[{"pmid":1,"OA_place":"publisher","volume":44,"author":[{"last_name":"Xu","first_name":"Faqing","full_name":"Xu, Faqing"},{"full_name":"Yu, Yongqiang","first_name":"Yongqiang","last_name":"Yu"},{"last_name":"Guan","first_name":"Bin","full_name":"Guan, Bin","id":"56aad729-cca2-11ed-a45a-9b4138991a48"},{"full_name":"Xu, Tongda","last_name":"Xu","first_name":"Tongda"},{"last_name":"Xu","first_name":"Zhihong","full_name":"Xu, Zhihong"},{"full_name":"Xue, Hongwei","first_name":"Hongwei","last_name":"Xue"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis","publication_status":"published","external_id":{"isi":["001542038500001"],"pmid":["40714631"]},"abstract":[{"text":"Auxin regulates various aspects of plant growth and development by modulating the transcription of target genes through the degradation of auxin/indole-3-acetic acid (Aux/IAA) repressors via the 26S proteasome. Proteasome regulator 1 (PTRE1), a positive regulator of proteasome activity, has been implicated in auxin-mediated proteasome suppression; however, the mechanism by which auxin modulates PTRE1 function remains unclear. Here, we demonstrate that auxin promotes the interaction between germin-like protein 1 (GLP1) and PTRE1, facilitating PTRE1 retention at the plasma membrane. The relocation of PTRE1 results in reduced nuclear 26S proteasome activity, and thus the attenuated Aux/IAA degradation and altered Aux/IAA homeostasis, ultimately resulting in suppressed auxin-mediated transcriptional regulation. Our findings uncover a previously uncharacterized regulatory axis in auxin signaling that controls Aux/IAA protein stability, functioning alongside the TIR1- and TRANSMEMBRANE KINASE 1 (TMK1)-mediated pathways, and highlight the coordination of auxin signaling from the cell surface to the nucleus via auxin-induced PTRE1 relocation, which fine-tunes Aux/IAA protein homeostasis and auxin responses.","lang":"eng"}],"article_processing_charge":"Yes","license":"https://creativecommons.org/licenses/by-nc/4.0/","publication":"Cell Reports","doi":"10.1016/j.celrep.2025.116056","publication_identifier":{"eissn":["2211-1247"]},"issue":"8","article_number":"116056","date_created":"2025-08-04T13:39:11Z","year":"2025","ddc":["580"],"has_accepted_license":"1","file":[{"file_id":"20120","checksum":"3c43e040a4a7a65ec67ae1d2bb81261a","relation":"main_file","access_level":"open_access","file_size":24178018,"date_updated":"2025-08-05T06:15:09Z","date_created":"2025-08-05T06:15:09Z","content_type":"application/pdf","file_name":"2025_CellReports_Xu.pdf","creator":"dernst","success":1}],"quality_controlled":"1","scopus_import":"1","_id":"20116","type":"journal_article","acknowledgement":"The study was supported by the National Natural Science Foundation of China (NSFC; 32230011, 91954206, and 31721001). We thank Dr. Deli Lin (Shanghai Jiao Tong University) for kind help with the laser confocal microscope observation and the Arabidopsis Biological Resource Center (ABRC) for providing T-DNA insertional mutants.","oa_version":"Published Version","intvolume":"        44","article_type":"original","date_updated":"2025-09-30T14:13:45Z","department":[{"_id":"JiFr"}],"publisher":"Elsevier","date_published":"2025-07-24T00:00:00Z","language":[{"iso":"eng"}],"month":"07","DOAJ_listed":"1","file_date_updated":"2025-08-05T06:15:09Z","oa":1,"isi":1,"day":"24","status":"public","tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"OA_type":"gold","citation":{"mla":"Xu, Faqing, et al. “Germin-like Protein 1 Interacts with Proteasome Regulator 1 to Regulate Auxin Signaling by Controlling Aux/IAA Homeostasis.” <i>Cell Reports</i>, vol. 44, no. 8, 116056, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.celrep.2025.116056\">10.1016/j.celrep.2025.116056</a>.","apa":"Xu, F., Yu, Y., Guan, B., Xu, T., Xu, Z., &#38; Xue, H. (2025). Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2025.116056\">https://doi.org/10.1016/j.celrep.2025.116056</a>","chicago":"Xu, Faqing, Yongqiang Yu, Bin Guan, Tongda Xu, Zhihong Xu, and Hongwei Xue. “Germin-like Protein 1 Interacts with Proteasome Regulator 1 to Regulate Auxin Signaling by Controlling Aux/IAA Homeostasis.” <i>Cell Reports</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.celrep.2025.116056\">https://doi.org/10.1016/j.celrep.2025.116056</a>.","ista":"Xu F, Yu Y, Guan B, Xu T, Xu Z, Xue H. 2025. Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis. Cell Reports. 44(8), 116056.","ama":"Xu F, Yu Y, Guan B, Xu T, Xu Z, Xue H. Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis. <i>Cell Reports</i>. 2025;44(8). doi:<a href=\"https://doi.org/10.1016/j.celrep.2025.116056\">10.1016/j.celrep.2025.116056</a>","short":"F. Xu, Y. Yu, B. Guan, T. Xu, Z. Xu, H. Xue, Cell Reports 44 (2025).","ieee":"F. Xu, Y. Yu, B. Guan, T. Xu, Z. Xu, and H. Xue, “Germin-like protein 1 interacts with proteasome regulator 1 to regulate auxin signaling by controlling Aux/IAA homeostasis,” <i>Cell Reports</i>, vol. 44, no. 8. Elsevier, 2025."}},{"PlanS_conform":"1","citation":{"ama":"Zhang Z, Todeschini TC, Wu Y, et al. Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. <i>Cell</i>. 2025;188(21):5862-5877.e23. doi:<a href=\"https://doi.org/10.1016/j.cell.2025.07.002\">10.1016/j.cell.2025.07.002</a>","ista":"Zhang Z, Todeschini TC, Wu Y, Kogay R, Naji A, Cardenas Rodriguez J, Mondi R, Kaganovich D, Taylor DW, Bravo JPK, Teplova M, Amen T, Koonin E, Patel DJ, Nobrega FL. 2025. Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. Cell. 188(21), 5862–5877.e23.","short":"Z. Zhang, T.C. Todeschini, Y. Wu, R. Kogay, A. Naji, J. Cardenas Rodriguez, R. Mondi, D. Kaganovich, D.W. Taylor, J.P.K. Bravo, M. Teplova, T. Amen, E. Koonin, D.J. Patel, F.L. Nobrega, Cell 188 (2025) 5862–5877.e23.","ieee":"Z. Zhang <i>et al.</i>, “Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites,” <i>Cell</i>, vol. 188, no. 21. Elsevier, p. 5862–5877.e23, 2025.","mla":"Zhang, Zhiying, et al. “Kiwa Is a Membrane-Embedded Defense Supercomplex Activated at Phage Attachment Sites.” <i>Cell</i>, vol. 188, no. 21, Elsevier, 2025, p. 5862–5877.e23, doi:<a href=\"https://doi.org/10.1016/j.cell.2025.07.002\">10.1016/j.cell.2025.07.002</a>.","chicago":"Zhang, Zhiying, Thomas C. Todeschini, Yi Wu, Roman Kogay, Ameena Naji, Joaquin Cardenas Rodriguez, Rupavidhya Mondi, et al. “Kiwa Is a Membrane-Embedded Defense Supercomplex Activated at Phage Attachment Sites.” <i>Cell</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.cell.2025.07.002\">https://doi.org/10.1016/j.cell.2025.07.002</a>.","apa":"Zhang, Z., Todeschini, T. C., Wu, Y., Kogay, R., Naji, A., Cardenas Rodriguez, J., … Nobrega, F. L. (2025). Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2025.07.002\">https://doi.org/10.1016/j.cell.2025.07.002</a>"},"OA_type":"hybrid","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","day":"16","oa":1,"file_date_updated":"2025-12-29T14:15:25Z","isi":1,"department":[{"_id":"JaBr"}],"publisher":"Elsevier","date_updated":"2025-12-29T14:15:58Z","language":[{"iso":"eng"}],"month":"10","date_published":"2025-10-16T00:00:00Z","acknowledgement":"We thank Rotem Sorek (Weizmann Institute of Science) for the Lambda Gam mutant and Ian Molineux (University of Texas) for T4Δgp2. We thank You Yu (Zhejiang University-University of Edinburgh Institute) and J. De La Cruz (MSK) for assistance with cryo-EM data collection and Lyuqin Zheng (MSK) for discussions on structural analysis. We thank the Imaging and Microscopy Centre (IMC) at the University of Southampton. This work was supported by Royal Society grant RGS\\R2\\222312 to F.L.N.; Welch Foundation grant F-1938 and National Institutes of Health R35GM138348 to D.W.T.; Wessex Medical Research Innovation grant AE06 to T.A.; and NIH grant GM145888 and Maloris Foundation and Memorial Sloan-Kettering Core grant (P30-CA008748) to D.J.P. In addition to MSKCC cryo-EM resources, some of this work was performed at the National Center for CryoEM Access and Training (NCCAT) and the Simons Electron Microscopy Center located at the New York Structural Biology Center, supported by the NIH Common Fund Transformative High Resolution Cryo-Electron Microscopy program (U24 GM129539) and Simons Foundation (SF349247) and NY State Assembly grants. This research used NSLS-II MX X-ray User Resources (FMX) of the National Synchrotron Light Source II, operated for the DOE Office of Science by Brookhaven National Laboratory under contract no. DE-SC0012704. The Center for BioMolecular Structure (CBMS) is primarily supported by the NIH, the National Institute of General Medical Sciences (NIGMS) through a Center Core P30 Grant (P30GM133893), and by the DOE Office of Biological and Environmental Research (KP1605010). R.K. and E.V.K. are supported by the Intramural Research Program of the NIH (National Library of Medicine).","type":"journal_article","article_type":"original","intvolume":"       188","oa_version":"Published Version","_id":"20143","scopus_import":"1","quality_controlled":"1","file":[{"access_level":"open_access","relation":"main_file","checksum":"b944de5fbd7455f58e1ff338ad352239","file_size":32104588,"date_updated":"2025-12-29T14:15:25Z","file_id":"20875","success":1,"creator":"dernst","date_created":"2025-12-29T14:15:25Z","content_type":"application/pdf","file_name":"2025_Cell_Zhang.pdf"}],"ddc":["570"],"has_accepted_license":"1","year":"2025","date_created":"2025-08-07T05:00:04Z","publication":"Cell","issue":"21","publication_identifier":{"issn":["0092-8674"],"eissn":["1097-4172"]},"doi":"10.1016/j.cell.2025.07.002","abstract":[{"text":"Bacteria and archaea deploy diverse antiviral defense systems, many of which remain mechanistically uncharacterized. Here, we characterize Kiwa, a widespread two-component system composed of the transmembrane sensor KwaA and the DNA-binding effector KwaB. Cryogenic electron microscopy (cryo-EM) analysis reveals that KwaA and KwaB assemble into a large, membrane-associated supercomplex. Upon phage binding, KwaA senses infection at the membrane, leading to KwaB binding of ejected phage DNA and inhibition of replication and late transcription, without inducing host cell death. Although KwaB can bind DNA independently, its antiviral activity requires association with KwaA, suggesting spatial or conformational regulation. We show that the phage-encoded DNA-mimic protein Gam directly binds and inhibits KwaB but that co-expression with the Gam-targeted RecBCD system restores protection by Kiwa. Our findings support a model in which Kiwa coordinates membrane-associated detection of phage infection with downstream DNA binding by its effector, forming a spatially coordinated antiviral mechanism.","lang":"eng"}],"publication_status":"published","external_id":{"pmid":["40730155"],"isi":["001603560700005"]},"page":"5862-5877.e23","article_processing_charge":"Yes (in subscription journal)","title":"Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites","volume":188,"OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Zhang","first_name":"Zhiying","full_name":"Zhang, Zhiying"},{"full_name":"Todeschini, Thomas C.","first_name":"Thomas C.","last_name":"Todeschini"},{"last_name":"Wu","first_name":"Yi","full_name":"Wu, Yi"},{"first_name":"Roman","last_name":"Kogay","full_name":"Kogay, Roman"},{"full_name":"Naji, Ameena","first_name":"Ameena","last_name":"Naji"},{"first_name":"Joaquin","last_name":"Cardenas Rodriguez","full_name":"Cardenas Rodriguez, Joaquin"},{"full_name":"Mondi, Rupavidhya","first_name":"Rupavidhya","last_name":"Mondi"},{"full_name":"Kaganovich, Daniel","last_name":"Kaganovich","first_name":"Daniel"},{"full_name":"Taylor, David W.","first_name":"David W.","last_name":"Taylor"},{"first_name":"Jack Peter Kelly","last_name":"Bravo","full_name":"Bravo, Jack Peter Kelly","orcid":"0000-0003-0456-0753","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e"},{"last_name":"Teplova","first_name":"Marianna","full_name":"Teplova, Marianna"},{"first_name":"Triana","last_name":"Amen","full_name":"Amen, Triana"},{"full_name":"Koonin, Eugene","last_name":"Koonin","first_name":"Eugene"},{"full_name":"Patel, Dinshaw J.","last_name":"Patel","first_name":"Dinshaw J."},{"full_name":"Nobrega, Franklin L.","last_name":"Nobrega","first_name":"Franklin L."}],"pmid":1},{"_id":"20146","type":"working_paper","OA_place":"publisher","author":[{"full_name":"Gredler, Paul","first_name":"Paul","last_name":"Gredler"},{"full_name":"Kaier, Christian","last_name":"Kaier","first_name":"Christian"},{"first_name":"Patrick","last_name":"Danowski","orcid":"0000-0002-6026-4409","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87","full_name":"Danowski, Patrick"},{"first_name":"Michael","last_name":"Zoyer","full_name":"Zoyer, Michael"},{"full_name":"Rieck, Katharina","first_name":"Katharina","last_name":"Rieck"},{"full_name":"Ferus, Andreas","last_name":"Ferus","first_name":"Andreas"},{"full_name":"Rosenberger, Elisabeth","last_name":"Rosenberger","first_name":"Elisabeth"},{"last_name":"Löffler","first_name":"Alexander","full_name":"Löffler, Alexander"},{"full_name":"Hofer, Lisa","last_name":"Hofer","first_name":"Lisa"},{"first_name":"Laura","last_name":"Still","full_name":"Still, Laura"}],"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-08-11T07:20:03Z","publisher":"Zenodo","department":[{"_id":"E-Lib"}],"date_published":"2025-08-07T00:00:00Z","month":"08","language":[{"iso":"eng"}],"title":"Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures","publication_status":"published","abstract":[{"lang":"eng","text":"This criteria catalogue and the accompanying assessment questions were developed by a working group of KEMÖ (Kooperation E-Medien Österreich, the Austrian Academic Library Consortium). They are intended to support research institutions and organisations in the evaluation of Open Science Infrastructures. The 20 criteria outlined in the catalogue provide a structured basis for making informed decisions regarding the financial support of these infrastructures.\r\n\r\nThe assessment questions are intended to be completed by Open Science Infrastructures and can be shared with them accordingly."}],"oa":1,"article_processing_charge":"No","status":"public","day":"07","doi":"10.5281/zenodo.15269364","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"OA_type":"gold","date_created":"2025-08-07T11:10:14Z","year":"2025","ddc":["020"],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5281/zenodo.15269364"}],"has_accepted_license":"1","citation":{"ama":"Gredler P, Kaier C, Danowski P, et al. <i>Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures</i>. Zenodo; 2025. doi:<a href=\"https://doi.org/10.5281/zenodo.15269364\">10.5281/zenodo.15269364</a>","ista":"Gredler P, Kaier C, Danowski P, Zoyer M, Rieck K, Ferus A, Rosenberger E, Löffler A, Hofer L, Still L. 2025. Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures, Zenodo,p.","ieee":"P. Gredler <i>et al.</i>, <i>Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures</i>. Zenodo, 2025.","short":"P. Gredler, C. Kaier, P. Danowski, M. Zoyer, K. Rieck, A. Ferus, E. Rosenberger, A. Löffler, L. Hofer, L. Still, Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures, Zenodo, 2025.","mla":"Gredler, Paul, et al. <i>Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures</i>. Zenodo, 2025, doi:<a href=\"https://doi.org/10.5281/zenodo.15269364\">10.5281/zenodo.15269364</a>.","apa":"Gredler, P., Kaier, C., Danowski, P., Zoyer, M., Rieck, K., Ferus, A., … Still, L. (2025). <i>Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures</i>. Zenodo. <a href=\"https://doi.org/10.5281/zenodo.15269364\">https://doi.org/10.5281/zenodo.15269364</a>","chicago":"Gredler, Paul, Christian Kaier, Patrick Danowski, Michael Zoyer, Katharina Rieck, Andreas Ferus, Elisabeth Rosenberger, Alexander Löffler, Lisa Hofer, and Laura Still. <i>Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures</i>. Zenodo, 2025. <a href=\"https://doi.org/10.5281/zenodo.15269364\">https://doi.org/10.5281/zenodo.15269364</a>."}},{"publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-20149","year":"2025","date_created":"2025-08-08T09:18:02Z","ddc":["570"],"has_accepted_license":"1","file":[{"file_id":"20232","file_size":63885565,"date_updated":"2025-08-27T12:59:10Z","relation":"main_file","checksum":"fda8a1070667c3562263f4867609b41b","access_level":"open_access","file_name":"2025_ReisRodrigues_Patricia_Thesis.pdf","content_type":"application/pdf","date_created":"2025-08-27T12:59:10Z","creator":"prodrigu","success":1},{"creator":"prodrigu","date_created":"2025-08-27T13:00:30Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"2025_ReisRodrigues_Patricia_Thesis.docx","relation":"source_file","checksum":"e8b65affcbce846a926454df4b2867b9","access_level":"closed","file_size":50483434,"date_updated":"2025-08-27T13:02:28Z","file_id":"20233"}],"corr_author":"1","related_material":{"record":[{"status":"public","id":"10703","relation":"part_of_dissertation"},{"status":"public","id":"20082","relation":"part_of_dissertation"}]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"NanoFab"}],"OA_place":"publisher","author":[{"full_name":"Dos Reis Rodrigues, Patricia","id":"26E95904-5160-11E9-9C0B-C5B0DC97E90F","orcid":"0000-0003-1681-508X","first_name":"Patricia","last_name":"Dos Reis Rodrigues"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Coordination of protrusive forces in immune cell migration ","degree_awarded":"PhD","supervisor":[{"full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","last_name":"Sixt","first_name":"Michael K"}],"abstract":[{"lang":"eng","text":"Immune responses depend on the coordinated and efficient migration of leukocytes. These\r\ncells, which are embedded and tightly confined within tissues, must navigate and traverse\r\ndiverse and complex three-dimensional environments. Leukocytes adapt their locomotory\r\nbehavior to the mechanical, geometrical, and biochemical characteristics of their\r\nsurroundings. In low-density environments, where the pore size of the interstitial matrix\r\nallows free passage, these cells position the nucleus directly behind the lamellipodium, the\r\nprotrusive actin structure that forms the leading front of the cell. In this configuration, they\r\nuse the nucleus as a gauge to identify the path of least resistance.\r\nHere, we show that in high-density environments, where the pore size precludes free passage\r\nof the cell body, leukocytes reposition the microtubule-organizing center (MTOC) and\r\nassociated organelles in front of the nucleus. In this configuration, they use actin structures\r\nprotruding orthogonally to the direction of migration in order to open a path for the cell body.\r\nWe identify two distinct actin populations that serve this purpose at different subcellular\r\nlocalizations. At the leading edge, local indentation of the plasma membrane leads to\r\nrecruitment of the Wiskott-Aldrich syndrome protein (WASp), which, via Arp2/3, results in\r\nthe formation of individual actin foci. At the cell body, actin polymerization is triggered by\r\nDOCK8, a Cdc42 exchange factor, resulting in the formation of a central actin pool.\r\nWe demonstrate that the central and peripheral actin pools are functionally communicating\r\nand that depletion of the central actin pool leads to increased actin accumulation at the cell\r\nfront, resulting in excessive extension of the leading edge."}],"publication_status":"published","page":"114","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","article_processing_charge":"No","day":"08","status":"public","alternative_title":["ISTA Thesis"],"tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"project":[{"grant_number":"101071793","_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces"}],"citation":{"ista":"Dos Reis Rodrigues P. 2025. Coordination of protrusive forces in immune cell migration . Institute of Science and Technology Austria.","ama":"Dos Reis Rodrigues P. Coordination of protrusive forces in immune cell migration . 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20149\">10.15479/AT-ISTA-20149</a>","short":"P. Dos Reis Rodrigues, Coordination of Protrusive Forces in Immune Cell Migration , Institute of Science and Technology Austria, 2025.","ieee":"P. Dos Reis Rodrigues, “Coordination of protrusive forces in immune cell migration ,” Institute of Science and Technology Austria, 2025.","mla":"Dos Reis Rodrigues, Patricia. <i>Coordination of Protrusive Forces in Immune Cell Migration </i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20149\">10.15479/AT-ISTA-20149</a>.","apa":"Dos Reis Rodrigues, P. (2025). <i>Coordination of protrusive forces in immune cell migration </i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20149\">https://doi.org/10.15479/AT-ISTA-20149</a>","chicago":"Dos Reis Rodrigues, Patricia. “Coordination of Protrusive Forces in Immune Cell Migration .” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20149\">https://doi.org/10.15479/AT-ISTA-20149</a>."},"_id":"20149","type":"dissertation","acknowledgement":"I would like to acknowledge the\r\nfinancial support of the European Research Council through the ERC-SyG grant “Pushing from\r\nwithin: Control of cell shape, integrity and motility by cytoskeletal pushing forces”\r\n(01071793), which made this research possible. ","oa_version":"Published Version","department":[{"_id":"GradSch"},{"_id":"MiSi"}],"publisher":"Institute of Science and Technology Austria","date_updated":"2026-04-28T13:26:50Z","month":"08","language":[{"iso":"eng"}],"date_published":"2025-08-08T00:00:00Z","oa":1,"file_date_updated":"2025-08-27T13:02:28Z"},{"ddc":["570"],"has_accepted_license":"1","quality_controlled":"1","file":[{"file_id":"20873","file_size":327847,"date_updated":"2025-12-29T13:47:27Z","access_level":"open_access","relation":"main_file","checksum":"90942491b499f70b0bf48b8aec2e7387","content_type":"application/pdf","file_name":"2025_TrendsNeurosciences_Hetzer.pdf","date_created":"2025-12-29T13:47:27Z","success":1,"creator":"dernst"}],"corr_author":"1","publication":"Trends in Neurosciences","issue":"9","doi":"10.1016/j.tins.2025.07.004","publication_identifier":{"issn":["0166-2236"],"eissn":["1878-108X"]},"year":"2025","date_created":"2025-08-10T22:01:29Z","title":"Long-lived cellular molecules in the brain","abstract":[{"text":"In long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellular identity and plasticity to preserve brain function. Although extensive studies indicate the importance of recycling and regenerating cellular molecules to maintain cellular homeostasis, recent evidence has shown that some proteins and RNAs do not turn over for months and even years. We propose that these long-lived cellular molecules may be the basis for maintaining brain function in the long term, but also a potential convergent target of brain aging. We highlight key discoveries and challenges, and propose potential directions to unravel the mystery of brain cell longevity.","lang":"eng"}],"publication_status":"published","external_id":{"isi":["001568965400001"],"pmid":["40744775"]},"page":"645-654","article_processing_charge":"Yes (in subscription journal)","pmid":1,"OA_place":"publisher","volume":48,"author":[{"last_name":"Hetzer","first_name":"Martin W","full_name":"Hetzer, Martin W","orcid":"0000-0002-2111-992X","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"},{"first_name":"Tomohisa","last_name":"Toda","full_name":"Toda, Tomohisa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","PlanS_conform":"1","citation":{"ieee":"M. Hetzer and T. Toda, “Long-lived cellular molecules in the brain,” <i>Trends in Neurosciences</i>, vol. 48, no. 9. Elsevier, pp. 645–654, 2025.","short":"M. Hetzer, T. Toda, Trends in Neurosciences 48 (2025) 645–654.","ista":"Hetzer M, Toda T. 2025. Long-lived cellular molecules in the brain. Trends in Neurosciences. 48(9), 645–654.","ama":"Hetzer M, Toda T. Long-lived cellular molecules in the brain. <i>Trends in Neurosciences</i>. 2025;48(9):645-654. doi:<a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">10.1016/j.tins.2025.07.004</a>","apa":"Hetzer, M., &#38; Toda, T. (2025). Long-lived cellular molecules in the brain. <i>Trends in Neurosciences</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">https://doi.org/10.1016/j.tins.2025.07.004</a>","chicago":"Hetzer, Martin, and Tomohisa Toda. “Long-Lived Cellular Molecules in the Brain.” <i>Trends in Neurosciences</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">https://doi.org/10.1016/j.tins.2025.07.004</a>.","mla":"Hetzer, Martin, and Tomohisa Toda. “Long-Lived Cellular Molecules in the Brain.” <i>Trends in Neurosciences</i>, vol. 48, no. 9, Elsevier, 2025, pp. 645–54, doi:<a href=\"https://doi.org/10.1016/j.tins.2025.07.004\">10.1016/j.tins.2025.07.004</a>."},"day":"01","status":"public","OA_type":"hybrid","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"MaHe"}],"publisher":"Elsevier","date_updated":"2025-12-29T13:47:58Z","month":"09","language":[{"iso":"eng"}],"date_published":"2025-09-01T00:00:00Z","oa":1,"file_date_updated":"2025-12-29T13:47:27Z","isi":1,"_id":"20154","scopus_import":"1","acknowledgement":"The work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (470322152 – T1347/3-1; 497658532 – T1347/4-1; 507965872 – T1347/5-1; and 460333672 – CRC1540 Exploring Brain Mechanics) to T.T., the Schram Foundation (T.T.), the European Research Council (ERC-2018-STG, 804468 EAGER; ERC-2023-COG, 101125034 NEUTIME) to T.T., the Hans-Georg Geis und Xue Hong Dong-Geis Foundation and Forschungsstiftung Medizin am Universitätsklinikum Erlangen to T.T., and the Interdisciplinary Centre for Clinical Research Erlangen (Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Erlangen; P162 to T.T.). We thank Dr Laura J. Harrison for editing assistance.","type":"journal_article","article_type":"original","intvolume":"        48","oa_version":"Published Version"},{"publication":"SIAM Journal on Mathematical Analysis","issue":"4","doi":"10.1137/24M1700351","publication_identifier":{"issn":["0036-1410"],"eissn":["1095-7154"]},"year":"2025","date_created":"2025-08-10T22:01:29Z","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2302.14506","open_access":"1"}],"quality_controlled":"1","corr_author":"1","volume":57,"OA_place":"repository","author":[{"first_name":"Giovanni","last_name":"Brigati","id":"63ff57e8-1fbb-11ee-88f2-f558ffc59cf1","full_name":"Brigati, Giovanni"},{"full_name":"Stoltz, Gabriel","last_name":"Stoltz","first_name":"Gabriel"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"How to construct explicit decay rates for kinetic Fokker–Planck equations?","abstract":[{"lang":"eng","text":"We study time averages for the norm of solutions to kinetic Fokker–Planck equations associated with general Hamiltonians. We provide fully explicit and constructive decay estimates for systems subject to a confining potential, allowing fat-tail, subexponential and (super-)exponential local equilibria, which also include the classic Maxwellian case. The key step in our estimates is a modified Poincaré inequality, obtained via a Lions–Poincaré inequality and an averaging lemma."}],"external_id":{"isi":["001550830900006"],"arxiv":["2302.14506"]},"publication_status":"published","page":"3587-3622","article_processing_charge":"No","day":"01","status":"public","OA_type":"green","ec_funded":1,"project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program"}],"citation":{"mla":"Brigati, Giovanni, and Gabriel Stoltz. “How to Construct Explicit Decay Rates for Kinetic Fokker–Planck Equations?” <i>SIAM Journal on Mathematical Analysis</i>, vol. 57, no. 4, Society for Industrial and Applied Mathematics, 2025, pp. 3587–622, doi:<a href=\"https://doi.org/10.1137/24M1700351\">10.1137/24M1700351</a>.","apa":"Brigati, G., &#38; Stoltz, G. (2025). How to construct explicit decay rates for kinetic Fokker–Planck equations? <i>SIAM Journal on Mathematical Analysis</i>. Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/24M1700351\">https://doi.org/10.1137/24M1700351</a>","chicago":"Brigati, Giovanni, and Gabriel Stoltz. “How to Construct Explicit Decay Rates for Kinetic Fokker–Planck Equations?” <i>SIAM Journal on Mathematical Analysis</i>. Society for Industrial and Applied Mathematics, 2025. <a href=\"https://doi.org/10.1137/24M1700351\">https://doi.org/10.1137/24M1700351</a>.","ama":"Brigati G, Stoltz G. How to construct explicit decay rates for kinetic Fokker–Planck equations? <i>SIAM Journal on Mathematical Analysis</i>. 2025;57(4):3587-3622. doi:<a href=\"https://doi.org/10.1137/24M1700351\">10.1137/24M1700351</a>","ista":"Brigati G, Stoltz G. 2025. How to construct explicit decay rates for kinetic Fokker–Planck equations? SIAM Journal on Mathematical Analysis. 57(4), 3587–3622.","short":"G. Brigati, G. Stoltz, SIAM Journal on Mathematical Analysis 57 (2025) 3587–3622.","ieee":"G. Brigati and G. Stoltz, “How to construct explicit decay rates for kinetic Fokker–Planck equations?,” <i>SIAM Journal on Mathematical Analysis</i>, vol. 57, no. 4. Society for Industrial and Applied Mathematics, pp. 3587–3622, 2025."},"_id":"20155","scopus_import":"1","type":"journal_article","acknowledgement":"The first author was funded by the European Union's Horizon 2020 research andinnovation program under the Marie Sklodowska-Curie grant agreements 754362 and 101034413,and partially by Project EFI (ANR-17-CE40-0030) of the French National Research Agency (ANR).The work of the second author was partially funded by the European Research Council (ERC) underthe European Union's Horizon 2020 research and innovation programme (grant agreement 810367),and by the Agence Nationale de la Recherche under grants ANR-19-CE40-0010 (QuAMProcs) andANR-21-CE40-0006 (SINEQ).","article_type":"original","oa_version":"Preprint","intvolume":"        57","department":[{"_id":"JaMa"}],"arxiv":1,"publisher":"Society for Industrial and Applied Mathematics","date_updated":"2025-11-05T13:51:40Z","month":"08","language":[{"iso":"eng"}],"date_published":"2025-08-01T00:00:00Z","oa":1,"isi":1},{"year":"2025","date_created":"2025-08-17T22:01:35Z","article_number":"101411","doi":"10.1016/j.cois.2025.101411","publication_identifier":{"eissn":["2214-5753"],"issn":["2214-5745"]},"publication":"Current Opinion in Insect Science","corr_author":"1","quality_controlled":"1","file":[{"file_name":"2025_CurrOpinionInsectScience_Toups.pdf","content_type":"application/pdf","date_created":"2025-12-30T13:14:20Z","success":1,"creator":"dernst","file_id":"20917","date_updated":"2025-12-30T13:14:20Z","file_size":897079,"access_level":"open_access","checksum":"262640abc34277686b56eb60102976f6","relation":"main_file"}],"has_accepted_license":"1","ddc":["570"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Toups","first_name":"Melissa A","orcid":"0000-0002-9752-7380","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","full_name":"Toups, Melissa A"},{"last_name":"Vicoso","first_name":"Beatriz","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz"}],"OA_place":"publisher","volume":72,"article_processing_charge":"Yes (via OA deal)","abstract":[{"text":"Sex chromosomes have evolved many times throughout the tree of life, and understanding what has shaped their unusual morphological, sequence, and regulatory features has been a long-standing goal. Most early insights into insect sex chromosome biology came from a few model species, such as the fruit fly Drosophila melanogaster, which limited broad-scale evolutionary inferences. More recently, extensive comparative genomics studies have uncovered several unexpected patterns, which we highlight in this review. First, we describe the conservation of the ancestral X chromosome over 450 million years but also its recurrent turnover (i.e. its reversal to an autosome when a new X chromosome arose) in at least one order. We then summarize classical and more recent findings on how insects modulate the expression of X-linked genes following the degradation of the Y chromosome and how the diverse mechanisms of dosage compensation identified may elucidate important principles of sex chromosome regulatory evolution.","lang":"eng"}],"publication_status":"published","external_id":{"isi":["001582424100001"]},"title":"Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation","OA_type":"hybrid","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"day":"01","status":"public","PlanS_conform":"1","citation":{"apa":"Toups, M. A., &#38; Vicoso, B. (2025). Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>","chicago":"Toups, Melissa A, and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>.","mla":"Toups, Melissa A., and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>, vol. 72, 101411, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>.","short":"M.A. Toups, B. Vicoso, Current Opinion in Insect Science 72 (2025).","ieee":"M. A. Toups and B. Vicoso, “Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation,” <i>Current Opinion in Insect Science</i>, vol. 72. Elsevier, 2025.","ista":"Toups MA, Vicoso B. 2025. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. Current Opinion in Insect Science. 72, 101411.","ama":"Toups MA, Vicoso B. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. 2025;72. doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>"},"project":[{"name":"Sex chromosomes in evolution and development","_id":"8ed82125-16d5-11f0-9cad-fbcae312235b","grant_number":"PAT 8748323"}],"article_type":"review","oa_version":"Published Version","intvolume":"        72","acknowledgement":"This work was supported by an Austrian Research Fund (FWF) grant to B.V. (PAT 8748323) and by the Louisiana Board of Regents Research Competitiveness Subprogram (LEQSF(2025-28)-RD-A-20) to MAT.","type":"journal_article","_id":"20182","scopus_import":"1","isi":1,"oa":1,"file_date_updated":"2025-12-30T13:14:20Z","month":"12","language":[{"iso":"eng"}],"date_published":"2025-12-01T00:00:00Z","department":[{"_id":"BeVi"}],"publisher":"Elsevier","date_updated":"2025-12-30T13:14:38Z"},{"publisher":"Springer Nature","department":[{"_id":"CaHe"}],"date_updated":"2025-09-01T09:47:29Z","month":"08","language":[{"iso":"eng"}],"date_published":"2025-08-04T00:00:00Z","oa":1,"file_date_updated":"2025-09-01T09:46:44Z","DOAJ_listed":"1","_id":"20183","scopus_import":"1","type":"journal_article","acknowledgement":"We thank members of the Conradt lab, the Center for Cell and Molecular Dynamics (https://www.uclccmd.co.uk/) and T. Schedl for discussions and comments on the manuscript. We thank L. McGuinness for excellent technical support. Some strains were provided by the Caenorhabditis Genetics Center (CGC), which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We thank Alex Hajnal (University of Zurich, Switzerland) and Andrew deMello (ETH Zurich, Switzerland) for their support of S.B. This work was supported by a predoctoral fellowship from the Studienstiftung des deutschen Volkes to NM, funds from UCL (Division of Biosciences, UCL LSM Capital Equipment Fund) to B.C., and a Wolfson Fellowship from the Royal Society (https://royalsociety.org/) to B.C. (RSWF\\R1\\180008), and the Biotechnology and Biological Sciences Research Council (https://bbsrc.ukri.org/) (BB/V007572/1 and BB/V015648/1to B.C.).","article_type":"original","oa_version":"Published Version","intvolume":"        16","PlanS_conform":"1","citation":{"ama":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-62484-5\">10.1038/s41467-025-62484-5</a>","ista":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. 2025. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. Nature Communications. 16, 7174.","ieee":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E. J. Lambie, and B. Conradt, “Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","short":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E.J. Lambie, B. Conradt, Nature Communications 16 (2025).","mla":"Segos, Ioannis, et al. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” <i>Nature Communications</i>, vol. 16, 7174, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-62484-5\">10.1038/s41467-025-62484-5</a>.","chicago":"Segos, Ioannis, Jens Van Eeckhoven, Simon Berger, Nikhil Mishra, Eric J. Lambie, and Barbara Conradt. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-62484-5\">https://doi.org/10.1038/s41467-025-62484-5</a>.","apa":"Segos, I., Van Eeckhoven, J., Berger, S., Mishra, N., Lambie, E. J., &#38; Conradt, B. (2025). Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-62484-5\">https://doi.org/10.1038/s41467-025-62484-5</a>"},"day":"04","status":"public","OA_type":"gold","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"title":"Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo","abstract":[{"text":"The unequal segregation of organelles has been proposed to be an intrinsic mechanism that contributes to cell fate divergence during asymmetric cell division; however, in vivo evidence is sparse. Using super-resolution microscopy, we analysed the segregation of organelles during the division of the neuroblast QL.p in C. elegans larvae. QL.p divides to generate a daughter that survives, QL.pa, and a daughter that dies, QL.pp. We found that mitochondria segregate unequally by density and morphology and that this is dependent on mitochondrial dynamics. Furthermore, we found that mitochondrial density in QL.pp correlates with the time it takes QL.pp to die. We propose that low mitochondrial density in QL.pp promotes the cell death fate and ensures that QL.pp dies in a highly reproducible and timely manner. Our results provide in vivo evidence that the unequal segregation of mitochondria can contribute to cell fate divergence during asymmetric cell division in a developing animal.","lang":"eng"}],"external_id":{"pmid":["40759648"]},"publication_status":"published","article_processing_charge":"Yes","pmid":1,"volume":16,"OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Segos","first_name":"Ioannis","full_name":"Segos, Ioannis"},{"full_name":"Van Eeckhoven, Jens","first_name":"Jens","last_name":"Van Eeckhoven"},{"last_name":"Berger","first_name":"Simon","full_name":"Berger, Simon"},{"id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","orcid":"0000-0002-6425-5788","full_name":"Mishra, Nikhil","last_name":"Mishra","first_name":"Nikhil"},{"last_name":"Lambie","first_name":"Eric J.","full_name":"Lambie, Eric J."},{"first_name":"Barbara","last_name":"Conradt","full_name":"Conradt, Barbara"}],"ddc":["570"],"has_accepted_license":"1","quality_controlled":"1","file":[{"content_type":"application/pdf","file_name":"2025_NatureComm_Segos.pdf","date_created":"2025-09-01T09:46:44Z","success":1,"creator":"dernst","file_id":"20261","date_updated":"2025-09-01T09:46:44Z","file_size":3775190,"access_level":"open_access","checksum":"f28e73963ea1f55876d0d1afca0f706a","relation":"main_file"}],"publication":"Nature Communications","publication_identifier":{"eissn":["2041-1723"]},"doi":"10.1038/s41467-025-62484-5","article_number":"7174","year":"2025","date_created":"2025-08-17T22:01:35Z"},{"date_created":"2025-08-17T22:01:35Z","year":"2025","article_number":"1148","publication_identifier":{"eissn":["2399-3642"]},"doi":"10.1038/s42003-025-08589-5","publication":"Communications Biology","quality_controlled":"1","main_file_link":[{"url":"https://doi.org/10.1038/s42003-025-08589-5","open_access":"1"}],"has_accepted_license":"1","ddc":["570"],"author":[{"full_name":"Castell, Sofía D.","first_name":"Sofía D.","last_name":"Castell"},{"full_name":"Fernandez, Consuelo M.","first_name":"Consuelo M.","last_name":"Fernandez"},{"full_name":"Tumas, Ignacio N.","first_name":"Ignacio N.","last_name":"Tumas"},{"first_name":"Lucía M.","last_name":"Margara","full_name":"Margara, Lucía M."},{"last_name":"Miserendino","first_name":"Maria C","id":"273e0cbd-72f0-11ef-b75a-f9f932e292fa","full_name":"Miserendino, Maria C"},{"last_name":"Ceschin","first_name":"Danilo G.","full_name":"Ceschin, Danilo G."},{"full_name":"Pezza, Roberto J.","last_name":"Pezza","first_name":"Roberto J."},{"full_name":"Monti, Mariela R.","first_name":"Mariela R.","last_name":"Monti"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","OA_place":"publisher","volume":8,"pmid":1,"article_processing_charge":"Yes","publication_status":"published","external_id":{"pmid":["40753298"],"isi":["001541878500001"]},"abstract":[{"lang":"eng","text":"Specialized DNA polymerases facilitate various cellular processes. Despite extensive research, the mutagenic effects of these error-prone enzymes on genomes are not fully understood. Here we show that Pol IV promotes genomic instability in Pseudomonas aeruginosa by misincorporating oxidized guanine nucleotides. This activity led to a distinctive mutational signature, characterized by A-to-C transversions occurring preferentially at AT sites flanked by a 5’G and/or 3’C. Furthermore, Pol IV preferentially targeted pathogenicity genes located at specific chromosomal locations near the replication termination region and rRNA-encoding operons. Half of the mutation events catalyzed by Pol IV impaired gene function. This can be attributed to the bias of Pol IV for mutating codons with its preferred sequence contexts, leading to substitutions to unreactive alanine and glycine residues. Remarkably, mutation signatures identified for Pol IV were found in clinical isolate genomes of P. aeruginosa, providing compelling evidence for its role in genetic diversification during pathogen adaptation."}],"title":"The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"OA_type":"gold","status":"public","day":"02","citation":{"apa":"Castell, S. D., Fernandez, C. M., Tumas, I. N., Margara, L. M., Miserendino, M. C., Ceschin, D. G., … Monti, M. R. (2025). The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-025-08589-5\">https://doi.org/10.1038/s42003-025-08589-5</a>","chicago":"Castell, Sofía D., Consuelo M. Fernandez, Ignacio N. Tumas, Lucía M. Margara, Maria C Miserendino, Danilo G. Ceschin, Roberto J. Pezza, and Mariela R. Monti. “The Low-Fidelity DNA Pol IV Accelerates Evolution of Pathogenicity Genes in Pseudomonas Aeruginosa.” <i>Communications Biology</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s42003-025-08589-5\">https://doi.org/10.1038/s42003-025-08589-5</a>.","mla":"Castell, Sofía D., et al. “The Low-Fidelity DNA Pol IV Accelerates Evolution of Pathogenicity Genes in Pseudomonas Aeruginosa.” <i>Communications Biology</i>, vol. 8, 1148, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s42003-025-08589-5\">10.1038/s42003-025-08589-5</a>.","short":"S.D. Castell, C.M. Fernandez, I.N. Tumas, L.M. Margara, M.C. Miserendino, D.G. Ceschin, R.J. Pezza, M.R. Monti, Communications Biology 8 (2025).","ieee":"S. D. Castell <i>et al.</i>, “The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa,” <i>Communications Biology</i>, vol. 8. Springer Nature, 2025.","ama":"Castell SD, Fernandez CM, Tumas IN, et al. The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. <i>Communications Biology</i>. 2025;8. doi:<a href=\"https://doi.org/10.1038/s42003-025-08589-5\">10.1038/s42003-025-08589-5</a>","ista":"Castell SD, Fernandez CM, Tumas IN, Margara LM, Miserendino MC, Ceschin DG, Pezza RJ, Monti MR. 2025. The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. Communications Biology. 8, 1148."},"PlanS_conform":"1","intvolume":"         8","oa_version":"Published Version","article_type":"original","type":"journal_article","acknowledgement":"This work was supported by the Secretaría de Ciencia y Técnica (33620230100926CB), Universidad Nacional de Córdoba; and the Agencia Nacional de Promoción Científica y Técnica (PICT 2018-4527).\r\n\r\n","scopus_import":"1","_id":"20184","isi":1,"DOAJ_listed":"1","oa":1,"date_published":"2025-08-02T00:00:00Z","language":[{"iso":"eng"}],"month":"08","date_updated":"2025-09-30T14:18:46Z","publisher":"Springer Nature","department":[{"_id":"PaSc"},{"_id":"GradSch"}]},{"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ec_funded":1,"OA_type":"hybrid","status":"public","day":"07","citation":{"short":"D. Tsodikovich, Journal of Geometric Analysis 35 (2025).","ieee":"D. Tsodikovich, “Local rigidity for symplectic billiards,” <i>Journal of Geometric Analysis</i>, vol. 35, no. 10. Springer Nature, 2025.","ama":"Tsodikovich D. Local rigidity for symplectic billiards. <i>Journal of Geometric Analysis</i>. 2025;35(10). doi:<a href=\"https://doi.org/10.1007/s12220-025-02148-4\">10.1007/s12220-025-02148-4</a>","ista":"Tsodikovich D. 2025. Local rigidity for symplectic billiards. Journal of Geometric Analysis. 35(10), 306.","apa":"Tsodikovich, D. (2025). Local rigidity for symplectic billiards. <i>Journal of Geometric Analysis</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s12220-025-02148-4\">https://doi.org/10.1007/s12220-025-02148-4</a>","chicago":"Tsodikovich, Daniel. “Local Rigidity for Symplectic Billiards.” <i>Journal of Geometric Analysis</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s12220-025-02148-4\">https://doi.org/10.1007/s12220-025-02148-4</a>.","mla":"Tsodikovich, Daniel. “Local Rigidity for Symplectic Billiards.” <i>Journal of Geometric Analysis</i>, vol. 35, no. 10, 306, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1007/s12220-025-02148-4\">10.1007/s12220-025-02148-4</a>."},"PlanS_conform":"1","project":[{"call_identifier":"H2020","name":"Spectral rigidity and integrability for billiards and geodesic flows","_id":"9B8B92DE-BA93-11EA-9121-9846C619BF3A","grant_number":"885707"}],"intvolume":"        35","oa_version":"Published Version","article_type":"original","type":"journal_article","acknowledgement":"The author would like to thank Corentin Fierobe, Vadim Kaloshin, Illya Koval and Yunzhe Li for useful discussions. The author would also like to thank the referee for useful remarks. Open access funding provided by Institute of Science and Technology (IST Austria). European Research Council (885707) Mr Daniel Tsodikovich","scopus_import":"1","_id":"20185","isi":1,"file_date_updated":"2025-12-30T09:28:58Z","oa":1,"date_published":"2025-08-07T00:00:00Z","month":"08","language":[{"iso":"eng"}],"date_updated":"2025-12-30T09:29:27Z","publisher":"Springer Nature","arxiv":1,"department":[{"_id":"VaKa"}],"date_created":"2025-08-17T22:01:35Z","year":"2025","article_number":"306","publication_identifier":{"issn":["1050-6926"]},"doi":"10.1007/s12220-025-02148-4","issue":"10","publication":"Journal of Geometric Analysis","corr_author":"1","quality_controlled":"1","file":[{"date_created":"2025-12-30T09:28:58Z","content_type":"application/pdf","file_name":"2025_JourGeomAnalysis_Tsodikovich.pdf","creator":"dernst","success":1,"file_id":"20907","checksum":"ed86500742b3fd93db3287558a630383","relation":"main_file","access_level":"open_access","date_updated":"2025-12-30T09:28:58Z","file_size":484344}],"has_accepted_license":"1","ddc":["510"],"author":[{"last_name":"Tsodikovich","first_name":"Daniel","id":"04531810-fb3e-11ef-87f0-800a4ce333db","full_name":"Tsodikovich, Daniel"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","volume":35,"article_processing_charge":"Yes (via OA deal)","publication_status":"published","external_id":{"arxiv":["2501.08849"],"isi":["001546433200002"]},"abstract":[{"text":"We show a local rigidity result for the integrability of symplectic billiards. We prove that any domain which is close to an ellipse, and for which the symplectic billiard map is rationally integrable must be an ellipse as well. This is in spirit of the result of [2] for Birkhoff billiards.","lang":"eng"}],"title":"Local rigidity for symplectic billiards"},{"OA_place":"publisher","volume":62,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","author":[{"full_name":"Hsu, Tzu Han","last_name":"Hsu","first_name":"Tzu Han"},{"first_name":"Ana A","last_name":"Oliveira Da Costa","id":"8b282559-50b0-11ef-861e-d6ace0d92e9b","full_name":"Oliveira Da Costa, Ana A"},{"full_name":"Wintenberg, Andrew","first_name":"Andrew","last_name":"Wintenberg"},{"full_name":"Bartocci, Ezio","first_name":"Ezio","last_name":"Bartocci"},{"first_name":"Borzoo","last_name":"Bonakdarpour","full_name":"Bonakdarpour, Borzoo"}],"external_id":{"isi":["001546115300001"]},"publication_status":"published","abstract":[{"text":"Enforcement of information-flow policies has been extensively studied by language-based approaches over the past few decades. In this paper, we propose an alternative, novel, general, and effective approach using enforcement of hyperproperties– a powerful formalism for expressing and reasoning about a wide range of information-flow security policies. We study black- vs. gray- vs. white-box enforcement of hyperproperties expressed by nondeterministic finite-word hyperautomata (NFH), where the enforcer has null, some, or complete information about the implementation of the system under scrutiny. Given an NFH, in order to generate a runtime enforcer, we reduce the problem to controller synthesis for hyperproperties and subsequently to the satisfiability problem for quantified Boolean formulas (QBFs). The resulting enforcers are transferable with low-overhead. We conduct a rich set of case studies, including information-flow control for JavaScript code, as well as synthesizing obfuscators for control plants.","lang":"eng"}],"article_processing_charge":"Yes (via OA deal)","title":"Gray-box runtime enforcement of hyperproperties","article_number":"30","date_created":"2025-08-17T22:01:36Z","year":"2025","publication":"Acta Informatica","doi":"10.1007/s00236-025-00502-1","publication_identifier":{"eissn":["1432-0525"],"issn":["0001-5903"]},"issue":"3","file":[{"creator":"dernst","success":1,"date_created":"2025-09-02T05:53:47Z","file_name":"2025_ActaInformatica_Hsu.pdf","content_type":"application/pdf","checksum":"90a43350fd4a8c5cb5b1b0e1aea7970d","relation":"main_file","access_level":"open_access","file_size":6505049,"date_updated":"2025-09-02T05:53:47Z","file_id":"20267"}],"quality_controlled":"1","corr_author":"1","ddc":["000"],"has_accepted_license":"1","acknowledgement":"This project was funded in part by the Austrian Science Fund (FWF) SFB project SpyCoDe F8502, Vienna Science and Technology Fund (WWTF) [10.47379/ICT19018] (ProbInG) and WWTF project ICT22-023 (TAIGER), National Science Foundation (NSF) CPS Award 1837680, NSF award ECCS-2144416 and NSF SaTC Award 2245114. Open access funding provided by Institute of Science and Technology (IST Austria).","type":"journal_article","intvolume":"        62","oa_version":"Published Version","article_type":"original","scopus_import":"1","_id":"20186","file_date_updated":"2025-09-02T05:53:47Z","oa":1,"isi":1,"date_updated":"2025-09-30T14:20:11Z","publisher":"Springer Nature","department":[{"_id":"ToHe"}],"date_published":"2025-09-01T00:00:00Z","language":[{"iso":"eng"}],"month":"09","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"OA_type":"hybrid","status":"public","day":"01","project":[{"name":"Interface Theory for Security and Privacy","_id":"34a1b658-11ca-11ed-8bc3-c75229f0241e","grant_number":"F8502"}],"citation":{"ieee":"T. H. Hsu, A. A. Oliveira da Costa, A. Wintenberg, E. Bartocci, and B. Bonakdarpour, “Gray-box runtime enforcement of hyperproperties,” <i>Acta Informatica</i>, vol. 62, no. 3. Springer Nature, 2025.","short":"T.H. Hsu, A.A. Oliveira da Costa, A. Wintenberg, E. Bartocci, B. Bonakdarpour, Acta Informatica 62 (2025).","ama":"Hsu TH, Oliveira da Costa AA, Wintenberg A, Bartocci E, Bonakdarpour B. Gray-box runtime enforcement of hyperproperties. <i>Acta Informatica</i>. 2025;62(3). doi:<a href=\"https://doi.org/10.1007/s00236-025-00502-1\">10.1007/s00236-025-00502-1</a>","ista":"Hsu TH, Oliveira da Costa AA, Wintenberg A, Bartocci E, Bonakdarpour B. 2025. Gray-box runtime enforcement of hyperproperties. Acta Informatica. 62(3), 30.","apa":"Hsu, T. H., Oliveira da Costa, A. A., Wintenberg, A., Bartocci, E., &#38; Bonakdarpour, B. (2025). Gray-box runtime enforcement of hyperproperties. <i>Acta Informatica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00236-025-00502-1\">https://doi.org/10.1007/s00236-025-00502-1</a>","chicago":"Hsu, Tzu Han, Ana A Oliveira da Costa, Andrew Wintenberg, Ezio Bartocci, and Borzoo Bonakdarpour. “Gray-Box Runtime Enforcement of Hyperproperties.” <i>Acta Informatica</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s00236-025-00502-1\">https://doi.org/10.1007/s00236-025-00502-1</a>.","mla":"Hsu, Tzu Han, et al. “Gray-Box Runtime Enforcement of Hyperproperties.” <i>Acta Informatica</i>, vol. 62, no. 3, 30, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1007/s00236-025-00502-1\">10.1007/s00236-025-00502-1</a>."},"PlanS_conform":"1"},{"publication":"Plant Journal","issue":"3","doi":"10.1111/tpj.70396","publication_identifier":{"issn":["0960-7412"],"eissn":["1365-313X"]},"article_number":"e70396","year":"2025","date_created":"2025-08-17T22:01:36Z","ddc":["580"],"has_accepted_license":"1","quality_controlled":"1","file":[{"file_id":"20264","access_level":"open_access","relation":"main_file","checksum":"1cdc3341d2d23101abca72521f1f23cb","file_size":5791111,"date_updated":"2025-09-01T14:09:31Z","date_created":"2025-09-01T14:09:31Z","content_type":"application/pdf","file_name":"2025_PlantJournal_Babic.pdf","success":1,"creator":"dernst"}],"corr_author":"1","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"20362"}]},"pmid":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"OA_place":"publisher","volume":123,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","author":[{"full_name":"Babic, David","id":"db566d23-f6e0-11ea-865d-e6f270e968e7","last_name":"Babic","first_name":"David"},{"last_name":"Abualia","first_name":"Rashed","full_name":"Abualia, Rashed","orcid":"0000-0002-9357-9415","id":"4827E134-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Fiedler","first_name":"Lukas","id":"7c417475-8972-11ed-ae7b-8b674ca26986","full_name":"Fiedler, Lukas"},{"orcid":"0000-0001-5187-8401","id":"44B04502-A9ED-11E9-B6FC-583AE6697425","full_name":"Qi, Linlin","first_name":"Linlin","last_name":"Qi"},{"full_name":"Tellier, Frédérique","first_name":"Frédérique","last_name":"Tellier"},{"first_name":"Adrijana","last_name":"Smoljan","full_name":"Smoljan, Adrijana","id":"cced8a85-223e-11ed-af04-b0596c55053b"},{"first_name":"Hana","last_name":"Rakusova","full_name":"Rakusova, Hana","id":"4CAAA450-78D2-11EA-8E57-B40A396E08BA"},{"last_name":"Valošek","first_name":"Petr","full_name":"Valošek, Petr","id":"3CDB6F94-F248-11E8-B48F-1D18A9856A87"},{"id":"31435098-F248-11E8-B48F-1D18A9856A87","full_name":"Han, Huibin","last_name":"Han","first_name":"Huibin"},{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","full_name":"Benková, Eva","first_name":"Eva","last_name":"Benková"},{"last_name":"Faure","first_name":"Jean Denis","full_name":"Faure, Jean Denis"},{"full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jiří"}],"title":"Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development","abstract":[{"text":"Very long-chain fatty acids (VLCFAs), being constituents of different types of lipids, are critical factors in plant development, presumably due to their impact on the endomembrane system. The VLCFAs are synthesized in the endoplasmic reticulum by a heterotetrameric enzymatic complex including β-ketoacyl CoA reductase 1 (KCR1), whose mutant is lethal. Here, we describe the ectopic shoot meristems (esm) mutant, a viable kcr1 allele presumably affecting surface properties of the KCR1 protein. This kcr1-2 mutant shows reduced fatty acyl elongation that impacts VLCFAs. The kcr1-2 plants show severe defects during different stages of development, which all correlate with defects in polar localization and subcellular trafficking of PIN auxin transporters and resulting asymmetric auxin distribution. Detailed analysis of KCR1 expression and patterning defects in kcr1-2 suggests that KCR1 plays a role in delineating boundaries around meristematic and specialized differentiating tissues, including root and shoot meristems, initiating lateral roots, lateral root primordia, and trichomes. In these contexts, KCR1-produced VLCFAs may act in a non-cell-autonomous manner. Viable kcr1-2 represents a useful tool to study VLCFA roles in plant development and highlights VLCFAs as critical developmental factors at the interface of cell polarity and tissue development.","lang":"eng"}],"external_id":{"pmid":["40782342"],"isi":["001547884300001"]},"publication_status":"published","article_processing_charge":"Yes (via OA deal)","day":"01","status":"public","OA_type":"hybrid","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"project":[{"name":"Peptide receptors for auxin canalization in Arabidopsis","grant_number":"I06123","_id":"bd76d395-d553-11ed-ba76-f678c14f9033"}],"PlanS_conform":"1","citation":{"mla":"Babic, David, et al. “Biosynthesis of Very Long-Chain Fatty Acids Is Required for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic Development.” <i>Plant Journal</i>, vol. 123, no. 3, e70396, Wiley, 2025, doi:<a href=\"https://doi.org/10.1111/tpj.70396\">10.1111/tpj.70396</a>.","chicago":"Babic, David, Rashed Abualia, Lukas Fiedler, Linlin Qi, Frédérique Tellier, Adrijana Smoljan, Hana Rakusova, et al. “Biosynthesis of Very Long-Chain Fatty Acids Is Required for Arabidopsis Auxin-Mediated Embryonic and Post-Embryonic Development.” <i>Plant Journal</i>. Wiley, 2025. <a href=\"https://doi.org/10.1111/tpj.70396\">https://doi.org/10.1111/tpj.70396</a>.","apa":"Babic, D., Abualia, R., Fiedler, L., Qi, L., Tellier, F., Smoljan, A., … Friml, J. (2025). Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. <i>Plant Journal</i>. Wiley. <a href=\"https://doi.org/10.1111/tpj.70396\">https://doi.org/10.1111/tpj.70396</a>","ista":"Babic D, Abualia R, Fiedler L, Qi L, Tellier F, Smoljan A, Rakusova H, Valošek P, Han H, Benková E, Faure JD, Friml J. 2025. Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. Plant Journal. 123(3), e70396.","ama":"Babic D, Abualia R, Fiedler L, et al. Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development. <i>Plant Journal</i>. 2025;123(3). doi:<a href=\"https://doi.org/10.1111/tpj.70396\">10.1111/tpj.70396</a>","ieee":"D. Babic <i>et al.</i>, “Biosynthesis of very long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development,” <i>Plant Journal</i>, vol. 123, no. 3. Wiley, 2025.","short":"D. Babic, R. Abualia, L. Fiedler, L. Qi, F. Tellier, A. Smoljan, H. Rakusova, P. Valošek, H. Han, E. Benková, J.D. Faure, J. Friml, Plant Journal 123 (2025)."},"_id":"20187","scopus_import":"1","type":"journal_article","acknowledgement":"We gratefully acknowledge the Imaging and Optics, Electron Microscopy (especially Vanessa Zheden for technical assistance) and Life Science (in particular Dorota Jaworska) facilities at ISTA for their continuous support. Authors would like to thank Michelle Gallei for advice during the generation of the transgenic lines; Zuzana Gelová for advice with DR5rev::GFP analyses; Ivan Kulich for help and advice on trichome imaging; Aline Monzer for generous help with hypocotyl and root analyses; Shutang Tan for help with the NGS data analysis; and Milan Župunski for advice on abiotic stress experiments. We would like to thank Dolf Weijers for the SOSEKI (SOK) marker line seeds. This work has benefited from the support of IJPB's Plant Observatory platforms P0-Chem.\r\n\r\nThis work was supported by Austrian Science Fund (FWF) (I 6123-B) and Science and Technology Department of Jiangxi Province (20223BCJ25037) to Huibin Han. The IJPB benefits from the support of Saclay Plant Sciences-SPS (ANR-17-EUR-0007).","article_type":"original","intvolume":"       123","oa_version":"Published Version","publisher":"Wiley","department":[{"_id":"EvBe"},{"_id":"JiFr"},{"_id":"GradSch"}],"date_updated":"2026-04-07T11:52:02Z","language":[{"iso":"eng"}],"month":"08","date_published":"2025-08-01T00:00:00Z","oa":1,"file_date_updated":"2025-09-01T14:09:31Z","isi":1},{"date_created":"2025-08-17T22:01:36Z","year":"2025","article_number":"263779","publication_identifier":{"issn":[" 0021-9533"],"eissn":["1477-9137"]},"doi":"10.1242/jcs.263779","issue":"15","publication":"Journal of Cell Science","quality_controlled":"1","file":[{"success":1,"creator":"dernst","date_created":"2025-09-01T10:02:24Z","content_type":"application/pdf","file_name":"2025_JourCellScience_Jikko.pdf","access_level":"open_access","checksum":"29f42619dab5ce251a20c769ed4581c0","relation":"main_file","file_size":12393297,"date_updated":"2025-09-01T10:02:24Z","file_id":"20262"}],"has_accepted_license":"1","ddc":["570"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Jikko","first_name":"Yuya","full_name":"Jikko, Yuya"},{"last_name":"Deguchi","first_name":"Eriko","full_name":"Deguchi, Eriko"},{"full_name":"Matsuda, Kimiya","last_name":"Matsuda","first_name":"Kimiya"},{"full_name":"Hino, Naoya","id":"5299a9ce-7679-11eb-a7bc-d1e62b936307","first_name":"Naoya","last_name":"Hino"},{"full_name":"Tsukiji, Shinya","last_name":"Tsukiji","first_name":"Shinya"},{"full_name":"Matsuda, Michiyuki","last_name":"Matsuda","first_name":"Michiyuki"},{"full_name":"Terai, Kenta","last_name":"Terai","first_name":"Kenta"}],"OA_place":"publisher","volume":138,"pmid":1,"article_processing_charge":"Yes (via OA deal)","external_id":{"isi":["001567723900009"],"pmid":["40667649"]},"publication_status":"published","abstract":[{"text":"Collective cell migration is coordinated by the front-to-rear intercellular propagation of EGFR-Ras-ERK pathway activation. However, the molecular mechanisms integrating front-to-rear information into this intercellular signaling cascade, particularly the determinants of cellular front-side specification, remain elusive. We visualized the activity of EGFR, Ras, Rac1 and Rab5A (hereafter Rab5) by using FRET biosensors and chemogenetic tools. Whereas EGFR activation was uniformly observed within cells, Ras activation was biased to the front side within cells. The polarized Ras activation depended on Merlin and Rac1, which also showed front-biased activation. Furthermore, Rab5, a crucial regulator of cell migration, demonstrated similar front-biased activation and was found to function downstream of Ras while being necessary for Rac1 activation. Thus, the positive feedback loop consisting of Ras, Rab5 and Rac1 is activated primarily at the front of collectively migrating cells. These findings offer new spatio-temporal insight into processing front–rear information during collective cell migration.","lang":"eng"}],"title":"Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"OA_type":"hybrid","day":"01","status":"public","citation":{"chicago":"Jikko, Yuya, Eriko Deguchi, Kimiya Matsuda, Naoya Hino, Shinya Tsukiji, Michiyuki Matsuda, and Kenta Terai. “Front-Biased Activation of the Ras-Rab5-Rac1 Loop Coordinates Collective Cell Migration.” <i>Journal of Cell Science</i>. The Company of Biologists, 2025. <a href=\"https://doi.org/10.1242/jcs.263779\">https://doi.org/10.1242/jcs.263779</a>.","apa":"Jikko, Y., Deguchi, E., Matsuda, K., Hino, N., Tsukiji, S., Matsuda, M., &#38; Terai, K. (2025). Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. <i>Journal of Cell Science</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/jcs.263779\">https://doi.org/10.1242/jcs.263779</a>","mla":"Jikko, Yuya, et al. “Front-Biased Activation of the Ras-Rab5-Rac1 Loop Coordinates Collective Cell Migration.” <i>Journal of Cell Science</i>, vol. 138, no. 15, 263779, The Company of Biologists, 2025, doi:<a href=\"https://doi.org/10.1242/jcs.263779\">10.1242/jcs.263779</a>.","short":"Y. Jikko, E. Deguchi, K. Matsuda, N. Hino, S. Tsukiji, M. Matsuda, K. Terai, Journal of Cell Science 138 (2025).","ieee":"Y. Jikko <i>et al.</i>, “Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration,” <i>Journal of Cell Science</i>, vol. 138, no. 15. The Company of Biologists, 2025.","ista":"Jikko Y, Deguchi E, Matsuda K, Hino N, Tsukiji S, Matsuda M, Terai K. 2025. Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. Journal of Cell Science. 138(15), 263779.","ama":"Jikko Y, Deguchi E, Matsuda K, et al. Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. <i>Journal of Cell Science</i>. 2025;138(15). doi:<a href=\"https://doi.org/10.1242/jcs.263779\">10.1242/jcs.263779</a>"},"PlanS_conform":"1","intvolume":"       138","oa_version":"Published Version","article_type":"original","acknowledgement":"We are grateful to the members of the Matsuda Laboratory for their helpful input, to K. Hirano, T. Uesugi and K. Takakura, who provided technical assistance, and to the Medical Research Support Center of Kyoto University for DNA sequence analysis. This work was supported by the Kyoto University Live Imaging Center. Financial support was provided by Japan Society for the Promotion of Science (JSPS) KAKENHI grants (21H05226 to K.T., 19H00993 and 20H05898 to M.M.), a Japan Science and Technology Agency (JST) CREST grant (JPMJCR1654 to M.M.), and a JST Moonshot Research and Development Program grant (JPMJPS2022 to M.M.). Open Access funding provided by Tokushima University. Deposited in PMC for immediate release.","type":"journal_article","scopus_import":"1","_id":"20188","isi":1,"file_date_updated":"2025-09-01T10:02:24Z","oa":1,"date_published":"2025-08-01T00:00:00Z","language":[{"iso":"eng"}],"month":"08","date_updated":"2025-11-27T14:12:24Z","department":[{"_id":"CaHe"}],"publisher":"The Company of Biologists"},{"project":[{"call_identifier":"H2020","name":"Vigilant Algorithmic Monitoring of Software","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","grant_number":"101020093"}],"citation":{"mla":"Froleyks, Nils, et al. “Introducing Certificates to the Hardware Model Checking Competition.” <i>37th International Conference on Computer Aided Verification</i>, vol. 15931, Springer Nature, 2025, pp. 281–95, doi:<a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">10.1007/978-3-031-98668-0_14</a>.","chicago":"Froleyks, Nils, Emily Yu, Mathias Preiner, Armin Biere, and Keijo Heljanko. “Introducing Certificates to the Hardware Model Checking Competition.” In <i>37th International Conference on Computer Aided Verification</i>, 15931:281–95. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">https://doi.org/10.1007/978-3-031-98668-0_14</a>.","apa":"Froleyks, N., Yu, E., Preiner, M., Biere, A., &#38; Heljanko, K. (2025). Introducing certificates to the hardware model checking competition. In <i>37th International Conference on Computer Aided Verification</i> (Vol. 15931, pp. 281–295). Zagreb, Croatia: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">https://doi.org/10.1007/978-3-031-98668-0_14</a>","ista":"Froleyks N, Yu E, Preiner M, Biere A, Heljanko K. 2025. Introducing certificates to the hardware model checking competition. 37th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 15931, 281–295.","ama":"Froleyks N, Yu E, Preiner M, Biere A, Heljanko K. Introducing certificates to the hardware model checking competition. In: <i>37th International Conference on Computer Aided Verification</i>. Vol 15931. Springer Nature; 2025:281-295. doi:<a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">10.1007/978-3-031-98668-0_14</a>","short":"N. Froleyks, E. Yu, M. Preiner, A. Biere, K. Heljanko, in:, 37th International Conference on Computer Aided Verification, Springer Nature, 2025, pp. 281–295.","ieee":"N. Froleyks, E. Yu, M. Preiner, A. Biere, and K. Heljanko, “Introducing certificates to the hardware model checking competition,” in <i>37th International Conference on Computer Aided Verification</i>, Zagreb, Croatia, 2025, vol. 15931, pp. 281–295."},"day":"01","status":"public","alternative_title":["LNCS"],"ec_funded":1,"OA_type":"hybrid","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"ToHe"}],"publisher":"Springer Nature","date_updated":"2025-12-01T12:34:05Z","language":[{"iso":"eng"}],"month":"01","date_published":"2025-01-01T00:00:00Z","oa":1,"file_date_updated":"2025-09-02T05:46:10Z","isi":1,"_id":"20189","scopus_import":"1","type":"conference","acknowledgement":"This work is supported in part by the ERC-2020-AdG 101020093, the LIT AI Lab funded by the State of Upper Austria, the Research Council of Finland under the project 336092, and a gift from Intel Corporation.\r\nFurthermore we of course also owe a big thank-you to the submitters of model checkers and benchmarks to the competition over all these years. Without their enthusiasm and support neither the competition nor this study would exist.","oa_version":"Published Version","intvolume":"     15931","conference":{"end_date":"2025-07-25","location":"Zagreb, Croatia","name":"CAV: Computer Aided Verification","start_date":"2025-07-23"},"ddc":["000"],"has_accepted_license":"1","file":[{"creator":"dernst","success":1,"date_created":"2025-09-02T05:46:10Z","content_type":"application/pdf","file_name":"2025_CAV_Froleyks.pdf","relation":"main_file","checksum":"15ec1bc9b9409d3b2736f4c9d5f42fd1","access_level":"open_access","file_size":1078274,"date_updated":"2025-09-02T05:46:10Z","file_id":"20266"}],"quality_controlled":"1","publication":"37th International Conference on Computer Aided Verification","publication_identifier":{"issn":["0302-9743"],"isbn":["9783031986673"],"eissn":["1611-3349"]},"doi":"10.1007/978-3-031-98668-0_14","year":"2025","date_created":"2025-08-17T22:01:36Z","title":"Introducing certificates to the hardware model checking competition","abstract":[{"text":"Certification was made mandatory for the first time in the latest hardware model checking competition. In this case study, we investigate the trade-offs of requiring certificates for both passing and failing properties in the competition. Our evaluation shows that participating model checkers were able to produce compact, correct certificates that could be verified with minimal overhead. Furthermore, the certifying winner of the competition outperforms the previous non-certifying state-of-the-art model checker, demonstrating that certification can be adopted without compromising model checking efficiency.","lang":"eng"}],"publication_status":"published","external_id":{"isi":["001562507100014"]},"page":"281-295","article_processing_charge":"Yes (in subscription journal)","OA_place":"publisher","volume":15931,"author":[{"last_name":"Froleyks","first_name":"Nils","full_name":"Froleyks, Nils"},{"last_name":"Yu","first_name":"Zhengqi","full_name":"Yu, Zhengqi","id":"20aa2ae8-f2f1-11ed-bbfa-8205053f1342","orcid":"0000-0002-4993-773X"},{"full_name":"Preiner, Mathias","last_name":"Preiner","first_name":"Mathias"},{"first_name":"Armin","last_name":"Biere","full_name":"Biere, Armin"},{"full_name":"Heljanko, Keijo","first_name":"Keijo","last_name":"Heljanko"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"title":"21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations","article_processing_charge":"No","abstract":[{"lang":"eng","text":"We study the physical origin and spectroscopic impact of extreme nebular emission in high-redshift galaxies. The nebular continuum, which can appear during an extreme starburst, is of particular importance as it tends to redden UV slopes and has a significant contribution to the UV luminosities of galaxies. Furthermore, its shape can be used to infer the gas density and temperature of the interstellar medium. First, we provide a theoretical background, showing how different stellar populations (SPS models, initial mass functions (IMFs), and stellar temperatures) and nebular conditions impact observed galaxy spectra. We demonstrate that, for systems with strong nebular continuum emission, 1) UV fluxes can increase by up to 0.7~mag (or more in the case of hot/massive stars) above the stellar continuum, which may help reconcile the surprising abundance of bright high-redshift galaxies and the elevated UV luminosity density at z>10, 2) at high gas densities, UV slopes can redden from \\beta<-2.5 to \\beta\\sim-1, 3) observational measurements of \\xi_{\\rm ion} are gross underestimates, and 4) UV downturns from two-photon emission can masquerade as damped Ly\\alpha systems. Second, we present a dataset of 58 galaxies observed with NIRSpec on JWST at 2.5<z<9.0 that are selected to have strong nebular continuum emission via the detection of the Balmer jump. Five of the 58 spectra are consistent with being dominated by nebular emission, exhibiting both a Balmer jump and a UV downturn consistent with two-photon emission. For some galaxies, this may imply the presence of hot massive stars and a top-heavy IMF. We conclude by exploring the properties of spectroscopically confirmed z>10 galaxies, finding that UV slopes and UV downturns are in some cases redder or steeper than expected from SPS models, which may hint at more exotic (e.g. hotter/more massive stars or AGN) ionizing sources."}],"external_id":{"arxiv":["2408.03189"]},"publication_status":"published","author":[{"full_name":"Katz, Harley","first_name":"Harley","last_name":"Katz"},{"first_name":"Alex J.","last_name":"Cameron","full_name":"Cameron, Alex J."},{"last_name":"Saxena","first_name":"Aayush","full_name":"Saxena, Aayush"},{"last_name":"Barrufet","first_name":"Laia","full_name":"Barrufet, Laia"},{"full_name":"Choustikov, Nicholas","first_name":"Nicholas","last_name":"Choustikov"},{"full_name":"Cleri, Nikko J.","last_name":"Cleri","first_name":"Nikko J."},{"last_name":"De Graaff","first_name":"Anna","full_name":"De Graaff, Anna"},{"full_name":"Ellis, Richard S.","last_name":"Ellis","first_name":"Richard S."},{"first_name":"Robert A.E.","last_name":"Fosbury","full_name":"Fosbury, Robert A.E."},{"first_name":"Kasper E.","last_name":"Heintz","full_name":"Heintz, Kasper E."},{"full_name":"Maseda, Michael","first_name":"Michael","last_name":"Maseda"},{"orcid":"0000-0003-2871-127X","id":"7439a258-f3c0-11ec-9501-9df22fe06720","full_name":"Matthee, Jorryt J","first_name":"Jorryt J","last_name":"Matthee"},{"first_name":"Ian","last_name":"Mcconachie","full_name":"Mcconachie, Ian"},{"first_name":"Pascal A.","last_name":"Oesch","full_name":"Oesch, Pascal A."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":8,"OA_place":"publisher","has_accepted_license":"1","ddc":["520"],"file":[{"relation":"main_file","checksum":"ba469d132907147f9e86d87f9124dd14","access_level":"open_access","date_updated":"2025-09-30T14:28:25Z","file_size":1836432,"file_id":"20412","creator":"dernst","success":1,"date_created":"2025-09-30T14:28:25Z","content_type":"application/pdf","file_name":"2025_OpenJourAstrophysics_Katz.pdf"}],"quality_controlled":"1","doi":"10.33232/001c.142570","publication_identifier":{"eissn":["2565-6120"]},"publication":"The Open Journal of Astrophysics","year":"2025","date_created":"2025-08-17T22:01:37Z","language":[{"iso":"eng"}],"month":"07","date_published":"2025-07-25T00:00:00Z","department":[{"_id":"JoMa"}],"publisher":"Maynooth Academic Publishing","arxiv":1,"date_updated":"2025-09-30T14:29:33Z","oa":1,"file_date_updated":"2025-09-30T14:28:25Z","_id":"20192","scopus_import":"1","article_type":"original","intvolume":"         8","oa_version":"Published Version","acknowledgement":"HK thanks Andrey Kravtsov for insightful comments and thoughtful discussions. We sincerely thank the PIs and Co-Is of the JWST programs where spectral data was made publicly available on the DJA. We refer interested readers to the following papers for survey descriptions regarding the spectral data: Bunker et al. (2023a); D’Eugenio et al. (2024); Bezanson et al. (2022); Barrufet et al. (2024); de Graaff et al. (2024); Finkelstein et al. (2024); Glazebrook et al. (2024); Pierel et al. (2024); Siebert et al. (2024); Maseda et al. (2024). This work is based in part on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs listed in Table 1. AJC and AS acknowledge funding from the “FirstGalaxies” Advanced Grant from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 789056). ","type":"journal_article","PlanS_conform":"1","citation":{"mla":"Katz, Harley, et al. “21 Balmer Jump Street: The Nebular Continuum at High Redshift and Implications for the Bright Galaxy Problem, UV Continuum Slopes, and Early Stellar Populations.” <i>The Open Journal of Astrophysics</i>, vol. 8, Maynooth Academic Publishing, 2025, doi:<a href=\"https://doi.org/10.33232/001c.142570\">10.33232/001c.142570</a>.","apa":"Katz, H., Cameron, A. J., Saxena, A., Barrufet, L., Choustikov, N., Cleri, N. J., … Oesch, P. A. (2025). 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. <i>The Open Journal of Astrophysics</i>. Maynooth Academic Publishing. <a href=\"https://doi.org/10.33232/001c.142570\">https://doi.org/10.33232/001c.142570</a>","chicago":"Katz, Harley, Alex J. Cameron, Aayush Saxena, Laia Barrufet, Nicholas Choustikov, Nikko J. Cleri, Anna De Graaff, et al. “21 Balmer Jump Street: The Nebular Continuum at High Redshift and Implications for the Bright Galaxy Problem, UV Continuum Slopes, and Early Stellar Populations.” <i>The Open Journal of Astrophysics</i>. Maynooth Academic Publishing, 2025. <a href=\"https://doi.org/10.33232/001c.142570\">https://doi.org/10.33232/001c.142570</a>.","ama":"Katz H, Cameron AJ, Saxena A, et al. 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. <i>The Open Journal of Astrophysics</i>. 2025;8. doi:<a href=\"https://doi.org/10.33232/001c.142570\">10.33232/001c.142570</a>","ista":"Katz H, Cameron AJ, Saxena A, Barrufet L, Choustikov N, Cleri NJ, De Graaff A, Ellis RS, Fosbury RAE, Heintz KE, Maseda M, Matthee JJ, Mcconachie I, Oesch PA. 2025. 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. The Open Journal of Astrophysics. 8.","ieee":"H. Katz <i>et al.</i>, “21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations,” <i>The Open Journal of Astrophysics</i>, vol. 8. Maynooth Academic Publishing, 2025.","short":"H. Katz, A.J. Cameron, A. Saxena, L. Barrufet, N. Choustikov, N.J. Cleri, A. De Graaff, R.S. Ellis, R.A.E. Fosbury, K.E. Heintz, M. Maseda, J.J. Matthee, I. Mcconachie, P.A. Oesch, The Open Journal of Astrophysics 8 (2025)."},"status":"public","day":"25","OA_type":"diamond","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"}},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Masafusa","last_name":"Onoue","full_name":"Onoue, Masafusa"},{"last_name":"Ding","first_name":"Xuheng","full_name":"Ding, Xuheng"},{"full_name":"Silverman, John D.","last_name":"Silverman","first_name":"John D."},{"last_name":"Matsuoka","first_name":"Yoshiki","full_name":"Matsuoka, Yoshiki"},{"last_name":"Izumi","first_name":"Takuma","full_name":"Izumi, Takuma"},{"full_name":"Strauss, Michael A.","last_name":"Strauss","first_name":"Michael A."},{"full_name":"Ward, Charlotte","first_name":"Charlotte","last_name":"Ward"},{"last_name":"Phillips","first_name":"Camryn L.","full_name":"Phillips, Camryn L."},{"last_name":"Ito","first_name":"Kei","full_name":"Ito, Kei"},{"last_name":"Andika","first_name":"Irham T.","full_name":"Andika, Irham T."},{"first_name":"Kentaro","last_name":"Aoki","full_name":"Aoki, Kentaro"},{"last_name":"Arita","first_name":"Junya","full_name":"Arita, Junya"},{"full_name":"Baba, Shunsuke","last_name":"Baba","first_name":"Shunsuke"},{"first_name":"Rebekka","last_name":"Bieri","full_name":"Bieri, Rebekka"},{"full_name":"Bosman, Sarah E.I.","first_name":"Sarah E.I.","last_name":"Bosman"},{"last_name":"Eilers","first_name":"Anna Christina","full_name":"Eilers, Anna Christina"},{"full_name":"Fujimoto, Seiji","last_name":"Fujimoto","first_name":"Seiji"},{"full_name":"Habouzit, Melanie","last_name":"Habouzit","first_name":"Melanie"},{"full_name":"Haiman, Zoltán","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","orcid":"0000-0003-3633-5403","first_name":"Zoltán","last_name":"Haiman"},{"full_name":"Imanishi, Masatoshi","last_name":"Imanishi","first_name":"Masatoshi"},{"full_name":"Inayoshi, Kohei","first_name":"Kohei","last_name":"Inayoshi"},{"full_name":"Iwasawa, Kazushi","first_name":"Kazushi","last_name":"Iwasawa"},{"full_name":"Jahnke, Knud","first_name":"Knud","last_name":"Jahnke"},{"full_name":"Kashikawa, Nobunari","first_name":"Nobunari","last_name":"Kashikawa"},{"first_name":"Toshihiro","last_name":"Kawaguchi","full_name":"Kawaguchi, Toshihiro"},{"full_name":"Kohno, Kotaro","first_name":"Kotaro","last_name":"Kohno"},{"first_name":"Chien Hsiu","last_name":"Lee","full_name":"Lee, Chien Hsiu"},{"first_name":"Junyao","last_name":"Li","full_name":"Li, Junyao"},{"full_name":"Lupi, Alessandro","last_name":"Lupi","first_name":"Alessandro"},{"first_name":"Jianwei","last_name":"Lyu","full_name":"Lyu, Jianwei"},{"full_name":"Nagao, Tohru","last_name":"Nagao","first_name":"Tohru"},{"full_name":"Overzier, Roderik","last_name":"Overzier","first_name":"Roderik"},{"full_name":"Schindler, Jan Torge","first_name":"Jan Torge","last_name":"Schindler"},{"full_name":"Schramm, Malte","last_name":"Schramm","first_name":"Malte"},{"last_name":"Scoggins","first_name":"Matthew T.","full_name":"Scoggins, Matthew T."},{"full_name":"Shimasaku, Kazuhiro","last_name":"Shimasaku","first_name":"Kazuhiro"},{"first_name":"Yoshiki","last_name":"Toba","full_name":"Toba, Yoshiki"},{"full_name":"Trakhtenbrot, Benny","first_name":"Benny","last_name":"Trakhtenbrot"},{"last_name":"Trebitsch","first_name":"Maxime","full_name":"Trebitsch, Maxime"},{"full_name":"Treu, Tommaso","first_name":"Tommaso","last_name":"Treu"},{"full_name":"Umehata, Hideki","first_name":"Hideki","last_name":"Umehata"},{"first_name":"Bram","last_name":"Venemans","full_name":"Venemans, Bram"},{"last_name":"Vestergaard","first_name":"Marianne","full_name":"Vestergaard, Marianne"},{"first_name":"Marta","last_name":"Volonteri","full_name":"Volonteri, Marta"},{"full_name":"Walter, Fabian","first_name":"Fabian","last_name":"Walter"},{"last_name":"Wang","first_name":"Feige","full_name":"Wang, Feige"},{"first_name":"Jinyi","last_name":"Yang","full_name":"Yang, Jinyi"},{"last_name":"Zhang","first_name":"Haowen","full_name":"Zhang, Haowen"}],"volume":9,"OA_place":"repository","title":"A post-starburst pathway for the formation of massive galaxies and black holes at z > 6","article_processing_charge":"No","page":"1541-1552","external_id":{"isi":["001548138600001"],"arxiv":["2409.07113"]},"publication_status":"published","abstract":[{"lang":"eng","text":"Understanding the rapid formation of supermassive black holes in the early Universe requires insights into stellar mass growth in host galaxies. Here we present NIRSpec rest-frame optical spectra and NIRCam imaging from JWST of two galaxies at z > 6, both hosting moderate-luminosity quasars. These galaxies exhibit Balmer absorption lines, like low-redshift post-starburst galaxies. Our analyses of the medium-resolution spectra and multiband photometry show that the bulk of the stellar mass (log(M*/M☉) ≥ 10.6) formed in starburst episodes at redshift 9 and 7. One of the galaxies shows a clear Balmer break and lacks spatially resolved Hα emission. It falls well below the star-formation main sequence at z = 6, indicating quiescence. The other is transitioning to quiescence; together, these massive galaxies are among the most distant post-starburst systems known. The blueshifted wings of the quasar [O iii] emission lines indicate quasar-driven outflow, which possibly influences star formation. Direct stellar velocity dispersion measurements reveal that one galaxy follows the local black hole mass versus σ* relation whereas the other is overmassive. The existence of massive post-starburst galaxies hosting billion-solar-mass black holes in short-lived quasar phases indicates that supermassive black holes and host galaxies played a principal role in each other’s rapid early formation."}],"doi":"10.1038/s41550-025-02628-1","publication_identifier":{"eissn":["2397-3366"]},"publication":"Nature Astronomy","date_created":"2025-08-17T22:01:38Z","year":"2025","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2409.07113"}],"quality_controlled":"1","scopus_import":"1","_id":"20193","oa_version":"Preprint","intvolume":"         9","article_type":"original","acknowledgement":"We thank A. C. Carnall for supporting our use of Bagpipes. We thank Y. Fu for his help on the use of QSOFitMORE. We thank J. Greene, S. Toft, T. Kakimoto and M. Tanaka for fruitful discussions. This work is based on observations made with the NASA/ESA/CSA JWST. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, under NASA contract NAS 5-03127 for JWST. These observations are associated with programmes GO 1967 and GO 3859. Support for these programmes was provided by NASA through a grant from the Space Telescope Science Institute. This work was supported by World Premier International Research Center Initiative, MEXT, Japan. This work used computing resources at Kavli IPMU. M.O., X.D., J.D.S., Y.M., T.I., K. Ito, K.K. and H.U. are supported by the Japan Society for the Promotion of Science (KAKENHI Grant Numbers JP24K22894, JP22K14071, JP18H01251, JP22H01262, JP21H04494, JP20K14531, JP23K13141, JP17H06130 and JP20H01953). M.O. and K. Inayoshi acknowledge support from the National Natural Science Foundation of China (Grant Numbers 12150410307, 12073003, 11721303, 11991052 and 11950410493). K. Inayoshi acknowledges support from the China Manned Space Project (Grant Numbers CMS-CSST-2021-A04 and CMS-CSST-2021-A06). S.E.I.B. is funded by the Deutsche Forschungsgemeinschaft (German Research Foundation) under Emmy Noether Grant Number BO 5771/1-1. Z.H., T.T. and M.S. acknowledge support from the NSF (Grant Numbers AST-2006176, AST-1907208 and AST-2006177). A.L. acknowledges funding from MUR (Grant Number PRIN 2022935STW). B.T. acknowledges support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement Number 950533) and from the Israel Science Foundation (Grant Number 1849/19). F. Walter acknowledges support from the ERC (Grant Cosmic_gas). J.-T.S. is supported by the Deutsche Forschungsgemeinschaft (Project Number 518006966). M.T. acknowledges support from the NWO (Grant Number 0.16.VIDI.189.162, ODIN). S.F. acknowledges support from NASA through the NASA Hubble Fellowship (Grant Number HST-HF2-51505.001-A awarded by the Space Telescope Science Institute). K. Iwasawa acknowledges support under Grant Number PID2022-136827NB-C44 funded by MCIN/AEI/10.13039/501100011033 /FEDER, EU. M. Vestergaard gratefully acknowledges financial support from the Independent Research Fund Denmark (Grant Numbers DFF 8021-00130 and 3103-00146). F. Wang acknowledges support from the NSF (Award Number AST-2513040). R.B. is supported by the SNSF through the Ambizione Grant PZ00P2_223532.","type":"journal_article","date_published":"2025-10-01T00:00:00Z","month":"10","language":[{"iso":"eng"}],"date_updated":"2025-12-30T13:08:12Z","arxiv":1,"publisher":"Springer Nature","department":[{"_id":"ZoHa"}],"isi":1,"oa":1,"day":"01","status":"public","OA_type":"green","citation":{"ama":"Onoue M, Ding X, Silverman JD, et al. A post-starburst pathway for the formation of massive galaxies and black holes at z &#62; 6. <i>Nature Astronomy</i>. 2025;9:1541-1552. doi:<a href=\"https://doi.org/10.1038/s41550-025-02628-1\">10.1038/s41550-025-02628-1</a>","ista":"Onoue M, Ding X, Silverman JD, Matsuoka Y, Izumi T, Strauss MA, Ward C, Phillips CL, Ito K, Andika IT, Aoki K, Arita J, Baba S, Bieri R, Bosman SEI, Eilers AC, Fujimoto S, Habouzit M, Haiman Z, Imanishi M, Inayoshi K, Iwasawa K, Jahnke K, Kashikawa N, Kawaguchi T, Kohno K, Lee CH, Li J, Lupi A, Lyu J, Nagao T, Overzier R, Schindler JT, Schramm M, Scoggins MT, Shimasaku K, Toba Y, Trakhtenbrot B, Trebitsch M, Treu T, Umehata H, Venemans B, Vestergaard M, Volonteri M, Walter F, Wang F, Yang J, Zhang H. 2025. A post-starburst pathway for the formation of massive galaxies and black holes at z &#62; 6. Nature Astronomy. 9, 1541–1552.","short":"M. Onoue, X. Ding, J.D. Silverman, Y. Matsuoka, T. Izumi, M.A. Strauss, C. Ward, C.L. Phillips, K. Ito, I.T. Andika, K. Aoki, J. Arita, S. Baba, R. Bieri, S.E.I. Bosman, A.C. Eilers, S. Fujimoto, M. Habouzit, Z. Haiman, M. Imanishi, K. Inayoshi, K. Iwasawa, K. Jahnke, N. Kashikawa, T. Kawaguchi, K. Kohno, C.H. Lee, J. Li, A. Lupi, J. Lyu, T. Nagao, R. Overzier, J.T. Schindler, M. Schramm, M.T. Scoggins, K. Shimasaku, Y. Toba, B. Trakhtenbrot, M. Trebitsch, T. Treu, H. Umehata, B. Venemans, M. Vestergaard, M. Volonteri, F. Walter, F. Wang, J. Yang, H. Zhang, Nature Astronomy 9 (2025) 1541–1552.","ieee":"M. Onoue <i>et al.</i>, “A post-starburst pathway for the formation of massive galaxies and black holes at z &#62; 6,” <i>Nature Astronomy</i>, vol. 9. Springer Nature, pp. 1541–1552, 2025.","mla":"Onoue, Masafusa, et al. “A Post-Starburst Pathway for the Formation of Massive Galaxies and Black Holes at z &#62; 6.” <i>Nature Astronomy</i>, vol. 9, Springer Nature, 2025, pp. 1541–52, doi:<a href=\"https://doi.org/10.1038/s41550-025-02628-1\">10.1038/s41550-025-02628-1</a>.","apa":"Onoue, M., Ding, X., Silverman, J. D., Matsuoka, Y., Izumi, T., Strauss, M. A., … Zhang, H. (2025). A post-starburst pathway for the formation of massive galaxies and black holes at z &#62; 6. <i>Nature Astronomy</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41550-025-02628-1\">https://doi.org/10.1038/s41550-025-02628-1</a>","chicago":"Onoue, Masafusa, Xuheng Ding, John D. Silverman, Yoshiki Matsuoka, Takuma Izumi, Michael A. Strauss, Charlotte Ward, et al. “A Post-Starburst Pathway for the Formation of Massive Galaxies and Black Holes at z &#62; 6.” <i>Nature Astronomy</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41550-025-02628-1\">https://doi.org/10.1038/s41550-025-02628-1</a>."}},{"year":"2025","date_created":"2025-08-22T08:12:55Z","doi":"10.15479/AT-ISTA-20206","publication_identifier":{"issn":["2663-337X"]},"file":[{"file_id":"20228","file_size":39735535,"date_updated":"2025-08-25T13:49:55Z","access_level":"closed","checksum":"191db3367c19c9b32b65f4bc3a7c19de","relation":"source_file","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"2025_Vorlaufer_Jakob_Thesis.docx","date_created":"2025-08-25T13:49:55Z","creator":"jvorlauf"},{"file_id":"20229","relation":"main_file","checksum":"104400e6036921569610230c1d4899dc","access_level":"open_access","file_size":10947446,"date_updated":"2025-08-25T13:49:56Z","date_created":"2025-08-25T13:49:56Z","content_type":"application/pdf","file_name":"2025_Vorlaufer_Jakob_Thesis.pdf","creator":"jvorlauf","success":1}],"corr_author":"1","ddc":["621","535"],"has_accepted_license":"1","OA_place":"publisher","author":[{"last_name":"Vorlaufer","first_name":"Jakob","orcid":"0009-0000-7590-3501","id":"937696FA-C996-11E9-8C7C-CF13E6697425","full_name":"Vorlaufer, Jakob"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","related_material":{"record":[{"id":"19795","relation":"part_of_dissertation","status":"public"}]},"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"EM-Fac"},{"_id":"Bio"}],"abstract":[{"text":"The internal structure of biomolecules and their organization in higher-order arrangements are key factors governing the working principles of biological systems. Bioimaging has successfully revealed arrangements across relevant spatial scales. For example, cryo-electron tomography has become widely used for analyzing biomolecular structures in situ due to its comprehensive structural visualization of near-natively preserved samples, and its capability of sub-nm resolution via averaging. However, the identification of molecules within crowded cellular environments is often hindered by low contrast. Fluorescence microscopy, on the other hand, routinely visualizes specifically labeled targets at single-molecule contrast against essentially zero background. Moreover, it provides comparatively high throughput and is amenable to multiplexing. Due to this complementarity, combining datasets from both modalities acquired on the same region via correlative light and electron microscopy can reveal novel types of information. \r\nThe spatial scale at which information can be extracted depends on imaging resolution and correlation accuracy. Since diffraction of light limits the resolution of conventional fluorescence microscopy to few hundreds of nanometers, reaching the full potential of correlative imaging requires super-resolution approaches. Performing imaging at cryogenic temperature preserves structures in a near-native state and minimizes distortions between the fluorescence and the electron microscopy datasets. Implementations of this concept have achieved correlation on the scale of cellular organelles or bacterial domains.\r\nWe have worked towards pushing correlative imaging to the single-molecule scale by improving cryo-super-resolution microscopy, and devising a refined image correlation workflow. As part of this project, I constructed a microscopy setup and adopted it for super-resolution fluorescence microscopy at room temperature and cryogenic conditions. I explored different cryo-stages and acquisition strategies. Specifically, I developed a new scheme for correcting sample drift, thus increasing mechanical stability during microscopy acquisitions.\r\n","lang":"eng"}],"publication_status":"published","page":"107","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","article_processing_charge":"No","title":"Construction of a cryo-super-resolution microscope to guide in situ structure analysis","degree_awarded":"PhD","supervisor":[{"first_name":"Johann G","last_name":"Danzl","orcid":"0000-0001-8559-3973","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","full_name":"Danzl, Johann G"}],"tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"day":"25","status":"public","alternative_title":["ISTA Thesis"],"project":[{"name":"CryoMinflux-guided in-situ molecular census and structure determination","_id":"62909c6f-2b32-11ec-9570-e1476aab5308","grant_number":"CZI01"}],"citation":{"apa":"Vorlaufer, J. (2025). <i>Construction of a cryo-super-resolution microscope to guide in situ structure analysis</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20206\">https://doi.org/10.15479/AT-ISTA-20206</a>","chicago":"Vorlaufer, Jakob. “Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20206\">https://doi.org/10.15479/AT-ISTA-20206</a>.","mla":"Vorlaufer, Jakob. <i>Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20206\">10.15479/AT-ISTA-20206</a>.","short":"J. Vorlaufer, Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis, Institute of Science and Technology Austria, 2025.","ieee":"J. Vorlaufer, “Construction of a cryo-super-resolution microscope to guide in situ structure analysis,” Institute of Science and Technology Austria, 2025.","ama":"Vorlaufer J. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20206\">10.15479/AT-ISTA-20206</a>","ista":"Vorlaufer J. 2025. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. Institute of Science and Technology Austria."},"type":"dissertation","acknowledgement":"The project was supported by CZI grant DAF2021-234754 and grant\r\nDOI: https://doi.org/10.37921/812628ebpcwg from the Chan Zuckerberg Initiative DAF, an\r\nadvised fund of Silicon Valley Community Foundation (funder\r\nDOI: https://doi.org/10.13039/100014989), as well as internal grants from ISTA’s Equipment\r\nInvestment Committee and Interdisciplinary Project Committee. ","oa_version":"Published Version","_id":"20206","oa":1,"file_date_updated":"2025-08-25T13:49:56Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"JoDa"}],"date_updated":"2026-04-07T11:48:07Z","language":[{"iso":"eng"}],"month":"08","date_published":"2025-08-25T00:00:00Z"},{"date_updated":"2026-02-16T12:43:12Z","arxiv":1,"publisher":"IOP Publishing","department":[{"_id":"JoMa"}],"date_published":"2025-08-20T00:00:00Z","language":[{"iso":"eng"}],"month":"08","DOAJ_listed":"1","file_date_updated":"2025-09-02T06:40:23Z","oa":1,"isi":1,"scopus_import":"1","_id":"20217","acknowledgement":"The authors thank R. Cooper, G. Yang, V. Kokorev, D. Wen, C. Williams, and H. Übler for useful discussions and comments.\r\nE.I. and K.I.C. acknowledge funding from the Netherlands Research School for Astronomy (NOVA). K.I.C. acknowledges funding from the Dutch Research Council (NWO) through the award of the Vici grant VI.C.212.036. A.A.-H. acknowledges support from grant PID2021-124665NB-I00 funded by MCIN/AEI/10.13039/ 501100011033 and by “ERDF A way of making Europe.” P.G.P.-G. acknowledges support from grant PID2022-139567NB-I00 funded by the Spanish Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033, FEDER Una manera de hacer Europa. J.A.-M., A.C.-G., and L.C. acknowledge support by grant PIB2021-127718NB-100 from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe.” L.C. thanks the support from the Cosmic Dawn Center received during visits to DAWN as an international associate. L.C. acknowledges support by grants PIB2021-127718NB-100 and PID2022-139567NB-I00 from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe.” T.R.G. acknowledges support from the Carlsberg Foundation (grant No. CF20-0534). S.G. acknowledges financial support from the Cosmic Dawn Center (DAWN), funded by the Danish National Research Foundation (DNRF) under grant No. 140. This work was supported by research grants (VIL16599, VIL54489) from VILLUM FONDEN. J.P.P. and T.V.T. acknowledge financial support from the UK Science and Technology Facilities Council and the UK Space Agency.\r\n\r\nThis work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the MAST at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs GO #1963, GO #1895, and GTO #1283. The authors acknowledge the team led by co-PIs: C. Williams, M. Maseda, and S. Tacchella, and PI P. Oesch, for developing their respective observing programs with a zero-exclusive-access period. Also based on observations made with the NASA/ESA HST obtained from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. The work presented here is the effort of the entire MIRI team, and the enthusiasm within the MIRI partnership is a significant factor in its success. MIRI draws on the scientific and technical expertise of the following organizations: Ames Research Center, USA; Airbus Defence and Space, UK; CEA-Irfu, Saclay, France; Centre Spatial de Liège, Belgium; Consejo Superior de Investigaciones Científicas, Spain; Carl Zeiss Optronics, Germany; Chalmers University of Technology, Sweden; Danish Space Research Institute, Denmark; Dublin Institute for Advanced Studies, Ireland; European Space Agency, Netherlands; ETCA, Belgium; ETH Zurich, Switzerland; Goddard Space Flight Center, USA; Institute d’Astrophysique Spatiale, France; Instituto Nacional de Técnica Aeroespacial, Spain; Institute for Astronomy, Edinburgh, UK; Jet Propulsion Laboratory, USA; Laboratoire d’Astrophysique de Marseille (LAM), France; Leiden University, Netherlands; Lockheed Advanced Technology Center (USA); NOVA Opt-IR group at Dwingeloo, Netherlands; Northrop Grumman, USA; Max-Planck Institut für Astronomie (MPIA), Heidelberg, Germany; Laboratoire d’Etudes Spatiales et d’Instrumentation en Astrophysique (LESIA), France; Paul Scherrer Institut, Switzerland; Raytheon Vision Systems, USA; RUAG Aerospace, Switzerland; Rutherford Appleton Laboratory (RAL Space), UK; Space Telescope Science Institute, USA; Toegepast-Natuurwetenschappelijk Onderzoek (TNO-TPD), Netherlands; UK Astronomy Technology Centre, UK; University College London, UK; University of Amsterdam, Netherlands; University of Arizona, USA; University of Cardiff, UK; University of Cologne, Germany; University of Ghent; University of Groningen, Netherlands; University of Leicester, UK; University of Leuven, Belgium; University of Stockholm, Sweden; Utah State University, USA.\r\nFor the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to the Author Accepted Manuscript version arising from this submission.","type":"journal_article","intvolume":"       989","oa_version":"Published Version","article_type":"original","citation":{"ista":"Iani E, Rinaldi P, Caputi KI, Annunziatella M, Langeroodi D, Melinder J, Pérez-González PG, Álvarez-Márquez J, Boogaard LA, Bosman SEI, Costantin L, Moutard T, Colina L, Östlin G, Greve TR, Wright G, Alonso-Herrero A, Bik A, Gillman S, Crespo Gómez A, Hjorth J, Kendrew S, Labiano A, Pye JP, Tikkanen TV, Walter F, Güdel M, Henning T, Van Der Werf PP. 2025. MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. The Astrophysical Journal. 989(2), 160.","ama":"Iani E, Rinaldi P, Caputi KI, et al. MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. <i>The Astrophysical Journal</i>. 2025;989(2). doi:<a href=\"https://doi.org/10.3847/1538-4357/ade5a6\">10.3847/1538-4357/ade5a6</a>","short":"E. Iani, P. Rinaldi, K.I. Caputi, M. Annunziatella, D. Langeroodi, J. Melinder, P.G. Pérez-González, J. Álvarez-Márquez, L.A. Boogaard, S.E.I. Bosman, L. Costantin, T. Moutard, L. Colina, G. Östlin, T.R. Greve, G. Wright, A. Alonso-Herrero, A. Bik, S. Gillman, A. Crespo Gómez, J. Hjorth, S. Kendrew, A. Labiano, J.P. Pye, T.V. Tikkanen, F. Walter, M. Güdel, T. Henning, P.P. Van Der Werf, The Astrophysical Journal 989 (2025).","ieee":"E. Iani <i>et al.</i>, “MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6,” <i>The Astrophysical Journal</i>, vol. 989, no. 2. IOP Publishing, 2025.","mla":"Iani, Edoardo, et al. “MIDIS: MIRI Uncovers Virgil, the First Little Red Dot with Clear Detection of Its Host Galaxy at z ≃ 6.6.” <i>The Astrophysical Journal</i>, vol. 989, no. 2, 160, IOP Publishing, 2025, doi:<a href=\"https://doi.org/10.3847/1538-4357/ade5a6\">10.3847/1538-4357/ade5a6</a>.","apa":"Iani, E., Rinaldi, P., Caputi, K. I., Annunziatella, M., Langeroodi, D., Melinder, J., … Van Der Werf, P. P. (2025). MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ade5a6\">https://doi.org/10.3847/1538-4357/ade5a6</a>","chicago":"Iani, Edoardo, Pierluigi Rinaldi, Karina I. Caputi, Marianna Annunziatella, Danial Langeroodi, Jens Melinder, Pablo G. Pérez-González, et al. “MIDIS: MIRI Uncovers Virgil, the First Little Red Dot with Clear Detection of Its Host Galaxy at z ≃ 6.6.” <i>The Astrophysical Journal</i>. IOP Publishing, 2025. <a href=\"https://doi.org/10.3847/1538-4357/ade5a6\">https://doi.org/10.3847/1538-4357/ade5a6</a>."},"PlanS_conform":"1","day":"20","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"OA_type":"gold","title":"MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6","external_id":{"arxiv":["2406.18207"],"isi":["001548132000001"]},"publication_status":"published","abstract":[{"lang":"eng","text":"We present Virgil, a Mid-Infrared Instrument (MIRI) extremely red object detected with the F1000W filter as part of the MIRI Deep Imaging Survey observations of the Hubble Ultra Deep Field. Virgil is an Lyα emitter (LAE) at zspec = 6.6312 ± 0.0019 (from the Very Large Telescope/MUSE) with a rest-frame UV-to-optical spectral energy distribution (SED) typical of LAEs at similar redshifts. However, MIRI observations reveal an unexpected extremely red color at rest-frame near-infrared (NIR) wavelengths, F444W − F1000W = 2.33 ± 0.06. Such a steep\r\nrise in the NIR, completely missed without MIRI imaging, is poorly reproduced by models including only stellar populations and hints toward the presence of an active galactic nucleus, although alternative explanations such as extreme dust obscuration and strong nebular continuum and emission lines contribution due to young stellar ages cannot be completely ruled out. According to the shape of its overall SED, Virgil belongs to the recently discovered\r\npopulation of little red dots but displays an extended rest-frame UV-optical wavelength morphology following a 2DSérsic profile with an average index of n = 0.93+0.85_0.31 and re = 0.49+0.05_0.11  pkpc. Only at MIRI wavelengths, Virgil is unresolved due to the coarser point-spread function. This discovery demonstrates the crucial importance of deep MIRI surveys to reveal the true nature and properties of high-z galaxies that otherwise would be misinterpreted and raises the question of how common Virgil-like objects could be in the early Universe."}],"article_processing_charge":"Yes","OA_place":"publisher","volume":989,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Edoardo","last_name":"Iani","full_name":"Iani, Edoardo","id":"4053390a-6b68-11ef-9828-a3b8adef8d0a","orcid":"0000-0001-8386-3546"},{"full_name":"Rinaldi, Pierluigi","first_name":"Pierluigi","last_name":"Rinaldi"},{"full_name":"Caputi, Karina I.","last_name":"Caputi","first_name":"Karina I."},{"first_name":"Marianna","last_name":"Annunziatella","full_name":"Annunziatella, Marianna"},{"full_name":"Langeroodi, Danial","first_name":"Danial","last_name":"Langeroodi"},{"full_name":"Melinder, Jens","first_name":"Jens","last_name":"Melinder"},{"full_name":"Pérez-González, Pablo G.","last_name":"Pérez-González","first_name":"Pablo G."},{"first_name":"Javier","last_name":"Álvarez-Márquez","full_name":"Álvarez-Márquez, Javier"},{"last_name":"Boogaard","first_name":"Leindert A.","full_name":"Boogaard, Leindert A."},{"first_name":"Sarah E.I.","last_name":"Bosman","full_name":"Bosman, Sarah E.I."},{"full_name":"Costantin, Luca","first_name":"Luca","last_name":"Costantin"},{"full_name":"Moutard, Thibaud","last_name":"Moutard","first_name":"Thibaud"},{"first_name":"Luis","last_name":"Colina","full_name":"Colina, Luis"},{"last_name":"Östlin","first_name":"Göran","full_name":"Östlin, Göran"},{"full_name":"Greve, Thomas R.","first_name":"Thomas R.","last_name":"Greve"},{"last_name":"Wright","first_name":"Gillian","full_name":"Wright, Gillian"},{"last_name":"Alonso-Herrero","first_name":"Almudena","full_name":"Alonso-Herrero, Almudena"},{"first_name":"Arjan","last_name":"Bik","full_name":"Bik, Arjan"},{"last_name":"Gillman","first_name":"Steven","full_name":"Gillman, Steven"},{"first_name":"Alejandro","last_name":"Crespo Gómez","full_name":"Crespo Gómez, Alejandro"},{"full_name":"Hjorth, Jens","first_name":"Jens","last_name":"Hjorth"},{"last_name":"Kendrew","first_name":"Sarah","full_name":"Kendrew, Sarah"},{"full_name":"Labiano, Alvaro","first_name":"Alvaro","last_name":"Labiano"},{"full_name":"Pye, John P.","last_name":"Pye","first_name":"John P."},{"last_name":"Tikkanen","first_name":"Tuomo V.","full_name":"Tikkanen, Tuomo V."},{"full_name":"Walter, Fabian","last_name":"Walter","first_name":"Fabian"},{"full_name":"Güdel, Manuel","last_name":"Güdel","first_name":"Manuel"},{"full_name":"Henning, Thomas","first_name":"Thomas","last_name":"Henning"},{"first_name":"Paul P.","last_name":"Van Der Werf","full_name":"Van Der Werf, Paul P."}],"ddc":["520"],"has_accepted_license":"1","file":[{"file_name":"2025_AstrophysicalJour_Iani.pdf","content_type":"application/pdf","date_created":"2025-09-02T06:40:23Z","success":1,"creator":"dernst","file_id":"20268","file_size":5474992,"date_updated":"2025-09-02T06:40:23Z","access_level":"open_access","checksum":"92196e8352dddb1f305c253da1996ab6","relation":"main_file"}],"quality_controlled":"1","publication":"The Astrophysical Journal","doi":"10.3847/1538-4357/ade5a6","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"issue":"2","article_number":"160","date_created":"2025-08-24T22:01:29Z","year":"2025"},{"ddc":["580"],"has_accepted_license":"1","quality_controlled":"1","file":[{"access_level":"open_access","relation":"main_file","checksum":"0f1ae246acc9b075f01bf4afe382c8ba","file_size":10876817,"date_updated":"2025-09-02T07:05:37Z","file_id":"20270","success":1,"creator":"dernst","date_created":"2025-09-02T07:05:37Z","file_name":"2025_ScienceAdvance_DeJaegerBraet.pdf","content_type":"application/pdf"}],"publication":"Science Advances","issue":"32","publication_identifier":{"eissn":["2375-2548"]},"doi":"10.1126/sciadv.adr5694","year":"2025","date_created":"2025-08-24T22:01:30Z","title":"The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat","abstract":[{"lang":"eng","text":"Stress granules (SG) are biomolecular condensates that represent an adaptive response of cells to various stresses, including heat. However, the cell type–specific function and relevance of SG formation, especially during reproductive development, are largely not understood. Here, we show that the meiotic A-type cyclin TARDY ASYNCHRONOUS MEIOSIS (TAM) is recruited to SGs in male meiocytes of Arabidopsis after exposure to heat. We find that the amino terminus of TAM is necessary and sufficient for the localization of proteins to meiotic SGs. Swapping the amino terminus of TAM with the one of its sister protein CYCA1;1 resulted in a separation-of-function allele of TAM, which prevents the partitioning of TAM to SGs while restoring a wild-type phenotype in a tam mutant background under nonheat stress conditions. Notably, plants expressing this TAM version prematurely terminate meiosis under heat resulting in unreduced gametes. Thus, the formation of TAM-containing SGs is necessary for genome stability under heat stress."}],"external_id":{"isi":["001549102600016"]},"publication_status":"published","page":"eadr5694","article_processing_charge":"Yes","acknowledged_ssus":[{"_id":"Bio"}],"OA_place":"publisher","volume":11,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","author":[{"first_name":"Joke G","last_name":"De Jaeger-Braet","id":"26bd38d3-c59a-11ee-a1af-d7a988cafcc5","full_name":"De Jaeger-Braet, Joke G"},{"full_name":"Hartmann, Merle","first_name":"Merle","last_name":"Hartmann"},{"full_name":"Böttger, Lev","first_name":"Lev","last_name":"Böttger"},{"id":"082e3e6e-8069-11ed-8390-c8cce7b1aaca","full_name":"Yang, Chao","last_name":"Yang","first_name":"Chao"},{"full_name":"Hamada, Takahiro","first_name":"Takahiro","last_name":"Hamada"},{"full_name":"Hoth, Stefan","first_name":"Stefan","last_name":"Hoth"},{"last_name":"Feng","first_name":"Xiaoqi","full_name":"Feng, Xiaoqi","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","orcid":"0000-0002-4008-1234"},{"full_name":"Weingartner, Magdalena","last_name":"Weingartner","first_name":"Magdalena"},{"full_name":"Schnittger, Arp","last_name":"Schnittger","first_name":"Arp"}],"project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program"}],"citation":{"ama":"De Jaeger-Braet JG, Hartmann M, Böttger L, et al. The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. <i>Science Advances</i>. 2025;11(32):eadr5694. doi:<a href=\"https://doi.org/10.1126/sciadv.adr5694\">10.1126/sciadv.adr5694</a>","ista":"De Jaeger-Braet JG, Hartmann M, Böttger L, Yang C, Hamada T, Hoth S, Feng X, Weingartner M, Schnittger A. 2025. The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. Science Advances. 11(32), eadr5694.","ieee":"J. G. De Jaeger-Braet <i>et al.</i>, “The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat,” <i>Science Advances</i>, vol. 11, no. 32. AAAS, p. eadr5694, 2025.","short":"J.G. De Jaeger-Braet, M. Hartmann, L. Böttger, C. Yang, T. Hamada, S. Hoth, X. Feng, M. Weingartner, A. Schnittger, Science Advances 11 (2025) eadr5694.","mla":"De Jaeger-Braet, Joke G., et al. “The Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” <i>Science Advances</i>, vol. 11, no. 32, AAAS, 2025, p. eadr5694, doi:<a href=\"https://doi.org/10.1126/sciadv.adr5694\">10.1126/sciadv.adr5694</a>.","chicago":"De Jaeger-Braet, Joke G, Merle Hartmann, Lev Böttger, Chao Yang, Takahiro Hamada, Stefan Hoth, Xiaoqi Feng, Magdalena Weingartner, and Arp Schnittger. “The Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” <i>Science Advances</i>. AAAS, 2025. <a href=\"https://doi.org/10.1126/sciadv.adr5694\">https://doi.org/10.1126/sciadv.adr5694</a>.","apa":"De Jaeger-Braet, J. G., Hartmann, M., Böttger, L., Yang, C., Hamada, T., Hoth, S., … Schnittger, A. (2025). The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.adr5694\">https://doi.org/10.1126/sciadv.adr5694</a>"},"status":"public","day":"08","OA_type":"gold","ec_funded":1,"tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"department":[{"_id":"XiFe"}],"publisher":"AAAS","date_updated":"2025-09-30T14:24:10Z","month":"08","language":[{"iso":"eng"}],"date_published":"2025-08-08T00:00:00Z","oa":1,"file_date_updated":"2025-09-02T07:05:37Z","DOAJ_listed":"1","isi":1,"_id":"20220","scopus_import":"1","acknowledgement":"We thank L. Strader (Duke University, Durham) and A. Holehouse (Washington University, Saint Louis) for discussion and input in LLPS. We thank T. Nakagawa (Shimane University, Matsue) for providing the pGWB604 Gateway vector containing bar gene identified by Meiji Seika Kaisha Ltd. We thank M. Heese (Hamburg University) for the critical reading and comments on this manuscript. We further thank J. Mehrmann (Hamburg University) for technical assistance. We thank the ISTA imaging facility for assistance for microscopy.\r\nThis project has received funding from JST-PRESTO (JPMJPR18H7), JST-CREST (JPMJCR18H4), European Union’s Horizon 2020 under MSCA grant 101034413, and a federal grant from the state of Hamburg (LFF-BiCon).","type":"journal_article","article_type":"original","oa_version":"Published Version","intvolume":"        11"},{"PlanS_conform":"1","citation":{"ista":"Shi W, Wang M, Venkataraman L, Tovar JD. 2025. Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction. Nano Letters. 25(31), 12101–12106.","ama":"Shi W, Wang M, Venkataraman L, Tovar JD. Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction. <i>Nano Letters</i>. 2025;25(31):12101-12106. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5c03693\">10.1021/acs.nanolett.5c03693</a>","ieee":"W. Shi, M. Wang, L. Venkataraman, and J. D. Tovar, “Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction,” <i>Nano Letters</i>, vol. 25, no. 31. American Chemical Society, pp. 12101–12106, 2025.","short":"W. Shi, M. Wang, L. Venkataraman, J.D. Tovar, Nano Letters 25 (2025) 12101–12106.","mla":"Shi, Wanzhuo, et al. “Single-Molecule Conductance through Hybrid Radially and Linearly π-Conjugated Macromolecules Reveals an Unusual Intramolecular π-Interaction.” <i>Nano Letters</i>, vol. 25, no. 31, American Chemical Society, 2025, pp. 12101–06, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.5c03693\">10.1021/acs.nanolett.5c03693</a>.","apa":"Shi, W., Wang, M., Venkataraman, L., &#38; Tovar, J. D. (2025). Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.5c03693\">https://doi.org/10.1021/acs.nanolett.5c03693</a>","chicago":"Shi, Wanzhuo, Mengjiao Wang, Latha Venkataraman, and John D. Tovar. “Single-Molecule Conductance through Hybrid Radially and Linearly π-Conjugated Macromolecules Reveals an Unusual Intramolecular π-Interaction.” <i>Nano Letters</i>. American Chemical Society, 2025. <a href=\"https://doi.org/10.1021/acs.nanolett.5c03693\">https://doi.org/10.1021/acs.nanolett.5c03693</a>."},"OA_type":"hybrid","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","day":"24","isi":1,"oa":1,"file_date_updated":"2025-09-02T06:50:11Z","language":[{"iso":"eng"}],"month":"07","date_published":"2025-07-24T00:00:00Z","publisher":"American Chemical Society","department":[{"_id":"LaVe"}],"date_updated":"2025-09-30T14:23:39Z","article_type":"original","oa_version":"Published Version","intvolume":"        25","acknowledgement":"We thank Prof. Volker Blum for useful discussions. We thank the Department of Energy Office of Basic Energy Science (DE-SC0019017) and the National Science Foundation (NSF-DMR 2241180) for supporting this research. This work was supported in part by the Institute of Science and Technology Austria.","type":"journal_article","_id":"20221","scopus_import":"1","corr_author":"1","file":[{"file_id":"20269","access_level":"open_access","relation":"main_file","checksum":"bfc167d8904c0c47c3de2a8d0ec699d5","date_updated":"2025-09-02T06:50:11Z","file_size":3212706,"date_created":"2025-09-02T06:50:11Z","file_name":"2025_NanoLetters_Shi.pdf","content_type":"application/pdf","success":1,"creator":"dernst"}],"quality_controlled":"1","has_accepted_license":"1","ddc":["540"],"year":"2025","date_created":"2025-08-24T22:01:30Z","issue":"31","publication_identifier":{"eissn":["1530-6992"]},"doi":"10.1021/acs.nanolett.5c03693","publication":"Nano Letters","page":"12101-12106","article_processing_charge":"Yes (via OA deal)","abstract":[{"text":"We describe the design, synthesis, and single-molecule junction conductance of π-electron molecules bearing both radial and linear π-conjugation pathways, whereby cycloparaphenylene (CPP) radial cores are π-extended linearly with aryl alkyne substituents as models for previously reported CPP-arylene ethynylene conjugated polymers. Although radially and linearly conjugated molecules have been studied previously in isolation as junction-bridging molecular electronic units, this is the first study to examine molecules where both topologies are operative. Our results reveal that the presence of radial CPP components within the junction-spanning pathway leads to a reduction in the conductance of the backbone compared to model linear phenyl substituents. Through tight-binding and DFT-based calculations, we attribute this conductance change to intramolecular van der Waals (vdW) interactions between the CPP ring and the junction-spanning arylene-ethynylene molecular backbone. These interactions induce changes in the dihedral angles of the backbone, leading to a reduced overlap of π orbitals within the molecular junction.","lang":"eng"}],"external_id":{"isi":["001537145800001"],"pmid":["40707400"]},"publication_status":"published","title":"Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","author":[{"full_name":"Shi, Wanzhuo","id":"a3010425-87c8-11f0-8106-bec32bea74da","first_name":"Wanzhuo","last_name":"Shi"},{"last_name":"Wang","first_name":"Mengjiao","full_name":"Wang, Mengjiao"},{"id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","orcid":"0000-0002-6957-6089","full_name":"Venkataraman, Latha","last_name":"Venkataraman","first_name":"Latha"},{"last_name":"Tovar","first_name":"John D.","full_name":"Tovar, John D."}],"volume":25,"OA_place":"publisher","pmid":1}]