---
_id: '15057'
abstract:
- lang: eng
text: Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear
protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions
in cell division and germline proliferation. However, the role of VRK-1 in postmitotic
cells and adult life span remains unknown. Here, we show that VRK-1 increases
organismal longevity by activating the cellular energy sensor, AMP-activated protein
kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1
in the soma of adult C. elegans increased life span and, conversely, inhibition
of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred
by mutations that inhibit C. elegans mitochondrial respiration, which requires
AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and
cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1,
promotes longevity through AMPK activation, and this function appears to be conserved
between C. elegans and humans.
acknowledgement: 'This research was supported by grants NRF-2019R1A3B2067745 and NRF-2017R1A5A1015366
funded by the Korean Government (MSIT) through the National Research Foundation
(NRF) of Korea to S.-J.V.L. and by grant Basic Science Research Program (No. 2019R1A2C2009440)
funded by the Korean Government (MSIT) through the NRF of Korea to K.-T.K. '
article_number: aaw7824
article_processing_charge: No
article_type: original
author:
- first_name: Sangsoon
full_name: Park, Sangsoon
last_name: Park
- first_name: Murat
full_name: Artan, Murat
id: C407B586-6052-11E9-B3AE-7006E6697425
last_name: Artan
orcid: 0000-0001-8945-6992
- first_name: Seung Hyun
full_name: Han, Seung Hyun
last_name: Han
- first_name: Hae-Eun H.
full_name: Park, Hae-Eun H.
last_name: Park
- first_name: Yoonji
full_name: Jung, Yoonji
last_name: Jung
- first_name: Ara B.
full_name: Hwang, Ara B.
last_name: Hwang
- first_name: Won Sik
full_name: Shin, Won Sik
last_name: Shin
- first_name: Kyong-Tai
full_name: Kim, Kyong-Tai
last_name: Kim
- first_name: Seung-Jae V.
full_name: Lee, Seung-Jae V.
last_name: Lee
citation:
ama: Park S, Artan M, Han SH, et al. VRK-1 extends life span by activation of AMPK
via phosphorylation. Science Advances. 2020;6(27). doi:10.1126/sciadv.aaw7824
apa: Park, S., Artan, M., Han, S. H., Park, H.-E. H., Jung, Y., Hwang, A. B., …
Lee, S.-J. V. (2020). VRK-1 extends life span by activation of AMPK via phosphorylation.
Science Advances. American Association for the Advancement of Science.
https://doi.org/10.1126/sciadv.aaw7824
chicago: Park, Sangsoon, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung,
Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, and Seung-Jae V. Lee. “VRK-1 Extends
Life Span by Activation of AMPK via Phosphorylation.” Science Advances.
American Association for the Advancement of Science, 2020. https://doi.org/10.1126/sciadv.aaw7824.
ieee: S. Park et al., “VRK-1 extends life span by activation of AMPK via
phosphorylation,” Science Advances, vol. 6, no. 27. American Association
for the Advancement of Science, 2020.
ista: Park S, Artan M, Han SH, Park H-EH, Jung Y, Hwang AB, Shin WS, Kim K-T, Lee
S-JV. 2020. VRK-1 extends life span by activation of AMPK via phosphorylation.
Science Advances. 6(27), aaw7824.
mla: Park, Sangsoon, et al. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.”
Science Advances, vol. 6, no. 27, aaw7824, American Association for the
Advancement of Science, 2020, doi:10.1126/sciadv.aaw7824.
short: S. Park, M. Artan, S.H. Han, H.-E.H. Park, Y. Jung, A.B. Hwang, W.S. Shin,
K.-T. Kim, S.-J.V. Lee, Science Advances 6 (2020).
date_created: 2024-03-04T09:41:57Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2024-03-04T09:52:09Z
day: '01'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1126/sciadv.aaw7824
file:
- access_level: open_access
checksum: a37157cd0de709dce5fe03f4a31cd0b6
content_type: application/pdf
creator: dernst
date_created: 2024-03-04T09:46:41Z
date_updated: 2024-03-04T09:46:41Z
file_id: '15058'
file_name: 2020_ScienceAdvances_Park.pdf
file_size: 1864415
relation: main_file
success: 1
file_date_updated: 2024-03-04T09:46:41Z
has_accepted_license: '1'
intvolume: ' 6'
issue: '27'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: VRK-1 extends life span by activation of AMPK via phosphorylation
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2020'
...
---
_id: '15061'
abstract:
- lang: eng
text: The actin cytoskeleton, a dynamic network of actin filaments and associated
F-actin–binding proteins, is fundamentally important in eukaryotes. α-Actinins
are major F-actin bundlers that are inhibited by Ca2+ in nonmuscle cells. Here
we report the mechanism of Ca2+-mediated regulation of Entamoeba histolytica α-actinin-2
(EhActn2) with features expected for the common ancestor of Entamoeba and higher
eukaryotic α-actinins. Crystal structures of Ca2+-free and Ca2+-bound EhActn2
reveal a calmodulin-like domain (CaMD) uniquely inserted within the rod domain.
Integrative studies reveal an exceptionally high affinity of the EhActn2 CaMD
for Ca2+, binding of which can only be regulated in the presence of physiological
concentrations of Mg2+. Ca2+ binding triggers an increase in protein multidomain
rigidity, reducing conformational flexibility of F-actin–binding domains via interdomain
cross-talk and consequently inhibiting F-actin bundling. In vivo studies uncover
that EhActn2 plays an important role in phagocytic cup formation and might constitute
a new drug target for amoebic dysentery.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: "We thank the staff of the macromolecular crystallography (MX) and
SAXS beamlines at the European Synchrotron Radiation facility, Diamond, and Swiss
Light Source for excellent support, and the Life Sciences Facility of the Institute
of Science and Technology Austria for usage of the rheometer. We thank Life Sciences
editors for editing assistance. EM data were\r\nrecorded at the EM Facility of the
Vienna BioCenter Core Facilities (Austria). Confocal microscopy was carried out
at the Advanced Instrument Research Facility, Jawaharlal Nehru University. K.D.-C.’s
research was supported by the Initial Training Network MUZIC (ITN-MUZIC) (N°238423),
Austrian Science Fund (FWF) Projects I525, I1593, P22276, P19060, and W1221, Laura
Bassi Centre of Optimized Structural Studies (N°253275), a Wellcome Trust Collaborative
Award (201543/Z/16/Z), COST Action BM1405, Vienna Science and Technology Fund (WWTF)
Chemical Biology Project LS17-008, and Christian Doppler Laboratory for High-Content
Structural Biology and Biotechnology. K.Z., J.L.A., C.S., E.A.G., and A.S. were
supported by the University of Vienna, J.K. by a Wellcome Trust Collaborative Award
and by the Centre of Optimized Structural Studies, M.P. by FWF Project I1593, E.d.A.R.
ITN-MUZIC, and FWF Projects I525 and I1593, and T.C.M. and L.C. by FWF Project I
2408-B22. E.A.G. acknowledges the PhD program Structure and Interaction of Biological
Macromolecules. M.B. acknowledges the University Grant Commission, India, for a
senior research fellowship. A.B. acknowledges a JC Bose Fellowship from the Science
Engineering Research Council. "
article_processing_charge: No
article_type: original
author:
- first_name: Nikos
full_name: Pinotsis, Nikos
last_name: Pinotsis
- first_name: Karolina
full_name: Zielinska, Karolina
last_name: Zielinska
- first_name: Mrigya
full_name: Babuta, Mrigya
last_name: Babuta
- first_name: Joan L.
full_name: Arolas, Joan L.
last_name: Arolas
- first_name: Julius
full_name: Kostan, Julius
last_name: Kostan
- first_name: Muhammad Bashir
full_name: Khan, Muhammad Bashir
last_name: Khan
- first_name: Claudia
full_name: Schreiner, Claudia
last_name: Schreiner
- first_name: Anita P
full_name: Testa Salmazo, Anita P
id: 41F1F098-F248-11E8-B48F-1D18A9856A87
last_name: Testa Salmazo
- first_name: Luciano
full_name: Ciccarelli, Luciano
last_name: Ciccarelli
- first_name: Martin
full_name: Puchinger, Martin
last_name: Puchinger
- first_name: Eirini A.
full_name: Gkougkoulia, Eirini A.
last_name: Gkougkoulia
- first_name: Euripedes de Almeida
full_name: Ribeiro, Euripedes de Almeida
last_name: Ribeiro
- first_name: Thomas C.
full_name: Marlovits, Thomas C.
last_name: Marlovits
- first_name: Alok
full_name: Bhattacharya, Alok
last_name: Bhattacharya
- first_name: Kristina
full_name: Djinovic-Carugo, Kristina
last_name: Djinovic-Carugo
citation:
ama: Pinotsis N, Zielinska K, Babuta M, et al. Calcium modulates the domain flexibility
and function of an α-actinin similar to the ancestral α-actinin. Proceedings
of the National Academy of Sciences. 2020;117(36):22101-22112. doi:10.1073/pnas.1917269117
apa: Pinotsis, N., Zielinska, K., Babuta, M., Arolas, J. L., Kostan, J., Khan, M.
B., … Djinovic-Carugo, K. (2020). Calcium modulates the domain flexibility and
function of an α-actinin similar to the ancestral α-actinin. Proceedings of
the National Academy of Sciences. Proceedings of the National Academy of Sciences.
https://doi.org/10.1073/pnas.1917269117
chicago: Pinotsis, Nikos, Karolina Zielinska, Mrigya Babuta, Joan L. Arolas, Julius
Kostan, Muhammad Bashir Khan, Claudia Schreiner, et al. “Calcium Modulates the
Domain Flexibility and Function of an α-Actinin Similar to the Ancestral α-Actinin.”
Proceedings of the National Academy of Sciences. Proceedings of the National
Academy of Sciences, 2020. https://doi.org/10.1073/pnas.1917269117.
ieee: N. Pinotsis et al., “Calcium modulates the domain flexibility and function
of an α-actinin similar to the ancestral α-actinin,” Proceedings of the National
Academy of Sciences, vol. 117, no. 36. Proceedings of the National Academy
of Sciences, pp. 22101–22112, 2020.
ista: Pinotsis N, Zielinska K, Babuta M, Arolas JL, Kostan J, Khan MB, Schreiner
C, Testa Salmazo AP, Ciccarelli L, Puchinger M, Gkougkoulia EA, Ribeiro E de A,
Marlovits TC, Bhattacharya A, Djinovic-Carugo K. 2020. Calcium modulates the domain
flexibility and function of an α-actinin similar to the ancestral α-actinin. Proceedings
of the National Academy of Sciences. 117(36), 22101–22112.
mla: Pinotsis, Nikos, et al. “Calcium Modulates the Domain Flexibility and Function
of an α-Actinin Similar to the Ancestral α-Actinin.” Proceedings of the National
Academy of Sciences, vol. 117, no. 36, Proceedings of the National Academy
of Sciences, 2020, pp. 22101–12, doi:10.1073/pnas.1917269117.
short: N. Pinotsis, K. Zielinska, M. Babuta, J.L. Arolas, J. Kostan, M.B. Khan,
C. Schreiner, A.P. Testa Salmazo, L. Ciccarelli, M. Puchinger, E.A. Gkougkoulia,
E. de A. Ribeiro, T.C. Marlovits, A. Bhattacharya, K. Djinovic-Carugo, Proceedings
of the National Academy of Sciences 117 (2020) 22101–22112.
date_created: 2024-03-04T10:03:52Z
date_published: 2020-09-08T00:00:00Z
date_updated: 2024-03-04T10:14:44Z
day: '08'
department:
- _id: CaBe
doi: 10.1073/pnas.1917269117
external_id:
pmid:
- '32848067'
intvolume: ' 117'
issue: '36'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1073/pnas.191726911
month: '09'
oa: 1
oa_version: Published Version
page: 22101-22112
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
status: public
title: Calcium modulates the domain flexibility and function of an α-actinin similar
to the ancestral α-actinin
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 117
year: '2020'
...
---
_id: '15064'
abstract:
- lang: eng
text: We call a continuous self-map that reveals itself through a discrete set of
point-value pairs a sampled dynamical system. Capturing the available information
with chain maps on Delaunay complexes, we use persistent homology to quantify
the evidence of recurrent behavior. We establish a sampling theorem to recover
the eigenspaces of the endomorphism on homology induced by the self-map. Using
a combinatorial gradient flow arising from the discrete Morse theory for Čech
and Delaunay complexes, we construct a chain map to transform the problem from
the natural but expensive Čech complexes to the computationally efficient Delaunay
triangulations. The fast chain map algorithm has applications beyond dynamical
systems.
acknowledgement: This research has been supported by the DFG Collaborative Research
Center SFB/TRR 109 “Discretization in Geometry and Dynamics”, by Polish MNiSzW Grant
No. 2621/7.PR/12/2013/2, by the Polish National Science Center under Maestro Grant
No. 2014/14/A/ST1/00453 and Grant No. DEC-2013/09/N/ST6/02995. Open Access funding
provided by Projekt DEAL.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: U.
full_name: Bauer, U.
last_name: Bauer
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Grzegorz
full_name: Jablonski, Grzegorz
id: 4483EF78-F248-11E8-B48F-1D18A9856A87
last_name: Jablonski
orcid: 0000-0002-3536-9866
- first_name: M.
full_name: Mrozek, M.
last_name: Mrozek
citation:
ama: Bauer U, Edelsbrunner H, Jablonski G, Mrozek M. Čech-Delaunay gradient flow
and homology inference for self-maps. Journal of Applied and Computational
Topology. 2020;4(4):455-480. doi:10.1007/s41468-020-00058-8
apa: Bauer, U., Edelsbrunner, H., Jablonski, G., & Mrozek, M. (2020). Čech-Delaunay
gradient flow and homology inference for self-maps. Journal of Applied and
Computational Topology. Springer Nature. https://doi.org/10.1007/s41468-020-00058-8
chicago: Bauer, U., Herbert Edelsbrunner, Grzegorz Jablonski, and M. Mrozek. “Čech-Delaunay
Gradient Flow and Homology Inference for Self-Maps.” Journal of Applied and
Computational Topology. Springer Nature, 2020. https://doi.org/10.1007/s41468-020-00058-8.
ieee: U. Bauer, H. Edelsbrunner, G. Jablonski, and M. Mrozek, “Čech-Delaunay gradient
flow and homology inference for self-maps,” Journal of Applied and Computational
Topology, vol. 4, no. 4. Springer Nature, pp. 455–480, 2020.
ista: Bauer U, Edelsbrunner H, Jablonski G, Mrozek M. 2020. Čech-Delaunay gradient
flow and homology inference for self-maps. Journal of Applied and Computational
Topology. 4(4), 455–480.
mla: Bauer, U., et al. “Čech-Delaunay Gradient Flow and Homology Inference for Self-Maps.”
Journal of Applied and Computational Topology, vol. 4, no. 4, Springer
Nature, 2020, pp. 455–80, doi:10.1007/s41468-020-00058-8.
short: U. Bauer, H. Edelsbrunner, G. Jablonski, M. Mrozek, Journal of Applied and
Computational Topology 4 (2020) 455–480.
date_created: 2024-03-04T10:47:49Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-03-04T10:54:04Z
day: '01'
ddc:
- '500'
department:
- _id: HeEd
doi: 10.1007/s41468-020-00058-8
file:
- access_level: open_access
checksum: eed1168b6e66cd55272c19bb7fca8a1c
content_type: application/pdf
creator: dernst
date_created: 2024-03-04T10:52:42Z
date_updated: 2024-03-04T10:52:42Z
file_id: '15065'
file_name: 2020_JourApplCompTopology_Bauer.pdf
file_size: 851190
relation: main_file
success: 1
file_date_updated: 2024-03-04T10:52:42Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '4'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 455-480
publication: Journal of Applied and Computational Topology
publication_identifier:
eissn:
- 2367-1734
issn:
- 2367-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Čech-Delaunay gradient flow and homology inference for self-maps
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2020'
...
---
_id: '15063'
abstract:
- lang: eng
text: We consider the least singular value of a large random matrix with real or
complex i.i.d. Gaussian entries shifted by a constant z∈C. We prove an optimal
lower tail estimate on this singular value in the critical regime where z is around
the spectral edge, thus improving the classical bound of Sankar, Spielman and
Teng (SIAM J. Matrix Anal. Appl. 28:2 (2006), 446–476) for the particular shift-perturbation
in the edge regime. Lacking Brézin–Hikami formulas in the real case, we rely on
the superbosonization formula (Comm. Math. Phys. 283:2 (2008), 343–395).
acknowledgement: Partially supported by ERC Advanced Grant No. 338804. This project
has received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Sklodowska-Curie Grant Agreement No. 66538
article_processing_charge: No
article_type: original
author:
- first_name: Giorgio
full_name: Cipolloni, Giorgio
id: 42198EFA-F248-11E8-B48F-1D18A9856A87
last_name: Cipolloni
orcid: 0000-0002-4901-7992
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Dominik J
full_name: Schröder, Dominik J
id: 408ED176-F248-11E8-B48F-1D18A9856A87
last_name: Schröder
orcid: 0000-0002-2904-1856
citation:
ama: Cipolloni G, Erdös L, Schröder DJ. Optimal lower bound on the least singular
value of the shifted Ginibre ensemble. Probability and Mathematical Physics.
2020;1(1):101-146. doi:10.2140/pmp.2020.1.101
apa: Cipolloni, G., Erdös, L., & Schröder, D. J. (2020). Optimal lower bound
on the least singular value of the shifted Ginibre ensemble. Probability and
Mathematical Physics. Mathematical Sciences Publishers. https://doi.org/10.2140/pmp.2020.1.101
chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Optimal Lower
Bound on the Least Singular Value of the Shifted Ginibre Ensemble.” Probability
and Mathematical Physics. Mathematical Sciences Publishers, 2020. https://doi.org/10.2140/pmp.2020.1.101.
ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “Optimal lower bound on the least
singular value of the shifted Ginibre ensemble,” Probability and Mathematical
Physics, vol. 1, no. 1. Mathematical Sciences Publishers, pp. 101–146, 2020.
ista: Cipolloni G, Erdös L, Schröder DJ. 2020. Optimal lower bound on the least
singular value of the shifted Ginibre ensemble. Probability and Mathematical Physics.
1(1), 101–146.
mla: Cipolloni, Giorgio, et al. “Optimal Lower Bound on the Least Singular Value
of the Shifted Ginibre Ensemble.” Probability and Mathematical Physics,
vol. 1, no. 1, Mathematical Sciences Publishers, 2020, pp. 101–46, doi:10.2140/pmp.2020.1.101.
short: G. Cipolloni, L. Erdös, D.J. Schröder, Probability and Mathematical Physics
1 (2020) 101–146.
date_created: 2024-03-04T10:27:57Z
date_published: 2020-11-16T00:00:00Z
date_updated: 2024-03-04T10:33:15Z
day: '16'
department:
- _id: LaEr
doi: 10.2140/pmp.2020.1.101
ec_funded: 1
external_id:
arxiv:
- '1908.01653'
intvolume: ' 1'
issue: '1'
keyword:
- General Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1908.01653
month: '11'
oa: 1
oa_version: Preprint
page: 101-146
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Probability and Mathematical Physics
publication_identifier:
issn:
- 2690-1005
- 2690-0998
publication_status: published
publisher: Mathematical Sciences Publishers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optimal lower bound on the least singular value of the shifted Ginibre ensemble
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2020'
...
---
_id: '15059'
abstract:
- lang: eng
text: "In this paper we present a room temperature radiometer that can eliminate
the need of using cryostats in satellite payload reducing its weight and improving
reliability. The proposed radiometer is based on an electro-optic upconverter
that boosts up microwave photons energy by upconverting them into an optical domain
what makes them immune to thermal noise even if operating at room temperature.
The converter uses a high-quality factor whispering gallery\r\nmode (WGM) resonator
providing naturally narrow bandwidth and therefore might be useful for applications
like microwave hyperspectral sensing. The upconversion process is explained by\r\nproviding
essential information about photon conversion efficiency and sensitivity. To prove
the concept, we describe an experiment which shows state-of-the-art photon conversion
efficiency n=10-5 per mW of pump power at the frequency of 80 GHz."
acknowledgement: This work has been financially supported by Comunidad de Madrid S2018/NMT-4333
ARTINLARA-CM projects, and “FUNDACIÓN SENER” REFTA projects.
article_processing_charge: No
author:
- first_name: Michal
full_name: Wasiak, Michal
last_name: Wasiak
- first_name: Gabriel Santamaria
full_name: Botello, Gabriel Santamaria
last_name: Botello
- first_name: Kerlos Atia
full_name: Abdalmalak, Kerlos Atia
last_name: Abdalmalak
- first_name: Florian
full_name: Sedlmeir, Florian
last_name: Sedlmeir
- first_name: Alfredo R
full_name: Rueda Sanchez, Alfredo R
id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
last_name: Rueda Sanchez
orcid: 0000-0001-6249-5860
- first_name: Daniel
full_name: Segovia-Vargas, Daniel
last_name: Segovia-Vargas
- first_name: Harald G. L.
full_name: Schwefel, Harald G. L.
last_name: Schwefel
- first_name: Luis Enrique Garcia
full_name: Munoz, Luis Enrique Garcia
last_name: Munoz
citation:
ama: 'Wasiak M, Botello GS, Abdalmalak KA, et al. Compact millimeter and submillimeter-wave
photonic radiometer for cubesats. In: 14th European Conference on Antennas
and Propagation. IEEE; 2020. doi:10.23919/eucap48036.2020.9135962'
apa: 'Wasiak, M., Botello, G. S., Abdalmalak, K. A., Sedlmeir, F., Rueda Sanchez,
A. R., Segovia-Vargas, D., … Munoz, L. E. G. (2020). Compact millimeter and submillimeter-wave
photonic radiometer for cubesats. In 14th European Conference on Antennas and
Propagation. Copenhagen, Denmark: IEEE. https://doi.org/10.23919/eucap48036.2020.9135962'
chicago: Wasiak, Michal, Gabriel Santamaria Botello, Kerlos Atia Abdalmalak, Florian
Sedlmeir, Alfredo R Rueda Sanchez, Daniel Segovia-Vargas, Harald G. L. Schwefel,
and Luis Enrique Garcia Munoz. “Compact Millimeter and Submillimeter-Wave Photonic
Radiometer for Cubesats.” In 14th European Conference on Antennas and Propagation.
IEEE, 2020. https://doi.org/10.23919/eucap48036.2020.9135962.
ieee: M. Wasiak et al., “Compact millimeter and submillimeter-wave photonic
radiometer for cubesats,” in 14th European Conference on Antennas and Propagation,
Copenhagen, Denmark, 2020.
ista: 'Wasiak M, Botello GS, Abdalmalak KA, Sedlmeir F, Rueda Sanchez AR, Segovia-Vargas
D, Schwefel HGL, Munoz LEG. 2020. Compact millimeter and submillimeter-wave photonic
radiometer for cubesats. 14th European Conference on Antennas and Propagation.
EuCAP: European Conference on Antennas and Propagation.'
mla: Wasiak, Michal, et al. “Compact Millimeter and Submillimeter-Wave Photonic
Radiometer for Cubesats.” 14th European Conference on Antennas and Propagation,
IEEE, 2020, doi:10.23919/eucap48036.2020.9135962.
short: M. Wasiak, G.S. Botello, K.A. Abdalmalak, F. Sedlmeir, A.R. Rueda Sanchez,
D. Segovia-Vargas, H.G.L. Schwefel, L.E.G. Munoz, in:, 14th European Conference
on Antennas and Propagation, IEEE, 2020.
conference:
end_date: 2020-03-20
location: Copenhagen, Denmark
name: 'EuCAP: European Conference on Antennas and Propagation'
start_date: 2020-03-15
date_created: 2024-03-04T09:57:48Z
date_published: 2020-07-08T00:00:00Z
date_updated: 2024-03-04T10:02:49Z
day: '08'
department:
- _id: JoFi
doi: 10.23919/eucap48036.2020.9135962
language:
- iso: eng
month: '07'
oa_version: None
publication: 14th European Conference on Antennas and Propagation
publication_identifier:
eisbn:
- '9788831299008'
publication_status: published
publisher: IEEE
quality_controlled: '1'
status: public
title: Compact millimeter and submillimeter-wave photonic radiometer for cubesats
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '15074'
abstract:
- lang: eng
text: We introduce a new graph problem, the token dropping game, and we show how
to solve it efficiently in a distributed setting. We use the token dropping game
as a tool to design an efficient distributed algorithm for the stable orientation
problem, which is a special case of the more general locally optimal semi-matching
problem. The prior work by Czygrinow et al. (DISC 2012) finds a locally optimal
semi-matching in O(Δ⁵) rounds in graphs of maximum degree Δ, which directly implies
an algorithm with the same runtime for stable orientations. We improve the runtime
to O(Δ⁴) for stable orientations and prove a lower bound of Ω(Δ) rounds.
alternative_title:
- LIPIcs
article_number: '40'
article_processing_charge: No
author:
- first_name: Sebastian
full_name: Brandt, Sebastian
last_name: Brandt
- first_name: Barbara
full_name: Keller, Barbara
last_name: Keller
- first_name: Joel
full_name: Rybicki, Joel
id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
last_name: Rybicki
orcid: 0000-0002-6432-6646
- first_name: Jukka
full_name: Suomela, Jukka
last_name: Suomela
- first_name: Jara
full_name: Uitto, Jara
last_name: Uitto
citation:
ama: 'Brandt S, Keller B, Rybicki J, Suomela J, Uitto J. Brief announcement: Efficient
load-balancing through distributed token dropping. In: 34th International Symposium
on Distributed Computing. Vol 179. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik; 2020. doi:10.4230/LIPIcs.DISC.2020.40'
apa: 'Brandt, S., Keller, B., Rybicki, J., Suomela, J., & Uitto, J. (2020).
Brief announcement: Efficient load-balancing through distributed token dropping.
In 34th International Symposium on Distributed Computing (Vol. 179). Virtual:
Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.DISC.2020.40'
chicago: 'Brandt, Sebastian, Barbara Keller, Joel Rybicki, Jukka Suomela, and Jara
Uitto. “Brief Announcement: Efficient Load-Balancing through Distributed Token
Dropping.” In 34th International Symposium on Distributed Computing, Vol.
179. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. https://doi.org/10.4230/LIPIcs.DISC.2020.40.'
ieee: 'S. Brandt, B. Keller, J. Rybicki, J. Suomela, and J. Uitto, “Brief announcement:
Efficient load-balancing through distributed token dropping,” in 34th International
Symposium on Distributed Computing, Virtual, 2020, vol. 179.'
ista: 'Brandt S, Keller B, Rybicki J, Suomela J, Uitto J. 2020. Brief announcement:
Efficient load-balancing through distributed token dropping. 34th International
Symposium on Distributed Computing. DISC: Symposium on Distributed Computing,
LIPIcs, vol. 179, 40.'
mla: 'Brandt, Sebastian, et al. “Brief Announcement: Efficient Load-Balancing through
Distributed Token Dropping.” 34th International Symposium on Distributed Computing,
vol. 179, 40, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020, doi:10.4230/LIPIcs.DISC.2020.40.'
short: S. Brandt, B. Keller, J. Rybicki, J. Suomela, J. Uitto, in:, 34th International
Symposium on Distributed Computing, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2020.
conference:
end_date: 2020-10-16
location: Virtual
name: 'DISC: Symposium on Distributed Computing'
start_date: 2020-10-12
date_created: 2024-03-05T07:09:12Z
date_published: 2020-10-07T00:00:00Z
date_updated: 2024-03-05T07:13:13Z
day: '07'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.4230/LIPIcs.DISC.2020.40
external_id:
arxiv:
- '2005.07761'
file:
- access_level: open_access
checksum: 23e2d9321aef53092dc1e24a8ab82d72
content_type: application/pdf
creator: dernst
date_created: 2024-03-05T07:08:27Z
date_updated: 2024-03-05T07:08:27Z
file_id: '15075'
file_name: 2020_LIPIcs_Brandt.pdf
file_size: 303529
relation: main_file
success: 1
file_date_updated: 2024-03-05T07:08:27Z
has_accepted_license: '1'
intvolume: ' 179'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/3.0/
month: '10'
oa: 1
oa_version: Published Version
publication: 34th International Symposium on Distributed Computing
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
related_material:
record:
- id: '9678'
relation: later_version
status: public
scopus_import: '1'
status: public
title: 'Brief announcement: Efficient load-balancing through distributed token dropping'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
short: CC BY (3.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 179
year: '2020'
...
---
_id: '15077'
abstract:
- lang: eng
text: "We consider the following dynamic load-balancing process: given an underlying
graph G with n nodes, in each step t≥ 0, one unit of load is created, and placed
at a randomly chosen graph node. In the same step, the chosen node picks a random
neighbor, and the two nodes balance their loads by averaging them. We are interested
in the expected gap between the minimum and maximum loads at nodes as the process
progresses, and its dependence on n and on the graph structure. Variants of the
above graphical balanced allocation process have been studied previously by Peres,
Talwar, and Wieder [Peres et al., 2015], and by Sauerwald and Sun [Sauerwald and
Sun, 2015]. These authors left as open the question of characterizing the gap
in the case of cycle graphs in the dynamic case, where weights are created during
the algorithm’s execution. For this case, the only known upper bound is of \U0001D4AA(n
log n), following from a majorization argument due to [Peres et al., 2015], which
analyzes a related graphical allocation process. In this paper, we provide an
upper bound of \U0001D4AA (√n log n) on the expected gap of the above process
for cycles of length n. We introduce a new potential analysis technique, which
enables us to bound the difference in load between k-hop neighbors on the cycle,
for any k ≤ n/2. We complement this with a \"gap covering\" argument, which bounds
the maximum value of the gap by bounding its value across all possible subsets
of a certain structure, and recursively bounding the gaps within each subset.
We provide analytical and experimental evidence that our upper bound on the gap
is tight up to a logarithmic factor."
acknowledgement: "The authors sincerely thank Thomas Sauerwald and George Giakkoupis
for insightful discussions, and Mohsen Ghaffari, Yuval Peres, and Udi Wieder for
feedback on earlier\r\nversions of this draft. We also thank the ICALP anonymous
reviewers for their very useful comments.\r\nFunding: European Research Council
funding award PR1042ERC01"
alternative_title:
- LIPIcs
article_number: '7'
article_processing_charge: No
author:
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Giorgi
full_name: Nadiradze, Giorgi
id: 3279A00C-F248-11E8-B48F-1D18A9856A87
last_name: Nadiradze
orcid: 0000-0001-5634-0731
- first_name: Amirmojtaba
full_name: Sabour, Amirmojtaba
id: bcc145fd-e77f-11ea-ae8b-80d661dbff67
last_name: Sabour
citation:
ama: 'Alistarh D-A, Nadiradze G, Sabour A. Dynamic averaging load balancing on cycles.
In: 47th International Colloquium on Automata, Languages, and Programming.
Vol 168. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2020. doi:10.4230/LIPIcs.ICALP.2020.7'
apa: 'Alistarh, D.-A., Nadiradze, G., & Sabour, A. (2020). Dynamic averaging
load balancing on cycles. In 47th International Colloquium on Automata, Languages,
and Programming (Vol. 168). Saarbrücken, Germany, Virtual: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.ICALP.2020.7'
chicago: Alistarh, Dan-Adrian, Giorgi Nadiradze, and Amirmojtaba Sabour. “Dynamic
Averaging Load Balancing on Cycles.” In 47th International Colloquium on Automata,
Languages, and Programming, Vol. 168. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, 2020. https://doi.org/10.4230/LIPIcs.ICALP.2020.7.
ieee: D.-A. Alistarh, G. Nadiradze, and A. Sabour, “Dynamic averaging load balancing
on cycles,” in 47th International Colloquium on Automata, Languages, and Programming,
Saarbrücken, Germany, Virtual, 2020, vol. 168.
ista: 'Alistarh D-A, Nadiradze G, Sabour A. 2020. Dynamic averaging load balancing
on cycles. 47th International Colloquium on Automata, Languages, and Programming.
ICALP: International Colloquium on Automata, Languages, and Programming, LIPIcs,
vol. 168, 7.'
mla: Alistarh, Dan-Adrian, et al. “Dynamic Averaging Load Balancing on Cycles.”
47th International Colloquium on Automata, Languages, and Programming,
vol. 168, 7, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020, doi:10.4230/LIPIcs.ICALP.2020.7.
short: D.-A. Alistarh, G. Nadiradze, A. Sabour, in:, 47th International Colloquium
on Automata, Languages, and Programming, Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, 2020.
conference:
end_date: 2020-07-11
location: Saarbrücken, Germany, Virtual
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 2020-07-08
date_created: 2024-03-05T07:25:37Z
date_published: 2020-06-29T00:00:00Z
date_updated: 2024-03-05T07:35:53Z
day: '29'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.4230/LIPIcs.ICALP.2020.7
ec_funded: 1
external_id:
arxiv:
- '2003.09297'
file:
- access_level: open_access
checksum: e5eb16199f4ccfd77a321977eb3f026f
content_type: application/pdf
creator: dernst
date_created: 2024-03-05T07:25:15Z
date_updated: 2024-03-05T07:25:15Z
file_id: '15078'
file_name: 2020_LIPIcs_Alistarh.pdf
file_size: 782987
relation: main_file
success: 1
file_date_updated: 2024-03-05T07:25:15Z
has_accepted_license: '1'
intvolume: ' 168'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: 47th International Colloquium on Automata, Languages, and Programming
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
related_material:
record:
- id: '8286'
relation: later_version
status: public
scopus_import: '1'
status: public
title: Dynamic averaging load balancing on cycles
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
short: CC BY (3.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 168
year: '2020'
...
---
_id: '15082'
abstract:
- lang: eng
text: "Two plane drawings of geometric graphs on the same set of points are called
disjoint compatible if their union is plane and they do not have an edge in common.
For a given set S of 2n points two plane drawings of perfect matchings M1 and
M2 (which do not need to be disjoint nor compatible) are disjoint tree-compatible
if there exists a plane drawing of a spanning tree T on S which is disjoint compatible
to both M1 and M2.\r\nWe show that the graph of all disjoint tree-compatible perfect
geometric matchings on 2n points in convex position is connected if and only if
2n ≥ 10. Moreover, in that case the diameter\r\nof this graph is either 4 or 5,
independent of n."
acknowledgement: Research on this work was initiated at the 6th Austrian-Japanese-Mexican-Spanish
Workshop on Discrete Geometry and continued during the 16th European Geometric Graph-Week,
both held near Strobl, Austria. We are grateful to the participants for the inspiring
atmosphere. We especially thank Alexander Pilz for bringing this class of problems
to our attention and Birgit Vogtenhuber for inspiring discussions. D.P. is partially
supported by the FWF grant I 3340-N35 (Collaborative DACH project Arrangements and
Drawings). The research stay of P.P. at IST Austria is funded by the project CZ.02.2.69/0.0/0.0/17_050/0008466
Improvement of internationalization in the field of research and development at
Charles University, through the support of quality projects MSCA-IF. This project
has received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie grant agreement No 734922.
article_number: '56'
article_processing_charge: No
author:
- first_name: Oswin
full_name: Aichholzer, Oswin
last_name: Aichholzer
- first_name: Julia
full_name: Obmann, Julia
last_name: Obmann
- first_name: Pavel
full_name: Patak, Pavel
id: B593B804-1035-11EA-B4F1-947645A5BB83
last_name: Patak
- first_name: Daniel
full_name: Perz, Daniel
last_name: Perz
- first_name: Josef
full_name: Tkadlec, Josef
id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
last_name: Tkadlec
orcid: 0000-0002-1097-9684
citation:
ama: 'Aichholzer O, Obmann J, Patak P, Perz D, Tkadlec J. Disjoint tree-compatible
plane perfect matchings. In: 36th European Workshop on Computational Geometry.
; 2020.'
apa: Aichholzer, O., Obmann, J., Patak, P., Perz, D., & Tkadlec, J. (2020).
Disjoint tree-compatible plane perfect matchings. In 36th European Workshop
on Computational Geometry. Würzburg, Germany, Virtual.
chicago: Aichholzer, Oswin, Julia Obmann, Pavel Patak, Daniel Perz, and Josef Tkadlec.
“Disjoint Tree-Compatible Plane Perfect Matchings.” In 36th European Workshop
on Computational Geometry, 2020.
ieee: O. Aichholzer, J. Obmann, P. Patak, D. Perz, and J. Tkadlec, “Disjoint tree-compatible
plane perfect matchings,” in 36th European Workshop on Computational Geometry,
Würzburg, Germany, Virtual, 2020.
ista: 'Aichholzer O, Obmann J, Patak P, Perz D, Tkadlec J. 2020. Disjoint tree-compatible
plane perfect matchings. 36th European Workshop on Computational Geometry. EuroCG:
European Workshop on Computational Geometry, 56.'
mla: Aichholzer, Oswin, et al. “Disjoint Tree-Compatible Plane Perfect Matchings.”
36th European Workshop on Computational Geometry, 56, 2020.
short: O. Aichholzer, J. Obmann, P. Patak, D. Perz, J. Tkadlec, in:, 36th European
Workshop on Computational Geometry, 2020.
conference:
end_date: 2020-03-18
location: Würzburg, Germany, Virtual
name: 'EuroCG: European Workshop on Computational Geometry'
start_date: 2020-03-16
date_created: 2024-03-05T08:57:17Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2024-03-05T09:00:07Z
day: '01'
department:
- _id: KrCh
- _id: UlWa
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www1.pub.informatik.uni-wuerzburg.de/eurocg2020/data/uploads/papers/eurocg20_paper_56.pdf
month: '04'
oa: 1
oa_version: Published Version
publication: 36th European Workshop on Computational Geometry
publication_status: published
quality_controlled: '1'
status: public
title: Disjoint tree-compatible plane perfect matchings
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '6748'
abstract:
- lang: eng
text: "Fitting a function by using linear combinations of a large number N of `simple'
components is one of the most fruitful ideas in statistical learning. This idea
lies at the core of a variety of methods, from two-layer neural networks to kernel
regression, to boosting. In general, the resulting risk minimization problem is
non-convex and is solved by gradient descent or its variants. Unfortunately, little
is known about global convergence properties of these approaches.\r\nHere we consider
the problem of learning a concave function f on a compact convex domain Ω⊆ℝd,
using linear combinations of `bump-like' components (neurons). The parameters
to be fitted are the centers of N bumps, and the resulting empirical risk minimization
problem is highly non-convex. We prove that, in the limit in which the number
of neurons diverges, the evolution of gradient descent converges to a Wasserstein
gradient flow in the space of probability distributions over Ω. Further, when
the bump width δ tends to 0, this gradient flow has a limit which is a viscous
porous medium equation. Remarkably, the cost function optimized by this gradient
flow exhibits a special property known as displacement convexity, which implies
exponential convergence rates for N→∞, δ→0. Surprisingly, this asymptotic theory
appears to capture well the behavior for moderate values of δ,N. Explaining this
phenomenon, and understanding the dependence on δ,N in a quantitative manner remains
an outstanding challenge."
article_processing_charge: No
article_type: original
author:
- first_name: Adel
full_name: Javanmard, Adel
last_name: Javanmard
- first_name: Marco
full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
- first_name: Andrea
full_name: Montanari, Andrea
last_name: Montanari
citation:
ama: Javanmard A, Mondelli M, Montanari A. Analysis of a two-layer neural network
via displacement convexity. Annals of Statistics. 2020;48(6):3619-3642.
doi:10.1214/20-AOS1945
apa: Javanmard, A., Mondelli, M., & Montanari, A. (2020). Analysis of a two-layer
neural network via displacement convexity. Annals of Statistics. Institute
of Mathematical Statistics. https://doi.org/10.1214/20-AOS1945
chicago: Javanmard, Adel, Marco Mondelli, and Andrea Montanari. “Analysis of a Two-Layer
Neural Network via Displacement Convexity.” Annals of Statistics. Institute
of Mathematical Statistics, 2020. https://doi.org/10.1214/20-AOS1945.
ieee: A. Javanmard, M. Mondelli, and A. Montanari, “Analysis of a two-layer neural
network via displacement convexity,” Annals of Statistics, vol. 48, no.
6. Institute of Mathematical Statistics, pp. 3619–3642, 2020.
ista: Javanmard A, Mondelli M, Montanari A. 2020. Analysis of a two-layer neural
network via displacement convexity. Annals of Statistics. 48(6), 3619–3642.
mla: Javanmard, Adel, et al. “Analysis of a Two-Layer Neural Network via Displacement
Convexity.” Annals of Statistics, vol. 48, no. 6, Institute of Mathematical
Statistics, 2020, pp. 3619–42, doi:10.1214/20-AOS1945.
short: A. Javanmard, M. Mondelli, A. Montanari, Annals of Statistics 48 (2020) 3619–3642.
date_created: 2019-07-31T09:39:42Z
date_published: 2020-12-11T00:00:00Z
date_updated: 2024-03-06T08:28:50Z
day: '11'
department:
- _id: MaMo
doi: 10.1214/20-AOS1945
external_id:
arxiv:
- '1901.01375'
isi:
- '000598369200021'
intvolume: ' 48'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1901.01375
month: '12'
oa: 1
oa_version: Preprint
page: 3619-3642
publication: Annals of Statistics
publication_identifier:
eissn:
- 1941-7330
issn:
- 1932-6157
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
status: public
title: Analysis of a two-layer neural network via displacement convexity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2020'
...
---
_id: '15070'
abstract:
- lang: eng
text: This workshop focused on interactions between the various perspectives on
the moduli space of Higgs bundles over a Riemann surface. This subject draws on
algebraic geometry, geometric topology, geometric analysis and mathematical physics,
and the goal was to promote interactions between these various branches of the
subject. The main current directions of research were well represented by the
participants, and the talks included many from both senior and junior participants.
article_processing_charge: No
article_type: original
author:
- first_name: Lara
full_name: Anderson, Lara
last_name: Anderson
- first_name: Tamás
full_name: Hausel, Tamás
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Rafe
full_name: Mazzeo, Rafe
last_name: Mazzeo
- first_name: Laura
full_name: Schaposnik, Laura
last_name: Schaposnik
citation:
ama: Anderson L, Hausel T, Mazzeo R, Schaposnik L. Geometry and physics of Higgs
bundles. Oberwolfach Reports. 2020;16(2):1357-1417. doi:10.4171/owr/2019/23
apa: Anderson, L., Hausel, T., Mazzeo, R., & Schaposnik, L. (2020). Geometry
and physics of Higgs bundles. Oberwolfach Reports. European Mathematical
Society. https://doi.org/10.4171/owr/2019/23
chicago: Anderson, Lara, Tamás Hausel, Rafe Mazzeo, and Laura Schaposnik. “Geometry
and Physics of Higgs Bundles.” Oberwolfach Reports. European Mathematical
Society, 2020. https://doi.org/10.4171/owr/2019/23.
ieee: L. Anderson, T. Hausel, R. Mazzeo, and L. Schaposnik, “Geometry and physics
of Higgs bundles,” Oberwolfach Reports, vol. 16, no. 2. European Mathematical
Society, pp. 1357–1417, 2020.
ista: Anderson L, Hausel T, Mazzeo R, Schaposnik L. 2020. Geometry and physics of
Higgs bundles. Oberwolfach Reports. 16(2), 1357–1417.
mla: Anderson, Lara, et al. “Geometry and Physics of Higgs Bundles.” Oberwolfach
Reports, vol. 16, no. 2, European Mathematical Society, 2020, pp. 1357–417,
doi:10.4171/owr/2019/23.
short: L. Anderson, T. Hausel, R. Mazzeo, L. Schaposnik, Oberwolfach Reports 16
(2020) 1357–1417.
date_created: 2024-03-04T11:36:31Z
date_published: 2020-06-04T00:00:00Z
date_updated: 2024-03-11T09:20:34Z
day: '04'
department:
- _id: TaHa
doi: 10.4171/owr/2019/23
intvolume: ' 16'
issue: '2'
keyword:
- Organic Chemistry
- Biochemistry
language:
- iso: eng
month: '06'
oa_version: None
page: 1357-1417
publication: Oberwolfach Reports
publication_identifier:
issn:
- 1660-8933
publication_status: published
publisher: European Mathematical Society
quality_controlled: '1'
status: public
title: Geometry and physics of Higgs bundles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2020'
...
---
_id: '8741'
abstract:
- lang: eng
text: "In ecology, climate and other fields, (sub)systems have been identified that
can transition into a qualitatively different state when a critical threshold
or tipping point in a driving process is crossed. An understanding of those tipping
elements is of great interest given the increasing influence of humans on the
biophysical Earth system. Complex interactions exist between tipping elements,
e.g. physical mechanisms connect subsystems of the climate system. Based on earlier
work on such coupled nonlinear systems, we systematically assessed the qualitative
long-term behaviour of interacting tipping elements. We developed an understanding
of the consequences of interactions\r\non the tipping behaviour allowing for tipping
cascades to emerge under certain conditions. The (narrative) application of\r\nthese
qualitative results to real-world examples of interacting tipping elements indicates
that tipping cascades with profound consequences may occur: the interacting Greenland
ice sheet and thermohaline ocean circulation might tip before the tipping points
of the isolated subsystems are crossed. The eutrophication of the first lake in
a lake chain might propagate through the following lakes without a crossing of
their individual critical nutrient input levels. The possibility of emerging cascading
tipping dynamics calls for the development of a unified theory of interacting
tipping elements and the quantitative analysis of interacting real-world tipping
elements."
acknowledgement: "V.K. thanks the German National Academic Foundation (Studienstiftung
des deutschen Volkes) for financial\r\nsupport. J.F.D. is grateful for financial
support by the Stordalen Foundation via the Planetary Boundary Research\r\nNetwork
(PB.net), the Earth League’s EarthDoc program and the European Research Council
Advanced Grant\r\nproject ERA (Earth Resilience in the Anthropocene). We are thankful
for support by the Leibniz Association\r\n(project DominoES).\r\nAcknowledgements.
This work has been performed in the context of the copan collaboration and the FutureLab
on Earth\r\nResilience in the Anthropocene at the Potsdam Institute for Climate
Impact Research. Furthermore, we acknowledge\r\ndiscussions with and helpful comments
by N. Wunderling, J. Heitzig and M. Wiedermann."
article_number: '200599'
article_processing_charge: No
article_type: original
author:
- first_name: Ann Kristin
full_name: Klose, Ann Kristin
last_name: Klose
- first_name: Volker
full_name: Karle, Volker
id: D7C012AE-D7ED-11E9-95E8-1EC5E5697425
last_name: Karle
orcid: 0000-0002-6963-0129
- first_name: Ricarda
full_name: Winkelmann, Ricarda
last_name: Winkelmann
- first_name: Jonathan F.
full_name: Donges, Jonathan F.
last_name: Donges
citation:
ama: 'Klose AK, Karle V, Winkelmann R, Donges JF. Emergence of cascading dynamics
in interacting tipping elements of ecology and climate: Cascading dynamics in
tipping elements. Royal Society Open Science. 2020;7(6). doi:10.1098/rsos.200599'
apa: 'Klose, A. K., Karle, V., Winkelmann, R., & Donges, J. F. (2020). Emergence
of cascading dynamics in interacting tipping elements of ecology and climate:
Cascading dynamics in tipping elements. Royal Society Open Science. The
Royal Society. https://doi.org/10.1098/rsos.200599'
chicago: 'Klose, Ann Kristin, Volker Karle, Ricarda Winkelmann, and Jonathan F.
Donges. “Emergence of Cascading Dynamics in Interacting Tipping Elements of Ecology
and Climate: Cascading Dynamics in Tipping Elements.” Royal Society Open Science.
The Royal Society, 2020. https://doi.org/10.1098/rsos.200599.'
ieee: 'A. K. Klose, V. Karle, R. Winkelmann, and J. F. Donges, “Emergence of cascading
dynamics in interacting tipping elements of ecology and climate: Cascading dynamics
in tipping elements,” Royal Society Open Science, vol. 7, no. 6. The Royal
Society, 2020.'
ista: 'Klose AK, Karle V, Winkelmann R, Donges JF. 2020. Emergence of cascading
dynamics in interacting tipping elements of ecology and climate: Cascading dynamics
in tipping elements. Royal Society Open Science. 7(6), 200599.'
mla: 'Klose, Ann Kristin, et al. “Emergence of Cascading Dynamics in Interacting
Tipping Elements of Ecology and Climate: Cascading Dynamics in Tipping Elements.”
Royal Society Open Science, vol. 7, no. 6, 200599, The Royal Society, 2020,
doi:10.1098/rsos.200599.'
short: A.K. Klose, V. Karle, R. Winkelmann, J.F. Donges, Royal Society Open Science
7 (2020).
date_created: 2020-11-08T23:01:25Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2024-03-12T12:31:30Z
day: '01'
ddc:
- '530'
- '550'
department:
- _id: MiLe
doi: 10.1098/rsos.200599
external_id:
arxiv:
- '1910.12042'
isi:
- '000545625200001'
file:
- access_level: open_access
checksum: 5505c445de373bfd836eb4d3b48b1f37
content_type: application/pdf
creator: dernst
date_created: 2020-11-09T09:07:11Z
date_updated: 2020-11-09T09:07:11Z
file_id: '8748'
file_name: 2020_RoyalSocOpenScience_Klose.pdf
file_size: 1611485
relation: main_file
success: 1
file_date_updated: 2020-11-09T09:07:11Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Royal Society Open Science
publication_identifier:
eissn:
- '20545703'
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Emergence of cascading dynamics in interacting tipping elements of ecology
and climate: Cascading dynamics in tipping elements'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2020'
...
---
_id: '7687'
abstract:
- lang: eng
text: A working group, which was established within the Network of Repository Managers (RepManNet), has dealt with common certifications for repositories. In
addition, current requirements of the research funding agencies FWF and EU were
also taken into account. The Core Trust Seal was examined in more detail. For
this purpose, a questionnaire was sent to those organizations that are already certified
with CTS in Austria. The answers were summarized and evaluated anonymously. It
is recommended to go for a repository certification. Moreover, the development
of a DINI certificate in Austria is strongly suggested.
- lang: ger
text: ' Eine Arbeitsgruppe, die im Rahmen des Netzwerks für RepositorienmanagerInnen
(RepManNet) entstanden ist, hat sich mit gängigen Zertifizierungen für Repositorien
beschäftigt. Weiters wurden aktuelle Vorgaben der Forschungsförderer FWF und EU
herangezogen. Das Core Trust Seal wurde genauer betrachtet. Hierfür wurden jenen Organisationen, die in Österreich bereits mit CTS zertifiziert
sind, ein Fragebogen übermittelt. Die Antworten wurden anonymisiert zusammengefasst
und ausgewertet. Plädiert wird für eine Zertifizierung von Repositorien und die
Entwicklung einer DINI-Zertifizierung in Österreich.'
article_processing_charge: No
article_type: original
author:
- first_name: Doris
full_name: Ernst, Doris
id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
last_name: Ernst
orcid: 0000-0002-2354-0195
- first_name: Gertraud
full_name: Novotny, Gertraud
last_name: Novotny
- first_name: Eva Maria
full_name: Schönher, Eva Maria
last_name: Schönher
citation:
ama: Ernst D, Novotny G, Schönher EM. (Core Trust) Seal your repository! Mitteilungen
der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare. 2020;73(1):46-59.
doi:10.31263/voebm.v73i1.3491
apa: Ernst, D., Novotny, G., & Schönher, E. M. (2020). (Core Trust) Seal your
repository! Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen
und Bibliothekare. Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare.
https://doi.org/10.31263/voebm.v73i1.3491
chicago: Ernst, Doris, Gertraud Novotny, and Eva Maria Schönher. “(Core Trust) Seal
your repository!” Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen
und Bibliothekare. Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare,
2020. https://doi.org/10.31263/voebm.v73i1.3491.
ieee: D. Ernst, G. Novotny, and E. M. Schönher, “(Core Trust) Seal your repository!,”
Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare,
vol. 73, no. 1. Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare,
pp. 46–59, 2020.
ista: Ernst D, Novotny G, Schönher EM. 2020. (Core Trust) Seal your repository!
Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare.
73(1), 46–59.
mla: Ernst, Doris, et al. “(Core Trust) Seal your repository!” Mitteilungen der
Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, vol. 73,
no. 1, Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare, 2020,
pp. 46–59, doi:10.31263/voebm.v73i1.3491.
short: D. Ernst, G. Novotny, E.M. Schönher, Mitteilungen der Vereinigung Österreichischer
Bibliothekarinnen und Bibliothekare 73 (2020) 46–59.
date_created: 2020-04-28T08:37:38Z
date_published: 2020-04-28T00:00:00Z
date_updated: 2024-03-12T10:12:33Z
day: '28'
ddc:
- '020'
department:
- _id: E-Lib
doi: 10.31263/voebm.v73i1.3491
file:
- access_level: open_access
checksum: fee784f15a489deb7def6ccf8c5bf8c3
content_type: application/pdf
creator: dernst
date_created: 2020-06-17T10:50:13Z
date_updated: 2024-03-12T10:12:33Z
file_id: '7970'
file_name: 2020_VOEB_Ernst.pdf
file_size: 579291
relation: main_file
file_date_updated: 2024-03-12T10:12:33Z
has_accepted_license: '1'
intvolume: ' 73'
issue: '1'
language:
- iso: ger
month: '04'
oa: 1
oa_version: Published Version
page: 46-59
popular_science: '1'
publication: Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare
publication_identifier:
issn:
- 1022-2588
publication_status: published
publisher: Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare
scopus_import: '1'
status: public
title: (Core Trust) Seal your repository!
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 73
year: '2020'
...
---
_id: '15079'
abstract:
- lang: eng
text: "Large complex systems tend to develop universal patterns that often represent
their essential characteristics. For example, the cumulative effects of independent
or weakly dependent random variables often yield the Gaussian universality class
via the central limit theorem. For non-commutative random variables, e.g. matrices,
the Gaussian behavior is often replaced by another universality class, commonly
called random matrix statistics. Nearby eigenvalues are strongly correlated, and,
remarkably, their correlation structure is universal, depending only on the symmetry
type of the matrix. Even more surprisingly, this feature is not restricted to
matrices; in fact Eugene Wigner, the pioneer of the field, discovered in the 1950s
that distributions of the gaps between energy levels of complicated quantum systems
universally follow the same random matrix statistics. This claim has never been
rigorously proved for any realistic physical system but experimental data and
extensive numerics leave no doubt as to its correctness. Since then random matrices
have proved to be extremely useful phenomenological models in a wide range of
applications beyond quantum physics that include number theory, statistics, neuroscience,
population dynamics, wireless communication and mathematical finance. The ubiquity
of random matrices in natural sciences is still a mystery, but recent years have
witnessed a breakthrough in the mathematical description of the statistical structure
of their spectrum. Random matrices and closely related areas such as log-gases
have become an extremely active research area in probability theory.\r\nThis workshop
brought together outstanding researchers from a variety of mathematical backgrounds
whose areas of research are linked to random matrices. While there are strong
links between their motivations, the techniques used by these researchers span
a large swath of mathematics, ranging from purely algebraic techniques to stochastic
analysis, classical probability theory, operator algebra, supersymmetry, orthogonal
polynomials, etc."
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Friedrich
full_name: Götze, Friedrich
last_name: Götze
- first_name: Alice
full_name: Guionnet, Alice
last_name: Guionnet
citation:
ama: Erdös L, Götze F, Guionnet A. Random matrices. Oberwolfach Reports.
2020;16(4):3459-3527. doi:10.4171/owr/2019/56
apa: Erdös, L., Götze, F., & Guionnet, A. (2020). Random matrices. Oberwolfach
Reports. European Mathematical Society. https://doi.org/10.4171/owr/2019/56
chicago: Erdös, László, Friedrich Götze, and Alice Guionnet. “Random Matrices.”
Oberwolfach Reports. European Mathematical Society, 2020. https://doi.org/10.4171/owr/2019/56.
ieee: L. Erdös, F. Götze, and A. Guionnet, “Random matrices,” Oberwolfach Reports,
vol. 16, no. 4. European Mathematical Society, pp. 3459–3527, 2020.
ista: Erdös L, Götze F, Guionnet A. 2020. Random matrices. Oberwolfach Reports.
16(4), 3459–3527.
mla: Erdös, László, et al. “Random Matrices.” Oberwolfach Reports, vol. 16,
no. 4, European Mathematical Society, 2020, pp. 3459–527, doi:10.4171/owr/2019/56.
short: L. Erdös, F. Götze, A. Guionnet, Oberwolfach Reports 16 (2020) 3459–3527.
date_created: 2024-03-05T07:54:44Z
date_published: 2020-11-19T00:00:00Z
date_updated: 2024-03-12T12:25:18Z
day: '19'
department:
- _id: LaEr
doi: 10.4171/owr/2019/56
intvolume: ' 16'
issue: '4'
language:
- iso: eng
month: '11'
oa_version: None
page: 3459-3527
publication: Oberwolfach Reports
publication_identifier:
issn:
- 1660-8933
publication_status: published
publisher: European Mathematical Society
quality_controlled: '1'
status: public
title: Random matrices
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2020'
...
---
_id: '15072'
abstract:
- lang: eng
text: The interaction among fundamental particles in nature leads to many interesting
effects in quantum statistical mechanics; examples include superconductivity for
charged systems and superfluidity in cold gases. It is a huge challenge for mathematical
physics to understand the collective behavior of systems containing a large number
of particles, emerging from known microscopic interactions. In this workshop we
brought together researchers working on different aspects of many-body quantum
mechanics to discuss recent developments, exchange ideas and propose new challenges
and research directions.
article_processing_charge: No
article_type: original
author:
- first_name: Christian
full_name: Hainzl, Christian
last_name: Hainzl
- first_name: Benjamin
full_name: Schlein, Benjamin
last_name: Schlein
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Simone
full_name: Warzel, Simone
last_name: Warzel
citation:
ama: Hainzl C, Schlein B, Seiringer R, Warzel S. Many-body quantum systems. Oberwolfach
Reports. 2020;16(3):2541-2603. doi:10.4171/owr/2019/41
apa: Hainzl, C., Schlein, B., Seiringer, R., & Warzel, S. (2020). Many-body
quantum systems. Oberwolfach Reports. European Mathematical Society. https://doi.org/10.4171/owr/2019/41
chicago: Hainzl, Christian, Benjamin Schlein, Robert Seiringer, and Simone Warzel.
“Many-Body Quantum Systems.” Oberwolfach Reports. European Mathematical
Society, 2020. https://doi.org/10.4171/owr/2019/41.
ieee: C. Hainzl, B. Schlein, R. Seiringer, and S. Warzel, “Many-body quantum systems,”
Oberwolfach Reports, vol. 16, no. 3. European Mathematical Society, pp.
2541–2603, 2020.
ista: Hainzl C, Schlein B, Seiringer R, Warzel S. 2020. Many-body quantum systems.
Oberwolfach Reports. 16(3), 2541–2603.
mla: Hainzl, Christian, et al. “Many-Body Quantum Systems.” Oberwolfach Reports,
vol. 16, no. 3, European Mathematical Society, 2020, pp. 2541–603, doi:10.4171/owr/2019/41.
short: C. Hainzl, B. Schlein, R. Seiringer, S. Warzel, Oberwolfach Reports 16 (2020)
2541–2603.
date_created: 2024-03-04T11:46:12Z
date_published: 2020-09-10T00:00:00Z
date_updated: 2024-03-12T12:02:00Z
day: '10'
department:
- _id: RoSe
doi: 10.4171/owr/2019/41
intvolume: ' 16'
issue: '3'
language:
- iso: eng
month: '09'
oa_version: None
page: 2541-2603
publication: Oberwolfach Reports
publication_identifier:
issn:
- 1660-8933
publication_status: published
publisher: European Mathematical Society
quality_controlled: '1'
status: public
title: Many-body quantum systems
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2020'
...
---
_id: '15071'
abstract:
- lang: eng
text: "A mesophilic methanogenic culture, designated JL01, was isolated from Holocene
permafrost in the Russian Arctic [1]. After long-term extensive cultivation at
15°C it turned out to be a tied binary culture of archaeal (JL01) and bacterial
(Sphaerochaeta associata GLS2) strains.\r\nStrain JL01 was a strict anaerobe and
grew on methanol, acetate and methylamines as energy and carbon sources. Cells
were irregular coccoid, non-motile, non-spore-forming, and Gram-stainpositive.
Optimum conditions for growth were 24-28 oC, pH 6.8–7.3 and 0.075-0.1 M NaCl.\r\nPhylogenetic
tree reconstructions based on 16S rRNA and concatenated alignment of broadly\r\nconserved
protein-coding genes revealed its close relation to Methanosarcina mazei S-6\r\nT
(similarity 99.5%). The comparison of whole genomic sequences (ANI) of the isolate
and the type strain of M.mazei was 98.5%, which is higher than the values recommended
for new species. Thus strain JL01 (=VKM B-2370=JCM 31898) represents the first
M. mazei isolated from permanently subzero Arcticsediments. The long-term co-cultivation
of JL01 with S. associata GLS2T showed the methane production without any additional
carbon and energy sources. Genome analysis of S. associata GLS2T revealed putative
genes involved in methanochondroithin catabolism."
acknowledgement: "The work was supported by of Russian Foundation of Basic Research:
grant № 19-04-00831 for Viktoria Shcherbakova and Olga Troshina, grant № 18-34-00334
for Viktoriia Oshurkova and Vladimir Trubitsyn. \r\nWe thank Dr Natalia Suzina (IBPM
RAS, Federal Research Center Pushchino Center for\r\nBiological Research RAS) for
the help with the microscopic studies, respectively; Dr. Margarita Meyer (Division
of Genetics, Department of Medicine, BWH and HMS, USA) and Dr Fedor Kondrashov (IST,
Austria) for their help in obtaining the genomic sequence of strain JL01. "
article_processing_charge: Yes
author:
- first_name: Viktoriia
full_name: Oshurkova, Viktoriia
last_name: Oshurkova
- first_name: Olga
full_name: Troshina, Olga
last_name: Troshina
- first_name: Vladimir
full_name: Trubitsyn, Vladimir
last_name: Trubitsyn
- first_name: Yana
full_name: Ryzhmanova, Yana
last_name: Ryzhmanova
- first_name: Olga
full_name: Bochkareva, Olga
id: C4558D3C-6102-11E9-A62E-F418E6697425
last_name: Bochkareva
orcid: 0000-0003-1006-6639
- first_name: Viktoria
full_name: Shcherbakova, Viktoria
last_name: Shcherbakova
citation:
ama: 'Oshurkova V, Troshina O, Trubitsyn V, Ryzhmanova Y, Bochkareva O, Shcherbakova
V. Characterization of methanosarcina mazei JL01 isolated from holocene arctic
permafrost and study of the archaeon cooperation with bacterium Sphaerochaeta
associata GLS2T. In: Proceedings of 1st International Electronic Conference
on Microbiology. MDPI; 2020. doi:10.3390/ecm2020-07116'
apa: 'Oshurkova, V., Troshina, O., Trubitsyn, V., Ryzhmanova, Y., Bochkareva, O.,
& Shcherbakova, V. (2020). Characterization of methanosarcina mazei JL01 isolated
from holocene arctic permafrost and study of the archaeon cooperation with bacterium
Sphaerochaeta associata GLS2T. In Proceedings of 1st International Electronic
Conference on Microbiology. Virtual: MDPI. https://doi.org/10.3390/ecm2020-07116'
chicago: Oshurkova, Viktoriia, Olga Troshina, Vladimir Trubitsyn, Yana Ryzhmanova,
Olga Bochkareva, and Viktoria Shcherbakova. “Characterization of Methanosarcina
Mazei JL01 Isolated from Holocene Arctic Permafrost and Study of the Archaeon
Cooperation with Bacterium Sphaerochaeta Associata GLS2T.” In Proceedings of
1st International Electronic Conference on Microbiology. MDPI, 2020. https://doi.org/10.3390/ecm2020-07116.
ieee: V. Oshurkova, O. Troshina, V. Trubitsyn, Y. Ryzhmanova, O. Bochkareva, and
V. Shcherbakova, “Characterization of methanosarcina mazei JL01 isolated from
holocene arctic permafrost and study of the archaeon cooperation with bacterium
Sphaerochaeta associata GLS2T,” in Proceedings of 1st International Electronic
Conference on Microbiology, Virtual, 2020.
ista: 'Oshurkova V, Troshina O, Trubitsyn V, Ryzhmanova Y, Bochkareva O, Shcherbakova
V. 2020. Characterization of methanosarcina mazei JL01 isolated from holocene
arctic permafrost and study of the archaeon cooperation with bacterium Sphaerochaeta
associata GLS2T. Proceedings of 1st International Electronic Conference on Microbiology.
ECM: Electronic Conference on Microbiology.'
mla: Oshurkova, Viktoriia, et al. “Characterization of Methanosarcina Mazei JL01
Isolated from Holocene Arctic Permafrost and Study of the Archaeon Cooperation
with Bacterium Sphaerochaeta Associata GLS2T.” Proceedings of 1st International
Electronic Conference on Microbiology, MDPI, 2020, doi:10.3390/ecm2020-07116.
short: V. Oshurkova, O. Troshina, V. Trubitsyn, Y. Ryzhmanova, O. Bochkareva, V.
Shcherbakova, in:, Proceedings of 1st International Electronic Conference on Microbiology,
MDPI, 2020.
conference:
end_date: 2020-11-30
location: Virtual
name: 'ECM: Electronic Conference on Microbiology'
start_date: 2020-11-02
date_created: 2024-03-04T11:41:31Z
date_published: 2020-11-02T00:00:00Z
date_updated: 2024-03-20T08:06:22Z
day: '02'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.3390/ecm2020-07116
file:
- access_level: open_access
checksum: d1914af7811a21a4b2744eb51b5834e3
content_type: application/pdf
creator: dernst
date_created: 2024-03-20T08:05:46Z
date_updated: 2024-03-20T08:05:46Z
file_id: '15127'
file_name: 2020_ECM_Oshurkova.pdf
file_size: 595543
relation: main_file
success: 1
file_date_updated: 2024-03-20T08:05:46Z
has_accepted_license: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Proceedings of 1st International Electronic Conference on Microbiology
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: Characterization of methanosarcina mazei JL01 isolated from holocene arctic
permafrost and study of the archaeon cooperation with bacterium Sphaerochaeta associata
GLS2T
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '15153'
abstract:
- lang: eng
text: Mammalian circadian rhythms are generated by a transcription-based feedback
loop in which CLOCK:BMAL1 drives transcription of its repressors (PER1/2, CRY1/2),
which ultimately interact with CLOCK:BMAL1 to close the feedback loop with ~24
hr periodicity. Here we pinpoint a key difference between CRY1 and CRY2 that underlies
their differential strengths as transcriptional repressors. Both cryptochromes
bind the BMAL1 transactivation domain similarly to sequester it from coactivators
and repress CLOCK:BMAL1 activity. However, we find that CRY1 is recruited with
much higher affinity to the PAS domain core of CLOCK:BMAL1, allowing it to serve
as a stronger repressor that lengthens circadian period. We discovered a dynamic
serine-rich loop adjacent to the secondary pocket in the photolyase homology region
(PHR) domain that regulates differential binding of cryptochromes to the PAS domain
core of CLOCK:BMAL1. Notably, binding of the co-repressor PER2 remodels the serine
loop of CRY2, making it more CRY1-like and enhancing its affinity for CLOCK:BMAL1.
article_number: '55275'
article_processing_charge: No
article_type: original
author:
- first_name: Jennifer L
full_name: Fribourgh, Jennifer L
last_name: Fribourgh
- first_name: Ashutosh
full_name: Srivastava, Ashutosh
last_name: Srivastava
- first_name: Colby R
full_name: Sandate, Colby R
last_name: Sandate
- first_name: Alicia Kathleen
full_name: Michael, Alicia Kathleen
id: 6437c950-2a03-11ee-914d-d6476dd7b75c
last_name: Michael
- first_name: Peter L
full_name: Hsu, Peter L
last_name: Hsu
- first_name: Christin
full_name: Rakers, Christin
last_name: Rakers
- first_name: Leslee T
full_name: Nguyen, Leslee T
last_name: Nguyen
- first_name: Megan R
full_name: Torgrimson, Megan R
last_name: Torgrimson
- first_name: Gian Carlo G
full_name: Parico, Gian Carlo G
last_name: Parico
- first_name: Sarvind
full_name: Tripathi, Sarvind
last_name: Tripathi
- first_name: Ning
full_name: Zheng, Ning
last_name: Zheng
- first_name: Gabriel C
full_name: Lander, Gabriel C
last_name: Lander
- first_name: Tsuyoshi
full_name: Hirota, Tsuyoshi
last_name: Hirota
- first_name: Florence
full_name: Tama, Florence
last_name: Tama
- first_name: Carrie L
full_name: Partch, Carrie L
last_name: Partch
citation:
ama: Fribourgh JL, Srivastava A, Sandate CR, et al. Dynamics at the serine loop
underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian
timing. eLife. 2020;9. doi:10.7554/elife.55275
apa: Fribourgh, J. L., Srivastava, A., Sandate, C. R., Michael, A. K., Hsu, P. L.,
Rakers, C., … Partch, C. L. (2020). Dynamics at the serine loop underlie differential
affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. ELife.
eLife Sciences Publications. https://doi.org/10.7554/elife.55275
chicago: Fribourgh, Jennifer L, Ashutosh Srivastava, Colby R Sandate, Alicia K.
Michael, Peter L Hsu, Christin Rakers, Leslee T Nguyen, et al. “Dynamics at the
Serine Loop Underlie Differential Affinity of Cryptochromes for CLOCK:BMAL1 to
Control Circadian Timing.” ELife. eLife Sciences Publications, 2020. https://doi.org/10.7554/elife.55275.
ieee: J. L. Fribourgh et al., “Dynamics at the serine loop underlie differential
affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing,” eLife,
vol. 9. eLife Sciences Publications, 2020.
ista: Fribourgh JL, Srivastava A, Sandate CR, Michael AK, Hsu PL, Rakers C, Nguyen
LT, Torgrimson MR, Parico GCG, Tripathi S, Zheng N, Lander GC, Hirota T, Tama
F, Partch CL. 2020. Dynamics at the serine loop underlie differential affinity
of cryptochromes for CLOCK:BMAL1 to control circadian timing. eLife. 9, 55275.
mla: Fribourgh, Jennifer L., et al. “Dynamics at the Serine Loop Underlie Differential
Affinity of Cryptochromes for CLOCK:BMAL1 to Control Circadian Timing.” ELife,
vol. 9, 55275, eLife Sciences Publications, 2020, doi:10.7554/elife.55275.
short: J.L. Fribourgh, A. Srivastava, C.R. Sandate, A.K. Michael, P.L. Hsu, C. Rakers,
L.T. Nguyen, M.R. Torgrimson, G.C.G. Parico, S. Tripathi, N. Zheng, G.C. Lander,
T. Hirota, F. Tama, C.L. Partch, ELife 9 (2020).
date_created: 2024-03-21T07:55:12Z
date_published: 2020-02-26T00:00:00Z
date_updated: 2024-03-25T12:25:02Z
day: '26'
doi: 10.7554/elife.55275
extern: '1'
intvolume: ' 9'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.7554/eLife.55275
month: '02'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamics at the serine loop underlie differential affinity of cryptochromes
for CLOCK:BMAL1 to control circadian timing
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2020'
...
---
_id: '15152'
abstract:
- lang: eng
text: Transcription factors (TFs) regulate gene expression through chromatin where
nucleosomes restrict DNA access. To study how TFs bind nucleosome-occupied motifs,
we focused on the reprogramming factors OCT4 and SOX2 in mouse embryonic stem
cells. We determined TF engagement throughout a nucleosome at base-pair resolution
in vitro, enabling structure determination by cryo–electron microscopy at two
preferred positions. Depending on motif location, OCT4 and SOX2 differentially
distort nucleosomal DNA. At one position, OCT4-SOX2 removes DNA from histone H2A
and histone H3; however, at an inverted motif, the TFs only induce local DNA distortions.
OCT4 uses one of its two DNA-binding domains to engage DNA in both structures,
reading out a partial motif. These findings explain site-specific nucleosome engagement
by the pluripotency factors OCT4 and SOX2, and they reveal how TFs distort nucleosomes
to access chromatinized motifs.
article_processing_charge: No
article_type: original
author:
- first_name: Alicia Kathleen
full_name: Michael, Alicia Kathleen
id: 6437c950-2a03-11ee-914d-d6476dd7b75c
last_name: Michael
orcid: 0000-0002-6080-839X
- first_name: Ralph S.
full_name: Grand, Ralph S.
last_name: Grand
- first_name: Luke
full_name: Isbel, Luke
last_name: Isbel
- first_name: Simone
full_name: Cavadini, Simone
last_name: Cavadini
- first_name: Zuzanna
full_name: Kozicka, Zuzanna
last_name: Kozicka
- first_name: Georg
full_name: Kempf, Georg
last_name: Kempf
- first_name: Richard D.
full_name: Bunker, Richard D.
last_name: Bunker
- first_name: Andreas D.
full_name: Schenk, Andreas D.
last_name: Schenk
- first_name: Alexandra
full_name: Graff-Meyer, Alexandra
last_name: Graff-Meyer
- first_name: Ganesh R.
full_name: Pathare, Ganesh R.
last_name: Pathare
- first_name: Joscha
full_name: Weiss, Joscha
last_name: Weiss
- first_name: Syota
full_name: Matsumoto, Syota
last_name: Matsumoto
- first_name: Lukas
full_name: Burger, Lukas
last_name: Burger
- first_name: Dirk
full_name: Schübeler, Dirk
last_name: Schübeler
- first_name: Nicolas H.
full_name: Thomä, Nicolas H.
last_name: Thomä
citation:
ama: Michael AK, Grand RS, Isbel L, et al. Mechanisms of OCT4-SOX2 motif readout
on nucleosomes. Science. 2020;368(6498):1460-1465. doi:10.1126/science.abb0074
apa: Michael, A. K., Grand, R. S., Isbel, L., Cavadini, S., Kozicka, Z., Kempf,
G., … Thomä, N. H. (2020). Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science. American Association for the Advancement of Science . https://doi.org/10.1126/science.abb0074
chicago: Michael, Alicia K., Ralph S. Grand, Luke Isbel, Simone Cavadini, Zuzanna
Kozicka, Georg Kempf, Richard D. Bunker, et al. “Mechanisms of OCT4-SOX2 Motif
Readout on Nucleosomes.” Science. American Association for the Advancement
of Science , 2020. https://doi.org/10.1126/science.abb0074.
ieee: A. K. Michael et al., “Mechanisms of OCT4-SOX2 motif readout on nucleosomes,”
Science, vol. 368, no. 6498. American Association for the Advancement of
Science , pp. 1460–1465, 2020.
ista: Michael AK, Grand RS, Isbel L, Cavadini S, Kozicka Z, Kempf G, Bunker RD,
Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schübeler
D, Thomä NH. 2020. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science.
368(6498), 1460–1465.
mla: Michael, Alicia K., et al. “Mechanisms of OCT4-SOX2 Motif Readout on Nucleosomes.”
Science, vol. 368, no. 6498, American Association for the Advancement of
Science , 2020, pp. 1460–65, doi:10.1126/science.abb0074.
short: A.K. Michael, R.S. Grand, L. Isbel, S. Cavadini, Z. Kozicka, G. Kempf, R.D.
Bunker, A.D. Schenk, A. Graff-Meyer, G.R. Pathare, J. Weiss, S. Matsumoto, L.
Burger, D. Schübeler, N.H. Thomä, Science 368 (2020) 1460–1465.
date_created: 2024-03-21T07:54:44Z
date_published: 2020-04-23T00:00:00Z
date_updated: 2024-03-25T12:29:34Z
day: '23'
doi: 10.1126/science.abb0074
extern: '1'
intvolume: ' 368'
issue: '6498'
language:
- iso: eng
month: '04'
oa_version: None
page: 1460-1465
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: 'American Association for the Advancement of Science '
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanisms of OCT4-SOX2 motif readout on nucleosomes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 368
year: '2020'
...
---
_id: '7525'
abstract:
- lang: eng
text: "The medial habenula (MHb) is an evolutionary conserved epithalamic structure
important for the modulation of emotional memory. It is involved in regulation
of anxiety, compulsive behavior, addiction (nicotinic and opioid), sexual and
feeding behavior. MHb receives inputs from septal regions and projects exclusively
to the interpeduncular nucleus (IPN). Distinct sub-regions of the septum project
to different subnuclei of MHb: the bed nucleus of anterior commissure projects
to dorsal MHb and the triangular septum projects to ventral MHb. Furthermore,
the dorsal and ventral MHb project to the lateral and rostral/central IPN, respectively.
Importantly, these projections have unique features of prominent co-release of
different neurotransmitters and requirement of a peculiar type of calcium channel
for release. In general, synaptic neurotransmission requires an activity-dependent
influx of Ca2+ into the presynaptic terminal through voltage-gated calcium channels.
The calcium channel family most commonly involved in neurotransmitter release
comprises three members, P/Q-, N- and R-type with Cav2.1, Cav2.2 and Cav2.3 subunits,
respectively. In contrast to most CNS synapses that mainly express Cav2.1 and/or
Cav2.2, MHb terminals in the IPN exclusively express Cav2.3. In other parts of
the brain, such as the hippocampus, Cav2.3 is mostly located to postsynaptic elements.
This unusual presynaptic location of Cav2.3 in the MHb-IPN pathway implies unique
mechanisms of glutamate release in this pathway. One potential example of such
uniqueness is the facilitation of release by GABAB receptor (GBR) activation.
Presynaptic GBRs usually inhibit the release of neurotransmitters by inhibiting
presynaptic calcium channels. MHb shows the highest expression levels of GBR in
the brain. GBRs comprise two subunits, GABAB1 (GB1) and GABAB2 (GB2), and are
associated with auxiliary subunits, called potassium channel tetramerization domain
containing proteins (KCTD) 8, 12, 12b and 16. Among these four subunits, KCTD12b
is exclusively expressed in ventral MHb, and KCTD8 shows the strongest expression
in the whole MHb among other brain regions, indicating that KCTD8 and KCTD12b
may be involved in the unique mechanisms of neurotransmitter release mediated
by Cav2.3 and regulated by GBRs in this pathway. \r\nIn the present study, we
first verified that neurotransmission in both dorsal and ventral MHb-IPN pathways
is mainly mediated by Cav2.3 using a selective blocker of R-type channels, SNX-482.
We next found that baclofen, a GBR agonist, has facilitatory effects on release
from ventral MHb terminal in rostral IPN, whereas it has inhibitory effects on
release from dorsal MHb terminals in lateral IPN, indicating that KCTD12b expressed
exclusively in ventral MHb may have a role in the facilitatory effects of GBR
activation. In a heterologous expression system using HEK cells, we found that
KCTD8 and KCTD12b but not KCTD12 directly bind with Cav2.3. Pre-embedding immunogold
electron microscopy data show that Cav2.3 and KCTD12b are distributed most densely
in presynaptic active zone in IPN with KCTD12b being present only in rostral/central
but not lateral IPN, whereas GABAB, KCTD8 and KCTD12 are distributed most densely
in perisynaptic sites with KCTD12 present more frequently in postsynaptic elements
and only in rostral/central IPN. In freeze-fracture replica labelling, Cav2.3,
KCTD8 and KCTD12b are co-localized with each other in the same active zone indicating
that they may form complexes regulating vesicle release in rostral IPN. \r\nOn
electrophysiological studies of wild type (WT) mice, we found that paired-pulse
ratio in rostral IPN of KCTD12b knock-out (KO) mice is lower than those of WT
and KCTD8 KO mice. Consistent with this finding, in mean variance analysis, release
probability in rostral IPN of KCTD12b KO mice is higher than that of WT and KCTD8
KO mice. Although paired-pulse ratios are not different between WT and KCTD8 KO
mice, the mean variance analysis revealed significantly lower release probability
in rostral IPN of KCTD8 KO than WT mice. These results demonstrate bidirectional
regulation of Cav2.3-mediated release by KCTD8 and KCTD12b without GBR activation
in rostral IPN. Finally, we examined the baclofen effects in rostral IPN of KCTD8
and KCTD12b KO mice, and found the facilitation of release remained in both KO
mice, indicating that the peculiar effects of the GBR activation in this pathway
do not depend on the selective expression of these KCTD subunits in ventral MHb.
However, we found that presynaptic potentiation of evoked EPSC amplitude by baclofen
falls to baseline after washout faster in KCTD12b KO mice than WT, KCTD8 KO and
KCTD8/12b double KO mice. This result indicates that KCTD12b is involved in sustained
potentiation of vesicle release by GBR activation, whereas KCTD8 is involved in
its termination in the absence of KCTD12b. Consistent with these functional findings,
replica labelling revealed an increase in density of KCTD8, but not Cav2.3 or
GBR at active zone in rostral IPN of KCTD12b KO mice compared with that of WT
mice, suggesting that increased association of KCTD8 with Cav2.3 facilitates the
release probability and termination of the GBR effect in the absence of KCTD12b.\r\nIn
summary, our study provided new insights into the physiological roles of presynaptic
Cav2.3, GBRs and their auxiliary subunits KCTDs at an evolutionary conserved neuronal
circuit. Future studies will be required to identify the exact molecular mechanism
underlying the GBR-mediated presynaptic potentiation on ventral MHb terminals.
It remains to be determined whether the prominent presence of presynaptic KCTDs
at active zone could exert similar neuromodulatory functions in different pathways
of the brain.\r\n"
acknowledged_ssus:
- _id: EM-Fac
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Pradeep
full_name: Bhandari, Pradeep
id: 45EDD1BC-F248-11E8-B48F-1D18A9856A87
last_name: Bhandari
orcid: 0000-0003-0863-4481
citation:
ama: Bhandari P. Localization and functional role of Cav2.3 in the medial habenula
to interpeduncular nucleus pathway. 2020. doi:10.15479/AT:ISTA:7525
apa: Bhandari, P. (2020). Localization and functional role of Cav2.3 in the medial
habenula to interpeduncular nucleus pathway. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:7525
chicago: Bhandari, Pradeep. “Localization and Functional Role of Cav2.3 in the Medial
Habenula to Interpeduncular Nucleus Pathway.” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:7525.
ieee: P. Bhandari, “Localization and functional role of Cav2.3 in the medial habenula
to interpeduncular nucleus pathway,” Institute of Science and Technology Austria,
2020.
ista: Bhandari P. 2020. Localization and functional role of Cav2.3 in the medial
habenula to interpeduncular nucleus pathway. Institute of Science and Technology
Austria.
mla: Bhandari, Pradeep. Localization and Functional Role of Cav2.3 in the Medial
Habenula to Interpeduncular Nucleus Pathway. Institute of Science and Technology
Austria, 2020, doi:10.15479/AT:ISTA:7525.
short: P. Bhandari, Localization and Functional Role of Cav2.3 in the Medial Habenula
to Interpeduncular Nucleus Pathway, Institute of Science and Technology Austria,
2020.
date_created: 2020-02-26T10:56:37Z
date_published: 2020-02-28T00:00:00Z
date_updated: 2023-09-07T13:20:03Z
day: '28'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: RySh
doi: 10.15479/AT:ISTA:7525
file:
- access_level: open_access
checksum: 4589234fdb12b4ad72273b311723a7b4
content_type: application/pdf
creator: pbhandari
date_created: 2020-02-28T08:37:53Z
date_updated: 2021-03-01T23:30:04Z
embargo: 2021-02-28
file_id: '7538'
file_name: Pradeep Bhandari Thesis.pdf
file_size: 9646346
relation: main_file
title: Localization and functional role of Cav2.3 in the medial habenula to interpeduncular
nucleus pathway
- access_level: closed
checksum: aa79490553ca0a5c9b6fbcd152e93928
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: pbhandari
date_created: 2020-02-28T08:47:14Z
date_updated: 2021-03-01T23:30:04Z
embargo_to: open_access
file_id: '7539'
file_name: Pradeep Bhandari Thesis.docx
file_size: 35252164
relation: source_file
title: Localization and functional role of Cav2.3 in the medial habenula to interpeduncular
nucleus pathway
file_date_updated: 2021-03-01T23:30:04Z
has_accepted_license: '1'
keyword:
- Cav2.3
- medial habenula (MHb)
- interpeduncular nucleus (IPN)
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '79'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
title: Localization and functional role of Cav2.3 in the medial habenula to interpeduncular
nucleus pathway
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '8586'
abstract:
- lang: eng
text: Cryo-electron microscopy (cryo-EM) of cellular specimens provides insights
into biological processes and structures within a native context. However, a major
challenge still lies in the efficient and reproducible preparation of adherent
cells for subsequent cryo-EM analysis. This is due to the sensitivity of many
cellular specimens to the varying seeding and culturing conditions required for
EM experiments, the often limited amount of cellular material and also the fragility
of EM grids and their substrate. Here, we present low-cost and reusable 3D printed
grid holders, designed to improve specimen preparation when culturing challenging
cellular samples directly on grids. The described grid holders increase cell culture
reproducibility and throughput, and reduce the resources required for cell culturing.
We show that grid holders can be integrated into various cryo-EM workflows, including
micro-patterning approaches to control cell seeding on grids, and for generating
samples for cryo-focused ion beam milling and cryo-electron tomography experiments.
Their adaptable design allows for the generation of specialized grid holders customized
to a large variety of applications.
acknowledged_ssus:
- _id: ScienComp
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
acknowledgement: This work was supported by the Austrian Science Fund (FWF, P33367)
to FKMS. BZ acknowledges support by the Niederösterreich Fond. This research was
also supported by the Scientific Service Units (SSU) of IST Austria through resources
provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the
BioImaging Facility (BIF) and the Electron Microscopy Facility (EMF). We thank Georgi
Dimchev (IST Austria) and Sonja Jacob (Vienna Biocenter Core Facilities) for testing
our grid holders in different experimental setups and Daniel Gütl and the Kondrashov
group (IST Austria) for granting us repeated access to their 3D printers. We also
thank Jonna Alanko and the Sixt lab (IST Austria) for providing us HeLa cells, primary
BL6 mouse tail fibroblasts, NIH 3T3 fibroblasts and human telomerase immortalised
foreskin fibroblasts for our experiments. We are thankful to Ori Avinoam and William
Wan for helpful comments on the manuscript and also thank Dorotea Fracchiolla (Art&Science)
for illustrating the graphical abstract.
article_number: '107633'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Florian
full_name: Fäßler, Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- first_name: Bettina
full_name: Zens, Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
orcid: 0000-0002-9561-1239
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Fäßler F, Zens B, Hauschild R, Schur FK. 3D printed cell culture grid holders
for improved cellular specimen preparation in cryo-electron microscopy. Journal
of Structural Biology. 2020;212(3). doi:10.1016/j.jsb.2020.107633
apa: Fäßler, F., Zens, B., Hauschild, R., & Schur, F. K. (2020). 3D printed
cell culture grid holders for improved cellular specimen preparation in cryo-electron
microscopy. Journal of Structural Biology. Elsevier. https://doi.org/10.1016/j.jsb.2020.107633
chicago: Fäßler, Florian, Bettina Zens, Robert Hauschild, and Florian KM Schur.
“3D Printed Cell Culture Grid Holders for Improved Cellular Specimen Preparation
in Cryo-Electron Microscopy.” Journal of Structural Biology. Elsevier,
2020. https://doi.org/10.1016/j.jsb.2020.107633.
ieee: F. Fäßler, B. Zens, R. Hauschild, and F. K. Schur, “3D printed cell culture
grid holders for improved cellular specimen preparation in cryo-electron microscopy,”
Journal of Structural Biology, vol. 212, no. 3. Elsevier, 2020.
ista: Fäßler F, Zens B, Hauschild R, Schur FK. 2020. 3D printed cell culture grid
holders for improved cellular specimen preparation in cryo-electron microscopy.
Journal of Structural Biology. 212(3), 107633.
mla: Fäßler, Florian, et al. “3D Printed Cell Culture Grid Holders for Improved
Cellular Specimen Preparation in Cryo-Electron Microscopy.” Journal of Structural
Biology, vol. 212, no. 3, 107633, Elsevier, 2020, doi:10.1016/j.jsb.2020.107633.
short: F. Fäßler, B. Zens, R. Hauschild, F.K. Schur, Journal of Structural Biology
212 (2020).
date_created: 2020-09-29T13:24:06Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-03-27T23:30:05Z
day: '01'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1016/j.jsb.2020.107633
external_id:
isi:
- '000600997800008'
file:
- access_level: open_access
checksum: c48cbf594e84fc2f91966ffaafc0918c
content_type: application/pdf
creator: dernst
date_created: 2020-12-10T14:01:10Z
date_updated: 2020-12-10T14:01:10Z
file_id: '8937'
file_name: 2020_JourStrucBiology_Faessler.pdf
file_size: 7076870
relation: main_file
success: 1
file_date_updated: 2020-12-10T14:01:10Z
has_accepted_license: '1'
intvolume: ' 212'
isi: 1
issue: '3'
keyword:
- electron microscopy
- cryo-EM
- EM sample preparation
- 3D printing
- cell culture
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
- _id: 059B463C-7A3F-11EA-A408-12923DDC885E
name: NÖ-Fonds Preis für die Jungforscherin des Jahres am IST Austria
publication: Journal of Structural Biology
publication_identifier:
issn:
- 1047-8477
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '14592'
relation: used_in_publication
status: public
- id: '12491'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 3D printed cell culture grid holders for improved cellular specimen preparation
in cryo-electron microscopy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 212
year: '2020'
...
---
_id: '8657'
abstract:
- lang: eng
text: "Synthesis of proteins – translation – is a fundamental process of life. Quantitative
studies anchor translation into the context of bacterial physiology and reveal
several mathematical relationships, called “growth laws,” which capture physiological
feedbacks between protein synthesis and cell growth. Growth laws describe the
dependency of the ribosome abundance as a function of growth rate, which can change
depending on the growth conditions. Perturbations of translation reveal that bacteria
employ a compensatory strategy in which the reduced translation capability results
in increased expression of the translation machinery.\r\nPerturbations of translation
are achieved in various ways; clinically interesting is the application of translation-targeting
antibiotics – translation inhibitors. The antibiotic effects on bacterial physiology
are often poorly understood. Bacterial responses to two or more simultaneously
applied antibiotics are even more puzzling. The combined antibiotic effect determines
the type of drug interaction, which ranges from synergy (the effect is stronger
than expected) to antagonism (the effect is weaker) and suppression (one of the
drugs loses its potency).\r\nIn the first part of this work, we systematically
measure the pairwise interaction network for translation inhibitors that interfere
with different steps in translation. We find that the interactions are surprisingly
diverse and tend to be more antagonistic. To explore the underlying mechanisms,
we begin with a minimal biophysical model of combined antibiotic action. We base
this model on the kinetics of antibiotic uptake and binding together with the
physiological response described by the growth laws. The biophysical model explains
some drug interactions, but not all; it specifically fails to predict suppression.\r\nIn
the second part of this work, we hypothesize that elusive suppressive drug interactions
result from the interplay between ribosomes halted in different stages of translation.
To elucidate this putative mechanism of drug interactions between translation
inhibitors, we generate translation bottlenecks genetically using in- ducible
control of translation factors that regulate well-defined translation cycle steps.
These perturbations accurately mimic antibiotic action and drug interactions,
supporting that the interplay of different translation bottlenecks partially causes
these interactions.\r\nWe extend this approach by varying two translation bottlenecks
simultaneously. This approach reveals the suppression of translocation inhibition
by inhibited translation. We rationalize this effect by modeling dense traffic
of ribosomes that move on transcripts in a translation factor-mediated manner.
This model predicts a dissolution of traffic jams caused by inhibited translocation
when the density of ribosome traffic is reduced by lowered initiation. We base
this model on the growth laws and quantitative relationships between different
translation and growth parameters.\r\nIn the final part of this work, we describe
a set of tools aimed at quantification of physiological and translation parameters.
We further develop a simple model that directly connects the abundance of a translation
factor with the growth rate, which allows us to extract physiological parameters
describing initiation. We demonstrate the development of tools for measuring translation
rate.\r\nThis thesis showcases how a combination of high-throughput growth rate
mea- surements, genetics, and modeling can reveal mechanisms of drug interactions.
Furthermore, by a gradual transition from combinations of antibiotics to precise
genetic interventions, we demonstrated the equivalency between genetic and chemi-
cal perturbations of translation. These findings tile the path for quantitative
studies of antibiotic combinations and illustrate future approaches towards the
quantitative description of translation."
acknowledged_ssus:
- _id: LifeSc
- _id: M-Shop
acknowledgement: I thank Life Science Facilities for their continuous support with
providing top-notch laboratory materials, keeping the devices humming, and coordinating
the repairs and building of custom-designed laboratory equipment with the MIBA Machine
shop.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Bor
full_name: Kavcic, Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
citation:
ama: 'Kavcic B. Perturbations of protein synthesis: from antibiotics to genetics
and physiology. 2020. doi:10.15479/AT:ISTA:8657'
apa: 'Kavcic, B. (2020). Perturbations of protein synthesis: from antibiotics
to genetics and physiology. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8657'
chicago: 'Kavcic, Bor. “Perturbations of Protein Synthesis: From Antibiotics to
Genetics and Physiology.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8657.'
ieee: 'B. Kavcic, “Perturbations of protein synthesis: from antibiotics to genetics
and physiology,” Institute of Science and Technology Austria, 2020.'
ista: 'Kavcic B. 2020. Perturbations of protein synthesis: from antibiotics to genetics
and physiology. Institute of Science and Technology Austria.'
mla: 'Kavcic, Bor. Perturbations of Protein Synthesis: From Antibiotics to Genetics
and Physiology. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8657.'
short: 'B. Kavcic, Perturbations of Protein Synthesis: From Antibiotics to Genetics
and Physiology, Institute of Science and Technology Austria, 2020.'
date_created: 2020-10-13T16:46:14Z
date_published: 2020-10-14T00:00:00Z
date_updated: 2023-09-07T13:20:48Z
day: '14'
ddc:
- '571'
- '530'
- '570'
degree_awarded: PhD
department:
- _id: GaTk
doi: 10.15479/AT:ISTA:8657
file:
- access_level: open_access
checksum: d708ecd62b6fcc3bc1feb483b8dbe9eb
content_type: application/pdf
creator: bkavcic
date_created: 2020-10-15T06:41:20Z
date_updated: 2021-10-07T22:30:03Z
embargo: 2021-10-06
file_id: '8663'
file_name: kavcicB_thesis202009.pdf
file_size: 52636162
relation: main_file
- access_level: closed
checksum: bb35f2352a04db19164da609f00501f3
content_type: application/zip
creator: bkavcic
date_created: 2020-10-15T06:41:53Z
date_updated: 2021-10-07T22:30:03Z
embargo_to: open_access
file_id: '8664'
file_name: 2020b.zip
file_size: 321681247
relation: source_file
file_date_updated: 2021-10-07T22:30:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '271'
publication_identifier:
isbn:
- 978-3-99078-011-4
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7673'
relation: part_of_dissertation
status: public
- id: '8250'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
title: 'Perturbations of protein synthesis: from antibiotics to genetics and physiology'
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '7473'
abstract:
- lang: eng
text: How structural and functional properties of synapses relate to each other
is a fundamental question in neuroscience. Electrophysiology has elucidated mechanisms
of synaptic transmission, and electron microscopy (EM) has provided insight into
morphological properties of synapses. Here we describe an enhanced method for
functional EM (“flash and freeze”), combining optogenetic stimulation with high-pressure
freezing. We demonstrate that the improved method can be applied to intact networks
in acute brain slices and organotypic slice cultures from mice. As a proof of
concept, we probed vesicle pool changes during synaptic transmission at the hippocampal
mossy fiber-CA3 pyramidal neuron synapse. Our findings show overlap of the docked
vesicle pool and the functionally defined readily releasable pool and provide
evidence of fast endocytosis at this synapse. Functional EM with acute slices
and slice cultures has the potential to reveal the structural and functional mechanisms
of transmission in intact, genetically perturbed, and disease-affected synapses.
acknowledgement: This project has received funding from the European Research Council
(ERC) and European Commission (EC), under the European Union’s Horizon 2020 research
and innovation programme (ERC grant agreement No. 692692 and Marie Sklodowska-Curie
708497) and from Fonds zur Förderung der Wissenschaftlichen Forschung (Z 312-B27
Wittgenstein award and DK W1205-B09). We thank Johann Danzl and Ryuichi Shigemoto
for critically reading the manuscript; Walter Kaufmann, Daniel Gutl, and Vanessa
Zheden for extensive EM training, advice, and experimental assistance; Benjamin
Suter for substantial help with light stimulation, ImageJ plugins for analysis,
and manuscript editing; Florian Marr and Christina Altmutter for technical support;
Eleftheria Kralli-Beller for manuscript editing; Julia König and Paul Wurzinger
(Leica Microsystems) for helpful technical discussions; and Taija Makinen for providing
the Prox1-CreERT2 mouse line.
article_processing_charge: No
article_type: original
author:
- first_name: Carolina
full_name: Borges Merjane, Carolina
id: 4305C450-F248-11E8-B48F-1D18A9856A87
last_name: Borges Merjane
orcid: 0000-0003-0005-401X
- first_name: Olena
full_name: Kim, Olena
id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87
last_name: Kim
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Borges Merjane C, Kim O, Jonas PM. Functional electron microscopy (“Flash and
Freeze”) of identified cortical synapses in acute brain slices. Neuron.
2020;105:992-1006. doi:10.1016/j.neuron.2019.12.022
apa: Borges Merjane, C., Kim, O., & Jonas, P. M. (2020). Functional electron
microscopy (“Flash and Freeze”) of identified cortical synapses in acute brain
slices. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2019.12.022
chicago: Borges Merjane, Carolina, Olena Kim, and Peter M Jonas. “Functional Electron
Microscopy (‘Flash and Freeze’) of Identified Cortical Synapses in Acute Brain
Slices.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2019.12.022.
ieee: C. Borges Merjane, O. Kim, and P. M. Jonas, “Functional electron microscopy
(‘Flash and Freeze’) of identified cortical synapses in acute brain slices,” Neuron,
vol. 105. Elsevier, pp. 992–1006, 2020.
ista: Borges Merjane C, Kim O, Jonas PM. 2020. Functional electron microscopy (“Flash
and Freeze”) of identified cortical synapses in acute brain slices. Neuron. 105,
992–1006.
mla: Borges Merjane, Carolina, et al. “Functional Electron Microscopy (‘Flash and
Freeze’) of Identified Cortical Synapses in Acute Brain Slices.” Neuron,
vol. 105, Elsevier, 2020, pp. 992–1006, doi:10.1016/j.neuron.2019.12.022.
short: C. Borges Merjane, O. Kim, P.M. Jonas, Neuron 105 (2020) 992–1006.
date_created: 2020-02-10T15:59:45Z
date_published: 2020-03-18T00:00:00Z
date_updated: 2024-03-27T23:30:07Z
day: '18'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2019.12.022
ec_funded: 1
external_id:
isi:
- '000520854700008'
pmid:
- '31928842'
file:
- access_level: open_access
checksum: 3582664addf26859e86ac5bec3e01416
content_type: application/pdf
creator: dernst
date_created: 2020-11-20T08:58:53Z
date_updated: 2020-11-20T08:58:53Z
file_id: '8778'
file_name: 2020_Neuron_BorgesMerjane.pdf
file_size: 9712957
relation: main_file
success: 1
file_date_updated: 2020-11-20T08:58:53Z
has_accepted_license: '1'
intvolume: ' 105'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 992-1006
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 25BAF7B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '708497'
name: Presynaptic calcium channels distribution and impact on coupling at the hippocampal
mossy fiber synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
- _id: 25C3DBB6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W01205
name: Zellkommunikation in Gesundheit und Krankheit
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/flash-and-freeze-reveals-dynamics-of-nerve-connections/
record:
- id: '11196'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Functional electron microscopy (“Flash and Freeze”) of identified cortical
synapses in acute brain slices
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2020'
...
---
_id: '8250'
abstract:
- lang: eng
text: 'Antibiotics that interfere with translation, when combined, interact in diverse
and difficult-to-predict ways. Here, we explain these interactions by “translation
bottlenecks”: points in the translation cycle where antibiotics block ribosomal
progression. To elucidate the underlying mechanisms of drug interactions between
translation inhibitors, we generate translation bottlenecks genetically using
inducible control of translation factors that regulate well-defined translation
cycle steps. These perturbations accurately mimic antibiotic action and drug interactions,
supporting that the interplay of different translation bottlenecks causes these
interactions. We further show that growth laws, combined with drug uptake and
binding kinetics, enable the direct prediction of a large fraction of observed
interactions, yet fail to predict suppression. However, varying two translation
bottlenecks simultaneously supports that dense traffic of ribosomes and competition
for translation factors account for the previously unexplained suppression. These
results highlight the importance of “continuous epistasis” in bacterial physiology.'
acknowledgement: "We thank M. Hennessey-Wesen, I. Tomanek, K. Jain, A. Staron, K.
Tomasek, M. Scott,\r\nK.C. Huang, and Z. Gitai for reading the manuscript and constructive
comments. B.K. is\r\nindebted to C. Guet for additional guidance and generous support,
which rendered this\r\nwork possible. B.K. thanks all members of Guet group for
many helpful discussions and\r\nsharing of resources. B.K. additionally acknowledges
the tremendous support from A.\r\nAngermayr and K. Mitosch with experimental work.
We further thank E. Brown for\r\nhelpful comments regarding lamotrigine, and A.
Buskirk for valuable suggestions\r\nregarding the ribosome footprint size. This
work was supported in part by Austrian\r\nScience Fund (FWF) standalone grants P
27201-B22 (to T.B.) and P 28844 (to G.T.),\r\nHFSP program Grant RGP0042/2013 (to
T.B.), German Research Foundation (DFG)\r\nstandalone grant BO 3502/2-1 (to T.B.),
and German Research Foundation (DFG)\r\nCollaborative Research Centre (SFB) 1310
(to T.B.). Open access funding provided by\r\nProjekt DEAL."
article_number: '4013'
article_processing_charge: No
article_type: original
author:
- first_name: Bor
full_name: Kavcic, Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Tobias
full_name: Bollenbach, Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
citation:
ama: Kavcic B, Tkačik G, Bollenbach MT. Mechanisms of drug interactions between
translation-inhibiting antibiotics. Nature Communications. 2020;11. doi:10.1038/s41467-020-17734-z
apa: Kavcic, B., Tkačik, G., & Bollenbach, M. T. (2020). Mechanisms of drug
interactions between translation-inhibiting antibiotics. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-020-17734-z
chicago: Kavcic, Bor, Gašper Tkačik, and Mark Tobias Bollenbach. “Mechanisms of
Drug Interactions between Translation-Inhibiting Antibiotics.” Nature Communications.
Springer Nature, 2020. https://doi.org/10.1038/s41467-020-17734-z.
ieee: B. Kavcic, G. Tkačik, and M. T. Bollenbach, “Mechanisms of drug interactions
between translation-inhibiting antibiotics,” Nature Communications, vol.
11. Springer Nature, 2020.
ista: Kavcic B, Tkačik G, Bollenbach MT. 2020. Mechanisms of drug interactions between
translation-inhibiting antibiotics. Nature Communications. 11, 4013.
mla: Kavcic, Bor, et al. “Mechanisms of Drug Interactions between Translation-Inhibiting
Antibiotics.” Nature Communications, vol. 11, 4013, Springer Nature, 2020,
doi:10.1038/s41467-020-17734-z.
short: B. Kavcic, G. Tkačik, M.T. Bollenbach, Nature Communications 11 (2020).
date_created: 2020-08-12T09:13:50Z
date_published: 2020-08-11T00:00:00Z
date_updated: 2024-03-27T23:30:08Z
day: '11'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1038/s41467-020-17734-z
external_id:
isi:
- '000562769300008'
file:
- access_level: open_access
checksum: 986bebb308850a55850028d3d2b5b664
content_type: application/pdf
creator: dernst
date_created: 2020-08-17T07:36:57Z
date_updated: 2020-08-17T07:36:57Z
file_id: '8275'
file_name: 2020_NatureComm_Kavcic.pdf
file_size: 1965672
relation: main_file
success: 1
file_date_updated: 2020-08-17T07:36:57Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25E9AF9E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27201-B22
name: Revealing the mechanisms underlying drug interactions
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '8657'
relation: dissertation_contains
status: public
status: public
title: Mechanisms of drug interactions between translation-inhibiting antibiotics
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2020'
...
---
_id: '7673'
abstract:
- lang: eng
text: Combining drugs can improve the efficacy of treatments. However, predicting
the effect of drug combinations is still challenging. The combined potency of
drugs determines the drug interaction, which is classified as synergistic, additive,
antagonistic, or suppressive. While probabilistic, non-mechanistic models exist,
there is currently no biophysical model that can predict antibiotic interactions.
Here, we present a physiologically relevant model of the combined action of antibiotics
that inhibit protein synthesis by targeting the ribosome. This model captures
the kinetics of antibiotic binding and transport, and uses bacterial growth laws
to predict growth in the presence of antibiotic combinations. We find that this
biophysical model can produce all drug interaction types except suppression. We
show analytically that antibiotics which cannot bind to the ribosome simultaneously
generally act as substitutes for one another, leading to additive drug interactions.
Previously proposed null expectations for higher-order drug interactions follow
as a limiting case of our model. We further extend the model to include the effects
of direct physical or allosteric interactions between individual drugs on the
ribosome. Notably, such direct interactions profoundly change the combined drug
effect, depending on the kinetic parameters of the drugs used. The model makes
additional predictions for the effects of resistance genes on drug interactions
and for interactions between ribosome-targeting antibiotics and antibiotics with
other targets. These findings enhance our understanding of the interplay between
drug action and cell physiology and are a key step toward a general framework
for predicting drug interactions.
article_processing_charge: No
author:
- first_name: Bor
full_name: Kavcic, Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Tobias
full_name: Bollenbach, Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
citation:
ama: Kavcic B, Tkačik G, Bollenbach MT. A minimal biophysical model of combined
antibiotic action. bioRxiv. 2020. doi:10.1101/2020.04.18.047886
apa: Kavcic, B., Tkačik, G., & Bollenbach, M. T. (2020). A minimal biophysical
model of combined antibiotic action. bioRxiv. Cold Spring Harbor Laboratory.
https://doi.org/10.1101/2020.04.18.047886
chicago: Kavcic, Bor, Gašper Tkačik, and Mark Tobias Bollenbach. “A Minimal Biophysical
Model of Combined Antibiotic Action.” BioRxiv. Cold Spring Harbor Laboratory,
2020. https://doi.org/10.1101/2020.04.18.047886.
ieee: B. Kavcic, G. Tkačik, and M. T. Bollenbach, “A minimal biophysical model of
combined antibiotic action,” bioRxiv. Cold Spring Harbor Laboratory, 2020.
ista: Kavcic B, Tkačik G, Bollenbach MT. 2020. A minimal biophysical model of combined
antibiotic action. bioRxiv, 10.1101/2020.04.18.047886.
mla: Kavcic, Bor, et al. “A Minimal Biophysical Model of Combined Antibiotic Action.”
BioRxiv, Cold Spring Harbor Laboratory, 2020, doi:10.1101/2020.04.18.047886.
short: B. Kavcic, G. Tkačik, M.T. Bollenbach, BioRxiv (2020).
date_created: 2020-04-22T08:27:56Z
date_published: 2020-04-18T00:00:00Z
date_updated: 2024-03-27T23:30:08Z
day: '18'
department:
- _id: GaTk
doi: 10.1101/2020.04.18.047886
language:
- iso: eng
main_file_link:
- open_access: '1'
url: 'https://doi.org/10.1101/2020.04.18.047886 '
month: '04'
oa: 1
oa_version: Preprint
project:
- _id: 25E9AF9E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27201-B22
name: Revealing the mechanisms underlying drug interactions
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
publication: bioRxiv
publication_status: published
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '8997'
relation: later_version
status: public
- id: '8657'
relation: dissertation_contains
status: public
status: public
title: A minimal biophysical model of combined antibiotic action
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8002'
abstract:
- lang: eng
text: Wound healing in plant tissues, consisting of rigid cell wall-encapsulated
cells, represents a considerable challenge and occurs through largely unknown
mechanisms distinct from those in animals. Owing to their inability to migrate,
plant cells rely on targeted cell division and expansion to regenerate wounds.
Strict coordination of these wound-induced responses is essential to ensure efficient,
spatially restricted wound healing. Single-cell tracking by live imaging allowed
us to gain mechanistic insight into the wound perception and coordination of wound
responses after laser-based wounding in Arabidopsis root. We revealed a crucial
contribution of the collapse of damaged cells in wound perception and detected
an auxin increase specific to cells immediately adjacent to the wound. This localized
auxin increase balances wound-induced cell expansion and restorative division
rates in a dose-dependent manner, leading to tumorous overproliferation when the
canonical TIR1 auxin signaling is disrupted. Auxin and wound-induced turgor pressure
changes together also spatially define the activation of key components of regeneration,
such as the transcription regulator ERF115. Our observations suggest that the
wound signaling involves the sensing of collapse of damaged cells and a local
auxin signaling activation to coordinate the downstream transcriptional responses
in the immediate wound vicinity.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
article_number: '202003346'
article_processing_charge: No
article_type: original
author:
- first_name: Lukas
full_name: Hörmayer, Lukas
id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87
last_name: Hörmayer
orcid: 0000-0001-8295-2926
- first_name: Juan C
full_name: Montesinos López, Juan C
id: 310A8E3E-F248-11E8-B48F-1D18A9856A87
last_name: Montesinos López
orcid: 0000-0001-9179-6099
- first_name: Petra
full_name: Marhavá, Petra
id: 44E59624-F248-11E8-B48F-1D18A9856A87
last_name: Marhavá
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Saiko
full_name: Yoshida, Saiko
id: 2E46069C-F248-11E8-B48F-1D18A9856A87
last_name: Yoshida
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Hörmayer L, Montesinos López JC, Marhavá P, Benková E, Yoshida S, Friml J.
Wounding-induced changes in cellular pressure and localized auxin signalling spatially
coordinate restorative divisions in roots. Proceedings of the National Academy
of Sciences. 2020;117(26). doi:10.1073/pnas.2003346117
apa: Hörmayer, L., Montesinos López, J. C., Marhavá, P., Benková, E., Yoshida, S.,
& Friml, J. (2020). Wounding-induced changes in cellular pressure and localized
auxin signalling spatially coordinate restorative divisions in roots. Proceedings
of the National Academy of Sciences. Proceedings of the National Academy of
Sciences. https://doi.org/10.1073/pnas.2003346117
chicago: Hörmayer, Lukas, Juan C Montesinos López, Petra Marhavá, Eva Benková, Saiko
Yoshida, and Jiří Friml. “Wounding-Induced Changes in Cellular Pressure and Localized
Auxin Signalling Spatially Coordinate Restorative Divisions in Roots.” Proceedings
of the National Academy of Sciences. Proceedings of the National Academy of
Sciences, 2020. https://doi.org/10.1073/pnas.2003346117.
ieee: L. Hörmayer, J. C. Montesinos López, P. Marhavá, E. Benková, S. Yoshida, and
J. Friml, “Wounding-induced changes in cellular pressure and localized auxin signalling
spatially coordinate restorative divisions in roots,” Proceedings of the National
Academy of Sciences, vol. 117, no. 26. Proceedings of the National Academy
of Sciences, 2020.
ista: Hörmayer L, Montesinos López JC, Marhavá P, Benková E, Yoshida S, Friml J.
2020. Wounding-induced changes in cellular pressure and localized auxin signalling
spatially coordinate restorative divisions in roots. Proceedings of the National
Academy of Sciences. 117(26), 202003346.
mla: Hörmayer, Lukas, et al. “Wounding-Induced Changes in Cellular Pressure and
Localized Auxin Signalling Spatially Coordinate Restorative Divisions in Roots.”
Proceedings of the National Academy of Sciences, vol. 117, no. 26, 202003346,
Proceedings of the National Academy of Sciences, 2020, doi:10.1073/pnas.2003346117.
short: L. Hörmayer, J.C. Montesinos López, P. Marhavá, E. Benková, S. Yoshida, J.
Friml, Proceedings of the National Academy of Sciences 117 (2020).
date_created: 2020-06-22T13:33:52Z
date_published: 2020-06-30T00:00:00Z
date_updated: 2024-03-27T23:30:11Z
day: '30'
ddc:
- '580'
department:
- _id: JiFr
- _id: EvBe
doi: 10.1073/pnas.2003346117
ec_funded: 1
external_id:
isi:
- '000565729700033'
pmid:
- '32541049'
file:
- access_level: open_access
checksum: 908b09437680181de9990915f2113aca
content_type: application/pdf
creator: dernst
date_created: 2020-06-23T11:30:53Z
date_updated: 2020-07-14T12:48:07Z
file_id: '8009'
file_name: 2020_PNAS_Hoermayer.pdf
file_size: 2407102
relation: main_file
file_date_updated: 2020-07-14T12:48:07Z
has_accepted_license: '1'
intvolume: ' 117'
isi: 1
issue: '26'
language:
- iso: eng
month: '06'
oa: 1
oa_version: None
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 262EF96E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29988
name: RNA-directed DNA methylation in plant development
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/how-wounded-plants-coordinate-their-healing/
record:
- id: '9992'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Wounding-induced changes in cellular pressure and localized auxin signalling
spatially coordinate restorative divisions in roots
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 117
year: '2020'
...
---
_id: '7680'
abstract:
- lang: eng
text: "Proteins and their complex dynamic interactions regulate cellular mechanisms
from sensing and transducing extracellular signals, to mediating genetic responses,
and sustaining or changing cell morphology. To manipulate these protein-protein
interactions (PPIs) that govern the behavior and fate of cells, synthetically
constructed, genetically encoded tools provide the means to precisely target proteins
of interest (POIs), and control their subcellular localization and activity in
vitro and in vivo. Ideal synthetic tools react to an orthogonal cue, i.e. a trigger
that does not activate any other endogenous process, thereby allowing manipulation
of the POI alone.\r\nIn optogenetics, naturally occurring photosensory domain
from plants, algae and bacteria are re-purposed and genetically fused to POIs.
Illumination with light of a specific wavelength triggers a conformational change
that can mediate PPIs, such as dimerization or oligomerization. By using light
as a trigger, these tools can be activated with high spatial and temporal precision,
on subcellular and millisecond scales. Chemogenetic tools consist of protein domains
that recognize and bind small molecules. By genetic fusion to POIs, these domains
can mediate PPIs upon addition of their specific ligands, which are often synthetically
designed to provide highly specific interactions and exhibit good bioavailability.\r\nMost
optogenetic tools to mediate PPIs are based on well-studied photoreceptors responding
to red, blue or near-UV light, leaving a striking gap in the green band of the
visible light spectrum. Among both optogenetic and chemogenetic tools, there is
an abundance of methods to induce PPIs, but tools to disrupt them require UV illumination,
rely on covalent linkage and subsequent enzymatic cleavage or initially result
in protein clustering of unknown stoichiometry.\r\nThis work describes how the
recently structurally and photochemically characterized green-light responsive
cobalamin-binding domains (CBDs) from bacterial transcription factors were re-purposed
to function as a green-light responsive optogenetic tool. In contrast to previously
engineered optogenetic tools, CBDs do not induce PPI, but rather confer a PPI
already upon expression, which can be rapidly disrupted by illumination. This
was employed to mimic inhibition of constitutive activity of a growth factor receptor,
and successfully implement for cell signalling in mammalian cells and in vivo
to rescue development in zebrafish. This work further describes the development
and application of a chemically induced de-dimerizer (CDD) based on a recently
identified and structurally described bacterial oxyreductase. CDD forms a dimer
upon expression in absence of its cofactor, the flavin derivative F420. Safety
and of domain expression and ligand exposure are demonstrated in vitro and in
vivo in zebrafish. The system is further applied to inhibit cell signalling output
from a chimeric receptor upon F420 treatment.\r\nCBDs and CDD expand the repertoire
of synthetic tools by providing novel mechanisms of mediating PPIs, and by recognizing
previously not utilized cues. In the future, they can readily be combined with
existing synthetic tools to functionally manipulate PPIs in vitro and in vivo."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Stephanie
full_name: Kainrath, Stephanie
id: 32CFBA64-F248-11E8-B48F-1D18A9856A87
last_name: Kainrath
citation:
ama: Kainrath S. Synthetic tools for optogenetic and chemogenetic inhibition of
cellular signals. 2020. doi:10.15479/AT:ISTA:7680
apa: Kainrath, S. (2020). Synthetic tools for optogenetic and chemogenetic inhibition
of cellular signals. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7680
chicago: Kainrath, Stephanie. “Synthetic Tools for Optogenetic and Chemogenetic
Inhibition of Cellular Signals.” Institute of Science and Technology Austria,
2020. https://doi.org/10.15479/AT:ISTA:7680.
ieee: S. Kainrath, “Synthetic tools for optogenetic and chemogenetic inhibition
of cellular signals,” Institute of Science and Technology Austria, 2020.
ista: Kainrath S. 2020. Synthetic tools for optogenetic and chemogenetic inhibition
of cellular signals. Institute of Science and Technology Austria.
mla: Kainrath, Stephanie. Synthetic Tools for Optogenetic and Chemogenetic Inhibition
of Cellular Signals. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:7680.
short: S. Kainrath, Synthetic Tools for Optogenetic and Chemogenetic Inhibition
of Cellular Signals, Institute of Science and Technology Austria, 2020.
date_created: 2020-04-24T16:00:51Z
date_published: 2020-04-24T00:00:00Z
date_updated: 2023-09-22T09:20:10Z
day: '24'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:7680
file:
- access_level: open_access
checksum: fb9a4468eb27be92690728e35c823796
content_type: application/pdf
creator: stgingl
date_created: 2020-04-28T11:19:21Z
date_updated: 2021-10-31T23:30:05Z
embargo: 2021-10-30
file_id: '7692'
file_name: Thesis_without-signatures_PDFA.pdf
file_size: 3268017
relation: main_file
- access_level: closed
checksum: f6c80ca97104a631a328cb79a2c53493
content_type: application/octet-stream
creator: stgingl
date_created: 2020-04-28T11:19:24Z
date_updated: 2021-10-31T23:30:05Z
embargo_to: open_access
file_id: '7693'
file_name: Thesis_without signatures.docx
file_size: 5167703
relation: source_file
file_date_updated: 2021-10-31T23:30:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: None
page: '98'
publication_identifier:
eissn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '1028'
relation: dissertation_contains
status: public
status: public
supervisor:
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
title: Synthetic tools for optogenetic and chemogenetic inhibition of cellular signals
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '8620'
abstract:
- lang: eng
text: "The development of the human brain occurs through a tightly regulated series
of dynamic and adaptive processes during prenatal and postnatal life. A disruption
of this strictly orchestrated series of events can lead to a number of neurodevelopmental
conditions, including Autism Spectrum Disorders (ASDs). ASDs are a very common,
etiologically and phenotypically heterogeneous group of disorders sharing the
core symptoms of social interaction and communication deficits and restrictive
and repetitive interests and behaviors. They are estimated to affect one in 59
individuals in the U.S. and, over the last three decades, mutations in more than
a hundred genetic loci have been convincingly linked to ASD pathogenesis. Yet,
for the vast majority of these ASD-risk genes their role during brain development
and precise molecular function still remain elusive.\r\nDe novo loss of function
mutations in the ubiquitin ligase-encoding gene Cullin 3 (CUL3) lead to ASD. In
the study described here, we used Cul3 mouse models to evaluate the consequences
of Cul3 mutations in vivo. Our results show that Cul3 heterozygous knockout mice
exhibit deficits in motor coordination as well as ASD-relevant social and cognitive
impairments. Cul3+/-, Cul3+/fl Emx1-Cre and Cul3fl/fl Emx1-Cre mutant brains display
cortical lamination abnormalities due to defective migration of post-mitotic excitatory
neurons, as well as reduced numbers of excitatory and inhibitory neurons. In line
with the observed abnormal cortical organization, Cul3 heterozygous deletion is
associated with decreased spontaneous excitatory and inhibitory activity in the
cortex. At the molecular level we show that Cul3 regulates cytoskeletal and adhesion
protein abundance in the mouse embryonic cortex. Abnormal regulation of cytoskeletal
proteins in Cul3 mutant neural cells results in atypical organization of the actin
mesh at the cell leading edge. Of note, heterozygous deletion of Cul3 in adult
mice does not induce the majority of the behavioral defects observed in constitutive
Cul3 haploinsufficient animals, pointing to a critical time-window for Cul3 deficiency.\r\nIn
conclusion, our data indicate that Cul3 plays a critical role in the regulation
of cytoskeletal proteins and neuronal migration. ASD-associated defects and behavioral
abnormalities are primarily due to dosage sensitive Cul3 functions at early brain
developmental stages."
acknowledged_ssus:
- _id: Bio
- _id: PreCl
acknowledgement: I would like to especially thank Armel Nicolas from the Proteomics
and Christoph Sommer from the Bioimaging Facilities for the data analysis, and to
thank the team of the Preclinical Facility, especially Sabina Deixler, Angela Schlerka,
Anita Lepold, Mihalea Mihai and Michael Schun for taking care of the mouse line
maintenance and their great support.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Jasmin
full_name: Morandell, Jasmin
id: 4739D480-F248-11E8-B48F-1D18A9856A87
last_name: Morandell
citation:
ama: Morandell J. Illuminating the role of Cul3 in autism spectrum disorder pathogenesis.
2020. doi:10.15479/AT:ISTA:8620
apa: Morandell, J. (2020). Illuminating the role of Cul3 in autism spectrum disorder
pathogenesis. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8620
chicago: Morandell, Jasmin. “Illuminating the Role of Cul3 in Autism Spectrum Disorder
Pathogenesis.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8620.
ieee: J. Morandell, “Illuminating the role of Cul3 in autism spectrum disorder pathogenesis,”
Institute of Science and Technology Austria, 2020.
ista: Morandell J. 2020. Illuminating the role of Cul3 in autism spectrum disorder
pathogenesis. Institute of Science and Technology Austria.
mla: Morandell, Jasmin. Illuminating the Role of Cul3 in Autism Spectrum Disorder
Pathogenesis. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8620.
short: J. Morandell, Illuminating the Role of Cul3 in Autism Spectrum Disorder Pathogenesis,
Institute of Science and Technology Austria, 2020.
date_created: 2020-10-07T14:53:13Z
date_published: 2020-10-12T00:00:00Z
date_updated: 2023-09-07T13:22:14Z
day: '12'
ddc:
- '610'
degree_awarded: PhD
department:
- _id: GaNo
doi: 10.15479/AT:ISTA:8620
file:
- access_level: open_access
checksum: 7ee83e42de3e5ce2fedb44dff472f75f
content_type: application/pdf
creator: jmorande
date_created: 2020-10-07T14:41:49Z
date_updated: 2021-10-16T22:30:04Z
embargo: 2021-10-15
file_id: '8621'
file_name: Jasmin_Morandell_Thesis-2020_final.pdf
file_size: 16155786
relation: main_file
- access_level: closed
checksum: 5e0464af453734210ce7aab7b4a92e3a
content_type: application/x-zip-compressed
creator: jmorande
date_created: 2020-10-07T14:45:07Z
date_updated: 2021-10-16T22:30:04Z
embargo_to: open_access
file_id: '8622'
file_name: Jasmin_Morandell_Thesis-2020_final.zip
file_size: 24344152
relation: source_file
file_date_updated: 2021-10-16T22:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '138'
project:
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
- _id: 05A0D778-7A3F-11EA-A408-12923DDC885E
grant_number: F07807
name: Neural stem cells in autism and epilepsy
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7800'
relation: part_of_dissertation
status: public
- id: '8131'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
title: Illuminating the role of Cul3 in autism spectrum disorder pathogenesis
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '8340'
abstract:
- lang: eng
text: Mitochondria are sites of oxidative phosphorylation in eukaryotic cells. Oxidative
phosphorylation operates by a chemiosmotic mechanism made possible by redox-driven
proton pumping machines which establish a proton motive force across the inner
mitochondrial membrane. This electrochemical proton gradient is used to drive
ATP synthesis, which powers the majority of cellular processes such as protein
synthesis, locomotion and signalling. In this thesis I investigate the structures
and molecular mechanisms of two inner mitochondrial proton pumping enzymes, respiratory
complex I and transhydrogenase. I present the first high-resolution structure
of the full transhydrogenase from any species, and a significantly improved structure
of complex I. Improving the resolution from 3.3 Å available previously to up to
2.3 Å in this thesis allowed us to model bound water molecules, crucial in the
proton pumping mechanism. For both enzymes, up to five cryo-EM datasets with different
substrates and inhibitors bound were solved to delineate the catalytic cycle and
understand the proton pumping mechanism. In transhydrogenase, the proton channel
is gated by reversible detachment of the NADP(H)-binding domain which opens the
proton channel to the opposite sites of the membrane. In complex I, the proton
channels are gated by reversible protonation of key glutamate and lysine residues
and breaking of the water wire connecting the proton pumps with the quinone reduction
site. The tight coupling between the redox and the proton pumping reactions in
transhydrogenase is achieved by controlling the NADP(H) exchange which can only
happen when the NADP(H)-binding domain interacts with the membrane domain. In
complex I, coupling is achieved by cycling of the whole complex between the closed
state, in which quinone can get reduced, and the open state, in which NADH can
induce quinol ejection from the binding pocket. On the basis of these results
I propose detailed mechanisms for catalytic cycles of transhydrogenase and complex
I that are consistent with a large amount of previous work. In both enzymes, conformational
and electrostatic mechanisms contribute to the overall catalytic process. Results
presented here could be used for better understanding of the human pathologies
arising from deficiencies of complex I or transhydrogenase and could be used to
develop novel therapies.
acknowledged_ssus:
- _id: EM-Fac
acknowledgement: 'I acknowledge the support of IST facilities, especially the Electron
Miscroscopy facility for providing training and resources. Special thanks also go
to cryo-EM specialists who helped me to collect the data present here: Dr Valentin
Hodirnau (IST Austria), Dr Tom Heuser (IMBA, Vienna), Dr Rebecca Thompson (Uni.
of Leeds) and Dr Jirka Nováček (CEITEC). This work has been supported by iNEXT,
project number 653706, funded by the Horizon 2020 programme of the European Union.
This project has received funding from the European Union’s Horizon 2020 research
and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 665385.'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Domen
full_name: Kampjut, Domen
id: 37233050-F248-11E8-B48F-1D18A9856A87
last_name: Kampjut
citation:
ama: Kampjut D. Molecular mechanisms of mitochondrial redox-coupled proton pumping
enzymes. 2020. doi:10.15479/AT:ISTA:8340
apa: Kampjut, D. (2020). Molecular mechanisms of mitochondrial redox-coupled
proton pumping enzymes. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8340
chicago: Kampjut, Domen. “Molecular Mechanisms of Mitochondrial Redox-Coupled Proton
Pumping Enzymes.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8340.
ieee: D. Kampjut, “Molecular mechanisms of mitochondrial redox-coupled proton pumping
enzymes,” Institute of Science and Technology Austria, 2020.
ista: Kampjut D. 2020. Molecular mechanisms of mitochondrial redox-coupled proton
pumping enzymes. Institute of Science and Technology Austria.
mla: Kampjut, Domen. Molecular Mechanisms of Mitochondrial Redox-Coupled Proton
Pumping Enzymes. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8340.
short: D. Kampjut, Molecular Mechanisms of Mitochondrial Redox-Coupled Proton Pumping
Enzymes, Institute of Science and Technology Austria, 2020.
date_created: 2020-09-07T18:42:23Z
date_published: 2020-09-09T00:00:00Z
date_updated: 2023-09-07T13:26:17Z
day: '09'
ddc:
- '572'
degree_awarded: PhD
department:
- _id: LeSa
doi: 10.15479/AT:ISTA:8340
ec_funded: 1
file:
- access_level: closed
checksum: dd270baf82121eb4472ad19d77bf227c
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: dkampjut
date_created: 2020-09-08T13:32:06Z
date_updated: 2021-09-11T22:30:04Z
embargo_to: open_access
file_id: '8345'
file_name: ThesisFull20200908.docx
file_size: 166146359
relation: source_file
- access_level: open_access
checksum: 82fce6f95ffa47ecc4ebca67ea2cc38c
content_type: application/pdf
creator: dernst
date_created: 2020-09-14T15:02:20Z
date_updated: 2021-09-11T22:30:04Z
embargo: 2021-09-10
file_id: '8393'
file_name: 2020_Thesis_Kampjut.pdf
file_size: 13873769
relation: main_file
file_date_updated: 2021-09-11T22:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: None
page: '242'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-008-4
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '6848'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
title: Molecular mechanisms of mitochondrial redox-coupled proton pumping enzymes
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '7800'
abstract:
- lang: eng
text: De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3
(CUL3) lead to autism spectrum disorder (ASD). Here, we used Cul3 mouse models
to evaluate the consequences of Cul3 mutations in vivo. Our results show that
Cul3 haploinsufficient mice exhibit deficits in motor coordination as well as
ASD-relevant social and cognitive impairments. Cul3 mutant brain displays cortical
lamination abnormalities due to defective neuronal migration and reduced numbers
of excitatory and inhibitory neurons. In line with the observed abnormal columnar
organization, Cul3 haploinsufficiency is associated with decreased spontaneous
excitatory and inhibitory activity in the cortex. At the molecular level, employing
a quantitative proteomic approach, we show that Cul3 regulates cytoskeletal and
adhesion protein abundance in mouse embryos. Abnormal regulation of cytoskeletal
proteins in Cul3 mutant neuronal cells results in atypical organization of the
actin mesh at the cell leading edge, likely causing the observed migration deficits.
In contrast to these important functions early in development, Cul3 deficiency
appears less relevant at adult stages. In fact, induction of Cul3 haploinsufficiency
in adult mice does not result in the behavioral defects observed in constitutive
Cul3 haploinsufficient animals. Taken together, our data indicate that Cul3 has
a critical role in the regulation of cytoskeletal proteins and neuronal migration
and that ASD-associated defects and behavioral abnormalities are primarily due
to Cul3 functions at early developmental stages.
acknowledged_ssus:
- _id: PreCl
article_processing_charge: No
author:
- first_name: Jasmin
full_name: Morandell, Jasmin
id: 4739D480-F248-11E8-B48F-1D18A9856A87
last_name: Morandell
- first_name: Lena A
full_name: Schwarz, Lena A
id: 29A8453C-F248-11E8-B48F-1D18A9856A87
last_name: Schwarz
- first_name: Bernadette
full_name: Basilico, Bernadette
id: 36035796-5ACA-11E9-A75E-7AF2E5697425
last_name: Basilico
orcid: 0000-0003-1843-3173
- first_name: Saren
full_name: Tasciyan, Saren
id: 4323B49C-F248-11E8-B48F-1D18A9856A87
last_name: Tasciyan
orcid: 0000-0003-1671-393X
- first_name: Armel
full_name: Nicolas, Armel
id: 2A103192-F248-11E8-B48F-1D18A9856A87
last_name: Nicolas
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Caroline
full_name: Kreuzinger, Caroline
id: 382077BA-F248-11E8-B48F-1D18A9856A87
last_name: Kreuzinger
- first_name: Lisa
full_name: Knaus, Lisa
id: 3B2ABCF4-F248-11E8-B48F-1D18A9856A87
last_name: Knaus
- first_name: Zoe
full_name: Dobler, Zoe
id: D23090A2-9057-11EA-883A-A8396FC7A38F
last_name: Dobler
- first_name: Emanuele
full_name: Cacci, Emanuele
last_name: Cacci
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Morandell J, Schwarz LA, Basilico B, et al. Cul3 regulates cytoskeleton protein
homeostasis and cell migration during a critical window of brain development.
bioRxiv. doi:10.1101/2020.01.10.902064
apa: Morandell, J., Schwarz, L. A., Basilico, B., Tasciyan, S., Nicolas, A., Sommer,
C. M., … Novarino, G. (n.d.). Cul3 regulates cytoskeleton protein homeostasis
and cell migration during a critical window of brain development. bioRxiv.
Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.01.10.902064
chicago: Morandell, Jasmin, Lena A Schwarz, Bernadette Basilico, Saren Tasciyan,
Armel Nicolas, Christoph M Sommer, Caroline Kreuzinger, et al. “Cul3 Regulates
Cytoskeleton Protein Homeostasis and Cell Migration during a Critical Window of
Brain Development.” BioRxiv. Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2020.01.10.902064 .
ieee: J. Morandell et al., “Cul3 regulates cytoskeleton protein homeostasis
and cell migration during a critical window of brain development,” bioRxiv.
Cold Spring Harbor Laboratory.
ista: Morandell J, Schwarz LA, Basilico B, Tasciyan S, Nicolas A, Sommer CM, Kreuzinger
C, Knaus L, Dobler Z, Cacci E, Danzl JG, Novarino G. Cul3 regulates cytoskeleton
protein homeostasis and cell migration during a critical window of brain development.
bioRxiv, 10.1101/2020.01.10.902064
.
mla: Morandell, Jasmin, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis
and Cell Migration during a Critical Window of Brain Development.” BioRxiv,
Cold Spring Harbor Laboratory, doi:10.1101/2020.01.10.902064 .
short: J. Morandell, L.A. Schwarz, B. Basilico, S. Tasciyan, A. Nicolas, C.M. Sommer,
C. Kreuzinger, L. Knaus, Z. Dobler, E. Cacci, J.G. Danzl, G. Novarino, BioRxiv
(n.d.).
date_created: 2020-05-05T14:31:33Z
date_published: 2020-01-11T00:00:00Z
date_updated: 2024-03-27T23:30:14Z
day: '11'
ddc:
- '570'
department:
- _id: JoDa
- _id: GaNo
- _id: LifeSc
doi: '10.1101/2020.01.10.902064 '
file:
- access_level: open_access
checksum: c6799ab5daba80efe8e2ed63c15f8c81
content_type: application/pdf
creator: rsix
date_created: 2020-05-05T14:31:19Z
date_updated: 2020-07-14T12:48:03Z
file_id: '7801'
file_name: 2020.01.10.902064v1.full.pdf
file_size: 2931370
relation: main_file
file_date_updated: 2020-07-14T12:48:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Preprint
project:
- _id: 265CB4D0-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03600
name: Optical control of synaptic function via adhesion molecules
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '9429'
relation: later_version
status: public
- id: '8620'
relation: dissertation_contains
status: public
status: public
title: Cul3 regulates cytoskeleton protein homeostasis and cell migration during a
critical window of brain development
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8131'
abstract:
- lang: eng
text: The possibility to generate construct valid animal models enabled the development
and testing of therapeutic strategies targeting the core features of autism spectrum
disorders (ASDs). At the same time, these studies highlighted the necessity of
identifying sensitive developmental time windows for successful therapeutic interventions.
Animal and human studies also uncovered the possibility to stratify the variety
of ASDs in molecularly distinct subgroups, potentially facilitating effective
treatment design. Here, we focus on the molecular pathways emerging as commonly
affected by mutations in diverse ASD-risk genes, on their role during critical
windows of brain development and the potential treatments targeting these biological
processes.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Bernadette
full_name: Basilico, Bernadette
id: 36035796-5ACA-11E9-A75E-7AF2E5697425
last_name: Basilico
orcid: 0000-0003-1843-3173
- first_name: Jasmin
full_name: Morandell, Jasmin
id: 4739D480-F248-11E8-B48F-1D18A9856A87
last_name: Morandell
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Basilico B, Morandell J, Novarino G. Molecular mechanisms for targeted ASD
treatments. Current Opinion in Genetics and Development. 2020;65(12):126-137.
doi:10.1016/j.gde.2020.06.004
apa: Basilico, B., Morandell, J., & Novarino, G. (2020). Molecular mechanisms
for targeted ASD treatments. Current Opinion in Genetics and Development.
Elsevier. https://doi.org/10.1016/j.gde.2020.06.004
chicago: Basilico, Bernadette, Jasmin Morandell, and Gaia Novarino. “Molecular Mechanisms
for Targeted ASD Treatments.” Current Opinion in Genetics and Development.
Elsevier, 2020. https://doi.org/10.1016/j.gde.2020.06.004.
ieee: B. Basilico, J. Morandell, and G. Novarino, “Molecular mechanisms for targeted
ASD treatments,” Current Opinion in Genetics and Development, vol. 65,
no. 12. Elsevier, pp. 126–137, 2020.
ista: Basilico B, Morandell J, Novarino G. 2020. Molecular mechanisms for targeted
ASD treatments. Current Opinion in Genetics and Development. 65(12), 126–137.
mla: Basilico, Bernadette, et al. “Molecular Mechanisms for Targeted ASD Treatments.”
Current Opinion in Genetics and Development, vol. 65, no. 12, Elsevier,
2020, pp. 126–37, doi:10.1016/j.gde.2020.06.004.
short: B. Basilico, J. Morandell, G. Novarino, Current Opinion in Genetics and Development
65 (2020) 126–137.
date_created: 2020-07-19T22:00:58Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-03-27T23:30:14Z
day: '01'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.1016/j.gde.2020.06.004
ec_funded: 1
external_id:
isi:
- '000598918900019'
pmid:
- '32659636'
file:
- access_level: open_access
content_type: application/pdf
creator: dernst
date_created: 2020-07-22T06:47:45Z
date_updated: 2020-07-22T06:47:45Z
file_id: '8146'
file_name: 2020_CurrentOpGenetics_Basilico.pdf
file_size: 1381545
relation: main_file
success: 1
file_date_updated: 2020-07-22T06:47:45Z
has_accepted_license: '1'
intvolume: ' 65'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 126-137
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
- _id: 05A0D778-7A3F-11EA-A408-12923DDC885E
grant_number: F07807
name: Neural stem cells in autism and epilepsy
publication: Current Opinion in Genetics and Development
publication_identifier:
eissn:
- '18790380'
issn:
- 0959437X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '8620'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Molecular mechanisms for targeted ASD treatments
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 65
year: '2020'
...
---
_id: '8434'
abstract:
- lang: eng
text: 'Efficient migration on adhesive surfaces involves the protrusion of lamellipodial
actin networks and their subsequent stabilization by nascent adhesions. The actin-binding
protein lamellipodin (Lpd) is thought to play a critical role in lamellipodium
protrusion, by delivering Ena/VASP proteins onto the growing plus ends of actin
filaments and by interacting with the WAVE regulatory complex, an activator of
the Arp2/3 complex, at the leading edge. Using B16-F1 melanoma cell lines, we
demonstrate that genetic ablation of Lpd compromises protrusion efficiency and
coincident cell migration without altering essential parameters of lamellipodia,
including their maximal rate of forward advancement and actin polymerization.
We also confirmed lamellipodia and migration phenotypes with CRISPR/Cas9-mediated
Lpd knockout Rat2 fibroblasts, excluding cell type-specific effects. Moreover,
computer-aided analysis of cell-edge morphodynamics on B16-F1 cell lamellipodia
revealed that loss of Lpd correlates with reduced temporal protrusion maintenance
as a prerequisite of nascent adhesion formation. We conclude that Lpd optimizes
protrusion and nascent adhesion formation by counteracting frequent, chaotic retraction
and membrane ruffling.This article has an associated First Person interview with
the first author of the paper. '
acknowledgement: This work was supported in part by Deutsche Forschungsgemeinschaft
(DFG)[GRK2223/1, RO2414/5-1 (to K.R.), FA350/11-1 (to M.F.) and FA330/11-1 (to J.F.)],as
well as by intramural funding from the Helmholtz Association (to T.E.B.S. andK.R.).
G.D. was additionally funded by the Austrian Science Fund (FWF) LiseMeitner Program
[M-2495]. A.C.H. and M.W. are supported by the Francis CrickInstitute, which receives
its core funding from Cancer Research UK [FC001209], theMedical Research Council
[FC001209] and the Wellcome Trust [FC001209]. M.K. issupported by the Biotechnology
and Biological Sciences Research Council [BB/F011431/1, BB/J000590/1, BB/N000226/1].
Deposited in PMC for release after 6months.
article_number: jcs239020
article_processing_charge: No
article_type: original
author:
- first_name: Georgi A
full_name: Dimchev, Georgi A
id: 38C393BE-F248-11E8-B48F-1D18A9856A87
last_name: Dimchev
orcid: 0000-0001-8370-6161
- first_name: Behnam
full_name: Amiri, Behnam
last_name: Amiri
- first_name: Ashley C.
full_name: Humphries, Ashley C.
last_name: Humphries
- first_name: Matthias
full_name: Schaks, Matthias
last_name: Schaks
- first_name: Vanessa
full_name: Dimchev, Vanessa
last_name: Dimchev
- first_name: Theresia E. B.
full_name: Stradal, Theresia E. B.
last_name: Stradal
- first_name: Jan
full_name: Faix, Jan
last_name: Faix
- first_name: Matthias
full_name: Krause, Matthias
last_name: Krause
- first_name: Michael
full_name: Way, Michael
last_name: Way
- first_name: Martin
full_name: Falcke, Martin
last_name: Falcke
- first_name: Klemens
full_name: Rottner, Klemens
last_name: Rottner
citation:
ama: Dimchev GA, Amiri B, Humphries AC, et al. Lamellipodin tunes cell migration
by stabilizing protrusions and promoting adhesion formation. Journal of Cell
Science. 2020;133(7). doi:10.1242/jcs.239020
apa: Dimchev, G. A., Amiri, B., Humphries, A. C., Schaks, M., Dimchev, V., Stradal,
T. E. B., … Rottner, K. (2020). Lamellipodin tunes cell migration by stabilizing
protrusions and promoting adhesion formation. Journal of Cell Science.
The Company of Biologists. https://doi.org/10.1242/jcs.239020
chicago: Dimchev, Georgi A, Behnam Amiri, Ashley C. Humphries, Matthias Schaks,
Vanessa Dimchev, Theresia E. B. Stradal, Jan Faix, et al. “Lamellipodin Tunes
Cell Migration by Stabilizing Protrusions and Promoting Adhesion Formation.” Journal
of Cell Science. The Company of Biologists, 2020. https://doi.org/10.1242/jcs.239020.
ieee: G. A. Dimchev et al., “Lamellipodin tunes cell migration by stabilizing
protrusions and promoting adhesion formation,” Journal of Cell Science,
vol. 133, no. 7. The Company of Biologists, 2020.
ista: Dimchev GA, Amiri B, Humphries AC, Schaks M, Dimchev V, Stradal TEB, Faix
J, Krause M, Way M, Falcke M, Rottner K. 2020. Lamellipodin tunes cell migration
by stabilizing protrusions and promoting adhesion formation. Journal of Cell Science.
133(7), jcs239020.
mla: Dimchev, Georgi A., et al. “Lamellipodin Tunes Cell Migration by Stabilizing
Protrusions and Promoting Adhesion Formation.” Journal of Cell Science,
vol. 133, no. 7, jcs239020, The Company of Biologists, 2020, doi:10.1242/jcs.239020.
short: G.A. Dimchev, B. Amiri, A.C. Humphries, M. Schaks, V. Dimchev, T.E.B. Stradal,
J. Faix, M. Krause, M. Way, M. Falcke, K. Rottner, Journal of Cell Science 133
(2020).
date_created: 2020-09-17T14:00:33Z
date_published: 2020-04-09T00:00:00Z
date_updated: 2023-09-05T15:41:48Z
day: '09'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1242/jcs.239020
external_id:
isi:
- '000534387800005'
pmid:
- ' 32094266'
file:
- access_level: open_access
checksum: ba917e551acc4ece2884b751434df9ae
content_type: application/pdf
creator: dernst
date_created: 2020-09-17T14:07:51Z
date_updated: 2020-10-11T22:30:02Z
embargo: 2020-10-10
file_id: '8435'
file_name: 2020_JournalCellScience_Dimchev.pdf
file_size: 13493302
relation: main_file
file_date_updated: 2020-10-11T22:30:02Z
has_accepted_license: '1'
intvolume: ' 133'
isi: 1
issue: '7'
keyword:
- Cell Biology
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2674F658-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02495
name: Protein structure and function in filopodia across scales
publication: Journal of Cell Science
publication_identifier:
eissn:
- 1477-9137
issn:
- 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
status: public
title: Lamellipodin tunes cell migration by stabilizing protrusions and promoting
adhesion formation
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 133
year: '2020'
...
---
_id: '7889'
abstract:
- lang: eng
text: Autoluminescent plants engineered to express a bacterial bioluminescence gene
cluster in plastids have not been widely adopted because of low light output.
We engineered tobacco plants with a fungal bioluminescence system that converts
caffeic acid (present in all plants) into luciferin and report self-sustained
luminescence that is visible to the naked eye. Our findings could underpin development
of a suite of imaging tools for plants.
acknowledgement: "This study was designed, performed and funded by Planta LLC. We
thank K. Wood for assisting in manuscript development. Planta acknowledges support
from the Skolkovo Innovation Centre. We thank D. Bolotin and the Milaboratory (milaboratory.com)
for access to computing and storage infrastructure. We thank S. Shakhov for providing\r\nphotography
equipment. The Synthetic Biology Group is funded by the MRC London Institute of
Medical Sciences (UKRI MC-A658-5QEA0, K.S.S.). K.S.S. is supported by an Imperial
College Research Fellowship. Experiments were partially carried out using equipment
provided by the Institute of Bioorganic Chemistry of the Russian Academy\r\nof Sciences
Сore Facility (CKP IBCH; supported by the Russian Ministry of Education and Science
Grant RFMEFI62117X0018). The F.A.K. lab is supported by ERC grant agreement 771209—CharFL.
This project received funding from the European Union’s Horizon 2020 Research and
Innovation Programme under Marie Skłodowska-Curie\r\nGrant Agreement 665385. K.S.S.
acknowledges support by President’s Grant 075-15-2019-411. Design and assembly of
some of the plasmids was supported by Russian Science Foundation grant 19-74-10102.
Imaging experiments were partially supported by Russian Science Foundation grant
17-14-01169p. LC-MS/MS analyses of extracts were\r\nsupported by Russian Science
Foundation grant 16-14-00052p. Design and assembly of plasmids was partially supported
by grant 075-15-2019-1789 from the Ministry of Science and Higher Education of the
Russian Federation allocated to the Center for Precision Genome Editing and Genetic
Technologies for Biomedicine. The authors\r\nwould like to acknowledge the work
of Genomics Core Facility of the Skolkovo Institute of Science and Technology, which
performed the sequencing and bioinformatic analysis."
article_processing_charge: No
article_type: original
author:
- first_name: Tatiana
full_name: Mitiouchkina, Tatiana
last_name: Mitiouchkina
- first_name: Alexander S.
full_name: Mishin, Alexander S.
last_name: Mishin
- first_name: Louisa
full_name: Gonzalez Somermeyer, Louisa
id: 4720D23C-F248-11E8-B48F-1D18A9856A87
last_name: Gonzalez Somermeyer
orcid: 0000-0001-9139-5383
- first_name: Nadezhda M.
full_name: Markina, Nadezhda M.
last_name: Markina
- first_name: Tatiana V.
full_name: Chepurnyh, Tatiana V.
last_name: Chepurnyh
- first_name: Elena B.
full_name: Guglya, Elena B.
last_name: Guglya
- first_name: Tatiana A.
full_name: Karataeva, Tatiana A.
last_name: Karataeva
- first_name: Kseniia A.
full_name: Palkina, Kseniia A.
last_name: Palkina
- first_name: Ekaterina S.
full_name: Shakhova, Ekaterina S.
last_name: Shakhova
- first_name: Liliia I.
full_name: Fakhranurova, Liliia I.
last_name: Fakhranurova
- first_name: Sofia V.
full_name: Chekova, Sofia V.
last_name: Chekova
- first_name: Aleksandra S.
full_name: Tsarkova, Aleksandra S.
last_name: Tsarkova
- first_name: Yaroslav V.
full_name: Golubev, Yaroslav V.
last_name: Golubev
- first_name: Vadim V.
full_name: Negrebetsky, Vadim V.
last_name: Negrebetsky
- first_name: Sergey A.
full_name: Dolgushin, Sergey A.
last_name: Dolgushin
- first_name: Pavel V.
full_name: Shalaev, Pavel V.
last_name: Shalaev
- first_name: Dmitry
full_name: Shlykov, Dmitry
last_name: Shlykov
- first_name: Olesya A.
full_name: Melnik, Olesya A.
last_name: Melnik
- first_name: Victoria O.
full_name: Shipunova, Victoria O.
last_name: Shipunova
- first_name: Sergey M.
full_name: Deyev, Sergey M.
last_name: Deyev
- first_name: Andrey I.
full_name: Bubyrev, Andrey I.
last_name: Bubyrev
- first_name: Alexander S.
full_name: Pushin, Alexander S.
last_name: Pushin
- first_name: Vladimir V.
full_name: Choob, Vladimir V.
last_name: Choob
- first_name: Sergey V.
full_name: Dolgov, Sergey V.
last_name: Dolgov
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Ilia V.
full_name: Yampolsky, Ilia V.
last_name: Yampolsky
- first_name: Karen S.
full_name: Sarkisyan, Karen S.
last_name: Sarkisyan
citation:
ama: Mitiouchkina T, Mishin AS, Gonzalez Somermeyer L, et al. Plants with genetically
encoded autoluminescence. Nature Biotechnology. 2020;38:944-946. doi:10.1038/s41587-020-0500-9
apa: Mitiouchkina, T., Mishin, A. S., Gonzalez Somermeyer, L., Markina, N. M., Chepurnyh,
T. V., Guglya, E. B., … Sarkisyan, K. S. (2020). Plants with genetically encoded
autoluminescence. Nature Biotechnology. Springer Nature. https://doi.org/10.1038/s41587-020-0500-9
chicago: Mitiouchkina, Tatiana, Alexander S. Mishin, Louisa Gonzalez Somermeyer,
Nadezhda M. Markina, Tatiana V. Chepurnyh, Elena B. Guglya, Tatiana A. Karataeva,
et al. “Plants with Genetically Encoded Autoluminescence.” Nature Biotechnology.
Springer Nature, 2020. https://doi.org/10.1038/s41587-020-0500-9.
ieee: T. Mitiouchkina et al., “Plants with genetically encoded autoluminescence,”
Nature Biotechnology, vol. 38. Springer Nature, pp. 944–946, 2020.
ista: Mitiouchkina T, Mishin AS, Gonzalez Somermeyer L, Markina NM, Chepurnyh TV,
Guglya EB, Karataeva TA, Palkina KA, Shakhova ES, Fakhranurova LI, Chekova SV,
Tsarkova AS, Golubev YV, Negrebetsky VV, Dolgushin SA, Shalaev PV, Shlykov D,
Melnik OA, Shipunova VO, Deyev SM, Bubyrev AI, Pushin AS, Choob VV, Dolgov SV,
Kondrashov F, Yampolsky IV, Sarkisyan KS. 2020. Plants with genetically encoded
autoluminescence. Nature Biotechnology. 38, 944–946.
mla: Mitiouchkina, Tatiana, et al. “Plants with Genetically Encoded Autoluminescence.”
Nature Biotechnology, vol. 38, Springer Nature, 2020, pp. 944–46, doi:10.1038/s41587-020-0500-9.
short: T. Mitiouchkina, A.S. Mishin, L. Gonzalez Somermeyer, N.M. Markina, T.V.
Chepurnyh, E.B. Guglya, T.A. Karataeva, K.A. Palkina, E.S. Shakhova, L.I. Fakhranurova,
S.V. Chekova, A.S. Tsarkova, Y.V. Golubev, V.V. Negrebetsky, S.A. Dolgushin, P.V.
Shalaev, D. Shlykov, O.A. Melnik, V.O. Shipunova, S.M. Deyev, A.I. Bubyrev, A.S.
Pushin, V.V. Choob, S.V. Dolgov, F. Kondrashov, I.V. Yampolsky, K.S. Sarkisyan,
Nature Biotechnology 38 (2020) 944–946.
date_created: 2020-05-25T15:02:00Z
date_published: 2020-04-27T00:00:00Z
date_updated: 2023-09-05T15:30:34Z
day: '27'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1038/s41587-020-0500-9
ec_funded: 1
external_id:
isi:
- '000529298800003'
pmid:
- '32341562'
file:
- access_level: open_access
checksum: 1b30467500ec6277229a875b06e196d0
content_type: application/pdf
creator: dernst
date_created: 2020-08-28T08:57:07Z
date_updated: 2021-03-02T23:30:03Z
embargo: 2021-03-01
file_id: '8316'
file_name: 2020_NatureBiotech_Mitiouchkina.pdf
file_size: 1180086
relation: main_file
file_date_updated: 2021-03-02T23:30:03Z
has_accepted_license: '1'
intvolume: ' 38'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Submitted Version
page: 944-946
pmid: 1
project:
- _id: 26580278-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771209'
name: Characterizing the fitness landscape on population and global scales
publication: Nature Biotechnology
publication_identifier:
eissn:
- 1546-1696
issn:
- 1087-0156
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41587-020-0578-0
scopus_import: '1'
status: public
title: Plants with genetically encoded autoluminescence
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 38
year: '2020'
...
---
_id: '9750'
abstract:
- lang: eng
text: Tension of the actomyosin cell cortex plays a key role in determining cell-cell
contact growth and size. The level of cortical tension outside of the cell-cell
contact, when pulling at the contact edge, scales with the total size to which
a cell-cell contact can grow1,2. Here we show in zebrafish primary germ layer
progenitor cells that this monotonic relationship only applies to a narrow range
of cortical tension increase, and that above a critical threshold, contact size
inversely scales with cortical tension. This switch from cortical tension increasing
to decreasing progenitor cell-cell contact size is caused by cortical tension
promoting E-cadherin anchoring to the actomyosin cytoskeleton, thereby increasing
clustering and stability of E-cadherin at the contact. Once tension-mediated E-cadherin
stabilization at the contact exceeds a critical threshold level, the rate by which
the contact expands in response to pulling forces from the cortex sharply drops,
leading to smaller contacts at physiologically relevant timescales of contact
formation. Thus, the activity of cortical tension in expanding cell-cell contact
size is limited by tension stabilizing E-cadherin-actin complexes at the contact.
acknowledged_ssus:
- _id: Bio
- _id: EM-Fac
- _id: SSU
acknowledgement: We would like to thank Edouard Hannezo for discussions, Shayan Shami
Pour and Daniel Capek for help with data analysis, Vanessa Barone and other members
of the Heisenberg laboratory for thoughtful discussions and comments on the manuscript.
We also thank Jack Merrin for preparing the microwells, and the Scientific Service
Units at IST Austria, specifically Bioimaging and Electron Microscopy, and the Zebrafish
Facility for continuous support. We acknowledge Hitoshi Morita for the kind gift
of VinculinB-GFP plasmid. This research was supported by an ERC Advanced Grant (MECSPEC)
to C.-P.H, EMBO Long Term grant (ALTF 187-2013) to M.S and IST Fellow Marie-Curie
COFUND No. P_IST_EU01 to J.S.
article_processing_charge: No
author:
- first_name: Jana
full_name: Slovakova, Jana
id: 30F3F2F0-F248-11E8-B48F-1D18A9856A87
last_name: Slovakova
- first_name: Mateusz K
full_name: Sikora, Mateusz K
id: 2F74BCDE-F248-11E8-B48F-1D18A9856A87
last_name: Sikora
- first_name: Silvia
full_name: Caballero Mancebo, Silvia
id: 2F1E1758-F248-11E8-B48F-1D18A9856A87
last_name: Caballero Mancebo
orcid: 0000-0002-5223-3346
- first_name: Gabriel
full_name: Krens, Gabriel
id: 2B819732-F248-11E8-B48F-1D18A9856A87
last_name: Krens
orcid: 0000-0003-4761-5996
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Karla
full_name: Huljev, Karla
id: 44C6F6A6-F248-11E8-B48F-1D18A9856A87
last_name: Huljev
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Slovakova J, Sikora MK, Caballero Mancebo S, et al. Tension-dependent stabilization
of E-cadherin limits cell-cell contact expansion. bioRxiv. 2020. doi:10.1101/2020.11.20.391284
apa: Slovakova, J., Sikora, M. K., Caballero Mancebo, S., Krens, G., Kaufmann, W.,
Huljev, K., & Heisenberg, C.-P. J. (2020). Tension-dependent stabilization
of E-cadherin limits cell-cell contact expansion. bioRxiv. Cold Spring
Harbor Laboratory. https://doi.org/10.1101/2020.11.20.391284
chicago: Slovakova, Jana, Mateusz K Sikora, Silvia Caballero Mancebo, Gabriel Krens,
Walter Kaufmann, Karla Huljev, and Carl-Philipp J Heisenberg. “Tension-Dependent
Stabilization of E-Cadherin Limits Cell-Cell Contact Expansion.” BioRxiv.
Cold Spring Harbor Laboratory, 2020. https://doi.org/10.1101/2020.11.20.391284.
ieee: J. Slovakova et al., “Tension-dependent stabilization of E-cadherin
limits cell-cell contact expansion,” bioRxiv. Cold Spring Harbor Laboratory,
2020.
ista: Slovakova J, Sikora MK, Caballero Mancebo S, Krens G, Kaufmann W, Huljev K,
Heisenberg C-PJ. 2020. Tension-dependent stabilization of E-cadherin limits cell-cell
contact expansion. bioRxiv, 10.1101/2020.11.20.391284.
mla: Slovakova, Jana, et al. “Tension-Dependent Stabilization of E-Cadherin Limits
Cell-Cell Contact Expansion.” BioRxiv, Cold Spring Harbor Laboratory, 2020,
doi:10.1101/2020.11.20.391284.
short: J. Slovakova, M.K. Sikora, S. Caballero Mancebo, G. Krens, W. Kaufmann, K.
Huljev, C.-P.J. Heisenberg, BioRxiv (2020).
date_created: 2021-07-29T11:29:50Z
date_published: 2020-11-20T00:00:00Z
date_updated: 2024-03-27T23:30:18Z
day: '20'
department:
- _id: CaHe
- _id: EM-Fac
- _id: Bio
doi: 10.1101/2020.11.20.391284
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.11.20.391284
month: '11'
oa: 1
oa_version: Preprint
page: '41'
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
- _id: 2521E28E-B435-11E9-9278-68D0E5697425
grant_number: 187-2013
name: Modulation of adhesion function in cell-cell contact formation by cortical
tension
publication: bioRxiv
publication_status: published
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '10766'
relation: later_version
status: public
- id: '9623'
relation: dissertation_contains
status: public
status: public
title: Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2020'
...
---
_id: '7885'
abstract:
- lang: eng
text: Eukaryotic cells migrate by coupling the intracellular force of the actin
cytoskeleton to the environment. While force coupling is usually mediated by transmembrane
adhesion receptors, especially those of the integrin family, amoeboid cells such
as leukocytes can migrate extremely fast despite very low adhesive forces1. Here
we show that leukocytes cannot only migrate under low adhesion but can also transmit
forces in the complete absence of transmembrane force coupling. When confined
within three-dimensional environments, they use the topographical features of
the substrate to propel themselves. Here the retrograde flow of the actin cytoskeleton
follows the texture of the substrate, creating retrograde shear forces that are
sufficient to drive the cell body forwards. Notably, adhesion-dependent and adhesion-independent
migration are not mutually exclusive, but rather are variants of the same principle
of coupling retrograde actin flow to the environment and thus can potentially
operate interchangeably and simultaneously. As adhesion-free migration is independent
of the chemical composition of the environment, it renders cells completely autonomous
in their locomotive behaviour.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: M-Shop
acknowledgement: We thank A. Leithner and J. Renkawitz for discussion and critical
reading of the manuscript; J. Schwarz and M. Mehling for establishing the microfluidic
setups; the Bioimaging Facility of IST Austria for excellent support, as well as
the Life Science Facility and the Miba Machine Shop of IST Austria; and F. N. Arslan,
L. E. Burnett and L. Li for their work during their rotation in the IST PhD programme.
This work was supported by the European Research Council (ERC StG 281556 and CoG
724373) to M.S. and grants from the Austrian Science Fund (FWF P29911) and the WWTF
to M.S. M.H. was supported by the European Regional Development Fund Project (CZ.02.1.01/0.0/0.0/15_003/0000476).
F.G. received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie grant agreement no. 747687.
article_processing_charge: No
article_type: original
author:
- first_name: Anne
full_name: Reversat, Anne
id: 35B76592-F248-11E8-B48F-1D18A9856A87
last_name: Reversat
orcid: 0000-0003-0666-8928
- first_name: Florian R
full_name: Gärtner, Florian R
id: 397A88EE-F248-11E8-B48F-1D18A9856A87
last_name: Gärtner
orcid: 0000-0001-6120-3723
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Julian A
full_name: Stopp, Julian A
id: 489E3F00-F248-11E8-B48F-1D18A9856A87
last_name: Stopp
- first_name: Saren
full_name: Tasciyan, Saren
id: 4323B49C-F248-11E8-B48F-1D18A9856A87
last_name: Tasciyan
orcid: 0000-0003-1671-393X
- first_name: Juan L
full_name: Aguilera Servin, Juan L
id: 2A67C376-F248-11E8-B48F-1D18A9856A87
last_name: Aguilera Servin
orcid: 0000-0002-2862-8372
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Miroslav
full_name: Hons, Miroslav
id: 4167FE56-F248-11E8-B48F-1D18A9856A87
last_name: Hons
orcid: 0000-0002-6625-3348
- first_name: Matthieu
full_name: Piel, Matthieu
last_name: Piel
- first_name: Andrew
full_name: Callan-Jones, Andrew
last_name: Callan-Jones
- first_name: Raphael
full_name: Voituriez, Raphael
last_name: Voituriez
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Reversat A, Gärtner FR, Merrin J, et al. Cellular locomotion using environmental
topography. Nature. 2020;582:582–585. doi:10.1038/s41586-020-2283-z
apa: Reversat, A., Gärtner, F. R., Merrin, J., Stopp, J. A., Tasciyan, S., Aguilera
Servin, J. L., … Sixt, M. K. (2020). Cellular locomotion using environmental topography.
Nature. Springer Nature. https://doi.org/10.1038/s41586-020-2283-z
chicago: Reversat, Anne, Florian R Gärtner, Jack Merrin, Julian A Stopp, Saren Tasciyan,
Juan L Aguilera Servin, Ingrid de Vries, et al. “Cellular Locomotion Using Environmental
Topography.” Nature. Springer Nature, 2020. https://doi.org/10.1038/s41586-020-2283-z.
ieee: A. Reversat et al., “Cellular locomotion using environmental topography,”
Nature, vol. 582. Springer Nature, pp. 582–585, 2020.
ista: Reversat A, Gärtner FR, Merrin J, Stopp JA, Tasciyan S, Aguilera Servin JL,
de Vries I, Hauschild R, Hons M, Piel M, Callan-Jones A, Voituriez R, Sixt MK.
2020. Cellular locomotion using environmental topography. Nature. 582, 582–585.
mla: Reversat, Anne, et al. “Cellular Locomotion Using Environmental Topography.”
Nature, vol. 582, Springer Nature, 2020, pp. 582–585, doi:10.1038/s41586-020-2283-z.
short: A. Reversat, F.R. Gärtner, J. Merrin, J.A. Stopp, S. Tasciyan, J.L. Aguilera
Servin, I. de Vries, R. Hauschild, M. Hons, M. Piel, A. Callan-Jones, R. Voituriez,
M.K. Sixt, Nature 582 (2020) 582–585.
date_created: 2020-05-24T22:01:01Z
date_published: 2020-06-25T00:00:00Z
date_updated: 2024-03-27T23:30:23Z
day: '25'
department:
- _id: NanoFab
- _id: Bio
- _id: MiSi
doi: 10.1038/s41586-020-2283-z
ec_funded: 1
external_id:
isi:
- '000532688300008'
intvolume: ' 582'
isi: 1
language:
- iso: eng
month: '06'
oa_version: None
page: 582–585
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281556'
name: Cytoskeletal force generation and force transduction of migrating leukocytes
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '724373'
name: Cellular navigation along spatial gradients
- _id: 26018E70-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29911
name: Mechanical adaptation of lamellipodial actin
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '747687'
name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
publication: Nature
publication_identifier:
eissn:
- '14764687'
issn:
- '00280836'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/off-road-mode-enables-mobile-cells-to-move-freely/
record:
- id: '14697'
relation: dissertation_contains
status: public
- id: '12401'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Cellular locomotion using environmental topography
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 582
year: '2020'
...
---
_id: '7426'
abstract:
- lang: eng
text: This paper presents a novel abstraction technique for analyzing Lyapunov and
asymptotic stability of polyhedral switched systems. A polyhedral switched system
is a hybrid system in which the continuous dynamics is specified by polyhedral
differential inclusions, the invariants and guards are specified by polyhedral
sets and the switching between the modes do not involve reset of variables. A
finite state weighted graph abstracting the polyhedral switched system is constructed
from a finite partition of the state–space, such that the satisfaction of certain
graph conditions, such as the absence of cycles with product of weights on the
edges greater than (or equal) to 1, implies the stability of the system. However,
the graph is in general conservative and hence, the violation of the graph conditions
does not imply instability. If the analysis fails to establish stability due to
the conservativeness in the approximation, a counterexample (cycle with product
of edge weights greater than or equal to 1) indicating a potential reason for
the failure is returned. Further, a more precise approximation of the switched
system can be constructed by considering a finer partition of the state–space
in the construction of the finite weighted graph. We present experimental results
on analyzing stability of switched systems using the above method.
article_number: '100856'
article_processing_charge: No
article_type: original
author:
- first_name: Miriam
full_name: Garcia Soto, Miriam
id: 4B3207F6-F248-11E8-B48F-1D18A9856A87
last_name: Garcia Soto
orcid: 0000−0003−2936−5719
- first_name: Pavithra
full_name: Prabhakar, Pavithra
last_name: Prabhakar
citation:
ama: 'Garcia Soto M, Prabhakar P. Abstraction based verification of stability of
polyhedral switched systems. Nonlinear Analysis: Hybrid Systems. 2020;36(5).
doi:10.1016/j.nahs.2020.100856'
apa: 'Garcia Soto, M., & Prabhakar, P. (2020). Abstraction based verification
of stability of polyhedral switched systems. Nonlinear Analysis: Hybrid Systems.
Elsevier. https://doi.org/10.1016/j.nahs.2020.100856'
chicago: 'Garcia Soto, Miriam, and Pavithra Prabhakar. “Abstraction Based Verification
of Stability of Polyhedral Switched Systems.” Nonlinear Analysis: Hybrid Systems.
Elsevier, 2020. https://doi.org/10.1016/j.nahs.2020.100856.'
ieee: 'M. Garcia Soto and P. Prabhakar, “Abstraction based verification of stability
of polyhedral switched systems,” Nonlinear Analysis: Hybrid Systems, vol.
36, no. 5. Elsevier, 2020.'
ista: 'Garcia Soto M, Prabhakar P. 2020. Abstraction based verification of stability
of polyhedral switched systems. Nonlinear Analysis: Hybrid Systems. 36(5), 100856.'
mla: 'Garcia Soto, Miriam, and Pavithra Prabhakar. “Abstraction Based Verification
of Stability of Polyhedral Switched Systems.” Nonlinear Analysis: Hybrid Systems,
vol. 36, no. 5, 100856, Elsevier, 2020, doi:10.1016/j.nahs.2020.100856.'
short: 'M. Garcia Soto, P. Prabhakar, Nonlinear Analysis: Hybrid Systems 36 (2020).'
date_created: 2020-02-02T23:00:59Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2023-08-17T14:32:54Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1016/j.nahs.2020.100856
external_id:
isi:
- '000528828600003'
file:
- access_level: open_access
checksum: 560abfddb53f9fe921b6744f59f2cfaa
content_type: application/pdf
creator: dernst
date_created: 2020-10-21T13:16:45Z
date_updated: 2022-05-16T22:30:04Z
embargo: 2022-05-15
file_id: '8688'
file_name: 2020_NAHS_GarciaSoto.pdf
file_size: 818774
relation: main_file
file_date_updated: 2022-05-16T22:30:04Z
has_accepted_license: '1'
intvolume: ' 36'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: 'Nonlinear Analysis: Hybrid Systems'
publication_identifier:
issn:
- 1751-570X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Abstraction based verification of stability of polyhedral switched systems
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 36
year: '2020'
...
---
_id: '8983'
abstract:
- lang: eng
text: Metabolic adaptation is a critical feature of migrating cells. It tunes the
metabolic programs of migrating cells to allow them to efficiently exert their
crucial roles in development, inflammatory responses and tumor metastasis. Cell
migration through physically challenging contexts requires energy. However, how
the metabolic reprogramming that underlies in vivo cell invasion is controlled
is still unanswered. In my PhD project, I identify a novel conserved metabolic
shift in Drosophila melanogaster immune cells that by modulating their bioenergetic
potential controls developmentally programmed tissue invasion. We show that this
regulation requires a novel conserved nuclear protein, named Atossa. Atossa enhances
the transcription of a set of proteins, including an RNA helicase Porthos and
two metabolic enzymes, each of which increases the tissue invasion of leading
Drosophila macrophages and can rescue the atossa mutant phenotype. Porthos selectively
regulates the translational efficiency of a subset of mRNAs containing a 5’-UTR
cis-regulatory TOP-like sequence. These 5’TOPL mRNA targets encode mitochondrial-related
proteins, including subunits of mitochondrial oxidative phosphorylation (OXPHOS)
components III and V and other metabolic-related proteins. Porthos powers up mitochondrial
OXPHOS to engender a sufficient ATP supply, which is required for tissue invasion
of leading macrophages. Atossa’s two vertebrate orthologs rescue the invasion
defect. In my PhD project, I elucidate that Atossa displays a conserved developmental
metabolic control to modulate metabolic capacities and the cellular energy state,
through altered transcription and translation, to aid the tissue infiltration
of leading cells into energy demanding barriers.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: E-Lib
- _id: CampIT
acknowledgement: Also, I would like to express my appreciation and thanks to the Bioimaging
facility, LSF, GSO, library, and IT people at IST Austria.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Shamsi
full_name: Emtenani, Shamsi
id: 49D32318-F248-11E8-B48F-1D18A9856A87
last_name: Emtenani
orcid: 0000-0001-6981-6938
citation:
ama: Emtenani S. Metabolic regulation of Drosophila macrophage tissue invasion.
2020. doi:10.15479/AT:ISTA:8983
apa: Emtenani, S. (2020). Metabolic regulation of Drosophila macrophage tissue
invasion. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8983
chicago: Emtenani, Shamsi. “Metabolic Regulation of Drosophila Macrophage Tissue
Invasion.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8983.
ieee: S. Emtenani, “Metabolic regulation of Drosophila macrophage tissue invasion,”
Institute of Science and Technology Austria, 2020.
ista: Emtenani S. 2020. Metabolic regulation of Drosophila macrophage tissue invasion.
Institute of Science and Technology Austria.
mla: Emtenani, Shamsi. Metabolic Regulation of Drosophila Macrophage Tissue Invasion.
Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8983.
short: S. Emtenani, Metabolic Regulation of Drosophila Macrophage Tissue Invasion,
Institute of Science and Technology Austria, 2020.
date_created: 2020-12-30T15:41:26Z
date_published: 2020-12-30T00:00:00Z
date_updated: 2023-09-07T13:24:17Z
day: '30'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: DaSi
doi: 10.15479/AT:ISTA:8983
file:
- access_level: open_access
checksum: ec2797ab7a6f253b35df0572b36d1b43
content_type: application/pdf
creator: semtenan
date_created: 2020-12-30T15:34:01Z
date_updated: 2021-12-31T23:30:04Z
embargo: 2021-12-30
file_id: '8984'
file_name: Thesis_Shamsi_Emtenani_pdfA.pdf
file_size: 10848175
relation: main_file
- access_level: closed
checksum: cc30e6608a9815414024cf548dff3b3a
content_type: application/pdf
creator: semtenan
date_created: 2020-12-30T15:37:36Z
date_updated: 2021-12-31T23:30:04Z
embargo_to: open_access
file_id: '8985'
file_name: Thesis_Shamsi_Emtenani_source file.pdf
file_size: 10073648
relation: source_file
file_date_updated: 2021-12-31T23:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '141'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8557'
relation: part_of_dissertation
status: public
- id: '6187'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
title: Metabolic regulation of Drosophila macrophage tissue invasion
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '8557'
abstract:
- lang: eng
text: The infiltration of immune cells into tissues underlies the establishment
of tissue resident macrophages, and responses to infections and tumors. Yet the
mechanisms immune cells utilize to negotiate tissue barriers in living organisms
are not well understood, and a role for cortical actin has not been examined.
Here we find that the tissue invasion of Drosophila macrophages, also known as
plasmatocytes or hemocytes, utilizes enhanced cortical F-actin levels stimulated
by the Drosophila member of the fos proto oncogene transcription factor family
(Dfos, Kayak). RNA sequencing analysis and live imaging show that Dfos enhances
F-actin levels around the entire macrophage surface by increasing mRNA levels
of the membrane spanning molecular scaffold tetraspanin TM4SF, and the actin cross-linking
filamin Cheerio which are themselves required for invasion. Cortical F-actin levels
are critical as expressing a dominant active form of Diaphanous, a actin polymerizing
Formin, can rescue the Dfos Dominant Negative macrophage invasion defect. In vivo
imaging shows that Dfos is required to enhance the efficiency of the initial phases
of macrophage tissue entry. Genetic evidence argues that this Dfos-induced program
in macrophages counteracts the constraint produced by the tension of surrounding
tissues and buffers the mechanical properties of the macrophage nucleus from affecting
tissue entry. We thus identify tuning the cortical actin cytoskeleton through
Dfos as a key process allowing efficient forward movement of an immune cell into
surrounding tissues.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: 'We thank the following for their contributions: The Drosophila Genomics
Resource Center supported by NIH grant 2P40OD010949-10A1 for plasmids, K. Brueckner.
B. Stramer, M. Uhlirova, O. Schuldiner, the Bloomington Drosophila Stock Center
supported by NIH grant P40OD018537 and the Vienna Drosophila Resource Center for
fly stocks, FlyBase (Thurmond et al., 2019) for essential genomic information, and
the BDGP in situ database for data (Tomancak et al., 2002, 2007). For antibodies,
we thank the Developmental Studies Hybridoma Bank, which was created by the Eunice
Kennedy Shriver National Institute of Child Health and Human Development of the
NIH, and is maintained at the University of Iowa, as well as J. Zeitlinger for her
generous gift of Dfos antibody. We thank the Vienna BioCenter Core Facilities for
RNA sequencing and analysis and the Life Scientific Service Units at IST Austria
for technical support and assistance with microscopy and FACS analysis. We thank
C.P. Heisenberg, P. Martin, M. Sixt and Siekhaus group members for discussions and
T.Hurd, A. Ratheesh and P. Rangan for comments on the manuscript. A.G. was supported
by the Austrian Science Fund (FWF) grant DASI_FWF01_P29638S, D.E.S. by Marie Curie
CIG 334077/IRTIM. M.S. is supported by the FWF, PhD program W1212 915 and the European
Research Council (ERC) Advanced grant (ERC-2015-AdG TNT-Tumors 694883). S.W. is
supported by an OEAW, DOC fellowship.'
article_processing_charge: No
author:
- first_name: Vera
full_name: Belyaeva, Vera
id: 47F080FE-F248-11E8-B48F-1D18A9856A87
last_name: Belyaeva
- first_name: Stephanie
full_name: Wachner, Stephanie
id: 2A95E7B0-F248-11E8-B48F-1D18A9856A87
last_name: Wachner
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Markus
full_name: Linder, Markus
last_name: Linder
- first_name: Shamsi
full_name: Emtenani, Shamsi
id: 49D32318-F248-11E8-B48F-1D18A9856A87
last_name: Emtenani
orcid: 0000-0001-6981-6938
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Maria
full_name: Sibilia, Maria
last_name: Sibilia
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
citation:
ama: Belyaeva V, Wachner S, Gridchyn I, et al. Cortical actin properties controlled
by Drosophila Fos aid macrophage infiltration against surrounding tissue resistance.
bioRxiv. doi:10.1101/2020.09.18.301481
apa: Belyaeva, V., Wachner, S., Gridchyn, I., Linder, M., Emtenani, S., György,
A., … Siekhaus, D. E. (n.d.). Cortical actin properties controlled by Drosophila
Fos aid macrophage infiltration against surrounding tissue resistance. bioRxiv.
https://doi.org/10.1101/2020.09.18.301481
chicago: Belyaeva, Vera, Stephanie Wachner, Igor Gridchyn, Markus Linder, Shamsi
Emtenani, Attila György, Maria Sibilia, and Daria E Siekhaus. “Cortical Actin
Properties Controlled by Drosophila Fos Aid Macrophage Infiltration against Surrounding
Tissue Resistance.” BioRxiv, n.d. https://doi.org/10.1101/2020.09.18.301481.
ieee: V. Belyaeva et al., “Cortical actin properties controlled by Drosophila
Fos aid macrophage infiltration against surrounding tissue resistance,” bioRxiv.
.
ista: Belyaeva V, Wachner S, Gridchyn I, Linder M, Emtenani S, György A, Sibilia
M, Siekhaus DE. Cortical actin properties controlled by Drosophila Fos aid macrophage
infiltration against surrounding tissue resistance. bioRxiv, 10.1101/2020.09.18.301481.
mla: Belyaeva, Vera, et al. “Cortical Actin Properties Controlled by Drosophila
Fos Aid Macrophage Infiltration against Surrounding Tissue Resistance.” BioRxiv,
doi:10.1101/2020.09.18.301481.
short: V. Belyaeva, S. Wachner, I. Gridchyn, M. Linder, S. Emtenani, A. György,
M. Sibilia, D.E. Siekhaus, BioRxiv (n.d.).
date_created: 2020-09-23T09:36:47Z
date_published: 2020-09-18T00:00:00Z
date_updated: 2024-03-27T23:30:24Z
day: '18'
department:
- _id: DaSi
- _id: JoCs
doi: 10.1101/2020.09.18.301481
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.09.18.301481
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: 253B6E48-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29638
name: Drosophila TNFa´s Funktion in Immunzellen
- _id: 2536F660-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '334077'
name: Investigating the role of transporters in invasive migration through junctions
- _id: 26199CA4-B435-11E9-9278-68D0E5697425
grant_number: '24800'
name: Tissue barrier penetration is crucial for immunity and metastasis
publication: bioRxiv
publication_status: submitted
related_material:
record:
- id: '10614'
relation: later_version
status: public
- id: '8983'
relation: dissertation_contains
status: public
status: public
title: Cortical actin properties controlled by Drosophila Fos aid macrophage infiltration
against surrounding tissue resistance
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8831'
abstract:
- lang: eng
text: Holes in planar Ge have high mobilities, strong spin-orbit interaction and
electrically tunable g-factors, and are therefore emerging as a promising candidate
for hybrid superconductorsemiconductor devices. This is further motivated by the
observation of supercurrent transport in planar Ge Josephson Field effect transistors
(JoFETs). A key challenge towards hybrid germanium quantum technology is the design
of high quality interfaces and superconducting contacts that are robust against
magnetic fields. By combining the assets of Al, which has a long superconducting
coherence, and Nb, which has a significant superconducting gap, we form low-disordered
JoFETs with large ICRN products that are capable of withstanding high magnetic
fields. We furthermore demonstrate the ability of phase-biasing individual JoFETs
opening up an avenue to explore topological superconductivity in planar Ge. The
persistence of superconductivity in the reported hybrid devices beyond 1.8 T paves
the way towards integrating spin qubits and proximity-induced superconductivity
on the same chip.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: "This research and related results were made possible with the support
of the NOMIS Foundation. This research was supported by the Scientific Service Units
of IST Austria through resources provided by the MIBA Machine Shop and the nanofabrication
facility, the European Union’s Horizon 2020 research and innovation program under
the Marie Sklodowska-Curie grant agreement #844511 and the Grant Agreement #862046.
ICN2 acknowledge funding from Generalitat de Catalunya 2017 SGR 327. ICN2 is supported
by the Severo Ochoa\r\nprogram from Spanish MINECO (Grant No. SEV2017-0706) and
is funded by the CERCA Programme / Generalitat de Catalunya. Part of the present
work has been performed in the framework of Universitat Aut`onoma de Barcelona Materials
Science PhD program. The HAADF-STEM microscopy was conducted in the Laboratorio
de Microscopias Avanzadas at Instituto de Nanociencia de Aragon-Universidad de Zaragoza.
Authors acknowledge the LMA-INA for offering access to their instruments and expertise.
We acknowledge support from CSIC Research Platform on Quantum Technologies PTI-001.
This project has received funding from\r\nthe European Union’s Horizon 2020 research
and innovation programme under grant agreement No 823717 – ESTEEM3. M.B. acknowledges
support from SUR Generalitat de Catalunya and the EU Social Fund; project ref. 2020
FI 00103. GS and MV acknowledge support through a projectruimte grant associated
with the Netherlands Organization of Scientific Research (NWO)."
article_number: '2012.00322'
article_processing_charge: No
author:
- first_name: Kushagra
full_name: Aggarwal, Kushagra
id: b22ab905-3539-11eb-84c3-fc159dcd79cb
last_name: Aggarwal
orcid: 0000-0001-9985-9293
- first_name: Andrea C
full_name: Hofmann, Andrea C
id: 340F461A-F248-11E8-B48F-1D18A9856A87
last_name: Hofmann
- first_name: Daniel
full_name: Jirovec, Daniel
id: 4C473F58-F248-11E8-B48F-1D18A9856A87
last_name: Jirovec
orcid: 0000-0002-7197-4801
- first_name: Ivan
full_name: Prieto Gonzalez, Ivan
id: 2A307FE2-F248-11E8-B48F-1D18A9856A87
last_name: Prieto Gonzalez
orcid: 0000-0002-7370-5357
- first_name: Amir
full_name: Sammak, Amir
last_name: Sammak
- first_name: Marc
full_name: Botifoll, Marc
last_name: Botifoll
- first_name: Sara
full_name: Marti-Sanchez, Sara
last_name: Marti-Sanchez
- first_name: Menno
full_name: Veldhorst, Menno
last_name: Veldhorst
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Giordano
full_name: Scappucci, Giordano
last_name: Scappucci
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Aggarwal K, Hofmann AC, Jirovec D, et al. Enhancement of proximity induced
superconductivity in planar Germanium. arXiv.
apa: Aggarwal, K., Hofmann, A. C., Jirovec, D., Prieto Gonzalez, I., Sammak, A.,
Botifoll, M., … Katsaros, G. (n.d.). Enhancement of proximity induced superconductivity
in planar Germanium. arXiv.
chicago: Aggarwal, Kushagra, Andrea C Hofmann, Daniel Jirovec, Ivan Prieto Gonzalez,
Amir Sammak, Marc Botifoll, Sara Marti-Sanchez, et al. “Enhancement of Proximity
Induced Superconductivity in Planar Germanium.” ArXiv, n.d.
ieee: K. Aggarwal et al., “Enhancement of proximity induced superconductivity
in planar Germanium,” arXiv. .
ista: Aggarwal K, Hofmann AC, Jirovec D, Prieto Gonzalez I, Sammak A, Botifoll M,
Marti-Sanchez S, Veldhorst M, Arbiol J, Scappucci G, Katsaros G. Enhancement of
proximity induced superconductivity in planar Germanium. arXiv, 2012.00322.
mla: Aggarwal, Kushagra, et al. “Enhancement of Proximity Induced Superconductivity
in Planar Germanium.” ArXiv, 2012.00322.
short: K. Aggarwal, A.C. Hofmann, D. Jirovec, I. Prieto Gonzalez, A. Sammak, M.
Botifoll, S. Marti-Sanchez, M. Veldhorst, J. Arbiol, G. Scappucci, G. Katsaros,
ArXiv (n.d.).
date_created: 2020-12-02T10:42:53Z
date_published: 2020-12-02T00:00:00Z
date_updated: 2024-03-27T23:30:26Z
day: '02'
ddc:
- '530'
department:
- _id: GeKa
ec_funded: 1
external_id:
arxiv:
- '2012.00322'
file:
- access_level: open_access
checksum: 22a612e206232fa94b138b2c2f957582
content_type: application/pdf
creator: gkatsaro
date_created: 2020-12-02T10:42:31Z
date_updated: 2020-12-02T10:42:31Z
file_id: '8832'
file_name: Superconducting_2D_Ge.pdf
file_size: 1697939
relation: main_file
file_date_updated: 2020-12-02T10:42:31Z
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Submitted Version
project:
- _id: 262116AA-B435-11E9-9278-68D0E5697425
name: Hybrid Semiconductor - Superconductor Quantum Devices
- _id: 26A151DA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '844511'
name: Majorana bound states in Ge/SiGe heterostructures
- _id: 237E5020-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862046'
name: TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS
publication: arXiv
publication_status: submitted
related_material:
record:
- id: '10559'
relation: later_version
status: public
- id: '8834'
relation: research_data
status: public
- id: '10058'
relation: dissertation_contains
status: public
status: public
title: Enhancement of proximity induced superconductivity in planar Germanium
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8532'
abstract:
- lang: eng
text: The molecular anatomy of synapses defines their characteristics in transmission
and plasticity. Precise measurements of the number and distribution of synaptic
proteins are important for our understanding of synapse heterogeneity within and
between brain regions. Freeze–fracture replica immunogold electron microscopy
enables us to analyze them quantitatively on a two-dimensional membrane surface.
Here, we introduce Darea software, which utilizes deep learning for analysis of
replica images and demonstrate its usefulness for quick measurements of the pre-
and postsynaptic areas, density and distribution of gold particles at synapses
in a reproducible manner. We used Darea for comparing glutamate receptor and calcium
channel distributions between hippocampal CA3-CA1 spine synapses on apical and
basal dendrites, which differ in signaling pathways involved in synaptic plasticity.
We found that apical synapses express a higher density of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA) receptors and a stronger increase of AMPA receptors with synaptic
size, while basal synapses show a larger increase in N-methyl-D-aspartate (NMDA)
receptors with size. Interestingly, AMPA and NMDA receptors are segregated within
postsynaptic sites and negatively correlated in density among both apical and
basal synapses. In the presynaptic sites, Cav2.1 voltage-gated calcium channels
show similar densities in apical and basal synapses with distributions consistent
with an exclusion zone model of calcium channel-release site topography.
acknowledgement: "This research was funded by Austrian Academy of Sciences, DOC fellowship
to D.K., European Research\r\nCouncil Advanced Grant 694539 and European Union Human
Brain Project (HBP) SGA2 785907 to R.S.\r\nWe acknowledge Elena Hollergschwandtner
for technical support."
article_number: '6737'
article_processing_charge: No
article_type: original
author:
- first_name: David
full_name: Kleindienst, David
id: 42E121A4-F248-11E8-B48F-1D18A9856A87
last_name: Kleindienst
- first_name: Jacqueline-Claire
full_name: Montanaro-Punzengruber, Jacqueline-Claire
id: 3786AB44-F248-11E8-B48F-1D18A9856A87
last_name: Montanaro-Punzengruber
- first_name: Pradeep
full_name: Bhandari, Pradeep
id: 45EDD1BC-F248-11E8-B48F-1D18A9856A87
last_name: Bhandari
orcid: 0000-0003-0863-4481
- first_name: Matthew J
full_name: Case, Matthew J
id: 44B7CA5A-F248-11E8-B48F-1D18A9856A87
last_name: Case
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Kleindienst D, Montanaro-Punzengruber J-C, Bhandari P, Case MJ, Fukazawa Y,
Shigemoto R. Deep learning-assisted high-throughput analysis of freeze-fracture
replica images applied to glutamate receptors and calcium channels at hippocampal
synapses. International Journal of Molecular Sciences. 2020;21(18). doi:10.3390/ijms21186737
apa: Kleindienst, D., Montanaro-Punzengruber, J.-C., Bhandari, P., Case, M. J.,
Fukazawa, Y., & Shigemoto, R. (2020). Deep learning-assisted high-throughput
analysis of freeze-fracture replica images applied to glutamate receptors and
calcium channels at hippocampal synapses. International Journal of Molecular
Sciences. MDPI. https://doi.org/10.3390/ijms21186737
chicago: Kleindienst, David, Jacqueline-Claire Montanaro-Punzengruber, Pradeep Bhandari,
Matthew J Case, Yugo Fukazawa, and Ryuichi Shigemoto. “Deep Learning-Assisted
High-Throughput Analysis of Freeze-Fracture Replica Images Applied to Glutamate
Receptors and Calcium Channels at Hippocampal Synapses.” International Journal
of Molecular Sciences. MDPI, 2020. https://doi.org/10.3390/ijms21186737.
ieee: D. Kleindienst, J.-C. Montanaro-Punzengruber, P. Bhandari, M. J. Case, Y.
Fukazawa, and R. Shigemoto, “Deep learning-assisted high-throughput analysis of
freeze-fracture replica images applied to glutamate receptors and calcium channels
at hippocampal synapses,” International Journal of Molecular Sciences,
vol. 21, no. 18. MDPI, 2020.
ista: Kleindienst D, Montanaro-Punzengruber J-C, Bhandari P, Case MJ, Fukazawa Y,
Shigemoto R. 2020. Deep learning-assisted high-throughput analysis of freeze-fracture
replica images applied to glutamate receptors and calcium channels at hippocampal
synapses. International Journal of Molecular Sciences. 21(18), 6737.
mla: Kleindienst, David, et al. “Deep Learning-Assisted High-Throughput Analysis
of Freeze-Fracture Replica Images Applied to Glutamate Receptors and Calcium Channels
at Hippocampal Synapses.” International Journal of Molecular Sciences,
vol. 21, no. 18, 6737, MDPI, 2020, doi:10.3390/ijms21186737.
short: D. Kleindienst, J.-C. Montanaro-Punzengruber, P. Bhandari, M.J. Case, Y.
Fukazawa, R. Shigemoto, International Journal of Molecular Sciences 21 (2020).
date_created: 2020-09-20T22:01:35Z
date_published: 2020-09-14T00:00:00Z
date_updated: 2024-03-27T23:30:30Z
day: '14'
ddc:
- '570'
department:
- _id: RySh
doi: 10.3390/ijms21186737
ec_funded: 1
external_id:
isi:
- '000579945300001'
file:
- access_level: open_access
checksum: 2e4f62f3cfe945b7391fc3070e5a289f
content_type: application/pdf
creator: dernst
date_created: 2020-09-21T14:08:58Z
date_updated: 2020-09-21T14:08:58Z
file_id: '8551'
file_name: 2020_JournMolecSciences_Kleindienst.pdf
file_size: 5748456
relation: main_file
success: 1
file_date_updated: 2020-09-21T14:08:58Z
has_accepted_license: '1'
intvolume: ' 21'
isi: 1
issue: '18'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: 25CA28EA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694539'
name: 'In situ analysis of single channel subunit composition in neurons: physiological
implication in synaptic plasticity and behaviour'
- _id: 25D32BC0-B435-11E9-9278-68D0E5697425
name: Mechanism of formation and maintenance of input side-dependent asymmetry in
the hippocampus
- _id: 26436750-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '785907'
name: Human Brain Project Specific Grant Agreement 2 (HBP SGA 2)
publication: International Journal of Molecular Sciences
publication_identifier:
eissn:
- '14220067'
issn:
- '16616596'
publication_status: published
publisher: MDPI
quality_controlled: '1'
related_material:
record:
- id: '9562'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Deep learning-assisted high-throughput analysis of freeze-fracture replica
images applied to glutamate receptors and calcium channels at hippocampal synapses
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 21
year: '2020'
...
---
_id: '7810'
abstract:
- lang: eng
text: "Interprocedural data-flow analyses form an expressive and useful paradigm
of numerous static analysis applications, such as live variables analysis, alias
analysis and null pointers analysis. The most widely-used framework for interprocedural
data-flow analysis is IFDS, which encompasses distributive data-flow functions
over a finite domain. On-demand data-flow analyses restrict the focus of the analysis
on specific program locations and data facts. This setting provides a natural
split between (i) an offline (or preprocessing) phase, where the program is partially
analyzed and analysis summaries are created, and (ii) an online (or query) phase,
where analysis queries arrive on demand and the summaries are used to speed up
answering queries.\r\nIn this work, we consider on-demand IFDS analyses where
the queries concern program locations of the same procedure (aka same-context
queries). We exploit the fact that flow graphs of programs have low treewidth
to develop faster algorithms that are space and time optimal for many common data-flow
analyses, in both the preprocessing and the query phase. We also use treewidth
to develop query solutions that are embarrassingly parallelizable, i.e. the total
work for answering each query is split to a number of threads such that each thread
performs only a constant amount of work. Finally, we implement a static analyzer
based on our algorithms, and perform a series of on-demand analysis experiments
on standard benchmarks. Our experimental results show a drastic speed-up of the
queries after only a lightweight preprocessing phase, which significantly outperforms
existing techniques."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Amir Kafshdar
full_name: Goharshady, Amir Kafshdar
id: 391365CE-F248-11E8-B48F-1D18A9856A87
last_name: Goharshady
orcid: 0000-0003-1702-6584
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
citation:
ama: 'Chatterjee K, Goharshady AK, Ibsen-Jensen R, Pavlogiannis A. Optimal and perfectly
parallel algorithms for on-demand data-flow analysis. In: European Symposium
on Programming. Vol 12075. Springer Nature; 2020:112-140. doi:10.1007/978-3-030-44914-8_5'
apa: 'Chatterjee, K., Goharshady, A. K., Ibsen-Jensen, R., & Pavlogiannis, A.
(2020). Optimal and perfectly parallel algorithms for on-demand data-flow analysis.
In European Symposium on Programming (Vol. 12075, pp. 112–140). Dublin,
Ireland: Springer Nature. https://doi.org/10.1007/978-3-030-44914-8_5'
chicago: Chatterjee, Krishnendu, Amir Kafshdar Goharshady, Rasmus Ibsen-Jensen,
and Andreas Pavlogiannis. “Optimal and Perfectly Parallel Algorithms for On-Demand
Data-Flow Analysis.” In European Symposium on Programming, 12075:112–40.
Springer Nature, 2020. https://doi.org/10.1007/978-3-030-44914-8_5.
ieee: K. Chatterjee, A. K. Goharshady, R. Ibsen-Jensen, and A. Pavlogiannis, “Optimal
and perfectly parallel algorithms for on-demand data-flow analysis,” in European
Symposium on Programming, Dublin, Ireland, 2020, vol. 12075, pp. 112–140.
ista: 'Chatterjee K, Goharshady AK, Ibsen-Jensen R, Pavlogiannis A. 2020. Optimal
and perfectly parallel algorithms for on-demand data-flow analysis. European Symposium
on Programming. ESOP: Programming Languages and Systems, LNCS, vol. 12075, 112–140.'
mla: Chatterjee, Krishnendu, et al. “Optimal and Perfectly Parallel Algorithms for
On-Demand Data-Flow Analysis.” European Symposium on Programming, vol.
12075, Springer Nature, 2020, pp. 112–40, doi:10.1007/978-3-030-44914-8_5.
short: K. Chatterjee, A.K. Goharshady, R. Ibsen-Jensen, A. Pavlogiannis, in:, European
Symposium on Programming, Springer Nature, 2020, pp. 112–140.
conference:
end_date: 2020-04-30
location: Dublin, Ireland
name: 'ESOP: Programming Languages and Systems'
start_date: 2020-04-25
date_created: 2020-05-10T22:00:50Z
date_published: 2020-04-18T00:00:00Z
date_updated: 2024-03-27T23:30:33Z
day: '18'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1007/978-3-030-44914-8_5
external_id:
isi:
- '000681656800005'
file:
- access_level: open_access
checksum: 8618b80f4cf7b39a60e61a6445ad9807
content_type: application/pdf
creator: dernst
date_created: 2020-05-26T13:34:48Z
date_updated: 2020-07-14T12:48:03Z
file_id: '7895'
file_name: 2020_LNCS_Chatterjee.pdf
file_size: 651250
relation: main_file
file_date_updated: 2020-07-14T12:48:03Z
has_accepted_license: '1'
intvolume: ' 12075'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 112-140
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
grant_number: ICT15-003
name: Efficient Algorithms for Computer Aided Verification
- _id: 266EEEC0-B435-11E9-9278-68D0E5697425
name: Quantitative Game-theoretic Analysis of Blockchain Applications and Smart
Contracts
- _id: 267066CE-B435-11E9-9278-68D0E5697425
name: Quantitative Analysis of Probablistic Systems with a focus on Crypto-currencies
publication: European Symposium on Programming
publication_identifier:
eissn:
- '16113349'
isbn:
- '9783030449131'
issn:
- '03029743'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '8934'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Optimal and perfectly parallel algorithms for on-demand data-flow analysis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12075
year: '2020'
...
---
_id: '8728'
abstract:
- lang: eng
text: Discrete-time Markov Chains (MCs) and Markov Decision Processes (MDPs) are
two standard formalisms in system analysis. Their main associated quantitative
objectives are hitting probabilities, discounted sum, and mean payoff. Although
there are many techniques for computing these objectives in general MCs/MDPs,
they have not been thoroughly studied in terms of parameterized algorithms, particularly
when treewidth is used as the parameter. This is in sharp contrast to qualitative
objectives for MCs, MDPs and graph games, for which treewidth-based algorithms
yield significant complexity improvements. In this work, we show that treewidth
can also be used to obtain faster algorithms for the quantitative problems. For
an MC with n states and m transitions, we show that each of the classical quantitative
objectives can be computed in O((n+m)⋅t2) time, given a tree decomposition
of the MC with width t. Our results also imply a bound of O(κ⋅(n+m)⋅t2) for
each objective on MDPs, where κ is the number of strategy-iteration refinements
required for the given input and objective. Finally, we make an experimental evaluation
of our new algorithms on low-treewidth MCs and MDPs obtained from the DaCapo benchmark
suite. Our experiments show that on low-treewidth MCs and MDPs, our algorithms
outperform existing well-established methods by one or more orders of magnitude.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Ali
full_name: Asadi, Ali
last_name: Asadi
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Amir Kafshdar
full_name: Goharshady, Amir Kafshdar
id: 391365CE-F248-11E8-B48F-1D18A9856A87
last_name: Goharshady
orcid: 0000-0003-1702-6584
- first_name: Kiarash
full_name: Mohammadi, Kiarash
last_name: Mohammadi
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
citation:
ama: 'Asadi A, Chatterjee K, Goharshady AK, Mohammadi K, Pavlogiannis A. Faster
algorithms for quantitative analysis of MCs and MDPs with small treewidth. In:
Automated Technology for Verification and Analysis. Vol 12302. Springer
Nature; 2020:253-270. doi:10.1007/978-3-030-59152-6_14'
apa: 'Asadi, A., Chatterjee, K., Goharshady, A. K., Mohammadi, K., & Pavlogiannis,
A. (2020). Faster algorithms for quantitative analysis of MCs and MDPs with small
treewidth. In Automated Technology for Verification and Analysis (Vol.
12302, pp. 253–270). Hanoi, Vietnam: Springer Nature. https://doi.org/10.1007/978-3-030-59152-6_14'
chicago: Asadi, Ali, Krishnendu Chatterjee, Amir Kafshdar Goharshady, Kiarash Mohammadi,
and Andreas Pavlogiannis. “Faster Algorithms for Quantitative Analysis of MCs
and MDPs with Small Treewidth.” In Automated Technology for Verification and
Analysis, 12302:253–70. Springer Nature, 2020. https://doi.org/10.1007/978-3-030-59152-6_14.
ieee: A. Asadi, K. Chatterjee, A. K. Goharshady, K. Mohammadi, and A. Pavlogiannis,
“Faster algorithms for quantitative analysis of MCs and MDPs with small treewidth,”
in Automated Technology for Verification and Analysis, Hanoi, Vietnam,
2020, vol. 12302, pp. 253–270.
ista: 'Asadi A, Chatterjee K, Goharshady AK, Mohammadi K, Pavlogiannis A. 2020.
Faster algorithms for quantitative analysis of MCs and MDPs with small treewidth.
Automated Technology for Verification and Analysis. ATVA: Automated Technology
for Verification and Analysis, LNCS, vol. 12302, 253–270.'
mla: Asadi, Ali, et al. “Faster Algorithms for Quantitative Analysis of MCs and
MDPs with Small Treewidth.” Automated Technology for Verification and Analysis,
vol. 12302, Springer Nature, 2020, pp. 253–70, doi:10.1007/978-3-030-59152-6_14.
short: A. Asadi, K. Chatterjee, A.K. Goharshady, K. Mohammadi, A. Pavlogiannis,
in:, Automated Technology for Verification and Analysis, Springer Nature, 2020,
pp. 253–270.
conference:
end_date: 2020-10-23
location: Hanoi, Vietnam
name: 'ATVA: Automated Technology for Verification and Analysis'
start_date: 2020-10-19
date_created: 2020-11-06T07:30:05Z
date_published: 2020-10-12T00:00:00Z
date_updated: 2024-03-27T23:30:33Z
day: '12'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1007/978-3-030-59152-6_14
external_id:
isi:
- '000723555700014'
file:
- access_level: open_access
checksum: ae83f27e5b189d5abc2e7514f1b7e1b5
content_type: application/pdf
creator: dernst
date_created: 2020-11-06T07:41:03Z
date_updated: 2020-11-06T07:41:03Z
file_id: '8729'
file_name: 2020_LNCS_ATVA_Asadi_accepted.pdf
file_size: 726648
relation: main_file
success: 1
file_date_updated: 2020-11-06T07:41:03Z
has_accepted_license: '1'
intvolume: ' 12302'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 253-270
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
grant_number: ICT15-003
name: Efficient Algorithms for Computer Aided Verification
- _id: 267066CE-B435-11E9-9278-68D0E5697425
name: Quantitative Analysis of Probablistic Systems with a focus on Crypto-currencies
publication: Automated Technology for Verification and Analysis
publication_identifier:
eisbn:
- '9783030591526'
eissn:
- 1611-3349
isbn:
- '9783030591519'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '8934'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Faster algorithms for quantitative analysis of MCs and MDPs with small treewidth
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 12302
year: '2020'
...
---
_id: '8089'
abstract:
- lang: eng
text: "We consider the classical problem of invariant generation for programs with
polynomial assignments and focus on synthesizing invariants that are a conjunction
of strict polynomial inequalities. We present a sound and semi-complete method
based on positivstellensaetze, i.e. theorems in semi-algebraic geometry that characterize
positive polynomials over a semi-algebraic set.\r\n\r\nOn the theoretical side,
the worst-case complexity of our approach is subexponential, whereas the worst-case
complexity of the previous complete method (Kapur, ACA 2004) is doubly-exponential.
Even when restricted to linear invariants, the best previous complexity for complete
invariant generation is exponential (Colon et al, CAV 2003). On the practical
side, we reduce the invariant generation problem to quadratic programming (QCLP),
which is a classical optimization problem with many industrial solvers. We demonstrate
the applicability of our approach by providing experimental results on several
academic benchmarks. To the best of our knowledge, the only previous invariant
generation method that provides completeness guarantees for invariants consisting
of polynomial inequalities is (Kapur, ACA 2004), which relies on quantifier elimination
and cannot even handle toy programs such as our running example."
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Hongfei
full_name: Fu, Hongfei
id: 3AAD03D6-F248-11E8-B48F-1D18A9856A87
last_name: Fu
- first_name: Amir Kafshdar
full_name: Goharshady, Amir Kafshdar
id: 391365CE-F248-11E8-B48F-1D18A9856A87
last_name: Goharshady
orcid: 0000-0003-1702-6584
- first_name: Ehsan Kafshdar
full_name: Goharshady, Ehsan Kafshdar
last_name: Goharshady
citation:
ama: 'Chatterjee K, Fu H, Goharshady AK, Goharshady EK. Polynomial invariant generation
for non-deterministic recursive programs. In: Proceedings of the 41st ACM SIGPLAN
Conference on Programming Language Design and Implementation. Association
for Computing Machinery; 2020:672-687. doi:10.1145/3385412.3385969'
apa: 'Chatterjee, K., Fu, H., Goharshady, A. K., & Goharshady, E. K. (2020).
Polynomial invariant generation for non-deterministic recursive programs. In Proceedings
of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation
(pp. 672–687). London, United Kingdom: Association for Computing Machinery. https://doi.org/10.1145/3385412.3385969'
chicago: Chatterjee, Krishnendu, Hongfei Fu, Amir Kafshdar Goharshady, and Ehsan
Kafshdar Goharshady. “Polynomial Invariant Generation for Non-Deterministic Recursive
Programs.” In Proceedings of the 41st ACM SIGPLAN Conference on Programming
Language Design and Implementation, 672–87. Association for Computing Machinery,
2020. https://doi.org/10.1145/3385412.3385969.
ieee: K. Chatterjee, H. Fu, A. K. Goharshady, and E. K. Goharshady, “Polynomial
invariant generation for non-deterministic recursive programs,” in Proceedings
of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation,
London, United Kingdom, 2020, pp. 672–687.
ista: 'Chatterjee K, Fu H, Goharshady AK, Goharshady EK. 2020. Polynomial invariant
generation for non-deterministic recursive programs. Proceedings of the 41st ACM
SIGPLAN Conference on Programming Language Design and Implementation. PLDI: Programming
Language Design and Implementation, 672–687.'
mla: Chatterjee, Krishnendu, et al. “Polynomial Invariant Generation for Non-Deterministic
Recursive Programs.” Proceedings of the 41st ACM SIGPLAN Conference on Programming
Language Design and Implementation, Association for Computing Machinery, 2020,
pp. 672–87, doi:10.1145/3385412.3385969.
short: K. Chatterjee, H. Fu, A.K. Goharshady, E.K. Goharshady, in:, Proceedings
of the 41st ACM SIGPLAN Conference on Programming Language Design and Implementation,
Association for Computing Machinery, 2020, pp. 672–687.
conference:
end_date: 2020-06-20
location: London, United Kingdom
name: 'PLDI: Programming Language Design and Implementation'
start_date: 2020-06-15
date_created: 2020-07-05T22:00:45Z
date_published: 2020-06-11T00:00:00Z
date_updated: 2024-03-27T23:30:33Z
day: '11'
department:
- _id: KrCh
doi: 10.1145/3385412.3385969
external_id:
arxiv:
- '1902.04373'
isi:
- '000614622300045'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1902.04373
month: '06'
oa: 1
oa_version: Preprint
page: 672-687
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
grant_number: ICT15-003
name: Efficient Algorithms for Computer Aided Verification
publication: Proceedings of the 41st ACM SIGPLAN Conference on Programming Language
Design and Implementation
publication_identifier:
isbn:
- '9781450376136'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
record:
- id: '8934'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Polynomial invariant generation for non-deterministic recursive programs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '6918'
abstract:
- lang: eng
text: "We consider the classic problem of Network Reliability. A network is given
together with a source vertex, one or more target vertices, and probabilities
assigned to each of the edges. Each edge of the network is operable with its associated
probability and the problem is to determine the probability of having at least
one source-to-target path that is entirely composed of operable edges. This problem
is known to be NP-hard.\r\n\r\nWe provide a novel scalable algorithm to solve
the Network Reliability problem when the treewidth of the underlying network is
small. We also show our algorithm’s applicability for real-world transit networks
that have small treewidth, including the metro networks of major cities, such
as London and Tokyo. Our algorithm leverages tree decompositions to shrink the
original graph into much smaller graphs, for which reliability can be efficiently
and exactly computed using a brute force method. To the best of our knowledge,
this is the first exact algorithm for Network Reliability that can scale to handle
real-world instances of the problem."
acknowledgement: We are grateful to the anonymous reviewers for their comments, which
significantly improved the present work. The research was partially supported by
the EPSRC Early Career Fellowship EP/R023379/1, grant no. SC7-1718-01 of the London
Mathematical Society, an IBM PhD Fellowship, and a DOC Fellowship of the Austrian
Academy of Sciences (ÖAW).
article_number: '106665'
article_processing_charge: No
article_type: original
author:
- first_name: Amir Kafshdar
full_name: Goharshady, Amir Kafshdar
id: 391365CE-F248-11E8-B48F-1D18A9856A87
last_name: Goharshady
orcid: 0000-0003-1702-6584
- first_name: Fatemeh
full_name: Mohammadi, Fatemeh
last_name: Mohammadi
citation:
ama: Goharshady AK, Mohammadi F. An efficient algorithm for computing network reliability
in small treewidth. Reliability Engineering and System Safety. 2020;193.
doi:10.1016/j.ress.2019.106665
apa: Goharshady, A. K., & Mohammadi, F. (2020). An efficient algorithm for computing
network reliability in small treewidth. Reliability Engineering and System
Safety. Elsevier. https://doi.org/10.1016/j.ress.2019.106665
chicago: Goharshady, Amir Kafshdar, and Fatemeh Mohammadi. “An Efficient Algorithm
for Computing Network Reliability in Small Treewidth.” Reliability Engineering
and System Safety. Elsevier, 2020. https://doi.org/10.1016/j.ress.2019.106665.
ieee: A. K. Goharshady and F. Mohammadi, “An efficient algorithm for computing network
reliability in small treewidth,” Reliability Engineering and System Safety,
vol. 193. Elsevier, 2020.
ista: Goharshady AK, Mohammadi F. 2020. An efficient algorithm for computing network
reliability in small treewidth. Reliability Engineering and System Safety. 193,
106665.
mla: Goharshady, Amir Kafshdar, and Fatemeh Mohammadi. “An Efficient Algorithm for
Computing Network Reliability in Small Treewidth.” Reliability Engineering
and System Safety, vol. 193, 106665, Elsevier, 2020, doi:10.1016/j.ress.2019.106665.
short: A.K. Goharshady, F. Mohammadi, Reliability Engineering and System Safety
193 (2020).
date_created: 2019-09-29T22:00:44Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2024-03-27T23:30:33Z
day: '01'
department:
- _id: KrCh
doi: 10.1016/j.ress.2019.106665
external_id:
arxiv:
- '1712.09692'
isi:
- '000501641400050'
intvolume: ' 193'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1712.09692
month: '01'
oa: 1
oa_version: Preprint
project:
- _id: 266EEEC0-B435-11E9-9278-68D0E5697425
name: Quantitative Game-theoretic Analysis of Blockchain Applications and Smart
Contracts
publication: Reliability Engineering and System Safety
publication_identifier:
issn:
- '09518320'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '8934'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: An efficient algorithm for computing network reliability in small treewidth
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 193
year: '2020'
...
---
_id: '7161'
abstract:
- lang: eng
text: In this paper, we introduce an inertial projection-type method with different
updating strategies for solving quasi-variational inequalities with strongly monotone
and Lipschitz continuous operators in real Hilbert spaces. Under standard assumptions,
we establish different strong convergence results for the proposed algorithm.
Primary numerical experiments demonstrate the potential applicability of our scheme
compared with some related methods in the literature.
acknowledgement: We are grateful to the anonymous referees and editor whose insightful
comments helped to considerably improve an earlier version of this paper. The research
of the first author is supported by an ERC Grant from the Institute of Science and
Technology (IST).
article_processing_charge: No
article_type: original
author:
- first_name: Yekini
full_name: Shehu, Yekini
id: 3FC7CB58-F248-11E8-B48F-1D18A9856A87
last_name: Shehu
orcid: 0000-0001-9224-7139
- first_name: Aviv
full_name: Gibali, Aviv
last_name: Gibali
- first_name: Simone
full_name: Sagratella, Simone
last_name: Sagratella
citation:
ama: Shehu Y, Gibali A, Sagratella S. Inertial projection-type methods for solving
quasi-variational inequalities in real Hilbert spaces. Journal of Optimization
Theory and Applications. 2020;184:877–894. doi:10.1007/s10957-019-01616-6
apa: Shehu, Y., Gibali, A., & Sagratella, S. (2020). Inertial projection-type
methods for solving quasi-variational inequalities in real Hilbert spaces. Journal
of Optimization Theory and Applications. Springer Nature. https://doi.org/10.1007/s10957-019-01616-6
chicago: Shehu, Yekini, Aviv Gibali, and Simone Sagratella. “Inertial Projection-Type
Methods for Solving Quasi-Variational Inequalities in Real Hilbert Spaces.” Journal
of Optimization Theory and Applications. Springer Nature, 2020. https://doi.org/10.1007/s10957-019-01616-6.
ieee: Y. Shehu, A. Gibali, and S. Sagratella, “Inertial projection-type methods
for solving quasi-variational inequalities in real Hilbert spaces,” Journal
of Optimization Theory and Applications, vol. 184. Springer Nature, pp. 877–894,
2020.
ista: Shehu Y, Gibali A, Sagratella S. 2020. Inertial projection-type methods for
solving quasi-variational inequalities in real Hilbert spaces. Journal of Optimization
Theory and Applications. 184, 877–894.
mla: Shehu, Yekini, et al. “Inertial Projection-Type Methods for Solving Quasi-Variational
Inequalities in Real Hilbert Spaces.” Journal of Optimization Theory and Applications,
vol. 184, Springer Nature, 2020, pp. 877–894, doi:10.1007/s10957-019-01616-6.
short: Y. Shehu, A. Gibali, S. Sagratella, Journal of Optimization Theory and Applications
184 (2020) 877–894.
date_created: 2019-12-09T21:33:44Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2023-09-06T11:27:15Z
day: '01'
ddc:
- '518'
- '510'
- '515'
department:
- _id: VlKo
doi: 10.1007/s10957-019-01616-6
ec_funded: 1
external_id:
isi:
- '000511805200009'
file:
- access_level: open_access
checksum: 9f6dc6c6bf2b48cb3a2091a9ed5feaf2
content_type: application/pdf
creator: dernst
date_created: 2020-10-12T10:40:27Z
date_updated: 2021-03-16T23:30:04Z
embargo: 2021-03-15
file_id: '8647'
file_name: 2020_JourOptimizationTheoryApplic_Shehu.pdf
file_size: 332641
relation: main_file
file_date_updated: 2021-03-16T23:30:04Z
has_accepted_license: '1'
intvolume: ' 184'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 877–894
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '616160'
name: 'Discrete Optimization in Computer Vision: Theory and Practice'
publication: Journal of Optimization Theory and Applications
publication_identifier:
eissn:
- 1573-2878
issn:
- 0022-3239
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inertial projection-type methods for solving quasi-variational inequalities
in real Hilbert spaces
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 184
year: '2020'
...
---
_id: '7652'
abstract:
- lang: eng
text: Organisms cope with change by taking advantage of transcriptional regulators.
However, when faced with rare environments, the evolution of transcriptional regulators
and their promoters may be too slow. Here, we investigate whether the intrinsic
instability of gene duplication and amplification provides a generic alternative
to canonical gene regulation. Using real-time monitoring of gene-copy-number mutations
in Escherichia coli, we show that gene duplications and amplifications enable
adaptation to fluctuating environments by rapidly generating copy-number and,
therefore, expression-level polymorphisms. This amplification-mediated gene expression
tuning (AMGET) occurs on timescales that are similar to canonical gene regulation
and can respond to rapid environmental changes. Mathematical modelling shows that
amplifications also tune gene expression in stochastic environments in which transcription-factor-based
schemes are hard to evolve or maintain. The fleeting nature of gene amplifications
gives rise to a generic population-level mechanism that relies on genetic heterogeneity
to rapidly tune the expression of any gene, without leaving any genomic signature.
acknowledgement: We thank L. Hurst, N. Barton, M. Pleska, M. Steinrück, B. Kavcic
and A. Staron for input on the manuscript, and To. Bergmiller and R. Chait for help
with microfluidics experiments. I.T. is a recipient the OMV fellowship. R.G. is
a recipient of a DOC (Doctoral Fellowship Programme of the Austrian Academy of Sciences)
Fellowship of the Austrian Academy of Sciences.
article_processing_charge: No
article_type: original
author:
- first_name: Isabella
full_name: Tomanek, Isabella
id: 3981F020-F248-11E8-B48F-1D18A9856A87
last_name: Tomanek
orcid: 0000-0001-6197-363X
- first_name: Rok
full_name: Grah, Rok
id: 483E70DE-F248-11E8-B48F-1D18A9856A87
last_name: Grah
orcid: 0000-0003-2539-3560
- first_name: M.
full_name: Lagator, M.
last_name: Lagator
- first_name: A. M. C.
full_name: Andersson, A. M. C.
last_name: Andersson
- first_name: Jonathan P
full_name: Bollback, Jonathan P
id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
last_name: Bollback
orcid: 0000-0002-4624-4612
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
citation:
ama: Tomanek I, Grah R, Lagator M, et al. Gene amplification as a form of population-level
gene expression regulation. Nature Ecology & Evolution. 2020;4(4):612-625.
doi:10.1038/s41559-020-1132-7
apa: Tomanek, I., Grah, R., Lagator, M., Andersson, A. M. C., Bollback, J. P., Tkačik,
G., & Guet, C. C. (2020). Gene amplification as a form of population-level
gene expression regulation. Nature Ecology & Evolution. Springer Nature.
https://doi.org/10.1038/s41559-020-1132-7
chicago: Tomanek, Isabella, Rok Grah, M. Lagator, A. M. C. Andersson, Jonathan P
Bollback, Gašper Tkačik, and Calin C Guet. “Gene Amplification as a Form of Population-Level
Gene Expression Regulation.” Nature Ecology & Evolution. Springer Nature,
2020. https://doi.org/10.1038/s41559-020-1132-7.
ieee: I. Tomanek et al., “Gene amplification as a form of population-level
gene expression regulation,” Nature Ecology & Evolution, vol. 4, no.
4. Springer Nature, pp. 612–625, 2020.
ista: Tomanek I, Grah R, Lagator M, Andersson AMC, Bollback JP, Tkačik G, Guet CC.
2020. Gene amplification as a form of population-level gene expression regulation.
Nature Ecology & Evolution. 4(4), 612–625.
mla: Tomanek, Isabella, et al. “Gene Amplification as a Form of Population-Level
Gene Expression Regulation.” Nature Ecology & Evolution, vol. 4, no.
4, Springer Nature, 2020, pp. 612–25, doi:10.1038/s41559-020-1132-7.
short: I. Tomanek, R. Grah, M. Lagator, A.M.C. Andersson, J.P. Bollback, G. Tkačik,
C.C. Guet, Nature Ecology & Evolution 4 (2020) 612–625.
date_created: 2020-04-08T15:20:53Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2024-03-27T23:30:36Z
day: '01'
ddc:
- '570'
department:
- _id: GaTk
- _id: CaGu
doi: 10.1038/s41559-020-1132-7
external_id:
isi:
- '000519008300005'
file:
- access_level: open_access
checksum: ef3bbf42023e30b2c24a6278025d2040
content_type: application/pdf
creator: dernst
date_created: 2020-10-09T09:56:01Z
date_updated: 2020-10-09T09:56:01Z
file_id: '8640'
file_name: 2020_NatureEcolEvo_Tomanek.pdf
file_size: 745242
relation: main_file
success: 1
file_date_updated: 2020-10-09T09:56:01Z
has_accepted_license: '1'
intvolume: ' 4'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Submitted Version
page: 612-625
project:
- _id: 267C84F4-B435-11E9-9278-68D0E5697425
name: Biophysically realistic genotype-phenotype maps for regulatory networks
publication: Nature Ecology & Evolution
publication_identifier:
issn:
- 2397-334X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/how-to-thrive-without-gene-regulation/
record:
- id: '8155'
relation: dissertation_contains
status: public
- id: '7383'
relation: research_data
status: public
- id: '7016'
relation: research_data
status: public
- id: '8653'
relation: used_in_publication
status: public
scopus_import: '1'
status: public
title: Gene amplification as a form of population-level gene expression regulation
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 4
year: '2020'
...
---
_id: '7258'
abstract:
- lang: eng
text: Many flows encountered in nature and applications are characterized by a chaotic
motion known as turbulence. Turbulent flows generate intense friction with pipe
walls and are responsible for considerable amounts of energy losses at world scale.
The nature of turbulent friction and techniques aimed at reducing it have been
subject of extensive research over the last century, but no definite answer has
been found yet. In this thesis we show that in pipes at moderate turbulent Reynolds
numbers friction is better described by the power law first introduced by Blasius
and not by the Prandtl–von Kármán formula. At higher Reynolds numbers, large scale
motions gradually become more important in the flow and can be related to the
change in scaling of friction. Next, we present a series of new techniques that
can relaminarize turbulence by suppressing a key mechanism that regenerates it
at walls, the lift–up effect. In addition, we investigate the process of turbulence
decay in several experiments and discuss the drag reduction potential. Finally,
we examine the behavior of friction under pulsating conditions inspired by the
human heart cycle and we show that under such circumstances turbulent friction
can be reduced to produce energy savings.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Davide
full_name: Scarselli, Davide
id: 40315C30-F248-11E8-B48F-1D18A9856A87
last_name: Scarselli
orcid: 0000-0001-5227-4271
citation:
ama: Scarselli D. New approaches to reduce friction in turbulent pipe flow. 2020.
doi:10.15479/AT:ISTA:7258
apa: Scarselli, D. (2020). New approaches to reduce friction in turbulent pipe
flow. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7258
chicago: Scarselli, Davide. “New Approaches to Reduce Friction in Turbulent Pipe
Flow.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:7258.
ieee: D. Scarselli, “New approaches to reduce friction in turbulent pipe flow,”
Institute of Science and Technology Austria, 2020.
ista: Scarselli D. 2020. New approaches to reduce friction in turbulent pipe flow.
Institute of Science and Technology Austria.
mla: Scarselli, Davide. New Approaches to Reduce Friction in Turbulent Pipe Flow.
Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:7258.
short: D. Scarselli, New Approaches to Reduce Friction in Turbulent Pipe Flow, Institute
of Science and Technology Austria, 2020.
date_created: 2020-01-12T16:07:26Z
date_published: 2020-01-13T00:00:00Z
date_updated: 2023-09-15T12:20:08Z
day: '13'
ddc:
- '532'
degree_awarded: PhD
department:
- _id: BjHo
doi: 10.15479/AT:ISTA:7258
ec_funded: 1
file:
- access_level: closed
checksum: 4df1ab24e9896635106adde5a54615bf
content_type: application/zip
creator: dscarsel
date_created: 2020-01-12T15:57:14Z
date_updated: 2021-01-13T23:30:05Z
embargo_to: open_access
file_id: '7259'
file_name: 2020_Scarselli_Thesis.zip
file_size: 26640830
relation: source_file
- access_level: open_access
checksum: 48659ab98e3414293c7a721385c2fd1c
content_type: application/pdf
creator: dscarsel
date_created: 2020-01-12T15:56:14Z
date_updated: 2021-01-13T23:30:05Z
embargo: 2021-01-12
file_id: '7260'
file_name: 2020_Scarselli_Thesis.pdf
file_size: 8515844
relation: main_file
file_date_updated: 2021-01-13T23:30:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: None
page: '174'
project:
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '306589'
name: Decoding the complexity of turbulence at its origin
- _id: 25104D44-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '737549'
name: Eliminating turbulence in oil pipelines
- _id: 25136C54-B435-11E9-9278-68D0E5697425
grant_number: HO 4393/1-2
name: Experimental studies of the turbulence transition and transport processes
in turbulent Taylor-Couette currents
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '6228'
relation: part_of_dissertation
status: public
- id: '6486'
relation: part_of_dissertation
status: public
- id: '461'
relation: part_of_dissertation
status: public
- id: '422'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
title: New approaches to reduce friction in turbulent pipe flow
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '8653'
abstract:
- lang: eng
text: "Mutations are the raw material of evolution and come in many different flavors.
Point mutations change a single letter in the DNA sequence, while copy number
mutations like duplications or deletions add or remove many letters of the DNA
sequence simultaneously. Each type of mutation exhibits specific properties like
its rate of formation and reversal. \r\nGene expression is a fundamental phenotype
that can be altered by both, point and copy number mutations. The following thesis
is concerned with the dynamics of gene expression evolution and how it is affected
by the properties exhibited by point and copy number mutations. Specifically,
we are considering i) copy number mutations during adaptation to fluctuating environments
and ii) the interaction of copy number and point mutations during adaptation to
constant environments. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Isabella
full_name: Tomanek, Isabella
id: 3981F020-F248-11E8-B48F-1D18A9856A87
last_name: Tomanek
orcid: 0000-0001-6197-363X
citation:
ama: Tomanek I. The evolution of gene expression by copy number and point mutations.
2020. doi:10.15479/AT:ISTA:8653
apa: Tomanek, I. (2020). The evolution of gene expression by copy number and
point mutations. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8653
chicago: Tomanek, Isabella. “The Evolution of Gene Expression by Copy Number and
Point Mutations.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8653.
ieee: I. Tomanek, “The evolution of gene expression by copy number and point mutations,”
Institute of Science and Technology Austria, 2020.
ista: Tomanek I. 2020. The evolution of gene expression by copy number and point
mutations. Institute of Science and Technology Austria.
mla: Tomanek, Isabella. The Evolution of Gene Expression by Copy Number and Point
Mutations. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8653.
short: I. Tomanek, The Evolution of Gene Expression by Copy Number and Point Mutations,
Institute of Science and Technology Austria, 2020.
date_created: 2020-10-13T13:02:33Z
date_published: 2020-10-13T00:00:00Z
date_updated: 2023-09-07T13:22:42Z
day: '13'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:8653
file:
- access_level: closed
checksum: c01d9f59794b4b70528f37637c17ad02
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: itomanek
date_created: 2020-10-16T12:14:21Z
date_updated: 2021-10-20T22:30:03Z
embargo_to: open_access
file_id: '8666'
file_name: Thesis_ITomanek_final_201016.docx
file_size: 25131884
relation: source_file
- access_level: open_access
checksum: f8edbc3b0f81a780e13ca1e561d42d8b
content_type: application/pdf
creator: itomanek
date_created: 2020-10-16T12:14:21Z
date_updated: 2021-10-20T22:30:03Z
embargo: 2021-10-19
file_id: '8667'
file_name: Thesis_ITomanek_final_201016.pdf
file_size: 15405675
relation: main_file
file_date_updated: 2021-10-20T22:30:03Z
has_accepted_license: '1'
keyword:
- duplication
- amplification
- promoter
- CNV
- AMGET
- experimental evolution
- Escherichia coli
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '117'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7652'
relation: research_data
status: public
status: public
supervisor:
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
title: The evolution of gene expression by copy number and point mutations
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '7427'
abstract:
- lang: eng
text: Plants, like other multicellular organisms, survive through a delicate balance
between growth and defense against pathogens. Salicylic acid (SA) is a major defense
signal in plants, and the perception mechanism as well as downstream signaling
activating the immune response are known. Here, we identify a parallel SA signaling
that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase
2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin
transporter is hyperphosphorylated in response to SA, leading to changed activity
of this important growth regulator. Accordingly, auxin transport and auxin-mediated
root development, including growth, gravitropic response, and lateral root organogenesis,
are inhibited. This study reveals how SA, besides activating immunity, concomitantly
attenuates growth through crosstalk with the auxin distribution network. Further
analysis of this dual role of SA and characterization of additional SA-regulated
PP2A targets will provide further insights into mechanisms maintaining a balance
between growth and defense.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: "We thank Shigeyuki Betsuyaku (University of Tsukuba), Alison Delong
(Brown University), Xinnian Dong (Duke University), Dolf Weijers (Wageningen University),
Yuelin Zhang (UBC), and Martine Pastuglia (Institut Jean-Pierre Bourgin) for sharing
published materials; Jana Riederer for help with cantharidin physiological analysis;
David Domjan for help with cloning pET28a-PIN2HL; Qing Lu for help with DARTS; Hana
Kozubı´kova´ for technical support on SA derivative synthesis; Zuzana Vondra´ kova´
for technical support with tobacco cells; Lucia Strader (Washington University),
Bert De Rybel (Ghent University), Bartel Vanholme (Ghent University), and Lukas
Mach (BOKU) for helpful discussions; and bioimaging and life science facilities
of IST Austria for continuous support. We gratefully acknowledge the Nottingham
Arabidopsis Stock Center (NASC) for providing T-DNA insertional mutants. The DSC
and SPR instruments were provided by the EQ-BOKU VIBT GmbH and the BOKU Core Facility
for Biomolecular and Cellular Analysis, with help of Irene Schaffner. The research
leading to these results has received funding from the European Union’s Horizon
2020 program (ERC grant agreement no. 742985 to J.F.) and the People Programme (Marie
Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013)
under REA grant agreement no. 291734. S.T. was supported by a European Molecular
Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 723-2015). O.N.
was supported by the Ministry of Education, Youth and Sports of the Czech Republic
(European Regional Development Fund-Project ‘‘Centre for Experimental Plant Biology’’
no. CZ.02.1.01/0.0/0.0/16_019/0000738). J. Pospısil was supported by European Regional
Development Fund Project ‘‘Centre for Experimental Plant Biology’’\r\n(no. CZ.02.1.01/0.0/0.0/16_019/0000738).
J. Petrasek was supported by EU Operational Programme Prague-Competitiveness (no.
CZ.2.16/3.1.00/21519). "
article_processing_charge: No
article_type: original
author:
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Melinda F
full_name: Abas, Melinda F
id: 3CFB3B1C-F248-11E8-B48F-1D18A9856A87
last_name: Abas
- first_name: Inge
full_name: Verstraeten, Inge
id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
last_name: Verstraeten
orcid: 0000-0001-7241-2328
- first_name: Matous
full_name: Glanc, Matous
id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
last_name: Glanc
orcid: 0000-0003-0619-7783
- first_name: Gergely
full_name: Molnar, Gergely
id: 34F1AF46-F248-11E8-B48F-1D18A9856A87
last_name: Molnar
- first_name: Jakub
full_name: Hajny, Jakub
id: 4800CC20-F248-11E8-B48F-1D18A9856A87
last_name: Hajny
orcid: 0000-0003-2140-7195
- first_name: Pavel
full_name: Lasák, Pavel
last_name: Lasák
- first_name: Ivan
full_name: Petřík, Ivan
last_name: Petřík
- first_name: Eugenia
full_name: Russinova, Eugenia
last_name: Russinova
- first_name: Jan
full_name: Petrášek, Jan
last_name: Petrášek
- first_name: Ondřej
full_name: Novák, Ondřej
last_name: Novák
- first_name: Jiří
full_name: Pospíšil, Jiří
last_name: Pospíšil
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Tan S, Abas MF, Verstraeten I, et al. Salicylic acid targets protein phosphatase
2A to attenuate growth in plants. Current Biology. 2020;30(3):381-395.e8.
doi:10.1016/j.cub.2019.11.058
apa: Tan, S., Abas, M. F., Verstraeten, I., Glanc, M., Molnar, G., Hajny, J., …
Friml, J. (2020). Salicylic acid targets protein phosphatase 2A to attenuate growth
in plants. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2019.11.058
chicago: Tan, Shutang, Melinda F Abas, Inge Verstraeten, Matous Glanc, Gergely Molnar,
Jakub Hajny, Pavel Lasák, et al. “Salicylic Acid Targets Protein Phosphatase 2A
to Attenuate Growth in Plants.” Current Biology. Cell Press, 2020. https://doi.org/10.1016/j.cub.2019.11.058.
ieee: S. Tan et al., “Salicylic acid targets protein phosphatase 2A to attenuate
growth in plants,” Current Biology, vol. 30, no. 3. Cell Press, p. 381–395.e8,
2020.
ista: Tan S, Abas MF, Verstraeten I, Glanc M, Molnar G, Hajny J, Lasák P, Petřík
I, Russinova E, Petrášek J, Novák O, Pospíšil J, Friml J. 2020. Salicylic acid
targets protein phosphatase 2A to attenuate growth in plants. Current Biology.
30(3), 381–395.e8.
mla: Tan, Shutang, et al. “Salicylic Acid Targets Protein Phosphatase 2A to Attenuate
Growth in Plants.” Current Biology, vol. 30, no. 3, Cell Press, 2020, p.
381–395.e8, doi:10.1016/j.cub.2019.11.058.
short: S. Tan, M.F. Abas, I. Verstraeten, M. Glanc, G. Molnar, J. Hajny, P. Lasák,
I. Petřík, E. Russinova, J. Petrášek, O. Novák, J. Pospíšil, J. Friml, Current
Biology 30 (2020) 381–395.e8.
date_created: 2020-02-02T23:01:00Z
date_published: 2020-02-03T00:00:00Z
date_updated: 2024-03-27T23:30:37Z
day: '03'
ddc:
- '580'
department:
- _id: JiFr
- _id: EvBe
doi: 10.1016/j.cub.2019.11.058
ec_funded: 1
external_id:
isi:
- '000511287900018'
pmid:
- '31956021'
file:
- access_level: open_access
checksum: 16f7d51fe28f91c21e4896a2028df40b
content_type: application/pdf
creator: dernst
date_created: 2020-09-22T09:51:28Z
date_updated: 2020-09-22T09:51:28Z
file_id: '8555'
file_name: 2020_CurrentBiology_Tan.pdf
file_size: 5360135
relation: main_file
success: 1
file_date_updated: 2020-09-22T09:51:28Z
has_accepted_license: '1'
intvolume: ' 30'
isi: 1
issue: '3'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 381-395.e8
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 256FEF10-B435-11E9-9278-68D0E5697425
grant_number: 723-2015
name: Long Term Fellowship
publication: Current Biology
publication_identifier:
issn:
- '09609822'
publication_status: published
publisher: Cell Press
quality_controlled: '1'
related_material:
record:
- id: '8822'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Salicylic acid targets protein phosphatase 2A to attenuate growth in plants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 30
year: '2020'
...
---
_id: '7500'
abstract:
- lang: eng
text: "Plant survival depends on vascular tissues, which originate in a self‐organizing
manner as strands of cells co‐directionally transporting the plant hormone auxin.
The latter phenomenon (also known as auxin canalization) is classically hypothesized
to be regulated by auxin itself via the effect of this hormone on the polarity
of its own intercellular transport. Correlative observations supported this concept,
but molecular insights remain limited.\r\nIn the current study, we established
an experimental system based on the model Arabidopsis thaliana, which exhibits
auxin transport channels and formation of vasculature strands in response to local
auxin application.\r\nOur methodology permits the genetic analysis of auxin canalization
under controllable experimental conditions. By utilizing this opportunity, we
confirmed the dependence of auxin canalization on a PIN‐dependent auxin transport
and nuclear, TIR1/AFB‐mediated auxin signaling. We also show that leaf venation
and auxin‐mediated PIN repolarization in the root require TIR1/AFB signaling.\r\nFurther
studies based on this experimental system are likely to yield better understanding
of the mechanisms underlying auxin transport polarization in other developmental
contexts."
acknowledgement: We thank Mark Estelle, José M. Alonso and the Arabidopsis Stock Centre
for providing seeds. We acknowledge the core facility CELLIM of CEITEC supported
by the MEYS CR (LM2015062 Czech‐BioImaging) and Plant Sciences Core Facility of
CEITEC Masaryk University for help in generating essential data. This project received
funding from the European Research Council (ERC) under the European Union's Horizon
2020 research and innovation program (grant agreement no. 742985) and the Czech
Science Foundation GAČR (GA13‐40637S and GA18‐26981S) to JF. JH is the recipient
of a DOC Fellowship of the Austrian Academy of Sciences at the Institute of Science
and Technology. The authors declare no competing interests.
article_processing_charge: No
article_type: original
author:
- first_name: E
full_name: Mazur, E
last_name: Mazur
- first_name: Ivan
full_name: Kulik, Ivan
id: F0AB3FCE-02D1-11E9-BD0E-99399A5D3DEB
last_name: Kulik
- first_name: Jakub
full_name: Hajny, Jakub
id: 4800CC20-F248-11E8-B48F-1D18A9856A87
last_name: Hajny
orcid: 0000-0003-2140-7195
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Mazur E, Kulik I, Hajny J, Friml J. Auxin canalization and vascular tissue
formation by TIR1/AFB-mediated auxin signaling in arabidopsis. New Phytologist.
2020;226(5):1375-1383. doi:10.1111/nph.16446
apa: Mazur, E., Kulik, I., Hajny, J., & Friml, J. (2020). Auxin canalization
and vascular tissue formation by TIR1/AFB-mediated auxin signaling in arabidopsis.
New Phytologist. Wiley. https://doi.org/10.1111/nph.16446
chicago: Mazur, E, Ivan Kulik, Jakub Hajny, and Jiří Friml. “Auxin Canalization
and Vascular Tissue Formation by TIR1/AFB-Mediated Auxin Signaling in Arabidopsis.”
New Phytologist. Wiley, 2020. https://doi.org/10.1111/nph.16446.
ieee: E. Mazur, I. Kulik, J. Hajny, and J. Friml, “Auxin canalization and vascular
tissue formation by TIR1/AFB-mediated auxin signaling in arabidopsis,” New
Phytologist, vol. 226, no. 5. Wiley, pp. 1375–1383, 2020.
ista: Mazur E, Kulik I, Hajny J, Friml J. 2020. Auxin canalization and vascular
tissue formation by TIR1/AFB-mediated auxin signaling in arabidopsis. New Phytologist.
226(5), 1375–1383.
mla: Mazur, E., et al. “Auxin Canalization and Vascular Tissue Formation by TIR1/AFB-Mediated
Auxin Signaling in Arabidopsis.” New Phytologist, vol. 226, no. 5, Wiley,
2020, pp. 1375–83, doi:10.1111/nph.16446.
short: E. Mazur, I. Kulik, J. Hajny, J. Friml, New Phytologist 226 (2020) 1375–1383.
date_created: 2020-02-18T10:03:47Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2024-03-27T23:30:37Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/nph.16446
ec_funded: 1
external_id:
isi:
- '000514939700001'
pmid:
- '31971254'
file:
- access_level: open_access
checksum: 17de728b0205979feb95ce663ba918c2
content_type: application/pdf
creator: dernst
date_created: 2020-11-20T09:32:10Z
date_updated: 2020-11-20T09:32:10Z
file_id: '8781'
file_name: 2020_NewPhytologist_Mazur.pdf
file_size: 2106888
relation: main_file
success: 1
file_date_updated: 2020-11-20T09:32:10Z
has_accepted_license: '1'
intvolume: ' 226'
isi: 1
issue: '5'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1375-1383
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 2699E3D2-B435-11E9-9278-68D0E5697425
grant_number: '25239'
name: Cell surface receptor complexes for PIN polarity and auxin-mediated development
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646x
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '8822'
relation: dissertation_contains
status: public
status: public
title: Auxin canalization and vascular tissue formation by TIR1/AFB-mediated auxin
signaling in arabidopsis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 226
year: '2020'
...
---
_id: '8822'
abstract:
- lang: eng
text: "Self-organization is a hallmark of plant development manifested e.g. by intricate
leaf vein patterns, flexible formation of vasculature during organogenesis or
its regeneration following wounding. Spontaneously arising channels transporting
the phytohormone auxin, created by coordinated polar localizations of PIN-FORMED
1 (PIN1) auxin exporter, provide positional cues for these as well as other plant
patterning processes. To find regulators acting downstream of auxin and the TIR1/AFB
auxin signaling pathway essential for PIN1 coordinated polarization during auxin
canalization, we performed microarray experiments. Besides the known components
of general PIN polarity maintenance, such as PID and PIP5K kinases, we identified
and characterized a new regulator of auxin canalization, the transcription factor
WRKY DNA-BINDING PROTEIN 23 (WRKY23).\r\nNext, we designed a subsequent microarray
experiment to further uncover other molecular players, downstream of auxin-TIR1/AFB-WRKY23
involved in the regulation of auxin-mediated PIN repolarization. We identified
a novel and crucial part of the molecular machinery underlying auxin canalization.
The auxin-regulated malectin-type receptor-like kinase CAMEL and the associated
leucine-rich repeat receptor-like kinase CANAR target and directly phosphorylate
PIN auxin transporters. camel and canar mutants are impaired in PIN1 subcellular
trafficking and auxin-mediated repolarization leading to defects in auxin transport,
ultimately to leaf venation and vasculature regeneration defects. Our results
describe the CAMEL-CANAR receptor complex, which is required for auxin feed-back
on its own transport and thus for coordinated tissue polarization during auxin
canalization."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Jakub
full_name: Hajny, Jakub
id: 4800CC20-F248-11E8-B48F-1D18A9856A87
last_name: Hajny
orcid: 0000-0003-2140-7195
citation:
ama: Hajny J. Identification and characterization of the molecular machinery of
auxin-dependent canalization during vasculature formation and regeneration. 2020.
doi:10.15479/AT:ISTA:8822
apa: Hajny, J. (2020). Identification and characterization of the molecular machinery
of auxin-dependent canalization during vasculature formation and regeneration.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8822
chicago: Hajny, Jakub. “Identification and Characterization of the Molecular Machinery
of Auxin-Dependent Canalization during Vasculature Formation and Regeneration.”
Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8822.
ieee: J. Hajny, “Identification and characterization of the molecular machinery
of auxin-dependent canalization during vasculature formation and regeneration,”
Institute of Science and Technology Austria, 2020.
ista: Hajny J. 2020. Identification and characterization of the molecular machinery
of auxin-dependent canalization during vasculature formation and regeneration.
Institute of Science and Technology Austria.
mla: Hajny, Jakub. Identification and Characterization of the Molecular Machinery
of Auxin-Dependent Canalization during Vasculature Formation and Regeneration.
Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8822.
short: J. Hajny, Identification and Characterization of the Molecular Machinery
of Auxin-Dependent Canalization during Vasculature Formation and Regeneration,
Institute of Science and Technology Austria, 2020.
date_created: 2020-12-01T12:38:18Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2023-09-19T10:39:33Z
day: '01'
ddc:
- '580'
degree_awarded: PhD
department:
- _id: JiFr
doi: 10.15479/AT:ISTA:8822
file:
- access_level: closed
checksum: 210a9675af5e4c78b0b56d920ac82866
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: jhajny
date_created: 2020-12-04T07:27:52Z
date_updated: 2021-07-16T22:30:03Z
embargo_to: open_access
file_id: '8919'
file_name: Jakub Hajný IST Austria final_JH.docx
file_size: 91279806
relation: source_file
- access_level: open_access
checksum: 1781385b4aa73eba89cc76c6172f71d2
content_type: application/pdf
creator: jhajny
date_created: 2020-12-09T15:04:41Z
date_updated: 2021-12-08T23:30:03Z
embargo: 2021-12-07
file_id: '8933'
file_name: Jakub Hajný IST Austria final_JH-merged without Science.pdf
file_size: 68707697
relation: main_file
file_date_updated: 2021-12-08T23:30:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '249'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7427'
relation: part_of_dissertation
status: public
- id: '6260'
relation: part_of_dissertation
status: public
- id: '7500'
relation: part_of_dissertation
status: public
- id: '191'
relation: part_of_dissertation
status: public
- id: '449'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
title: Identification and characterization of the molecular machinery of auxin-dependent
canalization during vasculature formation and regeneration
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '8350'
abstract:
- lang: eng
text: "Cytoplasm is a gel-like crowded environment composed of tens of thousands
of macromolecules, organelles, cytoskeletal networks and cytosol. The structure
of the cytoplasm is thought to be highly organized and heterogeneous due to the
crowding of its constituents and their effective compartmentalization. In such
an environment, the diffusive dynamics of the molecules is very restricted, an
effect that is further amplified by clustering and anchoring of molecules. Despite
the jammed nature of the cytoplasm at the microscopic scale, large-scale reorganization
of cytoplasm is essential for important cellular functions, such as nuclear positioning
and cell division. How such mesoscale reorganization of the cytoplasm is achieved,
especially for very large cells such as oocytes or syncytial tissues that can
span hundreds of micrometers in size, has only begun to be understood.\r\nIn this
thesis, I focus on the recent advances in elucidating the molecular, cellular
and biophysical principles underlying cytoplasmic organization across different
scales, structures and species. First, I outline which of these principles have
been identified by reductionist approaches, such as in vitro reconstitution assays,
where boundary conditions and components can be modulated at ease. I then describe
how the theoretical and experimental framework established in these reduced systems
have been applied to their more complex in vivo counterparts, in particular oocytes
and embryonic syncytial structures, and discuss how such complex biological systems
can initiate symmetry breaking and establish patterning.\r\nSpecifically, I examine
an example of large-scale reorganizations taking place in zebrafish embryos, where
extensive cytoplasmic streaming leads to the segregation of cytoplasm from yolk
granules along the animal-vegetal axis of the embryo. Using biophysical experimentation
and theory, I investigate the forces underlying this process, to show that this
process does not rely on cortical actin reorganization, as previously thought,
but instead on a cell-cycle-dependent bulk actin polymerization wave traveling
from the animal to the vegetal pole of the embryo. This wave functions in segregation
by both pulling cytoplasm animally and pushing yolk granules vegetally. Cytoplasm
pulling is mediated by bulk actin network flows exerting friction forces on the
cytoplasm, while yolk granule pushing is achieved by a mechanism closely resembling
actin comet formation on yolk granules. This study defines a novel role of bulk
actin polymerization waves in embryo polarization via cytoplasmic segregation.
Lastly, I describe the cytoplasmic reorganizations taking place during zebrafish
oocyte maturation, where the initial segregation of the cytoplasm and yolk granules
occurs. Here, I demonstrate a previously uncharacterized wave of microtubule aster
formation, traveling the oocyte along the animal-vegetal axis. Further research
is required to determine the role of such microtubule structures in cytoplasmic
reorganizations therein.\r\nCollectively, these studies provide further evidence
for the coupling between cell cytoskeleton and cell cycle machinery, which can
underlie a core self-organizing mechanism for orchestrating large-scale reorganizations
in a cell-cycle-tunable manner, where the modulations of the force-generating
machinery and cytoplasmic mechanics can be harbored to fulfill cellular functions."
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: EM-Fac
acknowledgement: "I would have had no fish and hence no results without our wonderful
fish facility crew, Verena Mayer, Eva Schlegl, Andreas Mlak and Matthias Nowak.
Special thanks to Verena for being always happy to help and dealing with our chaotic
schedules in the lab. Danke auch, Verena, für deine Geduld, mit mir auf Deutsch
zu sprechen. Das hat mir sehr geholfen.\r\nSpecial thanks to the Bioimaging and
EM facilities at IST Austria for supporting us every day. Very special thanks would
go to Robert Hauschild for his continuous support on data analysis and also to Jack
Merrin for designing and building microfabricated chambers for the project and for
the various discussions on making zebrafish extracts."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Shayan
full_name: Shamipour, Shayan
id: 40B34FE2-F248-11E8-B48F-1D18A9856A87
last_name: Shamipour
citation:
ama: Shamipour S. Bulk actin dynamics drive phase segregation in zebrafish oocytes
. 2020. doi:10.15479/AT:ISTA:8350
apa: Shamipour, S. (2020). Bulk actin dynamics drive phase segregation in zebrafish
oocytes . Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8350
chicago: Shamipour, Shayan. “Bulk Actin Dynamics Drive Phase Segregation in Zebrafish
Oocytes .” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8350.
ieee: S. Shamipour, “Bulk actin dynamics drive phase segregation in zebrafish oocytes
,” Institute of Science and Technology Austria, 2020.
ista: Shamipour S. 2020. Bulk actin dynamics drive phase segregation in zebrafish
oocytes . Institute of Science and Technology Austria.
mla: Shamipour, Shayan. Bulk Actin Dynamics Drive Phase Segregation in Zebrafish
Oocytes . Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8350.
short: S. Shamipour, Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes
, Institute of Science and Technology Austria, 2020.
date_created: 2020-09-09T11:12:10Z
date_published: 2020-09-09T00:00:00Z
date_updated: 2023-09-27T14:16:45Z
day: '09'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: BjHo
- _id: CaHe
doi: 10.15479/AT:ISTA:8350
file:
- access_level: closed
checksum: 6e47871c74f85008b9876112eb3fcfa1
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: sshamip
date_created: 2020-09-09T11:06:27Z
date_updated: 2021-09-11T22:30:05Z
embargo_to: open_access
file_id: '8351'
file_name: Shayan-Thesis-Final.docx
file_size: 65194814
relation: source_file
- access_level: open_access
checksum: 1b44c57f04d7e8a6fe41b1c9c55a52a3
content_type: application/pdf
creator: sshamip
date_created: 2020-09-09T11:06:13Z
date_updated: 2021-09-11T22:30:05Z
embargo: 2021-09-10
file_id: '8352'
file_name: Shayan-Thesis-Final.pdf
file_size: 23729605
relation: main_file
file_date_updated: 2021-09-11T22:30:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: None
page: '107'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '661'
relation: part_of_dissertation
status: public
- id: '6508'
relation: part_of_dissertation
status: public
- id: '7001'
relation: part_of_dissertation
status: public
- id: '735'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
title: 'Bulk actin dynamics drive phase segregation in zebrafish oocytes '
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '8569'
abstract:
- lang: eng
text: Concerted radial migration of newly born cortical projection neurons, from
their birthplace to their final target lamina, is a key step in the assembly of
the cerebral cortex. The cellular and molecular mechanisms regulating the specific
sequential steps of radial neuronal migration in vivo are however still unclear,
let alone the effects and interactions with the extracellular environment. In
any in vivo context, cells will always be exposed to a complex extracellular environment
consisting of (1) secreted factors acting as potential signaling cues, (2) the
extracellular matrix, and (3) other cells providing cell–cell interaction through
receptors and/or direct physical stimuli. Most studies so far have described and
focused mainly on intrinsic cell-autonomous gene functions in neuronal migration
but there is accumulating evidence that non-cell-autonomous-, local-, systemic-,
and/or whole tissue-wide effects substantially contribute to the regulation of
radial neuronal migration. These non-cell-autonomous effects may differentially
affect cortical neuron migration in distinct cellular environments. However, the
cellular and molecular natures of such non-cell-autonomous mechanisms are mostly
unknown. Furthermore, physical forces due to collective migration and/or community
effects (i.e., interactions with surrounding cells) may play important roles in
neocortical projection neuron migration. In this concise review, we first outline
distinct models of non-cell-autonomous interactions of cortical projection neurons
along their radial migration trajectory during development. We then summarize
experimental assays and platforms that can be utilized to visualize and potentially
probe non-cell-autonomous mechanisms. Lastly, we define key questions to address
in the future.
acknowledgement: AH was a recipient of a DOC Fellowship (24812) of the Austrian Academy
of Sciences. This work also received support from IST Austria institutional funds;
the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework
Programme (FP7/2007–2013) under REA Grant Agreement No. 618444 to SH.
article_number: '574382'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Hansen AH, Hippenmeyer S. Non-cell-autonomous mechanisms in radial projection
neuron migration in the developing cerebral cortex. Frontiers in Cell and Developmental
Biology. 2020;8(9). doi:10.3389/fcell.2020.574382
apa: Hansen, A. H., & Hippenmeyer, S. (2020). Non-cell-autonomous mechanisms
in radial projection neuron migration in the developing cerebral cortex. Frontiers
in Cell and Developmental Biology. Frontiers. https://doi.org/10.3389/fcell.2020.574382
chicago: Hansen, Andi H, and Simon Hippenmeyer. “Non-Cell-Autonomous Mechanisms
in Radial Projection Neuron Migration in the Developing Cerebral Cortex.” Frontiers
in Cell and Developmental Biology. Frontiers, 2020. https://doi.org/10.3389/fcell.2020.574382.
ieee: A. H. Hansen and S. Hippenmeyer, “Non-cell-autonomous mechanisms in radial
projection neuron migration in the developing cerebral cortex,” Frontiers in
Cell and Developmental Biology, vol. 8, no. 9. Frontiers, 2020.
ista: Hansen AH, Hippenmeyer S. 2020. Non-cell-autonomous mechanisms in radial projection
neuron migration in the developing cerebral cortex. Frontiers in Cell and Developmental
Biology. 8(9), 574382.
mla: Hansen, Andi H., and Simon Hippenmeyer. “Non-Cell-Autonomous Mechanisms in
Radial Projection Neuron Migration in the Developing Cerebral Cortex.” Frontiers
in Cell and Developmental Biology, vol. 8, no. 9, 574382, Frontiers, 2020,
doi:10.3389/fcell.2020.574382.
short: A.H. Hansen, S. Hippenmeyer, Frontiers in Cell and Developmental Biology
8 (2020).
date_created: 2020-09-26T06:11:07Z
date_published: 2020-09-25T00:00:00Z
date_updated: 2024-03-27T23:30:40Z
day: '25'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.3389/fcell.2020.574382
ec_funded: 1
external_id:
isi:
- '000577915900001'
pmid:
- '33102480'
file:
- access_level: open_access
checksum: 01f731824194c94c81a5da360d997073
content_type: application/pdf
creator: dernst
date_created: 2020-09-28T13:11:17Z
date_updated: 2020-09-28T13:11:17Z
file_id: '8584'
file_name: 2020_Frontiers_Hansen.pdf
file_size: 5527139
relation: main_file
success: 1
file_date_updated: 2020-09-28T13:11:17Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2625A13E-B435-11E9-9278-68D0E5697425
grant_number: '24812'
name: Molecular Mechanisms of Radial Neuronal Migration
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618444'
name: Molecular Mechanisms of Cerebral Cortex Development
publication: Frontiers in Cell and Developmental Biology
publication_identifier:
issn:
- 2296-634X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
related_material:
record:
- id: '9962'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Non-cell-autonomous mechanisms in radial projection neuron migration in the
developing cerebral cortex
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 8
year: '2020'
...
---
_id: '7815'
abstract:
- lang: eng
text: Beginning from a limited pool of progenitors, the mammalian cerebral cortex
forms highly organized functional neural circuits. However, the underlying cellular
and molecular mechanisms regulating lineage transitions of neural stem cells (NSCs)
and eventual production of neurons and glia in the developing neuroepithelium
remains unclear. Methods to trace NSC division patterns and map the lineage of
clonally related cells have advanced dramatically. However, many contemporary
lineage tracing techniques suffer from the lack of cellular resolution of progeny
cell fate, which is essential for deciphering progenitor cell division patterns.
Presented is a protocol using mosaic analysis with double markers (MADM) to perform
in vivo clonal analysis. MADM concomitantly manipulates individual progenitor
cells and visualizes precise division patterns and lineage progression at unprecedented
single cell resolution. MADM-based interchromosomal recombination events during
the G2-X phase of mitosis, together with temporally inducible CreERT2, provide
exact information on the birth dates of clones and their division patterns. Thus,
MADM lineage tracing provides unprecedented qualitative and quantitative optical
readouts of the proliferation mode of stem cell progenitors at the single cell
level. MADM also allows for examination of the mechanisms and functional requirements
of candidate genes in NSC lineage progression. This method is unique in that comparative
analysis of control and mutant subclones can be performed in the same tissue environment
in vivo. Here, the protocol is described in detail, and experimental paradigms
to employ MADM for clonal analysis and lineage tracing in the developing cerebral
cortex are demonstrated. Importantly, this protocol can be adapted to perform
MADM clonal analysis in any murine stem cell niche, as long as the CreERT2 driver
is present.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
article_number: e61147
article_processing_charge: No
article_type: original
author:
- first_name: Robert J
full_name: Beattie, Robert J
id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
last_name: Beattie
orcid: 0000-0002-8483-8753
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Nicole
full_name: Amberg, Nicole
id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
last_name: Amberg
orcid: 0000-0002-3183-8207
- first_name: Giselle T
full_name: Cheung, Giselle T
id: 471195F6-F248-11E8-B48F-1D18A9856A87
last_name: Cheung
orcid: 0000-0001-8457-2572
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Beattie RJ, Streicher C, Amberg N, et al. Lineage tracing and clonal analysis
in developing cerebral cortex using mosaic analysis with double markers (MADM).
Journal of Visual Experiments. 2020;(159). doi:10.3791/61147
apa: Beattie, R. J., Streicher, C., Amberg, N., Cheung, G. T., Contreras, X., Hansen,
A. H., & Hippenmeyer, S. (2020). Lineage tracing and clonal analysis in developing
cerebral cortex using mosaic analysis with double markers (MADM). Journal of
Visual Experiments. MyJove Corporation. https://doi.org/10.3791/61147
chicago: Beattie, Robert J, Carmen Streicher, Nicole Amberg, Giselle T Cheung, Ximena
Contreras, Andi H Hansen, and Simon Hippenmeyer. “Lineage Tracing and Clonal Analysis
in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM).”
Journal of Visual Experiments. MyJove Corporation, 2020. https://doi.org/10.3791/61147.
ieee: R. J. Beattie et al., “Lineage tracing and clonal analysis in developing
cerebral cortex using mosaic analysis with double markers (MADM),” Journal
of Visual Experiments, no. 159. MyJove Corporation, 2020.
ista: Beattie RJ, Streicher C, Amberg N, Cheung GT, Contreras X, Hansen AH, Hippenmeyer
S. 2020. Lineage tracing and clonal analysis in developing cerebral cortex using
mosaic analysis with double markers (MADM). Journal of Visual Experiments. (159),
e61147.
mla: Beattie, Robert J., et al. “Lineage Tracing and Clonal Analysis in Developing
Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM).” Journal
of Visual Experiments, no. 159, e61147, MyJove Corporation, 2020, doi:10.3791/61147.
short: R.J. Beattie, C. Streicher, N. Amberg, G.T. Cheung, X. Contreras, A.H. Hansen,
S. Hippenmeyer, Journal of Visual Experiments (2020).
date_created: 2020-05-11T08:31:20Z
date_published: 2020-05-08T00:00:00Z
date_updated: 2024-03-27T23:30:41Z
day: '08'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.3791/61147
ec_funded: 1
external_id:
isi:
- '000546406600043'
file:
- access_level: open_access
checksum: 3154ea7f90b9fb45e084cd1c2770597d
content_type: application/pdf
creator: rbeattie
date_created: 2020-05-11T08:28:38Z
date_updated: 2020-07-14T12:48:03Z
file_id: '7816'
file_name: jove-protocol-61147-lineage-tracing-clonal-analysis-developing-cerebral-cortex-using.pdf
file_size: 1352186
relation: main_file
file_date_updated: 2020-07-14T12:48:03Z
has_accepted_license: '1'
isi: 1
issue: '159'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 264E56E2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02416
name: Molecular Mechanisms Regulating Gliogenesis in the Cerebral Cortex
- _id: 268F8446-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: T0101031
name: Role of Eed in neural stem cell lineage progression
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 2625A13E-B435-11E9-9278-68D0E5697425
grant_number: '24812'
name: Molecular Mechanisms of Radial Neuronal Migration
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Journal of Visual Experiments
publication_identifier:
issn:
- 1940-087X
publication_status: published
publisher: MyJove Corporation
quality_controlled: '1'
related_material:
record:
- id: '7902'
relation: part_of_dissertation
status: public
scopus_import: '1'
status: public
title: Lineage tracing and clonal analysis in developing cerebral cortex using mosaic
analysis with double markers (MADM)
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7902'
abstract:
- lang: eng
text: "Mosaic genetic analysis has been widely used in different model organisms
such as the fruit fly to study gene-function in a cell-autonomous or tissue-specific
fashion. More recently, and less easily conducted, mosaic genetic analysis in
mice has also been enabled with the ambition to shed light on human gene function
and disease. These genetic tools are of particular interest, but not restricted
to, the study of the brain. Notably, the MADM technology offers a genetic approach
in mice to visualize and concomitantly manipulate small subsets of genetically
defined cells at a clonal level and single cell resolution. MADM-based analysis
has already advanced the study of genetic mechanisms regulating brain development
and is expected that further MADM-based analysis of genetic alterations will continue
to reveal important insights on the fundamental principles of development and
disease to potentially assist in the development of new therapies or treatments.\r\nIn
summary, this work completed and characterized the necessary genome-wide genetic
tools to perform MADM-based analysis at single cell level of the vast majority
of mouse genes in virtually any cell type and provided a protocol to perform lineage
tracing using the novel MADM resource. Importantly, this work also explored and
revealed novel aspects of biologically relevant events in an in vivo context,
such as the chromosome-specific bias of chromatid sister segregation pattern,
the generation of cell-type diversity in the cerebral cortex and in the cerebellum
and finally, the relevance of the interplay between the cell-autonomous gene function
and cell-non-autonomous (community) effects in radial glial progenitor lineage
progression.\r\nThis work provides a foundation and opens the door to further
elucidating the molecular mechanisms underlying neuronal diversity and astrocyte
generation."
acknowledged_ssus:
- _id: PreCl
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
citation:
ama: Contreras X. Genetic dissection of neural development in health and disease
at single cell resolution. 2020. doi:10.15479/AT:ISTA:7902
apa: Contreras, X. (2020). Genetic dissection of neural development in health
and disease at single cell resolution. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:7902
chicago: Contreras, Ximena. “Genetic Dissection of Neural Development in Health
and Disease at Single Cell Resolution.” Institute of Science and Technology Austria,
2020. https://doi.org/10.15479/AT:ISTA:7902.
ieee: X. Contreras, “Genetic dissection of neural development in health and disease
at single cell resolution,” Institute of Science and Technology Austria, 2020.
ista: Contreras X. 2020. Genetic dissection of neural development in health and
disease at single cell resolution. Institute of Science and Technology Austria.
mla: Contreras, Ximena. Genetic Dissection of Neural Development in Health and
Disease at Single Cell Resolution. Institute of Science and Technology Austria,
2020, doi:10.15479/AT:ISTA:7902.
short: X. Contreras, Genetic Dissection of Neural Development in Health and Disease
at Single Cell Resolution, Institute of Science and Technology Austria, 2020.
date_created: 2020-05-29T08:27:32Z
date_published: 2020-06-05T00:00:00Z
date_updated: 2023-10-18T08:45:16Z
day: '05'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: SiHi
doi: 10.15479/AT:ISTA:7902
ec_funded: 1
file:
- access_level: closed
checksum: 43c172bf006c95b65992d473c7240d13
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: xcontreras
date_created: 2020-06-05T08:18:08Z
date_updated: 2021-06-07T22:30:03Z
embargo_to: open_access
file_id: '7927'
file_name: PhDThesis_Contreras.docx
file_size: 53134142
relation: source_file
- access_level: open_access
checksum: addfed9128271be05cae3608e03a6ec0
content_type: application/pdf
creator: xcontreras
date_created: 2020-06-05T08:18:07Z
date_updated: 2021-06-07T22:30:03Z
embargo: 2021-06-06
file_id: '7928'
file_name: PhDThesis_Contreras.pdf
file_size: 35117191
relation: main_file
file_date_updated: 2021-06-07T22:30:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '214'
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '6830'
relation: dissertation_contains
status: public
- id: '28'
relation: dissertation_contains
status: public
- id: '7815'
relation: dissertation_contains
status: public
status: public
supervisor:
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
title: Genetic dissection of neural development in health and disease at single cell
resolution
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8190'
article_number: e202007029
article_processing_charge: No
article_type: letter_note
author:
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Anna
full_name: Huttenlocher, Anna
last_name: Huttenlocher
citation:
ama: 'Sixt MK, Huttenlocher A. Zena Werb (1945-2020): Cell biology in context. The
Journal of Cell Biology. 2020;219(8). doi:10.1083/jcb.202007029'
apa: 'Sixt, M. K., & Huttenlocher, A. (2020). Zena Werb (1945-2020): Cell biology
in context. The Journal of Cell Biology. Rockefeller University Press.
https://doi.org/10.1083/jcb.202007029'
chicago: 'Sixt, Michael K, and Anna Huttenlocher. “Zena Werb (1945-2020): Cell Biology
in Context.” The Journal of Cell Biology. Rockefeller University Press,
2020. https://doi.org/10.1083/jcb.202007029.'
ieee: 'M. K. Sixt and A. Huttenlocher, “Zena Werb (1945-2020): Cell biology in context,”
The Journal of Cell Biology, vol. 219, no. 8. Rockefeller University Press,
2020.'
ista: 'Sixt MK, Huttenlocher A. 2020. Zena Werb (1945-2020): Cell biology in context.
The Journal of Cell Biology. 219(8), e202007029.'
mla: 'Sixt, Michael K., and Anna Huttenlocher. “Zena Werb (1945-2020): Cell Biology
in Context.” The Journal of Cell Biology, vol. 219, no. 8, e202007029,
Rockefeller University Press, 2020, doi:10.1083/jcb.202007029.'
short: M.K. Sixt, A. Huttenlocher, The Journal of Cell Biology 219 (2020).
date_created: 2020-08-02T22:00:57Z
date_published: 2020-07-22T00:00:00Z
date_updated: 2023-10-17T10:04:49Z
day: '22'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1083/jcb.202007029
external_id:
isi:
- '000573631000004'
file:
- access_level: open_access
checksum: 30016d778d266b8e17d01094917873b8
content_type: application/pdf
creator: dernst
date_created: 2020-08-04T13:11:52Z
date_updated: 2021-02-02T23:30:03Z
embargo: 2021-02-01
file_id: '8200'
file_name: 2020_JCB_Sixt.pdf
file_size: 830725
relation: main_file
file_date_updated: 2021-02-02T23:30:03Z
has_accepted_license: '1'
intvolume: ' 219'
isi: 1
issue: '8'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: The Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
publication_status: published
publisher: Rockefeller University Press
scopus_import: '1'
status: public
title: 'Zena Werb (1945-2020): Cell biology in context'
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 219
year: '2020'
...
---
_id: '8986'
abstract:
- lang: eng
text: 'Flowering plants display the highest diversity among plant species and have
notably shaped terrestrial landscapes. Nonetheless, the evolutionary origin of
their unprecedented morphological complexity remains largely an enigma. Here,
we show that the coevolution of cis-regulatory and coding regions of PIN-FORMED
(PIN) auxin transporters confined their expression to certain cell types and directed
their subcellular localization to particular cell sides, which together enabled
dynamic auxin gradients across tissues critical to the complex architecture of
flowering plants. Extensive intraspecies and interspecies genetic complementation
experiments with PINs from green alga up to flowering plant lineages showed that
PIN genes underwent three subsequent, critical evolutionary innovations and thus
acquired a triple function to regulate the development of three essential components
of the flowering plant Arabidopsis: shoot/root, inflorescence, and floral organ.
Our work highlights the critical role of functional innovations within the PIN
gene family as essential prerequisites for the origin of flowering plants.'
acknowledgement: 'We thank C.Löhne (Botanic Gardens, University of Bonn) for providing
us with A. trichopoda. We would like to thank T.Han, A.Mally (IST, Austria), and
C.Hartinger (University of Oxford) for constructive comment and careful reading.
Funding: The research leading to these results has received funding from the European
Union’s Horizon 2020 Research and Innovation Programme (ERC grant agreement number
742985), Austrian Science Fund (FWF, grant number I 3630-B25), DOC Fellowship of
the Austrian Academy of Sciences, and IST Fellow program. '
article_number: eabc8895
article_processing_charge: No
article_type: original
author:
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: Lesia
full_name: Rodriguez Solovey, Lesia
id: 3922B506-F248-11E8-B48F-1D18A9856A87
last_name: Rodriguez Solovey
orcid: 0000-0002-7244-7237
- first_name: Lanxin
full_name: Li, Lanxin
id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0002-5607-272X
- first_name: Xixi
full_name: Zhang, Xixi
id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
last_name: Zhang
orcid: 0000-0001-7048-4627
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. Functional innovations
of PIN auxin transporters mark crucial evolutionary transitions during rise of
flowering plants. Science Advances. 2020;6(50). doi:10.1126/sciadv.abc8895
apa: Zhang, Y., Rodriguez Solovey, L., Li, L., Zhang, X., & Friml, J. (2020).
Functional innovations of PIN auxin transporters mark crucial evolutionary transitions
during rise of flowering plants. Science Advances. AAAS. https://doi.org/10.1126/sciadv.abc8895
chicago: Zhang, Yuzhou, Lesia Rodriguez Solovey, Lanxin Li, Xixi Zhang, and Jiří
Friml. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary
Transitions during Rise of Flowering Plants.” Science Advances. AAAS, 2020.
https://doi.org/10.1126/sciadv.abc8895.
ieee: Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, and J. Friml, “Functional
innovations of PIN auxin transporters mark crucial evolutionary transitions during
rise of flowering plants,” Science Advances, vol. 6, no. 50. AAAS, 2020.
ista: Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. 2020. Functional innovations
of PIN auxin transporters mark crucial evolutionary transitions during rise of
flowering plants. Science Advances. 6(50), eabc8895.
mla: Zhang, Yuzhou, et al. “Functional Innovations of PIN Auxin Transporters Mark
Crucial Evolutionary Transitions during Rise of Flowering Plants.” Science
Advances, vol. 6, no. 50, eabc8895, AAAS, 2020, doi:10.1126/sciadv.abc8895.
short: Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, J. Friml, Science Advances
6 (2020).
date_created: 2021-01-03T23:01:23Z
date_published: 2020-12-11T00:00:00Z
date_updated: 2024-03-27T23:30:43Z
day: '11'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1126/sciadv.abc8895
ec_funded: 1
external_id:
isi:
- '000599903600014'
pmid:
- '33310852'
file:
- access_level: open_access
checksum: 5ac2500b191c08ef6dab5327f40ff663
content_type: application/pdf
creator: dernst
date_created: 2021-01-07T12:44:33Z
date_updated: 2021-01-07T12:44:33Z
file_id: '8994'
file_name: 2020_ScienceAdvances_Zhang.pdf
file_size: 10578145
relation: main_file
success: 1
file_date_updated: 2021-01-07T12:44:33Z
has_accepted_license: '1'
intvolume: ' 6'
isi: 1
issue: '50'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 26B4D67E-B435-11E9-9278-68D0E5697425
grant_number: '25351'
name: 'A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated
Rapid Growth Inhibition in Arabidopsis Root'
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
record:
- id: '10083'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Functional innovations of PIN auxin transporters mark crucial evolutionary
transitions during rise of flowering plants
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 6
year: '2020'
...
---
_id: '8283'
abstract:
- lang: eng
text: 'Drought and salt stress are the main environmental cues affecting the survival,
development, distribution, and yield of crops worldwide. MYB transcription factors
play a crucial role in plants’ biological processes, but the function of pineapple
MYB genes is still obscure. In this study, one of the pineapple MYB transcription
factors, AcoMYB4, was isolated and characterized. The results showed that AcoMYB4
is localized in the cell nucleus, and its expression is induced by low temperature,
drought, salt stress, and hormonal stimulation, especially by abscisic acid (ABA).
Overexpression of AcoMYB4 in rice and Arabidopsis enhanced plant sensitivity to
osmotic stress; it led to an increase in the number stomata on leaf surfaces and
lower germination rate under salt and drought stress. Furthermore, in AcoMYB4
OE lines, the membrane oxidation index, free proline, and soluble sugar contents
were decreased. In contrast, electrolyte leakage and malondialdehyde (MDA) content
increased significantly due to membrane injury, indicating higher sensitivity
to drought and salinity stresses. Besides the above, both the expression level
and activities of several antioxidant enzymes were decreased, indicating lower
antioxidant activity in AcoMYB4 transgenic plants. Moreover, under osmotic stress,
overexpression of AcoMYB4 inhibited ABA biosynthesis through a decrease in the
transcription of genes responsible for ABA synthesis (ABA1 and ABA2) and ABA signal
transduction factor ABI5. These results suggest that AcoMYB4 negatively regulates
osmotic stress by attenuating cellular ABA biosynthesis and signal transduction
pathways. '
acknowledgement: 'We would like to thank the reviewers for their helpful comments
on the original manuscript. '
article_number: '5272'
article_processing_charge: No
article_type: original
author:
- first_name: Huihuang
full_name: Chen, Huihuang
last_name: Chen
- first_name: Linyi
full_name: Lai, Linyi
last_name: Lai
- first_name: Lanxin
full_name: Li, Lanxin
id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0002-5607-272X
- first_name: Liping
full_name: Liu, Liping
last_name: Liu
- first_name: Bello Hassan
full_name: Jakada, Bello Hassan
last_name: Jakada
- first_name: Youmei
full_name: Huang, Youmei
last_name: Huang
- first_name: Qing
full_name: He, Qing
last_name: He
- first_name: Mengnan
full_name: Chai, Mengnan
last_name: Chai
- first_name: Xiaoping
full_name: Niu, Xiaoping
last_name: Niu
- first_name: Yuan
full_name: Qin, Yuan
last_name: Qin
citation:
ama: Chen H, Lai L, Li L, et al. AcoMYB4, an Ananas comosus L. MYB transcription
factor, functions in osmotic stress through negative regulation of ABA signaling.
International Journal of Molecular Sciences. 2020;21(16). doi:10.3390/ijms21165727
apa: Chen, H., Lai, L., Li, L., Liu, L., Jakada, B. H., Huang, Y., … Qin, Y. (2020).
AcoMYB4, an Ananas comosus L. MYB transcription factor, functions in osmotic stress
through negative regulation of ABA signaling. International Journal of Molecular
Sciences. MDPI. https://doi.org/10.3390/ijms21165727
chicago: Chen, Huihuang, Linyi Lai, Lanxin Li, Liping Liu, Bello Hassan Jakada,
Youmei Huang, Qing He, Mengnan Chai, Xiaoping Niu, and Yuan Qin. “AcoMYB4, an
Ananas Comosus L. MYB Transcription Factor, Functions in Osmotic Stress through
Negative Regulation of ABA Signaling.” International Journal of Molecular Sciences.
MDPI, 2020. https://doi.org/10.3390/ijms21165727.
ieee: H. Chen et al., “AcoMYB4, an Ananas comosus L. MYB transcription factor,
functions in osmotic stress through negative regulation of ABA signaling,” International
Journal of Molecular Sciences, vol. 21, no. 16. MDPI, 2020.
ista: Chen H, Lai L, Li L, Liu L, Jakada BH, Huang Y, He Q, Chai M, Niu X, Qin Y.
2020. AcoMYB4, an Ananas comosus L. MYB transcription factor, functions in osmotic
stress through negative regulation of ABA signaling. International Journal of
Molecular Sciences. 21(16), 5272.
mla: Chen, Huihuang, et al. “AcoMYB4, an Ananas Comosus L. MYB Transcription Factor,
Functions in Osmotic Stress through Negative Regulation of ABA Signaling.” International
Journal of Molecular Sciences, vol. 21, no. 16, 5272, MDPI, 2020, doi:10.3390/ijms21165727.
short: H. Chen, L. Lai, L. Li, L. Liu, B.H. Jakada, Y. Huang, Q. He, M. Chai, X.
Niu, Y. Qin, International Journal of Molecular Sciences 21 (2020).
date_created: 2020-08-24T06:24:03Z
date_published: 2020-08-10T00:00:00Z
date_updated: 2024-03-27T23:30:43Z
day: '10'
ddc:
- '570'
department:
- _id: JiFr
doi: 10.3390/ijms21165727
external_id:
isi:
- '000565090300001'
pmid:
- '32785037'
file:
- access_level: open_access
checksum: 03b039244e6ae80580385fd9f577e2b2
content_type: application/pdf
creator: cziletti
date_created: 2020-08-25T09:53:50Z
date_updated: 2020-08-25T09:53:50Z
file_id: '8292'
file_name: 2020_IntMolecSciences_Chen.pdf
file_size: 5718755
relation: main_file
success: 1
file_date_updated: 2020-08-25T09:53:50Z
has_accepted_license: '1'
intvolume: ' 21'
isi: 1
issue: '16'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: International Journal of Molecular Sciences
publication_identifier:
eissn:
- '14220067'
issn:
- '16616596'
publication_status: published
publisher: MDPI
quality_controlled: '1'
related_material:
record:
- id: '10083'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: AcoMYB4, an Ananas comosus L. MYB transcription factor, functions in osmotic
stress through negative regulation of ABA signaling
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 21
year: '2020'
...
---
_id: '8139'
abstract:
- lang: eng
text: 'Clathrin-mediated endocytosis (CME) is a crucial cellular process implicated
in many aspects of plant growth, development, intra- and inter-cellular signaling,
nutrient uptake and pathogen defense. Despite these significant roles, little
is known about the precise molecular details of how it functions in planta. In
order to facilitate the direct quantitative study of plant CME, here we review
current routinely used methods and present refined, standardized quantitative
imaging protocols which allow the detailed characterization of CME at multiple
scales in plant tissues. These include: (i) an efficient electron microscopy protocol
for the imaging of Arabidopsis CME vesicles in situ, thus providing a method for
the detailed characterization of the ultra-structure of clathrin-coated vesicles;
(ii) a detailed protocol and analysis for quantitative live-cell fluorescence
microscopy to precisely examine the temporal interplay of endocytosis components
during single CME events; (iii) a semi-automated analysis to allow the quantitative
characterization of global internalization of cargos in whole plant tissues; and
(iv) an overview and validation of useful genetic and pharmacological tools to
interrogate the molecular mechanisms and function of CME in intact plant samples.'
acknowledged_ssus:
- _id: EM-Fac
- _id: Bio
acknowledgement: "This paper is dedicated to the memory of Christien Merrifield. He
pioneered quantitative\r\nimaging approaches in mammalian CME and his mentorship
inspired the development of all\r\nthe analysis methods presented here. His joy
in research, pure scientific curiosity and\r\nmicroscopy excellence remain a constant
inspiration. We thank Daniel Van Damme for gifting\r\nus the CLC2-GFP x TPLATE-TagRFP
plants used in this manuscript. We further thank the\r\nScientific Service Units
at IST Austria; specifically, the Electron Microscopy Facility for\r\ntechnical
assistance (in particular Vanessa Zheden) and the BioImaging Facility BioImaging\r\nFacility
for access to equipment. "
article_number: jcs248062
article_processing_charge: No
article_type: original
author:
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: Nataliia
full_name: Gnyliukh, Nataliia
id: 390C1120-F248-11E8-B48F-1D18A9856A87
last_name: Gnyliukh
orcid: 0000-0002-2198-0509
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Madhumitha
full_name: Narasimhan, Madhumitha
id: 44BF24D0-F248-11E8-B48F-1D18A9856A87
last_name: Narasimhan
orcid: 0000-0002-8600-0671
- first_name: G
full_name: Vert, G
last_name: Vert
- first_name: SY
full_name: Bednarek, SY
last_name: Bednarek
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Johnson AJ, Gnyliukh N, Kaufmann W, et al. Experimental toolbox for quantitative
evaluation of clathrin-mediated endocytosis in the plant model Arabidopsis. Journal
of Cell Science. 2020;133(15). doi:10.1242/jcs.248062
apa: Johnson, A. J., Gnyliukh, N., Kaufmann, W., Narasimhan, M., Vert, G., Bednarek,
S., & Friml, J. (2020). Experimental toolbox for quantitative evaluation of
clathrin-mediated endocytosis in the plant model Arabidopsis. Journal of Cell
Science. The Company of Biologists. https://doi.org/10.1242/jcs.248062
chicago: Johnson, Alexander J, Nataliia Gnyliukh, Walter Kaufmann, Madhumitha Narasimhan,
G Vert, SY Bednarek, and Jiří Friml. “Experimental Toolbox for Quantitative Evaluation
of Clathrin-Mediated Endocytosis in the Plant Model Arabidopsis.” Journal of
Cell Science. The Company of Biologists, 2020. https://doi.org/10.1242/jcs.248062.
ieee: A. J. Johnson et al., “Experimental toolbox for quantitative evaluation
of clathrin-mediated endocytosis in the plant model Arabidopsis,” Journal of
Cell Science, vol. 133, no. 15. The Company of Biologists, 2020.
ista: Johnson AJ, Gnyliukh N, Kaufmann W, Narasimhan M, Vert G, Bednarek S, Friml
J. 2020. Experimental toolbox for quantitative evaluation of clathrin-mediated
endocytosis in the plant model Arabidopsis. Journal of Cell Science. 133(15),
jcs248062.
mla: Johnson, Alexander J., et al. “Experimental Toolbox for Quantitative Evaluation
of Clathrin-Mediated Endocytosis in the Plant Model Arabidopsis.” Journal of
Cell Science, vol. 133, no. 15, jcs248062, The Company of Biologists, 2020,
doi:10.1242/jcs.248062.
short: A.J. Johnson, N. Gnyliukh, W. Kaufmann, M. Narasimhan, G. Vert, S. Bednarek,
J. Friml, Journal of Cell Science 133 (2020).
date_created: 2020-07-21T08:58:19Z
date_published: 2020-08-06T00:00:00Z
date_updated: 2023-12-01T13:51:07Z
day: '06'
ddc:
- '575'
department:
- _id: JiFr
- _id: EM-Fac
doi: 10.1242/jcs.248062
ec_funded: 1
external_id:
isi:
- '000561047900021'
pmid:
- '32616560'
file:
- access_level: open_access
checksum: 2d11f79a0b4e0a380fb002b933da331a
content_type: application/pdf
creator: ajohnson
date_created: 2020-11-26T17:12:51Z
date_updated: 2021-08-08T22:30:03Z
embargo: 2021-08-07
file_id: '8815'
file_name: 2020 - Johnson - JSC - plant CME toolbox.pdf
file_size: 15150403
relation: main_file
file_date_updated: 2021-08-08T22:30:03Z
has_accepted_license: '1'
intvolume: ' 133'
isi: 1
issue: '15'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Journal of Cell Science
publication_identifier:
eissn:
- 1477-9137
issn:
- 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
related_material:
record:
- id: '14510'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Experimental toolbox for quantitative evaluation of clathrin-mediated endocytosis
in the plant model Arabidopsis
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 133
year: '2020'
...
---
_id: '9160'
abstract:
- lang: eng
text: Auxin is a key hormonal regulator, that governs plant growth and development
in concert with other hormonal pathways. The unique feature of auxin is its polar,
cell-to-cell transport that leads to the formation of local auxin maxima and gradients,
which coordinate initiation and patterning of plant organs. The molecular machinery
mediating polar auxin transport is one of the important points of interaction
with other hormones. Multiple hormonal pathways converge at the regulation of
auxin transport and form a regulatory network that integrates various developmental
and environmental inputs to steer plant development. In this review, we discuss
recent advances in understanding the mechanisms that underlie regulation of polar
auxin transport by multiple hormonal pathways. Specifically, we focus on the post-translational
mechanisms that contribute to fine-tuning of the abundance and polarity of auxin
transporters at the plasma membrane and thereby enable rapid modification of the
auxin flow to coordinate plant growth and development.
acknowledgement: H.S. is the recipient of a DOC Fellowship of the Austrian Academy
of Sciences at the Institute of Science and Technology, Austria. J.C.M. is the recipient
of an EMBO Long-Term Fellowship (ALTF number 710-2016). We would like to thank Jiri
Friml and Carina Baskett for critical reading of the manuscript and Shutang Tan
and Maciek Adamowski for helpful discussions. No conflict of interest declared.
article_number: '100048'
article_processing_charge: No
article_type: original
author:
- first_name: Hana
full_name: Semeradova, Hana
id: 42FE702E-F248-11E8-B48F-1D18A9856A87
last_name: Semeradova
- first_name: Juan C
full_name: Montesinos López, Juan C
id: 310A8E3E-F248-11E8-B48F-1D18A9856A87
last_name: Montesinos López
orcid: 0000-0001-9179-6099
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
citation:
ama: 'Semerádová H, Montesinos López JC, Benková E. All roads lead to auxin: Post-translational
regulation of auxin transport by multiple hormonal pathways. Plant Communications.
2020;1(3). doi:10.1016/j.xplc.2020.100048'
apa: 'Semerádová, H., Montesinos López, J. C., & Benková, E. (2020). All roads
lead to auxin: Post-translational regulation of auxin transport by multiple hormonal
pathways. Plant Communications. Elsevier. https://doi.org/10.1016/j.xplc.2020.100048'
chicago: 'Semerádová, Hana, Juan C Montesinos López, and Eva Benková. “All Roads
Lead to Auxin: Post-Translational Regulation of Auxin Transport by Multiple Hormonal
Pathways.” Plant Communications. Elsevier, 2020. https://doi.org/10.1016/j.xplc.2020.100048.'
ieee: 'H. Semerádová, J. C. Montesinos López, and E. Benková, “All roads lead to
auxin: Post-translational regulation of auxin transport by multiple hormonal pathways,”
Plant Communications, vol. 1, no. 3. Elsevier, 2020.'
ista: 'Semerádová H, Montesinos López JC, Benková E. 2020. All roads lead to auxin:
Post-translational regulation of auxin transport by multiple hormonal pathways.
Plant Communications. 1(3), 100048.'
mla: 'Semerádová, Hana, et al. “All Roads Lead to Auxin: Post-Translational Regulation
of Auxin Transport by Multiple Hormonal Pathways.” Plant Communications,
vol. 1, no. 3, 100048, Elsevier, 2020, doi:10.1016/j.xplc.2020.100048.'
short: H. Semerádová, J.C. Montesinos López, E. Benková, Plant Communications 1
(2020).
date_created: 2021-02-18T10:18:43Z
date_published: 2020-05-11T00:00:00Z
date_updated: 2024-03-27T23:30:46Z
day: '11'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.1016/j.xplc.2020.100048
external_id:
isi:
- '000654052800010'
pmid:
- '33367243'
file:
- access_level: open_access
checksum: 785b266d82a94b007cf40dbbe7c4847e
content_type: application/pdf
creator: dernst
date_created: 2021-02-18T10:23:59Z
date_updated: 2021-02-18T10:23:59Z
file_id: '9161'
file_name: 2020_PlantComm_Semeradova.pdf
file_size: 840289
relation: main_file
success: 1
file_date_updated: 2021-02-18T10:23:59Z
has_accepted_license: '1'
intvolume: ' 1'
isi: 1
issue: '3'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 261821BC-B435-11E9-9278-68D0E5697425
grant_number: '24746'
name: Molecular mechanisms of the cytokinin regulated endomembrane trafficking to
coordinate plant organogenesis.
- _id: 253E54C8-B435-11E9-9278-68D0E5697425
grant_number: ALTF710-2016
name: Molecular mechanism of auxindriven formative divisions delineating lateral
root organogenesis in plants
publication: Plant Communications
publication_identifier:
issn:
- 2590-3462
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '10135'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'All roads lead to auxin: Post-translational regulation of auxin transport
by multiple hormonal pathways'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 1
year: '2020'
...
---
_id: '10354'
abstract:
- lang: eng
text: "Background\r\nESCRT-III is a membrane remodelling filament with the unique
ability to cut membranes from the inside of the membrane neck. It is essential
for the final stage of cell division, the formation of vesicles, the release of
viruses, and membrane repair. Distinct from other cytoskeletal filaments, ESCRT-III
filaments do not consume energy themselves, but work in conjunction with another
ATP-consuming complex. Despite rapid progress in describing the cell biology of
ESCRT-III, we lack an understanding of the physical mechanisms behind its force
production and membrane remodelling.\r\nResults\r\nHere we present a minimal coarse-grained
model that captures all the experimentally reported cases of ESCRT-III driven
membrane sculpting, including the formation of downward and upward cones and tubules.
This model suggests that a change in the geometry of membrane bound ESCRT-III
filaments—from a flat spiral to a 3D helix—drives membrane deformation. We then
show that such repetitive filament geometry transitions can induce the fission
of cargo-containing vesicles.\r\nConclusions\r\nOur model provides a general physical
mechanism that explains the full range of ESCRT-III-dependent membrane remodelling
and scission events observed in cells. This mechanism for filament force production
is distinct from the mechanisms described for other cytoskeletal elements discovered
so far. The mechanistic principles revealed here suggest new ways of manipulating
ESCRT-III-driven processes in cells and could be used to guide the engineering
of synthetic membrane-sculpting systems."
acknowledgement: We thank Jeremy Carlton, Mike Staddon, Geraint Harker, and the Wellcome
Trust Consortium “Archaeal Origins of Eukaryotic Cell Organisation” for fruitful
conversations. We thank Peter Wirnsberger and Tine Curk for discussions about the
membrane model implementation.
article_number: '82'
article_processing_charge: No
article_type: original
author:
- first_name: Lena
full_name: Harker-Kirschneck, Lena
last_name: Harker-Kirschneck
- first_name: Buzz
full_name: Baum, Buzz
last_name: Baum
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Harker-Kirschneck L, Baum B, Šarić A. Changes in ESCRT-III filament geometry
drive membrane remodelling and fission in silico. BMC Biology. 2019;17(1).
doi:10.1186/s12915-019-0700-2
apa: Harker-Kirschneck, L., Baum, B., & Šarić, A. (2019). Changes in ESCRT-III
filament geometry drive membrane remodelling and fission in silico. BMC Biology.
Springer Nature. https://doi.org/10.1186/s12915-019-0700-2
chicago: Harker-Kirschneck, Lena, Buzz Baum, and Anđela Šarić. “Changes in ESCRT-III
Filament Geometry Drive Membrane Remodelling and Fission in Silico.” BMC Biology.
Springer Nature, 2019. https://doi.org/10.1186/s12915-019-0700-2.
ieee: L. Harker-Kirschneck, B. Baum, and A. Šarić, “Changes in ESCRT-III filament
geometry drive membrane remodelling and fission in silico,” BMC Biology,
vol. 17, no. 1. Springer Nature, 2019.
ista: Harker-Kirschneck L, Baum B, Šarić A. 2019. Changes in ESCRT-III filament
geometry drive membrane remodelling and fission in silico. BMC Biology. 17(1),
82.
mla: Harker-Kirschneck, Lena, et al. “Changes in ESCRT-III Filament Geometry Drive
Membrane Remodelling and Fission in Silico.” BMC Biology, vol. 17, no.
1, 82, Springer Nature, 2019, doi:10.1186/s12915-019-0700-2.
short: L. Harker-Kirschneck, B. Baum, A. Šarić, BMC Biology 17 (2019).
date_created: 2021-11-26T11:25:03Z
date_published: 2019-10-22T00:00:00Z
date_updated: 2021-11-26T11:54:29Z
day: '22'
ddc:
- '570'
doi: 10.1186/s12915-019-0700-2
extern: '1'
external_id:
pmid:
- '31640700'
file:
- access_level: open_access
checksum: 31d8bae55a376d30925f53f7e1a02396
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-26T11:37:54Z
date_updated: 2021-11-26T11:37:54Z
file_id: '10356'
file_name: 2019_BMCBio_Harker_Kirschneck.pdf
file_size: 1648926
relation: main_file
success: 1
file_date_updated: 2021-11-26T11:37:54Z
has_accepted_license: '1'
intvolume: ' 17'
issue: '1'
keyword:
- cell biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/559898
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: BMC Biology
publication_identifier:
issn:
- 1741-7007
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Changes in ESCRT-III filament geometry drive membrane remodelling and fission
in silico
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 17
year: '2019'
...
---
_id: '10355'
abstract:
- lang: eng
text: The molecular machinery of life is largely created via self-organisation of
individual molecules into functional assemblies. Minimal coarse-grained models,
in which a whole macromolecule is represented by a small number of particles,
can be of great value in identifying the main driving forces behind self-organisation
in cell biology. Such models can incorporate data from both molecular and continuum
scales, and their results can be directly compared to experiments. Here we review
the state of the art of models for studying the formation and biological function
of macromolecular assemblies in living organisms. We outline the key ingredients
of each model and their main findings. We illustrate the contribution of this
class of simulations to identifying the physical mechanisms behind life and diseases,
and discuss their future developments.
acknowledgement: We acknowledge funding from EPSRC (A.E.H. and A.Š.), the Academy
of Medical Sciences (J.K. and A.Š.), the Wellcome Trust (J.K. and A.Š.), and the
Royal Society (A.Š.). We thank Shiladitya Banerjee and Nikola Ojkic for critically
reading the manuscript, and Claudia Flandoli for helping us with figures and illustrations.
article_processing_charge: No
article_type: original
author:
- first_name: Anne E
full_name: Hafner, Anne E
last_name: Hafner
- first_name: Johannes
full_name: Krausser, Johannes
last_name: Krausser
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Hafner AE, Krausser J, Šarić A. Minimal coarse-grained models for molecular
self-organisation in biology. Current Opinion in Structural Biology. 2019;58:43-52.
doi:10.1016/j.sbi.2019.05.018
apa: Hafner, A. E., Krausser, J., & Šarić, A. (2019). Minimal coarse-grained
models for molecular self-organisation in biology. Current Opinion in Structural
Biology. Elsevier. https://doi.org/10.1016/j.sbi.2019.05.018
chicago: Hafner, Anne E, Johannes Krausser, and Anđela Šarić. “Minimal Coarse-Grained
Models for Molecular Self-Organisation in Biology.” Current Opinion in Structural
Biology. Elsevier, 2019. https://doi.org/10.1016/j.sbi.2019.05.018.
ieee: A. E. Hafner, J. Krausser, and A. Šarić, “Minimal coarse-grained models for
molecular self-organisation in biology,” Current Opinion in Structural Biology,
vol. 58. Elsevier, pp. 43–52, 2019.
ista: Hafner AE, Krausser J, Šarić A. 2019. Minimal coarse-grained models for molecular
self-organisation in biology. Current Opinion in Structural Biology. 58, 43–52.
mla: Hafner, Anne E., et al. “Minimal Coarse-Grained Models for Molecular Self-Organisation
in Biology.” Current Opinion in Structural Biology, vol. 58, Elsevier,
2019, pp. 43–52, doi:10.1016/j.sbi.2019.05.018.
short: A.E. Hafner, J. Krausser, A. Šarić, Current Opinion in Structural Biology
58 (2019) 43–52.
date_created: 2021-11-26T11:33:21Z
date_published: 2019-06-18T00:00:00Z
date_updated: 2021-11-26T11:54:25Z
day: '18'
doi: 10.1016/j.sbi.2019.05.018
extern: '1'
external_id:
pmid:
- '31226513'
intvolume: ' 58'
keyword:
- molecular biology
- structural biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1906.09349
month: '06'
oa: 1
oa_version: Preprint
page: 43-52
pmid: 1
publication: Current Opinion in Structural Biology
publication_identifier:
issn:
- 0959-440X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Minimal coarse-grained models for molecular self-organisation in biology
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 58
year: '2019'
...
---
_id: '10621'
abstract:
- lang: eng
text: Twisted bilayer graphene has recently emerged as a platform for hosting correlated
phenomena. For twist angles near θ ≈ 1.1°, the low-energy electronic structure
of twisted bilayer graphene features isolated bands with a flat dispersion1,2.
Recent experiments have observed a variety of low-temperature phases that appear
to be driven by electron interactions, including insulating states, superconductivity
and magnetism3,4,5,6. Here we report electrical transport measurements up to room
temperature for twist angles varying between 0.75° and 2°. We find that the resistivity,
ρ, scales linearly with temperature, T, over a wide range of T before falling
again owing to interband activation. The T-linear response is much larger than
observed in monolayer graphene for all measured devices, and in particular increases
by more than three orders of magnitude in the range where the flat band exists.
Our results point to the dominant role of electron–phonon scattering in twisted
bilayer graphene, with possible implications for the origin of the observed superconductivity.
acknowledgement: The authors thank S. Das Sarma and F. Wu for sharing their unpublished
theoretical results, and acknowledge further discussions with L. Balents and T.
Senthil. Work at both Columbia and UCSB was funded by the Army Research Office under
award W911NF-17-1-0323. Sample device design and fabrication was partially supported
by DoE Pro-QM EFRC (DE-SC0019443). A.F.Y. and C.R.D. separately acknowledge the
support of the David and Lucile Packard Foundation. K.W. and T.T. acknowledge support
from the Elemental Strategy Initiative conducted by the MEXT, Japan and the CREST
(JPMJCR15F3), JST. A portion of this work was carried out at the KITP, Santa Barbara,
supported by the National Science Foundation under grant number NSF PHY-1748958.
article_processing_charge: No
article_type: original
author:
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Matthew
full_name: Yankowitz, Matthew
last_name: Yankowitz
- first_name: Shaowen
full_name: Chen, Shaowen
last_name: Chen
- first_name: Yuxuan
full_name: Zhang, Yuxuan
last_name: Zhang
- first_name: K.
full_name: Watanabe, K.
last_name: Watanabe
- first_name: T.
full_name: Taniguchi, T.
last_name: Taniguchi
- first_name: Cory R.
full_name: Dean, Cory R.
last_name: Dean
- first_name: Andrea F.
full_name: Young, Andrea F.
last_name: Young
citation:
ama: Polshyn H, Yankowitz M, Chen S, et al. Large linear-in-temperature resistivity
in twisted bilayer graphene. Nature Physics. 2019;15(10):1011-1016. doi:10.1038/s41567-019-0596-3
apa: Polshyn, H., Yankowitz, M., Chen, S., Zhang, Y., Watanabe, K., Taniguchi, T.,
… Young, A. F. (2019). Large linear-in-temperature resistivity in twisted bilayer
graphene. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-019-0596-3
chicago: Polshyn, Hryhoriy, Matthew Yankowitz, Shaowen Chen, Yuxuan Zhang, K. Watanabe,
T. Taniguchi, Cory R. Dean, and Andrea F. Young. “Large Linear-in-Temperature
Resistivity in Twisted Bilayer Graphene.” Nature Physics. Springer Nature,
2019. https://doi.org/10.1038/s41567-019-0596-3.
ieee: H. Polshyn et al., “Large linear-in-temperature resistivity in twisted
bilayer graphene,” Nature Physics, vol. 15, no. 10. Springer Nature, pp.
1011–1016, 2019.
ista: Polshyn H, Yankowitz M, Chen S, Zhang Y, Watanabe K, Taniguchi T, Dean CR,
Young AF. 2019. Large linear-in-temperature resistivity in twisted bilayer graphene.
Nature Physics. 15(10), 1011–1016.
mla: Polshyn, Hryhoriy, et al. “Large Linear-in-Temperature Resistivity in Twisted
Bilayer Graphene.” Nature Physics, vol. 15, no. 10, Springer Nature, 2019,
pp. 1011–16, doi:10.1038/s41567-019-0596-3.
short: H. Polshyn, M. Yankowitz, S. Chen, Y. Zhang, K. Watanabe, T. Taniguchi, C.R.
Dean, A.F. Young, Nature Physics 15 (2019) 1011–1016.
date_created: 2022-01-13T15:00:58Z
date_published: 2019-08-05T00:00:00Z
date_updated: 2022-01-20T09:33:38Z
day: '05'
doi: 10.1038/s41567-019-0596-3
extern: '1'
external_id:
arxiv:
- '1902.00763'
intvolume: ' 15'
issue: '10'
keyword:
- general physics and astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1902.00763
month: '08'
oa: 1
oa_version: Preprint
page: 1011-1016
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Large linear-in-temperature resistivity in twisted bilayer graphene
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2019'
...
---
_id: '10622'
abstract:
- lang: eng
text: We demonstrate a method for manipulating small ensembles of vortices in multiply
connected superconducting structures. A micron-size magnetic particle attached
to the tip of a silicon cantilever is used to locally apply magnetic flux through
the superconducting structure. By scanning the tip over the surface of the device
and by utilizing the dynamical coupling between the vortices and the cantilever,
a high-resolution spatial map of the different vortex configurations is obtained.
Moving the tip to a particular location in the map stabilizes a distinct multivortex
configuration. Thus, the scanning of the tip over a particular trajectory in space
permits nontrivial operations to be performed, such as braiding of individual
vortices within a larger vortex ensemble—a key capability required by many proposals
for topological quantum computing.
acknowledgement: We are grateful to Nadya Mason, Taylor Hughes, and Alexey Bezryadin
for useful discussions. This work was supported by the DOE Basic Energy Sciences
under DE-SC0012649 and the Department of Physics and the Frederick Seitz Materials
Research Laboratory Central Facilities at the University of Illinois.
article_processing_charge: No
article_type: original
author:
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Tyler
full_name: Naibert, Tyler
last_name: Naibert
- first_name: Raffi
full_name: Budakian, Raffi
last_name: Budakian
citation:
ama: Polshyn H, Naibert T, Budakian R. Manipulating multivortex states in superconducting
structures. Nano Letters. 2019;19(8):5476-5482. doi:10.1021/acs.nanolett.9b01983
apa: Polshyn, H., Naibert, T., & Budakian, R. (2019). Manipulating multivortex
states in superconducting structures. Nano Letters. American Chemical Society.
https://doi.org/10.1021/acs.nanolett.9b01983
chicago: Polshyn, Hryhoriy, Tyler Naibert, and Raffi Budakian. “Manipulating Multivortex
States in Superconducting Structures.” Nano Letters. American Chemical
Society, 2019. https://doi.org/10.1021/acs.nanolett.9b01983.
ieee: H. Polshyn, T. Naibert, and R. Budakian, “Manipulating multivortex states
in superconducting structures,” Nano Letters, vol. 19, no. 8. American
Chemical Society, pp. 5476–5482, 2019.
ista: Polshyn H, Naibert T, Budakian R. 2019. Manipulating multivortex states in
superconducting structures. Nano Letters. 19(8), 5476–5482.
mla: Polshyn, Hryhoriy, et al. “Manipulating Multivortex States in Superconducting
Structures.” Nano Letters, vol. 19, no. 8, American Chemical Society, 2019,
pp. 5476–82, doi:10.1021/acs.nanolett.9b01983.
short: H. Polshyn, T. Naibert, R. Budakian, Nano Letters 19 (2019) 5476–5482.
date_created: 2022-01-13T15:11:14Z
date_published: 2019-06-27T00:00:00Z
date_updated: 2022-01-13T15:41:24Z
day: '27'
doi: 10.1021/acs.nanolett.9b01983
extern: '1'
external_id:
arxiv:
- '1905.06303'
pmid:
- '31246034'
intvolume: ' 19'
issue: '8'
keyword:
- mechanical engineering
- condensed matter physics
- general materials science
- general chemistry
- bioengineering
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1905.06303
month: '06'
oa: 1
oa_version: Preprint
page: 5476-5482
pmid: 1
publication: Nano Letters
publication_identifier:
eissn:
- 1530-6992
issn:
- 1530-6984
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Manipulating multivortex states in superconducting structures
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '2019'
...
---
_id: '10625'
abstract:
- lang: eng
text: The discovery of superconductivity and exotic insulating phases in twisted
bilayer graphene has established this material as a model system of strongly correlated
electrons. To achieve superconductivity, the two layers of graphene need to be
at a very precise angle with respect to each other. Yankowitz et al. now show
that another experimental knob, hydrostatic pressure, can be used to tune the
phase diagram of twisted bilayer graphene (see the Perspective by Feldman). Applying
pressure increased the coupling between the layers, which shifted the superconducting
transition to higher angles and somewhat higher temperatures.
acknowledgement: We thank J. Zhu and H. Zhou for experimental assistance and D. Shahar,
A. Millis, O. Vafek, M. Zaletel, L. Balents, C. Xu, A. Bernevig, L. Fu, M. Koshino,
and P. Moon for helpful discussions.
article_processing_charge: No
article_type: original
author:
- first_name: Matthew
full_name: Yankowitz, Matthew
last_name: Yankowitz
- first_name: Shaowen
full_name: Chen, Shaowen
last_name: Chen
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Yuxuan
full_name: Zhang, Yuxuan
last_name: Zhang
- first_name: K.
full_name: Watanabe, K.
last_name: Watanabe
- first_name: T.
full_name: Taniguchi, T.
last_name: Taniguchi
- first_name: David
full_name: Graf, David
last_name: Graf
- first_name: Andrea F.
full_name: Young, Andrea F.
last_name: Young
- first_name: Cory R.
full_name: Dean, Cory R.
last_name: Dean
citation:
ama: Yankowitz M, Chen S, Polshyn H, et al. Tuning superconductivity in twisted
bilayer graphene. Science. 2019;363(6431):1059-1064. doi:10.1126/science.aav1910
apa: Yankowitz, M., Chen, S., Polshyn, H., Zhang, Y., Watanabe, K., Taniguchi, T.,
… Dean, C. R. (2019). Tuning superconductivity in twisted bilayer graphene. Science.
American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/science.aav1910
chicago: Yankowitz, Matthew, Shaowen Chen, Hryhoriy Polshyn, Yuxuan Zhang, K. Watanabe,
T. Taniguchi, David Graf, Andrea F. Young, and Cory R. Dean. “Tuning Superconductivity
in Twisted Bilayer Graphene.” Science. American Association for the Advancement
of Science (AAAS), 2019. https://doi.org/10.1126/science.aav1910.
ieee: M. Yankowitz et al., “Tuning superconductivity in twisted bilayer graphene,”
Science, vol. 363, no. 6431. American Association for the Advancement of
Science (AAAS), pp. 1059–1064, 2019.
ista: Yankowitz M, Chen S, Polshyn H, Zhang Y, Watanabe K, Taniguchi T, Graf D,
Young AF, Dean CR. 2019. Tuning superconductivity in twisted bilayer graphene.
Science. 363(6431), 1059–1064.
mla: Yankowitz, Matthew, et al. “Tuning Superconductivity in Twisted Bilayer Graphene.”
Science, vol. 363, no. 6431, American Association for the Advancement of
Science (AAAS), 2019, pp. 1059–64, doi:10.1126/science.aav1910.
short: M. Yankowitz, S. Chen, H. Polshyn, Y. Zhang, K. Watanabe, T. Taniguchi, D.
Graf, A.F. Young, C.R. Dean, Science 363 (2019) 1059–1064.
date_created: 2022-01-14T12:14:58Z
date_published: 2019-01-24T00:00:00Z
date_updated: 2022-01-14T13:48:32Z
day: '24'
doi: 10.1126/science.aav1910
extern: '1'
external_id:
arxiv:
- '1808.07865'
pmid:
- '30679385 '
intvolume: ' 363'
issue: '6431'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1808.07865
month: '01'
oa: 1
oa_version: Preprint
page: 1059-1064
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science (AAAS)
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tuning superconductivity in twisted bilayer graphene
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 363
year: '2019'
...
---
_id: '10620'
abstract:
- lang: eng
text: Partially filled Landau levels host competing electronic orders. For example,
electron solids may prevail close to integer filling of the Landau levels before
giving way to fractional quantum Hall liquids at higher carrier density1,2. Here,
we report the observation of an electron solid with non-collinear spin texture
in monolayer graphene, consistent with solidification of skyrmions3—topological
spin textures characterized by quantized electrical charge4,5. We probe the spin
texture of the solids using a modified Corbino geometry that allows ferromagnetic
magnons to be launched and detected6,7. We find that magnon transport is highly
efficient when one Landau level is filled (ν=1), consistent with quantum Hall
ferromagnetic spin polarization. However, even minimal doping immediately quenches
the magnon signal while leaving the vanishing low-temperature charge conductivity
unchanged. Our results can be understood by the formation of a solid of charged
skyrmions near ν=1, whose non-collinear spin texture leads to rapid magnon decay.
Data near fractional fillings show evidence of several fractional skyrmion solids,
suggesting that graphene hosts a highly tunable landscape of coupled spin and
charge orders.
acknowledgement: We acknowledge discussions with B. Halperin, C. Huang, A. Macdonald
and M. Zalatel. Experimental work at UCSB was supported by the Army Research Office
under awards nos. MURI W911NF-16-1-0361 and W911NF-16-1-0482. K.W. and T.T. acknowledge
support from the Elemental Strategy Initiative conducted by MEXT (Japan) and CREST
(JPMJCR15F3), JST. A.F.Y. acknowledges the support of the David and Lucile Packard
Foundation and and Alfred. P. Sloan Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: H.
full_name: Zhou, H.
last_name: Zhou
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: T.
full_name: Taniguchi, T.
last_name: Taniguchi
- first_name: K.
full_name: Watanabe, K.
last_name: Watanabe
- first_name: A. F.
full_name: Young, A. F.
last_name: Young
citation:
ama: Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. Solids of quantum Hall
skyrmions in graphene. Nature Physics. 2019;16(2):154-158. doi:10.1038/s41567-019-0729-8
apa: Zhou, H., Polshyn, H., Taniguchi, T., Watanabe, K., & Young, A. F. (2019).
Solids of quantum Hall skyrmions in graphene. Nature Physics. Springer
Nature. https://doi.org/10.1038/s41567-019-0729-8
chicago: Zhou, H., Hryhoriy Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young.
“Solids of Quantum Hall Skyrmions in Graphene.” Nature Physics. Springer
Nature, 2019. https://doi.org/10.1038/s41567-019-0729-8.
ieee: H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young, “Solids of
quantum Hall skyrmions in graphene,” Nature Physics, vol. 16, no. 2. Springer
Nature, pp. 154–158, 2019.
ista: Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. 2019. Solids of quantum
Hall skyrmions in graphene. Nature Physics. 16(2), 154–158.
mla: Zhou, H., et al. “Solids of Quantum Hall Skyrmions in Graphene.” Nature
Physics, vol. 16, no. 2, Springer Nature, 2019, pp. 154–58, doi:10.1038/s41567-019-0729-8.
short: H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, A.F. Young, Nature Physics
16 (2019) 154–158.
date_created: 2022-01-13T14:45:16Z
date_published: 2019-12-16T00:00:00Z
date_updated: 2022-01-13T15:34:44Z
day: '16'
doi: 10.1038/s41567-019-0729-8
extern: '1'
intvolume: ' 16'
issue: '2'
keyword:
- General Physics and Astronomy
language:
- iso: eng
month: '12'
oa_version: None
page: 154-158
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Solids of quantum Hall skyrmions in graphene
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '2019'
...
---
_id: '10664'
abstract:
- lang: eng
text: "Since the discovery of correlated insulators and superconductivity in magic-angle
twisted bilayer graphene (tBLG) ([1, 2], JCCM April 2018), theorists have been
excitedly pursuing the alluring mix of band topology, symmetry breaking, Mott
insulators and superconductivity at play, as well as the potential relation (if
any) to high-Tc physics. Now a new stream\r\nof experimental work is arriving
which further enriches the story. To briefly recap Episodes 1 and 2 (JCCM April
and November 2018), when two graphene layers are stacked with a small rotational
mismatch θ, the resulting long-wavelength moire pattern leads to a superlattice
potential which reconstructs the low energy band structure. When θ approaches
the “magic-angle” θM ∼ 1 ◦, the band structure features eight nearly-flat bands
which fill when the electron number per moire unit cell, n/n0, lies between −4
< n/n0 < 4. The bands can be counted as 8 = 2 × 2 × 2: for each spin (2×) and
valley (2×) characteristic of monolayergraphene, tBLG has has 2× flat bands which
cross at mini-Dirac points."
article_processing_charge: No
article_type: original
author:
- first_name: Mathew
full_name: Yankowitz, Mathew
last_name: Yankowitz
- first_name: Shaowen
full_name: Chen, Shaowen
last_name: Chen
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: K.
full_name: Watanabe, K.
last_name: Watanabe
- first_name: T.
full_name: Taniguchi, T.
last_name: Taniguchi
- first_name: David
full_name: Graf, David
last_name: Graf
- first_name: Andrea F.
full_name: Young, Andrea F.
last_name: Young
- first_name: Cory R.
full_name: Dean, Cory R.
last_name: Dean
- first_name: Aaron L.
full_name: Sharpe, Aaron L.
last_name: Sharpe
- first_name: E.J.
full_name: Fox, E.J.
last_name: Fox
- first_name: A.W.
full_name: Barnard, A.W.
last_name: Barnard
- first_name: Joe
full_name: Finney, Joe
last_name: Finney
citation:
ama: Yankowitz M, Chen S, Polshyn H, et al. New correlated phenomena in magic-angle
twisted bilayer graphene/s. Journal Club for Condensed Matter Physics.
2019;03. doi:10.36471/jccm_february_2019_03
apa: Yankowitz, M., Chen, S., Polshyn, H., Watanabe, K., Taniguchi, T., Graf, D.,
… Finney, J. (2019). New correlated phenomena in magic-angle twisted bilayer graphene/s.
Journal Club for Condensed Matter Physics. Simons Foundation ; University
of California, Riverside. https://doi.org/10.36471/jccm_february_2019_03
chicago: Yankowitz, Mathew, Shaowen Chen, Hryhoriy Polshyn, K. Watanabe, T. Taniguchi,
David Graf, Andrea F. Young, et al. “New Correlated Phenomena in Magic-Angle Twisted
Bilayer Graphene/S.” Journal Club for Condensed Matter Physics. Simons
Foundation ; University of California, Riverside, 2019. https://doi.org/10.36471/jccm_february_2019_03.
ieee: M. Yankowitz et al., “New correlated phenomena in magic-angle twisted
bilayer graphene/s,” Journal Club for Condensed Matter Physics, vol. 03.
Simons Foundation ; University of California, Riverside, 2019.
ista: Yankowitz M, Chen S, Polshyn H, Watanabe K, Taniguchi T, Graf D, Young AF,
Dean CR, Sharpe AL, Fox EJ, Barnard AW, Finney J. 2019. New correlated phenomena
in magic-angle twisted bilayer graphene/s. Journal Club for Condensed Matter Physics.
03.
mla: Yankowitz, Mathew, et al. “New Correlated Phenomena in Magic-Angle Twisted
Bilayer Graphene/S.” Journal Club for Condensed Matter Physics, vol. 03,
Simons Foundation ; University of California, Riverside, 2019, doi:10.36471/jccm_february_2019_03.
short: M. Yankowitz, S. Chen, H. Polshyn, K. Watanabe, T. Taniguchi, D. Graf, A.F.
Young, C.R. Dean, A.L. Sharpe, E.J. Fox, A.W. Barnard, J. Finney, Journal Club
for Condensed Matter Physics 03 (2019).
date_created: 2022-01-25T15:09:58Z
date_published: 2019-02-28T00:00:00Z
date_updated: 2022-01-25T15:56:39Z
day: '28'
doi: 10.36471/jccm_february_2019_03
intvolume: ' 3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.condmatjclub.org/?p=3541
month: '02'
oa: 1
oa_version: Published Version
publication: Journal Club for Condensed Matter Physics
publication_status: published
publisher: Simons Foundation ; University of California, Riverside
quality_controlled: '1'
status: public
title: New correlated phenomena in magic-angle twisted bilayer graphene/s
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: '03'
year: '2019'
...
---
_id: '10619'
abstract:
- lang: eng
text: The quantum anomalous Hall (QAH) effect combines topology and magnetism to
produce precisely quantized Hall resistance at zero magnetic field. We report
the observation of a QAH effect in twisted bilayer graphene aligned to hexagonal
boron nitride. The effect is driven by intrinsic strong interactions, which polarize
the electrons into a single spin- and valley-resolved moiré miniband with Chern
number C = 1. In contrast to magnetically doped systems, the measured transport
energy gap is larger than the Curie temperature for magnetic ordering, and quantization
to within 0.1% of the von Klitzing constant persists to temperatures of several
kelvin at zero magnetic field. Electrical currents as small as 1 nanoampere controllably
switch the magnetic order between states of opposite polarization, forming an
electrically rewritable magnetic memory.
acknowledgement: The authors acknowledge discussions with A. Macdonald, Y. Saito,
and M. Zaletel.
article_processing_charge: No
article_type: original
author:
- first_name: M.
full_name: Serlin, M.
last_name: Serlin
- first_name: C. L.
full_name: Tschirhart, C. L.
last_name: Tschirhart
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Y.
full_name: Zhang, Y.
last_name: Zhang
- first_name: J.
full_name: Zhu, J.
last_name: Zhu
- first_name: K.
full_name: Watanabe, K.
last_name: Watanabe
- first_name: T.
full_name: Taniguchi, T.
last_name: Taniguchi
- first_name: L.
full_name: Balents, L.
last_name: Balents
- first_name: A. F.
full_name: Young, A. F.
last_name: Young
citation:
ama: Serlin M, Tschirhart CL, Polshyn H, et al. Intrinsic quantized anomalous Hall
effect in a moiré heterostructure. Science. 2019;367(6480):900-903. doi:10.1126/science.aay5533
apa: Serlin, M., Tschirhart, C. L., Polshyn, H., Zhang, Y., Zhu, J., Watanabe, K.,
… Young, A. F. (2019). Intrinsic quantized anomalous Hall effect in a moiré heterostructure.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aay5533
chicago: Serlin, M., C. L. Tschirhart, Hryhoriy Polshyn, Y. Zhang, J. Zhu, K. Watanabe,
T. Taniguchi, L. Balents, and A. F. Young. “Intrinsic Quantized Anomalous Hall
Effect in a Moiré Heterostructure.” Science. American Association for the
Advancement of Science, 2019. https://doi.org/10.1126/science.aay5533.
ieee: M. Serlin et al., “Intrinsic quantized anomalous Hall effect in a moiré
heterostructure,” Science, vol. 367, no. 6480. American Association for
the Advancement of Science, pp. 900–903, 2019.
ista: Serlin M, Tschirhart CL, Polshyn H, Zhang Y, Zhu J, Watanabe K, Taniguchi
T, Balents L, Young AF. 2019. Intrinsic quantized anomalous Hall effect in a moiré
heterostructure. Science. 367(6480), 900–903.
mla: Serlin, M., et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure.”
Science, vol. 367, no. 6480, American Association for the Advancement of
Science, 2019, pp. 900–03, doi:10.1126/science.aay5533.
short: M. Serlin, C.L. Tschirhart, H. Polshyn, Y. Zhang, J. Zhu, K. Watanabe, T.
Taniguchi, L. Balents, A.F. Young, Science 367 (2019) 900–903.
date_created: 2022-01-13T14:21:32Z
date_published: 2019-12-19T00:00:00Z
date_updated: 2023-02-21T16:00:09Z
day: '19'
doi: 10.1126/science.aay5533
extern: '1'
external_id:
arxiv:
- '1907.00261'
pmid:
- '31857492'
intvolume: ' 367'
issue: '6480'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1907.00261
month: '12'
oa: 1
oa_version: Preprint
page: 900-903
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
record:
- id: '10697'
relation: other
status: public
- id: '10698'
relation: other
status: public
- id: '10699'
relation: other
status: public
scopus_import: '1'
status: public
title: Intrinsic quantized anomalous Hall effect in a moiré heterostructure
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 367
year: '2019'
...
---
_id: '10724'
abstract:
- lang: eng
text: Twisted bilayer graphene (tBLG) near the flat band condition is a versatile
new platform for the study of correlated physics in 2D. Resistive states have
been observed at several commensurate fillings of the flat miniband, along with
superconducting states near half filling. To better understand the electronic
structure of this system, we study electronic transport of graphite gated superconducting
tBLG devices in the normal regime. At high magnetic fields, we observe full lifting
of the spin and valley degeneracy. The transitions in the splitting of this four-fold
degeneracy as a function of carrier density indicate Landau level (LL) crossings,
which tilted field measurements show occur between LLs with different valley polarization.
Similar LL structure measured in two devices, one with twist angle θ=1.08° at
ambient pressure and one at θ=1.27° and 1.33GPa, suggests that the dimensionless
combination of twist angle and interlayer coupling controls the relevant details
of the band structure. In addition, we find that the temperature dependence of
the resistance at B=0 shows linear growth at several hundred Ohm/K in a broad
range of temperatures. We discuss the implications for modeling the scattering
processes in this system.
alternative_title:
- Bulletin of the American Physical Society
article_number: V14.00008
article_processing_charge: No
author:
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Yuxuan
full_name: Zhang, Yuxuan
last_name: Zhang
- first_name: Matthew
full_name: Yankowitz, Matthew
last_name: Yankowitz
- first_name: Shaowen
full_name: Chen, Shaowen
last_name: Chen
- first_name: Takashi
full_name: Taniguchi, Takashi
last_name: Taniguchi
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: David E.
full_name: Graf, David E.
last_name: Graf
- first_name: Cory R.
full_name: Dean, Cory R.
last_name: Dean
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
citation:
ama: 'Polshyn H, Zhang Y, Yankowitz M, et al. Normal state transport in superconducting
twisted bilayer graphene. In: APS March Meeting 2019. Vol 64. American
Physical Society; 2019.'
apa: 'Polshyn, H., Zhang, Y., Yankowitz, M., Chen, S., Taniguchi, T., Watanabe,
K., … Young, A. (2019). Normal state transport in superconducting twisted bilayer
graphene. In APS March Meeting 2019 (Vol. 64). Boston, MA, United States:
American Physical Society.'
chicago: Polshyn, Hryhoriy, Yuxuan Zhang, Matthew Yankowitz, Shaowen Chen, Takashi
Taniguchi, Kenji Watanabe, David E. Graf, Cory R. Dean, and Andrea Young. “Normal
State Transport in Superconducting Twisted Bilayer Graphene.” In APS March
Meeting 2019, Vol. 64. American Physical Society, 2019.
ieee: H. Polshyn et al., “Normal state transport in superconducting twisted
bilayer graphene,” in APS March Meeting 2019, Boston, MA, United States,
2019, vol. 64, no. 2.
ista: 'Polshyn H, Zhang Y, Yankowitz M, Chen S, Taniguchi T, Watanabe K, Graf DE,
Dean CR, Young A. 2019. Normal state transport in superconducting twisted bilayer
graphene. APS March Meeting 2019. APS: American Physical Society, Bulletin of
the American Physical Society, vol. 64, V14.00008.'
mla: Polshyn, Hryhoriy, et al. “Normal State Transport in Superconducting Twisted
Bilayer Graphene.” APS March Meeting 2019, vol. 64, no. 2, V14.00008, American
Physical Society, 2019.
short: H. Polshyn, Y. Zhang, M. Yankowitz, S. Chen, T. Taniguchi, K. Watanabe, D.E.
Graf, C.R. Dean, A. Young, in:, APS March Meeting 2019, American Physical Society,
2019.
conference:
end_date: 2019-03-08
location: Boston, MA, United States
name: 'APS: American Physical Society'
start_date: 2019-03-04
date_created: 2022-02-04T12:25:04Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2022-02-08T10:23:13Z
day: '01'
extern: '1'
intvolume: ' 64'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR19/Session/V14.8
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2019
publication_identifier:
issn:
- 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Normal state transport in superconducting twisted bilayer graphene
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 64
year: '2019'
...
---
_id: '10722'
abstract:
- lang: eng
text: Bilayer graphene, rotationally faulted to ~1.1 degree misalignment, has recently
been shown to host superconducting and resistive states associated with the formation
of a flat electronic band. While numerous theories exist for the origins of both
states, direct validation of these theories remains an outstanding experimental
problem. Here, we focus on the resistive states occurring at commensurate filling
(1/2, 1/4, and 3/4) of the two lowest superlattice bands. We test theoretical
proposals that these states arise due to broken spin—and/or valley—symmetry by
performing direct magnetic imaging with nanoscale SQUID-on-tip microscopy. This
technique provides single-spin resolved magnetometry on sub-100nm length scales.
I will present imaging data from our 4.2K nSOT microscope on graphite-gated twisted
bilayers near the flat band condition and discuss the implications for the physics
of the commensurate resistive states.
alternative_title:
- Bulletin of the American Physical Society
article_number: L14.00006
article_processing_charge: No
author:
- first_name: Marec
full_name: Serlin, Marec
last_name: Serlin
- first_name: Charles
full_name: Tschirhart, Charles
last_name: Tschirhart
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Jiacheng
full_name: Zhu, Jiacheng
last_name: Zhu
- first_name: Martin E.
full_name: Huber, Martin E.
last_name: Huber
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
citation:
ama: 'Serlin M, Tschirhart C, Polshyn H, Zhu J, Huber ME, Young A. Direct Imaging
of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip
microscopy. In: APS March Meeting 2019. Vol 64. American Physical Society;
2019.'
apa: 'Serlin, M., Tschirhart, C., Polshyn, H., Zhu, J., Huber, M. E., & Young,
A. (2019). Direct Imaging of magnetic structure in twisted bilayer graphene with
scanning nanoSQUID-On-Tip microscopy. In APS March Meeting 2019 (Vol. 64).
Boston, MA, United States: American Physical Society.'
chicago: Serlin, Marec, Charles Tschirhart, Hryhoriy Polshyn, Jiacheng Zhu, Martin
E. Huber, and Andrea Young. “Direct Imaging of Magnetic Structure in Twisted Bilayer
Graphene with Scanning NanoSQUID-On-Tip Microscopy.” In APS March Meeting 2019,
Vol. 64. American Physical Society, 2019.
ieee: M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, M. E. Huber, and A. Young, “Direct
Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip
microscopy,” in APS March Meeting 2019, Boston, MA, United States, 2019,
vol. 64, no. 2.
ista: 'Serlin M, Tschirhart C, Polshyn H, Zhu J, Huber ME, Young A. 2019. Direct
Imaging of magnetic structure in twisted bilayer graphene with scanning nanoSQUID-On-Tip
microscopy. APS March Meeting 2019. APS: American Physical Society, Bulletin of
the American Physical Society, vol. 64, L14.00006.'
mla: Serlin, Marec, et al. “Direct Imaging of Magnetic Structure in Twisted Bilayer
Graphene with Scanning NanoSQUID-On-Tip Microscopy.” APS March Meeting 2019,
vol. 64, no. 2, L14.00006, American Physical Society, 2019.
short: M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, M.E. Huber, A. Young, in:,
APS March Meeting 2019, American Physical Society, 2019.
conference:
end_date: 2019-03-08
location: Boston, MA, United States
name: 'APS: American Physical Society'
start_date: 2019-03-04
date_created: 2022-02-04T11:54:21Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2022-02-08T10:25:30Z
day: '01'
extern: '1'
intvolume: ' 64'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR19/Session/L14.6
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2019
publication_identifier:
issn:
- 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Direct Imaging of magnetic structure in twisted bilayer graphene with scanning
nanoSQUID-On-Tip microscopy
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 64
year: '2019'
...
---
_id: '10725'
abstract:
- lang: eng
text: Bilayer graphene with ~ 1.1 degrees twist mismatch between the layers hosts
a low energy flat band in which the Coulomb interaction is large relative to the
bandwidth, promoting correlated insulating states at half band filling, and superconducting
(SC) phases with dome-like structure neighboring correlated insulating states.
Here we show measurements of a dual-graphite-gated twisted bilayer graphene device,
which minimizes charge inhomogeneity. We observe new correlated phases, including
for the first time a SC pocket near half-filling of the electron-doped band and
resistive states at quarter-filling of both bands that emerge in a magnetic field.
Changing the layer polarization with vertical electric field reveals an unexpected
competition between SC and correlated insulator phases, which we interpret to
result from differences in disorder of each graphene layer and underscores the
spatial inhomogeneity like twist angle as a significant source of disorder in
these devices [1].
alternative_title:
- Bulletin of the American Physical Society
article_number: R14.00004
article_processing_charge: No
author:
- first_name: Shaowen
full_name: Chen, Shaowen
last_name: Chen
- first_name: Matthew
full_name: Yankowitz, Matthew
last_name: Yankowitz
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: Takashi
full_name: Taniguchi, Takashi
last_name: Taniguchi
- first_name: David E.
full_name: Graf, David E.
last_name: Graf
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
- first_name: Cory R.
full_name: Dean, Cory R.
last_name: Dean
citation:
ama: 'Chen S, Yankowitz M, Polshyn H, et al. Correlated insulating and superconducting
phases in twisted bilayer graphene. In: APS March Meeting 2019. Vol 64.
American Physical Society; 2019.'
apa: 'Chen, S., Yankowitz, M., Polshyn, H., Watanabe, K., Taniguchi, T., Graf, D.
E., … Dean, C. R. (2019). Correlated insulating and superconducting phases in
twisted bilayer graphene. In APS March Meeting 2019 (Vol. 64). Boston,
MA, United States: American Physical Society.'
chicago: Chen, Shaowen, Matthew Yankowitz, Hryhoriy Polshyn, Kenji Watanabe, Takashi
Taniguchi, David E. Graf, Andrea Young, and Cory R. Dean. “Correlated Insulating
and Superconducting Phases in Twisted Bilayer Graphene.” In APS March Meeting
2019, Vol. 64. American Physical Society, 2019.
ieee: S. Chen et al., “Correlated insulating and superconducting phases in
twisted bilayer graphene,” in APS March Meeting 2019, Boston, MA, United
States, 2019, vol. 64, no. 2.
ista: 'Chen S, Yankowitz M, Polshyn H, Watanabe K, Taniguchi T, Graf DE, Young A,
Dean CR. 2019. Correlated insulating and superconducting phases in twisted bilayer
graphene. APS March Meeting 2019. APS: American Physical Society, Bulletin of
the American Physical Society, vol. 64, R14.00004.'
mla: Chen, Shaowen, et al. “Correlated Insulating and Superconducting Phases in
Twisted Bilayer Graphene.” APS March Meeting 2019, vol. 64, no. 2, R14.00004,
American Physical Society, 2019.
short: S. Chen, M. Yankowitz, H. Polshyn, K. Watanabe, T. Taniguchi, D.E. Graf,
A. Young, C.R. Dean, in:, APS March Meeting 2019, American Physical Society, 2019.
conference:
end_date: 2019-03-08
location: Boston, MA, United States
name: 'APS: American Physical Society'
start_date: 2019-03-04
date_created: 2022-02-04T13:48:04Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2022-02-08T10:24:13Z
day: '01'
extern: '1'
intvolume: ' 64'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR19/Session/R14.4
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2019
publication_identifier:
issn:
- 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
link:
- relation: used_in_publication
url: https://arxiv.org/abs/1808.07865
status: public
title: Correlated insulating and superconducting phases in twisted bilayer graphene
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 64
year: '2019'
...
---
_id: '10723'
abstract:
- lang: eng
text: In monolayer graphene, the interplay of electronic correlations with the internal
spin- and valley- degrees of freedom leads to a complex phase diagram of isospin
symmetry breaking at high magnetic fields. Recently, Wei et al. (Science (2018))
demonstrated that spin waves can be electrically generated and detected in graphene
heterojunctions, allowing direct experiment access to the spin degree of freedom.
Here, we apply this technique to high quality graphite-gated graphene devices
showing robust fractional quantum Hall phases and isospin phase transitions. We
use an edgeless Corbino geometry to eliminate the contributions of edge states
to the spin-wave mediated nonlocal voltage, allowing unambiguous identification
of spin wave transport signatures. Our data reveal two phases within the ν = 1
plateau. For exactly ν=1, charge is localized but spin waves propagate freely
while small carrier doping completely quenches the low-energy spin-wave transport,
even as those charges remain localized. We identify this new phase as a spin textured
electron solid. We also find that spin-wave transport is modulated by phase transitions
in the valley order that preserve spin polarization, suggesting that this technique
is sensitive to both spin and valley order.
article_number: P01.00004
article_processing_charge: No
author:
- first_name: Haoxin
full_name: Zhou, Haoxin
last_name: Zhou
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Takashi
full_name: Tanaguchi, Takashi
last_name: Tanaguchi
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
citation:
ama: 'Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. Spin wave transport through
electron solids and fractional quantum Hall liquids in graphene. In: APS March
Meeting 2019. Vol 64. American Physical Society; 2019.'
apa: 'Zhou, H., Polshyn, H., Tanaguchi, T., Watanabe, K., & Young, A. (2019).
Spin wave transport through electron solids and fractional quantum Hall liquids
in graphene. In APS March Meeting 2019 (Vol. 64). Boston, MA, United States:
American Physical Society.'
chicago: Zhou, Haoxin, Hryhoriy Polshyn, Takashi Tanaguchi, Kenji Watanabe, and
Andrea Young. “Spin Wave Transport through Electron Solids and Fractional Quantum
Hall Liquids in Graphene.” In APS March Meeting 2019, Vol. 64. American
Physical Society, 2019.
ieee: H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, and A. Young, “Spin wave transport
through electron solids and fractional quantum Hall liquids in graphene,” in APS
March Meeting 2019, Boston, MA, United States, 2019, vol. 64, no. 2.
ista: 'Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. 2019. Spin wave transport
through electron solids and fractional quantum Hall liquids in graphene. APS March
Meeting 2019. APS: American Physical Society vol. 64, P01.00004.'
mla: Zhou, Haoxin, et al. “Spin Wave Transport through Electron Solids and Fractional
Quantum Hall Liquids in Graphene.” APS March Meeting 2019, vol. 64, no.
2, P01.00004, American Physical Society, 2019.
short: H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, A. Young, in:, APS March
Meeting 2019, American Physical Society, 2019.
conference:
end_date: 2019-03-08
location: Boston, MA, United States
name: 'APS: American Physical Society'
start_date: 2019-03-04
date_created: 2022-02-04T12:14:02Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2022-02-04T13:59:47Z
day: '01'
extern: '1'
intvolume: ' 64'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR19/Session/P01.4
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2019
publication_identifier:
issn:
- 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Spin wave transport through electron solids and fractional quantum Hall liquids
in graphene
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 64
year: '2019'
...
---
_id: '10877'
abstract:
- lang: eng
text: 'This report presents the results of a friendly competition for formal verification
of continuous and hybrid systems with piecewise constant dynamics. The friendly
competition took place as part of the workshop Applied Verification for Continuous
and Hybrid Systems (ARCH) in 2019. In this third edition, six tools have been
applied to solve five different benchmark problems in the category for piecewise
constant dynamics: BACH, Lyse, Hy- COMP, PHAVer/SX, PHAVerLite, and VeriSiMPL.
Compared to last year, a new tool has participated (HyCOMP) and PHAVerLite has
replaced PHAVer-lite. The result is a snap- shot of the current landscape of tools
and the types of benchmarks they are particularly suited for. Due to the diversity
of problems, we are not ranking tools, yet the presented results probably provide
the most complete assessment of tools for the safety verification of continuous
and hybrid systems with piecewise constant dynamics up to this date.'
acknowledgement: "The authors gratefully acknowledge \fnancial support by the European
Commission project\r\nUnCoVerCPS under grant number 643921. Lei Bu is supported
by the National Natural Science\r\nFoundation of China (No.61572249)."
alternative_title:
- EPiC Series in Computing
article_processing_charge: No
author:
- first_name: Goran
full_name: Frehse, Goran
last_name: Frehse
- first_name: Alessandro
full_name: Abate, Alessandro
last_name: Abate
- first_name: Dieky
full_name: Adzkiya, Dieky
last_name: Adzkiya
- first_name: Anna
full_name: Becchi, Anna
last_name: Becchi
- first_name: Lei
full_name: Bu, Lei
last_name: Bu
- first_name: Alessandro
full_name: Cimatti, Alessandro
last_name: Cimatti
- first_name: Mirco
full_name: Giacobbe, Mirco
id: 3444EA5E-F248-11E8-B48F-1D18A9856A87
last_name: Giacobbe
orcid: 0000-0001-8180-0904
- first_name: Alberto
full_name: Griggio, Alberto
last_name: Griggio
- first_name: Sergio
full_name: Mover, Sergio
last_name: Mover
- first_name: Muhammad Syifa'ul
full_name: Mufid, Muhammad Syifa'ul
last_name: Mufid
- first_name: Idriss
full_name: Riouak, Idriss
last_name: Riouak
- first_name: Stefano
full_name: Tonetta, Stefano
last_name: Tonetta
- first_name: Enea
full_name: Zaffanella, Enea
last_name: Zaffanella
citation:
ama: 'Frehse G, Abate A, Adzkiya D, et al. ARCH-COMP19 Category Report: Hybrid systems
with piecewise constant dynamics. In: Frehse G, Althoff M, eds. ARCH19. 6th
International Workshop on Applied Verification of Continuous and Hybrid Systems.
Vol 61. EasyChair; 2019:1-13. doi:10.29007/rjwn'
apa: 'Frehse, G., Abate, A., Adzkiya, D., Becchi, A., Bu, L., Cimatti, A., … Zaffanella,
E. (2019). ARCH-COMP19 Category Report: Hybrid systems with piecewise constant
dynamics. In G. Frehse & M. Althoff (Eds.), ARCH19. 6th International Workshop
on Applied Verification of Continuous and Hybrid Systems (Vol. 61, pp. 1–13).
Montreal, Canada: EasyChair. https://doi.org/10.29007/rjwn'
chicago: 'Frehse, Goran, Alessandro Abate, Dieky Adzkiya, Anna Becchi, Lei Bu, Alessandro
Cimatti, Mirco Giacobbe, et al. “ARCH-COMP19 Category Report: Hybrid Systems with
Piecewise Constant Dynamics.” In ARCH19. 6th International Workshop on Applied
Verification of Continuous and Hybrid Systems, edited by Goran Frehse and
Matthias Althoff, 61:1–13. EasyChair, 2019. https://doi.org/10.29007/rjwn.'
ieee: 'G. Frehse et al., “ARCH-COMP19 Category Report: Hybrid systems with
piecewise constant dynamics,” in ARCH19. 6th International Workshop on Applied
Verification of Continuous and Hybrid Systems, Montreal, Canada, 2019, vol.
61, pp. 1–13.'
ista: 'Frehse G, Abate A, Adzkiya D, Becchi A, Bu L, Cimatti A, Giacobbe M, Griggio
A, Mover S, Mufid MS, Riouak I, Tonetta S, Zaffanella E. 2019. ARCH-COMP19 Category
Report: Hybrid systems with piecewise constant dynamics. ARCH19. 6th International
Workshop on Applied Verification of Continuous and Hybrid Systems. ARCH: International
Workshop on Applied Verification on Continuous and Hybrid Systems, EPiC Series
in Computing, vol. 61, 1–13.'
mla: 'Frehse, Goran, et al. “ARCH-COMP19 Category Report: Hybrid Systems with Piecewise
Constant Dynamics.” ARCH19. 6th International Workshop on Applied Verification
of Continuous and Hybrid Systems, edited by Goran Frehse and Matthias Althoff,
vol. 61, EasyChair, 2019, pp. 1–13, doi:10.29007/rjwn.'
short: G. Frehse, A. Abate, D. Adzkiya, A. Becchi, L. Bu, A. Cimatti, M. Giacobbe,
A. Griggio, S. Mover, M.S. Mufid, I. Riouak, S. Tonetta, E. Zaffanella, in:, G.
Frehse, M. Althoff (Eds.), ARCH19. 6th International Workshop on Applied Verification
of Continuous and Hybrid Systems, EasyChair, 2019, pp. 1–13.
conference:
end_date: 2019-04-15
location: Montreal, Canada
name: 'ARCH: International Workshop on Applied Verification on Continuous and Hybrid
Systems'
start_date: 2019-04-15
date_created: 2022-03-18T12:29:23Z
date_published: 2019-05-25T00:00:00Z
date_updated: 2022-05-17T07:09:47Z
day: '25'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.29007/rjwn
editor:
- first_name: Goran
full_name: Frehse, Goran
last_name: Frehse
- first_name: Matthias
full_name: Althoff, Matthias
last_name: Althoff
file:
- access_level: open_access
checksum: 4b92e333db7b4e2349501a804dfede69
content_type: application/pdf
creator: dernst
date_created: 2022-05-17T06:55:49Z
date_updated: 2022-05-17T06:55:49Z
file_id: '11391'
file_name: 2019_EPiCs_Frehse.pdf
file_size: 346415
relation: main_file
success: 1
file_date_updated: 2022-05-17T06:55:49Z
has_accepted_license: '1'
intvolume: ' 61'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 1-13
publication: ARCH19. 6th International Workshop on Applied Verification of Continuous
and Hybrid Systems
publication_identifier:
issn:
- 2398-7340
publication_status: published
publisher: EasyChair
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'ARCH-COMP19 Category Report: Hybrid systems with piecewise constant dynamics'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2019'
...
---
_id: '11061'
abstract:
- lang: eng
text: Many adult tissues contain postmitotic cells as old as the host organism.
The only organelle that does not turn over in these cells is the nucleus, and
its maintenance represents a formidable challenge, as it harbors regulatory proteins
that persist throughout adulthood. Here we developed strategies to visualize two
classes of such long-lived proteins, histones and nucleoporins, to understand
the function of protein longevity in nuclear maintenance. Genome-wide mapping
of histones revealed specific enrichment of long-lived variants at silent gene
loci. Interestingly, nuclear pores are maintained by piecemeal replacement of
subunits, resulting in mosaic complexes composed of polypeptides with vastly different
ages. In contrast, nondividing quiescent cells remove old nuclear pores in an
ESCRT-dependent manner. Our findings reveal distinct molecular strategies of nuclear
maintenance, linking lifelong protein persistence to gene regulation and nuclear
integrity.
article_processing_charge: No
article_type: original
author:
- first_name: Brandon H.
full_name: Toyama, Brandon H.
last_name: Toyama
- first_name: Rafael
full_name: Arrojo e Drigo, Rafael
last_name: Arrojo e Drigo
- first_name: Varda
full_name: Lev-Ram, Varda
last_name: Lev-Ram
- first_name: Ranjan
full_name: Ramachandra, Ranjan
last_name: Ramachandra
- first_name: Thomas J.
full_name: Deerinck, Thomas J.
last_name: Deerinck
- first_name: Claude
full_name: Lechene, Claude
last_name: Lechene
- first_name: Mark H.
full_name: Ellisman, Mark H.
last_name: Ellisman
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Toyama BH, Arrojo e Drigo R, Lev-Ram V, et al. Visualization of long-lived
proteins reveals age mosaicism within nuclei of postmitotic cells. Journal
of Cell Biology. 2019;218(2):433-444. doi:10.1083/jcb.201809123
apa: Toyama, B. H., Arrojo e Drigo, R., Lev-Ram, V., Ramachandra, R., Deerinck,
T. J., Lechene, C., … Hetzer, M. (2019). Visualization of long-lived proteins
reveals age mosaicism within nuclei of postmitotic cells. Journal of Cell Biology.
Rockefeller University Press. https://doi.org/10.1083/jcb.201809123
chicago: Toyama, Brandon H., Rafael Arrojo e Drigo, Varda Lev-Ram, Ranjan Ramachandra,
Thomas J. Deerinck, Claude Lechene, Mark H. Ellisman, and Martin Hetzer. “Visualization
of Long-Lived Proteins Reveals Age Mosaicism within Nuclei of Postmitotic Cells.”
Journal of Cell Biology. Rockefeller University Press, 2019. https://doi.org/10.1083/jcb.201809123.
ieee: B. H. Toyama et al., “Visualization of long-lived proteins reveals
age mosaicism within nuclei of postmitotic cells,” Journal of Cell Biology,
vol. 218, no. 2. Rockefeller University Press, pp. 433–444, 2019.
ista: Toyama BH, Arrojo e Drigo R, Lev-Ram V, Ramachandra R, Deerinck TJ, Lechene
C, Ellisman MH, Hetzer M. 2019. Visualization of long-lived proteins reveals age
mosaicism within nuclei of postmitotic cells. Journal of Cell Biology. 218(2),
433–444.
mla: Toyama, Brandon H., et al. “Visualization of Long-Lived Proteins Reveals Age
Mosaicism within Nuclei of Postmitotic Cells.” Journal of Cell Biology,
vol. 218, no. 2, Rockefeller University Press, 2019, pp. 433–44, doi:10.1083/jcb.201809123.
short: B.H. Toyama, R. Arrojo e Drigo, V. Lev-Ram, R. Ramachandra, T.J. Deerinck,
C. Lechene, M.H. Ellisman, M. Hetzer, Journal of Cell Biology 218 (2019) 433–444.
date_created: 2022-04-07T07:45:11Z
date_published: 2019-02-04T00:00:00Z
date_updated: 2022-07-18T08:31:52Z
day: '04'
ddc:
- '570'
doi: 10.1083/jcb.201809123
extern: '1'
external_id:
pmid:
- '30552100'
file:
- access_level: open_access
checksum: 7964ebbf833b0b35f9fba840eea9531d
content_type: application/pdf
creator: dernst
date_created: 2022-04-08T08:26:32Z
date_updated: 2022-04-08T08:26:32Z
file_id: '11139'
file_name: 2019_JCB_Toyama.pdf
file_size: 2503838
relation: main_file
success: 1
file_date_updated: 2022-04-08T08:26:32Z
has_accepted_license: '1'
intvolume: ' 218'
issue: '2'
keyword:
- Cell Biology
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 433-444
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Visualization of long-lived proteins reveals age mosaicism within nuclei of
postmitotic cells
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 218
year: '2019'
...
---
_id: '11062'
abstract:
- lang: eng
text: Most neurons are not replaced during an animal’s lifetime. This nondividing
state is characterized by extreme longevity and age-dependent decline of key regulatory
proteins. To study the lifespans of cells and proteins in adult tissues, we combined
isotope labeling of mice with a hybrid imaging method (MIMS-EM). Using 15N mapping,
we show that liver and pancreas are composed of cells with vastly different ages,
many as old as the animal. Strikingly, we also found that a subset of fibroblasts
and endothelial cells, both known for their replicative potential, are characterized
by the absence of cell division during adulthood. In addition, we show that the
primary cilia of beta cells and neurons contains different structural regions
with vastly different lifespans. Based on these results, we propose that age mosaicism
across multiple scales is a fundamental principle of adult tissue, cell, and protein
complex organization.
article_processing_charge: No
article_type: original
author:
- first_name: Rafael
full_name: Arrojo e Drigo, Rafael
last_name: Arrojo e Drigo
- first_name: Varda
full_name: Lev-Ram, Varda
last_name: Lev-Ram
- first_name: Swati
full_name: Tyagi, Swati
last_name: Tyagi
- first_name: Ranjan
full_name: Ramachandra, Ranjan
last_name: Ramachandra
- first_name: Thomas
full_name: Deerinck, Thomas
last_name: Deerinck
- first_name: Eric
full_name: Bushong, Eric
last_name: Bushong
- first_name: Sebastien
full_name: Phan, Sebastien
last_name: Phan
- first_name: Victoria
full_name: Orphan, Victoria
last_name: Orphan
- first_name: Claude
full_name: Lechene, Claude
last_name: Lechene
- first_name: Mark H.
full_name: Ellisman, Mark H.
last_name: Ellisman
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Arrojo e Drigo R, Lev-Ram V, Tyagi S, et al. Age mosaicism across multiple
scales in adult tissues. Cell Metabolism. 2019;30(2):343-351.e3. doi:10.1016/j.cmet.2019.05.010
apa: Arrojo e Drigo, R., Lev-Ram, V., Tyagi, S., Ramachandra, R., Deerinck, T.,
Bushong, E., … Hetzer, M. (2019). Age mosaicism across multiple scales in adult
tissues. Cell Metabolism. Elsevier. https://doi.org/10.1016/j.cmet.2019.05.010
chicago: Arrojo e Drigo, Rafael, Varda Lev-Ram, Swati Tyagi, Ranjan Ramachandra,
Thomas Deerinck, Eric Bushong, Sebastien Phan, et al. “Age Mosaicism across Multiple
Scales in Adult Tissues.” Cell Metabolism. Elsevier, 2019. https://doi.org/10.1016/j.cmet.2019.05.010.
ieee: R. Arrojo e Drigo et al., “Age mosaicism across multiple scales in
adult tissues,” Cell Metabolism, vol. 30, no. 2. Elsevier, p. 343–351.e3,
2019.
ista: Arrojo e Drigo R, Lev-Ram V, Tyagi S, Ramachandra R, Deerinck T, Bushong E,
Phan S, Orphan V, Lechene C, Ellisman MH, Hetzer M. 2019. Age mosaicism across
multiple scales in adult tissues. Cell Metabolism. 30(2), 343–351.e3.
mla: Arrojo e Drigo, Rafael, et al. “Age Mosaicism across Multiple Scales in Adult
Tissues.” Cell Metabolism, vol. 30, no. 2, Elsevier, 2019, p. 343–351.e3,
doi:10.1016/j.cmet.2019.05.010.
short: R. Arrojo e Drigo, V. Lev-Ram, S. Tyagi, R. Ramachandra, T. Deerinck, E.
Bushong, S. Phan, V. Orphan, C. Lechene, M.H. Ellisman, M. Hetzer, Cell Metabolism
30 (2019) 343–351.e3.
date_created: 2022-04-07T07:45:21Z
date_published: 2019-08-06T00:00:00Z
date_updated: 2022-07-18T08:32:30Z
day: '06'
doi: 10.1016/j.cmet.2019.05.010
extern: '1'
external_id:
pmid:
- '31178361'
intvolume: ' 30'
issue: '2'
keyword:
- Cell Biology
- Molecular Biology
- Physiology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cmet.2019.05.010
month: '08'
oa: 1
oa_version: Published Version
page: 343-351.e3
pmid: 1
publication: Cell Metabolism
publication_identifier:
issn:
- 1550-4131
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Age mosaicism across multiple scales in adult tissues
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 30
year: '2019'
...
---
_id: '11059'
abstract:
- lang: eng
text: The genome is packaged and organized nonrandomly within the 3D space of the
nucleus to promote efficient gene expression and to faithfully maintain silencing
of heterochromatin. The genome is enclosed within the nucleus by the nuclear envelope
membrane, which contains a set of proteins that actively participate in chromatin
organization and gene regulation. Technological advances are providing views of
genome organization at unprecedented resolution and are beginning to reveal the
ways that cells co-opt the structures of the nuclear periphery for nuclear organization
and gene regulation. These genome regulatory roles of proteins of the nuclear
periphery have important influences on development, disease and ageing.
article_processing_charge: No
article_type: review
author:
- first_name: Abigail
full_name: Buchwalter, Abigail
last_name: Buchwalter
- first_name: Jeanae M.
full_name: Kaneshiro, Jeanae M.
last_name: Kaneshiro
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: 'Buchwalter A, Kaneshiro JM, Hetzer M. Coaching from the sidelines: The nuclear
periphery in genome regulation. Nature Reviews Genetics. 2019;20(1):39-50.
doi:10.1038/s41576-018-0063-5'
apa: 'Buchwalter, A., Kaneshiro, J. M., & Hetzer, M. (2019). Coaching from the
sidelines: The nuclear periphery in genome regulation. Nature Reviews Genetics.
Springer Nature. https://doi.org/10.1038/s41576-018-0063-5'
chicago: 'Buchwalter, Abigail, Jeanae M. Kaneshiro, and Martin Hetzer. “Coaching
from the Sidelines: The Nuclear Periphery in Genome Regulation.” Nature Reviews
Genetics. Springer Nature, 2019. https://doi.org/10.1038/s41576-018-0063-5.'
ieee: 'A. Buchwalter, J. M. Kaneshiro, and M. Hetzer, “Coaching from the sidelines:
The nuclear periphery in genome regulation,” Nature Reviews Genetics, vol.
20, no. 1. Springer Nature, pp. 39–50, 2019.'
ista: 'Buchwalter A, Kaneshiro JM, Hetzer M. 2019. Coaching from the sidelines:
The nuclear periphery in genome regulation. Nature Reviews Genetics. 20(1), 39–50.'
mla: 'Buchwalter, Abigail, et al. “Coaching from the Sidelines: The Nuclear Periphery
in Genome Regulation.” Nature Reviews Genetics, vol. 20, no. 1, Springer
Nature, 2019, pp. 39–50, doi:10.1038/s41576-018-0063-5.'
short: A. Buchwalter, J.M. Kaneshiro, M. Hetzer, Nature Reviews Genetics 20 (2019)
39–50.
date_created: 2022-04-07T07:44:45Z
date_published: 2019-01-01T00:00:00Z
date_updated: 2022-07-18T08:31:42Z
day: '01'
doi: 10.1038/s41576-018-0063-5
extern: '1'
external_id:
pmid:
- '30356165'
intvolume: ' 20'
issue: '1'
keyword:
- Genetics (clinical)
- Genetics
- Molecular Biology
language:
- iso: eng
month: '01'
oa_version: None
page: 39-50
pmid: 1
publication: Nature Reviews Genetics
publication_identifier:
eissn:
- 1471-0064
issn:
- 1471-0056
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Coaching from the sidelines: The nuclear periphery in genome regulation'
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 20
year: '2019'
...
---
_id: '11499'
abstract:
- lang: eng
text: Deep optical spectroscopic surveys of galaxies provide a unique opportunity
to investigate rest-frame ultra-violet (UV) emission line properties of galaxies
at z ∼ 2 − 4.5. Here we combine VLT/MUSE Guaranteed Time Observations of the Hubble
Deep Field South, Ultra Deep Field, COSMOS, and several quasar fields with other
publicly available data from VLT/VIMOS and VLT/FORS2 to construct a catalogue
of He II λ1640 emitters at z ≳ 2. The deepest areas of our MUSE pointings reach
a 3σ line flux limit of 3.1 × 10−19 erg s−1 cm−2. After discarding broad-line
active galactic nuclei, we find 13 He II λ1640 detections from MUSE with a median
MUV = −20.1 and 21 tentative He II λ1640 detections from other public surveys.
Excluding Lyα, all except two galaxies in our sample show at least one other rest-UV
emission line, with C III] λ1907, λ1909 being the most prominent. We use multi-wavelength
data available in the Hubble legacy fields to derive basic galaxy properties of
our sample through spectral energy distribution fitting techniques. Taking advantage
of the high-quality spectra obtained by MUSE (∼10 − 30 h of exposure time per
pointing), we use photo-ionisation models to study the rest-UV emission line diagnostics
of the He II λ1640 emitters. Line ratios of our sample can be reproduced by moderately
sub-solar photo-ionisation models, however, we find that including effects of
binary stars lead to degeneracies in most free parameters. Even after considering
extra ionising photons produced by extreme sub-solar metallicity binary stellar
models, photo-ionisation models are unable to reproduce rest-frame He II λ1640
equivalent widths (∼0.2 − 10 Å), thus additional mechanisms are necessary in models
to match the observed He II λ1640 properties.
acknowledgement: 'The authors wish to thank the referee for constructive comments
that improved the paper substantially. We thank the BPASS team for making the stellar
population models available. We thank Elizabeth Stanway, Claus Leitherer, Daniel
Schaerer, Jorick Vink, and Nell Byler for insightful discussions. We thank the Lorentz
Centre and the scientific organizers of the Characterizing galaxies with spectroscopy
with a view for JWST workshop held at the Lorentz Centre in 2017 October, which
promoted useful discussions in the wider community. TN, JB, and RB acknowledges
the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) top grant TOP1.16.057.
AF acknowledges support from the ERC via an Advanced Grant under grant agreement
no. 339659-MUSICOS. JB acknowledges support by Fundação para a Ciência e a Tecnologia
(FCT) through national funds (UID/FIS/04434/2013) and Investigador FCT contract
IF/01654/2014/CP1215/CT0003, and by FEDER through COMPETE2020 (POCI-01-0145-FEDER-007672).
JR acknowledges support from the ERC Starting grant 336736 (CALENDS). This research
made use of astropy (http://www.astropy.org) a community-developed core Python package
for Astronomy (Astropy Collaboration 2013, 2018) and pandas (McKinney 2010). Figures
were generated using matplotlib (Hunter 2007) and seaborn (https://seaborn.pydata.org).
Facilities: VLT (MUSE).'
article_number: A89
article_processing_charge: No
article_type: original
author:
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
- first_name: Jarle
full_name: Brinchmann, Jarle
last_name: Brinchmann
- first_name: Leindert
full_name: Boogaard, Leindert
last_name: Boogaard
- first_name: Rychard
full_name: Bouwens, Rychard
last_name: Bouwens
- first_name: Sebastiano
full_name: Cantalupo, Sebastiano
last_name: Cantalupo
- first_name: Anna
full_name: Feltre, Anna
last_name: Feltre
- first_name: Wolfram
full_name: Kollatschny, Wolfram
last_name: Kollatschny
- first_name: Raffaella Anna
full_name: Marino, Raffaella Anna
last_name: Marino
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Mieke
full_name: Paalvast, Mieke
last_name: Paalvast
- first_name: Johan
full_name: Richard, Johan
last_name: Richard
- first_name: Anne
full_name: Verhamme, Anne
last_name: Verhamme
citation:
ama: Nanayakkara T, Brinchmann J, Boogaard L, et al. Exploring He II λ1640 emission
line properties at z ∼2−4. Astronomy & Astrophysics. 2019;648. doi:10.1051/0004-6361/201834565
apa: Nanayakkara, T., Brinchmann, J., Boogaard, L., Bouwens, R., Cantalupo, S.,
Feltre, A., … Verhamme, A. (2019). Exploring He II λ1640 emission line properties
at z ∼2−4. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/201834565
chicago: Nanayakkara, Themiya, Jarle Brinchmann, Leindert Boogaard, Rychard Bouwens,
Sebastiano Cantalupo, Anna Feltre, Wolfram Kollatschny, et al. “Exploring He II Λ1640
Emission Line Properties at z ∼2−4.” Astronomy & Astrophysics. EDP
Sciences, 2019. https://doi.org/10.1051/0004-6361/201834565.
ieee: T. Nanayakkara et al., “Exploring He II λ1640 emission line properties
at z ∼2−4,” Astronomy & Astrophysics, vol. 648. EDP Sciences, 2019.
ista: Nanayakkara T, Brinchmann J, Boogaard L, Bouwens R, Cantalupo S, Feltre A,
Kollatschny W, Marino RA, Maseda M, Matthee JJ, Paalvast M, Richard J, Verhamme
A. 2019. Exploring He II λ1640 emission line properties at z ∼2−4. Astronomy &
Astrophysics. 648, A89.
mla: Nanayakkara, Themiya, et al. “Exploring He II Λ1640 Emission Line Properties
at z ∼2−4.” Astronomy & Astrophysics, vol. 648, A89, EDP Sciences,
2019, doi:10.1051/0004-6361/201834565.
short: T. Nanayakkara, J. Brinchmann, L. Boogaard, R. Bouwens, S. Cantalupo, A.
Feltre, W. Kollatschny, R.A. Marino, M. Maseda, J.J. Matthee, M. Paalvast, J.
Richard, A. Verhamme, Astronomy & Astrophysics 648 (2019).
date_created: 2022-07-06T09:07:06Z
date_published: 2019-04-16T00:00:00Z
date_updated: 2022-07-19T09:36:08Z
day: '16'
doi: 10.1051/0004-6361/201834565
extern: '1'
external_id:
arxiv:
- '1902.05960'
intvolume: ' 648'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: ISM / galaxies: star formation / galaxies: evolution / galaxies: high-redshift'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1902.05960
month: '04'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1051/0004-6361/201834565e
scopus_import: '1'
status: public
title: Exploring He II λ1640 emission line properties at z ∼2−4
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 648
year: '2019'
...
---
_id: '11505'
abstract:
- lang: eng
text: "Contact. This paper presents the results obtained with the Multi-Unit Spectroscopic
Explorer (MUSE) at the ESO Very Large Telescope on the faint end of the Lyman-alpha
luminosity function (LF) based on deep observations of four lensing clusters.
The goal of our project is to set strong constraints on the relative contribution
of the Lyman-alpha emitter (LAE) population to cosmic reionization.\r\n\r\nAims.
The precise aim of the present study is to further constrain the abundance of
LAEs by taking advantage of the magnification provided by lensing clusters to
build a blindly selected sample of galaxies which is less biased than current
blank field samples in redshift and luminosity. By construction, this sample of
LAEs is complementary to those built from deep blank fields, whether observed
by MUSE or by other facilities, and makes it possible to determine the shape of
the LF at fainter levels, as well as its evolution with redshift.\r\n\r\nMethods.
We selected a sample of 156 LAEs with redshifts between 2.9 ≤ z ≤ 6.7 and magnification-corrected
luminosities in the range 39 ≲ log LLyα [erg s−1] ≲43. To properly take into account
the individual differences in detection conditions between the LAEs when computing
the LF, including lensing configurations, and spatial and spectral morphologies,
the non-parametric 1/Vmax method was adopted. The price to pay to benefit from
magnification is a reduction of the effective volume of the survey, together with
a more complex analysis procedure to properly determine the effective volume Vmax
for each galaxy. In this paper we present a complete procedure for the determination
of the LF based on IFU detections in lensing clusters. This procedure, including
some new methods for masking, effective volume integration and (individual) completeness
determinations, has been fully automated when possible, and it can be easily generalized
to the analysis of IFU observations in blank fields.\r\n\r\nResults. As a result
of this analysis, the Lyman-alpha LF has been obtained in four different redshift
bins: 2.9 < z < 6, 7, 2.9 < z < 4.0, 4.0 < z < 5.0, and 5.0 < z < 6.7
with constraints down to log LLyα = 40.5. From our data only, no significant evolution
of LF mean slope can be found. When performing a Schechter analysis also including
data from the literature to complete the present sample towards the brightest
luminosities, a steep faint end slope was measured varying from α = −1.69−0.08+0.08
to α = −1.87−0.12+0.12 between the lowest and the highest redshift bins.\r\n\r\nConclusions.
The contribution of the LAE population to the star formation rate density at z ∼ 6
is ≲50% depending on the luminosity limit considered, which is of the same order
as the Lyman-break galaxy (LBG) contribution. The evolution of the LAE contribution
with redshift depends on the assumed escape fraction of Lyman-alpha photons, and
appears to slightly increase with increasing redshift when this fraction is conservatively
set to one. Depending on the intersection between the LAE/LBG populations, the
contribution of the observed galaxies to the ionizing flux may suffice to keep
the universe ionized at z ∼ 6."
acknowledgement: We thank the anonymous referee for their critical review and useful
suggestions. This work has been carried out thanks to the support of the OCEVU Labex
(ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02) funded by the “Investissements
d’Avenir” French government programme managed by the ANR. Partially funded by the
ERC starting grant CALENDS (JR, VP, BC, JM), the Agence Nationale de la recherche
bearing the reference ANR-13-BS05-0010-02 (FOGHAR), and the “Programme National
de Cosmologie and Galaxies” (PNCG) of CNRS/INSU, France. GdV, RP, JR, GM, JM, BC,
and VP also acknowledge support by the Programa de Cooperacion Cientifica – ECOS
SUD Program C16U02. NL acknowledges funding from the European Research Council (ERC)
under the European Union’s Horizon 2020 research and innovation programme (grant
agreement No 669253), ABD acknowledges support from the ERC advanced grant “Cosmic
Gas”. LW acknowledges support by the Competitive Fund of the Leibniz Association
through grant SAW-2015-AIP-2, and TG acknowledges support from the European Research
Council under grant agreement ERC-stg-757258 (TRIPLE).. Based on observations made
with ESO Telescopes at the La Silla Paranal Observatory under programme IDs 060.A-9345,
094.A-0115, 095.A-0181, 096.A-0710, 097.A0269, 100.A-0249, and 294.A-5032. Also
based on observations obtained with the NASA/ESA Hubble Space Telescope, retrieved
from the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science
Institute (STScI). STScI is operated by the Association of Universities for Research
in Astronomy, Inc. under NASA contract NAS 5-26555. This research made use of Astropy,
a community-developed core Python package for Astronomy (Astropy Collaboration 2013).
All plots in this paper were created using Matplotlib (Hunter 2007).
article_number: A3
article_processing_charge: No
article_type: original
author:
- first_name: G.
full_name: de La Vieuville, G.
last_name: de La Vieuville
- first_name: D.
full_name: Bina, D.
last_name: Bina
- first_name: R.
full_name: Pello, R.
last_name: Pello
- first_name: G.
full_name: Mahler, G.
last_name: Mahler
- first_name: J.
full_name: Richard, J.
last_name: Richard
- first_name: A. B.
full_name: Drake, A. B.
last_name: Drake
- first_name: E. C.
full_name: Herenz, E. C.
last_name: Herenz
- first_name: F. E.
full_name: Bauer, F. E.
last_name: Bauer
- first_name: B.
full_name: Clément, B.
last_name: Clément
- first_name: D.
full_name: Lagattuta, D.
last_name: Lagattuta
- first_name: N.
full_name: Laporte, N.
last_name: Laporte
- first_name: J.
full_name: Martinez, J.
last_name: Martinez
- first_name: V.
full_name: Patrício, V.
last_name: Patrício
- first_name: L.
full_name: Wisotzki, L.
last_name: Wisotzki
- first_name: J.
full_name: Zabl, J.
last_name: Zabl
- first_name: R. J.
full_name: Bouwens, R. J.
last_name: Bouwens
- first_name: T.
full_name: Contini, T.
last_name: Contini
- first_name: T.
full_name: Garel, T.
last_name: Garel
- first_name: B.
full_name: Guiderdoni, B.
last_name: Guiderdoni
- first_name: R. A.
full_name: Marino, R. A.
last_name: Marino
- first_name: M. V.
full_name: Maseda, M. V.
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: J.
full_name: Schaye, J.
last_name: Schaye
- first_name: G.
full_name: Soucail, G.
last_name: Soucail
citation:
ama: de La Vieuville G, Bina D, Pello R, et al. Faint end of the z ∼ 3–7 luminosity
function of Lyman-alpha emitters behind lensing clusters observed with MUSE. Astronomy
& Astrophysics. 2019;628. doi:10.1051/0004-6361/201834471
apa: de La Vieuville, G., Bina, D., Pello, R., Mahler, G., Richard, J., Drake, A.
B., … Soucail, G. (2019). Faint end of the z ∼ 3–7 luminosity function of Lyman-alpha
emitters behind lensing clusters observed with MUSE. Astronomy & Astrophysics.
EDP Sciences. https://doi.org/10.1051/0004-6361/201834471
chicago: La Vieuville, G. de, D. Bina, R. Pello, G. Mahler, J. Richard, A. B. Drake,
E. C. Herenz, et al. “Faint End of the z ∼ 3–7 Luminosity Function of Lyman-Alpha
Emitters behind Lensing Clusters Observed with MUSE.” Astronomy & Astrophysics.
EDP Sciences, 2019. https://doi.org/10.1051/0004-6361/201834471.
ieee: G. de La Vieuville et al., “Faint end of the z ∼ 3–7 luminosity function
of Lyman-alpha emitters behind lensing clusters observed with MUSE,” Astronomy
& Astrophysics, vol. 628. EDP Sciences, 2019.
ista: de La Vieuville G, Bina D, Pello R, Mahler G, Richard J, Drake AB, Herenz
EC, Bauer FE, Clément B, Lagattuta D, Laporte N, Martinez J, Patrício V, Wisotzki
L, Zabl J, Bouwens RJ, Contini T, Garel T, Guiderdoni B, Marino RA, Maseda MV,
Matthee JJ, Schaye J, Soucail G. 2019. Faint end of the z ∼ 3–7 luminosity function
of Lyman-alpha emitters behind lensing clusters observed with MUSE. Astronomy
& Astrophysics. 628, A3.
mla: de La Vieuville, G., et al. “Faint End of the z ∼ 3–7 Luminosity Function of
Lyman-Alpha Emitters behind Lensing Clusters Observed with MUSE.” Astronomy
& Astrophysics, vol. 628, A3, EDP Sciences, 2019, doi:10.1051/0004-6361/201834471.
short: G. de La Vieuville, D. Bina, R. Pello, G. Mahler, J. Richard, A.B. Drake,
E.C. Herenz, F.E. Bauer, B. Clément, D. Lagattuta, N. Laporte, J. Martinez, V.
Patrício, L. Wisotzki, J. Zabl, R.J. Bouwens, T. Contini, T. Garel, B. Guiderdoni,
R.A. Marino, M.V. Maseda, J.J. Matthee, J. Schaye, G. Soucail, Astronomy &
Astrophysics 628 (2019).
date_created: 2022-07-06T10:09:36Z
date_published: 2019-07-25T00:00:00Z
date_updated: 2022-07-19T09:36:31Z
day: '25'
doi: 10.1051/0004-6361/201834471
extern: '1'
external_id:
arxiv:
- '1905.13696'
intvolume: ' 628'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'gravitational lensing: strong / galaxies: high-redshift / dark ages'
- reionization
- 'first stars / galaxies: clusters: general / galaxies: luminosity function'
- mass function
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1905.13696
month: '07'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Faint end of the z ∼ 3–7 luminosity function of Lyman-alpha emitters behind
lensing clusters observed with MUSE
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 628
year: '2019'
...
---
_id: '11507'
abstract:
- lang: eng
text: 'Lyman-α (Lyα) is intrinsically the brightest line emitted from active galaxies.
While it originates from many physical processes, for star-forming galaxies the
intrinsic Lyα luminosity is a direct tracer of the Lyman-continuum (LyC) radiation
produced by the most massive O- and early-type B-stars (M⋆ ≳ 10 M⊙) with lifetimes
of a few Myrs. As such, Lyα luminosity should be an excellent instantaneous star
formation rate (SFR) indicator. However, its resonant nature and susceptibility
to dust as a rest-frame UV photon makes Lyα very hard to interpret due to the
uncertain Lyα escape fraction, fesc, Lyα. Here we explore results from the CAlibrating
LYMan-α with Hα (CALYMHA) survey at z = 2.2, follow-up of Lyα emitters (LAEs)
at z = 2.2 − 2.6 and a z ∼ 0−0.3 compilation of LAEs to directly measure fesc, Lyα
with Hα. We derive a simple empirical relation that robustly retrieves fesc, Lyα
as a function of Lyα rest-frame EW (EW0): fesc,Lyα = 0.0048 EW0[Å] ± 0.05 and
we show that it constrains a well-defined anti-correlation between ionisation
efficiency (ξion) and dust extinction in LAEs. Observed Lyα luminosities and EW0
are easy measurable quantities at high redshift, thus making our relation a practical
tool to estimate intrinsic Lyα and LyC luminosities under well controlled and
simple assumptions. Our results allow observed Lyα luminosities to be used to
compute SFRs for LAEs at z ∼ 0−2.6 within ±0.2 dex of the Hα dust corrected SFRs.
We apply our empirical SFR(Lyα,EW0) calibration to several sources at z ≥ 2.6
to find that star-forming LAEs have SFRs typically ranging from 0.1 to 20 M⊙ yr−1
and that our calibration might be even applicable for the most luminous LAEs within
the epoch of re-ionisation. Our results imply high ionisation efficiencies (log10[ξion/Hz erg−1]
= 25.4−25.6) and low dust content in LAEs across cosmic time, and will be easily
tested with future observations with JWST which can obtain Hα and Hβ measurements
for high-redshift LAEs.'
acknowledgement: We thank the anonymous referees for multiple comments and suggestions
which have improved the manuscript. JM acknowledges the support of a Huygens PhD
fellowship from Leiden University. We have benefited greatly from the publicly available
programming language PYTHON, including the NUMPY & SCIPY (Van Der Walt et al. 2011;
Jones et al. 2001), MATPLOTLIB (Hunter 2007) and ASTROPY (Astropy Collaboration
2013) packages, and the TOPCAT analysis program (Taylor 2013). The results and samples
of LAEs used for this paper are publicly available (see e.g. Sobral et al. 2017,
2018a) and we also provide the toy model used as a PYTHON script.
article_number: A157
article_processing_charge: No
article_type: original
author:
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: 'Sobral D, Matthee JJ. Predicting Lyα escape fractions with a simple observable:
Lyα in emission as an empirically calibrated star formation rate indicator. Astronomy
& Astrophysics. 2019;623. doi:10.1051/0004-6361/201833075'
apa: 'Sobral, D., & Matthee, J. J. (2019). Predicting Lyα escape fractions with
a simple observable: Lyα in emission as an empirically calibrated star formation
rate indicator. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/201833075'
chicago: 'Sobral, David, and Jorryt J Matthee. “Predicting Lyα Escape Fractions
with a Simple Observable: Lyα in Emission as an Empirically Calibrated Star Formation
Rate Indicator.” Astronomy & Astrophysics. EDP Sciences, 2019. https://doi.org/10.1051/0004-6361/201833075.'
ieee: 'D. Sobral and J. J. Matthee, “Predicting Lyα escape fractions with a simple
observable: Lyα in emission as an empirically calibrated star formation rate indicator,”
Astronomy & Astrophysics, vol. 623. EDP Sciences, 2019.'
ista: 'Sobral D, Matthee JJ. 2019. Predicting Lyα escape fractions with a simple
observable: Lyα in emission as an empirically calibrated star formation rate indicator.
Astronomy & Astrophysics. 623, A157.'
mla: 'Sobral, David, and Jorryt J. Matthee. “Predicting Lyα Escape Fractions with
a Simple Observable: Lyα in Emission as an Empirically Calibrated Star Formation
Rate Indicator.” Astronomy & Astrophysics, vol. 623, A157, EDP Sciences,
2019, doi:10.1051/0004-6361/201833075.'
short: D. Sobral, J.J. Matthee, Astronomy & Astrophysics 623 (2019).
date_created: 2022-07-06T11:08:16Z
date_published: 2019-03-26T00:00:00Z
date_updated: 2022-07-19T09:37:20Z
day: '26'
doi: 10.1051/0004-6361/201833075
extern: '1'
external_id:
arxiv:
- '1803.08923'
intvolume: ' 623'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift / galaxies: star formation / galaxies: statistics / galaxies:
evolution / galaxies: formation / galaxies: ISM'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1803.08923
month: '03'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Predicting Lyα escape fractions with a simple observable: Lyα in emission
as an empirically calibrated star formation rate indicator'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 623
year: '2019'
...
---
_id: '11514'
abstract:
- lang: eng
text: We discuss the nature and physical properties of gas-mass selected galaxies
in the ALMA spectroscopic survey (ASPECS) of the Hubble Ultra Deep Field (HUDF).
We capitalize on the deep optical integral-field spectroscopy from the Multi Unit
Spectroscopic Explorer (MUSE) HUDF Survey and multiwavelength data to uniquely
associate all 16 line emitters, detected in the ALMA data without preselection,
with rotational transitions of carbon monoxide (CO). We identify 10 as CO(2–1)
at 1 < z < 2, 5 as CO(3–2) at 2 < z < 3, and 1 as CO(4–3) at z = 3.6. Using the
MUSE data as a prior, we identify two additional CO(2–1) emitters, increasing
the total sample size to 18. We infer metallicities consistent with (super-)solar
for the CO-detected galaxies at z ≤ 1.5, motivating our choice of a Galactic conversion
factor between CO luminosity and molecular gas mass for these galaxies. Using
deep Chandra imaging of the HUDF, we determine an X-ray AGN fraction of 20% and
60% among the CO emitters at z ∼ 1.4 and z ∼ 2.6, respectively. Being a CO-flux-limited
survey, ASPECS-LP detects molecular gas in galaxies on, above, and below the main
sequence (MS) at z ∼ 1.4. For stellar masses ≥1010 (1010.5) ${M}_{\odot }$, we
detect about 40% (50%) of all galaxies in the HUDF at 1 < z < 2 (2 < z < 3). The
combination of ALMA and MUSE integral-field spectroscopy thus enables an unprecedented
view of MS galaxies during the peak of galaxy formation.
acknowledgement: "We are grateful to the referee for providing a constructive report.
L.A.B. wants to thank Madusha L.P. Gunawardhana for her help with platefit. Based
on observations collected at the European Southern Observatory under ESO programme(s):
094.A-2089(B), 095.A-0010(A), 096.A-0045(A), and 096.A-0045(B). This paper makes
use of the following ALMA data: ADS/JAO.ALMA#2016.1.00324.L. ALMA is a partnership
of ESO (representing its member states), NSF (USA) and NINS (Japan), together with
NRC (Canada), NSC and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation
with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO,
and NAOJ. The National Radio Astronomy Observatory is a facility of the National
Science Foundation operated under cooperative agreement by Associated Universities,
Inc.\r\n\r\n\"Este trabajo contó con el apoyo de CONICYT+Programa de Astronomía+
Fondo CHINA-CONICYT\" J.G-L. acknowledges partial support from ALMA-CONICYT project
31160033. F.E.B. acknowledges support from CONICYT grant Basal AFB-170002 (FEB),
and the Ministry of Economy, Development, and Tourism's Millennium Science Initiative
through grant IC120009, awarded to The Millennium Institute of Astrophysics, MAS
(FEB). J.B. acknowledges support by Fundação para a Ciência e a Tecnologia (FCT)
through national funds (UID/FIS/04434/2013) and Investigador FCT contract IF/01654/2014/CP1215/CT0003.,
and by FEDER through COMPETE2020 (POCI-01-0145-FEDER-007672). T.D-S. acknowledges
support from ALMA-CONYCIT project 31130005 and FONDECYT project 1151239. J.H. acknowledges
support of the VIDI research programme with project number 639.042.611, which is
(partly) financed by the Netherlands Organization for Scientific Research (NWO).
D.R. acknowledges support from the National Science Foundation under grant No. AST-1614213.
I.R.S. acknowledges support from the ERC Advanced Grant DUSTYGAL (321334) and STFC
(ST/P000541/1)\r\n\r\nWork on Gnuastro has been funded by the Japanese MEXT scholarship
and its Grant-in-Aid for Scientific Research (21244012, 24253003), the ERC advanced
grant 339659-MUSICOS, European Union's Horizon 2020 research and innovation programme
under Marie Sklodowska-Curie grant agreement No. 721463 to the SUNDIAL ITN, and
from the Spanish MINECO under grant No. AYA2016-76219-P."
article_number: '140'
article_processing_charge: No
article_type: original
author:
- first_name: Leindert A.
full_name: Boogaard, Leindert A.
last_name: Boogaard
- first_name: Roberto
full_name: Decarli, Roberto
last_name: Decarli
- first_name: Jorge
full_name: González-López, Jorge
last_name: González-López
- first_name: Paul
full_name: van der Werf, Paul
last_name: van der Werf
- first_name: Fabian
full_name: Walter, Fabian
last_name: Walter
- first_name: Rychard
full_name: Bouwens, Rychard
last_name: Bouwens
- first_name: Manuel
full_name: Aravena, Manuel
last_name: Aravena
- first_name: Chris
full_name: Carilli, Chris
last_name: Carilli
- first_name: Franz Erik
full_name: Bauer, Franz Erik
last_name: Bauer
- first_name: Jarle
full_name: Brinchmann, Jarle
last_name: Brinchmann
- first_name: Thierry
full_name: Contini, Thierry
last_name: Contini
- first_name: Pierre
full_name: Cox, Pierre
last_name: Cox
- first_name: Elisabete
full_name: da Cunha, Elisabete
last_name: da Cunha
- first_name: Emanuele
full_name: Daddi, Emanuele
last_name: Daddi
- first_name: Tanio
full_name: Díaz-Santos, Tanio
last_name: Díaz-Santos
- first_name: Jacqueline
full_name: Hodge, Jacqueline
last_name: Hodge
- first_name: Hanae
full_name: Inami, Hanae
last_name: Inami
- first_name: Rob
full_name: Ivison, Rob
last_name: Ivison
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Pascal
full_name: Oesch, Pascal
last_name: Oesch
- first_name: Gergö
full_name: Popping, Gergö
last_name: Popping
- first_name: Dominik
full_name: Riechers, Dominik
last_name: Riechers
- first_name: Joop
full_name: Schaye, Joop
last_name: Schaye
- first_name: Sander
full_name: Schouws, Sander
last_name: Schouws
- first_name: Ian
full_name: Smail, Ian
last_name: Smail
- first_name: Axel
full_name: Weiss, Axel
last_name: Weiss
- first_name: Lutz
full_name: Wisotzki, Lutz
last_name: Wisotzki
- first_name: Roland
full_name: Bacon, Roland
last_name: Bacon
- first_name: Paulo C.
full_name: Cortes, Paulo C.
last_name: Cortes
- first_name: Hans-Walter
full_name: Rix, Hans-Walter
last_name: Rix
- first_name: Rachel S.
full_name: Somerville, Rachel S.
last_name: Somerville
- first_name: Mark
full_name: Swinbank, Mark
last_name: Swinbank
- first_name: Jeff
full_name: Wagg, Jeff
last_name: Wagg
citation:
ama: 'Boogaard LA, Decarli R, González-López J, et al. The ALMA spectroscopic survey
in the HUDF: Nature and physical properties of gas-mass selected galaxies using
MUSE spectroscopy. The Astrophysical Journal. 2019;882(2). doi:10.3847/1538-4357/ab3102'
apa: 'Boogaard, L. A., Decarli, R., González-López, J., van der Werf, P., Walter,
F., Bouwens, R., … Wagg, J. (2019). The ALMA spectroscopic survey in the HUDF:
Nature and physical properties of gas-mass selected galaxies using MUSE spectroscopy.
The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ab3102'
chicago: 'Boogaard, Leindert A., Roberto Decarli, Jorge González-López, Paul van
der Werf, Fabian Walter, Rychard Bouwens, Manuel Aravena, et al. “The ALMA Spectroscopic
Survey in the HUDF: Nature and Physical Properties of Gas-Mass Selected Galaxies
Using MUSE Spectroscopy.” The Astrophysical Journal. IOP Publishing, 2019.
https://doi.org/10.3847/1538-4357/ab3102.'
ieee: 'L. A. Boogaard et al., “The ALMA spectroscopic survey in the HUDF:
Nature and physical properties of gas-mass selected galaxies using MUSE spectroscopy,”
The Astrophysical Journal, vol. 882, no. 2. IOP Publishing, 2019.'
ista: 'Boogaard LA, Decarli R, González-López J, van der Werf P, Walter F, Bouwens
R, Aravena M, Carilli C, Bauer FE, Brinchmann J, Contini T, Cox P, da Cunha E,
Daddi E, Díaz-Santos T, Hodge J, Inami H, Ivison R, Maseda M, Matthee JJ, Oesch
P, Popping G, Riechers D, Schaye J, Schouws S, Smail I, Weiss A, Wisotzki L, Bacon
R, Cortes PC, Rix H-W, Somerville RS, Swinbank M, Wagg J. 2019. The ALMA spectroscopic
survey in the HUDF: Nature and physical properties of gas-mass selected galaxies
using MUSE spectroscopy. The Astrophysical Journal. 882(2), 140.'
mla: 'Boogaard, Leindert A., et al. “The ALMA Spectroscopic Survey in the HUDF:
Nature and Physical Properties of Gas-Mass Selected Galaxies Using MUSE Spectroscopy.”
The Astrophysical Journal, vol. 882, no. 2, 140, IOP Publishing, 2019,
doi:10.3847/1538-4357/ab3102.'
short: L.A. Boogaard, R. Decarli, J. González-López, P. van der Werf, F. Walter,
R. Bouwens, M. Aravena, C. Carilli, F.E. Bauer, J. Brinchmann, T. Contini, P.
Cox, E. da Cunha, E. Daddi, T. Díaz-Santos, J. Hodge, H. Inami, R. Ivison, M.
Maseda, J.J. Matthee, P. Oesch, G. Popping, D. Riechers, J. Schaye, S. Schouws,
I. Smail, A. Weiss, L. Wisotzki, R. Bacon, P.C. Cortes, H.-W. Rix, R.S. Somerville,
M. Swinbank, J. Wagg, The Astrophysical Journal 882 (2019).
date_created: 2022-07-06T13:31:35Z
date_published: 2019-09-11T00:00:00Z
date_updated: 2022-07-19T09:50:55Z
day: '11'
doi: 10.3847/1538-4357/ab3102
extern: '1'
external_id:
arxiv:
- '1903.09167'
intvolume: ' 882'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1903.09167
month: '09'
oa: 1
oa_version: Preprint
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The ALMA spectroscopic survey in the HUDF: Nature and physical properties
of gas-mass selected galaxies using MUSE spectroscopy'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 882
year: '2019'
...
---
_id: '11516'
abstract:
- lang: eng
text: The well-known quasar SDSS J095253.83+011421.9 (J0952+0114) at z = 3.02 has
one of the most peculiar spectra discovered so far, showing the presence of narrow
Lyα and broad metal emission lines. Although recent studies have suggested that
a proximate damped Lyα absorption (PDLA) system causes this peculiar spectrum,
the origin of the gas associated with the PDLA is unknown. Here we report the
results of observations with the Multi Unit Spectroscopic Explorer (MUSE) that
reveal a new giant (≈100 physical kpc) Lyα nebula. The detailed analysis of the
Lyα velocity, velocity dispersion, and surface brightness profiles suggests that
the J0952+0114 Lyα nebula shares similar properties with other QSO nebulae previously
detected with MUSE, implying that the PDLA in J0952+0144 is covering only a small
fraction of the solid angle of the QSO emission. We also detected bright and spectrally
narrow C iv λ1550 and He ii λ1640 extended emission around J0952+0114 with velocity
centroids similar to the peak of the extended and central narrow Lyα emission.
The presence of a peculiarly bright, unresolved, and relatively broad He ii λ1640
emission in the central region at exactly the same PDLA redshift hints at the
possibility that the PDLA originates in a clumpy outflow with a bulk velocity
of about 500 km s−1. The smaller velocity dispersion of the large-scale Lyα emission
suggests that the high-speed outflow is confined to the central region. Lastly,
the derived spatially resolved He ii/Lyα and C iv/Lyα maps show a positive gradient
with the distance to the QSO, hinting at a non-homogeneous distribution of the
ionization parameter.
acknowledgement: We thank Lutz Wisotzki for stimulating discussions. This work is
based on observations taken at ESO/VLT in Paranal and we would like to thank the
ESO staff for their assistance and support during the MUSE GTO campaigns. This work
was supported by the Swiss National Science Foundation. This research made use of
Astropy, a community-developed core PYTHON package for astronomy (Astropy Collaboration
et al. 2013), NumPy and SciPy (Oliphant 2007), Matplotlib (Hunter 2007), IPython
(Perez & Granger 2007), and of the NASA Astrophysics Data System Bibliographic Services.
S.C. and G.P. gratefully acknowledge support from Swiss National Science Foundation
grant PP00P2−163824. A.F. acknowledges support from the ERC via Advanced Grant under
grants agreement no. 339659-MUSICOS. J.B. acknowledges support by FCT/MCTES through
national funds by grant UID/FIS/04434/2019 and through Investigador FCT Contract
No. IF/01654/2014/CP1215/CT0003. S.D.J. is supported by a NASA Hubble Fellowship
(HST-HF2-51375.001-A). T.N. acknowledges the Nederlandse Organisatie voor Wetenschappelijk
Onderzoek (NWO) top grant TOP1.16.057.
article_number: '47'
article_processing_charge: No
article_type: original
author:
- first_name: Raffaella Anna
full_name: Marino, Raffaella Anna
last_name: Marino
- first_name: Sebastiano
full_name: Cantalupo, Sebastiano
last_name: Cantalupo
- first_name: Gabriele
full_name: Pezzulli, Gabriele
last_name: Pezzulli
- first_name: Simon J.
full_name: Lilly, Simon J.
last_name: Lilly
- first_name: Sofia
full_name: Gallego, Sofia
last_name: Gallego
- first_name: Ruari
full_name: Mackenzie, Ruari
last_name: Mackenzie
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Jarle
full_name: Brinchmann, Jarle
last_name: Brinchmann
- first_name: Nicolas
full_name: Bouché, Nicolas
last_name: Bouché
- first_name: Anna
full_name: Feltre, Anna
last_name: Feltre
- first_name: Sowgat
full_name: Muzahid, Sowgat
last_name: Muzahid
- first_name: Ilane
full_name: Schroetter, Ilane
last_name: Schroetter
- first_name: Sean D.
full_name: Johnson, Sean D.
last_name: Johnson
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
citation:
ama: Marino RA, Cantalupo S, Pezzulli G, et al. A giant Lyα nebula and a small-scale
clumpy outflow in the system of the exotic quasar J0952+0114 unveiled by MUSE.
The Astrophysical Journal. 2019;880(1). doi:10.3847/1538-4357/ab2881
apa: Marino, R. A., Cantalupo, S., Pezzulli, G., Lilly, S. J., Gallego, S., Mackenzie,
R., … Nanayakkara, T. (2019). A giant Lyα nebula and a small-scale clumpy outflow
in the system of the exotic quasar J0952+0114 unveiled by MUSE. The Astrophysical
Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ab2881
chicago: Marino, Raffaella Anna, Sebastiano Cantalupo, Gabriele Pezzulli, Simon
J. Lilly, Sofia Gallego, Ruari Mackenzie, Jorryt J Matthee, et al. “A Giant Lyα
Nebula and a Small-Scale Clumpy Outflow in the System of the Exotic Quasar J0952+0114
Unveiled by MUSE.” The Astrophysical Journal. IOP Publishing, 2019. https://doi.org/10.3847/1538-4357/ab2881.
ieee: R. A. Marino et al., “A giant Lyα nebula and a small-scale clumpy outflow
in the system of the exotic quasar J0952+0114 unveiled by MUSE,” The Astrophysical
Journal, vol. 880, no. 1. IOP Publishing, 2019.
ista: Marino RA, Cantalupo S, Pezzulli G, Lilly SJ, Gallego S, Mackenzie R, Matthee
JJ, Brinchmann J, Bouché N, Feltre A, Muzahid S, Schroetter I, Johnson SD, Nanayakkara
T. 2019. A giant Lyα nebula and a small-scale clumpy outflow in the system of
the exotic quasar J0952+0114 unveiled by MUSE. The Astrophysical Journal. 880(1),
47.
mla: Marino, Raffaella Anna, et al. “A Giant Lyα Nebula and a Small-Scale Clumpy
Outflow in the System of the Exotic Quasar J0952+0114 Unveiled by MUSE.” The
Astrophysical Journal, vol. 880, no. 1, 47, IOP Publishing, 2019, doi:10.3847/1538-4357/ab2881.
short: R.A. Marino, S. Cantalupo, G. Pezzulli, S.J. Lilly, S. Gallego, R. Mackenzie,
J.J. Matthee, J. Brinchmann, N. Bouché, A. Feltre, S. Muzahid, I. Schroetter,
S.D. Johnson, T. Nanayakkara, The Astrophysical Journal 880 (2019).
date_created: 2022-07-06T13:50:33Z
date_published: 2019-07-24T00:00:00Z
date_updated: 2022-08-18T10:20:18Z
day: '24'
doi: 10.3847/1538-4357/ab2881
extern: '1'
external_id:
arxiv:
- '1906.06347'
intvolume: ' 880'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1906.06347
month: '07'
oa: 1
oa_version: Preprint
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: A giant Lyα nebula and a small-scale clumpy outflow in the system of the exotic
quasar J0952+0114 unveiled by MUSE
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 880
year: '2019'
...
---
_id: '11515'
abstract:
- lang: eng
text: We present new deep ALMA and Hubble Space Telescope (HST)/WFC3 observations
of MASOSA and VR7, two luminous Lyα emitters (LAEs) at z = 6.5, for which the
UV continuum levels differ by a factor of four. No IR dust continuum emission
is detected in either, indicating little amounts of obscured star formation and/or
high dust temperatures. MASOSA, with a UV luminosity M1500 = −20.9, compact size,
and very high Lyα ${\mathrm{EW}}_{0}\approx 145\,\mathring{\rm A} $, is undetected
in [C ii] to a limit of L[C ii] < 2.2 × 107 L⊙, implying a metallicity Z ≲ 0.07
Z⊙. Intriguingly, our HST data indicate a red UV slope β = −1.1 ± 0.7, at odds
with the low dust content. VR7, which is a bright (M1500 = −22.4) galaxy with
moderate color (β = −1.4 ± 0.3) and Lyα EW0 = 34 Å, is clearly detected in [C
ii] emission (S/N = 15). VR7's rest-frame UV morphology can be described by two
components separated by ≈1.5 kpc and is globally more compact than the [C ii]
emission. The global [C ii]/UV ratio indicates Z ≈ 0.2 Z⊙, but there are large
variations in the UV/[C ii] ratio on kiloparsec scales. We also identify diffuse,
possibly outflowing, [C ii]-emitting gas at ≈100 km s−1 with respect to the peak.
VR7 appears to be assembling its components at a slightly more evolved stage than
other luminous LAEs, with outflows already shaping its direct environment at z
∼ 7. Our results further indicate that the global [C ii]−UV relation steepens
at SFR < 30 M⊙ yr−1, naturally explaining why the [C ii]/UV ratio is anticorrelated
with Lyα EW in many, but not all, observed LAEs.
acknowledgement: 'We thank the anonymous referee for constructive comments and suggestions.
We thank Max Gronke for comments on an earlier version of this paper. L.V. acknowledges
funding from the European Union’s Horizon 2020 research and innovation program under
the Marie Skłodowska-Curie grant agreement No. 746119. This paper makes use of the
following ALMA data: ADS/JAO.ALMA#2017.1.01451.S. ALMA is a partnership of ESO (representing
its member states), NSF (USA), and NINS (Japan), together with NRC (Canada), NSC
and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic
of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO, and NAOJ. Based
on observations obtained with the Very Large Telescope, programs 294.A-5018, 097.A-0943,
and 99.A-0462. Based on observations made with the NASA/ESA Hubble Space Telescope,
obtained (from the Data Archive) at the Space Telescope Science Institute, which
is operated by the Association of Universities for Research in Astronomy, Inc.,
under NASA contract NAS 5-26555. These observations are associated with program
No. 14699.'
article_number: '124'
article_processing_charge: No
article_type: original
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: D.
full_name: Sobral, D.
last_name: Sobral
- first_name: L. A.
full_name: Boogaard, L. A.
last_name: Boogaard
- first_name: H.
full_name: Röttgering, H.
last_name: Röttgering
- first_name: L.
full_name: Vallini, L.
last_name: Vallini
- first_name: A.
full_name: Ferrara, A.
last_name: Ferrara
- first_name: A.
full_name: Paulino-Afonso, A.
last_name: Paulino-Afonso
- first_name: F.
full_name: Boone, F.
last_name: Boone
- first_name: D.
full_name: Schaerer, D.
last_name: Schaerer
- first_name: B.
full_name: Mobasher, B.
last_name: Mobasher
citation:
ama: Matthee JJ, Sobral D, Boogaard LA, et al. Resolved UV and [C ii] structures
of luminous galaxies within the epoch of reionization. The Astrophysical Journal.
2019;881(2). doi:10.3847/1538-4357/ab2f81
apa: Matthee, J. J., Sobral, D., Boogaard, L. A., Röttgering, H., Vallini, L., Ferrara,
A., … Mobasher, B. (2019). Resolved UV and [C ii] structures of luminous galaxies
within the epoch of reionization. The Astrophysical Journal. IOP Publishing.
https://doi.org/10.3847/1538-4357/ab2f81
chicago: Matthee, Jorryt J, D. Sobral, L. A. Boogaard, H. Röttgering, L. Vallini,
A. Ferrara, A. Paulino-Afonso, F. Boone, D. Schaerer, and B. Mobasher. “Resolved
UV and [C Ii] Structures of Luminous Galaxies within the Epoch of Reionization.”
The Astrophysical Journal. IOP Publishing, 2019. https://doi.org/10.3847/1538-4357/ab2f81.
ieee: J. J. Matthee et al., “Resolved UV and [C ii] structures of luminous
galaxies within the epoch of reionization,” The Astrophysical Journal,
vol. 881, no. 2. IOP Publishing, 2019.
ista: Matthee JJ, Sobral D, Boogaard LA, Röttgering H, Vallini L, Ferrara A, Paulino-Afonso
A, Boone F, Schaerer D, Mobasher B. 2019. Resolved UV and [C ii] structures of
luminous galaxies within the epoch of reionization. The Astrophysical Journal.
881(2), 124.
mla: Matthee, Jorryt J., et al. “Resolved UV and [C Ii] Structures of Luminous Galaxies
within the Epoch of Reionization.” The Astrophysical Journal, vol. 881,
no. 2, 124, IOP Publishing, 2019, doi:10.3847/1538-4357/ab2f81.
short: J.J. Matthee, D. Sobral, L.A. Boogaard, H. Röttgering, L. Vallini, A. Ferrara,
A. Paulino-Afonso, F. Boone, D. Schaerer, B. Mobasher, The Astrophysical Journal
881 (2019).
date_created: 2022-07-06T13:38:15Z
date_published: 2019-08-21T00:00:00Z
date_updated: 2022-08-18T10:19:48Z
day: '21'
doi: 10.3847/1538-4357/ab2f81
extern: '1'
external_id:
arxiv:
- '1903.08171'
intvolume: ' 881'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1903.08171
month: '08'
oa: 1
oa_version: Preprint
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Resolved UV and [C ii] structures of luminous galaxies within the epoch of
reionization
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 881
year: '2019'
...
---
_id: '11517'
abstract:
- lang: eng
text: To understand star formation in galaxies, we investigate the star formation
rate (SFR) surface density (ΣSFR) profiles for galaxies, based on a well-defined
sample of 976 star-forming MaNGA galaxies. We find that the typical ΣSFR profiles
within 1.5Re of normal SF galaxies can be well described by an exponential function
for different stellar mass intervals, while the sSFR profile shows positive gradients,
especially for more massive SF galaxies. This is due to the more pronounced central
cores or bulges rather than the onset of a `quenching' process. While galaxies
that lie significantly above (or below) the star formation main sequence (SFMS)
show overall an elevation (or suppression) of ΣSFR at all radii, this central
elevation (or suppression) is more pronounced in more massive galaxies. The degree
of central enhancement and suppression is quite symmetric, suggesting that both
the elevation and suppression of star formation are following the same physical
processes. Furthermore, we find that the dispersion in ΣSFR within and across
the population is found to be tightly correlated with the inferred gas depletion
time, whether based on the stellar surface mass density or the orbital dynamical
time. This suggests that we are seeing the response of a simple gas-regulator
system to variations in the accretion rate. This is explored using a heuristic
model that can quantitatively explain the dependence of σ(ΣSFR) on gas depletion
timescale. Variations in accretion rate are progressively more damped out in regions
of low star-formation efficiency leading to a reduced amplitude of variations
in star-formation.
acknowledgement: "We are grateful to the anonymous referee for their thoughtful and
constructive review of the paper and their several suggestions (including the analysis
of Section 3.4), which have improved the paper. This research has been supported
by the Swiss National Science Foundation.\r\n\r\nFunding for the Sloan Digital Sky
Survey IV has been provided by the Alfred P. Sloan Foundation, the U.S. Department
of Energy Office of Science, and the Participating Institutions. SDSS-IV acknowledges
support and resources from the Center for High-Performance Computing at the University
of Utah. The SDSS website is www.sdss.org.\r\n\r\nSDSS-IV is managed by the Astrophysical
Research Consortium for the Participating Institutions of the SDSS Collaboration,
including the Brazilian Participation Group, the Carnegie Institution for Science,
Carnegie Mellon University, the Chilean Participation Group, the French Participation
Group, Harvard-Smithsonian Center for Astrophysics, Instituto de Astrofísica de
Canarias, the Johns Hopkins University, Kavli Institute for the Physics and Mathematics
of the Universe (IPMU)/University of Tokyo, Lawrence Berkeley National Laboratory,
Leibniz Institut für Astrophysik Potsdam (AIP), Max-Planck-Institut für Astronomie
(MPIA Heidelberg), Max-Planck-Institut für Astrophysik (MPA Garching), Max-Planck-Institut
für Extraterrestrische Physik (MPE), National Astronomical Observatory of China,
New Mexico State University, New York University, University of Notre Dame, Observatário
Nacional/MCTI, the Ohio State University, Pennsylvania State University, Shanghai
Astronomical Observatory, United Kingdom Participation Group, Universidad Nacional
Autónoma de México, University of Arizona, University of Colorado Boulder, University
of Oxford, University of Portsmouth, University of Utah, University of Virginia,
University of Washington, University of Wisconsin, Vanderbilt University, and Yale
University"
article_number: '132'
article_processing_charge: No
article_type: original
author:
- first_name: Enci
full_name: Wang, Enci
last_name: Wang
- first_name: Simon J.
full_name: Lilly, Simon J.
last_name: Lilly
- first_name: Gabriele
full_name: Pezzulli, Gabriele
last_name: Pezzulli
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: Wang E, Lilly SJ, Pezzulli G, Matthee JJ. On the elevation and suppression
of star formation within galaxies. The Astrophysical Journal. 2019;877(2).
doi:10.3847/1538-4357/ab1c5b
apa: Wang, E., Lilly, S. J., Pezzulli, G., & Matthee, J. J. (2019). On the elevation
and suppression of star formation within galaxies. The Astrophysical Journal.
IOP Publishing. https://doi.org/10.3847/1538-4357/ab1c5b
chicago: Wang, Enci, Simon J. Lilly, Gabriele Pezzulli, and Jorryt J Matthee. “On
the Elevation and Suppression of Star Formation within Galaxies.” The Astrophysical
Journal. IOP Publishing, 2019. https://doi.org/10.3847/1538-4357/ab1c5b.
ieee: E. Wang, S. J. Lilly, G. Pezzulli, and J. J. Matthee, “On the elevation and
suppression of star formation within galaxies,” The Astrophysical Journal,
vol. 877, no. 2. IOP Publishing, 2019.
ista: Wang E, Lilly SJ, Pezzulli G, Matthee JJ. 2019. On the elevation and suppression
of star formation within galaxies. The Astrophysical Journal. 877(2), 132.
mla: Wang, Enci, et al. “On the Elevation and Suppression of Star Formation within
Galaxies.” The Astrophysical Journal, vol. 877, no. 2, 132, IOP Publishing,
2019, doi:10.3847/1538-4357/ab1c5b.
short: E. Wang, S.J. Lilly, G. Pezzulli, J.J. Matthee, The Astrophysical Journal
877 (2019).
date_created: 2022-07-07T08:38:24Z
date_published: 2019-06-04T00:00:00Z
date_updated: 2022-08-18T10:19:08Z
day: '04'
doi: 10.3847/1538-4357/ab1c5b
extern: '1'
external_id:
arxiv:
- '1901.10276'
intvolume: ' 877'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1901.10276
month: '06'
oa: 1
oa_version: Preprint
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the elevation and suppression of star formation within galaxies
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 877
year: '2019'
...
---
_id: '11535'
abstract:
- lang: eng
text: We investigate the clustering and halo properties of ∼5000 Ly α-selected emission-line
galaxies (LAEs) from the Slicing COSMOS 4K (SC4K) and from archival NB497 imaging
of SA22 split in 15 discrete redshift slices between z ∼ 2.5 and 6. We measure
clustering lengths of r0 ∼ 3–6 h−1 Mpc and typical halo masses of ∼1011 M⊙ for
our narrowband-selected LAEs with typical LLy α ∼ 1042–43 erg s−1. The intermediate-band-selected
LAEs are observed to have r0 ∼ 3.5–15 h−1 Mpc with typical halo masses of ∼1011–12
M⊙ and typical LLy α ∼ 1043–43.6 erg s−1. We find a strong, redshift-independent
correlation between halo mass and Ly α luminosity normalized by the characteristic
Ly α luminosity, L⋆(z). The faintest LAEs (L ∼ 0.1 L⋆(z)) typically identified
by deep narrowband surveys are found in 1010 M⊙ haloes and the brightest LAEs
(L ∼ 7 L⋆(z)) are found in ∼5 × 1012 M⊙ haloes. A dependency on the rest-frame
1500 Å UV luminosity, MUV, is also observed where the halo masses increase from
1011 to 1013 M⊙ for MUV ∼ −19 to −23.5 mag. Halo mass is also observed to increase
from 109.8 to 1012 M⊙ for dust-corrected UV star formation rates from ∼0.6 to
10 M⊙ yr−1 and continues to increase up to 1013 M⊙ in halo mass, where the majority
of those sources are active galactic nuclei. All the trends we observe are found
to be redshift independent. Our results reveal that LAEs are the likely progenitors
of a wide range of galaxies depending on their luminosity, from dwarf-like, to
Milky Way-type, to bright cluster galaxies. LAEs therefore provide unique insight
into the early formation and evolution of the galaxies we observe in the local
Universe.
acknowledgement: We thank the anonymous referee for their useful comments and suggestions
that helped improve this study. AAK acknowledges that this work was supported by
NASA Headquarters under the NASA Earth and Space Science Fellowship Program – Grant
NNX16AO92H. JM acknowledges support from the ETH Zwicky fellowship. RKC acknowledges
funding from STFC via a studentship. APA acknowledges support from the Fundac¸ao
para a Ci ˜ encia e a Tecnologia FCT through the fellowship PD/BD/52706/2014 and
the research grant UID/FIS/04434/2013. JC and SS both acknowledge their support
from the Lancaster University PhD Fellowship. We have benefited greatly from the
publicly available programming language PYTHON, including the NUMPY, SCIPY, MATPLOTLIB,
SCIKIT-LEARN, and ASTROPY packages, as well as the TOPCAT analysis program. The
SC4K samples used in this paper are all publicly available for use by the community
(Sobral et al. 2018a). The catalogue is also available on the COSMOS IPAC website
(https://irsa.ipac.caltech.edu/data/COSMOS/overview.html).
article_processing_charge: No
article_type: original
author:
- first_name: A A
full_name: Khostovan, A A
last_name: Khostovan
- first_name: D
full_name: Sobral, D
last_name: Sobral
- first_name: B
full_name: Mobasher, B
last_name: Mobasher
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: R K
full_name: Cochrane, R K
last_name: Cochrane
- first_name: N
full_name: Chartab, N
last_name: Chartab
- first_name: M
full_name: Jafariyazani, M
last_name: Jafariyazani
- first_name: A
full_name: Paulino-Afonso, A
last_name: Paulino-Afonso
- first_name: S
full_name: Santos, S
last_name: Santos
- first_name: J
full_name: Calhau, J
last_name: Calhau
citation:
ama: 'Khostovan AA, Sobral D, Mobasher B, et al. The clustering of typical Ly α emitters
from z ∼ 2.5–6: Host halo masses depend on Ly α and UV luminosities. Monthly
Notices of the Royal Astronomical Society. 2019;489(1):555-573. doi:10.1093/mnras/stz2149'
apa: 'Khostovan, A. A., Sobral, D., Mobasher, B., Matthee, J. J., Cochrane, R. K.,
Chartab, N., … Calhau, J. (2019). The clustering of typical Ly α emitters from
z ∼ 2.5–6: Host halo masses depend on Ly α and UV luminosities. Monthly Notices
of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stz2149'
chicago: 'Khostovan, A A, D Sobral, B Mobasher, Jorryt J Matthee, R K Cochrane,
N Chartab, M Jafariyazani, A Paulino-Afonso, S Santos, and J Calhau. “The Clustering
of Typical Ly α Emitters from z ∼ 2.5–6: Host Halo Masses Depend on Ly α and UV
Luminosities.” Monthly Notices of the Royal Astronomical Society. Oxford
University Press, 2019. https://doi.org/10.1093/mnras/stz2149.'
ieee: 'A. A. Khostovan et al., “The clustering of typical Ly α emitters from
z ∼ 2.5–6: Host halo masses depend on Ly α and UV luminosities,” Monthly Notices
of the Royal Astronomical Society, vol. 489, no. 1. Oxford University Press,
pp. 555–573, 2019.'
ista: 'Khostovan AA, Sobral D, Mobasher B, Matthee JJ, Cochrane RK, Chartab N, Jafariyazani
M, Paulino-Afonso A, Santos S, Calhau J. 2019. The clustering of typical Ly α emitters
from z ∼ 2.5–6: Host halo masses depend on Ly α and UV luminosities. Monthly Notices
of the Royal Astronomical Society. 489(1), 555–573.'
mla: 'Khostovan, A. A., et al. “The Clustering of Typical Ly α Emitters from z ∼
2.5–6: Host Halo Masses Depend on Ly α and UV Luminosities.” Monthly Notices
of the Royal Astronomical Society, vol. 489, no. 1, Oxford University Press,
2019, pp. 555–73, doi:10.1093/mnras/stz2149.'
short: A.A. Khostovan, D. Sobral, B. Mobasher, J.J. Matthee, R.K. Cochrane, N. Chartab,
M. Jafariyazani, A. Paulino-Afonso, S. Santos, J. Calhau, Monthly Notices of the
Royal Astronomical Society 489 (2019) 555–573.
date_created: 2022-07-07T13:01:03Z
date_published: 2019-10-01T00:00:00Z
date_updated: 2022-08-19T06:38:42Z
day: '01'
doi: 10.1093/mnras/stz2149
extern: '1'
external_id:
arxiv:
- '1811.00556'
intvolume: ' 489'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: haloes'
- 'galaxies: high-redshift'
- 'galaxies: star formation'
- 'cosmology: observations'
- large-scale structure of Universe
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1811.00556
month: '10'
oa: 1
oa_version: Preprint
page: 555-573
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The clustering of typical Ly α emitters from z ∼ 2.5–6: Host halo masses depend
on Ly α and UV luminosities'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 489
year: '2019'
...
---
_id: '11541'
abstract:
- lang: eng
text: We present new Hubble Space Telescope (HST)/WFC3 observations and re-analyse
VLT data to unveil the continuum, variability, and rest-frame ultraviolet (UV)
lines of the multiple UV clumps of the most luminous Lyα emitter at z = 6.6, CR7
(COSMOS Redshift 7). Our re-reduced, flux-calibrated X-SHOOTER spectra of CR7
reveal an He II emission line in observations obtained along the major axis of
Lyα emission with the best seeing conditions. He II is spatially offset by ≈+0.8
arcsec from the peak of Lyα emission, and it is found towards clump B. Our WFC3
grism spectra detects the UV continuum of CR7’s clump A, yielding a power law
with β=−2.5+0.6−0.7 and MUV=−21.87+0.25−0.20. No significant variability is found
for any of the UV clumps on their own, but there is tentative (≈2.2 σ) brightening
of CR7 in F110W as a whole from 2012 to 2017. HST grism data fail to robustly
detect rest-frame UV lines in any of the clumps, implying fluxes ≲2×10−17 erg s−1 cm−2
(3σ). We perform CLOUDY modelling to constrain the metallicity and the ionizing
nature of CR7. CR7 seems to be actively forming stars without any clear active
galactic nucleus activity in clump A, consistent with a metallicity of ∼0.05–0.2 Z⊙.
Component C or an interclump component between B and C may host a high ionization
source. Our results highlight the need for spatially resolved information to study
the formation and assembly of early galaxies.
acknowledgement: We thank the anonymous reviewer for the numerous detailed comments
that led us to greatly improve the quality, extent, and statistical robustness of
this work. DS acknowledges financial support from the Netherlands Organisation for
Scientific research through a Veni fellowship. JM acknowledges the support of a
Huygens PhD fellowship from Leiden University. AF acknowledges support from the
ERC Advanced Grant INTERSTELLAR H2020/740120. BD acknowledges financial support
from NASA through the Astrophysics Data Analysis Program, grant number NNX12AE20G
and the National Science Foundation, grant number 1716907. We are thankful for several
discussions and constructive comments from Johannes Zabl, Eros Vanzella, Bo Milvang-Jensen,
Henry McCracken, Max Gronke, Mark Dijkstra, Richard Ellis, and Nicolas Laporte.
We also thank Umar Burhanudin and Izzy Garland for taking part in the XGAL internship
in Lancaster and for exploring the HST grism data independently. Based on observations
obtained with HST/WFC3 programs 12578, 14495, and 14596. Based on observations of
the National Japanese Observatory with the Suprime-Cam on the Subaru telescope (S14A-086)
on the big island of Hawaii. This work is based in part on data products produced
at TERAPIX available at the Canadian Astronomy Data Centre as part of the Canada–France–Hawaii
Telescope Legacy Survey, a collaborative project of NRC and CNRS. Based on data
products from observations made with ESO Telescopes at the La Silla Paranal Observatory
under ESO programme IDs 294.A-5018, 294.A-5039, 092.A 0786, 093.A-0561, 097.A0043,
097.A-0943, 098.A-0819, 298.A-5012, and 179.A-2005, and on data products produced
by TERAPIX and the Cambridge Astronomy Survey Unit on behalf of the UltraVISTA consortium.
The authors acknowledge the award of service time (SW2014b20) on the William Herschel
Telescope (WHT). WHT and its service programme are operated on the island of La
Palma by the Isaac Newton Group in the Spanish Observatorio del Roque de los Muchachos
of the Instituto de Astrofisica de Canarias. This research was supported by the
Munich Institute for Astro- and Particle Physics of the DFG cluster of excellence
‘Origin and Structure of the Universe’. We have benefitted immensely from the public
available programming language PYTHON, including NUMPY and SCIPY (Jones et al. 2001;
Van Der Walt, Colbert & Varoquaux 2011), MATPLOTLIB (Hunter 2007), ASTROPY (Astropy
Collaboration et al. 2013), and the TOPCAT analysis program (Taylor 2013). This
research has made use of the VizieR catalogue access tool, CDS, Strasbourg, France.
All data used for this paper are publicly available, and we make all reduced data
available with the refereed paper.
article_processing_charge: No
article_type: original
author:
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Gabriel
full_name: Brammer, Gabriel
last_name: Brammer
- first_name: Andrea
full_name: Ferrara, Andrea
last_name: Ferrara
- first_name: Lara
full_name: Alegre, Lara
last_name: Alegre
- first_name: Huub
full_name: Röttgering, Huub
last_name: Röttgering
- first_name: Daniel
full_name: Schaerer, Daniel
last_name: Schaerer
- first_name: Bahram
full_name: Mobasher, Bahram
last_name: Mobasher
- first_name: Behnam
full_name: Darvish, Behnam
last_name: Darvish
citation:
ama: Sobral D, Matthee JJ, Brammer G, et al. On the nature and physical conditions
of the luminous Ly α emitter CR7 and its rest-frame UV components. Monthly
Notices of the Royal Astronomical Society. 2019;482(2):2422-2441. doi:10.1093/mnras/sty2779
apa: Sobral, D., Matthee, J. J., Brammer, G., Ferrara, A., Alegre, L., Röttgering,
H., … Darvish, B. (2019). On the nature and physical conditions of the luminous
Ly α emitter CR7 and its rest-frame UV components. Monthly Notices of the Royal
Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/sty2779
chicago: Sobral, David, Jorryt J Matthee, Gabriel Brammer, Andrea Ferrara, Lara
Alegre, Huub Röttgering, Daniel Schaerer, Bahram Mobasher, and Behnam Darvish.
“On the Nature and Physical Conditions of the Luminous Ly α Emitter CR7 and Its
Rest-Frame UV Components.” Monthly Notices of the Royal Astronomical Society.
Oxford University Press, 2019. https://doi.org/10.1093/mnras/sty2779.
ieee: D. Sobral et al., “On the nature and physical conditions of the luminous
Ly α emitter CR7 and its rest-frame UV components,” Monthly Notices of the
Royal Astronomical Society, vol. 482, no. 2. Oxford University Press, pp.
2422–2441, 2019.
ista: Sobral D, Matthee JJ, Brammer G, Ferrara A, Alegre L, Röttgering H, Schaerer
D, Mobasher B, Darvish B. 2019. On the nature and physical conditions of the luminous
Ly α emitter CR7 and its rest-frame UV components. Monthly Notices of the Royal
Astronomical Society. 482(2), 2422–2441.
mla: Sobral, David, et al. “On the Nature and Physical Conditions of the Luminous
Ly α Emitter CR7 and Its Rest-Frame UV Components.” Monthly Notices of the
Royal Astronomical Society, vol. 482, no. 2, Oxford University Press, 2019,
pp. 2422–41, doi:10.1093/mnras/sty2779.
short: D. Sobral, J.J. Matthee, G. Brammer, A. Ferrara, L. Alegre, H. Röttgering,
D. Schaerer, B. Mobasher, B. Darvish, Monthly Notices of the Royal Astronomical
Society 482 (2019) 2422–2441.
date_created: 2022-07-08T10:40:05Z
date_published: 2019-01-01T00:00:00Z
date_updated: 2022-08-19T06:49:36Z
day: '01'
doi: 10.1093/mnras/sty2779
extern: '1'
external_id:
arxiv:
- '1710.08422'
intvolume: ' 482'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: high-redshift'
- 'galaxies: ISM'
- 'cosmology: observations'
- dark ages
- reionization
- first stars
- early Universe
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1710.08422
month: '01'
oa: 1
oa_version: Preprint
page: 2422-2441
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the nature and physical conditions of the luminous Ly α emitter CR7 and
its rest-frame UV components
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 482
year: '2019'
...
---
_id: '11540'
abstract:
- lang: eng
text: Observations have revealed that the star formation rate (SFR) and stellar
mass (Mstar) of star-forming galaxies follow a tight relation known as the galaxy
main sequence. However, what physical information is encoded in this relation
is under debate. Here, we use the EAGLE cosmological hydrodynamical simulation
to study the mass dependence, evolution, and origin of scatter in the SFR–Mstar
relation. At z = 0, we find that the scatter decreases slightly with stellar mass
from 0.35 dex at Mstar ≈ 109 M⊙ to 0.30 dex at Mstar ≳ 1010.5 M⊙. The scatter
decreases from z = 0 to z = 5 by 0.05 dex at Mstar ≳ 1010 M⊙ and by 0.15 dex for
lower masses. We show that the scatter at z = 0.1 originates from a combination
of fluctuations on short time-scales (ranging from 0.2–2 Gyr) that are presumably
associated with self-regulation from cooling, star formation, and outflows, but
is dominated by long time-scale (∼10 Gyr) variations related to differences in
halo formation times. Shorter time-scale fluctuations are relatively more important
for lower mass galaxies. At high masses, differences in black hole formation efficiency
cause additional scatter, but also diminish the scatter caused by different halo
formation times. While individual galaxies cross the main sequence multiple times
during their evolution, they fluctuate around tracks associated with their halo
properties, i.e. galaxies above/below the main sequence at z = 0.1 tend to have
been above/below the main sequence for ≫1 Gyr.
acknowledgement: JM acknowledges the support of a Huygens PhD fellowship from Leiden
University. We thank Camila Correa for help analysing snipshot merger trees. We
thank the anonymous referee for constructive comments. We also thank Jarle Brinchmann,
Rob Crain, Antonios Katsianis, Paola Popesso, and David Sobral for discussions and
suggestions. We also thank the participants of the Lorentz Center workshop ‘A Decade
of the Star-Forming Main Sequence’ held on 2017 September 4–8, for discussions and
ideas. We have benefited from the public available programming language PYTHON,
including the NUMPY, MATPLOTLIB, and SCIPY (Hunter 2007) packages and the TOPCAT
analysis tool (Taylor 2013).
article_processing_charge: No
article_type: original
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Joop
full_name: Schaye, Joop
last_name: Schaye
citation:
ama: Matthee JJ, Schaye J. The origin of scatter in the star formation rate–stellar
mass relation. Monthly Notices of the Royal Astronomical Society. 2019;484(1):915-932.
doi:10.1093/mnras/stz030
apa: Matthee, J. J., & Schaye, J. (2019). The origin of scatter in the star
formation rate–stellar mass relation. Monthly Notices of the Royal Astronomical
Society. Oxford University Press. https://doi.org/10.1093/mnras/stz030
chicago: Matthee, Jorryt J, and Joop Schaye. “The Origin of Scatter in the Star
Formation Rate–Stellar Mass Relation.” Monthly Notices of the Royal Astronomical
Society. Oxford University Press, 2019. https://doi.org/10.1093/mnras/stz030.
ieee: J. J. Matthee and J. Schaye, “The origin of scatter in the star formation
rate–stellar mass relation,” Monthly Notices of the Royal Astronomical Society,
vol. 484, no. 1. Oxford University Press, pp. 915–932, 2019.
ista: Matthee JJ, Schaye J. 2019. The origin of scatter in the star formation rate–stellar
mass relation. Monthly Notices of the Royal Astronomical Society. 484(1), 915–932.
mla: Matthee, Jorryt J., and Joop Schaye. “The Origin of Scatter in the Star Formation
Rate–Stellar Mass Relation.” Monthly Notices of the Royal Astronomical Society,
vol. 484, no. 1, Oxford University Press, 2019, pp. 915–32, doi:10.1093/mnras/stz030.
short: J.J. Matthee, J. Schaye, Monthly Notices of the Royal Astronomical Society
484 (2019) 915–932.
date_created: 2022-07-08T07:48:31Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2022-08-19T06:42:43Z
day: '01'
doi: 10.1093/mnras/stz030
extern: '1'
external_id:
arxiv:
- '1805.05956'
intvolume: ' 484'
issue: '1'
keyword:
- Space and Planetary Science
- 'Astronomy and Astrophysics : galaxies: evolution'
- 'galaxies: formation'
- 'galaxies: star formation'
- 'cosmology: theory'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1805.05956
month: '03'
oa: 1
oa_version: Preprint
page: 915-932
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: The origin of scatter in the star formation rate–stellar mass relation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 484
year: '2019'
...
---
_id: '11616'
abstract:
- lang: eng
text: We present the discovery of HD 221416 b, the first transiting planet identified
by the Transiting Exoplanet Survey Satellite (TESS) for which asteroseismology
of the host star is possible. HD 221416 b (HIP 116158, TOI-197) is a bright (V
= 8.2 mag), spectroscopically classified subgiant that oscillates with an average
frequency of about 430 μHz and displays a clear signature of mixed modes. The
oscillation amplitude confirms that the redder TESS bandpass compared to Kepler
has a small effect on the oscillations, supporting the expected yield of thousands
of solar-like oscillators with TESS 2 minute cadence observations. Asteroseismic
modeling yields a robust determination of the host star radius (R⋆ = 2.943 ± 0.064
R⊙), mass (M⋆ = 1.212 ± 0.074 M⊙), and age (4.9 ± 1.1 Gyr), and demonstrates that
it has just started ascending the red-giant branch. Combining asteroseismology
with transit modeling and radial-velocity observations, we show that the planet
is a "hot Saturn" (Rp = 9.17 ± 0.33 R⊕) with an orbital period of ∼14.3 days,
irradiance of F = 343 ± 24 F⊕, and moderate mass (Mp = 60.5 ± 5.7 M⊕) and density
(ρp = 0.431 ± 0.062 g cm−3). The properties of HD 221416 b show that the host-star
metallicity–planet mass correlation found in sub-Saturns (4–8 R⊕) does not extend
to larger radii, indicating that planets in the transition between sub-Saturns
and Jupiters follow a relatively narrow range of densities. With a density measured
to ∼15%, HD 221416 b is one of the best characterized Saturn-size planets to date,
augmenting the small number of known transiting planets around evolved stars and
demonstrating the power of TESS to characterize exoplanets and their host stars
using asteroseismology.
acknowledgement: "The authors wish to recognize and acknowledge the very significant
cultural role and reverence that the summit of Maunakea has always had within the
indigenous Hawai'ian community. We are most fortunate to have the opportunity to
conduct observations from this mountain. We thank Andrei Tokovinin for helpful information
on the Speckle observations obtained with SOAR. D.H. acknowledges support by the
National Aeronautics and Space Administration through the TESS Guest Investigator
Program (80NSSC18K1585) and by the National Science Foundation (AST-1717000). A.C.
acknowledges support by the National Science Foundation under the Graduate Research
Fellowship Program. W.J.C., W.H.B., A.M., O.J.H., and G.R.D. acknowledge support
from the Science and Technology Facilities Council and UK Space Agency. H.K. and
F.G. acknowledge support from the European Social Fund via the Lithuanian Science
Council grant No. 09.3.3-LMT-K-712-01-0103. Funding for the Stellar Astrophysics
Centre is provided by The Danish National Research Foundation (grant DNRF106). A.J.
acknowledges support from FONDECYT project 1171208, CONICYT project BASAL AFB-170002,
and by the Ministry for the Economy, Development, and Tourism's Programa Iniciativa
Científica Milenio through grant IC 120009, awarded to the Millennium Institute
of Astrophysics (MAS). R.B. acknowledges support from FONDECYT Post-doctoral Fellowship
Project 3180246, and from the Millennium Institute of Astrophysics (MAS). A.M.S.
is supported by grants ESP2017-82674-R (MINECO) and SGR2017-1131 (AGAUR). R.A.G.
and L.B. acknowledge the support of the PLATO grant from the CNES. The research
leading to the presented results has received funding from the European Research
Council under the European Community's Seventh Framework Programme (FP72007-2013)ERC
grant agreement No. 338251 (StellarAges). S.M. acknowledges support from the European
Research Council through the SPIRE grant 647383. This work was also supported by
FCT (Portugal) through national funds and by FEDER through COMPETE2020 by these
grants: UID/FIS/04434/2013 and POCI-01-0145-FEDER-007672, PTDC/FIS-AST/30389/2017,
and POCI-01-0145-FEDER-030389. T.L.C. acknowledges support from the European Union's
Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
grant agreement No. 792848 (PULSATION). E.C. is funded by the European Union's Horizon
2020 research and innovation program under the Marie Sklodowska-Curie grant agreement
No. 664931. V.S.A. acknowledges support from the Independent Research Fund Denmark
(Research grant 7027-00096B). D.S. acknowledges support from the Australian Research
Council. S.B. acknowledges NASA grant NNX16AI09G and NSF grant AST-1514676. T.R.W.
acknowledges support from the Australian Research Council through grant DP150100250.
A.M. acknowledges support from the ERC Consolidator Grant funding scheme (project
ASTEROCHRONOMETRY, G.A. n. 772293). S.M. acknowledges support from the Ramon y Cajal
fellowship number RYC-2015-17697. M.S.L. is supported by the Carlsberg Foundation
(grant agreement No. CF17-0760). A.M. and P.R. acknowledge support from the HBCSE-NIUS
programme. J.K.T. and J.T. acknowledge that support for this work was provided by
NASA through Hubble Fellowship grants HST-HF2-51399.001 and HST-HF2-51424.001 awarded
by the Space Telescope Science Institute, which is operated by the Association of
Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555.
T.S.R. acknowledges financial support from Premiale 2015 MITiC (PI B. Garilli).
This project has been supported by the NKFIH K-115709 grant and the Lendület Program
of the Hungarian Academy of Sciences, project No. LP2018-7/2018.\r\n\r\nBased on
observations made with the Hertzsprung SONG telescope operated on the Spanish Observatorio
del Teide on the island of Tenerife by the Aarhus and Copenhagen Universities and
by the Instituto de Astrofísica de Canarias. Funding for the TESS mission is provided
by NASA's Science Mission directorate. We acknowledge the use of public TESS Alert
data from pipelines at the TESS Science Office and at the TESS Science Processing
Operations Center. This research has made use of the Exoplanet Follow-up Observation
Program website, which is operated by the California Institute of Technology, under
contract with the National Aeronautics and Space Administration under the Exoplanet
Exploration Program. This paper includes data collected by the TESS mission, which
are publicly available from the Mikulski Archive for Space Telescopes (MAST).\r\n\r\nSoftware:
Astropy (Astropy Collaboration et al. 2018), Matplotlib (Hunter 2007), DIAMONDS
(Corsaro & De Ridder 2014), isoclassify (Huber et al. 2017), EXOFASTv2 (Eastman
2017), ktransit (Barclay 2018)."
article_number: '245'
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
full_name: Huber, Daniel
last_name: Huber
- first_name: William J.
full_name: Chaplin, William J.
last_name: Chaplin
- first_name: Ashley
full_name: Chontos, Ashley
last_name: Chontos
- first_name: Hans
full_name: Kjeldsen, Hans
last_name: Kjeldsen
- first_name: Jørgen
full_name: Christensen-Dalsgaard, Jørgen
last_name: Christensen-Dalsgaard
- first_name: Timothy R.
full_name: Bedding, Timothy R.
last_name: Bedding
- first_name: Warrick
full_name: Ball, Warrick
last_name: Ball
- first_name: Rafael
full_name: Brahm, Rafael
last_name: Brahm
- first_name: Nestor
full_name: Espinoza, Nestor
last_name: Espinoza
- first_name: Thomas
full_name: Henning, Thomas
last_name: Henning
- first_name: Andrés
full_name: Jordán, Andrés
last_name: Jordán
- first_name: Paula
full_name: Sarkis, Paula
last_name: Sarkis
- first_name: Emil
full_name: Knudstrup, Emil
last_name: Knudstrup
- first_name: Simon
full_name: Albrecht, Simon
last_name: Albrecht
- first_name: Frank
full_name: Grundahl, Frank
last_name: Grundahl
- first_name: Mads Fredslund
full_name: Andersen, Mads Fredslund
last_name: Andersen
- first_name: Pere L.
full_name: Pallé, Pere L.
last_name: Pallé
- first_name: Ian
full_name: Crossfield, Ian
last_name: Crossfield
- first_name: Benjamin
full_name: Fulton, Benjamin
last_name: Fulton
- first_name: Andrew W.
full_name: Howard, Andrew W.
last_name: Howard
- first_name: Howard T.
full_name: Isaacson, Howard T.
last_name: Isaacson
- first_name: Lauren M.
full_name: Weiss, Lauren M.
last_name: Weiss
- first_name: Rasmus
full_name: Handberg, Rasmus
last_name: Handberg
- first_name: Mikkel N.
full_name: Lund, Mikkel N.
last_name: Lund
- first_name: Aldo M.
full_name: Serenelli, Aldo M.
last_name: Serenelli
- first_name: Jakob
full_name: Rørsted Mosumgaard, Jakob
last_name: Rørsted Mosumgaard
- first_name: Amalie
full_name: Stokholm, Amalie
last_name: Stokholm
- first_name: Allyson
full_name: Bieryla, Allyson
last_name: Bieryla
- first_name: Lars A.
full_name: Buchhave, Lars A.
last_name: Buchhave
- first_name: David W.
full_name: Latham, David W.
last_name: Latham
- first_name: Samuel N.
full_name: Quinn, Samuel N.
last_name: Quinn
- first_name: Eric
full_name: Gaidos, Eric
last_name: Gaidos
- first_name: Teruyuki
full_name: Hirano, Teruyuki
last_name: Hirano
- first_name: George R.
full_name: Ricker, George R.
last_name: Ricker
- first_name: Roland K.
full_name: Vanderspek, Roland K.
last_name: Vanderspek
- first_name: Sara
full_name: Seager, Sara
last_name: Seager
- first_name: Jon M.
full_name: Jenkins, Jon M.
last_name: Jenkins
- first_name: Joshua N.
full_name: Winn, Joshua N.
last_name: Winn
- first_name: H. M.
full_name: Antia, H. M.
last_name: Antia
- first_name: Thierry
full_name: Appourchaux, Thierry
last_name: Appourchaux
- first_name: Sarbani
full_name: Basu, Sarbani
last_name: Basu
- first_name: Keaton J.
full_name: Bell, Keaton J.
last_name: Bell
- first_name: Othman
full_name: Benomar, Othman
last_name: Benomar
- first_name: Alfio
full_name: Bonanno, Alfio
last_name: Bonanno
- first_name: Derek L.
full_name: Buzasi, Derek L.
last_name: Buzasi
- first_name: Tiago L.
full_name: Campante, Tiago L.
last_name: Campante
- first_name: Z.
full_name: Çelik Orhan, Z.
last_name: Çelik Orhan
- first_name: Enrico
full_name: Corsaro, Enrico
last_name: Corsaro
- first_name: Margarida S.
full_name: Cunha, Margarida S.
last_name: Cunha
- first_name: Guy R.
full_name: Davies, Guy R.
last_name: Davies
- first_name: Sebastien
full_name: Deheuvels, Sebastien
last_name: Deheuvels
- first_name: Samuel K.
full_name: Grunblatt, Samuel K.
last_name: Grunblatt
- first_name: Amir
full_name: Hasanzadeh, Amir
last_name: Hasanzadeh
- first_name: Maria Pia
full_name: Di Mauro, Maria Pia
last_name: Di Mauro
- first_name: Rafael
full_name: A. García, Rafael
last_name: A. García
- first_name: Patrick
full_name: Gaulme, Patrick
last_name: Gaulme
- first_name: Léo
full_name: Girardi, Léo
last_name: Girardi
- first_name: Joyce A.
full_name: Guzik, Joyce A.
last_name: Guzik
- first_name: Marc
full_name: Hon, Marc
last_name: Hon
- first_name: Chen
full_name: Jiang, Chen
last_name: Jiang
- first_name: Thomas
full_name: Kallinger, Thomas
last_name: Kallinger
- first_name: Steven D.
full_name: Kawaler, Steven D.
last_name: Kawaler
- first_name: James S.
full_name: Kuszlewicz, James S.
last_name: Kuszlewicz
- first_name: Yveline
full_name: Lebreton, Yveline
last_name: Lebreton
- first_name: Tanda
full_name: Li, Tanda
last_name: Li
- first_name: Miles
full_name: Lucas, Miles
last_name: Lucas
- first_name: Mia S.
full_name: Lundkvist, Mia S.
last_name: Lundkvist
- first_name: Andrew W.
full_name: Mann, Andrew W.
last_name: Mann
- first_name: Stéphane
full_name: Mathis, Stéphane
last_name: Mathis
- first_name: Savita
full_name: Mathur, Savita
last_name: Mathur
- first_name: Anwesh
full_name: Mazumdar, Anwesh
last_name: Mazumdar
- first_name: Travis S.
full_name: Metcalfe, Travis S.
last_name: Metcalfe
- first_name: Andrea
full_name: Miglio, Andrea
last_name: Miglio
- first_name: Mário J. P.
full_name: F. G. Monteiro, Mário J. P.
last_name: F. G. Monteiro
- first_name: Benoit
full_name: Mosser, Benoit
last_name: Mosser
- first_name: Anthony
full_name: Noll, Anthony
last_name: Noll
- first_name: Benard
full_name: Nsamba, Benard
last_name: Nsamba
- first_name: Jia Mian
full_name: Joel Ong, Jia Mian
last_name: Joel Ong
- first_name: S.
full_name: Örtel, S.
last_name: Örtel
- first_name: Filipe
full_name: Pereira, Filipe
last_name: Pereira
- first_name: Pritesh
full_name: Ranadive, Pritesh
last_name: Ranadive
- first_name: Clara
full_name: Régulo, Clara
last_name: Régulo
- first_name: Thaíse S.
full_name: Rodrigues, Thaíse S.
last_name: Rodrigues
- first_name: Ian W.
full_name: Roxburgh, Ian W.
last_name: Roxburgh
- first_name: Victor Silva
full_name: Aguirre, Victor Silva
last_name: Aguirre
- first_name: Barry
full_name: Smalley, Barry
last_name: Smalley
- first_name: Mathew
full_name: Schofield, Mathew
last_name: Schofield
- first_name: Sérgio G.
full_name: Sousa, Sérgio G.
last_name: Sousa
- first_name: Keivan G.
full_name: Stassun, Keivan G.
last_name: Stassun
- first_name: Dennis
full_name: Stello, Dennis
last_name: Stello
- first_name: Jamie
full_name: Tayar, Jamie
last_name: Tayar
- first_name: Timothy R.
full_name: White, Timothy R.
last_name: White
- first_name: Kuldeep
full_name: Verma, Kuldeep
last_name: Verma
- first_name: Mathieu
full_name: Vrard, Mathieu
last_name: Vrard
- first_name: M.
full_name: Yıldız, M.
last_name: Yıldız
- first_name: David
full_name: Baker, David
last_name: Baker
- first_name: Michaël
full_name: Bazot, Michaël
last_name: Bazot
- first_name: Charles
full_name: Beichmann, Charles
last_name: Beichmann
- first_name: Christoph
full_name: Bergmann, Christoph
last_name: Bergmann
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: Bryson
full_name: Cale, Bryson
last_name: Cale
- first_name: Roberto
full_name: Carlino, Roberto
last_name: Carlino
- first_name: Scott M.
full_name: Cartwright, Scott M.
last_name: Cartwright
- first_name: Jessie L.
full_name: Christiansen, Jessie L.
last_name: Christiansen
- first_name: David R.
full_name: Ciardi, David R.
last_name: Ciardi
- first_name: Orlagh
full_name: Creevey, Orlagh
last_name: Creevey
- first_name: Jason A.
full_name: Dittmann, Jason A.
last_name: Dittmann
- first_name: Jose-Dias Do
full_name: Nascimento, Jose-Dias Do
last_name: Nascimento
- first_name: Vincent Van
full_name: Eylen, Vincent Van
last_name: Eylen
- first_name: Gabor
full_name: Fürész, Gabor
last_name: Fürész
- first_name: Jonathan
full_name: Gagné, Jonathan
last_name: Gagné
- first_name: Peter
full_name: Gao, Peter
last_name: Gao
- first_name: Kosmas
full_name: Gazeas, Kosmas
last_name: Gazeas
- first_name: Frank
full_name: Giddens, Frank
last_name: Giddens
- first_name: Oliver J.
full_name: Hall, Oliver J.
last_name: Hall
- first_name: Saskia
full_name: Hekker, Saskia
last_name: Hekker
- first_name: Michael J.
full_name: Ireland, Michael J.
last_name: Ireland
- first_name: Natasha
full_name: Latouf, Natasha
last_name: Latouf
- first_name: Danny
full_name: LeBrun, Danny
last_name: LeBrun
- first_name: Alan M.
full_name: Levine, Alan M.
last_name: Levine
- first_name: William
full_name: Matzko, William
last_name: Matzko
- first_name: Eva
full_name: Natinsky, Eva
last_name: Natinsky
- first_name: Emma
full_name: Page, Emma
last_name: Page
- first_name: Peter
full_name: Plavchan, Peter
last_name: Plavchan
- first_name: Masoud
full_name: Mansouri-Samani, Masoud
last_name: Mansouri-Samani
- first_name: Sean
full_name: McCauliff, Sean
last_name: McCauliff
- first_name: Susan E.
full_name: Mullally, Susan E.
last_name: Mullally
- first_name: Brendan
full_name: Orenstein, Brendan
last_name: Orenstein
- first_name: Aylin Garcia
full_name: Soto, Aylin Garcia
last_name: Soto
- first_name: Martin
full_name: Paegert, Martin
last_name: Paegert
- first_name: Jennifer L.
full_name: van Saders, Jennifer L.
last_name: van Saders
- first_name: Chloe
full_name: Schnaible, Chloe
last_name: Schnaible
- first_name: David R.
full_name: Soderblom, David R.
last_name: Soderblom
- first_name: Róbert
full_name: Szabó, Róbert
last_name: Szabó
- first_name: Angelle
full_name: Tanner, Angelle
last_name: Tanner
- first_name: C. G.
full_name: Tinney, C. G.
last_name: Tinney
- first_name: Johanna
full_name: Teske, Johanna
last_name: Teske
- first_name: Alexandra
full_name: Thomas, Alexandra
last_name: Thomas
- first_name: Regner
full_name: Trampedach, Regner
last_name: Trampedach
- first_name: Duncan
full_name: Wright, Duncan
last_name: Wright
- first_name: Thomas T.
full_name: Yuan, Thomas T.
last_name: Yuan
- first_name: Farzaneh
full_name: Zohrabi, Farzaneh
last_name: Zohrabi
citation:
ama: Huber D, Chaplin WJ, Chontos A, et al. A hot Saturn orbiting an oscillating
late subgiant discovered by TESS. The Astronomical Journal. 2019;157(6).
doi:10.3847/1538-3881/ab1488
apa: Huber, D., Chaplin, W. J., Chontos, A., Kjeldsen, H., Christensen-Dalsgaard,
J., Bedding, T. R., … Zohrabi, F. (2019). A hot Saturn orbiting an oscillating
late subgiant discovered by TESS. The Astronomical Journal. IOP Publishing.
https://doi.org/10.3847/1538-3881/ab1488
chicago: Huber, Daniel, William J. Chaplin, Ashley Chontos, Hans Kjeldsen, Jørgen
Christensen-Dalsgaard, Timothy R. Bedding, Warrick Ball, et al. “A Hot Saturn
Orbiting an Oscillating Late Subgiant Discovered by TESS.” The Astronomical
Journal. IOP Publishing, 2019. https://doi.org/10.3847/1538-3881/ab1488.
ieee: D. Huber et al., “A hot Saturn orbiting an oscillating late subgiant
discovered by TESS,” The Astronomical Journal, vol. 157, no. 6. IOP Publishing,
2019.
ista: Huber D et al. 2019. A hot Saturn orbiting an oscillating late subgiant discovered
by TESS. The Astronomical Journal. 157(6), 245.
mla: Huber, Daniel, et al. “A Hot Saturn Orbiting an Oscillating Late Subgiant Discovered
by TESS.” The Astronomical Journal, vol. 157, no. 6, 245, IOP Publishing,
2019, doi:10.3847/1538-3881/ab1488.
short: D. Huber, W.J. Chaplin, A. Chontos, H. Kjeldsen, J. Christensen-Dalsgaard,
T.R. Bedding, W. Ball, R. Brahm, N. Espinoza, T. Henning, A. Jordán, P. Sarkis,
E. Knudstrup, S. Albrecht, F. Grundahl, M.F. Andersen, P.L. Pallé, I. Crossfield,
B. Fulton, A.W. Howard, H.T. Isaacson, L.M. Weiss, R. Handberg, M.N. Lund, A.M.
Serenelli, J. Rørsted Mosumgaard, A. Stokholm, A. Bieryla, L.A. Buchhave, D.W.
Latham, S.N. Quinn, E. Gaidos, T. Hirano, G.R. Ricker, R.K. Vanderspek, S. Seager,
J.M. Jenkins, J.N. Winn, H.M. Antia, T. Appourchaux, S. Basu, K.J. Bell, O. Benomar,
A. Bonanno, D.L. Buzasi, T.L. Campante, Z. Çelik Orhan, E. Corsaro, M.S. Cunha,
G.R. Davies, S. Deheuvels, S.K. Grunblatt, A. Hasanzadeh, M.P. Di Mauro, R. A.
García, P. Gaulme, L. Girardi, J.A. Guzik, M. Hon, C. Jiang, T. Kallinger, S.D.
Kawaler, J.S. Kuszlewicz, Y. Lebreton, T. Li, M. Lucas, M.S. Lundkvist, A.W. Mann,
S. Mathis, S. Mathur, A. Mazumdar, T.S. Metcalfe, A. Miglio, M.J.P. F. G. Monteiro,
B. Mosser, A. Noll, B. Nsamba, J.M. Joel Ong, S. Örtel, F. Pereira, P. Ranadive,
C. Régulo, T.S. Rodrigues, I.W. Roxburgh, V.S. Aguirre, B. Smalley, M. Schofield,
S.G. Sousa, K.G. Stassun, D. Stello, J. Tayar, T.R. White, K. Verma, M. Vrard,
M. Yıldız, D. Baker, M. Bazot, C. Beichmann, C. Bergmann, L.A. Bugnet, B. Cale,
R. Carlino, S.M. Cartwright, J.L. Christiansen, D.R. Ciardi, O. Creevey, J.A.
Dittmann, J.-D.D. Nascimento, V.V. Eylen, G. Fürész, J. Gagné, P. Gao, K. Gazeas,
F. Giddens, O.J. Hall, S. Hekker, M.J. Ireland, N. Latouf, D. LeBrun, A.M. Levine,
W. Matzko, E. Natinsky, E. Page, P. Plavchan, M. Mansouri-Samani, S. McCauliff,
S.E. Mullally, B. Orenstein, A.G. Soto, M. Paegert, J.L. van Saders, C. Schnaible,
D.R. Soderblom, R. Szabó, A. Tanner, C.G. Tinney, J. Teske, A. Thomas, R. Trampedach,
D. Wright, T.T. Yuan, F. Zohrabi, The Astronomical Journal 157 (2019).
date_created: 2022-07-18T14:29:07Z
date_published: 2019-05-30T00:00:00Z
date_updated: 2022-08-22T07:38:34Z
day: '30'
doi: 10.3847/1538-3881/ab1488
extern: '1'
external_id:
arxiv:
- '1901.01643'
intvolume: ' 157'
issue: '6'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1901.01643
month: '05'
oa: 1
oa_version: Preprint
publication: The Astronomical Journal
publication_identifier:
issn:
- 0004-6256
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: A hot Saturn orbiting an oscillating late subgiant discovered by TESS
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 157
year: '2019'
...
---
_id: '11613'
abstract:
- lang: eng
text: Over 2,000 stars were observed for 1 month with a high enough cadence in order
to look for acoustic modes during the survey phase of the Kepler mission. Solar-like
oscillations have been detected in about 540 stars. The question of why no oscillations
were detected in the remaining stars is still open. Previous works explained the
non-detection of modes with the high level of magnetic activity of the stars.
However, the sample of stars studied contained some classical pulsators and red
giants that could have biased the results. In this work, we revisit this analysis
on a cleaner sample of main-sequence solar-like stars that consists of 1,014 stars.
First we compute the predicted amplitude of the modes of that sample and for the
stars with detected oscillation and compare it to the noise at high frequency
in the power spectrum. We find that the stars with detected modes have an amplitude
to noise ratio larger than 0.94. We measure reliable rotation periods and the
associated photometric magnetic index for 684 stars out of the full sample and
in particular for 323 stars where the amplitude of the modes is predicted to be
high enough to be detected. We find that among these 323 stars 32% of them have
a level of magnetic activity larger than the Sun during its maximum activity,
explaining the non-detection of acoustic modes. Interestingly, magnetic activity
cannot be the primary reason responsible for the absence of detectable modes in
the remaining 68% of the stars without acoustic modes detected and with reliable
rotation periods. Thus, we investigate metallicity, inclination angle of the rotation
axis, and binarity as possible causes of low mode amplitudes. Using spectroscopic
observations for a subsample, we find that a low metallicity could be the reason
for suppressed modes. No clear correlation with binarity nor inclination is found.
We also derive the lower limit for our photometric activity index (of 20–30 ppm)
below which rotation and magnetic activity are not detected. Finally, with our
analysis we conclude that stars with a photometric activity index larger than
2,000 ppm have 98.3% probability of not having oscillations detected.
acknowledgement: This paper includes data collected by the Kepler mission. Funding
for the Kepler mission is provided by the NASA Science Mission directorate. Some
of the data presented in this paper were obtained from the Mikulski Archive for
Space Telescopes (MAST). STScI is operated by the Association of Universities for
Research in Astronomy, Inc., under NASA contract NAS5-26555. Partly Based on observations
obtained with the HERMES spectrograph on the Mercator Telescope, which was supported
by the Research Foundation—Flanders (FWO), Belgium, the Research Council of KU Leuven,
Belgium, the Fonds National de la Recherche Scientifique (F.R.S.-FNRS), Belgium,
the Royal Observatory of Belgium, the Observatoire de Genève, Switzerland, and the
Thüringer Landessternwarte Tautenburg, Germany. SM acknowledges support by the National
Aeronautics and Space Administration under Grant NNX15AF13G, by the National Science
Foundation grant AST-1411685, and the Ramon y Cajal fellowship number RYC-2015-17697.
RG acknowledges the support from PLATO and GOLF CNES grants. ÂS acknowledges the
support from National Aeronautics and Space Administration under Grant NNX17AF27G.
PB acknowledges the support of the MINECO under the fellowship program Juan de la
Cierva Incorporacion (IJCI-2015-26034).
article_number: '46'
article_processing_charge: No
article_type: original
author:
- first_name: Savita
full_name: Mathur, Savita
last_name: Mathur
- first_name: Rafael A.
full_name: García, Rafael A.
last_name: García
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: Ângela R.G.
full_name: Santos, Ângela R.G.
last_name: Santos
- first_name: Netsha
full_name: Santiago, Netsha
last_name: Santiago
- first_name: Paul G.
full_name: Beck, Paul G.
last_name: Beck
citation:
ama: Mathur S, García RA, Bugnet LA, Santos ÂRG, Santiago N, Beck PG. Revisiting
the impact of stellar magnetic activity on the detectability of solar-like oscillations
by Kepler. Frontiers in Astronomy and Space Sciences. 2019;6. doi:10.3389/fspas.2019.00046
apa: Mathur, S., García, R. A., Bugnet, L. A., Santos, Â. R. G., Santiago, N., &
Beck, P. G. (2019). Revisiting the impact of stellar magnetic activity on the
detectability of solar-like oscillations by Kepler. Frontiers in Astronomy
and Space Sciences. Frontiers Media. https://doi.org/10.3389/fspas.2019.00046
chicago: Mathur, Savita, Rafael A. García, Lisa Annabelle Bugnet, Ângela R.G. Santos,
Netsha Santiago, and Paul G. Beck. “Revisiting the Impact of Stellar Magnetic
Activity on the Detectability of Solar-like Oscillations by Kepler.” Frontiers
in Astronomy and Space Sciences. Frontiers Media, 2019. https://doi.org/10.3389/fspas.2019.00046.
ieee: S. Mathur, R. A. García, L. A. Bugnet, Â. R. G. Santos, N. Santiago, and P.
G. Beck, “Revisiting the impact of stellar magnetic activity on the detectability
of solar-like oscillations by Kepler,” Frontiers in Astronomy and Space Sciences,
vol. 6. Frontiers Media, 2019.
ista: Mathur S, García RA, Bugnet LA, Santos ÂRG, Santiago N, Beck PG. 2019. Revisiting
the impact of stellar magnetic activity on the detectability of solar-like oscillations
by Kepler. Frontiers in Astronomy and Space Sciences. 6, 46.
mla: Mathur, Savita, et al. “Revisiting the Impact of Stellar Magnetic Activity
on the Detectability of Solar-like Oscillations by Kepler.” Frontiers in Astronomy
and Space Sciences, vol. 6, 46, Frontiers Media, 2019, doi:10.3389/fspas.2019.00046.
short: S. Mathur, R.A. García, L.A. Bugnet, Â.R.G. Santos, N. Santiago, P.G. Beck,
Frontiers in Astronomy and Space Sciences 6 (2019).
date_created: 2022-07-18T14:00:36Z
date_published: 2019-07-10T00:00:00Z
date_updated: 2022-08-22T07:29:55Z
day: '10'
doi: 10.3389/fspas.2019.00046
extern: '1'
external_id:
arxiv:
- '1907.01415'
intvolume: ' 6'
keyword:
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1907.01415
month: '07'
oa: 1
oa_version: Preprint
publication: Frontiers in Astronomy and Space Sciences
publication_identifier:
eissn:
- 2296-987X
publication_status: published
publisher: Frontiers Media
quality_controlled: '1'
scopus_import: '1'
status: public
title: Revisiting the impact of stellar magnetic activity on the detectability of
solar-like oscillations by Kepler
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2019'
...
---
_id: '11615'
abstract:
- lang: eng
text: The recently published Kepler mission Data Release 25 (DR25) reported on ∼197 000
targets observed during the mission. Despite this, no wide search for red giants
showing solar-like oscillations have been made across all stars observed in Kepler’s
long-cadence mode. In this work, we perform this task using custom apertures on
the Kepler pixel files and detect oscillations in 21 914 stars, representing the
largest sample of solar-like oscillating stars to date. We measure their frequency
at maximum power, νmax, down to νmax≃4μHz and obtain log (g) estimates with a
typical uncertainty below 0.05 dex, which is superior to typical measurements
from spectroscopy. Additionally, the νmax distribution of our detections show
good agreement with results from a simulated model of the Milky Way, with a ratio
of observed to predicted stars of 0.992 for stars with 10<νmax<270μHz. Among our
red giant detections, we find 909 to be dwarf/subgiant stars whose flux signal
is polluted by a neighbouring giant as a result of using larger photometric apertures
than those used by the NASA Kepler science processing pipeline. We further find
that only 293 of the polluting giants are known Kepler targets. The remainder
comprises over 600 newly identified oscillating red giants, with many expected
to belong to the Galactic halo, serendipitously falling within the Kepler pixel
files of targeted stars.
acknowledgement: Funding for this Discovery mission is provided by NASA’s Science
mission Directorate. We thank the entire Kepler team without whom this investigation
would not be possible. DS is the recipient of an Australian Research Council Future
Fellowship (project number FT1400147). RAG acknowledges the support from CNES. SM
acknowledges support from NASA grant NNX15AF13G, NSF grant AST-1411685, and the
Ramon y Cajal fellowship number RYC-2015-17697. ILC acknowledges scholarship support
from the University of Sydney. We would like to thank Nicholas Barbara and Timothy
Bedding for providing us with a list of variable stars that helped to validate a
number of detections in this study. We also thank the group at the University of
Sydney for fruitful discussions. Finally, we gratefully acknowledge the support
of NVIDIA Corporation with the donation of the Titan Xp GPU used for this research.
article_processing_charge: No
article_type: original
author:
- first_name: Marc
full_name: Hon, Marc
last_name: Hon
- first_name: Dennis
full_name: Stello, Dennis
last_name: Stello
- first_name: Rafael A
full_name: García, Rafael A
last_name: García
- first_name: Savita
full_name: Mathur, Savita
last_name: Mathur
- first_name: Sanjib
full_name: Sharma, Sanjib
last_name: Sharma
- first_name: Isabel L
full_name: Colman, Isabel L
last_name: Colman
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
citation:
ama: Hon M, Stello D, García RA, et al. A search for red giant solar-like oscillations
in all Kepler data. Monthly Notices of the Royal Astronomical Society.
2019;485(4):5616-5630. doi:10.1093/mnras/stz622
apa: Hon, M., Stello, D., García, R. A., Mathur, S., Sharma, S., Colman, I. L.,
& Bugnet, L. A. (2019). A search for red giant solar-like oscillations in
all Kepler data. Monthly Notices of the Royal Astronomical Society. Oxford
University Press. https://doi.org/10.1093/mnras/stz622
chicago: Hon, Marc, Dennis Stello, Rafael A García, Savita Mathur, Sanjib Sharma,
Isabel L Colman, and Lisa Annabelle Bugnet. “A Search for Red Giant Solar-like
Oscillations in All Kepler Data.” Monthly Notices of the Royal Astronomical
Society. Oxford University Press, 2019. https://doi.org/10.1093/mnras/stz622.
ieee: M. Hon et al., “A search for red giant solar-like oscillations in all
Kepler data,” Monthly Notices of the Royal Astronomical Society, vol. 485,
no. 4. Oxford University Press, pp. 5616–5630, 2019.
ista: Hon M, Stello D, García RA, Mathur S, Sharma S, Colman IL, Bugnet LA. 2019.
A search for red giant solar-like oscillations in all Kepler data. Monthly Notices
of the Royal Astronomical Society. 485(4), 5616–5630.
mla: Hon, Marc, et al. “A Search for Red Giant Solar-like Oscillations in All Kepler
Data.” Monthly Notices of the Royal Astronomical Society, vol. 485, no.
4, Oxford University Press, 2019, pp. 5616–30, doi:10.1093/mnras/stz622.
short: M. Hon, D. Stello, R.A. García, S. Mathur, S. Sharma, I.L. Colman, L.A. Bugnet,
Monthly Notices of the Royal Astronomical Society 485 (2019) 5616–5630.
date_created: 2022-07-18T14:26:03Z
date_published: 2019-06-01T00:00:00Z
date_updated: 2022-08-22T07:35:19Z
day: '01'
doi: 10.1093/mnras/stz622
extern: '1'
external_id:
arxiv:
- '1903.00115'
intvolume: ' 485'
issue: '4'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- asteroseismology
- 'methods: data analysis'
- 'techniques: image processing'
- 'stars: oscillations'
- 'stars: statistics'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1903.00115
month: '06'
oa: 1
oa_version: Preprint
page: 5616-5630
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: A search for red giant solar-like oscillations in all Kepler data
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 485
year: '2019'
...
---
_id: '11614'
abstract:
- lang: eng
text: The NASA Transiting Exoplanet Survey Satellite (TESS) is about to provide
full-frame images of almost the entire sky. The amount of stellar data to be analysed
represents hundreds of millions stars, which is several orders of magnitude more
than the number of stars observed by the Convection, Rotation and planetary Transits
satellite (CoRoT), and NASA Kepler and K2 missions. We aim at automatically classifying
the newly observed stars with near real-time algorithms to better guide the subsequent
detailed studies. In this paper, we present a classification algorithm built to
recognise solar-like pulsators among classical pulsators. This algorithm relies
on the global amount of power contained in the power spectral density (PSD), also
known as the flicker in spectral power density (FliPer). Because each type of
pulsating star has a characteristic background or pulsation pattern, the shape
of the PSD at different frequencies can be used to characterise the type of pulsating
star. The FliPer classifier (FliPerClass) uses different FliPer parameters along
with the effective temperature as input parameters to feed a ML algorithm in order
to automatically classify the pulsating stars observed by TESS. Using noisy TESS-simulated
data from the TESS Asteroseismic Science Consortium (TASC), we classify pulsators
with a 98% accuracy. Among them, solar-like pulsating stars are recognised with
a 99% accuracy, which is of great interest for a further seismic analysis of these
stars, which are like our Sun. Similar results are obtained when we trained our
classifier and applied it to 27-day subsets of real Kepler data. FliPerClass is
part of the large TASC classification pipeline developed by the TESS Data for
Asteroseismology (T’DA) classification working group.
acknowledgement: We thank the enitre T’DA team for useful comments and discussions,
in particular Andrew Tkachenko. We also acknowledge Marc Hon, Keaton Bell, and James
Kuszlewicz for useful comments on the manuscript. L.B. and R.A.G. acknowledge the
support from PLATO and GOLF CNES grants. S.M. acknowledges support by the Ramon
y Cajal fellowship number RYC-2015-17697. O.J.H. and B.M.R. acknowledge the support
of the UK Science and Technology Facilities Council (STFC). M.N.L. acknowledges
the support of the ESA PRODEX programme (PEA 4000119301). Funding for the Stellar
Astrophysics Centre is provided by the Danish National Research Foundation (Grant
DNRF106).
article_number: A79
article_processing_charge: No
article_type: original
author:
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: R. A.
full_name: García, R. A.
last_name: García
- first_name: S.
full_name: Mathur, S.
last_name: Mathur
- first_name: G. R.
full_name: Davies, G. R.
last_name: Davies
- first_name: O. J.
full_name: Hall, O. J.
last_name: Hall
- first_name: M. N.
full_name: Lund, M. N.
last_name: Lund
- first_name: B. M.
full_name: Rendle, B. M.
last_name: Rendle
citation:
ama: 'Bugnet LA, García RA, Mathur S, et al. FliPerClass: In search of solar-like
pulsators among TESS targets. Astronomy & Astrophysics. 2019;624. doi:10.1051/0004-6361/201834780'
apa: 'Bugnet, L. A., García, R. A., Mathur, S., Davies, G. R., Hall, O. J., Lund,
M. N., & Rendle, B. M. (2019). FliPerClass: In search of solar-like pulsators
among TESS targets. Astronomy & Astrophysics. EDP Science. https://doi.org/10.1051/0004-6361/201834780'
chicago: 'Bugnet, Lisa Annabelle, R. A. García, S. Mathur, G. R. Davies, O. J. Hall,
M. N. Lund, and B. M. Rendle. “FliPerClass: In Search of Solar-like Pulsators
among TESS Targets.” Astronomy & Astrophysics. EDP Science, 2019. https://doi.org/10.1051/0004-6361/201834780.'
ieee: 'L. A. Bugnet et al., “FliPerClass: In search of solar-like pulsators
among TESS targets,” Astronomy & Astrophysics, vol. 624. EDP Science,
2019.'
ista: 'Bugnet LA, García RA, Mathur S, Davies GR, Hall OJ, Lund MN, Rendle BM. 2019.
FliPerClass: In search of solar-like pulsators among TESS targets. Astronomy &
Astrophysics. 624, A79.'
mla: 'Bugnet, Lisa Annabelle, et al. “FliPerClass: In Search of Solar-like Pulsators
among TESS Targets.” Astronomy & Astrophysics, vol. 624, A79, EDP Science,
2019, doi:10.1051/0004-6361/201834780.'
short: L.A. Bugnet, R.A. García, S. Mathur, G.R. Davies, O.J. Hall, M.N. Lund, B.M.
Rendle, Astronomy & Astrophysics 624 (2019).
date_created: 2022-07-18T14:13:34Z
date_published: 2019-04-19T00:00:00Z
date_updated: 2022-08-22T07:32:51Z
day: '19'
doi: 10.1051/0004-6361/201834780
extern: '1'
external_id:
arxiv:
- '1902.09854'
intvolume: ' 624'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1902.09854
month: '04'
oa: 1
oa_version: Preprint
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'FliPerClass: In search of solar-like pulsators among TESS targets'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 624
year: '2019'
...
---
_id: '11623'
abstract:
- lang: eng
text: Brightness variations due to dark spots on the stellar surface encode information
about stellar surface rotation and magnetic activity. In this work, we analyze
the Kepler long-cadence data of 26,521 main-sequence stars of spectral types M
and K in order to measure their surface rotation and photometric activity level.
Rotation-period estimates are obtained by the combination of a wavelet analysis
and autocorrelation function of the light curves. Reliable rotation estimates
are determined by comparing the results from the different rotation diagnostics
and four data sets. We also measure the photometric activity proxy Sph using the
amplitude of the flux variations on an appropriate timescale. We report rotation
periods and photometric activity proxies for about 60% of the sample, including
4431 targets for which McQuillan et al. did not report a rotation period. For
the common targets with rotation estimates in this study and in McQuillan et al.,
our rotation periods agree within 99%. In this work, we also identify potential
polluters, such as misclassified red giants and classical pulsator candidates.
Within the parameter range we study, there is a mild tendency for hotter stars
to have shorter rotation periods. The photometric activity proxy spans a wider
range of values with increasing effective temperature. The rotation period and
photometric activity proxy are also related, with Sph being larger for fast rotators.
Similar to McQuillan et al., we find a bimodal distribution of rotation periods.
acknowledgement: "The authors thank Róbert Szabó Paul G. Beck, Katrien Kolenberg,
and Isabel L. Colman for helping on the classification of stars. This paper includes
data collected by the Kepler mission and obtained from the MAST data archive at
the Space Telescope Science Institute (STScI). Funding for the Kepler mission is
provided by the National Aeronautics and Space Administration (NASA) Science Mission
Directorate. STScI is operated by the Association of Universities for Research in
Astronomy, Inc., under NASA contract NAS 5–26555. A.R.G.S. acknowledges the support
from NASA under grant NNX17AF27G. R.A.G. and L.B. acknowledge the support from PLATO
and GOLF CNES grants. S.M. acknowledges the support from the Ramon y Cajal fellowship
number RYC-2015-17697. T.S.M. acknowledges support from a Visiting Fellowship at
the Max Planck Institute for Solar System Research. This research has made use of
the NASA Exoplanet Archive, which is operated by the California Institute of Technology,
under contract with the National Aeronautics and Space Administration under the
Exoplanet Exploration Program.\r\n\r\nSoftware: KADACS (García et al. 2011), NumPy
(van der Walt et al. 2011), SciPy (Jones et al. 2001), Matplotlib (Hunter 2007).\r\n\r\nFacilities:
MAST - , Kepler Eclipsing Binary Catalog - , Exoplanet Archive. -"
article_number: '21'
article_processing_charge: No
article_type: original
author:
- first_name: A. R. G.
full_name: Santos, A. R. G.
last_name: Santos
- first_name: R. A.
full_name: García, R. A.
last_name: García
- first_name: S.
full_name: Mathur, S.
last_name: Mathur
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: J. L.
full_name: van Saders, J. L.
last_name: van Saders
- first_name: T. S.
full_name: Metcalfe, T. S.
last_name: Metcalfe
- first_name: G. V. A.
full_name: Simonian, G. V. A.
last_name: Simonian
- first_name: M. H.
full_name: Pinsonneault, M. H.
last_name: Pinsonneault
citation:
ama: Santos ARG, García RA, Mathur S, et al. Surface rotation and photometric activity
for Kepler targets. I. M and K main-sequence stars. The Astrophysical Journal
Supplement Series. 2019;244(1). doi:10.3847/1538-4365/ab3b56
apa: Santos, A. R. G., García, R. A., Mathur, S., Bugnet, L. A., van Saders, J.
L., Metcalfe, T. S., … Pinsonneault, M. H. (2019). Surface rotation and photometric
activity for Kepler targets. I. M and K main-sequence stars. The Astrophysical
Journal Supplement Series. IOP Publishing. https://doi.org/10.3847/1538-4365/ab3b56
chicago: Santos, A. R. G., R. A. García, S. Mathur, Lisa Annabelle Bugnet, J. L.
van Saders, T. S. Metcalfe, G. V. A. Simonian, and M. H. Pinsonneault. “Surface
Rotation and Photometric Activity for Kepler Targets. I. M and K Main-Sequence
Stars.” The Astrophysical Journal Supplement Series. IOP Publishing, 2019.
https://doi.org/10.3847/1538-4365/ab3b56.
ieee: A. R. G. Santos et al., “Surface rotation and photometric activity
for Kepler targets. I. M and K main-sequence stars,” The Astrophysical Journal
Supplement Series, vol. 244, no. 1. IOP Publishing, 2019.
ista: Santos ARG, García RA, Mathur S, Bugnet LA, van Saders JL, Metcalfe TS, Simonian
GVA, Pinsonneault MH. 2019. Surface rotation and photometric activity for Kepler
targets. I. M and K main-sequence stars. The Astrophysical Journal Supplement
Series. 244(1), 21.
mla: Santos, A. R. G., et al. “Surface Rotation and Photometric Activity for Kepler
Targets. I. M and K Main-Sequence Stars.” The Astrophysical Journal Supplement
Series, vol. 244, no. 1, 21, IOP Publishing, 2019, doi:10.3847/1538-4365/ab3b56.
short: A.R.G. Santos, R.A. García, S. Mathur, L.A. Bugnet, J.L. van Saders, T.S.
Metcalfe, G.V.A. Simonian, M.H. Pinsonneault, The Astrophysical Journal Supplement
Series 244 (2019).
date_created: 2022-07-19T09:21:58Z
date_published: 2019-09-19T00:00:00Z
date_updated: 2022-08-22T08:10:38Z
day: '19'
doi: 10.3847/1538-4365/ab3b56
extern: '1'
external_id:
arxiv:
- '1908.05222'
intvolume: ' 244'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'methods: data analysis'
- 'stars: activity'
- 'stars: low-mass'
- 'stars: rotation'
- starspots
- 'techniques: photometric'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1908.05222
month: '09'
oa: 1
oa_version: Preprint
publication: The Astrophysical Journal Supplement Series
publication_identifier:
issn:
- 0067-0049
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Surface rotation and photometric activity for Kepler targets. I. M and K main-sequence
stars
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 244
year: '2019'
...
---
_id: '11627'
abstract:
- lang: eng
text: 'For a solar-like star, the surface rotation evolves with time, allowing in
principle to estimate the age of a star from its surface rotation period. Here
we are interested in measuring surface rotation periods of solar-like stars observed
by the NASA mission Kepler. Different methods have been developed to track rotation
signals in Kepler photometric light curves: time-frequency analysis based on wavelet
techniques, autocorrelation and composite spectrum. We use the learning abilities
of random forest classifiers to take decisions during two crucial steps of the
analysis. First, given some input parameters, we discriminate the considered Kepler
targets between rotating MS stars, non-rotating MS stars, red giants, binaries
and pulsators. We then use a second classifier only on the MS rotating targets
to decide the best data analysis treatment.'
article_number: '1906.09609'
article_processing_charge: No
author:
- first_name: S. N.
full_name: Breton, S. N.
last_name: Breton
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: A. R. G.
full_name: Santos, A. R. G.
last_name: Santos
- first_name: A. Le
full_name: Saux, A. Le
last_name: Saux
- first_name: S.
full_name: Mathur, S.
last_name: Mathur
- first_name: P. L.
full_name: Palle, P. L.
last_name: Palle
- first_name: R. A.
full_name: Garcia, R. A.
last_name: Garcia
citation:
ama: Breton SN, Bugnet LA, Santos ARG, et al. Determining surface rotation periods
of solar-like stars observed by the Kepler mission using machine learning techniques.
arXiv. doi:10.48550/arXiv.1906.09609
apa: Breton, S. N., Bugnet, L. A., Santos, A. R. G., Saux, A. L., Mathur, S., Palle,
P. L., & Garcia, R. A. (n.d.). Determining surface rotation periods of solar-like
stars observed by the Kepler mission using machine learning techniques. arXiv.
https://doi.org/10.48550/arXiv.1906.09609
chicago: Breton, S. N., Lisa Annabelle Bugnet, A. R. G. Santos, A. Le Saux, S. Mathur,
P. L. Palle, and R. A. Garcia. “Determining Surface Rotation Periods of Solar-like
Stars Observed by the Kepler Mission Using Machine Learning Techniques.” ArXiv,
n.d. https://doi.org/10.48550/arXiv.1906.09609.
ieee: S. N. Breton et al., “Determining surface rotation periods of solar-like
stars observed by the Kepler mission using machine learning techniques,” arXiv.
.
ista: Breton SN, Bugnet LA, Santos ARG, Saux AL, Mathur S, Palle PL, Garcia RA.
Determining surface rotation periods of solar-like stars observed by the Kepler
mission using machine learning techniques. arXiv, 1906.09609.
mla: Breton, S. N., et al. “Determining Surface Rotation Periods of Solar-like Stars
Observed by the Kepler Mission Using Machine Learning Techniques.” ArXiv,
1906.09609, doi:10.48550/arXiv.1906.09609.
short: S.N. Breton, L.A. Bugnet, A.R.G. Santos, A.L. Saux, S. Mathur, P.L. Palle,
R.A. Garcia, ArXiv (n.d.).
date_created: 2022-07-20T11:18:53Z
date_published: 2019-06-23T00:00:00Z
date_updated: 2022-08-22T08:16:53Z
day: '23'
doi: 10.48550/arXiv.1906.09609
extern: '1'
external_id:
arxiv:
- '1906.09609'
keyword:
- asteroseismology
- rotation
- solar-like stars
- kepler
- machine learning
- random forest
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1906.09609
month: '06'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
status: public
title: Determining surface rotation periods of solar-like stars observed by the Kepler
mission using machine learning techniques
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '11630'
abstract:
- lang: eng
text: 'The second mission of NASA’s Kepler satellite, K2, has collected hundreds
of thousands of lightcurves for stars close to the ecliptic plane. This new sample
could increase the number of known pulsating stars and then improve our understanding
of those stars. For the moment only a few stars have been properly classified
and published. In this work, we present a method to automaticly classify K2 pulsating
stars using a Machine Learning technique called Random Forest. The objective is
to sort out the stars in four classes: red giant (RG), main-sequence Solar-like
stars (SL), classical pulsators (PULS) and Other. To do this we use the effective
temperatures and the luminosities of the stars as well as the FliPer features,
that measures the amount of power contained in the power spectral density. The
classifier now retrieves the right classification for more than 80% of the stars.'
article_number: '1906.09611'
article_processing_charge: No
author:
- first_name: A. Le
full_name: Saux, A. Le
last_name: Saux
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: S.
full_name: Mathur, S.
last_name: Mathur
- first_name: S. N.
full_name: Breton, S. N.
last_name: Breton
- first_name: R. A.
full_name: Garcia, R. A.
last_name: Garcia
citation:
ama: Saux AL, Bugnet LA, Mathur S, Breton SN, Garcia RA. Automatic classification
of K2 pulsating stars using machine learning techniques. arXiv. doi:10.48550/arXiv.1906.09611
apa: Saux, A. L., Bugnet, L. A., Mathur, S., Breton, S. N., & Garcia, R. A.
(n.d.). Automatic classification of K2 pulsating stars using machine learning
techniques. arXiv. https://doi.org/10.48550/arXiv.1906.09611
chicago: Saux, A. Le, Lisa Annabelle Bugnet, S. Mathur, S. N. Breton, and R. A.
Garcia. “Automatic Classification of K2 Pulsating Stars Using Machine Learning
Techniques.” ArXiv, n.d. https://doi.org/10.48550/arXiv.1906.09611.
ieee: A. L. Saux, L. A. Bugnet, S. Mathur, S. N. Breton, and R. A. Garcia, “Automatic
classification of K2 pulsating stars using machine learning techniques,” arXiv.
.
ista: Saux AL, Bugnet LA, Mathur S, Breton SN, Garcia RA. Automatic classification
of K2 pulsating stars using machine learning techniques. arXiv, 1906.09611.
mla: Saux, A. Le, et al. “Automatic Classification of K2 Pulsating Stars Using Machine
Learning Techniques.” ArXiv, 1906.09611, doi:10.48550/arXiv.1906.09611.
short: A.L. Saux, L.A. Bugnet, S. Mathur, S.N. Breton, R.A. Garcia, ArXiv (n.d.).
date_created: 2022-07-21T06:57:10Z
date_published: 2019-06-23T00:00:00Z
date_updated: 2022-08-22T08:20:29Z
day: '23'
doi: 10.48550/arXiv.1906.09611
extern: '1'
external_id:
arxiv:
- '1906.09611'
keyword:
- asteroseismology - methods
- data analysis - thecniques
- machine learning - stars
- oscillations
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1906.09611
month: '06'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
status: public
title: Automatic classification of K2 pulsating stars using machine learning techniques
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '11826'
abstract:
- lang: eng
text: "The diameter, radius and eccentricities are natural graph parameters. While
these problems have been studied extensively, there are no known dynamic algorithms
for them beyond the ones that follow from trivial recomputation after each update
or from solving dynamic All-Pairs Shortest Paths (APSP), which is very computationally
intensive. This is the situation for dynamic approximation algorithms as well,
and even if only edge insertions or edge deletions need to be supported.\r\nThis
paper provides a comprehensive study of the dynamic approximation of Diameter,
Radius and Eccentricities, providing both conditional lower bounds, and new algorithms
whose bounds are optimal under popular hypotheses in fine-grained complexity.
Some of the highlights include:\r\n- Under popular hardness hypotheses, there
can be no significantly better fully dynamic approximation algorithms than recomputing
the answer after each update, or maintaining full APSP.\r\n- Nearly optimal partially
dynamic (incremental/decremental) algorithms can be achieved via efficient reductions
to (incremental/decremental) maintenance of Single-Source Shortest Paths. For
instance, a nearly (3/2+epsilon)-approximation to Diameter in directed or undirected
n-vertex, m-edge graphs can be maintained decrementally in total time m^{1+o(1)}sqrt{n}/epsilon^2.
This nearly matches the static 3/2-approximation algorithm for the problem that
is known to be conditionally optimal."
alternative_title:
- LIPIcs
article_number: '13'
article_processing_charge: No
author:
- first_name: Bertie
full_name: Ancona, Bertie
last_name: Ancona
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Liam
full_name: Roditty, Liam
last_name: Roditty
- first_name: Virginia Vassilevska
full_name: Williams, Virginia Vassilevska
last_name: Williams
- first_name: Nicole
full_name: Wein, Nicole
last_name: Wein
citation:
ama: 'Ancona B, Henzinger MH, Roditty L, Williams VV, Wein N. Algorithms and hardness
for diameter in dynamic graphs. In: 46th International Colloquium on Automata,
Languages, and Programming. Vol 132. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik; 2019. doi:10.4230/LIPICS.ICALP.2019.13'
apa: 'Ancona, B., Henzinger, M. H., Roditty, L., Williams, V. V., & Wein, N.
(2019). Algorithms and hardness for diameter in dynamic graphs. In 46th International
Colloquium on Automata, Languages, and Programming (Vol. 132). Patras, Greece:
Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPICS.ICALP.2019.13'
chicago: Ancona, Bertie, Monika H Henzinger, Liam Roditty, Virginia Vassilevska
Williams, and Nicole Wein. “Algorithms and Hardness for Diameter in Dynamic Graphs.”
In 46th International Colloquium on Automata, Languages, and Programming,
Vol. 132. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019. https://doi.org/10.4230/LIPICS.ICALP.2019.13.
ieee: B. Ancona, M. H. Henzinger, L. Roditty, V. V. Williams, and N. Wein, “Algorithms
and hardness for diameter in dynamic graphs,” in 46th International Colloquium
on Automata, Languages, and Programming, Patras, Greece, 2019, vol. 132.
ista: 'Ancona B, Henzinger MH, Roditty L, Williams VV, Wein N. 2019. Algorithms
and hardness for diameter in dynamic graphs. 46th International Colloquium on
Automata, Languages, and Programming. ICALP: International Colloquium on Automata,
Languages, and Programming, LIPIcs, vol. 132, 13.'
mla: Ancona, Bertie, et al. “Algorithms and Hardness for Diameter in Dynamic Graphs.”
46th International Colloquium on Automata, Languages, and Programming,
vol. 132, 13, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019, doi:10.4230/LIPICS.ICALP.2019.13.
short: B. Ancona, M.H. Henzinger, L. Roditty, V.V. Williams, N. Wein, in:, 46th
International Colloquium on Automata, Languages, and Programming, Schloss Dagstuhl
- Leibniz-Zentrum für Informatik, 2019.
conference:
end_date: 2019-07-12
location: Patras, Greece
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 2019-07-09
date_created: 2022-08-12T08:14:51Z
date_published: 2019-07-04T00:00:00Z
date_updated: 2023-02-16T10:48:24Z
day: '04'
doi: 10.4230/LIPICS.ICALP.2019.13
extern: '1'
external_id:
arxiv:
- '811.12527'
intvolume: ' 132'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.4230/LIPIcs.ICALP.2019.13
month: '07'
oa: 1
oa_version: Published Version
publication: 46th International Colloquium on Automata, Languages, and Programming
publication_identifier:
isbn:
- 978-3-95977-109-2
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Algorithms and hardness for diameter in dynamic graphs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 132
year: '2019'
...
---
_id: '11850'
abstract:
- lang: eng
text: 'Modern networked systems are increasingly reconfigurable, enabling demand-aware
infrastructures whose resources can be adjusted according to the workload they
currently serve. Such dynamic adjustments can be exploited to improve network
utilization and hence performance, by moving frequently interacting communication
partners closer, e.g., collocating them in the same server or datacenter. However,
dynamically changing the embedding of workloads is algorithmically challenging:
communication patterns are often not known ahead of time, but must be learned.
During the learning process, overheads related to unnecessary moves (i.e., re-embeddings)
should be minimized. This paper studies a fundamental model which captures the
tradeoff between the benefits and costs of dynamically collocating communication
partners on l servers, in an online manner. Our main contribution is a distributed
online algorithm which is asymptotically almost optimal, i.e., almost matches
the lower bound (also derived in this paper) on the competitive ratio of any (distributed
or centralized) online algorithm.'
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Stefan
full_name: Neumann, Stefan
last_name: Neumann
- first_name: Stefan
full_name: Schmid, Stefan
last_name: Schmid
citation:
ama: 'Henzinger MH, Neumann S, Schmid S. Efficient distributed workload (re-)embedding.
In: SIGMETRICS’19: International Conference on Measurement and Modeling of
Computer Systems. Association for Computing Machinery; 2019:43–44. doi:10.1145/3309697.3331503'
apa: 'Henzinger, M. H., Neumann, S., & Schmid, S. (2019). Efficient distributed
workload (re-)embedding. In SIGMETRICS’19: International Conference on Measurement
and Modeling of Computer Systems (pp. 43–44). Phoenix, AZ, United States:
Association for Computing Machinery. https://doi.org/10.1145/3309697.3331503'
chicago: 'Henzinger, Monika H, Stefan Neumann, and Stefan Schmid. “Efficient Distributed
Workload (Re-)Embedding.” In SIGMETRICS’19: International Conference on Measurement
and Modeling of Computer Systems, 43–44. Association for Computing Machinery,
2019. https://doi.org/10.1145/3309697.3331503.'
ieee: 'M. H. Henzinger, S. Neumann, and S. Schmid, “Efficient distributed workload
(re-)embedding,” in SIGMETRICS’19: International Conference on Measurement
and Modeling of Computer Systems, Phoenix, AZ, United States, 2019, pp. 43–44.'
ista: 'Henzinger MH, Neumann S, Schmid S. 2019. Efficient distributed workload (re-)embedding.
SIGMETRICS’19: International Conference on Measurement and Modeling of Computer
Systems. SIGMETRICS: International Conference on Measurement and Modeling of Computer
Systems, 43–44.'
mla: 'Henzinger, Monika H., et al. “Efficient Distributed Workload (Re-)Embedding.”
SIGMETRICS’19: International Conference on Measurement and Modeling of Computer
Systems, Association for Computing Machinery, 2019, pp. 43–44, doi:10.1145/3309697.3331503.'
short: 'M.H. Henzinger, S. Neumann, S. Schmid, in:, SIGMETRICS’19: International
Conference on Measurement and Modeling of Computer Systems, Association for Computing
Machinery, 2019, pp. 43–44.'
conference:
end_date: 2019-06-28
location: Phoenix, AZ, United States
name: 'SIGMETRICS: International Conference on Measurement and Modeling of Computer
Systems'
start_date: 2019-06-24
date_created: 2022-08-16T07:14:57Z
date_published: 2019-06-20T00:00:00Z
date_updated: 2023-02-17T09:41:45Z
day: '20'
doi: 10.1145/3309697.3331503
extern: '1'
external_id:
arxiv:
- '1904.05474'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1904.05474
month: '06'
oa: 1
oa_version: Preprint
page: 43–44
publication: 'SIGMETRICS''19: International Conference on Measurement and Modeling
of Computer Systems'
publication_identifier:
isbn:
- 978-1-4503-6678-6
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient distributed workload (re-)embedding
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '11847'
abstract:
- lang: eng
text: This paper serves as a user guide to the Vienna graph clustering framework.
We review our general memetic algorithm, VieClus, to tackle the graph clustering
problem. A key component of our contribution are natural recombine operators that
employ ensemble clusterings as well as multi-level techniques. Lastly, we combine
these techniques with a scalable communication protocol, producing a system that
is able to compute high-quality solutions in a short amount of time. After giving
a description of the algorithms employed, we establish the connection of the graph
clustering problem to protein–protein interaction networks and moreover give a
description on how the software can be used, what file formats are expected, and
how this can be used to find functional groups in protein–protein interaction
networks.
alternative_title:
- Methods in Molecular Biology
article_processing_charge: No
author:
- first_name: Sonja
full_name: Biedermann, Sonja
last_name: Biedermann
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Christian
full_name: Schulz, Christian
last_name: Schulz
- first_name: Bernhard
full_name: Schuster, Bernhard
last_name: Schuster
citation:
ama: 'Biedermann S, Henzinger MH, Schulz C, Schuster B. Vienna Graph Clustering.
In: Canzar S, Rojas Ringeling F, eds. Protein-Protein Interaction Networks.
Vol 2074. MIMB. Springer Nature; 2019:215–231. doi:10.1007/978-1-4939-9873-9_16'
apa: Biedermann, S., Henzinger, M. H., Schulz, C., & Schuster, B. (2019). Vienna
Graph Clustering. In S. Canzar & F. Rojas Ringeling (Eds.), Protein-Protein
Interaction Networks (Vol. 2074, pp. 215–231). Springer Nature. https://doi.org/10.1007/978-1-4939-9873-9_16
chicago: Biedermann, Sonja, Monika H Henzinger, Christian Schulz, and Bernhard Schuster.
“Vienna Graph Clustering.” In Protein-Protein Interaction Networks, edited
by Stefan Canzar and Francisca Rojas Ringeling, 2074:215–231. MIMB. Springer Nature,
2019. https://doi.org/10.1007/978-1-4939-9873-9_16.
ieee: S. Biedermann, M. H. Henzinger, C. Schulz, and B. Schuster, “Vienna Graph
Clustering,” in Protein-Protein Interaction Networks, vol. 2074, S. Canzar
and F. Rojas Ringeling, Eds. Springer Nature, 2019, pp. 215–231.
ista: 'Biedermann S, Henzinger MH, Schulz C, Schuster B. 2019.Vienna Graph Clustering.
In: Protein-Protein Interaction Networks. Methods in Molecular Biology, vol. 2074,
215–231.'
mla: Biedermann, Sonja, et al. “Vienna Graph Clustering.” Protein-Protein Interaction
Networks, edited by Stefan Canzar and Francisca Rojas Ringeling, vol. 2074,
Springer Nature, 2019, pp. 215–231, doi:10.1007/978-1-4939-9873-9_16.
short: S. Biedermann, M.H. Henzinger, C. Schulz, B. Schuster, in:, S. Canzar, F.
Rojas Ringeling (Eds.), Protein-Protein Interaction Networks, Springer Nature,
2019, pp. 215–231.
date_created: 2022-08-16T06:54:48Z
date_published: 2019-10-04T00:00:00Z
date_updated: 2023-02-17T09:34:26Z
day: '04'
doi: 10.1007/978-1-4939-9873-9_16
editor:
- first_name: Stefan
full_name: Canzar, Stefan
last_name: Canzar
- first_name: Francisca
full_name: Rojas Ringeling, Francisca
last_name: Rojas Ringeling
extern: '1'
external_id:
pmid:
- '31583641'
intvolume: ' 2074'
language:
- iso: eng
month: '10'
oa_version: None
page: 215–231
pmid: 1
publication: Protein-Protein Interaction Networks
publication_identifier:
eisbn:
- '9781493998739'
eissn:
- 1940-6029
isbn:
- '9781493998722'
issn:
- 1064-3745
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: MIMB
status: public
title: Vienna Graph Clustering
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2074
year: '2019'
...
---
_id: '11853'
abstract:
- lang: eng
text: We present a deterministic dynamic algorithm for maintaining a (1+ε)f-approximate
minimum cost set cover with O(f log(Cn)/ε^2) amortized update time, when the input
set system is undergoing element insertions and deletions. Here, n denotes the
number of elements, each element appears in at most f sets, and the cost of each
set lies in the range [1/C, 1]. Our result, together with that of Gupta~et~al.~[STOC'17],
implies that there is a deterministic algorithm for this problem with O(f log(Cn))
amortized update time and O(min(log n, f)) -approximation ratio, which nearly
matches the polynomial-time hardness of approximation for minimum set cover in
the static setting. Our update time is only O(log (Cn)) away from a trivial lower
bound. Prior to our work, the previous best approximation ratio guaranteed by
deterministic algorithms was O(f^2), which was due to Bhattacharya~et~al.~[ICALP`15].
In contrast, the only result that guaranteed O(f) -approximation was obtained
very recently by Abboud~et~al.~[STOC`19], who designed a dynamic algorithm with
(1+ε)f-approximation ratio and O(f^2 log n/ε) amortized update time. Besides the
extra O(f) factor in the update time compared to our and Gupta~et~al.'s results,
the Abboud~et~al.~algorithm is randomized, and works only when the adversary is
oblivious and the sets are unweighted (each set has the same cost). We achieve
our result via the primal-dual approach, by maintaining a fractional packing solution
as a dual certificate. This approach was pursued previously by Bhattacharya~et~al.~and
Gupta~et~al., but not in the recent paper by Abboud~et~al. Unlike previous primal-dual
algorithms that try to satisfy some local constraints for individual sets at all
time, our algorithm basically waits until the dual solution changes significantly
globally, and fixes the solution only where the fix is needed.
article_processing_charge: No
author:
- first_name: Sayan
full_name: Bhattacharya, Sayan
last_name: Bhattacharya
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Danupon
full_name: Nanongkai, Danupon
last_name: Nanongkai
citation:
ama: 'Bhattacharya S, Henzinger MH, Nanongkai D. A new deterministic algorithm for
dynamic set cover. In: 60th Annual Symposium on Foundations of Computer Science.
Institute of Electrical and Electronics Engineers; 2019:406-423. doi:10.1109/focs.2019.00033'
apa: 'Bhattacharya, S., Henzinger, M. H., & Nanongkai, D. (2019). A new deterministic
algorithm for dynamic set cover. In 60th Annual Symposium on Foundations of
Computer Science (pp. 406–423). Baltimore, MD, United States: Institute of
Electrical and Electronics Engineers. https://doi.org/10.1109/focs.2019.00033'
chicago: Bhattacharya, Sayan, Monika H Henzinger, and Danupon Nanongkai. “A New
Deterministic Algorithm for Dynamic Set Cover.” In 60th Annual Symposium on
Foundations of Computer Science, 406–23. Institute of Electrical and Electronics
Engineers, 2019. https://doi.org/10.1109/focs.2019.00033.
ieee: S. Bhattacharya, M. H. Henzinger, and D. Nanongkai, “A new deterministic algorithm
for dynamic set cover,” in 60th Annual Symposium on Foundations of Computer
Science, Baltimore, MD, United States, 2019, pp. 406–423.
ista: 'Bhattacharya S, Henzinger MH, Nanongkai D. 2019. A new deterministic algorithm
for dynamic set cover. 60th Annual Symposium on Foundations of Computer Science.
FOCS: Annual Symposium on Foundations of Computer Science, 406–423.'
mla: Bhattacharya, Sayan, et al. “A New Deterministic Algorithm for Dynamic Set
Cover.” 60th Annual Symposium on Foundations of Computer Science, Institute
of Electrical and Electronics Engineers, 2019, pp. 406–23, doi:10.1109/focs.2019.00033.
short: S. Bhattacharya, M.H. Henzinger, D. Nanongkai, in:, 60th Annual Symposium
on Foundations of Computer Science, Institute of Electrical and Electronics Engineers,
2019, pp. 406–423.
conference:
end_date: 2019-11-12
location: Baltimore, MD, United States
name: 'FOCS: Annual Symposium on Foundations of Computer Science'
start_date: 2019-11-09
date_created: 2022-08-16T08:00:00Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2023-02-17T09:50:37Z
day: '01'
doi: 10.1109/focs.2019.00033
extern: '1'
external_id:
arxiv:
- '1909.11600'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1909.11600
month: '11'
oa: 1
oa_version: Preprint
page: 406-423
publication: 60th Annual Symposium on Foundations of Computer Science
publication_identifier:
eisbn:
- 978-1-7281-4952-3
isbn:
- 978-1-7281-4953-0
issn:
- 2575-8454
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: A new deterministic algorithm for dynamic set cover
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '11851'
abstract:
- lang: eng
text: The minimum cut problem for an undirected edge-weighted graph asks us to divide
its set of nodes into two blocks while minimizing the weighted sum of the cut
edges. In this paper, we engineer the fastest known exact algorithm for the problem.
State-of-the-art algorithms like the algorithm of Padberg and Rinaldi or the algorithm
of Nagamochi, Ono and Ibaraki identify edges that can be contracted to reduce
the graph size such that at least one minimum cut is maintained in the contracted
graph. Our algorithm achieves improvements in running time over these algorithms
by a multitude of techniques. First, we use a recently developed fast and parallel
inexact minimum cut algorithm to obtain a better bound for the problem. Afterwards,
we use reductions that depend on this bound to reduce the size of the graph much
faster than previously possible. We use improved data structures to further lower
the running time of our algorithm. Additionally, we parallelize the contraction
routines of Nagamochi et al. . Overall, we arrive at a system that significantly
outperforms the fastest state-of-the-art solvers for the exact minimum cut problem.
article_number: '8820968'
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Alexander
full_name: Noe, Alexander
last_name: Noe
- first_name: Christian
full_name: Schulz, Christian
last_name: Schulz
citation:
ama: 'Henzinger MH, Noe A, Schulz C. Shared-memory exact minimum cuts. In: 33rd
International Parallel and Distributed Processing Symposium. Institute of
Electrical and Electronics Engineers; 2019. doi:10.1109/ipdps.2019.00013'
apa: 'Henzinger, M. H., Noe, A., & Schulz, C. (2019). Shared-memory exact minimum
cuts. In 33rd International Parallel and Distributed Processing Symposium.
Rio de Janeiro, Brazil: Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/ipdps.2019.00013'
chicago: Henzinger, Monika H, Alexander Noe, and Christian Schulz. “Shared-Memory
Exact Minimum Cuts.” In 33rd International Parallel and Distributed Processing
Symposium. Institute of Electrical and Electronics Engineers, 2019. https://doi.org/10.1109/ipdps.2019.00013.
ieee: M. H. Henzinger, A. Noe, and C. Schulz, “Shared-memory exact minimum cuts,”
in 33rd International Parallel and Distributed Processing Symposium, Rio
de Janeiro, Brazil, 2019.
ista: 'Henzinger MH, Noe A, Schulz C. 2019. Shared-memory exact minimum cuts. 33rd
International Parallel and Distributed Processing Symposium. IPDPS: International
Parallel and Distributed Processing Symposium, 8820968.'
mla: Henzinger, Monika H., et al. “Shared-Memory Exact Minimum Cuts.” 33rd International
Parallel and Distributed Processing Symposium, 8820968, Institute of Electrical
and Electronics Engineers, 2019, doi:10.1109/ipdps.2019.00013.
short: M.H. Henzinger, A. Noe, C. Schulz, in:, 33rd International Parallel and Distributed
Processing Symposium, Institute of Electrical and Electronics Engineers, 2019.
conference:
end_date: 2019-05-24
location: Rio de Janeiro, Brazil
name: 'IPDPS: International Parallel and Distributed Processing Symposium'
start_date: 2019-05-20
date_created: 2022-08-16T07:25:23Z
date_published: 2019-05-01T00:00:00Z
date_updated: 2023-02-21T16:30:34Z
day: '01'
doi: 10.1109/ipdps.2019.00013
extern: '1'
external_id:
arxiv:
- '1808.05458'
language:
- iso: eng
main_file_link:
- url: https://arxiv.org/abs/1808.05458
month: '05'
oa_version: Preprint
publication: 33rd International Parallel and Distributed Processing Symposium
publication_identifier:
eisbn:
- 978-1-7281-1246-6
eissn:
- 1530-2075
isbn:
- 978-1-7281-1247-3
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
related_material:
record:
- id: '11851'
relation: later_version
status: public
scopus_import: '1'
status: public
title: Shared-memory exact minimum cuts
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '11865'
abstract:
- lang: eng
text: We present the first sublinear-time algorithm that can compute the edge connectivity
λ of a network exactly on distributed message-passing networks (the CONGEST model),
as long as the network contains no multi-edge. We present the first sublinear-time
algorithm for a distributed message-passing network sto compute its edge connectivity
λ exactly in the CONGEST model, as long as there are no parallel edges. Our algorithm
takes Õ(n1−1/353D1/353+n1−1/706) time to compute λ and a cut of cardinality λ
with high probability, where n and D are the number of nodes and the diameter
of the network, respectively, and Õ hides polylogarithmic factors. This running
time is sublinear in n (i.e. Õ(n1−є)) whenever D is. Previous sublinear-time distributed
algorithms can solve this problem either (i) exactly only when λ=O(n1/8−є) [Thurimella
PODC’95; Pritchard, Thurimella, ACM Trans. Algorithms’11; Nanongkai, Su, DISC’14]
or (ii) approximately [Ghaffari, Kuhn, DISC’13; Nanongkai, Su, DISC’14]. To achieve
this we develop and combine several new techniques. First, we design the first
distributed algorithm that can compute a k-edge connectivity certificate for any
k=O(n1−є) in time Õ(√nk+D). The previous sublinear-time algorithm can do so only
when k=o(√n) [Thurimella PODC’95]. In fact, our algorithm can be turned into the
first parallel algorithm with polylogarithmic depth and near-linear work. Previous
near-linear work algorithms are essentially sequential and previous polylogarithmic-depth
algorithms require Ω(mk) work in the worst case (e.g. [Karger, Motwani, STOC’93]).
Second, we show that by combining the recent distributed expander decomposition
technique of [Chang, Pettie, Zhang, SODA’19] with techniques from the sequential
deterministic edge connectivity algorithm of [Kawarabayashi, Thorup, STOC’15],
we can decompose the network into a sublinear number of clusters with small average
diameter and without any mincut separating a cluster (except the “trivial” ones).
This leads to a simplification of the Kawarabayashi-Thorup framework (except that
we are randomized while they are deterministic). This might make this framework
more useful in other models of computation. Finally, by extending the tree packing
technique from [Karger STOC’96], we can find the minimum cut in time proportional
to the number of components. As a byproduct of this technique, we obtain an Õ(n)-time
algorithm for computing exact minimum cut for weighted graphs.
article_processing_charge: No
author:
- first_name: Mohit
full_name: Daga, Mohit
last_name: Daga
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Danupon
full_name: Nanongkai, Danupon
last_name: Nanongkai
- first_name: Thatchaphol
full_name: Saranurak, Thatchaphol
last_name: Saranurak
citation:
ama: 'Daga M, Henzinger MH, Nanongkai D, Saranurak T. Distributed edge connectivity
in sublinear time. In: Proceedings of the 51st Annual ACM SIGACT Symposium
on Theory of Computing. Association for Computing Machinery; 2019:343–354.
doi:10.1145/3313276.3316346'
apa: 'Daga, M., Henzinger, M. H., Nanongkai, D., & Saranurak, T. (2019). Distributed
edge connectivity in sublinear time. In Proceedings of the 51st Annual ACM
SIGACT Symposium on Theory of Computing (pp. 343–354). Phoenix, AZ, United
States: Association for Computing Machinery. https://doi.org/10.1145/3313276.3316346'
chicago: Daga, Mohit, Monika H Henzinger, Danupon Nanongkai, and Thatchaphol Saranurak.
“Distributed Edge Connectivity in Sublinear Time.” In Proceedings of the 51st
Annual ACM SIGACT Symposium on Theory of Computing, 343–354. Association for
Computing Machinery, 2019. https://doi.org/10.1145/3313276.3316346.
ieee: M. Daga, M. H. Henzinger, D. Nanongkai, and T. Saranurak, “Distributed edge
connectivity in sublinear time,” in Proceedings of the 51st Annual ACM SIGACT
Symposium on Theory of Computing, Phoenix, AZ, United States, 2019, pp. 343–354.
ista: 'Daga M, Henzinger MH, Nanongkai D, Saranurak T. 2019. Distributed edge connectivity
in sublinear time. Proceedings of the 51st Annual ACM SIGACT Symposium on Theory
of Computing. STOC: Symposium on Theory of Computing, 343–354.'
mla: Daga, Mohit, et al. “Distributed Edge Connectivity in Sublinear Time.” Proceedings
of the 51st Annual ACM SIGACT Symposium on Theory of Computing, Association
for Computing Machinery, 2019, pp. 343–354, doi:10.1145/3313276.3316346.
short: M. Daga, M.H. Henzinger, D. Nanongkai, T. Saranurak, in:, Proceedings of
the 51st Annual ACM SIGACT Symposium on Theory of Computing, Association for Computing
Machinery, 2019, pp. 343–354.
conference:
end_date: 2019-06-26
location: Phoenix, AZ, United States
name: 'STOC: Symposium on Theory of Computing'
start_date: 2019-06-23
date_created: 2022-08-16T09:11:17Z
date_published: 2019-06-01T00:00:00Z
date_updated: 2023-02-17T10:26:25Z
day: '01'
doi: 10.1145/3313276.3316346
extern: '1'
external_id:
arxiv:
- '1904.04341'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1904.04341
month: '06'
oa: 1
oa_version: Preprint
page: 343–354
publication: Proceedings of the 51st Annual ACM SIGACT Symposium on Theory of Computing
publication_identifier:
isbn:
- 978-1-4503-6705-9
issn:
- 0737-8017
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distributed edge connectivity in sublinear time
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '11871'
abstract:
- lang: eng
text: "Many dynamic graph algorithms have an amortized update time, rather than
a stronger worst-case guarantee. But amortized data structures are not suitable
for real-time systems, where each individual operation has to be executed quickly.
For this reason, there exist many recent randomized results that aim to provide
a guarantee stronger than amortized expected. The strongest possible guarantee
for a randomized algorithm is that it is always correct (Las Vegas), and has high-probability
worst-case update time, which gives a bound on the time for each individual operation
that holds with high probability.\r\n\r\nIn this paper we present the first polylogarithmic
high-probability worst-case time bounds for the dynamic spanner and the dynamic
maximal matching problem.\r\n\r\n1.\t\r\nFor dynamic spanner, the only known o(n)
worst-case bounds were O(n3/4) high-probability worst-case update time for maintaining
a 3-spanner, and O(n5/9) for maintaining a 5-spanner. We give a O(1)k log3(n)
high-probability worst-case time bound for maintaining a (2k – 1)-spanner, which
yields the first worst-case polylog update time for all constant k. (All the results
above maintain the optimal tradeoff of stretch 2k – 1 and Õ(n1+1/k) edges.)\r\n\r\n2.\t\r\nFor
dynamic maximal matching, or dynamic 2-approximate maximum matching, no algorithm
with o(n) worst-case time bound was known and we present an algorithm with O(log5
(n)) high-probability worst-case time; similar worst-case bounds existed only
for maintaining a matching that was (2 + ∊)-approximate, and hence not maximal.\r\n\r\nOur
results are achieved using a new approach for converting amortized guarantees
to worst-case ones for randomized data structures by going through a third type
of guarantee, which is a middle ground between the two above: an algorithm is
said to have worst-case expected update time α if for every update σ, the expected
time to process σ is at most α. Although stronger than amortized expected, the
worst-case expected guarantee does not resolve the fundamental problem of amortization:
a worst-case expected update time of O(1) still allows for the possibility that
every 1/f(n) updates requires Θ(f(n)) time to process, for arbitrarily high f(n).
In this paper we present a black-box reduction that converts any data structure
with worst-case expected update time into one with a high-probability worst-case
update time: the query time remains the same, while the update time increases
by a factor of O(log2(n)).\r\n\r\nThus we achieve our results in two steps: (1)
First we show how to convert existing dynamic graph algorithms with amortized
expected polylogarithmic running times into algorithms with worst-case expected
polylogarithmic running times. (2) Then we use our black-box reduction to achieve
the polylogarithmic high-probability worst-case time bound. All our algorithms
are Las-Vegas-type algorithms."
article_processing_charge: No
author:
- first_name: Aaron
full_name: Bernstein, Aaron
last_name: Bernstein
- first_name: Sebastian
full_name: Forster, Sebastian
last_name: Forster
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Bernstein A, Forster S, Henzinger MH. A deamortization approach for dynamic
spanner and dynamic maximal matching. In: 30th Annual ACM-SIAM Symposium on
Discrete Algorithms. Society for Industrial and Applied Mathematics; 2019:1899-1918.
doi:10.1137/1.9781611975482.115'
apa: 'Bernstein, A., Forster, S., & Henzinger, M. H. (2019). A deamortization
approach for dynamic spanner and dynamic maximal matching. In 30th Annual ACM-SIAM
Symposium on Discrete Algorithms (pp. 1899–1918). San Diego, CA, United States:
Society for Industrial and Applied Mathematics. https://doi.org/10.1137/1.9781611975482.115'
chicago: Bernstein, Aaron, Sebastian Forster, and Monika H Henzinger. “A Deamortization
Approach for Dynamic Spanner and Dynamic Maximal Matching.” In 30th Annual
ACM-SIAM Symposium on Discrete Algorithms, 1899–1918. Society for Industrial
and Applied Mathematics, 2019. https://doi.org/10.1137/1.9781611975482.115.
ieee: A. Bernstein, S. Forster, and M. H. Henzinger, “A deamortization approach
for dynamic spanner and dynamic maximal matching,” in 30th Annual ACM-SIAM
Symposium on Discrete Algorithms, San Diego, CA, United States, 2019, pp.
1899–1918.
ista: 'Bernstein A, Forster S, Henzinger MH. 2019. A deamortization approach for
dynamic spanner and dynamic maximal matching. 30th Annual ACM-SIAM Symposium on
Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 1899–1918.'
mla: Bernstein, Aaron, et al. “A Deamortization Approach for Dynamic Spanner and
Dynamic Maximal Matching.” 30th Annual ACM-SIAM Symposium on Discrete Algorithms,
Society for Industrial and Applied Mathematics, 2019, pp. 1899–918, doi:10.1137/1.9781611975482.115.
short: A. Bernstein, S. Forster, M.H. Henzinger, in:, 30th Annual ACM-SIAM Symposium
on Discrete Algorithms, Society for Industrial and Applied Mathematics, 2019,
pp. 1899–1918.
conference:
end_date: 2019-01-09
location: San Diego, CA, United States
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 2019-01-06
date_created: 2022-08-16T09:50:33Z
date_published: 2019-01-01T00:00:00Z
date_updated: 2023-02-21T16:31:21Z
day: '01'
doi: 10.1137/1.9781611975482.115
extern: '1'
external_id:
arxiv:
- '1810.10932'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1810.10932
month: '01'
oa: 1
oa_version: Preprint
page: 1899-1918
publication: 30th Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
eisbn:
- 978-1-61197-548-2
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
related_material:
record:
- id: '11871'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: A deamortization approach for dynamic spanner and dynamic maximal matching
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '11898'
abstract:
- lang: eng
text: "We build upon the recent papers by Weinstein and Yu (FOCS'16), Larsen (FOCS'12),
and Clifford et al. (FOCS'15) to present a general framework that gives amortized
lower bounds on the update and query times of dynamic data structures. Using our
framework, we present two concrete results.\r\n(1) For the dynamic polynomial
evaluation problem, where the polynomial is defined over a finite field of size
n1+Ω(1) and has degree n, any dynamic data structure must either have an amortized
update time of Ω((lgn/lglgn)2) or an amortized query time of Ω((lgn/lglgn)2).\r\n(2)
For the dynamic online matrix vector multiplication problem, where we get an n×n
matrix whose entires are drawn from a finite field of size nΘ(1), any dynamic
data structure must either have an amortized update time of Ω((lgn/lglgn)2) or
an amortized query time of Ω(n⋅(lgn/lglgn)2).\r\nFor these two problems, the previous
works by Larsen (FOCS'12) and Clifford et al. (FOCS'15) gave the same lower bounds,
but only for worst case update and query times. Our bounds match the highest unconditional
lower bounds known till date for any dynamic problem in the cell-probe model."
article_processing_charge: No
article_type: original
author:
- first_name: Sayan
full_name: Bhattacharya, Sayan
last_name: Bhattacharya
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Stefan
full_name: Neumann, Stefan
last_name: Neumann
citation:
ama: Bhattacharya S, Henzinger MH, Neumann S. New amortized cell-probe lower bounds
for dynamic problems. Theoretical Computer Science. 2019;779:72-87. doi:10.1016/j.tcs.2019.01.043
apa: Bhattacharya, S., Henzinger, M. H., & Neumann, S. (2019). New amortized
cell-probe lower bounds for dynamic problems. Theoretical Computer Science.
Elsevier. https://doi.org/10.1016/j.tcs.2019.01.043
chicago: Bhattacharya, Sayan, Monika H Henzinger, and Stefan Neumann. “New Amortized
Cell-Probe Lower Bounds for Dynamic Problems.” Theoretical Computer Science.
Elsevier, 2019. https://doi.org/10.1016/j.tcs.2019.01.043.
ieee: S. Bhattacharya, M. H. Henzinger, and S. Neumann, “New amortized cell-probe
lower bounds for dynamic problems,” Theoretical Computer Science, vol.
779. Elsevier, pp. 72–87, 2019.
ista: Bhattacharya S, Henzinger MH, Neumann S. 2019. New amortized cell-probe lower
bounds for dynamic problems. Theoretical Computer Science. 779, 72–87.
mla: Bhattacharya, Sayan, et al. “New Amortized Cell-Probe Lower Bounds for Dynamic
Problems.” Theoretical Computer Science, vol. 779, Elsevier, 2019, pp.
72–87, doi:10.1016/j.tcs.2019.01.043.
short: S. Bhattacharya, M.H. Henzinger, S. Neumann, Theoretical Computer Science
779 (2019) 72–87.
date_created: 2022-08-17T09:02:15Z
date_published: 2019-08-02T00:00:00Z
date_updated: 2022-09-09T11:29:04Z
day: '02'
doi: 10.1016/j.tcs.2019.01.043
extern: '1'
external_id:
arxiv:
- '1902.02304'
intvolume: ' 779'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1902.02304
month: '08'
oa: 1
oa_version: Preprint
page: 72-87
publication: Theoretical Computer Science
publication_identifier:
issn:
- 0304-3975
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: New amortized cell-probe lower bounds for dynamic problems
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 779
year: '2019'
...
---
_id: '11957'
abstract:
- lang: eng
text: Cross-coupling reactions mediated by dual nickel/photocatalysis are synthetically
attractive but rely mainly on expensive, non-recyclable noble-metal complexes
as photocatalysts. Heterogeneous semiconductors, which are commonly used for artificial
photosynthesis and wastewater treatment, are a sustainable alternative. Graphitic
carbon nitrides, a class of metal-free polymers that can be easily prepared from
bulk chemicals, are heterogeneous semiconductors with high potential for photocatalytic
organic transformations. Here, we demonstrate that graphitic carbon nitrides in
combination with nickel catalysis can induce selective C−O cross-couplings of
carboxylic acids with aryl halides, yielding the respective aryl esters in excellent
yield and selectivity. The heterogeneous organic photocatalyst exhibits a broad
substrate scope, is able to harvest green light, and can be recycled multiple
times. In situ FTIR was used to track the reaction progress to study this transformation
at different irradiation wavelengths and reaction scales.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: Jamal A.
full_name: Malik, Jamal A.
last_name: Malik
- first_name: Cristian
full_name: Cavedon, Cristian
last_name: Cavedon
- first_name: Sebastian
full_name: Gisbertz, Sebastian
last_name: Gisbertz
- first_name: Aleksandr
full_name: Savateev, Aleksandr
last_name: Savateev
- first_name: Daniel
full_name: Cruz, Daniel
last_name: Cruz
- first_name: Tobias
full_name: Heil, Tobias
last_name: Heil
- first_name: Guigang
full_name: Zhang, Guigang
last_name: Zhang
- first_name: Peter H.
full_name: Seeberger, Peter H.
last_name: Seeberger
citation:
ama: 'Pieber B, Malik JA, Cavedon C, et al. Semi‐heterogeneous dual nickel/photocatalysis
using carbon nitrides: Esterification of carboxylic acids with aryl halides. Angewandte
Chemie International Edition. 2019;58(28):9575-9580. doi:10.1002/anie.201902785'
apa: 'Pieber, B., Malik, J. A., Cavedon, C., Gisbertz, S., Savateev, A., Cruz, D.,
… Seeberger, P. H. (2019). Semi‐heterogeneous dual nickel/photocatalysis using
carbon nitrides: Esterification of carboxylic acids with aryl halides. Angewandte
Chemie International Edition. Wiley. https://doi.org/10.1002/anie.201902785'
chicago: 'Pieber, Bartholomäus, Jamal A. Malik, Cristian Cavedon, Sebastian Gisbertz,
Aleksandr Savateev, Daniel Cruz, Tobias Heil, Guigang Zhang, and Peter H. Seeberger.
“Semi‐heterogeneous Dual Nickel/Photocatalysis Using Carbon Nitrides: Esterification
of Carboxylic Acids with Aryl Halides.” Angewandte Chemie International Edition.
Wiley, 2019. https://doi.org/10.1002/anie.201902785.'
ieee: 'B. Pieber et al., “Semi‐heterogeneous dual nickel/photocatalysis using
carbon nitrides: Esterification of carboxylic acids with aryl halides,” Angewandte
Chemie International Edition, vol. 58, no. 28. Wiley, pp. 9575–9580, 2019.'
ista: 'Pieber B, Malik JA, Cavedon C, Gisbertz S, Savateev A, Cruz D, Heil T, Zhang
G, Seeberger PH. 2019. Semi‐heterogeneous dual nickel/photocatalysis using carbon
nitrides: Esterification of carboxylic acids with aryl halides. Angewandte Chemie
International Edition. 58(28), 9575–9580.'
mla: 'Pieber, Bartholomäus, et al. “Semi‐heterogeneous Dual Nickel/Photocatalysis
Using Carbon Nitrides: Esterification of Carboxylic Acids with Aryl Halides.”
Angewandte Chemie International Edition, vol. 58, no. 28, Wiley, 2019,
pp. 9575–80, doi:10.1002/anie.201902785.'
short: B. Pieber, J.A. Malik, C. Cavedon, S. Gisbertz, A. Savateev, D. Cruz, T.
Heil, G. Zhang, P.H. Seeberger, Angewandte Chemie International Edition 58 (2019)
9575–9580.
date_created: 2022-08-24T10:50:19Z
date_published: 2019-07-08T00:00:00Z
date_updated: 2023-02-21T10:09:16Z
day: '08'
doi: 10.1002/anie.201902785
extern: '1'
external_id:
pmid:
- '31050132'
intvolume: ' 58'
issue: '28'
language:
- iso: eng
month: '07'
oa_version: None
page: 9575-9580
pmid: 1
publication: Angewandte Chemie International Edition
publication_identifier:
eissn:
- 1521-3773
issn:
- 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Semi‐heterogeneous dual nickel/photocatalysis using carbon nitrides: Esterification
of carboxylic acids with aryl halides'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2019'
...