full_name":"Pérez-González, Pablo G.","last_name":"Pérez-González"},{"full_name":"Álvarez-Márquez, Javier","last_name":"Álvarez-Márquez","first_name":"Javier"},{"first_name":"Leindert A.","full_name":"Boogaard, Leindert A.","last_name":"Boogaard"},{"full_name":"Bosman, Sarah E.I.","last_name":"Bosman","first_name":"Sarah E.I."},{"last_name":"Costantin","full_name":"Costantin, Luca","first_name":"Luca"},{"full_name":"Moutard, Thibaud","last_name":"Moutard","first_name":"Thibaud"},{"last_name":"Colina","full_name":"Colina, Luis","first_name":"Luis"},{"full_name":"Östlin, Göran","last_name":"Östlin","first_name":"Göran"},{"last_name":"Greve","full_name":"Greve, Thomas R.","first_name":"Thomas R."},{"last_name":"Wright","full_name":"Wright, Gillian","first_name":"Gillian"},{"first_name":"Almudena","full_name":"Alonso-Herrero, Almudena","last_name":"Alonso-Herrero"},{"last_name":"Bik","full_name":"Bik, Arjan","first_name":"Arjan"},{"last_name":"Gillman","full_name":"Gillman, Steven","first_name":"Steven"},{"full_name":"Crespo Gómez, Alejandro","last_name":"Crespo Gómez","first_name":"Alejandro"},{"full_name":"Hjorth, Jens","last_name":"Hjorth","first_name":"Jens"},{"full_name":"Kendrew, Sarah","last_name":"Kendrew","first_name":"Sarah"},{"first_name":"Alvaro","full_name":"Labiano, Alvaro","last_name":"Labiano"},{"first_name":"John P.","last_name":"Pye","full_name":"Pye, John P."},{"first_name":"Tuomo V.","full_name":"Tikkanen, Tuomo V.","last_name":"Tikkanen"},{"full_name":"Walter, Fabian","last_name":"Walter","first_name":"Fabian"},{"first_name":"Manuel","last_name":"Güdel","full_name":"Güdel, Manuel"},{"full_name":"Henning, Thomas","last_name":"Henning","first_name":"Thomas"},{"first_name":"Paul P.","last_name":"Van Der Werf","full_name":"Van Der Werf, Paul P."}],"type":"journal_article","day":"20","status":"public","OA_place":"publisher","month":"08","quality_controlled":"1","article_number":"160","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"publisher":"IOP Publishing","file_date_updated":"2025-09-02T06:40:23Z","file":[{"date_updated":"2025-09-02T06:40:23Z","file_size":5474992,"file_name":"2025_AstrophysicalJour_Iani.pdf","access_level":"open_access","creator":"dernst","success":1,"content_type":"application/pdf","date_created":"2025-09-02T06:40:23Z","relation":"main_file","file_id":"20268","checksum":"92196e8352dddb1f305c253da1996ab6"}],"intvolume":" 989","publication":"The Astrophysical Journal","publication_status":"published","external_id":{"arxiv":["2406.18207"],"isi":["001548132000001"]},"department":[{"_id":"JoMa"}],"abstract":[{"text":"We present Virgil, a Mid-Infrared Instrument (MIRI) extremely red object detected with the F1000W filter as part of the MIRI Deep Imaging Survey observations of the Hubble Ultra Deep Field. Virgil is an Lyα emitter (LAE) at zspec = 6.6312 ± 0.0019 (from the Very Large Telescope/MUSE) with a rest-frame UV-to-optical spectral energy distribution (SED) typical of LAEs at similar redshifts. However, MIRI observations reveal an unexpected extremely red color at rest-frame near-infrared (NIR) wavelengths, F444W − F1000W = 2.33 ± 0.06. Such a steep\r\nrise in the NIR, completely missed without MIRI imaging, is poorly reproduced by models including only stellar populations and hints toward the presence of an active galactic nucleus, although alternative explanations such as extreme dust obscuration and strong nebular continuum and emission lines contribution due to young stellar ages cannot be completely ruled out. According to the shape of its overall SED, Virgil belongs to the recently discovered\r\npopulation of little red dots but displays an extended rest-frame UV-optical wavelength morphology following a 2DSérsic profile with an average index of n = 0.93+0.85_0.31 and re = 0.49+0.05_0.11 pkpc. Only at MIRI wavelengths, Virgil is unresolved due to the coarser point-spread function. This discovery demonstrates the crucial importance of deep MIRI surveys to reveal the true nature and properties of high-z galaxies that otherwise would be misinterpreted and raises the question of how common Virgil-like objects could be in the early Universe.","lang":"eng"}],"doi":"10.3847/1538-4357/ade5a6","ddc":["520"],"date_published":"2025-08-20T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":989,"date_updated":"2026-02-16T12:43:12Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2025","date_created":"2025-08-24T22:01:29Z"},{"file_date_updated":"2025-09-02T07:22:48Z","intvolume":" 37","publication":"Journal of Physics Condensed Matter","file":[{"file_size":8997829,"date_updated":"2025-09-02T07:22:48Z","file_name":"2025_CondensedMatter_Volpe.pdf","access_level":"open_access","creator":"dernst","content_type":"application/pdf","success":1,"date_created":"2025-09-02T07:22:48Z","relation":"main_file","file_id":"20271","checksum":"7309274f78bed785b158bd290337f456"}],"external_id":{"isi":["001550090200001"],"arxiv":["2407.10623"]},"department":[{"_id":"JePa"}],"publication_status":"published","doi":"10.1088/1361-648X/adebd3","abstract":[{"text":"Humanity has long sought inspiration from nature to innovate materials and devices. As science advances, nature-inspired materials are becoming part of our lives. Animate materials, characterized by their activity, adaptability, and autonomy, emulate properties of living systems. While only biological materials fully embody these principles, artificial versions are advancing rapidly, promising transformative impacts in the circular economy, health and climate resilience within a generation. This roadmap presents authoritative perspectives on animate materials across different disciplines and scales, highlighting their interdisciplinary nature and potential applications in diverse fields including nanotechnology, robotics and the built environment. It underscores the need for concerted efforts to address shared challenges such as complexity management, scalability, evolvability, interdisciplinary collaboration, and ethical and environmental considerations. The framework defined by classifying materials based on their level of animacy can guide this emerging field to encourage cooperation and responsible development. By unravelling the mysteries of living matter and leveraging its principles, we can design materials and systems that will transform our world in a more sustainable manner.","lang":"eng"}],"ddc":["530"],"date_published":"2025-08-18T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"volume":37,"date_updated":"2025-09-30T14:25:12Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2025-08-24T22:01:30Z","year":"2025","has_accepted_license":"1","citation":{"ieee":"G. Volpe et al., “Roadmap for animate matter,” Journal of Physics Condensed Matter, vol. 37, no. 33. IOP Publishing, 2025.","short":"G. Volpe, N.A.M. Araújo, M. Guix, M. Miodownik, N. Martin, L. Alvarez, J. Simmchen, R.D. Leonardo, N. Pellicciotta, Q. Martinet, J.A. Palacci, W.K. Ng, D. Saxena, R. Sapienza, S. Nadine, J.F. Mano, R. Mahdavi, C. Beck Adiels, J. Forth, C. Santangelo, S. Palagi, J.M. Seok, V.A. Webster-Wood, S. Wang, L. Yao, A. Aghakhani, T. Barois, H. Kellay, C. Coulais, M. Van Hecke, C.J. Pierce, T. Wang, B. Chong, D.I. Goldman, A. Reina, V. Trianni, G. Volpe, R. Beckett, S.P. Nair, R. Armstrong, Journal of Physics Condensed Matter 37 (2025).","ama":"Volpe G, Araújo NAM, Guix M, et al. Roadmap for animate matter. Journal of Physics Condensed Matter. 2025;37(33). doi:10.1088/1361-648X/adebd3","ista":"Volpe G, Araújo NAM, Guix M, Miodownik M, Martin N, Alvarez L, Simmchen J, Leonardo RD, Pellicciotta N, Martinet Q, Palacci JA, Ng WK, Saxena D, Sapienza R, Nadine S, Mano JF, Mahdavi R, Beck Adiels C, Forth J, Santangelo C, Palagi S, Seok JM, Webster-Wood VA, Wang S, Yao L, Aghakhani A, Barois T, Kellay H, Coulais C, Van Hecke M, Pierce CJ, Wang T, Chong B, Goldman DI, Reina A, Trianni V, Volpe G, Beckett R, Nair SP, Armstrong R. 2025. Roadmap for animate matter. Journal of Physics Condensed Matter. 37(33), 333501.","apa":"Volpe, G., Araújo, N. A. M., Guix, M., Miodownik, M., Martin, N., Alvarez, L., … Armstrong, R. (2025). Roadmap for animate matter. Journal of Physics Condensed Matter. IOP Publishing. https://doi.org/10.1088/1361-648X/adebd3","chicago":"Volpe, Giorgio, Nuno A.M. Araújo, Maria Guix, Mark Miodownik, Nicolas Martin, Laura Alvarez, Juliane Simmchen, et al. “Roadmap for Animate Matter.” Journal of Physics Condensed Matter. IOP Publishing, 2025. https://doi.org/10.1088/1361-648X/adebd3.","mla":"Volpe, Giorgio, et al. “Roadmap for Animate Matter.” Journal of Physics Condensed Matter, vol. 37, no. 33, 333501, IOP Publishing, 2025, doi:10.1088/1361-648X/adebd3."},"arxiv":1,"title":"Roadmap for animate matter","isi":1,"OA_type":"hybrid","acknowledgement":"Living Architecture is Funded by the EU Horizon 2020 Future Emerging Technologies Open programme (2016–2019) Grant Agreement 686585 a consortium of 6 collaborating institutions—Newcastle University, University of Trento, University of the West of England, Spanish National Research Council, Explora Biotech and Liquifer Systems Group.\r\n\r\nThe Active Living Infrastructure: Controlled Environment (ALICE) project is funded by an EU Innovation Award for the development of a bio-digital ‘brick’ prototype, a collaboration between Newcastle University, Translating Nature, and the University of the West of England (2019–2021) under EU Grant Agreement No. 851246.\r\n\r\nMicrobial Hydroponics: Circular Sustainable Electrobiosynthesis (Mi-Hy) is Funded by the European Union under Grant Agreement Number 101114746, which is a collaboration between Beneficiaries, KU Leuven (Belgium), the University of Southampton (UK), SONY Computer Science Laboratory (France), BioFaction KG (Austria), Spanish National Research Council (Spain), and Associated Partners, the University of the West of England (UK) and University of Southampton (UK). Mi-Hy is also supported through the interdisciplinary KU Leuven Institute for Cultural Heritage (HERKUL).","scopus_import":"1","oa_version":"Published Version","issue":"33","_id":"20218","PlanS_conform":"1","article_processing_charge":"Yes (in subscription journal)","article_type":"original","author":[{"first_name":"Giorgio","last_name":"Volpe","full_name":"Volpe, Giorgio"},{"first_name":"Nuno A.M.","last_name":"Araújo","full_name":"Araújo, Nuno A.M."},{"first_name":"Maria","last_name":"Guix","full_name":"Guix, Maria"},{"full_name":"Miodownik, Mark","last_name":"Miodownik","first_name":"Mark"},{"first_name":"Nicolas","full_name":"Martin, Nicolas","last_name":"Martin"},{"first_name":"Laura","full_name":"Alvarez, Laura","last_name":"Alvarez"},{"last_name":"Simmchen","full_name":"Simmchen, Juliane","first_name":"Juliane"},{"last_name":"Leonardo","full_name":"Leonardo, Roberto Di","first_name":"Roberto Di"},{"first_name":"Nicola","last_name":"Pellicciotta","full_name":"Pellicciotta, Nicola"},{"id":"b37485a8-d343-11eb-a0e9-df8c484ef8ab","last_name":"Martinet","orcid":"0000-0002-2916-6632","full_name":"Martinet, Quentin","first_name":"Quentin"},{"first_name":"Jérémie A","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","last_name":"Palacci","orcid":"0000-0002-7253-9465","full_name":"Palacci, Jérémie A"},{"first_name":"Wai Kit","last_name":"Ng","full_name":"Ng, Wai Kit"},{"full_name":"Saxena, Dhruv","last_name":"Saxena","first_name":"Dhruv"},{"full_name":"Sapienza, Riccardo","last_name":"Sapienza","first_name":"Riccardo"},{"first_name":"Sara","last_name":"Nadine","full_name":"Nadine, Sara"},{"last_name":"Mano","full_name":"Mano, João F.","first_name":"João F."},{"first_name":"Reza","full_name":"Mahdavi, Reza","last_name":"Mahdavi"},{"full_name":"Beck Adiels, Caroline","last_name":"Beck Adiels","first_name":"Caroline"},{"full_name":"Forth, Joe","last_name":"Forth","first_name":"Joe"},{"full_name":"Santangelo, Christian","last_name":"Santangelo","first_name":"Christian"},{"first_name":"Stefano","last_name":"Palagi","full_name":"Palagi, Stefano"},{"last_name":"Seok","full_name":"Seok, Ji Min","first_name":"Ji Min"},{"full_name":"Webster-Wood, Victoria A.","last_name":"Webster-Wood","first_name":"Victoria A."},{"first_name":"Shuhong","last_name":"Wang","full_name":"Wang, Shuhong"},{"full_name":"Yao, Lining","last_name":"Yao","first_name":"Lining"},{"first_name":"Amirreza","full_name":"Aghakhani, Amirreza","last_name":"Aghakhani"},{"first_name":"Thomas","last_name":"Barois","full_name":"Barois, Thomas"},{"full_name":"Kellay, Hamid","last_name":"Kellay","first_name":"Hamid"},{"first_name":"Corentin","full_name":"Coulais, Corentin","last_name":"Coulais"},{"full_name":"Van Hecke, Martin","last_name":"Van Hecke","first_name":"Martin"},{"full_name":"Pierce, Christopher J.","last_name":"Pierce","first_name":"Christopher J."},{"first_name":"Tianyu","full_name":"Wang, Tianyu","last_name":"Wang"},{"first_name":"Baxi","full_name":"Chong, Baxi","last_name":"Chong"},{"full_name":"Goldman, Daniel I.","last_name":"Goldman","first_name":"Daniel I."},{"last_name":"Reina","full_name":"Reina, Andreagiovanni","first_name":"Andreagiovanni"},{"first_name":"Vito","last_name":"Trianni","full_name":"Trianni, Vito"},{"full_name":"Volpe, Giovanni","last_name":"Volpe","first_name":"Giovanni"},{"first_name":"Richard","last_name":"Beckett","full_name":"Beckett, Richard"},{"first_name":"Sean P.","last_name":"Nair","full_name":"Nair, Sean P."},{"first_name":"Rachel","last_name":"Armstrong","full_name":"Armstrong, Rachel"}],"language":[{"iso":"eng"}],"oa":1,"status":"public","OA_place":"publisher","type":"journal_article","day":"18","publisher":"IOP Publishing","publication_identifier":{"eissn":["1361-648X"],"issn":["0953-8984"]},"article_number":"333501","quality_controlled":"1","month":"08"},{"date_published":"2025-08-13T00:00:00Z","date_updated":"2025-09-30T14:24:40Z","volume":22,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2025-08-24T22:01:30Z","year":"2025","publication":"Journal of the Royal Society Interface","intvolume":" 22","department":[{"_id":"SyCr"}],"external_id":{"isi":["001548084900001"],"pmid":["40799050"]},"publication_status":"published","doi":"10.1098/rsif.2025.0202","abstract":[{"text":"Reproduction is a fundamental biological process, with organisms reproducing sexually, asexually, and, in some cases, utilizing both modes of reproduction within the same population. Does the ability to reproduce through a combination of asexual and sexual modes offer an evolutionary advantage over relying on either mode alone? Here, we introduce an empirically driven theoretical model to examine the dynamics and interplay between sexual and asexual reproduction in stick insect populations. We analyse it using a novel phase transition approach and corroborate it using published experimental data. We find that the presence of males can either increase or decrease the overall population size. However, maintaining an optimal ratio of parthenogenetic to sexual reproduction is crucial for male resilience, effectively delaying male extinction. Conversely, extreme levels of parthenogenetic reproduction—whether too high or too low—can lead to male extinction, emphasizing the need for a balanced number of virgin females to ensure the persistence of males. Our model also explains male absence in Carausius morosus and persistence in Extatosoma tiaratum. Our findings provide valuable insights into the interplay of reproductive strategies and contribute to broader discussions on the transitions between sexual and asexual reproduction.","lang":"eng"}],"issue":"229","_id":"20219","corr_author":"1","article_processing_charge":"No","article_type":"original","author":[{"full_name":"Ayalon, Oran","last_name":"Ayalon","first_name":"Oran"},{"last_name":"Rajendran","full_name":"Rajendran, Harikrishnan","id":"876b6b34-8ff4-11ec-97c9-8d95a7aae416","first_name":"Harikrishnan"}],"language":[{"iso":"eng"}],"status":"public","day":"13","type":"journal_article","publisher":"The Royal Society","publication_identifier":{"eissn":["1742-5662"],"issn":["1742-5689"]},"article_number":"20250202","quality_controlled":"1","month":"08","pmid":1,"citation":{"ieee":"O. Ayalon and H. Rajendran, “Interplay of asexual and sexual reproduction in bifunctional insects,” Journal of the Royal Society Interface, vol. 22, no. 229. The Royal Society, 2025.","ama":"Ayalon O, Rajendran H. Interplay of asexual and sexual reproduction in bifunctional insects. Journal of the Royal Society Interface. 2025;22(229). doi:10.1098/rsif.2025.0202","short":"O. Ayalon, H. Rajendran, Journal of the Royal Society Interface 22 (2025).","ista":"Ayalon O, Rajendran H. 2025. Interplay of asexual and sexual reproduction in bifunctional insects. Journal of the Royal Society Interface. 22(229), 20250202.","apa":"Ayalon, O., & Rajendran, H. (2025). Interplay of asexual and sexual reproduction in bifunctional insects. Journal of the Royal Society Interface. The Royal Society. https://doi.org/10.1098/rsif.2025.0202","mla":"Ayalon, Oran, and Harikrishnan Rajendran. “Interplay of Asexual and Sexual Reproduction in Bifunctional Insects.” Journal of the Royal Society Interface, vol. 22, no. 229, 20250202, The Royal Society, 2025, doi:10.1098/rsif.2025.0202.","chicago":"Ayalon, Oran, and Harikrishnan Rajendran. “Interplay of Asexual and Sexual Reproduction in Bifunctional Insects.” Journal of the Royal Society Interface. The Royal Society, 2025. https://doi.org/10.1098/rsif.2025.0202."},"title":"Interplay of asexual and sexual reproduction in bifunctional insects","isi":1,"OA_type":"closed access","scopus_import":"1","acknowledgement":"We acknowledge Prof. Uri Alon for introducing us to the topic of systems biology during the graduate course at the Weizmann Institute of Science, whose insights and teachings have greatly inspired this work.","oa_version":"None"},{"month":"08","quality_controlled":"1","publisher":"AAAS","publication_identifier":{"eissn":["2375-2548"]},"day":"08","type":"journal_article","OA_place":"publisher","status":"public","page":"eadr5694","language":[{"iso":"eng"}],"oa":1,"license":"https://creativecommons.org/licenses/by-nc/4.0/","author":[{"last_name":"De Jaeger-Braet","full_name":"De Jaeger-Braet, Joke G","id":"26bd38d3-c59a-11ee-a1af-d7a988cafcc5","first_name":"Joke G"},{"full_name":"Hartmann, Merle","last_name":"Hartmann","first_name":"Merle"},{"first_name":"Lev","full_name":"Böttger, Lev","last_name":"Böttger"},{"full_name":"Yang, Chao","last_name":"Yang","id":"082e3e6e-8069-11ed-8390-c8cce7b1aaca","first_name":"Chao"},{"first_name":"Takahiro","full_name":"Hamada, Takahiro","last_name":"Hamada"},{"first_name":"Stefan","full_name":"Hoth, Stefan","last_name":"Hoth"},{"first_name":"Xiaoqi","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","last_name":"Feng","orcid":"0000-0002-4008-1234","full_name":"Feng, Xiaoqi"},{"full_name":"Weingartner, Magdalena","last_name":"Weingartner","first_name":"Magdalena"},{"last_name":"Schnittger","full_name":"Schnittger, Arp","first_name":"Arp"}],"article_type":"original","article_processing_charge":"Yes","_id":"20220","issue":"32","DOAJ_listed":"1","scopus_import":"1","oa_version":"Published Version","acknowledgement":"We thank L. Strader (Duke University, Durham) and A. Holehouse (Washington University, Saint Louis) for discussion and input in LLPS. We thank T. Nakagawa (Shimane University, Matsue) for providing the pGWB604 Gateway vector containing bar gene identified by Meiji Seika Kaisha Ltd. We thank M. Heese (Hamburg University) for the critical reading and comments on this manuscript. We further thank J. Mehrmann (Hamburg University) for technical assistance. We thank the ISTA imaging facility for assistance for microscopy.\r\nThis project has received funding from JST-PRESTO (JPMJPR18H7), JST-CREST (JPMJCR18H4), European Union’s Horizon 2020 under MSCA grant 101034413, and a federal grant from the state of Hamburg (LFF-BiCon).","isi":1,"OA_type":"gold","title":"The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat","acknowledged_ssus":[{"_id":"Bio"}],"citation":{"short":"J.G. De Jaeger-Braet, M. Hartmann, L. Böttger, C. Yang, T. Hamada, S. Hoth, X. Feng, M. Weingartner, A. Schnittger, Science Advances 11 (2025) eadr5694.","ieee":"J. G. De Jaeger-Braet et al., “The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat,” Science Advances, vol. 11, no. 32. AAAS, p. eadr5694, 2025.","ama":"De Jaeger-Braet JG, Hartmann M, Böttger L, et al. The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. Science Advances. 2025;11(32):eadr5694. doi:10.1126/sciadv.adr5694","ista":"De Jaeger-Braet JG, Hartmann M, Böttger L, Yang C, Hamada T, Hoth S, Feng X, Weingartner M, Schnittger A. 2025. The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. Science Advances. 11(32), eadr5694.","apa":"De Jaeger-Braet, J. G., Hartmann, M., Böttger, L., Yang, C., Hamada, T., Hoth, S., … Schnittger, A. (2025). The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. Science Advances. AAAS. https://doi.org/10.1126/sciadv.adr5694","chicago":"De Jaeger-Braet, Joke G, Merle Hartmann, Lev Böttger, Chao Yang, Takahiro Hamada, Stefan Hoth, Xiaoqi Feng, Magdalena Weingartner, and Arp Schnittger. “The Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” Science Advances. AAAS, 2025. https://doi.org/10.1126/sciadv.adr5694.","mla":"De Jaeger-Braet, Joke G., et al. “The Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” Science Advances, vol. 11, no. 32, AAAS, 2025, p. eadr5694, doi:10.1126/sciadv.adr5694."},"has_accepted_license":"1","year":"2025","date_created":"2025-08-24T22:01:30Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2025-09-30T14:24:10Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"volume":11,"date_published":"2025-08-08T00:00:00Z","project":[{"name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","call_identifier":"H2020"}],"ddc":["580"],"abstract":[{"lang":"eng","text":"Stress granules (SG) are biomolecular condensates that represent an adaptive response of cells to various stresses, including heat. However, the cell type–specific function and relevance of SG formation, especially during reproductive development, are largely not understood. Here, we show that the meiotic A-type cyclin TARDY ASYNCHRONOUS MEIOSIS (TAM) is recruited to SGs in male meiocytes of Arabidopsis after exposure to heat. We find that the amino terminus of TAM is necessary and sufficient for the localization of proteins to meiotic SGs. Swapping the amino terminus of TAM with the one of its sister protein CYCA1;1 resulted in a separation-of-function allele of TAM, which prevents the partitioning of TAM to SGs while restoring a wild-type phenotype in a tam mutant background under nonheat stress conditions. Notably, plants expressing this TAM version prematurely terminate meiosis under heat resulting in unreduced gametes. Thus, the formation of TAM-containing SGs is necessary for genome stability under heat stress."}],"ec_funded":1,"doi":"10.1126/sciadv.adr5694","publication_status":"published","department":[{"_id":"XiFe"}],"external_id":{"isi":["001549102600016"]},"intvolume":" 11","file":[{"creator":"dernst","access_level":"open_access","file_name":"2025_ScienceAdvance_DeJaegerBraet.pdf","file_size":10876817,"date_updated":"2025-09-02T07:05:37Z","file_id":"20270","checksum":"0f1ae246acc9b075f01bf4afe382c8ba","relation":"main_file","date_created":"2025-09-02T07:05:37Z","success":1,"content_type":"application/pdf"}],"publication":"Science Advances","file_date_updated":"2025-09-02T07:05:37Z"},{"pmid":1,"has_accepted_license":"1","citation":{"chicago":"Shi, Wanzhuo, Mengjiao Wang, Latha Venkataraman, and John D. Tovar. “Single-Molecule Conductance through Hybrid Radially and Linearly π-Conjugated Macromolecules Reveals an Unusual Intramolecular π-Interaction.” Nano Letters. American Chemical Society, 2025. https://doi.org/10.1021/acs.nanolett.5c03693.","mla":"Shi, Wanzhuo, et al. “Single-Molecule Conductance through Hybrid Radially and Linearly π-Conjugated Macromolecules Reveals an Unusual Intramolecular π-Interaction.” Nano Letters, vol. 25, no. 31, American Chemical Society, 2025, pp. 12101–06, doi:10.1021/acs.nanolett.5c03693.","apa":"Shi, W., Wang, M., Venkataraman, L., & Tovar, J. D. (2025). Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction. Nano Letters. American Chemical Society. https://doi.org/10.1021/acs.nanolett.5c03693","ista":"Shi W, Wang M, Venkataraman L, Tovar JD. 2025. Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction. Nano Letters. 25(31), 12101–12106.","short":"W. Shi, M. Wang, L. Venkataraman, J.D. Tovar, Nano Letters 25 (2025) 12101–12106.","ama":"Shi W, Wang M, Venkataraman L, Tovar JD. Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction. Nano Letters. 2025;25(31):12101-12106. doi:10.1021/acs.nanolett.5c03693","ieee":"W. Shi, M. Wang, L. Venkataraman, and J. D. Tovar, “Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction,” Nano Letters, vol. 25, no. 31. American Chemical Society, pp. 12101–12106, 2025."},"title":"Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction","OA_type":"hybrid","isi":1,"oa_version":"Published Version","scopus_import":"1","acknowledgement":"We thank Prof. Volker Blum for useful discussions. We thank the Department of Energy Office of Basic Energy Science (DE-SC0019017) and the National Science Foundation (NSF-DMR 2241180) for supporting this research. This work was supported in part by the Institute of Science and Technology Austria.","issue":"31","_id":"20221","corr_author":"1","PlanS_conform":"1","article_processing_charge":"Yes (via OA deal)","article_type":"original","author":[{"id":"a3010425-87c8-11f0-8106-bec32bea74da","last_name":"Shi","full_name":"Shi, Wanzhuo","first_name":"Wanzhuo"},{"first_name":"Mengjiao","last_name":"Wang","full_name":"Wang, Mengjiao"},{"first_name":"Latha","orcid":"0000-0002-6957-6089","full_name":"Venkataraman, Latha","last_name":"Venkataraman","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf"},{"last_name":"Tovar","full_name":"Tovar, John D.","first_name":"John D."}],"language":[{"iso":"eng"}],"oa":1,"status":"public","page":"12101-12106","OA_place":"publisher","type":"journal_article","day":"24","publisher":"American Chemical Society","publication_identifier":{"eissn":["1530-6992"]},"month":"07","quality_controlled":"1","file_date_updated":"2025-09-02T06:50:11Z","publication":"Nano Letters","intvolume":" 25","file":[{"date_created":"2025-09-02T06:50:11Z","content_type":"application/pdf","success":1,"checksum":"bfc167d8904c0c47c3de2a8d0ec699d5","file_id":"20269","relation":"main_file","access_level":"open_access","date_updated":"2025-09-02T06:50:11Z","file_size":3212706,"file_name":"2025_NanoLetters_Shi.pdf","creator":"dernst"}],"external_id":{"isi":["001537145800001"],"pmid":["40707400"]},"department":[{"_id":"LaVe"}],"publication_status":"published","doi":"10.1021/acs.nanolett.5c03693","abstract":[{"lang":"eng","text":"We describe the design, synthesis, and single-molecule junction conductance of π-electron molecules bearing both radial and linear π-conjugation pathways, whereby cycloparaphenylene (CPP) radial cores are π-extended linearly with aryl alkyne substituents as models for previously reported CPP-arylene ethynylene conjugated polymers. Although radially and linearly conjugated molecules have been studied previously in isolation as junction-bridging molecular electronic units, this is the first study to examine molecules where both topologies are operative. Our results reveal that the presence of radial CPP components within the junction-spanning pathway leads to a reduction in the conductance of the backbone compared to model linear phenyl substituents. Through tight-binding and DFT-based calculations, we attribute this conductance change to intramolecular van der Waals (vdW) interactions between the CPP ring and the junction-spanning arylene-ethynylene molecular backbone. These interactions induce changes in the dihedral angles of the backbone, leading to a reduced overlap of π orbitals within the molecular junction."}],"ddc":["540"],"date_published":"2025-07-24T00:00:00Z","volume":25,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_updated":"2025-09-30T14:23:39Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2025-08-24T22:01:30Z","year":"2025"},{"oa":1,"language":[{"iso":"eng"}],"author":[{"first_name":"Andrea","full_name":"Mrnjavac, Andrea","last_name":"Mrnjavac","id":"353FAC84-AE61-11E9-8BFC-00D3E5697425"},{"last_name":"Vicoso","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz"},{"first_name":"Tim","full_name":"Connallon, Tim","last_name":"Connallon"}],"article_type":"original","article_processing_charge":"Yes","_id":"20223","issue":"8","DOAJ_listed":"1","PlanS_conform":"1","month":"08","quality_controlled":"1","publisher":"Oxford University Press","publication_identifier":{"issn":["0737-4038"],"eissn":["1537-1719"]},"article_number":"msaf177","type":"journal_article","day":"01","status":"public","OA_place":"publisher","citation":{"mla":"Mrnjavac, Andrea, et al. “An Extension of Muller’s Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.” Molecular Biology and Evolution, vol. 42, no. 8, msaf177, Oxford University Press, 2025, doi:10.1093/molbev/msaf177.","chicago":"Mrnjavac, Andrea, Beatriz Vicoso, and Tim Connallon. “An Extension of Muller’s Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.” Molecular Biology and Evolution. Oxford University Press, 2025. https://doi.org/10.1093/molbev/msaf177.","apa":"Mrnjavac, A., Vicoso, B., & Connallon, T. (2025). An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content. Molecular Biology and Evolution. Oxford University Press. https://doi.org/10.1093/molbev/msaf177","ista":"Mrnjavac A, Vicoso B, Connallon T. 2025. An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content. Molecular Biology and Evolution. 42(8), msaf177.","short":"A. Mrnjavac, B. Vicoso, T. Connallon, Molecular Biology and Evolution 42 (2025).","ama":"Mrnjavac A, Vicoso B, Connallon T. An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content. Molecular Biology and Evolution. 2025;42(8). doi:10.1093/molbev/msaf177","ieee":"A. Mrnjavac, B. Vicoso, and T. Connallon, “An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content,” Molecular Biology and Evolution, vol. 42, no. 8. Oxford University Press, 2025."},"has_accepted_license":"1","pmid":1,"acknowledgement":"We thank Filip Ruzicka, Colin Olito, Akane Uesugi, Melissa Toups, Daniel Jeffries, the Associate Editor, and anonymous reviewers, for comments and suggestions on earlier versions of the paper. We are particularly grateful to Deborah Charlesworth and Brian Charlesworth for extensive comments on two different drafts of the manuscript. We also thank Aneil Agrawal and Thomas Lenormand for email correspondence about the data on dominance and ways to interpret it. Technical support was provided by ISTA Scientific Computing Unit.","oa_version":"Published Version","scopus_import":"1","OA_type":"gold","isi":1,"title":"An extension of Muller's sheltering hypothesis for the evolution of sex chromosome gene content","related_material":{"link":[{"url":"https://git.ista.ac.at/bvicoso/xydegenerate","relation":"software"}]},"acknowledged_ssus":[{"_id":"ScienComp"}],"volume":42,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_updated":"2025-09-30T14:25:57Z","ddc":["570"],"date_published":"2025-08-01T00:00:00Z","year":"2025","date_created":"2025-08-24T22:01:31Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","intvolume":" 42","publication":"Molecular Biology and Evolution","file":[{"file_id":"20274","checksum":"f40abffa56cb1e9ff65800f2a7d7b39a","relation":"main_file","date_created":"2025-09-02T07:47:32Z","content_type":"application/pdf","success":1,"creator":"dernst","access_level":"open_access","date_updated":"2025-09-02T07:47:32Z","file_size":1239841,"file_name":"2025_MolecularBioEvolution_Mrnjavac.pdf"}],"file_date_updated":"2025-09-02T07:47:32Z","abstract":[{"lang":"eng","text":"The first influential hypothesis for sex chromosome evolution was proposed in 1914 by H. J. Muller, who argued that once recombination was suppressed between the X and Y chromosomes, Y-linked genes become “sheltered” from selection, leading to accumulation of recessive loss-of-function (LOF) mutations and decay of Y-linked genes. The hypothesis fell out of favor in the 1970s because early mathematical models failed to support it and data on the dominance of lethal mutations were viewed as incompatible with the hypothesis. We reevaluate the main arguments against Muller's hypothesis and find that they do not conclusively exclude a role for sheltering in sex chromosome evolution. By relaxing restrictive assumptions of earlier models, we show that sheltering promotes fixation of LOF mutations with sexually dimorphic fitness effects, resulting in decay of X-linked genes that are exclusively expressed by males and Y-linked genes that are primarily, though not necessarily exclusively, expressed by females. We further show that drift and other processes contributing to Y degeneration (i.e. selective interference and regulatory evolution) expand conditions of Y-linked gene loss by sheltering. The actual contribution of sheltering to sex chromosome evolution hinges upon the distribution of dominance and sex-specific fitness effects of LOF mutations, which we discuss."}],"doi":"10.1093/molbev/msaf177","publication_status":"published","external_id":{"pmid":["40713898"],"isi":["001547617100001"]},"department":[{"_id":"BeVi"}]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2025-08-24T22:01:31Z","year":"2025","ddc":["000"],"date_published":"2025-07-13T00:00:00Z","conference":{"start_date":"2025-07-14","location":"Malaga, Spain","end_date":"2025-07-18","name":"GECCO: Genetic and evolutionary computation conference"},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"date_updated":"2025-12-01T12:35:24Z","external_id":{"isi":["001556459900031"]},"department":[{"_id":"DaAl"}],"publication_status":"published","doi":"10.1145/3712256.3726425","abstract":[{"text":"Traffic in datacenters may follow some pattern: some pairs of servers communicate more frequently than others. Demand-oblivious networks may perform poorly for such workloads, and demand-aware networks optimized for traffic should be used instead. Unfortunately, not all shapes of networks are feasible in real hardware. Practical limitations are usually provided in the form of a topology. For example, a network may be required to be a binary tree, a bounded-degree graph or a Fat tree.\r\nIn this work, we consider a topology of a binary tree, one of the most fundamental network topologies. We show that already finding an optimal demand-aware binary tree network is NP-hard. Then, we explore how various optimization techniques, including simple local searches, as well as deterministic mutation and crossover operators, cope with generating efficient tree networks on real-life and synthetic workloads.","lang":"eng"}],"file_date_updated":"2025-09-02T07:41:13Z","file":[{"file_id":"20273","checksum":"7e513fa508cff7e8a0d33f50b1fe09af","relation":"main_file","date_created":"2025-09-02T07:41:13Z","success":1,"content_type":"application/pdf","creator":"dernst","access_level":"open_access","date_updated":"2025-09-02T07:41:13Z","file_size":608996,"file_name":"2025_GECCO_Martynov.pdf"}],"publication":"Proceedings of the 2025 Genetic and Evolutionary Computation Conference","status":"public","page":"249-257","OA_place":"publisher","type":"conference","day":"13","publication_identifier":{"isbn":["9798400714658"]},"publisher":"Association for Computing Machinery","quality_controlled":"1","month":"07","_id":"20224","article_processing_charge":"Yes (in subscription journal)","author":[{"first_name":"Pavel","full_name":"Martynov, Pavel","last_name":"Martynov"},{"last_name":"Buzdalov","full_name":"Buzdalov, Maxim","first_name":"Maxim"},{"first_name":"Sergei","full_name":"Pankratov, Sergei","last_name":"Pankratov","id":"f773bf05-72ef-11ef-b75a-a383d22f454b"},{"full_name":"Aksenov, Vitaliy","last_name":"Aksenov","first_name":"Vitaliy"},{"first_name":"Stefan","full_name":"Schmid, Stefan","last_name":"Schmid"}],"oa":1,"language":[{"iso":"eng"}],"title":"In the search of optimal tree networks: Hardness and heuristics","isi":1,"OA_type":"hybrid","scopus_import":"1","oa_version":"Published Version","acknowledgement":"Research was supported by the German Research Foundation (DFG), grant 470029389 (FlexNets).","has_accepted_license":"1","citation":{"ista":"Martynov P, Buzdalov M, Pankratov S, Aksenov V, Schmid S. 2025. In the search of optimal tree networks: Hardness and heuristics. Proceedings of the 2025 Genetic and Evolutionary Computation Conference. GECCO: Genetic and evolutionary computation conference, 249–257.","apa":"Martynov, P., Buzdalov, M., Pankratov, S., Aksenov, V., & Schmid, S. (2025). In the search of optimal tree networks: Hardness and heuristics. In Proceedings of the 2025 Genetic and Evolutionary Computation Conference (pp. 249–257). Malaga, Spain: Association for Computing Machinery. https://doi.org/10.1145/3712256.3726425","ama":"Martynov P, Buzdalov M, Pankratov S, Aksenov V, Schmid S. In the search of optimal tree networks: Hardness and heuristics. In: Proceedings of the 2025 Genetic and Evolutionary Computation Conference. Association for Computing Machinery; 2025:249-257. doi:10.1145/3712256.3726425","short":"P. Martynov, M. Buzdalov, S. Pankratov, V. Aksenov, S. Schmid, in:, Proceedings of the 2025 Genetic and Evolutionary Computation Conference, Association for Computing Machinery, 2025, pp. 249–257.","ieee":"P. Martynov, M. Buzdalov, S. Pankratov, V. Aksenov, and S. Schmid, “In the search of optimal tree networks: Hardness and heuristics,” in Proceedings of the 2025 Genetic and Evolutionary Computation Conference, Malaga, Spain, 2025, pp. 249–257.","chicago":"Martynov, Pavel, Maxim Buzdalov, Sergei Pankratov, Vitaliy Aksenov, and Stefan Schmid. “In the Search of Optimal Tree Networks: Hardness and Heuristics.” In Proceedings of the 2025 Genetic and Evolutionary Computation Conference, 249–57. Association for Computing Machinery, 2025. https://doi.org/10.1145/3712256.3726425.","mla":"Martynov, Pavel, et al. “In the Search of Optimal Tree Networks: Hardness and Heuristics.” Proceedings of the 2025 Genetic and Evolutionary Computation Conference, Association for Computing Machinery, 2025, pp. 249–57, doi:10.1145/3712256.3726425."}},{"abstract":[{"lang":"eng","text":"We present the first supermartingale certificate for quantitative \r\n-regular properties of discrete-time infinite-state stochastic systems. Our certificate is defined on the product of the stochastic system and a limit-deterministic Büchi automaton that specifies the property of interest; hence we call it a limit-deterministic Büchi supermartingale (LDBSM). Previously known supermartingale certificates applied only to quantitative reachability, safety, or reach-avoid properties, and to qualitative (i.e., probability 1) \r\n-regular properties.We also present fully automated algorithms for the template-based synthesis of LDBSMs, for the case when the stochastic system dynamics and the controller can be represented in terms of polynomial inequalities. Our experiments demonstrate the ability of our method to solve verification and control tasks for stochastic systems that were beyond the reach of previous supermartingale-based approaches."}],"ec_funded":1,"doi":"10.1007/978-3-031-98679-6_2","alternative_title":["LNCS"],"publication_status":"published","department":[{"_id":"ToHe"}],"external_id":{"isi":["001562506600002"],"arxiv":["2505.18833"]},"file":[{"creator":"dernst","file_name":"2025_CAV_HenzingerT.pdf","file_size":884831,"date_updated":"2025-09-02T07:34:33Z","access_level":"open_access","relation":"main_file","file_id":"20272","checksum":"beb1e2637de5b2268cc2262119439113","success":1,"content_type":"application/pdf","date_created":"2025-09-02T07:34:33Z"}],"publication":"37th International Conference on Computer Aided Verification","intvolume":" 15932","file_date_updated":"2025-09-02T07:34:33Z","year":"2025","date_created":"2025-08-24T22:01:31Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-12-01T12:34:41Z","volume":15932,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"conference":{"start_date":"2025-07-23","location":"Zagreb, Croatia","end_date":"2025-07-25","name":"CAV: Computer Aided Verification"},"date_published":"2025-07-22T00:00:00Z","project":[{"_id":"62781420-2b32-11ec-9570-8d9b63373d4d","grant_number":"101020093","call_identifier":"H2020","name":"Vigilant Algorithmic Monitoring of Software"}],"ddc":["000"],"scopus_import":"1","acknowledgement":"This work was supported in part by the Singapore Ministry of Education (MOE) Academic Research Fund (AcRF) Tier 1 grant (Project ID:22-SIS-SMU-100) and the ERC project ERC-2020-AdG 101020093.","oa_version":"Published Version","isi":1,"OA_type":"hybrid","title":"Supermartingale certificates for quantitative omega-regular verification and control","arxiv":1,"citation":{"mla":"Henzinger, Thomas A., et al. “Supermartingale Certificates for Quantitative Omega-Regular Verification and Control.” 37th International Conference on Computer Aided Verification, vol. 15932, Springer Nature, 2025, pp. 29–55, doi:10.1007/978-3-031-98679-6_2.","chicago":"Henzinger, Thomas A, Kaushik Mallik, Pouya Sadeghi, and Dorde Zikelic. “Supermartingale Certificates for Quantitative Omega-Regular Verification and Control.” In 37th International Conference on Computer Aided Verification, 15932:29–55. Springer Nature, 2025. https://doi.org/10.1007/978-3-031-98679-6_2.","short":"T.A. Henzinger, K. Mallik, P. Sadeghi, D. Zikelic, in:, 37th International Conference on Computer Aided Verification, Springer Nature, 2025, pp. 29–55.","ama":"Henzinger TA, Mallik K, Sadeghi P, Zikelic D. Supermartingale certificates for quantitative omega-regular verification and control. In: 37th International Conference on Computer Aided Verification. Vol 15932. Springer Nature; 2025:29-55. doi:10.1007/978-3-031-98679-6_2","ieee":"T. A. Henzinger, K. Mallik, P. Sadeghi, and D. Zikelic, “Supermartingale certificates for quantitative omega-regular verification and control,” in 37th International Conference on Computer Aided Verification, Zagreb, Croatia, 2025, vol. 15932, pp. 29–55.","apa":"Henzinger, T. A., Mallik, K., Sadeghi, P., & Zikelic, D. (2025). Supermartingale certificates for quantitative omega-regular verification and control. In 37th International Conference on Computer Aided Verification (Vol. 15932, pp. 29–55). Zagreb, Croatia: Springer Nature. https://doi.org/10.1007/978-3-031-98679-6_2","ista":"Henzinger TA, Mallik K, Sadeghi P, Zikelic D. 2025. Supermartingale certificates for quantitative omega-regular verification and control. 37th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 15932, 29–55."},"has_accepted_license":"1","quality_controlled":"1","month":"07","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783031986789"]},"publisher":"Springer Nature","day":"22","type":"conference","OA_place":"publisher","page":"29-55","status":"public","oa":1,"language":[{"iso":"eng"}],"author":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2985-7724","full_name":"Henzinger, Thomas A","last_name":"Henzinger","first_name":"Thomas A"},{"first_name":"Kaushik","id":"0834ff3c-6d72-11ec-94e0-b5b0a4fb8598","last_name":"Mallik","full_name":"Mallik, Kaushik","orcid":"0000-0001-9864-7475"},{"last_name":"Sadeghi","full_name":"Sadeghi, Pouya","first_name":"Pouya"},{"first_name":"Dorde","last_name":"Zikelic","full_name":"Zikelic, Dorde","orcid":"0000-0002-4681-1699","id":"294AA7A6-F248-11E8-B48F-1D18A9856A87"}],"article_processing_charge":"Yes (in subscription journal)","_id":"20225"},{"date_updated":"2026-06-10T08:45:12Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"oa":1,"author":[{"orcid":"0000-0002-9350-7606","full_name":"Schanda, Paul","last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","first_name":"Paul"}],"date_published":"2025-09-01T00:00:00Z","article_processing_charge":"No","keyword":["sustainability","conference travel"],"_id":"20242","corr_author":"1","month":"09","year":"2025","date_created":"2025-08-31T15:14:18Z","publisher":"Institute of Science and Technology Austria","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","type":"research_data","status":"public","file":[{"date_created":"2025-08-31T15:09:44Z","success":1,"content_type":"application/zip","checksum":"055044b03f835cb98c45d0504f1db96e","file_id":"20244","relation":"main_file","access_level":"open_access","file_size":42368943,"date_updated":"2025-08-31T15:09:44Z","file_name":"Abstracts.zip","creator":"pschanda"},{"date_updated":"2025-08-31T15:11:58Z","file_name":"data_CO2_conferences.zip","file_size":470659,"access_level":"open_access","creator":"pschanda","success":1,"content_type":"application/zip","date_created":"2025-08-31T15:11:58Z","relation":"main_file","file_id":"20245","checksum":"1492683af736ac65088b77e12b52c3b0"},{"checksum":"8ac69071f7508e77b5ca91fa5018339a","file_id":"20246","relation":"main_file","date_created":"2025-08-31T15:12:03Z","content_type":"application/zip","success":1,"creator":"pschanda","access_level":"open_access","date_updated":"2025-08-31T15:12:03Z","file_size":1138772,"file_name":"Figure6_predictions.zip"},{"creator":"pschanda","access_level":"open_access","file_name":"ExcelFileAnalysisCode.py","date_updated":"2025-08-31T15:12:07Z","file_size":6558,"file_id":"20247","checksum":"19b77db247feecdc36fbe6f68d94a76d","relation":"main_file","date_created":"2025-08-31T15:12:07Z","success":1,"content_type":"text/x-python-script"},{"access_level":"open_access","file_name":"emissions_spectrometers_and_Parisgoal.pdf","date_updated":"2025-08-31T15:12:11Z","file_size":1107467,"creator":"pschanda","date_created":"2025-08-31T15:12:11Z","content_type":"application/pdf","success":1,"file_id":"20248","checksum":"39655e28c6df523f4f9662dc58c94623","relation":"main_file"},{"access_level":"open_access","file_name":"README","date_updated":"2025-09-01T11:05:27Z","file_size":3994,"creator":"pschanda","date_created":"2025-09-01T11:05:27Z","content_type":"application/octet-stream","success":1,"file_id":"20263","checksum":"2e9a9460b3f2abe7e46179561a63492b","relation":"main_file"}],"citation":{"mla":"Schanda, Paul. Data of: “Quantifying the Carbon Footprint of Conference Travel: The Case of NMR Meetings.” Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20242.","chicago":"Schanda, Paul. “Data of: ‘Quantifying the Carbon Footprint of Conference Travel: The Case of NMR Meetings.’” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20242.","ista":"Schanda P. 2025. Data of: ‘Quantifying the carbon footprint of conference travel: the case of NMR meetings’, Institute of Science and Technology Austria, 10.15479/AT-ISTA-20242.","apa":"Schanda, P. (2025). Data of: “Quantifying the carbon footprint of conference travel: the case of NMR meetings.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20242","short":"P. Schanda, (2025).","ama":"Schanda P. Data of: “Quantifying the carbon footprint of conference travel: the case of NMR meetings.” 2025. doi:10.15479/AT-ISTA-20242","ieee":"P. Schanda, “Data of: ‘Quantifying the carbon footprint of conference travel: the case of NMR meetings.’” Institute of Science and Technology Austria, 2025."},"has_accepted_license":"1","contributor":[{"id":"D2761128-D73D-11E9-A1BF-BA0DE6697425","contributor_type":"researcher","last_name":"Ruzickova","first_name":"Natalia"},{"first_name":"Lucky","last_name":"Kapoor","contributor_type":"researcher","id":"84b9700b-15b2-11ec-abd3-831089e67615"},{"id":"4c665ce3-0016-11ec-bea0-e44de7a4fa3d","contributor_type":"researcher","last_name":"Leitner","first_name":"Valentin"},{"last_name":"Zivadinovic","contributor_type":"researcher","id":"68AA0E5A-AFDA-11E9-9994-141DE6697425","first_name":"Predrag"},{"last_name":"Sisak","contributor_type":"researcher","id":"44A03D04-AEA4-11E9-B225-EA2DE6697425","first_name":"Maria A"},{"contributor_type":"researcher","last_name":"Mweka","id":"2a69ab4b-896a-11ed-bdf8-cb8641cf2b21","first_name":"Cecelia N"},{"first_name":"Jeroen A","last_name":"Dobbelaere","contributor_type":"supervisor","id":"c15a5412-de82-11ed-b809-8dc1aa996e40"},{"id":"38DB5788-F248-11E8-B48F-1D18A9856A87","last_name":"Katsaros","contributor_type":"supervisor","orcid":"0000-0001-8342-202X","first_name":"Georgios"}],"file_date_updated":"2025-09-01T11:05:27Z","oa_version":"Published Version","abstract":[{"lang":"eng","text":"This repository contains calculations of carbon footprints of NMR conferences, as described in the article by \r\nLucky N. Kapoor, Natalia Ruzickova, Predrag Živadinović, Valentin Leitner, Maria Anna Sisak, Cecelia Mweka, Jeroen Dobbelaere, Georgios Katsaros, and Paul Schanda\r\nPublished in Magnetic Resonance, 2025."}],"doi":"10.15479/AT-ISTA-20242","title":"Data of: \"Quantifying the carbon footprint of conference travel: the case of NMR meetings\"","related_material":{"record":[{"id":"20664","relation":"used_in_publication","status":"public"}]},"department":[{"_id":"PaSc"}]}]